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[ [ "N-OPTIONALLY SUBSTITUTED ARYL-2-OLIGOMER-3-ALKOXYPROPIONAMIDES", "The invention relates to (among other things) N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides and compositions comprising the same.", "A compound of the invention, when administered by any of a number of administration routes, exhibits one or more advantages over corresponding compounds lacking the oligomer." ], [ "1.A compound selected from the group consisting of (2R) N-benzyl-2-carboxy mPEG1 amino-3-methoxy propionamide, (2R) N-benzyl-2-carboxy mPEG2 amino-3-methoxy propionamide, (2R) N-benzyl-2-carboxy mPEG3 amino-3-methoxy propionamide, (2R) N-benzyl-2-carboxy mPEG4 amino-3-methoxy propionamide, (2R) N-benzyl-2-carboxy mPEG5 amino-3-methoxy propionamide, (2R) N-benzyl-2-carboxy mPEG6 amino-3-methoxy propionamide, (2R) N-benzyl-2-carboxy mPEG7 amino-3-methoxy propionamide, (2R) N-benzyl-2-carboxy mPEG8 amino-3-methoxy propionamide, (2R) N-benzyl-2-carboxy mPEG9 amino-3-methoxy propionamide, and pharmaceutically acceptable salts of each of the foregoing.", "2.A compound comprising a 3-alkoxypropionamide residue covalently attached via a linkage to a water-soluble, non-peptidic oligomer, and pharmaceutically acceptable salts thereof.", "3.The compound of claim 2, encompassed within the formula: wherein: Ar is aryl, optionally substituted with halo; R1 is lower alkyl; the dotted line (“---”) represents a covalent bond, optionally oriented to provide the R enantiomer; X1 is a spacer moiety; and POLY1 is a water-soluble, non-peptidic oligomer, and pharmaceutically acceptable salts thereof.", "4.The compound of claim 2, encompassed within the formula: wherein: Ar is aryl, optionally substituted with halo; R1 is lower alkyl; X1 is a spacer moiety; and POLY1 is a water-soluble, non-peptidic oligomer, and pharmaceutically acceptable salts thereof.", "5.The compound of claim 2, encompassed within the formula: wherein: Ar is aryl, optionally substituted with halo; R1 is lower alkyl; X1 is a spacer moiety; and POLY1 is a water-soluble, non-peptidic oligomer, and pharmaceutically acceptable salts thereof.", "6.The compound of claim 2, wherein the 3-alkoxypropionamide residue is a residue of a 3-alkoxypropionamide encompassed within the formula: wherein: Ar is aryl, optionally substituted with halo; and R1 is lower alkyl, and pharmaceutically acceptable salts thereof.", "7.The compound of claim 2, wherein the 3-alkoxypropionamide residue is a residue of a 3-alkoxypropionamide selected from the group consisting of (R)—N-benzyl-2-acetamido-3-methoxy propionamide, (R)—N-benzyl-2-acetamido-3-ethoxy propionamide, (R)—N-(3-fluorobenzyl)-2-acetamido-3-methoxy propionamide, and (R)—N-(4-fluorobenzyl)-2-acetamido-3-methoxy propionamide.", "8.The compound of claim 7, wherein the 3-alkoxypropionamide residue is a residue of (R)—N-benzyl-2-acetamido-3-methoxy propionamide.", "9.The compound of any one of claims 2-8, wherein the water-soluble, non-peptidic oligomer is a poly(alkylene oxide).", "10.The compound of claim 9, wherein the poly(alkylene oxide) is a poly(ethylene oxide).", "11.The compound of any one claims 2-10, wherein the water-soluble, non-peptidic oligomer has from about 1 to about 30 monomers.", "12.The compound of claim 11, wherein the water-soluble, non-peptidic oligomer has from about 1 to about 10 monomers.", "13.The compound of claim 9, wherein the poly(alkylene oxide) includes an alkoxy or hydroxy end-capping moiety.", "14.The compound of any one of claims 2-13, wherein a single water-soluble, non-peptidic oligomer is covalently attached to the pyrrolidine residue.", "15.The compound of any one of claims 2-13, wherein two water-soluble, non-peptidic oligomers are covalently attached to the pyrrolidine residue.", "16.The compound of any one of claims 2-15, wherein the linkage is a stable linkage.", "17.The compound of any one of claims 2-15, wherein the linkage is a degradable linkage.", "18.A composition comprising a compound encompassed within claim 1 or 2, and optionally, a pharmaceutically acceptable excipient.", "19.A composition of matter comprising a compound encompassed within claim 1 or 2, wherein the compound is present in a dosage form.", "20.A method of making a conjugate, the method comprising covalently attaching a water-soluble, non-peptidic oligomer to a 3-alkoxypropionamide moiety.", "21.A method comprising administering to a mammal a compound encompassed within claim 1 or 2." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures.", "These seizures are transient signs and/or symptoms of abnormal, excessive or synchronous neuronal activity in the brain.", "About 50 million people worldwide have epilepsy, with almost 90% of these people residing in developing countries.", "Epilepsy is more likely to occur in young children or people over the age of 65 years; however, it can occur at any age.", "Epilepsy is usually controlled, but not cured, with pharmacotherapy, although surgery may be indicated in exceptional cases.", "Despite the reliance on pharmacotherapy as the primary approach in controlling the disease, over 30% of people with epilepsy do not have seizure control even with the best available medications.", "Not all epilepsy syndromes are life-long; some forms are confined to particular stages of childhood.", "Epilepsy should not be understood as a single disorder, but rather as a group of syndromes with vastly divergent symptoms, but all involving episodic abnormal electrical activity in the brain.", "Seizure types are organized firstly according to whether the source of the seizure within the brain is localized (partial or focal onset seizures) or distributed (generalized seizures).", "Partial seizures are further divided on the extent to which consciousness is affected.", "If it is unaffected, then it is a simple partial seizure; otherwise it is a complex partial (psychomotor) seizure.", "A partial seizure may spread within the brain—a process known as secondary generalization.", "Generalized seizures are divided according to the effect on the body, but all involve loss of consciousness.", "These include absence (petit mal), myoclonic, clonic, tonic, tonic-clonic (grand mal) and atonic seizures.", "There are over 40 different types of epileptic conditions, including: absence seizures, atonic seizures, benign Rolandic epilepsy, childhood absence, clonic seizures, complex partial seizures, frontal lobe epilepsy, febrile seizures, infantile spasms, juvenile myoclonic epilepsy, juvenile absence epilepsy, Lennox-Gastaut syndrome, Landau-Kleffner syndrome, myoclonic seizures, mitochondrial disorders, progressive myoclonic epilepsies, psychogenic seizures, reflex epilepsy, Rasmussen's syndrome, simple partial seizures, secondarily generalized seizures, temporal lobe epilepsy, toni-clonic seizures, tonic seizures, psychomotor seizures, limbic epilepsy, partial-onset seizures, generalized-onset seizures, status epilepticus, abdominal epilepsy, akinetic seizures, auto-nomic seizures, massive bilateral myoclonus, catamenial epilepsy, drop seizures, emotional seizures, focal seizures, gelastic seizures, Jacksonian march, Lafora disease, motor seizures, multifocal seizures, neonatal seizures, nocturnal seizures, photosensitive seizure, pseudo seizures, sensory seizures, subtle seizures, Sylvan seizures, withdrawal seizures, and visual reflex seizures, among others.", "Anticonvulsants are generally prescribed for the treatment of individuals suffering from or prone to epilepsy.", "The 3-alkoxypropionamides represent one such class of compounds.", "The 3-alkoxypropionamides are also used in the treatment of individuals suffering from or prone to neuropathic pain.", "Treatment of individuals with these compounds, however, is associated with many side effects, including: vertigo; diplopia; blurred vision; nausea; vomiting; dizziness; ataxia; and tremor.", "Therefore, pharmacotherapy with such therapeutic 3-alkoxypropionamides would be improved if these and/or other adverse or side effects associated with their use could be decreased or if their pharmacology could otherwise be improved for this and/or for other indications.", "Thus, there is a large unmet need for developing novel 3-alkoxypropionamides.", "The present invention seeks to address these and other needs in the art." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>In one or more embodiments of the invention, N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides are provided.", "In one or more embodiments of the invention a compound is provided, the compound comprising a 3-alkoxypropionamide residue covalently attached via a stable or degradable linkage to a water-soluble, non-peptidic oligomer.", "The “3-alkoxypropionamide residue” is a compound having a structure of a therapeutically active 3-alkoxypropionamide that is altered by the presence of one or more bonds, which bonds serve to attach (either directly or indirectly) one or more water-soluble, non-peptidic oligomers.", "Exemplary compounds of the invention include those having the following structure: wherein: Ar is aryl, optionally substituted (e.g., optionally substituted with halo); R 1 is lower alkyl; the dotted line (“---”) represents a covalent bond, optionally oriented to provide the R enantiomer; X 1 is a spacer moiety; POLY 1 is a water-soluble, non-peptidic oligomer.", "In this regard, any 3-alkoxypropionamide having anti-epileptic and/or analgesic activity can be used as the 3-alkoxypropionamide from which the 3-alkoxypropionamide residue is obtained.", "Exemplary 3-alkoxypropionamides have a structure encompassed by Formula I: wherein: Ar is aryl, optionally substituted with halo; and R 1 is lower alkyl.", "An exemplary 3-alkoxypropionamide for use in the current invention is lacosamide.", "In one or more embodiments of the invention, N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides are provided.", "In one or more embodiments of the invention, a composition is provided, the composition comprising an N-optionally substituted aryl-2-oligomer-3-alkoxypropionamide, and optionally, a pharmaceutically acceptable excipient.", "In one or more embodiments of the invention, a compound is provided, the compound comprising a 3-alkoxypropionamide residue covalently attached via a stable or degradable linkage to a water-soluble, non-peptidic oligomer.", "In one or more embodiments of the invention, a composition is provided, the composition comprising a compound comprising a 3-alkoxypropionamide residue covalently attached via a stable or degradable linkage to a water-soluble, non-peptidic oligomer, and optionally, a pharmaceutically acceptable excipient.", "In one or more embodiments of the invention, a dosage form is provided, the dosage form comprising a compound as described herein, wherein the compound is present in a dosage form.", "In one or more embodiments of the invention, a method is provided, the method comprising covalently attaching a water-soluble, non-peptidic oligomer to a 3-alkoxypropionamide.", "In one or more embodiments of the invention, a method is provided, the method comprising administering a compound as described herein to a mammal in need thereof.", "Additional embodiments of the present conjugates, compositions, methods, and the like will be apparent from the following description, examples, and claims.", "As can be appreciated from the foregoing and following description, each and every feature described herein, and each and every combination of two or more of such features, is included within the scope of the present disclosure provided that the features included in such a combination are not mutually inconsistent.", "In addition, any feature or combination of features may be specifically excluded from any embodiment of the present invention.", "Additional aspects and advantages of the present invention are set forth in the following description and claims." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation application of U.S. patent application Ser.", "No.", "15/445,381, filed Feb. 28, 2017, which is a continuation application of U.S. patent application Ser.", "No.", "14/951,105, filed Nov. 24, 2015, now U.S. Pat.", "No.", "9,616,136, which is a continuation application of U.S. patent application Ser.", "No.", "13/879,603, filed Apr.", "8, 2014, now U.S. Pat.", "No.", "9,226,971, which is a 35 U.S.C.", "§ 371 application of International Application No.", "PCT/US2011/056391, filed Oct. 14, 2011, designating the United States, which claims the benefit of priority under 35 U.S.C.", "§ 119(e) to U.S.", "Provisional Patent Application No.", "61/393,699, filed Oct. 15, 2010, the disclosures of which are incorporated herein by reference in their entireties.", "FIELD OF THE INVENTION This invention comprises (among other things) N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides.", "The N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides described herein relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology, organic chemistry and polymer chemistry.", "BACKGROUND OF THE INVENTION Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures.", "These seizures are transient signs and/or symptoms of abnormal, excessive or synchronous neuronal activity in the brain.", "About 50 million people worldwide have epilepsy, with almost 90% of these people residing in developing countries.", "Epilepsy is more likely to occur in young children or people over the age of 65 years; however, it can occur at any age.", "Epilepsy is usually controlled, but not cured, with pharmacotherapy, although surgery may be indicated in exceptional cases.", "Despite the reliance on pharmacotherapy as the primary approach in controlling the disease, over 30% of people with epilepsy do not have seizure control even with the best available medications.", "Not all epilepsy syndromes are life-long; some forms are confined to particular stages of childhood.", "Epilepsy should not be understood as a single disorder, but rather as a group of syndromes with vastly divergent symptoms, but all involving episodic abnormal electrical activity in the brain.", "Seizure types are organized firstly according to whether the source of the seizure within the brain is localized (partial or focal onset seizures) or distributed (generalized seizures).", "Partial seizures are further divided on the extent to which consciousness is affected.", "If it is unaffected, then it is a simple partial seizure; otherwise it is a complex partial (psychomotor) seizure.", "A partial seizure may spread within the brain—a process known as secondary generalization.", "Generalized seizures are divided according to the effect on the body, but all involve loss of consciousness.", "These include absence (petit mal), myoclonic, clonic, tonic, tonic-clonic (grand mal) and atonic seizures.", "There are over 40 different types of epileptic conditions, including: absence seizures, atonic seizures, benign Rolandic epilepsy, childhood absence, clonic seizures, complex partial seizures, frontal lobe epilepsy, febrile seizures, infantile spasms, juvenile myoclonic epilepsy, juvenile absence epilepsy, Lennox-Gastaut syndrome, Landau-Kleffner syndrome, myoclonic seizures, mitochondrial disorders, progressive myoclonic epilepsies, psychogenic seizures, reflex epilepsy, Rasmussen's syndrome, simple partial seizures, secondarily generalized seizures, temporal lobe epilepsy, toni-clonic seizures, tonic seizures, psychomotor seizures, limbic epilepsy, partial-onset seizures, generalized-onset seizures, status epilepticus, abdominal epilepsy, akinetic seizures, auto-nomic seizures, massive bilateral myoclonus, catamenial epilepsy, drop seizures, emotional seizures, focal seizures, gelastic seizures, Jacksonian march, Lafora disease, motor seizures, multifocal seizures, neonatal seizures, nocturnal seizures, photosensitive seizure, pseudo seizures, sensory seizures, subtle seizures, Sylvan seizures, withdrawal seizures, and visual reflex seizures, among others.", "Anticonvulsants are generally prescribed for the treatment of individuals suffering from or prone to epilepsy.", "The 3-alkoxypropionamides represent one such class of compounds.", "The 3-alkoxypropionamides are also used in the treatment of individuals suffering from or prone to neuropathic pain.", "Treatment of individuals with these compounds, however, is associated with many side effects, including: vertigo; diplopia; blurred vision; nausea; vomiting; dizziness; ataxia; and tremor.", "Therefore, pharmacotherapy with such therapeutic 3-alkoxypropionamides would be improved if these and/or other adverse or side effects associated with their use could be decreased or if their pharmacology could otherwise be improved for this and/or for other indications.", "Thus, there is a large unmet need for developing novel 3-alkoxypropionamides.", "The present invention seeks to address these and other needs in the art.", "SUMMARY OF THE INVENTION In one or more embodiments of the invention, N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides are provided.", "In one or more embodiments of the invention a compound is provided, the compound comprising a 3-alkoxypropionamide residue covalently attached via a stable or degradable linkage to a water-soluble, non-peptidic oligomer.", "The “3-alkoxypropionamide residue” is a compound having a structure of a therapeutically active 3-alkoxypropionamide that is altered by the presence of one or more bonds, which bonds serve to attach (either directly or indirectly) one or more water-soluble, non-peptidic oligomers.", "Exemplary compounds of the invention include those having the following structure: wherein: Ar is aryl, optionally substituted (e.g., optionally substituted with halo); R1 is lower alkyl; the dotted line (“---”) represents a covalent bond, optionally oriented to provide the R enantiomer; X1 is a spacer moiety; POLY1 is a water-soluble, non-peptidic oligomer.", "In this regard, any 3-alkoxypropionamide having anti-epileptic and/or analgesic activity can be used as the 3-alkoxypropionamide from which the 3-alkoxypropionamide residue is obtained.", "Exemplary 3-alkoxypropionamides have a structure encompassed by Formula I: wherein: Ar is aryl, optionally substituted with halo; and R1 is lower alkyl.", "An exemplary 3-alkoxypropionamide for use in the current invention is lacosamide.", "In one or more embodiments of the invention, N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides are provided.", "In one or more embodiments of the invention, a composition is provided, the composition comprising an N-optionally substituted aryl-2-oligomer-3-alkoxypropionamide, and optionally, a pharmaceutically acceptable excipient.", "In one or more embodiments of the invention, a compound is provided, the compound comprising a 3-alkoxypropionamide residue covalently attached via a stable or degradable linkage to a water-soluble, non-peptidic oligomer.", "In one or more embodiments of the invention, a composition is provided, the composition comprising a compound comprising a 3-alkoxypropionamide residue covalently attached via a stable or degradable linkage to a water-soluble, non-peptidic oligomer, and optionally, a pharmaceutically acceptable excipient.", "In one or more embodiments of the invention, a dosage form is provided, the dosage form comprising a compound as described herein, wherein the compound is present in a dosage form.", "In one or more embodiments of the invention, a method is provided, the method comprising covalently attaching a water-soluble, non-peptidic oligomer to a 3-alkoxypropionamide.", "In one or more embodiments of the invention, a method is provided, the method comprising administering a compound as described herein to a mammal in need thereof.", "Additional embodiments of the present conjugates, compositions, methods, and the like will be apparent from the following description, examples, and claims.", "As can be appreciated from the foregoing and following description, each and every feature described herein, and each and every combination of two or more of such features, is included within the scope of the present disclosure provided that the features included in such a combination are not mutually inconsistent.", "In addition, any feature or combination of features may be specifically excluded from any embodiment of the present invention.", "Additional aspects and advantages of the present invention are set forth in the following description and claims.", "BRIEF DESCRIPTION OF THE DRAWING FIG.", "1 is the voltage protocol for the hNav1.8 test procedure described in further detail in Example 2.FIG.", "2 is a graph of the Phase 1 and Phase 2 measurements of flinches induced by formalin administration as further described in Example 4.DETAILED DESCRIPTION OF THE INVENTION As used in this specification, the singular forms “a,” “an,” and “the” include plural referents unless the context clearly dictates otherwise.", "In describing and claiming the present invention, the following terminology will be used in accordance with the definitions described below.", "“Water soluble, non-peptidic oligomer” indicates an oligomer that is at least 35% (by weight) soluble, preferably greater than 70% (by weight), and more preferably greater than 95% (by weight) soluble, in water at room temperature.", "Typically, an unfiltered aqueous preparation of a “water-soluble” oligomer transmits at least 75%, more preferably at least 95%, of the amount of light transmitted by the same solution after filtering.", "It is most preferred, however, that the water-soluble oligomer is at least 95% (by weight) soluble in water or completely soluble in water.", "With respect to being “non-peptidic,” an oligomer is non-peptidic when it has less than 35% (by weight) of amino acid residues.", "The terms “monomer,” “monomeric subunit” and “monomeric unit” are used interchangeably herein and refer to one of the basic structural units of a polymer or oligomer.", "In the case of a homo-oligomer, a single repeating structural unit forms the oligomer.", "In the case of a co-oligomer, two or more structural units are repeated—either in a pattern or randomly—to form the oligomer.", "Preferred oligomers used in connection with present the invention are homo-oligomers.", "The water-soluble, non-peptidic oligomer comprises one or more monomers serially attached to form a chain of monomers.", "The oligomer can be formed from a single monomer type (i.e., is homo-oligomeric) or two or three monomer types (i.e., is co-oligomeric).", "An “oligomer” is a molecule possessing from about 1 to about 30 monomers.", "Specific oligomers for use in the invention include those having a variety of geometries such as linear, branched, or forked, to be described in greater detail below.", "“PEG” or “polyethylene glycol,” as used herein, is meant to encompass any water-soluble poly(ethylene oxide).", "Unless otherwise indicated, a “PEG oligomer” or an oligoethylene glycol is one in which substantially all (preferably all) monomeric subunits are ethylene oxide subunits, though, the oligomer may contain distinct end capping moieties or functional groups, e.g., for conjugation.", "PEG oligomers for use in the present invention will comprise one of the two following structures: “—(CH2CH2O)n—” or “—(CH2CH2O)n-1CH2CH2—,” depending upon whether or not the terminal oxygen(s) has been displaced, e.g., during a synthetic transformation.", "As stated above, for the PEG oligomers, the variable (n) ranges from about 1 to 30, and the terminal groups and architecture of the overall PEG can vary.", "When PEG further comprises a functional group, A, for linking to, e.g., a small molecule drug, the functional group when covalently attached to a PEG oligomer does not result in formation of (i) an oxygen-oxygen bond (—O—, a peroxide linkage), or (ii) a nitrogen-oxygen bond (N—O, O—N).", "The terms “end-capped” or “terminally capped” are interchangeably used herein to refer to a terminal or endpoint of a polymer having an end-capping moiety.", "Typically, although not necessarily, the end-capping moiety comprises a hydroxy or C1-20 alkoxy group.", "Thus, examples of end-capping moieties include alkoxy (e.g., methoxy, ethoxy and benzyloxy), as well as aryl, heteroaryl, cyclo, heterocyclo, and the like.", "In addition, saturated, unsaturated, substituted and unsubstituted forms of each of the foregoing are envisioned.", "Moreover, the end-capping group can also be a silane.", "The end-capping group can also advantageously comprise a detectable label.", "When the oligomer has an end-capping group comprising a detectable label, the amount or location of the oligomer and/or the moiety (e.g., active agent) of interest to which the oligomer is coupled, can be determined by using a suitable detector.", "Such labels include, without limitation, fluorescers, chemiluminescers, moieties used in enzyme labeling, colorimetric moieties (e.g., dyes), metal ions, radioactive moieties, and the like.", "Suitable detectors include photometers, films, spectrometers, and the like.", "In addition, the end-capping group may contain a targeting moiety.", "The term “targeting moiety” is used herein to refer to a molecular structure that helps the compounds of the invention to localize to a targeting area, e.g., help enter a cell, or bind a receptor.", "Preferably, the targeting moiety comprises a vitamin, antibody, antigen, receptor, DNA, RNA, sialyl Lewis X antigen, hyaluronic acid, sugars, cell-specific lectins, steroid or steroid derivative, RGD peptide, ligand for a cell surface receptor, serum component, or combinatorial molecule directed against various intra- or extracellular receptors.", "The targeting moiety may also comprise a lipid or a phospholipid.", "Exemplary phospholipids include, without limitation, phosphatidylcholines, phosphatidylserine, phosphatidylinositol, phosphatidylglycerol, and phosphatidylethanolamine.", "These lipids may be in the form of micelles or liposomes and the like.", "The targeting moiety may further comprise a detectable label or alternately a detectable label may serve as a targeting moiety.", "“Branched,” in reference to the geometry or overall structure of an oligomer, refers to an oligomer having two or more polymer “arms” extending from a branch point.", "“Forked,” in reference to the geometry or overall structure of an oligomer, refers to an oligomer having two or more functional groups (typically through one or more atoms) extending from a branch point.", "A “branch point” refers to a bifurcation point comprising one or more atoms at which an oligomer branches or forks from a linear structure into one or more additional arms.", "The terms “reactive” and “activated” refer to a functional group that reacts readily or at a practical rate under conventional conditions of organic synthesis.", "This is in contrast to those groups that either do not react or require strong catalysts or impractical reaction conditions in order to react (i.e., a “nonreactive” or “inert” group).", "“Not readily reactive,” with reference to a functional group present on a molecule in a reaction mixture, indicates that the group remains largely intact under conditions that are effective to produce a desired reaction in the reaction mixture.", "A “protecting group” is a moiety that prevents or blocks reaction of a particular chemically reactive functional group in a molecule under certain reaction conditions.", "The protecting group may vary depending upon the type of chemically reactive group being protected as well as the reaction conditions to be employed and the presence of additional reactive or protecting groups in the molecule.", "Functional groups which may be protected include, by way of example, carboxylic acid groups, amino groups, hydroxyl groups, thiol groups, carbonyl groups and the like.", "Representative protecting groups for carboxylic acids include esters (such as a p-methoxybenzyl ester), amides and hydrazides; for amino groups, carbamates (such as tert-butoxycarbonyl) and amides; for hydroxyl groups, ethers and esters; for thiol groups, thioethers and thioesters; for carbonyl groups, acetals and ketals; and the like.", "Such protecting groups are well-known to those skilled in the art and are described, for example, in T. W. Greene and G. M. Wuts, Protecting Groups in Organic Synthesis, Third Edition, Wiley, New York, 1999, and references cited therein.", "A functional group in “protected form” refers to a functional group bearing a protecting group.", "As used herein, the term “functional group” or any synonym thereof encompasses protected forms thereof.", "A “physiologically cleavable” or “hydrolyzable” or “degradable” bond is releasable linkage that reacts with water (i.e., is hydrolyzed) under physiological conditions.", "The tendency of a bond to hydrolyze in water may depend not only on the general type of linkage connecting two central atoms but also on the substituents attached to these central atoms.", "Appropriate hydrolytically unstable or weak linkages include but are not limited to carboxylate ester, phosphate ester, anhydrides, acetals, ketals, acyloxyalkyl ether, imines, orthoesters, peptides, oligonucleotides, thioesters, and carbonates.", "An “enzymatically degradable linkage” means a linkage that is subject to degradation by one or more enzymes.", "A “stable” linkage or bond refers to a chemical bond that is substantially stable in water, that is to say, does not undergo hydrolysis under physiological conditions to any appreciable extent over an extended period of time.", "Examples of hydrolytically stable linkages include but are not limited to the following: carbon-carbon bonds (e.g., in aliphatic chains), ethers, amides, urethanes, amines, and the like.", "Generally, a stable linkage is one that exhibits a rate of hydrolysis of less than about 1-2% per day under physiological conditions.", "Hydrolysis rates of representative chemical bonds can be found in most standard chemistry textbooks.", "“Substantially” or “essentially” means nearly totally or completely, for instance, 95% or greater, more preferably 97% or greater, still more preferably 98% or greater, even more preferably 99% or greater, yet still more preferably 99.9% or greater, with 99.99% or greater being most preferred of some given quantity.", "“Monodisperse” refers to an oligomer composition wherein substantially all of the oligomers in the composition have a well-defined, single molecular weight and defined number of monomers, as determined by chromatography or mass spectrometry.", "Monodisperse oligomer compositions are in one sense pure, that is, substantially having a single and definable number (as a whole number) of monomers rather than a large distribution.", "A monodisperse oligomer composition possesses a MW/Mn value of 1.0005 or less, and more preferably, a MW/Mn value of 1.0000.By extension, a composition comprised of monodisperse conjugates means that substantially all oligomers within all compounds in the composition have a single and definable number (as a whole number) of monomers rather than a large distribution and would possess a MW/Mn value of 1.0005, and more preferably, a MW/Mn value of 1.0000 if the oligomer were not attached to the therapeutic moiety.", "A composition comprised of monodisperse conjugates may, for example, include one or more nonconjugate substances such as solvents, reagents, excipients, and so forth.", "“Bimodal,” in reference to an oligomer composition, refers to an oligomer composition wherein substantially all oligomers in the composition have one of two definable and different numbers (as whole numbers) of monomers rather than a large distribution, and whose distribution of molecular weights, when plotted as a number fraction versus molecular weight, appears as two separate identifiable peaks.", "Preferably, for a bimodal oligomer composition as described herein, each peak is generally symmetric about its mean, although the size of the two peaks may differ.", "Ideally, the polydispersity index of each peak in the bimodal distribution, Mw/Mn, is 1.01 or less, more preferably 1.001 or less, and even more preferably 1.0005 or less, and most preferably a MW/Mn value of 1.0000.By extension, a composition comprised of bimodal conjugates means that substantially all oligomers of all conjugates in the composition have one of two definable and different numbers (as whole numbers) of monomers rather than a large distribution and would possess a MW/Mn value of 1.01 or less, more preferably 1.001 or less and even more preferably 1.0005 or less, and most preferably a MW/Mn value of 1.0000 if the oligomer were not attached to the therapeutic moiety.", "A composition comprised of bimodal conjugates may, for example, include one or more nonconjugate substances such as solvents, reagents, excipients, and so forth.", "A “3-alkoxypropionamide” is broadly used herein to refer to an organic, inorganic, or organometallic compound having a molecular weight of less than about 1000 Daltons (more preferably less than about 500 Daltons and most preferably having less than about 300 Daltons) and having some degree of activity as an anti-epileptic and/or analgesic.", "Assays known to those of ordinary skill in the art can be used to determine whether a given 3-alkoxypropionamide (as well as a compound provided herein) has activity as an anti-epileptic and/or analgesic.", "A “biological membrane” is any membrane made of cells or tissues that serves as a barrier to at least some foreign entities or otherwise undesirable materials.", "As used herein a “biological membrane” includes those membranes that are associated with physiological protective barriers including, for example: the blood-brain barrier (BBB); the blood-cerebrospinal fluid barrier; the blood-placental barrier; the blood-milk barrier; the blood-testes barrier; and mucosal barriers including the vaginal mucosa, urethral mucosa, anal mucosa, buccal mucosa, sublingual mucosa, and rectal mucosa.", "Unless the context clearly dictates otherwise, the term “biological membrane” does not include those membranes associated with the middle gastro-intestinal tract (e.g., stomach and small intestines).", "A “biological membrane crossing rate,” provides a measure of a compound's ability to cross a biological membrane, such as the blood-brain barrier (“BBB”).", "A variety of methods may be used to assess transport of a molecule across any given biological membrane.", "Methods to assess the biological membrane crossing rate associated with any given biological barrier (e.g., the blood-cerebrospinal fluid barrier, the blood-placental barrier, the blood-milk barrier, the intestinal barrier, and so forth), are known, described herein and/or in the relevant literature, and/or may be determined by one of ordinary skill in the art.", "A “reduced rate of metabolism” refers to a measurable reduction in the rate of metabolism of a water-soluble oligomer-small molecule drug conjugate as compared to the rate of metabolism of the small molecule drug not attached to the water-soluble oligomer (i.e., the small molecule drug itself) or a reference standard material.", "In the special case of “reduced first pass rate of metabolism,” the same “reduced rate of metabolism” is required except that the small molecule drug (or reference standard material) and the corresponding conjugate are administered orally.", "Orally administered drugs are absorbed from the gastro-intestinal tract into the portal circulation and may pass through the liver prior to reaching the systemic circulation.", "Because the liver is the primary site of drug metabolism or biotransformation, a substantial amount of drug may be metabolized before it ever reaches the systemic circulation.", "The degree of first pass metabolism, and thus, any reduction thereof, may be measured by a number of different approaches.", "For instance, animal blood samples may be collected at timed intervals and the plasma or serum analyzed by liquid chromatography/mass spectrometry for metabolite levels.", "Other techniques for measuring a “reduced rate of metabolism” associated with the first pass metabolism and other metabolic processes are known, described herein and/or in the relevant literature, and/or may be determined by one of ordinary skill in the art.", "Preferably, a compound of the invention may provide a reduced rate of metabolism [relative to a compound lacking a water-soluble, non-peptidic oligomers) satisfying at least one of the following values: at least about 30%; at least about 40%; at least about 50%; at least about 60%; at least about 70%; at least about 80%; and at least about 90%.", "A compound (such as a small molecule drug or conjugate thereof) that is “orally bioavailable” is one that preferably possesses a bioavailability when administered orally of greater than 25%, and preferably greater than 70%, where a compound's bioavailability is the fraction of administered drug that reaches the systemic circulation in unmetabolized form.", "“Alkyl” refers to a hydrocarbon chain, ranging from about 1 to 20 atoms in length.", "Such hydrocarbon chains are preferably but not necessarily saturated and may be branched or straight chain.", "Exemplary alkyl groups include methyl, ethyl, propyl, butyl, pentyl, 2-methylbutyl, 2-ethylpropyl, 3-methylpentyl, and the like.", "As used herein, “alkyl” includes cycloalkyl when three or more carbon atoms are referenced.", "An “alkenyl” group is an alkyl of 2 to 20 carbon atoms with at least one carbon-carbon double bond.", "The terms “substituted alkyl” or “substituted Cq-r alkyl” where q and r are integers identifying the range of carbon atoms contained in the alkyl group, denotes the above alkyl groups that are substituted by one, two or three halo (e.g., F, Cl, Br, I), trifluoromethyl, hydroxy, C1-7 alkyl (e.g., methyl, ethyl, n-propyl, isopropyl, butyl, t-butyl, and so forth), C1-7 alkoxy, C1-7 acyloxy, C3-7 heterocyclic, amino, phenoxy, nitro, carboxy, acyl, cyano.", "The substituted alkyl groups may be substituted once, twice or three times with the same or with different substituents.", "“Lower alkyl” refers to an alkyl group containing from 1 to 6 carbon atoms, and may be straight chain or branched, as exemplified by methyl, ethyl, n-butyl, i-butyl, t-butyl.", "“Lower alkenyl” refers to a lower alkyl group of 2 to 6 carbon atoms having at least one carbon-carbon double bond.", "“Non-interfering substituents” are those groups that, when present in a molecule, are typically non-reactive with other functional groups contained within the molecule.", "“Alkoxy” refers to an —O—R group, wherein R is alkyl or substituted alkyl, preferably C1-C20 alkyl (e.g., methoxy, ethoxy, propyloxy, etc.", "), preferably C1-C7.“Pharmaceutically acceptable excipient” or “pharmaceutically acceptable carrier” refers to a component that may be included in the compositions of the invention causes no significant adverse toxicological effects to a patient.", "The term “aryl” means an aromatic-containing group having up to 14 carbon atoms.", "Aryl groups include benzyl, phenyl, naphthyl, biphenyl, phenanthrenyl, naphthalenyl, and the like.", "“Substituted phenyl,” “substituted benzyl” and “substituted aryl” denote a phenyl group, benzyl group and aryl group, respectively, substituted with one, two, three, four or five (e.g., 1-2, 1-3 or 1-4 substituents) chosen from halo (e.g., F, Cl, Br, I), hydroxy, cyano, nitro, alkyl (e.g., C1-6 alkyl), alkoxy (e.g., C1-6 alkoxy), benzyloxy, carboxy, aryl, and so forth.", "Chemical moieties are defined and referred to throughout primarily as univalent chemical moieties (e.g., alkyl, aryl, etc.).", "Nevertheless, such terms are also used to convey corresponding multivalent moieties under the appropriate structural circumstances clear to those skilled in the art.", "For example, while an “alkyl” moiety generally refers to a monovalent radical (e.g., CH3—CH2—), in certain circumstances a bivalent linking moiety can be “alkyl,” in which case those skilled in the art will understand the alkyl to be a divalent radical (e.g., —CH2—CH2—), which is equivalent to the term “alkylene.” (Similarly, in circumstances in which a divalent moiety is required and is stated as being “aryl,” those skilled in the art will understand that the term “aryl” refers to the corresponding multivalent moiety, arylene).", "All atoms are understood to have their normal number of valences for bond formation (i.e., 1 for H, 4 for carbon, 3 for N, 2 for O, and 2, 4, or 6 for S, depending on the oxidation state of the S).", "“Pharmacologically effective amount,” “physiologically effective amount,” and “therapeutically effective amount” are used interchangeably herein to mean the amount of the compound of the invention present in a composition that is needed to provide a desired level of the compound (or desired metabolite thereof) in the bloodstream or in the target tissue.", "The precise amount may depend upon numerous factors, e.g., the particular active agent, the components and physical characteristics of the composition, intended patient population, patient considerations, and may readily be determined by one skilled in the art, based upon the information provided herein and available in the relevant literature.", "A “difunctional” oligomer is an oligomer having two functional groups contained therein, typically at its termini.", "When the functional groups are the same, the oligomer is said to be homodifunctional.", "When the functional groups are different, the oligomer is said to be heterodifunctional.", "A basic reactant or an acidic reactant described herein include neutral, charged, and any corresponding salt forms thereof.", "The term “patient,” refers to a living organism suffering from or prone to a condition that can be prevented or treated by administration of a compound of the invention as described herein, and includes both humans and animals.", "“Optional” or “optionally” means that the subsequently described circumstance may but need not necessarily occur, so that the description includes instances where the circumstance occurs and instances where it does not.", "As indicated above, the present invention is directed to (among other things) N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides.", "By way of “N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides” are meant propionamides, wherein: the nitrogen of the propionamide is N-substituted with an aryl group (which aryl group is optionally substituted); the “2-position” carbon of the propionamide has attached to it (optionally arranged so as to provide the R-enantiomer), directly or via a spacer moiety, a water-soluble, non-peptidic oligomer; and the “3-position” carbon of the propronamide has attached to it an alkoxy group.", "These features of N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides are schematically provided below: Exemplary N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides of the invention include those having the following structure: wherein: Ar is aryl, optionally substituted with halo; R1 is lower alkyl; the dotted line (“---”) represents a covalent bond, optionally oriented to provide the R enantiomer; X1 is a spacer moiety; and POLY1 is a water-soluble, non-peptidic oligomer.", "Further, exemplary compounds of Formula Ia-C include those having the following structure: wherein: Ar is aryl, optionally substituted with halo; R1 is lower alkyl; X1 is a spacer moiety; and POLY1 is a water-soluble, non-peptidic oligomer.", "Still further exemplary compounds of Formula Ia-C include those having the following structure: wherein: Ar is aryl, optionally substituted with halo; R1 is lower alkyl; X1 is a spacer moiety; and POLY1 is a water-soluble, non-peptidic oligomer.", "Other compounds of interest that may be useful as (among other things) probes to determine binding affinity include those encompassed by the following structure: wherein: Ar is aryl, optionally substituted with halo; the dotted line (“---”) represents a covalent bond, optionally oriented to provide the R enantiomer; X1 is a spacer moiety (preferably —O—); and POLY1 is a water-soluble, non-peptidic oligomer.", "Still exemplary compounds of interest that may be useful as (among other things) probes to determine binding affinity include those encompassed by the following formula: wherein: Ar—X1-POLY1 is aryl substituted with —X1—POLY1 and further optionally substituted with halo, wherein X1 is a spacer moiety (preferably —O—, —S— or —NH—) and POLY1 is a water-soluble, non-peptidic oligomer; the dotted line (“---”) represents a covalent bond, optionally oriented to provide the R enantiomer; and R1 is lower alkyl.", "As indicated above, the present invention is directed to (among other things) a compound comprising a 3-alkoxypropionamide residue covalently attached via a stable or degradable linkage to a water-soluble, non-peptidic oligomer.", "The “3-alkoxypropionamide residue” is a compound having a structure of a 3-alkoxypropionamide that is altered by the presence of one or more bonds, which bonds serve to attach (either directly or indirectly) one or more water-soluble, non-peptidic oligomers.", "Exemplary 3-alkoxypropionamides have a structure encompassed by Formula I: wherein: Ar is aryl, optionally substituted with halo; and R1 is lower alkyl.", "As previously indicated, the nitrogen of the propionamide within the N-optionally substituted aryl-2-oligomer-3-alkoxypropionamide is N-substituted with an aryl group.", "Preferably, the aryl group is a benzyl group, although the invention is not limited in this regard.", "Further, the aryl group (e.g., a benzyl group) is optionally substituted with, for example, one or more lower alkyls and/or halo atoms.", "When the aryl group is substituted, it is preferred that the aryl group is halo-substituted.", "In one or more embodiments of the invention, a compound is provided, the compound comprising a 3-alkoxypropionamide residue covalently attached via a stable or degradable linkage to a water-soluble, non-peptidic oligomer, wherein the 3-alkoxypropionamide residue (in a form in which the water-soluble, non-peptidic oligomer is not present) corresponds to lacosamide [i.e., (R)—N-benzyl-2-acetamido-3-methoxy propionamide].", "The following list provides the chemical structures of these and other exemplary 3-alkoxypropionamide moieties: (R)—N-benzyl-2-acetamido-3-methoxy propionamide (lacosamide); (R)—N-benzyl-2-acetamido-3-ethoxy propionamide; (R)—N-(3-fluorobenzyl)-2-acetamido-3-methoxy propionamide; and (R)—N-(4-fluorobenzyl)-2-acetamido-3-methoxy propionamide.", "In some instances, a 3-alkoxypropionamide that is useful as a starting material or intermediate in synthesizing the compounds of the invention can be obtained from commercial sources.", "In addition, 3-alkoxypropionamides can be obtained through chemical synthesis.", "Further examples of 3-alkoxypropionamides, as well as synthetic approaches for preparing 3-alkoxypropionamides, are described in the literature and in, for example, U.S. Reissue Pat.", "No.", "RE 38,551 and U.S. Pat.", "No.", "5,654,301.Each of these (and other) 3-alkoxypropionamides can be covalently attached (either directly or through one or more atoms) to a water-soluble, non-peptidic oligomer following the techniques and approaches described herein.", "With respect to the water-soluble, non-peptidic oligomer, use of discrete oligomers (e.g., from a monodisperse or bimodal composition of oligomers, in contrast to relatively impure compositions) to form oligomer-containing compounds are preferred.", "For instance, a compound of the invention, when administered by any of a number of suitable administration routes, such as parenteral, oral, transdermal, buccal, pulmonary, or nasal, exhibits reduced penetration across the blood-brain barrier.", "It is preferred that the compounds of the invention exhibit slowed, minimal or effectively no crossing of the blood-brain barrier, while still crossing the gastro-intestinal (GI) walls and into the systemic circulation when oral delivery is intended.", "Moreover, the compounds of the invention maintain a degree of bioactivity as well as bioavailability in comparison to the bioactivity and bioavailability of the compound free of all oligomers.", "With respect to the blood-brain barrier (“BBB”), this barrier restricts the transport of drugs from the blood to the brain.", "This barrier consists of a continuous layer of unique endothelial cells joined by tight junctions.", "The cerebral capillaries, which comprise more than 95% of the total surface area of the BBB, represent the principal route for the entry of most solutes and drugs into the central nervous system.", "For compounds whose degree of blood-brain barrier crossing ability is not readily known, such ability may be determined using a suitable animal model such as an in situ rat brain perfusion (“RBP”) model as described herein.", "Briefly, the RBP technique involves cannulation of the carotid artery followed by perfusion with a compound solution under controlled conditions, followed by a wash out phase to remove compound remaining in the vascular space.", "(Such analyses may be conducted, for example, by contract research organizations such as Absorption Systems, Exton, Pa.).", "In one example of the RBP model, a cannula is placed in the left carotid artery and the side branches are tied off.", "A physiologic buffer containing the analyte (typically but not necessarily at a 5 micromolar concentration level) is perfused at a flow rate of about 10 mL/minute in a single pass perfusion experiment.", "After 30 seconds, the perfusion is stopped and the brain vascular contents are washed out with compound-free buffer for an additional 30 seconds.", "The brain tissue is then removed and analyzed for compound concentrations via liquid chromatography with tandem mass spectrometry detection (LC/MS/MS).", "Alternatively, blood-brain barrier permeability can be estimated based upon a calculation of the compound's molecular polar surface area (“PSA”), which is defined as the sum of surface contributions of polar atoms (usually oxygens, nitrogens and attached hydrogens) in a molecule.", "The PSA has been shown to correlate with compound transport properties such as blood-brain barrier transport.", "Methods for determining a compound's PSA can be found, e.g., Ertl et al.", "(2000) J. Med.", "Chem.", "43:3714-3717 and Kelder et al.", "(1999) Pharm.", "Res.", "16:1514-1519.With respect to the blood-brain barrier, the water-soluble, non-peptidic oligomer-containing compound of the invention exhibits a blood-brain barrier crossing rate that is reduced as compared to the crossing rate of the small molecule drug not attached to the water-soluble, non-peptidic oligomer.", "Exemplary reductions in blood-brain barrier crossing rates for the compounds described herein include reductions of: at least about 5%; at least about 10%; at least about 25%; at least about 30%; at least about 40%; at least about 50%; at least about 60%; at least about 70%; at least about 80%; or at least about 90%, when compared to the blood-brain barrier crossing rate of the corresponding compound lacking water-soluble, non-peptic oligomers.", "A preferred reduction in the blood-brain barrier crossing rate for a conjugate of the invention is at least about 20%.", "Assays for determining whether a given compound (regardless of whether the compound includes a water-soluble, non-peptidic oligomer or not) can act as a 3-alkoxypropionamide are known and/or may be prepared by one of ordinary skill in the art and are further described infra.", "Briefly, one approach for testing whether a given 3-alkoxypropionamide has a decrease in cerebral excitability (as demonstrated by the audiogenic seizure test in mice) is described in Swinyard et al.", "(1963) Procedures International Conference on Psychophysiology, Neuropharmacology, and Biochemistry of Audiogenic Seizures Paris, France: International Colloquium No.", "112:405-427.Using this approach, preferred 3-alkoxypropionamides (and compounds of the invention) will be shown to be active in the tonic phase of the audiogenic seizure at the intraperitoneally administered dose of about 200 mg/kg of body weight.", "Each of these (and other) 3-alkoxypropionamide can be covalently attached (either directly or through one or more atoms) to a water-soluble, non-peptidic oligomer.", "Exemplary molecular weights of a small molecule 3-alkoxypropionamide (prior to, for example, conjugation to a water-soluble, non-peptidic oligomer) include molecular weights of: less than about 950; less than about 900; less than about 850; less than about 800; less than about 750; less than about 700; less than about 650; less than about 600; less than about 550; less than about 500; less than about 450; less than about 400; less than about 350; and less than about 300 Daltons.", "The small molecule drug used in the invention, if chiral, may be obtained from a racemic mixture, or an optically active form, for example, a single optically active enantiomer, or any combination or ratio of enantiomers (e.g., scalemic and racemic mixtures).", "In addition, the small molecule drug may possess one or more geometric isomers.", "With respect to geometric isomers, a composition can comprise a single geometric isomer or a mixture of two or more geometric isomers.", "A small molecule drug for use in the present invention can be in its customary active form, or may possess some degree of modification.", "For example, a small molecule drug may have a targeting agent, tag, or transporter attached thereto, prior to or after covalent attachment of an oligomer.", "Alternatively, the small molecule drug may possess a lipophilic moiety attached thereto, such as a phospholipid (e.g., distearoylphosphatidylethanolamine or “DSPE,” dipalmitoylphosphatidylethanolamine or “DPPE,” and so forth) or a small fatty acid.", "In some instances, however, it is preferred that the small molecule drug moiety does not include attachment to a lipophilic moiety.", "The 3-alkoxypropionamide for coupling to a water-soluble, non-peptidic oligomer possesses a free hydroxyl, carboxyl, thio, amino group, or the like (i.e., “handle”) suitable for covalent attachment to the oligomer.", "In addition, the 3-alkoxypropionamide may be modified by introduction of a reactive group, preferably by conversion of one of its existing functional groups to a functional group suitable for formation of a stable covalent linkage between the oligomer and the drug.", "Each oligomer is composed of up to three different monomer types selected from the group consisting of: alkylene oxide, such as ethylene oxide or propylene oxide; olefinic alcohol, such as vinyl alcohol, 1-propenol or 2-propenol; vinyl pyrrolidone; hydroxyalkyl methacrylamide or hydroxyalkyl methacrylate, where alkyl is preferably methyl; α-hydroxy acid, such as lactic acid or glycolic acid; phosphazene, oxazoline, amino acids, carbohydrates such as monosaccharides, alditol such as mannitol; and N-acryloylmorpholine.", "Preferred monomer types include alkylene oxide, olefinic alcohol, hydroxyalkyl methacrylamide or methacrylate, N-acryloylmorpholine, and α-hydroxy acid.", "Preferably, each oligomer is, independently, a co-oligomer of two monomer types selected from this group, or, more preferably, is a homo-oligomer of one monomer type selected from this group.", "The two monomer types in a co-oligomer may be of the same monomer type, for example, two alkylene oxides, such as ethylene oxide and propylene oxide.", "Preferably, the oligomer is a homo-oligomer of ethylene oxide.", "Usually, although not necessarily, the terminus (or termini) of the oligomer that is not covalently attached to a small molecule is capped to render it unreactive.", "Alternatively, the terminus may include a reactive group.", "When the terminus is a reactive group, the reactive group is either selected such that it is unreactive under the conditions of formation of the final oligomer or during covalent attachment of the oligomer to a small molecule drug, or it is protected as necessary.", "One common end-functional group is hydroxyl or —OH, particularly for oligoethylene oxides.", "The water-soluble, non-peptidic oligomer (e.g., “POLY1” in various structures provided herein) can have any of a number of different geometries.", "For example, the water-soluble, non-peptidic oligomer can be linear, branched, or forked.", "Most typically, the water-soluble, non-peptidic oligomer is linear or is branched, for example, having one branch point.", "Although much of the discussion herein is focused upon poly(ethylene oxide) as an illustrative oligomer, the discussion and structures presented herein can be readily extended to encompass any water-soluble, non-peptidic oligomers described above.", "The molecular weight of the water-soluble, non-peptidic oligomer, excluding the linker portion, is generally relatively low.", "Exemplary values of the molecular weight of the water-soluble polymer include: below about 1500; below about 1450; below about 1400; below about 1350; below about 1300; below about 1250; below about 1200; below about 1150; below about 1100; below about 1050; below about 1000; below about 950; below about 900; below about 850; below about 800; below about 750; below about 700; below about 650; below about 600; below about 550; below about 500; below about 450; below about 400; below about 350; below about 300; below about 250; below about 200; and below about 100 Daltons.", "Exemplary ranges of molecular weights of the water-soluble, non-peptidic oligomer (excluding the linker) include: from about 100 to about 1400 Daltons; from about 100 to about 1200 Daltons; from about 100 to about 800 Daltons; from about 100 to about 500 Daltons; from about 100 to about 400 Daltons; from about 200 to about 500 Daltons; from about 200 to about 400 Daltons; from about 75 to 1000 Daltons; and from about 75 to about 750 Daltons.", "Preferably, the number of monomers in the water-soluble, non-peptidic oligomer falls within one or more of the following ranges: between about 1 and about 30 (inclusive); between about 1 and about 25; between about 1 and about 20; between about 1 and about 15; between about 1 and about 12; between about 1 and about 10.In certain instances, the number of monomers in series in the oligomer (and the corresponding conjugate) is one of 1, 2, 3, 4, 5, 6, 7, or 8.In additional embodiments, the oligomer (and the corresponding conjugate) contains 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 monomers.", "In yet further embodiments, the oligomer (and the corresponding conjugate) possesses 21, 22, 23, 24, 25, 26, 27, 28, 29 or 30 monomers in series.", "Thus, for example, when the water-soluble, non-peptidic polymer includes CH3—(OCH2CH2)n—, “n” is an integer that can be 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 or 30, and can fall within one or more of the following ranges: between about 1 and about 25; between about 1 and about 20; between about 1 and about 15; between about 1 and about 12; between about 1 and about 10.When the water-soluble, non-peptidic oligomer has 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 monomers, these values correspond to a methoxy end-capped oligo(ethylene oxide) having a molecular weights of about 75, 119, 163, 207, 251, 295, 339, 383, 427, and 471 Daltons, respectively.", "When the oligomer has 11, 12, 13, 14, or 15 monomers, these values correspond to methoxy end-capped oligo(ethylene oxide) having molecular weights corresponding to about 515, 559, 603, 647, and 691 Daltons, respectively.", "When the water-soluble, non-peptidic oligomer is attached to the 3-alkoxypropionamide (in contrast to the step-wise addition of one or more monomers to effectively “grow” the oligomer onto the 3-alkoxypropionamide), it is preferred that the composition containing an activated form of the water-soluble, non-peptidic oligomer be monodisperse.", "In those instances, however, where a bimodal composition is employed, the composition will possess a bimodal distribution centering around any two of the above numbers of monomers.", "For instance, a bimodal oligomer may have any one of the following exemplary combinations of monomer subunits: 1-2, 1-3, 1-4, 1-5, 1-6, 1-7, 1-8, 1-9, 1-10, and so forth; 2-3, 2-4, 2-5, 2-6, 2-7, 2-8, 2-9, 2-10, and so forth; 3-4, 3-5, 3-6, 3-7, 3-8, 3-9, 3-10, and so forth; 4-5, 4-6, 4-7, 4-8, 4-9, 4-10, and so forth; 5-6, 5-7, 5-8, 5-9, 5-10, and so forth; 6-7, 6-8, 6-9, 6-10, and so forth; 7-8, 7-9, 7-10, and so forth; and 8-9, 8-10, and so forth.", "In some instances, the composition containing an activated form of the water-soluble, non-peptidic oligomer will be trimodal or even tetramodal, possessing a range of monomers units as previously described.", "Oligomer compositions possessing a well-defined mixture of oligomers (i.e., being bimodal, trimodal, tetramodal, and so forth) can be prepared by mixing purified monodisperse oligomers to obtain a desired profile of oligomers (a mixture of two oligomers differing only in the number of monomers is bimodal; a mixture of three oligomers differing only in the number of monomers is trimodal; a mixture of four oligomers differing only in the number of monomers is tetramodal), or alternatively, can be obtained from column chromatography of a polydisperse oligomer by recovering the “center cut”, to obtain a mixture of oligomers in a desired and defined molecular weight range.", "It is preferred that the water-soluble, non-peptidic oligomer is obtained from a composition that is preferably unimolecular or monodisperse.", "That is, the oligomers in the composition possess the same discrete molecular weight value rather than a distribution of molecular weights.", "Some monodisperse oligomers can be purchased from commercial sources such as those available from Sigma-Aldrich, or alternatively, can be prepared directly from commercially available starting materials such as Sigma-Aldrich.", "Water-soluble, non-peptidic oligomers can be prepared as described in Chen Y., Baker, G. L., J. Org.", "Chem., 6870-6873 (1999), WO 02/098949, and U.S. Patent Application Publication No.", "2005/0136031.The spacer moiety (the linkage through which the water-soluble, non-peptidic polymer is attached to the 3-alkoxypropionamide) may be a single bond, a single atom, such as an oxygen atom or a sulfur atom, two atoms, or a number of atoms.", "A spacer moiety is typically but is not necessarily linear in nature.", "The spacer moiety, “X,” is preferably hydrolytically stable, and is also preferably enzymatically stable.", "Preferably, the spacer moiety “X” is one having a chain length of less than about 12 atoms, and preferably less than about 10 atoms, and even more preferably less than about 8 atoms and even more preferably less than about 5 atoms, whereby length is meant the number of atoms in a single chain, not counting substituents.", "For instance, a urea linkage such as this, Roligomer—NH—(C═O)—NH—R′drug, is considered to have a chain length of 3 atoms (—NH—C(O)—NH—).", "In selected embodiments, the linkage does not comprise further spacer groups.", "In some instances, the spacer moiety (e.g., “X1” in various structures provided herein) comprises an ether, amide, urethane, amine, thioether, urea, or a carbon-carbon bond.", "Functional groups such as those discussed below, and illustrated in the examples, are typically used for forming the linkages.", "The spacer moiety may less preferably also comprise (or be adjacent to or flanked by) other atoms, as described further below.", "More specifically, in selected embodiments, a spacer moiety (e.g., “X1” in various structures provided herein) may be any of the following: “-” (i.e., a covalent bond, that may be stable or degradable, between the pyrrolidine residue and the water-soluble, non-peptidic oligomer), —O—, —NH—, —S—, —C(O)—, —C(O)O—, —OC(O)—, —CH2—C(O)O—, —CH2—OC(O)—, —C(O)O—CH2—, —OC(O)—CH2—, C(O)—NH, NH—C(O)—NH, O—C(O)—NH, —C(S)—, —CH2—, —CH2—CH2—, —CH2—CH2—CH2—, —CH2—CH2—CH2—CH2—, —O—CH2—, —CH2—O—, —O—CH2—CH2—, —CH2—O—CH2—, —CH2—CH2—O—, —O—CH2—CH2—CH2—, —CH2—O—CH2—CH2—, —CH2—CH2—O—CH2—, —CH2—CH2—CH2—O—, —O—CH2—CH2—CH2—CH2—, —CH2—O—CH2—CH2—CH2—, —CH2—CH2—O—CH2—CH2—, —CH2—CH2—CH2—O—CH2—, —CH2—CH2—CH2—CH2—O—, —C(O)—NH—CH2—, —C(O)—NH—CH2—CH2—, —CH2—C(O)—NH—CH2—, —CH2—CH2—C(O)—NH—, —C(O)—NH—CH2—CH2—CH2—, —CH2—C(O)—NH—CH2—CH2—, —CH2—CH2—C(O)—NH—CH2—, —CH2—CH2—CH2—C(O)—NH—, —C(O)—NH—CH2—CH2—CH2—CH2—, —CH2—C(O)—NH—CH2—CH2—CH2—, —CH2—CH2—C(O)—NH—CH2—CH2—, —CH2—CH2—CH2—C(O)—NH—CH2—, —CH2—CH2—CH2—C(O)—NH—CH2—CH2—, —CH2—CH2—CH2—CH2—C(O)—NH—, —NH—C(O)—CH2—, —CH2—NH—C(O)—CH2—, —CH2—CH2—NH—C(O)—CH2—, —NH—C(O)—CH2—CH2—, —CH2—NH—C(O)—CH2—CH2, —CH2—CH2—NH—C(O)—CH2—CH2, —C(O)—NH—CH2—, —C(O)—NH—CH2—CH2—, —O—C(O)—NH—CH2—, —O—C(O)—NH—CH2—CH2—, —NH—CH2—, —NH—CH2—CH2—, —CH2—NH—CH2—, —CH2—CH2—NH—CH2—, —C(O)—CH2—, —C(O)—CH2—CH2—, —CH2—C(O)—CH2—, —CH2—CH2—C(O)—CH2—, —CH2—CH2—C(O)—CH2—CH2—, —CH2—CH2—C(O)—, —CH2—CH2—CH2—C(O)—NH—CH2—CH2—NH—, —CH2—CH2—CH2—C(O)—NH—CH2—CH2—NH—C(O)—, —CH2—CH2—CH2—C(O)—NH—CH2—CH2—NH—C(O)—CH2—, bivalent cycloalkyl group, —N(R6)—, R6 is H or an organic radical selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl and substituted aryl.", "Additional spacer moieties include, acylamino, acyl, aryloxy, alkylene bridge containing between 1 and 5 inclusive carbon atoms, alkylamino, dialkylamino having about 2 to 4 inclusive carbon atoms, piperidino, pyrrolidino, N-(lower alkyl)-2-piperidyl, morpholino, 1-piperizinyl, 4-(lower alkyl)-1-piperizinyl, 4-(hydroxyl-lower alkyl)-1-piperizinyl, 4-(methoxy-lower alkyl)-1-piperizinyl, and guanidine.", "In some instances, a portion or a functional group of the drug compound may be modified or removed altogether to facilitate attachment of the oligomer.", "For purposes of the present invention, however, a group of atoms is not considered a linkage when it is immediately adjacent to an oligomer segment, and the group of atoms is the same as a monomer of the oligomer such that the group would represent a mere extension of the oligomer chain.", "The spacer moiety between the water-soluble, non-peptidic oligomer and the small molecule is formed by reaction of a functional group on a terminus of the oligomer (or nascent oligomer when it is desired to “grow” the oligomer onto the pyrrolidine) with a corresponding functional group within the pyrrolidine.", "Illustrative reactions are described briefly below.", "For example, an amino group on an oligomer may be reacted with a carboxylic acid or an activated carboxylic acid derivative on the small molecule, or vice versa, to produce an amide linkage.", "Alternatively, reaction of an amine on an oligomer with an activated carbonate (e.g., succinimidyl or benzotriazolyl carbonate) on the drug, or vice versa, forms a carbamate linkage.", "Reaction of an amine on an oligomer with an isocyanate (R—N═C═O) on a drug, or vice versa, forms a urea linkage (R—NH—(C═O)—NH—R′).", "Further, reaction of an alcohol (alkoxide) group on an oligomer with an alkyl halide, or halide group within a drug, or vice versa, forms an ether linkage.", "In yet another coupling approach, a small molecule having an aldehyde function is coupled to an oligomer amino group by reductive amination, resulting in formation of a secondary amine linkage between the oligomer and the small molecule.", "A particularly preferred water-soluble, non-peptidic oligomer is an oligomer bearing an aldehyde functional group.", "In this regard, the oligomer will have the following structure: CH3O—(CH2—CH2—O)n—(CH2)p—C(O)H, wherein (n) is one of 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10 and (p) is one of 1, 2, 3, 4, 5, 6 and 7.Preferred (n) values include 3, 5 and 7 and preferred (p) values 2, 3 and 4.The termini of the water-soluble, non-peptidic oligomer not bearing a functional group may be capped to render it unreactive.", "When the oligomer includes a further functional group at a terminus other than that intended for formation of a conjugate, that group is either selected such that it is unreactive under the conditions of formation of the spacer moiety (e.g., “X”) or it is protected during the formation of the spacer moiety (e.g., “X1”).", "As stated above, the water-soluble, non-peptidic oligomer includes at least one functional group prior to conjugation.", "The functional group comprises an electrophilic or nucleophilic group for covalent attachment to a small molecule, depending upon the reactive group contained within or introduced into the small molecule.", "Examples of nucleophilic groups that may be present in either the oligomer or the small molecule include hydroxyl, amine, hydrazine (—NHNH2), hydrazide (—C(O)NHNH2), and thiol.", "Preferred nucleophiles include amine, hydrazine, hydrazide, and thiol, particularly amine.", "Most small molecule drugs for covalent attachment to an oligomer will possess a free hydroxyl, amino, thio, aldehyde, ketone, or carboxyl group.", "Examples of electrophilic functional groups that may be present in either the oligomer or the small molecule include carboxylic acid, carboxylic ester, particularly imide esters, orthoester, carbonate, isocyanate, isothiocyanate, aldehyde, ketone, thione, alkenyl, acrylate, methacrylate, acrylamide, sulfone, maleimide, disulfide, iodo, epoxy, sulfonate, thiosulfonate, silane, alkoxysilane, and halosilane.", "More specific examples of these groups include succinimidyl ester or carbonate, imidazoyl ester or carbonate, benzotriazole ester or carbonate, vinyl sulfone, chloroethylsulfone, vinylpyridine, pyridyl disulfide, iodoacetamide, glyoxal, dione, mesylate, tosylate, and tresylate (2,2,2-trifluoroethanesulfonate).", "Also included are sulfur analogs of several of these groups, such as thione, thione hydrate, thioketal, 2-thiazolidine thione, etc., as well as hydrates or protected derivatives of any of the above moieties (e.g., aldehyde hydrate, hemiacetal, acetal, ketone hydrate, hemiketal, ketal, thioketal, thioacetal).", "An “activated derivative” of a carboxylic acid refers to a carboxylic acid derivative that reacts readily with nucleophiles, generally much more readily than the underivatized carboxylic acid.", "Activated carboxylic acids include, for example, acid halides (such as acid chlorides), anhydrides, carbonates, and esters.", "Such esters include imide esters, of the general form —(CO)O—N[(CO)—]2; for example, N-hydroxysuccinimidyl (NHS) esters or N-hydroxyphthalimidyl esters.", "Also preferred are imidazolyl esters and benzotriazole esters.", "Particularly preferred are activated propionic acid or butanoic acid esters, as described in co-owned U.S. Pat.", "No.", "5,672,662.These include groups of the form —(CH2)2-3C(═O)O-Q, where Q is preferably selected from N-succinimide, N-sulfosuccinimide, N-phthalimide, N-glutarimide, N-tetrahydrophthalimide, N-norbornene-2,3-dicarboximide, benzotriazole, 7-azabenzotriazole, and imidazole.", "Other preferred electrophilic groups include succinimidyl carbonate, maleimide, benzotriazole carbonate, glycidyl ether, imidazoyl carbonate, p-nitrophenyl carbonate, acrylate, tresylate, aldehyde, and orthopyridyl disulfide.", "These electrophilic groups are subject to reaction with nucleophiles, e.g., hydroxy, thio, or amino groups, to produce various bond types.", "Preferred for the present invention are reactions which favor formation of a hydrolytically stable linkage.", "For example, carboxylic acids and activated derivatives thereof, which include orthoesters, succinimidyl esters, imidazolyl esters, and benzotriazole esters, react with the above types of nucleophiles to form esters, thioesters, and amides, respectively, of which amides are the most hydrolytically stable.", "Carbonates, including succinimidyl, imidazolyl, and benzotriazole carbonates, react with amino groups to form carbamates.", "Isocyanates (R—N═C═O) react with hydroxyl or amino groups to form, respectively, carbamate (RNH—C(O)—OR′) or urea (RNH—C(O)—NHR′) linkages.", "Aldehydes, ketones, glyoxals, diones and their hydrates or alcohol adducts (i.e., aldehyde hydrate, hemiacetal, acetal, ketone hydrate, hemiketal, and ketal) are preferably reacted with amines, followed by reduction of the resulting imine, if desired, to provide an amine linkage (reductive amination).", "Several of the electrophilic functional groups include electrophilic double bonds to which nucleophilic groups, such as thiols, can be added, to form, for example, thioether bonds.", "These groups include maleimides, vinyl sulfones, vinyl pyridine, acrylates, methacrylates, and acrylamides.", "Other groups comprise leaving groups that can be displaced by a nucleophile; these include chloroethyl sulfone, pyridyl disulfides (which include a cleavable S—S bond), iodoacetamide, mesylate, tosylate, thiosulfonate, and tresylate.", "Epoxides react by ring opening by a nucleophile, to form, for example, an ether or amine bond.", "Reactions involving complementary reactive groups such as those noted above on the oligomer and the small molecule are utilized to prepare the conjugates of the invention.", "In some instances the 3-alkoxypropionamide may not have a functional group suited for conjugation.", "In this instance, it is possible to modify (or “functionalize”) the “original” 3-alkoxypropionamide so that it does have a functional group suited for conjugation.", "For example, if the 3-alkoxypropionamide has an amide group, but an amine group is desired, it is possible to modify the amide group to an amine group by way of a Hofmann rearrangement, Curtius rearrangement (once the amide is converted to an azide) or Lossen rearrangement (once amide is concerted to hydroxamide followed by treatment with tolyene-2-sulfonyl chloride/base).", "It is possible to prepare a conjugate of 3-alkoxypropionamide bearing a carboxyl group wherein the carboxyl group-bearing 3-alkoxypropionamide is coupled to an amino-terminated oligomeric ethylene glycol, to provide a conjugate having an amide group covalently linking the 3-alkoxypropionamide to the oligomer.", "This can be performed, for example, by combining the carboxyl group-bearing 3-alkoxypropionamide with the amino-terminated oligomeric ethylene glycol in the presence of a coupling reagent, (such as dicyclohexylcarbodiimide or “DCC”) in an anhydrous organic solvent.", "Further, it is possible to prepare a conjugate of a 3-alkoxypropionamide bearing a hydroxyl group wherein the hydroxyl group-bearing 3-alkoxypropionamide is coupled to an oligomeric ethylene glycol halide to result in an ether (—O—) linked conjugate.", "This can be performed, for example, by using sodium hydride to deprotonate the hydroxyl group followed by reaction with a halide-terminated oligomeric ethylene glycol.", "Further, it is possible to prepare a conjugate of a 3-alkoxypropionamide bearing a hydroxyl group wherein the hydroxyl group-bearing 3-alkoxypropionamide is coupled to an oligomeric ethylene glycol bearing an haloformate group [e.g., CH3(OCH2CH2)nOC(O)-halo, where halo is chloro, bromo, iodo] to result in a carbonate [—O—C(O)—O—] linked small molecule conjugate.", "This can be performed, for example, by combining a 3-alkoxypropionamide and an oligomeric ethylene glycol bearing a haloformate group in the presence of a nucleophilic catalyst (such as 4-dimethylaminopyridine or “DMAP”) to thereby result in the corresponding carbonate-linked conjugate.", "In another example, it is possible to prepare a conjugate of a 3-alkoxypropionamide bearing a ketone group by first reducing the ketone group to form the corresponding hydroxyl group.", "Thereafter, the 3-alkoxypropionamide now bearing a hydroxyl group can be coupled as described herein.", "In still another instance, it is possible to prepare a conjugate of a 3-alkoxypropionamide bearing an amine group.", "In one approach, the amine group-bearing 3-alkoxypropionamide and an aldehyde-bearing oligomer are dissolved in a suitable buffer after which a suitable reducing agent (e.g., NaCNBH3) is added.", "Following reduction, the result is an amine linkage formed between the amine group of the amine group-containing 3-alkoxypropionamide and the carbonyl carbon of the aldehyde-bearing oligomer.", "In another approach for preparing a conjugate of a 3-alkoxypropionamide bearing an amine group, a carboxylic acid-bearing oligomer and the amine group-bearing 3-alkoxypropionamide are combined, in the presence of a coupling reagent (e.g., DCC).", "The result is an amide linkage formed between the amine group of the amine group-containing 3-alkoxypropionamide and the carbonyl of the carboxylic acid-bearing oligomer.", "While it is believed that the full scope of the compounds disclosed herein behave as described, an optimally sized oligomer can be identified as follows.", "First, an oligomer obtained from a monodisperse or bimodal water soluble oligomer is conjugated to the 3-alkoxypropionamide.", "Preferably, the drug is orally bioavailable, and on its own, exhibits a non-negligible blood-brain barrier crossing rate.", "Next, the ability of the conjugate to cross the blood-brain barrier is determined using an appropriate model and compared to that of the unmodified parent drug.", "If the results are favorable, that is to say, if, for example, the rate of crossing is significantly reduced, then the bioactivity of conjugate is further evaluated.", "Preferably, the compounds according to the invention maintain a significant degree of bioactivity relative to the parent drug, i.e., greater than about 30% of the bioactivity of the parent drug, or even more preferably, greater than about 50% of the bioactivity of the parent drug.", "The above steps are repeated one or more times using oligomers of the same monomer type but having a different number of subunits and the results compared.", "For each conjugate whose ability to cross the blood-brain barrier is reduced in comparison to the non-conjugated small molecule drug, its oral bioavailability is then assessed.", "Based upon these results, that is to say, based upon the comparison of conjugates of oligomers of varying size to a given small molecule at a given position or location within the small molecule, it is possible to determine the size of the oligomer most effective in providing a conjugate having an optimal balance between reduction in biological membrane crossing, oral bioavailability, and bioactivity.", "The small size of the oligomers makes such screenings feasible and allows one to effectively tailor the properties of the resulting conjugate.", "By making small, incremental changes in oligomer size and utilizing an experimental design approach, one can effectively identify a conjugate having a favorable balance of reduction in biological membrane crossing rate, bioactivity, and oral bioavailability.", "In some instances, attachment of an oligomer as described herein is effective to actually increase oral bioavailability of the drug.", "For example, one of ordinary skill in the art, using routine experimentation, can determine a best suited molecular size and linkage for improving oral bioavailability by first preparing a series of oligomers with different weights and functional groups and then obtaining the necessary clearance profiles by administering the conjugates to a patient and taking periodic blood and/or urine sampling.", "Once a series of clearance profiles have been obtained for each tested conjugate, a suitable conjugate can be identified.", "Animal models (rodents and dogs) can also be used to study oral drug transport.", "In addition, non-in vivo methods include rodent everted gut excised tissue and Caco-2 cell monolayer tissue-culture models.", "These models are useful in predicting oral drug bioavailability.", "To determine whether the 3-alkoxypropionamide or a compound of the invention (e.g., a conjugate of a 3-alkoxypropionamide and a water-soluble, non-peptidic oligomer) has activity as a 3-alkoxypropionamide therapeutic, it is possible to test such a compound.", "The compound of interest may be tested using in vitro binding studies to receptors using various cell lines expressing these receptors that have become routine in pharmaceutical industry and described herein.", "The compounds of the invention may be administered per se or in the form of a pharmaceutically acceptable salt, and any reference to the compounds of the invention herein is intended to include pharmaceutically acceptable salts.", "If used, a salt of a compound as described herein should be both pharmacologically and pharmaceutically acceptable, but non-pharmaceutically acceptable salts may conveniently be used to prepare the free active compound or pharmaceutically acceptable salts thereof and are not excluded from the scope of this invention.", "Such pharmacologically and pharmaceutically acceptable salts can be prepared by reaction of the compound with an organic or inorganic acid, using standard methods detailed in the literature.", "Examples of useful salts include, but are not limited to, those prepared from the following acids: hydrochloric, hydrobromic, sulfuric, nitric, phosphoric, maleic, acetic, salicyclic, p-toluenesulfonic, tartaric, citric, methanesulfonic, formic, malonic, succinic, naphthalene-2-sulphonic and benzenesulphonic, and the like.", "Also, pharmaceutically acceptable salts can be prepared as alkaline metal or alkaline earth salts, such as sodium, potassium, or calcium salts of a carboxylic acid group.", "The present invention also includes pharmaceutical preparations comprising a compound as provided herein in combination with a pharmaceutical excipient.", "Generally, the compound itself will be in a solid form (e.g., a precipitate), which can be combined with a suitable pharmaceutical excipient that can be in either solid or liquid form.", "Exemplary excipients include, without limitation, those selected from the group consisting of carbohydrates, inorganic salts, antimicrobial agents, antioxidants, surfactants, buffers, acids, bases, and combinations thereof.", "A carbohydrate such as a sugar, a derivatized sugar such as an alditol, aldonic acid, an esterified sugar, and/or a sugar polymer may be present as an excipient.", "Specific carbohydrate excipients include, for example: monosaccharides, such as fructose, maltose, galactose, glucose, D-mannose, sorbose, and the like; disaccharides, such as lactose, sucrose, trehalose, cellobiose, and the like; polysaccharides, such as raffinose, melezitose, maltodextrins, dextrans, starches, and the like; and alditols, such as mannitol, maltitol, lactitol, xylitol, sorbitol, myoinositol, and the like.", "The excipient can also include an inorganic salt or buffer such as citric acid, sodium chloride, potassium chloride, sodium sulfate, potassium nitrate, sodium phosphate monobasic, sodium phosphate dibasic, and combinations thereof.", "The preparation may also include an antimicrobial agent for preventing or deterring microbial growth.", "Nonlimiting examples of antimicrobial agents suitable for the present invention include benzalkonium chloride, benzethonium chloride, benzyl alcohol, cetylpyridinium chloride, chlorobutanol, phenol, phenylethyl alcohol, phenylmercuric nitrate, thimersol, and combinations thereof.", "An antioxidant can be present in the preparation as well.", "Antioxidants are used to prevent oxidation, thereby preventing the deterioration of the conjugate or other components of the preparation.", "Suitable antioxidants for use in the present invention include, for example, ascorbyl palmitate, butylated hydroxyanisole, butylated hydroxytoluene, hypophosphorous acid, monothioglycerol, propyl gallate, sodium bisulfite, sodium formaldehyde sulfoxylate, sodium metabisulfite, and combinations thereof.", "A surfactant may be present as an excipient.", "Exemplary surfactants include: polysorbates, such as “Tween 20” and “Tween 80,” and pluronics such as F68 and F88 (both of which are available from BASF, Mount Olive, N.J.); sorbitan esters; lipids, such as phospholipids such as lecithin and other phosphatidylcholines, phosphatidylethanolamines, fatty acids and fatty esters; steroids, such as cholesterol; and chelating agents, such as EDTA, zinc and other such suitable cations.", "Pharmaceutically acceptable acids or bases may be present as an excipient in the preparation.", "Nonlimiting examples of acids that can be used include those acids selected from the group consisting of hydrochloric acid, acetic acid, phosphoric acid, citric acid, malic acid, lactic acid, formic acid, trichloroacetic acid, nitric acid, perchloric acid, phosphoric acid, sulfuric acid, fumaric acid, and combinations thereof.", "Examples of suitable bases include, without limitation, bases selected from the group consisting of sodium hydroxide, sodium acetate, ammonium hydroxide, potassium hydroxide, ammonium acetate, potassium acetate, sodium phosphate, potassium phosphate, sodium citrate, sodium formate, sodium sulfate, potassium sulfate, potassium fumerate, and combinations thereof.", "The amount of the compound of the invention in the composition will vary depending on a number of factors, but will optimally be a therapeutically effective dose when the composition is stored in a unit dose container.", "A therapeutically effective dose can be determined experimentally by repeated administration of increasing amounts of the compound in order to determine which amount produces a clinically desired endpoint.", "The amount of any individual excipient in the composition will vary depending on the activity of the excipient and particular needs of the composition.", "The optimal amount of any individual excipient is determined through routine experimentation, i.e., by preparing compositions containing varying amounts of the excipient (ranging from low to high), examining the stability and other parameters, and then determining the range at which optimal performance is attained with no significant adverse effects.", "Generally, however, excipients will be present in the composition in an amount of about 1% to about 99% by weight, preferably from about 5%-98% by weight, more preferably from about 15-95% by weight of the excipient, with concentrations less than 30% by weight most preferred.", "These foregoing pharmaceutical excipients along with other excipients and general teachings regarding pharmaceutical compositions are described in “Remington: The Science & Practice of Pharmacy”, 19th ed., Williams & Williams, (1995), the “Physician's Desk Reference”, 52nd ed., Medical Economics, Montvale, N.J. (1998), and Kibbe, A. H., Handbook of Pharmaceutical Excipients, 3rd Edition, American Pharmaceutical Association, Washington, D.C., 2000.The pharmaceutical compositions can take any number of forms and the invention is not limited in this regard.", "Exemplary preparations are most preferably in a form suitable for oral administration such as a tablet, caplet, capsule, gel cap, troche, dispersion, suspension, solution, elixir, syrup, lozenge, transdermal patch, spray, suppository, and powder.", "Oral dosage forms are preferred for those conjugates that are orally active, and include tablets, caplets, capsules, gel caps, suspensions, solutions, elixirs, and syrups, and can also comprise a plurality of granules, beads, powders or pellets that are optionally encapsulated.", "Such dosage forms are prepared using conventional methods known to those in the field of pharmaceutical formulation and described in the pertinent texts.", "Tablets and caplets, for example, can be manufactured using standard tablet processing procedures and equipment.", "Direct compression and granulation techniques are preferred when preparing tablets or caplets containing the conjugates described herein.", "In addition to the conjugate, the tablets and caplets will generally contain inactive, pharmaceutically acceptable carrier materials such as binders, lubricants, disintegrants, fillers, stabilizers, surfactants, coloring agents, flow agents, and the like.", "Binders are used to impart cohesive qualities to a tablet, and thus ensure that the tablet remains intact.", "Suitable binder materials include, but are not limited to, starch (including corn starch and pregelatinized starch), gelatin, sugars (including sucrose, glucose, dextrose and lactose), polyethylene glycol, waxes, and natural and synthetic gums, e.g., acacia sodium alginate, polyvinylpyrrolidone, cellulosic polymers (including hydroxypropyl cellulose, hydroxypropyl methylcellulose, methyl cellulose, microcrystalline cellulose, ethyl cellulose, hydroxyethylcellulose, and the like), and Veegum.", "Lubricants are used to facilitate tablet manufacture, promoting powder flow and preventing particle capping (i.e., particle breakage) when pressure is relieved.", "Useful lubricants are magnesium stearate, calcium stearate, and stearic acid.", "Disintegrants are used to facilitate disintegration of the tablet, and are generally starches, clays, celluloses, algins, gums, or crosslinked polymers.", "Fillers include, for example, materials such as silicon dioxide, titanium dioxide, alumina, talc, kaolin, powdered cellulose, and microcrystalline cellulose, as well as soluble materials such as mannitol, urea, sucrose, lactose, dextrose, sodium chloride, and sorbitol.", "Stabilizers, as well known in the art, are used to inhibit or retard drug decomposition reactions that include, by way of example, oxidative reactions.", "Capsules are also preferred oral dosage forms, in which case the conjugate-containing composition can be encapsulated in the form of a liquid or gel (e.g., in the case of a gel cap) or solid (including particulates such as granules, beads, powders or pellets).", "Suitable capsules include hard and soft capsules, and are generally made of gelatin, starch, or a cellulosic material.", "Two-piece hard gelatin capsules are preferably sealed, such as with gelatin bands or the like.", "Included are parenteral formulations in the substantially dry form (as a lyophilizate or precipitate, which can be in the form of a powder or cake), as well as formulations prepared for injection, which are liquid and require the step of reconstituting the dry form of parenteral formulation.", "Examples of suitable diluents for reconstituting solid compositions prior to injection include bacteriostatic water for injection, dextrose 5% in water, phosphate-buffered saline, Ringer's solution, saline, sterile water, deionized water, and combinations thereof.", "In some cases, compositions intended for parenteral administration can take the form of nonaqueous solutions, suspensions, or emulsions, normally being sterile.", "Examples of nonaqueous solvents or vehicles are propylene glycol, polyethylene glycol, vegetable oils, such as olive oil and corn oil, gelatin, and injectable organic esters such as ethyl oleate.", "The parenteral formulations described herein can also contain adjuvants such as preserving, wetting, emulsifying, and dispersing agents.", "The formulations are rendered sterile by incorporation of a sterilizing agent, filtration through a bacteria-retaining filter, irradiation, or heat.", "The compounds of the invention can also be administered through the skin using conventional transdermal patch or other transdermal delivery system, wherein the conjugate is contained within a laminated structure that serves as a drug delivery device to be affixed to the skin.", "In such a structure, the compound is contained in a layer, or “reservoir,” underlying an upper backing layer.", "The laminated structure can contain a single reservoir, or it can contain multiple reservoirs.", "The compounds of the invention can also be formulated into a suppository for rectal administration.", "With respect to suppositories, the compound is mixed with a suppository base material which is (e.g., an excipient that remains solid at room temperature but softens, melts or dissolves at body temperature) such as cocoa butter (theobroma oil), polyethylene glycols, glycerinated gelatin, fatty acids, and combinations thereof.", "Suppositories can be prepared by, for example, performing the following steps (not necessarily in the order presented): melting the suppository base material to form a melt; incorporating the compound (either before or after melting of the suppository base material); pouring the melt into a mold; cooling the melt (e.g., placing the melt-containing mold in a room temperature environment) to thereby form suppositories; and removing the suppositories from the mold.", "In some embodiments of the invention, the compositions comprising the compounds of the invention may further be incorporated into a suitable delivery vehicle.", "Such delivery vehicles may provide controlled and/or continuous release of the compounds and may also serve as a targeting moiety.", "Non-limiting examples of delivery vehicles include, adjuvants, synthetic adjuvants, microcapsules, microparticles, liposomes, and yeast cell wall particles.", "Yeast cells walls may be variously processed to selectively remove protein component, glucan, or mannan layers, and are referred to as whole glucan particles (WGP), yeast beta-glucan mannan particles (YGMP), yeast glucan particles (YGP), Rhodotorula yeast cell particles (YCP).", "Yeast cells such as S. cerevisiae and Rhodotorula species are preferred; however, any yeast cell may be used.", "These yeast cells exhibit different properties in terms of hydrodynamic volume and also differ in the target organ where they may release their contents.", "The methods of manufacture and characterization of these particles are described in U.S. Pat.", "Nos.", "5,741,495, 4,810,646, 4,992,540, 5,028,703 and 5,607,677, and U.S. Patent Application Publication Nos.", "2005/0281781 and 2008/0044438.The invention also provides a method for administering a compound of the invention as provided herein to a patient suffering from a condition that is responsive to treatment with the compound.", "The method comprises administering, generally orally, a therapeutically effective amount of the compound (preferably provided as part of a pharmaceutical preparation).", "Other modes of administration are also contemplated, such as pulmonary, nasal, buccal, rectal, sublingual, transdermal, and parenteral.", "As used herein, the term “parenteral” includes subcutaneous, intravenous, intra-arterial, intraperitoneal, intracardiac, intrathecal, and intramuscular injection, as well as infusion injections.", "In instances where parenteral administration is utilized, it may be necessary to employ somewhat bigger oligomers than those described previously, with molecular weights ranging from about 500 to 30K Daltons (e.g., having molecular weights of about 500, 1000, 2000, 2500, 3000, 5000, 7500, 10000, 15000, 20000, 25000, 30000 or even more).", "The method of administering may be used to treat any condition that can be remedied or prevented by administration of a particular compound of the invention.", "Those of ordinary skill in the art appreciate which conditions a specific compound can effectively treat.", "Exemplary conditions include epileptic conditions and pain (e.g., neuropathic pain).", "The actual dose to be administered will vary depend upon the age, weight, and general condition of the subject as well as the severity of the condition being treated, the judgment of the health care professional, and conjugate being administered.", "Therapeutically effective amounts are known to those skilled in the art and/or are described in the pertinent reference texts and literature.", "Generally, a therapeutically effective amount will range from about 0.001 mg to 1000 mg, preferably in doses from 0.01 mg/day to 750 mg/day, and more preferably in doses from 0.10 mg/day to 500 mg/day.", "The unit dosage of any given compound of the invention (again, preferably provided as part of a pharmaceutical preparation) can be administered in a variety of dosing schedules depending on the judgment of the clinician, needs of the patient, and so forth.", "The specific dosing schedule will be known by those of ordinary skill in the art or can be determined experimentally using routine methods.", "Exemplary dosing schedules include, without limitation, administration five times a day, four times a day, three times a day, twice daily, once daily, three times weekly, twice weekly, once weekly, twice monthly, once monthly, and any combination thereof.", "Once the clinical endpoint has been achieved, dosing of the composition is halted.", "All articles, books, patents, patent publications and other publications referenced herein are incorporated by reference in their entireties.", "In the event of an inconsistency between the teachings of this specification and the art incorporated by reference, the meaning of the teachings and definitions in this specification shall prevail (particularly with respect to terms used in the claims appended herein).", "For example, where the present application and a publication incorporated by reference defines the same term differently, the definition of the term shall be preserved within the teachings of the document from which the definition is located.", "EXPERIMENTAL It is to be understood that while the invention has been described in conjunction with certain preferred and specific embodiments, the foregoing description as well as the examples that follow are intended to illustrate and not limit the scope of the invention.", "Other aspects, advantages and modifications within the scope of the invention will be apparent to those skilled in the art to which the invention pertains.", "All non-PEG chemical reagents referred to in the appended examples are commercially available unless otherwise indicated.", "The preparation of PEG-mers is described in, for example, U.S. Patent Application Publication No.", "2005/0136031.1H NMR (nuclear magnetic resonance) data was generated by an NMR spectrometer.", "Example 1 Synthesis of N-Optionally Substituted Aryl-2-Oligomer-3-Alkoxypropionamides An exemplary approach for preparing the N-optionally substituted aryl-2-oligomer-3-alkoxypropionamide, (2R) N-benzyl-2-carboxy mPEGn amino-3-methoxy propionamide is provided in the schematic below.", "Synthesis of (R)-2-N-Boc-amino-3-methoxypropanoic acid A suspension of N-Boc-D-serine (17.6 g, 86 mmol) and tetrabutylammonium bromide (1.04 g, 3.23 mmol) in toluene (90 mL) was cooled with an ice-bath with stirring.", "To the reaction mixture was added 20% sodium hydroxide (14 mL, 86 mmol) and the resulting mixture was stirred for thirty minutes.", "Dimethyl sulphate (43.3 g, 343 mmol) and 50% sodium hydroxide (20.3 mL, 388 mmol) were added and the reaction mixture was stirred at <10° C. for 3 hours.", "Water (60 ml) was then added to the mixture and the resulting two phases were separated.", "The aqueous phase was washed with dichloromethane (100 mL×2).", "The aqueous phase was then acidified to a pH of <3.5 with 50% citric acid and extracted with methylene chloride (100 mL×3).", "The organic phases were combined, dried over sodium sulfate, filtered, and solvent removed under reduced pressure to afford a colorless oil (15.6 g, yield: 83%, purity >95%).", "1H NMR (500 MHz, CDCl3) δ 1.45 (s, 9H), 3.37 (s, 3H), 3.62 (m, 1H), 3.85 (m, 1H), 4.43 (m, 1H), 5.42 (d, 1H).", "LC-MS (m/z) calculated 219.1, found 242.0 [M+Na]+.", "Synthesis of (R)—N-Benzyl-2-Boc-amino-3-methoxypropionamide (R)-2-N-Boc-amino-3-methoxypropanoic acid (15.0 g, 68.4 mmol), phenylmethanamine (7.33 g, 68.4 mmol), and DMAP (4.17 g, 34.2 mmol) were dissolved in DCM (150 mL).", "The solution was cooled in an ice-bath and EDC (21.21 g, 137 mmol) was added dropwise to the solution.", "Once addition was complete, the reaction mixture was stirred at warmed to room temperature and stirred for two hours.", "Then DCM (200 ml) was added to the mixture.", "The DCM organic phase was washed with H2O (200 mL×1), 0.5 N HCl (200 mL×2), 5% sodium bicarbonate (200 mL×2) and water (200 mL×2).", "The organic phase was dried over sodium sulfate, filtered, and solvent removed under reduced pressure.", "The desired product was obtained as a colorless semi-solid with a purity >95% (9.8 g, 46.4%).", "1H NMR (500 MHz, CDCl3) δ 1.46 (s, 9H), 3.38 (s, 3H), 3.51 (m, 1H), 3.86 (d, 1H), 4.30 (br., 1H), 4.50 (s, 2H), 5.42 (br., 1H), 6.74 (br., 1H), 7.28 (m, 3H), 7.35 (m, 2H).", "LC-MS (m/z) calculated.", "308.2, found 309.1 [M+H]+, 331.1 [M+Na]+.", "Synthesis of (R)-2-amino-N-benzyl-3-methoxypropanamide (R)—N— benzyl-2-Boc-amino-3-methoxypropanamide (9.8 g, 31.8 mmol) was dissolved in 15 mL of DCM and then 15 mL of TFA was added to the solution.", "The mixture was stirred at room temperature for two hours.", "The solvent and TFA was removed by evaporation and a white solid was obtained (12.4, 100%).", "Upon analysis, it was determined that on average each molecule contained 1.6 TFA.", "1H NMR (500 MHz, DMSO) δ 3.30 (s, 3H), 3.69 (m, 2H), 4.05 (m, 1H), 4.35 (m, 2H), 7.25 (m, 3H), 7.35 (m, 2H), 8.23 (br., 2H), 8.95 (m, 1H).", "LC-MS (m/z) calcd.", "208.1, found 209.1 [M+H]+.", "Synthesis of Lacosamide A solution of acetic anhydride (262 mg, 2.56 mmol) and (R)-2-amino-N-benzyl-3-methoxypropanamide 1.6 TFA (1000 mg, 2.56 mmol) in 10 mL of DCM and triethylamine (3.6 mL, 25.6 mmol) was added.", "The resulting solution was stirred at room temperature for three hours.", "DCM (200 mL) was added to the reaction mixture.", "The resulting solution was washed with H2O (200 mL), 0.2 N HCl (100 mL), 5% NaHCO3 (100 mL), and then H2O (100 mL) and dried over Na2SO4.A white solid was obtained after the solvent was removed under reduced pressure.", "The crude product was purified by crystallization from ethyl acetate/hexane (1:1).", "The desired product was obtained with a purity of 99% (220 mg, yield: 33.0%).", "1H NMR (500 MHz, CDCl3) δ 2.05 (s, 3H).", "3.39 (s, 3H), 3.45 (t, 1H), 3.84 (m, 1H), 4.48 (s, 2H), 4.56 (m, 1H), 6.44 (br., 1H).", "6.74 (br., 1H), 7.28 (m, 3H), 7.36 (m, 2H).", "LC-MS (m/z) calculated 250.1, found 251.1 [M+H]+, 273.1 [M+Na]+.", "General procedure for the syntheses of (2R) N-benzyl-2-carboxy mPEGn amino-3-methoxy propionamide (n=1, 2, 3, 4, 5, 6, 7, 8, 9).", "To a solution of mPEGn-OH (3.0 mmol, n=1, 2, 3, 4, 5, 6, 7, 8, or 9) and N,N-disuccinimidyl carbonate (1150 mg, 4.5 mmol) in 10 mL of CH3CN was added triethylamine (1.25 mL, 9.0 mmol).", "The resulting solution was stirred at room temperature for three hours (complete conversion, monitored by HPLC).", "After the reaction was completed, 100 mL of DCM was added to the reaction mixture.", "The solution was washed with 5% of NaHCO3 (50 mL×2) and then with water.", "The DCM organic phase was then dried, filtered, and the solvent removed under reduced pressure.", "The product, (mPEGn-succinimidyl carbonate), was obtained as a colorless oil (yields, 80-90%) and was used in the following reactions without further purification.", "To a solution of mPEGn-succinimidyl carbonate (2.0 mmol, n=1, 2, 3, 4, 5, 6, 7, 8, or 9) and (R)-2-amino-N-benzyl-3-methoxypropanamide 1.6 TFA (780 mg, 2.0 mmol) in 20 mL of DCM was added triethylamine (2.79 mL, 20.0 mmol).", "The reaction solution was stirred at room temperature for three hours.", "Dichloromethane (200 mL) was then added to the reaction mixture and the resulting solution was washed with H2O (200 mL), 0.2 N HCl (100 mL), 5% NaHCO3 (100 mL), and then H2O (100 mL).", "The organic phase was dried over Na2SO4, filtered, and the solvent removed under reduced pressure.", "The desired product was obtained as a colorless oil (or white solid for n=1, 2, 3) which was then purified by Biotage flash chromatography [MeOH/DCM, 3% MeOH (eq.", "), 3-5% MeOH, 15 CV, 5% MeOH, 5 CV].", "The products, (2R) N-benzyl-2-carboxy mPEGn amino-3-methoxy propionamide (n=1, 2, 3, 4, 5, 6, 7, 8, or 9), were obtained with purities of 97-99%) and yields, 40-65%.", "(2R) N-benzyl-2-carboxy mPEG1 amino-3-methoxy propionamide: 1H NMR (500 MHz, CDCl3) δ 3.38 (s, 3H), 3.39 (s, 3H), 3.50 (m, 1H), 3.59 (m, 2H), 3.90 (m, 1H), 4.25 (m, 2H), 4.35 (br., 1H).", "4.50 (m, 2H), 5.73 (br., 1H), 6.72 (br., 1H), 7.28 (m, 3H), 7.36 (m, 2H).", "LC-MS (m/z) calculated 310.1; found, 311.1 [M+H]+, 333.1 [M+Na]+.", "(2R) N-benzyl-2-carboxy mPEG2 amino-3-methoxy propionamide: 1H NMR (500 MHz, CDCl3) δ 3.38 (s, 3H), 3.39 (s, 3H), 3.50 (m, 1H), 3.56 (m, 2H), 3.64 (m, 2H), 3.70 (t, 2H), 3.89 (m, 1H), 4.25 (m, 2H), 4.34 (br., 1H).", "4.50 (m, 2H), 5.71 (br., 1H), 6.74 (br., 1H), 7.28 (m, 3H), 7.36 (m, 2H).", "LC-MS (m/z) calculated 354.2; found, 355.2 [M+H]+, 378.1 [M+Na]+.", "(2R) N-benzyl-2-carboxy mPEG3 amino-3-methoxy propionamide: 1H NMR (500 MHz, CDCl3) δ 3.38 (s, 6H), 3.50 (m, 1H), 3.56 (m, 2H), 3.64 (m, 6H), 3.70 (t, 2H), 3.89 (m, 1H), 4.25 (m, 2H), 4.34 (br., 1H).", "4.50 (m, 2H), 5.71 (br., 1H), 6.77 (br., 1H), 7.27 (m, 3H), 7.36 (m, 2H).", "LC-MS (m/z) calculated 398.2; found, 399.2 [M+H]+, 421.1 [M+Na]+.", "(2R) N-benzyl-2-carboxy mPEG4 amino-3-methoxy propionamide: 1H NMR (500 MHz, CDCl3) δ 3.38 (s, 6H), 3.51 (m, 1H), 3.56 (m, 2H), 3.64 (m, 10H), 3.70 (t, 2H), 3.89 (m, 1H), 4.25 (m, 2H), 4.34 (br., 1H).", "4.50 (m, 2H), 5.71 (br., 1H), 6.78 (br., 1H), 7.27 (m, 3H), 7.34 (m, 2H).", "LC-MS (m/z) calculated 442.2; found, 443.2 [M+H]+, 465.2 [M+Na]+.", "(2R) N-benzyl-2-carboxy mPEG5 amino-3-methoxy propionamide: 1H NMR (500 MHz, CDCl3) δ 3.36 (s, 3H), 3.38 (s, 3H), 3.51 (m, 1H), 3.56 (m, 2H), 3.64 (m, 14H), 3.70 (t, 2H), 3.89 (m, 1H), 4.25 (m, 2H), 4.34 (br., 1H).", "4.50 (m, 2H), 5.75 (br., 1H), 6.82 (br., 1H), 7.27 (m, 3H), 7.35 (m, 2H).", "LC-MS (m/z) calculated 486.2; found, 487.2 [M+H]+, 509.2 [M+Na]+.", "(2R) N-benzyl-2-carboxy mPEG6 amino-3-methoxy propionamide: 1H NMR (500 MHz, CDCl3) δ 3.38 (s, 3H), 3.39 (s, 3H), 3.51 (m, 1H), 3.56 (m, 2H), 3.65 (m, 18H), 3.70 (t, 2H), 3.89 (m, 1H), 4.25 (m, 2H), 4.34 (br., 1H).", "4.50 (m, 2H), 5.75 (br., 1H), 6.80 (br., 1H), 7.27 (m, 3H), 7.34 (m, 2H).", "LC-MS (m/z) calculated 530.3; found, 531.2 [M+H]+, 553.2 [M+Na]+.", "(2R) N-benzyl-2-carboxy mPEG7 amino-3-methoxy propionamide: 1H NMR (500 MHz, CDCl3) δ 3.38 (s, 3H), 3.39 (s, 3H), 3.50 (m, 1H), 3.56 (m, 2H), 3.65 (m, 22H), 3.70 (t, 2H), 3.89 (m, 1H), 4.25 (m, 2H), 4.34 (br., 1H).", "4.50 (m, 2H), 5.75 (br., 1H), 6.82 (br., 1H), 7.27 (m, 3H), 7.34 (m, 2H).", "LC-MS (m/z) calculated 574.3; found, 575.2 [M+H]+, 597.2 [M+Na]+.", "(2R) N-benzyl-2-carboxy mPEG8 amino-3-methoxy propionamide: 1H NMR (500 MHz, CDCl3) δ 3.37 (s, 3H), 3.39 (s, 3H), 3.51 (m, 1H), 3.56 (m, 2H), 3.65 (m, 28H), 3.82 (m, 1H), 4.20 (m, 2H), 4.42 (br., 1H).", "4.45 (m, 2H), 5.80 (br., 1H), 6.90 (br., 1H), 7.23 (m, 3H), 7.31 (m, 2H).", "LC-MS (m/z) calculated 618.3; found, 619.3 [M+H]+, 636.2 [M+NH4]+.", "(2R) N-benzyl-2-carboxy mPEG9 amino-3-methoxy propionamide: 1H NMR (500 MHz, CDCl3) δ 3.38 (s, 3H), 3.39 (s, 3H), 3.51 (m, 1H), 3.56 (m, 2H), 3.65 (m, 32H), 3.80 (m, 1H), 4.25 (m, 2H), 4.35 (br., 1H).", "4.50 (m, 2H), 5.75 (br., 1H), 6.80 (br., 1H), 7.27 (m, 3H), 7.34 (m, 2H).", "LC-MS (m/z) calculated 662.4; found, 663.3 [M+H]+, 680.4 [M+NH4]+.", "Example 2 Na+ Channel Blocking Examination Lacosamide, (R)—N-benzyl-2-acetamido-3-methoxy propionamide, is believed to owe at least part of its pharmacologic activity to the inhibition of voltage-gated sodium channels by selectively interacting with the slow-inactivated confirmation of the channel.", "Using an automated whole-cell patch-clamp approach, the in vitro effects of oligomer-containing compounds of the invention (synthesis described in Example 1) on cloned hNav1.8 channels expressed in CHO cells relative to control (lacosamide) were evaluated.", "The procedures used in this experiment followed those set forth in Sheets et al.", "(2008) J Pharmacol Exp Ther 326(1):89-99.Briefly, automated patch clamp electrophysiological procedures were carried out in the IonWorks Quattro™ system (Molecular Devices Corporation, Union City Calif.).", "In preparation for a current recording session, intracellular solution (140 mM KCl, 5 mM MgCl2, 0.5 mM EGTA, 10 mM HEPES, 0.1 mg/mL amphotericin B) was loaded into the intracellular compartment of the Population Patch Clamp™ (PPC) planar electrode.", "CHO cells stably expressing the human Nav1.8 sodium channel subtype were suspended in HEPES-buffered physiological saline solution (137 mM NaCl, 4 mM KCl, 1.8 mM CaCl2, 1 mM MgCl2, 10 mM HEPES, 10 mM Glucose, pH adjusted to 7.4 with NaOH) and pipetted into the wells of the PPC planar electrode.", "After establishment of a whole-cell configuration (the perforated patch), membrane currents were recorded using patch clamp amplifier in the IonWorks Quattro™ system.", "Test article concentrations, loaded in a 384-well compound plate, were applied to naïve cells (one concentration per cell) via steel needles of a 48-channel pipettor.", "Each application consisted of addition of 6 μL of 2× concentrated test article solution to the total 12 μL final volume of the extracellular well of the PPC planar electrode.", "The PPC well contents were then mixed (three times) following addition of test article.", "All experiments were performed at ambient temperature.", "Block of hNav1.8 sodium channel was measured using a stimulus voltage pattern shown in FIG.", "1, and voltage potentials are indicated in Table 1.The pulse pattern was repeated twice (once before addition of test article and the other five minutes after test article addition).", "Peak current amplitudes were measured at three test pulses: TP1 (tonic block), TP11 (frequency-dependent block at 10 Hz), and TP12 (inactivated state block).", "TABLE 1 Voltage-protocol parameters for hNav1.8 channels Test Pulse Test Holding Pre-Pulse 1-10, 12-14 Pulse 11 Interpulse Test Pulse 1-14 Potential Potential Duration Duration Duration Potential Channel (mV) (mV) (ms) (ms) (ms) (mV) Nav1.8 −80 −120 20 500 80 20 Data acquisition and analyses were performed using the IonWorks Quattro™ system operation software (version 2.0.2; Molecular Devices Corporation, Union City, Calif.).", "Inhibition potencies were estimated from concentration-response curves fitted using the Hill function: % Block=% VC+{(100−% VC)−(100−% VC)/[1+([Test]/IC50)N]}, where [Test] is the concentration of test article, IC50 is the concentration of the test article producing half-maximal inhibition, N is the Hill coefficient, % VC is the percentage of the current run-down (the mean current inhibition at the vehicle control) and % Block is the percentage of ion channel current inhibited at each concentration of the test article.", "As shown in Table 2, the (2R) N-benzyl-2-carboxy mPEG1 amino-3-methoxy propionamide, (2R) N-benzyl-2-carboxy mPEG2 amino-3-methoxy propionamide, and (2R) N-benzyl-2-carboxy mPEG3 amino-3-methoxy propionamide all blocked hNav1.8 channels in the inactivated state with a potency comparable to control (i.e., lacosamide).", "TABLE 2 Results of Na+ Channel Blocking Examination Type of block IC50 (μM) Inactivated Test compound Tonic 10 Hz state (R)-N-benzyl-2-acetamido-3-methoxy propionamide (lacosamide) >300 >300 278 (2R) N-benzyl-2-carboxy mPEG1 amino-3-methoxy propionamide >300 >300 267 (2R) N-benzyl-2-carboxy mPEG2 amino-3-methoxy propionamide >300 >300 166 (2R) N-benzyl-2-carboxy mPEG3 amino-3-methoxy propionamide >300 >300 239 (2R) N-benzyl-2-carboxy mPEG4 amino-3-methoxy propionamide >300 >300 >300 (2R) N-benzyl-2-carboxy mPEG5 amino-3-methoxy propionamide >300 >300 >300 (2R) N-benzyl-2-carboxy mPEG6 amino-3-methoxy propionamide >300 >300 >300 (2R) N-benzyl-2-carboxy mPEG7 amino-3-methoxy propionamide >300 >300 >300 (2R) N-benzyl-2-carboxy mPEG8 amino-3-methoxy propionamide >300 >300 >300 (2R) N-benzyl-2-carboxy mPEG9 amino-3-methoxy propionamide >300 >300 >300 Example 3 Pain Model—Formalin-Induced Paw Licking in the Mouse Lacosamide has been proposed for reduction of pain and a pain model based on formalin-induced paw licking was used to evaluate the ability of oligomer-containing compounds to reduce pain.", "In the formalin-induced paw licking model, a test compound is administered via oral gavage (“PO”) followed in thirty minutes by the subcutaneous injection of formalin to a hind paw of a mouse.", "Subcutaneous injection of formalin first causes a pain-inducing mechanical injury (involving bradykinin and substance P) in the first five minutes (“Phase 1”) followed by a pain-inducing inflammatory response (involving bradykinin, histamine, serotonin and prostaglandins) occurring between 15-30 minutes (“Phase 2”) following the formalin injection.", "Both pain-inducing stimuli causes a characteristic “paw licking” response.", "The amount of time spent licking the formalin-injected paw is measured during Phase 1 and Phase 2.If the test article has relatively good pain reducing properties, a reduction in the time spent licking the formalin-injected paw is observed compared to the saline control group.", "In contrast, if the test article has relatively poor pain reducing properties, the duration of the “paw licking” response will be comparable to the saline control group.", "By measuring a series of test articles, it is possible to understand each test article's pain reducing activity relative to each other.", "Table 3 lists the test articles administered to the mouse (each test article diluted in 0.5% CMC (carboxymethylcellulose) and all test articles except lacosamide and (2R) N-benzyl-2-carboxy mPEG1 amino-3-methoxy propionamide were soluble in this vehicle.", "For the test articles that were not readily soluble, test articles were sonicated and vortexed until a uniform suspension was achieved.", "TABLE 3 Test Articles Administered in Formalin-Induced Paw Licking Model Test Article Dose Route Saline — PO (R)-N-benzyl-2-acetamido-3-methoxy propionamide (lacosamide) 200 PO (2R) N-benzyl-2-carboxy mPEG1 amino-3-methoxy propionamide 200 PO (2R) N-benzyl-2-carboxy mPEG2 amino-3-methoxy propionamide 200 PO (2R) N-benzyl-2-carboxy mPEG3 amino-3-methoxy propionamide 200 PO (2R) N-benzyl-2-carboxy mPEG4 amino-3-methoxy propionamide 200 PO (2R) N-benzyl-2-carboxy mPEG5 amino-3-methoxy propionamide 200 PO (2R) N-benzyl-2-carboxy mPEG6 amino-3-methoxy propionamide 200 PO (2R) N-benzyl-2-carboxy mPEG7 amino-3-methoxy propionamide 200 PO (2R) N-benzyl-2-carboxy mPEG8 amino-3-methoxy propionamide 200 PO (2R) N-benzyl-2-carboxy mPEG9 amino-3-methoxy propionamide 200 PO During the experiment, side effects such as sedation and splayed posture were observed in animals orally dosed with 200 mg/kg lacosamide (Phase 1: 5/7 mice sedated and 5/7 mice with splayed posture, and Phase 2: 6/7 mice sedated and 7/7 splayed posture) and not with any of the oligomer-containing compounds.", "Furthermore, each of (2R) N-benzyl-2-carboxy mPEG2 amino-3-methoxy propionamide, (2R) N-benzyl-2-carboxy mPEG3 amino-3-methoxy propionamide, (2R) N-benzyl-2-carboxy mPEG4 amino-3-methoxy propionamide, and (2R) N-benzyl-2-carboxy mPEG5 amino-3-methoxy propionamide showed a reduction in formalin-induced paw licking compared to saline in Phase 2.Lacosamide showed the greatest reduction in formalin-induced paw licking time in both Phase 1 and Phase 2.However, this may be attributed to the side effects observed in both phases.", "Overall, a reduction in pain response was seen with some of the PEGylated conjugates without the side effects that were observed with lacosamide.", "Example 4 Formalin Model of Persistent Pain in the Rat Using the same principles of Example 3, an automated system for measuring responses in rats following formalin injection was used to further test the ability of test articles to reduce pain induced by formalin.", "Following subcutaneous injection of formalin into the hind paw of a rat, flinching behavior (number of events) was measured for sixty minutes post formalin injection using an automated nociception analyzer (ANA Instrument, University of California, San Diego).", "Automated systems have been validated.", "See, for example, Yaksh et al.", "(2001) J. Appl.", "Physiol.", "90:2386-2402.Briefly, similar to Example 3, a test compound is administered via oral gavage (“PO”) or intraperitoneally 30-60 minutes prior to the subcutaneous injection of formalin to a hind paw of a rat.", "As with Example 3, “Phase 1” and “Phase 2” responses are detectable.", "Rather than being measured manually, responses are collected via a system specifically designed to measure the characteristic behavior associated with formalin-induced pain.", "For each of saline, morphine, (2R) N-benzyl-2-carboxy mPEG1 amino-3-methoxy propionamide, (2R) N-benzyl-2-carboxy mPEG3 amino-3-methoxy propionamide, (2R) N-benzyl-2-carboxy mPEG5 amino-3-methoxy propionamide, (2R) N-benzyl-2-carboxy mPEG7 amino-3-methoxy propionamide, FIG.", "2 lists the cumulative number of flinches for each of Phase 1 and Phase 2.In this model, tested oligomer-containing articles at a single dose of 100 mg/kg intraperitoneally did not significantly suppress the Phase I or Phase II behaviors induced by formalin." ] ]
Patent_15875864
[ [ "MINIATURE DEVICE HAVING AN ACOUSTIC DIAPHRAGM", "A method of forming a device having a compliant member includes creating a membrane having one or more elastomeric layers which are at least partially cured.", "Another elastomeric layer is provided on the membrane in an uncured state.", "At least one of a bobbin and a housing are positioned so that an end of the bobbin or housing, or the ends of both the bobbin and housing, extend at least partially into the uncured elastomeric layer.", "The uncured elastomeric layer is then cured to secure it to the membrane and to the housing or bobbin, or both the housing and bobbin.", "The method substantially reduces or eliminates the formation of holes that can form during fabrication or use of the device." ], [ "1.A microspeaker device comprising: an acoustic diaphragm having a substantially planar shape, the acoustic diaphragm comprising: a first layer of an elastomeric material; and a second layer of an elastomeric material disposed on the first layer; a housing having an end extending at least partially into the second layer, wherein the second layer adheres to the first layer and to a portion of the housing at the end of the housing; a bobbin having a surface and disposed in the housing, the bobbin having an end extending at least partially into the second layer, wherein the second layer adheres to a portion of the bobbin at the end of the bobbin; and a coil wound on the surface of the bobbin.", "2.The microspeaker device of claim 1 wherein the acoustic diaphragm further comprises at least one intermediate layer disposed between the first layer and the second layer.", "3.The microspeaker device of claim 2 wherein the at least one intermediate layer is formed of a viscous elastomeric material.", "4.The microspeaker device of claim 3 wherein the at least one intermediate layer comprises a layer formed of an elastomeric material that is more viscous than the elastomeric material of the first layer and the elastomeric material of the second layer.", "5.The microspeaker device of claim 1 wherein the first layer has a thickness that is greater than a thickness of the second layer.", "6.The microspeaker device of claim 1 wherein at least one of the first and second layers is a silicone layer.", "7.The microspeaker device of claim 6 wherein the silicone layer is formed of a room temperature vulcanization silicone.", "8.The microspeaker device of claim 1 wherein an area of the acoustic diaphragm defined within a diameter of the bobbin is stiffer than a surrounding annular area of the acoustic diaphragm.", "9.The microspeaker device of claim 1 wherein the housing is a tube having an opening at the end.", "10.The microspeaker device of claim 1 wherein the elastomeric material of the first layer is different from the elastomeric material of the second layer.", "11.The microspeaker device of claim 1 wherein the second layer includes a meniscus formed at a surface of the bobbin or the housing.", "12.The microspeaker device of claim 1 wherein the end of the housing is in contact with a surface of the first layer.", "13.The microspeaker device of claim 1 wherein the end of the bobbin is in contact with a surface of the first layer." ], [ "<SOH> BACKGROUND <EOH>This disclosure relates to a miniature device having a compliant member.", "More particularly, the disclosure relates to a method of fabricating an acoustic diaphragm on the miniature device." ], [ "<SOH> SUMMARY <EOH>In one aspect, a microspeaker device includes an acoustic diaphragm, a housing, a bobbin and a coil.", "The acoustic diaphragm has a substantially planar shape and includes a first layer of an elastomeric material and a second layer of an elastomeric material disposed on the first layer of elastomeric material.", "The housing has an end extending at least partially into the second layer, wherein the second layer adheres to the first layer and to a portion of the housing at the end of the housing.", "The bobbin has a surface and is disposed in the housing.", "The bobbin has an end extending at least partially into the second layer, wherein the second layer adheres to a portion of the bobbin at the end of the bobbin.", "The coil is wound on the surface of the bobbin.", "Examples may include one or more of the following: The acoustic diaphragm may further include at least one intermediate layer disposed between the first layer and the second layer.", "The at least one intermediate layer may be formed of a viscous elastomeric material.", "The at least one intermediate layer may include a layer formed of an elastomeric material that is more viscous than the elastomeric material of the first layer and the elastomeric material of the second layer.", "The first layer may have a thickness that is greater than a thickness of the second layer.", "At least one of the first and second layers may be a silicone layer.", "The silicone layer may be formed of a room temperature vulcanization silicone.", "An area of the acoustic diaphragm defined within a diameter of the bobbin may be stiffer than a surrounding annular area of the acoustic diaphragm.", "The housing may be a tube having an opening at the end.", "The elastomeric material of the first layer may be different from the elastomeric material of the second layer.", "The second layer may include a meniscus formed at a surface of the bobbin or the housing.", "The end of the housing may be in contact with a surface of the first layer and the end of the bobbin may be in contact with a surface of the first layer." ], [ "RELATED APPLICATIONS This application is a divisional application of U.S. application Ser.", "No.", "15/182,069, filed Jun.", "14, 2016 and titled “Miniature Device Having an Acoustic Diaphragm,” the entirety of which application is incorporated by reference herein.", "BACKGROUND This disclosure relates to a miniature device having a compliant member.", "More particularly, the disclosure relates to a method of fabricating an acoustic diaphragm on the miniature device.", "SUMMARY In one aspect, a microspeaker device includes an acoustic diaphragm, a housing, a bobbin and a coil.", "The acoustic diaphragm has a substantially planar shape and includes a first layer of an elastomeric material and a second layer of an elastomeric material disposed on the first layer of elastomeric material.", "The housing has an end extending at least partially into the second layer, wherein the second layer adheres to the first layer and to a portion of the housing at the end of the housing.", "The bobbin has a surface and is disposed in the housing.", "The bobbin has an end extending at least partially into the second layer, wherein the second layer adheres to a portion of the bobbin at the end of the bobbin.", "The coil is wound on the surface of the bobbin.", "Examples may include one or more of the following: The acoustic diaphragm may further include at least one intermediate layer disposed between the first layer and the second layer.", "The at least one intermediate layer may be formed of a viscous elastomeric material.", "The at least one intermediate layer may include a layer formed of an elastomeric material that is more viscous than the elastomeric material of the first layer and the elastomeric material of the second layer.", "The first layer may have a thickness that is greater than a thickness of the second layer.", "At least one of the first and second layers may be a silicone layer.", "The silicone layer may be formed of a room temperature vulcanization silicone.", "An area of the acoustic diaphragm defined within a diameter of the bobbin may be stiffer than a surrounding annular area of the acoustic diaphragm.", "The housing may be a tube having an opening at the end.", "The elastomeric material of the first layer may be different from the elastomeric material of the second layer.", "The second layer may include a meniscus formed at a surface of the bobbin or the housing.", "The end of the housing may be in contact with a surface of the first layer and the end of the bobbin may be in contact with a surface of the first layer.", "BRIEF DESCRIPTION OF THE DRAWINGS The above and further advantages of examples of the present inventive concepts may be better understood by referring to the following description in conjunction with the accompanying drawings, in which like numerals indicate like structural elements and features in various figures.", "The drawings are not necessarily to scale, emphasis instead being placed upon illustrating the principles of features and implementations.", "FIG.", "1A, FIG.", "1B and FIG.", "1C are a perspective illustration, a perspective cutaway illustration and an exploded cutaway illustration, respectively, of an example of a microspeaker for a miniature earbud.", "FIG.", "2 is a flowchart representation of a method of forming a device having a compliant member.", "FIGS.", "3A to 3E are cross-sectional illustrations showing sequentially how the method of FIG.", "2 is applied to fabricate a microspeaker device.", "FIG.", "4 is a magnified view of a portion of the end of the microspeaker device of FIG.", "3D.", "FIG.", "5 shows a magnified cross-sectional view of a portion of an alternative microspeaker device.", "FIG.", "6 shows an example of a microspeaker in which the intermediate layer of the microspeaker of FIG.", "5 is formed as three individual layers.", "DETAILED DESCRIPTION Modern in-ear headphones, or earbuds, typically include microspeakers.", "The microspeaker may include a coil that is attached to an acoustic diaphragm either directly or through a bobbin on which the coil is wound.", "Motion of the diaphragm due to an electrical signal provided to the coil results in generation of an acoustic signal that is responsive to the electrical signal.", "The microspeaker typically includes a housing, such as a sleeve or tube, which encloses the bobbin, coil and a magnetic structure.", "As the size of the earbud decreases, it becomes increasingly difficult to fabricate the acoustic diaphragm with an elastic suspension at one end of the bobbin (or coil) and housing.", "FIG.", "1A, FIG.", "1B and FIG.", "1C are a perspective illustration, a perspective cutaway illustration and an exploded cutaway illustration, respectively, of an example of a microspeaker 10 that can be used in a miniature earbud.", "The microspeaker 10 includes a cylindrical housing 12 having an opening at both ends.", "Inside the housing 12 is a bobbin 14 that is nominally cylindrical in shape and which is open at least at one end.", "The housing 12 and bobbin 14 are secured at one of their ends to a compliant member 16.In some examples, the housing 12 is made of stainless steel and the bobbin 14 is made of a polyimide (e.g., KAPTON®) or polyethylene terephthalate (PET) (e.g., MYLAR®).", "A magnet assembly 18 is secured to a platform 19 at an end of the housing that is opposite to the compliant member 16.The magnet assembly 18 includes two magnet pieces 18A and 18B separated by a coin 18C.", "The magnet assembly 18 extends along an axis 20 of the housing 12 and into an open region inside the bobbin 14.In one example, the magnet pieces 18A and 18B are cylindrical neodymium magnets.", "A coil 22 is wound onto an outside surface of the bobbin 14.The bobbin 14 moves substantially along the housing axis 20 in response to an electrical current conducted through the coil 22.In turn, a central circular portion of the compliant member 16 moves axially and displaces air to thereby create an acoustic signal.", "One technique for fabricating the compliant member 16 includes placing an open end of the housing 12 and an open end of the bobbin 14 into a single thin layer of liquid silicone.", "The liquid silicone is then cured to form the compliant member 16.The central region of the compliant member 16 that is located within the end region of the bobbin can be stiffened while the annular region that surrounds the central region remains compliant.", "Difficulties arise with this technique as the liquid silicone has a surface tension that causes the liquid to adhere to and “climb up” the walls of the housing 12 and the bobbin 14 to form a meniscus.", "The result is a reduction of the thickness of the cured layer of silicone which can lead to holes in the compliant member 16.Holes can form during the demolding process because the compliant member 16 is weak at thin areas.", "Thinned areas may result in holes or tearing being generated during operation of the microspeaker.", "FIG.", "2 is a flowchart representation of an example of a method 100 of forming a device having a compliant member.", "Reference is also made to FIGS.", "3A to 3E which are cross-sectional side view illustrations showing, in a sequential manner, the method 100 as applied to fabrication of a microspeaker device 20 in which the compliant member 16 can subsequently be processed to form an acoustic diaphragm and a surround.", "According to the method 100, a membrane is created (110) having one or more elastomeric layers which are at least partially cured.", "As used herein, the term “partially cured” means that a skin coat is formed on top of an elastomeric layer to a degree that the elastomeric material in that layer will not flow or mix with a new layer of liquid elastomeric material deposited on the partially cured layer.", "As an alternative, the degree of cure can be controlled so that there is some mixing that occurs at the interface of two layers.", "As shown in FIG.", "3A, the membrane can be formed by depositing a layer 22 of a liquid elastomeric material such as liquid silicone on a surface of a substrate 24.The viscosity of the silicone generally is sufficient such that the thickness of the applied layer does not significantly change although surface features and bumps typically disappear over time until the surface is substantially flat.", "The liquid elastomeric material is then partially or fully cured.", "In one example, the silicone is cured using a platinum catalyst in a 150° C. environment for approximately 45 minutes.", "Although not shown, this step may be repeated to form a multi-layer membrane by depositing one or more additional layers of a liquid elastomeric material and then partially or fully curing each of these layers before applying an additional layer.", "These subsequent layers may be similarly cured at 150° C. but for longer times (e.g., several hours or more).", "In alternative methods, an ultraviolet (UV) cure may be used or a room temperature vulcanization (RTV) silicone may be used.", "The method 100 continues by providing (120) an uncured additional elastomeric layer 26 on the layer 22 as shown in FIG.", "3B.", "Referring to FIG.", "3C, a housing 28 (only an end portion is shown) is positioned (130) such that the end of the housing 28 extends at least partially into the uncured elastomeric layer 26.In some instances, the housing 28 may be positioned so that its end is in contact with the upper surface 29 of the layer 22 of the partially or fully cured elastomeric material.", "A structure 30, such as a bobbin, (only an end portion is shown) is positioned inside the housing 28 so that the end of the structure 30 extends at least partially into the uncured elastomeric layer 26.Subsequently, the uncured elastomeric layer 26 is cured (140) so that the layer 26 is secured to the ends of the housing 28 and the bobbin 30, and adheres to the membrane 22.In one example, the housing 28 is in the form of a cylindrical tube and the bobbin 30 is configured to move in a direction along the tube axis.", "After the final layer 26 is cured, the microspeaker device may be removed from the substrate 24 as shown in FIG.", "3D.", "The removal may include a demolding process in which the compliant member (defined by the combination of layers 22 and 26) is progressively released from the substrate 24, starting from the outside diameter of the device and progressing toward the center.", "The portion of the compliant member 22 and 26 that extends beyond the outer diameter of the housing 28 can be trimmed or removed by other means to limit the diameter to be approximately equal to the outer diameter of the housing 28 as shown in FIG.", "3E.", "When at rest, the compliant member formed according to the method 100 has a substantially planar shape.", "The bobbin 30 and a coil (not shown) wound on the outer surface of the bobbin 30 are fully supported by the compliant member, that is, the bobbin 30 is not in contact with any other structure.", "As described above, the central region of the compliant member, i.e., the area defined within the diameter of the bobbin 30, can be stiffened to form the acoustic diaphragm while the surrounding annular area defines a compliant surround that enables the acoustic diaphragm to moves axially and thereby generate an acoustic signal.", "In some examples, the liquid elastomeric material used to form the layers 22 and 26 is liquid silicone.", "Alternatively, one layer 22 can be formed from an elastomeric material that is different from the elastomeric material of the other layer 26 that is used to secure the housing 28 and bobbin 30.In such implementations, the materials are selected for chemical compatibility to ensure good adherence between the layers 22 and 26.In the following example, the thickness of the layer 22 is greater than the thickness of the layer 26; however, in other implementations the thickness of the layer 22 may be the same as or less than that of the layer 26.By way of a specific non-limiting numerical example, the thickness of the layer 22 may be 30 μm and the thickness of the additional layer 26 may be 20 μm.", "Referring to FIG.", "4 which shows a magnified view of the end of the housing 28 and the bobbin 30, the depth of the additional layer 26 before curing may be chosen to achieve a liquid meniscus 36 formed at the end of the housing 28 and another liquid meniscus 38 formed at the end of the bobbin 30 of desired sizes.", "Using a smaller thickness for the additional layer 26 can limit the extent of the menisci 36 and 38 along the housing 28 and bobbin 30.In addition, thinning of the additional layer 26 is less critical when the thickness of the underlying layer 22 is substantially greater than the thickness of the additional layer 26.The extent of the menisci 36 and 38 along the housing 28 and the bobbin 30 should be sufficient to enable support of the bobbin 30 and coil while affording proper adhesion to the underlying layer 22.In some instances the bobbin suspended from the compliant member may exhibit undesirable motion, such as rocking or other non-axial motion.", "To address this situation, the compliant member may be formed to provide damping, or dissipation, into the suspension.", "For example, the compliant member may be formed of three layers as shown in FIG.", "5.Specifically, two elastomeric silicone layers 40 and 42 may be formed with a low creep silicone and an intermediate layer 44 formed with a more viscous silicone gel.", "By way of a specific non-limiting example, the upper and lower layers 42 and 40 may be formed from a low creep silicone elastomer such as ELASTOSIL® 3070/OO-20 SM and the intermediate layer 44 may be formed with POWERSIL® silicone gel available from Wacker Chemie AG of Munich, Germany.", "Although the surround portion which is outside of the outer diameter of the bobbin 30 has increased loss in comparison to a compliant member without the viscous intermediate layer 44, this compliant member has the advantage of limiting the height of a resonance peak and reducing unwanted rocking or sideways motion.", "FIG.", "6 shows an alternative example in which the intermediate layer 44 is formed as three individual layers 44A, 44B and 44C.", "It should be recognized that any number of layers can be used to “build” the intermediate layer 44.A greater number of layers may be preferred when using lower viscosity elastomeric materials in an uncured state.", "The examples described above provide advantages over a compliant member formed from a single layer of an elastomeric material.", "The boundary at the interface of the compliant member and the housing and/or other structure is better controlled.", "Generally there is less filleting and thinning of the member near the interface regions.", "Reduced thinning results in a stronger device that is easier to demold from the flat substrate without tearing the compliant member.", "Moreover, the stiffness of the suspension provided by the complaint member is more consistently achieved during manufacturing processes in comparison to a single layer compliant member.", "A number of implementations have been described.", "Nevertheless, it will be understood that the foregoing description is intended to illustrate, and not to limit, the scope of the inventive concepts which are defined by the scope of the claims.", "Other examples are within the scope of the following claims." ] ]
Patent_15875866
[ [ "POWER TRANSMISSION SYSTEM OF VEHICLE", "A power transmission system of a vehicle may include a first input shaft selectively connected to an engine, a second input shaft as a hollow shaft, enclosing the first input shaft without rotational interference with the first input shaft, and selectively connected to the engine, a speed change portion including first and second planetary gear sets, each planetary gear set including three rotation elements, and four rotation shafts directly connected to at least one rotation element among the rotation elements of the first and second planetary gear sets, a motor/generator, an output shaft, and control elements including two clutches disposed at positions where the first and second input shafts are selectively connected to an output shaft of the engine, and two brakes disposed at positions where two rotation shafts among the four rotation shafts are selectively connected to a transmission housing." ], [ "1.A power transmission system of a vehicle comprising: a first input shaft selectively connected to an engine; a second input shaft as a hollow shaft, enclosing the first input shaft without rotational interference with the first input shaft, and selectively connected to the engine; an output shaft outputting torque; a first planetary gear set including first, second, and third rotation elements; a second planetary gear set including fourth, fifth, and sixth rotation elements; a first rotation shaft fixedly connected to the first rotation element; a second rotation shaft fixedly connected to the second rotation element and fixedly connected to the sixth rotation element; a third rotation shaft fixedly connected to the third rotation element, fixedly connected to the fifth rotation element, and fixedly connected to the output shaft; a fourth rotation shaft fixedly connected to the fourth rotation element; and a first motor/generator fixedly connected to the first rotation shaft or the second rotation shaft.", "2.The power transmission system of claim 1, wherein the first planetary gear set is a single pinion planetary gear set, wherein a first sun gear is the first rotation element, a first planet carrier is the second rotation element, and a first ring gear is the third rotation element, and the second planetary gear set is a single pinion planetary gear set, wherein a second sun gear is the fourth rotation element, a second planet carrier is the fifth rotation element, and a second ring gear is the sixth rotation element.", "3.The power transmission system of claim 2, wherein the fourth rotation shaft is fixedly connected to the second input shaft, the second rotation shaft is fixedly connected to the first input shaft and is selectively connected to a transmission housing, and the first rotation shaft is selectively connected to the transmission housing and is fixedly connected to the first motor/generator.", "4.The power transmission system of claim 3, further comprising: a first clutch disposed between an engine output shaft and the second input shaft; a second clutch disposed between the engine output shaft and the first input shaft; a first brake disposed between the first rotation shaft and the transmission housing; and a second brake disposed between the second rotation shaft and the transmission housing.", "5.The power transmission system of claim 3, further comprising a second motor/generator fixedly connected to the fourth rotation shaft.", "6.The power transmission system of claim 2, wherein the fourth rotation shaft is fixedly connected to the second input shaft, the second rotation shaft is fixedly connected to the first input shaft, is selectively connected to a transmission housing, and is fixedly connected to the first motor/generator, and the first rotation shaft is selectively connected to the transmission housing.", "7.The power transmission system of claim 6, further comprising: a first clutch disposed between an engine output shaft and the second input shaft; a second clutch disposed between the engine output shaft and the first input shaft; a first brake disposed between the first rotation shaft and the transmission housing; and a second brake disposed between the second rotation shaft and the transmission housing.", "8.The power transmission system of claim 6, further comprising a second motor/generator fixedly connected to the first rotation shaft.", "9.A power transmission system of a vehicle comprising: an engine output shaft transmitting torque of an engine; an output shaft outputting torque; a first planetary gear set including first, second, and third rotation elements; a second planetary gear set including fourth, fifth, and sixth rotation elements; a first rotation shaft fixedly connected to the first rotation element, fixedly connected to a first motor/generator, and selectively connected to a transmission housing; a second rotation shaft fixedly connected to the second rotation element, fixedly connected to the sixth rotation element, selectively connected to the transmission housing, and selectively connected to the engine output shaft; a third rotation shaft fixedly connected to the third rotation element, fixedly connected to the fifth rotation element, and fixedly connected to the output shaft; and a fourth rotation shaft fixedly connected to the fourth rotation shaft and selectively connected to the engine output shaft.", "10.The power transmission system of claim 9, wherein the first planetary gear set is a single pinion planetary gear set, wherein a first sun gear is the first rotation element, a first planet carrier is the second rotation element, and a first ring gear is the third rotation element, and the second planetary gear set is a single pinion planetary gear set, wherein a second sun gear is the fourth rotation element, a second planet carrier is the fifth rotation element, and a second ring gear is the sixth rotation element.", "11.The power transmission system of claim 9, further comprising: a first clutch selectively connecting the engine output shaft to the fourth rotation shaft; a second clutch selectively connecting the engine output shaft to the second rotation shaft; a first brake selectively connecting the first rotation shaft to the transmission housing; and a second brake selectively connecting the second rotation shaft to the transmission housing.", "12.The power transmission system of claim 9, further comprising a second motor/generator fixedly connected to the fourth rotation shaft.", "13.A power transmission system of a vehicle comprising: an engine output shaft transmitting torque of an engine; an output shaft outputting torque; a first planetary gear set including first, second, and third rotation elements; a second planetary gear set including fourth, fifth, and sixth rotation elements; a first rotation shaft fixedly connected to the first rotation element and selectively connected to a transmission housing; a second rotation shaft fixedly connected to the second rotation element, fixedly connected to the sixth rotation element, selectively connected to the transmission housing, selectively connected to the engine output shaft, and fixedly connected to a first motor/generator; a third rotation shaft fixedly connected to the third rotation element, fixedly connected to the fifth rotation element, and fixedly connected to the output shaft; and a fourth rotation shaft fixedly connected to the fourth rotation shaft and selectively connected to the engine output shaft.", "14.The power transmission system of claim 13, wherein the first planetary gear set is a single pinion planetary gear set, wherein a first sun gear is the first rotation element, a first planet carrier is the second rotation element, and a first ring gear is the third rotation element, and the second planetary gear set is a single pinion planetary gear set, wherein a second sun gear is the fourth rotation element, a second planet carrier is the fifth rotation element, and a second ring gear is the sixth rotation element.", "15.The power transmission system of claim 13, further comprising: a first clutch selectively connecting the engine output shaft to the fourth rotation shaft; a second clutch selectively connecting the engine output shaft to the second rotation shaft; a first brake selectively connecting the first rotation shaft to the transmission housing; and a second brake selectively connecting the second rotation shaft to the transmission housing.", "16.The power transmission system of claim 13, further comprising a second motor/generator fixedly connected to the first rotation shaft." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> BRIEF SUMMARY <EOH>Various aspects of the present invention are directed to providing a power transmission system of a vehicle having advantages of enhancing power delivery efficiency by achieving at least four fixed speed stages and enabling continuous changing of a gear ratio using a motor.", "According to various aspects of the present invention, a power transmission system of a vehicle may include an output shaft outputting torque, a first planetary gear set including first, second, and third rotation elements, a second planetary gear set including fourth, fifth, and sixth rotation elements, a first rotation shaft fixedly connected to the first rotation element, a second rotation shaft fixedly connected to the second rotation element and fixedly connected to the sixth rotation element, a third rotation shaft fixedly connected to the third rotation element, fixedly connected to the fifth rotation element, and fixedly connected to the output shaft, a fourth rotation shaft fixedly connected to the fourth rotation element, and a first motor/generator fixedly connected to the first rotation shaft or the second rotation shaft.", "The first planetary gear set may be a single pinion planetary gear set, wherein a first sun gear is the first rotation element, a first planet carrier is the second rotation element, and a first ring gear is the third rotation element, and the second planetary gear set may be a single pinion planetary gear set, wherein a second sun gear is the fourth rotation element, a second planet carrier is the fifth rotation element, and a second ring gear is the sixth rotation element.", "In various embodiments, the fourth rotation shaft may be fixedly connected to the second input shaft, the second rotation shaft may be fixedly connected to the first input shaft and selectively connected to a transmission housing, and the first rotation shaft may be selectively connected to the transmission housing and fixedly connected to the first motor/generator.", "The power transmission system may further include a first clutch disposed between an engine output shaft and the second input shaft, a second clutch disposed between the engine output shaft and the first input shaft, a first brake disposed between the first rotation shaft and the transmission housing, and a second brake disposed between the second rotation shaft and the transmission housing.", "The power transmission system may further include a second motor/generator fixedly connected to the fourth rotation shaft.", "In various embodiments, the fourth rotation shaft may be fixedly connected to the second input shaft, the second rotation shaft may be fixedly connected to the first input shaft, selectively connected to a transmission housing, and fixedly connected to the first motor/generator, and the first rotation shaft may be selectively connected to the transmission housing.", "The power transmission system may further include a first clutch disposed between an engine output shaft and the second input shaft, a second clutch disposed between the engine output shaft and the first input shaft, a first brake disposed between the first rotation shaft and the transmission housing, and a second brake disposed between the second rotation shaft and the transmission housing.", "The power transmission system may further include a second motor/generator fixedly connected to the fourth rotation shaft.", "According to various aspects of the present invention, a power transmission system of a vehicle may include an engine output shaft transmitting torque of an engine, an output shaft outputting torque, a first planetary gear set including first, second, and third rotation elements, a second planetary gear set including fourth, fifth, and sixth rotation elements, a first rotation shaft fixedly connected to the first rotation element, fixedly connected to a first motor/generator, and selectively connected to a transmission housing, a second rotation shaft fixedly connected to the second rotation element, fixedly connected to the sixth rotation element, selectively connected to the transmission housing, and selectively connected to the engine output shaft, a third rotation shaft fixedly connected to the third rotation element, fixedly connected to the fifth rotation element, and fixedly connected to the output shaft, and a fourth rotation shaft fixedly connected to the fourth rotation shaft and selectively connected to the engine output shaft.", "The first planetary gear set may be a single pinion planetary gear set, wherein a first sun gear is the first rotation element, a first planet carrier is the second rotation element, and a first ring gear is the third rotation element, and the second planetary gear set may be a single pinion planetary gear set, wherein a second sun gear is the fourth rotation element, a second planet carrier is the fifth rotation element, and a second ring gear is the sixth rotation element.", "The power transmission system may further include a first clutch selectively connecting the engine output shaft to the fourth rotation shaft, a second clutch selectively connecting the engine output shaft to the second rotation shaft, a first brake selectively connecting the first rotation shaft to the transmission housing, and a second brake selectively connecting the second rotation shaft to the transmission housing.", "The power transmission system may further include a second motor/generator fixedly connected to the fourth rotation shaft.", "According to various aspects of the present invention, a power transmission system of a vehicle may include an engine output shaft transmitting torque of an engine, an output shaft outputting torque, a first planetary gear set including first, second, and third rotation elements, a second planetary gear set including fourth, fifth, and sixth rotation elements, a first rotation shaft fixedly connected to the first rotation element and selectively connected to a transmission housing, a second rotation shaft fixedly connected to the second rotation element, fixedly connected to the sixth rotation element, selectively connected to the transmission housing, selectively connected to the engine output shaft, and fixedly connected to the first motor/generator, a third rotation shaft fixedly connected to the third rotation element, fixedly connected to the fifth rotation element, and fixedly connected to the output shaft, and a fourth rotation shaft fixedly connected to the fourth rotation shaft and selectively connected to the engine output shaft.", "The first planetary gear set may be a single pinion planetary gear set, wherein a first sun gear is the first rotation element, a first planet carrier is the second rotation element, and a first ring gear is the third rotation element, and the second planetary gear set may be a single pinion planetary gear set, wherein a second sun gear is the fourth rotation element, a second planet carrier is the fifth rotation element, and a second ring gear is the sixth rotation element.", "The power transmission system may further include a first clutch selectively connecting the engine output shaft to the fourth rotation shaft, a second clutch selectively connecting the engine output shaft to the second rotation shaft, a first brake selectively connecting the first rotation shaft to the transmission housing, and a second brake selectively connecting the second rotation shaft to the transmission housing.", "The power transmission system may further include a second motor/generator fixedly connected to the first rotation shaft.", "The various embodiments of the present invention may achieve four fixed speed stages and may change gear ratios continuously using a motor by combining input devices being a dual clutch, a speed change portion including planetary gear sets and friction elements, and a motor/generator enabling of driving and regenerative braking.", "Therefore, power delivery efficiency may be enhanced and marketability of the vehicle may be improved.", "In addition, a length of a transmission may be shortened by reducing a space at which a conventional torque converter exists, and driving loss by the torque converter may be reduced.", "In addition, since coasting energy can be used for regenerative braking and generating electricity by the motor/generator, fuel consumption may be greatly improved.", "It is understood that the term “vehicle” or “vehicular” or other similar terms as used herein is inclusive of motor vehicles in general such as passenger automobiles including sports utility vehicles (SUV), buses, trucks, various commercial vehicles, watercraft including a variety of boats and ships, aircraft, and the like, and includes hybrid vehicles, electric vehicles, plug-in hybrid electric vehicles, hydrogen-powered vehicles and other alternative fuel vehicles (e.g., fuel derived from resources other than petroleum).", "As referred to herein, a hybrid vehicle is a vehicle that has two or more sources of power, for example, both gasoline-powered and electric-powered vehicles.", "The methods and apparatuses of the present invention have other features and advantages which will be apparent from or are set forth in more detail in the accompanying drawings, which are incorporated herein, and the following Detailed Description, which together serve to explain certain principles of the present invention." ], [ "CROSS-REFERENCE TO RELATED APPLICATION The present application claims priority to Korean Patent Application No.", "10-2015-0167975, filed Nov. 27, 2015, the entire contents of which is incorporated herein for all purposes by this reference.", "BACKGROUND OF THE INVENTION Field of the Invention The present invention relates to a power transmission system of a vehicle.", "More particularly, the present invention relates to a power transmission system of a vehicle that enhances power delivery efficiency and improves marketability of the vehicle by achieving at least four fixed speed stages and enabling continuous changing of a gear ratio using a motor.", "Description of Related Art Environmental-friendliness of vehicles is a very important technology on which future survival of the motor industry is dependent.", "Vehicle makers are focusing on development of environmentally-friendly vehicles so as to meet environment and fuel consumption regulations.", "Therefore, vehicle manufacturers have been developing future vehicles such as electric vehicles (EV), hybrid electric vehicles (HEV), and fuel cell electric vehicles (FCEV).", "Since the future vehicles have technical restrictions such as weight and cost, vehicle manufacturers focus on hybrid electric vehicles for meeting exhaust gas regulations and improving fuel consumption performance and are competing desperately to put the hybrid electric vehicles to practical use.", "The hybrid electric vehicles are vehicles using at least two power sources, and the at least two power sources can be combined in various ways.", "Typically, the hybrid electric vehicles use gasoline engines or diesel engines using fossil fuel and motor/generators driven by electrical energy.", "The hybrid electric vehicle uses the motor/generator having relatively improved low-speed torque characteristics as a main power source at a low-speed and uses an engine having relatively improved high-speed torque characteristics as a main power source at a high-speed.", "Since the hybrid electric vehicle stops operation of the engine using fossil fuel and uses the motor/generator at a low-speed region, fuel consumption may be improved and exhaust gas may be reduced.", "The above information disclosed in this Background section is only for enhancement of understanding of the background of the invention and therefore it may contain information that does not form the prior art that is already known in this country to a person of ordinary skill in the art.", "BRIEF SUMMARY Various aspects of the present invention are directed to providing a power transmission system of a vehicle having advantages of enhancing power delivery efficiency by achieving at least four fixed speed stages and enabling continuous changing of a gear ratio using a motor.", "According to various aspects of the present invention, a power transmission system of a vehicle may include an output shaft outputting torque, a first planetary gear set including first, second, and third rotation elements, a second planetary gear set including fourth, fifth, and sixth rotation elements, a first rotation shaft fixedly connected to the first rotation element, a second rotation shaft fixedly connected to the second rotation element and fixedly connected to the sixth rotation element, a third rotation shaft fixedly connected to the third rotation element, fixedly connected to the fifth rotation element, and fixedly connected to the output shaft, a fourth rotation shaft fixedly connected to the fourth rotation element, and a first motor/generator fixedly connected to the first rotation shaft or the second rotation shaft.", "The first planetary gear set may be a single pinion planetary gear set, wherein a first sun gear is the first rotation element, a first planet carrier is the second rotation element, and a first ring gear is the third rotation element, and the second planetary gear set may be a single pinion planetary gear set, wherein a second sun gear is the fourth rotation element, a second planet carrier is the fifth rotation element, and a second ring gear is the sixth rotation element.", "In various embodiments, the fourth rotation shaft may be fixedly connected to the second input shaft, the second rotation shaft may be fixedly connected to the first input shaft and selectively connected to a transmission housing, and the first rotation shaft may be selectively connected to the transmission housing and fixedly connected to the first motor/generator.", "The power transmission system may further include a first clutch disposed between an engine output shaft and the second input shaft, a second clutch disposed between the engine output shaft and the first input shaft, a first brake disposed between the first rotation shaft and the transmission housing, and a second brake disposed between the second rotation shaft and the transmission housing.", "The power transmission system may further include a second motor/generator fixedly connected to the fourth rotation shaft.", "In various embodiments, the fourth rotation shaft may be fixedly connected to the second input shaft, the second rotation shaft may be fixedly connected to the first input shaft, selectively connected to a transmission housing, and fixedly connected to the first motor/generator, and the first rotation shaft may be selectively connected to the transmission housing.", "The power transmission system may further include a first clutch disposed between an engine output shaft and the second input shaft, a second clutch disposed between the engine output shaft and the first input shaft, a first brake disposed between the first rotation shaft and the transmission housing, and a second brake disposed between the second rotation shaft and the transmission housing.", "The power transmission system may further include a second motor/generator fixedly connected to the fourth rotation shaft.", "According to various aspects of the present invention, a power transmission system of a vehicle may include an engine output shaft transmitting torque of an engine, an output shaft outputting torque, a first planetary gear set including first, second, and third rotation elements, a second planetary gear set including fourth, fifth, and sixth rotation elements, a first rotation shaft fixedly connected to the first rotation element, fixedly connected to a first motor/generator, and selectively connected to a transmission housing, a second rotation shaft fixedly connected to the second rotation element, fixedly connected to the sixth rotation element, selectively connected to the transmission housing, and selectively connected to the engine output shaft, a third rotation shaft fixedly connected to the third rotation element, fixedly connected to the fifth rotation element, and fixedly connected to the output shaft, and a fourth rotation shaft fixedly connected to the fourth rotation shaft and selectively connected to the engine output shaft.", "The first planetary gear set may be a single pinion planetary gear set, wherein a first sun gear is the first rotation element, a first planet carrier is the second rotation element, and a first ring gear is the third rotation element, and the second planetary gear set may be a single pinion planetary gear set, wherein a second sun gear is the fourth rotation element, a second planet carrier is the fifth rotation element, and a second ring gear is the sixth rotation element.", "The power transmission system may further include a first clutch selectively connecting the engine output shaft to the fourth rotation shaft, a second clutch selectively connecting the engine output shaft to the second rotation shaft, a first brake selectively connecting the first rotation shaft to the transmission housing, and a second brake selectively connecting the second rotation shaft to the transmission housing.", "The power transmission system may further include a second motor/generator fixedly connected to the fourth rotation shaft.", "According to various aspects of the present invention, a power transmission system of a vehicle may include an engine output shaft transmitting torque of an engine, an output shaft outputting torque, a first planetary gear set including first, second, and third rotation elements, a second planetary gear set including fourth, fifth, and sixth rotation elements, a first rotation shaft fixedly connected to the first rotation element and selectively connected to a transmission housing, a second rotation shaft fixedly connected to the second rotation element, fixedly connected to the sixth rotation element, selectively connected to the transmission housing, selectively connected to the engine output shaft, and fixedly connected to the first motor/generator, a third rotation shaft fixedly connected to the third rotation element, fixedly connected to the fifth rotation element, and fixedly connected to the output shaft, and a fourth rotation shaft fixedly connected to the fourth rotation shaft and selectively connected to the engine output shaft.", "The first planetary gear set may be a single pinion planetary gear set, wherein a first sun gear is the first rotation element, a first planet carrier is the second rotation element, and a first ring gear is the third rotation element, and the second planetary gear set may be a single pinion planetary gear set, wherein a second sun gear is the fourth rotation element, a second planet carrier is the fifth rotation element, and a second ring gear is the sixth rotation element.", "The power transmission system may further include a first clutch selectively connecting the engine output shaft to the fourth rotation shaft, a second clutch selectively connecting the engine output shaft to the second rotation shaft, a first brake selectively connecting the first rotation shaft to the transmission housing, and a second brake selectively connecting the second rotation shaft to the transmission housing.", "The power transmission system may further include a second motor/generator fixedly connected to the first rotation shaft.", "The various embodiments of the present invention may achieve four fixed speed stages and may change gear ratios continuously using a motor by combining input devices being a dual clutch, a speed change portion including planetary gear sets and friction elements, and a motor/generator enabling of driving and regenerative braking.", "Therefore, power delivery efficiency may be enhanced and marketability of the vehicle may be improved.", "In addition, a length of a transmission may be shortened by reducing a space at which a conventional torque converter exists, and driving loss by the torque converter may be reduced.", "In addition, since coasting energy can be used for regenerative braking and generating electricity by the motor/generator, fuel consumption may be greatly improved.", "It is understood that the term “vehicle” or “vehicular” or other similar terms as used herein is inclusive of motor vehicles in general such as passenger automobiles including sports utility vehicles (SUV), buses, trucks, various commercial vehicles, watercraft including a variety of boats and ships, aircraft, and the like, and includes hybrid vehicles, electric vehicles, plug-in hybrid electric vehicles, hydrogen-powered vehicles and other alternative fuel vehicles (e.g., fuel derived from resources other than petroleum).", "As referred to herein, a hybrid vehicle is a vehicle that has two or more sources of power, for example, both gasoline-powered and electric-powered vehicles.", "The methods and apparatuses of the present invention have other features and advantages which will be apparent from or are set forth in more detail in the accompanying drawings, which are incorporated herein, and the following Detailed Description, which together serve to explain certain principles of the present invention.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a schematic diagram of a first exemplary power transmission system of a vehicle according to the present invention.", "FIG.", "2 is an operational chart of control elements at each speed stage applied to the first exemplary power transmission system of the vehicle according to the present invention.", "FIG.", "3 is a lever diagram at a first forward speed stage in the first exemplary power transmission system of the vehicle according to the present invention.", "FIG.", "4 is a lever diagram at a second forward speed stage in the first exemplary power transmission system of the vehicle according to the present invention.", "FIG.", "5 is a lever diagram at a third forward speed stage in the first exemplary power transmission system of the vehicle according to the present invention.", "FIG.", "6 is a lever diagram at a fourth forward speed stage in the first exemplary power transmission system of the vehicle according to the present invention.", "FIG.", "7 is a lever diagram at a reverse speed stage in the first exemplary power transmission system of the vehicle according to the present invention.", "FIG.", "8 is a schematic diagram of a second exemplary power transmission system of a vehicle according to the present invention.", "FIG.", "9 is an operational chart of control elements at each speed stage applied to the second exemplary power transmission system of the vehicle according to the present invention.", "FIG.", "10 is a lever diagram at a first forward speed stage in the second exemplary power transmission system of the vehicle according to the present invention.", "FIG.", "11 is a lever diagram at a second forward speed stage in the second exemplary power transmission system of the vehicle according to the present invention.", "FIG.", "12 is a lever diagram at a third forward speed stage in the second exemplary power transmission system of the vehicle according to the present invention.", "FIG.", "13 is a lever diagram at a fourth forward speed stage in the second exemplary power transmission system of the vehicle according to the present invention.", "FIG.", "14 is a lever diagram at a reverse speed stage in the second exemplary power transmission system of the vehicle according to the present invention.", "FIG.", "15 is a schematic diagram of a third exemplary power transmission system of a vehicle according to the present invention.", "FIG.", "16 is an operation chart of control elements at each speed stage applied to the third exemplary power transmission system of the vehicle according to the present invention.", "FIG.", "17 is a lever diagram at each speed stage in the third exemplary power transmission system of the vehicle according to the present invention.", "FIG.", "18 is a schematic diagram of a fourth exemplary power transmission system of a vehicle according to the present invention.", "FIG.", "19 is an operation chart of control elements at each speed stage applied to the fourth exemplary power transmission system of the vehicle according to the present invention.", "FIG.", "20 is a lever diagram at each speed stage in the fourth exemplary power transmission system of the vehicle according to the present invention.", "It should be understood that the appended drawings are not necessarily to scale, presenting a somewhat simplified representation of various features illustrative of the basic principles of the invention.", "The specific design features of the present invention as disclosed herein, including, for example, specific dimensions, orientations, locations, and shapes will be determined in part by the particular intended application and use environment.", "DETAILED DESCRIPTION Reference will now be made in detail to various embodiments of the present invention(s), examples of which are illustrated in the accompanying drawings and described below.", "While the invention(s) will be described in conjunction with exemplary embodiments, it will be understood that the present description is not intended to limit the invention(s) to those exemplary embodiments.", "On the contrary, the invention(s) is/are intended to cover not only the exemplary embodiments, but also various alternatives, modifications, equivalents and other embodiments, which may be included within the spirit and scope of the invention as defined by the appended claims.", "FIG.", "1 is a schematic diagram of a power transmission system of a vehicle according to various embodiments of the present invention.", "Referring to FIG.", "1, a power transmission system of a vehicle according to various embodiments of the present invention uses an engine ENG and a first motor/generator MG1 as power sources, and includes first and second planetary gear sets PG1 and PG2 disposed on the same axis, first and second input shafts IS1 and IS2, an output shaft OS, four rotation shafts TM1 to TM4 connected to at least one of rotation elements of the first and second planetary gear sets PG1 and PG2, and four control elements C1, C2, BI, and B2.Torque input from the first and second input shafts IS1 and IS2 and a first motor shaft MS1 is changed through the first and second planetary gear sets PG1 and PG2, and the changed torque is output through the output shaft OS.", "The first input shaft IS1 and the first motor shaft MS1 are solid shafts and disposed on the same axis.", "The second input shaft IS2 is a hollow shaft and encloses the first input shaft IS1 without rotational interference therewith.", "In addition, the first and second input shafts IS1 and IS2 are selectively connected to an engine output shaft EOS through first and second clutches C1 and C2.That is, the first input shaft IS1 is selectively connected to the engine output shaft EOS through the second clutch C2, and the second input shaft IS2 is selectively connected to the engine output shaft EOS through the first clutch C1.The engine ENG is a main power source, and a gasoline engine or a diesel engine using conventional fossil fuel may be used as the engine.", "The first motor/generator MG1 functions as a motor and a generator, and includes a first stator ST1 fixed to a transmission housing H and a first rotor RT1 rotatably supported in a radial interior of the first stator ST1.The first rotor RT1 is fixedly connected to the first motor shaft MS1.A speed change portion including the first and second planetary gear sets PG1 and PG2 is disposed between the engine ENG and the first motor/generator MG1.The first planetary gear set PG1 is disposed close to the first motor/generator MG1 and the second planetary gear set PG2 is disposed close to the engine ENG.", "The first planetary gear set PG1 is a single pinion planetary gear set and includes a first sun gear S1, a first planet carrier PC1 rotatably supporting a first pinion P1 that is externally meshed with the first sun gear S1, and a first ring gear R1 that is internally meshed with the first pinion P1 respectively as first, second, and third rotation elements N1, N2, and N3.The second planetary gear set PG2 is a single pinion planetary gear set and includes a second sun gear S2, a second planet carrier PC2 rotatably supporting a second pinion P2 that is externally meshed with the second sun gear S2, and a second ring gear R2 that is internally meshed with the second pinion P2 respectively as fourth, fifth, and sixth rotation elements N4, N5, and N6.Since the second rotation element N2 is directly connected to the sixth rotation element N6 and the third rotation element N3 is directly connected to the fifth rotation element N5, the first and second planetary gear sets PG1 and PG2 includes four rotation shafts TM1 to TM4.The four rotation shafts TM1 to TM4 will be described in detail.", "The first rotation shaft TM1 is fixedly connected to the first rotation element N1 (first sun gear S1), is fixedly connected to the first motor shaft MS1, and is selectively connected to the transmission housing H. The second rotation shaft TM2 fixedly connects the second rotation element N2 (first planet carrier PC1) with the sixth rotation element N6 (second ring gear R2), is fixedly connected to the first input shaft IS1 so as to be selectively connected to the engine output shaft EOS, is selectively connected to the transmission housing H. The third rotation shaft TM3 fixedly connects the third rotation element N3 (first ring gear R1) with the fifth rotation element N5 (second planet carrier PC2), and is fixedly connected to an output gear OG through the output shaft OS so as to be operated as an output element continuously.", "The four rotation shafts fixedly connects a plurality of rotation elements among the rotation elements of the planetary gear sets PG1 and PG2 with each other, are rotation members that are connected to any one rotation element and rotate with the any one rotation element to transmit torque, are rotation members that selectively connects any one rotation element with the transmission housing H, or are fixing members that fixedly connect any one rotation element to the transmission housing H. Here, the term “fixedly connected” or the like means at least two members are connected to each other to continuously rotate without rotational speed difference.", "That is, at least two members that are fixedly connected to each other always rotate with the same rotation speed and in the same rotation direction.", "Here, the term “selectively connected” or the like means a plurality of shafts including the input shaft and the output shaft are connectable to each other through at least one of the control elements to rotate with the same rotation speed and the same rotation direction, or are connectable to the transmission housing through at least one of the control elements to be fixed to the transmission housing.", "In other words, in a case that the control element selectively connects a plurality of shafts to each other, the plurality of shafts rotate with the same rotation speed and in the same rotation direction when the control element operates, but the plurality of shafts are disconnected from each other when the control element is released.", "In addition, in a case that the control element selectively connects any one shaft to the transmission housing, the corresponding shaft is fixedly connected to the transmission housing when the control element operates, but the corresponding shaft is rotatable when the control element is released.", "In addition, the description that a rotation shaft or an input shaft is connected to a motor/generator means the corresponding shaft is fixedly connected to a rotor of the motor/generator.", "Arrangement of the two clutches C1 and C2 and the two brakes B1 and B2 will be described in detail.", "The first clutch C1 is disposed between the engine output shaft EOS and the second input shaft IS2 and selectively connects the engine output shaft EOS with the second input shaft IS2.The second clutch C2 is disposed between the engine output shaft EOS and the first input shaft IS1 and selectively connects the engine output shaft EOS with the first input shaft IS1.The first brake B1 is disposed between the first rotation shaft TM1 and the transmission housing H and causes the first rotation shaft TM1 to be operated as a selective fixed element.", "The second brake B2 is disposed between the second rotation shaft TM2 and the transmission housing H and causes the second rotation shaft TM2 to be operated as a selective fixed element.", "FIG.", "2 is an operational chart of control elements at each speed stage applied to a power transmission system of a vehicle according to various embodiments of the present invention.", "As shown in FIG.", "2, operation of the control elements at fixed speed stages will be described in detail.", "The first clutch C1 and the second brake B2 are operated at a first forward speed stage 1ST.", "The first clutch C1 and the first brake B1 are operated at a second forward speed stage 2ND.", "The first clutch C1 and the second clutch C2 are operated at a third forward speed stage 3RD.", "The second clutch C2 and the first brake B1 are operated at a fourth forward speed stage 4TH.", "The second brake B2 is operated at a reverse speed stage REV.", "In this case, the first motor/generator MG1 is also operated.", "FIG.", "3 is a lever diagram at a first forward speed stage in a power transmission system of a vehicle according to various embodiments of the present invention.", "Referring to FIG.", "3, the first clutch C1 and the second brake B2 are operated at the first forward speed stage 1ST.", "In addition, in a state that torque of the engine ENG is input to the fourth rotation shaft TM4 by operation of the first clutch C1, the second rotation shaft TM2 is operated as the fixed element by operation of the second brake B2.Therefore, the torque of the engine ENG is shifted into the first forward speed stage, and the first forward speed stage is output through the third rotation shaft TM3 that is the output element.", "The first motor/generator MG1 can generate electricity and can assist torque through inverse rotation of the first motor/generator MG1 at the first forward speed stage 1ST.", "Continuous change of gear ratio by the first motor/generator MG1 at the first forward speed stage 1ST can be changed according to whether the second brake B2 is operated.", "In a state that the second brake B2 is operated, the torque of the engine ENG is controlled not to be input to the speed change portion and a gear ratio can be increased by controlling an inverse rotation speed of the first motor/generator MG1.In a state that the second brake B2 is not operated, the torque of the engine ENG is controlled to be input to the speed change portion and a gear ratio can be decreased by controlling the inverse rotation speed of the first motor/generator MG1.FIG.", "4 is a lever diagram at a second forward speed stage in a power transmission system of a vehicle according to various embodiments of the present invention.", "Referring to FIG.", "4, the first clutch C1 and the first brake B1 are operated at the second forward speed stage 2ND.", "In a state that the torque of the engine ENG is input to the fourth rotation shaft TM4 by operation of the first clutch C1, the first rotation shaft TM1 is operated as the fixed element by operation of the first brake B1.Therefore, the torque of the engine ENG is shifted into the second forward speed stage, and the second forward speed stage is output through the third rotation shaft TM3 that is the output element.", "If a gear ratio is to be changed continuously by the first motor/generator MG1 at the second forward speed stage 2ND, the first brake B1 is released and the torque of the engine ENG is controlled to be input to the speed change portion.", "In this case, the gear ratio can be changed by controlling a rotation speed of the first motor/generator MG1.FIG.", "5 is a lever diagram at a third forward speed stage in a power transmission system of a vehicle according to various embodiments of the present invention.", "Referring to FIG.", "5, the first clutch C1 and the second clutch C2 are operated at the third forward speed stage 3RD.", "The torque of the engine ENG is simultaneously input to the fourth rotation shaft TM4 and the second rotation shaft TM2 by operation of the first clutch C1 and the second clutch C2.In this case, the first and second planetary gear sets PG1 and PG2 become lock-up states.", "Therefore, the torque of the engine ENG is shifted into the third forward speed stage, and the third forward speed stage is output through the third rotation shaft TM3 that is the output element.", "The same rotation speed with the engine ENG is output at the third forward speed stage.", "In addition, the first motor/generator MG1 can assist torque by rotating in a positive direction at the third forward speed stage.", "FIG.", "6 is a lever diagram at a fourth forward speed stage in a power transmission system of a vehicle according to various embodiments of the present invention.", "Referring to FIG.", "6, the second clutch C2 and the first brake B1 are operated at the fourth forward speed stage 4TH.", "In a state that the torque of the engine ENG is input to the second rotation shaft TM2 by operation of the second clutch C2, the first rotation shaft TM1 is operated as the fixed element by operation of the first brake B1.Therefore, the torque of the engine ENG is shifted into the fourth forward speed stage, and the fourth forward speed stage is output through the third rotation shaft TM3 that is the output element.", "If a gear ratio is to be continuously changed by the first motor/generator MG1 at the fourth forward speed stage 4TH, the first brake B1 is released and the torque of the engine ENG is controlled to be input to the speed change portion.", "At this state, the gear ratio can be changed by controlling the inverse or the positive rotation speed of the first motor/generator MG1.Referring to FIG.", "7, in a stopped state of the engine ENG, the second brake B2 is operated and the first motor/generator MG1 is also operated at the reverse speed stage REV.", "In a state that torque of the first motor/generator MG1 is input to the first rotation shaft TM1, the second rotation shaft TM2 is operated as the fixed element by operation of the second brake B2 and the inverse rotation speed is output.", "That is, the torque of the first motor/generator MG1 is shifted into the reverse speed stage, and the reverse speed stage is output through the third rotation shaft TM3 that is the output element.", "The power transmission system according to various embodiments of the present invention achieves four fixed speed stages and changes gear ratios continuously using a motor by combining input devices including a dual clutch, a speed change portion including planetary gear sets and control elements, and a first motor/generator enabling of driving and regenerative braking.", "Therefore, power delivery efficiency may be enhanced and marketability of the vehicle may be improved.", "In addition, a length of a transmission may be shortened by reducing a space at which a conventional torque converter exists, and driving loss by the torque converter may be reduced.", "In addition, since coasting energy can be used for regenerative braking and generating electricity by the first motor/generator, fuel consumption may be greatly improved.", "FIG.", "8 is a schematic diagram of a power transmission system of a vehicle according to various embodiments of the present invention.", "Referring to FIG.", "8, a power transmission system of a vehicle according to various embodiments of the present invention uses an engine ENG and first and second motor/generators MG1 and MG2 as power sources, and includes first and second planetary gear sets PG1 and PG2, an output shaft OS, four rotation shafts TM1 to TM4 connected to at least one of rotation elements of the first and second planetary gear sets PG1 and PG2, four control elements C1, C2, B1, and B2, and a transmission housing H. Torque of the engine ENG and torque of the first and the second motor/generator MG1 and MG2 is changed through the first and second planetary gear sets PG1 and PG2, and the changed torque is output through the output shaft OS.", "The power transmission system of the vehicle illustrated in FIG.", "8 is formed by adding the second motor/generator MG 2 to the power transmission system of the vehicle illustrated in FIG.", "1.The second motor/generator MG2 functions as a motor and a generator, and includes a second stator ST2 fixed to the transmission housing H and a second rotor RT2 rotatably supported in a radial interior of the second stator ST2.The second rotor RT2 is fixedly connected to a second motor shaft MS2.In addition, the second motor shaft MS2 is fixedly connected to the second input shaft IS2.FIG.", "9 is an operational chart of control elements at each speed stage applied to a power transmission system of a vehicle according to various embodiments of the present invention, and FIG.", "10 to FIG.", "14 are lever diagrams at fixed speed stages.", "Referring to FIG.", "9, the first clutch C1 and the second brake B2 are operated at the first forward speed stage 1ST.", "As shown in FIG.", "10, in a state that torque of the engine ENG is input to the fourth rotation shaft TM4 by operation of the first clutch C1, the second rotation shaft TM2 is operated as the fixed element by operation of the second brake B2.Therefore, the four rotation shafts form a first shift line SP1 and D1 is output through the third rotation shaft TM3.An electric-continuously variable transmission (e-CVT) can be achieved at the first forward speed stage.", "At an e-CVT mode, the second brake B2 is released and rotation speed of the engine ENG can be increased or decreased by operation of the first motor/generator MG1.At this time, torque can be assisted by the second motor/generator MG2.Referring to FIG.", "9, the first clutch C1 and the first brake B1 are operated at the second forward speed stage 2ND.", "As shown in FIG.", "11, in a state that the torque of the engine ENG is input to the fourth rotation shaft TM4 by operation of the first clutch C1, the first rotation shaft TM1 is operated as the fixed element by operation of the first brake B1.Therefore, the four rotation shafts form a second shift line SP2 and D2 is output through the third rotation shaft TM3.The e-CVT can be achieved at the second forward speed stage.", "At the e-CVT mode, the first brake B1 is released and the rotation speed of the engine ENG can be increased or decreased by operation of the first motor/generator MG1.At this time, torque can be assisted by the second motor/generator MG2.Referring to FIG.", "9, the first clutch C1 and the second clutch C2 are operated at the third forward speed stage 3RD.", "As shown in FIG.", "12, the torque of the engine ENG is simultaneously input to the fourth rotation shaft TM4 and the second rotation shaft TM2 by operation of the first clutch C1 and the second clutch C2.In this case, the first and second planetary gear sets PG1 and PG2 become lock-up states.", "Therefore, the four rotation shafts form a third shift line SP3 and D3 is output through the third rotation shaft TM3.The e-CVT can be achieved at the first forward speed stage.", "At the e-CVT mode, the first clutch C1 is released, a ratio of input/output is changed by increasing or decreasing rotation speed of the second motor/generator MG2, and torque can be assisted by using any one of the first and the second motor/generators MG1 and MG2.Referring to FIG.", "9, the second clutch C2 and the first brake B1 are operated at the fourth forward speed stage 4TH.", "As shown in FIG.", "13, in a state that the torque of the engine ENG is input to the second rotation shaft TM2 by operation of the second clutch C2, the first rotation shaft TM1 is operated as the fixed element by operation of the first brake B1.Therefore, the four rotation shafts form a fourth shift line SP4 and D4 is output through the third rotation shaft TM3.The e-CVT can be achieved at the fourth forward speed stage.", "At the e-CVT mode, the first brake B1 is released and the rotation speed of the engine ENG can be increased or decreased by operation of the first motor/generator MG1 or the second motor/generator MG2.At this time, torque can be assisted by the second motor/generator MG2 or the first motor/generator MG1.The reverse speed stage REV can be achieved in three ways.", "In the first way, only the torque of the first motor/generator MG1 is used.", "In a state that the torque of the first motor/generator MG1 is input to the first rotation shaft TM1, the second rotation shaft TM2 is operated as the fixed element by operation of the second brake B2.Therefore, the four rotation shafts form a reverse shift line RSP and REV is output through the third rotation shaft TM3.In the second way, only the torque of the second motor/generator MG2 is used.", "In a state that the torque of the second motor/generator TM2 is input to the fourth rotation shaft TM4, the second rotation shaft TM2 is operated as the fixed element by operation of the second brake B2.Therefore, the four rotation shafts form the reverse shift line RSP and the REV is output through the third rotation shaft TM3.In the third way, the torque of the engine ENG is used.", "In this case, the second brake B2 is released and the reverse speed stage can be achieved by inverse rotation of the first motor/generator MG1.At this time, torque can be assisted by the second motor/generator MG2.The power transmission system of a vehicle according to various embodiments of the present invention can achieve two electric vehicle modes EV1 and EV2.In a state that the second brake B2 is operated, the first motor/generator MG1 is operated, the second motor/generator MG2 is operated, or both of the first and the second motor/generator MG1 and MG2 are operated at the first electric vehicle mode EV1.In a state that the first brake B1 is operated, the second motor/generator MG2 is operated at the second electric vehicle mode EV2.FIG.", "15 is a schematic diagram of a power transmission system of a vehicle according to various embodiments of the present invention.", "Referring to FIG.", "15, a power transmission system of a vehicle according to various embodiments of the present invention uses an engine ENG and a first motor/generators MG1 as power sources, and includes first and second planetary gear sets PG1 and PG2, an output shaft OS, four rotation shafts TM1 to TM4 connected to at least one of rotation elements of the first and second planetary gear sets PG1 and PG2, four control elements C1, C2, B1, and B2, and a transmission housing H. Torque of the engine ENG and torque of the first motor/generator MG1 is changed through the first and second planetary gear sets PG1 and PG2, and the changed torque is output through the output shaft OS.", "The power transmission system illustrated in FIG.", "15 is similar to that illustrated in FIG.", "1, but a rotation shaft fixedly connected to the first motor/generator MG1 is different therebetween.", "That is, the first motor/generator MG1 is fixedly connected to the first rotation shaft TM 1 in the power transmission system illustrated in FIG.", "1, but the first motor/generator MG1 is fixedly connected to the second rotation shaft TM2 in the power transmission system illustrated in FIG.", "15.FIG.", "16 is an operational chart of control elements at each speed stage applied to a power transmission system of a vehicle according to various embodiments of the present invention, and FIG.", "17 is a lever diagram at fixed speed stages.", "Referring to FIG.", "16, the first clutch C1 and the second brake B2 are operated at the first forward speed stage 1ST.", "As shown in FIG.", "17, in a state that torque of the engine ENG is input to the fourth rotation shaft TM4 by operation of the first clutch C1, the second rotation shaft TM2 is operated as the fixed element by operation of the second brake B2.Therefore, the four rotation shafts form a first shift line SP1 and D1 is output through the third rotation shaft TM3.An electric-continuously variable transmission (e-CVT) can be achieved at the first forward speed stage.", "At an e-CVT mode, the second brake B2 is released and rotation speed of the engine ENG can be controlled by operation of the first motor/generator MG1.Referring to FIG.", "16, the first clutch C1 and the first brake B1 are operated at the second forward speed stage 2ND.", "As shown in FIG.", "17, in a state that the torque of the engine ENG is input to the fourth rotation shaft TM4 by operation of the first clutch C1, the first rotation shaft TM1 is operated as the fixed element by operation of the first brake B 1.Therefore, the four rotation shafts form a second shift line SP2 and D2 is output through the third rotation shaft TM3.The e-CVT can be achieved in two ways at the second forward speed stage.", "In the first way, the rotation speed of the engine ENG can be controlled by operation of the first motor/generator MG1 in a state that the first brake is operated.", "In the second way, the rotation speed of the engine ENG can be controlled by operation of the first motor/generator in a state that the first brake B1 is released.", "Referring to FIG.", "16, the first clutch C1 and the second clutch C2 are operated at the third forward speed stage 3RD.", "As shown in FIG.", "17, the torque of the engine ENG is simultaneously input to the fourth rotation shaft TM4 and the second rotation shaft TM2 by operation of the first clutch C1 and the second clutch C2.In this case, the first and second planetary gear sets PG1 and PG2 become lock-up states.", "Therefore, the four rotation shafts form a third shift line SP3 and D3 is output through the third rotation shaft TM3.Since the first and second planetary gear sets PG1 and PG2 are lock-up states at the third forward speed stage, the torque of the first motor/generator MG1 can assist the torque of the engine ENG.", "Referring to FIG.", "16, the second clutch C2 and the first brake B1 are operated at the fourth forward speed stage 4TH.", "As shown in FIG.", "17, in a state that the torque of the engine ENG is input to the second rotation shaft TM2 by operation of the second clutch C2, the first rotation shaft TM1 is operated as the fixed element by operation of the first brake B 1.Therefore, the four rotation shafts form a fourth shift line SP4 and D4 is output through the third rotation shaft TM3.The e-CVT can be achieved at the fourth forward speed stage.", "At the e-CVT mode, the rotation speed of the engine ENG can be controlled by operation of the first motor/generator MG1 without release of the first brake B1.Torque of the engine ENG and torque of the first motor/generator MG1 is used at the reverse speed stage REV.", "In a state that the torque of the engine ENG is input to the fourth rotation shaft TM4 by operation of the first clutch C1, the first motor/generator MG1 is rotated inversely.", "In this case, the four rotation shafts form a reverse shift line RSP and REV is output through the third rotation shaft TM3.At an electric vehicle EV mode, the vehicle can travel by propulsion of the first motor/generator MG1.In this case, the first motor/generator MG1 is operated in a state that the first brake B1 is operated.", "FIG.", "18 is a schematic diagram of a power transmission system of a vehicle according to various embodiments of the present invention.", "The power transmission system of the vehicle illustrated in FIG.", "18 is formed by adding the second motor/generator MG 2 to the power transmission system of the vehicle illustrated in FIG.", "15.The second motor/generator MG2 is fixedly connected to the first rotation shaft TM1.FIG.", "19 is an operational chart of control elements at each speed stage applied to a power transmission system of a vehicle according to various embodiments of the present invention, and FIG.", "20 is a lever diagram at fixed speed stages.", "Referring to FIG.", "19, the first clutch C1 and the second brake B2 are operated at the first forward speed stage 1ST.", "As shown in FIG.", "20, in a state that torque of the engine ENG is input to the fourth rotation shaft TM4 by operation of the first clutch C1, the second rotation shaft TM2 is operated as the fixed element by operation of the second brake B2.Therefore, the four rotation shafts form a first shift line SP1 and D1 is output through the third rotation shaft TM3.An e-CVT can be achieved at the first forward speed stage.", "The e-CVT can be achieved in two ways.", "In the first way, the second brake B2 is released.", "In this case, the rotation speed of the engine ENG can be controlled by operation of the first motor/generator MG1.In the second way, the second brake B2 is operated.", "In this case, the rotation speed of the engine ENG is controlled by operation of the second motor/generator MG2.Referring to FIG.", "19, the first clutch C1 and the first brake B1 are operated at the second forward speed stage 2ND.", "As shown in FIG.", "20, in a state that the torque of the engine ENG is input to the fourth rotation shaft TM4 by operation of the first clutch C1, the first rotation shaft TM1 is operated as the fixed element by operation of the first brake B1.Therefore, the four rotation shafts form a second shift line SP2 and D2 is output through the third rotation shaft TM3.The e-CVT can be achieved at the second forward speed stage.", "The e-CVT can be achieved in two ways.", "In the first way, the first brake B1 is released.", "In this case, the rotation speed of the engine ENG can be controlled by operation of the first motor/generator MG1 and the second motor/generator MG2.In the second way, the first brake B1 is operated.", "In this case, the rotation speed of the engine ENG can be controlled by operation of the first motor/generator.", "Referring to FIG.", "19, the first clutch C1 and the second clutch C2 are operated at the third forward speed stage 3RD.", "As shown in FIG.", "20, the torque of the engine ENG is simultaneously input to the fourth rotation shaft TM4 and the second rotation shaft TM2 by operation of the first clutch C1 and the second clutch C2.In this case, the first and second planetary gear sets PG1 and PG2 become lock-up states.", "Therefore, the four rotation shafts form a third shift line SP3 and D3 is output through the third rotation shaft TM3.Since the first and second planetary gear sets PG1 and PG2 are lock-up states at the third forward speed stage, the second clutch C2 is released and the third forward speed stage can be achieved only by operation of the first and second motor/generators MG1 and MG2.Referring to FIG.", "19, the second clutch C2 and the first brake B1 are operated at the fourth forward speed stage 4TH.", "As shown in FIG.", "20, in a state that the torque of the engine ENG is input to the second rotation shaft TM2 by operation of the second clutch C2, the first rotation shaft TM1 is operated as the fixed element by operation of the first brake B1.Therefore, the four rotation shafts form a fourth shift line SP4 and D4 is output through the third rotation shaft TM3.The e-CVT can be achieved at the fourth forward speed stage.", "The e-CVT can be achieved in two ways.", "In the first way, the first brake B1 is released.", "In this case, the rotation speed of the engine ENG can be controlled by operation of the first and second motor/generator MG1 and MG2.In the second way, the first brake B1 is operated.", "In this case, the rotation speed of the engine ENG can be controlled by operation of the first motor/generator MG1.The reverse speed stage REV can be achieved in three ways.", "In the first way, the torque of the engine ENG and the first motor/generator MG1 is used.", "In a state that the torque of the engine ENG is input to the fourth rotation shaft TM4 by operation of the first clutch C1, the first motor/generator MG1 is rotated inversely.", "In this case, the four rotation shafts form a first reverse shift line RSP1 and REV is output through the third rotation shaft TM3.In the second way, only the torque of the second motor/generator MG2 is used.", "If the second rotation shaft TM2 is operated as the fixed element by operation of the second brake B2, the four rotation shafts form a second reverse shift line RSP2.Therefore, the REV is output through the third rotation shaft TM3.In the third way, a third reverse shift line RSP3 can be formed only by operation of the first and second motor/generators MG1 and MG2.Therefore, the REV is output through the third rotation shaft TM3.The power transmission system of a vehicle according to various embodiments of the present invention can achieve two electric vehicle modes EV1 and EV2.In a state that the second brake B2 is operated, the second motor/generator MG2 is operated at a first electric vehicle mode EV1.In a state that the first brake B1 is operated, the second motor/generator MG2 is operated, or both of the first and the second motor/generator MG1 and MG2 are operated at the first electric vehicle mode EV1.In a state that the first brake B1 is operated, the first motor/generator MG1 is operated at the second electric vehicle mode EV2.While this invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims." ] ]
Patent_15875869
[ [ "WIRELESS ENVIRONMENTAL SENSOR", "A wireless environmental sensor or monitoring device includes a sensor configured to detect an environmental parameter.", "A radio module is configured to wirelessly communicate data corresponding to the detected environmental parameter to a remote system.", "The device also includes logic executable by a processor unit to switch the radio module between a wireless access point (AP) operating mode and a wireless client operating mode." ], [ "1.A device, comprising: a sensor configured to detect an environmental parameter; a radio module configured to wirelessly communicate data corresponding to the detected environmental parameter to a remote system; and logic executable by a processor unit of the device to switch the radio module between a wireless access point (AP) operating mode and a wireless client operating mode.", "2.The device of claim 1, wherein the logic is executable to enable wireless configuration settings of the radio module to be modified by a client device.", "3.The device of claim 1, wherein the logic is executable to, responsive to detecting wireless communication connectivity to the remote system, disable a currently active wireless AP operating mode.", "4.The device of claim 1, further comprising an input device configured to be physically actuated to enable the wireless AP operating mode.", "5.The device of claim 1, wherein the logic is executable to determine whether the device is being powered by a remote power source or a local power source.", "6.The device of claim 5, wherein, responsive to detecting that the device is being powered by the local power source, the logic is executable to invoke a first operating parameter mode for monitoring the environmental parameter according to a first setting.", "7.The device of claim 6, wherein, responsive to detecting that the device is being powered by the remote power source, change to a second operating parameter mode for monitoring the environmental parameter according to a second setting.", "8.A method, comprising: monitoring and collecting, by a sensor device, data corresponding to an environmental parameter; wirelessly communicating the data from the sensor device to a remote system; determining whether a change from local power source to a remote power source for powering the sensor device has occurred; and responsive to detecting the change, switching the sensor device from a first operating parameter mode according to a first setting to a second operating parameter mode for monitoring the environmental parameter according to a second setting.", "9.The method of claim 8, wherein the first setting monitors for a shock frequency different than a shock frequency defined by the second setting.", "10.The method of claim 8, further comprising monitoring wireless communication connectivity with the remote system.", "11.The method of claim 10, further comprising, responsive to detecting a loss of wireless communication connectivity with the remote system, automatically enable a radio module of the sensor device to operate as a wireless access point.", "12.The method of claim 8, further comprising receiving an input by the sensor device to enable a radio module of the sensor device to operate as a wireless access point.", "13.The method of claim 12, further comprising enabling wireless configuration settings of the radio module to be modified by a client device while operating as a wireless access point.", "14.A device, comprising: a sensor; a monitor module for monitoring and collecting data corresponding to an environmental parameter detected by the sensor; a radio module configured to enable wireless communication of the data to a remote system; and wherein the monitor module is configured to: operate in a first operating parameter mode according to a first setting for monitoring the environmental parameter while the device is mobile; and operate in a second operating parameter mode according to a second setting for monitoring the environmental parameter while the device is stationary.", "15.The device of claim 14, wherein the first setting monitors for a shock frequency different than a shock frequency defined by the second setting.", "16.The device of claim 14, wherein the logic is executable to monitor wireless communication connectivity with the remote system.", "17.The device of claim 16, wherein the logic is executable to, responsive to detecting a loss of wireless communication connectivity with the remote system, automatically enable the radio module to operate as a wireless access point.", "18.The device of claim 14, further comprising an input device configured to be physically actuated to enable the radio module to operate as a wireless access point.", "19.The device of claim 17, wherein the logic is executable to enable wireless configuration settings of the radio module to be modified by a client device while operating as a wireless access point.", "20.The device of claim 14, wherein the monitor module is configured to determine whether to operate in the first or second operating parameter mode based on a power supply powering the device." ], [ "<SOH> BACKGROUND <EOH>Environmental sensors such as shock sensors, temperature sensors, humidity sensors, chemical sensors, radiation sensors, and so forth, often are sometimes positioned in places that are not easily accessible and, accordingly, may be connected to monitoring systems using wireless technology.", "Examples of sensors placed in inaccessible areas monitoring static applications include shock sensors placed on drilling rigs, computer numerical control (CNC) manufacturing equipment, cranes, and so forth.", "A shock sensing unit may be remotely mounted on a piece of equipment and provided with external power.", "The remote unit then has a wireless connection to a network or base station also known as an access point.", "Typically the remote environmental sensor uses a Wi-Fi radio that may be similar to those found in a cell phone or laptop computer.", "In normal operation, the radio on the environmental sensor wirelessly reports or communicates monitored or collected data to a server or remote access point." ], [ "<SOH> BRIEF SUMMARY <EOH>According to one aspect of the present disclosure, a wireless environmental sensor or monitoring device includes a processor unit, a monitor module for monitoring and collecting data corresponding to an environmental parameter, a radio module configured to enable wireless communication of the data to a remote system, and logic executable by the processor unit to: monitor wireless communication connectivity between the radio module and the remote system; and responsive to detecting a loss of wireless communication connectivity with the remote system, automatically enable a wireless access point (AP) mode of the radio module to initiate a broadcast of a local wireless network identifier to enable a client device to wirelessly locate and connect to the sensor device.", "According to another embodiment of the present disclosure, a method and technique for wireless connectivity monitoring and resolution for a wireless environmental monitoring or sensor device includes: monitoring and collecting, by an environmental sensor device, data corresponding to an environmental parameter; wirelessly communicating the data from the environmental sensor device to a remote system; monitoring, by the environmental sensor device, wireless communication connectivity with the remote system; and responsive to detecting a loss of wireless communication connectivity with the remote system, automatically enabling a wireless access point (AP) mode of a radio module of the environmental sensor device to initiate a broadcast of a local wireless network identifier to enable a client device to wirelessly locate and connect to the environmental sensor device.", "According to yet another embodiment of the present disclosure, a wireless environmental monitoring or sensor device includes a processor unit, a monitor module for monitoring and collecting data corresponding to an environmental parameter, a radio module configured to enable wireless communication of the data to a remote system, and logic executable by the processor unit to: determine a change from local power source to a remote power source for powering the sensor device; and responsive to detecting the change, switch the monitor module to a second operating parameter mode for monitoring the environmental parameter according to a second setting." ], [ "BACKGROUND Environmental sensors such as shock sensors, temperature sensors, humidity sensors, chemical sensors, radiation sensors, and so forth, often are sometimes positioned in places that are not easily accessible and, accordingly, may be connected to monitoring systems using wireless technology.", "Examples of sensors placed in inaccessible areas monitoring static applications include shock sensors placed on drilling rigs, computer numerical control (CNC) manufacturing equipment, cranes, and so forth.", "A shock sensing unit may be remotely mounted on a piece of equipment and provided with external power.", "The remote unit then has a wireless connection to a network or base station also known as an access point.", "Typically the remote environmental sensor uses a Wi-Fi radio that may be similar to those found in a cell phone or laptop computer.", "In normal operation, the radio on the environmental sensor wirelessly reports or communicates monitored or collected data to a server or remote access point.", "BRIEF SUMMARY According to one aspect of the present disclosure, a wireless environmental sensor or monitoring device includes a processor unit, a monitor module for monitoring and collecting data corresponding to an environmental parameter, a radio module configured to enable wireless communication of the data to a remote system, and logic executable by the processor unit to: monitor wireless communication connectivity between the radio module and the remote system; and responsive to detecting a loss of wireless communication connectivity with the remote system, automatically enable a wireless access point (AP) mode of the radio module to initiate a broadcast of a local wireless network identifier to enable a client device to wirelessly locate and connect to the sensor device.", "According to another embodiment of the present disclosure, a method and technique for wireless connectivity monitoring and resolution for a wireless environmental monitoring or sensor device includes: monitoring and collecting, by an environmental sensor device, data corresponding to an environmental parameter; wirelessly communicating the data from the environmental sensor device to a remote system; monitoring, by the environmental sensor device, wireless communication connectivity with the remote system; and responsive to detecting a loss of wireless communication connectivity with the remote system, automatically enabling a wireless access point (AP) mode of a radio module of the environmental sensor device to initiate a broadcast of a local wireless network identifier to enable a client device to wirelessly locate and connect to the environmental sensor device.", "According to yet another embodiment of the present disclosure, a wireless environmental monitoring or sensor device includes a processor unit, a monitor module for monitoring and collecting data corresponding to an environmental parameter, a radio module configured to enable wireless communication of the data to a remote system, and logic executable by the processor unit to: determine a change from local power source to a remote power source for powering the sensor device; and responsive to detecting the change, switch the monitor module to a second operating parameter mode for monitoring the environmental parameter according to a second setting.", "BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS For a more complete understanding of the present application, the objects and advantages thereof, reference is now made to the following descriptions taken in conjunction with the accompanying drawings, in which: FIG.", "1 is an embodiment of a network of data processing systems in which the illustrative embodiments of the present disclosure may be implemented; FIG.", "2 is an embodiment of a data processing system in which the illustrative embodiments of the present disclosure may be implemented; FIG.", "3 is a diagram illustrating an embodiment of a wireless environmental sensor device in which illustrative embodiments of the present disclosure may be implemented; and FIG.", "4 is a flow diagram illustrating an embodiment of a method for wireless connectivity monitoring and resolution according to the present disclosure.", "DETAILED DESCRIPTION Embodiments of the present disclosure provide a wireless environmental monitoring or sensor device that monitors its wireless connection to a remote network and, if that connectivity is lost or otherwise becomes disconnected, the device automatically toggles to a mode where it functions as a wireless access point to enable another device to access its wireless configuration settings.", "Thus, the device can have its wireless connection to a remote system for data offload reestablished remotely without the need for manually changing the network configuration of the Wi-Fi radio of the device.", "Embodiments of the present disclosure also use the power mode as a proxy for where the sensor assembly may be and what it is monitoring.", "Depending on the power source, the device can automatically change it monitoring operating parameters.", "As will be appreciated by one skilled in the art, aspects of the present disclosure may be embodied as a system/device/apparatus, method or computer program product.", "Accordingly, aspects of the present disclosure may take the form of an entirely hardware embodiment, an entirely software embodiment (including firmware, resident software, micro-code, etc.)", "or an embodiment combining software and hardware aspects that may all generally be referred to herein as a “circuit,” “module” or “system.” Furthermore, aspects of the present disclosure may take the form of a computer program product embodied in one or more computer readable medium(s) having computer readable program code embodied thereon.", "Any combination of one or more computer usable or computer readable medium(s) may be utilized.", "The computer readable medium may be a computer readable signal medium or a computer readable storage medium.", "A computer readable storage medium may be, for example but not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any suitable combination of the foregoing.", "More specific examples may include a portable computer diskette, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or Flash memory), a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.", "In the context of this document, a computer readable storage medium may be any tangible medium that can contain, or store a program for use by or in connection with and instruction execution system, apparatus or device.", "A computer readable signal medium may include a propagated data signal with computer readable program code embodied therein, for example, in baseband or as part of a carrier wave.", "Such a propagated signal may take any of a variety of forms, including, but not limited to, electro-magnetic, optical, or any suitable combination thereof.", "A computer readable signal medium may be any computer readable medium that is not a computer readable storage medium and that can communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device.", "Program code embodied on a computer readable medium may be transmitted using any appropriate medium, including but not limited to wireless, wireline, optical fiber cable, RF, etc., or any suitable combination of the foregoing.", "The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server.", "In the latter scenario, the remote computer may be connected to the user's computer through any type of network, including a local area network (LAN) or a wide area network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet Service Provider).", "Aspects of the present disclosure as described below with reference to flowchart illustrations and/or block diagrams of methods, apparatus (systems) and computer program products according to embodiments of the disclosure.", "It will be understood that each block of the flowchart illustrations and/or block diagrams, and combinations of blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer program instructions.", "These computer program instructions may be provided to a processor of a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the functions/acts specified in the flowchart and/or block diagram block or blocks.", "These computer program instructions may also be stored in a computer-readable medium that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable medium produce an article of manufacture including instruction means which implement the function/act specified in the flowchart and/or block diagram block or blocks.", "The computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide processes for implementing the functions/acts specified in the flowchart and/or block diagram block or blocks.", "With reference now to the Figures and in particular with reference to FIGS.", "1-2, exemplary diagrams of data processing environments are provided in which illustrative embodiments of the present disclosure may be implemented.", "It should be appreciated that FIGS.", "1-2 are only exemplary and are not intended to assert or imply any limitation with regard to the environments in which different embodiments may be implemented.", "Many modifications to the depicted environments may be made.", "FIG.", "1 is a pictorial representation of a network of data processing systems in which illustrative embodiments of the present disclosure may be implemented.", "Network data processing system 100 is a network of computers in which the illustrative embodiments of the present disclosure may be implemented.", "Network data processing system 100 contains network 130, which is the medium used to provide communications links between various devices and computers connected together within network data processing system 100.Network 130 may include connections, such as wire, wireless communication links, or fiber optic cables.", "In some embodiments, server 140 and server 150 connect to network 130 along with data store 160.In addition, clients 110 and 120 connect to network 130.Clients 110 and 120 may be, for example, personal computers or network computers.", "In the depicted example, server 140 provides data and/or services such as, but not limited to, data files, operating system images, and applications to clients 110 and 120.Network data processing system 100 may include additional servers, clients, and other devices.", "In the depicted example, network data processing system 100 is the Internet with network 130 representing a worldwide collection of networks and gateways to communicate with one another.", "Network data processing system 100 also may be implemented as a number of different types of networks, such as for example, an intranet, a local area network (LAN), or a wide area network (WAN).", "FIG.", "1 is intended as an example, and not as an architectural limitation for the different illustrative embodiments.", "FIG.", "2 is an embodiment of a data processing system 200 such as, but not limited to, client 110 and/or server 140 in which an embodiment of an access authentication system according to the present disclosure may be implemented.", "In this embodiment, data processing system 200 includes a bus or communications fabric 202, which provides communications between processor unit 204, memory 206, persistent storage 208, communications unit 210, input/output (I/O) unit 212, and display 214.Processor unit 204 serves to execute instructions for software that may be loaded into memory 206.Processor unit 204 may be a set of one or more processors or may be a multi-processor core, depending on the particular implementation.", "Further, processor unit 204 may be implemented using one or more heterogeneous processor systems in which a main processor is present with secondary processors on a single chip.", "As another illustrative example, processor unit 204 may be a symmetric multi-processor system containing multiple processors of the same type.", "In some embodiments, memory 206 may be a random access memory or any other suitable volatile or non-volatile storage device.", "Persistent storage 208 may take various forms depending on the particular implementation.", "For example, persistent storage 208 may contain one or more components or devices.", "Persistent storage 208 may be a hard drive, a flash memory, a rewritable optical disk, a rewritable magnetic tape, or some combination of the above.", "The media used by persistent storage 208 also may be removable such as, but not limited to, a removable hard drive.", "Communications unit 210 provides for communications with other data processing systems or devices.", "In these examples, communications unit 210 is a network interface card.", "Modems, cable modem and Ethernet cards are just a few of the currently available types of network interface adapters.", "Communications unit 210 may provide communications through the use of either or both physical and wireless communications links.", "Input/output unit 212 enables input and output of data with other devices that may be connected to data processing system 200.In some embodiments, input/output unit 212 may provide a connection for user input through a keyboard and mouse.", "Further, input/output unit 212 may send output to a printer.", "Display 214 provides a mechanism to display information to a user.", "Instructions for the operating system and applications or programs are located on persistent storage 208.These instructions may be loaded into memory 206 for execution by processor unit 204.The processes of the different embodiments may be performed by processor unit 204 using computer implemented instructions, which may be located in a memory, such as memory 206.These instructions are referred to as program code, computer usable program code, or computer readable program code that may be read and executed by a processor in processor unit 204.The program code in the different embodiments may be embodied on different physical or tangible computer readable media, such as memory 206 or persistent storage 208.Program code 216 is located in a functional form on computer readable media 218 that is selectively removable and may be loaded onto or transferred to data processing system 200 for execution by processor unit 204.Program code 216 and computer readable media 218 form computer program product 220 in these examples.", "In one example, computer readable media 218 may be in a tangible form, such as, for example, an optical or magnetic disc that is inserted or placed into a drive or other device that is part of persistent storage 208 for transfer onto a storage device, such as a hard drive that is part of persistent storage 208.In a tangible form, computer readable media 218 also may take the form of a persistent storage, such as a hard drive, a thumb drive, or a flash memory that is connected to data processing system 200.The tangible form of computer readable media 218 is also referred to as computer recordable storage media.", "In some instances, computer readable media 218 may not be removable.", "Alternatively, program code 216 may be transferred to data processing system 200 from computer readable media 218 through a communications link to communications unit 210 and/or through a connection to input/output unit 212.The communications link and/or the connection may be physical or wireless in the illustrative examples.", "The different components illustrated for data processing system 200 are not meant to provide architectural limitations to the manner in which different embodiments may be implemented.", "The different illustrative embodiments may be implemented in a data processing system including components in addition to or in place of those illustrated for data processing system 200.Other components shown in FIG.", "2 can be varied from the illustrative examples shown.", "For example, a storage device in data processing system 200 is any hardware apparatus that may store data.", "Memory 206, persistent storage 208, and computer readable media 218 are examples of storage devices in a tangible form.", "FIG.", "3 is a diagram illustrating an embodiment of an environmental sensor device 300 in accordance with the present disclosure.", "Device 300 is configured to monitor one or more environmental parameters encountered or experienced by an object to which it is attached, mounted, or otherwise associated.", "For example, device 300 may comprise a shock sensor, temperature sensor, humidity sensor, chemical sensor, radiation sensor, or a combination thereof, or other type of sensor for monitoring a desired environmental parameter(s).", "In the embodiment illustrated in FIG.", "3, device 300 comprises a data processing system having a processor unit 314, a storage resource or memory 316, a transceiver 318, and a local or onboard power source 320.Device 300 also includes one or more environmental sensors 302 for detecting and/or monitoring various environmental parameters (e.g., shock sensor, temperature sensor, humidity sensor, etc.).", "Transceiver 318 may be used to facilitate wireless communications between device 300 and other systems/devices.", "Power source 320 may comprise a battery located on, within, and/or otherwise configured as part of device 300 for supplying power to various operational components of device 300.In the embodiment illustrated in FIG.", "3, memory 316 comprises a radio module 322, a monitor module 324, wireless configuration data 326, environmental data 328, and logic 330.In FIG.", "3, radio module 322, monitor module 324, and logic 330 are illustrated as a software program residing in memory 316 and executable by processor unit 314.However, it should be understood that radio module 322, monitor module 324, and/or logic 330 may comprise software, logic and/or executable code for performing various functions as described herein (e.g., residing as software and/or an algorithm running on a processor unit, hardware logic residing in a processor or other type of logic chip, centralized in a single integrated circuit or distributed among different chips in a data processing system).", "Radio module 322 performs various operations associated with wireless communications between device 300 and other devices and/systems.", "For example, in the embodiment illustrated in FIG.", "3, device 300 may communicate wirelessly with other remote data processing systems such as a server 340 and a client device 342.Wireless configuration data 326 may comprise various types of information and/or settings associated with radio module 322 and/or transceiver 318 for the wireless communications and/or connections of device 300.For example, wireless configuration data 326 may comprise information associated with connected and/or associated wireless networks that device 300 may be connected to (e.g., a wireless network 350 associated with server 340), authentication and/or encryption mechanisms, network name/identifiers, etc.", "Monitor module 324 performs various operations associated with the environmental parameter monitoring operations and processes performed by device 300.For example, monitor module 324 may be configured to cause device to monitor, store and/or analyze various environmental sensor input signals associated with sensor(s) 302.In the embodiment illustrated in FIG.", "3, monitor module includes operating parameter mode(s) 352.Mode(s) 352 may comprise one or more settings and/or operational characteristics for respectively different monitoring modes for device 300.For example, in some embodiments, one mode 352 may be used while device 300 is being powered by power source 320 while a different mode 352 may be used while being powered by an external power source 354.As an example, consider device 300 being configured to monitor for shock events.", "Device 300 may initially be configured to operate according to a first mode 354 that monitors for shock events at a particular shock frequency using a first set of screening or filtering parameters.", "This first mode 354 may be used while device 300 is attached to an object while that object is being transported to an intended destination.", "During this transportation, device 300 is powered by power source 320.The object to which device 300 is associated may then be installed in a particular application, and device 300 may be connected to power source 354 for a long-term monitoring application.", "The monitoring parameters for the installed application may differ from the monitoring parameters during transportation such that a different shock monitoring frequency may be applicable to the installation application as well as a different set of screening or filtering aspects.", "It should be understood that different modes 352 may also be used for other circumstances (e.g., other than being contingent on a power source), such as different operating parameters according to a user's particular application, different frequencies of data collection at different periods of time, etc.", "The information acquired or collected using sensor(s) 302 and monitor module 324 may be stored as environmental data 328.In the illustrated embodiment, radio module 322 includes a wireless client mode 360 and a wireless access point (AP) mode 362.In client mode 360, device 300 is wirelessly connected to a remote system, such as server 340, via network 350.For example, a user of device 300 may access and/or set configuration data 326 so as to wirelessly connect to and/or associate device 300 with network 350 to facilitate the wireless communication of data 328 to server 340 to enable access to and/or evaluation of data 328 via server 340.Thus, in client mode 360, server 340 functions as a wireless access point where device 300 connects to server 340's network 350 to report data 328 to server 340.In AP mode 362, device 300 is configured to function as a wireless access point such that radio module 322/transceiver 318 functions as a networking hardware device that allows a Wi-Fi compliant device (e.g., client device 342) to connect to device 300.For example, in AP mode 362, radio module 322 may cause a Service Set Identifier (SSID) to be broadcast identifying a wireless network provided by device 300.Thus, in AP mode 362, when a wireless device (e.g., client device 342) searches the area for wireless networks, client device 342 will detect the SSID of device 300 to enable client device 342 to associate with or wirelessly connect to device 300.Client device 342 may then access configuration data 326 (e.g., downloading and/or logging into an internal configuration web page of device 300 using a browser on client device 342) to set or modify wireless communication/network settings to enable device 300 to be wirelessly connected to network 350 or alter/set/modify other types of wireless configuration information.", "Logic 330 may be used to perform various monitoring functions and cause certain functions of device 300 to be invoked or ceased based on the monitored conditions.", "In the illustrated embodiment, logic 330 is depicted separate and apart from radio module 322 and monitor module 324; however, it should be understood that various functions, code, and/or circuitry associated with logic 330 may be incorporated in and/or be part of radio module 322 and/or monitor module 324 (and transceiver 318).", "In some embodiments, logic 330 is configured to monitor for wireless connectivity of device 300 with a remote system (e.g., server 340).", "For example, logic 330 may be configured to perform heartbeat monitoring or other types of packet or signal loss analysis techniques to determine whether a wireless connection as a client to another network (e.g., network 350 of server 340) has been lost or disconnected.", "In response to detecting a loss of wireless connectivity of device 300 as a client to another access point or wireless network (e.g., network 350 of server 340), logic 330 causes AP mode 362 to be automatically initiated for radio module 322 to enable device 300 to serve as an access point, thereby enabling the wireless connectivity issue to be evaluated and/or modified.", "For example, in some embodiments, logic 330 may be configured to monitor for lost wireless connectivity to network 350 and, after some threshold period of time of an indicated lost wireless connection to network 350, radio module 322 is automatically placed into AP mode 362 to enable client device 342 to wirelessly connect to device 300 and access configuration data 326.In this manner, client device 342 enables a user of device 300 to access configuration data 326 to correct any configuration settings to enable device 300 to re-connect to network 350, change configuration settings to enable device 300 to connect to a new/different remote wireless network for exporting data 328 thereto, or perform other wireless configuration functions.", "In some embodiments, in response to a completion or confirmation of changes to configuration data 326, logic 330 may automatically cause radio module 322 to switch to client mode 360 to reestablish a wireless connection as a client to network 350 (or another wireless network) for sharing/exporting data 328, thereby ceasing the providing of a wireless network as an access point and the cessation of any SSID broadcast.", "In some embodiments, in response to logic 330 detecting that device 300 has established a wireless connection to a remote network as a client (as opposed to functioning as an access point), logic 330 may cause radio module 322 to case the AP mode 362 and be automatically placed or returned to client mode 360, thereby ceasing the providing of a wireless network as an access point and the cessation of any SSID broadcast.", "Thus, in some embodiments, in normal operation, radio module 322 of device 300 operates as a client (e.g., client mode 360) where device 300 reports or exports data 328 to a software server or access point (e.g., server 340 via wireless network 350).", "However, if device 300 is located or used in an application where device 300 is difficult to access (e.g., the top drive of a drilling rig), a loss of wireless connectivity may be problematic (e.g., such as if the access point changes a network configuration, thereby causing the wireless connection of device 300 to a remote network for data 328 exportation to be lost).", "In this example, a user may have to attempt to reestablish a wireless connection by climbing up to the drilling rig and manually reconnecting device 300 to the access point (or another access point).", "Accordingly, embodiments of the present disclosure enable radio module 322 and/or logic 330 to output a status signal/message regarding its wireless connection to a Wi-Fi access point (e.g., server 340 via network 350).", "If the wireless connection is lost for some period of time (e.g., 30 minutes or more) logic 330 may cause radio module 322 to automatically toggle to AP mode 362.When device 300 is in AP mode 362, client device 342 remote from device 300 can connect to device 300 and log into the device 300's internal configuration webpage (e.g., by opening a browser and having the client device 342 navigate to a specific address associated with device 300), thereby enabling changes to be made to radio module 322 (e.g., configuration data 326) so radio module 322 can connect back to the Wi-Fi network that is collecting data 328 from device 300.Accordingly, this feature eliminates someone having to physically access device 300 to make any necessary wireless configuration setting changes.", "An example of a Wi-Fi radio that can operate in both client mode or host/AP mode is the ACKme Networks™ Radio # AMW006.In some embodiments, radio module 322 may be manually placed into AP mode 362 by a user physically depressing a button, switch or actuator 370.Logic 330 may be configured to monitor for a particular power mode as a proxy for where device 300 may be and what device 300 is monitoring.", "For example, in some embodiments, logic 330 is configured to detect whether device 300 is being powered from local power source 320 or remote power source 354.Depending on the mode for powering device 300, logic 330 may cause monitor module 324 to invoke different operating parameter modes 352 (e.g., the mode of powering device 300 being an indication of the particular operating parameters that device 300 should be operating under and/or the monitoring parameter criteria it should be using).", "In some embodiments, in response to logic 322 detecting that device 300 is being powered by remote power source 354, logic 322 may automatically cause monitor module 324 to switch from a first operating parameter mode 352 to a second operating parameter mode 352 where each has a different set or criteria of monitoring aspects.", "The reverse may also be configured for logic 330 (e.g., switching from a first mode 352 to a second mode 352 in response to detecting power from power source 320).", "As an example, consider that, initially, device 300 is operating under power from power source 320 (e.g., an onboard battery).", "Logic 330 is configured to cause monitor module 324 to initially operate according to a first operating parameter mode 352 where a certain sensing range, sampling rate, and/or filtering frequency is used when monitoring for a particular environmental parameter.", "In this initial operating phase, logic 330 may be configured such that this first mode 352 is used during a transportation phase of the object to which device 300 is associated.", "Upon the object reaching its final destination/installation, device 300 may be connected to external power source 354 (e.g., for a longer operational period).", "Logic 330 is configured to detect a change from power source 320 to power source 354 and, in response thereto, cause monitor module to switch to a second mode 352 where different sensing range, sampling rate, and/or filtering frequency is used when monitoring for a particular environmental parameter.", "For example, a single or particular device 300 may be used in different operating environments.", "If device 300 is a shock sensor, for example, device 300 might be placed on a top drive that is being transported to a well site to be placed on a wellhead.", "During the transportation of the top drive, the unit weighs a couple of orders of magnitude less (e.g.", "˜10,000 pounds) when compared to the top drive as an integral part of the wellhead itself (e.g.", "˜1,000,000 pounds).", "These differences in the structure or object to be monitored by device 300 require changes in how device 300 operates.", "For example it may be desirable to have different monitoring frequencies and different shock screening parameters for the different phases experienced by an object to which device 300 is associated.", "In the above example, when a shock sensor is attached to the top drive of a wellhead before the top drive is installed at the well site, the top drive may be transported via land and sea out to the rig.", "When the top drive is being transported to the well site, its dynamic profile is of an item that weighs about 10,000 pounds.", "For this scenario, specific G ranges and filter criteria are required to get the best recording of any impacts that it may encounter during transportation.", "However, when the top drive arrives at the rig and is installed, it becomes part of a much different dynamic profile.", "The top drive is now part of a 1,000,000+ pound environment where a different set of G-ranges and filters need to be used.", "Accordingly, the power source (e.g., either DC battery power or external AC power) can be used as proxy for the current status and/or location of device 300.For example, when device 300 on the top drive is operating in transit, device 300 would be using internal power source 320 (e.g., a DC battery).", "When device 300 begins using external power source 354 (e.g., AC power), it is presumed that device 300 is no longer in transit and, instead, is in a static environment after being installed on the wellhead.", "Thus, in some embodiments, logic 330 may be configured to detect changes between operation under DC or AC power and automatically change the operating parameters (e.g., G-ranges, filters and monitoring frequency) based upon this power source determination.", "FIG.", "4 is a flow diagram illustrating an embodiment of a method for wireless connectivity monitoring and resolution of a wireless environmental sensor device according to the present disclosure.", "The method begins at block 402, where an AP mode 362 of radio module 322 for device 300 is invoked.", "For example, in some embodiments, actuator 370 may be initially activated so as to enable client device 342 to access configuration data 326 to set initial wireless configuration settings.", "At block 404, device 300 receives setup information for configuration data 326 to enable device 300 to wirelessly connect as a client to a remote access point (e.g., network 350 of server 340) to enable the export of data 328 thereto.", "At block 406, radio module 322 is switched from AP mode 362 to client mode 360.At block 408, radio module 322 wirelessly connects to the remote system access point.", "At block 410, monitor module 320 monitors and collects environmental data 328 corresponding to environmental parameters set by one or more operating parameter modes 352.At block 412, logic 330 monitors for wireless connectivity of device 300 with the remote system access point (e.g., network 350 of server 340).", "At decisional block 414, logic 330 determines whether a loss of wireless connectivity has occurred relative to the remote access point (e.g., network 350 of server 340).", "If not, the method proceeds to block 412 where logic 330 continues to monitor the status of the wireless connectivity to the remote system access point.", "At decisional block 414, if a determination is made that there has been a loss of wireless connectivity to the remote access point (e.g., network 350 of server 340), the method proceeds to block 416 where logic 330 (immediately or after some threshold or predetermined time period of elapsed time of continued connectivity loss) causes radio module 322 to switch from client mode 360 to AP mode 362 (e.g., where device 300 performs as a wireless network access point and begins broadcasting its SSID information).", "At block 418, radio module 322 receives a wireless connection with client device 342 (e.g., via a user locating and connecting with the wireless network provided by device 300).", "At block 420, radio module 322 receives and stores any changes or modification to wireless configuration data 326 made by a user of client device 342.At block 422, upon the completion and/or confirmation of access/changes to wireless configuration data 422 by a user via client device 342, radio module 322 is automatically switched from AP mode 362 to client mode 360, thereby ceasing the use of device 300 as a wireless access point and the cessation of any broadcast of any SSID network information by device 300.At block 424, radio module 322 attempts to and/or connects with a remote wireless network access point as defined in the configuration data 326 settings (e.g., a new network for exporting data 328 and/or a re-connection with network 350).", "The method then proceeds to block 412 where logic 330 continues to monitor the connectivity status of device 300 to a remote system network for providing data 328 thereto.", "Thus, embodiments of the present disclosure enable a wireless environmental sensor device to monitor its wireless connection to a remote network and, if that connectivity is lost or otherwise becomes disconnected, the device automatically toggles to a mode where it functions as a wireless access point to enable another device to access its wireless configuration settings.", "Thus, the device can have its wireless connection to a remote system for data offload reestablished remotely without the need for manually changing the network configuration of the Wi-Fi radio of the device.", "Embodiments of the present disclosure also use the power mode as a proxy for where the sensor assembly may be and what it is monitoring.", "Depending on the power source, the device can automatically change it monitoring operating parameters.", "The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure.", "As used herein, the singular forms “a”, “an” and “the” are intended to include the plural forms as well, unless the context clearly indicates otherwise.", "It will be further understood that the terms “comprises” and/or “comprising,” when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.", "The corresponding structures, materials, acts, and equivalents of all means or step plus function elements in the claims below are intended to include any structure, material, or act for performing the function in combination with other claimed elements as specifically claimed.", "The description of the present disclosure has been presented for purposes of illustration and description, but is not intended to be exhaustive or limited to the disclosure in the form disclosed.", "Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the disclosure.", "The embodiment was chosen and described in order to best explain the principles of the disclosure and the practical application, and to enable others of ordinary skill in the art to understand the disclosure for various embodiments with various modifications as are suited to the particular use contemplated." ] ]
Patent_15875870
[ [ "METHODS AND SYSTEMS FOR INTRA BLOCK COPY CODING WITH BLOCK VECTOR DERIVATION", "Systems and methods are described for encoding and decoding video using derived block vectors as predictors in intra block copy mode.", "In an exemplary encoding method, an encoder identifies at least a first candidate block vector for the prediction of an input video block, where the first candidate block vector points to a first candidate block.", "The encoder then identifies a first predictive vector (e.g.", "a block vector or a motion vector) that was used to encode the first candidate block.", "From the first candidate block vector and the first predictive vector, the encoder generates a derived predictive vector from the first candidate block vector and the first predictive vector.", "The encoder then encodes the video block in the bit stream using the derived predictive vector for the prediction of the input video block." ], [ "1.A video codec operative to perform functions comprising: identifying a first candidate block vector for prediction of a video block, wherein the first candidate block vector points to a first candidate block; identifying at least a first predictive vector associated with the first candidate block; generating a derived predictive vector from the first candidate block vector and the first predictive vector; and coding the video block using the derived predictive vector.", "2.The video codec of claim 1, wherein coding the video block using the derived predictive vector includes: identifying a second candidate block that the derived predictive vector points to; and predicting the video block using the second candidate block.", "3.The video codec of claim 1, wherein coding the video block includes signaling the first candidate block vector in a bit stream.", "4.The video codec of claim 3, wherein the codec is further operative to perform the function of signaling the first predictive vector in the bit stream.", "5.The video codec of claim 3, wherein the codec is further operative to perform the function of signaling a flag in the bit stream, wherein a first value of the flag indicates that the derived predictive vector is used to code the video block.", "6.The video codec of claim 5, wherein a second value of the flag indicates that the first candidate block vector is used to code the video block.", "7.The video codec of claim 1, wherein the derived predictive vector is generated by adding the first candidate block vector and the first predictive vector.", "8.The video codec of claim 7, wherein the first candidate block vector and the first predictive vector have different precisions, and wherein adding the first block vector and the first predictive vector is performed after aligning them to the same precision.", "9.The video codec of claim 1, wherein the first predictive vector is a second block vector, and the derived predictive vector is a derived block vector.", "10.The video codec of claim 9, wherein the derived block vector is generated by adding the first candidate block vector and the second block vector.", "11.The video codec of claim 1, wherein the first predictive vector is a first motion vector, and the derived predictive vector is a derived motion vector.", "12.The video codec of claim 11, wherein the derived motion vector is generated by adding the first candidate block vector and the first motion vector.", "13.The video codec of claim 12, wherein the first candidate block vector and the first motion vector have different precisions, and wherein the derived motion vector is generated by aligning the precision of the first candidate block vector and the first motion vector and adding the precision aligned first candidate block vector and the precision aligned first motion vector.", "14.The video codec of claim 13, wherein the precision aligned first candidate block vector and the precision aligned first motion vector are added according to the equation MVd=BV0+((MV1+2)>>2), where BV0 is the first candidate block vector, MV1 is the first motion vector, and MVd is the derived motion vector.", "15.The video codec of claim 1, wherein the codec is further operative to perform the function of inserting the derived predictive vector into a merge candidate list.", "16.The video codec of claim 15, wherein the codec is further operative to perform the function of determining whether the derived predictive vector is valid, wherein the derived predictive vector is inserted into the merge candidate list only after determining that the derived predictive vector is valid.", "17.The video codec of claim 16, wherein determining whether the derived predictive vector is valid comprises: identifying a second candidate block that the derived predictive vector points to; determining whether all samples in the second candidate block are available; and determining that the derived predictive vector is valid if all samples in the second candidate block are available, and determining that the derived predictive vector is not valid if at least one sample in the second candidate block is not available.", "18.The video codec of claim 17, wherein a sample in the second candidate block is unavailable if any of the following is true: the sample is not yet coded, or the sample is in a different slice or in a different tile, or the sample is out of a video picture boundary 19.The video codec of claim 15, wherein coding the video block using the derived predictive vector includes providing an index identifying the derived predictive vector in the merge candidate list.", "20.A decoder operative to decode a coded video block from a bit stream encoding a video, the decoder being operative to perform functions comprising: identifying at least a first candidate block vector for prediction of the coded video block, wherein the first candidate block vector points to a first candidate block; identifying at least a first predictive vector associated with the first candidate block; generating a derived predictive vector from the first candidate block vector and the first predictive vector; and decoding the coded video block using the derived predictive vector.", "21.The video decoder of claim 20, wherein decoding the video block using the derived predictive vector includes: identifying a second candidate block that the derived predictive vector points to; and predicting the video block using the second candidate block.", "22.The video decoder of claim 20, wherein the decoder is further operative to decode information signaling the first candidate block vector from the bit stream.", "23.The video decoder of claim 22, wherein the decoder is further operative to decode a flag signaled in the bit stream, and wherein a first value of the flag indicates that the derived predictive vector is used to code the video block.", "24.The video decoder of claim 20, wherein the derived predictive vector is generated by adding the first candidate block vector and the first predictive vector.", "25.The video decoder of claim 20, wherein the decoder is further operative to perform the function of inserting the derived predictive vector into a merge candidate list.", "26.The video codec of claim 1, wherein the codec is a decoder." ], [ "<SOH> BACKGROUND <EOH>Over the past two decades, various digital video compression technologies have been developed and standardized to enable efficient digital video communication, distribution and consumption.", "Most of the commercially widely deployed standards are developed by ISO/IEC and ITU-T, such as H.261, MPEG-1, MPEG-2 H.263, MPEG-4 (part-2), and H.264/AVC (MPEG-4 part 10 Advance Video Coding).", "Due to the emergence and maturity of new advanced video compression technologies, a new video coding standard, High Efficiency Video Coding (HEVC), under joint development by ITU-T Video Coding Experts Group (VCEG) and ISO/IEC MPEG.", "HEVC (ITU-T H.265/ISO/IEC 23008-2) was approved as an international standard in early 2013, and is able to achieve substantially higher coding efficiency than the current state-of-the-art H.264/AVC.", "Screen content sharing applications have become more and more popular in recent years with the proliferation of remote desktop, video conferencing and mobile media presentation applications.", "A two-way screen content sharing system may include a host sub-system including a capturer, encoder and transmitter, and a client sub-system including a receiver, decoder and display (renderer).", "There are various application requirements from industries for screen content coding (SCC).", "As compared to natural video content, screen content often contains numerous blocks with several major colors and strong edges because of sharp curves and text that frequently appears in screen content.", "Although existing video compression methods can be used to encode screen content and then transmit that content to the receiver side, most existing methods does not accommodate the characteristics of screen content and thus lead to a low compression performance.", "The reconstruction of screen content using conventional video coding technologies often leads to serious quality issues.", "For example, the curves and texts are blurred and may be difficult to recognize.", "Therefore, a well-designed screen-content compression method is desirable for effectively reconstructing screen content." ], [ "<SOH> SUMMARY <EOH>In some exemplary embodiments, a method is provided for generating a bit stream encoding a video that includes an input video block.", "An encoder identifies at least a first candidate block vector (BV) for prediction of the input video block, where the first candidate block vector points to a first candidate block.", "The encoder then identifies a first predictive vector (e.g.", "a block vector or a motion vector) that was used to encode the first candidate block.", "From the first candidate block vector and the first predictive vector, the encoder generates a derived predictive vector (e.g.", "a derived block vector or a derived motion vector) from the first candidate block vector and the first predictive vector.", "The encoder then encodes the video block in the bit stream using the derived predictive vector for prediction of the input video block.", "In some embodiments, the encoder signals the derived predictive vector in the bit stream.", "In some embodiments, the encoder signals the first predictive vector in the bit stream and also signals a flag in the bit stream indicating that the input video block is encoded using the derived predictive vector that is derived from the first predictive vector.", "In some embodiment, the encoder signals in the bit stream an index identifying the derived predictive vector in a merge candidate list.", "The derived predictive vector may be generated by adding the first candidate block vector and the first predictive vector.", "In such embodiments, where the first predictive vector is a second block vector, the derived predictive vector may be a block vector generated by adding the first candidate block vector and the second block vector (the first predictive vector).", "If the first predictive vector is a motion vector, the derived predictive vector may be a motion vector generated by adding the first candidate block vector and the first motion vector according to the equation in-line-formulae description=\"In-line Formulae\" end=\"lead\"?", "MVd=BV 0+(( MV 1+2)>>2), in-line-formulae description=\"In-line Formulae\" end=\"tail\"?", "where BV 0 is the first candidate block vector, MV 1 is the first motion vector, and MVd is the derived motion vector.", "In some exemplary embodiments, derived predictive vectors (block vectors or motion vectors) are used as merge candidates.", "In an exemplary method, an encoder identifies at least a first block vector merge candidate for encoding of the input video block, and the encoder identifies a first predictive vector that was used to encode the first candidate block.", "The encoder then generates a derived predictive vector (a derived block vector or derived motion vector) from the first block vector merge candidate and the first predictive vector.", "The derived predictive vector is inserted in a merge candidate list.", "From the merge candidate list, the encoder chooses a selected predictive vector for the prediction of the input video block.", "The encoder then encodes the video input block in the bit stream using the selected predictive vector for the prediction of the input video block.", "The selected predictive vector may be the derived predictive vector.", "In some such embodiments, the encoder determines whether the merge candidate list is full before generating and inserting the derived predictive vector.", "The steps of generating and inserting the derived predictive vector in the merge candidate list are performed only after a determination is made that the merge candidate list is not full.", "In some such embodiments, the encoder identifies the first candidate block vector by conducting a search of previously-encoded video blocks.", "In an exemplary method of decoding a coded video block from a bit stream, a decoder identifies at least a first candidate block vector for the prediction of the input video block, wherein the first candidate block vector points to a first candidate block.", "The decoder identifies a first predictive vector used to encode the first candidate block.", "The decoder then generates a derived predictive vector from the first block vector and the first predictive vector and decodes the coded video block using the derived predictive vector for the prediction of the coded video block.", "In such embodiments, the first candidate block vector may be identified using various different techniques.", "In one such method, the first candidate block vector is signaled in the bit stream, and identification of the first candidate block vector includes receiving the first candidate block vector signaled in the bit stream.", "In such a method, the generation of the derived predictive vector may be performed in response to receiving a flag in the bit stream indicating that the input video block is encoded with a derived predictive vector.", "In another such method, the identification of a first candidate block vector includes identification of a first block vector merge candidate.", "In such an embodiment, the derived predictive vector may also be a merge candidate.", "The decoder may use the derived predictive vector to decode the coded video block in response to receiving an index in the bit stream identifying the derived predictive vector merge candidate." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS The present application is continuation of U.S. patent application Ser.", "No.", "14/743,657, filed Jun.", "18, 2015, which a non-provisional filing of, and claims benefit under 35 U.S.C.", "§ 119(e) from, U.S.", "Provisional Patent Application Ser.", "No.", "62/014,664, filed Jun.", "19, 2014.The contents of that application are incorporated herein by reference in its entirety.", "BACKGROUND Over the past two decades, various digital video compression technologies have been developed and standardized to enable efficient digital video communication, distribution and consumption.", "Most of the commercially widely deployed standards are developed by ISO/IEC and ITU-T, such as H.261, MPEG-1, MPEG-2 H.263, MPEG-4 (part-2), and H.264/AVC (MPEG-4 part 10 Advance Video Coding).", "Due to the emergence and maturity of new advanced video compression technologies, a new video coding standard, High Efficiency Video Coding (HEVC), under joint development by ITU-T Video Coding Experts Group (VCEG) and ISO/IEC MPEG.", "HEVC (ITU-T H.265/ISO/IEC 23008-2) was approved as an international standard in early 2013, and is able to achieve substantially higher coding efficiency than the current state-of-the-art H.264/AVC.", "Screen content sharing applications have become more and more popular in recent years with the proliferation of remote desktop, video conferencing and mobile media presentation applications.", "A two-way screen content sharing system may include a host sub-system including a capturer, encoder and transmitter, and a client sub-system including a receiver, decoder and display (renderer).", "There are various application requirements from industries for screen content coding (SCC).", "As compared to natural video content, screen content often contains numerous blocks with several major colors and strong edges because of sharp curves and text that frequently appears in screen content.", "Although existing video compression methods can be used to encode screen content and then transmit that content to the receiver side, most existing methods does not accommodate the characteristics of screen content and thus lead to a low compression performance.", "The reconstruction of screen content using conventional video coding technologies often leads to serious quality issues.", "For example, the curves and texts are blurred and may be difficult to recognize.", "Therefore, a well-designed screen-content compression method is desirable for effectively reconstructing screen content.", "SUMMARY In some exemplary embodiments, a method is provided for generating a bit stream encoding a video that includes an input video block.", "An encoder identifies at least a first candidate block vector (BV) for prediction of the input video block, where the first candidate block vector points to a first candidate block.", "The encoder then identifies a first predictive vector (e.g.", "a block vector or a motion vector) that was used to encode the first candidate block.", "From the first candidate block vector and the first predictive vector, the encoder generates a derived predictive vector (e.g.", "a derived block vector or a derived motion vector) from the first candidate block vector and the first predictive vector.", "The encoder then encodes the video block in the bit stream using the derived predictive vector for prediction of the input video block.", "In some embodiments, the encoder signals the derived predictive vector in the bit stream.", "In some embodiments, the encoder signals the first predictive vector in the bit stream and also signals a flag in the bit stream indicating that the input video block is encoded using the derived predictive vector that is derived from the first predictive vector.", "In some embodiment, the encoder signals in the bit stream an index identifying the derived predictive vector in a merge candidate list.", "The derived predictive vector may be generated by adding the first candidate block vector and the first predictive vector.", "In such embodiments, where the first predictive vector is a second block vector, the derived predictive vector may be a block vector generated by adding the first candidate block vector and the second block vector (the first predictive vector).", "If the first predictive vector is a motion vector, the derived predictive vector may be a motion vector generated by adding the first candidate block vector and the first motion vector according to the equation MVd=BV0+((MV1+2)>>2), where BV0 is the first candidate block vector, MV1 is the first motion vector, and MVd is the derived motion vector.", "In some exemplary embodiments, derived predictive vectors (block vectors or motion vectors) are used as merge candidates.", "In an exemplary method, an encoder identifies at least a first block vector merge candidate for encoding of the input video block, and the encoder identifies a first predictive vector that was used to encode the first candidate block.", "The encoder then generates a derived predictive vector (a derived block vector or derived motion vector) from the first block vector merge candidate and the first predictive vector.", "The derived predictive vector is inserted in a merge candidate list.", "From the merge candidate list, the encoder chooses a selected predictive vector for the prediction of the input video block.", "The encoder then encodes the video input block in the bit stream using the selected predictive vector for the prediction of the input video block.", "The selected predictive vector may be the derived predictive vector.", "In some such embodiments, the encoder determines whether the merge candidate list is full before generating and inserting the derived predictive vector.", "The steps of generating and inserting the derived predictive vector in the merge candidate list are performed only after a determination is made that the merge candidate list is not full.", "In some such embodiments, the encoder identifies the first candidate block vector by conducting a search of previously-encoded video blocks.", "In an exemplary method of decoding a coded video block from a bit stream, a decoder identifies at least a first candidate block vector for the prediction of the input video block, wherein the first candidate block vector points to a first candidate block.", "The decoder identifies a first predictive vector used to encode the first candidate block.", "The decoder then generates a derived predictive vector from the first block vector and the first predictive vector and decodes the coded video block using the derived predictive vector for the prediction of the coded video block.", "In such embodiments, the first candidate block vector may be identified using various different techniques.", "In one such method, the first candidate block vector is signaled in the bit stream, and identification of the first candidate block vector includes receiving the first candidate block vector signaled in the bit stream.", "In such a method, the generation of the derived predictive vector may be performed in response to receiving a flag in the bit stream indicating that the input video block is encoded with a derived predictive vector.", "In another such method, the identification of a first candidate block vector includes identification of a first block vector merge candidate.", "In such an embodiment, the derived predictive vector may also be a merge candidate.", "The decoder may use the derived predictive vector to decode the coded video block in response to receiving an index in the bit stream identifying the derived predictive vector merge candidate.", "BRIEF DESCRIPTION OF THE DRAWINGS A more detailed understanding may be had from the following description, presented by way of example in conjunction with the accompanying drawings, which are first briefly described below.", "FIG.", "1 is a block diagram illustrating an example of a block-based video encoder.", "FIG.", "2 is a block diagram illustrating an example of a block-based video decoder.", "FIG.", "3 is a diagram of an example of eight directional prediction modes.", "FIG.", "4 is a diagram illustrating an example of 33 directional prediction modes and two non-directional prediction modes.", "FIG.", "5 is a diagram of an example of horizontal prediction.", "FIG.", "6 is a diagram of an example of the planar mode.", "FIG.", "7 is a diagram illustrating an example of motion prediction.", "FIG.", "8 is a diagram illustrating an example of block-level movement within a picture.", "FIG.", "9 is a diagram illustrating an example of a coded bitstream structure.", "FIG.", "10 is a diagram illustrating an example communication system.", "FIG.", "11 is a diagram illustrating an example wireless transmit/receive unit (WTRU).", "FIG.", "12 is a diagram illustrating an example screen-content-sharing system.", "FIG.", "13 is a diagram illustrating an example of full frame intra block copy mode.", "FIG.", "14 is a diagram illustrating an example of local region intra block copy mode.", "FIG.", "15 is a diagram illustrating two examples of spatial candidates for intra block copy merge.", "FIG.", "16 is a diagram illustrating an example block vector derivation.", "FIG.", "17 is a diagram illustrating an example motion vector derivation.", "FIGS.", "18A and 18B together are a flowchart of an example method.", "DETAILED DESCRIPTION A detailed description of illustrative embodiments will now be provided with reference to the various Figures.", "Although this description provides detailed examples of possible implementations, it should be noted that the provided details are intended to be by way of example and in no way limit the scope of the application.", "FIG.", "1 is a block diagram illustrating an example of a block-based video encoder, for example, a hybrid video encoding system.", "The video encoder 100 may receive an input video signal 102.The input video signal 102 may be processed block by block.", "A video block may be of any size.", "For example, the video block unit may include 16×16 pixels.", "A video block unit of 16×16 pixels may be referred to as a macroblock (MB).", "In High Efficiency Video Coding (HEVC), extended block sizes (e.g., which may be referred to as a coding tree unit (CTU) or a coding unit (CU), two terms which are equivalent for purposes of this disclosure) may be used to efficiently compress high-resolution (e.g., 1080p and beyond) video signals.", "In HEVC, a CU may be up to 64×64 pixels.", "A CU may be partitioned into prediction units (PUs), for which separate prediction methods may be applied.", "For an input video block (e.g., an MB or a CU), spatial prediction 160 and/or temporal prediction 162 may be performed.", "Spatial prediction (e.g., “intra prediction”) may use pixels from already coded neighboring blocks in the same video picture/slice to predict the current video block.", "Spatial prediction may reduce spatial redundancy inherent in the video signal.", "Temporal prediction (e.g., “inter prediction” or “motion compensated prediction”) may use pixels from already coded video pictures (e.g., which may be referred to as “reference pictures”) to predict the current video block.", "Temporal prediction may reduce temporal redundancy inherent in the video signal.", "A temporal prediction signal for a video block may be signaled by one or more motion vectors, which may indicate the amount and/or the direction of motion between the current block and its prediction block in the reference picture.", "If multiple reference pictures are supported (e.g., as may be the case for H.264/AVC and/or HEVC), then for a video block, its reference picture index may be sent.", "The reference picture index may be used to identify from which reference picture in a reference picture store 164 the temporal prediction signal comes.", "The mode decision block 180 in the encoder may select a prediction mode, for example, after spatial and/or temporal prediction.", "The prediction block may be subtracted from the current video block at 116.The prediction residual may be transformed 104 and/or quantized 106.The quantized residual coefficients may be inverse quantized 110 and/or inverse transformed 112 to form the reconstructed residual, which may be added back to the prediction block 126 to form the reconstructed video block.", "In-loop filtering (e.g., a deblocking filter, a sample adaptive offset, an adaptive loop filter, and/or the like) may be applied 166 to the reconstructed video block before it is put in the reference picture store 164 and/or used to code future video blocks.", "The video encoder 100 may output an output video stream 120.To form the output video bitstream 120, a coding mode (e.g., inter prediction mode or intra prediction mode), prediction mode information, motion information, and/or quantized residual coefficients may be sent to the entropy coding unit 108 to be compressed and/or packed to form the bitstream.", "The reference picture store 164 may be referred to as a decoded picture buffer (DPB).", "FIG.", "2 is a block diagram illustrating an example of a block-based video decoder.", "The video decoder 200 may receive a video bitstream 202.The video bitstream 202 may be unpacked and/or entropy decoded at entropy decoding unit 208.The coding mode and/or prediction information used to encode the video bitstream may be sent to the spatial prediction unit 260 (e.g., if intra coded) and/or the temporal prediction unit 262 (e.g., if inter coded) to form a prediction block.", "If inter coded, the prediction information may comprise prediction block sizes, one or more motion vectors (e.g., which may indicate direction and amount of motion), and/or one or more reference indices (e.g., which may indicate from which reference picture to obtain the prediction signal).", "Motion-compensated prediction may be applied by temporal prediction unit 262 to form a temporal prediction block.", "The residual transform coefficients may be sent to an inverse quantization unit 210 and an inverse transform unit 212 to reconstruct the residual block.", "The prediction block and the residual block may be added together at 226.The reconstructed block may go through in-loop filtering 266 before it is stored in reference picture store 264.The reconstructed video in the reference picture store 264 may be used to drive a display device and/or used to predict future video blocks.", "The video decoder 200 may output a reconstructed video signal 220.The reference picture store 264 may also be referred to as a decoded picture buffer (DPB).", "A video encoder and/or decoder (e.g., video encoder 100 or video decoder 200) may perform spatial prediction (e.g., which may be referred to as intra prediction).", "Spatial prediction may be performed by predicting from already coded neighboring pixels following one of a plurality of prediction directions (e.g., which may be referred to as directional intra prediction).", "FIG.", "3 is a diagram of an example of eight directional prediction modes.", "The eight directional prediction modes of FIG.", "3 may be supported in H.264/AVC.", "As shown generally at 300 in FIG.", "3, the nine modes (including DC mode 2) are: Mode 0: Vertical Prediction Mode 1: Horizontal prediction Mode 2: DC prediction Mode 3: Diagonal down-left prediction Mode 4: Diagonal down-right prediction Mode 5: Vertical-right prediction Mode 6: Horizontal-down prediction Mode 7: Vertical-left prediction Mode 8: Horizontal-up prediction Spatial prediction may be performed on a video block of various sizes and/or shapes.", "Spatial prediction of a luma component of a video signal may be performed, for example, for block sizes of 4×4, 8×8, and 16×16 pixels (e.g., in H.264/AVC).", "Spatial prediction of a chroma component of a video signal may be performed, for example, for block size of 8×8 (e.g., in H.264/AVC).", "For a luma block of size 4×4 or 8×8, a total of nine prediction modes may be supported, for example, eight directional prediction modes and the DC mode (e.g., in H.264/AVC).", "Four prediction modes may be supported; horizontal, vertical, DC, and planar prediction, for example, for a luma block of size 16×16.Furthermore, directional intra prediction modes and non-directional prediction modes may be supported.", "FIG.", "4 is a diagram illustrating an example of 33 directional prediction modes and two non-directional prediction modes.", "The 33 directional prediction modes and two non-directional prediction modes, shown generally at 400 in FIG.", "4, may be supported by HEVC.", "Spatial prediction using larger block sizes may be supported.", "For example, spatial prediction may be performed on a block of any size, for example, of square block sizes of 4×4, 8×8, 16×16, 32×32, or 64×64.Directional intra prediction (e.g., in HEVC) may be performed with 1/32-pixel precision.", "Non-directional intra prediction modes may be supported (e.g., in H.264/AVC, HEVC, or the like), for example, in addition to directional intra prediction.", "Non-directional intra prediction modes may include the DC mode and/or the planar mode.", "For the DC mode, a prediction value may be obtained by averaging the available neighboring pixels and the prediction value may be applied to the entire block uniformly.", "For the planar mode, linear interpolation may be used to predict smooth regions with slow transitions.", "H.264/AVC may allow for use of the planar mode for 16×16 luma blocks and chroma blocks.", "An encoder (e.g., the encoder 100) may perform a mode decision (e.g., at block 180 in FIG.", "1) to determine the best coding mode for a video block.", "When the encoder determines to apply intra prediction (e.g., instead of inter prediction), the encoder may determine an optimal intra prediction mode from the set of available modes.", "The selected directional intra prediction mode may offer strong hints as to the direction of any texture, edge, and/or structure in the input video block.", "FIG.", "5 is a diagram of an example of horizontal prediction (e.g., for a 4×4 block), as shown generally at 500 in FIG.", "5.Already reconstructed pixels P0, P1, P2 and P3 (i.e., the shaded boxes) may be used to predict the pixels in the current 4×4 video block.", "In horizontal prediction, a reconstructed pixel, for example, pixels P0, P1, P2 and/or P3, may be propagated horizontally along the direction of a corresponding row to predict the 4×4 block.", "For example, prediction may be performed according to Equation (1) below, where L(x, y) may be the pixel to be predicted at (x, y) , x, y=0 .", ".", ".", "3 .", "L(x,0)=P0 L(x,1)=P1 L(x,2)=P2 L(x,3)=P3 (1) FIG.", "6 is a diagram of an example of the planar mode, as shown generally at 600 in FIG.", "6.The planar mode may be performed accordingly: the rightmost pixel in the top row (marked by a T) may be replicated to predict pixels in the rightmost column.", "The bottom pixel in the left column (marked by an L) may be replicated to predict pixels in the bottom row.", "Bilinear interpolation in the horizontal direction (as shown in the left block) may be performed to produce a first prediction H(x,y) of center pixels.", "Bilinear interpolation in the vertical direction (e.g., as shown in the right block) may be performed to produce a second prediction V(x,y) of center pixels.", "An averaging between the horizontal prediction and the vertical prediction may be performed to obtain a final prediction L(x,y), using L(x,y)=((H(x,y)+V(x,y))>>1).", "FIG.", "7 and FIG.", "8 are diagrams illustrating, as shown generally at 700 and 800, an example of motion prediction of video blocks (e.g., using temporal prediction unit 162 of FIG.", "1).", "FIG.", "8, which illustrates an example of block-level movement within a picture, is a diagram illustrating an example decoded picture buffer including, for example, reference pictures “Ref pic 0,” “Ref pic 1,” and “Ref pic2.” The blocks B0, B1, and B2 in a current picture may be predicted from blocks in reference pictures “Ref pic 0,” “Ref pic 1,” and “Ref pic2” respectively.", "Motion prediction may use video blocks from neighboring video frames to predict the current video block.", "Motion prediction may exploit temporal correlation and/or remove temporal redundancy inherent in the video signal.", "For example, in H.264/AVC and HEVC, temporal prediction may be performed on video blocks of various sizes (e.g., for the luma component, temporal prediction block sizes may vary from 16×16 to 4×4 in H.264/AVC, and from 64×64 to 4×4 in HEVC).", "With a motion vector of (mvx, mvy), temporal prediction may be performed as provided by equation (2): P(x, y)=ref(x−mvx, y−mvy) (2) where ref(x,y) may be pixel value at location (x, y) in the reference picture, and P(x,y) may be the predicted block.", "A video coding system may support inter-prediction with fractional pixel precision.", "When a motion vector (mvx, mvy) has fractional pixel value, one or more interpolation filters may be applied to obtain the pixel values at fractional pixel positions.", "Block-based video coding systems may use multi-hypothesis prediction to improve temporal prediction, for example, where a prediction signal may be formed by combining a number of prediction signals from different reference pictures.", "For example, H.264/AVC and/or HEVC may use bi-prediction that may combine two prediction signals.", "Bi-prediction may combine two prediction signals, each from a reference picture, to form a prediction, such as the following equation (3): P  ( x , y ) =  P 0  ( x , y ) + P 1  ( x , y ) 2 =  ref 0  ( x - mvx 0 , y - mvy 0 ) + ref 1  ( x - mvx 1 , y - mvy 1 ) 2 ( 3 ) where P0(x, y) and P1(x, y) may be the first and the second prediction block, respectively.", "As illustrated in equation (3), the two prediction blocks may be obtained by performing motion-compensated prediction from two reference pictures ref0(x, y) and ref1(x, y) , with two motion vectors (mvx0, mvy0) and (mvx1, mvy1), respectively.", "The prediction block P(x,y) may be subtracted from the source video block (e.g., at 116) to form a prediction residual block.", "The prediction residual block may be transformed (e.g., at transform unit 104) and/or quantized (e.g., at quantization unit 106).", "The quantized residual transform coefficient blocks may be sent to an entropy coding unit (e.g., entropy coding unit 108) to be entropy coded to reduce bit rate.", "The entropy coded residual coefficients may be packed to form part of an output video bitstream (e.g., bitstream 120).", "A single layer video encoder may take a single video sequence input and generate a single compressed bit stream transmitted to the single layer decoder.", "A video codec may be designed for digital video services (e.g., such as but not limited to sending TV signals over satellite, cable and terrestrial transmission channels).", "With video centric applications deployed in heterogeneous environments, multi-layer video coding technologies may be developed as an extension of the video coding standards to enable various applications.", "For example, multiple layer video coding technologies, such as scalable video coding and/or multi-view video coding, may be designed to handle more than one video layer where each layer may be decoded to reconstruct a video signal of a particular spatial resolution, temporal resolution, fidelity, and/or view.", "Although a single layer encoder and decoder are described with reference to FIG.", "1 and FIG.", "2, the concepts described herein may utilize a multiple layer encoder and/or decoder, for example, for multi-view and/or scalable coding technologies.", "Scalable video coding may improve the quality of experience for video applications running on devices with different capabilities over heterogeneous networks.", "Scalable video coding may encode the signal once at a highest representation (e.g., temporal resolution, spatial resolution, quality, etc.", "), but enable decoding from subsets of the video streams depending on the specific rate and representation required by certain applications running on a client device.", "Scalable video coding may save bandwidth and/or storage compared to non-scalable solutions.", "The international video standards, e.g., MPEG-2 Video, H.263, MPEG4 Visual, H.264, etc., may have tools and/or profiles that support modes of scalability.", "Table 1 provides an example of different types of scalabilities along with the corresponding standards that may support them.", "Bit-depth scalability and/or chroma format scalability may be tied to video formats (e.g., higher than 8-bit video, and chroma sampling formats higher than YUV4:2:0), for example, which may primarily be used by professional video applications.", "Aspect ratio scalability may be provided.", "TABLE 1 Scalability Example Standards View scalability 2D→3D (2 or more views) MVC, MFC, 3DV Spatial scalability 720p→1080p SVC, scalable HEVC Quality (SNR) 35 dB→38 dB SVC, scalable HEVC scalability Temporal scalability 30fps→60fps H.264/AVC, SVC, scalable HEVC Standards scalability H.264/AVC→HEVC 3DV, scalable HEVC Bit-depth scalability 8-bit video → 10-bit video Scalable HEVC Chroma format YUV4:2:0→YUV4:2:2, Scalable HEVC scalability YUV4:4:4 Color Gamut BT.709 → BT.2020 Scalable HEVC Scalability Aspect ratio 4:3→16:9 Scalable HEVC scalability Scalable video coding may provide a first level of video quality associated with a first set of video parameters using the base layer bitstream.", "Scalable video coding may provide one or more levels of higher quality associated with one or more sets of enhanced parameters using one or more enhancement layer bitstreams.", "The set of video parameters may include one or more of spatial resolution, frame rate, reconstructed video quality (e.g., in the form of SNR, PSNR, VQM, visual quality, etc.", "), 3D capability (e.g., with two or more views), luma and chroma bit depth, chroma format, and underlying single-layer coding standard.", "Different use cases may use different types of scalability, for example, as illustrated in Table 1.A scalable coding architecture may offer a common structure that may be configured to support one or more scalabilities (e.g., the scalabilities listed in Table 1).", "A scalable coding architecture may be flexible to support different scalabilities with minimum configuration efforts.", "A scalable coding architecture may include at least one preferred operating mode that may not require changes to block level operations, such that the coding logics (e.g., encoding and/or decoding logics) may be maximally reused within the scalable coding system.", "For example, a scalable coding architecture based on a picture level inter-layer processing and management unit may be provided, wherein the inter-layer prediction may be performed at the picture level.", "FIG.", "9 is a diagram illustrating an example of a coded bitstream structure.", "A coded bitstream 1000 consists of a number of NAL (Network Abstraction layer) units 1001.A NAL unit may contain coded sample data such as coded slice 1006, or high level syntax metadata such as parameter set data, slice header data 1005 or supplemental enhancement information data 1007 (which may be referred to as an SEI message).", "Parameter sets are high level syntax structures containing essential syntax elements that may apply to multiple bitstream layers (e.g.", "video parameter set 1002 (VPS)), or may apply to a coded video sequence within one layer (e.g.", "sequence parameter set 1003 (SPS)), or may apply to a number of coded pictures within one coded video sequence (e.g.", "picture parameter set 1004 (PPS)).", "The parameter sets can be either sent together with the coded pictures of the video bit stream, or sent through other means (including out-of-band transmission using reliable channels, hard coding, etc.).", "Slice header 1005 is also a high level syntax structure that may contain some picture-related information that is relatively small or relevant only for certain slice or picture types.", "SEI messages 1007 carry the information that may not be needed by the decoding process but can be used for various other purposes such as picture output timing or display as well as loss detection and concealment.", "FIG.", "10 is a diagram illustrating an example of a communication system.", "The communication system 1300 may comprise an encoder 1302, a communication network 1304, and a decoder 1306.The encoder 1302 may be in communication with the network 1304 via a connection 1308, which may be a wireline connection or a wireless connection.", "The encoder 1302 may be similar to the block-based video encoder of FIG.", "1.The encoder 1302 may include a single layer codec (e.g., FIG.", "1) or a multilayer codec.", "For example, the encoder 1302 may be a multi-layer (e.g., two-layer) scalable coding system with picture-level ILP support.", "The decoder 1306 may be in communication with the network 1304 via a connection 1310, which may be a wireline connection or a wireless connection.", "The decoder 1306 may be similar to the block-based video decoder of FIG.", "2.The decoder 1306 may include a single layer codec (e.g., FIG.", "2) or a multilayer codec.", "For example, the decoder 1306 may be a multi-layer (e.g., two-layer) scalable decoding system with picture-level ILP support.", "The encoder 1302 and/or the decoder 1306 may be incorporated into a wide variety of wired communication devices and/or wireless transmit/receive units (WTRUs), such as, but not limited to, digital televisions, wireless broadcast systems, a network element/terminal, servers, such as content or web servers (e.g., such as a Hypertext Transfer Protocol (HTTP) server), personal digital assistants (PDAs), laptop or desktop computers, tablet computers, digital cameras, digital recording devices, video gaming devices, video game consoles, cellular or satellite radio telephones, digital media players, and/or the like.", "The communications network 1304 may be a suitable type of communication network.", "For example, the communications network 1304 may be a multiple access system that provides content, such as voice, data, video, messaging, broadcast, etc., to multiple wireless users.", "The communications network 1304 may enable multiple wireless users to access such content through the sharing of system resources, including wireless bandwidth.", "For example, the communications network 1304 may employ one or more channel access methods, such as code division multiple access (CDMA), time division multiple access (TDMA), frequency division multiple access (FDMA), orthogonal FDMA (OFDMA), single-carrier FDMA (SC-FDMA), and/or the like.", "The communication network 1304 may include multiple connected communication networks.", "The communication network 1304 may include the Internet and/or one or more private commercial networks such as cellular networks, WiFi hotspots, Internet Service Provider (ISP) networks, and/or the like.", "FIG.", "11 is a system diagram of an example WTRU.", "As shown the example WTRU 1202 may include a processor 1218, a transceiver 1220, a transmit/receive element 1222, a speaker/microphone 1224, a keypad or keyboard 1226, a display/touchpad 1228, non-removable memory 1230, removable memory 1232, a power source 1234, a global positioning system (GPS) chipset 1236, and/or other peripherals 1238.It will be appreciated that the WTRU 1202 may include any sub-combination of the foregoing elements while remaining consistent with an embodiment.", "Further, a terminal in which an encoder (e.g., encoder 100) and/or a decoder (e.g., decoder 200) is incorporated may include some or all of the elements depicted in and described herein with reference to the WTRU 1202 of FIG.", "11.The processor 1218 may be a general purpose processor, a special purpose processor, a conventional processor, a digital signal processor (DSP), a graphics processing unit (GPU), a plurality of microprocessors, one or more microprocessors in association with a DSP core, a controller, a microcontroller, Application Specific Integrated Circuits (ASICs), Field Programmable Gate Array (FPGAs) circuits, any other type of integrated circuit (IC), a state machine, and the like.", "The processor 1218 may perform signal coding, data processing, power control, input/output processing, and/or any other functionality that enables the WTRU 1500 to operate in a wired and/or wireless environment.", "The processor 1218 may be coupled to the transceiver 1220, which may be coupled to the transmit/receive element 1222.While FIG.", "11 depicts the processor 1218 and the transceiver 1220 as separate components, it will be appreciated that the processor 1218 and the transceiver 1220 may be integrated together in an electronic package and/or chip.", "The transmit/receive element 1222 may be configured to transmit signals to, and/or receive signals from, another terminal over an air interface 1215.For example, in one or more embodiments, the transmit/receive element 1222 may be an antenna configured to transmit and/or receive RF signals.", "In one or more embodiments, the transmit/receive element 1222 may be an emitter/detector configured to transmit and/or receive IR, UV, or visible light signals, for example.", "In one or more embodiments, the transmit/receive element 1222 may be configured to transmit and/or receive both RF and light signals.", "It will be appreciated that the transmit/receive element 1222 may be configured to transmit and/or receive any combination of wireless signals.", "In addition, although the transmit/receive element 1222 is depicted in FIG.", "11 as a single element, the WTRU 1202 may include any number of transmit/receive elements 1222.More specifically, the WTRU 1202 may employ MIMO technology.", "Thus, in one embodiment, the WTRU 1202 may include two or more transmit/receive elements 1222 (e.g., multiple antennas) for transmitting and receiving wireless signals over the air interface 1215.The transceiver 1220 may be configured to modulate the signals that are to be transmitted by the transmit/receive element 1222 and/or to demodulate the signals that are received by the transmit/receive element 1222.As noted above, the WTRU 1202 may have multi-mode capabilities.", "Thus, the transceiver 1220 may include multiple transceivers for enabling the WTRU 1500 to communicate via multiple RATs, such as UTRA and IEEE 802.11, for example.", "The processor 1218 of the WTRU 1202 may be coupled to, and may receive user input data from, the speaker/microphone 1224, the keypad 1226, and/or the display/touchpad 1228 (e.g., a liquid crystal display (LCD) display unit or organic light-emitting diode (OLED) display unit).", "The processor 1218 may also output user data to the speaker/microphone 1224, the keypad 1226, and/or the display/touchpad 1228.In addition, the processor 1218 may access information from, and store data in, any type of suitable memory, such as the non-removable memory 1230 and/or the removable memory 1232.The non-removable memory 1230 may include random-access memory (RAM), read-only memory (ROM), a hard disk, or any other type of memory storage device.", "The removable memory 1232 may include a subscriber identity module (SIM) card, a memory stick, a secure digital (SD) memory card, and the like.", "In one or more embodiments, the processor 1218 may access information from, and store data in, memory that is not physically located on the WTRU 1202, such as on a server or a home computer (not shown).", "The processor 1218 may receive power from the power source 1234, and may be configured to distribute and/or control the power to the other components in the WTRU 1202.The power source 1234 may be any suitable device for powering the WTRU 1202.For example, the power source 1234 may include one or more dry cell batteries (e.g., nickel-cadmium (NiCd), nickel-zinc (NiZn), nickel metal hydride (NiMH), lithium-ion (Li-ion), etc.", "), solar cells, fuel cells, and the like.", "The processor 1218 may be coupled to the GPS chipset 1236, which may be configured to provide location information (e.g., longitude and latitude) regarding the current location of the WTRU 1202.In addition to, or in lieu of, the information from the GPS chipset 1236, the WTRU 1202 may receive location information over the air interface 1215 from a terminal (e.g., a base station) and/or determine its location based on the timing of the signals being received from two or more nearby base stations.", "It will be appreciated that the WTRU 1202 may acquire location information by way of any suitable location-determination method while remaining consistent with an embodiment.", "The processor 1218 may further be coupled to other peripherals 1238, which may include one or more software and/or hardware modules that provide additional features, functionality and/or wired or wireless connectivity.", "For example, the peripherals 1238 may include an accelerometer, orientation sensors, motion sensors, a proximity sensor, an e-compass, a satellite transceiver, a digital camera and/or video recorder (e.g., for photographs and/or video), a universal serial bus (USB) port, a vibration device, a television transceiver, a hands free headset, a Bluetooth® module, a frequency modulated (FM) radio unit, and software modules such as a digital music player, a media player, a video game player module, an Internet browser, and the like.", "By way of example, the WTRU 1202 may be configured to transmit and/or receive wireless signals and may include user equipment (UE), a mobile station, a fixed or mobile subscriber unit, a pager, a cellular telephone, a personal digital assistant (PDA), a smartphone, a laptop, a netbook, a tablet computer, a personal computer, a wireless sensor, consumer electronics, or any other terminal capable of receiving and processing compressed video communications.", "The WTRU 1202 and/or a communication network (e.g., communication network 804) may implement a radio technology such as Universal Mobile Telecommunications System (UMTS) Terrestrial Radio Access (UTRA), which may establish the air interface 1215 using wideband CDMA (WCDMA).", "WCDMA may include communication protocols such as High-Speed Packet Access (HSPA) and/or Evolved HSPA (HSPA+).", "HSPA may include High-Speed Downlink Packet Access (HSDPA) and/or High-Speed Uplink Packet Access (HSUPA).", "The WTRU 1202 and/or a communication network (e.g., communication network 804) may implement a radio technology such as Evolved UMTS Terrestrial Radio Access (E-UTRA), which may establish the air interface 1515 using Long Term Evolution (LTE) and/or LTE-Advanced (LTE-A).", "The WTRU 1202 and/or a communication network (e.g., communication network 804) may implement radio technologies such as IEEE 802.16 (e.g., Worldwide Interoperability for Microwave Access (WiMAX)), CDMA2000, CDMA2000 1X, CDMA2000 EV-DO, Interim Standard 2000 (IS-2000), Interim Standard 95 (IS-95), Interim Standard 856 (IS-856), Global System for Mobile communications (GSM), Enhanced Data rates for GSM Evolution (EDGE), GSM EDGE (GERAN), and the like.", "The WTRU 1500 and/or a communication network (e.g., communication network 804) may implement a radio technology such as IEEE 802.11, IEEE 802.15, or the like.", "FIG.", "12 is a diagram illustrating an example two-way screen-content-sharing system 1600.The diagram illustrates a host sub-system including capturer 1602, encoder 1604, and transmitter 1606.FIG.", "12 further illustrates a client sub-system including receiver 1608 (which outputs a received input bitstream 1610), decoder 1612, and display (renderer) 1618.The decoder 1612 outputs to display picture buffers 1614, which in turn transmits decoded pictures 1616 to the display 1618.There are application requirements from industries for screen content coding (SCC).", "See [R12], [R13].", "Screen content compression methods are becoming important for some specific applications because more and more people share their device content for media presentation or remote desktop purposes.", "The screen displays of mobile devices have greatly improved to support high definition or ultra-high definition resolutions.", "Traditional video coding methods increase the bandwidth requirement for transmitting screen content in screen-sharing applications.", "As discussed above, FIG.", "2 is a block diagram of a generic block-based single layer decoder that receives a video bitstream produced by an encoder such as the encoder in FIG.", "1, and reconstructs the video signal to be displayed.", "As also discussed above, at the video decoder, the bitstream is first parsed by the entropy decoder.", "The residual coefficients are inverse quantized and inverse transformed to obtain the reconstructed residual.", "The coding mode and prediction information are used to obtain the prediction signal using either spatial prediction or temporal prediction.", "The prediction signal and the reconstructed residual are added together to get the reconstructed video.", "The reconstructed video may additionally go through loop filtering before being stored in the reference picture store to be displayed and/or to be used to decode future video signals.", "As shown in FIG.", "1, to achieve efficient compression, a single layer encoder employs widely known techniques such as spatial prediction (also referred to as intra prediction) and temporal prediction (also referred to as inter prediction and/or motion compensated prediction) to predict the input video signal.", "The encoder also has mode decision logic that chooses the most suitable form of prediction, usually based on certain criteria such as a combination of rate and distortion considerations.", "See [R11].", "The encoder then transforms and quantizes the prediction residual (the difference signal between the input signal and the prediction signal).", "The quantized residual, together with the mode information (e.g., intra or inter prediction) and prediction information (motion vectors, reference picture indexes, intra prediction modes, etc.)", "are further compressed at the entropy coder and packed into the output video bitstream.", "As shown in FIG.", "1, the encoder also generates the reconstructed video signal by applying inverse quantization and inverse transform to the quantized residual to obtain a reconstructed residual, and adding it back to the prediction signal.", "The reconstructed video signal may additionally go through a loop filter process (for example, deblocking filter, Sample Adaptive Offsets, or Adaptive Loop Filters), and is finally stored in the reference picture store to be used to predict future video signal.", "In order to save transmission bandwidth and storage, MPEG has been working on video coding standards for many years.", "High Efficiency Video Coding (HEVC) (see [R13]) is an emerging video compression standard.", "HEVC is currently being jointly developed by ITU-T Video Coding Experts Group (VCEG) and ISO/IEC Moving Picture Experts Group (MPEG) together.", "It can save 50% bandwidth compared to H.264 with the same quality.", "HEVC is still a block-based hybrid video coding standard, in that its encoder and decoder generally operate according to the manner discussed above in connection with FIG.", "1 and FIG.", "2.HEVC allows the use of larger video blocks, and it uses quadtree partition to signal block coding information.", "The picture or slice is first partitioned into coding tree blocks (CTB) having the same size (e.g., 64×64).", "Each CTB is partitioned into CUs with quadtree, and each CU is partitioned further into prediction units (PU) and transform units (TU), also using quadtree.", "For each inter coded CU, its PU can be one of 8 partition modes, as shown and discussed above in connection with FIG.", "3.Temporal prediction, also called motion compensation, is applied to reconstruct all inter coded PUs.", "Depending on the precision of the motion vectors (which can be up to quarter pixel in HEVC), linear filters are applied to obtain pixel values at fractional positions.", "In HEVC, the interpolation filters have 7 or 8 taps for luma and 4 taps for chroma.", "The deblocking filter in HEVC is content based; different deblocking filter operations are applied at the TU and PU boundaries, depending on a number of factors, such as coding mode difference, motion difference, reference picture difference, pixel value difference, and so on.", "For entropy coding, HEVC adopts context-based adaptive arithmetic binary coding (CABAC) for most block level syntax elements except high level parameters.", "There are two kinds of bins in CABAC coding: one is context-based coded regular bins, and the other is by-pass coded bins without context.", "Although the current HEVC design contains various block coding modes, it does not fully utilize the spatial redundancy for screen content coding.", "This is because the HEVC is focused on continuous tone video content in 4:2:0 format, and the mode decision and transform coding tools are not optimized for the discrete tone screen content, which is often captured in the format of 4:4:4 video.", "As the HEVC standard began to mature and stabilize in late 2012, the standardization bodies VCEG and MPEG started to work on the future extension of HEVC for screen content coding.", "In January 2014, the Call for Proposals (CFP) of screen content coding was jointly issued by ITU-T VCEG and ISO/IEC MPEG.", "The CFP received a fair amount of attention, and resulted in seven responses [R2]-[R8] from various different companies proposing various efficient SCC solutions.", "Given that screen content material such as text and graphics show different characteristics compared to natural video content, some novel coding tools that improve the coding efficiency of screen content coding were proposed, for example, 1D string copy [R9], palette coding [R10], [R11] and intra block copy (IntraBC) [R12], [R17].", "All those screen content coding related tools were investigated in core experiments [R18]-[R22].", "Screen content has highly repetitive patterns in term of line segments or blocks and many small homogeneous regions (e.g.", "mono-color regions).", "Usually only a few colors exist within a small block.", "In contrast, there are many colors even in a small block for natural video.", "The color value at each position is usually repeated from its above or horizontal neighboring pixel.", "1D string copy involves predicting the string with variable length from previous reconstructed pixel buffers.", "The position and string length will be signaled.", "In palette coding mode, instead of directly coding the pixel value, a palette table is used as a dictionary to record those significant colors.", "And the corresponding palette index map is used to represent the color value of each pixel within the coding block.", "Furthermore, the “run” values are used to indicate the length of consecutive pixels that have the same significant colors (i.e., palette index), to reduce the spatial redundancy.", "Palette coding is usually good for large blocks containing sparse colors.", "An intra block copy involves using the reconstructed pixels to predict current coding blocks within the same picture, and the displacement information—which is referred to as block vector—is coded.", "FIG.", "13 is a diagram illustrating an example of full frame intra block copy mode.", "Considering the complexity and bandwidth access, in HEVC screen content coding extension reference software (SCM-1.0) [R31] has two configurations for intra block copy mode.", "One is full frame intra block copy mode, in which all reconstructed pixels can be used for prediction as shown generally at 1700 in FIG.", "13.In order to reduce the block vector searching complexity, hash based intra block copy search was proposed [R29], [R30].", "Another is local region intra block copy mode, which is discussed next.", "FIG.", "14 is a diagram illustrating an example of local region intra block copy mode, as shown generally at 1800.When local region intra block copy mode is used, only those reconstructed pixels in the left and current coding tree units (CTU) are allowed to be used as reference.", "There is another difference between SCC and natural video coding.", "For natural video coding, the coding distortion distributes in the whole picture.", "However, for screen content, the error is usually localized around strong edges, which makes the artifacts more visible even when the PSNR (peak signal to noise ratio) is quite high for whole picture.", "Therefore, screen content is more difficult to encode from subjective quality point of view.", "The use intra block copying mode requires signaling of the block vector.", "In full frame intra block copy configuration, the block vector can be very large, resulting in high overhead for intra block copy mode.", "Often, one block can find multiple similar matches because there is a highly repetitive pattern for screen content.", "In order to improve the block vector coding efficiency, various prediction and coding methods have been proposed [R23]-[R28].", "Embodiments of the presently disclosed systems and methods use block vector derivation to improve intra block copy coding efficiency.", "Among the variations discussed and described in this disclosure are (i) block vector derivation in intra block copy merge mode and (ii) block vector derivation in intra block copy with explicit block vector mode.", "Included in the present disclosure is discussion of a displacement information derivation method for intra block copy coding.", "Depending on the coding type of a reference block, a derived block vector or motion vector can be used in different ways.", "One method is to use the derived BV as a merge candidate in IntraBC merge mode; this option is discussed below in a subsection that is entitled “Intra Block Copy Merge Mode.” Another method is to use the derived BV/MV for normal IntraBC prediction; this option is discussed below in a subsection that is entitled “Intra Block Copy Mode with Derived Block Vector.” FIG.", "16 is a diagram illustrating an example block vector derivation.", "Given the block vector, the second block vector can be derived if the reference block pointed to by the given BV is an IntraBC coded block.", "The derived block vector is calculated in Eq.", "(4).", "FIG.", "16 shows this kind of block vector derivation generally at 2000.BVd=BV0+BV1 (4) FIG.", "17 is a diagram illustrating an example motion vector derivation.", "If the block pointed to by the given BV is an inter coded block, then the motion vector can be derived.", "FIG.", "17 shows the MV derivation case generally at 2100.If block B1 in FIG.", "17 is uni-prediction mode, then the derived motion MVd in integer pixel for block B0 is MVd=BV0+((MV1+2)>>2) (5) In some embodiments, the derived value MVd_q in quarter pixel resolution is calculated as MVd_q=(BV0<<2)+MV1 And the reference picture the same as that of B1.In HEVC, the normal motion vector is quarter pixel precision, and the block vector is integer precision.", "Integer pixel motion for derived motion vector is used by way of example here.", "If the block B1 is bi-prediction mode, then there are two ways to perform motion vector derivation.", "One is to derive two motion vectors for two directions separately and reference indices the same as uni-prediction mode.", "Another is to select the motion vector from the reference picture with a smaller quantization parameter (higher quality).", "If both reference pictures have the same quantization parameter, then we may select the motion vector from the closer reference picture in picture order of count (POC) distance (higher correlation).", "The following discussion uses the example of using the second way to convert bi-prediction to uni-prediction to reduce the complexity.", "Intra Block Copy Merge Mode.", "FIG.", "15 is a diagram illustrating two examples of spatial candidates for intra block copy merge.", "In HEVC main profile [R13] and range extension [R17], inter coding unit merge mode will not signal the motion information directly, but signal an index in the inter merge candidate list to the decoder.", "The inter merge candidate lists will be constructed in a deterministic way the same as that in the encoder.", "The motion information is derived from the candidate list using the index.", "In the example that is numbered 1902 in FIG.", "15, there are five spatial neighboring blocks and one temporal collocated block.", "Only those blocks coded in inter mode will be added in the inter merge candidate list.", "If the candidate list is not full with spatial and temporal neighboring blocks, then bi-prediction motion by combining existing merge candidates in two lists and zero motion will be appended.", "For intra block copy merge mode, a similar method of applying the merge mode is carried out.", "No BV information is coded explicitly, but a merge candidate index is coded.", "In the HEVC SCC extension (SCM-1.0) [R31], the BV is coded with differential coding using the last coded BV as its predictor.", "In BV candidate list construction, the BV predictor is checked first.", "If the BV predictor is valid for the current CU, then it is added as the first merge candidate.", "Then, in the examples numbered 1902 and 1904 in FIG.", "15, 5 spatial blocks are checked; those valid BVs are added in order if (1) the spatial neighboring block is IntraBC coded and therefore has a BV, (2) the BV is valid for the current CU (for example, the reference block pointed to by the BV is not out of picture boundary and is already coded), and (3) the BV has not appeared in the current candidate list already.", "If the merge candidate list is not full, then BVs are derived with those valid BVs already in the list.", "In one embodiment, only the derived block vector in equation (4) is considered, and the derived motion vector in equation (5) is not considered; in such examples, all of the merge candidates in the candidate list are block vectors that correspond to intra block copy modes.", "For complex design, the derived motion vector from equation (5) may be mixed together and added together with block vectors to the merge candidates.", "Another embodiment is for each candidate block vector BV0, if the BVd or MVd derived based on BV0 is valid, then we will consider the candidate block as bi-prediction mode with BV0 and BVd/MVd, where the bi-prediction is obtained by averaging a first prediction obtained by applying the block vector BV0, with a second prediction obtained by applying the derived block or motion vector BVd/MVd.", "FIGS.", "18A and 18B together are a flowchart of an example method of intra block copy merge candidate list construction.", "The example method 2200 begins at step 2202, which is “IntraBC merge candidate derivation.” The method next proceeds into the dashed box that is labeled “Spatial BV Candidates Generation,” and in particular to step 2204, which is “Add the BV predictor to merge candidate list if it is valid for current CU.” Processing next proceeds to step 2206, which is “Check the BV from spatial neighboring blocks, add it to merge candidate list if it is valid.” The method next proceeds to a decision box 2208, where the following condition is evaluated: “((left, top, top right, bottom left Neighboring blocks are checked)∥(num_of_cand_list>=max_num_of_merge_cand))?” If the condition at 2208 is determined to be false, processing returns to step 2206.If the condition at 2208 is instead determined to be true, processing proceeds to decision box 2210, at which the following condition is evaluated: “(num_of_cand_list<max_num_of_merge_cand−1)?” If the condition at 2210 is determined to be true, processing proceeds to step 2212, which is “Check the BV of top left neighboring block, add it to merge candidate list if it is valid.” If the condition at 2210 is determined to be false, step 2212 is bypassed.", "Either way, processing then proceeds to FIG.", "18B, into a dashed box entitled “BVd Candidates Generation,” and specifically to decision box 2216, at which the following condition is evaluated: “((all spatial BV candidates in the list checked)∥(num_of_cand_list>=max_num_of_merge_cand)?” If the condition at 2216 is determined to be true, the processing ends at 2224.If the condition at 2216 is determined to be false, processing proceeds to step 2218, which is “Take one spatial BV from candidate list, and derive BVd.” Next, processing proceeds to a decision box 2220, at which the following condition is evaluated: “BVd is valid?” If the condition at 2220 is determined to be true, processing proceeds to step 2222, which is “add BVd to merge candidate list.” If the condition at 2220 is instead determined to be false, then processing returns to the decision box 2216.Intra Block Copy Mode with Derived Block Vector.", "In normal intra block copy mode, the block vector will be signaled explicitly for each prediction unit within coding unit.", "In some embodiments, this mode is extended by adding a flag to indicate if the signaled block vector or the derived block vector is used in IntraBC prediction.", "If the flag is 0, then the signaled block vector is used for IntraBC prediction and no need to apply BV derivation.", "If the flag is 1, then the BV or MV is derived using equation (4) or equation (5) based on the signaled block vector, and the derived BV or MV will be used for intra block copy prediction or motion compensated prediction.", "Another embodiment is to add two flags to normal IntraBC mode.", "The first flag is used to indicate whether the BV derivation process is applied or not.", "If the first flag is 1, the second flag is coded to indicate whether uni-prediction or bi-prediction is used.", "If second flag is 0, then only the derived BV or MV is used for intra block copy prediction or motion compensated prediction.", "Otherwise, if the second flag is 1, the signaled BV is used to generate the first prediction, and the derived BV or MV is used to generate the second prediction; the final prediction is generated by averaging those two predictions, analogously to bi-prediction mode.", "Memory Access Bandwidth Reduction for Block Vector Derivation.", "Block vector derivation operates using information regarding the block coding mode and block vector/motion vector, such as the information of block B1 in FIG.", "16 and FIG.", "17.For decoder chip design, there are two ways to store the mode/BV/motion information of all coded blocks.", "One is to store the information in external memory.", "This technique requires access to external memory, thus increasing memory access bandwidth.", "Another technique is to cache the information in on-chip memory, which increases the cache size.", "Two exemplary methods are described here for reducing the amount of information required to be stored.", "One is to store that information with coarse granularity.", "In HEVC, the original BV/MV information is stored based on a 4×4 block size.", "The memory size will be greatly reduced by storing the original BV/MV information in compressed form based on larger block sizes, for example, in 16×16 block size.", "If 16×16 block size is used, the required BV storage has the same granularity as compressed motion in HEVC.", "In this way, it is possible to cache those data in a reasonable size.", "The second solution is to cache that information of coded blocks in a limited range instead of all blocks already coded.", "For example, the decoder may only cache the information pertaining to the current CTU row and a limited number of coded neighboring CTU rows above current CTU row.", "If the block B1 pointed by the first BV in FIG.", "16 and FIG.", "17 is outside the range that the decoder caches, then this BV will be regarded as invalid, and BV/MV derivation will not be applied.", "Coding Syntax and Semantics.", "New syntax elements were proposed to signal the CUs that are coded with intra block copy merge and intra block copy with derived block vector, based on the current syntax design of the HEVC range extension draft [R17].", "The proposed palette coding methods discussed in this section can be signaled in the bit-stream by introducing additional syntax.", "The following table (Table 2) shows the proposed syntax elements, changes to that of the HEVC range extension draft [R17] are contained in the lines numbered [10], [12], [13], [14], [17], [27], [28], [29], [40], [41], and [42].", "Syntax.", "TABLE 2 [01] coding_unit( x0, y0, log2CbSize ) { Descriptor [02] if( transquant_bypass_enabled_flag ) [03] cu_transquant_bypass_flag ae(v) [04] if( slice_type != I ) [05] cu_skip_flag[ x0 ][ y0 ] ae(v) [06] nCbS = ( 1 << log2CbSize ) [07] if( cu_skip_flag[ x0 ][ y0 ] ) [08] prediction_unit( x0, y0, nCbS, nCbS ) [09] else { [10] if( intra_block_copy_enabled_flag ) { [11] intra_bc_flag[ x0 ][ y0 ] ae(v) [12] if(intra_bc_flag[ x0 ][ y0 ]) [13] intra_bc_merge_flag[ x0 ][ y0 ] ae(v) [14] } [15] if( slice_type != I && !intra_bc_flag[ x0 ][ y0 ] ) [16] pred_mode_flag ae(v) [17] if( CuPredMode[ x0 ][ y0 ] != MODE_INTRA || (intra_bc_flag[ x0 ][ y0 ] && !intra_bc_merge_flag[ x0 ][ y0 ] ) || log2CbSize = = MinCbLog2SizeY ) [18] part_mode ae(v) [19] if( CuPredMode[ x0 ][ y0 ] = = MODE_INTRA ) { [20] if( PartMode = = PART_2N×2N && pcm_enabled_flag && !intra_bc_flag[ x0 ][ y0 ] && log2CbSize >= Log2MinIpcmCbSizeY && log2CbSize <= Log2MaxIpcmCbSizeY ) [21] pcm_flag[ x0 ][ y0 ] ae(v) [22] if( pcm_flag[ x0 ][ y0 ] ) { [23] while( !byte_aligned( ) ) [24] pcm_alignment_zero_bit f(1) [25] pcm_sample( x0, y0, log2CbSize ) [26] } else if( intra_bc_flag[ x0 ][ y0 ] ) { [27] if( intra_bc_merge_flag[ x0 ][ y0 ] ) [28] intra_bc_merge_index[ x0 ][ y0 ] ae(v) [29] if( !intra_bc_merge_flag[ x0 ][ y0 ] ) { [30] mvd_coding( x0, y0, 2) [31] if( PartMode = = PART_2N×N ) [32] mvd_coding( x0, y0 + ( nCbS / 2 ), 2) [33] else if( PartMode = = PART_N×2N ) [34] mvd_coding( x0 + ( nCbS / 2 ), y0, 2) [35] else if( PartMode = = PART_N×N ) { [36] mvd_coding( x0 + ( nCbS / 2 ), y0, 2) [37] mvd_coding( x0, y0 + ( nCbS / 2 ), 2) [38] mvd_coding( x0 + ( nCbS / 2 ), y0 + ( nCbS / 2 ), 2) [39] } [40] if( PartMode = = PART_2N×2N ) [41] intra_bc_bv_derivation_flag[ x0 ][ y0 ] ae(v) [42] } [43] } else { [44] pbOffset = ( PartMode = = PART_N×N ) ?", "( nCbS / 2 ) : nCbS [45] for( j = 0; j < nCbS; j = j + pbOffset ) [46] for( i = 0; i < nCbS; i = i + pbOffset ) [47] prev_intra_luma_pred_flag[ x0 + i ][ y0 + j ] ae(v) [48] for( j = 0; j < nCbS; j = j + pbOffset ) [49] for( i = 0; i < nCbS; i = i + pbOffset ) [50] if( prev_intra_luma_pred_flag[ x0 + i ][ y0 + j ] ) [51] mpm_idx[ x0 + i ][ y0 + j ] ae(v) [52] else [53] rem_intra_luma_pred_mode[ x0 + i ][ y0 + j ] ae(v) [54] if( ChromaArrayType = = 3 ) [55] for( j = 0; j < nCbS; j = j + pbOffset ) [56] for( i = 0; i < nCbS; i = i + pbOffset ) [57] intra_chroma_pred_mode[ x0 + i ][ y0 + j ] ae(v) [58] else if( ChromaArrayType != 0 ) [59] intra_chroma_pred_mode[ x0 ][ y0 ] ae(v) [60] } [61] } else { [62] if( PartMode = = PART_2N×2N ) [63] prediction_unit( x0, y0, nCbS, nCbS ) [64] else if( PartMode = = PART_2N×N ) { [65] prediction_unit( x0, y0, nCbS, nCbS / 2 ) [66] prediction_unit( x0, y0 + ( nCbS / 2 ), nCbS, nCbS / 2 ) [67] } else if( PartMode = = PART_N×2N ) { [68] prediction_unit( x0, y0, nCbS / 2, nCbS ) [69] prediction_unit( x0 + ( nCbS / 2 ), y0, nCbS / 2, nCbS ) [70] } else if( PartMode = = PART_2N×nU ) { [71] prediction_unit( x0, y0, nCbS, nCbS / 4 ) [72] prediction_unit( x0, y0 + ( nCbS / 4 ), nCbS, nCbS * 3 / 4 ) [73] } else if( PartMode = = PART_2N×nD ) { [74] prediction_unit( x0, y0, nCbS, nCbS * 3 / 4 ) [75] prediction_unit( x0, y0 + ( nCbS * 3 / 4 ), nCbS, nCbS / 4 ) [76] } else if( PartMode = = PART_nL×2N ) { [77] prediction_unit( x0, y0, nCbS / 4, nCbS ) [78] prediction_unit( x0 + ( nCbS / 4 ), y0, nCbS * 3 / 4, nCbS ) [79] } else if( PartMode = = PART_nR×2N ) { [80] prediction_unit( x0, y0, nCbS * 3 / 4, nCbS ) [81] prediction_unit( x0 + ( nCbS * 3 / 4 ), y0, nCbS / 4, nCbS ) [82] } else { /* PART_N×N */ [83] prediction_unit( x0, y0, nCbS / 2, nCbS / 2 ) [84] prediction_unit( x0 + ( nCbS / 2 ), y0, nCbS / 2, nCbS / 2 ) [85] prediction_unit( x0, y0 + ( nCbS / 2 ), nCbS / 2, nCbS / 2 ) [86] prediction_unit( x0 + ( nCbS / 2 ), y0 + ( nCbS / 2 ), nCbS / 2, nCbS / 2 ) [87] } [88] } [89] if( !pcm_flag[ x0 ][ y0 ] ) { [90] if( CuPredMode[ x0 ][ y0 ] != MODE_INTRA && !", "( PartMode = = PART_2N×2N && merge_flag[ x0 ][ y0 ] ) || ( CuPredMode[ x0 ][ y0 ] = = MODE_INTRA && intra_bc_flag[ x0 ][ y0 ] ) ) [91] rqt_root_cbf ae(v) [92] if( rqt_root_cbf ) { [93] MaxTrafoDepth = ( CuPredMode[ x0 ][ y0 ] = = MODE_INTRA ?", "( max_transform_hierarchy_depth_intra + IntraSplitFlag ) : max_transform_hierarchy_depth_inter ) [94] transform_tree( x0, y0, x0, y0, log2CbSize, 0, 0 ) [95] } [96] } [97] } [98] } With respect to Table 2, the following is noted: intra_bc_merge_flag[x0] [y0] equal to 1 specifies that the current coding unit is coded in merge mode, and the block vector is selected from the merge candidates.", "intra_bc_merge_flag[x0] [y0] equal to 0 specifies that the coding unit is not coded in merge mode, and the block vector of current coding unit is coded explicitly.", "When not present, the value of intra_bc_merge_flag is inferred to be equal to 0.The array indices x0, y0 specify the location (x0, y0) of the top-left luma sample of the considered coding block relative to the top-left luma sample of the picture.", "intra_bc_merge_index[x0] [y0] specifies the index among merge candidates that the block vector of current coding unit is the same as.", "intra_bc_merge_index[x0] [y0] shall be in the range of 0 to maximal number of intra block copying merge candidates minus 1.The array indices x0, y0 specify the location (x0, y0) of the top-left luma sample of the considered coding block relative to the top-left luma sample of the picture.", "intra_bc_bv_derivation_flag[x0] [y0] equal to 1 specifies that the derived BV or MV is used for current PU prediction.", "Further Exemplary Embodiments.", "In an exemplary embodiment, a derived block vector is generated, and the derived block vector is used as a merge candidate in an intra block-copy merge mode.", "In some such methods, the derived block vector, BVd, is determined according to BVd=BV0+BV1, given block vector BV0.In another exemplary embodiment, a derived motion vector is generated, and the derived motion vector is used as a merge candidate in an intra block-copy merge mode.", "In some such methods, the derived motion vector in integer pixel units, MVd, is determined according to MVd=BV0+((MV1+2)>>2), given block vector BV0.In an exemplary embodiment, a derived block vector is generated, and the derived block vector is used for normal IntraBC prediction with intra block copy method.", "In another exemplary embodiment, a derived motion vector is generated, and the derived motion vector is used for normal IntraBC prediction with motion compensation prediction method.", "In an exemplary embodiment, a block vector (BV) candidate list is formed.", "Derived BVs (BVds) are generated, and the BVds are added to the candidate list.", "In some such embodiments, the formation of the BV candidate list includes: adding the BV predictor if the BV predictor is valid for a current coding unit (CU), and checking five spatial blocks and adding those respective spatial block BVs that are valid.", "In some such embodiments, the spatial block BVs are added only if (i) the spatial neighboring block is IntraBC coded, (ii) the BV is valid for the current CU and (iii) the BV has not appeared in the current candidate list already.", "In some such embodiments, the BVds are generated only if the merge candidate list is not full.", "The BVds may be checked for validity prior to being added to the candidate list.", "In some embodiments, the BVds that are generated are only derived according to BVd=BV0+BV1.In some such methods, derived motion vectors (MVds) are generated, and the MVds are added to the candidate list.", "In some embodiments, the BVds are derived according to both (i) BVd=BV0+BV1 and (ii) MVd=BV0+((MV1+2)>>2).", "In some embodiments, a candidate block is treated as bi-prediction mode with BV0 and BVd/MVd.", "A bi-prediction may first be obtained by averaging a first prediction obtained by applying a block vector BV0, with a second prediction obtained by applying a block or motion vector BVd/MVd.", "In an exemplary embodiment, a video coded bitstream is received, and flag is identified in the bitstream indicating whether a signaled block vector or a derived block vector is used in IntraBC prediction.", "If the flag is a first value, then the signaled block vector is used for IntraBC prediction.", "If the flag is a second value then the BV or MV is derived based on the signaled block vector.", "In some such methods, the derived BV or MV is used for intra block copy prediction or motion compensated prediction.", "In another exemplary embodiment, a coded video bitstream is received.", "A first flag in the bitstream is identified as indicating whether a signaled block vector or a derived block vector is used in IntraBC prediction.", "A second flag in the bitstream is identified as indicating whether uni-prediction or bi-prediction is used.", "In some such embodiments, if the first flag is 1, and the second flag is 0, then only derived BV/MV is used for intra block copy prediction or motion compensated prediction.", "If the first flag is 1 and the second flag is 1, the signaled BV is used to generate the first prediction, and the derived BV/MV is used to generate the second prediction, and the final prediction is generated by averaging those two predictions.", "In an exemplary embodiment, original BV/MV information is compressed by storing the BV/MV information based on larger block sizes.", "The larger block size may be, for example, a 16×16 block size.", "In another exemplary embodiment, a decoder is used to cache information of coded blocks in a limited range that is less than all blocks already coded.", "In some such methods, the decoder only caches information of a current CTU row and a predetermined number of coded neighboring CTU rows above the current CTU row.", "In an exemplary embodiment, a video coding method of deriving predictive vector is provided.", "The method includes identifying a first candidate block vector for prediction of a video block, wherein the first candidate block vector points to a first candidate block.", "At least a first predictive vector associated with the first candidate block is identified.", "A derived predictive vector is generated from the first candidate block vector and the first predictive vector, and the video block is coded using the derived predictive vector.", "In some embodiments, the coding of the video block using the derived predictive vector includes identifying a second candidate block that the derived predictive vector points to and predicting the video block using the second candidate block.", "In some embodiments, coding the video block includes signaling the first candidate block vector in a bit stream.", "In some embodiments, coding the video block further includes signaling the first predictive vector in the bit stream.", "In some embodiments, coding the video block further includes signaling a flag in the bit stream, wherein a first value of the flag indicates that the derived predictive vector is used to code the video block and wherein a second value of the flag indicates that the first candidate block vector is used to code the video block.", "In some embodiments, encoding the input video block in the bit stream includes encoding in the bit stream an index identifying the derived predictive vector in a merge candidate list.", "The derived predictive vector is generated in some embodiments by adding the first candidate block vector and the first predictive vector.", "Where the first candidate block vector and the first predictive vector have different precisions, the adding of the first block vector and the first predictive vector may be performed after aligning them to the same precision.", "In some embodiments the video coding method further includes generating a merge candidate list and inserting the derived predictive vector into the merge candidate list.", "In some such embodiments, a determination is made of whether the derived predictive vector is valid, and the derived predictive vector is inserted into the merge candidate list only after determining that the derived predictive vector is valid.", "Coding the video block using the derived predictive vector includes providing an index identifying the derived predictive vector in the merge candidate list.", "The determination of whether the derived predictive vector is valid includes, in some embodiments, identifying a second candidate block that the derived predictive vector points to, determining whether all samples in the second candidate block are available.", "The derived predictive vector is determined to be valid if all samples in the second candidate block are available.", "The derived predictive vector is determined not to be valid if at least one sample in the second candidate block is not available.", "In some embodiments, a sample in the second candidate block is unavailable if any of the following is true: the sample is not yet coded, or the sample is in a different slice or in a different tile, or the sample is out of a video picture boundary.", "In an exemplary embodiment, a method is provided of decoding a coded video block from a bit stream encoding a video.", "At least a first candidate block vector is identified for prediction of the input video block, wherein the first candidate block vector points to a first candidate block.", "At least a first predictive vector associated with the first candidate block is identified.", "A derived predictive vector is generated from the first block vector and the first predictive vector, and the coded video block is decoded using the derived predictive vector.", "In some such embodiments, identification of a first candidate block vector includes receiving the first candidate block vector signaled in the bit stream.", "In some such embodiments, decoding of the coded video block using the derived predictive vector is performed in response to receiving a flag in the bit stream indicating that the input video block is encoded with a derived predictive vector.", "In some embodiments, identification of a first candidate block vector includes identification of a first block vector merge candidate.", "In some embodiments, the derived predictive vector is a derived predictive vector merge candidate, and decoding the coded video block using the derived predictive vector merge candidate is performed in response to receiving an index in the bit stream identifying the derived predictive vector merge candidate.", "In an exemplary embodiment, a video encoding method is provided for generating a bit stream encoding a video including an input video block.", "A neighboring block of the input video block is identified.", "The neighboring block may be, for example, the left, top, or top-left neighbor of the input video block.", "A first block vector associated with the neighboring block is identified, where the first block vector points to a first candidate block.", "A second block vector associated with the first candidate block is identified.", "A derived block vector is generated by adding the first block vector and the second block vector, and a first prediction block is generated for prediction of the input video block using the derived block vector.", "In some such embodiments, the encoding of the input video block further includes generating at least a second prediction block for prediction of the input video block using a third block vector.", "The first prediction block and the second prediction block are compared, and the prediction block and its associated block vector are selected based on an encoding metric.", "The encoding metric may be, for example, a Lagrangian rate-distortion cost.", "In an exemplary embodiment, a video encoder is provided for generating a bit stream to encode a video that includes an input video block.", "The encoder including a processor and a non-transitory storage medium storing instructions operative, when executed on the processor, to perform functions including: identifying at least a first candidate block vector for prediction of the input video block, wherein the first candidate block vector points to a first candidate block; identifying a first predictive vector used to encode the first candidate block; generating a derived predictive vector from the first candidate block vector and the first predictive vector; and encoding the input video block in the bit stream using the derived predictive vector for prediction of the input video block.", "In an exemplary embodiment, a video encoder is provided for generating a bit stream encoding a video including an input video block.", "The encoder includes a processor and a non-transitory storage medium storing instructions operative, when executed on the processor, to perform functions including: identifying at least a first block vector merge candidate for encoding of the input video block; identifying a first predictive vector used to encode the first candidate block; generating a derived predictive vector from the first block vector merge candidate and the first predictive vector; inserting the derived predictive vector in a merge candidate list; from the merge candidate list, choosing a selected predictive vector for prediction of the input video block; and encoding the input video block in the bit stream using the selected predictive vector for prediction of the input video block.", "In an exemplary embodiment, a video decoder is provided for decoding a coded video block from a bit stream encoding a video, the decoder including a processor and a non-transitory storage medium storing instructions operative, when executed on the processor, to perform functions including: identifying at least a first block vector for decoding of the coded video block; identifying a first predictive vector used to encode the first block vector; generating a derived predictive vector from the first block vector and the first predictive vector; and decoding the coded video block using the derived predictive vector for prediction of the coded video block.", "Although features and elements are described above in particular combinations, one of ordinary skill in the art will appreciate that each feature or element can be used alone or in any combination with the other features and elements.", "In addition, the methods described herein may be implemented in a computer program, software, or firmware incorporated in a computer-readable medium for execution by a computer or processor.", "Examples of computer-readable media include electronic signals (transmitted over wired or wireless connections) and computer-readable storage media.", "Examples of computer-readable storage media include, but are not limited to, a read only memory (ROM), a random access memory (RAM), a register, cache memory, semiconductor memory devices, magnetic media such as internal hard disks and removable disks, magneto-optical media, and optical media such as CD-ROM disks, and digital versatile disks (DVDs).", "A processor in association with software may be used to implement a radio frequency transceiver for use in a WTRU, UE, terminal, base station, RNC, or any host computer.", "REFERENCES [R1] ITU-T Q6/16 and ISO/IEC JCT1/SC29/WG11, “Joint Call for Proposals for Coding of Screen Content”, MPEG2014/N14175, January 2014, San Jose, USA.", "[R2] J. Chen, Y. Chen, T. Hsieh, R. Joshi, M. Karczewicz, W.-S. Kim, X. Li, C. Pang, W. Pu, K. Rapaka, J.", "Sole, L. Zhang, F. Zou, “Description of screen content coding technology proposal by Qualcomm”, JCTVC-Q0031, March 2014, Valencia, ES.", "[R3] C.-C. Chen, T.-S. Chang, R.-L. Liao, C.-W. Kuo, W.-H. Peng, H.-M.", "Hang, Y.-J.", "Chang, C.-H. Hung, C.-C. Lin, J.-S. Tu, E.-C. Ke, J.-Y.", "Kao, C.-L. Lin, F.-D. Jou, F.-C. Chen, “Description of screen content coding technology proposal by NCTU and ITRI International”, JCTVC-Q0032, March 2014, Valencia, ES.", "[R4] P. Lai, T.-D. Chuang, Y.-C. Sun, X. Xu, J. Ye, S.-T. Hsiang, Y.-W. Chen, K. Zhang, X. Zhang, S. Liu, Y.-W. Huang, S. Lei, “Description of screen content coding technology proposal by MediaTek”, JCTVC-Q0033, March 2014, Valencia, ES.", "[R5] Z. Ma, W. Wang, M. Xu, X. Wang, H. Yu, “Description of screen content coding technology proposal by Huawei Technologies”, JCTVC-Q0034, March 2014, Valencia, ES.", "[R6] B. Li, J. Xu, F. Wu, X. Guo, G. J. Sullivan, “Description of screen content coding technology proposal by Microsoft”, JCTVC-Q0035, March 2014, Valencia, ES.", "[R7] R. Cohen, A. Minezawa, X. Zhang, K. Miyazawa, A. Vetro, S. Sekiguchi, K. Sugimoto, T. Murakami, “Description of screen content coding technology proposal by Mitsubishi Electric Corporation”, JCTVC-Q0036, March 2014, Valencia, ES.", "[R8] X. Xiu, C.-M. Tsai, Y.", "He, Y. Ye, “Description of screen content coding technology proposal by InterDigital”, JCTVC-Q0037, March 2014, Valencia, ES.", "[R9] T. Lin, S. Wang, P. Zhang, and K. Zhou, “AHG8: P2M based dual-coder extension of HEVC”, Document no JCTVC-L0303, January 2013.", "[R10] X. Guo, B. Li, J.-Z.", "Xu, Y. Lu, S. Li, and F. Wu, “AHG8: Major-color-based screen content coding”, Document no JCTVC-00182, October 2013.", "[R11] L. Guo, M. Karczewicz, J.", "Sole, and R. Joshi, “Evaluation of Palette Mode Coding on HM-12.0+RExt-4.1”, JCTVC-00218, October 2013.", "[R12] C. Pang, J.", "Sole, L. Guo, M. Karczewicz, and R. Joshi, “Non-RCE3: Intra Motion Compensation with 2-D MVs”, JCTVC-N0256, July 2013.", "[R13] B. Bross, W-J.", "Han, G. J. Sullivan, J-R. Ohm, T. Wiegand, “High Efficiency Video Coding (HEVC) Text Specification Draft 10”, JCTVC-L1003.January 2013.", "[R14] G. J. Sullivan and T. Wiegand, Rate-distortion optimization for video compression.", "IEEE Signal Processing Magazine, vol.", "15, issue 6, November 1998.", "[R15] T. Vermeir, “Use cases and requirements for lossless and screen content coding”, JCTVC-M0172, April 2013, Incheon, KR.", "[R16] J.", "Sole, R. Joshi, M. Karczewicz, “AhG8: Requirements for wireless display applications”, JCTVC-M0315, April 2013, Incheon, KR.", "[R17] D. Flynn, M. Naccari, K. Sharman, C. Rosewarne, J.", "Sole, G. J. Sullivan, T. Suzuki, “HEVC Range Extension Draft 6”, JCTVC-P1005, January 2014, San Jose.", "[R18] J.", "Sole, S. Liu, “HEVC Screen Content Coding Core Experiment 1 (SCCE1): Intra Block Copying Extensions”, JCTVC-Q1121, March 2014, Valencia.", "[R19] C.-C. Chen, X. Xu, L. Zhang, “HEVC Screen Content Coding Core Experiment 2 (SCCE2): Line-based Intra Copy”, JCTVC-Q1122, March 2014, Valencia.", "[R20] Y.-W. Huang, P. Onno, R. Joshi, R. Cohen, X. Xiu, Z. Ma, “HEVC Screen Content Coding Core Experiment 3 (SCCE3): Palette mode”, JCTVC-Q1123, March 2014, Valencia.", "[R21] Y. Chen, J. Xu, “HEVC Screen Content Coding Core Experiment 4 (SCCE4): String matching for sample coding”, JCTVC-Q1124, March 2014, Valencia.", "[R22] X. Xiu, J. Chen, “HEVC Screen Content Coding Core Experiment 5 (SCCE5): Inter-component prediction and adaptive color transforms”, JCTVC-Q1125, March 2014, Valencia.", "[R23] P. Onno, G. Laroche, T. Poirier, C. Gisquet, “AhG5: On the displacement vector prediction scheme for Intra Block Copy”, JCTVC-Q0062, March 2014, Valencia.", "[R24] X. Zhang, K. Zhang, J.", "An, H. Huang, S. Lei, “Block vector prediction for intra block copy”, JCTVC-Q0080, March 2014, Valencia.", "[R25] K. Zhang, J.", "An, X. Zhang, H. Huang, S. Lei, “Symmetric intra block copy”, JCTVC-Q0082, March 2014, Valencia.", "[R26] S.-T. Hsiang, T.-D. Chuang, S. Lei, “AHG8; Coding the prediction differences of the intra BC vectors”, JCTVC-Q0095, March 2014, Valencia.", "[R27] C. Pang, J.", "Sole, R. Joshi, M. Karczewicz, “Block vector prediction method for intra block copy”, JCTVC-Q0114, March 2014, Valencia.", "[R28] L. Zhu, J. Xu, G. J. Sullivan, Y. Wu, S. Sankuratri, B.", "A. Kumar, “Ping-pong block vector predictor for intra block copy”, JCTVC-Q0134, March 2014, Valencia.", "[R29] B. Li, J. Xu, “Hash-based intraBC search”, JCTVC-Q0252, March 2014, Valencia.", "[R30] C. Pang, J.", "Sole, T. Hsieh, M. Karczewicz, “Intra block copy with larger search region”, JCTVC-Q0139, March 2014, Valencia.", "[R31] R. Joshi, J. Xu, R. Cohen, S. Liu, Z. Ma, Y. Ye, “Screen content coding test model 1 (SCM 1)”, JCTVC-Q1014, March 2014, Valencia." ] ]
Patent_15875885
[ [ "SEMICONDUCTOR LIGHT-EMITTING DEVICE", "A semiconductor light-emitting device includes a light-emitting member that includes a first semiconductor layer of a first conductivity type, a second semiconductor layer of a second conductivity type, and a light-emitting layer between the first semiconductor layer and the second semiconductor layer, a first metal layer electrically connected to the first semiconductor layer, and a second metal layer electrically connected to the second semiconductor layer.", "The light-emitting member has a first surface including a front surface of the first semiconductor layer, a second surface including a front surface of the second semiconductor layer, a side surface including an outer periphery of the first semiconductor layer, and a recess extending inwardly of the second surface to an interior portion of the first semiconductor layer to expose an inner surface on a side of the recess facing the side surface." ], [ "1.A semiconductor light-emitting device, comprising: a light-emitting member including a first semiconductor layer of a first conductivity type, a second semiconductor layer of a second conductivity type, and a light-emitting layer between the first semiconductor layer and the second semiconductor layer; a first metal layer electrically connected to the first semiconductor layer; and a second metal layer electrically connected to the second semiconductor layer, wherein the light-emitting member includes: a first surface including a front surface of the first semiconductor layer, a second surface including a front surface of the second semiconductor layer, a side surface including an outer periphery of the first semiconductor layer, and a recess extending inwardly of the second surface to an interior portion of the first semiconductor layer and exposing an inner surface on a side of the recess facing the side surface." ], [ "<SOH> BACKGROUND <EOH>A semiconductor light-emitting device includes, for example, a light-emitting member in which a p-type semiconductor layer, a light-emitting layer, and an n-type semiconductor layer are stacked.", "Light emitted from the light-emitting member has high luminance in the layer stack direction.", "For this reason, it is necessary to improve luminance in a direction crossing the layer stack direction for uses of light-emitting devices requiring wide light dispersion.", "For example, when a wavelength of light emitted from the light-emitting layer is converted using one or more phosphors, it is necessary to improve luminous efficiency as a whole by exciting the phosphors arranged near the sides of the light-emitting member in addition to the phosphors located in the stack direction." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "15/055,255, filed on Feb. 26, 2016, which is based upon and claims the benefit of priority from Japanese Patent Application No.", "2015-120275, filed Jun.", "15, 2015, the entire contents of each of which are incorporated herein by reference.", "FIELD Embodiments described herein relate generally to a semiconductor light-emitting device.", "BACKGROUND A semiconductor light-emitting device includes, for example, a light-emitting member in which a p-type semiconductor layer, a light-emitting layer, and an n-type semiconductor layer are stacked.", "Light emitted from the light-emitting member has high luminance in the layer stack direction.", "For this reason, it is necessary to improve luminance in a direction crossing the layer stack direction for uses of light-emitting devices requiring wide light dispersion.", "For example, when a wavelength of light emitted from the light-emitting layer is converted using one or more phosphors, it is necessary to improve luminous efficiency as a whole by exciting the phosphors arranged near the sides of the light-emitting member in addition to the phosphors located in the stack direction.", "DESCRIPTION OF THE DRAWINGS FIG.", "1A is a schematic top view showing a semiconductor light-emitting device according to a first embodiment, and FIG.", "1B is a schematic sectional view of the semiconductor light-emitting device.", "FIG.", "2A is another schematic top view showing the semiconductor light-emitting device according to the first embodiment, and FIGS.", "2B and 2C are schematic sectional views of a part of the semiconductor light-emitting device.", "FIGS.", "3A to 3C are schematic sectional views of an example of a light propagation path within a light-emitting member.", "FIGS.", "4A to 4C are schematic sectional views that depict steps in the method of manufacturing the semiconductor light-emitting device according to the first embodiment.", "FIGS.", "5A to 5C are schematic sectional views that depict additional steps in the method of manufacturing the semiconductor light-emitting device subsequent to the step depicted in FIG.", "4C.", "FIGS.", "6A and 6B are schematic sectional views that depict additional steps in the method of manufacturing the semiconductor light-emitting device subsequent to the step depicted in FIG.", "5C.", "FIGS.", "7A and 7B are schematic sectional views that depict additional steps in the method of manufacturing the semiconductor light-emitting device subsequent to the step depicted in FIG.", "6B.", "FIGS.", "8A and 8B are schematic sectional views that depict additional steps in the method of manufacturing the semiconductor light-emitting device subsequent to the step depicted in FIG.", "7B.", "FIG.", "9A is a schematic top view showing a semiconductor light-emitting device according to a second embodiment, and FIGS.", "9B and 9C are schematic sectional views of a major part of the semiconductor light-emitting device.", "FIG.", "10A is a schematic top view showing a semiconductor light-emitting device according to a third embodiment, and FIG.", "10B is a schematic sectional view of a major part of the semiconductor light-emitting device.", "FIGS.", "11A and 11B are schematic sectional views showing semiconductor light-emitting devices according to modification examples of the third embodiment.", "DETAILED DESCRIPTION Embodiments provide a semiconductor light-emitting device in which light dispersion is increased.", "In general, according to one embodiment, there is provided a semiconductor light-emitting device including a light-emitting member that includes a first semiconductor layer of a first conductivity type, a second semiconductor layer of a second conductivity type, and a light-emitting layer between the first semiconductor layer and the second semiconductor layer, a first metal layer electrically connected to the first semiconductor layer, and a second metal layer electrically connected to the second semiconductor layer.", "The light-emitting member has a first surface including a front surface of the first semiconductor layer, a second surface including a front surface of the second semiconductor layer, a side surface including an outer periphery of the first semiconductor layer, and a recess extending inwardly of the second surface to an interior portion of the first semiconductor layer to expose an inner surface on a side of the recess facing the side surface.", "Hereinafter, example embodiments will be described with reference to the drawings.", "The same elements depicted in different drawings will be assigned the same reference numerals and the repeated detailed description of these elements may be omitted when appropriate, such that differences in elements or other aspects can be described.", "The drawings are schematic and conceptual, and the depicted relationships between the thickness and width of elements and the ratios of sizes between elements are not necessarily the same as the actual values thereof.", "Even in a case where the same elements are shown, the dimensions or ratios thereof may be differently shown in the different drawings.", "The semiconductor light-emitting devices described in the following embodiments are merely an exemplary, and the scope of the present disclosure is not limited thereto.", "Furthermore, when the technical features described in the respective semiconductor light-emitting devices are technically applicable, the technical features thereof maybe applied in the respective embodiments in common.", "First Embodiment FIG.", "1A is a schematic top view showing a semiconductor light-emitting device 1 according to a first embodiment.", "FIG.", "1B is a schematic sectional view of the semiconductor light-emitting device 1 taken along line A-A shown in FIG.", "1A.", "The semiconductor light-emitting device 1 is a chip-shaped light source, and is mounted on, for example, a mounting substrate.", "As shown in FIG.", "1A, the semiconductor light-emitting device 1 includes a light-emitting member 10, and a substrate 20.The light-emitting member 10 is provided on the substrate 20.The semiconductor light-emitting device 1 includes bonding pads 31 arranged adjacent to, and partially surrounded by, the light-emitting member 10 on the substrate 20.As shown in FIG.", "1B which is a schematic sectional view of FIG.", "1A taken along line A-A, the light-emitting member 10 is attached to the substrate 20 by a bonding layer 25 interposed therebetween.", "The light-emitting member 10 includes a first semiconductor layer of a first conductivity type (hereinafter, referred to as an n-type semiconductor layer 11 having an n-doped conductivity type), a second semiconductor layer of a second conductivity type (hereinafter, referred to as a p-type semiconductor layer 12 having a p-doped conductivity type), and a light-emitting layer 15 interposed therebetween.", "The light-emitting member 10 has a structure in which the n-type semiconductor layer 11, the light-emitting layer 15, and the p-type semiconductor layer 12 are sequentially stacked one over the other.", "Although it will be described in the following description that the first conductivity type is the n-type and the second conductivity type is the p-type, embodiments of the present disclosure are not limited thereto.", "Exemplary embodiments also include cases where the first conductivity type is the p-type and the second conductivity type is the n-type.", "The light-emitting member 10 includes a first surface 10a which includes a front surface of the n-type semiconductor layer 11 which faces away from the bonding layer 25, a second surface 10b which includes a front surface of the p-type semiconductor layer 12 facing the bonding layer 25, and side surfaces 10c which include the outer periphery of the n-type semiconductor layer 11.The light-emitting member 10 includes a recess 50 formed in, and extending inwardly of, the second surface 10b.", "The recess 50 is formed to a depth from the second surface 10b to extend to the interior portion of the n-type semiconductor layer 11, e.g., a middle portion located approximately half way between first surface 10a and second surface 10b.", "The recess 50 includes a portion including inner surfaces 50a and 50b, and a portion including two inner surfaces 50b.", "The inner surface 50a is on the side of the recess 50 that faces the side surface 10c, and extends generally in the direction of, for example, the side surface 10c.", "Here, the side surface 10c and the inner surface 50a are shown as parallel to each other but they are not required to be parallel in other embodiments.", "For example, the recess 50 surrounds the p-type semiconductor layer 12 to divide it into a first portion 12a and a second portion 12b as shown in FIG.", "2A.", "The inner surface 50a includes an end surface of the first portion 12a, and the inner surface 50b includes an end surface of the second portion 12b.", "Light emitted from the light-emitting layer 15 is primarily irradiated to the outside of the light-emitting member 10 through the first surface 10a.", "The first surface 10a has a light extraction structure.", "The light extraction structure controls the total reflection of the emitted light, and improves light extraction efficiency.", "For example, the first surface 10a is provided with fine protrusions, and is roughened.", "The semiconductor light-emitting device 1 includes first metal layers (hereinafter, referred to as n electrodes 33), second metal layers (hereinafter, referred to as p electrodes 35), and third metal layers (hereinafter, referred to as metal layers 37 and 39) disposed on the second surface 10b of the light-emitting member 10.The n electrode 33 is electrically connected to the n-type semiconductor layer 11 at the base of the recess 50 extending inwardly thereof.", "The p electrode 35 is formed on the second portion 12b of the p-type semiconductor layer 12, and is electrically connected to the p-type semiconductor layer 12.The p electrode 35 is not formed on the first portion 12a of the p-type semiconductor layer 12.The metal layer 37 is formed on the p electrode 35.Preferably, the n electrodes 33, the p electrodes 35 and the metal layers 37 and 39 include a material having a high reflectance to the light emitted by the light-emitting layer 15.The n electrodes 33 include, for example, aluminum (Al).", "The p electrodes 35 and the metal layers 37 and 39 include, for example, silver (Ag).", "The metal layers 37 and 39 may not be formed.", "The semiconductor light-emitting device 1 includes dielectric films 41, 45 and 47.The dielectric film 41 covers a portion of the inner surface of the recesses 50 where the n electrodes 33 are not formed.", "The dielectric film 41 covers an outer periphery of the light-emitting layer 15 to protect the outer periphery of the light-emitting layer.", "The dielectric film 45 covers the entire region of the recesses 50 except the inwardly extending end thereof in contact with n-type semiconductor layer 11.The dielectric film 45 covers the sides and portion of the n electrodes 33 extending from the n-type semiconductor layer, and electrically insulates the n electrodes 33 from the substrate 20 and the bonding layer 25.The dielectric film 45 may be made of the same material as the dielectric film 41.The dielectric film 47 covers the first surface 10a and the side surfaces 10c of the light-emitting member 10.For example, the dielectric film 47 covers the light-emitting layer exposed to the side surfaces 10c to protect the light-emitting layer.", "The dielectric film 47 improves adhesion between the light-emitting member 10 and a resin which maybe disposed thereover.", "That is, it is effective in a case where a resin including phosphors is provided on the semiconductor light-emitting device 1.The metal layer 37 extends on the dielectric film 45, and covers the dielectric films 41 and 45 between the n electrode 33 and the p electrode 35.The metal layer 39 is formed on the dielectric film 45, and covers at least one of the inner surface 50a of the recess 50 and a portion of the second surface 10b between the side surface 10c and the inner surface 50a.", "The metal layer 37 reflects light which passes through the dielectric films 41 and 45 and propagates toward the substrate 20 and returns the light toward the first surface 10a between the n electrode 33 and the p electrode 35.The metal layer 39 reflects the light which passes through the dielectric films 41 and 45 and propagates toward the substrate 20 and returns the light toward the first surface 10a or the side surface 10c in the outer periphery of the light-emitting member 10.A gap is present between the adjacent ends of the metal layers 37, 39 on dielectric film 45.The bonding layer 25 is formed so as to cover the metal layers 37 and 39 and portions of the dielectric film 45 not covered by the metal layers 37, 39.The bonding layer 25 is, for example, a conductive layer including a bonding metal made of solder such as gold-tin (AuSn) or nickel-tin (NiSn).", "The p electrode 35 is electrically connected to the bonding layer 25 by the metal layer 37 interposed therebetween.", "The bonding layer 25 is electrically connected to the electrically conductive substrate 20 by contact with the substrate 20.The bonding layer 25 includes a high-melting-point metal film such as titanium (Ti), titanium-tungsten (TiW) between the p electrode 35, the metal layers 37 and 39 and the bonding metal.", "The high-melting-point metal film functions as a barrier film that prevents the solder from spreading to the p electrode 35 and the metal layers 37 and 39.An electrode 27 is formed on a rear surface of the substrate 20.The electrode 27 is, for example, a stacked film of Ti, Pt and Au layers, and has, for example, a film thickness of 800 nm.", "For example, the electrode 27 is connected to an external circuit with the mounting substrate interposed therebetween.", "In some embodiments, the mounting substrate may be a conductive material or comprise a conductive material.", "By contrast, the n electrodes 33 are connected to the external circuit through metal wires, such as gold or aluminum, which are connected to the bonding pads 31.FIG.", "2A is another schematic top view showing the semiconductor light-emitting device 1.FIG.", "2B is a schematic diagram showing a section taken along line B-B shown in FIG.", "2A.", "FIG.", "2C is a schematic diagram showing a section taken along line C-C shown in FIG.", "2A.", "FIG.", "2A is a schematic diagram showing a chip surface on the bottom of the light-emitting member 10.A broken line shown in the drawing indicates the outer periphery (an end of the side surface 10c) of the light-emitting member 10.The n electrode 33 is formed between the inner surfaces 50a and 50b of the recess 50 and between the inner surfaces 50b of the recess 50.The n electrode 33 includes portions (extension portions 33p) that extend to adjacent the side of the light-emitting member 10, and the bonding pads 31 are formed on the extension portions 33p.", "The p electrode 35 is formed on the second portion 12b of the p-type semiconductor layer 12 and is surrounded by the inner surfaces 50b (see FIG.", "1B).", "As shown in FIG.", "2A, the semiconductor light-emitting device 1 includes five p electrodes 35.The five p electrodes 35 are respectively formed in regions surrounded by the inner surfaces 50b.", "The portions of the light-emitting member 10 surrounded by the inner surfaces 50b include portions of the light-emitting layer 15, respectively.", "For example, a drive current of the semiconductor light-emitting device 1 is supplied from the electrode 27 on the rear surface of the substrate 20.The drive current thereof flows from the p electrode 35 to the n electrode 33 with the light-emitting layer 15 interposed therebetween.", "Accordingly, the semiconductor light-emitting device 1 radiates light from the five portions of the light-emitting layer 15 (emissive regions) surrounded by the inner surfaces 50b.", "As shown in FIG.2A, the inner surface 50a is formed so as to surround the five light-emitting regions.", "In FIG.", "2A, widths WG1, WG2 and WG3 of the recess 50 are shown.", "The recess 50 has the width WG1 extending from the emissive region toward an outer periphery in a portion which surrounds the largest emissive regions.", "The recess 50 has the width WG2 extending from the emissive region toward an outer periphery in a portion where the bonding pads 31 are formed.", "The n electrode 33 is formed in these portions.", "For example, the widths WG1 and WG2 are set based on the desired maximum value of the drive current and the size of the bonding pad.", "Meanwhile, the recess 50 has the width WG3 extending from the emissive region toward an outer periphery in a portion where the n electrode 33 is not formed.", "For example, the width WG3 is set in consideration with processing precision or a processing margin in a semiconductor process.", "The width WG3 is preferably set to be narrower in order to widen the area of the emissive region.", "A wide p electrode 35 can be formed in a wide emissive region.", "Thus, the current density of the light-emitting layer 15 is decreased due to the wide p electrode 35, and thus, internal quantum efficiency thereof is improved.", "More of the light emitted by the light-emitting layer 15 is reflected, and thus, it is possible to improve the light extraction efficiency of the device.", "Preferably, a minimum width of the recess 50 is in a range of, for example, 0.1 times to 10 times the thickness of the light-emitting member 10 in a stacked direction.", "More preferably, the minimum width of the recess 50 is in a range of 0.5 times to 2 times of the thickness of the light-emitting member 10 in the stacked direction.", "As shown in FIG.", "2B, the recess 50 formed in the outer periphery of the light-emitting member 10 divides the p-type semiconductor layer 12 into the first portion 12a and the second portion 12b.", "The p electrode 35 is formed on the second portion 12b, and is electrically connected to the second portion 12b.", "The p electrode 35 is not formed on the first portion 12a.", "That is, the first portion 12a is electrically isolated from the second portion 12b by the recess 50.Accordingly, drive current does not flow to the first portion 12a, and the light-emitting layer 15 in the first portion 12a does not radiate light.", "Similarly to the second portion 12b, the p electrode 35 may be formed on the first portion 12a.", "In this case, it is necessary for the dielectric film 47 to passivate the light-emitting layer 15 exposed to the side surface 10c.", "The inner surface 50a of the recess 50 is on the side of the recess 50 that faces the side surface 10c of the light-emitting member 10.An internal angle 0 of the inner surface 50a measured between the inner surface 50a and the second surface 10b of the light-emitting member 10 is preferably 90 degrees or more.", "As shown in FIG.", "2C, the extension portions 33p of the n electrode 33 extend toward a chip end 1e on the bonding layer 25 with the dielectric film 45 interposed therebetween.", "The light-emitting member 10 is not formed on the extension portion 33p, and the bonding pad 31 is formed on the extension portion 33p.", "FIGS.", "3A to 3C are schematic sectional views of the device showing an example of a propagation path of light that propagates through the inside of the light-emitting member 10.FIGS.", "3A and 3B show a section (the end portion of FIG.", "1B) of the light-emitting member 10 according to the embodiment.", "FIG.", "3C shows a section of a light-emitting member 110 according to a comparative example.", "As shown in FIG.", "3A, a portion of the light emitted from the light-emitting layer 15 propagates through the inside of the light-emitting member 10 toward the side surface 10c.", "For example, when the refractive index of the light-emitting member 10 is greater than the refractive index of the dielectric film 47, light LA1 is reflected from the side surface 10c, and propagates toward the inner surface 50a of the recess 50.When the refractive index of the light-emitting member 10 is greater than the refractive index of the dielectric film 41, the light LA1 is reflected from the inner surface 50a, and again propagates toward the side surface 10c.", "As stated above, when light reflection is repeated between the side surface 10c and the inner surface 50a, when the light LA1 incident on the side surface 10c is at an angle smaller than a critical angle of the total reflection, it passes through the side surface 10c, and is emitted to the outside.", "In the example shown in FIG.", "3B, the metal layer 39 is formed between the bonding layer 25 and the dielectric film 45.The metal layer 39 covers at least a portion of the second surface 10b with the dielectric film 45 interposed therebetween, and the inner surface 50a.", "For example, a portion of the light reflected from the side surface 10c passes through the inner surface 50a, and propagates toward the bonding layer 25.Light travelling along the path LA2 is reflected from the metal layer 39, and again propagates toward the side surface 10c.", "As mentioned above, when light is repeatedly reflected between the side surface 10c and the inner surface 50a or between the side surface 10c and the metal layer 39, when that light LA2 is incident on the side surface 10c at an angle smaller than a critical angle, it passes through the side surface 10c and is emitted to the outside of the light-emitting device 1.As the dielectric film 45 becomes thinner, the light LA2 which propagates through the inside of the dielectric film 45 and arrives at the bonding layer 25 is more and more reduced, and thus, it is possible to improve the light extraction efficiency of the device 1.As the dielectric film 45 becomes thicker, the insulation properties between the n electrode 33 and the bonding layer 25 become better, and thus, it is possible to improve reliability.", "Preferably, a thickness of the dielectric film 45 is in a range of, for example, 0.1 μm to 3 μm.", "More preferably, the thickness of the dielectric film is in a range of 0.5 μm to 2 μm.", "Unlike these examples, the light-emitting member 110 shown in FIG.", "3C does not have the recess 50 in the outer periphery thereof.", "Light LA3 which propagates through the inside of the light-emitting member 110 toward a side surface 110c is reflected from the side surface 110c, and propagates toward the second surface 110b.", "The light LA3 which propagates toward the second surface 110b is reflected from the second surface 110b, and propagates toward the first surface 110a.", "Thereafter, the light LA3 is repeatedly reflected in the light-emitting member 110, and is emitted to the outside of the light-emitting member 110 when the light is incident on the first surface 110a at an angle smaller than a critical angle.", "For example, when the first surface 110a has the light extraction structure, the total reflection on the first surface 110a is controlled, and the light LA3 is emitted to the outside without being repeatedly reflected within the light-emitting member 110.As discussed above, the recess 50 formed in the light-emitting member 10 increases the light radiation from the side surface 10c.", "Thus, since it is possible to widen the area of light dispersion of the semiconductor light-emitting device 1, it is possible to reduce light concentration toward the first surface 10a from the light-emitting layer 15, and it is possible to improve light dispersion characteristics of the device 1.In FIGS.", "3A and 3B, the side surface 10c of the light-emitting member 10 is inclined such that the second surface 10b extends closer to the periphery of the light-emitting device 1 than does first surface 10a.", "Such a side surface 10c is a surface that is easily formed when the semiconductor layers 11, 12 and light-emitting layer 15 are selectively etched.", "Most dielectric films used for manufacturing a semiconductor have a refractive index smaller a refractive index of the semiconductor.", "That is, advantageous effects of the recess 50 formed in the outer periphery of the light-emitting member 10 can be realized in many semiconductor light-emitting devices.", "Preferably, a gap WP between the inner surface 50a and the side surface 10c at second surface 10b extending from the emissive region toward the chip end 1e is in a range of, for example, 0.2 times to 10 times of the thickness of the light-emitting member 10 in the stacked direction.", "More preferably, the gap Wp is in a range of 0.5 times to 2 times of the thickness of the light-emitting member 10 in the stacked direction.", "For example, it is preferable that the gap Wp is set in the aforementioned range due to the limitations such as a method of processing the side surface 10c and the recess 50 or a design of light dispersion characteristics.", "Thus, most light which propagates toward the side surface 10c can be reflected from the inner surface 50a, and can be emitted from the side surface 10c.", "Next, a method of manufacturing the semiconductor light-emitting device 1 will be described with reference to FIGS.", "4A to 8B.", "FIGS.", "4A to 8B are schematic sectional views which sequentially show the results of manufacturing steps during the manufacturing of the semiconductor light-emitting device 1.As shown in FIG.", "4A, the n-type semiconductor layer 11, the light-emitting layer 15 and the p-type semiconductor layer 12 are sequentially formed and thus stacked on the substrate 101.In the present specifications, the stacked state includes a state in which another element or layer is interposed between the layers in addition to a state in which the layers are directly in contact with each other.", "A substrate 101 includes, for example, aluminum or silicon.", "The n-type semiconductor layer 11, the p-type semiconductor layer 12 and the light-emitting layer 15 include nitride semiconductors, respectively.", "The n-type semiconductor layer 11, the p-type semiconductor layer 12 and the light-emitting layer 15 include, for example, AlxGa1-x-yInyN (x≥0, y≥0, x+y≤1).", "The n-type semiconductor layer 11 includes, for example, a Si-doped n-type GaN contact layer, and a Si-doped n-type AlGaN cladding layer.", "The Si-doped n-type AlGaN cladding layer is arranged between the Si-doped n-type GaN contact layer and the light-emitting layer 15.The n-type semiconductor layer 11 may further include a buffer layer, and the Si-doped n-type GaN contact layer is arranged between the GaN buffer layer and the Si-doped n-type AlGaN cladding layer.", "For example, any one of AlN, AlGaN, and GaN or a combination thereof is used as the buffer layer.", "For example, the light-emitting layer 15 has a multiple quantum well (MQW) structure.", "For example, a plurality of barrier layers and a plurality of well layers are alternately stacked in the MQW structure.", "For example, AlGaInN is used as the well layer.", "For example, GaInN is used as the well layer.", "For example, Si-doped n-type AlGaN is used as the barrier layer.", "For example, Si-doped n-type Al0.1Ga0.9N is used as the barrier layer.", "For example, a thickness of the barrier layer is in a range of 2 nm to 30 nm.", "Among the plurality of barrier layers, the barrier layer (a p-side barrier layer) closest to the p-type semiconductor layer 12 may be different from another barrier layer, or maybe thicker or thinner than another barrier layer.", "A wavelength (a peak wavelength) of the light (the emitted light) emitted from the light-emitting layer 15 is in a range of 210 nm to 700 nm.", "For example, the peak wavelength of the emitted light may be in a range of 370 nm to 480 nm.", "The p-type semiconductor layer 12 includes, for example, a non-doped AlGaN spacer layer, a Mg-doped p-type AlGaN cladding layer, a Mg-doped p-type GaN contact layer, and a high-concentration Mg-doped p-type GaN contact layer.", "The Mg-doped p-type GaN contact layer is arranged between the high-concentration Mg-doped p-type GaN contact layer and the light-emitting layer 15.The Mg-doped p-type AlGaN cladding layer is arranged between the Mg-doped p-type GaN contact layer and the light-emitting layer 15.The non-doped AlGaN spacer layer is arranged between the Mg-doped p-type AlGaN cladding layer and the light-emitting layer 15.For example, the p-type semiconductor layer 12 includes a non-doped Al0.11Ga0.89N spacer layer, a Mg-doped p-type Al0.28Ga0.72N cladding layer, a Mg-doped p-type GaN contact layer, and a high-concentration Mg-doped p-type GaN contact layer.", "In the aforementioned semiconductor layers, the composition, composition ratio, kind of impurities (dopants), concentration of impurities (dopants) and thickness are merely examples, and various modifications thereof are possible.", "As shown in FIG.", "4B, the recesses 50 are formed.", "For example, the recesses may be formed by selectively etching through a portion of the p-type semiconductor layer 12 and, a portion of the light-emitting layer 15, and then etching into portions of the n-type semiconductor layer 11 all through openings formed in a hard mask 103.The hard mask 103 is, for example, a silicon oxide film.", "An etching depth is in a range of, for example, 0.1 μm to 100 μm.", "Preferably, the etching depth is in a range of 0.4 μm to 2 μm.", "The etching depth is set depending on the width of the recesses 50 across the inner surfaces 50a of the recess 50 in a depth direction.", "The recess 50 is formed at a depth at which the bottom thereof is positioned in the interior portion of the n-type semiconductor layer 11.As the etching depth becomes deeper, the amount of light reflected from the inner surface 50a becomes greater.", "Thus, it is possible to further widen the light dispersion of the semiconductor light-emitting device 1.The recess 50 includes an opening 50p on the front surface of the p-type semiconductor layer 12.Preferably, the minimum width (at the front surface) of the opening 50p is in a range of, for example, 0.1 times to 100 times of the total thickness of the n-type semiconductor layer 11, the light-emitting layer 15 and the p-type semiconductor layer 12.More preferably, the minimum width of the opening 50p is in a range of 0.5 times to 20 times of the total thickness of the n-type semiconductor layer 11, the light-emitting layer 15 and the p-type semiconductor layer 12.As shown in FIG.", "4C, the dielectric film 41 that covers a top surface of the p-type semiconductor layer 12 and inner surfaces of the recesses 50 is next formed.", "The dielectric film 41 is, for example, a silicon oxide film or a silicon nitride film.", "The hard mask 103 is removed by etching thereof before the dielectric film 41 is formed.", "As shown in FIG.", "5A, the portion of the dielectric film 41 formed on bottom surfaces of the recesses 50 is selectively removed, and the n-type semiconductor layer 11 is exposed therethrough.", "Subsequently, as depicted in FIG.", "5A, n electrodes 33, which are electrically connected to the n-type semiconductor layer 11, are formed.", "A material of the n electrode 33 has both an ohmic contact to the n-type semiconductor layer 11 and a high light reflectance, and includes at least one of aluminum (Al) and silver (Ag).", "As shown in FIG.", "5B, the dielectric film 45 that covers both the dielectric film 41 and the n electrodes 33 are formed.", "The dielectric film 45 is, for example, a silicon oxide film.", "As shown in FIG.", "5C, the dielectric films 45 and 41 are selectively etched, and openings 45a and 41a therethrough are formed.", "Thus, the p-type semiconductor layer 12 is exposed in the openings.", "In this stage, the portions of the dielectric film 41 that covers the inner surface from which the portions where the n electrodes 33 are formed are removed, and the dielectric film 45 that covers the n electrodes 33 and the dielectric film 41 is left in the recesses 50.Thereafter, the p electrodes 35 that are electrically connected to the p-type semiconductor layer 12 are formed in the openings in the dielectric film 41.The p electrode 35 includes, for example, Ag.", "As shown in FIG.", "6A, the metal layers 37 and 39 are next formed.", "The metal layer 37 is formed on the p electrode 35 and extends therefrom on the dielectric film 45 to overlies the inner surfaces 50b of the recesses 50 with the dielectric films 41 and 45 interposed therebetween.", "The metal layer 39 is formed on the dielectric film 45, and overlies the inner surfaces 50a of the recesses 50 with the dielectric films 41 and 45.The metal layers 37 and 39 include, for example, Ag.", "As shown in FIG.", "6A, a bonding layer 25a that covers the metal layers 37 and 39 and the exposed portions of the dielectric film 45 between the ends of the metal layers 37 and 39 are formed.", "For example, the bonding layer 25a includes a metal film including at least any one of Ti, Pt and Ni, and a bonding metal.", "For example, the bonding metal includes at least any one of a Ni—Sn alloy, an Au—Sn alloy, a Bi—Sn (bismuth-tin) alloy, a Sn—Cu (tin-copper) alloy, a Sn—In (tin-indium) alloy, a Sn—Ag (tin-silver) alloy, a Sn—Pb (tin-lead) alloy, a Pb—Sn—Sb (lead-tin-antimony) alloy, a Sn—Sb (tin-antimony) alloy, a Sn—Pb—Bi (tin-lead-bismuth) alloy, a Sn—Pb—Cu (tin-lead-copper) alloy, a Sn—Pb—Ag (tin-lead-silver) alloy, and a Pb—Ag (lead-silver) alloy.", "The metal film including at least anyone of Ti, Pt and Ni is formed between the bonding metal and the metal layer 37, between the bonding metal and the metal layer 39, and between the bonding metal and the exposed portions of the dielectric film 45.As shown in FIG.", "6B, the substrate 101 on which the bonding layer 25a is formed and the substrate 20 are positioned to face each other.", "A bonding layer 25b is formed on the top surface of the substrate 20.The bonding layer 25b of the substrate 20 is arranged so as to face the bonding layer 25a of the substrate 101.For example, the bonding layer 25b includes a metal film including at least anyone of Ti, Pt and Ni, and a bonding metal.", "For example, the bonding metal includes at least any one of a Ni—Sn alloy, an Au—Sn alloy, a Bi—Sn alloy, a Sn—Cu alloy, a Sn—In alloy, a Sn—Ag alloy, a Sn—Pb alloy, a Pb—Sn—Sb alloy, a Sn—Sb alloy, a Sn—Pb—Bi alloy, a Sn—Pb—Cu alloy, a Sn—Pb—Ag alloy, and a Pb—Ag alloy.", "The metal film including at least any one of Ti, Pt and Ni is formed between the bonding metal and the substrate 20.As shown in FIG.", "7A, the bonding layers 25a and 25b come in contact with each other, and the substrate 101 and the substrate 20 are heated and pressed together.", "Thus, the bonding layers 25a and 25b are integrated into a single layer, and the bonding layer 25 is obtained.", "FIG.", "7A shows a state in which the configuration of FIG.", "6B is now flipped and the respective semiconductor layers and the substrate 101 are arranged on the substrate 20 with the bonding layer 25 interposed therebetween.", "As shown in FIG.", "7B, the substrate 101 has been removed.", "For example, when the substrate 101 is a silicon substrate, the substrate is removed using a method such as grinding or dry etching (for example, RIE (Reactive Ion Etching)).", "For example, when the substrate 101 is a sapphire substrate, the substrate is removed using LLO (Laser Lift Off).", "A front surface 11a of the n-type semiconductor layer 11 is then provided with fine protrusions, that is, in this example the front surface 11a is roughened (made to be optically unsmooth).", "For example, the front surface 11a of the n-type semiconductor layer 11 is roughened using RIE or a wet process using an alkali etchant.", "As shown in FIG.", "8A, the n-type semiconductor layer 11, the p-type semiconductor layer 12 and the light-emitting layer 15 are selectively removed around the periphery, and the light-emitting member 10 is thus formed.", "For example, the n-type semiconductor layer 11, the light-emitting layer 15 and the p-type semiconductor layer 12 are sequentially etched adjacent the periphery using a method such as RIE or wet etching.", "In this case, the n electrodes 33 at the bonding pads are then exposed (see FIG.", "2A).", "For example, the n electrodes are formed by performing CVD (Chemical Vapor Deposition) on the silicon oxide film which becomes the dielectric film 47.For example, a thickness of the silicon oxide film is approximately 200 nm (preferably, in a range of 50 nm to 400 nm).", "The bonding pads 31 are formed by removing the dielectric film 47 on the n electrodes 33 in the regions where the bonding pads 31 are formed.", "As shown in FIG.", "8B, the dielectric films 47, 41 and 45 on the periphery of the light-emitting member 10 are selectively removed (set back from the edge), and a dicing region 40e is formed.", "Subsequently, the bonding layer 25 and the substrate 20 are cut through using, for example, a dicer or a scriber, to form individual devices, and the semiconductor light-emitting device 1 is thus manufactured as a singulated chip.", "In the aforementioned example, the refractive index of the silicon oxide film used as the dielectric films 41, 45 and 47 is approximately 1.47 (a wavelength of 450 nm), and the refractive index of GaN used as the n-type semiconductor layer 11 and the p-type semiconductor layer 12 is approximately 2.5 (a wavelength of 450 nm).", "Accordingly, light which is incident on an interface between the n-type semiconductor layer 11 and the dielectric film 41 and an interface between the n-type semiconductor layer 11 and the dielectric film 47 from the n-type semiconductor layer 11 at an incident angle greater than a critical angle is totally reflected.", "That is, most light which propagates through the inside of the light-emitting member 10 toward the side surface 10c is reflected from the side surface 10c (the interface between the n-type semiconductor layer 11 and the dielectric film 47).", "At least a portion of the light reflected from the side surface 10c is reflected from the inner surface 50a of the recess 50 (the interface between the n-type semiconductor layer or the p-type semiconductor layer and the dielectric film 41).", "The light which passes through the inner surface 50a and propagates toward the bonding layer 25 is reflected from the metal layer 39, and is returned to the light-emitting member 10.As a result, light may be repeatedly reflected between the side surface 10c and the inner surface 50a.", "That light incident on the side surface 10c at an angle less than the critical angle is emitted to the outside from the side surface 10c.", "Thus, the light emitted from the side surface 10c of the light-emitting member 10 is increased, and thus, it is possible to widen the area of light dispersion of the semiconductor light-emitting device 1.In addition to the silicon oxide film, silicon nitride or silicon oxynitride may be used as the dielectric films 41, 45 and 47.Alternatively, metal oxide using at least any one of Al (aluminum), Zr (zirconium), Ti (titanium), Nb (niobium) and Hf (hafnium), metal nitride using at least any one thereof, or metal oxynitride using at least anyone thereof maybe used.", "Second Embodiment FIG.", "9A is a schematic top view showing a semiconductor light-emitting device 2 according to a second embodiment.", "FIGS.", "9B and 9C are schematic sectional views of a major part of the semiconductor light-emitting device 2.FIG.", "9B shows a section taken along line D-D shown in FIG.", "9A, and FIG.", "9C shows a section taken along line E-E shown in FIG.", "9A.", "The semiconductor light-emitting device 2 includes a light-emitting member 10, and a substrate 20.The light-emitting member 10 is provided on the substrate 20.FIG.", "9A is a top view showing an electrode surface on the bottom of the light-emitting member 10.A broken line of FIG.", "9A indicates an outer periphery of the light-emitting member 10.As shown in FIG.", "9A, the semiconductor light-emitting device 2 includes n electrodes 33 and p electrodes 35 formed on the bottom of the light-emitting member 10.In the present embodiment, the p electrode 35 includes a portion (an extension portion 35p) that extends to a location adjacent to a side of the light-emitting member 10, and a bonding pad 32 is formed on the extension portion 35p.", "The light-emitting member 10 includes a recess 50 that extends along an outer periphery of the p electrode 35.The recess 50 includes inner surfaces 50a and 50b.", "The inner surface 50a extends along the outer periphery of the light-emitting member 10.The inner surface 50b extends along the outer periphery of the p electrode 35.The light-emitting member 10 includes a plurality of recesses 55 extending thereinto.", "The recesses 55 are spaced from the p electrode 35 so that they are isolated from the p electrode 35.The n electrodes 33 are respectively formed in the recesses 55.As shown in FIG.", "9B, the light-emitting member 10 is provided on the substrate 20 with a bonding layer 25 interposed therebetween.", "The light-emitting member 10 includes an n-type semiconductor layer 11, a p-type semiconductor layer 12, and a light-emitting layer 15.The light-emitting layer 15 is formed between the n-type semiconductor layer 11 and the p-type semiconductor layer 12.The light-emitting member 10 includes a first surface 10a including a front surface of the n-type semiconductor layer 11, a second surface 10b including a front surface of the p-type semiconductor layer 12, and a side surface 10c including an outer periphery of the n-type semiconductor layer 11.Preferably, the first surface 10a has a light extraction structure.", "A dielectric film 47 covers the first surface 10a and the side surfaces 10c.", "The recess 50 and the recesses 55 are formed in the second surface 10b.", "The inner surface 50a of the recess 50 is on the side of the recess 50 that faces the side surface 10c of the light-emitting member 10.The n electrodes 33 and the p electrodes 35 are formed between the light-emitting member 10 and the bonding layer 25.A dielectric film 45 is formed between the p electrodes 35 and the bonding layer 25.The dielectric film 45 covers the inner surfaces of the recess 50 and the front surface of the p-type semiconductor layer 12.The n electrodes 33 are respectively formed on bottom surfaces of the recesses 55, and are electrically connected to the n-type semiconductor layer 11.The bonding layer 25 extends in the recesses 55, and is in contact with the n electrodes 33.That is, the n electrodes 33 are electrically connected to the substrate 20 with the bonding layer 25 interposed therebetween.", "The p electrodes 35 are formed between the p-type semiconductor layer 12 and the dielectric film 45, and are electrically connected to the p-type semiconductor layer 12.The p electrodes 35 are electrically insulated from the bonding layer 25 and the substrate 20 by the dielectric film 45.As shown in FIG.", "9C, the extension portion 33p of the p electrode 33 extends over the bonding layer 25 with the dielectric film 45 interposed therebetween.", "The bonding pad 32 is formed on the extension portion 33p.", "For example, the p electrodes 33 are electrically connected to an external circuit through metal wires connected to the bonding pads 32.The dielectric film 45 includes a protrusion 45p outside the extension portion 35p.", "The protrusion 45p is a portion formed in the recess 50, and is exposed after the n-type semiconductor layer 11, the light-emitting layer 15 and the p-type semiconductor layer 12 are selectively removed.", "The recess 50 forms the inner surface 50a facing the side surface 10c of the light-emitting member 10.The inner surface 50a reflects the light which is reflected from the side surface 10c and propagates it back toward the side surface 10c.", "Thus, the light emitted from the side surface 10c is increased, and thus, it is possible to widen the area of light dispersion of the semiconductor light-emitting device 2.The p-type semiconductor layer 12 includes a first portion 12a between the side surface 10c and the inner surface 50a, and a second portion 12b that is electrically connected to the p electrodes 35.The first portion 12a is formed along the outer periphery of the light-emitting member 10.The first portion 12a is electrically insulated from the bonding layer 25 and the substrate 20 by the dielectric film 45.Accordingly, drive current does not flow to the first portion 12a, and the light-emitting layer 15 between the first portion 12a and the n-type semiconductor layer 11 does not radiate light.", "Third Embodiment FIG.", "10A is a schematic top view showing a semiconductor light-emitting device 3 according to a third embodiment, and FIG.", "10B is a section of a portion of the light-emitting device taken along line F-F shown in FIG.", "10A.", "The semiconductor light-emitting device 3 includes a light-emitting member 10, and a substrate 20.The light-emitting member 10 is provided on the substrate 20.As shown in FIG.", "10A, the semiconductor light-emitting device 3 in this third embodiment includes the n electrode 33 located on the exterior surface side of the light-emitting member 10, that is, here n electrode 33 is not in the recess 50 like it was in the first two embodiments.", "The n electrode 33 includes a portion 33a that surrounds the opening through which light is emitted, and generally bisects that opening, and integral bonding pads 33b formed as extensions thereof extending toward the side of the device 3.The light-emitting member 10 includes a recess 50 extending inwardly thereof at the side opposite to where the n electrode is located, and the recess extending around, at a location slightly inwardly of, the outer periphery thereof.", "The recess 50 includes inner surfaces 50a and 50b.", "The inner surface 50a extends along the side surface 10c in the outer periphery of the light-emitting member 10.As shown in FIG.", "10B, the light-emitting member 10 is provided on the substrate 20 with a bonding layer 25 interposed therebetween.", "The light-emitting member 10 includes an n-type semiconductor layer 11, a p-type semiconductor layer 12, and a light-emitting layer 15.The light-emitting layer 15 is formed between the n-type semiconductor layer 11 and the p-type semiconductor layer 12.The light-emitting member 10 includes a first surface 10a including a front surface of the n-type semiconductor layer 11, a second surface 10b including a front surface of the p-type semiconductor layer 12, and a side surface 10c including an outer periphery of the n-type semiconductor layer 11.Preferably, the portion of the first surface 10a where the n electrode 33 is not formed has a light extraction structure.", "The recess 50 is formed in the second surface 10b.", "The inner surface 50a of the recess 50 is on the side of the recess 50 that faces the side surface 10c of the light-emitting member 10.The p-type semiconductor layer 12 includes a first portion 12a between the side surface 10c and the recess 50, and a second portion 12b surrounded by the recess 50.A p electrode 35 is formed between the second portion 12b and the bonding layer 25.The p electrode 35 is electrically connected to the second portion 12b.", "The p electrode 35 is electrically connected to the substrate 20 with the bonding layer 25 interposed therebetween.", "Meanwhile, a dielectric film 45 is formed between the first portion 12a and the bonding layer 25.The dielectric film 45 covers the inner surfaces of the recess 50.The first portion 12a of the p-type semiconductor layer 12 is electrically insulated from the bonding layer 25 and the substrate 20 by the dielectric film 45.The recess 50 according to the present embodiment is formed to have the inner surface 50a on a side thereof facing the side surface 10c of the light-emitting member 10.The inner surface 50a reflects light which is reflected from the side surface 10c and propagates toward the bonding layer 25, and returns the light toward the side surface 10c.", "Thus, the light is emitted from the side surface 10c, and thus, it is possible to widen the light dispersion of the semiconductor light-emitting device 3.The first portion 12a of the p-type semiconductor layer 12 is formed along an outer periphery of the light-emitting member 10.The first portion 12a is electrically insulated from the bonding layer 25 and the substrate 20 by the dielectric film 45.For this reason, drive current does not flow to the first portion 12a, and the light-emitting layer 15 between the first portion 12a and the n-type semiconductor layer 11 does not radiate light.", "In other words, an electric field is not generated in the light-emitting layer 15 exposed to the side surface 10c of the light-emitting member 10.Accordingly, it is possible to omit the dielectric film 47 that protects an end of the light-emitting layer 15.FIGS.", "11A and 11B are schematic top vies showing semiconductor light-emitting devices 4 and 5 according to modification examples of the third embodiment.", "As shown in the drawing, the semiconductor light-emitting devices 4 and 5 are different from the semiconductor light-emitting device 3 in view of the arrangement of the recess 50.As shown in FIG.", "11A, a recess 50 extends along one side of a light-emitting member 10.An inner surface 50a of the recess 50 is thus formed only along one side surface 10c of the light-emitting member 10.Thus, it is possible to increase the amount of light emitted from the side surface 10c facing the inner surface 50a.", "In other words, the recess 50 is formed along the side surface 10c in which light dispersion is widened in the semiconductor light-emitting device 4.The recess 50 is not limited to be arranged along one side surface 10c, but may be arranged along two or three side surfaces 10c.", "As shown in FIG.", "11B, a plurality of recesses 50 may be formed along an outer periphery of the light-emitting member 10.Each recess 50 is formed in an island shape, i.e., each recess 50 is spaced from adjacent recesses 50, and a length of each recess 50 in a direction along the outer periphery of the light-emitting member 10 is less than a length of one side of the light-emitting member 10.Each of the recesses 50 includes an inner surface 50a facing the side surface 10c of the light-emitting member 10.The recess 50 reflects light which is reflected from the side surface 10c and propagates the light toward the side surface 10c.", "Thus, the quantity of light emitted from the side surface 10c is increased, and thus, it is possible to widen the light dispersion of the semiconductor light-emitting device 5.In the examples shown in FIGS.", "11A and 11B, a p-type semiconductor layer 12 between the side surface 10c of the light-emitting member 10 and the recess 50 is electrically connected to the p electrode 35.For this reason, it is preferable that a dielectric film 47 which covers the side surface 10c of the light-emitting member 10 is formed.", "As discussed above, the aspects of the present disclosure has been described by referring to the specific examples.", "However, the embodiments of the present disclosure are not limited to these specific examples.", "That is, the design variations of these specific examples performed by a person skilled in the art may be included the scope of the present disclosure.", "The elements included in the specific examples described above, the arrangement, the materials, the conditions, the shapes, and the sizes thereof are not limited to the examples, but may be appropriately changed.", "In the embodiments, it is assumed that the “nitride semiconductor” includes semiconductors having all compositions obtained by changing the range composition ratios x, y and z in a chemical formula of BxInyAlzGa1-x-y-zN (0≤x≤1, 0≤y≤1, 0≤z≤1, x+y+z≤1) within the respective ranges.", "Furthermore, it is assumed that the “nitride semiconductor” includes semiconductors which further include elements in group V other than N (nitride) in the aforementioned chemical formula, semiconductors which further include various elements added to control various properties such as a conductivity type, and semiconductors which further include various elements which are unintentionally included.", "In the present disclosure, “on” as used in the phrase “a portion A is formed on a portion B” may include a case where the portion A is not in direct contact with the portion B, (e.g., the portion A is formed above the portion B) also a case where the portion A is in direct contact with the portion B (e.g., the portion A is formed directly on the portion B).", "The phrase “portion A is formed on the portion B” applies to a case where the portion A and the portion B are exchanged in position (e.g., along the layer stack direction) and the portion A is positioned above or under the portion B, and also applies to a case where the portion A and the portion B are arranged side by side (e.g., adjacent to each other in a same layer plane or the like).", "This is because even though the semiconductor light-emitting devices according to the embodiments are rotated, the structures of the semiconductor light-emitting devices are not changed before and after the rotation.", "While certain embodiments have been described, these embodiments have been presented by way of example only, and are not intended to limit the scope of the inventions.", "Indeed, the novel embodiments described herein may be embodied in a variety of other forms; furthermore, various omissions, substitutions and changes in the form of the embodiments described herein may be made without departing from the spirit of the inventions.", "The accompanying claims and their equivalents are intended to cover such forms or modifications as would fall within the scope and spirit of the inventions." ] ]
Patent_15875887
[ [ "Workpiece Support Structures and Apparatus for Accessing Same", "A workpiece container stores at least one workpiece having a bottom surface and a peripheral edge.", "In one embodiment, a workpiece support structure is located within the container enclosure, which forms multiple vertically stacked storage shelves within the enclosure.", "Each storage shelf includes, in one embodiment, a first tine and a second tine for supporting the workpiece in a substantially horizontal orientation.", "The bottom surface and peripheral edge of a workpiece seated on a storage shelf extends beyond the outer edge of both the first tine and the second tine.", "An end effector may engage these extended portions or “grip zones” of the workpiece." ], [ "1.An end effector comprising: a body; a first arm attached to and extending from the body in a direction, a second arm attached to and extending from the body in the direction; each of the first and second arms having a proximal end closer to the body than a distal end; a distal support pad extending from each of the first and second arms towards the other arm, the distal support pad located closer to the distal end than to the proximal end, wherein the distal support pads are located close to a peripheral edge of a workpiece when present, and wherein the distal support pads are located in a retracted position to facilitate travel of the first and second arms vertically within an enclosure of a container, wherein the distal support pads are located in a support position to support the workpiece when present in the container, wherein the first and second arms move closer or away from each other, wherein in the retracted position, the first and second arms are away from each other and do not support the workpiece, and in the support position, the first and second arms are closer to each other.", "2.The end effector of claim 1, wherein each of the first and second arms is curved between the proximal end and the distal end, wherein the body has a portion that is straight.", "3.The end effector of claim 1, further comprising a finger extending from the body in the direction, wherein the finger is straight and is located between the first and second arms, when the finger has a portion that is a contact surface extending from the finger to support the workpiece when present.", "4.The end effector of claim 3, wherein the finger has a shorter length in the direction compared to a length of each of the first and second arms in the direction.", "5.The end effector of claim 1, further comprising: an additional support pad extending from the first arm towards the second arm and located between the proximal end of the first arm and the distal end of the first arm; an additional support pad extending from the second arm towards the first arm and located between the proximal end of the second arm and the distal end of the second arm, wherein the additional support pads are configured to support the workpiece when present, wherein the proximal end of each of the first and second arms is contiguous with the body.", "6.The end effector of claim 5, wherein each of the distal support pads has a contact surface that extends in a horizontal direction and a backstop that extends in a vertical direction with respect to the contact surface, wherein each of the additional support pads has a contact surface that extends in the horizontal direction and a backstop that extends in the vertical direction with respect to the contact surface of the additional support pad.", "7.The end effector of claim 6, wherein each backstop of the distal support pads is configured to extend in the vertical direction to prevent the workpiece from sliding from each respective contact surface of the distal support pads, wherein each backstop of the additional support pads is configured to extend in the vertical direction to prevent the workpiece from sliding from the contact surface of each of the additional support pads.", "8.A system comprising: a container having a plurality of base members, the container further having a plurality of tines that extend from the base members into an interior space of the container; and an end effector including: a body; a first arm attached to and extending from the body in a direction, a second arm attached to and extending from the body in the direction; each of the first and second arms having a proximal end closer to the body than a distal end; and a distal support pad extending from each of the first and second arms towards the other arm, the distal support pad located closer to the distal end than to the proximal end, wherein the distal support pads are located in a retracted position to facilitate travel of the first and second arms vertically within the interior space of the container, wherein the distal support pads are located in a support position to support a workpiece when present in the container, wherein in the retracted position, the distal support pads are away from each other and do not support the workpiece, and in the support position, the distal support pads are closer to each other.", "9.The system of claim 8, wherein each of the first and second arms is curved between the proximal end and a distal end, wherein the body has a portion that is straight.", "10.The system of claim 8, wherein the end effector comprises a finger extending from the body in the direction, wherein the finger is straight and is located between the first and second arms, when the finger has a portion that is a contact surface extending from the finger to support the workpiece when present.", "11.The system of claim 10, wherein the finger has a shorter length in the direction compared to a length of each of the first and second arms in the direction.", "12.The system of claim 8, wherein the end effector comprises: an additional support pad extending from the first arm towards the second arm and located between the proximal end of the first arm and the distal end of the first arm; an additional support pad extending from the second arm towards the first arm and located between the proximal end of the second arm and the distal end of the second arm, wherein the additional support pads are configured to support the workpiece when present, wherein the proximal end of each of the first and second arms is contiguous with the body.", "13.The system of claim 12, wherein each of the distal support pads has a contact surface that extends in a horizontal direction and a backstop that extends in a vertical direction with respect to the contact surface, wherein each of the additional support pads has a contact surface that extends in the horizontal direction and a backstop that extends in the vertical direction with respect to the contact surface of the additional support pad.", "14.The system of claim 13, wherein each backstop of the distal support pads is configured to extend in the vertical direction to prevent the workpiece from sliding from each respective contact surface of the distal support pads, wherein each backstop of the additional support pads is configured to extend in the vertical direction to prevent the workpiece from sliding from the context surface of each of the additional support pads.", "15.An end effector comprising: a body having a length that extends in a direction; a first arm attached to and extending from the body in the direction, a second arm attached to and extending from the body in the direction; each of the first and second arms having a proximal end closer to the body than a distal end; and a distal support pad extending from each of the first and second arms towards the other arm, the distal support pad located closer to the distal end than to the proximal end, wherein the distal support pads are located in a retracted position to facilitate travel of the first and second arms vertically within an enclosure of a container, wherein the distal support pads are located in a support position to support a workpiece when present in the container, wherein in the retracted position, the distal support pads are away from each other and do not support the workpiece, and in the support position, the distal support pads are closer to each other.", "16.The end effector of claim 15, wherein each of the first and second arms is curved between the proximal end and a distal end, wherein the body has a portion that is straight.", "17.The end effector of claim 15, further comprising a finger extending from the body in the direction, wherein the finger is straight, when the finger has a portion that is a contact surface extending from the finger to support the workpiece when present.", "18.The end effector of claim 17, wherein the finger has a shorter length in the direction compared to a length of each of the first and second arms in the direction.", "19.The end effector of claim 15, further comprising: an additional support pad extending from the first arm towards the second arm and located between the proximal end of the first arm and the distal end of the first arm; an additional support pad extending from the second arm towards the first arm and located between the proximal end of the second arm and the distal end of the second arm, wherein the additional support pads are configured to support the workpiece when present, wherein the proximal end of each of the first and second arms is contiguous with the body.", "20.The end effector of claim 19, wherein each of the distal support pads has a contact surface that extends in a horizontal direction and a backstop that extends in a vertical direction with respect to the contact surface, wherein each of the additional support pads has a contact surface that extends in the horizontal direction and a backstop that extends in the vertical direction with respect to the contact surface of the additional support pad, wherein each backstop of the distal support pads is configured to extend in the vertical direction to prevent the workpiece from sliding from each respective contact surface of the distal support pads, wherein each backstop of the additional support pads is configured to extend in the vertical direction to prevent the workpiece from sliding from the context surface of each of the additional support pads." ], [ "<SOH> BACKGROUND <EOH>Conventional wafer containers, such as a Front Opening Unified Pod (FOUP) or a Standard Mechanical Interface (SMIF) pod, often contain shelves of fixed-pitch spacing to support the semiconductor wafers.", "FIG.", "1 illustrates one embodiment of a conventional FOUP 10 .", "The FOUP 10 includes a housing or shell 12 and a FOUP door 14 that mechanically couples with the FOUP shell 12 .", "The housing 12 , which includes a top 18 , a back 20 , a first side 22 , a second side 24 and a bottom 26 , defines an enclosure 28 .", "The enclosure includes a support 30 located on the interior surface 32 of the first side 22 and the interior surface (not shown) of the second side 24 .", "Each support 30 includes multiple shelves 16 .", "Each slot between a pair of shelves 16 stores a single wafer.", "Each support 30 covers a portion of the wafer's peripheral edge while the wafer is seated in the FOUP 10 .", "Access to the outside edge of the wafer is blocked by the shelf structure.", "Wafers are therefore typically handled by thin-bladed end effectors that must reach between adjacent wafers and subsequently either secure the wafer with a vacuum chuck or some type of edge support and/or gripping arrangement.", "These methods of securing the wafer often support the wafer by the wafer's back and front edges or elsewhere on the back edges.", "This conventional wafer securing approach has been in widespread use in the semiconductor manufacturing industry for over twenty-five years.", "But this approach has a number of shortcomings that become more serious as the wafer size becomes larger.", "Also, increasing use is being made of thinned wafers, which are prone to significant bending deflections when supported by the edge.", "Some of the deficiencies of conventional wafer support and carrier architectures include: 1) Wafer Mapping—Break-the-beam mapping has proven to be the most reliable method of determining a wafer's presence or absence and its vertical position within the container.", "However, break-the-beam mapping with the 300 mm FOUP architecture requires expensive and complex mechanisms to position sensing elements into the container.", "2) End effector blade travel zone—To access a wafer, the end effector blade must first travel between adjacent wafers until it reaches a desired position, and at that position, lift the wafer from the support shelf.", "As wafer diameter increases, the mass of the wafer and the blade length required to support the wafer also increases.", "To maintain reasonable deflection characteristics of the end effector for larger diameter wafers, the end effector blade must be thicker.", "If the thickness of the end effector blade increases, the pitch between the wafers must also increase to allow the thicker end effector to pass between wafers without contacting the wafers.", "Either container size will have to increase or fewer wafers can be stored in conventional containers.", "Additionally, the extra travel length of the end effector is subject to wafer bow, distortion and warping, as well as the vibration characteristics of the end effector due to the rapid horizontal and vertical motions required for time efficient wafer handling.", "All of this must be accomplished without any accidental contact between a moving end effector and a wafer.", "Contact between the end effector and a wafer will likely to cause serious damage to sensitive circuits on the wafer as well as generating particle bursts that may contaminate all the other wafers in the container.", "3) End effector travel path efficiency—A conventional end effector places a wafer in a container and then withdraws to enable vertical motion clearance for randomly accessing the next wafer, which is then withdrawn and taken to a process or metrology location.", "Thus, four horizontal moves are required for each wafer exchange at the container.", "4) Process/Metrology chuck complexity—Typically, wafers are placed on flat chucks or platens for processing or measurement.", "In many applications, the wafer is secured to the chuck (and planarized) by applying vacuum.", "Use of conventional vacuum or edge grip end effectors necessitates large cutaway areas in the chuck to enable release of the wafer and withdrawal of the end effector blade.", "5) Multiple wafer handling—It is very difficult in today's architecture to pick or place multiple wafers simultaneously or to enable individual selection of desired wafers in a mass transfer mode.", "Thus, it would be advantageous to have an end effector with these features.", "The various embodiments of an end effector and a tine structure described herein provide such features." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>One aspect of the present disclosure is to provide a new apparatus for supporting semiconductor wafers or substrates.", "In one embodiment, the present disclosure comprises a structure that enables storage and transport of one or more wafers as well as random access pick and place handling of individual wafers or groups of wafers.", "Another aspect of the present disclosure is to provide a tine structure that supports each wafer by a pair of cantilevered structures.", "In one embodiment, the pair of cantilevered structures each includes two contact surfaces for supporting the wafer; one contact surface at the distal end and the other contact surface at the proximal end.", "While a wafer is seated on the cantilever structures, the peripheral edge of the wafer is exposed or accessible by an end effector.", "A portion of the wafer's bottom surface is also exposed or accessible by an end effector, and in one embodiment is referred to as a “grip zone.” In another embodiment, each cantilever structure includes a third contact surface.", "Yet another aspect of the present disclosure is to provide a tine structure whereby an end effector may travel along the outside of the support structure between wafers.", "In one embodiment, the pair of cantilevered structures are spaced apart such that a portion of a wafer, seated on the cantilever structures, extends out beyond the outer edge of each cantilever structure.", "An end effector according to the present disclosure may then travel between wafers along the outside of each wafer; eliminating the need to travel across the entire wafer surface simply to lift a wafer off the support shelves.", "In one embodiment, the end effector travels along the outside of the wafer until the end effector is at a height whereby the end effector arms can be positioned underneath the wafer.", "This distance, by way of example only, comprises a few millimeters, and does not require the end effector to travel across the wafer surface." ], [ "CLAIM OF PRIORITY This application is a continuation of and claims priority, under 35 USC § 120, to U.S. patent application Ser.", "No.", "14/452,490, filed on Aug. 5, 2014, and entitled “Workpiece Support Structures and Apparatus for Accessing Same”, which is a continuation of and claims priority, under 35 USC § 120, to U.S. patent application Ser.", "No.", "13/337,028, filed on Dec. 23, 2011, issued as U.S. Pat.", "No.", "8,800,774 on Aug. 12, 2014, and entitled “Workpiece Support Structures and Apparatus for Accessing Same”, which is a continuation of and claims priority, under 35 USC § 120, to U.S. patent application Ser.", "No.", "11/483,366, filed on Jul.", "7, 2006, and entitled “Workpiece Support Structures and Apparatus for Accessing Same”, which claims priority, under 35 U.S.C.", "§ 119(e), to U.S.", "Provisional Patent Application No.", "60/697,528, entitled “End Effector Tine and Transfer Methods,” which was filed on Jul.", "8, 2005, all of which are incorporated herein by reference herein in their entirety.", "FIELD The present disclosure generally comprises workpiece support structures and a workpiece transfer apparatus for accessing the workpieces stored in the structures.", "More specifically, the present disclosure comprises a structure for supporting the workpieces such that the transfer device may randomly access any of the workpieces stored in the carrier.", "BACKGROUND Conventional wafer containers, such as a Front Opening Unified Pod (FOUP) or a Standard Mechanical Interface (SMIF) pod, often contain shelves of fixed-pitch spacing to support the semiconductor wafers.", "FIG.", "1 illustrates one embodiment of a conventional FOUP 10.The FOUP 10 includes a housing or shell 12 and a FOUP door 14 that mechanically couples with the FOUP shell 12.The housing 12, which includes a top 18, a back 20, a first side 22, a second side 24 and a bottom 26, defines an enclosure 28.The enclosure includes a support 30 located on the interior surface 32 of the first side 22 and the interior surface (not shown) of the second side 24.Each support 30 includes multiple shelves 16.Each slot between a pair of shelves 16 stores a single wafer.", "Each support 30 covers a portion of the wafer's peripheral edge while the wafer is seated in the FOUP 10.Access to the outside edge of the wafer is blocked by the shelf structure.", "Wafers are therefore typically handled by thin-bladed end effectors that must reach between adjacent wafers and subsequently either secure the wafer with a vacuum chuck or some type of edge support and/or gripping arrangement.", "These methods of securing the wafer often support the wafer by the wafer's back and front edges or elsewhere on the back edges.", "This conventional wafer securing approach has been in widespread use in the semiconductor manufacturing industry for over twenty-five years.", "But this approach has a number of shortcomings that become more serious as the wafer size becomes larger.", "Also, increasing use is being made of thinned wafers, which are prone to significant bending deflections when supported by the edge.", "Some of the deficiencies of conventional wafer support and carrier architectures include: 1) Wafer Mapping—Break-the-beam mapping has proven to be the most reliable method of determining a wafer's presence or absence and its vertical position within the container.", "However, break-the-beam mapping with the 300 mm FOUP architecture requires expensive and complex mechanisms to position sensing elements into the container.", "2) End effector blade travel zone—To access a wafer, the end effector blade must first travel between adjacent wafers until it reaches a desired position, and at that position, lift the wafer from the support shelf.", "As wafer diameter increases, the mass of the wafer and the blade length required to support the wafer also increases.", "To maintain reasonable deflection characteristics of the end effector for larger diameter wafers, the end effector blade must be thicker.", "If the thickness of the end effector blade increases, the pitch between the wafers must also increase to allow the thicker end effector to pass between wafers without contacting the wafers.", "Either container size will have to increase or fewer wafers can be stored in conventional containers.", "Additionally, the extra travel length of the end effector is subject to wafer bow, distortion and warping, as well as the vibration characteristics of the end effector due to the rapid horizontal and vertical motions required for time efficient wafer handling.", "All of this must be accomplished without any accidental contact between a moving end effector and a wafer.", "Contact between the end effector and a wafer will likely to cause serious damage to sensitive circuits on the wafer as well as generating particle bursts that may contaminate all the other wafers in the container.", "3) End effector travel path efficiency—A conventional end effector places a wafer in a container and then withdraws to enable vertical motion clearance for randomly accessing the next wafer, which is then withdrawn and taken to a process or metrology location.", "Thus, four horizontal moves are required for each wafer exchange at the container.", "4) Process/Metrology chuck complexity—Typically, wafers are placed on flat chucks or platens for processing or measurement.", "In many applications, the wafer is secured to the chuck (and planarized) by applying vacuum.", "Use of conventional vacuum or edge grip end effectors necessitates large cutaway areas in the chuck to enable release of the wafer and withdrawal of the end effector blade.", "5) Multiple wafer handling—It is very difficult in today's architecture to pick or place multiple wafers simultaneously or to enable individual selection of desired wafers in a mass transfer mode.", "Thus, it would be advantageous to have an end effector with these features.", "The various embodiments of an end effector and a tine structure described herein provide such features.", "SUMMARY OF THE INVENTION One aspect of the present disclosure is to provide a new apparatus for supporting semiconductor wafers or substrates.", "In one embodiment, the present disclosure comprises a structure that enables storage and transport of one or more wafers as well as random access pick and place handling of individual wafers or groups of wafers.", "Another aspect of the present disclosure is to provide a tine structure that supports each wafer by a pair of cantilevered structures.", "In one embodiment, the pair of cantilevered structures each includes two contact surfaces for supporting the wafer; one contact surface at the distal end and the other contact surface at the proximal end.", "While a wafer is seated on the cantilever structures, the peripheral edge of the wafer is exposed or accessible by an end effector.", "A portion of the wafer's bottom surface is also exposed or accessible by an end effector, and in one embodiment is referred to as a “grip zone.” In another embodiment, each cantilever structure includes a third contact surface.", "Yet another aspect of the present disclosure is to provide a tine structure whereby an end effector may travel along the outside of the support structure between wafers.", "In one embodiment, the pair of cantilevered structures are spaced apart such that a portion of a wafer, seated on the cantilever structures, extends out beyond the outer edge of each cantilever structure.", "An end effector according to the present disclosure may then travel between wafers along the outside of each wafer; eliminating the need to travel across the entire wafer surface simply to lift a wafer off the support shelves.", "In one embodiment, the end effector travels along the outside of the wafer until the end effector is at a height whereby the end effector arms can be positioned underneath the wafer.", "This distance, by way of example only, comprises a few millimeters, and does not require the end effector to travel across the wafer surface.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 provides a perspective view of a FOUP, according to the prior art; FIGS.", "2A-2B provide a cross-sectional plan view and a side elevation view of an embodiment of the present disclosure; FIG.", "3 provides a plan view of another embodiment of the present disclosure; FIG.", "4 provides a perspective view of another embodiment of the present disclosure; FIG.", "5 provides a perspective view of yet another embodiment of the present disclosure; FIG.", "6 provides a perspective view of still another embodiment of the present disclosure; FIG.", "7 provides a perspective view of another embodiment of the present disclosure; FIG.", "8 provides a perspective view of yet another embodiment of the present disclosure; FIG.", "9 provides a plan view of yet another embodiment of the present disclosure; and FIG.", "10 provides a cross-sectional plan view of the container shown in FIG.", "10 in conjunction with one embodiment of an end effector according to the present disclosure.", "DETAILED DESCRIPTION For the purposes of describing this invention only, the workpiece support structure 102 will be described in reference to a carrier or container.", "A container or carrier may include, but is not limited to, a moveable, closed or open structure used to hold, store, transport or protect semiconductor wafers, substrates, flat panel displays and the like.", "Such a container includes, but is not limited to, a wafer cassette, a Standard Mechanical Interface (SMIF) pod, and a Front Opening Unified Pod (FOUP).", "For containers that include mechanically openable doors, the present disclosure may be used in conjunction with front opening and/or bottom opening containers.", "Of course, the workpiece support structure 102 is not limited to such containers and may be used in conjunction with any type of workpiece storage needs.", "FIGS.", "2 and 4-8 illustrate one embodiment of a support structure 102.In this embodiment, each support structure 102 includes a base member 104 and multiple tines 106.Each tine 106 forms a cantilevered structure extending or projecting from the base member 104.A tine 106 may comprise any shape including, but not limited to, a flat surface, a shape having a rectangular cross-sectional area, a shape having a circular cross-sectional area, and so on.", "FIG.", "2A illustrates that each tine 106 is separated by a distance dl, which in a preferred embodiment, comprises 10 mm.", "The distance dl may comprise other distances as well.", "There is no ideal distance dl.", "The distance dl simply must be large enough such that a wafer W may be vertically lifted off a storage shelf (e.g., tines 106b1 and 106b2 in FIG.", "4) to a height whereby the wafer W may be removed from the storage shelf, and the wafer does not contact the storage shelf located directly above (e.g., tines 106a1 and 106a2 in FIG.", "4).", "FIGS.", "4-8 illustrate the support structure 102 in use with a bottom opening container.", "The base member 104 shown in FIG.", "4 extends upward from the container door 12.The base member 104 may comprise a structure separate from the container door 12 or may comprise a structure that is part of the container door 12.Any number of tines 106 may extend or project from a base member 104, and the number of tines 106 simply determines how many wafers may be stored in a carrier if the support structure is located within a carrier (each pair of tines 106, or storage shelf, supports a single wafer).", "For example, the wafer supports 102 shown in FIG.", "4 each include a base member 104 and four tines 106.Thus, the support structure 102 shown in FIG.", "4 may store up to four wafers W. Each wafer W is supported by a pair of tines 106, which may be referred to as a storage shelf.", "FIG.", "4 illustrates that the uppermost pair of tines 106a1 and 106a2 are not occupied by a wafer; tines 106b1 and 106b2 are supporting wafer W1; tines 106c1 and 106c2 are supporting wafer W2; and tines 106d1 and 106d2 are supporting wafer W3.Each pair of tines 106 preferably support the wafer W in a substantially horizontal orientation so that the wafers W are substantially parallel to each other.", "FIG.", "4 shows that the tines 106 are molded into the base member 104.Each tine 106 may also comprise a separate component affixed or secured to the base member 104.FIG.", "2A illustrates that a tine 106 includes a first end or proximal end 112, a second end or distal end 114 and an outer edge 107.If the support structure 102 is located within a FOUP, the outer edge 107 of each tine 106 faces the interior of the container shell 12 (e.g., surface 32 of a FOUP side wall 22—as shown in FIG.", "1).", "The tines 106 preferably support a wafer W with a minimum amount of contact with the wafer's bottom surface or peripheral edge P. In this embodiment, each tine 106 contacts or supports the wafer W with only two surfaces—a first support 108 and a second support 110.The first support 108 is located at or near the first end 112 of the tine 106.The second support 110 is located at or near the second end 114 of the tine 106.It is within the scope of the present disclosure for other portions of the tine 106 to contact the wafer W. In addition, the first and second supports 108 and 110 may be located elsewhere along the tine 106.It is also within the scope of the present disclosure for a tine 106 to have only one support while other supports are provided by the base member 104.In a preferred embodiment, each storage shelf includes at least three supports shared between the base member(s) 104 and the two tines 106.FIG.", "2A further illustrates that a tine 106 may also include an additional support 116.In the FIG.", "2A embodiment, a structure 118 extends from the tine 106 somewhere between the proximal end 112 and the distal end 114 of the tine 106.The additional support 116 is preferably located at the distal end 119 of the structure 118, but may, of course, be located anywhere along the structure 118.The additional support 116 provides an additional support point, and may be desirable when, for example, the support structure 102 is storing thin wafers.", "Unlike the storage shelves in a conventional container, the tine 106 supports a wafer, yet enables access to the wafer's perimeter P located between the two support pads 108 and 110.FIG.", "2A shows that the wafer's perimeter P, and an area 120 of the wafer W, extend out beyond the tine 106 between the support pads 108 and 110.The area 120 of the wafer W that extends beyond, or overhangs, the tine 106 is referred to as a “grip zone.” The grip zone 120 provides an access area for an end effector or other mechanical apparatus to contact or grip the wafer W while the wafer W is seated on the pair of tines 106.The grip zone 120 is created because the distance d1 between the pair of tines (e.g., tines 106a1 and 106a2) is less than the diameter D of the wafer W. Thus, each tine 106 passes under the wafer W. Accessing wafers stored in a FOUP or SMIF pod with a conventional end effector requires many complicated, precise movements.", "First, the end effector is inserted into the FOUP storage area to a predetermined position that aligns the end effector with the wafer it is going to remove from the FOUP.", "To get to this predetermined position, the end effector travels between adjacent wafers (e.g., wafers W1 and W2 in FIG.", "2B) towards the back of the FOUP.", "The entire time, the end effector is within millimeters of the wafer surface.", "The end effector then rises up; contacting the bottom surface of the wafer, and proceeds to raise up until the wafer is lifted completely from the shelf.", "The end effector, with a wafer seated upon it, is then removed from the container without contacting either of two adjacent shelves or the adjacent wafer.", "The end effector operates within this narrow area (e.g., between the two adjacent shelves) the entire time, and must not damage the wafer (e.g., contacting either shelf).", "A conventional end effector must travel within this narrow area between adjacent wafers twice when the end effector drops off a wafer in the FOUP and then immediately travels to another wafer within the FOUP.", "For example, to drop off a wafer within the FOUP, the end effector travels into the FOUP and lowers the wafer onto a storage shelf.", "The end effector then retracts out of the FOUP; traveling out of the FOUP between two adjacent wafers.", "Once the end effector clears the wafers, the end effector shifts in a vertical direction and is inserted between two different adjacent wafers.", "The end effector then repeats the same movements to remove the new wafer from the FOUP.", "The end effector may accidentally strike or contact a wafer and damage the wafer while traveling between the wafers.", "If the support structures 102 are located in a container (e.g., a FOUP), the present disclosure eliminates the need for an end effector to travel across the entire face of the wafer simply to position its support pads under the wafer.", "At the very least, the end effector has to travel across only a very small portion of each wafer to position its support pads.", "By creating the “grip zones” 120, an end effector may travel vertically within the FOUP enclosure along the outside of the wafer's perimeter or peripheral edge.", "When, for example, an end effector reaches the appropriate height to engage a wafer, the end effector arms only have to move a small distance towards the wafer until the end effector's support pads are positioned to support the wafer and lift the wafer off the storage shelf.", "The end effector does not have to travel across the entire face of the wafer to lift the wafer off the support shelf.", "FIGS.", "2A and 4 illustrate one embodiment of an end effector 200.An end effector may comprise any structure that acquires, supports and transports a wafer or any other article (e.g., reticle, FPD, etc.", "), and is conventionally driven by, or attached to, a robotic mechanism (e.g., robotic arm).", "An end effector may passively acquire a wafer (e.g., end effector include tines) or actively acquire a wafer (e.g., end effector includes a gripper mechanism that moves between a wafer loading position and a wafer contact position).", "In this embodiment, the end effector 200 includes a first arm 202 and a second arm 204.The first arm 202 includes a first support pad 210 and second support pad 212.The second arm 204 includes a first support pad 214 and second support pad 216.In a preferred embodiment, three or more support pads support a wafer.", "For example, the first arm 202 may have two supports pads and the second arm 204 may have one support pad, or vice versa.", "The first and second support pads 210 and 212 on the first arm 202, and the first and second support pads 214 and 216 on the second arm 204, are spaced apart from each other.", "It is within the scope of the present disclosure for the end effector 200 to include two or more support pads shared between the two arms 202 and 204.The first and second support pads 210 and 212 on the first arm 202, and the first and second support pads 214 and 216 on the second arm 204, may be passive supports or active supports.", "If the supports are passive, the support pads 210-216 remain in the position shown in FIG.", "4 at all times.", "In this case, a wafer W remains on the support pads 210-216 by gravitational forces.", "If the support pads 210-216 are active supports, at least one support, and preferably each support, moves between a wafer loading position and a wafer gripping position.", "The wafer loading position allows the wafer to be seated on the end effector.", "After the wafer is seated on the end effector, the support pads moves towards the center of the wafer until the support pads contact the peripheral edge of the wafer.", "The configuration of the end effector 200 and the arms 202 and 204 shown in FIGS.", "2A and 4 are only for illustration purposes.", "The end effector 200 may have other configurations and the arms 202 and 204 may, for example, include only one support pad each or incorporate a break-the-beam sensor system 230.A break-the-beam sensor is known within the semiconductor manufacturing art and is often used to accurately map the true position of each wafer stored in the container to provide error-free, scrape-free placement and retrieval of wafers at random access positions.", "Such a sensor system is well known within the art and therefore does not require further disclosure herein.", "In effect, the conventional end effector blade is eliminated; the end effector does not travel within the interstitial spaces between wafers.", "The arms 202 and 204 of the end effector structure may have any reasonable thickness as required for minimizing deflection and controlling vibration.", "The support pads 210 and 212 on the first arm 202 and the support pads 214 and 216 on the second arm 204 may be passive retention/support surfaces or activated retention surfaces with motion in the direction 232.If the end effector arms 202 and 204 cannot move in the direction 232, the end effector 200 first travels in the direction 234 beneath the wafer until the support pads 210, 212, 214 and 216 are located substantially underneath the wafer's “grip zone” 120.The end effector 200 then moves vertically (e.g., direction 236 in FIG.", "2B) to engage the bottom surface 20 of the wafer W and lift the wafer W a controlled amount off the storage shelf.", "The end effector 200 can then withdraw the wafer W from the container.", "If the end effector 200 has arms 202 and 204 that move in the direction 232, the end effector 200 can freely travel in the vertical direction 236 unimpeded by the presence or absence of wafers stored in the container.", "In this case, the distance between the arms 202 and 204, while each are located in a retracted position, must be greater than the diameter D of each wafer stored in the container.", "In operation, the end effector 200 travels first in the direction 234 until the supports of each arm 202 and 204 are substantially vertically aligned with the “grip zone” 120 of a wafer stored in the container.", "The end effector 200 travels in the vertical direction 236 until the arms 202 and 204 are located at a desired wafer level.", "The arms 202 and 204 extend towards the wafer until the support pads 210, 212, 214 and 216 are located substantially in the positions shown in FIG.", "1A.", "The end effector 200 moves upward in the vertical direction 236, lifting the wafer W off the tines 106 prior to removing the wafer W from the container in the direction 234.FIG.", "3 illustrates the end effector 200 shown in FIG.", "2A in operation with a wafer chuck 50.The wafer chuck 50 illustrates that other semiconductor devices may accommodate the end effector 200.In particular, the wafer chuck 50 includes four relief channels 52, 54, 56 and 58.Each relief channel is aligned such that the end effector 200 may lower the wafer W onto the chuck 50 and no contact the wafer chuck 50.Once the wafer W is seated on the chuck 50, the end effector arms 202 and 204 move laterally away from the chuck 50 in the direction 232 and then retracts from the chuck 50 in the direction 234.FIGS.", "4-8 illustrate various embodiments of an end effector.", "FIG.", "4 illustrates one embodiment of an end effector 200 with passive fingers.", "The end effector 200 includes a body 201 having a first arm 202 and a second arm 204.The first and second arms 202 and 204 are shown in FIG.", "4 as curved structures.", "The body 201 and arms 202 and 204 may have different shapes.", "The support pads 210, 212, 214 and 216 are each shown having a flat contact surface 218 for contacting the bottom surface of the wafer and a backstop surface 220 that, in effect, prevents the wafer from sliding off the contact surface 218.Each support pad may have different shaped contact surfaces that minimize the amount of contact between the contact surface 218 and the wafer.", "The end effector 200 is shown having an optional third finger 220 to provide additional support.", "The third finger 222 includes a wafer contact surface 224.In operation, the end effector 200 is positioned such that, when the end effector 200 moves towards the wafer in direction 234, the fingers 202 and 204 move under the grip zone 120 of the wafer to be removed from the container.", "The end effector 200 moves forward until the contact surfaces 218 of the support pads 210, 212, 214 and 216 are located in substantially the position shown in FIG.", "2A.", "At this point, the end effector 200 moves upward until the wafer is initially seated on the contact surfaces 218, and continues to move upward until the wafer is raised off the storage shelf (e.g., pair of tines 106).", "The end effector 200 then retracts in the direction 234 until the wafer is removed from the container.", "FIG.", "5 illustrates another embodiment of an end effector 300.The end effector 300 includes a first arm 302 and a second arm 304.The first arm 302 has a first support pad 310 and a second support pad 312.The second arm 304 has a first support pad 314 and a second support pad 316.The end effector 300 may also include a third arm 317 having a support pad 315, which provides additional support.", "FIG.", "5 illustrates that each arm is pinned to the end effector body 301.The first arm 302 pivots with respect to the end effector body 301 about a pivot pin 320.The second arm 304 pivots with respect to the end effector body 301 about a pivot pin 322.Each arm may be affixed to the end effector body 301 by other mechanical devices that allow the arms to rotate with respect the end effector body 301.In this embodiment, the first arm 302 is rotated about pivot pin 320 by an actuator 324, while the second arm 304 is rotated about the pivot pin 322 by an actuator 326.FIG.", "5 illustrates that the first arm 302 moves between a retracted position A and a workpiece support position B.", "The second arm 304 also moves between a retracted and workpiece support position.", "With the first and second arms 302 and 304 each in a retracted position (e.g., position A), the end effector 300 may travel vertically within the container enclosure between wafers because the arms 302 and 304 move between the outer edge 107 of each tine 106 and the interior of the container wall.", "Thus, the end effector 300 moves vertically between wafers in the direction 236 without having to move in the direction 234 at all—reducing the travel time between wafers.", "In operation, the end effector 300 stops at a wafer “pick” location.", "The arms 302 and 304 move to position B, which places the support pads 310, 312, 314 and 316 underneath the wafer.", "The end effector 300 rises until the wafer is seated on the support pads, and continues to rise to lift the wafer off the storage shelf.", "The end effector 300 then retracts and removes the wafer out of the container enclosure 28.FIG.", "6 illustrates another embodiment of an end effector 400.The end effector 400 includes a body 401 having a first arm 402 and a second arm 404.The first and second arms 402 and 404 are shown in FIG.", "6 as curved structures.", "The arms 402 and 404 may have different shapes.", "The support pads 410, 412, 414 and 416 are each shown as a cylindrical actuator having a slot 415.The support pads 410-416 may have other shapes.", "The end effector 400 is shown having an optional third finger 420 with a support pad 424 for additional support.", "In operation, the end effector 400 moves along directions 434 and 436 until the support pads 410-416 are positioned adjacent a wafer W. At this point, the support 410-416 move in the direction R1 towards the wafer W until each support pad contacts the peripheral edge of the wafer W and effectively grips the wafer.", "In this embodiment, the wafer's peripheral edge P fits into the slot 415 of each support pad.", "The end effector 400 then moves upward along direction 436 to raise the wafer W off the storage shelf.", "The end effector 400 then retracts in the direction 434 until the wafer is removed from the container enclosure.", "FIG.", "7 illustrates another embodiment of an end effector 500.The end effector 500 includes a first arm 502 and a second arm 504.The first arm 502 has a first support pad 510 and a second support pad 512.The second arm 504 has a first support pad 514 and a second support pad 516.FIG.", "7 illustrates that each arm is pinned to the end effector body 501.The first arm 502 pivots with respect to the end effector body 501 about a pivot pin 520.The second arm 504 pivots with respect to the end effector body 501 about a pivot pin 522.Each arm may be affixed to the body 501 by other mechanical devices that allow the arms to rotate with respect the end effector body 501.The first arm 502 moves between a retracted position A and a workpiece support position B.", "The second arm 504 also moves between a retracted position A and workpiece support position B (not shown).", "FIG.", "8 illustrates an end effector 600.In this embodiment, the end effector 600 is capable of rotating a wafer seated on the end effector 600 about the wafer's center.", "The end effector 600 includes a first arm 602 and a second arm 604.The first arm 602 includes a first support pad 610 and a second support pad 612.The second arm 604 includes a first support pad 614 and a second support pad 616.Each support pad, in this embodiment, comprises a rotatable support mechanism for rotating a wafer seated on the end effector 600.In this embodiment, the first arm 602 is rotatably attached to the end effector body 601 by a pin 620.The second arm 604 is rotatably attached to the end effector body 601 by a pin 622.A first actuator 624 rotates the first arm 602 about the pin 620.A second actuator 626 rotates the second arm 604 about the second pin 622.Thus, the first and second arms 602 and 604 rotate between position A and position B.", "The arms 602 and 604 may be rotatably secured to the body 601 in other manners.", "It is often necessary to rotate the wafer W about its vertical centerline axis to read, for example, identification codes or to align the geometrical fiducials, including notches, in the wafer perimeter P. The end effector 600 shown in FIG.", "8 is only an exemplary embodiment of an end effector with rotatable support pads 610, 612, 614 and 616 for rotating the wafer W on the end effector 600.Likewise, the mechanism used for reading identifying marks on the top or bottom surfaces of the wafer perimeter can be enabled by utilizing an imaging device (camera) or other reading means mounted on the end effector.", "Accomplishing this “in-situ” saves time and floor space, and reduces cost and mechanism complexity.", "The various embodiments of the end effectors described herein allow the arms of the end effector to move vertically external to the wafer's peripheral edge P. Thus, almost all of the wafer support surface of a process or metrology tool chuck may be used to support the wafer and does not need, in large part, to accommodate the end effector blade (e.g., arms and body).", "FIG.", "3 illustrates one embodiment of a metrology or process tool chuck 50 in operation with the end effector 200.In this embodiment, the chuck 50 includes a body 62 having a wafer support surface 51, four indentations or channels to accommodate each support pad, a first slot 60 and a second slot 63.FIG.", "3 illustrates a wafer W seated directly on the surface 51.It is also within the scope of the invention to have lift pins, or other support structures, extending from the surface 51 for supporting the wafer W above the surface 51.The wafer W may be secured on the support surface 51 (or other support structure) by any method known in the art including, but not limited to, vacuum, gravity or electrostatic attraction.", "To accommodate the arms 202 and 204 of the end effector 200, the chuck body 62 includes a recessed area or channel to allow each arm to pass through the chuck body 62 after the end effector 200 places the wafer on the surface 51.For example, the chuck body 62 includes a recessed surface 52 to allow the support pad 214 pass through the chuck body 62, a recessed surface 54 to allow the support pad 216 pass through the chuck body 62, a recessed surface 56 to allow the support pad 212 pass through the chuck body 62, and a recessed surface 58 to allow the support pad 210 pass through the chuck body 62.In operation, the end effector 200 places the wafer W on the surface 51 and keeps traveling vertically downward into the chuck body 62.The end effector must retract from the chuck 50 to allow the chuck to spin the wafer W. If the arms 202 and 204 cannot move away from the chuck body 62 in the direction 232, the end effector would not be able to retract from the chuck 50 in the direction 234.In one embodiment, each recessed surface travels completely through the chuck body 62 such that the end effector may effectively pass through the bottom surface of the chuck body 62 and then retract in the direction 234 away from the chuck 50.Alternately, the chuck body 62 includes a first horizontal slot 60 and a second horizontal slot 63 each located at a predetermined elevation below the surface 51.The slots allows the end effector to lower the arms 202 and 204 to an elevation aligned with the slots 60 and 63, and subsequently retract in the direction 234 away from the chuck 50 through the slots 60 and 63.Arm 202 passes through the chuck body 62 within the slot 60 and the arm 204 passes through the chuck body 62 within the slot 63.If the end effector 200 includes a third arm 222 (as shown in FIG.", "3), the chuck body 62 includes a fifth recessed surface 65 to accommodate the third arm 222.In operation after the end effector 200 places the wafer W on the surface 51 the end effector continues to travel vertical downward and the arm 222 will pass through the body 62 within the recessed surface 65.Each recessed surface in the chuck body 62 takes away a small amount of the support surface 51.However, the reduction in the support surface 51 due to the recessed surfaces is minimal.", "In semiconductor processing, wafers often have a starting thickness of 0.7 mm-1.0 mm.", "The wafers are then thinned to a thickness of less than 0.3 mm at some intermediate stage of the total manufacturing process sequence.", "The thinned wafer is very flexible and fragile, and the historical methods of wafer edge support in a container as well as the conventional edge gripping methods, are not adequate.", "Each storage shelf supports a wafer at multiple points.", "In particular, each storage shelf preferably supports a wafer by at least three contact points or support pads.", "In one embodiment, a storage shelf, which comprises two tines 106, includes a single support pad on each tine 106 (e.g., support pad 110) and a support pad located on each base member 104 (e.g., support pad 108)—all at substantially the same elevation in order to support a wafer in a horizontal orientation.", "In another embodiment, each tine 106 includes an additional support pad (e.g., support pad 116) to provide additional support.", "Of course, each tine 106 and/or base member 104 may include additional support pads.", "The number and geometry of additional support pads for both the end effector and the storage shelves is limited only by the requirement for the end effector to interact with each tine 106.FIG.", "9 illustrates one embodiment of a wafer support structure 202 within a conventional FOUP 10.The FOUP 10 includes a housing or shell 12 and a FOUP door 14 that mechanically couples with the FOUP shell 12.The housing 12, which includes a top 18, a back 20, a first side 22, a second side 24 and a bottom 26, defines an enclosure 28.In this embodiment, the support structures 202 are affixed to the top 18 and bottom 26 of the FOUP shell 12.For example, the top end 203 of each support structure 202 is affixed to the top 18 of the FOUP shell 12 by three fixtures 205.The bottom end (not shown) of the support structure 202 is fixed to the bottom 26 of the FOUP shell 12.It is also within the scope of the present disclosure for the support structures 202 to be affixed to either the top 18 or the bottom 26 of the FOUP shell 12, or be affixed to the FOUP shell 12 by other methods.", "Each support structure 202 may also be molded with the FOUP shell 12.For example, each base member 204 may be molded into the back 20 of the FOUP shell 12, or any of the other surfaces of the FOUP shell 12 (e.g., top 18, bottom 26, first side 22, second side 24, etc.).", "In another embodiment, the support structure 202 may not include a base member 204.Instead, each storage shelf comprises one or more tines 206; each affixed or molded into the FOUP shell 12.For example, the proximal end 214 of each tine 206 may include a pair of tabs that lock into a pair of slots located in the back 20 of the FOUP shell 12.FIG.", "9 illustrates that the two support structures 202 comprise two separate structures.", "However, any portion of the support structures 202, such as the base members 204 and/or tines 206, may comprise a single piece of material.", "FIG.", "9 illustrates one embodiment of a storage shelf, comprising a pair of tines 206, for exemplary purposes.", "Each tine 206 extends or projects from the base member 204.The tine 206 includes a first end or proximal end 214 and a second end or distal end 216.The combination of the two tines 206 and the base members 204 support a single wafer W with six support pads—two support pads 208, two support pads 210 and two support pads 212.The support pad 210 is located at or near the distal end 216 of each tine 206.The other four support pads 208 and 212 may be located on either the proximal end 214 of the tine 206 or the base members 204, or a combination of the two.", "It is within the scope of the present disclosure for other portions of the tine 206 to contact the wafer W or for the support pads to be located in other positions.", "FIG.", "9 illustrates that the wafer's peripheral edge P, and a portion of the wafer W, overhangs or extends beyond the outer edge 207 of each tine 206 between the support pads 210 and 212—while the wafer W is seated on the storage shelf.", "As discussed above, this overhanging portion of the wafer W is referred to as the “grip” or “access” area that may be engaged by an end effector while the wafer W is seated in the FOUP 10.FIG.", "10 illustrates an end effector 700 inserted into the FOUP 10.The end effector 700 includes a body 701, a first arm 702 and a second arm 704.The body 701 may be connected to, by way of example only, a robotic arm for moving the end effector body 701 through any number of movements (e.g., six degrees of freedom motion).", "The first arm 702 has a proximal end 706 and a distal end 708.The second arm 704 includes a proximal end 707 and a distal end 709.The FIG.", "10 embodiment of the end effector 700 includes two support pads on each arm.", "The first arm 702 includes a support pad 710 located a the proximal end 706 and a second support pad 712 located at the distal end 708.The second arm 704 includes a support pad 714 located the proximal end 707 and a support pad 716 located at the distal end 709.Each arm may include any number of support pads, and each support pad may be located anywhere along the end effector's arms.", "It is preferable that the support pads do not interfere with the support structure 202.FIG.", "10 illustrates each support pad 710-716 as a passive pad.", "Alternately, each support pad 710-716 may comprise an active pad similar to the end effector embodiments shown in FIGS.", "4-8.When the end effector 700 is placed into the FOUP enclosure 28, the arms 702 and 704 contour around the wafer's peripheral edge P—as shown in FIG.", "10.In a preferred embodiment, the distance between the wafer's peripheral edge P and each side of the FOUP shell 12, such as the first side 22 and the second side 24, is large enough so that the arms 702 and 704 of the end effector 700 may travel vertically within the enclosure 28 without contacting any part of the support structure 202 or the wafer W or the FOUP shell 12.It is also within the scope of the present disclosure for this distance to be minimal (as shown in FIG.", "10) such that arms 702 and 704 of the end effector 700 may not travel vertically within the enclosure 28 without contacting any part of the support structure 202 or the wafer W. Thus, after setting a wafer on a storage shelf, the end effector 700 would have to travel out of the enclosure, and raise/lower to another elevation before the end effector 700 can be inserted back into the enclosure 28.Unlike a conventional end effector, the arms 702 and 704 preferably do not travel under a wafer in order to place the contact pads 710-716 under a wafer or lift a wafer from a storage shelf.", "Maintaining the arms 702 and 704 on the outside of the wafer W eliminates the possibility that either of the arms 702 or 704 will contact and/or damage the surface of a wafer seated in the FOUP 10.The shape of the arms 702 and 704 shown in FIG.", "10 is for exemplary purposes only.", "The arms 702 and 704 may comprise other shapes and/or configurations.", "The arms 702 and 704 of the end effector 700 also preferably contour around each tine 206.If the support pads 710-716 are active pads (e.g., able to move towards/away from the wafer's peripheral edge P), the end effector 700 may be placed into the FOUP enclosure 28 at any height and subsequently move vertically to another elevation within the FOUP 10 without having to first withdraw from the FOUP enclosure 28.With the support pads retracted, the end effector 700 may travel to its desired position.", "Once the end effector 700 reaches a desired location, the support pads 710-716 extend towards the wafer until a portion of each support pad 710-716 is located below the wafer W. This way, the wafer W will be supported (preferably in a horizontal orientation) when the end effector 700 lifts the wafer W off the tines 206 or storage shelf and removes the wafer W from the FOUP 10.It should be appreciated that the above-described tine systems and end effectors are for explanatory purposes only and that the invention is not limited thereby.", "Having thus described a preferred embodiment of a tine system and end effector, it should be apparent to those skilled in the art that certain advantages of the within system have been achieved.", "It should also be appreciated that various modifications, adaptations, and alternative embodiments thereof may be made within the scope and spirit of the present disclosure.", "For example, the storage shelves and end effector have been illustrated in a semiconductor fabrication facility, but it should be apparent that many of the inventive concepts described above would be equally applicable to be used in connection with other non-semiconductor manufacturing applications.", "It should be apparent that the storage shelves are also not limited to workpiece carriers." ] ]
Patent_15875890
[ [ "CHIMERIC INFECTIOUS DNA CLONES, CHIMERIC PORCINE CIRCOVIRUSES AND USES THEREOF", "The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2.", "The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position.", "The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2.", "The invention further embraces the immunogenic polypeptide expression products.", "In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones." ], [ "1.A recombinant porcine circovirus type 1 encoding the ORF2 capsid protein of a porcine circovirus type 2 (PCV1-2).", "2.The PCV1-2 virus according to claim 1, wherein the PCV1-2 virus is made from a nucleotide sequence having at least 95% homology to the nucleotide sequence of SEQ ID NO: 2.3.The PCV1-2 virus according to claim 2, wherein the PCV1-2 virus is made from a nucleotide sequence set forth in SEQ ID NO: 2 or its complementary strand.", "4.The PCV1-2 virus according to claim 1, wherein the PCV1-2 virus is inactivated.", "5.An inactivated vaccine for use in immunizing pigs against PCV2 infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2, wherein the vaccine comprises the inactivated PCV1-2 virus according to claim 4.6.The vaccine according to claim 5, further comprising an adjuvant.", "7.The vaccine according to claim 5, further comprising a suspending agent or an emulsifying agent.", "8.The vaccine according to claim 5, further comprising at least one additional porcine antigen.", "9.The vaccine according to claim 8, wherein the additional porcine antigen is an infectious swine agent.", "10.The vaccine according to claim 5, wherein the inactivated PCV1-2 virus is suspended in a physiologically acceptable carrier or solvent system.", "11.The vaccine according to claim 5, further comprising a preservative.", "12.A method of immunizing a pig against PCV2 infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2, comprising administering to the pig an immunologically effective amount of the vaccine according to claim 5.13.The method according to claim 12, which comprises administering the vaccine in a single dose or in repeated doses.", "14.The method according to claim 13, which comprises administering the vaccine in a single dose.", "15.The method according to claim 12, which comprises administering the vaccine intranasally, transdermally, or parenterally.", "16.The method according to claim 15, wherein the parenterally administered vaccine is administered intramuscularly, intravenously, intraperitoneally, or intradermally.", "17.The method according to claim 16, which comprises administering the vaccine intramuscularly.", "18.A method of preparing a vaccine according to claim 5, comprising the steps of: (a) replacing the ORF2 gene in the genome of PCV1 with the ORF2 gene of PCV2 to form an infectious chimeric nucleic acid molecule of PCV1-2; (b) infecting cells with the infectious chimeric nucleic acid molecule of step (a) to produce live recombinant PCV1-2 virus expressing the ORF2 capsid protein of PCV2; and (c) inactivating the live recombinant PCV1-2 virus of step (b).", "19.The method according to claim 18, wherein step (c) comprises inactivating the live recombinant PCV1-2 virus with an inactivating agent.", "20.The method according to claim 19, further comprising step (d) adding a suspending agent to form a suspension of the inactivated PCV1-2 virus and step (e) combining the suspension with an adjuvant, at least one additional porcine antigen or both an adjuvant and at least one additional porcine antigen.", "21.The method according to claim 20, wherein the additional porcine antigen is an infectious swine agent." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> BRIEF SUMMARY OF THE INVENTION <EOH>The present invention concerns infectious chimeric DNA clones of porcine circovirus (PCV) and live chimeric viruses derived from the DNA clones that are useful as vaccines.", "The new live chimeric, genetically avirulent viruses are made from the nonpathogenic PCV1 genomic structure in which an immunogenic gene of a pathogenic PCV2 strain replaces a gene of the PCV1, typically in the same corresponding position.", "The invention encompasses the biologically functional plasmids, viral vectors and the like that contain the new recombinant nucleic acid molecules described herein, suitable host cells transfected by the vectors comprising the DNA and the immunogenic polypeptide expression products.", "Included within the scope of the present invention is a novel method of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2 comprising administering to a pig in need of such protection an immunologically effective amount of a vaccine comprising, for example, the cloned chimeric DNA in a plasmid, a chimeric virus derived from the chimeric DNA clone, the polypeptide products expressed from the DNA described herein, etc.", "A further embodiment of the invention is drawn to novel mutants of the PCV2 immunogenic capsid gene and protein, and the introduction of the mutations in the chimeric clones to facilitate cell culture growth and ensure vaccine safety.", "The invention also provides new infectious PCV2 molecular DNA and reciprocal chimeric DNA clones of PCV that find use as experimental models in obtaining or characterizing the novel avirulent viral vaccines." ], [ "CROSS-REFERENCE TO RELATED U.S.", "APPLICATIONS This application is a continuation of co-pending U.S. application Ser.", "No.", "14/940,799, filed on Nov. 13, 2015, allowed, which is a continuation of U.S. application Ser.", "No.", "13/268,008, filed on Oct. 7, 2011, now U.S. Pat.", "No.", "9,211,324, which is a continuation of U.S. application Ser.", "No.", "12/539,540, filed on Aug. 11, 2009, now U.S. Pat.", "No.", "8,058,048, which is a division of U.S. application Ser.", "No.", "11/893,182, filed on Aug. 15, 2007, now U.S. Pat.", "No.", "7,575,752, which is a division of U.S. application Ser.", "No.", "10/808,964, filed on Mar.", "25, 2004, now U.S. Pat.", "No.", "7,279,166, which, in turn, is a continuation-in-part application which claims the benefit under 35 U.S.C.", "§ 120 of the prior, nonprovisional U.S. application Ser.", "No.", "10/314,512, filed on Dec. 9, 2002, now U.S. Pat.", "No.", "7,276,353, which claims the benefit under 35 U.S.C.", "§ 119(e) of U.S.", "Provisional Application No.", "60/424,840, filed on Nov. 8, 2002, abandoned, which claims the benefit under 35 U.S.C.", "§ 119(e) of U.S.", "Provisional Application No.", "60/340,775, filed on Dec. 12, 2001, abandoned.", "All prior applications are incorporated herein by reference in their entirety.", "STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This study was supported in part by a grant from the U.S. Department of Agriculture National Research Initiative Competitive Grant Program (NRI 2004-35204-14213).", "REFERENCE TO A “Sequence Listing” The material on a single compact disc containing a Sequence Listing file provided in the prior nonprovisional application is incorporated by reference.", "The date of creation is Jan. 22, 2003 and the size is approximately 9.5 kb.", "BACKGROUND OF THE INVENTION Field of the Invention The present invention concerns infectious porcine circovirus type-1 (PCV1) and type-2 (PCV2) DNA clones, chimeric PCV1-2 infectious DNA clones and live chimeric viruses derived from the chimeric DNA clones, useful as vaccines.", "The invention further concerns two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.", "Description of the Related Art All patents and publications cited in this specification are hereby incorporated by reference in their entirety.", "Porcine circovirus (PCV) was originally isolated as a noncytopathic cell culture contaminant of a porcine kidney cell line PK-15 (I. Tischer et al., “A very small porcine virus with circular single-stranded DNA,” Nature 295:64-66 (1982); I. Tischer et al., “Characterization of papovavirus and picornavirus-like particles in permanent pig kidney cell lines,” Zentralbl.", "Bakteriol.", "Hyg.", "Otg.", "A.", "226(2):153-167 (1974)).", "PCV is a small icosahedral non-enveloped virus that contains a single stranded circular DNA genome of about 1.76 kb.", "PCV is classified in the family of Circoviridae along with other animal circoviruses such as chicken anemia virus (CAV), Psittacine beak and feather disease virus (PBFDV) and tentative members columbid circovirus (CoCV) discovered in pigeons, goose circovirus and canary circovirus, and three plant circoviruses (banana bunchy top virus, coconut foliar decay virus and subterranean clover stunt virus) (K. V. Phenix et al., “Nucleotide sequence analysis of a novel circovirus of canaries and its relationship to other members of the genus circovirus of the family Circoviridae,” J. Gen. Virol.", "82:2805-2809 (2001); Todd et al., “Genome sequence determinations and analyses of novel circoviruses from goose and pigeon,” Virology 286:354-362 (2001); M. R. Bassami et al., “Psittacine beak and feather disease virus nucleotide sequence analysis and its relationship to porcine circovirus, plant circoviruses, and chicken anemia virus,” Virology 249:453-459 (1998); J. Mankertz et al., “Transcription analysis of porcine circovirus (PCV),” Virus Genes 16:267-276 (1998); A. Mankertz et al., “Cloning and sequencing of columbid circovirus (CoCV), a new circovirus from pigeons,” Arch.", "Virol.", "145:2469-2479 (2000); B. M. Meehan et al., “Sequence of porcine circovirus DNA: affinities with plant circoviruses,” J. Gen. Virol.", "78:221-227 (1997); B. M. Meehan et al., “Characterization of novel circovirus DNAs associated with wasting syndromes in pigs,” J. Gen. Virol.", "79:2171-2179 (1998); D. Todd et al., “Comparison of three animal viruses with circular single-stranded DNA genomes,” Arch.", "Virol.", "117:129-135 (1991)).", "Members of the three previously recognized animal circoviruses (PCV, CAV, and PBFDV) do not share nucleotide sequence homology or antigenic determinants with each other (M. R. Bassami et al., 1998, supra; D. Todd et al., 1991, supra).", "The genome of the newly identified CoCV shared about 40% nucleotide sequence identity with that of PCV (A. Mankertz et al., “Cloning and sequencing of columbid circovirus (CoCV), a new circovirus from pigeons,” Arch.", "Virol.", "145:2469-2479 (2000)).", "Recently, a novel human circovirus with a circular genome, designated as transfusion transmitted virus or TT virus (TTV), was identified from individuals associated with post-transfusion hepatitis (H. Miyata et al., “Identification of a novel GC-rich 113-nucleotide region to complete the circular, single-stranded DNA genome of TT virus, the first human circovirus,” J. Virol.", "73:3582-3586 (1999); T. Nishizawa et al., “A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology,” Biochem.", "Biophys.", "Res.", "Commun.", "241:92-97 (1997)).", "Additionally, a human TTV-like mini virus (TLMV) was identified from normal blood donors (P. Biagini et al., “Genetic analysis of full-length genomes and subgenomic sequences of TT virus-like mini virus human isolates,” J. Gen. Virol.", "82: 379-383 (2001); K. Takahashi et al., “Identification of a new human DNA virus (TTV-like mini virus, TLMV) intermediately related to TT virus and chicken anemia virus,” Arch.", "Virol.", "145:979-93 (2000)) and a third novel human circovirus, known as SEN virus (SENV), was also discovered from humans with post-transfusion hepatitis (T. Umemura et al., “SEN virus infection and its relationship to transfusion-associated hepatitis,” Hepathology 33:1303-1311 (2001)).", "The genomic organization of both human TTV and TLMV is similar to that of the CAV (P. Biagini et al., 2001, supra; H. Miyata et al., 1999, supra; K. Takahashi et al., 2000, supra).", "Although antibodies to PCV were found in various animal species including humans, mice, cattle and pigs (G. M. Allan et al., “Production, preliminary characterization and applications of monoclonal antibodies to porcine circovirus,” Vet.", "Immunol.", "Immunopathol.", "43:357-371 (1994); G. C. Dulac and A. Afshar, “Porcine circovirus antigens in PK-15 cell line (ATCC CCL-33) and evidence of antibodies to circovirus in Canadian pigs,” Can.", "J. Vet.", "Res.", "53:431-433 (1989); S. Edwards and J. J. Sands, “Evidence of circovirus infection in British pigs,” Vet.", "Rec.", "134:680-1 (1994); J. C. Harding and E. G. Clark, “Recognizing and diagnosing postweaning multisystemic wasting syndrome (PMWS),” Swine Health and Production 5:201-203 (1997); R. K. Hines and P. D. Lukert, “Porcine circovirus: a serological survey of swine in the United States,” Swine Health and Production 3:71-73 (1995); G. P. Nayar et al., “Evidence for circovirus in cattle with respiratory disease and from aborted bovine fetuses,” Can.", "Vet.", "J.", "40:277-278 (1999); I. Tischer et al., “Distribution of antibodies to porcine circovirus in swine populations of different breeding farms,” Arch.", "Virol.", "140:737-743 (1995); I. Tischer et al., “Presence of antibodies reacting with porcine circovirus in sera of humans, mice, and cattle,” Arch.", "Virol.", "140:1427-1439 (1995)), little is known regarding the pathogenesis of PCV in these animal species.", "Experimental infection of pigs with the PK-15 cells-derived PCV did not produce clinical disease and thus, this virus is not considered to be pathogenic to pigs (G. M. Allan et al., “Pathogenesis of porcine circovirus; experimental infections of colostrum deprived piglets and examination of pig foetal material,” Vet.", "Microbiol.", "44:49-64 (1995); I. Tischer et al., “Studies on epidemiology and pathogenicity of porcine circovirus,” Arch.", "Virol.", "91:271-276 (1986)).", "The nonpathogenic PCV derived from the contaminated PK-15 cell line was designated as porcine circovirus type 1 or PCV1.Postweaning multisystemic wasting syndrome (PMWS), first described in 1991 (J. C. Harding and E. G. Clark, 1997, supra), is a complex disease of weaning piglets that is becoming increasingly more widespread.", "With the threat of a potential serious economic impact upon the swine industry, it has become urgent to develop a vaccine against PCV2, the primary causative agent of PMWS.", "PMWS mainly affects pigs between 5-18 weeks of age.", "Clinical PMWS signs include progressive weight loss, dyspnea, tachypnea, anemia, diarrhea, and jaundice.", "Mortality rate may vary from 1% to 2%, and up to 40% in some complicated cases in the U.K. (M. Muirhead, “Sources of information on PMWS/PDNS,” Vet.", "Rec.", "150:456 (2002)).", "Microscopic lesions characteristic of PMWS include granulomatous interstitial pneumonia, lymphadenopathy, hepatitis, and nephritis (G. M. Allan and J.", "A. Ellis, “Porcine circoviruses: a review,” J. Vet.", "Diagn.", "Invest.", "12:3-14 (2000); J. C. Harding and E. G. Clark, 1997, supra).", "PMWS has now been recognized in pigs in Canada, the United States (G. M. Allan et al., “Novel porcine circoviruses from pigs with wasting disease syndromes,” Vet.", "Rec.", "142:467-468 (1998); G. M. Allan et al., “Isolation of porcine circovirus-like viruses from pigs with a wasting disease in the USA and Europe,” J. Vet.", "Diagn.", "Invest.", "10:3-10 (1998); G. M. Allan and J.", "A. Ellis, 2000, supra; J. Ellis et al., “Isolation of circovirus from lesions of pigs with postweaning multisystemic wasting syndrome,” Can.", "Vet.", "J.", "39:44-51 (1998); A. L. Hamel et al., “Nucleotide sequence of porcine circovirus associated with postweaning multisystemic wasting syndrome in pigs,” J. Virol.", "72:5262-5267 (1998); M. Kiupel et al., “Circovirus-like viral associated disease in weaned pigs in Indiana,” Vet.", "Pathol.", "35:303-307 (1998); R. Larochelle et al., “Identification and incidence of porcine circovirus in routine field cases in Quebec as determined by PCR,” Vet.", "Rec.", "145:140-142 (1999); B. M. Meehan et al., 1998, supra; I. Morozov et al., “Detection of a novel strain of porcine circovirus in pigs with postweaning multisystemic wasting syndrome,” J. Clin.", "Microbiol.", "36:2535-2541 (1998)), most European countries (G. M. Allan et al., “Isolation of porcine circovirus-like viruses from pigs with a wasting disease in the USA and Europe,” J. Vet.", "Diagn.", "Invest.", "10:3-10 (1998); G. M. Allan and J.", "A. Ellis, 2000, supra; S. Edwards and J. J. Sands, 1994, supra; S. Kennedy et al., “Porcine circovirus infection in Northern Ireland,” Vet.", "Rec.", "142:495-496 (1998); A. Mankertz et al., “Characterization of PCV-2 isolates from Spain, Germany and France,” Virus Res.", "66:65-77 (2000); C. Rosell et al., “Identification of porcine circovirus in tissues of pigs with porcine dermatitis and nephropathy syndrome,” Vet.", "Rec.", "146:40-43 (2000); P. Spillane et al., “Porcine circovirus infection in the Republic of Ireland,” Vet.", "Rec.", "143:511-512 (1998); G. J. Wellenberg et al., “Isolation and characterization of porcine circovirus type 2 from pigs showing signs of post-weaning multisystemic wasting syndrome in the Netherlands,” Vet.", "Quart.", "22:167-72 (2000)) and some countries in Asia (C. Choi et al., “Porcine postweaning multisystemic wasting syndrome in Korean pig: detection of porcine circovirus 2 infection by immunohistochemistry and polymerase chain reaction,” J. Vet.", "Diagn.", "Invest.", "12:151-153 (2000); A. Onuki et al., “Detection of porcine circovirus from lesions of a pig with wasting disease in Japan,” J. Vet.", "Med.", "Sci.", "61:1119-1123 (1999)).", "PMWS potentially has a serious economic impact on the swine industry worldwide.", "The primary causative agent of PMWS is a pathogenic strain of PCV designated as porcine circovirus type 2 or PCV2 (G. M. Allan et al., “Novel porcine circoviruses from pigs with wasting disease syndromes,” Vet.", "Rec.", "142:467-468 (1998); G. M. Allan et al., “Isolation of porcine circovirus-like viruses from pigs with a wasting disease in the USA and Europe,” J. Vet.", "Diagn.", "Invest.", "10:3-10 (1998); G. M. Allan et al., “Isolation and characterisation of circoviruses from pigs with wasting syndromes in Spain, Denmark and Northern Ireland,” Vet.", "Microbiol.", "66:115-23 (1999); G. M. Allan and J.", "A. Ellis, 2000, supra; J. Ellis et al., 1998, supra; A. L. Hamel et al., 1998, supra; B. M. Meehan et al., 1998, supra; I. Morozov et al., 1998, supra).", "The complete genomic sequence of the PMWS-associated PCV2 and nonpathogenic PCV1 have been determined (R. Larochelle et al., “Genetic characterization and phylogenetic analysis of porcine circovirus type 2 (PCV2) strains from cases presenting various clinical conditions,” Virus Res.", "90:101-112 (2002); M. Fenaux et al., “Genetic characterization of type 2 porcine circovirus (PCV-2) from pigs with postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential PCR-restriction fragment length polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2,” J. Clin.", "Microbiol.", "38:2494-503 (2000); A. L. Hamel et al., 1998, supra; J. Mankertz et al., 1998, supra; B. M. Meehan et al., 1997, supra; B. M. Meehan et al., 1998, supra; I. Morozov et al., 1998, supra).", "PCV1 is ubiquitous in pigs but is not pathogenic to pigs.", "In contrast, the genetically related PCV2 is pathogenic and causes PMWS in pigs.", "Sequence analyses reveals that the PMWS-associated PCV2 typically shares only about 75% nucleotide sequence identity with the nonpathogenic PCV1.Some other strains may vary somewhat to about 74% to about 76% nucleotide sequence identity.", "Both PCV1 and PCV2 have a very similar genomic organization and are small, non-enveloped viruses with a single stranded circular DNA genome of about 1.76 kb.", "The PCV genome contains at least two functional open reading frames (ORFs): ORF1 (930 bp) encodes the Rep proteins involved in viral replication (A. K. Cheung, ‘Transcriptional analysis of porcine circovirus,” Virology 305: 168-180 (2003)) and ORF2 (699 bp) encodes the major immunogenic viral capsid protein (A. K. Cheung, 2003, supra; P. Nawagitgul et al., “Modified indirect porcine circovirus (PCV) type 2-based and recombinant capsid protein (ORF2)-based ELISA for the detection of antibodies to PCV,” Immunol.", "Clin.", "Diagn.", "Lab Immunol.", "9(1):33-40 (January 2002); P. Nawagitgul et al., “Open reading frame 2 of porcine circovirus type 2 encodes a major capsid protein,” J. Gen. Virol.", "81:2281-2287 (2000)).", "Initial attempts to reproduce clinical PMWS in conventional pigs by PCV2 inoculation were unsuccessful (M. Balasch et al., “Experimental inoculation of conventional pigs with tissue homogenates from pigs with post-weaning multisystemic wasting syndrome,” J. Comp.", "Pathol.", "121:139-148 (1999); M. Fenaux et al., “Cloned Genomic DNA of Type 2 Porcine Circovirus (PCV-2) Is Infectious When Injected Directly into the Liver and Lymph Nodes of SPF Pigs: Characterization of Clinical Disease, Virus Distribution, and Pathologic Lesions,” J. Virol.", "76:541-551 (2002)).", "Experimental reproduction of clinical PMWS in gnotobiotic pigs and conventional pigs with tissue homogenates from pigs with naturally occurring PMWS and with cell culture propagated PCV2 produced mixed results.", "Clinical PMWS was reproduced in gnotobiotic (SPF) pigs and colostrum-deprived and caesarian-derived pigs co-infected with PCV2 and porcine parvovirus (PPV) (G. M. Allan et al., “Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus,” J. Comp.", "Pathol.", "121:1-11 (1999); S. Krakowka et al., “Viral wasting syndrome of swine: experimental reproduction of postweaning multisystemic wasting syndrome in gnotobiotic swine by coinfection with porcine circovirus 2 and porcine parvovirus,” Vet.", "Pathol.", "37:254-263 (2000)), and in PCV2-inoculated gnotobiotic pigs when their immune system was activated by keyhole hemocyanin in incomplete Freund's adjuvant (S. Krakowka et al., “Activation of the immune system is the pivotal event in the production of wasting disease in pigs infected with porcine circovirus-2 (PCV-2),” Vet.", "Pathol.", "38:31-42 (2001)).", "Clinical PMWS was also reproduced in cesarean derived/colostrum deprived pigs (CD/CD) inoculated with PCV2 alone (P. A. Harms et al., “Experimental reproduction of severe disease in CD/CD pigs concurrently infected with type 2 porcine circovirus and porcine reproductive and respiratory syndrome virus,” Vet.", "Pathol.", "38:528-539 (2001)) and in conventional pigs co-infected with PCV2 and either porcine parvovirus (PPV) or porcine reproductive and respiratory syndrome virus (PRRSV) (A. Rivora et al., “Experimental inoculation of conventional pigs with porcine reproductive and respiratory syndrome virus and porcine circovirus 2,” J. Virol.", "76: 3232-3239 (2002)).", "In cases of the PRRSV/PCV2 co-infection, the PMWS characteristic pathological signs such as lymphoid depletion, granulomatous inflammation and necrotizing hepatitis are induced by PCV2 and not by PRRSV (P. A. Harms et al., 2001, supra).", "However, clinical PMWS was not reproduced in gnotobiotic pigs infected with PCV2 alone (G. M. Allan et al., “Experimental infection of colostrums deprived piglets with porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) potentiates PCV2 replication,” Arch.", "Virol.", "145:2421-2429 (2000); G. M. Allan et al., “A sequential study of experimental infection of pigs with porcine circovirus and porcine parvovirus: immunostaining of cryostat sections and virus isolation, J. Vet.", "Med.", "47:81-94 (2000); G. M. Allan et al., “Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus,” J. Comp.", "Pathol.", "121:1-11 (1999); M. Balasch et al., 1999, supra; J. Ellis et al., “Reproduction of lesions of postweaning multisystemic wasting syndrome in gnotobiotic piglets,” J. Vet.", "Diagn.", "Invest.", "11:3-14 (1999); S. Kennedy et al., “Reproduction of lesions of postweaning multisystemic wasting syndrome by infection of conventional pigs with porcine circovirus type 2 alone or in combination with porcine parvovirus” J. Comp.", "Pathol.", "122:9-24 (2000); S. Krakowka et al., 2001, supra; S. Krakowka et al., 2000, supra; R. M. Pogranichnyy et al., “Characterization of immune response of young pigs to porcine circovirus type 2 infection,” Viral.", "Immunol.", "13:143-153 (2000)).", "The virus inocula used in these studies were either homogenates of tissues from pigs with naturally occurring PMWS, or virus propagated in PK-15 cell cultures (G. M. Allan et al., “Experimental infection of colostrums deprived piglets with porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) potentiates PCV2 replication,” Arch.", "Virol.", "145:2421-2429 (2000); G. M. Allan et al., “A sequential study of experimental infection of pigs with porcine circovirus and porcine parvovirus: immunostaining of cryostat sections and virus isolation, J. Vet.", "Med.", "47:81-94 (2000); G. M. Allan et al., “Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus,” J. Comp.", "Pathol.", "121:1-11 (1999); M. Balasch et al., 1999, supra; J. Ellis et al., 1999, supra; S. Kennedy et al., 2000, supra; S. Krakowka et al., 2001, supra; S. Krakowka et al., 2000, supra; R. M. Pogranichnyy et al., 2000, supra).", "Since tissue homogenates may contain other common swine agents such as PPV and porcine reproductive and respiratory syndrome virus (PRRSV) (G. M. Allan et al., “Experimental infection of colostrums deprived piglets with porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) potentiates PCV2 replication,” Arch.", "Virol.", "145:2421-2429 (2000); G. M. Allan et al., “Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus,” J. Comp.", "Pathol.", "121:1-11 (1999); G. M. Allan and J.", "A. Ellis, 2000, supra; J.", "A. Ellis et al., “Coinfection by porcine circoviruses and porcine parvovirus in pigs with naturally acquired postweaning multisystemic wasting syndrome,” J. Vet.", "Diagn.", "Invest.", "12:21-27 (2000); C. Rosell et al., 2000, supra), and since the ATCC PK-15 cell line used for PCV2 propagation was persistently infected with PCV1 (G. C. Dulac and A. Afshar, 1989, supra), the clinical disease and pathological lesions reproduced in those studies may not be solely attributable to PCV2 infection (G. M. Allan et al., “Experimental infection of colostrums deprived piglets with porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) potentiates PCV2 replication,” Arch.", "Virol.", "145:2421-2429 (2000); G. M. Allan et al., “A sequential study of experimental infection of pigs with porcine circovirus and porcine parvovirus: immunostaining of cryostat sections and virus isolation, J. Vet.", "Med.", "47:81-94 (2000); G. M. Allan et al., “Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus,” J. Comp.", "Pathol.", "121:1-11 (1999); G. M. Allan and J.", "A. Ellis, 2000, supra; J.", "A. Ellis et al., 2000, supra).", "Clinical PMWS has also been reproduced in PCV2-inoculated CDCD pigs when vaccinated with Mycoplasma hyopneumoniae (G. M. Allan et al., “Immunostimulation, PCV-2 and PMWS,” Vet.", "Rec.", "147:171-172 (2000)).", "Two recent field studies by G. M. Allan et al., “Neonatal vaccination for Mycoplasma hyopneumoniae and postweaning multisystemic wasting syndrome: a field trial,” Pig J.", "48:34-41 (2001), and S. C. Kyriakis et al., “The effects of immuno-modulation on the clinical and pathological expression of postweaning multisystemic wasting syndrome,” J. Comp.", "Pathol.", "126:38-46 (2002), tested the effect of immuno-modulation by Mycoplasma hyopneumoniae vaccine on the development of PMWS in endemic herds, and showed a significant decrease in PMWS cases in unvaccinated groups compared to the vaccinated animals.", "However, another recent study using conventional SPF piglets under controlled laboratory conditions could not reproduce such an effect, suggesting that vaccinations with M. hyopneumoniae may potentially influence the development of clinical PMWS but it is clearly a secondary role to a PCV2 infection.", "Based on these and other studies, PCV2 is nevertheless considered to be the primary but not the exclusive causative agent of PMWS.", "The lack of an infectious virus stock of a biologically pure form of PCV2 has impeded the understanding of PCV2 pathogenesis and the etiological role of PCV2 in PMWS.", "Vaccinations against PPV and possibly PRRSV have not consistently been shown to prevent the onset of PMWS in PCV2 infected pigs.", "Consequently, finding a safe yet potent vaccine that specifically targets PMWS has been difficult.", "There is a definite art-recognized need in the veterinary field to produce an efficacious, safe vaccine against PCV2 infections and PMWS.", "U.S. Pat.", "No.", "6,287,856 (Poet et al.)", "and WO 99/45956 concern nucleic acids from psittacine beak and feather disease virus (BFDV), a circovirus that infects avian species, and from porcine circovirus (PCV).", "The patent proposes vaccine compositions comprising naked DNA or mRNA and discloses a nucleic acid vector for the transient expression of PCV in a eukaryotic cell comprising a cis-acting transcription or translation regulatory sequence derived from the human cytomegalovirus immediate or early gene enhancer or promoter functionally linked to a nucleic acid of the sequence.", "However, since the PCV DNA is derived solely from the PK-15 cell line, it is likely to comprise the nonpathogenic PCV1 discovered nearly 30 years ago by I. Tischer et al., 1974, supra, and, therefore, it is not likely to be effective in eliciting an immune reaction to PCV2 or infections caused by PCV2.Subunit vaccines of recombinant proteins made from vectors comprising open reading frames are also suggested in the patent but the open reading frames from PCV are not well characterized or distinguished from each other.", "Since the source of the PCV DNA is PK-15 cells, the proteins made from those vectors comprising the open reading frames of PCV1 would not possess reliable immunogenic properties, if any, against PCV2.U.S.", "Pat.", "No.", "6,217,883 (Allan et al.)", "and French Patent No.", "2,781,159B relate to the isolation of five PCV strains from pulmonary or ganglionic samples taken from pigs infected with PMWS in Canada, California and France (Brittany), and their use in combination with at least one porcine parvovirus antigen in immunogenic compositions.", "Proteins encoded by PCV2 open reading frames (ORF) consisting of ORF1 to ORF13 are broadly described in the patent but there is no exemplification of any specific protein exhibiting immunogenic properties.", "The patent further discloses vectors consisting of DNA plasmids, linear DNA molecules and recombinant viruses that contain and express in vivo a nucleic acid molecule encoding the PCV antigen.", "Several other references, for example, U.S. Pat.", "No.", "6,391,314 B1; U.S. Pat.", "No.", "6,368,601 B1; French Patent No.", "2,769,321; French Patent No.", "2,769,322; WO 01/96377 A2; WO 00/01409; WO 99/18214; WO 00/77216 A2; WO 01/16330 A2; WO 99/29871; etc., also describe the administration of PCV1 or PCV2 polypeptides or the nucleic acids encoding the polypeptides of various strains.", "However, the nonpathogenic PCV1 will not be useful against PCV2 infections and the pathogenic PCV2 strains described in the art, even if attenuated, are likely to be of limited value due to the usual tendency of a live virus to revert to its virulent state.", "Therefore, there is still a long-standing need in the art for a live, infectious, nonpathogenic antigen for the inoculation of pigs against serious infection or PMWS caused by PCV2 that is efficacious and remains safe in veterinary vaccines.", "These goals are met by the construction of the new live chimeric porcine circovirus described herein, which is based upon the genomic backbone of the nonpathogenic PCV1 isolated by I. Tischer et al.", "almost 30 years ago.", "The novel chimeric porcine circovirus of the present invention is able to satisfy that long-standing need by uniquely and advantageously retaining the nonpathogenic phenotype of PCV1 but eliciting specific immune response against pathogenic PCV2.PCV2 causes pathological lesions characteristic of PMWS in specific-pathogen-free (SPF) pigs whereas PCV1 does not (M. Fenaux et al., 2002, supra).", "Based on the current studies, it is also observed that cell culture-derived PCV1 replicates more efficiently in PK-15 cells than PCV2 (see also M. Fenaux et al., “Immunogenicity and pathogenicity of the chimeric infectious DNA clones between pathogenic type 2 porcine circovirus (PCV2) and non-pathogenic PCV1 in weaning pigs,” J. Virol.", "77:11232-11243 (2003)).", "However, the genetic determinants for PCV2 pathogenicity in pigs and for the enhanced growth ability of PCV1 in PK-15 cells are not known.", "Thus, another set of objectives of the present invention is to identify and characterize the genetic determinants for PCV2 pathogenicity in vivo and for replication in vitro.", "BRIEF SUMMARY OF THE INVENTION The present invention concerns infectious chimeric DNA clones of porcine circovirus (PCV) and live chimeric viruses derived from the DNA clones that are useful as vaccines.", "The new live chimeric, genetically avirulent viruses are made from the nonpathogenic PCV1 genomic structure in which an immunogenic gene of a pathogenic PCV2 strain replaces a gene of the PCV1, typically in the same corresponding position.", "The invention encompasses the biologically functional plasmids, viral vectors and the like that contain the new recombinant nucleic acid molecules described herein, suitable host cells transfected by the vectors comprising the DNA and the immunogenic polypeptide expression products.", "Included within the scope of the present invention is a novel method of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2 comprising administering to a pig in need of such protection an immunologically effective amount of a vaccine comprising, for example, the cloned chimeric DNA in a plasmid, a chimeric virus derived from the chimeric DNA clone, the polypeptide products expressed from the DNA described herein, etc.", "A further embodiment of the invention is drawn to novel mutants of the PCV2 immunogenic capsid gene and protein, and the introduction of the mutations in the chimeric clones to facilitate cell culture growth and ensure vaccine safety.", "The invention also provides new infectious PCV2 molecular DNA and reciprocal chimeric DNA clones of PCV that find use as experimental models in obtaining or characterizing the novel avirulent viral vaccines.", "BRIEF DESCRIPTION OF THE DRAWINGS The background of the invention and its departure from the art will be further described hereinbelow with reference to the accompanying drawings, wherein: FIG.", "1 represents the construction of an infectious PCV2 molecular DNA clone.", "The relative positions of the primer pair used to amplify the complete PCV2 genome are indicated by the arrows (reverse primer PCVSAC2, forward primer PCVSAC2).", "The PCV2 genomic DNA amplified by PCR is digested with SacII restriction enzyme, and purified.", "The purified and SacII-digested genomic DNA is ligated to form concatemers.", "Ligated concatemers are separated by gel electrophoresis, the tandem genome dimer of PCV2 is purified and cloned into pSK vector that is pre-digested with SacII enzyme to produce a molecular PCV2 DNA clone.", "FIGS.", "2A and 2B illustrate that the cloned PCV2 plasmid DNA is infectious when transfected in vitro in PK-15 cells.", "FIG.", "2A shows the detection of PCV2 antigen by immunofluorescence assay (IFA) in PK-15 cells transfected with the cloned PCV2 plasmid DNA.", "Intense immunolabeling of PCV2 antigen is visualized in the nucleus, and to a lesser degree, cytoplasm of the transfected cells.", "FIG.", "2B shows mock-transfected PK-15 cells.", "FIG.", "3A shows the lungs from a pig inoculated by intralymphoid route with PCV2 DNA at 21 DPI.", "The lungs are rubbery, failed to collapse, and are mottled tan-red.", "Tracheobronchial lymph nodes are markedly enlarged and tan (arrows).", "FIG.", "3B represents a microscopic section of a normal lung from a control pig (25X).", "FIG.", "3C represents a microscopic section of the lung from the pig in FIG.", "3A.", "Note the peribronchiolar lymphohistiocytic inflammation and mild necrotizing bronchiolitis (25X).", "FIG.", "3D illustrates the immunohistochemical staining of the lung in FIG.", "3A.", "Note the PCV2 antigen in macrophages (arrows) and fibroblast-like cells (arrow heads) around airways (64X).", "FIG.", "4A shows a normal lymph node from a control pig.", "Note the well-defined lymphoid follicles (arrows) (25X).", "FIG.", "4B represents a microscopic section of the tracheobronchial lymph node from the pig in FIG.", "3A inoculated 21 days previously by intralymphoid route with cloned PCV2 genomic DNA.", "Lymphoid follicles are poorly defined, there is mild-to-moderate lymphoid depletion, and mild multifocal granulomatous inflammation (25X).", "FIG.", "4C represents a microscopic section of the lymph node in FIG.", "4B in a larger magnification focusing on one follicle.", "Note the poorly defined follicle with macrophages and giant cells (arrow) replacing follicular lymphocytes (64X).", "FIG.", "4D illustrates the immunohistochemical detection of PCV2 antigen in the same lymph node as FIG.", "4B in macrophages (arrows) and giant cells (small arrowheads), and dendritic-like cells (large arrowheads) in the follicles (64X).", "FIG.", "5 illustrates the construction of a chimeric PCV1-2 (PCV1/PCV2) DNA clone with the nonpathogenic PCV1 genome carrying the immunogenic ORF2 capsid gene of the pathogenic PCV2.The dimmerized DNA clone is used for in vitro transfection of PK-15 cells to produce live chimeric virus expressing ORF2 protein of PCV2, and in vivo animal experiments to confirm activity.", "FIG.", "6 represents the construction and organization of the infectious PCV1, PCV2, chimeric PCV1-2 and reciprocal chimeric PCV2-1 molecular DNA clones.", "The PCV2 DNA clone is constructed by ligating two full-length linear PCV2 genomes in tandem into the Bluescript SK vector (pSK) by the general methods described previously (M. Fenaux et al., 2002, supra).", "PCV1 DNA clone is constructed by ligating two full-length linear PCV1 genomes in tandem into pSK vector.", "Chimeric PCV1-2 DNA clone is constructed by replacing the ORF2 capsid gene of PCV1 with that of the PCV2 in the nonpathogenic PCV1 genomic backbone in pSK vector.", "Reciprocal chimeric PCV2-1 DNA clone is constructed by replacing the ORF2 capsid gene of the pathogenic PCV2 with that of the nonpathogenic PCV1 in the pathogenic PCV2 genomic backbone in pSK vector.", "Both chimeric clones are dimmers in pSK vector.", "The arrows represent the relative locations of the PCR primers for the detection of PCV1, PCV2, PCV1-2 and PCV2-1 viremia in inoculated animals.", "FIGS.", "7A-7J demonstrate that the PCV1, PCV2, chimeric PCV1-2 and reciprocal chimeric PCV2-1 DNA clones are infectious and express respective viral antigens when transfected in vitro in PK-15 cells.", "The left panel (7A, 7C, 7E, 7G and 7I) is stained with monoclonal antibody against the PCV1 ORF2.The right panel (7B, 7D, 7F, 7H and 7J) is stained with antibody against PCV2.Panels 7A and 7B are mock transfected PK-15 cells.", "Panels 7C and 7D are PK-15 cells transfected with the PCV1 DNA clone.", "Panels 7E and 7F are PK-15 cells transfected with the PCV2 DNA clone.", "Panels 7G and 7H are PK-15 cells transfected with the chimeric PCV1-2 DNA clone.", "Panels 7I and 7J are PK-15 cells transfected with the reciprocal chimeric PCV2-1 DNA clone.", "FIG.", "8 represents the full-length DNA sequence of the cloned PCV2 molecular DNA (which corresponds to SEQ ID NO:1).", "FIG.", "9 represents the full-length DNA sequence of the cloned chimeric PCV1-2 DNA (which corresponds to SEQ ID NO:2).", "FIG.", "10 represents the 702 bp (699 bp sequence plus the 3 nucleotide stop codon) DNA sequence of the immunogenic ORF2 capsid gene of the cloned chimeric PCV1-2 DNA (which corresponds to SEQ ID NO:3).", "FIG.", "11 represents the putative amino acid translation of the immunogenic ORF2 capsid gene of the chimeric PCV1-2 DNA (which corresponds to SEQ ID NO:4).", "FIG.", "12 shows one-step growth curves of PCV1, PCV2 VP1 and PCV2 VP120.Duplicate synchronized PK-15 cell cultures are each infected with PCV1, PCV2 VP1 or PCV2 VP120, all at an M.O.I.", "of 0.1.All three viruses have a titer of about 101.5 TCID50/ml at 12 hours postinoculation.", "PCV1 and PCV2 VP120 replicate more efficiently in vitro than PCV2 VP1 does (p=0.0053).", "FIG.", "13 is a schematic diagram of amino acid mutations in the capsid protein during serial passages of PCV2 in PK-15 cells.", "Serial passage numbers are indicated as VP1, VP30, VP60, VP90 and VP120.Known field isolates of PCV2 and PCV1 from different geographic origins are also compared for these two mutations.", "FIG.", "14 shows the quantitative real-time PCR results of PCV2 VP1 and PCV2 VP120 viral genomic copy loads in 1 ml of serum sample collected at −1, 7, 14, 21, 28, 35 and 42 days post inoculation (DPI) from Groups 1, 2 and 3 pigs.", "Group 2 pigs inoculated with PCV2 VP120 that are positive for PCV2 DNA are indicated with a σ.", "The numbers (10, 9, 8, 6, 5, 5) inside the symbol Δ on the X-axis indicate the number of pigs in Group 2 that are negative for PCV2 viremia on the respective DPI.", "Group 3 pigs inoculated with PCV2 VP1 that are positive for PCV2 DNA are indicated with symbol O.", "The numbers (3, 2, 2, 2, 2, 4) inside the symbol O on the X-axis indicate the number of pigs in Group 3 that are negative for PCV2 viremia on the respective DPI.", "The PCV2 genomic copy loads are represented as a log of copy numbers per 1 ml of serum (Y-axis).", "DETAILED DESCRIPTION OF THE INVENTION In accordance with the present invention, there are provided infectious molecular and chimeric nucleic acid molecules of porcine circovirus (PCV), live chimeric viruses produced from the chimeric nucleic acid molecule and veterinary vaccines to protect pigs from viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2.The invention further provides immunogenic polypeptide expression products that may be used as vaccines.", "Also described are two novel nucleotide mutations of the PCV2 immunogenic capsid gene resulting in two novel amino acid mutations of the PCV2 immunogenic capsid protein that are shown to be responsible for increased growth rate in vitro and attenuation of virulence in vivo, and therefore find beneficial use in the chimeric nucleic acid molecule of this invention.", "The new avirulent, infectious chimeric DNA molecule of PCV (PCV1-2) comprises a nucleic acid molecule encoding an infectious, nonpathogenic PCV1 that contains an immunogenic open reading frame (ORF) gene of a pathogenic PCV2 in place of an ORF gene in the PCV1 genome.", "The infectious chimeric PCV1-2 DNA clone preferably contains the immunogenic capsid gene (ORF2) of the PCV2 DNA cloned in the genomic backbone of the infectious, nonpathogenic PCV1 DNA clone.", "Generally, the capsid gene of the PCV2 DNA replaces the ORF2 gene of the PCV1 DNA in the nonpathogenic PCV1 genomic structure but it is contemplated that a variety of positional permutations may be constructed through genetic engineering to obtain other avirulent or attenuated chimeric DNA clones.", "The reciprocal chimeric infectious PCV2-1 DNA clone between PCV1 and PCV2 is disclosed as a control to analyze the chimeric PCV1-2 clone of the invention and is constructed by replacing the capsid gene of PCV2 with that of PCV1 in the backbone of the pathogenic PCV2 infectious DNA clone.", "In addition to being an experimental model, the reciprocal chimeric PCV2-1 DNA clone may find use in making specially tailored vaccines.", "The cloned genomic DNA of PCV2 described herein is shown to be in vitro and in vivo infectious when transfected into PK-15 cells and given to pigs.", "The infectious PCV2 DNA clone produces pathological lesions characteristic of PMWS in pigs allowing for an improved characterization of clinical disease and understanding of virus distribution in the tissue cells.", "This new, readily reproducible pathogenic agent lends itself to the development of a suitable vaccination program to prevent PMWS in pigs.", "The novel chimeric PCV1-2 DNA clone is also infectious by both in vitro transfection of PK-15 cells and in vivo administration to pigs.", "In transfected PK-15 cells, the chimeric PCV1-2 DNA clone expresses the PCV2 capsid antigen (the immunogenic capsid protein of PCV2) whereas the reciprocal chimeric PCV2-1 DNA clone expresses the PCV1 capsid antigen, which is demonstrated by immunofluorescence assay (IFA) using antibodies specific to PCV1 or PCV2 capsid antigen.", "Seroconversion to PCV2-specific antibody is detected in pigs inoculated with the infectious PCV2 clone as well as the chimeric PCV1-2 clone.", "Detecting the seroconversion to PCV2-specific antibody establishes that the chimeric PCV1-2 DNA clone induces the PCV2-specific antibody in infected pigs and, consequently, acts to protect inoculated pigs from infection with PCV2.The below examples describe the evaluation of the immunogenicity and pathogenicity of the chimeric DNA clones in inoculated pigs in more detail.", "Basically, seroconversions to antibodies against PCV2 ORF2 antigen are detected in pigs inoculated with the PCV2 DNA clone (Group 3) and the chimeric PCV1-2 DNA clone (Group 4).", "All of the pigs inoculated with the PCV1 clone and the reciprocal chimeric PCV2-1 DNA clone (Groups 2 and 5, respectively) seroconvert to the PCV1 antibody.", "The viruses recovered from selected pigs in each group are partially sequenced and confirmed to be the authentic respective infectious DNA clones used in the inoculation.", "Gross and microscopic lesions in various tissues of animals inoculated with the PCV2 DNA clone are significantly more severe than those found in pigs inoculated with PCV1, chimeric PCV1-2 and reciprocal chimeric PCV2-1 DNA clones.", "Surprisingly and advantageously, the chimeric PCV1-2 infectious DNA clone having the immunogenic capsid gene (ORF2) of the pathogenic PCV2 cloned into the nonpathogenic PCV1 genomic backbone induces a specific antibody response to the pathogenic PCV2 capsid antigen while it uniquely retains the nonpathogenic nature of PCV1 in pigs.", "Animals inoculated with the chimeric PCV1-2 infectious DNA clone develop a mild infection resembling that of PCV1 inoculated animals while seroconverting to the antibody against the ORF2 capsid protein of the pathogenic PCV2.The average length of viremia observed in PCV1 and chimeric PCV1-2 inoculated animals is shorter, 0.625 weeks and 1 week respectively, than that in pathogenic PCV2 inoculated animals which is about 2.12 weeks.", "The lack of detectable chimeric PCV1-2 viremia in some inoculated animals does not affect seroconversion to antibody against PCV2 ORF2 capsid protein in the PCV1-2 inoculated pigs (Group 4).", "The results indicate that, even though the chimeric PCV1-2 viremia is short or undetectable in some inoculated animals, the chimeric PCV1-2 virus is able to induce antibody response against PCV2 ORF2 capsid protein.", "The special ability of the chimeric PCV1-2 infectious DNA clone to induce the immune response specific to the pathogenic PCV2 immunogenic ORF2 capsid protein yet remain nonpathogenic to pigs makes the chimeric PCV1-2 clone particularly useful as a genetically engineered live-attenuated vaccine and other types of vaccines.", "The novel, purified and isolated nucleic acid molecules of this invention comprise the full-length DNA sequence of the cloned chimeric PCV1-2 DNA set forth in SEQ ID NO:2, shown in FIG.", "9 and deposited in the American Type Culture Collection under Patent Deposit Designation PTA-3912; its complementary strand (i.e., reverse and opposite base pairs) or the nucleotide sequences having at least 95% homology to the chimeric nucleotide sequence (i.e., a significant active portion of the whole gene).", "Conventional methods that are well known in the art can be used to make the complementary strands or the nucleotide sequences possessing high homology, for instance, by the art-recognized standard or high stringency hybridization techniques.", "The purified and isolated nucleic acid molecule comprising the DNA sequence of the immunogenic capsid gene of the cloned chimeric PCV1-2 DNA is also set forth in SEQ ID NO:3 and FIG.", "10.Suitable cells containing the chimeric nucleic acid molecule uniquely produce live, infectious chimeric porcine circoviruses.", "The live, infectious chimeric virus is derived from the chimeric DNA clone by transfecting PK-15 cells via in vitro and in vivo transfections as illustrated herein.", "A preferred example of the cloned chimeric PCV1-2 DNA is the nucleotide sequence set forth in SEQ ID NO:2 and FIG.", "9.The invention further envisions that the chimeric virus is derived from the complementary strand or the nucleotide sequences having a high homology, at least 95% homology, to the chimeric nucleotide sequence.", "Also included within the scope of the present invention are biologically functional plasmids, viral vectors and the like that contain the new recombinant nucleic acid molecules described herein, suitable host cells transfected by the vectors comprising the chimeric and molecular DNA clones and the immunogenic polypeptide expression products.", "A particularly preferred immunogenic protein has the amino acid sequence set forth in SEQ ID NO:4 and FIG.", "11.The biologically active variants thereof are further encompassed by the invention.", "One of ordinary skill in the art would know how to modify, substitute, delete, etc., amino acid(s) from the polypeptide sequence and produce biologically active variants that retain the same, or substantially the same, activity as the parent sequence without undue effort.", "To produce the immunogenic polypeptide products of this invention, the process may include the following steps: growing, under suitable nutrient conditions, prokaryotic or eukaryotic host cells transfected with the new recombinant nucleic acid molecules described herein in a manner allowing expression of said polypeptide products, and isolating the desired polypeptide products of the expression of said nucleic acid molecules by standard methods known in the art.", "It is contemplated that the immunogenic proteins may be prepared by other techniques such as, for example, biochemical synthesis and the like.", "Another embodiment of the present invention relates to novel mutations of the nucleotide and amino acid sequences of the PCV2 immunogenic capsid gene and protein.", "PCV2 is the primary causative agent of postweaning multisystemic wasting syndrome (PMWS), whereas the PK-15 cell culture-derived porcine circovirus type 1 (PCV1) is nonpathogenic to pigs.", "The molecular mechanisms of PCV2 replication and pathogenesis have been poorly understood.", "As fully described herein, the important identification and isolation of two amino acid mutations within the PCV2 capsid protein that are vital for PCV2 pathogenicity in vivo and improved growth ability in PK-15 cells provides a viable mechanism by which the chimeric PCV1-2 vaccine of the present invention can grow better in cell cultures or be made safer in vaccinations.", "To identify genetic determinants for virulence and replication, a pathogenic PCV2 isolate is serially passaged for 120 times in PK-15 cells, and the viruses that are harvested from passages 1 (VP1) and 120 (VP120) are biologically, genetically and experimentally characterized.", "A one-step growth curve is used to compare the growth characteristics of PCV1, PCV2 VP1, and PCV2 VP120.The results show that the PCV2 VP120 virus replicates to a similar titer as PCV1 but more efficiently than PCV2 VP1 in PK-15 cells with at least 1 log difference.", "The complete genomic sequences of viruses at passages 0, 30, 60, 90, and 120 are determined.", "Two novel amino acid mutations are identified in the capsid gene after 120 passages, and it is shown that these two mutations are responsible for the increased growth rate in vitro and the attenuation of virulence in vivo.", "There are only two nucleotide differences as well, cytosine to guanine (C to G) and adenine to cytosine (A to C), both of which are non-silent mutations that result in the two amino acid changes.", "The first mutation occurs at passage 30, in which a proline at position 110 of the capsid protein is substituted for an alanine (P110A), and this mutation remains in the subsequent passages.", "In position 328 of the nucleotide sequence, cytosine changes to guanine (C to G) leading to this amino acid change of P110A.", "The second mutation, a substitution of an arginine for a serine at position 191 of the capsid protein (R191S), appears at passage 120 but not in earlier passages.", "In nucleotide position 573, adenine changes to cytosine (A to C) leading to this second amino acid change of R191S.", "To characterize the pathogenicity of the VP120 virus, 31 specific-pathogen-free (SPF) pigs are randomly divided into three groups.", "Ten pigs in Group 1 receive phosphate buffered saline as negative controls.", "Eleven Group 2 pigs are inoculated intramuscularly and intranasally with 104.9TCID50 of PCV2 VP120.Ten pigs in Group 3 are inoculated with 104.9TCID50 of PCV2 VP1.PCV2 viremia is detected in 9/10 pigs in the PCV2 VP1 group, but only in 4/11 pigs in PCV120 group.", "The viremia in VP1 group (mean 3 weeks) lasts longer than that of VP120 group (mean 1.6 weeks).", "In addition, the PCV2 genomic copy loads in serum, as determined by quantitative real-time PCR, in the PCV2 VP1 group are higher than those in PCV2 VP120 group (p<0.0001).", "Gross and histopathologic lesions found in pigs inoculated with PCV2 VP1 are more severe than those inoculated with PCV2 VP120 at both 21 and 42 DPI necropsies (p=0.0032 and p=0.0274, respectively).", "Taken together, the results demonstrate that the P110A and R191S mutations in the capsid of PCV2 enhance the growth ability of PCV2 in vitro and attenuate the virus in vivo.", "As a result of the P110A and R191S mutations in the capsid protein, PCV2 VP120 replicates more efficiently (p=0.0053) in PK-15 cells with at least 1 log difference in infectious titer compared to the passage 1 virus.", "PCV2 VP120 replicates to a similar level with the PK-15 cell culture-adapted PCV1, and thus these two mutations either alone or collectively are responsible for the enhanced growth of PCV2 VP120 in vitro.", "Allan et al.", "(G. M. Allan et al., 1994, supra) attempted to infect human Vero cells with PCV1.Intranuclear immune staining, characteristic of PCV1 replication, was not detected until the 6th cell culture passage in Vero cells.", "By passage 15, PCV1 replicated in Vero cells similarly to PK-15 cells.", "However, it has not been previously reported in the literature that 120 passages of the PCV2 in the PK-15 cell line will result in significantly improved replication efficiency to mimic the PK-15 cell culture-adapted PCV1.Surprisingly, when SPF piglets are inoculated with the PCV2 VP120, fewer pigs develop viremia with shorter duration and lower PCV2 genomic copy loads compared to PCV2 VP1 inoculated pigs.", "It is shown that the nonpathogenic PK-15 cell-adapted PCV1 has a short average viremia length of 0.625 weeks in infected pigs.", "Analyses of the gross, microscopic and IHC mean scores reveal that the PCV2 VP120 virus inoculated pigs have milder pathological lesions and clinical signs than the PCV2 VP1 virus inoculated pigs.", "Taken together, the results from this invention show that PCV2 VP 120 has advantageously been adapted to grow better in PK-15 cells and is attenuated in pathogenicity in vivo.", "After 120 passages in PK-15 cells, only two amino acid mutations are detected in the entire PCV2 genome, suggesting that the PCV2 genome is relatively stable.", "This may explain why the sequences of all known PCV2 field isolates identified to date are very conserved (M. Fenaux et al., 2002, supra; R. Larochelle et al., 2002, supra).", "The P110A mutation surprisingly occurs early (passage 30) during the serial passage, and involves two hydrophobic amino acids, proline and alanine.", "The change from proline to alanine may alter the tertiary structure of the capsid protein as proline is often involved in the bending regions of protein structures.", "This P110A mutation is then retained in the subsequent higher passages including passage 120.The uniqueness of the retained P110A mutation through passage 120 compared to the sequences of known PCV1 and PCV2 field isolates strongly correlates the mutation with a biological role.", "The R191S mutation occurs very late during the serial passage (between passages 90 and 120), and is also unique to the VP120 as the known PCV2 and PCV1 isolates do not have a serine residue at this position.", "Only glycine, alanine and threonine substitutions at this position have been previously identified in field isolates of PCV1 and PCV2.Amino acid substitutions induced by cell culture passage or chemical mutagenesis techniques have been routinely used for the attenuation of many viruses, and have led to the productions of many vaccines (G. F. Brooks et al., “Pathogenesis & control of viral diseases,” In: Jawetz, Melnick, & Adelberg's Medical Microbiology, 21st Ed.", "(Publishers Appleton & Lange) 30: 363-365 (1998)).", "A single amino acid substitution can lead to the attenuation of a virus.", "For example, it has been previously reported that substitution of a proline for a leucine at residue 101 of the nonstructural 4B protein of the mosquito-borne Dengue 4 (DEN4) virus resulted in decreased viral replication in mosquito but a proportionally increased replication in human Vero cells (K. A. Hanley et al., “A trade-off in replication in mosquito versus mammalian systems conferred by a point mutation in the NS4B protein of dengue virus type 4,” Virology.", "312:222-232 (2003)).", "Hence, the balancing control of efficient replication of DEN4 virus in either mosquito or human Vero cells was maintained by a single amino acid change.", "In the Circoviridae family, a single amino acid mutation in the VP1 capsid protein of CAV was found to be responsible for the pathogenicity of the virus in chickens (S. Yamaguchi et al., “Identification of a genetic determinant of pathogenicity in chicken anaemia virus,” J. Gen. Virol.", "82: 1233-1238 (2001)).", "Taken together, the results from the present invention strongly correlate the mutation to biological activity and demonstrate that P110A, R191S or collectively, is responsible for the attenuation of PCV2 VP120 in pigs or for the improved growth ability of PCV2 in PK-15 cells.", "Since the results from this invention demonstrate that the P110A and R191S mutations in the capsid of PCV2 enhance the growth ability of PCV2 in vitro and attenuate the virus in vivo, the P110A and R191S mutations (both singly and collectively) may be advantageously introduced into the capsid gene of the chimeric PCV1-2 vaccine to make the chimera PCV1-2 vaccine of the invention grow better in cell cultures or make it safer in pigs.", "This is accomplished by inserting the mutated immunogenic capsid gene containing the novel P110A and R191S mutations in the chimeric clones in lieu of using the ORF2 of the pathogenic PCV2.The mutations are introduced into the capsid gene of the PCV1-2 vaccine using art-recognized techniques such as those found in the instruction manual for the QuikChange® Multi Site-Directed Mutagenesis Kit commercially available from Stratagene Inc., La Jolla, Calif. Alternatively, the mutated PCV2 ORF2 for use in the chimeric virus may be made by well-known biochemical synthesis processes to substitute one or both of the proline and arginine with the alanine and serine amino acids at positions 110 and 191, respectively, of the immunogenic capsid protein.", "The final mutant clones may be readily sequenced to ensure that the intended P110A, R191S or both mutations are properly introduced and there is no other unwanted mutation.", "The PCV1-2 vaccine containing the mutation may be further tested in cell culture by routine procedures to select the combination that facilitates cell culture growth or ensures improved safety measures when vaccinating pigs due to the further attenuation of PCV2 virulent properties, if any persist.", "While the benefit of the PCV1-2 chimera lies in its natural avirulent trait, the alternative use of the mutated PCV2 ORF2 to make the PCV1-2 chimera provides another embodiment of the present invention that is available if further safening of the natural live chimera vaccine becomes warranted.", "Vaccines of the chimeric viral and molecular DNA clones, and methods of using them, are also included within the scope of the present invention.", "Inoculated pigs are protected from serious viral infection and PMWS caused by PCV2.The novel method protects pigs in need of protection against viral infection or PMWS by administering to the pig an immunologically effective amount of a vaccine according to the invention, such as, for example, a vaccine comprising an immunogenic amount of the chimeric PCV1-2 DNA, the cloned chimeric virus, a plasmid or viral vector containing the chimeric DNA of PCV1-2, the polypeptide expression products, the recombinant PCV2 DNA, etc.", "Other antigens such as PRRSV, PPV, other infectious swine agents and immune stimulants may be given concurrently to the pig to provide a broad spectrum of protection against viral infections.", "The vaccines comprise, for example, the infectious chimeric PCV1-2 DNA, the cloned PCV chimeric DNA genome in suitable plasmids or vectors such as, for example, the pSK vector, an avirulent, live chimeric virus, an inactivated chimeric virus, etc.", "in combination with a nontoxic, physiologically acceptable carrier and, optionally, one or more adjuvants.", "The vaccine may also comprise the infectious PCV2 molecular DNA clone described herein.", "The infectious chimeric PCV1-2 DNA, the plasmid DNA containing the infectious chimeric viral genome and the live chimeric virus are preferred with the live chimeric virus being most preferred.", "The avirulent, live viral vaccine of the present invention provides an advantage over traditional viral vaccines that use either attenuated, live viruses which run the risk of reverting back to the virulent state or killed cell culture propagated whole virus which may not induce sufficient antibody immune response for protection against the viral disease.", "The adjuvant, which may be administered in conjunction with the vaccine of the present invention, is a substance that increases the immunological response of the pig to the vaccine.", "The adjuvant may be administered at the same time and at the same site as the vaccine, or at a different time, for example, as a booster.", "Adjuvants also may advantageously be administered to the pig in a manner or at a site different from the manner or site in which the vaccine is administered.", "Suitable adjuvants include, but are not limited to, aluminum hydroxide (alum), immunostimulating complexes (ISCOMS), non-ionic block polymers or copolymers, cytokines (like IL-1, IL-2, IL-7, IFN-α, IFN-β, IFN-γ, etc.", "), saponins, monophosphoryl lipid A (MLA), muramyl dipeptides (MDP) and the like.", "Other suitable adjuvants include, for example, aluminum potassium sulfate, heat-labile or heat-stable enterotoxin isolated from Escherichia coli, cholera toxin or the B subunit thereof, diphtheria toxin, tetanus toxin, pertussis toxin, Freund's incomplete or complete adjuvant, etc.", "Toxin-based adjuvants, such as diphtheria toxin, tetanus toxin and pertussis toxin may be inactivated prior to use, for example, by treatment with formaldehyde.", "The vaccines may further contain additional antigens to promote the immunological activity of the infectious chimeric PCV DNA clones such as, for example, porcine reproductive and respiratory syndrome virus (PRRSV), porcine parvovirus (PPV), other infectious swine agents and immune stimulants.", "The new vaccines of this invention are not restricted to any particular type or method of preparation.", "The cloned viral vaccines include, but are not limited to, infectious DNA vaccines (i.e., using plasmids, vectors or other conventional carriers to directly inject DNA into pigs), live vaccines, modified live vaccines, inactivated vaccines, subunit vaccines, attenuated vaccines, genetically engineered vaccines, etc.", "These vaccines are prepared by standard methods known in the art.", "The live viral vaccine is generally the most desirable vaccine in that all possible immune responses are activated in the recipient of the vaccine, including systemic, local, humoral and cell-mediated immune responses.", "A killed vaccine, on the other hand, can only induce humoral immune response.", "Albeit the most desirable, however, live viral vaccines have several disadvantages, such as the potential risk of contamination with live adventitious viral agents or the risk that the virus may revert to virulence in the field.", "Remarkably, the unique PCV1-2 chimeric DNA of the present invention overcomes those disadvantages.", "Using only the immunogenic genes of the pathogenic PCV2, the chimeric DNA constructs a live, replicating chimeric virus that is nonpathogenic yet elicits the complete, beneficial immune responses of live viral vaccines against the pathogenic PCV2 virus.", "The live virus vaccine based on the chimeric virus will have little chance, if any, for reversion to a pathogenic phenotype.", "Thus, the new chimeric virus based on the structure of the nonpathogenic PCV1 has a huge advantage over any recombinant PCV2 DNA virus, any live, attenuated PCV2 vaccine or any other type of vaccine predicated solely on PCV2 for immunity against the PCV2 infections.", "Although the live viral vaccine is most preferred, other types of vaccines may be used to inoculate pigs with the new chimeric virus and other antigens described herein.", "To prepare inactivated virus vaccines, for instance, the virus propagation from the infectious DNA clone is done by methods known in the art or described herein.", "Serial virus inactivation is then optimized by protocols generally known to those of ordinary skill in the art.", "Inactivated virus vaccines may be prepared by treating the chimeric virus derived from the cloned PCV DNA with inactivating agents such as formalin or hydrophobic solvents, acids, etc., by irradiation with ultraviolet light or X-rays, by heating, etc.", "Inactivation is conducted in a manner understood in the art.", "For example, in chemical inactivation, a suitable virus sample or serum sample containing the virus is treated for a sufficient length of time with a sufficient amount or concentration of inactivating agent at a sufficiently high (or low, depending on the inactivating agent) temperature or pH to inactivate the virus.", "Inactivation by heating is conducted at a temperature and for a length of time sufficient to inactivate the virus.", "Inactivation by irradiation is conducted using a wavelength of light or other energy source for a length of time sufficient to inactivate the virus.", "The virus is considered inactivated if it is unable to infect a cell susceptible to infection.", "The preparation of subunit vaccines typically differs from the preparation of a modified live vaccine or an inactivated vaccine.", "Prior to preparation of a subunit vaccine, the protective or antigenic components of the vaccine must be identified.", "Such protective or antigenic components include certain amino acid segments or fragments of the viral capsid proteins which raise a particularly strong protective or immunological response in pigs; single or multiple viral capsid proteins themselves, oligomers thereof, and higher-order associations of the viral capsid proteins which form virus substructures or identifiable parts or units of such substructures; oligoglycosides, glycolipids or glycoproteins present on or near the surface of the virus or in viral substructures such as the lipoproteins or lipid groups associated with the virus, etc.", "Preferably, a capsid protein, such as the protein encoded by the ORF2 gene, is employed as the antigenic component of the subunit vaccine.", "Other proteins encoded by the infectious DNA clone may also be used.", "These immunogenic components are readily identified by methods known in the art.", "Once identified, the protective or antigenic portions of the virus (i.e., the “subunit”) are subsequently purified and/or cloned by procedures known in the art.", "The subunit vaccine provides an advantage over other vaccines based on the live virus since the subunit, such as highly purified subunits of the virus, is less toxic than the whole virus.", "If the subunit vaccine is produced through recombinant genetic techniques, expression of the cloned subunit such as the ORF2 (capsid) gene, for example, may be optimized by methods known to those in the art (see, for example, Maniatis et al., “Molecular Cloning: A Laboratory Manual,” Cold Spring Harbor Laboratory, Cold Spring Harbor, M A., 1989).", "If the subunit being employed represents an intact structural feature of the virus, such as an entire capsid protein, the procedure for its isolation from the virus must then be optimized.", "In either case, after optimization of the inactivation protocol, the subunit purification protocol may be optimized prior to manufacture.", "To prepare attenuated vaccines from pathogenic clones, the tissue culture adapted, live, pathogenic PCV2 is first attenuated (rendered nonpathogenic or harmless) by methods known in the art, typically made by serial passage through cell cultures.", "Attenuation of pathogenic clones may also be made by gene deletions or viral-producing gene mutations.", "Then, the attenuated PCV2 viruses may be used to construct additional chimeric PCV1-2 viruses that retain the nonpathogenic phenotype of PCV1 but can vary in the strength of the immunogenicity traits selected from the PCV2 genome through recombinant technology.", "Desirably, the attenuation of the PCV2 is accomplished by obtaining the P110A, R191S or both mutations in the ORF2 and using the mutant PCV2 to construct the chimeric PCV1-2 viruses as described herein.", "The most preferred vaccine employs the live chimeric virus DNA clone, in particular, the clone containing the immunogenic genes of PCV2 cloned in the backbone of the nonpathogenic PCV1.Advantageously, the live chimeric virus, which is naturally avirulent when constructed through genetic engineering, does not require time-consuming attenuation procedures.", "The virus uniquely serves as a live but nonpathogenic replicating virus that produces immunogenic proteins against PCV2 during virus replication, which can then elicit a full range of immune responses against the pathogenic PCV2.As a further benefit, the preferred live chimeric virus of the present invention provides a genetically stable vaccine that is easier to make, store and deliver than other types of attenuated vaccines.", "Avirulent or attenuated vaccines based upon chimeric viruses are generally considered as safe as, if not safer than, the traditionally modified live vaccines (J. Arroyo et al., “Molecular basis for attenuation of neurovirulence of a yellow fever Virus/Japanese encephalitis virus chimera vaccine (ChimeriVax-JE),” J. Virol.", "75(2):934-942 (2001); F. Guirakhoo et al., “Recombinant chimeric yellow fever-dengue type 2 virus is immunogenic and protective in nonhuman primates,” J. Virol.", "74(12):5477-5485 (2000); S. Tang et al., “Toward a poliovirus-based simian immunodeficiency virus vaccine: correlation between genetic stability and immunogenicity,” J. Virol.", "71(10):7841-7850 (1997)).", "For example, the ChimeriVax-JE vaccine against Japanese encephalitis virus (JEV), which is a genetically engineered derivative of the yellow fever virus vaccine YFV17D in which the genes encoding the structural proteins prM and E of YFV17D are replaced with the corresponding genes of the attenuated JEV SA14-14-2 strain, has been shown to be genetically stable after prolonged passages both in vitro and in vivo (J. Arroyo et al., 2001, supra).", "Another chimeric virus vaccine ChimeriVax-D2 against Dengue virus type 2, which is an attenuated chimeric yellow fever (YF)-dengue type 2 (dengue-2) virus, has also been found to be genetically stable; its sequences were reported to be unchanged after 18 passages in Vero cells (F. Guirakhoo et al., 2000, supra).", "Another preferred vaccine of the present invention utilizes suitable plasmids for delivering the nonpathogenic chimeric DNA clone to pigs.", "In contrast to the traditional vaccine that uses live or killed cell culture propagated whole virus, this invention provides for the direct inoculation of pigs with the plasmid DNA containing the infectious chimeric viral genome.", "Additional genetically engineered vaccines, which are desirable in the present invention, are produced by techniques known in the art.", "Such techniques involve, but are not limited to, further manipulation of recombinant DNA, modification of or substitutions to the amino acid sequences of the recombinant proteins and the like.", "Genetically engineered vaccines based on recombinant DNA technology are made, for instance, by identifying alternative portions of the viral gene encoding proteins responsible for inducing a stronger immune or protective response in pigs (e.g., proteins derived from ORF3, ORF4, etc.).", "Such identified genes or immuno-dominant fragments can be cloned into standard protein expression vectors, such as the baculovirus vector, and used to infect appropriate host cells (see, for example, O'Reilly et al., “Baculovirus Expression Vectors: A Lab Manual,” Freeman & Co., 1992).", "The host cells are cultured, thus expressing the desired vaccine proteins, which can be purified to the desired extent and formulated into a suitable vaccine product.", "If the clones retain any undesirable natural abilities of causing disease, it is also possible to pinpoint the nucleotide sequences in the viral genome responsible for any residual virulence, and genetically engineer the virus avirulent through, for example, site-directed mutagenesis.", "Site-directed mutagenesis is able to add, delete or change one or more nucleotides (see, for instance, Zoller et al., DNA 3:479-488, 1984).", "An oligonucleotide is synthesized containing the desired mutation and annealed to a portion of single stranded viral DNA.", "The hybrid molecule, which results from that procedure, is employed to transform bacteria.", "Then double-stranded DNA, which is isolated containing the appropriate mutation, is used to produce full-length DNA by ligation to a restriction fragment of the latter that is subsequently transfected into a suitable cell culture.", "Ligation of the genome into the suitable vector for transfer may be accomplished through any standard technique known to those of ordinary skill in the art.", "Transfection of the vector into host cells for the production of viral progeny may be done using any of the conventional methods such as calcium-phosphate or DEAE-dextran mediated transfection, electroporation, protoplast fusion and other well-known techniques (e.g., Sambrook et al., “Molecular Cloning: A Laboratory Manual,” Cold Spring Harbor Laboratory Press, 1989).", "The cloned virus then exhibits the desired mutation.", "Alternatively, two oligonucleotides can be synthesized which contain the appropriate mutation.", "These may be annealed to form double-stranded DNA that can be inserted in the viral DNA to produce full-length DNA.", "Genetically engineered proteins, useful in vaccines, for instance, may be expressed in insect cells, yeast cells or mammalian cells.", "The genetically engineered proteins, which may be purified or isolated by conventional methods, can be directly inoculated into pigs to confer protection against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2.An insect cell line (like HI-FIVE) can be transformed with a transfer vector containing nucleic acid molecules obtained from the virus or copied from the viral genome which encodes one or more of the immuno-dominant proteins of the virus.", "The transfer vector includes, for example, linearized baculovirus DNA and a plasmid containing the desired polynucleotides.", "The host cell line may be co-transfected with the linearized baculovirus DNA and a plasmid in order to make a recombinant baculovirus.", "Alternatively, DNA from a pig suffering from PMWS, which encode one or more capsid proteins, the infectious PCV2 molecular DNA clone or the cloned PCV chimeric DNA genome can be inserted into live vectors, such as a poxvirus or an adenovirus and used as a vaccine.", "An immunologically effective amount of the vaccines of the present invention is administered to a pig in need of protection against viral infection or PMWS.", "The immunologically effective amount or the immunogenic amount that inoculates the pig can be easily determined or readily titrated by routine testing.", "An effective amount is one in which a sufficient immunological response to the vaccine is attained to protect the pig exposed to the virus which causes PMWS.", "Preferably, the pig is protected to an extent in which one to all of the adverse physiological symptoms or effects of the viral disease are significantly reduced, ameliorated or totally prevented.", "The vaccine can be administered in a single dose or in repeated doses.", "Dosages may range, for example, from about 1 microgram to about 1,000 micrograms of the plasmid DNA containing the infectious chimeric DNA genome (dependent upon the concentration of the immuno-active component of the vaccine), preferably 100 to 200 micrograms of the chimeric PCV1-2 DNA clone, but should not contain an amount of virus-based antigen sufficient to result in an adverse reaction or physiological symptoms of viral infection.", "Methods are known in the art for determining or titrating suitable dosages of active antigenic agent to find minimal effective dosages based on the weight of the pig, concentration of the antigen and other typical factors.", "Preferably, the infectious chimeric viral DNA clone is used as a vaccine, or a live infectious chimeric virus can be generated in vitro and then the live chimeric virus is used as a vaccine.", "In that case, from about 50 to about 10,000 of the 50% tissue culture infective dose (TCID50) of live chimeric virus, for example, can be given to a pig.", "Desirably, the vaccine is administered to a pig not yet exposed to the PCV virus.", "The vaccine containing the chimeric PCV1-2 infectious DNA clone or other antigenic forms thereof can conveniently be administered intranasally, transdermally (i.e., applied on or at the skin surface for systemic absorption), parenterally, etc.", "The parenteral route of administration includes, but is not limited to, intramuscular, intravenous, intraperitoneal, intradermal (i.e., injected or otherwise placed under the skin) routes and the like.", "Since the intramuscular and intradermal routes of inoculation have been successful in other studies using viral infectious DNA clones (E. E. Sparger et al., “Infection of cats by injection with DNA of feline immunodeficiency virus molecular clone,” Virology 238:157-160 (1997); L. Willems et al., “In vivo transfection of bovine leukemia provirus into sheep,” Virology 189:775-777 (1992)), these routes are most preferred, in addition to the practical intranasal route of administration.", "Although less convenient, it is also contemplated that the vaccine is given to the pig through the intralymphoid route of inoculation.", "A unique, highly preferred method of administration involves directly injecting the plasmid DNA containing PCV1-2 chimera into the pig intramuscularly, intradermally, intralymphoidly, etc.", "When administered as a liquid, the present vaccine may be prepared in the form of an aqueous solution, syrup, an elixir, a tincture and the like.", "Such formulations are known in the art and are typically prepared by dissolution of the antigen and other typical additives in the appropriate carrier or solvent systems.", "Suitable carriers or solvents include, but are not limited to, water, saline, ethanol, ethylene glycol, glycerol, etc.", "Typical additives are, for example, certified dyes, flavors, sweeteners and antimicrobial preservatives such as thimerosal (sodium ethylmercurithiosalicylate).", "Such solutions may be stabilized, for example, by addition of partially hydrolyzed gelatin, sorbitol or cell culture medium, and may be buffered by conventional methods using reagents known in the art, such as sodium hydrogen phosphate, sodium dihydrogen phosphate, potassium hydrogen phosphate, potassium dihydrogen phosphate, a mixture thereof, and the like.", "Liquid formulations also may include suspensions and emulsions that contain suspending or emulsifying agents in combination with other standard co-formulants.", "These types of liquid formulations may be prepared by conventional methods.", "Suspensions, for example, may be prepared using a colloid mill.", "Emulsions, for example, may be prepared using a homogenizer.", "Parenteral formulations, designed for injection into body fluid systems, require proper isotonicity and pH buffering to the corresponding levels of porcine body fluids.", "Isotonicity can be appropriately adjusted with sodium chloride and other salts as needed.", "Suitable solvents, such as ethanol or propylene glycol, can be used to increase the solubility of the ingredients in the formulation and the stability of the liquid preparation.", "Further additives that can be employed in the present vaccine include, but are not limited to, dextrose, conventional antioxidants and conventional chelating agents such as ethylenediamine tetraacetic acid (EDTA).", "Parenteral dosage forms must also be sterilized prior to use.", "Another embodiment of the present invention involves a new method of preparing an infectious, nonpathogenic chimeric nucleic acid molecule of PCV1-2, which comprises removing an open reading frame (ORF) gene of a nucleic acid molecule encoding an infectious nonpathogenic PCV1, replacing the same position with an immunogenic ORF gene of a nucleic acid molecule encoding an infectious pathogenic PCV2, and recovering the chimeric nucleic acid molecule.", "The nucleic acid molecule is typically DNA.", "A preferred method replaces the ORF2 gene of the nonpathogenic PCV1 DNA with the immunogenic ORF2 capsid gene of the infectious pathogenic molecular DNA of PCV2 described herein.", "It is contemplated that other ORF positions or immunogenic fragments thereof can be exchanged between the PCV1 and PCV2 DNA to construct the attenuated infectious chimeric DNA clones according to the methods described herein.", "The recombinant nucleic acid molecule is then used to construct the live, infectious, replicating chimeric virus of the present invention that advantageously retains the nonpathogenic nature of PCV1 yet expresses the immunogenic ORF2 protein of the pathogenic PCV2 and elicits a complete immune response against the pathogenic PCV2.Desirably, the PCV1-2 DNA clone serves as a genetically engineered avirulent, live vaccine against PCV2 infection and PMWS in pigs.", "An infectious DNA clone of PCV2 is constructed, as described herein, so that a biologically pure and homogeneous infectious virus stock can be generated for pathogenesis studies and the development of nonpathogenic, chimeric vaccines.", "The course of clinical disease, virus distribution and pathological lesions associated with PCV2 infection are more definitively characterized by using this molecular DNA clone and a biologically pure and homogeneous infectious PCV2 virus stock derived from the molecular DNA clone than have been observed in the past, which lends itself to the development of the desired vaccine products of the present invention.", "The PCV2 molecular clone is generated by ligating two copies of the complete PCV2 genome in tandem into the pSK vector.", "In sharp contrast to the single copy genome disclosed in the art, the infectious DNA PCV2 clone made by the methods described herein contains two complete copies of the PCV2 genome ligated together in tandem repeat.", "Ligating two copies of genome in tandem provides a similar circular genome that mimics the usual circular genome of PCV2.The advantage of having two copies of the genome in tandem in the infectious DNA PCV2 clone is to be able to maximize replication when the infectious DNA clone is transfected in vitro and in vivo.", "Thus, the clone of the invention operates more efficiently and effectively than the prior single copy genome.", "Infection of animals with the molecular viral clone is extremely useful to studying the genetic determinants of viral replication and virulence in the host.", "Type-2 porcine circovirus (PCV2) has been incriminated as the causative agent of postweaning multisystemic wasting syndrome (PMWS).", "PMWS is a complex disease syndrome in swine and multiple factors may be involved in the clinical presentation of PMWS.", "However, the difficulty in producing a biologically pure form of PCV2 due to the presence of other common swine agents in the tissue homogenates of diseased pigs has impeded a definitive characterization of the clinical disease and pathological lesions solely attributable to PCV2 infection.", "This is the first time an infectious molecular DNA clone of PCV2 has been constructed and used to characterize the disease and pathological lesions associated with PCV2 infection by direct in vivo transfection of pigs with the molecular clone.", "The homogeneous PCV2 live virus stock derived from the molecular clone is shown to be infectious in vitro when transfected into PK-15 cells.", "The cloned PCV2 genomic DNA is also infectious when directly injected into the livers and superficial iliac lymph nodes of specific-pathogen-free (SPF) pigs.", "Animals injected with the cloned PCV2 plasmid DNA develop an infection and disease resembling that induced by intranasal inoculation with a homogenous, infectious PCV2 live virus stock.", "Seroconversion to PCV2-specific antibody is detected in the majority of pigs from the inoculated groups at 35 days postinoculation (DPI).", "The onset and duration of viremia in pigs inoculated with the chimeric PCV1-2 DNA clone are similar to those of the pigs inoculated with the nonpathogenic PCV1 DNA clone, whereas viremia in pigs inoculated with the PCV2 clone appears earlier and lasted longer.", "Beginning at 14 DPI and lasting about 2-4 weeks, viremia is detected in the majority of the PCV2-inoculated animals.", "Similarly, the majority of inoculated pigs necropsied at 35 DPI seroconverted to PCV2-antibodies.", "PCV2 antigen is detected in various tissues and organs in inoculated pigs.", "Gross lesions are limited to the lungs and lymph nodes, and are characterized by systematically enlarged tan colored lymph nodes, lungs that failed to collapse and mild multifocal tan-colored foci of consolidation.", "Gross lesions affecting the lymph nodes in both the nonpathogenic PCV1 and the chimeric PCV1-2 inoculated pigs are mild and limited to only a few animals, whereas the pathogenic PCV2 inoculated pigs all have moderate-to-severe swelling and discoloration of lymphoid tissues (Table 9, below).", "Statistical analysis reveals that the scores of the gross lesions in the lymph nodes of the chimeric PCV1-2 inoculated animals are similar to those in nonpathogenic PCV1 inoculated pigs.", "At 21 DPI, PCV2 inoculated pigs have gross lesions that are statistically more severe than those of the PCV1 and the chimeric PCV1-2 inoculated pigs.", "Histopathological lesions and PCV2-specific antigen are detected in numerous tissues and organs including brain, lung, heart, kidney, tonsil, lymph nodes, spleen, ileum and liver of the inoculated (infected) pigs.", "The histopathological lesions in multiple tissues and organs similar to those of PMWS are reproduced with the PCV2 molecular DNA clone as well as with the infectious virus prepared in vitro from the molecular DNA clone.", "Microscopically, at both 21 and 49 DPIs, the chimeric PCV1-2 inoculated animals have statistically less microscopic lesions than the PCV2 inoculated animals.", "The microscopic lesion scores in lymph nodes of the chimeric PCV1-2 inoculated pigs are similar to those of the nonpathogenic PCV1, the reciprocal chimeric PCV2-1 and the uninoculated control animals.", "Moderate to severe microscopic lesions are found in multiple tissues of pathogenic PCV2 inoculated animals including lung, liver, lymphoid, spleen, brain, heart, kidney and tonsil tissue.", "However, in chimeric PCV1-2 inoculated animals, mild to moderate microscopic lesions are limited only to liver, lymph nodes and kidney tissues (see Table 10, below).", "There are no remarkable clinical signs of PMWS in the control or any of the inoculated pigs.", "Although the characteristic clinical symptoms of PMWS are not observed with the cloned PCV2 plasmid DNA (the infectious PCV2 DNA clone) or with a biologically pure PCV2 infectious virus stock, PCV2 is clearly responsible for the PMWS-like histopathological lesions reproduced in the below illustrative examples.", "It is generally believed that PCV2 is the primary but not the sole pathogenic agent responsible for the onset of clinical PMWS.", "This invention more definitively characterizes the clinical course and pathological lesions exclusively attributable to PCV2 infection.", "The present data in the below illustrative examples indicate that the readily reproduced, cloned PCV2 genomic DNA is available to replace infectious virus for the PCV2 pathogenesis and immunization studies.", "While PCV2 is shown as essential for development of PMWS, other factors or agents such as PRRSV, PPV, etc.", "may be required to induce the full spectrum of clinical signs and lesions associated with advanced cases of PMWS.", "However, with the knowledge that PCV2 is a key factor, the novel infectious, replicating viral clone of the present invention can be further modified or genetically engineered to achieve the desired optimal immunogenic effect through methods known to those of ordinary skill in immunology and molecular genetics.", "The availability of the infectious DNA clone of PCV2 described herein makes it feasible to develop the genetically engineered attenuated vaccine for preventing PCV2 infection and PMWS in pigs.", "It is known that PCV2 replicates in the lymph nodes, lungs and liver during natural infection, and one of the major pathogenic effects is the impairment of the immune system by degradation of the lymphoid structures (S. Krakowka et al., 2001, supra; G. M. Allan and J.", "A. Ellis, 2000, supra; S. Kennedy et al., 2000, supra; G. J. Wellenberg et al., 2000, supra; G. M. Allan et al., “Experimental reproduction of severe wasting disease by co-infection of pigs with porcine circovirus and porcine parvovirus,” J. Comp.", "Pathol.", "121:1-11 (1999); J. Ellis et al., “Reproduction of lesions of postweaning multisystemic wasting syndrome in gnotobiotic piglets,” J. Vet.", "Diagn.", "Invest.", "11:3-14 (1999); J. C. Harding and E. G. Clark, 1997, supra).", "By using this novel infectious PCV2 molecular DNA clone, the clinical disease, pathological lesions and virus distribution exclusively attributable to PCV2 infection are more definitively characterized.", "The structural and functional relationships of the PCV genes are better understood due to the availability of the PCV2, PCV1, chimeric PCV1-2, and reciprocal chimeric PCV2-1 infectious DNA clones described herein.", "Will et al., “Cloned HBV DNA causes hepatitis in chimpanzees,” Nature 299:740-742 (1982), first demonstrated the feasibility of using a cloned hepatitis B virus DNA to infect chimpanzees by direct in vivo injection.", "This approach has since been used to study viral replication and pathogenesis of several other viruses (T. W. Dubensky et al., “Direct transfection of viral and plasmid DNA into the liver or spleen of mice,” Proc.", "Natl.", "Acad.", "Sci.", "USA 81:7529-7533 (1984); R. Girones et al., “Complete nucleotide sequence of a molecular clone of woodchuck hepatitis virus that is infectious in the natural host,” Proc.", "Natl.", "Acad.", "Sci.", "USA 86:1846-1849 (1989); N. L. Letvin et al., “Risks of handling HIV,” Nature 349:573 (1991); C. Seeger et al., “The cloned genome of ground squirrel hepatitis virus is infectious in the animal.", "Proc.", "Natl.", "Acad.", "Sci.", "USA.", "81:5849-5852 (1984); E. E. Sparger et al., “Infection of cats by injection with DNA of feline immunodeficiency virus molecular clone,” Virology 238:157-160 (1997); R. Sprengel et al., “Homologous recombination between hepadnaviral genomes following in vivo DNA transfection: implications for studies of viral infectivity,” Virology 159:454-456 (1987); H. Will et al., 1982, supra; L. Willems et al., “In vivo transfection of bovine leukemia provirus into sheep,” Virology 189:775-777 (1992)).", "The construction of an infectious PCV2 molecular DNA clone, and the demonstration of infection by direct injection of cloned PCV2 plasmid DNA into the liver and lymph nodes of pigs in the context of the present invention are advantageous for PCV2 studies.", "This in vivo transfection system will enhance the study of the structural and functional relationship of PCV2 genes using recombinant plasmids constructed in vitro to test different regions or genes of PCV2 for their roles in virus replication and pathogenesis in the host.", "The replication and pathogenesis of PCV2 can be studied in vivo without having to produce infectious virus stocks by propagating PCV2 in cell cultures.", "This is advantageous as serial cell culture passages may select for viral variants.", "Another advantage of using cloned PCV2 genomic DNA, instead of live virus, for animal studies is its relative ease for quantitation of the inoculation dose.", "The amount of the cloned PCV2 DNA used for animal inoculation can be easily determined by a spectrophotometer, whereas the dose of live PCV2 virus requires infectivity titration in cell cultures and confirmation of infection by IFA.", "Direct injection of animals with cloned PCV2 plasmid DNA eliminates the problems associated with the presence of other indigenous swine agents in tissue homogenate inocula in animal studies.", "In the present invention, the immunogenic ORF2 capsid gene is switched between the pathogenic PCV2 and the nonpathogenic PCV1 to produce the unique structure of the chimeric PCV1-2 infectious DNA clone.", "Surprisingly and advantageously, the chimeric PCV1-2 infectious clone replicated, expressed the immunogenic ORF2 capsid antigen in vitro and in vivo, and induced a specific antibody response against PCV2 ORF2 but retained the nonpathogenic nature of PCV1.The chimeric PCV1-2 infectious DNA clone has the ability to induce a strong immune response against PCV2 while inducing only a limited infection with mild pathologic lesions similar to that of the nonpathogenic PCV1.For vaccine development, the relatively easy storage and stability of cloned DNA, and the economy of large-scale recombinant PCV2 plasmid DNA and chimeric PCV1-2 DNA clone production provides an attractive means of delivering a live, infectious viral DNA vaccine or genetically engineered, attenuated viral vaccines to pigs.", "Therefore, the chimeric PCV1-2 infectious DNA clone taught in this invention is a useful vaccine candidate against PCV2 infection and PMWS.", "It should be appreciated that all scientific and technological terms used herein have the same meaning as commonly understood by those of ordinary skill in the art.", "For purposes of this invention, the term “infectious” means that the virus replicates in pigs, regardless of whether or not the virus causes any diseases.", "“SPF” refers to Specific-pathogen-free pigs.", "The “gnotobiotic” pigs intend germ-free pigs.", "The terms “PCV2 plasmid DNA,” “PCV2 genomic DNA” and “PCV2 molecular DNA” are being used interchangeably to refer to the same cloned nucleotide sequence.", "The infectious PCV1/PCV2 chimeric DNA clone (strain designation “PCV1-2 chimera”), the infectious PCV2 molecular DNA clone (strain designation “PCV2 clone”) and the biologically pure and homogeneous PCV2 stock derived from an Iowa sample of PCV2 that had been isolated from a pig with severe PMWS and identified as isolate number 40895 (strain designation “PCV2 #40895”) are deposited under the conditions mandated by 37 C.F.R.", "§ 1.808 and maintained pursuant to the Budapest Treaty in the American Type Culture Collection (ATCC), 10801 University Boulevard, Manassas, Va. 20110-2209, U.S.A.", "The DNA sequences described herein are contained within 6,490 bp plasmids cloned into pBluescript SK(+) vector (pSK) (Stratagene Inc., La Jolla, Calif.) and transformed into Escherichia coli DH5a competent cells.", "The plasmids containing the infectious chimeric PCV1-2 DNA clone (identified as “chimeric porcine circovirus Type 1 (PCV1) and Type 2 (PCV2) infectious DNA clone”) and the infectious PCV2 molecular DNA clone (identified as “infectious DNA clone of Type 2 porcine circovirus (PCV2)”) have been deposited in the ATCC on Dec. 7, 2001 and have been assigned ATCC Patent Deposit Designations PTA-3912 and PTA-3913, respectively.", "It should be appreciated that other plasmids, which may be readily constructed using site-directed mutagenesis and the techniques described herein, are also encompassed within the scope of the present invention.", "The biologically pure and homogeneous PCV2 sample of isolate number 40895 (identified as “Type 2 porcine circovirus (PCV2)”) has also been deposited in the ATCC on Dec. 7, 2001 and has been assigned ATCC Patent Deposit Designation PTA-3914.The genomic (nucleotide) sequence of the PCV2 isolate number 40895 has been deposited with the Genbank database and has been publicly available since Jul.", "23, 2000 under accession number AF264042.The following examples demonstrate certain aspects of the present invention.", "However, it is to be understood that these examples are for illustration only and do not purport to be wholly definitive as to conditions and scope of this invention.", "It should be appreciated that when typical reaction conditions (e.g., temperature, reaction times, etc.)", "have been given, the conditions both above and below the specified ranges can also be used, though generally less conveniently.", "The examples are conducted at room temperature (about 23° C. to about 28° C.) and at atmospheric pressure.", "All parts and percents referred to herein are on a weight basis and all temperatures are expressed in degrees centigrade unless otherwise specified.", "A further understanding of the invention may be obtained from the non-limiting examples that follow below.", "Example 1 Generation of a PK-15 Cell Line Free of PCV1 Contamination The source of the PCV2 isolate was from a spleen tissue sample of a pig with naturally occurring PMWS (PCV2 serial identification number 40895, referred to as “isolate 40895”) (M. Fenaux et al., 2000, supra).", "Immunohistochemical staining (IHC) with PCV2-specific antibody confirmed the presence of PCV2 antigen in the tissue.", "The spleen tissues were stored at −80° C. until use.", "The PK-15 cell line purchased from the American Type Culture Collection (ATCC accession number CCL-33) was persistently infected with PCV1 (G. C. Dulac and A. Afshar, 1989, supra).", "Since only a subpopulation of PK-15 cells was persistently infected (id.", "), a PK-15 cell line that is free of PCV1 contamination by end-point dilution was generated.", "Protocol proceeded as follows: PK-15 cells were grown in MEM with Earle's salts and L-glutamine (Life Technologies, Inc., Grand Island, N.Y.) supplemented with 10% fetal bovine serum (FBS) and 1× antibiotic (Life Technologies, Inc.).", "Confluent cell monolayers were trypsinized, and the cells were then counted and serially diluted to an end point with one cell per 0.2 ml.", "The end point dilution was plated in 96-well plates and allowed to grow into a monolayer starting from a single cell.", "Cells from each well were tested for PCV1 DNA using a PCR-RFLP assay capable of detecting and differentiating PCV1 and PCV2 (M. Fenaux et al., 2000, supra).", "PK-15 cells from wells that were tested negative for PCV1 by the PCR-RFLP assay were subsequently expanded.", "The PCV1 free PK-15 cell line was subcultured five additional passages and was found negative for PCV1 DNA by PCR at each passage.", "Four cell lines that were negative for PCV1 contamination were produced by the end-point dilution of the persistently infected PK-15 cells from ATCC.", "The cell lines remained negative for PCV1 by PCR after the five additional passages.", "One of the cell lines was subsequently expanded and was shown to be able to support PCV2 replication when the cells were transfected with the PCV2 molecular DNA clone (FIG.", "2) and infected with PCV2 virus.", "The cloned cells were further used for the in vitro transfection of PCV2 molecular DNA clone to generate a biologically pure PCV2 infectious virus stock for the animal inoculation experiment.", "Example 2 Construction of the PCV2 Infectious DNA Clone To construct a PCV2 molecular DNA clone, a pair of PCR primers was designed according to the published sequence of the PCV2 isolate 40895 (M. Fenaux et al., 2000, supra): forward primer F-PCVSAC2 (5′-GAACCGCGGGCTGGCTGAACTTTTGAAAGT-3′), set forth in SEQ ID NO:5, and reverse primer R-PCVSAC2 (5′-GCACCGCGGAAATTTCTGACAAACGTTACA-3′), set forth in SEQ ID NO:6.This pair of primers amplifies the complete genome of PCV2 with an overlapping region containing the unique SacII restriction enzyme site (FIG.", "1).", "DNA was extracted using the QIAamp DNA Minikit (Qiagen, Inc., Valencia, Calif.) from a spleen tissue sample of a pig with naturally occurring PMWS (isolate 40895) (M. Fenaux et al., 2000, supra).", "The extracted DNA was amplified by PCR with AmpliTaq Gold polymerase (Perkin-Elmer, Norwalk, Conn.).", "The PCR reaction consisted of an initial enzyme activation step at 95° C. for 9 min, followed by 35 cycles of denaturation at 94° C. for 1 min, annealing at 48° C. for 1 min, extension at 72° C. for 3 min, and a final extension at 72° C. for 7 min.", "The PCR product of expected size was separated by gel electrophoresis and purified with the glassmilk procedure with a Geneclean Kit (Bio 101, Inc., La Jolla, Calif.).", "To construct a molecular DNA clone containing a tandem dimer of PCV2 genome, the PCR product containing the complete PCV2 genome was first ligated into the advanTAge plasmid vector (Clontech, Palo Alto, Calif.).", "E. Coli DH5a competent cells were transformed.", "The recombinant plasmids were verified by restriction enzyme digestion.", "The full length PCV2 genomic DNA was excised from the advanTAge vector by digestion with SacII restriction enzyme.", "The digested PCV2 genomic DNA was ligated with T4 DNA ligase at 37° C. for only 10 min, which favors the production of tandem dimers.", "The tandem dimers were subsequently cloned into pBluescript SK(+) vector (pSK) (Stratagene Inc., La Jolla, Calif.) (FIG.", "1).", "Recombinant plasmids containing tandem dimers of PCV2 genome (herein referred to as PCV2 molecular DNA clone) were confirmed by PCR, restriction enzyme digestion, and DNA sequencing.", "The DNA concentration of the recombinant plasmids was determined spectrophotometrically.", "Specifically, the complete genome of the PCV2 (isolate 40895) was amplified by PCR to construct the infectious PCV2 molecular DNA clone.", "Two copies of the complete PCV2 genome were ligated in tandem into the pSK vector to produce the PCV2 molecular DNA clone (FIG.", "1).", "The infectivity of the PCV2 molecular DNA clone was determined by in vitro transfection of the PK-15 cells.", "IFA with PCV2-specific antibody confirmed that the molecular DNA clone is infectious in vitro and that about 10-15% of the PK-15 cells were transfected.", "PCV2-specific antigen was visualized by IFA in the nucleus, and to a lesser degree, cytoplasm of the transfected cells (FIG.", "2).", "The cells mock-transfected with the empty pSK vector remained negative for PCV2 antigen.", "Example 3 In Vitro Transfection with the PCV2 Molecular DNA Clone and Generation of a Biologically Pure and Homogenous PCV2 Infectious Virus Stock To test the infectivity of the molecular DNA clone in vitro, PK-15 cells free of PCV1 contamination were grown in 8-well LabTek chamber slides.", "When the PK-15 cells reached about 85% confluency, cells were transfected with the molecular DNA clone using Lipofectamine Plus Reagents according to the protocol supplied by the manufacturer (Life Technologies, Inc).", "Mock-transfected cells with empty pSK vector were included as controls.", "Three days after transfection, the cells were fixed with a solution containing 80% acetone and 20% methanol at 4° C. for 20 min., and an immunofluorescence assay using a PCV2-specific rabbit polyclonal antisera was performed to determine the in vitro infectivity of the molecular DNA clone (see below).", "To generate a biologically pure and homogeneous PCV2 infectious virus stock for the animal inoculation experiment, PK-15 cells free of PCV1 contamination were cultivated in T-25 culture flasks and transfected with the PCV2 molecular DNA clone.", "PK-15 cells were grown to about 85% confluency in T-25 flasks.", "The cells were washed once with sterile PBS buffer before transfection.", "For each transfection reaction in a T-25 flask, 12 μg of the PCV2 plasmid DNA was mixed with 16 μl of Plus Reagent in 0.35 ml of MEM media.", "A flask of mock-transfected cells with empty pSK vector was included as the negative control.", "After incubation at room temperature for 15 min., 50 μl of Lipofectamine Reagent diluted in 0.35 ml of MEM media was added to the mixture and incubated at room temperature for another 15 min.", "The transfection mixture was then added to a T-25 flask of PK-15 cells containing 2.5 ml of fresh MEM.", "After incubation at 37° C. for 3 hrs, the media was replaced with fresh MEM media containing 2% FBS and 1× antibiotics.", "The transfected cells were harvested at 3 days post transfection and stored at −80° C. until use.", "The infectious titer of the virus stock was determined by IFA (see below).", "Basically, biologically pure and homogenous PCV2 infectious virus stock was generated by transfection of PK-15 cells with the PCV2 molecular DNA clone.", "PCV2 virions produced by in vitro transfection were infectious since the transfected cell lysates were successfully used to infect PK-15 cells.", "Thus, the PCV2 molecular DNA clone is capable of producing infectious PCV2 virions when transfected in vitro.", "The infectious titer of the homogenous PCV2 virus stock prepared from transfected cells was determined to be 1×104.5 TCID50/ml.", "This virus stock was used to inoculate pigs in Group 2.Lysates of cells mock-transfected with the empty pSK vector were unable to infect PK-15 cells.", "Example 4 Virus Titration by Immunofluorescence Assay (IFA) To determine the infectious titer of the homogenous PCV2 virus stock, PK-15 cells were cultivated on 8-well LabTek chamber slides.", "The virus stock was serially diluted 10-fold in MEM, and each dilution was inoculated onto 10 wells of the monolayers of the PK-15 cells growing on the LabTek chamber slides.", "Wells of non-inoculated cells were included as controls.", "The infected cells were fixed at 3 days post inoculation with a solution containing 80% acetone and 20% methanol at 4° C. for 20 min.", "After washing the cells with PBS buffer, the infected cells were incubated with a 1:1,000 diluted PCV2-specific rabbit polyclonal antibody (S. D. Sorden et al., “Development of a polyclonal-antibody-based immunohistochemical method for the detection of type 2 porcine circovirus in formalin-fixed, paraffin-embedded tissue,” J. Vet.", "Diagn.", "Invest.", "11:528-530 (1999)) at 37° C. for 1 hr.", "The cells were then washed three times with PBS buffer, and incubated with a secondary FITC-labeled goat anti-rabbit IgG (Kirkegaard & Perry Laboratories Inc, Gaithersburg, Md.)", "at 37° C. for 45 min.", "After washing the slides three times with PBS buffer, and the slides were mounted with fluoromount-G, cover-slipped and examined under a fluorescence microscope.", "The 50% tissue culture infectious dose per ml (TCID50/ml) was calculated.", "Initially, cells were transfected with a plasmid construct containing a single copy of PCV2 genome but the infectious PCV2 titer from the single genome construct is much lower than the one containing the tandem genome.", "Therefore, the plasmid construct containing the dimeric form of PCV2 genome was used for the in vitro and in vivo transfection experiments.", "Example 5 In Vivo Transfection of Pigs with the PCV2 Molecular DNA Clone and Experimental Inoculation of Pigs with the Homogeneous PCV2 Infectious Virus Stock Forty specific-pathogen-free (SPF) swine of 4 weeks of age were randomly assigned into 4 rooms of 10 animals each.", "Prior to inoculation, the SPF pigs were tested for antibodies to PCV, PRRSV, PPV and swine hepatitis E virus.", "Pigs in Group 1 were uninoculated and served as negative controls.", "Pigs in Group 2 were each inoculated intranasally with about 1.9×105 TCID50 of the PCV2 infectious virus stock derived from the PCV2 molecular DNA clone.", "Pigs in Group 3 received direct intrahepatic injection of the recombinant plasmid DNA of the PCV2 molecular clone.", "Each pig was injected with a total of 200 μg of recombinant plasmid DNA (the cloned PCV2 plasmid DNA), through an ultrasound-guided technique, into 6 different sites of the liver.", "Pigs in Group 4 were each injected with a total of 200 μg of the recombinant PCV2 plasmid DNA directly into the superficial iliac lymph nodes, and each lymph node received two separate injections.", "The animals were monitored daily for clinical signs of disease.", "Serum samples were collected from each animal at 0, 7, 14, 21, 28, 35 days post inoculation (DPI).", "At 21 DPI, five pigs were randomly selected from each group and necropsied.", "The remaining five animals in each group were necropsied at 35 DPI.", "Various tissues and organs were collected during necropsy and processed for histological examination and immunohistochemical staining (see below).", "The results are shown in Table 1 below.", "All inoculated pigs from Groups 2, 3 and 4 were negative for PCV2 antibodies at 0 DPI.", "Two pigs in the uninoculated control Group 1 had detectable PCV2 maternal antibody at 0 DPI.", "The maternal antibody in these two piglets waned by 7 DPI.", "No seroconversion to PCV2 antibody was detected in any of the 10 uninoculated control pigs.", "In Group 2 pigs intranasally inoculated with PCV2 infectious virus, 1 piglet seroconverted to PCV2 antibody at 21 DPI.", "By 35 DPI, 4 of the 5 remaining Group 2 pigs had seroconverted.", "Seroconversion in transfected animals from Groups 3 and 4 first appeared at 28 DPI.", "By 35 DPI, 5 of 5 remaining pigs from Group 3 and 3 of 5 remaining pigs from Group 4 had seroconverted to PCV2 antibody.", "PPV antibodies were tested at 3 and 21 DPI for all pigs, and at 35 DPI for the remaining pigs.", "Maternal antibodies to the ubiquitous swine agent PPV were detected in the SPF piglets.", "The PPV HI antibody titers in all piglets but one decreased significantly from 3 DPI (an average titer of 1:2,665) to 21 DPI (an average titer of 1:246), indicating the antibody detected in these piglets was passively derived.", "One piglet had a slightly increased PPV HI titer from 1:32 at 3 DPI to 1:64 at 21 DPI, which is likely due to testing variation.", "Serum samples collected from all pigs at 0, 21, and 35 DPI were further tested for PPV DNA with a published PCR assay (J. M. Soucie et al., “Investigation of porcine parvovirus among persons with hemophilia receiving Hyate: C porcine factor VIII concentrate,” Transfusion 40:708-711 (2000)).", "No PPV viremia was detected from any pigs at any DPI, further indicating the pigs were not infected by PPV.", "TABLE 1 Seroconversion to PCV2 Specific Antibodies in Pigs Inoculated With PCV2 Live Virus or Directly Injected With Cloned PCV2 Plasmid DNA Route of Days Postinoculation Group Inocula Inoculation 0 7 14 21 28 35 1 None 2/10a 0/10 0/10 0/10 0/5 0/5 2 PCV2 live virusb Intranasal 0/10 0/10 0/10 1/10 1/5 4/5 3 PCV2 DNAc Intrahepatic 0/10 0/10 0/10 0/10 1/5 5/5 4 PCV2 DNAc Intralymphoid 0/10 0/10 0/10 0/10 1/5 3/5 aPCV2 antibody was measured with an ELISA, number positive/number tested.", "bA biologically pure and homogeneous PCV2 virus stock generated by transfection of PK-15 cells with PCV2 molecular DNA clone.", "cCloned PCV2 genomic DNA in pSK plasmid.", "Example 6 PCR-RFLP Analyses To measure PCV2 viremia in pigs transfected with PCV2 molecular DNA clone and in pigs infected with PCV2 infectious virus stock, serum samples collected at different DPIs were tested for the presence of PCV2 DNA by the general methods of a PCR-RFLP assay previously described (M. Fenaux et al., 2000, supra).", "Viral DNA was extracted from 50 μl of each serum sample using the DNAzol® reagent according to the protocol supplied by the manufacturer (Molecular Research Center, Cincinnati, Ohio).", "The extracted DNA was resuspended in DNase-, RNase-, and proteinase-free water and tested for PCV2 DNA by PCR-RFLP (id.).", "PCR products from selected animals were sequenced to verify the origin of the virus infecting pigs.", "Serum samples were collected from all control and inoculated animals at 0, 7, 14, 21, 28, and 35 DPIs and assayed for PCV2 viremia by detection of PCV2 DNA (id.).", "The results are shown in Table 2 below.", "PCV2 DNA was not detected in the Group 1 uninoculated control pigs at any DPI.", "Viremia was detected in 7/10 pigs from Group 2 at 14 DPI and 8/10 by 35 DPI.", "Viremia lasted only a few weeks as the PCV2 DNA was not detectable at 28 DPI and 35 DPI in all 5 remaining pigs from Group 2.In Group 3 pigs that were intrahepatically injected with PCV2 molecular DNA clone, 8/10 pigs were viremic at 14 DPI, and 9/10 pigs had detectable viremia by 35 DPI.", "Group 4 pigs were injected with PCV2 molecular DNA clone into the lymph nodes.", "Two of 10 pigs at 14 DPI and 8 of 10 pigs at 21 DPI from Group 4 were viremic.", "The results show that PCV2 molecular DNA clone is infectious when injected directly into the liver and superficial iliac lymph nodes of SPF pigs.", "PCR products amplified from selected animals were sequenced.", "The sequence of the PCR products amplified from selected animals was identical to the corresponding region of the PCV2 molecular DNA clone.", "TABLE 2 Detection of Viremia (PCV2 DNA) by PCR in Sera of Inoculated and Control Pigs Route of Days Postinoculation Group Inocula Inoculation 0 7 14 21 28 35 Total 1 None 0/10a 0/10 0/10 0/10 0/5 0/5 0/10 2 PCV2 live virusb Intranasal 0/10 0/10 7/10 5/10 0/5 0/5 8/10 3 PCV2 DNAc Intrahepatic 0/10 0/10 8/10 6/10 3/5 3/5 9/10 4 PCV2 DNAc Intralymphoid 0/10 0/10 2/10 8/10 2/5 0/5 8/10 a10 pigs in each group, number positive/number tested.", "bA biologically pure and homogeneous PCV2 virus stock generated by transfection of PK-15 cells with PCV2 molecular DNA clone.", "cCloned PCV2 genomic DNA in pSK plasmid.", "Example 7 Clinical Evaluation Pigs were weighed on 0 DPI and at the time of necropsy.", "Rectal temperatures and clinical respiratory disease scores, ranging from 0 to 6 (0=normal, 6=severe) (P. G. Halbur et al., “Comparison of the pathogenicity of two U.S. porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus,” Vet.", "Pathol.", "32:648-660 (1995)), were recorded every other day from 0 to 35 DPI.", "Clinical observations including evidence of central nervous system disease, liver disease (icterus), musculoskeletal disease, and changes in body condition, were also recorded daily.", "To evaluate the gross pathology and histopathology, five pigs from each group were randomly selected for necropsies at 21 and 35 DPI.", "The necropsy team was blinded to infection status of the pigs at necropsy.", "Complete necropsies were performed on all pigs.", "An estimated percentage of the lung with grossly visible pneumonia was recorded for each pig based on a previously described scoring system (id).", "The scoring system is based on the approximate volume that each lung lobe contributes to the entire lung: the right cranial lobe, right middle lobe, cranial part of the left cranial lobe, and the caudal part of the left cranial lobe each contribute 10% of the total lung volume, the accessory lobe contributes 5%, and the right and left caudal lobes each contribute 27.5%.", "Other lesions such as enlargement of lymph nodes were noted separately.", "Sections for histopathologic examination were taken from nasal turbinate, lungs (seven sections) (id.", "), heart, brain, lymph nodes (tracheobronchial, iliac, mesenteric, subinguinal), tonsil, thymus, liver, gall bladder, spleen, joints, small intestine, colon, pancreas, and kidney.", "The tissues were examined in a blinded fashion and given a subjective score for severity of lung, lymph node, and liver lesions.", "Lung scores ranged from 0 (normal) to 3 (severe lymphohistiocytic interstitial pneumonia).", "Liver scores ranged from 0 (normal) to 3 (severe lymphohistiocytic hepatitis).", "Lymph node scores were for an estimated amount of lymphoid depletion of follicles ranging from 0 (normal or no lymphoid depletion) to 3 (severe lymphoid depletion and histiocytic replacement of follicles).", "The serology protocol involved collecting blood on arrival at 11 to 12 days of age, and from all pigs at 0, 7, 14, 21, 28, and 35 DPIs.", "Serum antibodies to PRRSV were assayed using Herd Check PRRSV ELISA (IDEXX Laboratories, Westbrook, Mass.).", "Serum antibodies to PPV were detected by a hemagglutination inhibition (HI) assay (H. S. Joo et al., “A standardized haemagglutination inhibition test for porcine parvovirus antibody,” Aust.", "Vet.", "J.", "52:422-424 (1976)).", "Serum antibodies to PCV2 were detected by a modified indirect ELISA based on the recombinant ORF2 protein of PCV2 (P. Nawagitgul et al., “Modified indirect porcine circovirus (PCV) type 2-based and recombinant capsid protein (ORF2)-based ELISA for the detection of antibodies to PCV,” Immunol.", "Clin.", "Diagn.", "Lab Immunol.", "1:33-40 (2002)).", "A partially purified PCV2 antigen was prepared from Hi Five cells (Invitrogen, Carlsbad, Calif.) infected with recombinant baculovirus containing the major capsid ORF2 protein of PCV2 (P. Nawagitgul et al., “Open reading frame 2 of porcine circovirus type 2 encodes a major capsid protein,” J. Gen. Virol.", "81:2281-2287 (2000)).", "Cell lysates of Hi Five cells infected with wild-type baculovirus were prepared similarly and served as negative control antigen.", "The Immulon 2 HB polystyrene microtiter plates (Dynex Technologies Inc, Chantilly, Va.) were coated with optimal concentrations of positive and negative antigens at 4° C. for 36 hrs.", "One hundred μl of each serum sample diluted 1:100 in 5% milk diluent (Kirkegaard & Perry Laboratories, Inc.) was added into each well.", "The serum samples were tested in quadruplicate: 2 wells for negative control antigen and 2 parallel wells for PCV2 antigen.", "Positive control and negative control sera were included in each plate.", "The sera were incubated at 37° C. for 30 min.", "and then washed 5 times with 0.1 M PBS buffer containing 0.1% Tween-20.A peroxidase-labeled secondary anti-swine IgG (Sigma Co, St. Louis, Mo.)", "was incubated at 37° C. for 30 min.", "The plates were washed again and incubated with 2,2′-azino-di-(3-ethylbenzthiazoline-6-sulfonate) (Kirkegaard & Perry Laboratories Inc) at 37° C. for 15 min.", "for color development.", "The optical density (OD) was read at 405 nm.", "The corrected OD of each tested and control sera was calculated by subtraction of mean OD value of the wells containing negative antigen from that of the parallel wells containing PCV2 antigen.", "The data was normalized by dividing the corrected OD value of a tested serum sample (S) with that of the positive control serum (P) and reported as S/P ratios.", "The samples with S/P ratios ≤0.12, 0.12 to 0.2, and >0.2 were considered as negative, equivocal and positive, respectively.", "From the results of the clinical evaluation, none of the control and inoculated pigs showed obvious signs of disease resembling those of clinical PMWS.", "There was no difference in weight gain or mean rectal temperatures between any of the four groups.", "The control pigs of Group 1 remained normal throughout the experiment.", "There was mild transient respiratory disease observed in the majority of the pigs in PCV2 DNA-transfected and PCV2 virus-infected groups from 8 to 14 DPI.", "This was characterized by mild dyspnea (clinical respiratory scores of 1 to 2) of one-to-two days duration in individual pigs and 5-6 days duration for the group.", "There were no gross lesions observed in the control pigs at necropsy.", "Pigs in the three inoculated groups had gross lesions limited to the lungs and lymph nodes (see Table 3, below).", "The lesions were similar among pigs in the PCV2 plasmid DNA-transfected and PCV2 virus-infected groups.", "Lungs failed to collapse and had random, multifocal, moderately well-demarcated areas of tan-to-purple consolidation involving 0-2% of the lung (FIG.", "3) at 21 DPI, and 0-13% of the lung at 35 DPI.", "Lymph nodes were systemically enlarged 2 to 5 times normal size, firm, and tan (FIG.", "3) at both 21 and 35 DPI in most of the pigs from all three PCV2-inoculated groups.", "Microscopic examination revealed no lesions in any tissues of the control pigs except for the livers.", "Eight of ten control pigs had very mild multifocal lymphoplasmacytic inflammation predominately in the periportal regions of the liver as is commonly observed in normal pigs and considered normal background (P. G. Halbur et al., 2001, supra).", "Pigs from the two PCV2 plasmid DNA-transfected groups (intrahepatic and intralymphoid) and the PCV2 virus-infected group (intranasal) had similar lesions in brain, lung, heart, kidney, lymphoid tissues (tonsil, lymph nodes, spleen), ileum, and liver (see Table 4, below).", "Brain lesions were observed in 23/30 of the pigs from the three inoculated groups and were characterized as mild-to-moderate multifocal lymphoplasmacytic meningoencephalitis with perivascular cuffing and gliosis.", "Lung lesions were observed in 28/30 PCV2-inoculated pigs and characterized as mild-to-moderate peribronchiolar lympho-plasmacytic and histiocytic bronchointerstitial pneumonia (FIG.", "3C).", "One pig from the PCV2 virus-infected Group 2 necropsied at 21 DPI, and one pig each from the two PCV2 plasmid DNA-transfected groups necropsied at 35 DPI had ulcerative and proliferative bronchiolitis with fibroplasia and granulomatous inflammation in the lamina propria and peribronchiolar regions of bronchi.", "Mild multifocal lymphoplasmacytic myocarditis was also observed in 18/30 PCV2-inoculated pigs.", "In 14/30 of the PCV2-inoculated pigs, mild-to-moderate multifocal lymphoplasmacytic interstitial nephritis was observed.", "No lesions were observed in the thymuses.", "Mild-to-moderate lymphoid depletion (FIG.", "4B) and histiocytic replacement of follicles was observed in the tonsil of 8/30, in the spleen of 7/30, and in the lymph nodes of 26/30 of the PCV2-inoculated pigs.", "Moderate granulomatous lymphadenitis with giant cells (FIG.", "4C) was observed at 21 DPI in three pigs inoculated intranasally with PCV2 virus, and in one pig at 35 DPI in each of the PCV2 plasmid DNA-transfected groups.", "Mild lymphoplasmacytic and histiocytic enterocolitis were observed in 3/5 pigs in the PCV2 virus-infected group, in 3/5 pigs in the PCV2 plasmid DNA intrahepatically-transfected group, and 1/5 pigs in the PCV2 plasmid DNA intralymphoid-transfected group at 35 DPI.", "One pig in each of the PCV2 plasmid DNA-transfected groups had mild lymphoid depletion with histiocytic replacement and low numbers of giant cells in the Peyer's patches.", "Mild-to-moderate lymphoplasmacytic hepatitis was observed in 29/30 of the three PCV2-inoculated pigs.", "Low numbers of widely scattered individually necrotic hepatocytes surrounded by lymphohistiocytic inflammation was observed in one pig in each of the PCV2 plasmid DNA-transfected groups at 21 DPI.", "Lesions in other tissues were unremarkable.", "Microscopic lesions in the lung, liver and lymph nodes were scored according to published scoring systems (Table 4, below) (P. G. Halbur et al., 2001, supra; P. G. Halbur et al., 1995, supra).", "There were no acceptable scoring systems for other tissues and organs.", "The average scores of lesions in lung and lymph nodes in pigs of the three PCV2-inoculated groups were statistically different from those in the control pigs of Group 1.The average scores of the liver lesions in pigs of the three PCV2-inoculated groups are not statistically different from those of control pigs.", "TABLE 3 Gross Lesions of Lung and Lymph Nodes in Control and PCV2-Inoculated Pigs 21 DPI 35 DPI Route of Lymph Lymph Group Inocula Inoculation Nodes Lung Nodes Lung 1 None 0/5a 0/5 0/5 0/5 2 PCV2 live virusb Intranasal 5/5 1/5(0-1)c 5/5 4/5(0-5) 3 PCV2 DNAd Intrahepatic 2/5 2/5(0-2) 5/5 2/5(0-13) 4 PCV2 DNAd Intralymphoid 4/5 5/5(0-1) 3/5 1/5(0-9) aFive pigs from each group were necropsied at 21 DPI, and the remaining 5 pigs were necropsied at 35 DPI.", "Number positive/number tested.", "bA biologically pure and homogeneous PCV2 virus stock generated by transfection of PK-15 cells with PCV2 molecular DNA clone.", "cNumber with lesions/number tested (range of the estimated percent of the lung affected by grossly visible pneumonia lesions, 0-100%) dCloned PCV2 genomic DNA in pSK plasmid.", "TABLE 4 Distribution of Histopathological Lesions in Control and PCV2-Inoculated Pigs Route of Group Inocula Inoculation DPIa Lung b Liverc LNd Spleen Thymus Ileum Brain Heart Kidney Tonsil 1 None 21 0/5(0.0) 4/5(0.8) 0/5(0.0) 0/5 0/5 0/5 0/5 0/5 0/5 0/5 35 0/5(0.0) 4/5(0.8) 0/5(0.0) 0/5 0/5 0/5 0/5 0/5 0/5 0/5 2 PCV2 virus Intranasal 21 5/5(1.6) 5/5(1.2) 3/5(1.2) 1/5 0/5 0/5 4/5 3/5 1/5 0/5 35 3/5(0.6) 4/5(1.0) 4/5(0.8) 3/5 0/5 3/5 4/5 0/5 1/5 3/5 3 PCV2 DNA Intrahepatic 21 5/5(1.0) 5/5(1.0) 5/5(1.0) 1/5 0/5 0/5 5/5 4/5 1/5 0/5 35 5/5(1.2) 5/5(1.0) 4/5(1.0) 2/5 0/5 3/5 3/5 4/5 5/5 3/5 4 PCV2 DNA Intralymphoid 21 5/5(1.2) 5/5(1.0) 5/5(0.8) 0/5 0/5 0/5 4/5 4/5 3/5 0/5 35 5/5(1.0) 5/5(1.2) 5/5(1.4) 0/5 0/5 1/5 3/5 3/5 3/5 2/5 aDays postinoculation (DPI): 5 animals from each group were necropsied at 21 DPI and the remaining 5 animals from each group were necropsied at 35 DPI b Number positive/number tested (Average histological lung score: 0 = normal, 1 = mild interstitial pneumonia, 2 = moderate, 3 = severe) cNumber positive/number tested (Average histological liver score: 0 = normal, 1 = mild hepatitis, 2 = moderate, 3 = severe) dNumber positive/number tested (Average histological lymphoid (LN) depletion score: 0 = normal, 1 = mild, 2 = moderate, 3 = severe) Example 8 Immunohistochemistry Immunohistochemistry (IHC) detection of PCV2-specific antigen was performed on all tissues collected during necropsies at DPIs 21 and 35.A rabbit polyclonal PCV2-specific antiserum was used for the IHC, and the general procedures have been previously described (S. D. Sorden et al., 1999, supra).", "For the detection and tissue distribution of PCV2 antigen, IHC staining of PCV2 antigen was done on brain, lungs, turbinate, heart, kidneys, tonsil, lymph nodes, spleen, thymus, ileum, liver, gall bladder and pancreas of all pigs necropsied at 21 and 35 DPI.", "All tissues from the control pigs were negative for PCV2 antigen.", "Tissue distribution of PCV2 antigen in the three PCV2-inoculated groups was similar (see Table 5, below).", "In the brain, the PCV2 antigen was found predominately in mononuclear cells, fibroblast-like cells, and endothelial cells in the meninges and choroid plexus and less often in endothelial cells and perivascular mononuclear cells in the cerebrum and cerebellum.", "In the lungs, PCV2 antigen was detected within alveolar and septal macrophages and in fibroblast-like cells in the lamina propria of airways (FIG.", "3D).", "In the heart, PCV2 antigen was detected in widely scattered macrophages and endothelial cells.", "In kidneys, PCV2 antigen was detected within tubular epithelial cells and mononuclear cells in the interstitium.", "In the lymphoid tissues (lymph nodes, spleen, tonsil, and Peyer's patches), PCV2 antigen was detected primarily within macrophages and dendritic-like cells and giant cells within follicles (FIG.", "4D).", "PCV2 antigen was also detected within macrophages in the lamina propria of the small intestine.", "In the liver, PCV2 antigen was detected within mononuclear cells and Kupffer cells.", "PCV2 antigen was not detected in turbinate, thymus, or gall bladder.", "TABLE 5 Detection and Distribution of PCV2-Specific Antigen by Immunohistochemistry in Control and PCV2-Inoculated Pigs Route of Group Inocula Inoculation DPIa Lung Liver LN Spleen Thymus Ileum Brain Heart Kidney Tonsil 1 None 21 0/5b 0/5 0/5 0/5 0/5 0/5 0/5 0/5 0/5 0/5 35 0/5 0/5 0/5 0/5 0/5 0/5 0/5 0/5 0/5 0/5 2 PCV2 virus Intranasal 21 4/5 5/5 5/5 3/5 0/5 3/5 3/5 1/5 1/5 2/5 35 1/5 2/5 3/5 2/5 0/5 0/5 2/5 0/5 0/5 0/5 3 PCV2 DNA Intrahepatic 21 5/5 5/5 5/5 5/5 0/5 0/5 5/5 1/5 0/5 2/5 35 4/5 4/5 3/5 4/5 0/5 3/5 4/5 2/5 2/5 3/5 4 PCV2 DNA Intralymphoid 21 4/5 4/5 5/5 4/5 0/5 3/5 3/5 0/5 0/5 3/5 35 3/5 4/5 5/5 4/5 0/5 2/5 3/5 1/5 0/5 4/5 aDays postinoculation (DPI): 5 animals from each group were necropsied at 21 DPI and the remaining 5 animals from each group were necropsied at 35 DPI bNumber positive/number tested Example 9 Construction of the Nonpathogenic PCV1 Infectious DNA Clone The procedure used to construct a PCV1 infectious DNA clone is essentially the same as that described herein for PCV2.A pair of PCR primers, KPNPCV1.0 set forth in SEQ ID NO:7 and KPNPCV1.L set forth in SEQ ID NO:8 (see Table 6, below), was designed based on the published sequence of PCV1.This pair of primers amplifies the complete genome of PCV1 with an overlapping region containing the unique KpnI restriction enzyme site.", "The DNA of the PCV1 virus was extracted from the contaminated ATCC PK-15 cell line that was obtained from the American Type Culture Collection (ATCC accession number CCL-33).", "The PCV1 DNA was extracted from the ATCC PK-15 cells persistently infected with PCV1, using the QIAmp DNA minikit (Qiagen, Inc., Valencia, Calif.).", "The extracted DNA was amplified by PCR with AmpliTaq Gold Polymerase (Perkin-Elmer, Norwalk, Conn.).", "The PCR cycles consisted of an initial step of 95° C. for 10 min., followed by 35 cycles of denaturation at 94° C. for 1 min., annealing at 48° C. for 1 min., extension at 72° C. for 2 min., and a final extension at 72° C. for 7 min.", "The PCR product of expected size was separated by gel electrophoresis and purified by the glassmilk procedure using a Geneclean Kit (Bio 101, Inc., La Jolla, Calif.).", "The purified PCR product containing the complete PCV1 genome was first ligated into the advanTAge plasmid vector (Clontech, Palo Alto, Calif.).", "Escherichia coli DH5a competent cells were used for transformation.", "The recombinant plasmids were verified by restriction enzyme digestion.", "The full length PCV1 genomic DNA was excised from the advanTAge vector by digestion with KpnI restriction enzyme.", "The full-length PCV1 genomic DNA was ligated into pBluescript SK(+) (pSK) vector (Stratagene, La Jolla, Calif.) with T4 DNA ligase at 37° C. overnight.", "Recombinant plasmids containing the full-length PCV1 genome were isolated with a Qiagen plasmid mini kit (Qiagen, Valencia, Calif.) and were verified by restriction enzyme digestion and DNA sequencing.", "The full-length PCV1 genomic DNA was excised from the pSK vector by KpnI digestion, and dimmerized to make the PCV1 infectious DNA clone as described above in Example 2 for the PCV2 infectious clone.", "These tandem dimers were made because the dimmerized tandem DNA clones are advantageously found to be more efficient to transfect cells and produce infectious virions.", "To make the tandem dimer of the PCV1 DNA, the digested PCV1 genomic DNA was ligated with T4 DNA ligase at 37° C. for only 10 min., which favors the production of tandem dimers.", "The tandem dimers were subsequently cloned into pBluescript SK(+) (pSK) vector (Stratagene, La Jolla, Calif.).", "Recombinant plasmids containing tandem dimers of PCV1 genome (herein referred to as “PCV1 DNA clone”) were confirmed by PCR, restriction enzyme digestion, and DNA sequencing.", "The DNA concentration of the recombinant plasmids was determined spectrophotometrically.", "TABLE 6 Oligonucleotide Primers Employed in this Invention Primer Direction Primer Sequence Application Construction primers: KPNPCV1.U.", ">a 5′-TTTGGTACCCGAAGGCCGATT-′3 PCV1 DNA (corresponds to SEQ ID NO: 7) clone construction KPNPCV1.L.", "< 5′-ATTGGTACCTCCGTGGATTGTTCT-′3 PCV1 DNA (corresponds to SEQ ID NO: 8) clone construction Hpa I-2 < 5′-GAAGTTAACCCTAAATGAATAAAAATAAAAACCATTACG-′3 PCV1-2 DNA (corresponds to SEQ ID NO: 9) clone construction Nar I-3 > 5′-GGTGGCGCCTCCTTGGATACGTCATCCTATAAAAGTG-′3 PCV1-2 DNA (corresponds to SEQ ID NO: 10) clone construction Psi I-5 > 5′-AGGTTATAAGTGGGGGGTCTTTAAGATTAA-′3 PCV1-2 DNA (corresponds to SEQ ID NO: 11) clone construction Acl I-6 < 5′-GGAAACGTTACCGCAGAAGAAGACACC-′3 PCV1-2 DNA (corresponds to SEQ ID NO: 12) clone construction Bgl-II-ORF2 > 5′-ACTATAGATCTTTATTCATTTAGAGGGTCTTTCAG-′3 PCV2-1 DNA (corresponds to SEQ ID NO: 13) clone construction SpH-I-ORF2 < 5′-TACGGGCATGCATGACGTGGCCAAGGAGG-′3 PCV2-1 DNA (corresponds to SEQ ID NO: 14) clone construction Bgl-II-PCV2 < 5′-AGACGAGATCTATGAATAATAAAAACCATTACGAAG-′3 PCV2-1 DNA (corresponds to SEQ ID NO: 15) clone construction SpH-I-PCV2 > 5′-CGTAAGCATGCAGCTGAAAACGAAAGAAGTG-′3 PCV2-1 DNA (corresponds to SEQ ID NO: 16) clone construction Detection primers: MCV1 > 5′-GCTGAACTTTTGAAAGTGAGCGGG-′3 PCV1 and PCV2 (corresponds to SEQ ID NO 17) detection MCV2 < 5′-TCACACAGTCTCAGTAGATCATCCCA-′3 PCV1 and PCV2 (corresponds to SEQ ID NO: 18) detection Orf.PCV1 < 5′-CCAACTTTGTAACCCCCTCCA-′3 PCV1 and (corresponds to SEQ ID NO: 19) PCV2-1 detection Gen.PCV1 > 5′-GTGGACCCACCCTGTGCC-′3 PCV1 and (corresponds to SEQ ID NO: 20) PCV1-2 detection Nested.OrfPCV1 < 5′-CCAGCTGTGGCTCCATTTAA-′3 PCV1 and (corresponds to SEQ ID NO: 21) PCV2-1 detection Nested.Gen.PCV1 > 5′-TTCCCATATAAAATAAATTACTGAGTCTT-′3 PCV1 and (corresponds to SEQ ID NO: 22) PCV1-2 detection Orf.PCV2 < 5′-CAGTCAGAACGCCCTCCTG-′3 PCV2 and (corresponds to SEQ ID NO: 23) PCV1-2 detection Gen.PCV2 > 5′-CCTAGAAACAAGTGGTGGGATG-′3 PCV2 and (corresponds to SEQ ID NO: 24) PCV2-1 detection Nested.OrfPCV2 < 5′-TTGTAACAAAGGCCACAGC-′3 PCV2 and (corresponds to SEQ ID NO: 25) PCV1-2 detection Nested.Gen.PCV2 > 5′-GTGTGATCGATATCCATTGACTG-′3 PCV2 and (corresponds to SEQ ID NO: 26) PCV2-1 detection aPrimer direction.", "Example 10 Evaluation of Infectivity of the PCV1 DNA Clone when Transfected into PK-15 Cells Free of Virus Contamination The infectivity of the PCV1 molecular DNA clone was determined by in vitro transfection of the PK-15 cells.", "IFA with PCV1 specific monoclonal antibody (a gift from Dr. Gordon Allan, Belfast, U.K.) confirmed that the PCV1 molecular DNA clone is infectious in PK-15 cells.", "PCV1-specific antigen was visualized by IFA in the nucleus, and to a lesser degree cytoplasm of the transfected cells.", "The cells mock-transfected with the empty pSK vector remained negative for PCV1 antigen.", "Example 11 Construction of a Chimeric PCV1-2 Viral DNA Clone A chimeric virus was constructed between the nonpathogenic PCV1 and the PMWS-associated PCV2 by using infectious DNA clones of PCV1 and PCV2.To construct a chimeric PCV1-2 DNA clone, the ORF2 capsid gene of the nonpathogenic PCV1 was removed from the PCV1 infectious DNA clone, and replaced with the immunogenic ORF2 capsid gene of the pathogenic PCV2 in the genome backbone of PCV1 (see FIGS.", "5 and 6).", "Two pairs of PCR primers were designed.", "The first primer pair for PCV2 ORF2, Psi I-5 set forth in SEQ ID NO:11 and Ad 1-6 set forth in SEQ ID NO:12, was designed with point mutations at the 5′ ends of the primers to create restriction enzyme sites AclI and PsiI to amplify the ORF2 gene of PCV2 and introduce flanking PsiI and AclI restriction enzyme sites by point mutation.", "The PCR reaction for the PCV2 ORF2 amplification consisted of an initial step at 95° C. for 9 min., followed by 38 cycles of denaturation at 95° C. for 1 min., annealing at 48° C. for 1 min., extension at 72° C. for 1 min., and a final extension at 72° C. for 7 min.", "A second pair of PCR primers, Hpa 1-2 set forth in SEQ ID NO:9 and Nar 1-3 set forth in SEQ ID NO:10, was designed for the amplification of the pSK+ vector and its PCV1 genome insert.", "Point mutations were introduced at the 5′ ends of the PCR primers to create flanking restriction enzyme sites NarI and HpaI.", "This primer pair amplified the pSK+ vector and its insert PCV1 genomic DNA lacking the ORF2 capsid gene, that is, the PCV1 genome minus the PCV1 ORF2 (pSK-PCV1 ΔORF2) by using the PCV1 infectious DNA clone as the PCR template.", "The PCR reaction consisted of an initial step at 95° C. for 9 min., followed by 38 cycles of denaturation at 95° C. for 1 min., annealing at 50° C. for 1 min., extension at 72° C. for 3.5 min., and a final extension at 72° C. for 7 min.", "The PCV2 ORF2 PCR product was digested with the AclI and PsiI to remove the introduced point mutations.", "The pSK-PCV1 ΔORF2 product (the pSK vector-PCV1 genome PCR product lacking ORF2 gene of PCV1) was digested with the NarI and HpaI to remove the PCR introduced point mutations.", "The latter digestion produced a sticky end and a blunt end complementary to the PCV2 ORF2 PCR product digested by the AclI and PsiI restriction enzymes.", "The digested PCV2 ORF2 product and the ORF2-deleted pSK-PCV1 product were ligated with T4 DNA ligase to form the chimeric PCV1-2 genomic DNA clone, in which the ORF2 gene of PCV1 is replaced with the ORF2 gene of PCV2.Once the two PCR products were digested and religated, all the PCR introduced point mutations used to facilitate cloning were removed in the resulting chimeric clone.", "Escherichia coli DH5a competent cells were transformed.", "The recombinant plasmids containing the chimeric DNA clone were isolated and confirmed by PCR, restriction enzyme digestion and partial DNA sequencing.", "The full-length chimeric PCV1-2 genome was excised from the pSK+ vector (the recombinant plasmid) with KpnI digestion.", "The chimeric DNA genome was then dimmerized by a short 10-minute ligation reaction with T4 DNA ligase that favors the formation of linear dimers to produce the PCV1-2 chimeric infectious DNA clone (FIG.", "6).", "The recombinant plasmids containing two copies of the chimeric viral genome were confirmed by PCR, restriction enzyme digestion and DNA sequencing.", "Example 12 Evaluation of In Vitro Infectivity of PCV1-2 Chimeric DNA Clone The viability of the chimeric PCV DNA clone (nonpathogenic PCV1 with the immunogenic capsid gene of PCV2) was tested in PK-15 cells.", "When PK-15 cells were transfected with the chimeric viral DNA clone, viral antigen specific for PCV2 ORF2 capsid was detected by IFA at about 2 days post-transfection.", "The PCV1 capsid antigen was not detected in transfected cells.", "This experiment indicated that the chimeric DNA clone is infectious in vitro, is replicating in PK-15 cells and producing the immunogenic capsid protein of PCV2.Example 13 Construction of a Reciprocal Chimeric PCV2-1 DNA Clone To construct a reciprocal PCV2-1 chimeric DNA clone, the ORF2 capsid gene of PCV2 is replaced by that of the non-pathogenic PCV1 in the genome backbone of the pathogenic PCV2 (FIG.", "6).", "Two PCR primer pairs were designed: the pair, Bgl-II-ORF2 set forth in SEQ ID NO:13 and SpH-I-ORF2 set forth in SEQ ID NO:14, amplifies the PCV1 ORF2 gene and introduces flanking BglII and SpHI restriction enzyme sites by point mutation.", "The second PCR primer pair, Bgl-II-PCV2 set forth in SEQ ID NO:15 and SpH-I-PCV2 set forth in SEQ ID NO:16, amplified the pSK vector and the PCV2 genome minus the ORF2 gene (pSK-PCV2 ΔORF2) by using the PCV2 infectious DNA clone as the PCR template, and introduced flanking restriction enzymes sites BglII and Spill by point mutation.", "The pSK-PCV2 ΔORF2 product and the PCV1 ORF2 PCR product were digested by BglII and SpHI restriction enzymes to produce complementary sticky and blunt ends ligated together.", "After transformation into E. Coli cells, the authentic recombinant plasmids were isolated and confirmed by enzyme digestion and partial DNA sequencing.", "The full-length reciprocal chimeric PCV2-1 genome was excised from the recombinant plasmid by SacII digestion, and dimmerized as described herein to produce the reciprocal chimeric PCV2-1 infectious clone.", "Example 14 In Vitro Transfection of PK-15 Cells with PCV1, PCV2, PCV1-2 and PCV2-1 DNA Clones The infectivity of PCV2 clone in vitro and in vivo has been demonstrated in the above Examples 3-5.To test the infectivity of the PCV1 and two chimeric clones in vitro, PK-15 cells free of PCV1 contamination prepared per the method of Example 1 were grown in 8-well LabTek chambers slides (Nalge Nunc Int., Denmark).", "When the PK-15 cells reached about 80% confluency, cells were transfected with PCV1, PCV2, PCV1-2 and PCV2-1 DNA clones respectively, using the Lipofectamine Plus Reagent according to the protocols supplied by the manufacturer (Life Technologies, Inc.).", "Mock-transfected cells with empty pSK vector were included as controls.", "Three days after transfection, the cells were fixed with a solution containing 80% acetone and 20% methanol at 4° C. for 20 min.", "Evidence of infectivity and virus replication in cells transfected with the PCV1 and PCV2-1 DNA clones were confirmed by indirect immunofluorescence assay (IFA) using monoclonal antibody against PCV1 ORF2 capsid gene, kindly provided by Dr. G. M. Allan (G. M. Allan et al., “Production, preliminary characterization and applications of monoclonal antibodies to porcine circovirus,” Vet.", "Immunol.", "Immunopathol.", "43:357-371 (1994)).", "The fixed cells were washed with phosphate buffered saline (PBS) and incubated with 1:20 diluted PCV1 monoclonal antibody at 37° C. for 1 hour.", "The cells were then washed three times with PBS buffer and incubated with fluorescein isothiocyanate (FITC) labeled goat anti-mouse immunoglobulin G (Kirkegaard & Perry Laboratories, Inc., Gaithersburg, Md.)", "at 37° C. for 45 min.", "After washing three times with PBS buffer, the slides were mounted with fluoromount-G, coverslipped, and examined under a fluorescence microscope.", "The infectivity of cells transfected with the PCV2 and the chimeric PCV1-2 DNA clones were confirmed by IFA using antibody specific for PCV2, as previously described in Example 4.The infectivity of the PCV1, the chimeric PCV1-2 DNA and the reciprocal chimeric PCV2-1 DNA clones were substantiated by the in vitro transfection of PK-15 cells.", "Two identical copies of the complete PCV1 genome were ligated in tandem into the pSK vector to produce the PCV1 DNA clone (FIG.", "6).", "The chimeric PCV1-2 DNA clone had the ORF2 capsid gene of PCV1 replaced by that of the pathogenic PCV2 in the backbone of the nonpathogenic PCV1 genome.", "The reciprocal chimeric PCV2-1 DNA clone had the ORF2 capsid gene of PCV2 replaced by that of the nonpathogenic PCV1 in the backbone of the pathogenic PCV2 genome.", "If infectious in vitro, the chimeric PCV1-2 DNA clone will produce the ORF2 capsid antigen of PCV2 and the reciprocal chimeric PCV2-1 DNA clone will express PCV1 ORF2 capsid antigen in transfected PK-15 cells.", "The results showed that the PCV1, the chimeric PCV1-2 and the reciprocal chimeric PCV2-1 DNA clones were all surprisingly shown to be infectious when transfected into PK-15 cells and expressed respective viral capsid antigen proteins as demonstrated by IFA using antibodies specific for PCV1 or PCV2.IFA using monoclonal antibodies against PCV1 ORF2 and antibodies against PCV2 confirmed that the PCV1 DNA and the PCV1-2 DNA clones were infectious.", "IFA using PCV1 ORF2-specific monoclonal antibody showed that the PCV1-2 chimeric DNA clone was also infectious.", "About 10-20% of the transfected PK-15 cells were positive for PCV1 capsid antigen and PCV2 antigen, and expressed PCV1 ORF2 antigen, within the nucleus of transfected cells (FIG.", "7).", "Example 15 Experimental Inoculation of Pigs with PCV1, PCV2, Chimeric PCV1-2 and Reciprocal Chimeric PCV2-1 DNA Clones To evaluate the immunogenicity and pathogenicity of the chimeric DNA clones, forty specific-pathogen-free (SPF) pigs of 4-6 weeks of age were randomly assigned into five rooms of 8 animals each.", "Prior to inoculation, animals were tested for antibodies to PCV, PRRSV, PPV, and swine hepatitis E virus.", "In addition, pre-inoculation serum samples were tested by PCR for PCV1 and PCV2 nucleic acid to confirm that the pigs are not naturally infected by either of the viruses.", "The PCV1, PCV2, PCV1-2 and PCV2-1 DNA clones were all inoculated by direct injection of the cloned plasmid DNA into the superficial iliac lymph nodes of pigs.", "Pigs in Group 1 received phosphate buffered saline (PBS buffer) and served as the negative control.", "Group 2 pigs were each injected into the superficial iliac lymph nodes with 200 μg of infectious PCV1 DNA clone.", "Group 3 pigs were each injected with 200 μg of infectious PCV2 DNA clone.", "Group 4 pigs each received injections of 200 μg of infectious chimeric PCV1-2 DNA clone.", "Group 5 pigs each received 200 μg of the infectious reciprocal chimeric PCV2-1 DNA clone.", "All animals were monitored daily for clinical signs of disease.", "Serum samples were collected from each animal at −2, 7, 14, 21, 28, 35, 42 and 49 days post-inoculation (DPI).", "At 21 DPI, four randomly selected animals from each group were necropsied.", "The remaining four animals in each group were necropsied at 49 DPI.", "Various tissues and organs were collected during necropsy as previously described in Example 7, and processed for histological examination.", "The immunogenicity of the PCV1, the PCV2 and the chimeric infectious DNA clones was examined in the pigs.", "Serum samples collected from all control and inoculated animals at −2 (0), 7, 14, 21, 28, 35, 42 and 49 DPIs were assayed for PCV1, PCV2, PCV1-2 and PCV2-1 viremia by PCR detection of clone-specific DNA sequences, for anti-PCV1 antibody by IFA and for anti-PCV2 ORF2 antibody by ELISA.", "Prior to inoculation at −2 DPI, animals from all five groups tested negative by PCR for both PCV1 and PCV2 DNA.", "Negative control animals were negative for both PCV1 and PCV2 viremia throughout the study (see Table 7, below).", "Five pigs in the uninoculated control group had detectable PCV2 maternal antibody at −2 DPI and 2 pigs had detectable PCV1 maternal antibodies at 7 DPI (see Table 8, below).", "The maternal antibodies to both PCV1 and PCV2 in these piglets waned by 21 DPI.", "No seroconversion to either PCV1 or PCV2 was detected in any of the 8 uninoculated control pigs throughout the study.", "In the PCV1 inoculated group, viremia was first detected in an inoculated pig at 7 DPI (Table 7, below), and was last detected at 35 DPI.", "Five out of 8 animals inoculated with PCV1 infectious DNA clone were positive for PCV1 viremia.", "Average length of continuous PCV1 viremia was 0.625 weeks.", "By 21 DPI, all animals in the PCV1 inoculated group had seroconverted to PCV1 and remained positive to PCV1 antibodies until the end of the study at 49 DPI.", "The PCV2 DNA clone is shown herein to be infectious in pigs.", "In the PCV2 DNA clone inoculated group, PCV2 viremia was first detected at 7 DPI (Table 7, below).", "By 21 DPI, all PCV2 inoculated Group 3 animals were positive for PCV2 viremia.", "The average length of PCV2 viremia was 2.12 weeks.", "Two pigs in the PCV2 inoculated group had detectable levels of maternal PCV2 antibodies at 7 DPI (Table 8, below), and the maternal antibodies in these piglets waned by 14 DPI.", "Seroconversion to PCV2, assayed by a PCV2-specific ELISA, was first detected at 35 DPI.", "By 42 DPI, all pigs inoculated with PCV2 infectious DNA clone had seroconverted to PCV2.In Group 4 pigs inoculated with PCV1-2 chimeric infectious DNA clone, viremia specific for the chimeric virus was first detected at 14 DPI (Table 7, below).", "Four out of 7 inoculated animals became viremic to PCV1-2 between 14 DPI and 42 DPI.", "The average length of chimeric PCV1-2 viremia was 1 week.", "One pig had detectable levels of maternal PCV2 antibodies at 7 and 14 DPI, but the maternal antibody waned by 21 DPI (Table 8, below).", "Seroconversion to PCV2 ORF2-specific antibody first occurred at 28 DPI.", "By 49 DPI, all pigs inoculated with chimeric PCV1-2 DNA clone had seroconverted to PCV2 ORF2-specific antibody.", "In pigs inoculated with the reciprocal chimeric PCV2-1 clone, viral DNA specific for PCV2-1 chimeric virus was not detected in serum samples (Table 7, below).", "However, by 21 DPI all animals in Group 5 seroconverted to PCV1 antibody.", "PCR products amplified from selected pigs in each group were sequenced and confirmed to be the authentic respective infectious clones used in the inoculation in each group.", "TABLE 7 Detection of Viremia by Nested PCR in Sera of Inoculated and Control Pigs DPI Group Inoculum −2 7 14 21 28 35 42 49 Total 1 PBSa 0/8b 0/8 0/8 0/8 0/4 0/4 0/4 0/4 0/8 2 PCV1 DNAc 0/8 1/8 1/8 2/8 0/4 2/4 0/4 0/4 5/8 3 PCV2 DNAc 0/8 3/8 6/8 7/8 1/4 2/4 2/4 0/4 8/8 4 PCV1-2 DNAc 0/7 0/7 1/7 2/7 2/4 2/4 2/4 0/4 4/7 5 PCV2-1 DNAc 0/8 0/8 0/8 0/8 0/4 0/4 0/4 0/4 0/8 aPhosphate buffered saline (PBS) used as negative control bEight pigs in each group; number positive/number tested cCloned genomic PCV or chimeric PCV DNA in pSK plasmid TABLE 8 Seroconversion to Antibodies Against PCV2 in Pigs Inoculated with PCV2 or Chimeric PCV1-2 DNA Clones and Seroconversion to Antibodies Against PCV1 in Pigs Inoculated with PCV1 or PCV2-1 DNA Clones DPIc Group Inoculuma Antibody Tested Forb −2 7 14 21 28 35 42 49 1 PBS PCV1 NA 2/8 2/8 1/8 0/4 0/4 0/4 0/4 PCV2 5/8 5/8 2/8 0/8 0/4 0/4 0/4 0/4 2 PCV1 DNA PCV1 ORF2 NA 3/8 2/8 8/8 4/4 4/4 4/4 4/4 3 PCV2 DNA PCV2 complete virus 3/8 2/8 0/8 0/8 0/4 3/4 4/4 4/4 4 PCV1-2 DNA PCV2 complete virus 2/8 1/8 1/8 0/8 1/4 1/4 3/4 4/4 5 PCV2-1 DNA PCV1 ORF2 NA 3/8 3/8 8/8 3/4 3/4 4/4 4/4 aPhosphate buffered saline (PBS) used as negative control.", "The inocula were cloned genomic PCV and PCV chimeric DNA in pSK plasmid bPCV1 antibody to ORF2 was measured with an indirect immunofluorescence assay specific for PCV1 antigen.", "PCV2 antibody was measured with an enzyme-linked immunosorbent assay.", "cDays post inoculation.", "number positive/number tested.", "Example 16 Clinical Evaluation Pigs were weighed on 0 DPI and at the time of necropsies.", "Rectal temperatures and clinical respiratory scores, ranging from 0 to 6 (0=normal; 6=severe) (P. G. Halbur et al., “Comparison of the pathogenicity of two U.S. porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus,” Vet.", "Pathol.", "32:648-660 (1995)), were recorded every other day from 0 to 49 DPI.", "Clinical observations, including evidence of central nervous system disease, liver disease (icterus), muscoloskeletal disease and changes in body condition, were also recorded daily.", "A team of two people performed all clinical evaluations.", "None of the control or inoculated pigs showed obvious signs of the full-spectrum clinical PMWS.", "There were no differences in weight gain or mean rectal temperatures between any of the groups.", "One of the pigs from PCV1-2 inoculated Group 3 died one day after inoculation.", "After necropsy and clinical analysis, no pathogenic agent was detected and death was not associated with the inoculation procedure or the chimeric PCV1-2 virus.", "Example 17 Gross Pathology and Histopathology Four pigs from each group were necropsied at 21 and 49 DPI, respectively.", "The necropsy team was blinded to infection status of the pigs at necropsy.", "Complete necropsies were performed on all pigs.", "An estimated percentage of the lung with grossly visible pneumonia was recorded for each pig based on a previously described scoring system (P. G. Halbur et al., 1995, supra).", "Other lesions such as enlargement of lymph nodes were noted separately.", "Sections for histopathologic examination were taken from nasal turbinate, lungs (seven sections) (id.", "), heart, brain, lymph nodes (tracheobronchial, iliac, mesenteric, subinguinal), tonsil, thymus, liver, gall bladder, spleen, joints, small intestine, colon, pancreas, and kidney.", "The tissues were examined in a blinded fashion and given a subjective score for severity of lung, lymph node, and liver lesions as described in Example 7.Lung scores ranged from 0 (normal) to 3 (severe lymphohistiocytic interstitial pneumonia).", "Liver scores ranged from 0 (normal) to 3 (severe lymphohistiocytic hepatitis).", "Lymph node scores were for an estimated amount of lymphoid depletion of follicles ranging from 0 (normal or no lymphoid depletion) to 3 (severe lymphoid depletion and histiocytic replacement of follicles).", "To determine the pathogenicity of PCV1, PCV2, chimeric PCV1-2 and reciprocal chimeric PCV2-1 infectious DNA clones in pigs, gross lesions were examined first.", "The results are shown in Table 9 below.", "Lymph nodes of animals from the uninoculated control Group 1 were normal at both 21 and 49 DPIs.", "Pigs in the four inoculated groups had variable degrees of gross lesions limited to the lymph nodes.", "In PCV1 inoculated Group 2 pigs, lymph nodes were grossly normal at 21 DPI, however, mild to moderate swelling and discoloration of lymph nodes was detected at 49 DPI.", "All PCV2 inoculated Group 3 pigs had enlarged lymph nodes two to five times the normal size, that were firm and tan colored at both 21 and 49 DPIs.", "Lymph nodes from chimeric PCV1-2 inoculated animals were mild to moderately swollen and discolored at both 21 and 49 DPIs in 5 out of 7 pigs.", "In Group 5 pigs, inoculated with the PCV2-1 clone, 1 out of 8 animals had mild swelling and discoloration of the lymph nodes at 21 DPI.", "The average scores of gross lesions of the lymph nodes in pigs inoculated with chimeric PCV1-2 clone were not statistically different from those in Groups 1, 2, and 5, but were statistically different from those of the pathogenic PCV2 inoculated Group 3 pigs at both 21 and 49 DPIs.", "Average lymphoid gross lesion scores on 49 DPI from the PCV1, PCV2, and PCV1-2 inoculated animals were not statistically different from each other, but were all statistically different from the average gross lesion scores of Groups 1 and 5.Next, microscopic lesions were examined.", "The results are shown in Table 10 below.", "No microscopic lesions were detected in either uninoculated control Group 1 pigs or PCV1 inoculated Group 2 pigs at any DPI.", "Microscopic lung lesions characterized as mild peribronchiolar lymphoplasmacytic and histiocytic bronchointerstitial pneumonia, were observed in 1 out 8 of the PCV2 inoculated pigs.", "In PCV1-2 and PCV2-1 inoculated animals, no microscopic lesions were observed in the lungs.", "No lesions were observed in the thymuses of any inoculated pigs.", "Mild multifocal lymphoplasmacytic myocarditis was observed in 2 of 8 pigs in the PCV2 inoculated group.", "Heart tissues from PCV1-2 and PCV2-1 inoculated animals were free of microscopic lesions.", "Mild multifocal lymphoplasmacytic interstitial nephritis was observed in 4 out of 8 pigs in PCV2 inoculated group, in 2 out of 7 PCV1-2 inoculated pigs and in 1 out of 8 PCV2-1 inoculated pigs.", "Mild-to-moderate lymphoid depletion and histiocytic replacement of follicles were observed in the tonsil in 5 out of 8 pigs, in the spleen in 3 out of 8 pigs, and in the lymph nodes in 8 out of 8 pigs in the PCV2-inoculated group.", "In the chimeric PCV1-2 inoculated animals, mild lymphoid depletion and histiocytic replacement of follicles were observed in the lymph nodes of 2 out of 7 pigs but were not detected in either the spleen or tonsils.", "No lymphoid depletion and histiocytic replacement of follicles were observed in the lymph nodes, spleen or tonsils of the reciprocal chimeric PCV2-1 inoculated animals.", "Mild-to-moderate lymphoplasmacytic hepatitis was observed in 7 out of the 8 PCV2-inoculated pigs.", "Mild lymphoplasmacytic hepatitis was observed in 2 out of the 7 chimeric PCV1-2 inoculated pigs.", "No lymphoplasmacytic hepatitis was observed in reciprocal chimeric PCV2-1 inoculated pigs.", "Lesions in other tissues were unremarkable.", "Microscopic lesions in the lung, liver, and lymph nodes were scored according to a published scoring system (P. G. Halbur et al., 1995, supra).", "The results are shown in Table 10 below.", "Average scores of lesions in lymph nodes in pigs from the chimeric PCV1-2 inoculated Group 4 were similar to those from Groups 1, 2 and 5 but were statistically different from those of the pathogenic PCV2 inoculated Group 3 pigs, at both 21 and 49 DPIs.", "Average microscopic liver lesion scores from the chimeric PCV1-2 inoculated group at 21 DPI were statistically different from those of PCV2 inoculated Group 3 animals but were similar to those of Groups 1, 2 and 5 pigs at 21 DPI.", "At 49 DPI, the average microscopic liver scores from Group 4 chimeric PCV1-2 inoculated pigs were not statistically different from those of Groups 1, 2, 3 and 5 pigs.", "There were no acceptable scoring systems for other tissues or organs.", "TABLE 9 Gross Lesions of Lymph Nodes in Control and Inoculated Pigs DPIb Group Inoculuma 21 49 1 PBS 0/4(0.0) 0/4(0.0) 2 PCV1 DNA 0/4(0.0) 4/4(1.5) 3 PCV2 DNA 4/4(2.5) 4/4(2.25) 4 PCV1-2 DNA 2/3(0.66) 3/4(1.25) 5 PCV2-1 DNA 1/4(0.25) 0/4(0.0) aPhosphate buffered saline (PBS) used as negative control.", "The inocula were cloned genomic PCV or chimeric PCV DNA in pSK plasmid.", "bFour pigs from each group were necropsied at 21 DPI and the remaining pigs were necropsied at 49 DPI; number positive/number tested.", "Number with lesions/number tested (range of estimated severety lymph node enlargement) TABLE 10 Distribution of Histopathological Lesions in Different Tissues/Organs from Control and Inoculated Pigs Group Inoculuma DPIb Lungc Liverd Lymph Nodese Spleen Thymus Ileum Brain Heart Kidney Tonsil 1 PBS 21 0/4(0.0) 0/4(0.0) 0/4(0.0) 0/4 0/4 0/4 0/4 0/4 0/4 0/4 49 0/4(0.0) 0/4(0.0) 0/4(0.0) 0/4 0/4 0/4 0/4 0/4 0/4 0/4 2 PCV1 DNA 21 0/4(0.0) 0/4(0.0) 0/4(0.0) 0/4 0/4 0/4 0/4 0/4 0/4 0/4 49 0/4(0.0) 0/4(0.0) 0/4(0.0) 0/4 0/4 0/4 0/4 0/4 0/4 0/4 3 PCV2 DNA 21 0/4(0.0) 4/4(1.5) 4/4(1.75) 3/4 0/4 0/4 1/4 1/4 2/4 3/4 49 1/4(0.25) 3/4(0.75) 4/4(1.0) 0/4 0/4 0/4 0/4 1/4 2/4 2/4 4 PCV1-2 DNA 21 0/3(0.0) 1/3(0.33) 1/3(0.33) 0/4 0/4 0/4 0/4 0/4 0/4 0/4 49 0/4(0.0) 1/4(0.25) 1/4(0.25) 0/4 0/4 0/4 0/4 0/4 2/4 0/4 5 PCV2-1 DNA 21 0/4(0.0) 0/4(0.0) 0/4 (0.0) 0/4 0/4 0/4 0/4 0/4 0/4 0/4 49 0/4(0.0) 0/4(0.0) 1/4(0.25) 0/4 0/4 0/4 0/4 0/4 0/4 0/4 aPhosphate buffered saline (PBS) used as negative control.", "The inocula were cloned genomic PCV or chimeric PCV DNA in pSK plasmid.", "bFour pigs from each group were necropsied at 21 DPI and the remaining pigs were necropsied at 49 DPI.", "cNumber positive/number tested (average histological lung score: 0, normal; 1, mild interstitial pneumonia; 2, moderate; 3, severe).", "dNumber positive/number tested (Average histiological liver sore: 0, normal; 1, mild hepatitis; 2, moderate; 3, severe.)", "eNumber positive/number tested (Average histiological lymphoid (lymph nodes) depletion score: 0, normal; 1, mild; 2, moderate; 3, severe.)", "Example 18 Serology Blood was collected from all pigs at −2, 7, 14, 21, 28, 35, 42 and 49 DPIs.", "Serum antibodies to PRRSV were assayed using Herd Check PRRSV ELISA (IDEXX Laboratories, Westbrook, Mass.).", "Serum antibodies to PPV were detected by a hemagglutination inhibition (HI) assay (H. S. Joo et al., “A standardized haemagglutination inhibition test for porcine parvovirus antibody,” Aust.", "Vet.", "J.", "52:422-424 (1976)).", "Serum antibodies to PCV2 were detected by a modified indirect ELISA based on the recombinant ORF2 capsid protein of PCV2 as described hereinabove (see also P. Nawagitgul et al., “Modified indirect porcine circovirus (PCV) type 2-based and recombinant capsid protein (ORF2)-based ELISA for the detection of antibodies to PCV,” Immunol.", "Clin.", "Diagn.", "Lab Immunol.", "1:33-40 (2002)).", "Serum antibodies to PCV1 were detected by an indirect immunofluorescence assay (IFA).", "PK-15 cells infected with PCV1 were grown on eight-well LabTek chamber slides.", "When the infected PK-15 cells reach about 95-100% confluency, the infected cells were fixed with a solution containing 80% acetone and 20% methanol at 4° C. for 20 min.", "The fixed cells were washed once with PBS buffer.", "One hundred microliters of 1:10 diluted pig serum sample in PBS was added to the chambers, and incubated for 1 hour at 37° C. The cells were then washed three times with PBS and incubated for 45 min.", "at 37° C. with FITC-labeled goat anti-swine secondary antibody.", "The slides were subsequently washed three times with PBS, mounted with fluoromount-G, coverslipped and examined under a fluorescent microscope.", "For the positive control, PCV1 infected cells were incubated with a diluted PCV1 specific monoclonal antibody (gift of Dr. G. M. Allan), followed by an incubation with FITC-labeled goat anti-mouse IgG (Kirkegaard & Perry Laboratories, Inc., Gaithersburg, Md.).", "For the negative control, PCV1 infected cells were incubated with 1:10 diluted swine serum free of PCV1 and PCV2 antibody, followed by an incubation with FITC-labeled goat anti-swine IgG (Kirkegaard & Perry Laboratories, Inc., Gaithersburg, Md.).", "Example 19 PCR Detection To detect PCV1, PCV2, chimeric PCV1-2 and reciprocal chimeric PCV2-1 viremia in sera from inoculated pigs, serum samples collected at different DPIs were tested by PCR.", "Viral DNA was extracted from 100 μl of each serum sample using DNAzol reagent according to the manufacturer's protocol (Molecular Research Center, Cincinnati, Ohio).", "The extracted DNA was resuspended in DNase, RNase and proteinase-free water.", "To amplify clone-specific genomic sequences of PCV1, PCV2, chimeric PCV1-2 and chimeric reciprocal PCV2-1, two sets of nested PCR primer pairs were designed (Table 6, above).", "The first set of nested primers was designed based on published PCV1 sequences.", "Primers Gen.PCV1 set forth in SEQ ID NO:20 and Orf.PCV1 set forth in SEQ ID NO:19 amplified a 400 bp fragment in the presence of the PCV1 genome.", "The nested primers, nested.Gen.PCV1 set forth in SEQ ID NO:22 and nested.Orf.PCV1 set forth in SEQ ID NO:21, amplified a 220 bp fragment.", "To detect PCV2 viremia, PCV2 primer pair Gen.PCV2 set forth in SEQ ID NO:24 and Orf.PCV2 set forth in SEQ ID NO:23 amplified a 900 bp fragment in the presence of PCV2 in the first round of PCR.", "Primers nested.Gen.PCV2 set forth in SEQ ID NO:26 and nested.Orf.PCV2 set forth in SEQ ID NO:25 amplified a 600 bp fragment in the nested PCR.", "To detect chimeric PCV1-2 viremia, the first round of PCR reaction employed the PCV1-specific primer Gen.PCV1 set forth in SEQ ID NO:20 and the PCV2 ORF2-specific primer Orf.PCV2 set forth in SEQ ID NO:23 to amplify a chimeric fragment of 580 bp.", "For the nested PCR, PCV1-specific primer nested.Gen.PCV1 set forth in SEQ ID NO:22 and the PCV2 ORF2-specific primer nested.Orf.PCV2 set forth in SEQ ID NO:25 were used to amplify a chimeric fragment of 370 bp.", "To detect reciprocal chimeric PCV2-1 viremia, the first round of PCR employed the PCV2-specific primer Gen.PCV2 set forth in SEQ ID NO:24 and the PCV1 ORF2-specific primer Orf.PCV1 set forth in SEQ ID NO:19 to amplify a chimeric fragment of 700 bp.", "For the nested PCR, the PCV2-specific primer nested.Gen.PCV2 set forth in SEQ ID NO:26 and the PCV1 ORF2-specific primer nested.Orf.PCV1 set forth in SEQ ID NO:21 were used to amplify a 460 bp chimeric fragment.", "All PCR parameters were essentially the same, consisting of 38 cycles of denaturation at 94° C. for 1 min., annealing at 45° C. for 1 min., and extension at 72° C. for 1.5 min.", "The serum samples from negative control pigs were tested by a PCR-RFLP diagnostic assay, which can detect and differentiate both PCV1 and PCV2 as described previously (M. Fenaux et al., “Genetic characterization of type 2 porcine circovirus (PCV-2) from pigs with postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential PCR-restriction fragment length polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2,” J. Clin.", "Microbiol.", "38: 2494-503 (2000)).", "PCR products from selected animals in each group were sequenced to verify the origin of the virus infecting pigs.", "Example 20 Immunohistochemistry (IHC) IHC detection of PCV2-specific antigen was performed on lymph node tissues collected from all pigs necropsied at 21 and 49 DPIs.", "A rabbit polyclonal antiserum against PCV2 was used for the IHC, according to the general procedures described previously (S. D. Sorden et al., “Development of a polyclonal-antibody-based immunohistochemical method for the detection of type 2 porcine circovirus in formalin-fixed, paraffin-embedded tissue,” J. Vet.", "Diagn.", "Invest.", "11:528-530 (1999)).", "Based on the IHC staining of PCV2-specific antigen, lymphoid tissues from the uninoculated control, PCV1 and PCV2-1 inoculated pigs were negative for PCV2 antigen.", "PCV2 antigen was detected in lymphoid tissues of 7 out of 8 animals in the PCV2 inoculated group.", "PCV2 antigen was also detected in lymphoid tissue of 1 out of 7 pigs from the chimeric PCV1-2 inoculated group.", "Examples 21-24 The following general materials and methods are employed in Examples 21-24: (1) Virus and Cell.", "The PCV1 virus used in this invention was originally isolated from a PK-15 cell line (ATCC CCL-33) (M. Fenaux et al., 2002, supra).", "The PCV2 virus used herein was originally isolated from a spleen tissue sample of a pig with naturally occurring PMWS (isolate 40895) (M. Fenaux et al., 2002, supra; M. Fenaux et al., 2000, supra,).", "The PK-15 cell line used herein was free of PCV1 contamination (M. Fenaux et al., 2002, supra).", "(2) Serial Passages of PCV2 In Vitro.", "A homogenous PCV2 virus stock, designated passage 1 (VP1), was generated by transfection of PK-15 cells with the PCV2 infectious DNA clone as previously described (M. Fenaux et al., 2002, supra).", "The VP1 PCV2 virus stock was then serially passaged for 120 times in PK-15 cells.", "The infected cells, when reaching confluency, were subcultured at an approximate 1 to 3 ratio in minimum essential medium (MEM) with Earle's salts and L-glutamine supplemented with 2% fetal calf serum (FCS) and 1× antibiotic (Invitrogen, Inc., CA).", "For every 10 to 15 passages, the infected cells were harvested by frozen and thawed three times, and used to inoculate a new PK-15 culture.", "The newly infected culture was then passed 10 to 15 times by subculturing before repeating the freeze-thaw procedure.", "This procedure was repeated until it reached passage 120 (VP120).", "The virus harvested at each passage was stored at −80 for further analyses.", "(3) Biological Characterization of PCV1, PCV2 VP1, and PCV2 VP120 Viruses in PK-15 Cells.", "A one-step growth curve was performed to determine the comparative growth ability of PCV1, PCV2 VP1, and PCV2 VP120 in vitro.", "PK-15 cells were grown on six 12-well plates.", "The plates were infected, in duplicate, with PCV1, PCV2 VP1 or PCV2 VP120 at a multiplicity of infection (M.O.I.)", "of 0.1, respectively.", "After 1 hour absorption, the inoculum was removed and the cell monolayer was washed five times with phosphate buffered saline (PBS).", "Maintenance MEM media (2% bovine calf serum and 1× antibiotics) was subsequently added to each well, and the infected cell cultures were continuously incubated at 37° C. with 5% CO2.Every 12 hours, the media and infected cells from duplicate wells of each inoculated group were harvested and stored at −80° C. until virus titration.", "The infectious titers of PCV1 and PCV2 viruses collected at different time points were determined by immunofluorescent assays (IFA) specific for PCV1 or PCV2 as previously described (M. Fenaux et al., 2002, supra; M. Fenaux et al., 2003, supra).", "(4) Genetic Characterization of PCV2 Viruses at Different Passages.", "PCV2 viruses harvested from passages 1, 30, 60, 90, and 120 were genetically characterized by determining the complete genomic sequences of the viruses from each passage.", "Viral DNA was extracted from 100 μl of the cell culture materials collected at passages 1, 30, 60, 90, and 120 by using DNAzol reagent according to the manufacturer's protocol (Molecular Research Center, Cincinnati, Ohio).", "The extracted DNA was resuspended in DNase-, RNase- and proteinase-free water.", "To amplify the entire genome, three pairs of PCV2 specific primers were used to amplify three overlapping fragments: primer pair PCV2.2B (5′-TCCGAAGACGAGCGCA-3′, set forth in SEQ ID NO:27) and PCV2.2A (5′-GAAGTAATCCTCCGATAGAGAGC-3′, set forth in SEQ ID NO:28), primer pair PCV2.3B (5′-GTTACAAAGTTATCATCTAGAATAACAGC-3′, set forth in SEQ ID NO:29) and PCV2.3A (5′-ATTAGCGAACCCCTGGAG-3′, set forth in SEQ ID NO:30), and primer pair PCV2.4B (5′-AGAGACTAAAGGTGGAACTGTACC-3′, set forth in SEQ ID NO:31) and PCV2.4A (5′-AGGGGGGACCAACAAAAT-3′, set forth in SEQ ID NO:32).", "The PCR reaction consisted of 38 cycles of denaturation at 94° C. for 1 min, annealing at 46° C. for 30 sec, and extension at 72° C. for 2 min, followed by a final extension at 72° C. for 7 min.", "The PCR products of expected size were excised from 0.8% agarose gels followed by purification with a Geneclean Kit (Bio 101, Inc., La Jolla, Calif.).", "The PCR products were directly sequenced for both strands using the PCR primers.", "The nucleotide and amino acid sequences were compiled and analyzed with the publicly accessible MacVector program (Oxford Molecular Ltd., Beaverton, Oreg.)", "using Clustal alignment.", "The complete sequence of PCV2 VP120 was compared to PCV2 VP1 and 91 other PCV2 isolates as well as 4 PCV1 isolates available in the GenBank database.", "(5) Experimental Characterization of the Serially-Passaged PCV2 VP120, and VP1.To determine the pathogenic potential of the VP120 PCV2, thirty-one SPF pigs of 3 to 4 weeks of age were randomly assigned to 3 groups, and housed separately.", "Prior to the inoculation, serum samples from all piglets were tested by PCR for the presence of PCV1 or PCV2 DNA.", "To maximize the efficiency of inoculation, each pig was inoculated with 1 ml of the inoculum intramuscularly and 3 ml intranasally.", "The ten pigs in Group 1 were each inoculated with PBS buffer as negative controls.", "Eleven pigs in Group 2 each received 104.9 TCID50 of PCV2 VP120, and ten pigs in Group 3 each received 104.9 TCID50 of PCV2 VP1.All pigs were monitored for clinical signs of disease.", "Serum samples were collected from each pig at −1, 7, 14, 21, 28, 35 and 42 days post inoculation (DPI).", "At 21 DPI, 5 randomly selected pigs from each group were necropsied.", "The remaining pigs in each group were necropsied at 42 DPI.", "(6) Clinical Evaluation.", "Pigs were weighed at −1, 7, 14, 21, 28, 35 and 42 DPI.", "Rectal temperatures and clinical scores, ranging from 0 to 6 (0=normal; 6=severe) (M. Fenaux et al., 2002, supra), were recorded every other day from 0 to 42 DPI.", "Clinical observations, including evidence of central nervous system disease, liver disease (icterus), musculoskeletal disease, and changes in body condition, were recorded at two-day intervals.", "All clinical evaluations were performed by a team of two people to confirm observations.", "(7) Gross Pathology and Histiopathology.", "Complete necropsies were performed on all pigs.", "The necropsy team was blinded to the infection status of the pigs.", "The percentage of lung with grossly visible pneumonia was estimated for each pig based on a previously described scoring system (M. Fenaux et al., 2002, supra).", "Lesions such as the enlargement of the lymph nodes (ranging from 0 for normal to 3 for three times normal size) were scored separately.", "Sections for histopathologic examination were taken from the nasal turbinate, lungs (five sections, see M. Fenaux et al., 2002, supra), heart, brain, lymph nodes (tracheobronchial, iliac, mesenteric, subiliac, and superficial inguinal), tonsil, liver, thymus, spleen, pancreas, and kidney.", "The tissues were examined in a blinded fashion and given a subjective score for severity of lung, lymph node, and liver lesions (M. Fenaux et al., 2002, supra).", "Lung scores ranged from 0 (normal) to 3 (severe lymphohistiocytic interstitial pneumonia).", "Liver scores ranged from 0 (normal) to 3 (severe lymphohistiocytic interstitial hepatitis).", "Lymph node scores were an estimated amount of lymphoid depletion of follicles ranging from 0 (normal or no lymphoid depletion) to 3 (severe lymphoid depletion and histiocytic replacement of follicles) (M. Fenaux et al., 2002, supra).", "(8) Serology.", "Blood samples were collected from all pigs at −1, 7, 14, 21, 28, 35, and 42 DPI.", "Serum antibodies to PCV2 were detected by a modified indirect ELISA based on the recombinant ORF2 capsid protein of PCV2 (P. Nawagitgul et al., 2002, supra).", "Serum samples with a sample/positive (S/P) ratio above 0.2 were considered seropositive for PCV2.", "(9) Quantitative Real-Time PCR.", "Quantitative real-time PCR was performed to determine PCV2 virus loads in serum samples collected at −1, 7, 14, 21, 28, 35, and 42 DPI and in lymphoid tissue samples collected at 21 DPI and 42 DPI.", "Primer pair MCV1 (5′-GCTGAACTTTTGAAAGTGAGCGGG-3′, set forth in SEQ ID NO:17) and MCV2 (5′-TCACACAGTCTCAGTAGATCATCCCA-3′, set forth in SEQ ID NO:18) (M. Fenaux et al., 2000, supra) was used for the quantitative real-time PCR.", "The PCR reaction was performed in the presence of intercalating SYBR green dye (Molecular Probes, Inc. Eugene, Oreg.)", "as described herein.", "A standard dilution series with a known amount of pBluescript plasmid containing a single copy of the PCV2 genome (M. Fenaux et al., 2002, supra) was run simultaneously in each real-time PCR reaction to quantify the virus genomic copy numbers.", "(10) Immunohistochemistry (IHC).", "IHC detection of PCV2 specific antigen was performed on lymph node, spleen, tonsil and thymus tissues collected during necropsy at 21 and 42 DPI as described hereinabove (M. Fenaux et al., 2002, supra).", "The amount of PCV2 antigen distributed in the lymphoid tissues was scored in a blinded fashion by assigning a score of 0, if no signal, to 3 for a strong positive signal (S. D. Sorden et al., “Development of a polyclonal-antibody-based immunohistochemical method for the detection of type 2 porcine circovirus in formalin-fixed, paraffin-embedded tissue,” J. Vet.", "Diagn.", "Invest.", "11:528-530 (1999)).", "(11) Statistical Analysis.", "All statistical analyses were performed using the SAS®-system (Version 8.02, SAS institute Inc. Cary N.C. 27513).", "Growth characteristics of viruses were compared by regressive analyses using the GLM procedure.", "Serum samples S/P ratios were compared by analysis of variance, with the MIXED procedure.", "The model included effects of inoculum, DPI, and their interaction.", "S/P ratios were dichotomized to presence/absence of seroconversion at S/P=0.20 and analyzed by logistic regression using the method of generalized equations in the SENROD procedure.", "Mean viral genomic copy numbers in serum and lymph nodes of piglets in Groups 2 and 3 were compared by the Kruskal-Wallis test using the NPAR1WAY procedure and/or by analysis of variance of ranked data, followed by a Bonferroni test of multiple mean ranks, using the GLM procedure.", "Serology and viremia data were analyzed for all pigs up to 21 DPI, and separately for those pigs necropsied at 42 DPI.", "Clinical sign scores were dichotomized to presence/absence of clinical signs for each examination date, and per pig over the entire period of study and compared between groups by Fisher's Exact test using the FREQ procedure, and by logistic regression using LOGISTIC procedure.", "Gross pathologic and histopathologic scores were compared by the Kruskal-Wallis test using the NPAR1WAY procedure and/or by analysis of variance using the GLM procedure, followed by a Bonferroni test of multiple means.", "Proportion of pigs with gross and histopathologic lesions in various tissues was compared between groups by Fisher's Exact Test using the FREQ procedure.", "Example 21 Comparison of the Replication of PCV2 VP120 and PCV2 VP1 in PK-15 Cells To determine the growth characteristics of PCV1, PCV2 VP1 and VP120, one-step growth curves were performed in duplicate simultaneously for PCV1, PCV2 VP1 and PCV2 VP120.The infectious titers of viruses collected at 12 hour intervals were determined by IFA (FIG.", "12).", "The initial titers after infection at 12 h postinoculation were about 101.5 TCID50/ml for all three viruses.", "The infectious titers of PCV1 and PCV2 VP120 compared to PCV2 VP1 increased differently (p=0.0053) from 12 to 96 h. By 96 h postinfection, PCV1 and PCV2 VP120 had titers of 103.66 and 103.75 TCID50/ml, whereas the PCV2 VP1 was 102.83 TCID50/ml (FIG.", "12).", "It was demonstrated that PCV2 VP120 surprisingly replicated more efficiently in PK-15 cells than PCV2 VP1.Example 22 Identification of Two Amino Acid Mutations within the PCV2 Capsid Protein During Serial Passages The complete genomes of PCV2 passage numbers 1, 30, 60, 90, and 120 were amplified and sequenced.", "Sequence analyses revealed that there were a total of 2 nucleotide and 2 amino acid mutations in the entire genome after 120 passages.", "The first mutation appeared in passage 30 (VP30) in which a proline was substituted for an alanine at position 110 of the capsid (P110A) (FIG.", "13).", "This mutation was also present during the remaining passages.", "A second mutation from arginine to serine at position 191 of the capsid (R191S) was identified at passage 120 but not in lower passages (FIG.", "13).", "The amino acid mutations were the result of the corresponding mutations that occurred in the genome in nucleotide positions 328 (C to G) and 573 (A to C).", "In position 328 of the nucleotide sequence, cytosine changes to guanine (C to G) leading to the amino acid change of P110A.", "In position 573, adenine changes to cytosine (A to C) leading to the second amino acid change of R191S.", "By comparing all known PCV1 and PCV2 sequences in the Genbank including 91 PCV2 and 4 PCV1 isolates, it was found that that the P110A mutation is unique (FIG.", "13) as all known PCV1 and PCV2 isolates have a proline at residue 110 of the capsid protein.", "The serine in the R191S mutation is also unique.", "However, the amino acid in the 191 position is often variable: PCV2 isolates of North American origin have an arginine, PCV2 isolates of Canadian and French origins have glycine, and PCV2 isolates of Spanish, Taiwanese and German origins have an alanine.", "All nonpathogenic PCV1 isolates have a threonine residue (FIG.", "13).", "Example 23 Comparison of the Viremia Length and Virus Loads of PCV2 VP120 Virus and PCV2 VP1 Virus in Sera of Infected Pigs Serum samples were collected from all control and inoculated pigs at −1, 7, 14, 21, 28, 35, and 42 DPI and assayed for PCV2 viremia by quantitative real-time PCR and for anti-PCV2 antibody by ELISA.", "Prior to inoculation at −1 DPI, serum samples from all pigs were tested negative for PCV2 DNA.", "The Group 1 negative control pigs were negative for PCV2 viremia throughout the study (see Table 11, below).", "All pigs in Group 1 had detectable PCV2 maternal antibodies at −1 DPI, which all waned by 21 DPI.", "Seroconversion to PCV2 was not detected in any of the ten negative control pigs (see Table 12, below).", "In the PCV2 VP120 inoculated Group 2 pigs, viremia was first detected in one of eleven pigs at 7 DPI (Table 11, FIG.", "14).", "A total of 4 pigs in Group 2 were viremic during the study.", "The average length of continuous viremia was 1.6 weeks.", "By 35 DPI, all Group 2 pigs seroconverted to PCV2 (Table 12).", "In the PCV2 VP1 inoculated Group 3 pigs, viremia was first detected in seven of ten pigs at 7 DPI (Table 11, FIG.", "14).", "Nine out of the ten pigs in Group 3 became viremic for PCV2 during the study and the average length of continuous viremia was 3 weeks.", "All animals in Group 3 seroconverted to PCV2 by 35 DPI (Table 12).", "The range of PCV2 genomic copy numbers per ml of serum in positive samples was 8,840 to 274,800 in PCV2 VP120 inoculated Group 2 pigs, and 26,520 to 120,000,000 in PCV2 VP1 inoculated Group 3 pigs (FIG.", "14).", "PCV2 genomic copy loads per ml of serum were greater in Group 3 than that in Group 2 pigs up to 21 DPI (p=0.0003) and 42 DPI (p=0.039).", "However, PCV2 DNA was recovered from lymph nodes of only 3/11 Group 2 and 2/10 Group 3 pigs, and the median PCV2 genomic copy loads per mg of tracheobronchial lymph node (TBLN) did not differ between Groups 2 and 3 (p=0.72).", "The virus recovered from the sera and TBLN of 4 selected pigs in Groups 2 and 3 were sequenced, and sequence analyses revealed that the recovered viruses originated from the inocula.", "The S/P ratios of PCV2 antibodies differed between Groups 1, 2 and 3 (p<0.0001) and over time (p<0.0001).", "It was shown that the PCV2 VP120 virus significantly reduced viremia length and virus loads in sera of infected pigs compared to the PCV2 VP1 virus.", "TABLE 11 Detection of Viremia by Real-Time PCR in Sera of Inoculated and Control Pigs No.", "of pigs positive/no.", "testeda Days post inoculation Grp.", "Inocula −1 7 14 21 28 35 42 total 1 Control 0/10 0/10 0/10 0/10 0/5 0/5 0/5 0/10 2 PCV2 VP120 0/11 1/11 2/11 3/11 0/6 1/6 1/6 4/11 3 PCV2 VP 1 0/10 7/10 8/10 8/10 3/5 3/5 1/5 9/10 aFive pigs per group were necropsied at 21 day post inoculation (DPI) and the remaining pigs were necropsied at 42 DPI.", "TABLE 12 Seroconversion to PCV2 Antibodies in Pigs Inoculated with PCV2 Passages 1 (VP1) and 120 (VP120) No.", "of pigs positive/no.", "testeda Days post inoculation Grp.", "Inoculum −1 7 14 21 28 35 42 1 Control 10/10 b 1/10 1/10 0/10 0/5 0/5 0/5 2 PCV2 VP120 3/15 b 0/11 0/11 0/11 0/6 6/6 6/6 3 PCV2 VP 1 1/10 b 0/10 1/10 2/10 4/5 5/5 5/5 aFive pigs per group were necropsied at 21 day post inoculation (DPI) and the remaining pigs were necropsied at 42 DPI.", "b Maternal antibodies were detectable at −1 DPI but waned in all groups between 7 and 21 DPI.", "Example 24 Attenuation of PCV2 VP120 Virus in Pigs Mild clinical signs (sneezing and rough coat) were noted in some animals from all three groups.", "Two of 10 non-inoculated, and all of 21 inoculated pigs developed clinical signs (p=0.051).", "Up to 21 DPI, Groups 2 and 3 pigs were 58 (95% C.I.", ": [13.1; 255.0]) and 41 [9.3;178.0] times more likely to show mild clinical signs at any examination date than negative control pigs, with no difference between pigs of Groups 2 and 3 (OR3vs2: 1.4[0.8;2.6]).", "For the 16 pigs that were necropsied at 42 DPI, when evaluated over the entire study period, Groups 2 and 3 pigs again were more likely to show mild clinical signs than negative control pigs (OR2vs1: 20.4[4.6;90.1]; OR3vs1: 71.6 [16.0;320.8]) with Group 3 pigs being 3.5 [1.9;6.6] times more likely to show mild clinical signs than Group 2 pigs.", "There were no differences in weight gain (p=0.081) or mean rectal temperatures (p>0.05) among any of the groups.", "At necropsies, lymph nodes of 2/5 pigs in Group 1 were mildly enlarged, however this was not associated with PCV2 infection as evidenced by the lack of PCV2 DNA or seroconversion.", "At 42 DPI necropsy, all Group 1 pigs had normal lymph nodes (see Table 13, below).", "Group 2 pigs inoculated with PCV2 VP120 had mild to moderately enlarged lymph nodes at both 21 and 42 DPI (Table 13).", "The lymph nodes in Group 3 pigs were moderately to severely enlarged at both 21 and 42 DPI (Table 13).", "Pigs inoculated with PCV2 VP1 had visible gross pneumonia at 21 DPI.", "Visible gross pneumonia was not found in Group 1 or 2 pigs at either 21 or 42 DPI.", "Microscopic lung lesions characterized by mild peribronchiolar lymphoplasmacytic and histiocytic bronchointerstitial pneumonia and liver lesions characterized by mild lymphoplasmacytic hepatitis were detected in pigs of all groups (see Table 14, below).", "Mild lymphoid depletion (LD) of lymph node follicles was detected in 0/5 Group 1 pigs at 21 and 42 DPI, in 3/5 (21 DPI) and in 2/6 (42 DPI) Group 2 pigs, in 4/5 (21 DPI) and 5/5 (42 DPI) Group 3 pigs (Table 14).", "Mild histiocytic replacement (HR) of lymph node follicles was not observed in Group 1 pigs.", "In Group 2, mild HR was observed in the lymph nodes of 0/5 pigs at 21 DPI and 2/6 pigs at 42 DPI.", "In Group 3, mild to moderate HR of the lymph nodes was observed in 3/5 pigs at both 21 and 42 DPI.", "The tonsil and spleen tissue follicles of the Group 1 pigs were free of LD and HR at 21 or 42 DPI.", "Mild LD of the tonsil follicles was found in 2/5 pigs in Group 2 at 21 DPI.", "Mild to moderate LD of the tonsil follicles was found in 2/5 pigs in Group 3 at 21 DPI and mild HR of the tonsil tissue in 1/5 pigs in Group 3 at both 21 and 42 DPI.", "Mild LD of the spleen follicles was observed in 2/5 and 1/6 pigs in Group 2 at 21 and 42 DPI, respectively.", "Mild to moderate LD of the spleen follicles was noted in 4/5 in Group 3 pigs at both 21 and 42 DPI.", "In Group 2 pigs, mild HR of the spleen tissue follicles was found in 1/6 pigs at 42 DPI.", "In Group 3, 4/5 pigs at 21 DPI and 3/5 pigs at 42 DPI had mild to moderate HR of the spleen tissue follicles (Table 14).", "Presence of lesions in other tissues and organs are summarized in Table 14.At necropsies (21 and 42 DPI), PCV2 antigen was not detected by IHC in the lymphoid tissues of the negative control Group 1 pigs.", "In the PCV2 VP120 inoculated Group 2, low amounts of PCV2 antigen was detected in spleen tissues of 1/5 pigs at 21 DPI, in lymph node tissues of 2/6 pigs at 42 DPI, and in tonsil tissues of 3/6 pigs at 42 DPI (see Table 15, below).", "In the PCV2 VP0 inoculated Group 3, low-to-high amounts of PCV2 antigen were detected in lymph node tissues of 5/5 pigs, in tonsil tissues of 4/5 pigs, and in spleen tissues of 4/5 pigs at 21 DPI.", "At 42 DPI, low-to-moderate amounts of PCV2 antigen were detected in PCV2 VP0 inoculated Group 3 (Table 15).", "All gross pathologic and histopathologic scores at 21 DPI and 42 DPI were compared by analysis of variance using the GLM procedure followed by a Bonferroni test of multiple means.", "At 21 DPI, Groups 1 and 2 mean scores are similar (p=1.00) but differ from the mean scores of Group 3 (p=0.0032).", "By 42 DPI, the mean scores of Group 1 differ from Group 2 (p=0.0083) and Group 3 (p=0.0001), and the Group 2 mean scores are milder than those of Group 3 (p=0.0274) (Tables 13-15).", "TABLE 13 Gross Lymph Node and Lung Lesions in Control and Inoculated Pigs No.", "of pigs with enlarged No.", "of pigs with gross lymph nodesa pneumonia lesions Group Inoculum 21 DPI 42 DPI 21 DPI 42 DPI 1 Control 2/5(0.4b)Ic 0/5(0.0)I 0/5(0.0)I 0/5(0.0) 2 PCV2 VP120 2/5(0.4)I 4/6(1.3)II 0/6(0.0)I 0/5(0.0) 3 PCV2 VPI 5/5(2.2)II 5/5(2.6)II 2/5(2.6)II 0/5(0.0) aFive pigs from each group was necropsied at 21 days post inoculation (DPI) and the remaining pigs were necropsied at 42 DPI.", "bValues in parentheses are the mean scores of estimated lymph node enlargement (0 = normal to 3 severely enlarged and discolored) and mean percentage of lungs affected by gross visible pneumonia (0-100%) cDifferent superscripts (I, II) indicate different mean value score between groups (p < 0.05).", "TABLE 14 Distribution of Histopathological Lesions in Different Tissues and Organs from Control and Inoculated Pigs No.", "of pigs positive/no.", "of pigs tested Lymph nodes Tonsil Spleen Group Inocula DPIa Lung LD¶c HR LD† HR LD¶ HR† Liver Kidney Heart 1 Control 21 0/5(0.0)b 0/5(0.0) 0/5(0.0) 0/5(0.0) 0/5(0.0) 0/5(0.0) 0/5(0.0) 0/5(0.0) 1/5 1/5 42 3/5(0.6) 0/5(0.0) 0/5(0.0) 0/5(0.0) 0/5(0.0) 0/5(0.0) 0/5(0.0) 1/5(0.2) 1/5 0/5 2 PCV2 21 2/5(0.4) 3/5(0.6) 0/5(0.0) 2/5(0.4) 0/5(0.0) 2/5(0.4) 0/5(0.0) 3/5(0.6) 2/5 0/5 VP120 42 5/6(1.0) 2/6(0.3) 2/6(0.3) 0/6(0.0) 0/6(0.0) 1/6(0.2) 1/6(0.2) 0/6(0.0) 2/6 0.5 3 PCV2 21 2/5(0.4) 4/5(1.2) 3/5(1.0) 5/5(1.2) 1/5(0.2) 4/5(1.0) 4/5(1.0) 3/5(1.2) 3/5 3/5 VP0 42 5/5(1.4) 5/5(1.4) 3/5(0.8) 0/5(0.0) 1/5(0.2) 4/5(1.0) 3/5(0.6) 3/6(0.6) 1/5 2/5 aDPI, Days postinoculation bValues in parentheses are mean histological scores for interstitial pneumonia and for interstitial hepatitis and lymphoid depletion (LD) and histiocytic replacement (HR) for lymph nodes, tonsils and spleen.", "cIndicates difference (p < 0.05) using Fisher's Exact test between Groups 1, 2, and 3 in severity of respective histopathological lesion with symbol †at 21 DPI and symbol ¶at 42 DPI necropsies.", "TABLE 15 Immunohistiochemical Detection of PCV2 Antigen in Lymph Nodes, Tonsils and Spleen of Inoculated and Control Pigs No.", "of pigs positive/no.", "testedb Group Inocula DPIa Lymph node†b Tonsil† Spleen 1 Control 21 0/5 (0.0)c 0/5 (0.0) 0/5 (0.0) 42 0/5 (0.0) 0/5 (0.0) 0/5 (0.0) 2 PCV2 VP120 21 0/5 (0.0) 0/5 (0.0) 1/5 (0.2) 42 2/6 (0.3) 3/6 (0.5) 0/6 (0.0) 3 PCV2 VPI 21 5/5 (1.6) 4/5 (1.0) 4/5 (1.2) 42 3/5 (0.8) 2/5 (0.4) 2/5 (0.4) aDP1, days postinoculation bIndicates difference (p < 0.05) using Fisher's Exact test between Groups 1, 2, and 3 of PCV2 antigen presence in respective tissues with symbol † at 21 DPI.", "cValue in parentheses are the mean scores of the amounts of PCV2 antigen in lymphoid tissues (ranging from 0, no antigen detected, to 3, high levels of antigen).", "In the foregoing, there has been provided a detailed description of particular embodiments of the present invention for the purpose of illustration and not limitation.", "It is to be understood that all other modifications, ramifications and equivalents obvious to those having skill in the art based on this disclosure are intended to be included within the scope of the invention as claimed." ] ]
Patent_15875892
[ [ "SYSTEMS AND METHODS FOR CONTROLLING EMAIL ACCESS", "Embodiments of the disclosure relate to proxying at least one email resource from at least one email service to at least one client device, determining whether the email resources are accessible to the client devices via at least one unauthorized application on the client devices, and modifying the email resources to be inaccessible via the unauthorized applications on the client devices in response to a determination that the email resources are accessible via the unauthorized applications on the client devices." ], [ "1.A method for managing access to content associated with email by an access control server, comprising: obtaining an email message for transmission to a client, the email message obtained from an email server, wherein the access control server is configured to proxy email messages from the email server to a client device; determining that access to the email message should be restricted to an authorized email client installed on the client device; generating a modified email message based upon the email message, wherein access to content of the modified email message is inaccessible by an unauthorized application installed on the client device; and transmitting the modified email message to the client device, wherein access to the email message is restricted to the authorized email client installed on the client device.", "2.The method of claim 1, wherein generating the modified email message further comprises: removing a portion of a body of the email message from the modified email message; encrypting the portion of the body of the email message; and including the encrypted portion of the body to the modified email message.", "3.The method of claim 1, further comprising transmitting at least one instruction to the client device, wherein the at least one instruction comprises an encryption key with which the modified email message can be decrypted by the authorized email client.", "4.The method of claim 3, wherein the encryption key is inaccessible to the unauthorized application installed on the client device.", "5.The method of claim 1, wherein determining that access to the email message should be restricted to the authorized email client comprises determining that a content-type resource rule specifies that a particular keyword appears in at least one of a body or an attachment of the email message.", "6.The method of claim 1, wherein determining that access to the email message should be restricted to the authorized email client comprises determining that a property of a sender of the email message is associated with a particular domain, a particular username, or a particular email address.", "7.The method of claim 1, wherein generating the modified email message further comprises: removing an attachment from the email message; generating a modified attachment by at least one of encrypting the attachment or modifying a file format of the attachment; and including the modified attachment as an attachment to the modified email message.", "8.A non-transitory computer-readable medium comprising a program which, when executed by a processor, manage access to content associated with email by an access control server and caused the processor to at least: obtain an email message for transmission to a client, the email message obtained from an email server, wherein the access control server is configured to proxy email messages from the email server to a client device; determine that access to the email message should be restricted to an authorized email client installed on the client device; generate a modified email message based upon the email message, wherein access to content of the modified email message is inaccessible by an unauthorized application installed on the client device; and transmit the modified email message to the client device, wherein access to the email message is restricted to the authorized email client installed on the client device.", "9.The non-transitory computer-readable medium of claim 8, wherein the modified email message is generated by: removing a portion of a body of the email message from the modified email message; encrypting the portion of the body of the email message; and including the encrypted portion of the body to the modified email message.", "10.The non-transitory computer-readable medium of claim 8, wherein the program, when executed, transmits at least one instruction to the client device, wherein the at least one instruction comprises an encryption key with which the modified email message can be decrypted by the authorized email client.", "11.The non-transitory computer-readable medium of claim 10, wherein the encryption key is inaccessible to the unauthorized application installed on the client device.", "12.The non-transitory computer-readable medium of claim 8, wherein the program determines that access to the email message should be restricted to the authorized email client by determining that a content-type resource rule specifies that a particular keyword appears in at least one of a body or an attachment of the email message.", "13.The non-transitory computer-readable medium of claim 8, wherein the program determines that access to the email message should be restricted to the authorized email client by determining that a property of a sender of the email message is associated with a particular domain, a particular username, or a particular email address.", "14.The non-transitory computer-readable medium of claim 8, wherein the program generates the modified email message by: removing an attachment from the email message; generating a modified attachment by at least one of encrypting the attachment or modifying a file format of the attachment; and including the modified attachment as an attachment to the modified email message.", "15.An access control server that manages access to content associated with email by an access control server, the access control server executing an application that is configured to at least: obtain an email message for transmission to a client, the email message obtained from an email server, wherein the access control server is configured to proxy email messages from the email server to a client device; determine that access to the email message should be restricted to an authorized email client installed on the client device; generate a modified email message based upon the email message, wherein access to content of the modified email message is inaccessible by an unauthorized application installed on the client device; and transmit the modified email message to the client device, wherein access to the email message is restricted to the authorized email client installed on the client device.", "16.The access control server of claim 15, wherein the modified email message is generated by: removing a portion of a body of the email message from the modified email message; encrypting the portion of the body of the email message; and including the encrypted portion of the body to the modified email message.", "17.The access control server of claim 15, wherein the application, when executed, transmits at least one instruction to the client device, wherein the at least one instruction comprises an encryption key with which the modified email message can be decrypted by the authorized email client.", "18.The access control server of claim 17, wherein the encryption key is inaccessible to the unauthorized application installed on the client device.", "19.The access control server of claim 15, wherein the program determines that access to the email message should be restricted to the authorized email client by determining that a content-type resource rule specifies that a particular keyword appears in at least one of a body or an attachment of the email message.", "20.The access control server of claim 15, wherein the program determines that access to the email message should be restricted to the authorized email client by determining that a property of a sender of the email message is associated with a particular domain, a particular username, or a particular email address." ], [ "<SOH> BACKGROUND <EOH>Controlling email access is critical to ensure that email resources may only be accessed by authorized parties in authorized manners.", "To date, enterprises have utilized access credentials to control which, if any, parties may access email resources.", "This method may ensure that only authorized parties may access email resources.", "However, this method fails to control how those email resources may be accessed by the proper recipients.", "This method further fails to modify the email resources to comply with enterprise security standards.", "As enterprises seek to protect sensitive information, systems and methods for controlling email access are necessary to ensure that email resources may only be accessed by authorized parties in authorized manners." ], [ "<SOH> BRIEF SUMMARY <EOH>Some or all of the above needs and/or problems may be addressed by certain embodiments of the disclosure.", "Certain embodiments may include systems and methods for controlling access to networks.", "According to one embodiment of the disclosure, there is disclosed a system.", "The system can include at least one client device.", "The system can also include at least one email service.", "The system can further include at least one memory that stores computer-executable instructions.", "The system can yet further include a processor configured to access the at least one memory.", "The processor is configured to execute the computer-executable instructions to perform a method including the steps of proxying email resources from email services to client devices, determining whether the email resources are accessible via unauthorized applications on the client devices, and configuring the email resources to be inaccessible via unauthorized applications on the client devices in response to a determination that the email resources are accessible via unauthorized applications on the client devices.", "According to another embodiment of the disclosure, there is disclosed a method.", "The method can include identifying email resources on client devices, determining whether the email resources are accessible via unauthorized applications on the client devices, and configuring the email resources to be inaccessible via unauthorized applications on the client devices in response to a determination that the email resources are accessible via unauthorized applications on the client devices.", "Further, according to another embodiment of the disclosure, there is disclosed a non-transitory computer-readable medium embodying a program executable in a computing device, the program comprising code that, when executed by a computing device, causes the computing device to perform a method comprising the steps of identifying email resources, determining whether the email resources are accessible via unauthorized applications on client devices, and configuring the email resources to be inaccessible via unauthorized applications on client devices in response to a determination that the email resources are accessible via unauthorized applications on client devices.", "Other embodiments, systems, methods, apparatus aspects, and features of the disclosure will become apparent to those skilled in the art from the following detailed description, the accompanying drawings, and the appended claims." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. application Ser.", "No.", "14/687,394, filed Apr.", "15, 2015, which is a continuation of U.S. application Ser.", "No.", "13/750,887, filed Jan. 25, 2013, which has issued as U.S. Pat.", "No.", "9,021,037, which is a continuation-in-part of U.S. application Ser.", "No.", "13/706,499, filed on Dec. 6, 2012, which has issued as U.S. Pat.", "No.", "8,978,110, the contents of both of which are hereby expressly incorporated by reference in their entireties.", "FIELD OF THE INVENTION Embodiments of the disclosure relate generally to data security, and more particularly, to systems and methods for controlling email access.", "BACKGROUND Controlling email access is critical to ensure that email resources may only be accessed by authorized parties in authorized manners.", "To date, enterprises have utilized access credentials to control which, if any, parties may access email resources.", "This method may ensure that only authorized parties may access email resources.", "However, this method fails to control how those email resources may be accessed by the proper recipients.", "This method further fails to modify the email resources to comply with enterprise security standards.", "As enterprises seek to protect sensitive information, systems and methods for controlling email access are necessary to ensure that email resources may only be accessed by authorized parties in authorized manners.", "BRIEF SUMMARY Some or all of the above needs and/or problems may be addressed by certain embodiments of the disclosure.", "Certain embodiments may include systems and methods for controlling access to networks.", "According to one embodiment of the disclosure, there is disclosed a system.", "The system can include at least one client device.", "The system can also include at least one email service.", "The system can further include at least one memory that stores computer-executable instructions.", "The system can yet further include a processor configured to access the at least one memory.", "The processor is configured to execute the computer-executable instructions to perform a method including the steps of proxying email resources from email services to client devices, determining whether the email resources are accessible via unauthorized applications on the client devices, and configuring the email resources to be inaccessible via unauthorized applications on the client devices in response to a determination that the email resources are accessible via unauthorized applications on the client devices.", "According to another embodiment of the disclosure, there is disclosed a method.", "The method can include identifying email resources on client devices, determining whether the email resources are accessible via unauthorized applications on the client devices, and configuring the email resources to be inaccessible via unauthorized applications on the client devices in response to a determination that the email resources are accessible via unauthorized applications on the client devices.", "Further, according to another embodiment of the disclosure, there is disclosed a non-transitory computer-readable medium embodying a program executable in a computing device, the program comprising code that, when executed by a computing device, causes the computing device to perform a method comprising the steps of identifying email resources, determining whether the email resources are accessible via unauthorized applications on client devices, and configuring the email resources to be inaccessible via unauthorized applications on client devices in response to a determination that the email resources are accessible via unauthorized applications on client devices.", "Other embodiments, systems, methods, apparatus aspects, and features of the disclosure will become apparent to those skilled in the art from the following detailed description, the accompanying drawings, and the appended claims.", "BRIEF DESCRIPTION OF THE DRAWINGS The detailed description is set forth with reference to the accompanying drawings, which are not necessarily drawn to scale.", "The use of the same reference numbers in different figures indicates similar or identical items.", "FIG.", "1 illustrates a block diagram of a networked environment according to certain embodiments of the disclosure.", "FIG.", "2 illustrates a flow diagram of exemplary functionality performed by an access control service executed by an access control server in the networked environment of FIG.", "1 according to certain embodiments of the present disclosure.", "FIG.", "3 illustrates a flow diagram of exemplary functionality performed by a client side application executed by a client device in the networked environment of FIG.", "1 according to certain embodiments of the present disclosure.", "FIGS.", "4-5 are exemplary user interfaces rendered by an access control service executed by an access control server in the networked environment of FIG.", "1 according to certain embodiments of the present disclosure.", "FIGS.", "6-11 are exemplary user interfaces rendered by a client side application executed by a client device in the networked environment of FIG.", "1 according to certain embodiments of the present disclosure.", "FIG.", "12 illustrates a block diagram of a networked environment according to certain embodiments of the disclosure.", "FIG.", "13 illustrates a flow diagram of exemplary functionality performed by an access control service executed by an access control server in the networked environment of FIG.", "12 according to certain embodiments of the present disclosure.", "FIG.", "14 illustrates a block diagram of a networked environment according to certain embodiments of the disclosure.", "FIG.", "15 illustrates a flow diagram of exemplary functionality performed by an access control service executed by an access control server in the networked environment of FIG.", "14 according to certain embodiments of the present disclosure.", "FIG.", "16 illustrates a flow diagram of exemplary functionality performed by a client side application executed by a client device in the networked environment of FIGS.", "12 and 14 according to certain embodiments of the present disclosure.", "FIG.", "17 illustrates schematic block diagrams of an access control server and a client device employed in the network environments of FIGS.", "1, 12 and 14 according to certain embodiments of the disclosure.", "DETAILED DESCRIPTION Illustrative embodiments of the disclosure will now be described more fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments of the disclosure are shown.", "The disclosure may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that this disclosure will satisfy applicable legal requirements.", "As noted above, like numbers refer to like elements throughout.", "Illustrative embodiments of the disclosure are directed to, among other things, controlling access to email.", "As an overview, access to email may be controlled by limiting access of proper recipients to specific email resources and by limiting the manner in which the proper recipients access the specific email resources.", "In certain embodiments, the email resources may be modified to satisfy enterprise security standards and/or access restrictions.", "The technical effects of certain embodiments of the disclosure may include preventing unauthorized access to email resources and eliminating costs associated with sensitive information loss.", "Moreover, the technical effects of certain embodiments of the invention may include modifying email resources to satisfy access restrictions.", "FIG.", "1 depicts certain illustrative components for a networked environment 100 according to various embodiments.", "In certain embodiments, the networked environment 100 may include a network 110, a client device 120, and an access control server 150.In some embodiments, the network 110 may be or include, for example, any type of wireless network such as a wireless local area network (WLAN), a wireless wide area network (WWAN), and/or the like.", "Additionally, the network 110 may be or include the Internet, intranets, extranets, microwave networks, satellite communications, cellular systems, PCS, infrared communications, global area networks, and/or any combination of two or more such networks.", "In one embodiment, the network 110 facilitates access to email resources 165 for at least one client device 120, where access to the email resources 165 is controlled by an access control server 150.The client device 120 may comprise, for example, a cellular telephone, a smartphone and/or personal digital assistant, a tablet computer and/or web pad, a laptop computer, a desktop computer, a set-top box, a music player, a game console, and/or another device with like capability.", "For purposes of convenience, the client device 120 is referred to herein in the singular.", "Even though the client device 120 is referred to in the singular, it is understood that at least one client device 120 may be employed in the arrangements as descried herein.", "The client device 120 may include a wired network connectivity component (not shown in FIG.", "1), for example, an Ethernet network adapter, a modem, and/or the like.", "The client device 120 may further include a wireless network connectivity interface (not shown in FIG.", "1), for example, a PCI (Peripheral Component Interconnect) card, USB (Universal Serial Bus) interface, PCMCIA (Personal Computer Memory Card International Association) card, SDIO (Secure Digital Input-Output) card, NewCard, Cardbus, a modem, a wireless radio transceiver, and/or the like.", "The client device 120 may be operable to communicate via wired connection with the access control server 150 with the aid of the wired network connectivity component.", "The client device 120 may be further operable to communicate wirelessly with the access control server 150 with the aid of the wireless network connectivity component.", "The client device 120 may comprise a memory for storing data and applications, a processor for executing applications stored in memory, a display 136 upon which the processor may execute at least one user interface 137, and a local interface such as a bus, as will be described with respect to FIG.", "12.The memory of the client device 120 may comprise a data store 122.The data store 122 of the client device 120 may include a device profile 123.In one embodiment, the device profile 123 may represent hardware, software, and security attributes that describe the state of the client device 120.For instance, the device profile 123 may represent hardware specifications of the client device 120, version and configuration information of various software programs and hardware components installed on the client device 120, transport protocols enabled on the client device 120, version and usage information of various other resources stored on the client device 120, and/or any other attributes associated with the state of the client device 120.In another embodiment, the device profile 123 may further include characteristics describing the state of the client device 120, including indications of the location of the client device 120, the current time associated with the client device 120, the client device's 120 detection of at least one network beacon associated with at least one network 110, and the signal strength of the network beacons received by the client device 120.In yet another embodiment, the device profile 123 may include data indicating a date of a last virus scan of the client device 120, a date of a last access and/or service by an Information Technology (IT) representative, a date of a last access by an access control service 174, and/or any other data indicating a date of last maintenance of the client device 120.Additionally, the data store 122 of the client device 120 may include at least one user identifier 132.The user identifiers 132 may uniquely identify the user of the client device 120.In one embodiment, the user identifiers 132 may include a username, a password, and/or biometric data related to facial recognition, retina recognition, fingerprint recognition, and the like.", "Similarly, the data store 122 of the client device 120 may include at least one device identifier 135.The device identifiers 132 may uniquely identify the client device 120.In one embodiment, the device identifiers 135 may be a unique hardware identifier such as a GUID (Globally Unique Identifier), UUID (Universally Unique Identifier), UDID (Unique Device Identifier), serial number, IMEI (Internationally Mobile Equipment Identity), Wi-Fi MAC (Media Access Control) address, Bluetooth MAC address, a CPU ID, and/or the like, or any combination of two or more such hardware identifiers.", "In another embodiment, the device identifier 135 may be a unique software identifier such a token or certificate, based at least in part on the aforementioned unique hardware identifiers.", "The client device 120 may be configured to execute various applications.", "For example, the client device 120 may be configured to execute applications such as secure container applications, web browsing applications, email applications, instant messaging applications, word processing applications and/or other applications capable of receiving and/or rendering resources 165 on a display 136 associated with the client device 120.Any application capable of receiving and/or rendering resources 165 on a display 136 of the client device 120 is generally referred to herein as a “client side application” 126.The client side application 126 may be stored in the memory of the client device 120.In one embodiment, the client side application 126 may be a secure container application that may be authorized to receive and render resources 165 in accordance with at least one resource rule 171, as described herein.", "The client side application 126 may include a cryptographic key to decrypt email resources 165 ted with a cryptographic key in order to prevent unauthorized access to the email resources 165.For instance, the client side application 126 may have a cryptographic key that may be capable of decrypting email resources 165 transmitted in an encrypted format to the client device 120 by an access control service 174 executed by an access control server 150.The client side application 126 may be executed to transmit at least one request 177 to access at least one email resource 165.In certain embodiments, the client side application 126 may transmit requests 177 to an access control service 174.In some embodiments, the requests 177 may include a listing of specific email resources 165 the client device 120 seeks to access.", "In other embodiments, the requests 177 may include an indication that the client device 120 seeks access to email resources 165 associated with the client device 120, such as email resources 165 addressed to the user of the client device 120.In any instance, the requests 177 may include data from the data store 122 of the client device 120 that may assist an access control service 174 in determining whether the client device 120 is authorized to access the email resources 165.In one embodiment, the request 177 may include the device profile 123 associated with the client device 120.In another embodiment, the request 177 may include user identifiers 132 associated with the client device 120.In yet another embodiment, the request 177 may include device identifiers 135 associated with the client device 120.The client side application 126 may be further executed to receive an indication that the client device 120 is authorized to access the email resources 165.In certain embodiments, the client side application 126 may receive an authorization indication from an access control service 174 executed by an access control server 150.In some embodiments, the authorization indication may specify which, if any, email resources 165 that the client device 120 is authorized to access and may specify the manner in which the client device 120 may access such email resources 165.In one embodiment, the authorization indication may specify that the client device 120 is authorized to access the email resources 165 while the client device 120 is located within at least one authorized location.", "In another embodiment, the authorization indication may specify that the client device 120 is authorized to access the email resources 165 while the current time associated with the client device 120 is within at least one authorized window.", "In yet another embodiment, the authorization indication may specify that the client device 120 is authorized to access the email resources 165 while the client device 120 is communicatively connected to at least one network 110 and/or at least one network beacon associated with the networks 110, as described in application Ser.", "No.", "13/656,046 entitled “SYSTEMS AND METHODS FOR CONTROLLING NETWORK ACCESS,” which is incorporated herein by reference in the entirety.", "The client side application 126 may be further executed to receive at least one email resource 165.In certain embodiments, the client side application 126 may receive email resources 165 from an access control service 174 executed by an access control server 150.In some embodiments, the client side application 126 may receive email resources 165 from an enterprise email service, such as Microsoft Exchange, Lotus Notes, Novell Groupwise, Zimbra, or the like.", "In other embodiments, the client side application 126 may receive email resources 165 from a distribution service executed by a distribution server, as described in application Ser.", "Nos.", "13/396,356 and 13/623,627 both entitled “CONTROLLING DISTRIBUTION OF RESOURCES ON A NETWORK,” which are incorporated herein by reference in their entirety.", "In any instance, the email resources 165 may include various types of electronic data, such as email messages and email attachments.", "In certain embodiments, the email messages may include text and/or formatting in email headers, email sender fields, email recipient fields, email subject fields, email bodies, email signatures, and/or email footers.", "Additionally, the email attachments may include settings-type attachments, applications-type attachments, and content-type attachments.", "In one embodiment, settings-type attachments may include hardware settings, software settings, and/or the like that configure the functionality provided by the client device 120.In another embodiment, application-type attachments may include book applications, business applications, catalogue applications, education applications, entertainment applications, finance applications, food and drink applications, games applications, health and fitness applications, lifestyle applications, medical applications, music applications, navigation applications, news applications, newsstand applications, photo and video applications, productivity applications, reference applications, social networking applications, sports applications, travel applications, utility applications, weather applications, and/or the like.", "In yet another embodiment, content-type attachments may include application content, video content, image content, audio content, text content, word processor content, presentation content, spreadsheet content, database content, compressed folder content, disk image content, encoded content, backup content, web content, page layout content, plug-in content, font content, system content, developer content, data content and/or the like.", "The client side application 126 may be similarly executed to receive at least one resource rule 171 associated with the email resources 165.In certain embodiments, the resource rules 171 may regulate user of and/or access to the email resources 165.In some embodiments, the resource rules 171 may include format rules, content rules, attachment rules, and/or access rules.", "In one embodiment, the format-type resource rules 171 may specify at least one of required, permitted, and/or prohibited formats of the email resources 165.For example, a format-type resource rule 171 may specify that all email resources 165 must be encoded with AES-256 bit encryption.", "In another embodiment, the content-type resource rules 171 may specify at least one of required, permitted, and/or prohibited content of the email resources 165.For instance, a content-type resource rule 171 may specify that any email resources 165 containing the text “confidential” must be transmitted utilizing a secure transmission protocol, such as the HTTPS/SSL transmission protocol.", "In yet another embodiment, the attachment-type resource rules 171 may specify at least one of required, permitted, and/or prohibited attachments to the email resources 165.For example, an attachment-type resource rule 171 may specify that attachments to the email resources 165 must be stripped from the email resources 165.In yet a further embodiment, the access-type resource rules 171 may specify at least one of required, permitted, and/or prohibited access to the email resources 165.For instance, an access-type resource rule 171 may specify that the email resources 165 must be configured to be exclusively accessible via a secure container application, such as the client side application 126.Furthermore, the various types of resource rules 171 may be combined to establish granular access rights.", "For example, a combination of resource rules 171 may specify required file formats, encryption protocols, body and/or attachment components, and authorized applications associated with the email resources 165.In some embodiments, the resource rules 171 may be metadata and/or other indications that describe the email resources 165.In particular, the resources rules 171 may specify categories/sub-categories to which the email resources 165 belong, that the email resources 165 are considered favorites, the ownership of the email resources 165, the managing party of the email resources 165, that the email resources 165 are confidential, that the email resources 165 are password protected, the historical version of the email resources 165, at least one description of the email resources 165, at least one comment regarding the email resources 165, the size and format of the email resources 165, the download priority associated with the email resources 165, an expiration date associated with the email resources 165, at least one effective date associated with the email resources 165, and/or the like.", "In other embodiments, the resource rules 171 associated with the email resources 165 may change based on the state of the client device 120.In certain embodiments, the stringency of the resource rules 171 may be increased, reduced, and/or eliminated based on the state of the client device 120.In one embodiment, the stringency of the resource rules 171 may be increased, reduced, and/or eliminated if the client device 120 is located within the transmission range of certain network beacons and/or certain networks 110 associated with such network beacons.", "In another embodiment, the stringency of the resource rules 171 may be increased, reduced, and/or eliminated if the client device 120 is located within at least one location.", "In yet another embodiment, the stringency of the resource rules 171 may be increased, reduced, and/or eliminated if the current time associated with the client device 120 is within at least one time window.", "In yet a further embodiment, the stringency of the resource rules 171 may be increased, reduced, and/or eliminated if the client device 120 has previously satisfied the resource rules 171.Additionally, the client side application 126 may be executed to determine whether the client device 120 is authorized to access the email resources 165.In certain embodiments, the client side application 126 may determine whether the resource rules 171 associated with the email resources 165 are satisfied by the email resources 165.For instance, the client side application 126 may determine that the client device 120 is authorized to access the email resources 165 if the email resources 165 are configured to be inaccessible via certain unauthorized applications and are configured to be accessible via certain authorized applications, as may be specified by an administrator associated with the email resources 165.In some embodiments, the client side application 126 may determine whether the client device is authorized based at least in part on at least one of the device profile 123, user identifiers 132, or device identifiers 135.The client side application 126 may be further executed to modify the email resources 165.In certain embodiments, the client side application 126 may modify the email resources 165 in response to a determination that the email resources 165 do not satisfy the resource rules 171 associated with the email resources 165.In particular, the client side application 126 may modify the email resources 165 so that the email resources 165 satisfy the resource rules 171 associated with the email resources 165, such as by configuring the email resources 165 to be inaccessible via certain unauthorized applications.", "In some embodiments, the client side application 126 may modify at least one portion of the email resources 165.In other embodiments, the client side application 126 may modify all portions of and/or the entirety of the email resources 165.In any instance, the client side application 126 may modify the email resources 165 by formatting, encoding, encrypting, configuring, adding, removing, stripping, moving, replacing and/or flagging portions of the email resources 165.In one embodiment, the client side application 126 may modify the email resources 165 by formatting the email resources 165 into HyperText Markup Language (HTML), Rich Text, Plain Text, and/or other formats.", "In another embodiment, the client side application 126 may modify the email resources 165 by encoding the email resources 165 using Advanced Encryption Standard (AES), Data Encryption Standard (DES), and/or other encryption protocols.", "In yet another embodiment, the client side application 126 may modify the email resources 165 by configuring the email resources 165 to be exclusively accessible via at least one secure container application, such as the client side application 126.In yet a further embodiment, the client side application 126 may modify the email resources 165 by adding portions to and/or or removing portions from the email resources 165, for instance, by adding or removing an email signature.", "Additionally, in an exemplary embodiment, the client side application 126 may modify the email resources 165 by removing portions of the email resources 165 and configuring the removed portions of the email resources 165 to be exclusively accessible via a secure container application, such as the client side application 126.For example, the client side application 126 may remove attachments from the email resources 165 and may encrypt the removed attachments based at least in part on at least one cryptographic key accessible to the client side application 126.Additionally, the client side application 126 may encrypt the email resources 165 as a whole, thereby preventing the email resources 165 from being accessible via certain unauthorized applications on the client device 120 that an administrator has identified as problematic and/or insecure, while providing access to the email resources 165 via certain authorized applications.", "In another embodiment, the client side application 126 may modify the email resources 165 by performing at least one of decrypting the email resources 165, re-encrypting the email resources 165, digitally signing email resources 165, or digitally re-signing email resources 165.In yet another embodiment, the client side application 126 may modify the email resources 165 by moving certain portions of the email resources 165, such as by moving a photograph from the body of the email resources 165 to the attachments of the email resources 165.In yet a further embodiment, the client side application 126 may modify the email resources 165 by replacing certain portions of the email resources 165, such as replacing misspelled text with the properly spelled text.", "In even yet a further embodiment, the client side application 126 may modify the email resources 165 by flagging the email resources 165 as having been modified, such as by attaching an indication to the email resources 165 that provides information related to the modification of the email resources 165.The client side application 126 may be yet further executed to access at least one email resource 165.In certain embodiments, the client side application 126 may access the email resources 165 received from an access control service 174 and/or another distribution service.", "In some embodiments, the client side application 126 may access the email resources 165 on the client device 120 in accordance with the resource rules 171.For example, the client side application 126 may determine that the email resources 165 may not be accessed by the client device 120 because the client device 120 is not located within an authorized location specified by the resource rules 171 associated with the email resources 165.In any instance, the client side application 126 may access the email resources 165 on the client device 120 by storing, installing, activating, decrypting, confirming digital signatures, rendering and/or executing the email resources 165 on the client device 120.In one embodiment, the client side application 126 may store the email resources 165 on the client device 120 by placing the email resources 165 in the data store 122 of the client device 120.In another embodiment, the client side application 126 may install the email resources 165 on the client device 120 by placing the email resources 165 in the data store 122 of the client device 120 and by disabling and/or removing any files that conflict with the email resources 165.In yet another embodiment, the client side application 126 may activate the email resources 165 on the client device 120 by placing the email resources 165 in the data store 122 of the client device 120, by disabling and/or removing any files that conflict with the email resources 165, and by instructing the client device 120 to conform its operations to the email resources 165.In yet a further embodiment, the client side application 126 may decrypt the email resources 165 and/or confirm the digital signature of the email resources 165 to provide the client device 120 with access to the email resources 165.Additionally, the client side application 126 may call on other applications and/or services available to the client device 120, which may be associated with the email resources 165.In yet a further embodiment, the client side application 126 may render the email resources 165 on the client device 120 by presenting the email resources 165 in a user interface 137 executed on the display 136 of the client device 120.In particular, the client side application 126 may render the email resources 165 in a user interface 137 by decompressing compressed files and presenting the uncompressed files, decrypting encrypted files and presenting the decrypted files, confirming the digital signature of files and presenting the confirmed files, mounting disk image files and presenting the mounted image files, running executable files and presenting the executed files, by enabling a data search of the email resources 165 and presenting the featured output in a user interface 137, by calling on another application on the client device 120 to respond to data links contained within the email resources 165, and/or by transmitting a part or the whole of the email resources 165 to another application on the client device 120.The client side application 126 may render a single email resource 165 or a series of email resources 165 in a comprehensive manner, such as presenting image files in a slideshow-style presentation, and may further render an environment that displays an array of email resources 165 in a single view, such as a category-based tree or outline format.", "Additionally, in an exemplary embodiment, the client side application 126 may execute the email resources 165 by placing the email resources 165 in the data store 122 of the client device 120, by disabling and/or removing any files that conflict with the email resources 165, and by instructing the client device 120 to perform the operations of the email resources 165.In certain embodiments, the client side application 126 may be a secure container application that is configured to protect the email resources 165 from unauthorized access.", "In some embodiments, the client side application 126 may be configured to protect email resources 165 that have been received from an access control service 174.In one embodiment, the client side application 126 may be executed to enforce the resource rules 171 and/or other metadata associated with the email resources 165.For instance, the client side application 126 may prohibit cutting, copying, pasting, transmitting, emailing, text messaging, screen capturing, and/or otherwise manipulating the email resources 165 while the email resources 165 are accessed by the client side application 126.In another embodiment, the client side application 126 may prohibit other applications on the client device 120 and/or other services accessible to the client device 120 from accessing the email resources 165.In particular, the client side application 126 may monitor the data stream between the network 110 and the client device 120, may block any access attempts by another application and/or service, may proxy the email resources 165, and may present the proxyied email resources 165 in a user interface 137 rendered by the client side application 126.The access control server 150 may comprise, for example, a server computer or any other system providing access control capability.", "Alternatively, a plurality of access control servers 150 may be employed that are arranged, for example, in at least one server bank or computer bank or other arrangements.", "For example, a plurality of access control servers 150 together may comprise a cloud computing resource, a grid computing resource, and/or any other distributed computing arrangement.", "Such access control servers 150 may be located in a single installation or may be distributed among many different geographic locations.", "For purposes of convenience, the access control server 150 is referred to herein in the singular.", "Even though the access control server 150 is referred to in the singular, it is understood that a plurality of access control servers 150 may be employed in the arrangements as descried herein.", "The access control server 150 may comprise a memory for storing data and applications and a processor for executing applications stored in memory, as will be described with respect to FIG.", "12.The memory of the access control server 150 may comprise a data store 153.The data store 153 may be representative of at least one data store.", "The data store 153 may contain certain data that is accessible to the access control server 150.In particular, the data store 153 may contain at least one email resource 165 and at least one resource rule 171 associated with the email resources 165, as described herein.", "The data in the data store 153 may be associated with the operation of certain applications and/or functionalities executed by the access control server 150.The data store 153 may utilize strong encryption standards to protect the email resources 165 from unauthorized access.", "For example, the data store 153 may utilize AES (Advanced Encryption Standard) or a similar strong encryption standard commonly utilized for server-side data storage.", "The access control server 150 may execute certain applications and/or functionalities such the access control service 174, as well as other applications, services, processes, systems, engines, or functionality not disclosed in detail herein.", "The access control service 174 may be executed to control email access.", "In particular, the access control service 174 may limit access to at least one email resource 165 to at least one client device 120 that is authorized to access the email resources 165.The access control service 174 may be further executed to modify at least one email resource 165 so that the email resources 165 satisfy at least one resource rule 171 associated with the email resources 165.The access control service 174 may yet be further executed to distribute at least one email resource 165 to at least one client device 120 that is authorized to access the email resources 165.The access control service 174 may be executed to control access to at least one email resource 165.In certain embodiments, the access control service 174 may be executed to determine whether at least one client device 120 is authorized to access the email resources 165.In some embodiments, the client side application 126 may determine whether the resource rules 171 associated with the email resources 165 are satisfied by the email resources 165.For instance, the access control service 174 may determine that a client device 120 is authorized to access the email resources 165 if the attachments to the email resources 165 have been stripped from the email resources 165 in accordance with the resource rules 171, which specify that the email resources 165 may not have attachments.", "In other embodiments, the access control service 174 may determine whether the client device is authorized based at least in part on at least one of the device profile 123, user identifiers 132, or device identifiers 135.The access control service 174 may be further executed to modify the email resources 165 to satisfy the resource rules 171 associated with the email resources 165.In certain embodiments, the access control service 174 may modify the email resources 165 in response to a determination that the email resources 165 do not satisfy the resource rules 171 associated with the email resources 165.In particular, the access control service 174 may modify the email resources 165 so that the email resources 165 satisfy the resource rules 171 associated with the email resources 165.In some embodiments, the access control service 174 may modify at least one portion of the email resources 165.In other embodiments, the access control service 174 may modify all portions of and/or the entirety of the email resources 165.In any instance, the access control service 174 may modify the email resources 165 by formatting, encoding, configuring, adding, removing, stripping, moving, replacing or flagging portions of the email resources.", "In one embodiment, the access control service 174 may modify the email resources 165 by formatting the email resources 165 into HyperText Markup Language (HTML), Rich Text, Plain Text, and/or other formats.", "In another embodiment, the access control service 174 may modify the email resources 165 by encoding the email resources 165 using Advanced Encryption Standard (AES), Data Encryption Standard (DES), and/or other encryption protocols.", "In yet another embodiment, the access control service 174 may modify the email resources 165 by configuring the email resources 165 to be exclusively accessible via at least one secure container application, such as a client side application 126.In yet a further embodiment, the access control service 174 may modify the email resources 165 by adding portions to and/or or removing portions from the email resources 165, for instance, by adding or removing an email signature.", "Additionally, in an exemplary embodiment, the access control service 174 may modify the email resources 165 by removing portions from the email resources 165 and configuring the removed portions of the email resources 165 to be exclusively accessible via a secure container application, such as the client side application 126.For example, the access control service 174 may remove attachments to the email resources 165 from the email resources 165, may encode the removed attachments based at least in part on at least one cryptographic key, and may make the removed attachments and cryptographic keys accessible to the client side application 126.In another embodiment, the access control service 174 may modify the email resources 165 by performing at least one of decrypting the email resources 165, re-encrypting the email resources 165, cryptographically signing email resources 165, or re-signing email resources 165.In yet another embodiment, the access control service 174 may modify the email resources 165 by moving certain portions the email resources 165, such as by moving a photograph from the body of the email resources 165 to the attachments of the email resources 165.In yet a further embodiment, the access control service 174 may modify the email resources 165 by replacing certain portions of the email resources 165, such as replacing misspelled text with the properly spelled text.", "In even yet a further embodiment, the access control service 174 may modify the email resources 165 by flagging the email resources 165 as having been modified, such as attaching an indication to the email resources 165 that provides information related to the modification of the email resources 165.The access control service 174 may be yet further executed to transmit at least one email resource 165 to at least one client device 120.In certain embodiments, the access control service 174 may transmit the email resources 165 to the client devices 120 responsive to a determination that the client devices 120 are authorized to access the email resources 165.In some embodiments, the access control service 174 may transmit the email resources 165 to the client devices 120 responsive to modifying the email resources 165 to satisfy the resource rules 171 associated with the email resources 165.In one embodiment, the access control service 174 may directly transmit the email resources 165 to a client side application 126 executed by the client devices 120.In another embodiment, the distribution service 174 may make the email resources 165 available for download by the client devices 120 and may transmit the email resources 165 to the client devices 120 upon receiving requests 177 to download the email resources 165 from the client devices 120.In any instance, the access control service 174 may establish a communicative connection with the client devices 120 by utilizing a secure transmission protocol, such as HTTPS/SSL, before transmitting the email resources 165 to the client devices 120.FIG.", "2 is a flowchart illustrating exemplary functionality performed by an access control service 174 executed by an access control server (FIG.", "1) according to certain embodiments.", "It is understood that the flowchart of FIG.", "2 provides merely an example of the many different types of functional arrangements that may be employed to implement the operation of the access control service 174 as described herein.", "As an alternative, the flowchart of FIG.", "2 may be viewed as depicting an example of steps of a method implemented in the access control server 150 according to at least one embodiment.", "Beginning with step 203, the access control service 174 may identify at least one email resource 165.In certain embodiments, the access control service 174 may identify at least one email resource 165 associated with at least one client device 120.In one embodiment, the email resources 165 may be associated with the client devices 120 if the email resources 165 are addressed to the client devices 120 and/or the users of the client devices 120.For instance, the email resources 165 may be addressed to the client devices 120 and/or the users of the client devices 120 if the identities of the client devices 120 and/or the users of the client devices 120 are specified within the email headers, email sender fields, email CC fields, email BCC fields, email recipient fields, email subject fields, email bodies, email signatures, and/or email footers of the email resources 165.In another embodiment, the email resources 165 may be associated with the client devices 120 if the email resources 165 are accessible to the client devices 120, for instance, via at least one user identifier, at least one device identifier, and/or at least one device profile associated with the client devices 120.In yet another embodiment, the email resources 165 may be associated with the client devices 120 according to a listing of associated email resources 165 and client devices 120.In any instance, the email resources 165 may include email messages, email attachments, and/or other electronic data, as described herein.", "Next, in step 206, the access control service 174 may identify at least one resource rule 171.In certain embodiments, the access control service 174 may identify at least one resource rule 171 associated with at least one email resource 165.In some embodiments, a given resource rule 171 may be associated with at least one email resource 165 and, similarly, a given email resource 165 may be associated with at least one resource rule 171.In one embodiment, the resource rules 171 may be associated with the email resources 165 if the resource rules 171 are embedded within the email headers, email bodies, email signatures, and/or email footers of the email resources 165.In particular, the email resources 165 may include embedded metadata and/or other instructions that represent at least one resource rule 171.In another embodiment, the resource rules 171 may be associated with the email resources 165 if the resource rules 171 are affixed to the email resources 165, such as attachments to the email resources 165.In yet another embodiment, the resource rules 171 may be associated with the email resources 165 according to a listing of associated email resources 165 and resource rules 171.In any instance, the resource rules 171 may regulate access to the email resources 165 associated with the resource rules 171 by the client devices 120 associated with the email resources 165, as described herein.", "Then, in step 209, the access control service 174 may determine whether the email resources 165 satisfy the resource rules 171 associated with the email resources 165.In certain embodiments, the access control service 174 may determine that the client devices 120 associated with the email resources 165 are authorized to access the email resources 165 if the email resources 165 satisfy the associated resources rules 171.In any instance, the access control service 174 may determine whether the state of the email resources 165 satisfies the requirements specified by the associated resource rules 171.In particular, the access control service 174 may determine whether the email headers, email sender fields, email CC fields, email BCC fields, email recipient fields, email subject fields, email bodies, email signatures, email footers, and/or email attachments of the email resources 165 satisfy the associated resource rules 171, as described herein.", "If the access control service 174 determines that the email resources 165 do not satisfy the resource rules 171, then the access control service 174 may proceed to step 212 and may modify the email resources 165.In certain embodiments, the access control service 174 may modify the email resources 165 so that the email resources 165 satisfy the resource rules 171 associated with the email resources 165.In some embodiments, the access control service 174 may modify at least one portion of the email resources 165.In other embodiments, the access control service 174 may modify all portions of and/or the entirety of the email resources 165.In any instance, the access control service 174 may modify the email resources 165 by formatting, encoding, configuring, adding, removing, stripping, moving, replacing and/or flagging portions of the email resources 165, as described herein.", "On the contrary, if the access control service 174 determines that the email resources 165 satisfy the resource rules 171, then the access control service 174 may proceed to step 215 and may authorize the client devices 120 to access the email resources 165.In certain embodiments, the access control service 174 may authorize the client devices 120 to access the email resources 165 by transmitting the email resources 165 to at least one client side application 126 executed by the client devices 120.In some embodiments, the access control service 174 may authorize the client devices 120 to access the email resources 165 by notifying the client devices 120 that the email resources 165 may be downloaded from the access control service 174 and may further transmit the email resources 165 to the client devices 120 upon a request 177.In any instance, the access control service 174 may authorize the client devices 120 to access the email resources 165 by providing the client devices 120 with a means of accessing the email resources 165.In one embodiment, the access control service 174 may authorize the client devices 120 to access at least one unmodified email resource 165.In another embodiment, the access control service 174 may authorize the client devices 120 to access at least one email resource 165 that has been modified by the access control service 174 so that the email resources 165 satisfy the resource rules 171 associated with the email resources 165.FIG.", "3 is a flowchart illustrating exemplary functionality performed by a client side application 126 executed by a client device 120 (FIG.", "1) according to certain embodiments.", "It is understood that the flowchart of FIG.", "3 provides merely an example of the many different types of functional arrangements that may be employed to implement the operation of the client side application 126 as described herein.", "As an alternative, the flowchart of FIG.", "3 may be viewed as depicting an example of steps of a method implemented in the client device 120 according to at least one embodiment.", "Beginning with step 303, the client side application 126 may transmit at least one request 177 to access at least one email resource 165.In certain embodiments, the client side application 126 may transmit requests 177 to an access control service 174.In some embodiments, the requests 177 may include a listing of specific email resources 165 that the client device 120 seeks to access.", "In other embodiments, the requests 177 may include an indication that the client device 120 seeks access to email resources 165 associated with the client device 120, such as email resources 165 addressed to the user of the client device 120.In any instance, the requests 177 may include data from the data store 122 of the client device 120, such as device profiles 123, user identifiers 132, and device identifiers 135 associated with the client device 120, as described herein.", "Next, in step 306, the client side application 126 may receive at least one email resource 165.In certain embodiments, the client side application 126 may receive at least one email resource 165 from an access control service 174 executed by an access control server 150.In one embodiment, the client side application 126 may directly receive the email resources 165 from the access control service 174.In another embodiment, the client side application 126 may receive at least one indication from the access control service 174 that specify that the email resources 165 are available for download from the access control service 174.In such embodiment, the client side application 126 may request to download the email resources 165 from the access control service 174 in response to receiving an indication that the email resources 165 are available for download from the access control service 174.In some embodiments, the client side application 126 may receive at least one email resource 165 from an enterprise email service, such as Microsoft Exchange or Lotus Notes, or from a distribution service executed by a distribution server, as described herein.", "Then, in step 309, the client side application 126 may identify at least one resource rule 171.In certain embodiments, the client side application 126 may identify at least one resource rule 171 associated with at least one email resource 165.In some embodiments, the resource rules 171 may be associated with multiple email resources 165 and the email resources 165 may be associated with multiple resource rules 171, as described herein.", "In one embodiment, the resource rules 171 may be associated with the email resources 165 if the resource rules 171 are embedded within the email headers, email bodies, email signatures, and/or email footers of the email resources 165.In particular, the email resources 165 may include embedded metadata and/or other instructions that represent at least one resource rule 171.In another embodiment, the resource rules 171 may be associated with the email resources 165 if the resource rules 171 are affixed to the email resources 165, such as attachments to the email resources 165.In yet another embodiment, the resource rules 171 may be associated with the email resources 165 according to a listing of associated email resources 165 and resource rules 171.In any instance, the resource rules 171 may regulate access to the email resources 165 associated with the resource rules 171 by the client devices 120 associated with the email resources 165, as described herein.", "Next, in step 312, the client side application 126 may determine whether the email resources 165 satisfy the resource rules 171 associated with the email resources 165.In certain embodiments, the client side application 126 may determine that the client device 120 associated with the email resources 165 is authorized to access the email resources 165 if the email resources 165 satisfy the associated resources rules 171.In any instance, the client side application 126 may determine whether the state of the email resources 165 satisfies the requirements specified by the associated resource rules 171.In particular, the client side application 126 may determine whether the email headers, email sender fields, email CC fields, email BCC fields, email recipient fields, email subject fields, email bodies, email signatures, email footers, and/or email attachments of the email resources 165 satisfy the associated resource rules 171, as described herein.", "If the client side application 126 determines that the email resources 165 do not satisfy the resource rules 171, then the client side application 126 may proceed to step 315 and may modify the email resources 165.In certain embodiments, the client side application 126 may modify the email resources 165 so that the email resources 165 satisfy the resource rules 171 associated with the email resources 165.In some embodiments, the client side application 126 may modify at least one portion of the email resources 165.In other embodiments, the access control service 174 may modify all portions of and/or the entirety of the email resources 165.In any instance, the client side application 126 may modify the email resources 165 by formatting, encoding, configuring, adding, removing, stripping, moving, replacing and/or flagging portions of the email resources 165, as described herein.", "On the contrary, if the client side application 126 determines that the email resources 165 satisfy the resource rules 171, then the client side application 126 may proceed to step 318 and may authorize the client device 120 to access the email resources 165.In certain embodiments, the client side application 126 may authorize the client device 120 to access the email resources 165 by providing the client devices 120 with a means of accessing the email resources 165.For example, the client side application 126 may enable storing, installing, activating, rendering and/or executing the email resources 165 on the client device 120, as described herein.", "In one embodiment, the client side application 126 may authorize the client device 120 to access at least one unmodified email resource 165.In another embodiment, the client side application 126 may authorize the client device 120 to access at least one email resource 165 that has been modified by the access control service 174 so that the email resources 165 satisfy the resource rules 171 associated with the email resources 165.In yet another embodiment, the client side application 126 may authorize the client device 120 to access at least one email resource 165 that has been modified by the client side application 126 so that the email resources 165 satisfy the resource rules 171 associated with the email resources 165.FIG.", "4 is an example of a user interface 137a that allows an administrator of an access control service 174 (FIG.", "1) to associate at least one resource rule 171 (FIG.", "1) with at least one email resource 165 (FIG.", "1).", "In certain embodiments, the user interface 137a may include a grouping view field 402, a rules view field 404, an add rules button 406, at least one rules description field 408, at least one action button 410, and at least one defined rule 412.The grouping view field 402 may allow the administrator to select a group of client devices 120 and/or a group of users of client devices 120 to manage.", "For example, the administrator may manipulate the resource rules 171 that apply to the “Enterprise” group of client devices 120 by selecting the “Enterprise” grouping from the pull-down provided by the grouping view field 402.The rules view field 404 may allow the administrator to filter the resource rules 171 to manage.", "For instance, the administrator may filter the resource rules 171 by either selecting the “All Email Rules” set of resource rules 171 or the “Active Email Rules” set of resource rules 171 from the options provided by the rules view field 404.The add rules button 406 may allow the administrator to add new resource rules 171 to the collection of resource rules 171 that apply to the “Enterprise” group of client devices 120.For example, invoking the add rules button 406 may instruct the access control service 174 to provide another user interface 137 in which the administrator may define at least one new resource rule 171, as will be described in FIG.", "5.The rules description fields 408 may specify at least one characteristic that describes each of the resource rules 171.For instance, the rules description fields 408 may include indications of whether a rule is active 408a, a name of a rule 408b, a storage location of a rule 408c, a brief description of a rule 408d, an assignment of a rule 408e, an effective date and/or expiration date of a rule 408f, and a last modified date of a rule 408g.", "The action buttons 410 may allow an administrator to take at least one action to a resource rule 171, such as editing the resource rule 171 and/or adjusting the settings of a resource rule 171.The defined rules 412 may include at least one resource rule 171 that has been previously created by an administrator of the access control service 174, such as the “Encrypt Email Attachments” rule 412a and the “Remove Email Attachments” rule 412b.", "FIG.", "5 is an example of a user interface 137b that allows an administrator of an access control service 174 (FIG.", "1) to create at least one new resource rule 171 (FIG.", "1), which may provide and/or control access to at least one application and/or service accessible to at least one client device 120 (FIG.", "1).", "In certain embodiments, the user interface 137b may include a rule type field 502, an access credentials field 504, an access rights field 506, and at least one action button 508.In some embodiments, the access rights field 506 may include an “Encrypt All Attachments” button 506a and a “Remove All Attachments” button 506b.", "The rule type field 502 may include one of more types of resource rules 171 that may be created through the user interface 137b.", "For example, an administrator of the access control service 174 may select “Exchange ActiveSync” from the rules type field 502 to create resource rules 171 associated with email resources 165 (FIG.", "1).", "The access credentials field 504 may include at least one field that accepts input of at least one credential for access to at least one application and/or service accessible to the client devices 120.For instance, an administrator of the access control service 174 may input the “Domain,” “Username,” “Email Address,” “Password,” and “Payload Certificates” associated with the client devices 120.The access rights field 506 may include at least one access right that may be defined for the client devices 120, which may control access by client devices 120 to applications and/or services.", "For example, an administrator of the access control service 174 may apply at least one access restriction including “Prevent Moving Messages,” “Prevent Use in 3rd Party Apps,” “Disable recent contact sync,” “Encrypt All Attachments” 506a, and “Remove All Attachments” 506b.", "The action buttons 508 may include at least one button that saves and/or deletes the resource rules 171 defined in the user interface 137b.", "For example, an administrator of the access control service 174 may invoke the “Save” action button 508 to store the resource rules 171 associated with the email resources 165 in the data store 153 (FIG.", "1) of the access control server 150 (FIG.", "1).", "FIG.", "6 is an example of a user interface 137c executed by a client side application 126 (FIG.", "1) on a client device 120 (FIG.", "1).", "In certain embodiments, the client side application 126 may be an application native to the client device 120 that is capable of receiving and/or rendering email resources 165.For example, the client side application 126 may be a native email application, such as Microsoft Outlook or Apple Mail.", "The client side application 126 may include an email selection field 602 and an email viewing pane 604.The email selection field 602 may include at least one email message that may be selected to access within the email viewing pane 604.For example, the user of the client device, such as “John Smith,” may select an email message entitled “Confidential—Q3 2012 Revenue” sent to “John Smith” from “George Williams.” The email viewing pane 604 may include a sender field, a recipient field, a title field, a body field, and at least one attachment 606.For instance, the email viewing pane 604 may provide a user of a client device 120 to access the attachment entitled “PROTECTED: Q3 2012 Revenue.pdf.” FIG.", "7 is an example of a user interface 137d executed by a client side application 126 (FIG.", "1) on a client device 120 (FIG.", "1).", "In certain embodiments, the client side application 126 may be an application native to the client device 120 that is capable of receiving and/or rendering email resources 165.For example, the client side application 126 may be a native email application, such as Microsoft Outlook or Apple Mail, as similarly described in FIG.", "6.In some embodiments, the user of the client device 120 may request to access the attachment entitled “PROTECTED: Q3 2012 Revenue.pdf” by selecting the attachment on the user interface 137d.", "In one embodiment, the attachment entitled “PROTECTED: Q3 2012 Revenue.pdf” may be associated with resource rules 171 (FIG.", "1) that specify that the email resources 165 may only be accessed via a secure container application.", "The user interface 137d may provide an access selection field 702 to provide the user of the client device 120 with at least one access application and/or service that is available for accessing the email resources 165 in accordance with the associated resource rules 171.For example, the access selection field 702 may specify that a client side application 126 with secure container capabilities may be selected, a client side application 126 with native email capabilities may not be selected, and a printing function of the client device 120 may not be selected.", "By selecting the client side application 126 with secure container capabilities from the access selection field 702, the current client side application 126 with native email capabilities may call on the client side application 126 with secure container capabilities in order to access the email attachment.", "FIG.", "8 is an example of a user interface 137e executed by a client side application 126 (FIG.", "1) on a client device 120 (FIG.", "1).", "In certain embodiments, the client side application 126 may be a secure container application that is capable of receiving and/or rendering email resources 165, as described herein.", "In some embodiments, the user interface 137e may provide an authentication form which must be filled out by the user of the client device 120 in order to gain access to at least one email resource 165 accessible through the secure container environment of the client side application 126.In particular, the user interface 137e may provide an authentication form that includes a username field 802, a password field 804, and a login button 806.A user of the client device 120, such as “John Smith,” may provide a username, such as “John Smith,” in the username field 802, may provide a password, such as “ .", ".", ".", ",” and may invoke the login button 806 to provide the access credentials to the client side application 126.Responsive to a determination that the access credentials provided by the user of the client device 120 are authorized, the client side application 126 may provide the user of the client device 120 with access to the secure container environment of the client side application 126.FIG.", "9 is an example of a user interface 137f executed by a client side application 126 (FIG.", "1) on a client device 120 (FIG.", "1).", "In certain embodiments, the client side application 126 may be a secure container application that is capable of receiving and/or rendering email resources 165, as described herein.", "The secure container environment of the client side application 126 may include a views pane 902, a categories pane 904, and action buttons 906.The views pane 902 may include at least one view that is accessible to the user of the client device 120, such as an “all content” view, a “new content” view, a “recent activity” view, and a “favorites” view.", "The user of the client device 120 may select one of the available views, each of which may include a subset of email resources 165 related to the certain view.", "The categories pane 904 may include at least one category of email resources 165 that is available to the user of the client device 120, such as an “Email Attachments” category that is a subset of an “Email Resources” category.", "The user of the client device 120 may, for instance, select the “Email Attachments” category to access at least one email attachment that is configured to be accessible via the secure container environment of the client side application 126.The action buttons 906 may include a “Content” button, a “Downloads” button, a “Search” button, an “Updates” button, and a “Settings” button that may launch other user interfaces 137 provided by the client side application 126 to enable additional views, applications, and/or services.", "FIG.", "10 is an example of a user interface 137e executed by a client side application 126 (FIG.", "1) on a client device 120 (FIG.", "1).", "In certain embodiments, the client side application 126 may be a secure container application that is capable of receiving and/or rendering email resources 165, as described herein.", "The secure container environment of the client side application 126 may include an accessible resource listing 1002 and an access notification 1004.The user of the client device 120 may select an email resource 165, such an as email attachment, from the accessible resource listing 1002.Responsive to the user of the client device 120 selecting the “Q3 2012 Revenue.pdf” email resource 165 from the accessible resource listing 1002, the client side application 126 may provide the user with access to the email resource 165 by unlocking the protected file.", "In particular, the email resource 165 may have been encrypted with a symmetric cryptographic key and/or an asymmetric cryptographic key by an access control service 174 (FIG.", "1) according to at least one resource rule 171 (FIG.", "1) associated with the email resource 165, as described herein.", "Consequently, the client side application 126 may decrypt the email resource 165 to enable access to the email resource 165 and may provide an access notification 1004 that specifies that the client side application 126 is “Unlocking (the) PROTECTED file” and to “Please Wait” to access the email resource 165 while the client side application 126 unlocks the email resource 165.FIG.", "11 is an example of a user interface 137e executed by a client side application 126 (FIG.", "1) on a client device 120 (FIG.", "1).", "In certain embodiments, the client side application 126 may be a secure container application that is capable of receiving and/or rendering email resources 165, as described herein.", "The client side application 126 may include a resource title pane 1102, a resource content pane 1104 and a resource page selection pane 1106.The resource title pane 1102 may specify the title of the email resources 165, such as “Q3 2012 Revenue.” The resource content pane 1104 may include the body of the email resources 165, such as the pages of the PDF file “Q3 2012 Revenue.” The resource page selection pane 1106 may include at least one page of the email resources 165.The user of the client device 120 may, for example, select a page from the resource page selection pane 1106.Responsive to the user of the client device 120 selecting a certain page from the resource page selection pane 1106, the client side application 126 may navigate to the selected page and present the content of the selected page in the resource content pane 1104.FIG.", "12 depicts certain illustrative components for a networked environment 1200 according to various embodiments.", "In certain embodiments, the networked environment 1200 may include at least one network 110, at least one client device 120, an access control service 174, and at least one email service 1202.The email services 1202 may be configured to provide the client devices 120 with access to at least one email resource 165 (FIG.", "1) associated with the email services 1202.As an example, the email services 1202 may be and/or include at least one enterprise email service, such as Microsoft Exchange, Lotus Notes, and/or other services capable of distributing email resources 165 to client devices 120.The access control service 174 may be configured to authorize the client devices 120 to access to the email services 1202, may control the manner in which the client devices 120 are authorized to access the email services 1202, and may provide the client devices 120 with access to the email services 1202.In one embodiment, the access control service 174 may be configured to proxy email resources 165 provided to the client devices 120 by the email services 1202.The access control service 174 may, for instance, filter all email resources 165 transmitted between the email services 1202 and the client devices 120.Alternatively, the access control service 174 may proxy email resources 165 in transit to the client devices 120 from the email services 1202.In another embodiment, the access control service 174 may be configured to provide a gateway for access to the email services 1202.The access control service 174 may, for instance, provide authorized client devices 120 with access to the email services 1202 and deny unauthorized client devices 120 from accessing the email services 1202.In any instance, the access control service 174 may be configured to determine whether the client devices 120 are authorized to access the email resources 165.The access control service 174 may, for example, receive at least one request 177 (FIG.", "1) to access the email services 1202 from the client devices 120.The access control service 174 may determine whether the client devices 120 associated with the requests 177 are authorized to access the email services 1202 based on, for instance, at least one device profile 123 (FIG.", "1), at least one user identifier 132 (FIG.", "1), at least one device identifier 135 (FIG.", "1) associated with the client device 120, which may be included in the requests 177.The access control service 174 may provide the client devices 120 with access to the email services 1202 in response to a determination that the client devices 120 are authorized to access the email services 1202.In one embodiment, the access control service 174 may establish a communicative connection between the email services 1202 and the client devices 120, which may facilitate the transmission of email resources 165 between the email services 1202 and the client devices 120.In another embodiment, the access control service 174 may establish a communicative connection between the access control service 174 and the client devices 120, which may facilitate the transmission of email resources 165 associated with the email service 1202 between the access control service 174 and the client devices 120.Additionally, the access control service 174 may be configured to control access to the email resources 165 by the client devices 120.The access control service 174 may determine which email resources 165 the client devices 120 are authorized to access.", "The access control service 174 may also modify the email resources 165 before providing the client devices 120 with access to the email resources 165.In certain embodiments, the access control service 174 may determine whether the email resources 165 are accessible via at least one unauthorized application on the client devices 120 and may modify the email resources 165 to be inaccessible via the unauthorized applications.", "In some embodiments, the access control service 174 may query a listing of unauthorized applications, may determine whether the email resources 165 are configured to be accessible via the listed unauthorized applications, and, if so, may modify the email resources 165 to be inaccessible via the listed unauthorized applications.", "In one embodiment, the access control service 174 may encrypt the email resources 165 based on at least one encryption key to prevent unauthorized applications on the client devices 120 from accessing the email resources 165.In particular, the email resources 165, once encrypted, may not be accessed by applications that do not have the requisite decryption key.", "Thus, the access control service 174 may encrypt the email resources 165 based on at least one cryptographic schema that is foreign to the unauthorized applications, preventing the unauthorized applications from decrypting the email resources 165, and thereby preventing the unauthorized applications from accessing the email resources 165.In another embodiment, the access control service 174 may modify the file format of the email resources 165 to prevent unauthorized applications on the client devices 120 from accessing the email resources 165.For example, the access control service 174 may determine which file formats are accessible by the unauthorized applications and change the file formats of the email resources 165 to file formats that are inaccessible by the unauthorized applications.", "Moreover, in certain embodiments, the access control service 174 may modify the email resources 165 to be accessible via certain authorized applications.", "In some embodiments, the access control service 174 may query a listing of authorized applications, may determine whether the email resources 165 are configured to be accessible via the listed authorized applications, and, if not, may modify the email resources 165 to be accessible via the listed authorized applications.", "In one embodiment, the access control service 174 may encrypt the email resources 165 based on at least one cryptographic key that is associated with the authorized applications.", "Additionally, the access control service 174 may transmit the cryptographic key for decryption to the authorized applications on the client devices 120 so that the authorized applications may decrypt and access the email resources 165.In another embodiment, the access control service 174 may modify the file format of the email resources 165 to permit authorized applications on the client devices 120 to access the email resources 165 while preventing unauthorized applications on the client devices 120 from accessing the email resources 165.For example, the access control service 174 may determine which file extensions are accessible by the authorized applications and which file extensions are inaccessible by the unauthorized applications to change the file extensions of the email resources 165 to the identified file extensions to restrict the applications on the client devices 120 that may access the email resources 165.Furthermore, the access control service 174 may be configured to provide the client devices 120 with access to the email services 1202 and/or the email resources 165 associated with the email services 1202.In one embodiment, the access control service 174 may be configured to transmit email resources 165 to the client devices 120.For example, the access control service 174 may establish a secure communicative connection with the client devices 120, such as HTTPS/SSL, through which the access control service 174 may transmit the email resources 165 associated with the email services 1202 to the client devices 120.In another embodiment, the access control service 174 may be further configured to transmit at least one cryptographic key to at least one client side application 126 on the client devices 120 to enable such client side applications 126 to access the email resources 165 by decrypting the email resources 165 with the transmitted cryptographic key.", "As an example of the aforementioned embodiments, the access control service 174 may proxy at least one email resource 165 from an email service to a client device 120.Upon receiving the email resource 165, the access control service 174 may determine whether an administrator of the access control service 174 has specified certain applications that are authorized to access the email resources 165 and certain applications that are not authorized to access the email resources 165.For instance, the administrator may specify that applications created in-house may access the email resources 165 and that applications created by out-of-house may not access the email resources 165.Based on the administrator's specifications, the access control service 174 may modify the email resources 165 to be accessible via the in-house applications and inaccessible via the out-of-house applications.", "In particular, the access control service 174 may modify the email resources 165 based on an encryption key and/or file format that is foreign to the out-of-house applications.", "Once the email resources 165 are modified, the access control service 174 may transmit the email resources 165 to the proper client device 120.The access control service 174 may also transmit instructions to the in-house applications on the client device 120, including an appropriate decryption key, to provide the in-house applications with access to the email resources 165.Consequently, the in-house applications on the client device 120 may access the email resources 165 by decrypting the email resources 165 with the key received from the access control service 174, while the out-of-house applications on the client device 120 cannot access the email resources 165 due to their inability to decrypt the email resources 165.FIG.", "13 is a flowchart illustrating exemplary functionality performed by an access control service 174 executed by an access control server 150 (FIG.", "1) according to certain embodiments.", "It is understood that the flowchart of FIG.", "13 provides merely an example of the many different types of functional arrangements that may be employed to implement the operation of the access control service 174 as described herein.", "As an alternative, the flowchart of FIG.", "13 may be viewed as depicting an example of steps of a method implemented in the access control server 150 according to at least one embodiment.", "Beginning with step 1302, the access control service 174 may proxy at least one email resource 165 (FIG.", "1) from at least one email service 1202 (FIG.", "12) to at least one client device 120 (FIG.", "1).", "In one embodiment, the access control service 174 may be configured to proxy all data transmitted between the email services 1202 and the client devices 120.For example, the access control service 174 may stand in front of the email services 1202, as shown in FIG.", "12, to intercept any email resources 165 being transmitted from the email services 1202 to client devices 120.The access control service 174 may further prohibit the email resources 165 from proceeding to the client devices 120 as transmitted by the email services 1202 according to at least one resource rule 171 (FIG.", "1), as described herein.", "In another embodiment, the access control service 174 may be configured to act as a gateway that controls access to the email services 1202.For instance, the access control service 174 may transmit instructions to the email services 1202 that specify that email resources 165 intended for the client devices 120 must be transmitted to the client devices 120 via the access control service 174.Next, in step 1304, the access control service 174 may determine whether the email resources 165 are accessible to the client devices 120 via at least one unauthorized application on the client devices 120.In certain embodiments, at least one resource rule 171 (FIG.", "1) may specify that the client devices 120 are not authorized to access the email resources 165 via certain unauthorized applications on the client devices 120.In some embodiments, the resource rules 171 may specify a listing of applications that are not authorized to access the email resources 165 on the client devices 120.In one embodiment, the access control service 174 may query the data store 153 (FIG.", "1) of the access control server 150 to determine whether any such resource rules 171 apply to the email resources 165.In another embodiment, the access control service 174 may query the email services 1202 to determine whether any such resource rules 171 apply to the email resources 165.In yet another embodiment, the access control service 174 may query the client devices 120 to determine whether any such resource rules 171 apply to the email resources 165.In any instance, the access control service 174 may analyze the state of the email resources 165 to determine whether the email resources 165 comply with the resource rules 171.In one embodiment, the access control service 174 may determine whether the email resources 165 are encrypted with at least one cryptographic key that is associated with the unauthorized applications.", "For example, the access control service 174 may determine whether the email resources 165 may be decrypted by the unauthorized applications.", "In another embodiment, the access control service 174 may determine whether the file format of the email resources 165 is associated with the unauthorized applications.", "For instance, the access control service 174 may determine whether the email resources 165 are formatted with a file extension that is readable by the unauthorized applications.", "If the access control service 174 determines that the email resources 165 are not accessible via the unauthorized applications, the access control service 174 may proceed to step 1306.In particular, if the access control service 174 determines that the email resources 165 in their present state are inaccessible via the unauthorized applications, then the access control service 174 may refrain from modifying the email resources 165.If, however, the access control service 174 determines that the email resources 165 may be accessible via the unauthorized applications, then the access control service 174 may proceed to step 1308 to prevent the email resources 165 from being accessible via the unauthorized applications on the client devices 120.In certain embodiments, the access control service 174 may modify the email resources 165 to prevent the email resources 165 from being accessible via the unauthorized applications.", "In some embodiments, the access control service 174 may encrypt the email resources 165 based on at least one cryptographic key to prevent the unauthorized applications from accessing the email resources 165.For example, the email resources 165 may be encrypted by the access control service 174 based at least in part on a cryptographic key that is foreign to the unauthorized applications, thereby preventing the unauthorized applications from decrypting and accessing the email resources 165.In one embodiment, the email resources 165 may be encrypted by the access control service 174 based at least in part on the advanced encryption standard (AES) cryptographic schema.", "In another embodiment, the email resources 165 may be encrypted by the access control service 174 based at least in part on the data encryption standard (AES) cryptographic schema.", "In any instance, the email resources 165 may be encrypted, and/or obfuscated, by the access control service 174 in a manner that prevents the unauthorized applications on the client devices 120 from presenting at least one user of the client devices 120 with a human-readable version of the email resources 165.In other embodiments, the access control service 174 may modify the file format of the email resources 165 to prevent the unauthorized applications from accessing the email resources 165.For instance, the format of the file extension of the email resources 165 may be changed by the access control service 174 to a format that is foreign to the unauthorized applications, thereby preventing the unauthorized applications from interpreting and accessing the email resources 165.Thus, if the unauthorized applications are incapable of reading files that are formatted with the “.pdf” file extension, the access control service 174 may change the format of email resources 165 to the “.pdf” file extension to prevent the unauthorized applications from interpreting and accessing the email resources 165.Additionally, the access control service 174 may determine whether the email resources 165 may be accessible on the client devices 120 via at least one authorized application on the client devices 120.In certain embodiments, at least one resource rule 171 may specify that the client devices 120 are authorized to access the email resources 165 via certain authorized applications on the client devices 120.In some embodiments, the resource rules 171 may specify a listing of applications that are authorized to access the email resources 165 on the client devices 120.In one embodiment, the access control service 174 may query the data store 153 of the access control server 150 to determine whether any such resource rules 171 apply to the email resources 165.In another embodiment, the access control service 174 may query the email services 1202 to determine whether any such resource rules 171 apply to the email resources 165.In yet another embodiment, the access control service 174 may query the client devices 120 to determine whether any such resource rules 171 apply to the email resources 165.In any instance, the access control service 174 may analyze the state of the email resources 165 to determine whether the email resources 165 comply with the resource rules 171.In one embodiment, the access control service 174 may determine whether the email resources 165 are encrypted with at least one cryptographic key that is associated with the authorized applications.", "For example, the access control service 174 may determine whether the email resources 165 may be decrypted by the authorized applications.", "In another embodiment, the access control service 174 may determine whether the file format of the email resources 165 is associated with the authorized applications.", "For instance, the access control service 174 may determine whether the email resources 165 are formatted with a file extension that is readable by the authorized applications.", "If the access control service 174 determines that the email resources 165 are accessible via the authorized applications, the access control service 174 may refrain from modifying the email resources 165.If, however, the access control service 174 determines that the email resources 165 are not accessible via the authorized applications, then the access control service 174 may enable the email resources 165 to be accessible via the authorized applications on the client devices 120.In certain embodiments, the access control service 174 may modify the email resources 165 to permit the email resources 165 to be accessible via the authorized applications.", "In some embodiments, the access control service 174 may encrypt the email resources 165 based on at least one cryptographic key to enable the authorized applications to access the email resources 165.For example, the email resources 165 may be encrypted by the access control service 174 based at least in part on a cryptographic key that is native to the authorized applications, thereby enabling the authorized applications to decrypt and access the email resources 165.In one embodiment, the email resources 165 may be encrypted by the access control service 174 based at least in part on the advanced encryption standard (AES) cryptographic schema.", "In another embodiment, the email resources 165 may be encrypted by the access control service 174 based at least in part on the data encryption standard (AES) cryptographic schema.", "In any instance, the email resources 165 may be encrypted, and/or obfuscated, by the access control service 174 in a manner that enables the authorized applications to present at least one user of the client devices 120 with a human-readable version of the email resources 165.In other embodiments, the access control service 174 may modify the file format of the email resources 165 to enable the authorized applications to access the email resources 165.For instance, the format of the file extension of the email resources 165 may be changed to a format that is native to the authorized applications, thereby enabling the authorized applications to interpret and access the email resources 165.Thus, if the authorized applications are capable of reading files that are formatted with the “.pdf” file extension, the access control service 174 may change the format of email resources 165 to the “.pdf” file extension to enable the authorized applications to interpret and access the email resources 165.Furthermore, the access control service 174 may authorize the client devices 120 to access the email resources 165.In certain embodiments, the access control service 174 may be configured to transmit at least one email resource 165 to the client devices 120.In one embodiment, the access control service 174 may transmit at least one email resource 165 to the client devices 120 that has been modified to be inaccessible by the client devices 120 via at least one unauthorized application on the client devices 120 and/or has been modified to be accessible by the client devices 120 via at least one authorized application on the client devices 120.In another embodiment, the access control service 174 may transmit at least one email resource 165 to the client devices 120 that has been modified to be accessible by the client devices 120 via at least one authorized application on the client devices 120 and/or that has been modified to be accessible by the client devices 120 via at least one authorized application on the client devices 120.In some embodiments, the access control service 174 may be further configured to transmit at least one instruction to at least one client side application 126 on the client devices 120 that specifies the manner in which the client side applications 126 are authorized to access the email resources 165.In one embodiment, the instructions may specify and/or include at least one resource rule 171, as described herein.", "In another embodiment, the instructions may include at least one cryptographic key that may be used by the client side applications 126 to decrypt and access the email resources 165.FIG.", "14 depicts certain illustrative components for a networked environment 1400 according to various embodiments.", "In certain embodiments, the networked environment 100 may include at least one network 110, at least one client device 120, an access control service 174, and at least one email service 1202.The networked environment 1400 may be similar to the networked environment 1200 in FIG.", "12.While the networked environment 1200 may include the same components as the networked environment 1400, the organization of the components of the two networked environment may differ as shown.", "In particular, the email services 1202 in the networked environment 1400 may communicate directly with the client devices 120, whereas the access control service 174 in the networked environment 1200 must relay all communications between the email services 1202 and client devices 120.The access control service 174 of the networked environment 1400 may be configured to determine which email resources 165 associated with the email services 1202 may be accessed by the client devices 120, control the manner in which the client devices 120 are authorized to access the email resources 165, and may provide the client devices 120 with access to the email resources 165.In certain embodiments, the access control service 174 may determine which email resources 165 associated with the email services 1202 may be accessed by the client devices 120 by configuring the email services 1202.In some embodiments, the access control service 174 may transmit at least one instruction to the email services 1202 that configures the functionality of the email services 1202.As an example, the access control service 174 may utilize an instruction protocol, such as Microsoft PowerShell, to transmit the instructions to an email service 1202, such as a Microsoft Exchange Server.", "In one embodiment, the instructions may specify that the email resources 165 may be accessed by certain authorized applications on the client devices 120 and may not be accessed by certain unauthorized applications on the client devices 120.In another embodiment, the instructions may include at least one cryptographic key and/or file format with which the associated email resources 165 must be modified before the client devices 120 are authorized to access the email resources 165, as described herein.", "In any instance, the instructions may represent and/or specify at least one resource rule 171 (FIG.", "1) associated with the email resources 165 that must be satisfied in order for the client devices 120 to be authorized to access the email resources 165, as described herein.", "Upon receiving the instructions from the access control service 174, the email services 1202 may execute the instructions on behalf of the access control service 174.Consequently, while the access control service 174 may not have any direct control over the email resources 165 in the networked environment 1400, the access control service 174 may nevertheless ensure that the email resources 165 are configured in accordance with certain specifications by remotely configuring the functionality of the email services 1202.Similarly, in certain embodiments, the access control service 174 may determine which email resources 165 associated with the email services 1202 may be accessed by the client devices 120 by configuring at least one client side application 126 on the client devices 120.For instance, the access control service 174 may be associated with a “containerized” client side application 126 on the client devices 120 that is configured to receive at least one email resource 165 from the email services 1202 and control the manner in which other applications on the client devices 120 access the email resources 165 in accordance with instructions from the access control service 174.As described herein, the instructions may represent at least one resource rule 171 that specifies that the email resources 165 may be accessed by certain authorized applications on the client devices 120 and may not be accessed by certain unauthorized applications on the client devices 120, and may include at least one cryptographic key and/or file format with which the email resources 165 must be modified before the client devices 120 are authorized to access the email resources 165.Upon receiving the instructions from the access control service 174, the client side applications 126 may execute the instructions on behalf of the access control service 174.In one embodiment, the client side application 126 may encrypt the email resources 165 based on at least one cryptographic key to prevent the email resources 165 from being accessible by unauthorized applications on the client device 120.In another embodiment, the client side application 126 may encrypt the email resources 165 based on at least one cryptographic key to enable the email resources 165 to be accessible by authorized applications on the client device 120.In yet another embodiment, the client side application 126 may transmit at least one cryptographic key used to encrypt the email resources 165 to at least one authorized application on the client device 120 to enable the authorized applications to access the email resources 165.Thus, while the access control service 174 may not have any direct control over the email resources 165 in the networked environment 1400, the access control service 174 may nevertheless ensure that the email resources 165 are configured in accordance with certain specifications by remotely configuring the functionality of the client side applications 126 on the client devices 120.FIG.", "15 is a flowchart illustrating exemplary functionality performed by a client side application 126 executed by a client device 120 (FIG.", "1) according to certain embodiments.", "It is understood that the flowchart of FIG.", "15 provides merely an example of the many different types of functional arrangements that may be employed to implement the operation of the client side application 126 as described herein.", "As an alternative, the flowchart of FIG.", "15 may be viewed as depicting an example of steps of a method implemented in the client device 120 according to at least one embodiment.", "Beginning with step 1502, the client side application 126 may identify at least one email resource 165 (FIG.", "1) on the client device 120.In one embodiment, the client side application 126 may be configured to identify email resources 165 on the client device 120 by querying the data store 122 (FIG.", "1) of the client device 120 to determine whether the data store 122 contains any email resources 165.In another embodiment, the client side application 126 may be configured to identify email resources 165 on the client device 120 by receiving at least one transmission of the email resources 165 from at least one access control service 174 (FIGS.", "1,12,14) and/or at least one email service 1202 (FIGS.", "12,14), as described herein.", "In yet another embodiment, the client side application 126 may be configured to identify email resources 165 on the client device 120 by determining whether other applications on the client device 120 have access to at least one email resource 165.Next, in step 1504, the client side application 126 may determine whether the email resources 165 are accessible to the client devices 120 via at least one unauthorized application on the client devices 120.In certain embodiments, at least one resource rule 171 (FIG.", "1) may specify that the client devices 120 are not authorized to access the email resources 165 via certain unauthorized applications on the client devices 120.In some embodiments, the resource rules 171 may specify a listing of applications that are not authorized to access the email resources 165 on the client devices 120.In one embodiment, the client side application 126 may query the data store 122 of the client device 120 to determine whether any such resource rules 171 apply to the email resources 165.In another embodiment, the client side application 126 may query at least one access control service 174 and/or at least one email service 1202 associated with the email resources 165 to determine whether any such resource rules 171 apply to the email resources 165.For instance, the client side application 126 may query the access control service 174 and/or email service 1202 from which the client side application 126 received a transmission of email resources 165 to determine whether resource rules 171 apply to such email resources 165.In any instance, the client side application 126 may analyze the state of the email resources 165 to determine whether the email resources 165 comply with the resource rules 171.In one embodiment, the client side application 126 may determine whether the email resources 165 are encrypted based at least in part on at least one cryptographic key that is associated with the unauthorized applications.", "For example, the client side application 126 may determine whether the email resources 165 may be decrypted by the unauthorized applications.", "In another embodiment, the client side application 126 may determine whether the file format of the email resources 165 is associated with the unauthorized applications.", "For instance, the client side application 126 may determine whether the email resources 165 are formatted with a file extension that is readable by the unauthorized applications.", "If the client side application 126 determines that the email resources 165 are not accessible via the unauthorized applications, the client side application 126 may proceed to step 1506.In particular, if the client side application 126 determines that the email resources 165 in their present state are inaccessible via the unauthorized applications, then the client side application 126 may refrain from modifying the email resources 165.If, however, the client side application 126 determines that the email resources 165 may be accessible via the unauthorized applications, then the client side application 126 may proceed to step 1508 to prevent the email resources 165 from being accessible via the unauthorized applications on the client devices 120.In certain embodiments, the client side application 126 may modify the email resources 165 to prevent the email resources 165 from being accessible via the unauthorized applications.", "In some embodiments, the client side application 126 may encrypt the email resources 165 based on at least one cryptographic key to prevent the unauthorized applications from accessing the email resources 165.For example, the email resources 165 may be encrypted by the client side application 126 based at least in part on a cryptographic key that is foreign to the unauthorized applications, thereby preventing the unauthorized applications from decrypting and accessing the email resources 165.In one embodiment, the email resources 165 may be encrypted by the client side application 126 based at least in part on the advanced encryption standard (AES) cryptographic schema.", "In another embodiment, the email resources 165 may be encrypted by the client side application 126 based at least in part on the data encryption standard (AES) cryptographic schema.", "In any instance, the email resources 165 may be encrypted, and/or obfuscated, by the client side application 126 in a manner that prevents the unauthorized applications from presenting at least one user of the client devices 120 with a human-readable version of the email resources 165.In other embodiments, the client side application 126 may modify the file format of the email resources 165 to prevent the unauthorized applications from accessing the email resources 165.For instance, the format of the file extension of the email resources 165 may be changed by the client side application 126 to a format that is foreign to the unauthorized applications, thereby preventing the unauthorized applications from interpreting and accessing the email resources 165.Thus, if the unauthorized applications are incapable of reading files that are formatted with the “.pdf” file extension, the client side application 126 may change the format of email resources 165 to the “.pdf” file extension to prevent the unauthorized applications from interpreting and accessing the email resources 165.Additionally, the client side application 126 may determine whether the email resources 165 may be accessible on the client devices 120 via at least one authorized application on the client devices 120.In certain embodiments, at least one resource rule 171 may specify that the client devices 120 are authorized to access the email resources 165 via certain authorized applications on the client devices 120.In some embodiments, the resource rules 171 may specify a listing of applications that are authorized to access the email resources 165 on the client devices 120.In one embodiment, the client side application 126 may query the data store 122 of the client device 120 to determine whether any such resource rules 171 apply to the email resources 165.In another embodiment, the client side application 126 may query at least one access control service 174 and/or at least one email service 1202 associated with the email resources 165 to determine whether any such resource rules 171 apply to the email resources 165.For instance, the client side application 126 may query the access control service 174 and/or email service 1202 from which the client side application 126 received a transmission of email resources 165 to determine whether resource rules 171 apply to such email resources 165.In any instance, the client side application 126 may analyze the state of the email resources 165 to determine whether the email resources 165 comply with the resource rules 171.In one embodiment, the client side application 126 may determine whether the email resources 165 are encrypted based on at least one cryptographic key that is associated with the authorized applications.", "For example, the client side application 126 may determine whether the email resources 165 may be decrypted by the authorized applications.", "In another embodiment, the client side application 126 may determine whether the file format of the email resources 165 is associated with the authorized applications.", "For instance, the client side application 126 may determine whether the email resources 165 are formatted with a file extension that is readable by the authorized applications.", "If the client side application 126 determines that the email resources 165 are accessible via the authorized applications, the client side application 126 may refrain from modifying the email resources 165.If, however, the client side application 126 determines that the email resources 165 are not accessible via the authorized applications, then the client side application 126 may enable the email resources 165 to be accessible via the authorized applications on the client devices 120.In certain embodiments, the client side application 126 may modify the email resources 165 to permit the email resources 165 to be accessible via the authorized applications.", "In some embodiments, the client side application 126 may encrypt the email resources 165 based on at least one cryptographic key to enable the authorized applications to access the email resources 165.For example, the email resources 165 may be encrypted by the client side application 126 based at least in part on a cryptographic key that is native to the authorized applications, thereby enabling the authorized applications to decrypt and access the email resources 165.In one embodiment, the email resources 165 may be encrypted by the client side application 126 based at least in part on the advanced encryption standard (AES) cryptographic schema.", "In another embodiment, the email resources 165 may be encrypted by the client side application 126 based at least in part on the data encryption standard (AES) cryptographic schema.", "In any instance, the email resources 165 may be encrypted, and/or obfuscated, by the client side application 126 in a manner that enables the authorized applications to present at least one user of the client devices 120 with a human-readable version of the email resources 165.In other embodiments, the client side application 126 may modify the file format of the email resources 165 to enable the authorized applications to access the email resources 165.For instance, the format of the file extension of the email resources 165 may be changed by the client side application 126 to a format that is native to the authorized applications, thereby enabling the authorized applications to interpret and access the email resources 165.Thus, if the authorized applications are capable of reading files that are formatted with the “.pdf” file extension, the client side application 126 may change the format of email resources 165 to the “.pdf” file extension to enable the authorized applications to interpret and access the email resources 165.Furthermore, the client side application 126 may authorize the client device 120 to access the email resources 165.In certain embodiments, the client side application 126 may be configured to transmit at least one email resource 165 to at least one other application on the client device 120.In one embodiment, the client side application 126 may transmit at least one email resource 165 to at least one other application on the client device 120 that has been modified to be inaccessible by the client device 120 via at least one unauthorized application on the client device 120 and/or has been modified to be accessible by the client device 120 via at least one authorized application on the client device 120.In another embodiment, the client side application 126 may transmit at least one email resource 165 to at least one other application on the client device 120 that has been modified to be accessible by the client device 120 via at least one authorized application on the client device 120 and/or has been modified to be accessible by the client device 120 via at least one authorized application on the client device 120.In yet another embodiment, the client side application 126 may transmit at least one email resource 165 to the data store 122 of the client device 120 has been modified to be inaccessible by the client device 120 via at least one unauthorized application on the client device 120 and/or has been modified to be accessible by the client device 120 via at least one authorized application on the client device 120.In some embodiments, the client side application 126 may be further configured to transmit at least one instruction to at least one other application on the client device 120 that specifies the manner in which the applications are authorized to access the email resources 165.In one embodiment, the instructions may specify and/or include at least one resource rule 171, as described herein.", "In another embodiment, the instructions may include at least one cryptographic key that may be used by the applications to decrypt and access the email resources 165.FIG.", "16 is a flowchart illustrating exemplary functionality performed by a computing system according to certain embodiments.", "For example, the computing system may be and/or include include an access control service 174 executed by an access control server 150 (FIG.", "1) and/or a client side application 126 executed by a client device 120 (FIG.", "1), as described herein.", "It is understood that the flowchart of FIG.", "16 provides merely an example of the many different types of functional arrangements that may be employed to implement the operation of the computer system as described herein.", "As an alternative, the flowchart of FIG.", "16 may be viewed as depicting an example of steps of a method implemented in the computing system according to at least one embodiment.", "Beginning with step 1602, the computing system may identify at least one email resource 165 (FIG.", "1).", "In one embodiment, the computing system may identify email resources 165 by receiving the email resources 165 from an email service 1202 (FIGS.", "12, 14), access control service 174, and/or client device 120 associated with the email resources 165.In another embodiment, the computing system may query the data stores of an email server, access control server 150, and/or client device 120 to determine whether the data stores hold email resources 165.Next, in step 1604, the computing system may determine whether the email resources 165 are accessible to at least one client device 120 via at least one unauthorized application on the client devices 120.As described herein, at least one resource rule 171 (FIG.", "1) may specify that client devices 120 are not authorized to access the email resources 165 via certain unauthorized applications on the client devices 120, which may include a listing of certain unauthorized applications.", "In certain embodiments, the computing system may receive at least one resource rule 171 associated with the email resources 165 from an email service 1202 (FIGS.", "12, 14), access control service 174, and/or client device 120 associated with the email resources 165.In some embodiments, the computing system may query the data stores of an email service 1202 (FIGS.", "12, 14), access control service 174, and/or client device 120 associated with the email resources 165 to determine whether the data stores hold resource rules 171 associated with the email resources 165.In any instance, the computing system may analyze the state of the email resources 165 to determine whether the email resources 165 comply with the resource rules 171.In one embodiment, the computing system may determine whether the email resources 165 are encrypted based at least in part on at least one cryptographic key that is associated with the unauthorized applications, which may determine whether the email resources 165 may be decrypted by the unauthorized applications.", "In another embodiment, the computing system may determine whether the file format of the email resources 165 is associated with the unauthorized applications, which may determine whether the email resources 165 are formatted with a file extension that is readable by the unauthorized applications.", "If the computing system determines that the email resources 165 are not accessible via the unauthorized applications, the computing system may proceed to step 1606.In particular, if the computing system determines that the email resources 165 in their present state are inaccessible via the unauthorized applications on client devices 120, then the computing system may refrain from modifying the email resources 165.If, however, the computing system determines that the email resources 165 may be accessible via the unauthorized applications on client devices 120, then the computing system may proceed to step 1608 to prevent the email resources 165 from being accessible via the unauthorized applications on the client devices 120.In certain embodiments, the computing system may modify the email resources 165 to prevent the email resources 165 from being accessible via the unauthorized applications on the client devices 120.In some embodiments, the computing system may encrypt the email resources 165 based on at least one cryptographic key to prevent the unauthorized applications from accessing the email resources 165, such as a cryptographic key that is foreign to the unauthorized applications to prevent the unauthorized applications from decrypting and accessing the email resources 165.For instance, the email resources 165 may be encrypted by the computing system based at least in part on the advanced encryption standard (AES) cryptographic schema and/or the data encryption standard (AES) cryptographic schema.", "In any instance, the email resources 165 may be encrypted, and/or obfuscated, by the computing system in a manner that prevents the unauthorized applications from presenting at least one user of the client devices 120 with a human-readable version of the email resources 165.In other embodiments, the computing system may modify the file format of the email resources 165 to prevent the unauthorized applications on the client devices 120 from accessing the email resources 165.For instance, the format of the file extension of the email resources 165 may be changed by the computing system to a format that is foreign to the unauthorized applications, thereby preventing the unauthorized applications from interpreting and accessing the email resources 165.Additionally, the computing system may determine whether the email resources 165 may be accessible on the client devices 120 via at least one authorized application on the client devices 120.As described herein, at least one resource rule 171 may specify that the client devices 120 are authorized to access the email resources 165 via certain authorized applications on the client devices 120, which may include a listing of applications that are authorized to access the email resources 165 on the client devices 120.Consequently, the computing system may analyze the state of the email resources 165 to determine whether the email resources 165 comply with the resource rules 171.In one embodiment, the computing system may determine whether the email resources 165 are encrypted based at least in part on at least one cryptographic key that is associated with the authorized applications, which may determine whether the email resources 165 may be decrypted by the authorized applications.", "In another embodiment, the computing system may determine whether the file format of the email resources 165 is associated with the authorized applications, which may determine whether the email resources 165 are formatted with a file extension that is readable by the authorized applications.", "If the computing system determines that the email resources 165 are accessible via the authorized applications, the computing system may refrain from modifying the email resources 165.If, however, the computing system determines that the email resources 165 are not accessible via the authorized applications, then the computing system may enable the email resources 165 to be accessible via the authorized applications on the client devices 120.In certain embodiments, the computing system may modify the email resources 165 to permit the email resources 165 to be accessible via the authorized applications on the client devices 120.In some embodiments, the computing system may encrypt the email resources 165 based on at least one cryptographic key to enable the authorized applications to access the email resources 165, such as with a cryptographic key that is native to the authorized applications that enables the authorized applications to decrypt and access the email resources 165.In other embodiments, the computing system may modify the file format of the email resources 165 to enable the unauthorized applications on the client devices 120 to access the email resources 165, such as to a format that is native to the authorized applications to prevent the authorized applications to interpret and access the email resources 165.Furthermore, the computing system may authorize the client devices 120 to access the email resources 165.In certain embodiments, the computing system may be configured to transmit at least one email resource 165 to the client devices 120, such as email resources 165 that have been modified to be inaccessible by the client devices 120 via at least one unauthorized application on the client devices 120 and/or have been modified to be accessible by the client devices 120 via at least one authorized application on the client devices 120.In some embodiments, the computing system may be further configured to transmit at least one instruction to at least one client side application 126 on the client devices 120 that specifies the manner in which the client side applications 126 are authorized to access the email resources 165, which may include at least one resource rule 171 and/or at least one cryptographic key that may be used by the client side applications 126 to decrypt and access the email resources 165 on the client devices 120 as described herein.", "FIG.", "17 shows schematic block diagrams of an exemplary access control server 150 and an exemplary client device 120 according to an embodiment of the present disclosure.", "The access control server 150 includes at least one processor circuit, for example, having a processor 1703 and a memory 1706, both of which are coupled to a local interface 1709.To this end, the access control server 150 may comprise, for example, at least one server computer or like device.", "Similarly, the client device 120 includes at least one processor circuit, for example, having a processor 1753 and a memory 1756, both of which are coupled to a local interface 1759.Additionally, the client device 120 may be in data communication with a display 136 for rendering user interfaces 137 (FIG.", "1) and at least one other I/O device 1763 for inputting and outputting data.", "To this end, the client device 120 may comprise, for example, at least one client computer or like device.", "The following is a general discussion of the components of the access control server 150 and the client device 120.The local interface 1709 and 1759 may comprise, for example, a data bus with an accompanying address/control bus or other bus structure as can be appreciated.", "Stored in the memory 1706 and 1756 are both data and several components that are executable by the processors 1703 and 1753.In particular, with regard to the access control server 150, stored in the memory 1706 and executable by the processor 1703 are an access control service 174 and potentially other applications.", "Additionally, with regard to the client device 120, stored in the memory 1756 and executable by the processor 1753 are a client side application 126 and potentially other applications.", "Also stored in the memory 1706 and 1756 may be a data store 153 and 122 and other data.", "In addition, an operating system may be stored in the memory 1706 and 1756 and executable by the processor 1703 and 1753.It is to be understood that there may be other applications that are stored in the memory 1706 and 1756 and are executable by the processor 1703 and 1753 as can be appreciated.", "Where any component discussed herein is implemented in the form of software, any one of a number of programming languages may be employed such as, for example, C, C++, C#, Objective C, Java, JavaScript, Perl, PHP, Visual Basic, Python, Ruby, Delphi, Flash, or other programming languages.", "A number of software components are stored in the memory 1706 and 1756 and are executable by the processor 1703 and 1753.In this respect, the term “executable” means a program file that is in a form that can ultimately be run by the processor 1703 and 1753.Examples of executable programs may be, for example, a compiled program that can be translated into machine code in a format that can be loaded into a random access portion of the memory 1706 and 1756 and run by the processor 1703 and 1753, source code that may be expressed in proper format such as object code that is capable of being loaded into a random access portion of the memory 1706 and 1756 and executed by the processor 1703 and 1753, or source code that may be interpreted by another executable program to generate instructions in a random access portion of the memory 1706 and 1756 to be executed by the processor 1703 and 1753, etc.", "An executable program may be stored in any portion or component of the memory 1706 and 1756 including, for example, random access memory (RAM), read-only memory (ROM), hard drive, solid-state drive, USB flash drive, memory card, optical disc such as compact disc (CD) or digital versatile disc (DVD), floppy disk, magnetic tape, or other memory components.", "The memory 1706 and 1756 are defined herein as including both volatile and nonvolatile memory and data storage components.", "Volatile components are those that do not retain data values upon loss of power.", "Nonvolatile components are those that retain data upon a loss of power.", "Thus, the memory 1706 and 1756 may comprise, for example, random access memory (RAM), read-only memory (ROM), hard disk drives, solid-state drives, USB flash drives, memory cards accessed via a memory card reader, floppy disks accessed via an associated floppy disk drive, optical discs accessed via an optical disc drive, magnetic tapes accessed via an appropriate tape drive, and/or other memory components, or a combination of any two or more of these memory components.", "In addition, the RAM may comprise, for example, static random access memory (SRAM), dynamic random access memory (DRAM), or magnetic random access memory (MRAM) and other such devices.", "The ROM may comprise, for example, a programmable read-only memory (PROM), an erasable programmable read-only memory (EPROM), an electrically erasable programmable read-only memory (EEPROM), or other like memory device.", "Also, the processor 1703 and 1753 may represent multiple processors, and the memory 1706 and 1756 may represent multiple memories that operate in parallel processing circuits, respectively.", "In such a case, the local interface 1709 and 1759 may be an appropriate network 110 (FIG.", "1) that facilitates communication between any two of the multiple processors 1703 and 1753, or between any two of the memory 1706 and 1756, etc.", "The local interface 1709 and 1759 may comprise additional systems designed to coordinate this communication, including, for example, performing load balancing.", "The processor 1703 and 1753 may be of electrical or of some other available construction.", "Although the access control service 174, client side application 126, and other various systems described herein may be embodied in software or code executed by general purpose hardware as discussed above, as an alternative the same may also be embodied in dedicated hardware or a combination of software/general purpose hardware and dedicated hardware.", "If embodied in dedicated hardware, each can be implemented as a circuit or state machine that employs any one of or a combination of a number of technologies.", "These technologies may include, but are not limited to, discrete logic circuits having logic gates for implementing various logic functions upon an application of at least one data signal, application specific integrated circuits having appropriate logic gates, or other components, etc.", "Such technologies are generally well known by those skilled in the art and, consequently, are not described in detail herein.", "The flowcharts of FIGS.", "2, 3, 13 and 15 show certain functionality and operations performed by the access control service 174 and client side application 126, respectively.", "If embodied in software, each box may represent a module, segment, or portion of code that comprises program instructions to implement the specified logical function(s).", "The program instructions may be embodied in the form of source code that comprises human-readable statements written in a programming language or machine code that comprises numerical instructions recognizable by a suitable execution system such as a processor 1703 and 1753 in a computer system or other system.", "The machine code may be converted from the source code, etc.", "If embodied in hardware, each block may represent a circuit or a number of interconnected circuits to implement the specified logical function(s).", "Although the flowcharts of FIGS.", "2, 3, 13 and 15 show a specific order of execution, it is understood that the order of execution may differ from that which is depicted.", "For example, the order of execution of two or more steps may be scrambled relative to the order shown.", "Also, two or more blocks shown in succession in FIGS.", "2, 3, 13 and 15 may be executed concurrently or with partial concurrence.", "Further, in some embodiments, at least one of the steps shown in FIGS.", "2, 3, 13 and 15 may be skipped or omitted.", "In addition, any number of counters, state variables, warning semaphores, or messages might be added to the logical flow described herein, for purposes of enhanced utility, accounting, performance measurement, or providing troubleshooting aids, etc.", "It is understood that all such variations are within the scope of the present disclosure.", "Also, any logic or application described herein, including the access control service 174 and the client side application 126, that comprises software or code can be embodied in any non-transitory computer-readable medium for use by or in connection with an instruction execution system such as, for example, a processor 1703 and 1753 in a computer system or other system.", "In this sense, the logic may comprise, for example, statements including instructions and declarations that can be fetched from the computer-readable medium and executed by the instruction execution system.", "In the context of the present disclosure, a “computer-readable medium” can be any medium that can contain, store, or maintain the logic or application described herein for use by or in connection with the instruction execution system.", "The computer-readable medium can comprise any one of many physical media such as, for example, magnetic, optical, or semiconductor media.", "More specific examples of a suitable computer-readable medium would include, but are not limited to, magnetic tapes, magnetic floppy diskettes, magnetic hard drives, memory cards, solid-state drives, USB flash drives, or optical discs.", "Also, the computer-readable medium may be a random access memory (RAM) including, for example, static random access memory (SRAM) and dynamic random access memory (DRAM), or magnetic random access memory (MRAM).", "In addition, the computer-readable medium may be a read-only memory (ROM), a programmable read-only memory (PROM), an erasable programmable read-only memory (EPROM), an electrically erasable programmable read-only memory (EEPROM), or other type of memory device.", "It should be emphasized that the above-described embodiments of the present disclosure are merely possible examples of implementations set forth for a clear understanding of the principles of the disclosure.", "Many variations and modifications may be made to the above- described embodiment(s) without departing substantially from the spirit and principles of the disclosure.", "All such modifications and variations are intended to be included herein within the scope of this disclosure and protected by the following claims." ] ]
Patent_15875893
[ [ "Rolling Security Platform", "A method of rolling security for a system that includes multiple server groups, such as a first server group of one or more servers and a second server group of one or more servers.", "The method includes repeatedly initiating rebuilding of the first server group of one or more servers.", "The method also includes repeatedly initiating rebuilding of the second server group of one or more servers.", "The rebuilding of the first server group of one or more servers is staggered in time from the rebuilding of the second server group of one or more servers.", "The servers may be physical servers or virtual machines.", "Rolling security may also be applied to software containers, computing devices within a data center, and computing devices outside of a datacenter." ], [ "1.A system for rolling security, comprising: a first server group of servers; a second server group of servers, each server in the first server group and second server group including software that includes an operating system and an application that supports user sessions; and a non-transitory computer readable medium storing instructions, the instructions when executed by at least one processor cause the at least one processor to: access rolling timing information indicating rebuild timings for the first server group and rebuild timings for the second server group, the rebuild timings for the first server group being staggered in time from the rebuild timings of the second server group; periodically initiate rebuilding of the software of each server of the first server group of servers according to the rebuild timings for the first server group; and periodically initiate rebuilding of the software of each server in the second server group of servers according to the second rebuild timings for the first server group, the rebuilding of the first server group of servers staggered in time from the rebuilding of the second server group of servers.", "2.The system of claim 1, wherein the instructions further cause the at least one processor to: monitor durations of the user sessions; and generate the rolling timing information indicating rebuild timings for the first server group and rebuild timings for the second server group based on the monitored durations of the user sessions.", "3.A non-transitory computer readable medium storing instructions to implement rolling security for a system that includes a first server group of servers and a second server group of servers, the instructions when executed by at least one processor cause the at least one processor to: repeatedly initiate rebuilding of the first server group of servers; and repeatedly initiate rebuilding of the second server group of servers, the rebuilding of the first server group of servers being staggered in time from the rebuilding of the second server group of servers.", "4.The computer readable medium of claim 3, wherein: the repeatedly initiating rebuilding of the first server group comprises initiating rebuilding of software of each server of the first server group; and the repeatedly initiating rebuilding of the second server group comprises initiating rebuilding software of each server of the second server group.", "5.The computer readable medium of claim 3, wherein: the repeatedly initiating rebuilding of the first server group comprises initiating a rebuilding of firmware in each server of the first server group; and the repeatedly initiating rebuilding of the second server group comprises initiating a rebuilding of firmware in each server of the second server group.", "6.The computer readable medium of claim 3, wherein the instructions cause the at least one processor to: repeatedly initiate a password change of each server in the first server group when rebuilding the first server group; and repeatedly initiate a password change of each server in the second server group when rebuilding the second server group.", "7.The computer readable medium of claim 3, wherein the instructions cause the at least one processor to: access rolling timing information indicating first rebuild timings for rebuilding the first server group and second rebuild timings for rebuilding the second server group, the first rebuild timings staggered in time from the second rebuild timings; and wherein the first server group and the second server group are repeatedly rebuilt according to the rolling timing information 8.The computer readable medium of claim 7, wherein each of the servers in the first server group and the second server group host an application that supports user sessions, and the the instructions cause the at least one processor to: monitor durations of the user sessions; and generate the rolling timing information indicating rebuild timings for the first server group and the second server group based on the monitored durations of the user sessions.", "9.The computer readable medium of claim 3, wherein the servers in the first server group and the second server group that are repeatedly rebuilt are physical servers.", "10.The computer readable medium of claim 3, wherein the servers in the first server group and the second server group that are repeatedly rebuilt are virtual machines.", "11.The computer readable medium of claim 3, wherein the system further comprises one or more load balancers to balance network traffic between the first server group and the second server group, and the instructions cause the at least one processor to: repeatedly initiate shutdown preparation mode of the first server group prior to each rebuilding of the first server group, the load balancers preventing new sessions from being established with applications of the first server group while the first server group is in shutdown preparation mode; and repeatedly initiate shutdown preparation mode of the second server group prior to each rebuilding of the second server group, the load balancers preventing new sessions from being established with applications of the second server group while the second server group is in shutdown preparation mode.", "12.The computer readable medium of claim 3, wherein the repeatedly initiating rebuilding of the first server group comprises periodically initiating rebuilding of the first server group; and the repeatedly initiating rebuilding of the second server group comprises periodically initiating rebuilding of the second server group.", "13.A computer implemented method of rolling security for a system that includes a first server group of servers and a second server group of servers, the method comprising: repeatedly initiating rebuilding of the first server group of one or more servers; and repeatedly initiating rebuilding of the second server group of one or more servers, the rebuilding of the first server group being staggered in time from the rebuilding of the second server group.", "14.The method of claim 13, wherein: the repeatedly initiating rebuilding of the first server group comprises initiating rebuilding of software of each server of the first server group; and the repeatedly initiating rebuilding of the second server group comprises initiating rebuilding software of each server of the second server group.", "15.The method of claim 13, wherein: the repeatedly initiating rebuilding of the first server group comprises initiating a rebuilding of firmware in each server of the first server group; and the repeatedly initiating rebuilding of the second server group comprises initiating a rebuilding of firmware in each server of the second server group.", "16.The method of claim 13, further comprising: repeatedly initiating a password change of each server in the first server group when rebuilding the first server group; and repeatedly initiating a password change of each server in the second server group when rebuilding the second server group.", "17.The method of claim 13, further comprising: accessing rolling timing information indicating rebuild timings for rebuilding the first server group and second server group; and wherein the first server group and the second server group are repeatedly rebuilt according to the rolling timing information 18.The method of claim 17, wherein each of the servers in the first server group and the second server group host an application that supports user sessions, and the method further comprises: monitoring durations of the user sessions; and generating the rolling timing information indicating rebuild timings for the first server group and the second server group based on the monitored durations of the user sessions." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>Embodiments of the present disclosure include intelligent methods and systems of providing online security against hackers.", "In one embodiment, disclosed is a system for rolling security.", "The system comprises a first server group of servers and a second server group of servers.", "Each server in the first server group and second server group includes software that includes an operating system and application that supports user sessions.", "A non-transitory computer readable medium stores instructions that, when executed by at least one processor cause the at least one processor to access rolling timing information indicating rebuild timings for the first server group and rebuild timings for the second server group.", "The rebuild timings for the first server group are staggered in time from the rebuild timings of the second server group.", "The instructions also cause the processor to periodically initiate rebuilding of the software of each server of the first server group of servers according to the rebuild timings for the first server group.", "The instructions also cause the processor to periodically initiate rebuilding of the software of each server in the second server group of servers according to the second rebuild timings for the second server group.", "The rebuilding of the first server group of servers is staggered in time from the rebuilding of the second server group of servers.", "In one embodiment, a method of rolling security for a system that includes multiple server groups is disclosed.", "The method includes repeatedly initiating rebuilding of the first server group of one or more servers.", "The method also includes repeatedly initiating rebuilding of the second server group of one or more servers.", "The rebuilding of the first server group of one or more servers is staggered in time from the rebuilding of the second server group of one or more servers.", "In one embodiment, each of the servers in the first and second group include software that is rebuilt repeatedly, such as on a periodic basis.", "The software that is rebuilt can include an operating system, application, and other software.", "In one embodiment, each of the servers in the first and second server group includes a respective firmware.", "Repeatedly initiating rebuilding of the first server group comprises initiating a rebuilding of the respective firmware in each server of the first server group.", "Repeatedly initiating rebuilding of the second server group comprises initiating a rebuilding of the respective firmware in each server of the second server group.", "In one embodiment, each of the servers in the first and second server group includes a respective password.", "The method also comprises repeatedly initiating a password change of each server in the first server group when rebuilding the first server group; and repeatedly initiating a password change of each server in the second server group when rebuilding the second server group.", "In one embodiment, the method comprises accessing rolling timing information indicating rebuild timings for rebuilding the first server group and second server group.", "The first server group and the second server group are repeatedly rebuilt according to the rolling timing information.", "Additionally, each of the servers in the first server group and the second server group host respective applications and support user sessions for the applications, and the method further comprises monitoring durations of the user sessions for the respective applications; and generating the rolling timing information indicating rebuild timings for the first server group and the second server group based on the monitored durations of the user sessions.", "In one embodiment, the servers in the first server group and the second server group that are repeatedly rebuilt are physical servers.", "In one embodiment, the servers in the first server group and the second server group that are repeatedly rebuilt are virtual machines.", "In one embodiment, the system further comprises one or more load balancers to balance network traffic between the first server group and the second server group.", "The method also comprises repeatedly initiating shutdown preparation mode of the first server group prior to each rebuilding of the first server group, the load balancers preventing new sessions from being established with applications of the first server group while the first server group is in shutdown preparation mode.", "The method also comprises repeatedly initiating shutdown preparation mode of the second server group prior to each rebuilding of the second server group, the load balancers preventing new sessions from being established with applications of the second server group while the second server group is in shutdown preparation mode.", "Other embodiments include a non-transitory computer readable medium storing instructions.", "The instructions are executable by at least one processor to cause the at least one processor to perform the method of rolling security.", "Other embodiments may apply rolling security to software containers.", "Other embodiments may apply rolling security to networked computing devices within a datacenter, or computing devices outside of a datacenter." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a Continuation of U.S. application Ser.", "No.", "14/857,775, filed Sep. 17, 2015, which claims priority from U.S.", "Provisional Patent Application No.", "62/105,685, filed on Jan. 20, 2015, the contents of which are incorporated by reference in its entirety.", "BACKGROUND 1.Field The present disclosure relates to computer security against unauthorized access to resources, and more specifically to a rolling security platform for increased security.", "2.Description of Related Art In network communications there are many forms of software and hardware security, including firewalls and intrusion detection and prevention systems.", "But they all fault on one core issue, that if rules are not applied correctly they can open opportunities for unauthorized access.", "Operating systems and applications today also have many bugs which if exposed to the internet, can enable remote access to servers hosting the applications.", "SUMMARY Embodiments of the present disclosure include intelligent methods and systems of providing online security against hackers.", "In one embodiment, disclosed is a system for rolling security.", "The system comprises a first server group of servers and a second server group of servers.", "Each server in the first server group and second server group includes software that includes an operating system and application that supports user sessions.", "A non-transitory computer readable medium stores instructions that, when executed by at least one processor cause the at least one processor to access rolling timing information indicating rebuild timings for the first server group and rebuild timings for the second server group.", "The rebuild timings for the first server group are staggered in time from the rebuild timings of the second server group.", "The instructions also cause the processor to periodically initiate rebuilding of the software of each server of the first server group of servers according to the rebuild timings for the first server group.", "The instructions also cause the processor to periodically initiate rebuilding of the software of each server in the second server group of servers according to the second rebuild timings for the second server group.", "The rebuilding of the first server group of servers is staggered in time from the rebuilding of the second server group of servers.", "In one embodiment, a method of rolling security for a system that includes multiple server groups is disclosed.", "The method includes repeatedly initiating rebuilding of the first server group of one or more servers.", "The method also includes repeatedly initiating rebuilding of the second server group of one or more servers.", "The rebuilding of the first server group of one or more servers is staggered in time from the rebuilding of the second server group of one or more servers.", "In one embodiment, each of the servers in the first and second group include software that is rebuilt repeatedly, such as on a periodic basis.", "The software that is rebuilt can include an operating system, application, and other software.", "In one embodiment, each of the servers in the first and second server group includes a respective firmware.", "Repeatedly initiating rebuilding of the first server group comprises initiating a rebuilding of the respective firmware in each server of the first server group.", "Repeatedly initiating rebuilding of the second server group comprises initiating a rebuilding of the respective firmware in each server of the second server group.", "In one embodiment, each of the servers in the first and second server group includes a respective password.", "The method also comprises repeatedly initiating a password change of each server in the first server group when rebuilding the first server group; and repeatedly initiating a password change of each server in the second server group when rebuilding the second server group.", "In one embodiment, the method comprises accessing rolling timing information indicating rebuild timings for rebuilding the first server group and second server group.", "The first server group and the second server group are repeatedly rebuilt according to the rolling timing information.", "Additionally, each of the servers in the first server group and the second server group host respective applications and support user sessions for the applications, and the method further comprises monitoring durations of the user sessions for the respective applications; and generating the rolling timing information indicating rebuild timings for the first server group and the second server group based on the monitored durations of the user sessions.", "In one embodiment, the servers in the first server group and the second server group that are repeatedly rebuilt are physical servers.", "In one embodiment, the servers in the first server group and the second server group that are repeatedly rebuilt are virtual machines.", "In one embodiment, the system further comprises one or more load balancers to balance network traffic between the first server group and the second server group.", "The method also comprises repeatedly initiating shutdown preparation mode of the first server group prior to each rebuilding of the first server group, the load balancers preventing new sessions from being established with applications of the first server group while the first server group is in shutdown preparation mode.", "The method also comprises repeatedly initiating shutdown preparation mode of the second server group prior to each rebuilding of the second server group, the load balancers preventing new sessions from being established with applications of the second server group while the second server group is in shutdown preparation mode.", "Other embodiments include a non-transitory computer readable medium storing instructions.", "The instructions are executable by at least one processor to cause the at least one processor to perform the method of rolling security.", "Other embodiments may apply rolling security to software containers.", "Other embodiments may apply rolling security to networked computing devices within a datacenter, or computing devices outside of a datacenter.", "BRIEF DESCRIPTION OF THE DRAWINGS Figure (FIG.", "1A is a block diagram of networked communication system with components of a secured datacenter for rolling security, according to an embodiment.", "FIG.", "1B is a block diagram of networked communication system with components of a secured datacenter for rolling security, according to another embodiment.", "FIG.", "1C is a block diagram of networked communication system with components of a secured datacenter for rolling security, according to a further embodiment.", "FIG.", "2A is a block diagram of a frontend server from FIG.", "1A, according to an embodiment.", "FIG.", "2B is a block diagram of a server with virtual machines, according to an embodiment.", "FIG.", "2C is a block diagram of a server with software containers, according to an embodiment.", "FIG.", "3 is a diagram of rolling server groups, according to an embodiment.", "FIG.", "4 is a block diagram of a security control module, according to an embodiment.", "FIG.", "5 is a flowchart for a method of rolling security, according to an embodiment.", "FIG.", "6 illustrates the hardware architecture of a computing device.", "DETAILED DESCRIPTION Reference will now be made in detail to several embodiments of the present disclosure, examples of which are illustrated in the accompanying figures.", "It is noted that wherever practicable similar or like reference numbers may be used in the figures and may indicate similar or like functionality.", "The figures depict embodiments of the present disclosure for purposes of illustration only.", "One skilled in the art will readily recognize from the following description that alternative embodiments of the structures and methods illustrated herein may be employed without departing from the principles, or benefits touted, of the disclosure described herein.", "The present disclosure relates to a system platform that prevents hackers from gaining access to backend datasets and prevents ongoing access to any dataset.", "More particularly, this invention can stop escalating access to unauthorized resources for a higher security solution.", "In one embodiment, a security platform for a datacenter is disclosed.", "The security platform continually and repeatedly rebuilds itself in a rolling manner based on specific metrics of time.", "The rolling security will automatically replace server software in short periods of time to completely wipe out any configuration or holes found in operating systems or applications, thereby limiting access to any server to a short period of time.", "For example, this time can be as short as 10 seconds or as long as hours.", "In one embodiment, a standard configuration will default to 10 min between rebuilds.", "Hackers will have such a short window in which to learn the hack, figure out what the architecture is in the backend, compromise the server and try to install a root kit for further access.", "Thus, it is pointless for the hackers to attempt to complete their hack as the replacement of the server happens so often.", "By the time a hacker discovers a password or public key infrastructure (PKI) key, the operating system (OS) is being replaced along with new passwords and keys.", "The system can, but is not limited to, replace the whole software stack on a device including the OS, applications, content, data and cache within a short period of time.", "The system can be fully integrated with multiple devices in a network (e.g.", "load balancer, firewalls, etc) to seamlessly manage both real users and hacker users.", "In other embodiments, session count, connection count, unique sensor triggers and other security indications can be used to trigger rebuilds.", "In other embodiments, a session can be dynamically contained into an isolated environment and a time of the session can extended to learn the hacks being performed in an isolated environment.", "The system can dynamically learn the applications average session counter and time and adjust the rebuild timing dynamically or have a manual configuration to enable tighter security policies.", "The system limits the time any single session can be connected to a front end application and dataset to prevent long term remote access to any system.", "FIG.", "1A is a block diagram of networked communication system with components of a secured datacenter for rolling security, according to an embodiment.", "The system includes several client devices 105, a network 110, a router 115, frontend firewalls 120A-C, load balancers 125A-C, frontend server groups 130A-130D, backend firewalls or load balancers 132A-C, backend server groups 135A-135D, storage systems 140A-140D and security server 148.Routers, firewalls 120, load balancer 125, frontend servers 130, firewall 132, backend server 135, and storage systems 140 may be components of a datacenter.", "Only a limited number of devices are shown in FIG.", "1A, but in other embodiments there may be a larger number of devices (e.g.", ">four frontend server groups).", "Client devices 105 can be computing devices, such as smartphones, tablet computers, laptop computers, and desktop computers, among others.", "A user interacts with software of the client devices 105 through an interface, such as a touchscreen or mouse and keyboard.", "The client devices 105 are controlled by the user to establish application sessions and connections with various applications hosted by the frontend server groups 130.The router 115 routes network traffic between the network 110 and the rest of the components in the datacenter.", "The frontend firewalls 120 are hardware based firewall devices that control incoming and outgoing network traffic using an applied rule set.", "A firewall establishes a barrier between the internal network of the datacenter and the external network 110.The load balancers 125 distribute network traffic across a large number of frontend server groups 130.The load balancers increase capacity and reliability of applications by decreasing the burden on any one particular frontend server group 130.Each frontend server group 130 includes several physical frontend servers.", "A server is a server class computing device that can include one or more processors and executes an operating system.", "A server hosts several software applications.", "The clients 105 can establish networking connections and application sessions with the applications hosted by the frontend servers.", "For security purposes, each server group can be rolled (i.e.", "by rebuilding the server group) after expiration of an amount of time and the server groups can be rolled in staggered manner.", "Copies of the same application are hosted by multiple server groups 130 so that, even as the server groups are rolled, the application is still available to the client devices 105.In one embodiment there are a total of nine frontend server groups 130 and each frontend server group 130 includes thousands of frontend servers.", "The backend firewalls 132 are hardware based firewall devices, or virtual firewalls, that control traffic between the frontend server groups 130 and backend server groups 135 using an applied rule set.", "Each backend server group 135 includes one or more backend servers.", "Backend servers permit access to the data stored in the storage systems 140.Backend servers store and retrieve data from the storage systems 140 as requested by the applications hosted by the frontend servers groups 130.An example of a backend server is a SQL server that provides access to a SQL database.", "Security server 148 includes a security control module 150 that coordinates rolling operation of the frontend server groups 130.Specifically, the security control module 150 repeatedly initiates rebuilds of the frontend server groups 130 at periodic and staggered intervals.", "Rebuilding a server can include replacing the entire software stack of a server, including the operating system (OS), applications, content, data and caches by replacing a hard drive image of the server with a known good replacement image.", "Rebuilding a server can also include replacing the firmware of a server.", "Rebuilding may also include other operations in addition to these operations.", "The time between rebuilds can be as short as 10 seconds or as long as hours.", "In other embodiments the standard rebuild time will default to 10 min.", "Repeatedly rebuilding servers on a periodic and frequent basis forces hackers to complete their hack in a short amount of time (e.g.", "under 5 seconds) which is near impossible as response times and upload times usually require a greater amount of time.", "For example, for a DNS server, the DNS server can be rebuilt every 10 seconds with a new OS and DNS database cache.", "In this situation, hackers will not have time to hack the protocol and upload bogus data by cache spoofing.", "Any malicious code uploaded by the hackers will also be eliminated.", "Everything tied to the server will be replaced, making it impossible to remote into the OS from outside.", "At the same time, all the content needed for standard customer requests are served correctly.", "This completely solves any holes found in today's software.", "The security control module 150 also initiates the rebuilds on a rolling basis by staggering the rebuilding of each frontend server group (e.g.", "130A) in time relative to the other frontend server groups (e.g.", "130B).", "Each frontend server group 130 will start servicing user sessions at different times creating a staggering approach to when a server group 130 will come online and start serving traffic.", "The process from which a session starts and ends all happens within a single server or group of servers 130.This allows for simple load balancing within the group but also allows for termination of a session to happen within the group.", "The servers within a server group 130 will replace their OS at the same time while other server groups 130 are just coming online and servicing the new user sessions.", "The timeframe to rebuild a server group 130 can vary depending on the functionality of the applications in the server groups 130.The security control module 150 also communicates with the load balancers 125 such that the load balancers 125 are aware of the server group being shut down for new OS installs, thereby allowing the load balancers 125 to distribute network traffic only to server groups 130 that are online.", "The security control module 150 can transmit information to the load balancers 125 to indicate when a server group 130 is beginning preparation for shutting down.", "In response, the load balancers 125 take the server group 130 offline and prevent new connections from being established with the server group 130.Once the server group 130 is rebuilt, the security control module 150 can transmit information to the load balancers 125 indicating that the server group 130 is ready to accept new connections.", "In response, the load balancers 125 put the server group 130 back online and allows new connections to be established with the server group 130 The security control module 150 can also change the password of the server groups 130 when rebuilding the server groups 130.Frequent password changes make it impossible to do password attacks on servers.", "The security control module 150 can be implemented as software, hardware, or as a combination of hardware and software.", "In other embodiments, the security control module 150 can be distributed across one or more components of the datacenter other than the security server 148.FIG.", "1B is a block diagram of networked communication system with components of a secured datacenter for rolling security, according to another embodiment.", "FIG.", "1B is similar to FIG.", "1A except that it now includes frontend virtual machine (VM) groups 160 and hypervisors 190.Each VM group 160 includes one or more VMs.", "A VM is an emulation of a computer system, such as an emulation of a computer server.", "Each VM may be attached to its own virtual disk.", "A VM may be referred to herein as a virtual server.", "Hypervisor 190 creates and manages the VMs groups 160.Each hypervisor 190 may be located on its own physical front end server 159, and also control a group of VMs 160 that are located on the same physical front end server.", "For example, Hypervisor 190A and VM group 160A are located on a single physical server 159A.", "In this embodiment, the security control module 150 provides rolling security to the networked communication system by periodically initiating rebuilds of the frontend VM groups 160 (i.e.", "virtual server groups).", "Copies of the same application are hosted by multiple VM groups 160 so that the application is always online even as the VM groups 160 are being rebuilt.", "Rebuilding a VM can include restoring the state of a VM to an original known good state.", "Rebuilding will be explained in greater detail below.", "Otherwise the operation of the security control module 150 is the same as that described in conjunction with FIG.", "1A.", "In one embodiment, the networked communication system may include both physical server groups and virtual server groups that are rebuilt on a periodic and staggered basis.", "FIG.", "1C is a block diagram of networked communication system with components of a secured datacenter for rolling security, according to a further embodiment.", "FIG.", "1C is similar to FIG.", "1B except that it now includes container groups 960 and container engines 990 located on the servers 159.Each container group 960 includes one or more software containers used for operating system level virtualization.", "A software container includes an application, its dependencies, libraries and binaries bundled into a single package.", "A software container shares an operating system (not shown) with other software containers on the same server 159.A software container is instantiated within the kernel of the operation system and virtualizes the instance of the application.", "Software containers allow for rapid creation of an application or service to be put into a block of resources.", "The deployment of a container is fast because containers can share core library files from the core OS.", "The software containers are managed by a container engine 990.In one embodiment, the software containers 960 are DOCKER containers or are compliant with the open container project standard.", "In this embodiment, the security control module 150 provides rolling security to the networked communication system by periodically initiating rebuilds of the container groups 960 on a rolling basis.", "Copies of the same application are included in multiple container groups 960 so that the application is always online even as some of the container groups 960 are being rebuilt.", "A container can be rebuilt by restoring the container to a known good state.", "Rebuilding will be explained in greater detail below.", "Otherwise the operation of the security control module 150 is the same as that described in conjunction with FIGS.", "1A and 1B.", "In one embodiment, rebuilding containers can be more efficient than rebuilding physical servers and virtual machines.", "For example, containers can be restored and deployed in ˜30 seconds.", "By contrast, rebuilding servers and virtual machines can take much longer.", "Although rolling containers can be easier than rolling physical servers and VMs, they have higher risks due to the use of shared core OS files.", "Hypervisor architectures also have risk, but because the OS is dedicated to each VM, it reduces the risk compared to a container platform.", "The risk is lower again when rolling physical servers as a hacker will need to have BIOS level control of a server to do server hijacking, or the hacker will need remote management tools access.", "The description herein may primarily focus on the rolling of physical servers or virtual machines.", "However, the principles of rolling security described herein are applicable to rolling of physical servers, virtual machines, or containers.", "FIG.", "2A is a block diagram of a frontend server 200, according to an embodiment.", "Frontend server 200 may represent a frontend server from the frontend server groups 130 of FIG.", "1A.", "Frontend server 200 includes several software applications 250A-C, an OS 152, firmware 154 and a frontend security module 156.Examples of OS 152 include LINUX and MICROSOFT WINDOWS, among others.", "The applications 250 are executed on top of the OS 152.The firmware 154 includes software that is stored in a programmable memory chip.", "The client devices 105 can establish networking connections C1-C6 with the applications 250.A connection is used as a bidirectional communication channel between sockets at the client devices 105 and the server 200.The connection is established at a certain point in time using a handshake process, and then terminated at a later point in time.", "The connection may include several states defined by a protocol.", "An example of a connection is a transmission control protocol (TCP) connection of the transport layer of the Open Systems Interconnect (OSI) model.", "The client devices 105 also establish application user sessions S1-S6 with the applications 250 over the connections C1-C6.A user session is an interactive information exchange between two or more communicating entities for a given application.", "The user session is established at a certain point in time, and then terminated at a later point in time.", "During the user session, one or more messages may be sent in each direction over a connection that has been established for the session.", "In one embodiment, the application sessions are sessions of the OSI session layer that sit above the transport layer.", "In one example, a credit card authentication session (e.g.", "S1, S2) can be initiated when a user swipes a credit card at a client device 105A, and the client device 105A establishes a connection and session with credit card payment application 250A.", "Credit card payment application 250A communicates with the client device 105A to obtain the credit card number and charge amount from the client device 105A.", "The credit card payment application 250 then accesses the database 140 via backend server 135 to determine if the credit card number has sufficient credit to process the payment.", "The credit card payment application 250 then provides a yes/no response to the client device 105A.", "The connection and session are then terminated after providing the response to the client device 105A.", "In another example, a web form session (e.g.", "S3, S4) can be initiated when a user enters a URL into a browser at a client 105B.", "The client device 105B establishes a session with website 250B.", "The server 200 may be processing multiple sessions.", "The server 200 starts a time counter per session.", "The user has x amount of time to fill out a form before the session closes.", "A different server may process the form submission from the initial session due to the time it takes to fill out the web form data.", "In a further example, an online banking session (e.g.", "S5, S6) can be initiated when a user opens a mobile banking application at the client device 105B, and the client device 105B establishes a connection and session with online banking application 250C.", "Online banking application 250C communicates with the client device 105B to obtain authentication information from the client device 105B.", "Once authenticated, the client device 105B can request account balances, upload copies of checks for deposit, and make other banking requests.", "The banking application 250C can access account information stored in database 140 via backend server 135 to process these requests.", "The connection and session are eventually terminated at the end of the session.", "Frontend security module 156 can communicate with the security control module 150 to send and receive security information to implement rolling security.", "The security module 156 can receive commands to initiate a rebuild of the frontend server 200.The commands can include a name of a golden image, which is a known good master software image that is to be used as a template for the rebuild.", "The security module 156 then rebuilds the frontend server 200 in accordance with the commands, such as by replacing the OS 152, applications and/or firmware 154.The OS 152, applications 250 and/or firmware 154 can replaced by overwriting existing software on the server 200 with the golden image, deleting existing software on the server 200 and copying new software onto the server 200 from the golden image, etc.", "The golden image can be stored locally on a disc within the server 200 or elsewhere on a network.", "Different rebuild techniques with varying rebuild times can be used.", "In one embodiment, a single golden image can be used to rebuild multiple servers 200.Data from the golden image can be copied onto the frontend server 200, and then post process configurations are executed on each frontend server 200 to configure the OS 152 or applications 250.For example, a different script may be executed on each frontend server 200 to establish a unique name for the server and an IP address for the server.", "In one embodiment, there may be multiple golden images that are specific and unique to each frontend server 200.The data from a golden image can be copied onto a respective server without the need for post process configurations, which reduces rebuild time.", "In another embodiment, a data differencing technique is used to rebuild the frontend server 200.Specifically, data blocks or files of the software of a frontend server 200 can be compared to data blocks or files of a golden image.", "Only the data blocks or files that are different are restored from the golden image.", "By leveraging block or file based differencing, rapid deployment of preconfigured OS and app configurations via local disk, remote SAN disks or NAS disks is possible.", "It should be noted that other rebuild techniques may be possible and still fall within the scope of the disclosure.", "In one embodiment, various hash or encryption models or block state comparisons can be applied to a rebuilt software image to verify the rebuild is of standard expected configuration and the state is of a good known configuration.", "For example, the rebuilt software can be hashed and then compared to the hash of the golden image to verify that the rebuild was performed as expected.", "In one embodiment, the frontend security module 156 places a frontend server 200 into a lock down security mode during rebuilds for protection against tampering.", "During rebuilds, the frontend security module 156 may set its internal firewall access control lists (ACL) with permissions that block any traffic to certain ports other than communications with the security control module 150 of the security server 148.An ACL can be a list of network ports, along with specific entities permitted to use the network ports.", "Other 3rd party applications may also be given access on a need basis for verification of state of compliance.", "The security module 156 can also receive a command to change the password of the OS 152 and then replace the password in accordance with the command.", "In one embodiment, the security information is communicated via an intelligent platform management interface (IPMI).", "FIG.", "2B is a block diagram of a frontend server 202 with VMs 204, according to an embodiment.", "Frontend server 202 may represent a frontend server 159 from FIG.", "1B.", "Frontend server 202 includes several VMs 204, hypervisor 208, OS 152, and frontend security module 156A.", "Each VM includes a virtualized OS 206 and applications 250.Frontend security module 156A is similar to frontend module 156, but now rebuilds VMs in response to commands to rebuild the VMs 204.The rebuilding of VMs 204 is similar to the rebuilding described with respect to FIG.", "2A, and can also utilize a golden image of a VM 204 to generate a VM 204, utilize data differencing, and/or perform rebuild verification after rebuilding the VM 204.FIG.", "2C is a block diagram of a frontend server 290 with containers 292, according to an embodiment.", "Frontend server 290 may represent a frontend server 159 from FIG.", "1C.", "Frontend server 290 includes several containers 292, container engine 294, OS 152, and frontend security module 156B.", "Each container includes virtualized applications 250.Frontend security module 156B is similar to frontend module 156, but now rebuilds containers 292 on a rolling basis in response to commands to rebuild the containers 292.The rebuilding of containers 292 is similar to the rebuilding described with respect to FIG.", "2A, and can also utilize a golden image of a container 292 to generate a container 292, utilize data differencing, and/or perform rebuild verification after rebuilding the container 292.FIG.", "3 is a diagram of rolling server groups, according to an embodiment.", "The rolling operation of four server groups 130A-130D is illustrated in FIG.", "3.In other embodiments, the rolling operation shown in FIG.", "3 is also applicable to rolling of VM groups 160 and software container groups 960.Each server group 130 operates in different rolling security modes: (1) a normal operation mode (2) a shutdown preparation mode and (3) a rebuilding mode.", "During the normal operation mode a server group 130 accepts and services new user sessions and connections.", "During the shutdown preparation mode the server group 130 does not accept new sessions and connections.", "Existing sessions and connections are allowed to finish.", "In one embodiment, the load balancers 125 may be notified that a particular server group 130 is being placed into shutdown preparation mode and is not accepting new sessions and connections.", "The load balancers 125 respond by removing the server group 130 from the possible server groups 130 to which new sessions and connections can be made.", "During the rebuilding mode the server group 130 is removed from service and is rebuilt by replacing the software of the server group 130.The modes repeat periodically, such as every 60 seconds.", "The server groups 130 are operated in a rolling manner such that the rebuilding of different server groups is initiated at different times.", "For example, server group 130A is rebuilt at 1:00:50, server group 130B is rebuilt at 1:01:00, server group 130C is rebuilt at 1:01:10, and server group 130D is rebuilt at 1:01:20.The rebuild times are staggered from each other by ten seconds.", "The staggering of rebuild times ensures that there is always at least one server group 130 in service and available to accept new connections and user sessions for applications hosted by the server group 130.In other words, there is always at least one server group 130 that is in normal operation mode.", "In one embodiment, shutdown preparation mode may be delayed for a server group 130 if a security condition indicating the presence of a hacker is triggered.", "A security condition may be triggered, for example, if session is associated with a suspicious IP or has kept the session open for too long.", "In that situation, the security control module 150 may implement deep analytics of the session, containment of the session and recording of the session to better understand a hacker's actions.", "Alternatively, if a security condition is triggered, the security module 150 may take a hacked server, on which hacked session is detected, out of a server group 130.A new server is then hot swapped in place of the hacked server such that the rolling of the server groups 130 is not interrupted.", "FIG.", "4 is a block diagram of a security control module 130, according to an embodiment.", "Security control module 130 includes a communication module 405, rolling timing module 410, rolling control module 415, and password change module 420.In other embodiments the security control module 130 may have additional modules not shown in FIG.", "4.The rolling timing module 410 maintains rolling timing information indicating staggered timings for when the physical server groups 130, VM groups 160, or container groups 960 (collectively referred to herein as “rolling entity groups”) should enter different modes, such as normal operation mode, shutdown preparation mode and rebuilding mode.", "The timing information may be in the form of a timing schedule that includes a list of rolling entity groups and specific times for when each rolling entity group should enter different modes.", "The following table is an example of a timing schedule.", "Server Mode:Normal Mode:Shutdown Group Operation Preparation Mode:Rebuilding 1 1:00:00 1:00:30 1:00:50 1:01:00 1:01:30 1:01:50 .", ".", ".", ".", ".", ".", ".", ".", ".", "2 1:00:10 1:00:40 1:01:00 1:01:10 1:01:40 1:02:00 .", ".", ".", ".", ".", ".", ".", ".", ".", "3 1:00:20 1:00:50 1:01:10 1:01:20 1:01:50 1:02:10 .", ".", ".", ".", ".", ".", ".", ".", ".", "4 1:00:30 1:01:00 1:01:20 1:01:30 1:02:00 1:02:20 .", ".", ".", ".", ".", ".", "...", "The first column of the table identifies a server group.", "The second column identifies start times for when the server group should enter the normal operation mode.", "The third column identifies when the server group should enter shutdown preparation mode.", "The fourth column identifies when the rebuilding process should begin.", "In other embodiments, the timing information may be in the form of maximum time limits instead of a timing schedule.", "For example, the timing information may include a maximum uptime of a rolling entity group, a maximum duration of a normal operation mode, a maximum duration of a shutdown preparation mode, and/or a maximum duration of a rebuild mode.", "The timing information may also include information describing an amount of staggered delay between the rolling entity groups.", "The rolling timing information for the rolling modes may be manually set by a user.", "In another embodiment, the timing information may be machine learned by monitoring the durations of previous application sessions or connections on the servers and generating application profiles that include the monitored durations.", "A statistical measure of the durations (e.g.", "average duration, maximum duration) can be determined from the monitored durations.", "The statistical measure is then multiplied by a multiplier (e.g.", "8×, 10×) to determine the maximum duration of each rolling mode.", "The result is that the time between rebuilds is sufficient for new user sessions and connections to be established and completed before a rolling entity group is rebuilt.", "For example, if user sessions tend to be 6 seconds long, this value may be multiplied by 8× to result in a duration between periodic rebuilds of 48 seconds, which is much greater than the session duration.", "Rolling control module 415 controls the rolling operation of the rolling entity groups in accordance with the rolling timing information, such as the rolling timing schedule or the maximum time limits described above.", "The rolling control module 415 uses the rolling timing information to determine the rolling mode that a server group should be in.", "The rolling control module 415 then sends control commands to the load balancers 125 and rolling entity groups via the communication module 405 that cause the rolling entity groups to operate in a rolling manner as shown in FIG.", "3.The commands for each rolling entity group may be staggered in time relative to commands for the other rolling entity groups to ensure that the rolling entity groups are rolled at controlled and staggered times.", "To initiate normal operation mode, the rolling control module 415 may transmit a normal operation initiation command to the load balancers 125.The command identifies a particular rolling entity group and also indicates that normal operation mode is to begin for that rolling entity group.", "The load balancer 125 responds to the command by allowing sessions and connections to be established with the identified rolling entity group.", "In one embodiment the normal operation initiation command may also be transmitted to the appropriate rolling entity group for which normal operation is being initiated.", "To initiate shutdown preparation mode, the rolling control module 415 may transmit a shutdown preparation initiation command to the load balancers 125.The command identifies a particular rolling entity group and also indicates that shutdown preparation mode is to begin for that rolling entity group.", "The load balancer 125 responds to the command by preventing any new sessions and connections to be established with the identified rolling entity group.", "Existing sessions and connections of the rolling entity group are permitted to complete.", "In one embodiment the shutdown preparation initiation command may also be transmitted to the appropriate servers for a rolling entity group.", "To initiate rebuilding, the rolling control module 415 may send a rebuild initiation command to the appropriate front end server(s) associated with a rolling entity group that is to be rebuilt.", "The command can include a name of a known good software image that is to be used for the rebuild.", "In response, the rolling entity group can be rebuilt with the known good software image.", "The rolling control module 415 may also receive rebuild confirmation information from the appropriate front end servers once the rebuild is completed.", "Additionally, prior to rebuilding, rolling control module 415 can copy data from a rolling entity group to a separate storage drive.", "Machine learning can be used to monitor for changes in the data and do an inline analysis of the changes for global comparison across other servers.", "This allows for understanding of all the changes made by a hacker to the OS, applications, or files while an entity was online.", "Machine learning the rebuild state and timing is important but delaying the rebuild state over a hacked situation to enable more advanced learning is also part of the system controls managed via the rolling control module 415.Rolling control module 415 can also communicate with the local server groups, router 115 and firewall 120 to continue servicing a hacker with the intention of learning and collection more data to learn the hackers capabilities and learn more about new attacks.", "Password change module 420 initiates password changes for the server groups 130.The passwords can be OS, database, or application passwords, among others.", "The passwords can be changed with every rebuild as indicated by the rolling timing information, or can be rebuilt at specific timestamps (i.e.", "at certain intervals).", "The frequency of the password changes can be the same as or different than the frequency of the rolling entity group rebuilds.", "In one embodiment, the password change module 420 can initiate a password change by generating new passwords and transmitting the passwords to the servers.", "In another embodiment, the password change module 420 can initiate a password change by sending a password change command to the servers.", "The servers then generate new passwords in response to the command.", "Any of a number of algorithms can be used to generate the password.", "In one embodiment, a timestamp is one of the elements used to generate the password.", "Communication module 405 communicates with the servers, load balancers 125, and other devices in the networked communication system.", "The communication module 405 may transmit rolling security commands that cause the rolling entity groups to operate in a rolling and staggered manner.", "The communication module 405 may send commands that initiate password changes at the rolling entity groups.", "The communication module 405 may also receive other types of information from the devices in the networked communication system.", "FIG.", "5 is a flowchart for a method of rolling security, according to an embodiment.", "In step 505, previous connections or user sessions for applications hosted by the rolling entity groups are monitored.", "The durations are stored in application profiles.", "Once sufficient information is collected, the durations for the previous connections and user sessions is used to generate rolling timing information that describes staggered timings for different rolling security modes of the rolling entity groups, such as staggered timing for when different rolling entity groups should be rebuilt.", "In step 510, the security control module 150 initiates normal operation of the first rolling entity group at a timing specified by the rolling timing information.", "In step 512, the security control module 150 initiates shutdown preparation mode of the rolling entity group at a timing specified by the rolling timing information.", "In step 514, the security control module 150 initiates rebuilding of the first rolling entity group at a timing specified by the rolling timing information.", "Additionally, the security control module 150 initiates a password change of the first rolling entity group at the same time.", "Steps 510-514 repeat continuously, such as at periodic intervals.", "In step 520, the security control module 150 initiates normal operation of the second rolling entity group at a timing specified by the rolling timing information.", "In step 522, the security control module 150 initiates shutdown preparation mode of the second rolling entity group at a timing specified by the rolling timing information.", "In step 524, the security control module 150 initiates rebuilding of the second rolling entity group at a timing specified by the rolling timing information.", "Additionally, the security control module 150 initiates a password change of the second rolling entity group at the same time.", "Steps 520-524 repeat continuously, such as at periodic intervals.", "Other rolling entity groups may also be controlled in a similar manner as steps 510-514 and 520-524.Additionally, for each rolling entity group, the initiation of the rebuilding, normal operation modes, and shutdown preparation modes is staggered in time relative to the other rolling entity groups.", "Staggering of the security modes results in the rolling security illustrated in FIG.", "3.FIG.", "6 illustrates the hardware architecture of a computing device, such as a firewall 120, router 115, load balancer 125, client device 105, frontend server 130 or 159, backend server 135, or security server 148, according to one embodiment.", "In one embodiment, the computing device is a computer including components such as a processor 602, a memory 603, a storage module 604, an input module (e.g., keyboard, mouse, and the like) 606, a display module 607 and a communication interface 605, exchanging data and control signals with one another through a bus 601.The storage module 604 is implemented as one or more non-transitory computer readable storage media (e.g., hard disk or solid state drive), and stores software instructions 640 (e.g.", "modules) that are executed by the processor 602 in conjunction with the memory 603 to implement the rolling security features described herein.", "Operating system software and other application software may also be stored in the storage module 604 to run on the processor 602.The rolling security described herein is not only limited to front end servers 130, virtual machines 160, and containers 960.In other embodiments the rolling security can be used to periodically rebuild other groups of computing systems in a datacenter, such as firewalls 120, load balancers 125, switches, backend servers 135 and backend storage 140.Additionally, the functions of the modules described herein may be combined into a single module or distributed across additional modules.", "In other embodiments, the rolling security described herein may be applied to other groups of computing systems outside of datacenters that provide common software functionality.", "The computing systems can be desktops, laptops, ipads, iphones, and computing systems in vehicles (cars, trains, planes) and computing systems in power plants, generators, etc.", "In the example of a plane, the plane may include several parallel flight control systems, each of which can provide flight control for the plane.", "Rolling the flight control systems on a staggered basis can protect the flight control systems from being hacked while ensuring that at least one flight control system is always online.", "Upon reading this disclosure, those of skill in the art may appreciate still additional alternative designs for rolling security.", "Thus, while particular embodiments and applications of the present disclosure have been illustrated and described, it is to be understood that the disclosure is not limited to the precise construction and components disclosed herein.", "Various modifications, changes and variations which may be apparent to those skilled in the art may be made in the arrangement, operation and details of the method and apparatus of the present disclosure herein without departing from the spirit and scope of the disclosure as defined in the appended claims." ] ]
Patent_15875894
[ [ "TOTAL HIP REPLACEMENT SURGICAL GUIDE TOOL", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery.", "The surgical guide tool may include a customized mating region and a resection guide.", "The customized mating region and the resection guide are referenced to each other such that, when the customized mating region matingly engages a surface area of a proximal femur, the resection guide will be aligned to guide a resectioning of the proximal femur along a preoperatively planned resection plane." ], [ "1.A method of preparing a proximal femur of a patient for implantation of a femoral implant as part of a total hip arthroplasty procedure, the method comprising: a) preoperatively planning the total hip arthroplasty procedure on the proximal femur of the patient, the preoperative planning including: i) causing a first center and a second center to positionally correspond in a computer coordinate system, wherein the first center is a center of a femoral head of a three dimensional computer model of the proximal femur and the second center is a center of a femoral head of a three dimensional computer model of the femoral implant; and ii) computer defining a resection of the proximal femur in the computer coordinate system when the first and second centers positionally correspond in the computer coordinate system; and b) resecting the proximal femur of the patient according to the computer defined resection.", "2.The method of claim 1, wherein preoperative planning the total hip arthroplasty further includes coaxially aligning in the computer coordinate system a shaft of the three dimensional computer model of the femoral implant with a medullary canal or central axis of a shaft of the three dimensional computer model of the proximal femur.", "3.The method of claim 1, wherein computer defining the resection of the proximal femur includes defining the resection to correspond to a location of a spacer region of the three dimensional computer model of the femoral implant when the first and second centers positionally correspond in the computer coordinate system.", "4.The method of claim 1, further comprising physically registering the computer defined resection of the proximal femur with the proximal femur of the patient.", "5.The method of claim 4, further comprising computer defining a registration location on a surface of the three dimensional computer model of the proximal femur; and computer referencing the computer defined resection of the proximal femur to the computer defined registration location.", "6.The method of claim 5, wherein physically registering the computer defined resection of the proximal femur with the proximal femur of the patient further includes: physically contacting the proximal femur of the patient at a location on a surface of the proximal femur of the patient that corresponds to the computer defined registration location on the surface of the three dimensional computer model of the proximal femur.", "7.The method of claim 6, wherein physically contacting the proximal femur of the patient includes: causing a custom mating region of a jig to matingly contact the proximal femur of the patient at the location on the surface of the proximal femur of the patient that corresponds to the computer defined registration location on the surface of the three dimensional computer model of the proximal femur.", "8.The method of claim 5, wherein the computer defined registration location is on at least on a posterior neck of the three dimensional computer model of the proximal femur.", "9.The method of claim 5, wherein the computer defined registration location is on at least on a posterior neck of the three dimensional computer model of the proximal femur and a posterior greater trochanter of the three dimensional computer model of the proximal femur.", "10.The method of claim 9, wherein the computer defined registration location is not on a trochanteric fossa of the three dimensional computer model of the proximal femur.", "11.The method of claim 9, wherein the computer defined registration location is also at least on a posterior intertrochanteric crest of the three dimensional computer model of the proximal femur.", "12.The method of claim 5, wherein the computer defined registration location is at least on a posterior greater trochanter of the three dimensional computer model of the proximal femur.", "13.The method of claim 12, wherein the computer defined registration location on the posterior greater trochanter of the three dimensional computer model of the proximal femur includes a portion laterally adjacent a posterior intertrochanteric crest of the three dimensional computer model of the proximal femur.", "14.The method of claim 5, wherein the computer defined registration location is on at least on an anterior neck of the three dimensional computer model of the proximal femur.", "15.The method of claim 14, wherein the computer defined registration location is not on a superior junction between a posterior and anterior surface of a neck of the three dimensional computer model of the proximal femur.", "16.The method of claim 14, wherein the computer defined registration location is not on an inferior junction between a posterior and anterior surface of a neck of the three dimensional computer model of the proximal femur.", "17.The method of claim 5, wherein the computer defined registration location is on at least on an anterior neck of the three dimensional computer model of the proximal femur and an anterior greater trochanter of the three dimensional computer model of the proximal femur.", "18.The method of claim 17, wherein the computer defined registration location is not on a tubercle of the three dimensional computer model of the proximal femur.", "19.The method of claim 5, wherein the computer defined registration location is at least on an anterior greater trochanter of the three dimensional computer model of the proximal femur.", "20.The method of claim 19, wherein the computer defined registration location on the anterior greater trochanter of the three dimensional computer model of the proximal femur includes a portion lateral to a tubercle of the three dimensional computer model of the proximal femur." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Arthroplasty is an orthopedic surgical procedure in which a dysfunctional or arthritic joint surface is replaced, remodeled or redesigned to alleviate pain, restore range of motion or to fix physical joint damage caused by a fracture.", "Total Hip Replacement (“THR”) surgery, also known as hip arthroplasty, is a surgical procedure wherein the proximal femur, with its femoral head and neck, is removed and a prosthetic device (or stem) having a prosthetic femoral head is implanted into the femur.", "The acetabulum, or hip socket, is also replaced or modified to accept a cup.", "The cup is configured to receive the prosthetic head.", "The prosthetic device (or stem) is typically made of titanium or a titanium alloy.", "The head may be made of a biocompatible plastic, ceramic or other suitable material.", "The cup may be made of a biocompatible plastic or other suitable material.", "The prosthetic device and the cup are typically anchored to the bone with bone cement.", "Typically, in THR, the surgeon will take a number of measurements by hand or x-ray scan related to proper selection of the prosthetic device, limb length, and hip rotation.", "During surgery, after making an incision, the femur is pushed out of socket to expose the joint cavity and the deteriorated or damaged femoral head is removed.", "The femur is then prepared to receive the stem by cleaning and enlarging the hollow center portion of the bone, thereby creating a cavity that matches the shape of the implant stem.", "The top end of the femur is planed and smoothed so the stem can be inserted flush with the bone surface.", "If the head is a separate piece, the proper size is selected and attached.", "Finally, the head is seated within the cup so the joint is properly aligned and the incision is closed.", "Hand measuring techniques and x-ray scans are inaccurate and increase the error rate or potential for error in a THR, and may lead to an improperly positioned prosthetic device.", "Improper positioning of the prosthetic device can result in a change of leg length, dislocation of the hip or perforation of the femur.", "There is a need in the art for a total hip replacement surgical guide tool to aid in properly positioning the prosthetic device that reduces the potential for error and improper positioning in a THR.", "There is also a need in the art for a method of manufacturing such a surgical guide tool." ], [ "<SOH> BRIEF SUMMARY OF THE INVENTION <EOH>Disclosed herein is a tool for positioning a prosthetic device in a femur that is the subject of a total hip replacement surgery.", "In one embodiment, the tool includes an index surface and a saw slot.", "The index surface is configured to matingly receive a predetermined surface of the femur.", "The index surface and the saw slot are integrated with each other such that when the index surface matingly receives the predetermined surface of the femur, the saw slot corresponds with the resection plane of the femur.", "Disclosed herein is surgical guide tool for use in the preparation of a proximal portion of a femur for the implantation of a total hip replacement prosthetic implant, the implant including a feature configured to abut against a resection surface of the proximal femur when the implant is fully implanted in the proximal femur in a manner that generally replicates a preoperatively planned implantation for the implant.", "In one embodiment, the tool includes a mating region and a saw guide.", "When the mating region matingly contacts the proximal portion, the saw guide is aligned with a resection plane generally corresponding to the resection surface.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the at least one planar surface forms a saw slot.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of a superior-posterior region of the neck.", "The at least a portion of a superior-posterior region of the neck starts between approximately 1 mm and approximately 5 mm after a cartilage covering the head terminates distally and extending between approximately 15 mm and approximately 35 mm towards a trochanteric fossa.", "In version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the at least a portion of a superior-posterior region of the neck has an inferior border that begins approximately midway along an intertrochanteric crest and follows along the axis of the neck.", "In one version of the embodiment, the at least a portion of a superior-posterior region of the neck has a superior border between approximately 1 mm and approximately 3 mm below a junction between superior and anterior surfaces of the neck.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of a superior-posterior region of the neck.", "The at least a portion of a superior-posterior region of the neck includes a narrow band that follows along an intertrochanteric crest and has a medial-lateral width of between approximately 0.5 mm and approximately 8 mm.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the at least a portion of a superior-posterior region of the neck begins approximately midway along the intertrochanteric crest and extends at least approximately 5 mm towards a most superior tip of a posterior surface of a greater trochanter.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of a superior-anterior region of the neck.", "The at least a portion of a superior-anterior region of the neck starts between approximately 1 mm and approximately 5 mm after a cartilage covering the head terminates distally and extends between approximately 15 mm and approximately 35 mm to terminate before a tubercle.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the at least a portion of a superior-anterior region of the neck has a superior border approximately 1 mm to approximately 3 mm below a junction between superior and anterior surfaces of the neck.", "The at least a portion of a superior-anterior region of the neck may have an inferior border that is between approximately 5 mm and approximately 10 mm from the superior boarder.", "In one version of the embodiment, the at least a portion of a superior-anterior region of the neck lies on an anterior greater trochanter, distal to a tubercle, and inferior to an origin of an obturator internus.", "The at least a portion of a superior-anterior region may have a medial-lateral distance that measures between approximately 3 mm to approximately 14 mm.", "The at least a portion of a superior-anterior region may have an inferior-superior distance that measures between approximately 3 mm to approximately 10 mm.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of a superior-posterior region of the neck and at least a portion of a superior-anterior region of the neck, but does not include a junction between the superior-posterior and superior-anterior regions of the neck.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the at least a portion of the superior-posterior region of the neck includes an area that extends along the intertrochanteric chest, but does not include an area that spans portions of a trochanteric fossa.", "The at least a portion of a superior-anterior region of the neck may lay on an anterior greater trochanter, distal to a tubercle, and inferior to an origin of an obturator internus, but does not include portions of the tubercle.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of a posterior region of the neck.", "The at least a portion of the posterior region of the neck includes an area that extends towards a trochanteric fossa between approximately 15 mm and approximately 35 mm from a first point being between approximately 1 mm and approximately 5 mm distal of a distal termination of a cartilage covering the head.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the at least a portion of a posterior region of the neck has an inferior border that terminates up to approximately 5 mm superior to a border between posterior and inferior surfaces of the neck.", "In one version of the embodiment, the at least a portion of a posterior region of the neck has a superior border that terminates approximately 0 mm to approximately 5 mm posterior of a border between posterior and anterior surfaces of the neck.", "In one version of the embodiment, the at least a portion of a posterior region of the neck extends along an intertrochanteric crest from a lesser trochanter to a point near a tip of a greater trochanter.", "The at least a portion of a posterior region of the neck does not include at least one of a portion of the trochanteric fossa and a portion of posterior region of the greater trochanter.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of a posterior region of the neck.", "The at least a portion of the posterior region of the neck includes an area that includes a narrow band measuring between approximately 0.5 mm and approximately 12 mm and following along an intertrochanteric crest.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the narrow band begins approximately 0 mm to approximately 12 mm superior to a lesser trochanter.", "The narrow band may extend approximately 0 mm to approximately 18 mm inferior to a most superior tip of a posterior surface of a greater trochanter.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of a posterior region of the neck.", "The at least a portion of the posterior region of the neck includes an area that extends towards a trochanteric fossa from a first point being between approximately 1 mm and approximately 5 mm distal of a distal termination of a cartilage covering the head, but does not include an area spanning portions of the trochanteric fossa.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, The tool of claim 32 , wherein the area spanning portions of the trochanteric fossa has a width generally transverse to a femoral longitudinal axis of between approximately 0 mm and approximately 20 mm.", "In one version of the embodiment, the at least a portion of the posterior region of the neck further includes an area that includes a band following along an intertrochanteric crest, but does not include portions of a posterior greater trochanter.", "In one version of the embodiment, the portion of the posterior greater trochanter has a distally extending dimension of between approximately 0 mm and approximately 12 mm.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of an anterior region of the neck.", "The at least a portion of an anterior region of the neck extends up to approximately 8 mm laterally past an intertrochanteric line.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the surface region includes a medial surface of a greater trochanter.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of a lateral posterior greater trochanter.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the surface region further includes at least a portion of a medial posterior greater trochanter.", "The surface region may not include at least a portion of an intertrochanteric crest.", "In one version of the embodiment, the surface region further includes at least a portion of a posterior region of the neck.", "The surface region does not include at least a portion of a trochanteric fossa.", "In one version of the embodiment, the surface region further includes at least a portion of a medial posterior greater trochanter and at least a portion of a posterior region of the neck, and wherein the surface region does not include at least a portion of an intertrochanteric crest and does not include at least a portion of an trochanteric fossa.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur.", "In one embodiment, the tool includes a mating region and a saw guide.", "The mating region matingly contacts the proximal portion.", "The saw guide is generally aligned with a preoperatively planned resection plane.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "The at least one planar surface may form a saw slot.", "In one version of the embodiment, the mating region includes contact surfaces and non-contact surfaces, wherein, when the mating region matingly contacts the proximal portion, the contact surfaces matingly contact surfaces of the proximal portion opposing the contact surfaces, and the non-contact surfaces are spaced apart from surfaces of the proximal portion opposing the non-contact surfaces.", "The non-contact surfaces may be a result of an overestimation process.", "Disclosed herein is a method of manufacturing a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the method include: a) generating medical imaging data associated with the proximal portion of the femur; b) employing the imaging data to generate a three-dimensional computer-generated femur model of the proximal portion of the femur; c) providing a three-dimensional computer-generated implant model; d) providing a three-dimensional computer-generated tool model of at least a portion of at least a surgical guide tool and a surgical guide tool blank; e) superimposing the femur model and implant model; f) superimposing the tool model with the superimposed femur model and implant model; g) computer generating manufacturing instructions from data determined from step f; and h) employing the manufacturing instructions at a manufacturing machine to generate the surgical guide tool.", "In one version of the embodiment, the surgical guide tool is generated from a surgical guide tool blank.", "In one version of the embodiment, the implant model includes a shaft portion and a head portion.", "Superimposing the femur model and implant model may include: causing a center of the head of the implant model to generally coincide with a center of a head of the femur model; and causing the shaft of the implant model to generally align with a shaft of the femur model.", "In one version of the embodiment, superimposing the tool model with the superimposed femur model and implant model includes causing the superimposed location of the tool model to generally correspond to a tool position to be employed by a selected surgical approach.", "In one version of the embodiment, the method further includes providing at least one of a three-dimensional computer generated sphere model and a computer generated rod model and at least one of: superimposing the sphere model with the femur model so a center of the sphere model is caused to generally coincide with a center of a head of the femur model; and superimposing the rod model with the femur model so the rod model is caused to generally align with a shaft of the femur model.", "Superimposing the femur model and implant model may include at least one of: causing a center of the head of the implant model to generally coincide with the center of the sphere model; and causing the shaft of the implant model to generally align with the rod model.", "In one version of the embodiment, the medical imaging data is generated via at least one of MRI and CT.", "In one version of the embodiment, the manufacturing machine is at least one of a CNC machine and a SLA.", "In one version of the embodiment, the method further includes subjecting the medical imaging data to a segmentation process that determines bone contour lines and then adjusting the bone contour lines outward in locations of the bone contour lines corresponding to regions of the proximal portion of the femur that have surface topography that is unlikely to be accurately replicated during at least one of a three-dimensional computer modeling process and generating the tool via the machine.", "The surface topography may be at least one of highly varied and too small to be manufactured into the tool.", "The method may further include employing the adjusted bone contour lines to generate the three-dimensional computer-generated femur model of the proximal portion of the femur.", "The regions of the proximal portion of the femur that have surface topography that is unlikely to be accurately replicated may include at least one of a portion of a tubercle and a portion of a superior intersection between anterior and posterior regions of the neck.", "The regions of the proximal portion of the femur that have surface topography that is unlikely to be accurately replicated may include at least one of a portion of a trochanteric fossa and a portion of a superior intersection between anterior and posterior regions of the neck.", "The regions of the proximal portion of the femur that have surface topography that is unlikely to be accurately replicated may include at least one of a portion of a trochanteric fossa and a portion of a posterior greater trochanter near an intertrochanteric crest.", "The regions of the proximal portion of the femur that have surface topography that is unlikely to be accurately replicated may include at least one of a portion of a trochanteric fossa and a portion of an intertrochanteric crest.", "In one version of the embodiment, the data determined from step f includes a resection plane corresponding to a planar surface of a spacer region of the implant model.", "The data determined from step f may further include a mating surface corresponding to a region of the femur model contacted by the tool model.", "The mating surface and resection plane may be positionally referenced to each other.", "The mating surface and resection plane may be respectively used to define an indexing surface and a saw guide in the tool, the indexing surface and saw guide being configured such that, when the indexing surface matingly contacts the proximal femur, the saw guide will be positioned to facilitate a resection of the proximal femur corresponding to a preoperatively planned resection.", "While multiple embodiments are disclosed, still other embodiments of the present invention will become apparent to those skilled in the art from the following Detailed Description, which shows and describes illustrative embodiments of the invention.", "As will be realized, the invention is capable of modifications in various aspects, all without departing from the spirit and scope of the present invention.", "Accordingly, the drawings and detailed description are to be regarded as illustrative in nature and not restrictive." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS The present application is a continuation of U.S. application Ser.", "No.", "15/202,417 filed Jul.", "5, 2016, which application is a divisional of U.S. application Ser.", "No.", "12/391,008 filed Feb. 23, 2009, now U.S. Pat.", "No.", "9,408,618, which application claims benefit of priority under 35 U.S.C.", "119(e) to: U.S. Patent Application Ser.", "No.", "61/032,671, entitled Hip Resurfacing Surgical Guide Tool and filed Feb. 29, 2008; U.S. Patent Application Ser.", "No.", "61/108,761, entitled Hip Resurfacing Surgical Guide Tool and filed Oct. 27, 2008; and U.S. Patent Application Ser.", "No.", "61/111,238, entitled Total Hip Replacement Surgical Guide Tool and filed Nov. 4, 2008.The foregoing applications are hereby incorporated by reference into the present application in their entireties.", "The present application also incorporates by reference in its entirety U.S. patent application Ser.", "No.", "12/390,667, filed Feb. 23, 2009, now U.S. Pat.", "No.", "8,734,455 entitled Hip Resurfacing Surgical Guide Tool.", "FIELD OF THE INVENTION The present invention relates to medical apparatus and methods.", "More specifically, the present invention relates to total hip replacement surgical guide tools and methods of manufacturing and using such tools.", "BACKGROUND OF THE INVENTION Arthroplasty is an orthopedic surgical procedure in which a dysfunctional or arthritic joint surface is replaced, remodeled or redesigned to alleviate pain, restore range of motion or to fix physical joint damage caused by a fracture.", "Total Hip Replacement (“THR”) surgery, also known as hip arthroplasty, is a surgical procedure wherein the proximal femur, with its femoral head and neck, is removed and a prosthetic device (or stem) having a prosthetic femoral head is implanted into the femur.", "The acetabulum, or hip socket, is also replaced or modified to accept a cup.", "The cup is configured to receive the prosthetic head.", "The prosthetic device (or stem) is typically made of titanium or a titanium alloy.", "The head may be made of a biocompatible plastic, ceramic or other suitable material.", "The cup may be made of a biocompatible plastic or other suitable material.", "The prosthetic device and the cup are typically anchored to the bone with bone cement.", "Typically, in THR, the surgeon will take a number of measurements by hand or x-ray scan related to proper selection of the prosthetic device, limb length, and hip rotation.", "During surgery, after making an incision, the femur is pushed out of socket to expose the joint cavity and the deteriorated or damaged femoral head is removed.", "The femur is then prepared to receive the stem by cleaning and enlarging the hollow center portion of the bone, thereby creating a cavity that matches the shape of the implant stem.", "The top end of the femur is planed and smoothed so the stem can be inserted flush with the bone surface.", "If the head is a separate piece, the proper size is selected and attached.", "Finally, the head is seated within the cup so the joint is properly aligned and the incision is closed.", "Hand measuring techniques and x-ray scans are inaccurate and increase the error rate or potential for error in a THR, and may lead to an improperly positioned prosthetic device.", "Improper positioning of the prosthetic device can result in a change of leg length, dislocation of the hip or perforation of the femur.", "There is a need in the art for a total hip replacement surgical guide tool to aid in properly positioning the prosthetic device that reduces the potential for error and improper positioning in a THR.", "There is also a need in the art for a method of manufacturing such a surgical guide tool.", "BRIEF SUMMARY OF THE INVENTION Disclosed herein is a tool for positioning a prosthetic device in a femur that is the subject of a total hip replacement surgery.", "In one embodiment, the tool includes an index surface and a saw slot.", "The index surface is configured to matingly receive a predetermined surface of the femur.", "The index surface and the saw slot are integrated with each other such that when the index surface matingly receives the predetermined surface of the femur, the saw slot corresponds with the resection plane of the femur.", "Disclosed herein is surgical guide tool for use in the preparation of a proximal portion of a femur for the implantation of a total hip replacement prosthetic implant, the implant including a feature configured to abut against a resection surface of the proximal femur when the implant is fully implanted in the proximal femur in a manner that generally replicates a preoperatively planned implantation for the implant.", "In one embodiment, the tool includes a mating region and a saw guide.", "When the mating region matingly contacts the proximal portion, the saw guide is aligned with a resection plane generally corresponding to the resection surface.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the at least one planar surface forms a saw slot.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of a superior-posterior region of the neck.", "The at least a portion of a superior-posterior region of the neck starts between approximately 1 mm and approximately 5 mm after a cartilage covering the head terminates distally and extending between approximately 15 mm and approximately 35 mm towards a trochanteric fossa.", "In version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the at least a portion of a superior-posterior region of the neck has an inferior border that begins approximately midway along an intertrochanteric crest and follows along the axis of the neck.", "In one version of the embodiment, the at least a portion of a superior-posterior region of the neck has a superior border between approximately 1 mm and approximately 3 mm below a junction between superior and anterior surfaces of the neck.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of a superior-posterior region of the neck.", "The at least a portion of a superior-posterior region of the neck includes a narrow band that follows along an intertrochanteric crest and has a medial-lateral width of between approximately 0.5 mm and approximately 8 mm.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the at least a portion of a superior-posterior region of the neck begins approximately midway along the intertrochanteric crest and extends at least approximately 5 mm towards a most superior tip of a posterior surface of a greater trochanter.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of a superior-anterior region of the neck.", "The at least a portion of a superior-anterior region of the neck starts between approximately 1 mm and approximately 5 mm after a cartilage covering the head terminates distally and extends between approximately 15 mm and approximately 35 mm to terminate before a tubercle.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the at least a portion of a superior-anterior region of the neck has a superior border approximately 1 mm to approximately 3 mm below a junction between superior and anterior surfaces of the neck.", "The at least a portion of a superior-anterior region of the neck may have an inferior border that is between approximately 5 mm and approximately 10 mm from the superior boarder.", "In one version of the embodiment, the at least a portion of a superior-anterior region of the neck lies on an anterior greater trochanter, distal to a tubercle, and inferior to an origin of an obturator internus.", "The at least a portion of a superior-anterior region may have a medial-lateral distance that measures between approximately 3 mm to approximately 14 mm.", "The at least a portion of a superior-anterior region may have an inferior-superior distance that measures between approximately 3 mm to approximately 10 mm.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of a superior-posterior region of the neck and at least a portion of a superior-anterior region of the neck, but does not include a junction between the superior-posterior and superior-anterior regions of the neck.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the at least a portion of the superior-posterior region of the neck includes an area that extends along the intertrochanteric chest, but does not include an area that spans portions of a trochanteric fossa.", "The at least a portion of a superior-anterior region of the neck may lay on an anterior greater trochanter, distal to a tubercle, and inferior to an origin of an obturator internus, but does not include portions of the tubercle.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of a posterior region of the neck.", "The at least a portion of the posterior region of the neck includes an area that extends towards a trochanteric fossa between approximately 15 mm and approximately 35 mm from a first point being between approximately 1 mm and approximately 5 mm distal of a distal termination of a cartilage covering the head.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the at least a portion of a posterior region of the neck has an inferior border that terminates up to approximately 5 mm superior to a border between posterior and inferior surfaces of the neck.", "In one version of the embodiment, the at least a portion of a posterior region of the neck has a superior border that terminates approximately 0 mm to approximately 5 mm posterior of a border between posterior and anterior surfaces of the neck.", "In one version of the embodiment, the at least a portion of a posterior region of the neck extends along an intertrochanteric crest from a lesser trochanter to a point near a tip of a greater trochanter.", "The at least a portion of a posterior region of the neck does not include at least one of a portion of the trochanteric fossa and a portion of posterior region of the greater trochanter.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of a posterior region of the neck.", "The at least a portion of the posterior region of the neck includes an area that includes a narrow band measuring between approximately 0.5 mm and approximately 12 mm and following along an intertrochanteric crest.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the narrow band begins approximately 0 mm to approximately 12 mm superior to a lesser trochanter.", "The narrow band may extend approximately 0 mm to approximately 18 mm inferior to a most superior tip of a posterior surface of a greater trochanter.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of a posterior region of the neck.", "The at least a portion of the posterior region of the neck includes an area that extends towards a trochanteric fossa from a first point being between approximately 1 mm and approximately 5 mm distal of a distal termination of a cartilage covering the head, but does not include an area spanning portions of the trochanteric fossa.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, The tool of claim 32, wherein the area spanning portions of the trochanteric fossa has a width generally transverse to a femoral longitudinal axis of between approximately 0 mm and approximately 20 mm.", "In one version of the embodiment, the at least a portion of the posterior region of the neck further includes an area that includes a band following along an intertrochanteric crest, but does not include portions of a posterior greater trochanter.", "In one version of the embodiment, the portion of the posterior greater trochanter has a distally extending dimension of between approximately 0 mm and approximately 12 mm.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of an anterior region of the neck.", "The at least a portion of an anterior region of the neck extends up to approximately 8 mm laterally past an intertrochanteric line.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the surface region includes a medial surface of a greater trochanter.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the tool includes a body including a saw guide and a mating region configured to matingly contact the surface region.", "The saw guide and mating region are positioned relative to each other so the saw guide is positioned to guide a resection that generally corresponds to a preoperatively planned resection plane when the mating region matingly contacts the surface region.", "The surface region includes at least a portion of a lateral posterior greater trochanter.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "In one version of the embodiment, the surface region further includes at least a portion of a medial posterior greater trochanter.", "The surface region may not include at least a portion of an intertrochanteric crest.", "In one version of the embodiment, the surface region further includes at least a portion of a posterior region of the neck.", "The surface region does not include at least a portion of a trochanteric fossa.", "In one version of the embodiment, the surface region further includes at least a portion of a medial posterior greater trochanter and at least a portion of a posterior region of the neck, and wherein the surface region does not include at least a portion of an intertrochanteric crest and does not include at least a portion of an trochanteric fossa.", "Disclosed herein is a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur.", "In one embodiment, the tool includes a mating region and a saw guide.", "The mating region matingly contacts the proximal portion.", "The saw guide is generally aligned with a preoperatively planned resection plane.", "In one version of the embodiment, the saw guide includes at least one planar surface.", "The at least one planar surface may form a saw slot.", "In one version of the embodiment, the mating region includes contact surfaces and non-contact surfaces, wherein, when the mating region matingly contacts the proximal portion, the contact surfaces matingly contact surfaces of the proximal portion opposing the contact surfaces, and the non-contact surfaces are spaced apart from surfaces of the proximal portion opposing the non-contact surfaces.", "The non-contact surfaces may be a result of an overestimation process.", "Disclosed herein is a method of manufacturing a surgical guide tool for use in total hip replacement surgery on a proximal portion of a femur having a head, a neck extending distally from the head, and a surface region distal the head.", "In one embodiment, the method include: a) generating medical imaging data associated with the proximal portion of the femur; b) employing the imaging data to generate a three-dimensional computer-generated femur model of the proximal portion of the femur; c) providing a three-dimensional computer-generated implant model; d) providing a three-dimensional computer-generated tool model of at least a portion of at least a surgical guide tool and a surgical guide tool blank; e) superimposing the femur model and implant model; f) superimposing the tool model with the superimposed femur model and implant model; g) computer generating manufacturing instructions from data determined from step f; and h) employing the manufacturing instructions at a manufacturing machine to generate the surgical guide tool.", "In one version of the embodiment, the surgical guide tool is generated from a surgical guide tool blank.", "In one version of the embodiment, the implant model includes a shaft portion and a head portion.", "Superimposing the femur model and implant model may include: causing a center of the head of the implant model to generally coincide with a center of a head of the femur model; and causing the shaft of the implant model to generally align with a shaft of the femur model.", "In one version of the embodiment, superimposing the tool model with the superimposed femur model and implant model includes causing the superimposed location of the tool model to generally correspond to a tool position to be employed by a selected surgical approach.", "In one version of the embodiment, the method further includes providing at least one of a three-dimensional computer generated sphere model and a computer generated rod model and at least one of: superimposing the sphere model with the femur model so a center of the sphere model is caused to generally coincide with a center of a head of the femur model; and superimposing the rod model with the femur model so the rod model is caused to generally align with a shaft of the femur model.", "Superimposing the femur model and implant model may include at least one of: causing a center of the head of the implant model to generally coincide with the center of the sphere model; and causing the shaft of the implant model to generally align with the rod model.", "In one version of the embodiment, the medical imaging data is generated via at least one of MRI and CT.", "In one version of the embodiment, the manufacturing machine is at least one of a CNC machine and a SLA.", "In one version of the embodiment, the method further includes subjecting the medical imaging data to a segmentation process that determines bone contour lines and then adjusting the bone contour lines outward in locations of the bone contour lines corresponding to regions of the proximal portion of the femur that have surface topography that is unlikely to be accurately replicated during at least one of a three-dimensional computer modeling process and generating the tool via the machine.", "The surface topography may be at least one of highly varied and too small to be manufactured into the tool.", "The method may further include employing the adjusted bone contour lines to generate the three-dimensional computer-generated femur model of the proximal portion of the femur.", "The regions of the proximal portion of the femur that have surface topography that is unlikely to be accurately replicated may include at least one of a portion of a tubercle and a portion of a superior intersection between anterior and posterior regions of the neck.", "The regions of the proximal portion of the femur that have surface topography that is unlikely to be accurately replicated may include at least one of a portion of a trochanteric fossa and a portion of a superior intersection between anterior and posterior regions of the neck.", "The regions of the proximal portion of the femur that have surface topography that is unlikely to be accurately replicated may include at least one of a portion of a trochanteric fossa and a portion of a posterior greater trochanter near an intertrochanteric crest.", "The regions of the proximal portion of the femur that have surface topography that is unlikely to be accurately replicated may include at least one of a portion of a trochanteric fossa and a portion of an intertrochanteric crest.", "In one version of the embodiment, the data determined from step f includes a resection plane corresponding to a planar surface of a spacer region of the implant model.", "The data determined from step f may further include a mating surface corresponding to a region of the femur model contacted by the tool model.", "The mating surface and resection plane may be positionally referenced to each other.", "The mating surface and resection plane may be respectively used to define an indexing surface and a saw guide in the tool, the indexing surface and saw guide being configured such that, when the indexing surface matingly contacts the proximal femur, the saw guide will be positioned to facilitate a resection of the proximal femur corresponding to a preoperatively planned resection.", "While multiple embodiments are disclosed, still other embodiments of the present invention will become apparent to those skilled in the art from the following Detailed Description, which shows and describes illustrative embodiments of the invention.", "As will be realized, the invention is capable of modifications in various aspects, all without departing from the spirit and scope of the present invention.", "Accordingly, the drawings and detailed description are to be regarded as illustrative in nature and not restrictive.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1A is a diagrammatic depiction of a system for preoperatively planning and manufacturing a surgical guide tool as described herein.", "FIG.", "1B is a diagrammatic depiction of the preoperative planning process, beginning with the generation of the 2D medical images and ending with the manufacturing instructions being sent to the CNC machine.", "FIG.", "1C is a flow chart extending from the generation of the 2D medical images, through the preoperative planning and manufacturing of the tool, and finishing with the tool being employed in the arthroplasty procedure.", "FIG.", "2A is an isometric view of a surgical guide tool matingly engaged with a proximal femur having a femoral head and neck.", "FIG.", "2B is a side top isometric view of the surgical guide tool of FIG.", "2A, wherein the tool is in a non-customized state or is in the form of a blank from which a customized tool is generated via an automated manufacturing machine, such as, for example, a CNC milling machine.", "FIG.", "2C is a front view of the surgical guide tool of FIG.", "2B.", "FIG.", "2D is a side view of the surgical guide tool of FIG.", "2B.", "FIG.", "2E is a top plan view of the surgical guide tool of FIG.", "2B.", "FIG.", "2F is the same view as FIG.", "2B, except the tool is in the customized state depicted in FIG.", "2A and a saw slot is shown.", "FIG.", "2G is a side bottom isometric view of a version of the tool depicted in FIG.", "2F, except the tool of FIG.", "2G employs a planar surface as the saw guide in place of the saw slot depicted in FIG.", "2F, the mating region of the tool of FIG.", "2G being configured to engage the mating region of the femur depicted in FIG.", "13.FIG.", "2H is a cross section taken through section line 2H-2H, which extends generally posterior-anterior in FIG.", "2A, except employing the version of the tool depicted in FIG.", "2G.", "FIG.", "2I is a view similar to FIG.", "2G, except of a tool with a mating region configured to matingly engage the mating region of the femur depicted in FIGS.", "14A-14B.", "FIG.", "2J is the same view as 2G, except of a tool with a mating region configured to matingly engage the mating region of the femur depicted in FIG.", "15.FIG.", "3 is a posterior view of a 3D computer generated model of the proximal femur, including its femoral head, neck and greater trochanter, illustrating the angle Z at which the bone scan is sectioned.", "FIG.", "4A is a 3D view of the proximal femur of FIG.", "2A, illustrating a section line A at which the bone is sectioned during a CT scan to help create a cortical bone model and trabecular bone model.", "FIG.", "4B is a CT slice as taken along section line A of FIG.", "2A.", "FIG.", "5A is a 3D view of the proximal femur of FIG.", "2A, illustrating a section line B at which the bone is sectioned during a CT scan to help create a cortical bone model and trabecular bone model.", "FIG.", "5B is a CT slice as taken along section line B of FIG.", "5A.", "FIG.", "6A is a 3D view of the proximal femur of FIG.", "2A, illustrating a section line C at which the bone is sectioned during a CT scan to help create a cortical bone model and trabecular bone model.", "FIG.", "6B is a CT slice as taken along section line C of FIG.", "6A.", "FIG.", "7 is an example superior view CT scan of the proximal femur, wherein the correct coronal alignment for CT reconstruction is shown.", "FIG.", "8 is an example CT scan of the proximal femur, wherein the correct alignment for the final CT reconstruction is shown.", "FIG.", "9A is a transparent posterior view of a model of the proximal femur of FIG.", "2A, wherein a sphere model and a rod model are shown.", "FIG.", "9B is a transparent superior view of the models depicted in FIG.", "9A.", "FIG.", "9C is the same view as FIG.", "9A, except a femoral component model is also shown.", "FIG.", "10 is an isometric posterior view of a model of the femur of FIG.", "2A, wherein the surgical guide tool blank model is shown positioned on the femur.", "FIG.", "11 is an isometric inferior-posterior view of the model of the femur and the surgical guide tool blank model, wherein the distal end of the tool model is highlighted to illustrate a portion of the tool that may be removed for proper exposure of the greater trochanter.", "FIG.", "12 is a transparent view of the femoral component model, model of the femur, and the model of the customized surgical guide tool properly superimposed relative to each other.", "FIG.", "13 is a posterior medial view of the proximal femur of FIG.", "2A showing the regions of the femur that are mated with the index surfaces of an embodiment of the tool and the regions that correspond to over-estimated or non-contacting surfaces of the tool.", "FIGS.", "14A-14B are, respectively, posterior and anterior views of the proximal femur, wherein the mating region of the femur may be appropriate for a posterior or anteriorlateral surgical approach.", "FIG.", "15 is an isometric posterior view of the proximal femur and illustrates yet another mating region of the femur that may be used to define the mating region of another embodiment of the tool configured for a posterior surgical approach.", "FIGS.", "16A-16B are, respectively, posterior and anterior views of the proximal femur, wherein the mating region of the femur may be appropriate for a posterior or anteriorlateral surgical approach.", "DETAILED DESCRIPTION I. Overview of Tool and Its Methods of Planning, Manufacturing and Use The present disclosure describes a customized surgical guide tool 5 for use in total hip replacement surgery (“THR”).", "In one embodiment, the customized surgical guide tool 5 may be preoperatively planned via three-dimensional (“3D”) computer modeling procedures such that, when the tool 5 is matingly engaged with the proximal femur 40 of the patient, a resection guided by the tool 5 will result in a desired resection that will allow a femoral prosthetic implant or component 800 to be implanted in the femur 40 as planned during the preoperative planning.", "In one embodiment, the tool 5 may include a single-piece construction, a fastener receiving feature 1710, a customized saw guide 1725, and a customized indexing or mating region 20 having customized indexing or mating surfaces 708a, 710a.", "The fastener receiving feature 1710 may be used to receive an anchor that may secure the tool 5 in mating engagement with the proximal femur 40.The mating region 20 and its mating surfaces 708a, 710a may be configured such that, when the mating region 20 matingly receives therein a region of the proximal femur 40 having predetermined bone surfaces 708, 710, the mating surfaces 708a, 710a of the mating region 20 of the tool 5 will matingly contact the predetermined bone surfaces 708, 710 on the proximal femur 40.The mating region 20 may also include non-contacting surfaces 718a, 720a that correspond to surfaces of proximal femur 40 that are within the region of the femur engaged by the tool mating region 20 and that have surface topography of such variation that it is difficult to accurately scan or computer model or too small to manufacture into the tool mating region.", "These non-contacting surfaces 718a, 720a of the tool mating region 20 may be the result of an overestimation process during image segmentation and will be spaced apart in a non-contacting fashion from the adjacent femur surfaces when the tool mating region 20 matingly receives the femur 40.The saw guide 1725 may be a slot, planar surface, or other feature capable of guiding a saw blade during a sawing procedure.", "The saw guide 1725 may be positioned and oriented relative to the customized mating or indexing region 20 such that, when the mating surfaces 708a, 710a of the mating region 20 matingly contact the bone surfaces 708, 710 when the tool mating region 20 matingly receives therein the region of the femur 40 having the bone surfaces 708, 710, the saw guide 1725 may be oriented over the femur neck 35 such that the saw guide 1725 corresponds with a desired resection plane 805 through the femoral neck 35 that was identified during the preoperative planning.", "The resection plane 805 may correspond with a spacer region 801 of the femoral prosthetic implant or component 800 that limits the extent to which the femoral component may be inserted into the resected proximal femur during implantation.", "When the mating or indexing surfaces 708a, 710a of the mating region 20 of the tool 5 matingly contact the bone surfaces 708, 710 as the mating region 20 mating receives the region of the femur including the bone surfaces 708, 710, a saw extending through the saw slot 1725 will be caused to saw through the femur neck 35 at the desired and preoperatively planned resection plane 805, thereby creating a resected portion of the neck 35 that is configured to receive an implanted femoral component 800 in a manner that replicates the preoperatively planned implant position and alignment.", "Once the femur resection is completed with the tool 5 and the femur is further prepped as needed, the femoral component 800, which may be selected based on the information obtained during the preoperative planning, may then be inserted into the resected proximal femur 40.As stated above, in some embodiments, the tool 5 may have a single-piece construction, which may increase the accuracy associated with the resectioning process by minimizing tolerance errors normally associated with multi-piece, multi-joint, conventional guide tools.", "In other embodiments, the tool 5 may have a multi-piece construction.", "For example, the saw slot 1725 may be in the form of a separate guide that is mounted on the rest of the tool 5 in an indexed manner, the rest of the tool 5 having the customized mating region having the customized mating surfaces.", "The guide tool 5 aids the surgeon in accurately implanting the femoral component 800 during a THR according to an alignment and position determined during preoperative planning.", "Specifically, the tool 5, once matingly engaged with the proximal femur, may guide the resection of the proximal femur according to a resection plane identified during the preoperative planning.", "Accurate implant alignment and position is important because an improperly positioned and aligned femoral component 800 may result in a change of leg length, dislocation of the hip or perforation of the femur.", "Furthermore, because the tool 5 is configured to generally automatically provide an appropriate resection through the femur neck for a proper alignment of the femoral component upon causing the indexing region 20 to matingly receive the region of the femur having the bone surfaces 708, 710, the time and effort required by the surgeon to properly prepare the femur for the implantation of the femoral component 800 is substantially minimized.", "Thus, use of the tool 5 may reduce the overall time spent in surgery.", "The reduction in the time spent in surgery may reduce the patient's chances of infection.", "In some embodiments, a three dimensional (“3D”) model of the patient's proximal femur 40 is computer generated from two dimensional (“2D”) medical imaging slices 500 (e.g., CT slices, MRI slices, etc.)", "taken of the patient's proximal femur 40.A sphere 3D computer model 701 and a rod 3D computer model 702 may be respectively aligned with the femoral head 30 and medullary canal 170 or the central axis 100 of the femur shaft of the femur 3D computer model 1040 to approximate the positioning of the femoral component 800 relative to the center of the hip joint 703.A 3D model of the femoral component 800 may be selected from a database of 3D models of candidate femoral component 800.The selected 3D model of the femoral component may be aligned with the 3D model of the femur 40 and the sphere and rod models 701, 702 such that the component head is generally centered with the center of the sphere model and the component shaft is generally coaxial with the rod model.", "A 3D model of a blank of the tool 5 may be positioned on the femur model, which is still aligned with the sphere, rod and femoral component models 701, 702, 800.The resection plane may be determined from the location of a spacer region surface or distal end 803 of a spacer region 801 of the femoral component 800 and used to define a saw slot 1725 in the 3D model of the blank of the tool 5.The 3D model of the femur is analyzed to determine shape and location of the mating or indexing femur surfaces 708, 710.The shape and location of the surfaces 708, 710 may be used to define corresponding mating surfaces 708a, 710a in the mating region 20 of the 3D model of the blank of the tool 5.The indexing surfaces 708a, 710a of the mating region 20, the saw slot 1725, and the orientation relationships between the surfaces 708a, 710a and the saw slot 1725 may be imported into the 3D computer generated model of the blank of the tool 5.As the 3D femur model, 3D sphere model, 3D rod model and 3D tool blank model are superimposed relative to each other in the above-described orientation and positioning, the surfaces 708a, 710a and saw slot 1725 end up being defined and imported into the 3D tool blank model such that a resulting tool 5 will position the saw slot 1725 to create the preoperatively planned resection in the femur when the mating surfaces 708a, 710a of the mating region 20 matingly contact the femur surfaces 708, 710 when the mating region 20 matingly receives the region of the femur having the femur surfaces 708, 710.The resulting 3D model of the blank of the tool 5 may be used to generate manufacturing instructions (e.g., machining paths, etc.", "), which are sent to an automated manufacturing device, such as a CNC machine, a stereolithography apparatus (“SLA”), etc.", "to mill or otherwise manufacture an actual tool 5 from an actual tool blank 50.As can be understood from the preceding discussion and as discussed in greater detail below, by superimposing a 3D computer generated model of the patient's proximal femur 40 with the 3D computer generated models of the femoral component 800, sphere, and rod, the proper placement and alignment of the femoral component 800 through the proximal femur 40 can be preoperatively planned with a great degree of accuracy.", "Also, by superimposing the 3D computer generated model of the blank of the tool 5 with the superimposed 3D computer generated models of the patient's femur 40 and the femoral component 800, the relationships between these models can be analyzed to determine the location and orientation of the saw guide 1725, the location and shape of the indexing surfaces 708a, 710a of the mating region 20, and the positional relationship between the saw guide 1725 and indexing surfaces 708a, 710a, all of which can be imported into the 3D computer generated model of the blank of the tool 5 to define such features into the 3D model of the tool blank.", "The resulting 3D computer generated model of the blank of the tool 5 may then be used as manufacturing instructions for the automated manufacture of a customized guide tool 5 having a saw guide 1725 that will result in the preoperatively planned resection of the proximal femur 40 when the tool 5 is matingly engaged with the proximal femur such that the indexing surfaces 708a, 710a mating contact the predetermined femur surfaces 708, 710 when the tool mating region matingly receives the proximal femur 40.Thus, the resulting tool 5 is customized for the specific patient via a preoperative planning process that employs a 3D model of the patient's femur compiled from 2D medical images 500 taken of the patient's femur.", "The resulting tool 5 includes the “data” physically integrated therein that allows the tool 5 to matingly engage the patient femur 40 and direct the resection of the femur as calculated during the preoperative planning process to facilitate a desired preoperatively planned position and orientation of the implanted femur component 800.II.", "Total Hip Replacement Surgical Guide Tool For a detailed discussion of an embodiment of the surgical guide tool 5 for use in a total hip replacement surgery, reference is made to FIGS.", "2A-2H.", "FIG.", "2A is an isometric view of a surgical guide tool 5 matingly engaged on a proximal femur 40 having a femoral head 30 and neck 35.FIG.", "2B is a side top isometric view of the surgical guide tool 5 of FIG.", "2A, wherein the tool 5 is in a non-customized state or is in the form of a blank from which a customized tool 5 is generated via an automated manufacturing machine, such as, for example, a CNC milling machine.", "FIGS.", "2C-2E are front, side and top plan views, respectively, of the tool 5 of FIG.", "2B.", "FIG.", "2F is the same view as FIG.", "2B, except the tool 5 is in the customized state depicted in FIG.", "2A and a saw slot 1725 is shown.", "FIG.", "2G is a side bottom isometric view of a version of the tool 5 depicted in FIG.", "2F, except the tool 5 of FIG.", "2G employs a planar surface 1725 as the saw guide 1725 in place of the saw slot 1725 depicted in FIG.", "2F, the mating region 20 of the tool 5 of FIG.", "2G being configured to engage the mating region of the femur 40 depicted in FIG.", "13.FIG.", "2H is a cross section taken through section line 2H-2H, which extends generally posterior-anterior in FIG.", "2A, except employing the version of the tool 5 depicted in FIG.", "2G.", "As illustrated in FIGS.", "2A-2H, in one embodiment, the surgical guide tool 5 includes a proximal or head end 1745, a distal or greater trochanter end 1750, a top side 1755 and a bottom side 1760.As can be understood from FIGS.", "2B-2E, in a non-customized state, the bottom side 1760 and the top side 1755 are generally arcuately shaped.", "As shown in FIG.", "2E, in one embodiment, the width of the tool 5 may gradually increase from the proximal end 1745 to the distal end 1750.The ends 1745, 1750 are formed or otherwise joined together via the bottom side 1760 and top side 1755 such that the tool 5 may be a single-piece tool having a single-piece construction that is generally unitary and continuous in nature.", "In other embodiments, the tool 5 may have a multi-piece construction, for example, where the saw guide is mounted as a separate and independent piece on the rest of the tool that includes the mating region.", "The tool 5 may be made of polyoxymethylene (acetal resin), a low density polyethylene, or other biocompatible plastics.", "As can be understood from FIGS.", "2F-2H, portions of the bottom side 1760 and the top side 1755 may include a customizable mating or indexing region 20 that may have mating contact surfaces 708a, 710a and non-contacting surfaces 718a, 720a defined therein.", "The mating or indexing region 20 may be adapted to matingly receive regions of the proximal femur 40 having mating contact surfaces 708, 710 and non-contacting surfaces 718, 720 such as those discussed in detail later this Detailed Description with respect to FIG.", "13 or similar to those discussed in detail with respect to FIGS.", "14A-16B.", "For example, as can be understood from FIGS.", "2A, 2G, 2H and 13, the region of the femur 40, which may be matingly received by the tool mating region 20 when the tool 5 is mounted on the femur 40, may include a mating contact surface 708 covering portions of the posterior region of the neck 35 and a mating contact surface 710 that is a narrow band following along the intertrochanteric crest 116.Since the tool 5 is customized to fit the patient's specific bone geometry, the mating contact surfaces 708a, 710a of the tool mating region 20 may be configured to matingly contact the mating contact surfaces 708, 710 of the femur 40 when the tool mating region 20 matingly receives therein the region of the femur that has the mating contact surfaces 708, 710.The femur surfaces 708, 710 to be mated or indexed by the tool mating or index surfaces 708a, 710a may be separated by non-contacting surfaces 718, 720 of the femur 40.The non-contacting surfaces 718, 720 of the femur 40 may be spanned in a spaced-apart, non-contacting arrangement by non-contacting surfaces 718a, 720a of the tool mating region 20 when the tool mating region 20 matingly receives the region of the femur 40 including the non-contacting surfaces 718, 720 and the tool mating surfaces 708a, 710a matingly contact the femur contacting surfaces 708, 710.The non-contacting surfaces 718a, 720a of the tool mating region 20 may be the result of an over-estimating process occurring during image segmentation as described later in this Detailed Description.", "As can be understood from FIG.", "13, the non-mating surfaces 718, 720 of the proximal femur 40 may include portions 718 of the posterior greater trochanter 115 and portions 720 of the trochanteric fossa 210 (i.e., the depression between the greater trochanter and the femur neck).", "As shown in FIGS.", "2B-2E, the top side 1755 may include a fastener-receiving feature 1710.The fastener-receiving feature 1710 may be generally ring shaped and may include a hole 1715 extending axially therethrough.", "In one embodiment, the top side 1755 includes one fastener-receiving feature 1710.In some embodiments, the top side 1755 includes more than one fastener-receiving feature 1710.The fastener receiving feature 1710 is configured to receive a fastener 1716 through the hole 1715, thereby securing the tool 5 to the femur 40 when the indexing surfaces 708a, 710a of the tool mating region 20 matingly contact the corresponding bone surfaces 708, 710.In some embodiments, the top face does not include a fastener receiving feature 1710 and the tool is secured by other methods, such as being held in place by the surgeon.", "The fastener 1716 may be a pin, screw or other suitable device.", "As can be understood from FIGS.", "2F and 2G, in a customized state, the top side 1755 may also include a saw guide 1725 that is configured to receive a saw blade during a THR.", "The saw guide 1725 may be in the form of a planar surface, a slot or any other feature capable of guiding a saw during a resection.", "In one embodiment, the saw slot 1725 is generally an open-ended rectangle and extends axially through the tool 5 from the top side 1755 to the bottom side 1760.In some embodiments, the saw slot 1725 may extend across the entire width of the neck 35 such that the surgeon may make a complete resection of the neck.", "In some embodiments, the saw slot 1725 may extend at least partially across the width of the neck such that the surgeon may make a partial neck resection.", "As will be discussed in more detail below with respect to FIG.", "12, the saw slot 1725 may be positioned in the tool 5 such that the slot 1725 is aligned with a preoperatively planned resection plane 805, as determined by 3D modeling.", "The resection plane 805 may correspond with a spacer region 801 of the femoral prosthetic implant or component 800 that limits the extent to which the femoral component may be inserted into the resected proximal femur during implantation.", "The resection plane 805 defines the location of the head and neck resection during surgery.", "Thus, when a saw blade is inserted into the saw slot 1725, the subsequent cut through the neck 35 of the proximal femur 40 will expose a portion of the neck 35 for receipt of the femoral component 800.Because the location of the saw slot 1725 is determined based on preoperative planning employing 3D models of the patient's femur and the specific implant 800 to employed in the THR, the subsequent cut through the neck is positioned to expose a portion of the neck aligned to receive the femoral component 800 such that the femoral component 800 may be accurately positioned upon insertion into the femur.", "III.", "System for Planning and Manufacture of Tool The above-described customized guide tool 5 may be designed and manufactured employing a system 4 similar to that schematically depicted in FIG.", "1A.", "As shown in FIG.", "1A, the system 4 may include a preoperative planning system 6 in the form of a computer 6 having a CPU 7, a monitor or screen 9 and operator interface controls 11, such as a keyboard, mouse, etc.", "The computer 6 may be linked to a medical imaging system 8, such as a CT or MRI machine 8, and an automated or rapid manufacturing machine 10, such as a stereolithography apparatus (“SLA”) or a computer numerical controlled (“CNC”) milling machine 10.The imaging machine 8, the manufacturing machine 10, and the modeling system 6 of the system 4 may be in communication with each other via, for example, hardwire, internet, wireless, portable memory devices or any combination thereof.", "The medical imaging machine 8 may be employed to generate medical images 500 of the joint 14 of the patient 12 that is the subject of the arthroplasty.", "While this Detailed Description is given in the context of the joint 14 being a hip joint 14 and the tool 5 being configured for the preparation of the proximal femur 40 to receive a total hip replacement prosthetic implant, the concepts disclosed herein may be readily applicable to arthroplasty for other types of joints, including, for example, ankles, knees, wrists, elbows, shoulders, vertebra, fingers, toes, etc.", "Any resulting 2D medical images 500 may be sent to the computer 6 for use in the preoperative planning.", "During preoperative planning, an operator may view the various 3D computer generated models, such as the femur model 1040 and others, via the monitor 11 as the operator interacts with the computer 6 via the controls 11 to direct the preoperative planning.", "Computer programs for creating, storing and manipulating the various 3D computer generated models may be stored in computer memory accessible by the CPU 7.Computer programs for creating the 3D computer generated bone model 1040 from the 2D images 500 include: Analyze from AnalyzeDirect, Inc., Overland Park, Kans.", "; Insight Toolkit, an open-source software available from the National Library of Medicine Insight Segmentation and Registration Toolkit (“ITK”), www.itk.org; 3D Slicer, an open-source software available from www.slicer.org; Mimics from Materialise, Ann Arbor, Mich.; and Paraview available at www.paraview.org.", "Once the preoperative planning is completed, the resulting information is used to create manufacturing instructions that are sent to the automated manufacturing machine 10 to generate the final tool 5, which in some embodiments, may be manufactured from a tool blank 50 placed in the manufacturing machine 10.IV.", "Medical Imaging, Image Segmentation and Generation of 3D Bone Model For a detailed discussion regarding the medical imaging and image segmentation processes, reference is now made to FIGS.", "1A-1C.", "FIG.", "1B is a diagrammatic depiction of the tool planning process, beginning with the generation of the 2D medical images 500 and ending with the manufacturing instructions being sent to the CNC machine 10.FIG.", "1C is a flow chart extending from the generation of the 2D medical images 500, through the planning and manufacturing of the tool 5, and finishing with the tool 5 being employed in the arthroplasty procedure.", "As indicated in FIGS.", "1A-1C, a patient 12 has a hip joint 14 that is the subject of a THR surgery.", "The hip joint 14 of the patient 12 is scanned in the imaging machine 8 [block 1500 and block 1600].", "In one embodiment, the scanning may include up to one-third of the proximal femur 40, including the femoral head 30 and the lesser trochanter 740.In other embodiments, the scanning may include a greater or lesser portion of the femur.", "The resolution of a CT scan or an MRI scan is greater than the resolution of x-ray.", "Greater resolution leads to more accuracy in the preoperative planning process, which leads to greater precision in the resulting tool 5.In some embodiments, the resolution of the scan is between approximately 0 mm and approximately 2 mm.", "In other embodiments, the resolution of the scan is between approximately 0.3 mm and approximately 0.6 mm.", "In one embodiment, a CT scan with a resolution of approximately 0.6 mm is utilized for creation of the tool.", "In one embodiment, a CT scan with a resolution of approximately 0.5 mm to 2 mm, with a tube current ranging from 200 mA to 400 mA and a tube voltage ranging from 120 kV to 140 kV and a direct field of view (“DFOV”) ranging from approximately 16 cm to approximately 26 cm is utilized for creation of the tool.", "As indicated in FIGS.", "1A-1C, in performing the scanning process, the imaging machine 8 makes a plurality of scans of the joint 14, wherein each scan pertains to a thin 2D image slice 500 of the joint 14.The plurality of 2D images 500, which may be CT, MRI or other 2D medical images, are sent from the imaging machine 8 to the preoperative planning system 6.The 2D images are subjected to an image segmentation process, wherein the bone contour lines 502 are identified in each of the images 500 [block 1500 and block 1602].", "In one embodiment, the bone surface contour lines of the femur 40 depicted in the image slices 500 may be auto segmented via a image segmentation process as disclosed in U.S. Patent Application Ser.", "No.", "61/126,102, which was filed Apr.", "30, 2008, is entitled System and Method for Image Segmentation in Generating Computer Models of a Joint to Undergo Arthroplasty, and is hereby incorporated by reference into the present application in its entirety.", "As can be understood from FIG.", "3, which is a posterior view of a 3D computer generated model of the proximal femur 40, including its femoral head 30, neck 35 and greater trochanter 115, the bone scan may be sectioned for the segmentation process at an angle Z.", "In other words, in one embodiment, image segmentation is performed utilizing image slices or sections 500 at an angle Z off the central axis 100 of the femoral neck 35 viewed posteriorly.", "The segmentation can be done in several ways and for ease of the reader are described in relation to a CT-scan.", "For example, the during the CT scanning of the femur, the CT locator could be positioned at an angle Z to section the CT scan.", "Alternatively or additionally, the CT scan could be sectioned at an angle Z during post-processing.", "In one embodiment, the angle Z is between approximately thirty degrees and approximately sixty degrees.", "In an alternative embodiment, the angle Z is approximately a 45 degree angle.", "It can be appreciated that segmentation of an MRI scan may be achieved in a similar manner.", "For a discussion of the bone contour lines that may be identified during the image segmentation process, reference is made to FIGS.", "4A-6B.", "FIGS.", "4A, 5A and 6A are 3D views of the proximal femur 40 respectively showing section or scan planes A, B and C extending through the femur 40.FIGS.", "4B, 5B and 6B are respectively the segmented image slices of planes A, B and C, respectively.", "As indicated in FIG.", "4A, section or scan plane A extends through the proximal femur generally transverse to the femoral axis and just distal of the lesser trochanter.", "As shown in the resulting segmented image slice depicted in FIG.", "4B, the contour line 601 corresponding to the cortical bone and the contour line 602 corresponding to the trabecular bone 602 may be identified.", "As indicated in FIG.", "5A, section or scan plane B extends through the proximal femur generally transverse to the femoral axis and approximately midway between the tip of the greater trochanter and the lesser trochanter.", "As shown in the resulting segmented image slice depicted in FIG.", "5B, the contour line 601 corresponding to the cortical bone and the contour line 602 corresponding to the trabecular bone 602 may be identified.", "As indicated in FIG.", "6A, section or scan plane C extends through the proximal femur generally transverse to the femoral axis and just distal the tip of the greater trochanter.", "As shown in the resulting segmented image slice depicted in FIG.", "6B, the contour line 601 corresponding to the cortical bone and the contour line 602 corresponding to the trabecular bone 602 may be identified.", "In one embodiment, as can be understood from FIG.", "13, the region of the femur 40, which may be matingly received by the tool mating region 20 when the tool 5 is mounted on the femur 40, may include a mating contact surface 708 covering portions of the posterior region of the neck 35 and a mating contact surface 710 that is a narrow band following along the intertrochanteric crest 116.The femur mating contact surfaces 708, 710 may be separated by non-contacting surfaces 718, 720 of the femur 40.The non-contacting surfaces 718, 720 of the proximal femur 40 may include portions 718 of the posterior greater trochanter 115 and portions 720 of the trochanteric fossa 210.As can be understood from FIGS.", "5A, 6A and 13, the portions 708P, 710P of the cortical bone contour lines 601 in FIGS.", "5B and 6B correspond to the mating contact surfaces 708, 710 of the femur 40, and the portions 718P, 720P of the cortical bone contour lines 601 in FIGS.", "5B and 6B correspond to the non-contact surfaces 718, 720 of the femur 40.As can be understood from FIGS.", "4A and 13, the cortical contour line 601 depicted in FIG.", "4B is from a slice that would be located below the tool mating regions of the femur 40.Therefore, this contour line 601 depicted in FIG.", "4B does not have portions 718P, 720P, 708P, 710P.", "p As can be understood from FIGS.", "5B, 6B and 13, the non-contact portions 718P, 720P of the cortical bone contour lines 601 correspond to surfaces 718, 720 of the femur 40 that are difficult to replicate in the tool mating region 20 due to the extreme variance in surface topography for the surfaces 718, 720.In addition to the difficult to replicate surfaces 718, 720 depicted in FIG.", "13, other difficult to replicate surfaces that surfaces portions 718P, 720P may correspond to may include surfaces of osteophytes or other bone surface irregularities.", "The surface topography variance for the surfaces 718, 720, the osteophytes, etc.", "may be such that: (1) corresponding regions of the tool mating region 20 would be difficult to machine to correspond to the surfaces 718, 720 of the femur 40 due to limitations in the milling process; or (2) the surfaces 718, 720 would be difficult to model because of limitations in the scanning or 3D computer modeling processes.", "The difficult to replicate contour line portions 718P, 720P may be subjected to an overestimation process.", "Specifically, the difficult to replicate contour line portions 718P, 720P are modified to be extended outwardly away from the interior of the bone (i.e., over-estimated) and, in some instances smoothed with respect to shape.", "The resulting cortical bone contour lines 601 now include the original portions 708P, 710P in their original shape and location and the now overestimated or outwardly adjusted portions 718P, 720P; these resulting cortical bone contour lines 601 from each image slice are then compiled or reconstructed into the 3D computer generated femur model 1040 used for the preoperative planning process.", "The end result of the overestimation process with respect to the manufacture of the completed tool 5 is that the CNC tool paths corresponding to the overestimated regions of the femur model 1040 remove excess materials from the mating region 20 of the blank used to form the tool 5.Accordingly, the tool mating region 20 is configured to matingly contact only with those surfaces 708, 710 of the femur that can be accurately replicated in the tool mating region 20, and those surfaces 718, 720 that cannot be accurately replicated in the tool mating region 20 are not contacted by any surface of the tool mating region 20 because the tool mating region 20 has been over-milled in the areas of the tool mating region 20 corresponding to the difficult to replicate femur surfaces 718, 720.The result is a tool 5 with a mating region 20 that accurately mates to the mating region of the femur 40.In the above-described overestimation process, the line contours 601 for the cortical bone may be subjected to overestimation while the line contours 602 for the trabecular bone are not subjected to overestimation.", "However, in other embodiments, the contour lines 601, 602 for both the cortical and trabecular bones are subjected to overestimation.", "The cortical bone contour lines 601 may be employed to generate a 3D computer generated cortical bone model, and the trabecular bone contour lines 602 may be employed to generate a 3D computer generated trabecular bone model.", "The cortical bone model and the trabecular bone model may be combined into a single 3D computer generated femur model 1040 [block 1501], as depicted in FIG.", "9A discussed below.", "Specifically, as can be understood from FIG.", "9A, which is a posterior view of the femur model 1040, once the contour lines are segmented and overestimated as described above, the contour lines may be imported into a 3D computer modeling program.", "The model program may then be used to generate 3D computer models of the cortical bone 601 and the trabecular bone 602 of the proximal femur 40.The model of the trabecular bone 602 may be subtracted from the model of the cortical bone 601 to create a hollow 3D computer generated femur model 1040, wherein the subtracted model of the trabecular bone 602 creates a hollow region of the femur model 1040 that represents the medullary canal 170.Overestimation processes are described in more detail in commonly-owned U.S. Patent Application Ser.", "No.", "61/083,053, entitled System and Method for Manufacturing Arthroplasty Jigs Having Improved Mating Accuracy, filed Jul.", "23, 2008, which is hereby incorporated by reference in its entirety.", "When reconstructing the contour lines into the femur model 1040, certain alignments have been found to be advantageous.", "For example, as indicated in FIG.", "7, which is an example superior view CT scan of the proximal femur 40 of FIG.", "2A, the CT scan may be reconstructed for proper coronal alignment by causing the coronal slices to be parallel to the femoral neck 35.For this procedure, the slice width and overlap may range from approximately 0.5 mm to approximately 2 mm.", "In one embodiment, a slice width and overlap of 0.5 mm is used.", "The DFOV may range between approximately 16 cm to approximately 26 cm field of view.", "In one embodiment, the reformatted CT scan may include up to one-third of the proximal femur 40, including the femoral head 30 and the lesser trochanter 740.In other embodiments, the CT scan may include a greater or lesser amount of the proximal femur.", "As indicated in FIG.", "8, which is an example CT scan of the proximal femur 40 of FIG.", "2A, wherein the proper alignment for the final CT reconstruction is shown from a coronal slice.", "Specifically, the final reconstruction alignment 1760a is set to an angle Q relative to the long axis 1761 of the femoral neck 35.Angle Q may range from approximately 30 degrees to approximately 60 degrees.", "In one embodiment, angle Q is 45 degrees.", "The slice width and overlap may range from approximately 0.5 mm to approximately 2 mm.", "In one embodiment, the slice width and overlap is 1 mm.", "The field of view may range from approximately 16 mm to approximately 26 mm.", "In one embodiment, the scan may include up to one-third of the proximal femur 40, including the femoral head 30 and the lesser trochanter 740.In other embodiments, the CT scan may include a greater or lesser amount of the proximal femur.", "V. Preoperative Planning of Tool As can be understood from FIGS.", "1A-1C and the immediately preceding discussion, once the medical images 500 are segmented to identify the bone contour lines 502 [block 1500 and block 1602], the contour lines are overestimated as necessary, and the contour lines are compiled or reconstructed into a 3D model of the femur via a computer modeling program [block 1501], the pre-operative planning process may begin [block 1604], wherein the 3D bone model is utilized to determine: (1) the proper size and placement of a femoral component (e.g.", "the prosthetic device that will be implanted in the femur); and (2) the location of the resection plane for resection of the femur head and neck, wherein the resection is made to allow for the implantation of the femoral component in the resected femur.", "The following preoperative planning methods may employ a 3D computer modeling program, such as, for example, Solidworks or Paraview, in the generation, placement, manipulation, determination and importation of various 3D computer models described below.", "As can be understood from FIG.", "1B and FIGS.", "9A and 9B, which are respective transparent posterior and superior views of a 3D computer generated model 1040 of the proximal femur 40 of FIG.", "2A, in one embodiment, the preoperative planning may begin with the femur model 1040, a 3D computer generated sphere model 701, and a 3D computer generated rod model 702 being imported into a modeling space [block 1502].", "As can be understood from FIGS.", "9A and 9B, the femur model 1040, which is a result of the compiled or reconstructed contour lines, some of which may have been overestimated, may have a head 30, a neck 35, a shaft 51, a greater trochanter, and an medullary canal 170.As indicated in FIGS.", "9A and 9B, the models 701, 702, 1040 are combined together in a superpositioned arrangement.", "Specifically, the rod model 702 may be positioned so that it generally aligns with the center of the medullary canal 170 of the shaft of the femur model 1040, which generally corresponds to a central axis 100 of the shaft of the femur.", "In other words, the rod 702 may be positioned to be generally coaxial with the femur axis 100.The sphere model 701 may be positioned so the centers of the sphere 701 and head 35 are located at the same point.", "The diameter of the sphere model 701 may be increase or decreased to cause the sphere model 701 to generally approximate the femoral head 30 such that the hemispherical surfaces of the head 30 and the sphere 701 are generally coextensive for a significant portion of the hemispherical surface of the head 30.Generally, if there is damage to the head 30, the damage is typically to the superior and anterior surfaces, so the sphere 701 is typically positioned and sized such that hemispherical surface of the sphere 701 is generally coextensive with the inferior and posterior regions of the head 30.Once the sphere 701 is properly placed and sized, the center 703 of the sphere 701 will generally approximate the center of the hip joint.", "The proper positioning and sizing of the models 701, 702 can be verified by looking at both posterior (FIG.", "9A) and superior (FIG.", "9B) views.", "As can be understood from FIG.", "1B and FIG.", "9C, which is the same view as FIG.", "9B, except with a femoral component model 850 depicted with the other models 701, 702, 1040, a 3D computer generated femoral component model 850 may be imported into the modeling space [block 1503].", "The femoral component model 850 may include a shaft 804, a head 802 and a spacer region 801.The spacer region 801 may have a surface 803 that abuts against the surface of the bone resection when the actual implant is properly and fully implanted in the resected femur.", "The 3D femoral component model 850 may be selected from a database of femoral component models, the models in the data base corresponding to the sizes of femoral components available from a selected manufacturer.", "Size selection is based on the shape and size of the medullary canal 170.Once the position of the neck resection has been determined, the largest component that fits within the canal is chosen.", "The sphere model 701 and rod model 702 are used to plan the proper alignment and placement of the femoral component model 850.Specifically, the femoral component model 850 may be superimposed with the rest of the models 701, 702, 1040 such that the long axis of the shaft 804 of the component 800 generally corresponds to the long axis of the rod 702 in a generally coaxial manner, and the center of the head 802 of the component model 850 generally corresponds to the approximated hip joint center 703.To properly position the component model 850, the size and the shaft to neck angle of the spacer 801 may be adjusted according to the ranges available from the manufacturer for the femoral component.", "The above-described embodiment superimposes the sphere and rod models 701, 702 on the femur model 1040 prior to superimposing the femoral component model 850 and using the sphere and rod model locations to position and size the femoral component model 850.However, in other embodiments, the femoral component model 850 may be superimposed on the femur model 1040 for positioning and sizing without the presence and use of the sphere and rod models 701, 702.As can be understood from FIGS.", "1B and 1C and FIG.", "10, which is an isometric posterior view of the femoral model 1040 of FIG.", "9C, except with the other models 701, 702, 850 hidden for clarity purposes, a 3D computer generated tool blank model 550 is generated [block 1504] and imported into the modeling space to be superpositioned with the femoral model 1040 to define the mating region 20 and saw guide 1725 in the tool blank model 550 [block 1505 and 1606].", "In one embodiment for a posterior approach surgical procedure, the tool blank model 550 is positioned over the posterior surface of the femur model 1040 such that: (1) the surfaces of the femur model 1040 corresponding to the mating contact surfaces 708, 710 and non-contact surfaces 718, 720 of the femur 40, as discussed in detail below with respect to FIG.", "13, are covered by the tool 5; and (2) the head 30 of the femur model 1040 is exposed.", "As shown in FIG.", "11, which is a inferior-posterior isometric view of what is depicted in FIG.", "10, a distal portion 1750 of the tool blank model 550 may be removed to provide a non-contacting arrangement between the resulting tool 5 and non-mating regions of the proximal femur 40, such as those regions near the greater trochanter 115.As can be understood from FIGS.", "1B and 1C and FIG.", "12, which is generally the same view as FIG.", "11, except the femoral component model 850 is visible and the tool blank model 550 is now a customized tool model 603, once the tool blank model 550 is properly positioned on the femur model 1040, the tool mating region 20 and saw guide 1725 may be defined and imported into the tool blank model 550 to create the tool model 603 [block 1506 and block 1606].", "Specifically, those mating contact surfaces 708a, 710a and non-contacting surfaces 718a, 720a of the tool mating region 20 that respectively correspond to the contact surfaces 708, 710 and non-contact or overestimated surfaces 718, 720 of the femur 40 of FIG.", "13 are identified on the surface of the femur model 1040 and imported or otherwise used to define the contacting surfaces 708a, 710a and non-contacting surfaces 718a, 720a in the mating region of the tool blank model 550.As can be understood from FIG.", "1B, in one embodiment, the contacting surfaces 708, 710 and non-contacting surfaces 718, 720 of the femur model 1040 may be identified and defined as 3D surface models 537, 539 or other types of “data” that are imported into the tool blank model 550 to create the contacting surfaces 708a, 710a and non-contacting surfaces 718a, 720a in the mating region of the tool blank model 550 [block 1506].", "As can be understood from FIG.", "12, since the femoral component model 850 is properly positioned in the femur model 1040 in a manner that is predicted to give a desirable surgical outcome for the hip implantation, the surface 803 of the spacer region 801 of the component model 850 may be coplanar to the resection plane 805 needed to allow the actual implanted femoral component to achieve the implant positioning that will achieve the predicted desirable surgical outcome.", "In other words, the spacer region surface 803 will correspond to the position and orientation of the resection plane 805 when the component model 850 is properly positioned in the femur model 1040.Thus, the position and orientation of the spacer region surface 803 may be used to define the position and orientation of the resection plane 805 and, as can be understood from FIG.", "1B, a resection plane model 538 or other types of “data” may be defined and imported into the tool blank model 550 to define the saw guide 1725 in the tool blank model 550 [block 1506].", "Since the location and orientation of the surface models 539, 537 and plane model 538 may be referenced relative to each other due to the femur, component and blank models 1040, 805, 550 being superimposed with each other, the position and orientation relationships are maintained in the resulting tool model 603 [block 1507].", "Thus, for the resulting tool model 603 and tool 5 manufactured therefrom, the saw guide 1725 may be positioned and oriented relative to the customized mating or indexing region 20 such that, when the mating surfaces 708a, 710a of the mating region 20 matingly contact the bone surfaces 708, 710 when the tool mating region 20 matingly receives therein the region of the femur 40 having the bone surfaces 708, 710, the saw guide 1725 may be oriented over the femur neck 35 such that the saw guide 1725 corresponds with a desired resection plane 805 through the femoral neck 35 that was identified during the preoperative planning.", "In other words, the cavity or mating region 20 of the tool 5 conforms to the segmented CT scans or MRI scans, overestimated as necessary, of the patient's femur, and the saw guide 1725 is positioned so as to result in a preoperatively planned resection of the proximal femur when the tool mating region 20 matingly engages the proximal femur and a sawing action is guided by the saw guide 1725.Proper alignment of the saw slot 1725 with the preoperatively planned resection plane exposes the femoral neck to provide a properly oriented surface for proper alignment of the femoral component.", "A properly positioned femoral component prevents or at least minimizes the chances of several undesirable complications.", "For example, an improperly positioned femoral component can cause a change of leg length, dislocation of the hip or perforation of the femur.", "As can be understood from FIGS.", "1A-1C, once the tool model 603 is defined, the tool model 603 may be used to generate automated manufacturing instructions (e.g., tool paths, etc.).", "The tool model 603 or automated manufacturing instructions are sent to the CNC machine 10 from the preoperative planning system 6 [block 1508], and the actual tool 5 is manufactured from an actual tool blank 50 via the CNC machine 10 [block 1608].", "The finished tool 5 may be marked with patient data (e.g., name, hip identification, etc.", "), surgeon name, medical facility name, or other information.", "The tool 5 may then be sterilized, packaged and sent to the surgeon [block 1610].", "During surgery, the surgeon may fit the tool appropriately on the femur and, in one embodiment, drill into the hole 1715 of the fastener feature 1710 at the top side 1755 of the tool and insert a fastening member 1716 to stabilize the tool [block 1612].", "In some embodiments, the tool 5 may be held in place by the surgeon or other medical personnel.", "Once positioned, the surgeon may place a saw blade through the saw slot 1725 and prepare to saw through the resection plane to make at least a partial head and neck resection [block 1614].", "Once the resection is at least partially complete, the tool may be discarded [block 1616].", "In some embodiments, the tool 5 may remain in place until the resection is complete.", "The surgeon may then further prep the resected proximal femur and then implant the femoral component 800 in a manner that replicates the preoperative planning such that the surface 803 abuts against the resection surface of the femur.", "As the size selection and positioning of the femoral component are determined via computer modeling during the preoperative planning process, and the tool 5 is custom configured to facilitate the preoperatively planned positioning of the femoral component, the tool 5 disclosed herein facilitates FIRS that is substantially more likely to result in a positive surgical outcome for the patient as compared to conventional methods that rely on x-rays, hand measuring techniques and surgeon visual assessment.", "In other words, the tool 5 decreases the risks commonly associated with an improperly placed femoral component in total hip replacement surgery, such as dislocation of the hip, a change in the length of the leg or perforation of the femur.", "As the surgical planning is integrated into the tool 5 prior to the time of surgery, the surgical time is substantially reduced because the surgeon simply has to cause the tool 5 to engage the proximal femur, as opposed to determining the proper location for the resection based off of visual inspection at the time of surgery.", "Thus, the tool 5 aids the surgeon in accurately and quickly placing the femoral component 800.In other words, the tool 5 also decreases the risks associated with the length of the surgical time, such as, infection, excessive bleeding, etc.", "In one embodiment and to a greater or lesser extent, the above-described POP procedure is a manual process, wherein computer generated 3D models 701, 702, 1040, 850 are manually manipulated relative to each other by a person sitting in front of a computer 6 and visually observing the 3D models 701, 702, 1040, 850 on the computer screen 9 and manipulating the 3D models 701, 702, 1040, 850 via the computer controls 11.In other embodiments and to a greater or lesser extent, the POP process is generally or completely automated.", "For example, a computer program may manipulate computer generated 3D models 701, 702, 1040, 850 relative to each other to preoperatively plan the tool 5.In some embodiments, the above-described POP process may have portions that are generally manual while other portions that are generally automated.", "VI.", "Candidate Contact and Non-Contact Surfaces of Proximal Femur As described in detail above, the mating region 20 of the tool 5 may be customized based on a patient's individual bone shape.", "The tool 5 may be machined, molded or otherwise formed from the non-customized state as illustrated in FIGS.", "2B-2E to a customized state as indicated in FIGS.", "2F-2H, based on a patient's individual bone scan, for example an MRI scan or CT-scan.", "For example, the bone scan data may be utilized to generate a 3D computer generated model 1040 of the patient's proximal femur 40.A 3D computer generated model 550 of the blank of the tool 5, the 3D femur model 1040, and 3D computer generated models of the implant component 850, the sphere 701, and the rod 702 may be superimposed and aligned as described above to preoperatively plan the patient specific tool 5.That is, through the information received from the MRI scan or CT-scan and the computer modeling, the tool 5 may be customized at the mating region 20 such that the tool 5 will have mating or indexing surfaces 708a, 710a of the mating region 20 that generally conform to the predetermined specific surface geometry of the patient's own proximal femur 40.In some embodiments, the predetermined specific geometry will be that of surfaces 708, 710 discussed with respect to FIG.", "13, which is a posterior medial view of the proximal femur 40 of FIG.", "2A showing the surfaces 708, 710 of the femur 40 that are mated with the index surfaces 708a, 710a of the tool mating region 20 and the surfaces 718, 720 that correspond to over-estimated or non-contacting surfaces 718a, 720a of the tool mating region 20.In one embodiment, the femur mating region depicted in FIG.", "13 may be applicable to a posterior approach to help with stable positioning of the tool 5 on the femur 40.As shown in FIG.", "13, a first mating surface 708 covers portions of the posterior region of the neck 35, starting medially between approximately 1 mm and approximately 5 mm after the cartilage covering the head 30 of the femur 40 terminates laterally and laterally extends between approximately 15 mm and approximately 35 mm to or towards the trochanteric fossa 210.The inferior boundary of surface 708 may terminate approximately 5 mm superior to the inferior border between the posterior and anterior surfaces of the neck 35, or may extend up to approximately 5 mm anterior past this border.", "The superior boundary of mating surface 708 may extend approximately 0 mm to approximately 5 mm posterior to the superior junction between the posterior surface and the anterior surface of the neck 35.A second mating surface 710 may be a narrow band measuring between approximately 0.5 mm and approximately 12 mm medial-lateral.", "The second mating surface 710 may follow along the intertrochanteric crest 116.Mating surface 710 may begin approximately 0 mm to approximately 12 mm superior to the lesser trochanter 740 and may extend approximately 0 mm to approximately 18 mm inferior to the most superior tip 215 of the posterior surface of the greater trochanter 115.These mating surfaces 708, 710 of the femur 40 may be used to define the mating contact surfaces 708a, 710a of the tool mating region 20 (see FIG.", "2G) such that the tool contact surfaces 708a, 710a may matingly contact the femur surfaces 708, 710 when the tool mating region 20 mating receives or engages the femur 40 as depicted in FIG.", "2H.", "The non-mating surfaces 718, 720 of the femur 40, which are spanned in a spaced-apart or non-contacting arrangement by corresponding non-contacting surfaces 718a, 720a of the tool mating region 20, as depicted in FIG.", "2H, are also depicted in FIG.", "13.A first non-mating surface 718 may include portions of the posterior greater trochanter 115 and extend superior-inferior adjacent the intertrochanteric crest 116.The medial boundary of the first non-mating surface 718 may be the second mating surface 710, and may extend medial-lateral approximately 0 mm to approximately 12 mm.", "The second non-mating surface 20 may span portions of the trochanteric fossa 210, and may have a medial boundary that is the first mating surface 708 and a lateral boundary that is the second mating surface 710, and a medial-lateral width that may vary between approximately 0 mm and approximately 20 mm.", "Both the first non-mating surface 718 and the second non-mating surface 720 may have inferior-superior dimensions similar to the first mating surface 708 and the second mating surface 710.As discussed in detail above, during segmentation, contour line portions corresponding to non-mating surfaces 718, 720 and osteophytes may be overestimated (e.g., moved outward from the interior of the bone and smoothed) such that portions of the tool mating region 20 defined according to those overestimated contour line portions are over-machined, ensuring that little or no contact occurs between the resulting non-mating surfaces 718a, 720a of the tool mating region 20 (see FIG.", "2G) and the corresponding non-mating surfaces 718, 720 of the bone when the tool mating region 20 matingly receives the region of the femur 40 having the non-mating surfaces 718, 720, as shown in FIG.", "2H.", "As just discussed with respect to FIG.", "13, in one embodiment, the femur 40 may include contact surfaces 708, 710 and non-contact surfaces 718, 720 such that a tool 5 configured for a posterior approach may have a mating region 20 configured to have corresponding mating contact surfaces 708a, 710a and non-contacting surfaces 718a, 720a, as indicated in FIGS.", "2G and 2H.", "In other embodiments, the tool mating region 20 may be such that the mating contact and non-contact surfaces of the tool mating region 20 are configured to correspond to mating and non-contact surfaces of other regions of the femur 40 as described below with respect to FIGS.", "14A-14B, 15 and 16A-16B.", "As shown in FIGS.", "14A-14B, which are, respectively, posterior and anterior views of the proximal femur 40, the mating region of the femur 40 may be appropriate for a posterior or anteriorlateral surgical approach.", "For example, the mating region of the femur 40 may include mating surfaces 700a, 701a, 702a, 704a.", "As can be understood from FIG.", "2I, which is a view similar to FIG.", "2G, except of a tool mating region 20 configured to matingly engage the mating surfaces 700a, 701a, 702a, 704a depicted in FIGS.", "14A-14B, the mating surfaces 700a, 701a, 702a, 704a of the femur 40 may be matingly contacted by corresponding mating or index contact surfaces 700b, 701b, 702b, 704b of the tool mating region 20 to help stabilize the positioning of the tool 5 on the femur 40.In other words, like the tool mating region 20 depicted in FIG.", "2G is configured to matingly engage the mating surfaces of the femur 40 depicted in FIG.", "13, the tool mating region 20 depicted in FIG.", "2I is configured to matingly engage the mating surfaces of the femur 40 depicted in FIGS.", "14A-14B.", "As indicated in FIGS.", "14A-14B, a first mating surface 700a includes portions of the posterior region 724 of the neck 35, having a medial starting point between approximately 1 mm and approximately 5 mm after the cartilage covering the femoral head 30 terminates laterally and extends laterally between approximately 15 mm and approximately 35 mm to or towards the trochanteric fossa 210.The inferior border of the first mating surface 700a begins approximately midway superiorly-inferiorly along the intertrochanteric crest 116, and follows the long axis of the neck 35.The superior border of the first mating surface 700a is between approximately 1 mm and approximately 3 mm below the superior junction 728 between the posterior and anterior surfaces of the neck 35.A second mating surface 701a has approximately the same medial-lateral width as section 700a, but may terminate before the tubercle 730 of the femur 40.The superior border of the second mating surface 701a is approximately 1 mm to approximately 3 mm below the superior junction 728 between the posterior and anterior surfaces of the neck 35.The inferior-superior distance of second mating surface 701a is between 5 and 10 mm.", "A third mating surface 702a is a narrow band, measuring generally medial-lateral between approximately 0.5 mm and approximately 8 mm, that follows along the intertrochanteric crest 116.Mating surface 702a begins approximately midway superior-inferior along the intertrochanteric crest 116 and may extend any length greater than approximately 5 mm to or towards the most superior tip 215 of the posterior surface of the greater trochanter 115.A fourth mating surface 704a lies on the anterior greater trochanter 115, lateral to the tubercle 730 of the femur 40, and inferior to the origin of the obturator internus 732.The medial-lateral distance of mating surface 704a measures between approximately 3 mm to approximately 14 mm, and its inferior-superior distance measures between approximately 3 mm to approximately 10 mm.", "As indicated in FIGS.", "14A-14B, mating surfaces 700a, 701a, 702a, 704a may be separated by non-mating surfaces 712, 714, 716 that are spanned by and correspond respectively with non-contacting surfaces 22, 24, 26 of the mating region 20 of the tool 5 (see FIG.", "2I).", "A first non-mating surface 712 may include portions of the tubercle 730 of the femur 40.A second non-mating surface 714 may span portions of the trochanteric fossa 210.A third non-mating surface 716 may contain the superior junction 728 between the posterior and anterior surfaces of the neck 35, and may be between approximately 1 mm to approximately 5 mm anterior-posterior.", "In a manner similar to that described above with respect to the non-contact surfaces 718a, 720a of the tool mating region 20 depicted in FIGS.", "2G-2H, during segmentation, contour line portions corresponding to non-mating surfaces 712, 714, 716 may be overestimated (e.g., moved outward from the interior of the bone and smoothed) such that portions of the tool mating region 20 defined according to those overestimated contour line portions are over-machined, ensuring that little or no contact occurs between the resulting non-mating surfaces 22, 24, 26 of the tool mating region 20 (see FIG.", "2I) and the corresponding non-mating surfaces 712, 714, 716 of the femur 40 when the tool mating region 20 matingly receives the region of the bone having the non-mating surfaces 712, 714, 716.FIG.", "15, which is an isometric posterior view of the proximal femur 40, illustrates yet another mating region of the femur 40 that may be used to define the mating region 20 of another embodiment of the tool 5.As can be understood from FIG.", "15 and FIG.", "2J, which is the same view as 2G, except of a tool 5 with a mating region 20 configured to matingly engage the mating region of the femur 40 depicted in FIG.", "15 instead of the mating region of the femur 40 depicted in FIG.", "13, the tool mating region 20 may be adapted to receive therein and mate with surfaces of the proximal femur 40, such as, for example, the posterior region 37 of the neck 35, a medial posterior surface 38 of the greater trochanter 115 between the intertrochanteric crest 116 and trochanteric fossa 118, and a region 39 that is part of the lateral posterior greater trochanter 115 and the lateral posterior body of the femur bordering the lateral side of the intertrochanteric crest 116.More specifically, the mating surface 37 may cover portions of the posterior region of the neck 35, starting medially between approximately 1 mm and approximately 5 mm after the cartilage covering the head 30 of the femur 40 terminates laterally and laterally extends between approximately 15 mm and approximately 35 mm to or towards the trochanteric fossa 118.Region 38 may be a band, extending from the lesser trochanter 740 to the anterior surface of the femur, and ranging in width from between approximately 0 mm to approximately 14 mm.", "The medial border of region 38 is the trochanteric fossa 118 and the lateral border is approximately the intertrochanteric crest 116.Region 39 begins medially at approximately the crest 116, and may extend from 0 mm to approximately the edge of the posterior surface of the femur 40.The inferior/superior length of region 39 may be 0 mm, or may extend from the lesser trochanter 740 to the superior border of the posterior surface of the femur 40.The surfaces 37, 38, 39, which are to be mated or indexed by the tool index surfaces 101, 102, 103 of the mating region 20 of the tool 5, may be separated by areas of non-mating surfaces 110, 111 that are spanned by overestimated or non-contacting surfaces 22, 24 of the mating region 20 of the tool 5.The non-contacting surfaces 22, 24 of the mating region 20 of the tool 5 do not contact the corresponding non-mating surfaces 110, 111 of the femur 40 and may be generated via an over-estimating process during image segmentation.", "The non-mating surfaces 110, 111 of the proximal femur 40 may be portions 111 of the trochanteric fossa 118 (i.e., the depression between the greater trochanter and the femur neck) and portions 110 of the intertrochanteric crest 116.More specifically, the non-mating surface or portion 111 may span portions of the trochanteric fossa 118, and may have a medial boundary that is the mating surface 37 and a lateral boundary that is the mating surface 38, and a medial-lateral width that may vary between approximately 0 mm and approximately 20 mm.", "Non-mating surface or portion 110 may be a band including the intertrochanteric crest 116, and may extend from the lesser trochanter 740 to the most superior point of the greater trochanter 115.The medial-lateral width of the surface 110 may be from approximately 0 mm to approximately 12 mm.", "Generally, any surface of mating region 20 that is outside of tool mating surfaces 101, 102, 103 (which correspond to femur mating surfaces 37, 38, 39, respectively) may be tool non-contacting surfaces 22, 24, which correspond, respectively to femur non-contacting surfaces 110,111.As can be understood from FIG.", "15, the tool may be placed on the femur 40 such that the mating region 20 of the tool 5 covers and matingly receives the femur area encompassing the mating surfaces 37, 38, 39 and non-mating surfaces 110, 111 of the proximal femur 40.As discussed above, non-mating regions 110, 111, including portions of the trochanteric fossa 118 (the depression between the greater trochanter and the neck of femur) and the intertrochanteric crest 116, are not easily estimated due to drastic changes in surface geometry, and corresponding non-mating surfaces 22, 24 of the mating region 20 of the tool 5 do not contact these surfaces 110, 111 when the region of the femur that includes the femur mating surfaces 37, 38, 39 and non-mating surfaces 22, 24 are matingly received by the mating region 20 of the tool 5.In other embodiments, as shown in FIGS.", "16A-16B, the mating region of the femur 40 may be configured for use with any surgical approach, and, in a manner similar to that discussed above with respect to FIGS.", "2G-2H and 13 and FIGS.", "2I and 14A-14B, the tool mating region 20 may be configured to matingly engage the mating region of the femur 40 as depicted in FIGS.", "16A-16B.", "As illustrated in FIGS.", "16A-16B, a first mating surface 706 of the femur 40 may include the entire or any portion of the circumferential surface 734 of the neck 35.On the posterior surface, the mating surface 706 may start medially between approximately 1 mm and approximately 5 mm after the cartilage covering the head 30 of the femur 40 terminates laterally and extend laterally up to approximately 8 mm past the intertrochanteric crest 116, extending along the intertrochanteric crest 116 from the lesser trochanter 740 to or towards the tip 215 of the greater trochanter 115.On the anterior surface, the mating surface 706 may start medially between approximately 1 mm and approximately 5 mm after the cartilage covering the head 30 of the femur 40 terminates laterally and extend laterally up to approximately 8 mm laterally past the intertrochanteric line 738.The surface 706 may also contain the medial surface of the greater trochanter 115.As discussed above, portions within the mating surface 706 may be overestimated if geometry is too erratic for the surface to be accurately captured with the CT scan.", "Some such areas may include the trochanteric fossa 210, the superior junction 728 between the posterior and anterior surfaces of the neck 35, and the tubercle 730.As can be understood from the preceding discussion regarding FIGS.", "13-16B, the configuration of the mating region 20 of the tool 5 may be determined from and correspond to the specific surface geometry or topography of the surface of the femur 40 that corresponds to the surgical approach for which the tool 5 is being designed.", "Thus, in some embodiments, the tool mating region 20 may be configured to have the contact and non-contact surfaces that correspond to at least some, if not all, of the contact and non-contact surfaces of the femur mating region discussed above with respect to FIG.", "13.In other embodiments, the tool mating region 20 may be configured to have the contact and non-contact surfaces that correspond to at least some, if not all, of the contact and non-contact surfaces of the femur mating region discussed above with respect to FIGS.", "14A-14B.", "In yet other embodiments, the tool mating region 20 may be configured to have the contact and non-contact surfaces that correspond to at least some, if not all, of the contact and non-contact surfaces of the femur mating region discussed above with respect to FIG.", "15.In still other embodiments, the tool mating region 20 may be configured to have the contact and non-contact surfaces that correspond to at least some, if not all, of the contact and non-contact surfaces of the femur mating region discussed above with respect to FIGS.", "16A-16B.", "Thus, regardless of the surgical approach used and the mating region of the femur 40 encountered, the tool mating region 20 may be based off of the medical imaging scans take of the femur 40 and preoperatively planned via 3D computer generated models to have a customized engagement with the femur 40 when applied to the femur to guide a resection in a THR.", "The arrangement between the customized mating region 20 of the tool 5 and the saw guide 1725 may be such that when the mating region 20 matingly receives the mating region of the femur 40, the saw guide 1725 may cause a resection procedure guided by the guide 1725 to create a preoperatively planned resection of the femur 40.While the above disclosed embodiments of a arthroplasty tool 5 or surgical guide tool 5 are described in the context of a tool 5 for use in a total hip replacement procedure, the features, methods of determining proper placement of the prosthetic device and the mating surfaces and the generation thereof disclosed herein may be equally useful and applicable for use in total arthroplasty procedures in other joint contexts.", "Thus, the disclosure provided herein should be considered as encompassing tools and the generation thereof for any total arthroplasty procedures.", "Although the present invention has been described with reference to preferred embodiments, persons skilled in the art will recognize that changes may be made in form and detail without departing from the spirit and scope of the invention." ] ]
Patent_15875895
[ [ "COMPOUNDS AND METHOD FOR TREATING AUTOIMMUNE DISEASES", "Compounds and embodiments of a method for treating and/or preventing autoimmune diseases are disclosed.", "The method includes administering to a subject having an autoimmune disease, such as an inflammatory bowel disease, a therapeutically effective amount of a compound according to formula I wherein X and Y independently are O or NR1; each R1 is independently H or C1-C6 alkyl; ring A is aryl; each R2 independently is H, alkyl, alkoxy, amide, cyano, halo, haloalkyl, hydroxyalkyl, heteroalkyl, heterocyclyl, sulfonyl, sulfonamide, or two R2 groups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered ring system; p is 0, 1, 2, 3, or 4; R3 and R4 independently are H or C1-C6 alkyl; and R5 is halo, cyano, or C1-C6 alkyl." ], [ "1.A method of treating or preventing alopecia in a subject in need thereof comprising topically administering to the subject a therapeutically effective amount of a compound selected from a hydrate thereof, a solvate thereof, an N-oxide thereof, a salt thereof, or a combination thereof.", "2.The method of claim 1, wherein the compound is in a pharmaceutical composition further comprising a pharmaceutical acceptable carrier, diluent, excipient, preservative, stabilizer, or mixture thereof.", "3.The method of claim 2, wherein the pharmaceutical composition is a solution, gel, ointment, cream, suspension, patch, adhesive disc, aerosol, or a combination thereof.", "4.The method of claim 2, wherein the pharmaceutical composition is a topical solution.", "5.The method of claim 1, wherein the subject has been identified as having alopecia or at a risk of developing alopecia.", "6.The method of claim 1, wherein the compound is administered prophylactically to prevent or delay the onset of alopecia.", "7.The method of claim 1, wherein the compound is (Sodium (5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyriniidin-4-ylamino)-2-oxobenzo [d]oxazol-3 (2H)-yl)methyl phosphate).", "8.The method of claim 1, wherein the compound is (5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)benzo[d]oxazol-2(3H)-one).", "9.The method of claim 1, wherein the compound is a salt of 10.The method of claim 9, wherein the salt is selected from the group consisting of sodium, potassium, calcium, magnesium, ammonium, tetraalkylammonium, hydrochloride, hydrobromide, tartrate, mesylate, acetate, maleate, oxalate, sulfuric acid, nitrate, phosphoric acid, acetate, trifluoroacetate, propionate, glycolate, pyruvate, malonic acid, succinic acid, fumerate, citrate, benzoate, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, lithium, iron, zinc, copper, manganese, aluminum, salts of primary, secondary, and tertiary amines, salts of substituted amines, salts of cyclic amines, isopropylamine, trimethylamine, iethylamine, triethylamine, tripropylamine, ethanolamine, 2-dimethylaminoethanol, 2-diethylaminoethanol, dicyclohexylamine, lysine, arginine, histidine, caffeine, procaine, hydrabamine, choline, betaine, ethylenediamine, glucosamine, methylglucamine, theobromine, purines, piperazine, piperidine, N-ethylpiperidine, polyamine resins, diethylamine, xinafoate salt, and a mixture thereof.", "11.The method of claim 9, wherein the salt is a hydrochloride salt.", "12.The method of claim 9, wherein the salt is a trifluoroacetate salt.", "13.The method of claim 1, wherein the compound has a particle size of about 0.4 μm to about 5 μm.", "14.The method of claim 1, wherein the compound has a particle size of less than about 5 μm.", "15.The method of claim 1, wherein the therapeutically effective amount is a daily dose of about 1 mg/day to about 2 grams/day.", "16.The method of claim 1, wherein the therapeutically effective amount is about 0.0001 mg/kg/day to about 100 mg/kg/day.", "17.A method of treating or preventing alopecia in a subject in need thereof comprising orally administering to the subject a therapeutically effective amount of a compound selected from a hydrate thereof, a solvate thereof, an N-oxide thereof, a salt thereof, or a combination thereof.", "18.The method of claim 17, wherein the compound is in a pharmaceutical composition further comprising a pharmaceutical acceptable carrier, diluent, excipient, preservative, stabilizer, or mixture thereof.", "19.The method of claim 18, wherein the pharmaceutical composition in the form of lozenges, tablets, pills, capsules, troches, suspensions, dispersible powder, granules, emulsions, syrups, elixirs, enterocoated tablets, enterocoated pills, enterocoated capsules, or combinations thereof.", "20.The method of claim 17, wherein the compound has a particle size of about 0.4 μm to about 5 μm.", "21.The method of claim 17, wherein the compound has a particle size of less than about 5 μm.", "22.The method of claim 17, wherein the compound is administered using a liposome delivery system.", "23.The method of claim 17, wherein the compound is administered using an emulsion delivery system.", "24.The method of claim 17, wherein the therapeutically effective amount is a daily dose of about 1 mg/day to about 2 grams/day.", "25.The method of claim 17, wherein the therapeutically effective amount is about 0.0001 mg/kg/day to about 100 mg/kg/day.", "26.The method of claim 17, wherein the compound is (Sodium (5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyriniidin-4-ylamino)-2-oxobenzo [d]oxazol-3 (2H)-yl)methyl phosphate).", "27.The method of claim 17, wherein the compound is (5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)benzo[d]oxazol-2(3H)-one).", "28.The method of claim 17, wherein the compound is a salt of 29.The method of claim 28, wherein the salt is selected from the group consisting of sodium, potassium, calcium, magnesium, ammonium, tetraalkylammonium, hydrochloride, hydrobromide, tartrate, mesylate, acetate, maleate, oxalate, sulfuric acid, nitrate, phosphoric acid, acetate, trifluoroacetate, propionate, glycolate, pyruvate, malonic acid, succinic acid, fumerate, citrate, benzoate, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, lithium, iron, zinc, copper, manganese, aluminum, salts of primary, secondary, and tertiary amines, salts of substituted amines, salts of cyclic amines, isopropylamine, trimethylamine, iethylamine, triethylamine, tripropylamine, ethanolamine, 2-dimethylaminoethanol, 2-diethylaminoethanol, dicyclohexylamine, lysine, arginine, histidine, caffeine, procaine, hydrabamine, choline, betaine, ethylenediamine, glucosamine, methylglucamine, theobromine, purines, piperazine, piperidine, N-ethylpiperidine, polyamine resins, diethylamine, xinafoate salt, and a mixture thereof.", "30.The method of claim 28, wherein the salt is a hydrochloride salt.", "31.The method of claim 28, wherein the salt is a trifluoroacetate salt.", "32.The method of claim 17, wherein the subject has been identified as having alopecia or at a risk of developing alopecia.", "33.The method of claim 17, wherein the compound is administered prophylactically to prevent or delay the onset of alopecia." ], [ "<SOH> BACKGROUND <EOH>Inflammatory bowel diseases are a group of chronic inflammatory conditions that primarily affect the colon and small intestine.", "Inflammatory bowel diseases include, but are not limited to, Crohn's disease (also known as regional enteritis, Crohn's ileitis, and granulomatous colitis), collagenous colitis, granulomatous ileocolitis, idiopathic inflammatory bowel disease, ileitis, irritable bowel syndrome, lymphocytic colitis, regional enteritis, spastic colon, and ulcerative colitis.", "Common symptoms of inflammatory bowel diseases include intestinal inflammation (e.g., redness and/or swelling), abdominal pain, abdominal cramps, bloody diarrhea, vomiting, pelvic muscle spasms, and/or fever.", "Weight loss, sweats, malaise, and/or arthralgias also may occur.", "Inflammatory bowel disease symptoms typically wax and wane in intensity over time.", "Two of the most common inflammatory bowel diseases are ulcerative colitis and Crohn's disease.", "Ulcerative colitis is characterized by inflammation that is primarily limited to the mucosa and submucosa of the colon, or large intestine, and the rectum.", "Crohn's disease can cause inflammation anywhere throughout the digestive tract, and penetrates deeper into the tissues.", "In some cases, bowel inflammation results when the immune system attacks a pathogen, such as a virus or bacterium, or an intraluminal antigen, such as a protein from cow's milk.", "In other cases, inflammatory bowel disease may be an autoimmune process.", "Genetic predisposition also may have a role in certain cases.", "Inflammatory bowel disease can severely impact a subject's life, and current therapies frequently provide unsatisfactory and insufficient relief." ], [ "<SOH> SUMMARY <EOH>This disclosure concerns compounds and embodiments of a method for treating and/or preventing inflammatory bowel diseases.", "In some embodiments, a method for treating a disease, such as an inflammatory bowel disease includes administering to a subject identified as having an inflammatory bowel disease, or being at risk of developing an inflammatory bowel disease, a therapeutically effective amount of a compound according to formula I wherein X and Y independently are O or NR 1 ; each R 1 is independently H or C 1 -C 6 alkyl; ring A is aryl; each R 2 independently is H, alkyl, alkoxy, amide, cyano, halo, haloalkyl, hydroxyalkyl, heteroalkyl, heterocyclyl, sulfonyl, sulfonamide, or two R 2 groups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered ring system; p is 0, 1, 2, 3, or 4; R 3 and R 4 independently are H or C 1 -C 6 alkyl; and R 5 is halo, cyano, or C 1 -C 6 alkyl.", "In some embodiments, ring A is phenyl.", "In certain embodiments, the compound has the formula wherein R 1 is H or —CH 2 OP(O)(ONa) 2 , and R 2a -R 2c are as defined above for R 2 .", "In particular embodiments, the compound is selected from the group consisting of N2-(3,4,5-trimethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine; 4-[5-Methyl-4-(2-oxo-2,3-dihydro-benzooxazol-5-ylamino)-pyrimidin-2-ylamino]-N-phenyl-benzamide; N4-(benzo[d]oxazol-2(3H)-on-5-yl)-N2-(4-aminocarbonylphenyl)-5-methylpyrimidine-2,4-diamine; N2-(3,4-dimethyl-5-hydroxymethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine; N-Cyclobutyl-4-[5-methyl-4-(2-oxo-2,3-dihydro-benzooxazol-5-ylamino)-pyrimidin-2-ylamino]-benzamide; N4-(benzo[d]oxazol-2(3H)-on-5-yl)-N2-(3-methylsulfonyl)phenyl)-5-methylpyrimidine-2,4-diamine; 5-(2-(3-(fluoromethyl)-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)benzo[d]oxazol-2(3H)-one; N2-(3-fluoro-4-methyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine; N2-(3,5-dimethyl-4-hydroxymethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine; 5-[2-(3,4-Dimethyl-phenylamino)-5-methyl-pyrimidin-4-ylamino]-3H-benzooxazol-2-one; 5-(2-(3-chloro-4,5-dimethoxyphenylamino)-5-methylpyrimidin-4-ylamino)benzo[d]oxazol-2(3H)-one; 5-(2-(benzo[d]isoxazol-6-ylamino)-5-methylpyrimidin-4-ylamino)benzo[d]oxazol-2(3H)-one; N2-(3-methoxy-5-trifluoromethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine; N2-(3,5-dimethyl-4-fluoro)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine; N2-(3-methoxy-5-trifluoromethyl)phenyl-5-methyl-N4-[3-(phosphonooxy)methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl]-2,4-pyrimidinediamine bis-sodium salt; sodium (5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)-2-oxobenzo[d]oxazol-3(2H)-yl)methyl phosphate; 5-methyl-N4-[3-(phosphonooxy)methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl]-N2-(3,4,5-trimethyl)phenyl-2,4-pyrimidinediamine bis-sodium salt; and N2-(3,5-dimethyl-4-fluoro)phenyl-5-methyl-N4-[3-(phosphonooxy)methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl]-2,4-pyrimidinediamine bis-sodium salt.", "In some embodiments, the inflammatory bowel disease is Crohn's disease, collagenous colitis, granulomatous ileocolitis, idiopathic inflammatory bowel disease, ileitis, irritable bowel syndrome, lymphocytic colitis, regional enteritis, spastic colon, or ulcerative colitis.", "Administering the compound may include exposing to the subject to a first dose of the compound or a pharmaceutical composition comprising the compound.", "In some embodiments, the method further includes determining a therapeutic blood level of the compound or a metabolite thereof in the subject.", "The method may further include comparing the therapeutic blood level to a control, and adjusting a second dose of the compound, based at least in part on the comparison, to optimize therapeutic effect.", "For example, if the therapeutic blood level is greater than a control, the second dose may be decreased relative to the first dose.", "Alternatively, if the therapeutic blood level is less than a control, the second dose may be increased relative to the first dose.", "In certain embodiments, the therapeutically effective dose is in the range of from about 0.0001 mg/kg body weight/day to about 100 mg/kg/day, such as from about 5 mg/kg body weight/day to about 20 mg/kg/day.", "In one embodiment, the compound is administered serially in plural administrations to the subject.", "The method may include administering two or more compounds according to formula I serially or in combination to the subject.", "In some embodiments, the compound is administered as a pharmaceutical composition.", "The compound may be administered prophylactically.", "In some embodiments, the method further includes administering a second therapeutic to the subject.", "The second therapeutic may be administered in combination with the compound, or prior to or subsequent to the compound.", "In some embodiments, the second therapeutic is an analgesic, an antibiotic, an anticoagulant, an antibody, an anti-inflammatory agent, an immunosuppressant, a guanylate cyclase-C agonist, an intestinal secretagogue, or a combination thereof.", "The anti-inflammatory agent may be a steroid or a nonsteroidal anti-inflammatory agent.", "In certain embodiments, the nonsteroidal anti-inflammatory agent is selected from aminosalicylates, cyclooxygenase inhibitors, diclofenac, etodolac, famotidine, fenoprofen, flurbiprofen, ketoprofen, ketorolac, ibuprofen, indomethacin, meclofenamate, mefenamic acid, meloxicam, nambumetone, naproxen, oxaprozin, piroxicam, salsalate, sulindac, tolmetin, or a combination thereof.", "In some embodiments, the immunosuppressant is mercaptopurine, a corticosteroid, an alkylating agent, a calcineurin inhibitor, an inosine monophosphate dehydrogenase inhibitor, antilymphocyte globulin, antithymocyte globulin, an anti-T-cell antibody, or a combination thereof.", "In one embodiment, the antibody is infliximab.", "Embodiments of a method for treating an inflammatory bowel disease include diagnosing a subject as being in need of treatment for an inflammatory bowel disease an inflammatory bowel disease, administering to the subject a therapeutically effective amount of one or more compounds disclosed herein, and evaluating the subject to determine a future course of treatment.", "In some embodiments, the therapeutic amount is a daily dose of from about 1 mg/day up to about 2 grams/day.", "In one embodiment, a single compound is administered serially in plural administrations to the subject.", "In another embodiment, two or more compounds are administered either serially or in combination to the subject.", "In some embodiments, the one or more compounds are administered as a pharmaceutical composition.", "The pharmaceutical composition may include, in addition to the one or more compounds, an excipient, a second therapeutic, or both.", "In some embodiments, the one or more compounds are administered parenterally, orally, or rectally.", "In certain embodiments, the one or more compounds are administered prophylactically.", "Evaluating the subject to determine a future course of treatment may include determining a level of a biomarker associated with the inflammatory bowel disease.", "In some embodiments, the biomarker is a serologic biomarker, a genetic biomarker, a fecal biomarker, or a mucosal biomarker.", "The foregoing and other objects, features, and advantages of the invention will become more apparent from the following detailed description, which proceeds with reference to the accompanying figures.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS REFERENCE TO RELATED APPLICATION This application is a continuation of U.S. patent application Ser.", "No.", "14/750,794, filed on Jun.", "25, 2015, which is a continuation of Ser.", "No.", "14/163,822, filed Jan. 24, 2014, which claims the benefit of U.S.", "Provisional Application No.", "61/756,781, filed Jan. 25, 2013, all of which are incorporated herein in their entireties by reference.", "FIELD The present disclosure concerns pyrimidinediamine compounds and embodiments of a method for using the compounds to treat autoimmune diseases, such as inflammatory bowel diseases.", "BACKGROUND Inflammatory bowel diseases are a group of chronic inflammatory conditions that primarily affect the colon and small intestine.", "Inflammatory bowel diseases include, but are not limited to, Crohn's disease (also known as regional enteritis, Crohn's ileitis, and granulomatous colitis), collagenous colitis, granulomatous ileocolitis, idiopathic inflammatory bowel disease, ileitis, irritable bowel syndrome, lymphocytic colitis, regional enteritis, spastic colon, and ulcerative colitis.", "Common symptoms of inflammatory bowel diseases include intestinal inflammation (e.g., redness and/or swelling), abdominal pain, abdominal cramps, bloody diarrhea, vomiting, pelvic muscle spasms, and/or fever.", "Weight loss, sweats, malaise, and/or arthralgias also may occur.", "Inflammatory bowel disease symptoms typically wax and wane in intensity over time.", "Two of the most common inflammatory bowel diseases are ulcerative colitis and Crohn's disease.", "Ulcerative colitis is characterized by inflammation that is primarily limited to the mucosa and submucosa of the colon, or large intestine, and the rectum.", "Crohn's disease can cause inflammation anywhere throughout the digestive tract, and penetrates deeper into the tissues.", "In some cases, bowel inflammation results when the immune system attacks a pathogen, such as a virus or bacterium, or an intraluminal antigen, such as a protein from cow's milk.", "In other cases, inflammatory bowel disease may be an autoimmune process.", "Genetic predisposition also may have a role in certain cases.", "Inflammatory bowel disease can severely impact a subject's life, and current therapies frequently provide unsatisfactory and insufficient relief.", "SUMMARY This disclosure concerns compounds and embodiments of a method for treating and/or preventing inflammatory bowel diseases.", "In some embodiments, a method for treating a disease, such as an inflammatory bowel disease includes administering to a subject identified as having an inflammatory bowel disease, or being at risk of developing an inflammatory bowel disease, a therapeutically effective amount of a compound according to formula I wherein X and Y independently are O or NR1; each R1 is independently H or C1-C6 alkyl; ring A is aryl; each R2 independently is H, alkyl, alkoxy, amide, cyano, halo, haloalkyl, hydroxyalkyl, heteroalkyl, heterocyclyl, sulfonyl, sulfonamide, or two R2 groups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered ring system; p is 0, 1, 2, 3, or 4; R3 and R4 independently are H or C1-C6 alkyl; and R5 is halo, cyano, or C1-C6 alkyl.", "In some embodiments, ring A is phenyl.", "In certain embodiments, the compound has the formula wherein R1 is H or —CH2OP(O)(ONa)2, and R2a-R2c are as defined above for R2.In particular embodiments, the compound is selected from the group consisting of N2-(3,4,5-trimethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine; 4-[5-Methyl-4-(2-oxo-2,3-dihydro-benzooxazol-5-ylamino)-pyrimidin-2-ylamino]-N-phenyl-benzamide; N4-(benzo[d]oxazol-2(3H)-on-5-yl)-N2-(4-aminocarbonylphenyl)-5-methylpyrimidine-2,4-diamine; N2-(3,4-dimethyl-5-hydroxymethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine; N-Cyclobutyl-4-[5-methyl-4-(2-oxo-2,3-dihydro-benzooxazol-5-ylamino)-pyrimidin-2-ylamino]-benzamide; N4-(benzo[d]oxazol-2(3H)-on-5-yl)-N2-(3-methylsulfonyl)phenyl)-5-methylpyrimidine-2,4-diamine; 5-(2-(3-(fluoromethyl)-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)benzo[d]oxazol-2(3H)-one; N2-(3-fluoro-4-methyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine; N2-(3,5-dimethyl-4-hydroxymethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine; 5-[2-(3,4-Dimethyl-phenylamino)-5-methyl-pyrimidin-4-ylamino]-3H-benzooxazol-2-one; 5-(2-(3-chloro-4,5-dimethoxyphenylamino)-5-methylpyrimidin-4-ylamino)benzo[d]oxazol-2(3H)-one; 5-(2-(benzo[d]isoxazol-6-ylamino)-5-methylpyrimidin-4-ylamino)benzo[d]oxazol-2(3H)-one; N2-(3-methoxy-5-trifluoromethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine; N2-(3,5-dimethyl-4-fluoro)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine; N2-(3-methoxy-5-trifluoromethyl)phenyl-5-methyl-N4-[3-(phosphonooxy)methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl]-2,4-pyrimidinediamine bis-sodium salt; sodium (5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)-2-oxobenzo[d]oxazol-3(2H)-yl)methyl phosphate; 5-methyl-N4-[3-(phosphonooxy)methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl]-N2-(3,4,5-trimethyl)phenyl-2,4-pyrimidinediamine bis-sodium salt; and N2-(3,5-dimethyl-4-fluoro)phenyl-5-methyl-N4-[3-(phosphonooxy)methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl]-2,4-pyrimidinediamine bis-sodium salt.", "In some embodiments, the inflammatory bowel disease is Crohn's disease, collagenous colitis, granulomatous ileocolitis, idiopathic inflammatory bowel disease, ileitis, irritable bowel syndrome, lymphocytic colitis, regional enteritis, spastic colon, or ulcerative colitis.", "Administering the compound may include exposing to the subject to a first dose of the compound or a pharmaceutical composition comprising the compound.", "In some embodiments, the method further includes determining a therapeutic blood level of the compound or a metabolite thereof in the subject.", "The method may further include comparing the therapeutic blood level to a control, and adjusting a second dose of the compound, based at least in part on the comparison, to optimize therapeutic effect.", "For example, if the therapeutic blood level is greater than a control, the second dose may be decreased relative to the first dose.", "Alternatively, if the therapeutic blood level is less than a control, the second dose may be increased relative to the first dose.", "In certain embodiments, the therapeutically effective dose is in the range of from about 0.0001 mg/kg body weight/day to about 100 mg/kg/day, such as from about 5 mg/kg body weight/day to about 20 mg/kg/day.", "In one embodiment, the compound is administered serially in plural administrations to the subject.", "The method may include administering two or more compounds according to formula I serially or in combination to the subject.", "In some embodiments, the compound is administered as a pharmaceutical composition.", "The compound may be administered prophylactically.", "In some embodiments, the method further includes administering a second therapeutic to the subject.", "The second therapeutic may be administered in combination with the compound, or prior to or subsequent to the compound.", "In some embodiments, the second therapeutic is an analgesic, an antibiotic, an anticoagulant, an antibody, an anti-inflammatory agent, an immunosuppressant, a guanylate cyclase-C agonist, an intestinal secretagogue, or a combination thereof.", "The anti-inflammatory agent may be a steroid or a nonsteroidal anti-inflammatory agent.", "In certain embodiments, the nonsteroidal anti-inflammatory agent is selected from aminosalicylates, cyclooxygenase inhibitors, diclofenac, etodolac, famotidine, fenoprofen, flurbiprofen, ketoprofen, ketorolac, ibuprofen, indomethacin, meclofenamate, mefenamic acid, meloxicam, nambumetone, naproxen, oxaprozin, piroxicam, salsalate, sulindac, tolmetin, or a combination thereof.", "In some embodiments, the immunosuppressant is mercaptopurine, a corticosteroid, an alkylating agent, a calcineurin inhibitor, an inosine monophosphate dehydrogenase inhibitor, antilymphocyte globulin, antithymocyte globulin, an anti-T-cell antibody, or a combination thereof.", "In one embodiment, the antibody is infliximab.", "Embodiments of a method for treating an inflammatory bowel disease include diagnosing a subject as being in need of treatment for an inflammatory bowel disease an inflammatory bowel disease, administering to the subject a therapeutically effective amount of one or more compounds disclosed herein, and evaluating the subject to determine a future course of treatment.", "In some embodiments, the therapeutic amount is a daily dose of from about 1 mg/day up to about 2 grams/day.", "In one embodiment, a single compound is administered serially in plural administrations to the subject.", "In another embodiment, two or more compounds are administered either serially or in combination to the subject.", "In some embodiments, the one or more compounds are administered as a pharmaceutical composition.", "The pharmaceutical composition may include, in addition to the one or more compounds, an excipient, a second therapeutic, or both.", "In some embodiments, the one or more compounds are administered parenterally, orally, or rectally.", "In certain embodiments, the one or more compounds are administered prophylactically.", "Evaluating the subject to determine a future course of treatment may include determining a level of a biomarker associated with the inflammatory bowel disease.", "In some embodiments, the biomarker is a serologic biomarker, a genetic biomarker, a fecal biomarker, or a mucosal biomarker.", "The foregoing and other objects, features, and advantages of the invention will become more apparent from the following detailed description, which proceeds with reference to the accompanying figures.", "DETAILED DESCRIPTION I.", "Terms and Abbreviations Unless otherwise noted, technical terms are used according to conventional usage.", "As used herein, the singular terms “a,” “an,” and “the” include plural referents unless context clearly indicates otherwise.", "Similarly, the word “or” is intended to include “and” unless the context clearly indicates otherwise.", "Also, as used herein, the term “comprises” means “includes.” Hence “comprising A or B” means including A, B, or A and B.", "It is further to be understood that all molecular weight or molecular mass values, given compounds are approximate, and are provided for description.", "Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present disclosure, suitable methods and materials are described below.", "All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety.", "In case of conflict, the present specification, including explanations of terms, will control.", "In addition, the materials, methods, and examples are illustrative only and not intended to be limiting.", "When chemical structures are depicted or described, unless explicitly stated otherwise, all carbons are assumed to include hydrogen so that each carbon conforms to a valence of four.", "For example, in the structure on the left-hand side of the schematic below there are nine hydrogen atoms implied.", "The nine hydrogen atoms are depicted in the right-hand structure.", "Sometimes a particular atom in a structure is described in textual formula as having a hydrogen or hydrogen atoms, for example —CH2CH2—.", "It will be understood by a person of ordinary skill in the art that the aforementioned descriptive techniques are common in the chemical arts to provide brevity and simplicity to description of organic structures.", "In this application, some ring structures are depicted generically and will be described textually.", "For example, in the schematic below ring A may be used to describe a phenyl ring, a heteroaryl ring, such as a pyridine ring, and fused ring system.", "Again by way of example, if ring A is describes a phenyl ring, then there are four hydrogen atoms on ring A as well (when R is not H).", "If a group R is depicted as “floating” on a ring system, as for example in the following structure then, unless otherwise defined, R can reside on any atom of the bicyclic ring system, excluding the atom carrying the bond with the “” symbol, so long as a stable structure is formed.", "In the example depicted, the R group can reside on any depicted carbon atom in either the 5-membered or the 6-membered ring of the indolyl ring system.", "When there are more than one such depicted “floating” groups, as for example in the formulae where there are two groups, namely, the R and the bond indicating attachment to a parent structure, then, unless otherwise defined, the “floating” groups can reside on any atoms of the ring system, again assuming each replaces a depicted, implied, or expressly defined hydrogen on the ring system and a chemically stable compound would be formed by such connectivity.", "When a group R is depicted as existing on a ring system containing saturated carbons, as for example in the formula where, in this example, y can be more than one, assuming each replaces a currently depicted, implied, or expressly defined hydrogen on the ring, then, unless otherwise defined, two R's can reside on the same carbon.", "A simple example is when R is a methyl group, and the formula can depict geminal dimethyl groups bonded to a single carbon of the depicted ring (an “annular” carbon).", "In another example, two R's on the same carbon, including that same carbon, can form a ring, thus creating a spirocyclic ring (a “spirocyclyl” group) structure.", "Using the previous example, where two R's form, e.g.", "a piperidine ring in a spirocyclic arrangement with the cyclohexane, as for example in the formula When a group with its bonding structure is denoted as being bonded to two partners; that is, a divalent radical, for example, —OCH2—, then it is understood that either of the two partners can be bound to the particular group at one end, and the other partner is necessarily bound to the other end of the divalent group, unless stated explicitly otherwise.", "Stated another way, divalent radicals are not to be construed as limited to the depicted orientation, for example “—OCH2—” is meant to mean not only “—OCH2—” as drawn, but also “—CH2O—.” “Alkyl” in its broadest sense is intended to include linear, branched, or cyclic hydrocarbon structures, and combinations thereof.", "Alkyl groups can be fully saturated or with one or more units of unsaturation, but not aromatic.", "Generally alkyl groups are defined by a subscript, either a fixed integer or a range of integers.", "For example, “C8alkyl” includes n-octyl, iso-octyl, 3-octynyl, cyclohexenylethyl, cyclohexylethyl, and the like; where the subscript “8” designates that all groups defined by this term have a fixed carbon number of eight.", "In another example, the term “C1-6alkyl” refers to alkyl groups having from one to six carbon atoms and, depending on any unsaturation, branches and/or rings, the requisite number of hydrogens.", "Examples of C1-6alkyl groups include methyl, ethyl, vinyl, propyl, isopropyl, butyl, s-butyl, t-butyl, isobutyl, isobutenyl, pentyl, pentynyl, hexyl, cyclohexyl, hexenyl, and the like.", "When an alkyl residue having a specific number of carbons is named generically, all geometric isomers having that number of carbons are intended to be encompassed.", "For example, either “propyl” or “C3alkyl” each include n-propyl, c-propyl, propenyl, propynyl, and isopropyl.", "Cycloalkyl is a subset of alkyl and includes cyclic hydrocarbon groups of from three to thirteen carbon atoms.", "Examples of cycloalkyl groups include c-propyl, c-butyl, c-pentyl, norbornyl, norbornenyl, c-hexenyl, adamantyl and the like.", "As mentioned, alkyl refers to alkanyl, alkenyl, and alkynyl residues (and combinations thereof)—it is intended to include, e.g., cyclohexylmethyl, vinyl, allyl, isoprenyl, and the like.", "An alkyl with a particular number of carbons can be named using a more specific but still generic geometrical constraint, e.g.", "“C3-6cycloalkyl” which means only cycloalkyls having between 3 and 6 carbons are meant to be included in that particular definition.", "Unless specified otherwise, alkyl groups, whether alone or part of another group, e.g.", "—C(O)alkyl, have from one to twenty carbons, that is C1-20alkyl.", "In the example “—C(O)alkyl,” where there were no carbon count limitations defined, the carbonyl of the —C(O)alkyl group is not included in the carbon count, since “alkyl” is designated generically.", "But where a specific carbon limitation is given, e.g.", "in the term “optionally substituted C1-20alkyl,” where the optional substitution includes “oxo” the carbon of any carbonyls formed by such “oxo” substitution are included in the carbon count since they were part of the original carbon count limitation.", "However, again referring to “optionally substituted C1-20alkyl,” if optional substitution includes carbon-containing groups, e.g.", "—CH2CO2H, the two carbons in this group are not included in the C1-20alkyl carbon limitation.", "When a carbon number limit is given at the beginning of a term which itself comprises two terms, the carbon number limitation is understood as inclusive for both terms.", "For example, for the term “C7-14arylalkyl,” both the “aryl” and the “alkyl” portions of the term are included the carbon count, a maximum of 14 in this example, but additional substituent groups thereon are not included in the atom count unless they incorporate a carbon from the group's designated carbon count, as in the “oxo” example above.", "Likewise when an atom number limit is given, for example “6-14 membered heteroarylalkyl,” both the “heteroaryl” and the “alkyl” portion are included the atom count limitation, but additional substituent groups thereon are not included in the atom count unless they incorporate a carbon from the group's designated carbon count.", "In another example, “C4-10cycloalkylalkyl” means a cycloalkyl bonded to the parent structure via an alkylene, alkylidene or alkylidyne; in this example the group is limited to 10 carbons inclusive of the alkylene, alkylidene or alkylidyne subunit.", "As another example, the “alkyl” portion of, e.g.", "“C7-14arylalkyl” is meant to include alkylene, alkylidene or alkylidyne, unless stated otherwise, e.g.", "as in the terms “C7-14arylalkylene” or “C6-10aryl-CH2CH2—.” “Alkoxy” refers to the group —O-alkyl, where alkyl is as defined herein.", "Alkoxy includes, by way of example, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, t-butoxy, sec-butoxy, n-pentoxy, cyclohexyloxy, cyclohexenyloxy, cyclopropylmethyloxy, and the like.", "“Acyl” refers to the groups —C(O)H, —C(O)alkyl, —C(O)aryl and —C(O)heterocyclyl.", "“Amide” refers to the group —C(O)NH2 or —N(H)acyl.", "“Amino” refers to the group —NH2.“Aryl” (sometimes referred to as “Ar”) refers to a monovalent aromatic carbocyclic group of, unless specified otherwise, from 6 to 15 carbon atoms having a single ring (e.g., phenyl) or multiple condensed rings (e.g., naphthyl or anthryl) which condensed rings may or may not be aromatic (e.g., 2-benzoxazolinone, 2H-1,4-benzoxazin-3(4H)-one-7-yl, 9,10-dihydrophenanthrenyl, indanyl, tetralinyl, and fluorenyl and the like), provided that the point of attachment is through an atom of an aromatic portion of the aryl group and the aromatic portion at the point of attachment contains only carbons in the aromatic ring.", "If any aromatic ring portion contains a heteroatom, the group is a heteroaryl and not an aryl.", "Aryl groups are monocyclic, bicyclic, tricyclic or tetracyclic.", "“Arylalkyl” refers to a residue in which an aryl moiety is attached to a parent structure via one of an alkylene, alkylidene, or alkylidyne radical.", "Examples include benzyl, phenethyl, phenylvinyl, phenylallyl and the like.", "When specified as “optionally substituted,” both the aryl, and the corresponding alkylene, alkylidene, or alkylidyne portion of an arylalkyl group can be optionally substituted.", "By way of example, “C7-11arylalkyl” refers to an arylalkyl limited to a total of eleven carbons, e.g., a phenylethyl, a phenylvinyl, a phenylpentyl and a naphthylmethyl are all examples of a “C7-11arylalkyl” group.", "“Arylene” refers to an aryl that has at least two groups attached thereto.", "For a more specific example, “phenylene” refers to a divalent phenyl ring radical.", "A phenylene, thus can have more than two groups attached, but is defined by a minimum of two non-hydrogen groups attached thereto.", "“Aryloxy” refers to the group —O-aryl, where aryl is as defined herein, including, by way of example, phenoxy, naphthoxy, and the like.", "“Autoimmune Disease” refers to those diseases which are commonly associated with the nonanaphylactic hypersensitivity reactions (Type II, Type III and/or Type IV hypersensitivity reactions) that generally result as a consequence of the subject's own humoral and/or cell-mediated immune response to one or more immunogenic substances of endogenous and/or exogenous origin.", "Such autoimmune diseases are distinguished from diseases associated with the anaphylactic (Type I or IgE-mediated) hypersensitivity reactions.", "“Carboxyl,” “carboxy” or “carboxylate” refers to —CO2H or salts thereof.", "“Carboxyl ester” or “carboxy ester” or “ester” refers to the group —CO2alkyl, —CO2aryl or —CO2heterocyclyl.", "“Carbamate” refers to the group —OC(O)NH2, —N(H)carboxyl or —N(H)carboxyl ester.", "“Carbonate” refers to the group —OCO2alkyl, —OCO2aryl or —OCO2heterocyclyl.", "“Cyano” or “nitrile” refers to the group —CN.", "“Halo” or “halogen” refers to fluoro, chloro, bromo and iodo.", "“Haloalkyl” and “haloaryl” refer generically to alkyl and aryl radicals that are substituted with one or more halogens, respectively.", "By way of example “dihaloaryl,” “dihaloalkyl,” “trihaloaryl” etc.", "refer to aryl and alkyl substituted with a plurality of halogens, but not necessarily a plurality of the same halogen; thus 4-chloro-3-fluorophenyl is a dihaloaryl group.", "“Haloalkyloxy” refers to the group —O-alkyl, where alkyl is as defined herein, and further, alkyl is substituted with one or more halogens.", "By way of example, a haloC1-3alkyloxy” group includes —OCF3, —OCF2H, —OCHF2, —OCH2CH2Br, —OCH2CH2CH2I, —OC(CH3)2Br, —OCH2Cl and the like.", "“Heteroalkyl” refers to an alkyl where one or more, but not all, carbons are replaced with a heteroatom.", "A heteroalkyl group has either linear or branched geometry.", "By way of example, a “2-6 membered heteroalkyl” is a group that can contain no more than 5 carbon atoms, because at least one of the maximum 6 atoms must be a heteroatom, and the group is linear or branched.", "Also, for the purposes of this invention, a heteroalkyl group always starts with a carbon atom, that is, although a heteroalkyl may contain one or more heteroatoms, the point of attachment to the parent molecule is not a heteroatom.", "A 2-6 membered heteroalkyl group includes, for example, —CH2XCH3, —CH2CH2XCH3, —CH2CH2XCH2CH3, —C(CH2)2XCH2CH3 and the like, where X is O, NH, NC1-6alkyl and S(O)0-2, for example.", "“Heteroaryl” refers to an aromatic group having from 1 to 10 annular carbon atoms and 1 to 4 annular heteroatoms.", "Heteroaryl groups have at least one aromatic ring component, but heteroaryls can be fully unsaturated or partially unsaturated.", "If any aromatic ring in the group has a heteroatom, then the group is a heteroaryl, even, for example, if other aromatic rings in the group have no heteroatoms.", "For example, 2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one-7-yl, indolyl and benzimidazolyl are “heteroaryls.” Heteroaryl groups can have a single ring (e.g., pyridinyl, imidazolyl or furyl) or multiple condensed rings (e.g., indolizinyl, quinolinyl, benzimidazolyl or benzothienyl), where the condensed rings may or may not be aromatic and/or contain a heteroatom, provided that the point of attachment to the parent molecule is through an atom of the aromatic portion of the heteroaryl group.", "In one embodiment, the nitrogen and/or sulfur ring atom(s) of the heteroaryl group are optionally oxidized to provide for the N-oxide (N→O), sulfinyl, or sulfonyl moieties.", "Compounds described herein containing phosphorous, in a heterocyclic ring or not, include the oxidized forms of phosphorous.", "Heteroaryl groups are monocyclic, bicyclic, tricyclic or tetracyclic.", "“Heteroarylene” generically refers to any heteroaryl that has at least two groups attached thereto.", "For a more specific example, “pyridylene” refers to a divalent pyridyl ring radical.", "A pyridylene, thus can have more than two groups attached, but is defined by a minimum of two non-hydrogen groups attached thereto.", "“Heteroaryloxy” refers to —O-heteroaryl.", "“Heteroatom” refers to O, S, N, or P. “Heterocyclyl” in the broadest sense includes aromatic and non-aromatic ring systems and more specifically refers to a stable three- to fifteen-membered ring radical that consists of carbon atoms and from one to five heteroatoms.", "For purposes of this invention, the heterocyclyl radical can be a monocyclic, bicyclic or tricyclic ring system, which can include fused or bridged ring systems as well as spirocyclic systems; and the nitrogen, phosphorus, carbon or sulfur atoms in the heterocyclyl radical can be optionally oxidized to various oxidation states.", "In a specific example, the group —S(O)0-2-, refers to —S— (sulfide), —S(O)— (sulfoxide), and —SO2— (sulfone) linkages.", "For convenience, nitrogens, particularly but not exclusively, those defined as annular aromatic nitrogens, are meant to include their corresponding N-oxide form, although not explicitly defined as such in a particular example.", "Thus, for a compound having, for example, a pyridyl ring; the corresponding pyridyl-N-oxide is meant to be included in the presently disclosed compounds.", "In addition, annular nitrogen atoms can be optionally quaternized.", "“Heterocycle” includes heteroaryl and heteroalicyclyl, that is a heterocyclic ring can be partially or fully saturated or aromatic.", "Thus a term such as “heterocyclylalkyl” includes heteroalicyclylalkyls and heteroarylalkyls.", "Examples of heterocyclyl radicals include, but are not limited to, azetidinyl, acridinyl, benzodioxolyl, benzodioxanyl, benzofuranyl, carbazoyl, cinnolinyl, dioxolanyl, indolizinyl, naphthyridinyl, perhydroazepinyl, phenazinyl, phenothiazinyl, phenoxazinyl, phthalazinyl, pteridinyl, purinyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, tetrazoyl, tetrahydroisoquinolyl, piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, 2-oxoazepinyl, azepinyl, pyrrolyl, 4-piperidonyl, pyrrolidinyl, pyrazolyl, pyrazolidinyl, imidazolyl, imidazolinyl, imidazolidinyl, dihydropyridinyl, tetrahydropyridinyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, oxazolyl, oxazolinyl, oxazolidinyl, triazolyl, isoxazolyl, isoxazolidinyl, morpholinyl, thiazolyl, thiazolinyl, thiazolidinyl, isothiazolyl, quinuclidinyl, isothiazolidinyl, indolyl, isoindolyl, indolinyl, isoindolinyl, octahydroindolyl, octahydroisoindolyl, quinolyl, isoquinolyl, decahydroisoquinolyl, benzimidazolyl, thiadiazolyl, benzopyranyl, benzothiazolyl, benzoxazolyl, furyl, diazabicycloheptane, diazapane, diazepine, tetrahydrofuryl, tetrahydropyranyl, thienyl, benzothieliyl, thiamorpholinyl, thiamorpholinyl sulfoxide, thiamorpholinyl sulfone, dioxaphospholanyl, and oxadiazolyl.", "“Heterocyclylalkyl” refers to a heterocyclyl group linked to the parent structure via, e.g., an alkylene linker, for example (tetrahydrofuran-3-yl)methyl- or (pyridin-4-yl)methyl “Heterocyclyloxy” refers to the group —O-heterocycyl.", "“Hydroxy” or “hydroxyl” refers to the group —OH.", "“Hydroxyalkyl” refers to a hydroxy-substituted alkyl group, e.g., —(CH2)xOH.", "“JAK inhibitor” refers to a compound that inhibits at least one member of the Janus kinase family.", "The Janus kinase (JAK) family is a recognized family of non-receptor tyrosine kinases.", "Mammals have four members of this family, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2).", "Phosphorylated JAK kinases bind various STAT (Signal Transducer and Activator of Transcription) proteins.", "STAT proteins, which are DNA binding proteins activated by phosphorylation of tyrosine residues, function both as signaling molecules and transcription factors and ultimately bind to specific DNA sequences present in the promoters of cytokine-responsive genes (Leonard et al., (2000), J.", "Allergy Clin.", "Immunol.", "105:877-888).", "JAK/STAT signaling has been implicated in the mediation of many abnormal immune responses.", "Studies suggest that JAK3 associates with the common gamma (γc) chain of the various cytokine receptors.", "JAK3 in particular selectively binds to receptors and is part of the cytokine signaling pathway for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21.JAK1 interacts with, among others, the receptors for cytokines IL-2, IL-4, IL-7, IL-9, IL-13 and IL-21, while JAK2 interacts with, among others, the receptors for IL-9, IL-13 and TNF-α.", "Methods for determining JAK inhibition are well known in the art and can be performed, for example, using kits or services commercially available from Ambit Biosciences, Invitrogen and others.", "Typically JAK inhibitors described herein have an IC50 for at least one member of the JAK family of less than about 10 μM, such as less than 5 μM, such as up to about 1 μM or less than about 100 nM.", "“Metabolite” refers to the break-down or end product of a compound or its salt produced by metabolism or biotransformation in the animal or human body; for example, biotransformation to a more polar molecule such as by oxidation, reduction, or hydrolysis, or to a conjugate (see Goodman and Gilman, “The Pharmacological Basis of Therapeutics” 12th Ed., Pergamon Press, Gilman et al.", "(eds), 1990 which is herein incorporated by reference).", "The metabolite of a compound described herein or its salt can itself be a biologically active compound in the body.", "While a prodrug described herein would meet this criteria, that is, form a described biologically active parent compound in vivo, “metabolite” is meant to encompass those compounds not contemplated to have lost a progroup, but rather all other compounds that are formed in vivo upon administration of a compound of the invention which retain the biological activities described herein.", "Thus one aspect disclosed compounds specifically contemplated herein is a metabolite of a compound described herein.", "For example, a biologically active metabolite is discovered serendipitously, that is, no prodrug design per se was undertaken.", "Stated another way, biologically active compounds inherently formed as a result of practicing methods of the invention, are contemplated and disclosed herein.", "“Nitro” refers to the group —NO2.“Optional” or “optionally” means that the subsequently described event or circumstance may or may not occur, and that the description includes instances where said event or circumstance occurs and instances in which it does not.", "One of ordinary skill in the art would understand that, with respect to any molecule described as containing one or more optional substituents, that only synthetically feasible compounds are meant to be included.", "“Optionally substituted” refers to all subsequent modifiers in a term, for example in the term “optionally substituted arylC1-8alkyl,” optional substitution may occur on both the “C1-8alkyl” portion and the “aryl” portion of the arylC1-8alkyl group.", "Also by way of example, optionally substituted alkyl includes optionally substituted cycloalkyl groups.", "The term “substituted,” when used to modify a specified group or radical, means that one or more hydrogen atoms of the specified group or radical are each, independently of one another, replaced with the same or different substituent groups as defined below.", "Thus, when a group is defined as “optionally substituted” the definition is meant to encompass when the groups is substituted with one or more of the radicals defined below, and when it is not so substituted.", "“Oxo” refers to a double bond oxygen radical, ═O.", "“Oxy” refers to —O.", "radical (also designated as →O), that is, a single bond oxygen radical.", "By way of example, N-oxides are nitrogens bearing an oxy radical.", "“Patient” or “Subject” refers to mammals and other animals, particularly humans.", "Thus the methods are applicable to both human therapy and veterinary applications.", "In one embodiment the patient or subject is a mammal.", "In another embodiment the patient or subject is a human.", "“Perhalo” as a modifier means that the group so modified has all its available hydrogens replaced with halogens.", "An example would be “perhaloalkyl.” Perhaloalkyls include —CF3, —CF2CF3, perchloroethyl and the like.", "“Pharmaceutically acceptable salt” refers to pharmaceutically acceptable salts of a compound, which salts are derived from a variety of organic and inorganic counter ions well known in the art and include, by way of example only, sodium, potassium, calcium, magnesium, ammonium, tetraalkylammonium, and the like; and when the molecule contains a basic functionality, salts of organic or inorganic acids, such as hydrochloride, hydrobromide, tartrate, mesylate, acetate, maleate, oxalate, and the like.", "Pharmaceutically acceptable acid addition salts are those salts that retain the biological effectiveness of the free bases while formed by acid partners that are not biologically or otherwise undesirable, e.g., inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like, as well as organic acids such as acetic acid, trifluoroacetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid and the like.", "Pharmaceutically acceptable base addition salts include those derived from inorganic bases such as sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts and the like.", "Exemplary salts are the ammonium, potassium, sodium, calcium, and magnesium salts.", "Salts derived from pharmaceutically acceptable organic non-toxic bases include, but are not limited to, salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, ethanolamine, 2-dimethylaminoethanol, 2-diethylaminoethanol, dicyclohexylamine, lysine, arginine, histidine, caffeine, procaine, hydrabamine, choline, betaine, ethylenediamine, glucosamine, methylglucamine, theobromine, purines, piperazine, piperidine, N-ethylpiperidine, polyamine resins, and the like.", "Exemplary organic bases are isopropylamine, diethylamine, ethanolamine, trimethylamine, dicyclohexylamine, choline, and caffeine.", "(See, for example, S. M. Berge, et al., “Pharmaceutical Salts,” J. Pharm.", "Sci., 1977; 66:1-19, which is incorporated herein by reference.)", "Additional examples of suitable salts, without limitation, include citrate salts and xinafoate salts.", "“Pharmaceutically effective amount” and “therapeutically effective amount” refer to an amount of a compound sufficient to treat a specified disorder or disease or one or more of its symptoms and/or to prevent the occurrence of the disease or disorder.", "The amount of a compound which constitutes a “therapeutically effective amount” will vary depending on the compound, the disease state and its severity, the age of the subject to be treated, and the like.", "The therapeutically effective amount can be determined routinely by one of ordinary skill in the art.", "“Prodrug” refers to compounds that are transformed in vivo to yield the parent compound, for example, by hydrolysis in the gut or enzymatic conversion in blood.", "The prodrug includes at least one functional group masked with a progroup or promoiety, which may be cleaved under conditions of use.", "Common examples include, but are not limited to, ester and amide forms of a compound having an active form bearing a carboxylic acid moiety.", "Examples of pharmaceutically acceptable esters of the compounds of this invention include, but are not limited to, alkyl esters (for example with between about one and about six carbons) where the alkyl group is a straight or branched chain, and phosphates.", "Acceptable esters also include cycloalkyl esters and arylalkyl esters such as, but not limited to benzyl.", "Examples of pharmaceutically acceptable amides of the compounds of this invention include, but are not limited to, primary amides, and secondary and tertiary alkyl amides (for example with between about one and about six carbons).", "Amides and esters of the compounds of the present invention can be prepared according to conventional methods.", "A thorough discussion of prodrugs is provided in T. Higuchi and V. Stella, “Pro-drugs as Novel Delivery Systems,” Vol 14 of the A.C.S.", "Symposium Series, and in Bioreversible Carriers in Drug Design, ed.", "Edward B. Roche, American Pharmaceutical Association and Pergamon Press, 1987, both of which are incorporated herein by reference for all purposes.", "“Second Therapeutic (Agent)” as used herein concerns any additional compound, drug, or formulation that can be used with disclosed embodiments of the compound described here, particularly those agents used to aid in ventilating a subject.", "Particular examples of a second therapeutic agents are disclosed herein.", "“Solvate” refers to a complex formed by combination of solvent molecules with molecules or ions of the solute.", "The solvent can be an organic compound, an inorganic compound, or a mixture of both.", "Some examples of solvents include, but are not limited to, methanol, N,N-dimethylformamide, tetrahydrofuran, dimethylsulfoxide, and water.", "The compounds described herein can exist in unsolvated as well as solvated forms with solvents, pharmaceutically acceptable or not, such as water, ethanol, and the like.", "Solvated forms of the presently disclosed compounds are contemplated herein and are encompassed by the invention, at least in generic terms.", "“Stereoisomer” and “stereoisomers” refer to compounds that have the same atomic connectivity but different atomic arrangement in space.", "Stereoisomers include cis-trans isomers, E and Z isomers, enantiomers and diastereomers.", "Compounds of the invention, or their pharmaceutically acceptable salts can contain one or more asymmetric centers and can thus give rise to enantiomers, diastereomers, and other stereoisomeric forms that can be defined, in terms of absolute stereochemistry, as (R)- or (S)- or, as (D)- or (L)- for amino acids.", "The present invention is meant to include all such possible isomers, as well as their racemic and optically pure forms.", "Optically active (+) and (−), (R)- and (S)-, or (D)- and (L)- isomers can be prepared using chiral synthons, chiral reagents, or resolved using conventional techniques, such as by: formation of diastereoisomeric salts or complexes which can be separated, for example, by crystallization; via formation of diastereoisomeric derivatives which can be separated, for example, by crystallization, selective reaction of one enantiomer with an enantiomer-specific reagent, for example enzymatic oxidation or reduction, followed by separation of the modified and unmodified enantiomers; or gas-liquid or liquid chromatography in a chiral environment, for example on a chiral support, such as silica with a bound chiral ligand or in the presence of a chiral solvent.", "It will be appreciated that where a desired enantiomer is converted into another chemical entity by one of the separation procedures described above, a further step may be required to liberate the desired enantiomeric form.", "Alternatively, specific enantiomer can be synthesized by asymmetric synthesis using optically active reagents, substrates, catalysts or solvents, or by converting on enantiomer to the other by asymmetric transformation.", "For a mixture of enantiomers, enriched in a particular enantiomer, the major component enantiomer can be further enriched (with concomitant loss in yield) by recrystallization.", "When the compounds described herein contain olefinic double bonds or other centers of geometric asymmetry, and unless specified otherwise, it is intended that the compounds include both E and Z geometric isomers.", "A “substituent” is an atom or group of atoms that replaces another atom in a molecule as the result of a reaction.", "The term “substituent” typically refers to an atom or group of atoms that replaces a hydrogen atom on a parent hydrocarbon chain or ring.", "Unless stated explicitly otherwise, all functional groups described herein may be unsubstituted or substituted with one or more substituent groups.", "For example, the term “alkyl” refers to both substituted and unsubstituted alkyl groups.", "Substituent groups for substituting for one or more hydrogens (any two hydrogens on a single carbon can be replaced with ═O, ═NR70, ═N—OR70, ═N2 or ═S) on saturated carbon atoms in the specified group or radical are, unless otherwise specified, —R60, halo, ═O, —OR70, —SR70, —N(R80)2, perhaloalkyl, —CN, —OCN, —SCN, —NO, —NO2, ═N2, —N3, —SO2R70, —SO3−M+, —SO3R70, —OSO2R70, —OSO3−M+, —OSO3R70, —OP(O)(O−)2(M+)2, —OP(O)(O−)2M2+, —OP(O)(OR70)O−M+, —OP(O)(OR70)2, —P(O)(O−)2(M+)2, —P(O)(O−)2M2+, —P(O)(OR70)O−M+, —P(O)(OR70)2, —C(O)R70, —C(S)R70, —C(NR70)R70, —CO2−M+, —CO2R70, —C(S)OR70, —C(O)N(R80)2, —C(NR70)(R80)2, —OC(O)R70, —OC(S)R70, —OCO2−M+, —OCO2R70, —OC(S)OR70, —NR70C(O)R70, —NR70C(S)R70, —NR70CO2−M+, —NR70CO2R70, —NR70C(S)OR70, —NR70C(O)N(R80)2, —NR70C(NR70)R70 and —NR70C(NR70)N(R80)2, where R60 is C1-6alkyl, 3 to 10-membered heterocyclyl, 3 to 10-membered heterocyclylC1-6alkyl, C6-10aryl or C6-10arylC1-6alkyl; each R70 is independently for each occurrence hydrogen or R60; each R80 is independently for each occurrence R70 or alternatively, two R80′s, taken together with the nitrogen atom to which they are bonded, form a 3 to 7-membered heteroalicyclyl which optionally includes from 1 to 4 of the same or different additional heteroatoms selected from O, N and S, of which N optionally has H or C1-C3alkyl substitution; and each M+ is a counter ion with a net single positive charge.", "Each M+ is independently for each occurrence, for example, an alkali ion, such as K+, Na+, Li+; an ammonium ion, such as +N(R60)4; or an alkaline earth ion, such as [Ca2+]0.5, [Mg2+]0.5, or [Ba2+]0.5 (a “subscript 0.5 means e.g.", "that one of the counter ions for such divalent alkali earth ions can be an ionized form of a compound of the invention and the other a typical counter ion such as chloride, or two ionized compounds can serve as counter ions for such divalent alkali earth ions, or a doubly ionized compound can serve as the counter ion for such divalent alkali earth ions).", "As specific examples, —N(R80)2 is meant to include —NH2, —NH-alkyl, —NH-pyrrolidin-3-yl, N-pyrrolidinyl, N-piperazinyl, 4N-methyl-piperazin-1-yl, N-morpholinyl and the like.", "Substituent groups for replacing hydrogens on unsaturated carbon atoms in groups containing unsaturated carbons are, unless otherwise specified, —R60, halo, —O−M+, —OR70, —SR70, —S−M+, —N(R80)2, perhaloalkyl, —CN, —OCN, —SCN, —NO, —NO2, —N3, —SO2R70, —SO3−M+, —SO3R70, —OSO2R70, —OSO3−M+, —OSO3R70, —PO3−2(M+)2, —PO3−2M2+, —P(O)(OR70)O−M+, —P(O)(OR70)2, —C(O)R70, —C(S)R70, —C(NR70)R70, —CO2−M+, —CO2R70, —C(S)OR70, —C(O)NR80R80, —C(NR70)N(R80)2, —OC(O)R70, —OC(S)R70, —OCO2−M+, —OCO2R70, —OC(S)OR70, —NR70C(O)R70, —NR70C(S)R70, —NR70CO2−M+, —NR70CO2R70, —NR70C(S)OR70, —NR70C(O)N(R80)2, —NR70C(NR70)R70 and —NR70C(NR70)N(R80)2, where R60, R70, R80 and M+ are as previously defined, provided that in case of substituted alkene or alkyne, the substituents are not —O−M+, —OR70, —SR70, or —S−M+.", "Substituent groups for replacing hydrogens on nitrogen atoms in groups containing such nitrogen atoms are, unless otherwise specified, —R60, —O−M+, —OR70, —SR70, —S−M+, —N(R80)2, perhaloalkyl, —CN, —NO, —NO2, —S(O)2R70, —SO3−M+, —SO3R70, —OS(O)2R70, —OSO3−M+, —OSO3R70, —PO32−(M+)2, —PO32−M2+, —P(O)(OR70)O−M+, —P(O)(OR70)(OR70), —C(O)R70, —C(S)R70, —C(NR70)R70, —CO2R70, —C(S)OR70, —C(O)NR80R80, —C(NR70)NR80R80, —OC(O)R70, —OC(S)R70, —OC2R70, —OC(S)OR70, —NR70C(O)R70, —NR70C(S)R70, —NR70CO2R70, —NR70C(S)OR70, —NR70C(O)N(R80)2, —NR70C(NR70)R70 and —NR70C(NR70)N(R80)2, where R60, R70, R80 and M+ are as previously defined.", "In one embodiment, a group that is substituted has 1, 2, 3, or 4 substituents, 1, 2, or 3 substituents, 1 or 2 substituents, or 1 substituent.", "It is understood that in all substituted groups, polymers arrived at by defining substituents with further substituents to themselves (e.g., substituted aryl having a substituted aryl group as a substituent which is itself substituted with a substituted aryl group, which is further substituted by a substituted aryl group, etc.)", "are not intended for inclusion herein.", "In such case that the language permits such multiple substitutions, the maximum number of such iterations of substitution is three.", "“Suitable leaving group” is defined as the term would be understood by one of ordinary skill in the art; that is, a group on a carbon, where upon reaction a new bond is to be formed, the carbon loses the group upon formation of the new bond.", "A typical example employing a suitable leaving group is a nucleophilic substitution reaction, e.g., on a sp3 hybridized carbon (SN2 or SN1), e.g.", "where the leaving group is a halide, such as a bromide, the reactant might be benzyl bromide.", "Another typical example of such a reaction is a nucleophilic aromatic substitution reaction (SNAr).", "Another example is an insertion reaction (for example by a transition metal) into the bond between an aromatic reaction partner bearing a leaving group followed by reductive coupling.", "“Suitable leaving group” is not limited to such mechanistic restrictions.", "Examples of suitable leaving groups include halogens, optionally substituted aryl or alkyl sulfonates, phosphonates, azides and —S(O)0-2R where R is, for example optionally substituted alkyl, optionally substituted aryl, or optionally substituted heteroaryl.", "Those of skill in the art of organic synthesis will readily identify suitable leaving groups to perform a desired reaction under different reaction.", "“Sulfonamide” refers to the group —SO2NH2, —N(H)SO2H, —N(H)SO2alkyl, —N(H)SO2aryl, or —N(H)SO2heterocyclyl.", "“Sulfonyl” refers to the group —SO2H, —SO2alkyl, —SO2aryl, or —SO2heterocyclyl.", "“Sulfanyl” refers to the group: —SH, —S-alkyl, —S-aryl, or —S-heterocyclyl.", "“Sulfinyl” refers to the group: —S(O)H, —S(O)alkyl, —S(O)aryl or —S(O)heterocyclyl.", "“Tautomer” refers to alternate forms of a molecule that differ only in electronic bonding of atoms and/or in the position of a proton, such as enol-keto and imine-enamine tautomers, or the tautomeric forms of heteroaryl groups containing a —N═C(H)—NH— ring atom arrangement, such as pyrazoles, imidazoles, benzimidazoles, triazoles, and tetrazoles.", "A person of ordinary skill in the art would recognize that other tautomeric ring atom arrangements are possible and contemplated herein.", "“Treating” or “treatment” as used herein covers the treatment of the disease or condition of interest in a mammal, preferably a human, having the disease or condition of interest, and includes: (i) preventing the disease or condition from occurring in a mammal, in particular, when such mammal is predisposed to the condition but has not yet been diagnosed as having it; (ii) inhibiting the disease or condition, for example, arresting or slowing its development; (iii) relieving the disease or condition, for example, causing regression of the disease or condition or a symptom thereof; or (iv) stabilizing the disease or condition.", "As used herein, the terms “disease” and “condition” can be used interchangeably or can be different in that the particular malady or condition may not have a known causative agent (so that etiology has not yet been worked out) and it is therefore not yet recognized as a disease but only as an undesirable condition or syndrome, where a more or less specific set of symptoms have been identified by clinicians.", "Similarly, it is understood that the above definitions are not intended to include impermissible substitution patterns (e.g., methyl substituted with 5 fluoro groups).", "Such impermissible substitution patterns are easily recognized by a person having ordinary skill in the art.", "II.", "Autoimmune Diseases Autoimmune diseases result from an inappropriate immune response, and may involve tissue injury that occurs as a result of a humoral and/or cell-mediated response to immunogens or antigens of endogenous and/or exogenous origin.", "JAK inhibitors, such as the 2,4-substituted pyrimidinediamine compounds described herein, can be used to treat and/or prevent certain autoimmune diseases, such as Hashimoto's thyroiditis, autoimmune hemolytic anemia, autoimmune atrophic gastritis of pernicious anemia, autoimmune encephalomyelitis, autoimmune orchitis, Goodpasture's disease, autoimmune thrombocytopenia, sympathetic ophthalmia, myasthenia gravis, Graves' disease, primary biliary cirrhosis, chronic aggressive hepatitis, membranous glomerulopathy, Reiter's syndrome, polymyositis-dermatomyositis, systemic sclerosis, polyarteritis nodosa, multiple sclerosis, bullous pemphigoid, Cogan's syndrome, ankylosing spondylitis, Wegener's granulomatosis, autoimmune alopecia, and inflammatory bowel diseases, such as Crohn's disease, collagenous colitis, granulomatous ileocolitis, idiopathic inflammatory bowel disease, ileitis, irritable bowel syndrome, lymphocytic colitis, regional enteritis, spastic colon, and ulcerative colitis.", "In particular embodiments, the methods may be used to treat or prevent inflammatory bowel diseases, such as Crohn's disease, collagenous colitis, granulomatous ileocolitis, idiopathic inflammatory bowel disease, ileitis, irritable bowel syndrome, lymphocytic colitis, regional enteritis, spastic colon, and ulcerative colitis.", "In some examples, the inflammatory bowel disease is ulcerative colitis, Crohn's disease, lymphocytic colitis, or collagenous colitis.", "It will be appreciated by skilled artisans that many of the above-listed diseases are associated with severe symptoms, the amelioration of which provides significant therapeutic benefit even in instances where the underlying disease may not be ameliorated.", "III.", "Compounds and Compositions Thereof A.", "Compounds The present disclosure concerns compounds capable of treating and/or preventing certain diseases, such as inflammatory bowel diseases.", "Embodiments of the disclosed compounds are JAK inhibitors.", "Because JAK3 is required for immune cell development, targeting JAK3 is a useful strategy for treating inflammatory bowel diseases.", "The selectivity of JAK3 inhibitors has advantages over currently used drugs, which have many biological targets and diverse side effects.", "The compounds, and other forms thereof, including, by way of example and without limitation, salts, hydrates, solvates, N-oxides and prodrugs, described herein are generally 2,4-pyrimidinediamines.", "Certain disclosed compounds are pyrimidinediamines substituted at the 5-position with various groups; substituted at the 2-amine with various aromatic groups; and/or substituted at the 4-amine with heteroaryl groups, such as a heterobicyclic group, exemplified by benzo[d]oxazol-2(3H)-one, which itself may comprise one or more groups, including prodrug moieties, as described herein.", "More specifically, exemplary disclosed compounds are described in terms of formula I: With reference to formula I, X and Y independently are heteroatoms or heteroatom-containing groups, particularly O or NR1; each R1 is independently H or alkyl, particularly lower alkyl, such as C1-C6 alkyl; ring A is aryl, such as phenyl, heteroaryl, such as pyridyl, or a fused ring system, such as, by way of example, an indazole ring system; each R2 independently is H, alkyl, alkoxy, amide, cyano, halo, haloalkyl, hydroxyalkyl, heteroalkyl, heterocyclyl, sulfonyl, sulfonamide, or two R2 groups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered ring system, such as a partially or fully saturated monocyclic ring, or ring system comprising two or more ring systems, including bicyclic ring systems, tricyclic ring systems, and the like, and particularly including fused ring systems, such as bicyclic fused ring systems; p is 0, 1, 2, 3 or 4, more typically 1, 2 or 3; R3 and R4 independently are selected from H and alkyl, particularly lower alkyl, such as C1-C6 alkyl, and more typically methyl; and R5 is selected from halo, particularly fluoro, cyano, and alkyl, particularly lower alkyl, such as C1-C6 alkyl, and more typically methyl.", "In some embodiments according to structural formula I, ring A is a phenyl.", "In certain embodiments, ring A is phenyl with at least one R2 group para or meta to N2 of the pyrimidinediamine, or ring A is phenyl and two R2 groups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered bicyclic ring system with ring A.", "As mentioned, certain presently disclosed compounds have structural formula I where ring A is phenyl, including phenyl optionally substituted with one or more R2 groups, each of which are optionally substituted with one or more groups.", "Thus, in one embodiment, disclosed compounds have formula II: With reference to formula II, R2a, R2b, and R2c independently are H, alkyl, alkoxy, amide, cyano, halo, haloalkyl, hydroxyalkyl, heteroalkyl, heterocyclyl, sulfonyl, sulfonamide, or two of the R2a-c groups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered ring system, such as a partially or fully saturated monocyclic ring, or ring system comprising two or more ring systems, including bicyclic ring systems, tricyclic ring systems, and the like, and particularly including fused ring systems, such as bicyclic fused ring systems; and R5 is selected from halo, particularly fluoro, cyano, and alkyl, such as C1-C6 alkyl, and more typically methyl.", "In other embodiments, the compound may have a formula III: With reference to formula III, R2a, R2b, and R2c independently are H, alkyl, alkoxy, amide, cyano, halo, haloalkyl, hydroxyalkyl, heteroalkyl, heterocyclyl, sulfonyl, sulfonamide, or two R2a-c groups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered ring system, such as a partially or fully saturated monocyclic ring, or ring system comprising two or more ring systems, including bicyclic ring systems, tricyclic ring systems, and the like, and particularly including fused ring systems, such as bicyclic fused ring systems; and R5 is halo, particularly fluoro, cyano, and alkyl, such as C1-C6 alkyl, and more typically methyl.", "In particular embodiments, R2a and R2c independently are H and R2b is an amide.", "In other disclosed embodiments, R2a and R2b independently are H and R2c is selected from sulfonamide, sulfonyl, and heteroalkyl.", "In certain embodiments, the compound may be a prodrug according to formula IV: With reference to formula IV, R1 is a progroup, such as —CH2OP(O)(ONa)2; R2a, R2b, and R2c independently are H, alkyl, alkoxy, amide, cyano, halo, haloalkyl, hydroxyalkyl, heteroalkyl, heterocyclyl, sulfonyl, sulfonamide, or two R2a-c groups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered ring system, such as a partially or fully saturated monocyclic ring, or ring system comprising two or more ring systems, including bicyclic ring systems, tricyclic ring systems, and the like, and particularly including fused ring systems, such as bicyclic fused ring systems; and R5 is halo, particularly fluoro, cyano, and alkyl, such as C1-C6 alkyl, and more typically methyl.", "A person of ordinary skill in the art will recognize that any one of the groups described herein for the general formulas may be substituted with one or more substituents.", "The term “substituted” means that one or more hydrogen atoms of the specified group or radical are each, independently of one another, replaced with the same or different substituent groups as defined in the definitions section for “substituent groups for substituting for one or more hydrogen atoms.” The presently disclosed compounds can exist as the parent compound, or a prodrug or pharmaceutically acceptable salt thereof, all of which can be in the form of hydrates, solvates, and N-oxides, as will be understood by a person or ordinary skill in the art.", "One embodiment is a pharmaceutically acceptable salt form of a compound of formula I.", "The pharmaceutically acceptable salts of the present invention can be formed by any acceptable method such as, by way of example: reacting the free base form of the product with one or more equivalents of the appropriate acid in a solvent or medium in which the salt is insoluble or in a solvent such as water which is removed in vacuo; by freeze drying; or by exchanging the anions of an existing salt for another anion on a suitable ion exchange resin.", "The present invention includes within its scope solvates of the disclosed compounds and salts, such as hydrates of the compounds and their salts, for example, a hydrated formate salt or a hydrated xinafoate salt.", "In particular examples, the compounds include those shown below in Table 1.TABLE 1 Compound Number Structure Name A1 N2-(3,4,5-trimethyl)phenyl-5-methyl- N4-(2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl)-2,4- pyrimidinediamine A2 4-[5-methyl-4-(2-oxo-2,3-dihydro- benzoxazol-5-ylamino)-pyrimidin-2- ylamino]-N-phenyl-benzamide A3 N4-(benzo[d]oxazol-2(3H)-on-5-yl)- N2-(4-aminocarbonylphenyl)-5- methylpyrimidine-2,4-diamine A4 N2-(3,4-dimethyl-5- hydroxymethyl)phenyl-5-methyl-N4- (2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)-2,4-pyrimidinediamine A5 N-cyclobutyl-4-[5-methyl-4-(2-oxo- 2,3-dihydro-benzooxazol-5-ylamino)- pyrimidin-2-ylamino]-benzamide A6 N4-(benzo[d]oxazol-2(3H)-on-5-yl)- N2-(3-methylsulfonyl)phenyl)-5- methylpyrimidine-2,4-diamine A7 5-(2-(3-(fluoromethyl)-5- methylphenylamino)-5- methylpyrimidin-4- ylamino)benzo[d]oxazol-2(3H)-one A8 N2-(3-fluoro-4-methyl)phenyl-5- methyl-N4-(2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl)-2,4- pyrimidinediamine A9 N2-(3,5-dimethyl-4- hydroxymethyl)phenyl-5-methyl-N4- (2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl)-2,4-pyrimidinediamine A10 5-[2-(3,4-dimethyl-phenylamino)-5- methyl-pyrimidin-4-ylamino]-3H- benzooxazol-2-one A11 5-(2-(3-chloro-4,5- dimethoxyphenylamino)-5- methylpyrimidin-4- ylamino)benzo[d]oxazol-2(3H)-one A12 5-(2-(benzo[d]isoxazol-6-ylamino)-5- methylpyrimidin-4- ylamino)benzo[d]oxazol-2(3H)-one A13 N2-(3-methoxy-5- trifluoromethyl)phenyl-5-methyl-N4- (2-oxo-2,3-dihydro-1,3-benzoxazol- 5-yl)-2,4-pyrimidinediamine A14 N2-(3,5-dimethyl-4-fluoro)phenyl-5- methyl-N4-(2-oxo-2,3-dihydro-1,3- benzoxazol-5-yl)-2,4- pyrimidinediamine A15 N2-(3-methoxy-5- trifluoromethyl)phenyl-5-methyl-N4- [3-(phosphonooxy)methyl-2-oxo-2,3- dihydro-1,3-benzoxazol-5-yl]-2,4- pyrimidinediamine bis-sodium salt A16 Sodium (5-(2-(4-fluoro-3-methoxy-5- methylphenylamino)-5- methylpyrimidin-4-ylamino)-2- oxobenzo[d]oxazol-3(2H)-yl)methyl phosphate A17 5-methyl-N4-[3- (phosphonooxy)methyl-2-oxo-2,3- dihydro-1,3-benzoxazol-5-yl]-N2- (3,4,5-trimethyl)phenyl-2,4- pyrimidinediamine bis-sodium salt A18 N2-(3,5-dimethyl-4-fluoro)phenyl-5- methyl-N4-[3-(phosphonooxy)methyl- 2-oxo-2,3-dihydro-1,3-benzoxazol-5- yl]-2,4-pyrimidinediamine bis-sodium salt I-432 5-(2-(4-fluoro-3-methoxy-5- methylphenylamino)-5- methylpyrimidin-4- ylamino)benzo[d]oxazol-2(3H)-one The compounds and methods of their synthesis are described in PCT Patent Publication Nos.", "WO 2010/085684 and WO 2012/015972, both of which are incorporated by reference in their entirety herein, and specifically incorporating compound I-432, 5-(2-(4-fluoro-3-methoxy-5-methylphenylamino)-5-methylpyrimidin-4-ylamino)benzo[d]oxazol-2(3H)-one, as disclosed by WO 2010/085684.B.", "Prodrugs Those of skill in the art will appreciate that the compounds described herein can include functional groups that can be masked with progroups to create prodrugs.", "Such prodrugs are usually, but need not be, pharmacologically inactive until converted into their active drug form.", "Indeed, at least some of the compounds described herein include promoieties that are hydrolyzable or otherwise cleavable under conditions of use.", "For example, ester groups commonly undergo acid-catalyzed hydrolysis to yield the parent carboxylic acid when exposed to the acidic conditions of the stomach or base-catalyzed hydrolysis when exposed to the basic conditions of the intestine or blood.", "Thus, when administered to a subject orally, compounds that include ester moieties can be considered prodrugs of their corresponding carboxylic acid, regardless of whether the ester form is pharmacologically active.", "The mechanism by which the progroups metabolize is not critical and can be caused, for example, by hydrolysis under the acidic conditions of the stomach, as described above, and/or by enzymes present in the digestive tract and/or tissues or organs of the body.", "Indeed, the progroup(s) can be selected to metabolize at a particular site within the body.", "For example, many esters are cleaved under the acidic conditions found in the stomach.", "Prodrugs designed to cleave chemically in the stomach to the active compounds can employ progroups including such esters.", "Alternatively, the progroups can be designed to metabolize in the presence of enzymes such as esterases, amidases, lipolases, and phosphatases, including ATPases and kinase, etc.", "Progroups including linkages capable of metabolizing in vivo are well known and include, by way of example and not limitation, ethers, thioethers, silylethers, silylthioethers, esters, thioesters, carbonates, thiocarbonates, carbamates, thiocarbamates, ureas, thioureas, and carboxamides.", "In some instances, a “precursor” group that is oxidized by oxidative enzymes such as, for example, cytochrome P450 of the liver, to a metabolizable group, can be selected.", "In the prodrugs, any available functional moiety can be masked with a progroup to yield a prodrug.", "Functional groups within the disclosed compounds that can be masked with progroups for inclusion in a promoiety include, but are not limited to, amines (primary and secondary), hydroxyls, sulfanyls (thiols), and carboxyls.", "A wide variety of progroups, as well as the resultant promoieties, suitable for masking functional groups in active compounds to yield prodrugs are well-known in the art.", "For example, a hydroxyl functional group can be masked as a sulfonate, ester, or carbonate promoiety, which can be hydrolyzed in vivo to provide the hydroxyl group.", "An amino functional group can be masked as an amide, carbamate, imine, urea, phosphenyl, phosphoryl, or sulfenyl promoiety, which can be hydrolyzed in vivo to provide the amino group.", "A carboxyl group can be masked as an ester (including silyl esters and thioesters), amide, or hydrazide promoiety, which can be hydrolyzed in vivo to provide the carboxyl group.", "In some embodiments, the progroup is a phosphate-containing progroup of the formula —(CRdRd)y—O—P(O)(OH)(OH), or a salt thereof, y is an integer ranging from 1 to 3, typically 1 or 2; and each Rd is, independently of the others, selected from hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted methyl and substituted or unsubstituted benzyl.", "In a specific embodiment, each Rd is, independently of the others, selected from hydrogen and unsubstituted lower alkyl.", "Specific exemplary phosphate-containing progroups include —CH2—O—P(O)(OH)(OH) and —CH2CH2—O—P(O)(OH)(OH) and/or the corresponding salts.", "Other specific examples of suitable progroups and their respective promoieties will be apparent to those of skill in the art.", "All of these progroups, alone or in combinations, can be included in the prodrugs.", "In some embodiments of the disclosed compounds and methods of using the compounds, the progroup(s) can be attached to any available primary or secondary amine, including, for example, the N2 nitrogen atom of the 2,4-pyrimidinediamine, the N4 nitrogen atom of the 2,4-pyrimidinediamine, and/or a primary or secondary nitrogen atom included in a substituent on the 2,4-pyrimidinediamine.", "As noted above, the identity of the progroup is not critical, provided that it can be metabolized under the desired conditions of use, for example, under the acidic conditions found in the stomach and/or by enzymes found in vivo, to yield a biologically active group, for example, the compounds as described herein.", "Thus, skilled artisans will appreciate that the progroup can include virtually any known or later-discovered hydroxyl, amine or thiol protecting group.", "Non-limiting examples of suitable protecting groups can be found, for example, in Protective Groups in Organic Synthesis, Greene & Wuts, 2nd Ed., John Wiley & Sons, New York, 1991 (especially pages 10-142 (alcohols), 277-308 (thiols) and 309-405 (amines)), the disclosure of which is incorporated herein by reference.", "Compounds A1-A18 inhibit the JAK/Stat pathway.", "The activity of a specified compound may be assessed in vitro or in vivo.", "In some embodiments, the activity of a specified compound can be tested in a cellular assay.", "Suitable assays include assays that determine inhibition of either the phosphorylation activity or ATPase activity of a JAK kinase.", "Thus, a compound is said to inhibit an activity of a JAK kinase if it inhibits the phosphorylation or ATPase activity of a JAK kinase with an IC50 of about 20 μM or less.", "One means of assaying for such inhibition is detection of the effect of the 2,4-substituted pyrimidinediamine compounds on the upregulation of downstream gene products.", "For example, the activity of the disclosed compounds may be characterized by assaying the effect of the 2,4-substituted pyrimidinediamine compounds described herein on the proliferative response of primary human T-cells.", "In this assay, primary human T-cells derived from peripheral blood and pre-activated through stimulation of the T-cell receptor and CD28, proliferate in culture in response to the cytokine Interleukin-2 (IL-2).", "This proliferative response is dependent on the activation of JAK1 and JAK3 tyrosine kinases, which phosphorylate and activate the transcription factor Stat-5.The primary human T-cells are incubated with the 2,4-substituted pyrimidinediamine compounds in the presence of IL-2 for 72 hours and at the assay endpoint intracellular ATP concentrations are measured to assess cell viability.", "A reduction in cell proliferation compared to control conditions is indicative of inhibition of the JAK kinase pathway.", "Active compounds as described herein generally inhibit the JAK kinase pathway with an IC50 in the range of about 1 mM or less, as measured in the assays described herein.", "Of course, skilled artisans will appreciate that compounds which exhibit lower IC50s, for example on the order of 100 μM, 75 μM, 50 μM, 40 μM, 30 μM, 20 μM, 15 μM, 10 μM, 5 μM, 1 μM, 500 nM, 100 nM, 10 nM, 1 nM, or even lower, may be particularly useful in therapeutic applications.", "In instances where activity specific to a particular cell type is desired, the compound may be assayed for activity with the desired cell type and counter-screened for a lack of activity against other cell types.", "The desired degree of “inactivity” in such counter screens, or the desired ratio of activity vs. inactivity may vary for different situations, and may be selected by the user.", "C. Pharmaceutical Compositions In some embodiments a pharmaceutical composition including a compound as described in any of the embodiments herein is administered to a subject.", "Pharmaceutical compositions described herein can be manufactured by means of conventional mixing, dissolving, granulating, dragee-making, levigating, emulsifying, encapsulating, entrapping, or lyophilization processes.", "The compositions can be formulated in conventional manner using one or more physiologically acceptable carriers, diluents, excipients, or auxiliaries which facilitate processing of the active compounds into preparations which can be used pharmaceutically.", "Remington: The Science and Practice of Pharmacy, The University of the Sciences in Philadelphia, Editor, Lippincott, Williams, & Wilkins, Philadelphia, Pa., 21st Edition (2005).", "The disclosed compounds can be formulated in the pharmaceutical compositions per se, or in the form of a hydrate, solvate, N-oxide, or pharmaceutically acceptable salt, as described herein.", "Typically, such salts are more soluble in aqueous solutions than the corresponding free acids and bases, but salts having lower solubility than the corresponding free acids and bases can also be formed.", "One embodiment is a pharmaceutical formulation including at least one of compounds A1-A18, or a prodrug thereof, and at least one pharmaceutically acceptable excipient, diluent, preservative, stabilizer, or mixture thereof.", "The compounds can be provided in a variety of formulations and dosages.", "The compounds can be provided in a pharmaceutically acceptable form, including where the compound can be formulated in the pharmaceutical compositions per se, or in the form of a hydrate, solvate, N-oxide, or pharmaceutically acceptable salt, as described herein.", "Typically, such salts are more soluble in aqueous solutions than the corresponding free acids and bases, but salts having lower solubility than the corresponding free acids and bases can also be formed.", "It is to be understood that reference to the compound or “active” in discussions of formulations is also intended to include, where appropriate as known to those of skill in the art, formulation of the prodrugs of the disclosed compounds.", "In some embodiments, the compounds are provided as non-toxic, pharmaceutically acceptable salts.", "Generally, pharmaceutically acceptable salts are those salts that retain substantially one or more of the desired pharmacological activities of the parent compound and which are suitable for administration to humans.", "Suitable pharmaceutically acceptable salts of the compounds described herein include acid addition salts such as those formed with hydrochloric acid, fumaric acid, p-toluenesulfonic acid, maleic acid, succinic acid, acetic acid, citric acid, tartaric acid, carbonic acid, or phosphoric acid.", "Salts of amine groups can also include quaternary ammonium salts in which the amino nitrogen atom carries a suitable organic group such as an alkyl, alkenyl, alkynyl, or substituted alkyl moiety.", "Furthermore, where presently disclosed compounds carry an acidic moiety, suitable pharmaceutically acceptable salts thereof can include metal salts such as alkali metal salts, for example, sodium or potassium salts; and alkaline earth metal salts, for example, calcium or magnesium salts.", "The pharmaceutical compositions for the administration of the disclosed compounds can be conveniently presented in dosage unit form and can be prepared by any of the methods well known in the art of pharmacy.", "The pharmaceutical compositions can be, for example, prepared by uniformly and intimately bringing the active ingredient into association with a liquid carrier, a finely divided solid carrier or both, and then, if necessary, shaping the product into the desired formulation.", "In the pharmaceutical composition the active object compound is included in an amount sufficient to produce the desired therapeutic effect.", "In particular disclosed embodiments, the composition comprises from about 0.0001 to about 100 mg/kg/day, from about 0.001 to about 100 mg/kg/day; or from about 0.01 mg/kg/day to about 100 mg/kg/day of the compound.", "The composition may also further comprise a pharmaceutically acceptable carrier, selected from lactose, glucose, raffinose, melezitose, lactitol, maltitol, trehalose, sucrose, mannitol, starch, or combinations thereof.", "In particular disclosed embodiments, the composition comprises about 1 to about 20 total weight percent of the compound and the one or more other therapeutic agents, and about 99 to about 80 weight percent of the pharmaceutically acceptable carrier.", "In certain disclosed embodiments, the compound is a dry powder, which may be encapsulated.", "Typically, the compound has a particle size, which ranges from about 0.4 μm to about 5 μm.", "The compounds can be administered by oral, parenteral (for example, intramuscular, intraperitoneal, intravenous, ICV, intracisternal injection or infusion, subcutaneous injection, or implant), inhalation, spray, nasal, vaginal, rectal (for example, rectal suppository or enema), sublingual, urethral (for example, urethral suppository) or topical routes of administration (for example, gel, ointment, cream, aerosol, etc.)", "and can be formulated, alone or together, in suitable dosage unit formulations containing conventional non-toxic pharmaceutically acceptable carriers, adjuvants, excipients, and vehicles appropriate for each route of administration.", "In addition to the treatment of warm-blooded animals such as mice, rats, horses, cattle, sheep, dogs, cats, and monkeys, the compounds described herein can be used for treating humans.", "Administration of the disclosed compounds, or their pharmaceutically acceptable salts, in pure form or in an appropriate pharmaceutical composition, can be carried out via any of the accepted modes of administration or agents for serving similar utilities.", "Thus, administration can be, for example, orally, nasally, parenterally (e.g., intravenous, intramuscular, or subcutaneous), topically, transdermally, intravaginally, intravesically, intracisternally, or rectally, in the form of solid, semi-solid, lyophilized powder, or liquid dosage forms, such as for example, tablets, suppositories, pills, soft elastic and hard gelatin capsules, powders, solutions, suspensions, or aerosols, or the like, preferably in unit dosage forms suitable for simple administration of precise dosages.", "Systemic formulations include those designed for administration by injection (for example, subcutaneous, intravenous, intramuscular, intrathecal, or intraperitoneal injection) as well as those designed for transdermal, transmucosal, oral, or pulmonary administration.", "Useful injectable preparations include sterile suspensions, solutions, or emulsions of the active compound(s) in aqueous or oily vehicles.", "The compositions can also contain formulating agents, such as suspending, stabilizing, and/or dispersing agents.", "The formulations for injection can be presented in unit dosage form, for example, in ampules or in multidose containers, and can contain added preservatives.", "Alternatively, the injectable formulation can be provided in powder form for reconstitution with a suitable vehicle, including but not limited to sterile pyrogen-free water, buffer, and dextrose solution, before use.", "To this end, the active compound(s) can be dried by any art-known technique, such as lyophilization, and reconstituted prior to use.", "For oral administration, the pharmaceutical compositions can take the form of, for example, lozenges, tablets, or capsules prepared by conventional means with pharmaceutically acceptable excipients such as binding agents (for example, pregelatinised maize starch, polyvinylpyrrolidone, or hydroxypropyl methylcellulose); fillers (for example, lactose, microcrystalline cellulose, or calcium hydrogen phosphate); lubricants (for example, magnesium stearate, talc, or silica); disintegrants (for example, potato starch or sodium starch glycolate); or wetting agents (for example, sodium lauryl sulfate).", "The tablets can be coated by methods well known in the art with, for example, sugars, films, or enteric coatings.", "Additionally, the pharmaceutical compositions containing at least one of compounds A1-A18 as active ingredient or prodrug thereof in a form suitable for oral use can also include, for example, troches, lozenges, aqueous or oily suspensions, dispersible powders or granules, emulsions, hard or soft capsules, or syrups or elixirs.", "Compositions intended for oral use can be prepared according to any method known to the art for the manufacture of pharmaceutical compositions, and such compositions can contain one or more agents including sweetening agents, flavoring agents, coloring agents, and preserving agents in order to provide pharmaceutically elegant and palatable preparations.", "Tablets contain the active ingredient (including drug and/or prodrug) in admixture with non-toxic pharmaceutically acceptable excipients which are suitable for the manufacture of tablets.", "These excipients can be for example, inert diluents, such as calcium carbonate, sodium carbonate, lactose, calcium phosphate or sodium phosphate; granulating and disintegrating agents (for example, corn starch or alginic acid); binding agents (for example starch, gelatin, or acacia); and lubricating agents (for example, magnesium stearate, stearic acid, or talc).", "The tablets can be left uncoated or they can be coated by known techniques to delay disintegration and absorption in the gastrointestinal tract and thereby provide a sustained action over a longer period.", "For example, a time delay material such as glyceryl monostearate or glyceryl distearate can be employed.", "They can also be coated by the techniques described in the U.S. Pat.", "Nos.", "4,256,108; 4,166,452; and U.S. Pat.", "No.", "4,265,874 to form osmotic therapeutic tablets for control release.", "The pharmaceutical compositions described herein can also be in the form of oil-in-water emulsions.", "Liquid preparations for oral administration can take the form of, for example, elixirs, solutions, syrups, or suspensions, or they can be presented as a dry product for constitution with water or other suitable vehicle before use.", "Such liquid preparations can be prepared by conventional means with pharmaceutically acceptable additives such as suspending agents (for example, sorbitol syrup, cellulose derivatives, or hydrogenated edible fats); emulsifying agents (for example, lecithin, or acacia); non-aqueous vehicles (for example, almond oil, oily esters, ethyl alcohol, Cremaphor® emulsifying agent, or fractionated vegetable oils); and preservatives (for example, methyl or propyl-p-hydroxybenzoates or sorbic acid).", "The preparations can also contain buffer salts, preservatives, flavoring, coloring, and sweetening agents as appropriate.", "Preparations for oral administration can be suitably formulated to give controlled release of the active compound, as is well known.", "For buccal administration, the compositions can take the form of tablets or lozenges formulated in the conventional manner.", "The pharmaceutical compositions can be in the form of a sterile injectable aqueous or oleaginous suspension.", "This suspension can be formulated according to the known art using those suitable dispersing or wetting agents and suspending agents which have been mentioned above.", "The sterile injectable preparation can also be a sterile injectable solution or suspension in a non-toxic parenterally-acceptable diluent or solvent.", "Among the acceptable vehicles and solvents that can be employed are water, Ringer's solution, and isotonic sodium chloride solution.", "For rectal routes of administration, the active compound(s) can be formulated as solutions (for retention enemas), suppositories, or ointments containing conventional suppository bases such as cocoa butter or other glycerides.", "For transmucosal administration, penetrants appropriate to the barrier to be permeated are used in the formulation.", "Such penetrants are known in the art.", "For topical administration, the disclosed compound(s) or prodrug(s) can be formulated as solutions, gels, ointments, creams, suspensions, etc., as are well-known in the art.", "Such formulations can be included in a patch or other transdermal delivery system or formulation, for example, a formulation with ingredients specifically designed to aid transport of the compound through the skin and into the body tissues.", "For nasal administration or administration by inhalation or insufflation, the active compound(s) or prodrug(s) can be conveniently delivered in the form of a dry powder (either alone, as a mixture, for example in a dry blend with lactose, or as a mixed component particle, for example, mixed with phospholipids, such as phosphatidylcholine) from a dry powder inhaler or as an aerosol spray from pressurized packs or a nebulizer with the use of a suitable propellant (for example, dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, fluorocarbons, carbon dioxide, or other suitable gas).", "In the case of a pressurized aerosol, the dosage unit can be determined by providing a valve to deliver a metered amount.", "Capsules and cartridges for use in an inhaler or insufflator (for example, capsules and cartridges including gelatin) can be formulated containing a powder mix of the compound and a suitable powder base such as lactose or starch.", "Prior to use in a dry powder or suspension formulation, the drug product typically is micronized to a size suitable for delivery by inhalation (typically less than about 5 microns).", "This may be achieved as is known to those of skill in the art by an appropriate method, such as spiral jet milling, fluid bed jet milling, supercritical fluid processing, spray drying and the like.", "For prolonged delivery, the compound(s) or prodrug(s) can be formulated as a depot preparation for administration by implantation or intramuscular injection.", "The active ingredient can be formulated with suitable polymeric or hydrophobic materials (for example, as an emulsion in an acceptable oil) or ion exchange resins, or as sparingly soluble derivatives (for example, as a sparingly soluble salt).", "Alternatively, transdermal delivery systems manufactured as an adhesive disc or patch which slowly releases the active compound(s) for percutaneous absorption can be used.", "To this end, permeation enhancers can be used to facilitate transdermal penetration of the active compound(s).", "Suitable transdermal patches are described in, for example, U.S. Pat.", "No.", "5,407,713; U.S. Pat.", "No.", "5,352,456; U.S. Pat.", "No.", "5,332,213; U.S. Pat.", "No.", "5,336,168; U.S. Pat.", "No.", "5,290,561; U.S. Pat.", "No.", "5,254,346; U.S. Pat.", "No.", "5,164,189; U.S. Pat.", "No.", "5,163,899; U.S. Pat.", "No.", "5,088,977; U.S. Pat.", "No.", "5,087,240; U.S. Pat.", "No.", "5,008,110; and U.S. Pat.", "No.", "4,921,475.Alternatively, other pharmaceutical delivery systems can be employed.", "Liposomes and emulsions are well-known examples of delivery vehicles that can be used to deliver active compound(s) or prodrug(s).", "Certain organic solvents such as dimethylsulfoxide (DMSO) can also be employed, although usually at the cost of greater toxicity.", "D. Second Therapeutic Agents Disclosed embodiments of the compound may be administered singly, as compositions comprising one or more of compounds A1-A18, or as compositions comprising the compound and a second therapeutic agent.", "In particular disclosed embodiments, the second therapeutic agent may be selected from any of the following: analgesics—morphine, fentanyl, hydromorphone, oxycodone, codeine, acetaminophen, hydrocodone, buprenorphine, tramadol, venlafaxine, flupirtine, meperidine, pentazocine, dextromoramide, dipipanone; antibiotics—aminoglycosides (e.g., amikacin, gentamicin, kanamycin, neomycin, netilmicin, tobramycin, and paromycin), carbapenems (e.g., ertapenem, doripenem, imipenem, cilastatin, and meropenem), cephalosporins (e.g., cefadroxil, cefazolin, cefalotin, cephalexin, cefaclor, cefamandole, cefoxitin, cefprozil, cefuroxime, cefixime, cefdinir, cefditoren, cefoperazone, cefotaxime, cefpodoxime, ceftazidime, ceftibuten, ceftizoxime, ceftriaxone, cefepime, and cefobiprole), glycopeptides (e.g., teicoplanin, vancomycin, and telavancin), lincosamides (e.g., clindamycin and incomysin), lipopeptides) e.g., daptomycin), macrolides (azithromycin, clarithromycin, dirithromycin, erythromycin, roxithromycin, troleandomycin, telithromycin, and spectinomycin), monobactams (e.g., aztreonam), nitrofurans (e.g., furazolidone and nitrofurantoin), penicilllins (e.g., amoxicillin, ampicillin, azlocillin, carbenicillin, cloxacillin, dicloxacillin, flucloxacillin, mezlocillin, methicillin, nafcillin, oxacillin, penicillin G, penicillin V, piperacillin, temocillin, and ticarcillin), penicillin combinations (e.g., amoxicillin/clavulanate, ampicillin/sulbactam, piperacillin/tazobactam, and ticarcillin/clavulanate), polypeptides (e.g., bacitracin, colistin, and polymyxin B), quinolones (e.g., ciprofloxacin, enoxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, nalidixic acid, norfloxacin, ofloxacin, trovafloxacin, grepafloxacin, sparfloxacin, and temafloxacin), sulfonamides (e.g., mafenide, sulfonamidochrysoidine, sulfacetamide, sulfadiazine, silver sulfadiazine, sulfamethizole, sulfamethoxazole, sulfanilimide, sulfasalazine, sulfisoxazole, trimethoprim, and trimethoprim-sulfamethoxaxzole), tetracyclines (e.g., demeclocycline, doxycycline, minocycline, oxytetracycline, and tetracycline), antimycobacterial compounds (e.g., clofazimine, dapsone, capreomycin, cycloserine, ethambutol, ethionamide, isoniazid, pyrazinamide, rifampicin (rifampin), rifabutin, rifapentine, and streptomycin), and others.", "such as arsphenamine, chloramphenicol, fosfomycin, fusidic acid, linezolid, metronidazole, mupirocin, platensimycin, quinuprisin/dalfopristin, rifaximin, thiamphenicol, tigecycline, and tinidazole; antibodies—anti-TNF-α antibody, e.g., infliximab (Remicade®); anticoagulants—warfarin (Coumadin®), acenocoumarol, phenprocoumon, atromentin, phenindione, heparin, fondaparinux, idraparinux, rivaroxaban, apixaban, hirudin, lepirudin, bivalirudin, argatrobam, dabigatran, ximelagatran, batroxobin, hementin; anti-inflammatory agents—steroids, e.g., budesonide, nonsteroidal anti-inflammatory agents, e.g., aminosalicylates (e.g., sulfasalazine, mesalamine, olsalazine, and balsalazide), cyclooxygenase inhibitors (COX-2 inhibitors, such as rofecoxib, celecoxib), diclofenac, etodolac, famotidine, fenoprofen, flurbiprofen, ketoprofen, ketorolac, ibuprofen, indomethacin, meclofenamate, mefenamic acid, meloxicam, nambumetone, naproxen, oxaprozin, piroxicam, salsalate, sulindac, tolmetin; immunosuppressants—mercaptopurine, corticosteroids such as dexamethasone, hydrocortisone, prednisone, methylprednisolone and prednisolone, alkylating agents such as cyclophosphamide, calcineurin inhibitors such as cyclosporine, sirolimus and tacrolimus, inhibitors of inosine monophosphate dehydrogenase (IMPDH) such as mycophenolate, mycophenolate mofetil and azathioprine, and agents designed to suppress cellular immunity while leaving the recipient's humoral immunologic response intact, including various antibodies (for example, antilymphocyte globulin (ALG), antithymocyte globulin (ATG), monoclonal anti-T-cell antibodies (OKT3)) and irradiation.", "Azathioprine is currently available from Salix Pharmaceuticals, Inc. under the brand name Azasan®; mercaptopurine is currently available from Gate Pharmaceuticals, Inc. under the brand name Purinethol®; prednisone and prednisolone are currently available from Roxane Laboratories, Inc.; Methyl prednisolone is currently available from Pfizer; sirolimus (rapamycin) is currently available from Wyeth-Ayerst under the brand name Rapamune®; tacrolimus is currently available from Fujisawa under the brand name Prograf®; cyclosporine is current available from Novartis under the brand dame Sandimmune® and Abbott under the brand name Gengraf®; IMPDH inhibitors such as mycophenolate mofetil and mycophenolic acid are currently available from Roche under the brand name Cellcept® and Novartis under the brand name Myfortic®; azathioprine is currently available from Glaxo Smith Kline under the brand name Imuran®; and antibodies are currently available from Ortho Biotech under the brand name Orthoclone®, Novartis under the brand name Simulect® (basiliximab) and Roche under the brand name Zenapax® (daclizumab).", "Guanylate cyclase-C receptor agonists or intestinal secretagogues—for example linaclotide, sold under the name Linzess®.", "These various agents can be used in accordance with their standard or common dosages, as specified in the prescribing information accompanying commercially available forms of the drugs (see also, the prescribing information in the 2006 Edition of The Physician's Desk Reference), the disclosures of which are incorporated herein by reference.", "IV.", "Method of Use The disclosed compounds, or compositions thereof, can be used to treat and/or prevent certain autoimmune disorders, such as inflammatory bowel disorders.", "Compounds A1-A18, prodrug(s) thereof, or compositions thereof, will generally be used in an amount effective to achieve the intended result, for example, in an amount effective to treat or prevent the particular condition being treated.", "The compound(s) can be administered therapeutically to achieve therapeutic benefit or prophylactically to achieve prophylactic benefit.", "By therapeutic benefit is meant eradication or amelioration of the underlying disorder being treated and/or eradication or amelioration of one or more of the symptoms associated with the underlying disorder such that the subject reports an improvement in feeling or condition, notwithstanding that the subject may still be afflicted with the underlying disorder.", "By prophylactic benefit is meant prevention or delayed onset of a disorder.", "For prophylactic administration, the compound can be administered to a subject at risk of developing one of the previously described conditions.", "For example, if it is suspected but unknown whether a subject is susceptible to an inflammatory bowel disease, the compound can be administered prior to the onset of symptoms resulting from the condition.", "Alternatively, prophylactic administration can be applied to avoid the onset of symptoms in a subject diagnosed with the underlying disorder.", "For example, a compound can be administered to a genetically predisposed subject prior to expected onset of the disease, such as in the case of an inflammatory bowel disease, e.g., ulcerative colitis or Crohn's disease.", "The amount of compound administered will depend upon a variety of factors, including, for example, the particular condition being treated, the mode of administration, whether the desired benefit is prophylactic or therapeutic, the severity of the condition being treated, the age and weight of the subject, the general health of the subject, and/or the bioavailability of the particular active compound.", "Determination of an effective dosage is well within the capabilities of those skilled in the art.", "Dosage, and frequency of administration of the compounds or prodrugs thereof, will also depend on whether the compounds are formulated for treatment of acute episodes of a condition or for the prophylactic treatment of a disorder.", "A skilled practitioner will be able to determine the optimal dose for a particular individual.", "Determination of an effective dosage is well within the capabilities of those skilled in the art.", "Effective dosages can be estimated initially from in vitro assays.", "For example, an initial dosage for use in animals can be formulated to achieve a circulating blood or serum concentration of active compound that is at or above an IC50 of the particular compound as measured in an in vitro assay.", "Calculating dosages to achieve such circulating blood or serum concentrations taking into account the bioavailability of the particular compound is well within the capabilities of skilled artisans.", "For guidance, the reader is referred to Fingl & Woodbury, “General Principles,” In: Goodman and Gilman's The Pharmaceutical Basis of Therapeutics, Chapter 1, 12th edition, Pergamon Press, and the references cited therein.", "Initial dosages can also be estimated from in vivo data, such as animal models.", "Animal models useful for testing the efficacy of compounds to treat or prevent the various diseases described above are well-known in the art.", "Suitable animal models of hypersensitivity or allergic reactions are described in Foster, (1995) Allergy 50(21Suppl):6-9, discussion 34-38 and Tumas et al., (2001), J.", "Allergy Clin.", "Immunol.", "107(6):1025-1033.Suitable animal models of allergic rhinitis are described in Szelenyi et al., (2000), Arzneimittelforschung 50(11):1037-42; Kawaguchi et al., (1994), Clin.", "Exp.", "Allergy 24(3):238-244 and Sugimoto et al., (2000), Immunopharmacology 48(1):1-7.Suitable animal models of allergic conjunctivitis are described in Carreras et al., (1993), Br.", "J. Ophthalmol.", "77(8):509-514; Saiga et al., (1992), Ophthalmic Res.", "24(1):45-50; and Kunert et al., (2001), Invest.", "Ophthalmol.", "Vis.", "Sci.", "42(11):2483-2489.Suitable animal models of systemic mastocytosis are described in O'Keefe et al., (1987), J. Vet.", "Intern.", "Med.", "1(2):75-80 and Bean-Knudsen et al., (1989), Vet.", "Pathol.", "26(1):90-92.Suitable animal models of hyper IgE syndrome are described in Claman et al., (1990), Clin.", "Immunol.", "Immunopathol.", "56(1):46-53.Suitable animal models of B-cell lymphoma are described in Hough et al., (1998), Proc.", "Natl.", "Acad.", "Sci.", "USA 95:13853-13858 and Hakim et al., (1996), J. Immunol.", "157(12):5503-5511.Suitable animal models of atopic disorders such as atopic dermatitis, atopic eczema, and atopic asthma are described in Chan et al., (2001), J.", "Invest.", "Dermatol.", "117(4):977-983 and Suto et al., (1999), Int.", "Arch.", "Allergy Immunol.", "120(Suppl 1):70-75.Suitable animal models of transplant rejection, such as models of HVGR, are described in O'Shea et al., (2004), Nature Reviews Drug Discovery 3:555-564; Cetkovic-Curlje & Tibbles, (2004), Current Pharmaceutical Design 10:1767-1784; and Chengelian et al., (2003), Science 302:875-878.Ordinarily skilled artisans can routinely adapt such information to determine dosages suitable for human administration.", "Dosage amounts will typically be in the range of from about 0.0001 or 0.001 or 0.01 mg/kg/day to about 100 mg/kg/day, but can be higher or lower, depending upon, among other factors, the activity of the compound, its bioavailability, the mode of administration, and various factors discussed above.", "More typically, the dosage (or effective amount) may range from about 5 mg/kg to about 20 mg/kg; even more typically from about 10 mg/kg to about 20 mg/kg; even more typically from about 15 mg/kg to about 20 mg/kg.", "Dosage amount and interval can be adjusted individually to provide plasma levels of the compound(s) which are sufficient to maintain therapeutic or prophylactic effect.", "For example, the compounds can be administered once per week, several times per week (e.g., every other day), once per day, or multiple times per day, depending upon, among other things, the mode of administration, the specific indication being treated, and the judgment of the prescribing physician.", "In cases of local administration or selective uptake, such as local topical administration, the effective local concentration of active compound(s) may not be related to plasma concentration.", "Skilled artisans will be able to optimize effective local dosages without undue experimentation.", "In one embodiment the daily dosage may be greater than zero milligrams per day, such as from about 1 mg/day, up to at least about 2 grams/day.", "For certain embodiments, the dosage is about 2 mg/day, about 3 mg/day, about 5 mg/day, about 10 mg/day, about 15 mg/day, about 20 mg/day or about 50 mg/day.", "Preferably, the compound(s) will provide therapeutic or prophylactic benefit without causing substantial toxicity.", "Toxicity of the compound(s) can be determined using standard pharmaceutical procedures.", "The dose ratio between toxic and therapeutic (or prophylactic) effect is the therapeutic index.", "Compounds(s) that exhibit high therapeutic indices are preferred.", "The foregoing disclosure pertaining to the dosage requirements for the compounds is pertinent to dosages required for prodrugs, with the realization, apparent to the skilled artisan, that the amount of prodrug(s) administered will also depend upon a variety of factors, including, for example, the bioavailability of the particular prodrug(s) and the conversation rate and efficiency into active drug compound under the selected route of administration.", "Determination of an effective dosage of prodrug(s) for a particular use and mode of administration is well within the capabilities of those skilled in the art.", "Effective dosages can be estimated initially from in vitro activity and metabolism assays.", "For example, an initial dosage of prodrug for use in animals can be formulated to achieve a circulating blood or serum concentration of the metabolite active compound that is at or above an IC50 of the particular compound as measured in an in vitro assay, such as the in vitro CHMC or BMMC and other in vitro assays described in U.S. application Ser.", "No.", "10/355,543 filed Jan. 31, 2003 (US2004/0029902A1), international application Serial No.", "PCT/US03/03022 filed Jan. 31, 2003 (WO 03/063794), U.S. application Ser.", "No.", "10/631,029 filed Jul.", "29, 2003, international application Serial No.", "PCT/US03/24087 (WO2004/014382), U.S. application Ser.", "No.", "10/903,263 filed Jul.", "30, 2004, and international application Serial No.", "PCT/US2004/24716 (WO2005/016893).", "Calculating dosages to achieve such circulating blood or serum concentrations, taking into account the bioavailability of the particular prodrug via the desired route of administration, is well within the capabilities of skilled artisans.", "For guidance, the reader is referred to Fingl & Woodbury, “General Principles,” In: Goodman and Gilman's The Pharmaceutical Basis of Therapeutics, Chapter 1, 12th edition, Pergamon Press, and the references cited therein.", "Particular disclosed embodiments concern a method, comprising administering to a subject one or more of the disclosed compounds in an amount effective to inhibit or prevent a disease, such as an inflammatory bowel disease.", "For example, the compound(s) may be administered to a subject identified as having an inflammatory bowel disease or being at risk of developing an inflammatory bowel disease.", "In particular disclosed embodiments, administering comprises exposing the subject to a dosage of the compound that is adjusted to inhibit or prevent the disease.", "The compound also may be administered alone or as a pharmaceutical composition and typically is administered parenterally (e.g., intravenously, infusion, or implant), orally, or rectally.", "Additionally, the compound may be administered prophylactically.", "The method may further comprise monitoring blood levels of the compound, or a metabolite thereof, in the subject to ascertain the effect of the compound.", "The method also may further comprise monitoring one or more biomarkers associated with a disease, such as an inflammatory bowel disease.", "Thus, in certain embodiments, the method further comprises monitoring one or more biomarkers associated with an inflammatory bowel disease.", "Suitable biomarkers may include serologic markers such as C-reactive protein, perinuclear antineutrophil cytoplasmic antibody, anti-Saccharomyces cerevisiae antibody, anti-OmpC (outer membrane porin C), anti-I2 protein antibody, anti-glycan antibodies, anti-chitobioside IgA, anti-laminaribioside IgG, anti-manobioside IgG, toll-like receptors 2 and 4, β-defensin-1, ubiquitination factor E4A (UBE4A), CXCL16 (a chemokine), resistin, apolipoprotein A-IV; genetic biomarkers such as NOD2/CARD 15, NOD1/CARD4; fecal biomarkers such as fecal calprotectin and lactoferrin; and mucosal biomarkers such as mucosal cytokines and chemokines (e.g., IL-1, IL-1β, IL-4 IL-6, IL-8, IL-10, IL-11, IL13Rα2, IL-15, IL-18, IL-21, IL-23, IL-32, IFN-γ, TNF-α), monocyte chemotactic protein (MCP)-1, RANTES, epithelial neutrophil activating protein 78 (ENA-78)), osteoprotegerin, STC1, PTGS2, IL13Rα2, RelA, A20, pIgR (polymeric immunoglobulin receptor), GR (glucocorticosteroid receptor) expression, CXCL2, CXCL8, CXCL10, calgranulin B, adhesion molecules and markers of activation (e.g., mucosal vascular addressin CAM-1 (MAdCAM-1), NF-κB, mitogen-activated protein kinase (MAPK), ICAM-1, CD40 overexpression, increased phosphorylation of MAPKs (e.g., p38, extracellular signal-regulated kinase and Jun N-terminal kinase)), immune cells (e.g., IL-17-positive cells, TH17 cells, Tregs (regulatory T-cells), neutrophils, monocytes, mucosal dendritic cells, macrophages), non-immune cells (e.g., intestinal epithelial cells with abnormal HLA-DR and/or B7 molecule expression, endothelial cells with high expression of CD146, TLR3, TLR4), matrix metalloproteinases, vascular endothelial growth factor, other mucosal components (e.g., lactate dehydrogenase (LDH) isoenzyme M monomers, LDH 5 monomers, proliferator-activated receptor-2 (PAR2) methylation), mucin 2), and mean histological inflammation.", "In particular disclosed embodiments, a method for inhibiting or preventing a disease is contemplated, wherein the method comprises diagnosing a subject in need of treatment for a disease, administering to the subject a compound in an amount effective to inhibit and/or prevent the disease, the compound being selected from any one of the compounds disclosed herein, and permitting the compound to achieve therapeutic benefit for the disease in the subject.", "In certain embodiments, the disease is an inflammatory bowel disease including, but not limited to, ulcerative colitis, Crohn's disease, lymphocytic colitis, or collagenous colitis.", "In particular disclosed embodiments, the method comprises administering one or more disclosed embodiments of the compound, or compositions thereof, to a subject in an amount effective to inhibit or prevent a disease.", "The compound may have any one of formulas I-IV, such as any one of the exemplary compounds disclosed in Table 1.In some examples, the disease is an inflammatory bowel disease, such as ulcerative colitis.", "Typically, administering comprises exposing the subject to a first dose of the one or more compounds, or composition comprising the one or more compounds.", "The method may further comprise determining a therapeutic blood level of the one or more compounds in the subject, or a therapeutic metabolite blood level of the one or more compounds, in the subject.", "Additionally, the method may comprise, after determining the therapeutic blood level, adjusting the first dose to a second dose to optimize therapeutic effect.", "A single compound may be administered serially in plural administrations to the subject, or two or more compounds may be administered either serially or in combination to the subject.", "In particular disclosed embodiments, the one or more compounds are administered as a pharmaceutical composition.", "Suitable methods of administration include oral, buccal, mucosal, sublingual, parenteral (e.g., intravenous, intraperitoneal, subcutaneous injection, infusion, implant), intra-arterial, intramuscular, subcutaneous, intraarticular, infusion, intrathecal, intraurethral, topical, subdermal, transdermal, intranasal, inhalation, pulmonary tract, intratracheal, intraocular, ocular, intraaural, vaginal, and rectal.", "In particular disclosed embodiments, the compound is administered parenterally, orally, or rectally.", "The compound may be administered prophylactically.", "The method further may comprise administering a second therapeutic agent to the subject.", "The second therapeutic may be selected from an analgesic, an antibiotic, an antibody, an anticoagulant, an anti-inflammatory, an immunosuppressant, or combinations thereof.", "In particular disclosed embodiments, the second therapeutic is administered prior to or subsequent to the one or more compounds.", "In other embodiments, the second therapeutic is administered in combination with the one or more compounds.", "The second therapeutic may be selected from any of those disclosed herein.", "The second therapeutic also may be any other therapeutic that may have a beneficial effect for treating or preventing the disease and/or one or more symptoms associated therewith.", "V. Examples Example 1 Inhibition of IL-13 Signaling This example describes the effect of exemplary compounds on IL-13 signaling induced ICAM-1 expression and Stat6 phosphorylation in human small airway epithelial cells (SAEC).", "Exemplary compounds A1-A12 inhibited IL-13 signaling in this example with an EC50 of less than or equal to 100 nM.", "In parallel experiments, the compounds similarly inhibited IL-4 signaling.", "Icam-1 Expression: Primary human small airway epithelial cells (SAEC) were pre-incubated with compound for 1 hour prior to stimulation IL-13 or IL-4 for 20 hours.", "The surface expression of ICAM-1 was measured by flow cytometry.", "Materials Small Airway Epithelial Cells (SAEC) (LONZA, Cat# CC-2547) Small Airway Epithelial Cell Growth Medium SAGM BulletKit™ (LONZA, Cat# CC-3118) ReagentPack™ Subculture Reagents (LONZA, Cat# CC-5034) Dimethyl Sulfoxide (DMSO) (Sigma-Aldrich, Cat# D2650) Human IL-13 (Peprotech, Cat#200-13) Human IL-4 (Peprotech, Cat# AF-200-04) FACS buffer: PBS+2% FBS (4° C.) ICAM-1-APC antibody (BD Biosciences, Cat#559771) Method SAEC were seeded at 2×105 cells/100 μL/well in a flat bottom 96-well plate.", "Compound was serially diluted in DMSO from 5 mM in 3-fold dilutions, and then diluted 3:125 in SAGM.", "10 μL of 12× compound was added to the cells per well in duplicate and were preincubated for 1 hour at 37° C., 5% CO2.Cells were then stimulated with 10 μL 12× IL-13 (12.5 ng/mL final) for 20 hours at 37° C., 5% CO2.The media was removed and the cells were briefly trypsinized, the trypsin neutralized with media, and the cells transferred to a round-bottom plate and washed in FACS buffer.", "The cells were stained for 20 min at 4° C. with 50 μL/well of anti-ICAM-1-APC antibody diluted 1:100 in FACS buffer.", "The cells were washed with 150 μL of ice-cold FACS buffer, and resuspended in 100 μL of ice-cold FACS buffer for FACS analysis.", "Stat6 Phosphorylation: Primary human small airway epithelial cells (SAEC) were pre-incubated with compound for 1 hour prior to stimulation with IL-13 for 15 minutes and phosphorylation of Stat6 was measured by intracellular flow cytometry.", "Materials Small Airway Epithelial Cells (SAEC) (LONZA, Cat# CC-2547) Small Airway Epithelial Cell Growth Medium SAGM BulletKit™ (LONZA, Cat# CC-3118) ReagentPack™ Subculture Reagents (LONZA, Cat# CC-5034) Dimethyl Sulfoxide (DMSO) (Sigma-Aldrich, Cat# D2650) Human IL-13 (Peprotech, Cat#200-13) Human IL-4 (Peprotech, Cat# AF-200-04) 3.2% para-Formaldehyde (VWR, Cat# AA43368-9M) Anti-Phospho Stat-6-AlexaFluor488 (pY641) (BD bioscience, Cat#558243) FACS buffer: PBS+2% FBS (4° C.) Method SAEC were seeded at 2×105 cells/100 μl/well in a flat bottom 96-well plate.", "Compound was serially diluted in DMSO from 5 mM in 3-fold dilutions, and then diluted 3:125 in SAGM.", "10 μL of 12× compound was added to the cells per well in duplicate and were preincubated for 1 hour at 37° C., 5% CO2.Cells were then stimulated with 10 μL 12× IL-13 (10 ng/mL final) for 15 minutes at 37° C., 5% CO2.The media was removed and the cells were briefly trypsinized, the trypsin neutralized with media, and the cells transferred to a round-bottom plate and washed in PBS.", "The cells were fixed by addition of 100 μL 3.2% paraformaldehyde in PBS for 15 minutes at room temperature.", "The cells were spun down for 5 minutes at 1000 rpm and the supernatant was discarded.", "The cells were permeabilized in 200 μL ice-cold methanol for 30 minutes at 4° C. then washed once with 200 μL of FACS buffer.", "Phospho-Stat6 was detected by staining the cells with 50 μL of AlexaFluor488-labeled anti-phospho-Stat6 antibody, diluted 1:100 in FACS buffer.", "Staining was carried out overnight at room temperature in the dark.", "The cells were washed in FACS buffer and the level of Stat6 phosphorylation was determined by FACS.", "Example 2 Assay for Human Primary T-Cell Proliferation Stimulated by IL-2 Primary human T-cells derived from peripheral blood and pre-activated through stimulation of the T-cell receptor and CD28, proliferate in vitro in response to the cytokine Interleukin-2 (IL-2).", "This proliferative response is dependent on the activation of JAK-1 and JAK-3 tyrosine kinases, which phosphorylate and activate the transcription factor Stat-5.Human primary T-cells were prepared as follows.", "Whole blood was obtained from a healthy volunteer, mixed 1:1 with PBS, layered on to Ficoll Hypaque (Amersham Pharmacia Biotech, Piscataway, N.J., Catalog #17-1440-03) in 2:1 blood/PBS:ficoll ratio and centrifuged for 30 min at 4° C. at 1750 rpm.", "The lymphocytes at the serum: ficoll interface were recovered and washed twice with 5 volumes of PBS.", "The cells were resuspended in Yssel's medium (Gemini Bio-products, Woodland, Calif., Catalog #400-103) containing 40 U/mL recombinant IL2 (R and D Systems, Minneapolis, Minn., Catalog #202-IL (20 μg)) and seeded into a flask pre-coated with 1 μg/mL anti-CD3 (BD Pharmingen, San Diego, Calif., Catalog #555336) and g/mL anti-CD28 (Immunotech, Beckman Coulter of Brea Calif., Catalog #IM1376).", "The primary T-cells were stimulated for 3-4 days, then transferred to a fresh flask and maintained in RPMI with 10% FBS and 40 U/mL IL-2.The day prior to the assay set up, primary T-cells were centrifuged and resuspended in fresh RPMI with 10% FBS but without IL-2 and starved overnight.", "For the assay, the primary T-cells were centrifuged and resuspended Yssel's medium at 2×106 cells/mL.", "50 μL of cell suspension containing 80 U/mL IL-2 was added to each well of a flat bottom 96 well black plate.", "For the unstimulated control, IL-2 was omitted from the last column on the plate.", "Compounds were serially diluted in dimethyl sulfoxide (DMSO, 99.7% pure, cell culture tested, Sigma-Aldrich, St. Louis, Mo., Catalog No.", "D2650) from 5 mM in 3-fold dilutions, and then diluted 1:250 in Yssel's medium.", "50 μL of 2× compound was added per well in duplicate and the cells were allowed to proliferate for 72 hours at 37° C. Proliferation was measured using CellTiter-Glo® Luminescent Cell Viability Assay (Promega), which determines the number of viable cells in culture based on quantitation of the ATP present, as an indicator of metabolically active cells.", "The substrate was thawed and allowed to come to ambient temperature.", "After mixing the Cell Titer-Glo reagent and diluent together, 100 μL was added to each well.", "The plates were mixed on an orbital shaker for two minutes to induce lysis and incubated at ambient temperature for an additional ten minutes to allow the signal to equilibrate.", "Detection was performed using a Wallac Victor2 1420 multilabel counter purchased from Perkin Elmer, Shelton, Conn.", "The effectiveness of compounds A1-A18 to inhibit JAK3 activity, when tested under the conditions described above, are shown in Table 2 below.", "In Table 2, the activity is indicated by the following ranges: “A” represents compounds having an IC50<0.5 μM; “B” represents compounds having an IC50≥0.5 M and <5 μM; and “--” represents no data available.", "TABLE 2 Compound Activity A1 A A2 A A3 A A4 — A5 A A6 A A7 A A8 A A9 — A10 A A11 A A12 A A13 A A14 A A15 B A16 B A17 B A18 B I-432 A Example 3 Methods of Treatment A subject in need of treatment for an inflammatory bowel disease is selected based on a clinical, diagnostic, and/or histopathological presentation of inflammatory bowel disease.", "For example, the subject may have symptoms of inflammatory bowel disease, such as abdominal pain, abdominal cramps, bloody diarrhea, vomiting, pelvic muscle spasms, and/or fever.", "Inflammatory bowel disease also may be determined by diagnostic tests and/or procedures, such as blood tests (e.g., to check for infection or antibodies characteristic of an inflammatory bowel disease), stool analysis, colonoscopy, flexible sigmoidoscopy, barium enema, abdominal x-ray, computerized tomography scan, magnetic resonance imaging, capsule endoscopy, and/or double-balloon endoscopy.", "Subjects also may be selected based on an increased risk of developing inflammatory bowel disease, such as a family history of inflammatory bowel disease and/or one or more genetic markers indicating a predisposition toward developing an inflammatory bowel disease.", "The subject is administered a therapeutically effective dose of one or more of the compounds disclosed herein, or a pharmaceutical composition comprising one or more of the disclosed compounds.", "Administration may be performed via any suitable route including, but not limited to, parenteral (e.g., intravenous, intraperitoneal, implant), oral, or rectal routes.", "Treatment may be continued for at least a week, month, or year, and in some subjects treatment may extend over multiple years, the duration of disease, or the lifetime of the subject.", "Beneficial or desired results of treatment can include one or more, but are not limited to, alleviation or amelioration of one or more symptoms, diminishment of extent of the inflammatory bowel disease, stabilized (i.e., not worsening) state of the subject's condition, delay or slowing of the condition, including disease progression, amelioration or palliation of the condition, and remission (whether partial or total), whether detectable or undetectable.", "In particular cases, subjects are selected for concomitant treatment with other pharmaceutical or non-pharmaceutical interventions, such as an analgesic, an antibiotic, an anticoagulant, an antibody, an anti-inflammatory agent, an immunosuppressant, or a combination thereof.", "In other cases, at least one embodiment of the disclosed compounds, or a pharmaceutical composition comprising the compound, is administered to the subject with no other treatment for the inflammatory bowel disease.", "In view of the many possible embodiments to which the principles of the disclosed invention may be applied, it should be recognized that the illustrated embodiments are only preferred examples of the invention and should not be taken as limiting the scope of the invention.", "Rather, the scope of the invention is defined by the following claims.", "We therefore claim as our invention all that comes within the scope and spirit of these claims." ] ]
Patent_15875897
[ [ "METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES", "The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing.", "Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing." ], [ "1.A method for analyzing an analyte in a cell, comprising: (a) providing a plurality of partitions, wherein a given partition of said plurality of partitions comprises a plurality of analytes and a plurality of barcode molecules coupled to a bead, wherein (i) a first barcode molecule of said plurality of barcode molecules comprises a first nucleic acid barcode sequence capable of coupling to a first analyte of said plurality of analytes, wherein said first analyte is a CRISPR ribonucleic acid (crRNA) or a single guide ribonucleic acid (sgRNA), and wherein (ii) a second barcode molecule of said plurality of barcoded molecules comprises a second nucleic acid barcode sequence capable of coupling to a second analyte of said plurality of analytes; (b) in said given partition, (i) coupling said first barcode molecule to said first analyte or a derivative thereof, and synthesizing a first nucleic acid molecule comprising at least a portion of said first nucleic acid barcode sequence or a complement thereof and a sequence of said first analyte or a complement thereof; and (ii) coupling said second barcode molecule to said second analyte or a derivative thereof, and synthesizing a second nucleic acid molecule comprising at least a portion of said second nucleic acid barcode sequence or complement thereof and a sequence of said second analyte or complement thereof; (c) processing (i) said first nucleic acid molecule or a derivative thereof and (ii) said second nucleic acid molecule or a derivative thereof, to identify said at least said portion of said first nucleic acid barcode sequence and said at least said portion of said second nucleic acid barcode sequence; and (d) using said at least said portion of said first nucleic acid barcode sequence and said at least said portion of said second nucleic acid barcode sequence to identify said first analyte and said second analyte as originating from said cell.", "2.The method of claim 1, further comprising removing said first nucleic acid molecule and said second nucleic acid molecule, or a derivative of said first nucleic acid molecule and/or said second nucleic acid molecule, from said given partition.", "3.The method of claim 1, wherein, after (a), said first barcode molecule and/or said second barcode molecule is released from said bead.", "4.The method of claim 1, further comprising subjecting said first nucleic acid molecule and said second nucleic acid molecule, or a derivative of said first nucleic acid molecule and/or said second nucleic acid molecule, to sequencing to characterize said first analyte or said second analyte.", "5.The method of claim 1, wherein said first barcode molecule or said second barcode molecule comprises a unique molecular identification (UMI) sequence.", "6.The method of claim 1, wherein (i) said first barcode molecule comprises a first priming sequence capable of hybridizing to said first analyte, or a derivative thereof; (ii) said second barcode molecule comprises a second priming sequence capable of hybridizing to said second analyte, or a derivative thereof; or (iii) said first barcode molecule comprises a first priming sequence capable of hybridizing to said first analyte, or a derivative thereof, and said second barcode molecule comprises a second priming sequence capable of hybridizing to said second analyte, or a derivative thereof.", "7.The method of claim 6, wherein said second priming sequence comprises a poly-deoxythymine (poly(dT)) sequence.", "8.The method of claim 6, wherein said first analyte comprises an adapter sequence complementary to said first priming sequence.", "9.The method of claim 6, wherein said first priming sequence is complementary to a sequence in said crRNA or complementary to a sequence in said sgRNA.", "10.The method of claim 1, wherein said second analyte is messenger ribonucleic acid (mRNA).", "11.The method of claim 1, wherein said second analyte is genomic deoxyribonucleic acid (gDNA).", "12.The method of claim 1, wherein said second analyte is a labelling agent capable of coupling to a protein.", "13.The method of claim 1, wherein said first nucleic acid barcode sequence and said second nucleic barcode sequence are identical.", "14.The method of claim 1, wherein said bead is a gel bead.", "15.The method of claim 14, wherein said plurality of barcode molecules is reversibly coupled to said gel bead.", "16.The method of claim 15, wherein said plurality of barcode molecules is reversibly coupled to said gel bead through chemical cross-links.", "17.The method of claim 15, wherein said plurality of barcode molecules is reversibly coupled to said gel bead through disulfide bonds.", "18.The method of claim 15, wherein said given partition further comprises an agent capable of releasing said first barcode molecule or said second barcode from said bead.", "19.The method of claim 18, wherein said agent comprises a reducing agent.", "20.The method of claim 1, wherein said given partition is a droplet among a plurality of droplets.", "21.The method of claim 1, wherein said given partition is a well among a plurality of wells.", "22.The method of claim 2, further comprising performing one or more reactions subsequent to removing said first nucleic acid molecule and said second nucleic acid molecule from said given partition.", "23.The method of claim 15, wherein, after (a), said first barcode molecule and said second barcode molecule are released from said bead.", "24.The method of claim 15, wherein, before or during (b), said first barcode molecule or said second barcode molecule is released from said bead.", "25.The method of claim 1, wherein said plurality of partitions further comprise a template switching oligonucleotide (TSO) and wherein, in (b), synthesizing said first nucleic acid molecule or synthesizing said second nucleic acid molecule, or a derivative of said first nucleic acid molecule or said second nucleic acid molecule, includes the use of said template switching oligonucleotide.", "26.The method of claim 25, wherein said TSO comprises a primer sequence and wherein said first nucleic acid molecule or said second nucleic acid molecule, or a derivative of said first nucleic acid molecule or said second nucleic acid molecule, comprise said TSO primer sequence.", "27.The method of claim 1, wherein said plurality of partitions comprise a plurality of cells, wherein at least a subset of said plurality of cells comprise one or more sgRNAs, and wherein said given partition of said plurality of partitions comprises a cell comprising said one or more sgRNAs.", "28.The method of claim 27, wherein said given partition of said plurality of partitions comprises a single cell." ], [ "<SOH> BACKGROUND <EOH>Significant advances in analyzing and characterizing biological and biochemical materials and systems have led to unprecedented advances in understanding the mechanisms of life, health, disease and treatment.", "Among these advances, technologies that target and characterize the genomic make up of biological systems have yielded some of the most groundbreaking results, including advances in the use and exploitation of genetic amplification technologies, and nucleic acid sequencing technologies.", "Nucleic acid sequencing can be used to obtain information in a wide variety of biomedical contexts, including diagnostics, prognostics, biotechnology, and forensic biology.", "Sequencing may involve basic methods including Maxam-Gilbert sequencing and chain-termination methods, or de novo sequencing methods including shotgun sequencing and bridge PCR, or next-generation methods including polony sequencing, 454 pyrosequencing, Illumina sequencing, SOLiD sequencing, Ion Torrent semiconductor sequencing, HeliScope single molecule sequencing, SMRT® sequencing, and others.", "Nucleic acid sequencing technologies, including next-generation DNA sequencing, have been useful for genomic and proteomic analysis of cell populations." ], [ "<SOH> SUMMARY <EOH>Recognized herein is the need for methods, compositions and systems for analyzing genomic and proteomic information from individual cells or a small population of cells.", "Such cells include, but are not limited to, cancer cells, fetal cells, and immune cells involved in immune responses.", "Provided herein are methods, compositions and systems for analyzing individual cells or a small population of cells, including the analysis and attribution of nucleic acids and proteins from and to these individual cells or cell populations.", "In an aspect, the present disclosure provides a method of characterizing a cell.", "The method comprises (a) providing a partition comprising a cell and at least one labelling agent, wherein the at least one labelling agent is (i) capable of binding to a cell surface feature of the cell and (ii) is coupled to a reporter oligonucleotide comprising a nucleic acid barcode sequence that permits identification of the at least one labelling agent, wherein the partition comprises an anchor oligonucleotide that is capable of interacting with the reporter oligonucleotide barcode; (b) in the partition, synthesizing a nucleic acid molecule comprising at least a portion of the nucleic acid barcode sequence or a complement thereof; and (c) subjecting the nucleic acid molecule to sequencing to identify the labelling agent or the cell.", "In some embodiments, in (a), the at least one labelling agent is bound to the cell surface feature.", "In some embodiments, prior to (a), the at least one labelling agent is subjected to conditions suitable for binding the at least one labelling agent to the cell surface feature.", "In some embodiments, subjecting the at least one labelling agent to the conditions suitable for binding the at least one labelling agent to the cell surface feature is performed when the cell and the at least one labelling agent are free from the partition.", "In some embodiments, prior to (a), the at least one labelling agent is coupled to the reporter oligonucleotide.", "In some embodiments, in (b), the reporter oligonucleotide is subjected to a primer extension reaction that generates the nucleic acid molecule.", "In some embodiments, the primer extension reaction comprises subjecting the reporter oligonucleotide to conditions suitable to hybridize the anchor oligonucleotide to the reporter oligonucleotide and extend the anchor oligonucleotide using the reporter oligonucleotide as a template.", "In some embodiments, in (b), the anchor oligonucleotide is coupled to a bead.", "In some embodiments, in (b), the anchor oligonucleotide is coupled to a bead and the method further comprises releasing the anchor oligonucleotide from the bead prior to the synthesizing.", "In some embodiments, the bead is a gel bead.", "In some embodiments, the releasing comprises subjecting the bead to a stimulus that degrades the bead.", "In some embodiments, the stimulus is a chemical stimulus.", "In some embodiments, the bead comprises at least about 1,000 copies of the anchor oligonucleotide.", "In some embodiments, the bead comprises at least about 10,000 copies of the anchor oligonucleotide.", "In some embodiments, the bead comprises at least about 100,000 copies of the anchor oligonucleotide.", "In some embodiments, prior to (c), the nucleic acid molecule is released from the partition.", "In some embodiments, (c) comprises identifying the at least one labelling agent.", "In some embodiments, (c) comprises identifying the cell surface feature from identifying the at least one labelling agent.", "In some embodiments, (c) comprises determining an abundance of the given cell surface feature on the cell.", "In some embodiments, (c) comprises identifying the cell.", "In some embodiments, (c) comprises identifying the at least one labelling agent and the cell.", "In some embodiments, the reporter oligonucleotide comprises a unique molecular identification (UMI) sequence.", "In some embodiments, the UMI sequence permits identification of the cell.", "In some embodiments, (c) comprises determining a sequence of the UMI sequence and identifying the cell.", "In some embodiments, the partition is a droplet in an emulsion.", "In some embodiments, the at least one labelling agent is selected from the group comprising of an antibody, an antibody fragment, a cell surface receptor binding molecule, a receptor ligand, a small molecule, a bi-specific antibody, a bi-specific T-cell engager, a T-cell receptor engager, a B-cell receptor engager, a pro-body, an aptamer, a monobody, an affimer, a darpin, a protein scaffold, an antigen, an antigen presenting particle and a major histocompatibility complex (MHC).", "In some embodiments, the cell surface feature is selected from the group comprising of a receptor, an antigen, a surface protein, a transmembrane protein, a cluster of differentiation protein, a protein channel, a protein pump, a carrier protein, a phospholipid, a glycoprotein, a glycolipid, a cell-cell interaction protein complex, an antigen-presenting complex, a major histocompatibility complex, an engineered T-cell receptor, a T-cell receptor, a B-cell receptor, a chimeric antigen receptor, a gap junction, and an adherens junction.", "In some embodiments, the partition comprises only one cell.", "In some embodiments, the cell is bound to at least one of the at least one labelling agent.", "In some embodiments, the at least one of the at least one labelling agent comprises at least two of the same labelling agent.", "In some embodiments, the at least one of the at least one labelling agent comprises at least two different labelling agents.", "In some embodiments, the cell is bound to at least about 5 different labelling agents.", "In some embodiments, the cell is bound to at least about 10 different labelling agents.", "In some embodiments, the cell is bound to at least about 50 different labelling agents.", "In some embodiments, the cell is bound to at least about 100 different labelling agents.", "In some embodiments, the (c) comprises determining an identity of at least a subset of the different labelling agents.", "In some embodiments, the method further comprises (i) liberating nucleic acid from the cell and (ii) subjecting the nucleic acid or a derivative thereof to sequencing.", "In some embodiments, the nucleic acid is liberated from the cell into the partition.", "In an aspect, the present disclosure provides a system for characterizing a cell.", "The system comprises an electronic display screen comprising a user interface that displays a graphical element that is accessible by a user to execute a protocol to characterize the cell; and a computer processor coupled to the electronic display screen and programmed to execute the protocol upon selection of the graphical element by the user, which protocol comprises: (a) providing a partition comprising a cell and at least one labelling agent, wherein the at least one labelling agent is (i) capable of binding to a cell surface feature of the cell and (ii) is coupled to a reporter oligonucleotide comprising a nucleic acid barcode sequence that permits identification of the at least one labelling agent, wherein the partition comprises an anchor oligonucleotide that is capable of interacting with the reporter oligonucleotide barcode; (b) in the partition, synthesizing a nucleic acid molecule comprising at least a portion of the nucleic acid barcode sequence or a complement thereof; and (c) subjecting the nucleic acid molecule to sequencing to identify the labelling agent or the cell.", "In some embodiments, in protocol (a), the at least one labelling agent is bound to the cell surface feature.", "In some embodiments, prior to protocol (a), the at least one labelling agent is subjected to conditions suitable for binding the at least one labelling agent to the cell surface feature.", "In some embodiments, subjecting the at least one labelling agent to the conditions suitable for binding the at least one labelling agent to the cell surface feature is performed when the cell and the at least one labelling agent are free from the partition.", "In some embodiments, prior to protocol (a), the at least one labelling agent is coupled to the reporter oligonucleotide.", "In some embodiments, in protocol (b), the reporter oligonucleotide is subjected to a primer extension reaction that generates the nucleic acid molecule.", "In some embodiments, the primer extension reaction comprises subjecting the reporter oligonucleotide to conditions suitable to hybridize the anchor oligonucleotide to the reporter oligonucleotide and extend the anchor oligonucleotide using the reporter oligonucleotide as a template.", "In some embodiments, in protocol (b), the anchor oligonucleotide is coupled to a bead.", "In some embodiments, in (b), the anchor oligonucleotide is coupled to a bead and the method further comprises releasing the anchor oligonucleotide from the bead prior to the synthesizing.", "In some embodiments, the bead is a gel bead.", "In some embodiments, the releasing comprises subjecting the bead to a stimulus that degrades the bead.", "In some embodiments, the stimulus is a chemical stimulus.", "In some embodiments, the bead comprises at least about 1,000 copies of the anchor oligonucleotide.", "In some embodiments, the bead comprises at least about 10,000 copies of the anchor oligonucleotide.", "In some embodiments, the bead comprises at least about 100,000 copies of the anchor oligonucleotide.", "In some embodiments, prior to protocol (c), the nucleic acid molecule is released from the partition.", "In some embodiments, protocol (c) comprises identifying the at least one labelling agent.", "In some embodiments, protocol (c) comprises identifying the cell surface feature from identifying the at least one labelling agent.", "In some embodiments, protocol (c) comprises determining an abundance of the given cell surface feature on the cell.", "In some embodiments, protocol (c) comprises identifying the cell.", "In some embodiments, protocol (c) comprises identifying the at least one labelling agent and the cell.", "In some embodiments, the reporter oligonucleotide comprises a unique molecular identification (UMI) sequence.", "In some embodiments, the UMI sequence permits identification of the cell.", "In some embodiments, protocol (c) comprises determining a sequence of the UMI sequence and identifying the cell.", "In some embodiments, the partition is a droplet in an emulsion.", "In some embodiments, the at least one labelling agent is selected from the group comprising of an antibody, an antibody fragment, a cell surface receptor binding molecule, a receptor ligand, a small molecule, a bi-specific antibody, a bi-specific T-cell engager, a T-cell receptor engager, a B-cell receptor engager, a pro-body, an aptamer, a monobody, an affimer, a darpin, a protein scaffold, an antigen, an antigen presenting particle and a major histocompatibility complex (MHC).", "In some embodiments, the cell surface feature is selected from the group comprising of a receptor, an antigen, a surface protein, a transmembrane protein, a cluster of differentiation protein, a protein channel, a protein pump, a carrier protein, a phospholipid, a glycoprotein, a glycolipid, a cell-cell interaction protein complex, an antigen-presenting complex, a major histocompatibility complex, an engineered T-cell receptor, a T-cell receptor, a B-cell receptor, a chimeric antigen receptor, a gap junction, and an adherens junction.", "In some embodiments, the partition comprises only one cell.", "In some embodiments, the cell is bound to at least one of the at least one labelling agent.", "In some embodiments, the at least one of the at least one labelling agent comprises at least two of the same labelling agent.", "In some embodiments, the at least one of the at least one labelling agent comprises at least two different labelling agents.", "In some embodiments, the cell is bound to at least about 5 different labelling agents.", "In some embodiments, the cell is bound to at least about 10 different labelling agents.", "In some embodiments, the cell is bound to at least about 50 different labelling agents.", "In some embodiments, the cell is bound to at least about 100 different labelling agents.", "In some embodiments, protocol (c) comprises determining an identity of at least a subset of the different labelling agents.", "In some embodiments, protocol comprises (i) liberating nucleic acid from the cell and (ii) subjecting the nucleic acid or a derivative thereof to sequencing.", "In some embodiments, the nucleic acid is liberated from the cell into the partition.", "An additional aspect of the disclosure provides a method for analyte characterization.", "The method includes: (a) providing a plurality of partitions, where a given partition of the plurality of partitions comprises a plurality of barcode molecules and a plurality of analytes.", "In some cases, the plurality of barcode molecules comprises at least 1,000 barcode molecules.", "In addition, (i) a first individual barcode molecule of the plurality of barcode molecules can comprise a first nucleic acid barcode sequence that is capable of coupling to a first analyte of the plurality of analytes, and (ii) a second individual barcode molecule of the plurality of barcoded molecules can comprise a second nucleic acid barcode sequence that is capable of coupling to a second analyte of the plurality of analytes where the first analyte and the second analyte are different types of analytes.", "The method also includes (b) in the given partition, (i) synthesizing a first nucleic acid molecule comprising at least a portion of the first nucleic acid barcode sequence or complement thereof, and (ii) synthesizing a second nucleic acid molecule comprising at least a portion of the second nucleic acid barcode sequence or complement thereof; and (c) removing the first nucleic acid molecule and the second nucleic acid molecule from the given partition.", "In some embodiments, the method further comprises subjecting the first nucleic acid molecule and the second nucleic acid molecule, or a derivative of the first nucleic acid molecule and/or the second nucleic acid molecule, to sequencing to characterize the first analyte and/or the second analyte.", "In some embodiments, the method further comprises repeating (a)-(c) based on a characterization of the first analyte or the second analyte from the sequencing.", "In some embodiments, the method further comprises selecting the first analyte or the second analyte based on a characterization of the first analyte or the second analyte obtained from the sequencing or a subsequent sequencing upon repeating (a)-(c).", "In some embodiments, (b) further comprises: (1) synthesizing the first nucleic acid molecule comprising at least a portion of the first nucleic acid barcode sequence or complement thereof, and (2) synthesizing the second nucleic acid molecule comprising at least a portion of the second nucleic acid barcode sequence or complement thereof.", "In some embodiments, the first analyte is a nucleic acid molecule, such as genomic deoxyribonucleic acid (gDNA) or messenger RNA (mRNA).", "In some embodiments, the first analyte is a labelling agent capable of coupling to a cell surface feature of a cell.", "In some embodiments, the first individual barcode molecule or the second individual barcode molecule is capable of coupling to the labelling agent via a third nucleic acid molecule coupled to the labelling agent.", "In some embodiments, the cell surface feature is a receptor, an antigen, or a protein.", "In some embodiments, the labelling agent is an antibody, an antibody fragment or a major histocompatibility complex (MHC).", "In some embodiments, the given partition comprises the cell or one or more components of the cell.", "In some embodiments, the given partition comprises a single cell.", "In some embodiments, the first nucleic acid molecule or the second nucleic molecule comprises a third barcode sequence.", "In some embodiments, the third barcode sequence is derived from a third nucleic acid molecule.", "In some embodiments, the third nucleic acid molecule is coupled to a labelling agent capable of binding to a cell surface feature of a cell.", "In some embodiments, the first analyte and second analyte are different types of nucleic acid molecules.", "In some embodiments, the first analyte is a ribonucleic acid molecule and the second analyte is a deoxyribonucleic acid molecule.", "In some embodiments, (i) the first individual barcode molecule comprises a first priming sequence capable of hybridizing to the first analyte; or (ii) the second individual barcode molecule comprises a second priming sequence capable of hybridizing to the second analyte.", "In some embodiments, the first barcode molecule or the second barcode molecule comprises a unique molecular identification (UMI) sequence.", "In some embodiments, the first analyte is a nucleic acid molecule and the second analyte is a labelling agent capable of coupling to a cell surface feature.", "In some embodiments, the first analyte is a messenger ribonucleic acid molecule.", "In some embodiments, (i) the first individual barcode molecule comprises a first priming sequence capable of hybridizing to the first analyte; or (ii) the second individual barcode molecule comprises a second priming sequence capable of hybridizing to the labelling agent.", "In some embodiments, the labelling agent is an antibody, an antibody fragment, or a major histocompatibility complex (MHC).", "In some embodiments, the cell surface feature is selected from the group consisting of a receptor, an antigen, or a protein.", "In some embodiments, the first analyte comprises a nucleic acid molecule with a nucleic acid sequence or complement thereof that encodes at least a portion of a V(D)J sequence of an immune cell receptor.", "In some embodiments, the nucleic acid molecule is a messenger ribonucleic acid.", "In some embodiments, the nucleic acid molecule is complementary DNA (cDNA) derived from reverse transcription of an mRNA encoding the at least a portion of the V(D)J sequence.", "In some embodiments, the first analyte comprises a nucleic acid molecule with a nucleic acid sequence that is capable of functioning as a component of a gene editing reaction.", "In some embodiments, the gene editing reaction comprises clustered regularly interspaced short palindromic repeats (CRISPR)-based gene editing.", "In some embodiments, at least one of the first individual barcode molecule and the second individual barcode molecule is coupled to a bead, such as a gel bead.", "The bead can be degradable.", "In some embodiments, the method further comprises, after (a), releasing the first individual barcode molecule or the second individual barcode from the bead.", "In some embodiments, the given partition further comprises an agent capable of releasing the first individual barcode molecule or the second individual barcode from the bead.", "In some embodiments, the given partition selected is a droplet among a plurality of droplets or a well among a plurality of wells.", "In some embodiments, the first nucleic acid barcode sequence and the second nucleic barcode sequence are identical.", "In some embodiments, the method further comprises performing one or more reactions subsequent to removing the first nucleic acid molecule and the second nucleic acid molecule from the given partition.", "Another aspect of the disclosure provides a composition for characterizing a plurality of analytes.", "The composition comprises a partition comprising a plurality of barcode molecules and the plurality of analytes.", "The plurality of barcode molecules can comprise at least 1,000 barcode molecules.", "In addition, (i) a first individual barcode molecule of the plurality of barcode molecules can comprise a first nucleic acid barcode sequence that is capable of coupling to a first analyte of the plurality of analytes; and (ii) a second individual barcode molecule of the plurality of barcoded molecules can comprise a second nucleic acid barcode sequence that is capable of coupling to a second analyte of the plurality of analytes, where the first analyte and the second analyte are different types of analytes.", "In some embodiments, the first analyte is a nucleic acid molecule, such as genomic deoxyribonucleic acid (gDNA) or is messenger RNA (mRNA).", "In some embodiments, the first analyte is a labelling agent capable of coupling to a cell surface feature of a cell.", "In some embodiments, the first individual barcode molecule or the second individual barcode molecule is capable of coupling to the labelling agent via a third nucleic acid molecule coupled to the labelling agent.", "In some embodiments, the cell surface feature is a receptor, an antigen, or a protein.", "In some embodiments, the labelling agent is an antibody, an antibody fragment, an antibody fragment, or a major histocompatibility complex (MHC).", "In some embodiments, the partition comprises the cell or one or more components of the cell.", "In some embodiments, the partition comprises a single cell.", "In some embodiments, the first nucleic acid molecule or the second nucleic molecule comprises a third barcode sequence.", "In some embodiments, the third barcode sequence is derived from a third nucleic acid molecule.", "In some embodiments, the third nucleic acid molecule is coupled to a labelling agent capable of binding to a cell surface feature of a cell.", "In some embodiments, the first analyte and second analyte are different types nucleic acid molecules.", "In some embodiments, the first analyte is a ribonucleic acid molecule and the second analyte is a deoxyribonucleic acid molecule.", "In some embodiments, (i) the first individual barcode molecule comprises a first priming sequence capable of hybridizing to the first analyte; or (ii) the second individual barcode molecule comprises a second priming sequence capable of hybridizing to the second analyte.", "In some embodiments, the first barcode molecule or the second barcode molecule comprises a unique molecular identification (UMI) sequence.", "In some embodiments, the first analyte is a nucleic acid molecule and the second analyte is a labelling agent capable of coupling to a cell surface feature.", "In some embodiments, the first analyte is a ribonucleic acid molecule.", "In some embodiments, (i) the first individual barcode molecule comprises a first priming sequence capable of hybridizing to the first analyte; or (ii) the second individual barcode molecule comprises a second priming sequence capable of hybridizing to a third nucleic acid molecule coupled to the labelling agent.", "In some embodiments, the labelling agent is an antibody, an antibody fragment, or a major histocompatibility complex (MHC).", "In some embodiments, the cell surface feature is a receptor, an antigen, or a protein.", "In some embodiments, the first analyte comprises a nucleic acid molecule with a nucleic acid sequence or complement thereof that encodes at least a portion of a V(D)J sequence of an immune cell receptor.", "In some embodiments, the nucleic acid sequence is a ribonucleic acid molecule.", "In some embodiments, the nucleic acid molecule comprises a nucleic acid sequence that is complementary DNA (cDNA) derived from reverse transcription of an mRNA encoding the at least a portion of the V(D)J sequence.", "In some embodiments, the first analyte comprises a nucleic acid molecule with a nucleic acid sequence that is capable of functioning as a component of a gene editing reaction.", "In some embodiments, the gene editing reaction comprises clustered regularly interspaced short palindromic repeats (CRISPR)-based gene editing.", "In some embodiments, at least one of the first individual barcode molecule and the second individual barcode molecule is coupled to a bead, such as a gel bead.", "The bead may be degradable.", "In some embodiments, the given partition further comprises an agent capable of releasing the first individual barcode molecule or the second individual barcode from the bead.", "In some embodiments, the given partition is a droplet among a plurality of droplets or a well among a plurality of wells.", "In some embodiments, the first nucleic acid barcode sequence and the second nucleic barcode sequence are identical.", "An additional aspect of the disclosure provides a system for characterizing a plurality of analytes.", "The system comprises a partitioning unit for providing a partition comprising a plurality of barcode molecules and the plurality of analytes, where: (i) a first individual barcode molecule of the plurality of barcode molecules comprises a first nucleic acid barcode sequence and is capable of coupling to a first analyte of the plurality of analytes; and (ii) a second individual barcode molecule of the plurality of barcode molecules comprises a second nucleic acid barcode sequence and is capable of coupling to a second analyte of the plurality of analytes, where the first analyte and the second analyte are different types of analytes.", "The system also includes a controller coupled to the partitioning unit, where the controller is programmed to (i) direct the partitioning unit to provide the partition; (ii) subject the partition to conditions that are sufficient to: (1) synthesize a first nucleic acid molecule comprising at least a portion of the first nucleic acid barcode sequence or complement thereof; and (2) synthesize a second nucleic acid molecule comprising at least a portion of the second nucleic acid barcode sequence or complement thereof, where sequencing of the first nucleic acid molecule and the second nucleic acid molecule, or derivatives thereof, characterizes the first analyte or the second analyte.", "In some embodiments, the partitioning unit comprises a plurality of channels.", "In some embodiments, the partitioning unit further comprises at least one channel junction, where the at least one channel junction is configured to provide the partition.", "In some embodiments, the system also includes (i) a first channel fluidically connected to the at least one channel junction and configured to provide a first fluid to the at least one channel junction; (ii) and a second channel fluidically connected to the at least one channel junction and configured to provide a second fluid, immiscible with the first fluid, to the at least one channel junction.", "In some embodiments, the first analyte is a nucleic acid molecule, such as genomic deoxyribonucleic acid (gDNA) or messenger RNA (mRNA).", "In some embodiments, the first analyte is a labelling agent capable of coupling to a cell surface feature of a cell.", "In some embodiments, the first individual barcode molecule or the second individual barcode molecule is capable of coupling to the labelling agent via a third nucleic acid molecule coupled to the labelling agent.", "In some embodiments, the cell surface feature is a receptor, an antigen, or a protein.", "In some embodiments, the labelling agent is an antibody, an antibody fragment, or a major histocompatibility complex (MHC).", "In some embodiments, the partition comprises the cell or one or more components of the cell.", "In some embodiments, the partition comprises a single cell.", "In some embodiments, the first nucleic acid molecule or the second nucleic molecule comprises a third barcode sequence.", "In some embodiments, the third barcode sequence is derived from a third nucleic acid molecule.", "In some embodiments, the third nucleic acid molecule is coupled to a labelling agent capable of binding to a cell surface feature of a cell.", "In some embodiments, the first analyte and second analyte are different types nucleic acid molecules.", "In some embodiments, the first analyte is a ribonucleic acid molecule and the second analyte is a deoxyribonucleic acid molecule.", "In some embodiments, (i) the first individual barcode molecule comprises a first priming sequence capable of hybridizing to the first analyte; or (ii) the second individual barcode molecule comprises a second priming sequence capable of hybridizing to the second analyte.", "In some embodiments, the first barcode molecule or the second barcode molecule comprises a unique molecular identification (UMI) sequence.", "In some embodiments, the first analyte is a nucleic acid molecule and the second analyte is a labelling agent capable of coupling to a cell surface feature.", "In some embodiments, the first analyte is a ribonucleic acid molecule.", "In some embodiments, (i) the first individual barcode molecule comprises a first priming sequence capable of hybridizing to the first analyte; or (ii) the second individual barcode molecule comprises a second priming sequence capable of hybridizing to a third nucleic acid molecule coupled to the labelling agent.", "In some embodiments, the labelling agent is an antibody, an antibody fragment, or a major histocompatibility complex (MHC).", "In some embodiments, the cell surface feature is a receptor, an antigen, or a protein.", "In some embodiments, the first analyte comprises a nucleic acid molecule with a nucleic acid sequence or complement thereof that encodes at least a portion of a V(D)J sequence of an immune cell receptor.", "In some embodiments, the nucleic acid sequence is a messenger ribonucleic acid molecule.", "In some embodiments, the nucleic acid molecule is complementary DNA (cDNA) derived from reverse transcription of an mRNA encoding the at least a portion of the V(D)J sequence.", "In some embodiments, the first analyte comprises a nucleic acid molecule with a nucleic acid sequence that is capable of functioning as a component of a gene editing reaction.", "In some embodiments, the gene editing reaction comprises clustered regularly interspaced short palindromic repeats (CRISPR)-based gene editing.", "In some embodiments, at least one of the first individual barcode molecule and the second individual barcode molecule is coupled to a bead, such as a gel bead.", "The bead may be degradable.", "In some embodiments, the partition further comprises an agent capable of releasing the first individual barcode molecule or the second individual barcode from the bead.", "In some embodiments, the partition is a droplet among a plurality of droplets or a well among a plurality of wells.", "In some embodiments, the nucleic acid barcode sequence and the second nucleic barcode sequence are identical.", "In some embodiments, the partition comprises at least 1,000 barcode molecules.", "Additional aspects and advantages of the present disclosure will become readily apparent to those skilled in this art from the following detailed description, wherein only illustrative embodiments of the present disclosure are shown and described.", "As will be realized, the present disclosure is capable of other and different embodiments, and its several details are capable of modifications in various obvious respects, all without departing from the disclosure.", "Accordingly, the drawings and description are to be regarded as illustrative in nature, and not as restrictive." ], [ "CROSS-REFERENCE This application is a continuation of U.S. patent application Ser.", "No.", "15/720,085, filed Sep. 29, 2017, which claims priority to U.S.", "Provisional Patent Application No.", "62/438,341, filed on Dec. 22, 2016.Each of the above-referenced applications are herein incorporated by reference in their entirety for all purposes.", "SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety.", "Said ASCII copy, created on Jan. 18, 2018, is named 43487742301SL.txt and is 22,715 bytes in size.", "BACKGROUND Significant advances in analyzing and characterizing biological and biochemical materials and systems have led to unprecedented advances in understanding the mechanisms of life, health, disease and treatment.", "Among these advances, technologies that target and characterize the genomic make up of biological systems have yielded some of the most groundbreaking results, including advances in the use and exploitation of genetic amplification technologies, and nucleic acid sequencing technologies.", "Nucleic acid sequencing can be used to obtain information in a wide variety of biomedical contexts, including diagnostics, prognostics, biotechnology, and forensic biology.", "Sequencing may involve basic methods including Maxam-Gilbert sequencing and chain-termination methods, or de novo sequencing methods including shotgun sequencing and bridge PCR, or next-generation methods including polony sequencing, 454 pyrosequencing, Illumina sequencing, SOLiD sequencing, Ion Torrent semiconductor sequencing, HeliScope single molecule sequencing, SMRT® sequencing, and others.", "Nucleic acid sequencing technologies, including next-generation DNA sequencing, have been useful for genomic and proteomic analysis of cell populations.", "SUMMARY Recognized herein is the need for methods, compositions and systems for analyzing genomic and proteomic information from individual cells or a small population of cells.", "Such cells include, but are not limited to, cancer cells, fetal cells, and immune cells involved in immune responses.", "Provided herein are methods, compositions and systems for analyzing individual cells or a small population of cells, including the analysis and attribution of nucleic acids and proteins from and to these individual cells or cell populations.", "In an aspect, the present disclosure provides a method of characterizing a cell.", "The method comprises (a) providing a partition comprising a cell and at least one labelling agent, wherein the at least one labelling agent is (i) capable of binding to a cell surface feature of the cell and (ii) is coupled to a reporter oligonucleotide comprising a nucleic acid barcode sequence that permits identification of the at least one labelling agent, wherein the partition comprises an anchor oligonucleotide that is capable of interacting with the reporter oligonucleotide barcode; (b) in the partition, synthesizing a nucleic acid molecule comprising at least a portion of the nucleic acid barcode sequence or a complement thereof; and (c) subjecting the nucleic acid molecule to sequencing to identify the labelling agent or the cell.", "In some embodiments, in (a), the at least one labelling agent is bound to the cell surface feature.", "In some embodiments, prior to (a), the at least one labelling agent is subjected to conditions suitable for binding the at least one labelling agent to the cell surface feature.", "In some embodiments, subjecting the at least one labelling agent to the conditions suitable for binding the at least one labelling agent to the cell surface feature is performed when the cell and the at least one labelling agent are free from the partition.", "In some embodiments, prior to (a), the at least one labelling agent is coupled to the reporter oligonucleotide.", "In some embodiments, in (b), the reporter oligonucleotide is subjected to a primer extension reaction that generates the nucleic acid molecule.", "In some embodiments, the primer extension reaction comprises subjecting the reporter oligonucleotide to conditions suitable to hybridize the anchor oligonucleotide to the reporter oligonucleotide and extend the anchor oligonucleotide using the reporter oligonucleotide as a template.", "In some embodiments, in (b), the anchor oligonucleotide is coupled to a bead.", "In some embodiments, in (b), the anchor oligonucleotide is coupled to a bead and the method further comprises releasing the anchor oligonucleotide from the bead prior to the synthesizing.", "In some embodiments, the bead is a gel bead.", "In some embodiments, the releasing comprises subjecting the bead to a stimulus that degrades the bead.", "In some embodiments, the stimulus is a chemical stimulus.", "In some embodiments, the bead comprises at least about 1,000 copies of the anchor oligonucleotide.", "In some embodiments, the bead comprises at least about 10,000 copies of the anchor oligonucleotide.", "In some embodiments, the bead comprises at least about 100,000 copies of the anchor oligonucleotide.", "In some embodiments, prior to (c), the nucleic acid molecule is released from the partition.", "In some embodiments, (c) comprises identifying the at least one labelling agent.", "In some embodiments, (c) comprises identifying the cell surface feature from identifying the at least one labelling agent.", "In some embodiments, (c) comprises determining an abundance of the given cell surface feature on the cell.", "In some embodiments, (c) comprises identifying the cell.", "In some embodiments, (c) comprises identifying the at least one labelling agent and the cell.", "In some embodiments, the reporter oligonucleotide comprises a unique molecular identification (UMI) sequence.", "In some embodiments, the UMI sequence permits identification of the cell.", "In some embodiments, (c) comprises determining a sequence of the UMI sequence and identifying the cell.", "In some embodiments, the partition is a droplet in an emulsion.", "In some embodiments, the at least one labelling agent is selected from the group comprising of an antibody, an antibody fragment, a cell surface receptor binding molecule, a receptor ligand, a small molecule, a bi-specific antibody, a bi-specific T-cell engager, a T-cell receptor engager, a B-cell receptor engager, a pro-body, an aptamer, a monobody, an affimer, a darpin, a protein scaffold, an antigen, an antigen presenting particle and a major histocompatibility complex (MHC).", "In some embodiments, the cell surface feature is selected from the group comprising of a receptor, an antigen, a surface protein, a transmembrane protein, a cluster of differentiation protein, a protein channel, a protein pump, a carrier protein, a phospholipid, a glycoprotein, a glycolipid, a cell-cell interaction protein complex, an antigen-presenting complex, a major histocompatibility complex, an engineered T-cell receptor, a T-cell receptor, a B-cell receptor, a chimeric antigen receptor, a gap junction, and an adherens junction.", "In some embodiments, the partition comprises only one cell.", "In some embodiments, the cell is bound to at least one of the at least one labelling agent.", "In some embodiments, the at least one of the at least one labelling agent comprises at least two of the same labelling agent.", "In some embodiments, the at least one of the at least one labelling agent comprises at least two different labelling agents.", "In some embodiments, the cell is bound to at least about 5 different labelling agents.", "In some embodiments, the cell is bound to at least about 10 different labelling agents.", "In some embodiments, the cell is bound to at least about 50 different labelling agents.", "In some embodiments, the cell is bound to at least about 100 different labelling agents.", "In some embodiments, the (c) comprises determining an identity of at least a subset of the different labelling agents.", "In some embodiments, the method further comprises (i) liberating nucleic acid from the cell and (ii) subjecting the nucleic acid or a derivative thereof to sequencing.", "In some embodiments, the nucleic acid is liberated from the cell into the partition.", "In an aspect, the present disclosure provides a system for characterizing a cell.", "The system comprises an electronic display screen comprising a user interface that displays a graphical element that is accessible by a user to execute a protocol to characterize the cell; and a computer processor coupled to the electronic display screen and programmed to execute the protocol upon selection of the graphical element by the user, which protocol comprises: (a) providing a partition comprising a cell and at least one labelling agent, wherein the at least one labelling agent is (i) capable of binding to a cell surface feature of the cell and (ii) is coupled to a reporter oligonucleotide comprising a nucleic acid barcode sequence that permits identification of the at least one labelling agent, wherein the partition comprises an anchor oligonucleotide that is capable of interacting with the reporter oligonucleotide barcode; (b) in the partition, synthesizing a nucleic acid molecule comprising at least a portion of the nucleic acid barcode sequence or a complement thereof; and (c) subjecting the nucleic acid molecule to sequencing to identify the labelling agent or the cell.", "In some embodiments, in protocol (a), the at least one labelling agent is bound to the cell surface feature.", "In some embodiments, prior to protocol (a), the at least one labelling agent is subjected to conditions suitable for binding the at least one labelling agent to the cell surface feature.", "In some embodiments, subjecting the at least one labelling agent to the conditions suitable for binding the at least one labelling agent to the cell surface feature is performed when the cell and the at least one labelling agent are free from the partition.", "In some embodiments, prior to protocol (a), the at least one labelling agent is coupled to the reporter oligonucleotide.", "In some embodiments, in protocol (b), the reporter oligonucleotide is subjected to a primer extension reaction that generates the nucleic acid molecule.", "In some embodiments, the primer extension reaction comprises subjecting the reporter oligonucleotide to conditions suitable to hybridize the anchor oligonucleotide to the reporter oligonucleotide and extend the anchor oligonucleotide using the reporter oligonucleotide as a template.", "In some embodiments, in protocol (b), the anchor oligonucleotide is coupled to a bead.", "In some embodiments, in (b), the anchor oligonucleotide is coupled to a bead and the method further comprises releasing the anchor oligonucleotide from the bead prior to the synthesizing.", "In some embodiments, the bead is a gel bead.", "In some embodiments, the releasing comprises subjecting the bead to a stimulus that degrades the bead.", "In some embodiments, the stimulus is a chemical stimulus.", "In some embodiments, the bead comprises at least about 1,000 copies of the anchor oligonucleotide.", "In some embodiments, the bead comprises at least about 10,000 copies of the anchor oligonucleotide.", "In some embodiments, the bead comprises at least about 100,000 copies of the anchor oligonucleotide.", "In some embodiments, prior to protocol (c), the nucleic acid molecule is released from the partition.", "In some embodiments, protocol (c) comprises identifying the at least one labelling agent.", "In some embodiments, protocol (c) comprises identifying the cell surface feature from identifying the at least one labelling agent.", "In some embodiments, protocol (c) comprises determining an abundance of the given cell surface feature on the cell.", "In some embodiments, protocol (c) comprises identifying the cell.", "In some embodiments, protocol (c) comprises identifying the at least one labelling agent and the cell.", "In some embodiments, the reporter oligonucleotide comprises a unique molecular identification (UMI) sequence.", "In some embodiments, the UMI sequence permits identification of the cell.", "In some embodiments, protocol (c) comprises determining a sequence of the UMI sequence and identifying the cell.", "In some embodiments, the partition is a droplet in an emulsion.", "In some embodiments, the at least one labelling agent is selected from the group comprising of an antibody, an antibody fragment, a cell surface receptor binding molecule, a receptor ligand, a small molecule, a bi-specific antibody, a bi-specific T-cell engager, a T-cell receptor engager, a B-cell receptor engager, a pro-body, an aptamer, a monobody, an affimer, a darpin, a protein scaffold, an antigen, an antigen presenting particle and a major histocompatibility complex (MHC).", "In some embodiments, the cell surface feature is selected from the group comprising of a receptor, an antigen, a surface protein, a transmembrane protein, a cluster of differentiation protein, a protein channel, a protein pump, a carrier protein, a phospholipid, a glycoprotein, a glycolipid, a cell-cell interaction protein complex, an antigen-presenting complex, a major histocompatibility complex, an engineered T-cell receptor, a T-cell receptor, a B-cell receptor, a chimeric antigen receptor, a gap junction, and an adherens junction.", "In some embodiments, the partition comprises only one cell.", "In some embodiments, the cell is bound to at least one of the at least one labelling agent.", "In some embodiments, the at least one of the at least one labelling agent comprises at least two of the same labelling agent.", "In some embodiments, the at least one of the at least one labelling agent comprises at least two different labelling agents.", "In some embodiments, the cell is bound to at least about 5 different labelling agents.", "In some embodiments, the cell is bound to at least about 10 different labelling agents.", "In some embodiments, the cell is bound to at least about 50 different labelling agents.", "In some embodiments, the cell is bound to at least about 100 different labelling agents.", "In some embodiments, protocol (c) comprises determining an identity of at least a subset of the different labelling agents.", "In some embodiments, protocol comprises (i) liberating nucleic acid from the cell and (ii) subjecting the nucleic acid or a derivative thereof to sequencing.", "In some embodiments, the nucleic acid is liberated from the cell into the partition.", "An additional aspect of the disclosure provides a method for analyte characterization.", "The method includes: (a) providing a plurality of partitions, where a given partition of the plurality of partitions comprises a plurality of barcode molecules and a plurality of analytes.", "In some cases, the plurality of barcode molecules comprises at least 1,000 barcode molecules.", "In addition, (i) a first individual barcode molecule of the plurality of barcode molecules can comprise a first nucleic acid barcode sequence that is capable of coupling to a first analyte of the plurality of analytes, and (ii) a second individual barcode molecule of the plurality of barcoded molecules can comprise a second nucleic acid barcode sequence that is capable of coupling to a second analyte of the plurality of analytes where the first analyte and the second analyte are different types of analytes.", "The method also includes (b) in the given partition, (i) synthesizing a first nucleic acid molecule comprising at least a portion of the first nucleic acid barcode sequence or complement thereof, and (ii) synthesizing a second nucleic acid molecule comprising at least a portion of the second nucleic acid barcode sequence or complement thereof; and (c) removing the first nucleic acid molecule and the second nucleic acid molecule from the given partition.", "In some embodiments, the method further comprises subjecting the first nucleic acid molecule and the second nucleic acid molecule, or a derivative of the first nucleic acid molecule and/or the second nucleic acid molecule, to sequencing to characterize the first analyte and/or the second analyte.", "In some embodiments, the method further comprises repeating (a)-(c) based on a characterization of the first analyte or the second analyte from the sequencing.", "In some embodiments, the method further comprises selecting the first analyte or the second analyte based on a characterization of the first analyte or the second analyte obtained from the sequencing or a subsequent sequencing upon repeating (a)-(c).", "In some embodiments, (b) further comprises: (1) synthesizing the first nucleic acid molecule comprising at least a portion of the first nucleic acid barcode sequence or complement thereof, and (2) synthesizing the second nucleic acid molecule comprising at least a portion of the second nucleic acid barcode sequence or complement thereof.", "In some embodiments, the first analyte is a nucleic acid molecule, such as genomic deoxyribonucleic acid (gDNA) or messenger RNA (mRNA).", "In some embodiments, the first analyte is a labelling agent capable of coupling to a cell surface feature of a cell.", "In some embodiments, the first individual barcode molecule or the second individual barcode molecule is capable of coupling to the labelling agent via a third nucleic acid molecule coupled to the labelling agent.", "In some embodiments, the cell surface feature is a receptor, an antigen, or a protein.", "In some embodiments, the labelling agent is an antibody, an antibody fragment or a major histocompatibility complex (MHC).", "In some embodiments, the given partition comprises the cell or one or more components of the cell.", "In some embodiments, the given partition comprises a single cell.", "In some embodiments, the first nucleic acid molecule or the second nucleic molecule comprises a third barcode sequence.", "In some embodiments, the third barcode sequence is derived from a third nucleic acid molecule.", "In some embodiments, the third nucleic acid molecule is coupled to a labelling agent capable of binding to a cell surface feature of a cell.", "In some embodiments, the first analyte and second analyte are different types of nucleic acid molecules.", "In some embodiments, the first analyte is a ribonucleic acid molecule and the second analyte is a deoxyribonucleic acid molecule.", "In some embodiments, (i) the first individual barcode molecule comprises a first priming sequence capable of hybridizing to the first analyte; or (ii) the second individual barcode molecule comprises a second priming sequence capable of hybridizing to the second analyte.", "In some embodiments, the first barcode molecule or the second barcode molecule comprises a unique molecular identification (UMI) sequence.", "In some embodiments, the first analyte is a nucleic acid molecule and the second analyte is a labelling agent capable of coupling to a cell surface feature.", "In some embodiments, the first analyte is a messenger ribonucleic acid molecule.", "In some embodiments, (i) the first individual barcode molecule comprises a first priming sequence capable of hybridizing to the first analyte; or (ii) the second individual barcode molecule comprises a second priming sequence capable of hybridizing to the labelling agent.", "In some embodiments, the labelling agent is an antibody, an antibody fragment, or a major histocompatibility complex (MHC).", "In some embodiments, the cell surface feature is selected from the group consisting of a receptor, an antigen, or a protein.", "In some embodiments, the first analyte comprises a nucleic acid molecule with a nucleic acid sequence or complement thereof that encodes at least a portion of a V(D)J sequence of an immune cell receptor.", "In some embodiments, the nucleic acid molecule is a messenger ribonucleic acid.", "In some embodiments, the nucleic acid molecule is complementary DNA (cDNA) derived from reverse transcription of an mRNA encoding the at least a portion of the V(D)J sequence.", "In some embodiments, the first analyte comprises a nucleic acid molecule with a nucleic acid sequence that is capable of functioning as a component of a gene editing reaction.", "In some embodiments, the gene editing reaction comprises clustered regularly interspaced short palindromic repeats (CRISPR)-based gene editing.", "In some embodiments, at least one of the first individual barcode molecule and the second individual barcode molecule is coupled to a bead, such as a gel bead.", "The bead can be degradable.", "In some embodiments, the method further comprises, after (a), releasing the first individual barcode molecule or the second individual barcode from the bead.", "In some embodiments, the given partition further comprises an agent capable of releasing the first individual barcode molecule or the second individual barcode from the bead.", "In some embodiments, the given partition selected is a droplet among a plurality of droplets or a well among a plurality of wells.", "In some embodiments, the first nucleic acid barcode sequence and the second nucleic barcode sequence are identical.", "In some embodiments, the method further comprises performing one or more reactions subsequent to removing the first nucleic acid molecule and the second nucleic acid molecule from the given partition.", "Another aspect of the disclosure provides a composition for characterizing a plurality of analytes.", "The composition comprises a partition comprising a plurality of barcode molecules and the plurality of analytes.", "The plurality of barcode molecules can comprise at least 1,000 barcode molecules.", "In addition, (i) a first individual barcode molecule of the plurality of barcode molecules can comprise a first nucleic acid barcode sequence that is capable of coupling to a first analyte of the plurality of analytes; and (ii) a second individual barcode molecule of the plurality of barcoded molecules can comprise a second nucleic acid barcode sequence that is capable of coupling to a second analyte of the plurality of analytes, where the first analyte and the second analyte are different types of analytes.", "In some embodiments, the first analyte is a nucleic acid molecule, such as genomic deoxyribonucleic acid (gDNA) or is messenger RNA (mRNA).", "In some embodiments, the first analyte is a labelling agent capable of coupling to a cell surface feature of a cell.", "In some embodiments, the first individual barcode molecule or the second individual barcode molecule is capable of coupling to the labelling agent via a third nucleic acid molecule coupled to the labelling agent.", "In some embodiments, the cell surface feature is a receptor, an antigen, or a protein.", "In some embodiments, the labelling agent is an antibody, an antibody fragment, an antibody fragment, or a major histocompatibility complex (MHC).", "In some embodiments, the partition comprises the cell or one or more components of the cell.", "In some embodiments, the partition comprises a single cell.", "In some embodiments, the first nucleic acid molecule or the second nucleic molecule comprises a third barcode sequence.", "In some embodiments, the third barcode sequence is derived from a third nucleic acid molecule.", "In some embodiments, the third nucleic acid molecule is coupled to a labelling agent capable of binding to a cell surface feature of a cell.", "In some embodiments, the first analyte and second analyte are different types nucleic acid molecules.", "In some embodiments, the first analyte is a ribonucleic acid molecule and the second analyte is a deoxyribonucleic acid molecule.", "In some embodiments, (i) the first individual barcode molecule comprises a first priming sequence capable of hybridizing to the first analyte; or (ii) the second individual barcode molecule comprises a second priming sequence capable of hybridizing to the second analyte.", "In some embodiments, the first barcode molecule or the second barcode molecule comprises a unique molecular identification (UMI) sequence.", "In some embodiments, the first analyte is a nucleic acid molecule and the second analyte is a labelling agent capable of coupling to a cell surface feature.", "In some embodiments, the first analyte is a ribonucleic acid molecule.", "In some embodiments, (i) the first individual barcode molecule comprises a first priming sequence capable of hybridizing to the first analyte; or (ii) the second individual barcode molecule comprises a second priming sequence capable of hybridizing to a third nucleic acid molecule coupled to the labelling agent.", "In some embodiments, the labelling agent is an antibody, an antibody fragment, or a major histocompatibility complex (MHC).", "In some embodiments, the cell surface feature is a receptor, an antigen, or a protein.", "In some embodiments, the first analyte comprises a nucleic acid molecule with a nucleic acid sequence or complement thereof that encodes at least a portion of a V(D)J sequence of an immune cell receptor.", "In some embodiments, the nucleic acid sequence is a ribonucleic acid molecule.", "In some embodiments, the nucleic acid molecule comprises a nucleic acid sequence that is complementary DNA (cDNA) derived from reverse transcription of an mRNA encoding the at least a portion of the V(D)J sequence.", "In some embodiments, the first analyte comprises a nucleic acid molecule with a nucleic acid sequence that is capable of functioning as a component of a gene editing reaction.", "In some embodiments, the gene editing reaction comprises clustered regularly interspaced short palindromic repeats (CRISPR)-based gene editing.", "In some embodiments, at least one of the first individual barcode molecule and the second individual barcode molecule is coupled to a bead, such as a gel bead.", "The bead may be degradable.", "In some embodiments, the given partition further comprises an agent capable of releasing the first individual barcode molecule or the second individual barcode from the bead.", "In some embodiments, the given partition is a droplet among a plurality of droplets or a well among a plurality of wells.", "In some embodiments, the first nucleic acid barcode sequence and the second nucleic barcode sequence are identical.", "An additional aspect of the disclosure provides a system for characterizing a plurality of analytes.", "The system comprises a partitioning unit for providing a partition comprising a plurality of barcode molecules and the plurality of analytes, where: (i) a first individual barcode molecule of the plurality of barcode molecules comprises a first nucleic acid barcode sequence and is capable of coupling to a first analyte of the plurality of analytes; and (ii) a second individual barcode molecule of the plurality of barcode molecules comprises a second nucleic acid barcode sequence and is capable of coupling to a second analyte of the plurality of analytes, where the first analyte and the second analyte are different types of analytes.", "The system also includes a controller coupled to the partitioning unit, where the controller is programmed to (i) direct the partitioning unit to provide the partition; (ii) subject the partition to conditions that are sufficient to: (1) synthesize a first nucleic acid molecule comprising at least a portion of the first nucleic acid barcode sequence or complement thereof; and (2) synthesize a second nucleic acid molecule comprising at least a portion of the second nucleic acid barcode sequence or complement thereof, where sequencing of the first nucleic acid molecule and the second nucleic acid molecule, or derivatives thereof, characterizes the first analyte or the second analyte.", "In some embodiments, the partitioning unit comprises a plurality of channels.", "In some embodiments, the partitioning unit further comprises at least one channel junction, where the at least one channel junction is configured to provide the partition.", "In some embodiments, the system also includes (i) a first channel fluidically connected to the at least one channel junction and configured to provide a first fluid to the at least one channel junction; (ii) and a second channel fluidically connected to the at least one channel junction and configured to provide a second fluid, immiscible with the first fluid, to the at least one channel junction.", "In some embodiments, the first analyte is a nucleic acid molecule, such as genomic deoxyribonucleic acid (gDNA) or messenger RNA (mRNA).", "In some embodiments, the first analyte is a labelling agent capable of coupling to a cell surface feature of a cell.", "In some embodiments, the first individual barcode molecule or the second individual barcode molecule is capable of coupling to the labelling agent via a third nucleic acid molecule coupled to the labelling agent.", "In some embodiments, the cell surface feature is a receptor, an antigen, or a protein.", "In some embodiments, the labelling agent is an antibody, an antibody fragment, or a major histocompatibility complex (MHC).", "In some embodiments, the partition comprises the cell or one or more components of the cell.", "In some embodiments, the partition comprises a single cell.", "In some embodiments, the first nucleic acid molecule or the second nucleic molecule comprises a third barcode sequence.", "In some embodiments, the third barcode sequence is derived from a third nucleic acid molecule.", "In some embodiments, the third nucleic acid molecule is coupled to a labelling agent capable of binding to a cell surface feature of a cell.", "In some embodiments, the first analyte and second analyte are different types nucleic acid molecules.", "In some embodiments, the first analyte is a ribonucleic acid molecule and the second analyte is a deoxyribonucleic acid molecule.", "In some embodiments, (i) the first individual barcode molecule comprises a first priming sequence capable of hybridizing to the first analyte; or (ii) the second individual barcode molecule comprises a second priming sequence capable of hybridizing to the second analyte.", "In some embodiments, the first barcode molecule or the second barcode molecule comprises a unique molecular identification (UMI) sequence.", "In some embodiments, the first analyte is a nucleic acid molecule and the second analyte is a labelling agent capable of coupling to a cell surface feature.", "In some embodiments, the first analyte is a ribonucleic acid molecule.", "In some embodiments, (i) the first individual barcode molecule comprises a first priming sequence capable of hybridizing to the first analyte; or (ii) the second individual barcode molecule comprises a second priming sequence capable of hybridizing to a third nucleic acid molecule coupled to the labelling agent.", "In some embodiments, the labelling agent is an antibody, an antibody fragment, or a major histocompatibility complex (MHC).", "In some embodiments, the cell surface feature is a receptor, an antigen, or a protein.", "In some embodiments, the first analyte comprises a nucleic acid molecule with a nucleic acid sequence or complement thereof that encodes at least a portion of a V(D)J sequence of an immune cell receptor.", "In some embodiments, the nucleic acid sequence is a messenger ribonucleic acid molecule.", "In some embodiments, the nucleic acid molecule is complementary DNA (cDNA) derived from reverse transcription of an mRNA encoding the at least a portion of the V(D)J sequence.", "In some embodiments, the first analyte comprises a nucleic acid molecule with a nucleic acid sequence that is capable of functioning as a component of a gene editing reaction.", "In some embodiments, the gene editing reaction comprises clustered regularly interspaced short palindromic repeats (CRISPR)-based gene editing.", "In some embodiments, at least one of the first individual barcode molecule and the second individual barcode molecule is coupled to a bead, such as a gel bead.", "The bead may be degradable.", "In some embodiments, the partition further comprises an agent capable of releasing the first individual barcode molecule or the second individual barcode from the bead.", "In some embodiments, the partition is a droplet among a plurality of droplets or a well among a plurality of wells.", "In some embodiments, the nucleic acid barcode sequence and the second nucleic barcode sequence are identical.", "In some embodiments, the partition comprises at least 1,000 barcode molecules.", "Additional aspects and advantages of the present disclosure will become readily apparent to those skilled in this art from the following detailed description, wherein only illustrative embodiments of the present disclosure are shown and described.", "As will be realized, the present disclosure is capable of other and different embodiments, and its several details are capable of modifications in various obvious respects, all without departing from the disclosure.", "Accordingly, the drawings and description are to be regarded as illustrative in nature, and not as restrictive.", "INCORPORATION BY REFERENCE All publications, patents, and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication, patent, or patent application was specifically and individually indicated to be incorporated by reference.", "BRIEF DESCRIPTION OF THE DRAWINGS The novel features of the invention are set forth with particularity in the appended claims.", "A better understanding of the features and advantages of the present invention will be obtained by reference to the following detailed description that sets forth illustrative embodiments, in which the principles of the invention are utilized, and the accompanying drawings (also “Figure” and “FIG.” herein), of which: FIG.", "1 schematically illustrates a microfluidic channel structure for partitioning individual or small groups of cells; FIG.", "2 schematically illustrates a microfluidic channel structure for co-partitioning cells and microcapsules (e.g., beads) comprising additional reagents; FIGS.", "3A-3F schematically illustrate an example process for amplification and barcoding of cell's nucleic acids; FIG.", "4 provides a schematic illustration of use of barcoding of cell's nucleic acids in attributing sequence data to individual cells or groups of cells for use in their characterization; FIG.", "5 provides a schematic illustration of cells associated with labeled cell-binding ligands; FIG.", "6 provides a schematic illustration of an example workflow for performing RNA analysis using the methods described herein; FIG.", "7 provides a schematic illustration of an example barcoded oligonucleotide structure for use in analysis of ribonucleic (RNA) using the methods described herein; FIG.", "8 provides an image of individual cells co-partitioned along with individual barcode bearing beads; FIGS.", "9A-9E provide schematic illustrations of example barcoded oligonucleotide structures for use in analysis of RNA and example operations for performing RNA analysis (“AAAAAAAAAAAAAAAA” disclosed as SEQ ID NO: 1); FIG.", "10 provides a schematic illustration of example barcoded oligonucleotide structure for use in example analysis of RNA and use of a sequence for in vitro transcription (“AAAAAAAAAAAAAAAA” disclosed as SEQ ID NO: 1); FIG.", "11 provides a schematic illustration of an example barcoded oligonucleotide structure for use in analysis of RNA and example operations for performing RNA analysis (SEQ ID NOS: 2-3 and 2-3, respectively, in order of appearance); FIGS.", "12A-12B provide schematic illustrations of example barcoded oligonucleotide structure for use in analysis of RNA; FIGS.", "13A-13C provide illustrations of example yields from template switch reverse transcription and PCR in partitions; FIGS.", "14A-14B provide illustrations of example yields from reverse transcription and cDNA amplification in partitions with various cell numbers; FIG.", "15 provides an illustration of example yields from cDNA synthesis and real-time quantitative PCR at various input cell concentrations and also the effect of varying primer concentration on yield at a fixed cell input concentration; FIG.", "16 provides an illustration of example yields from in vitro transcription; FIG.", "17 shows an example computer control system that is programmed or otherwise configured to implement methods provided herein; FIG.", "18 provides a schematic illustration of an example barcoded oligonucleotide structure; FIG.", "19 shows example operations for performing RNA analysis; (SEQ ID NOS: 2-3, 2-3, 3, 3, and 3, respectively, in order of appearance); FIG.", "20 shows a method for characterizing a cell, according to embodiments; FIG.", "21 shows an oligonucleotide with modifications that may prevent extension by a polymerase; FIG.", "22 shows oligonucleotides comprising a U-excising element; FIG.", "23A shows a bead coupled with an oligonucleotide comprising a target-specific primer and oligonucleotides with poly-T primers (SEQ ID NOS: 4-5 and 4, respectively, in order of appearance); FIG.", "23B shows a bead coupled with a plurality of oligonucleotides, each of which comprises a target-specific primer (SEQ ID NOS: 5, 5, 5, and 5, respectively, in order of appearance); FIG.", "23C shows a bead coupled with a plurality of oligonucleotides, each of which comprises a target-specific primer and a plurality of oligonucleotides, each of which comprises a poly-T primer (SEQ ID NOS: 4-5 and 4, respectively, in order of appearance); FIG.", "24 shows a bead coupled with a plurality of oligonucleotides, each of which comprises a target-specific primer and a plurality of oligonucleotides, each of which comprises a random N-mer primer for total RNA (SEQ ID NOS: 6-7, 7, 7, 7, and 6, respectively, in order of appearance); FIG.", "25 shows oligonucleotides comprising adapters and assay primers (SEQ ID NOS: 8-9, respectively, in order of appearance); FIG.", "26 shows an oligonucleotide with an adapter comprising a switch oligo (SEQ ID NO: 10); FIG.", "27A shows oligonucleotides with backbones comprising P7 and R2 sequences and poly-T primers (SEQ ID NOS: 11, 41, 12, 42, 13, 43, 14, 44, and 11, respectively, in order of appearance).", "FIG.", "27B shows oligonucleotides with backbones comprising R1 sequences and poly-T primers (SEQ ID NOS: 15, 45, 16, 46, 17, 47, 4, 48, and 4, respectively, in order of appearance).", "FIG.", "27C shows oligonucleotides with P5, R1, and R2 sequences and poly-T primers (SEQ ID NOS: 18, 49, 18-19, 50, and 19, respectively, in order of appearance).", "FIG.", "27D shows oligonucleotides with R1 sequences and random N-mer primers (SEQ ID NOS: 20, 51, 21, 51, 22, 51, 6, 51, and 6, respectively, in order of appearance).", "FIG.", "28 shows a workflow for conjugating a DNA barcode on an antibody using an antibody-binding protein; FIG.", "29 demonstrates swelling conditions and de-swelling conditions in the process of making gel beads with magnetic particles; FIG.", "30 shows a unit cell comprising a scaffold and liquid immediately surrounding the scaffold; FIG.", "31 shows a microcapsule with a barcoded magnetic particle entrapped; FIG.", "32 shows a method for parallel sequencing DNA molecules and RNA molecules in a cell; FIG.", "33 shows various approaches for making antibody-reporter oligonucleotide conjugates; FIG.", "34 shows an antibody-reporter oligonucleotide conjugation; FIGS.", "35A-35C show a method for analyzing mRNA molecules and proteins from a single cell (“AAAAAAAAAAAAAAAAAAAAA” disclosed as SEQ ID NO: 23); FIG.", "36A shows a relationship between a diameter of a gel bead and a regent inside the gel bead; FIG.", "36B shows the relationship between the diameter of a gel bead and the number of droplets with more than one cell; FIG.", "37 shows analysis results of the CD3 protein-single-stranded DNA (ssDNA) conjugate; FIG.", "38 shows the fluorescence signals from the cells bound by labeled antibodies; FIG.", "39A shows an approach for conjugating an oligonucleotide with an antibody; FIG.", "39B shows analysis results of barcoded antibodies; FIG.", "40 shows a conjugate of a functionalized antibody-binding protein and a functionalized oligonucleotide; FIG.", "41 shows a relationship between a degree of dibenzocyclooctyne (DBCO) incorporation and input dibenzocyclooctyne-N-hydroxysuccinimidyl ester (DBCO-NHS) concentrations; FIG.", "42 shows an example relationship between the degree of conjugation and oligonucleotide equivalence; FIG.", "43 shows fluorescence signals of labeled cells measured by flow cytometry; FIG.", "44 shows a method for producing a bead coupled with oligonucleotides with different primer sequences (SEQ ID NOS: 24-26, 25-28, 15, 45, 29, and 45, respectively, in order of appearance); FIG.", "45A shows a bead coupled with a plurality of oligonucleotides (SEQ ID NOS: 30, 30, 30-31, 30, 30, 30, 30, 30, 30, 30-31, 30, and 30, respectively, in order of appearance).", "FIG.", "45B shows results from gel electrophoresis analysis of beads.", "On the beads, 0%, 5%, 15%, or 25% of coupled oligonucleotides contain antibody target primers; FIGS.", "46A-46C schematically depict components of example multi-assay schemes described herein; FIG.", "47 depicts data obtained from an example experiment described in Example XI; FIG.", "48 depicts data obtained from an example experiment described in Example XI; FIGS.", "49A and 49B depict data obtained from an example experiment described in Example XI; FIG.", "50A schematically depicts an example bead comprising oligonucleotides having two different functional sequences (SEQ ID NOS: 24 and 32, respectively, in order of appearance); FIGS.", "50B and 50C schematically depict example sequences that can be coupled to a bead (SEQ ID NOS: 33, 52, 34, 53, 35, 54, 36, 55, 37, 56, 37, 56, 37, 56, 37, and 56, respectively, in order of appearance); FIG.", "51A depicts sequences (SEQ ID NOS: 38 and 39, respectively, in order of appearance) used in an example experiment described in Example XII; FIG.", "51B graphically depicts data from an example experiment described in Example XII; FIG.", "52A depicts data obtained from an example experiment described in Example XIII; FIG.", "52B provides schematically depicts example extension schemes to link barcodes; FIGS.", "53A and 53B provide data obtained from an example experiment described in Example XIII; FIGS.", "54 and 55 provide data obtained from example experiments described in Example XIV; and FIGS.", "56A-C schematically depict an example barcoding scheme that includes major histocompatibility complexes.", "DETAILED DESCRIPTION While various embodiments of the invention have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only.", "Numerous variations, changes, and substitutions may occur to those skilled in the art without departing from the invention.", "It should be understood that various alternatives to the embodiments of the invention described herein may be employed.", "Where values are described as ranges, it will be understood that such disclosure includes the disclosure of all possible sub-ranges within such ranges, as well as specific numerical values that fall within such ranges irrespective of whether a specific numerical value or specific sub-range is expressly stated.", "The term “barcode,” as used herein, generally refers to a label, or identifier, that can be part of an analyte to convey information about the analyte.", "A barcode can be a tag attached to an analyte (e.g., nucleic acid molecule) or a combination of the tag in addition to an endogenous characteristic of the analyte (e.g., size of the analyte or end sequence(s)).", "The barcode may be unique.", "Barcodes can have a variety of different formats, for example, barcodes can include: polynucleotide barcodes; random nucleic acid and/or amino acid sequences; and synthetic nucleic acid and/or amino acid sequences.", "A barcode can be attached to an analyte in a reversible or irreversible manner.", "A barcode can be added to, for example, a fragment of a deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) sample before, during, and/or after sequencing of the sample.", "Barcodes can allow for identification and/or quantification of individual sequencing-reads in real time.", "The term “subject,” as used herein, generally refers to an animal, such as a mammalian species (e.g., human) or avian (e.g., bird) species, or other organism, such as a plant.", "The subject can be a vertebrate, a mammal, a mouse, a primate, a simian or a human.", "Animals may include, but are not limited to, farm animals, sport animals, and pets.", "A subject can be a healthy individual, an individual that has or is suspected of having a disease or a pre-disposition to the disease, or an individual that is in need of therapy or suspected of needing therapy.", "A subject can be a patient.", "The term “genome,” as used herein, generally refers to an entirety of a subject's hereditary information.", "A genome can be encoded either in DNA or in RNA.", "A genome can comprise coding regions that code for proteins as well as non-coding regions.", "A genome can include the sequence of all chromosomes together in an organism.", "For example, the human genome has a total of 46 chromosomes.", "The sequence of all of these together may constitute a human genome.", "The terms “adaptor(s)”, “adapter(s)” and “tag(s)” may be used synonymously.", "An adaptor or tag can be coupled to a polynucleotide sequence to be “tagged” by any approach including ligation, hybridization, or other approaches.", "The term “sequencing,” as used herein, generally refers to methods and technologies for determining the sequence of nucleotide bases in one or more polynucleotides.", "The polynucleotides can be, for example, deoxyribonucleic acid (DNA) or ribonucleic acid (RNA), including variants or derivatives thereof (e.g., single stranded DNA).", "Sequencing can be performed by various systems currently available, such as, without limitation, a sequencing system by Illumina, Pacific Biosciences, Oxford Nanopore, or Life Technologies (Ion Torrent).", "Such devices may provide a plurality of raw genetic data corresponding to the genetic information of a subject (e.g., human), as generated by the device from a sample provided by the subject.", "In some situations, systems and methods provided herein may be used with proteomic information.", "The term “variant,” as used herein, generally refers to a genetic variant, such as a nucleic acid molecule comprising a polymorphism.", "A variant can be a structural variant or copy number variant, which can be genomic variants that are larger than single nucleotide variants or short indels.", "A variant can be an alteration or polymorphism in a nucleic acid sample or genome of a subject.", "Single nucleotide polymorphisms (SNPs) are a form of polymorphisms.", "Polymorphisms can include single nucleotide variations (SNVs), insertions, deletions, repeats, small insertions, small deletions, small repeats, structural variant junctions, variable length tandem repeats, and/or flanking sequences.", "Copy number variants (CNVs), transversions and other rearrangements are also forms of genetic variation.", "A genomic alteration may be a base change, insertion, deletion, repeat, copy number variation, or transversion.", "The term “bead,” as used herein, generally refers to a particle.", "The bead may be a solid or semi-solid particle.", "The bead may be a gel.", "The bead may be formed of a polymeric material.", "The bead may be magnetic or non-magnetic.", "The term “sample,” as used herein, generally refers to a biological sample of a subject.", "The sample may be a tissue sample, such as a biopsy, core biopsy, needle aspirate, or fine needle aspirate.", "The sample may be a fluid sample, such as a blood sample, urine sample, or saliva sample.", "The sample may be a skin sample.", "The sample may be a cheek swab.", "The sample may be a plasma or serum sample.", "The sample may be a cell-free (or cell free) sample.", "A cell-free sample may include extracellular polynucleotides.", "Extracellular polynucleotides may be isolated from a bodily sample that may be selected from a group consisting of blood, plasma, serum, urine, saliva, mucosal excretions, sputum, stool and tears.", "The term “nucleic acid,” as used herein, generally refers to a monomeric or polymeric form of nucleotides of any length, either deoxyribonucleotides or ribonucleotides, or analogs or variants thereof.", "A nucleic acid molecule may include one or more unmodified or modified nucleotides.", "Nucleic acid may have any three dimensional structure, and may perform any function.", "The following are non-limiting examples of nucleic acids: ribonucleic acid (RNA), deoxyribonucleic acid (DNA), coding or non-coding regions of a gene or gene fragment, loci (locus) defined from linkage analysis, exons, introns, messenger RNA (mRNA), transfer ribonucleic acid (RNA), ribosomal RNA, short interfering RNA (siRNA), short-hairpin RNA (shRNA), micro-RNA (miRNA), ribozymes, complementary deoxyribonucleic acid (cDNA), recombinant polynucleotides, branched polynucleotides, plasmids, vectors, isolated DNA of any sequence, isolated RNA of any sequence, nucleic acid probes, and primers.", "Nucleic acid may comprise one or more modified nucleotides, such as methylated nucleotides and nucleotide analogs, such as peptide nucleic acid (PNA), Morpholino and locked nucleic acid (LNA), glycol nucleic acid (GNA), threose nucleic acid (TNA), 2′-fluoro, 2′-OMe, and phosphorothiolated DNA.", "A nucleic acid may include one or more subunits selected from adenosine (A), cytosine (C), guanine (G), thymine (T) and uracil (U), or variants thereof.", "In some examples, a nucleic acid is DNA or RNA, or derivatives thereof.", "A nucleic acid may be single-stranded or double stranded.", "A nucleic acid may be circular.", "The term “nucleotide,” as used herein, generally refers to a nucleic acid subunit, which may include A, C, G, T or U, or variants or analogs thereof.", "A nucleotide can include any subunit that can be incorporated into a growing nucleic acid strand.", "Such subunit can be an A, C, G, T, or U, or any other subunit that is specific to one or more complementary A, C, G, T or U, or complementary to a purine (i.e., A or G, or variant or analogs thereof) or a pyrimidine (i.e., C, T or U, or variant or analogs thereof).", "A subunit can enable individual nucleic acid bases or groups of bases (e.g., AA, TA, AT, GC, CG, CT, TC, GT, TG, AC, CA, or uracil-counterparts thereof) to be resolved.", "The term “analyte,” as used herein, generally refers to a substance or one or more constituents thereof that is for identification, such as detection (e.g., detection via sequencing).", "Examples of analytes include, without limitation, DNA, RNA, a labelling agent, antibody, and protein.", "An analyte may be a cell or one or more constituents of a cell.", "Analytes may be of different types.", "In some examples, in a plurality of analytes, a given analyte is of a different structural or functional class from other analytes of the plurality.", "Examples of different types of analytes include DNA and RNA; a nucleic acid molecule and a labelling agent; a transcript and genomic nucleic acid; a plurality of nucleic acid molecules, where each nucleic acid molecule has a different function, such as a different cellular function.", "A sample may have a plurality of analytes of different types, such as a mixture of DNA and RNA molecules, or a mixture of nucleic acid molecules and labelling agents.", "In some cases, different types of analytes do not include labelling agents directed to separate cell surface features of a cell.", "Nucleic acid sequencing technologies have yielded substantial results in sequencing biological materials, including providing substantial sequence information on individual organisms, and relatively pure biological samples.", "However, these systems have traditionally not been effective at being able to identify and characterize cells at the single cell level.", "Nucleic acid sequencing technologies may derive the nucleic acids that they sequence from collections of cells obtained from tissue or other samples, such as biological fluids (e.g., blood, plasma, etc).", "The cells can be processed (e.g., all together in an ensemble approach) to extract the genetic material that represents an average of the population of cells, which can then be processed into sequencing ready DNA libraries that are configured for a given sequencing technology.", "Although often discussed in terms of DNA or nucleic acids, the nucleic acids derived from the cells may include DNA, or RNA, including, e.g., mRNA, total RNA, or the like, that may be processed to produce cDNA for sequencing.", "In addition to the inability to attribute characteristics to particular subsets of cells or individual cells, such ensemble sample preparation methods can be, from the outset, predisposed to primarily identifying and characterizing the majority constituents in the sample of cells, and may not be designed to pick out the minority constituents, e.g., genetic or proteomic material contributed by one cell, a few cells, or a small percentage of total cells in the sample.", "Likewise, where analyzing expression levels, e.g., of mRNA or cell surface proteins, an ensemble approach can be predisposed to presenting potentially inaccurate data from cell populations that are non-homogeneous in terms of expression levels.", "In some cases, where expression is high in a small minority of the cells in an analyzed population, and absent in the majority of the cells of the population, an ensemble method may indicate low level expression for the entire population.", "These inaccuracies can be further magnified through processing operations used in generating the sequencing libraries from these samples.", "Some next generation sequencing technologies (e.g., massively parallel sequencing) may rely upon the geometric amplification of nucleic acid fragments, such as via polymerase chain reaction, in order to produce sufficient DNA for the sequencing library.", "However, such amplification can be biased toward amplification of majority constituents in a sample, and may not preserve the starting ratios of such minority and majority components.", "While some of these difficulties may be addressed by utilizing different sequencing systems, such as single molecule systems that do not require amplification, the single molecule systems, as well as the ensemble sequencing methods of other next generation sequencing (NGS) systems, can also have large input DNA requirements.", "Some single molecule sequencing systems, for example, can have sample input DNA requirements of from 500 nanograms (ng) to upwards of 10 micrograms (μg), which may not be obtainable from individual cells or small subpopulations of cells.", "Likewise, other NGS systems can be optimized for starting amounts of sample DNA in the sample of from approximately 50 nanograms (ng) to about 1 microgram (μg).", "Starting amounts of DNA may be at least about 1 ng, 10 ng, 20 ng, 30 ng, 40 ng, 50 ng, 100 ng, 500 ng, 1 μg, 10 μg, or 100 μg.", "Disclosed herein are methods and systems for characterizing surface features, proteins, and nucleic acids of small populations of cells, and in some cases, for characterizing surface features, proteins, and nucleic acids of individual cells.", "The methods described herein may compartmentalize the analysis of individual cells or small populations of cells, including e.g., cell surface features, proteins, and nucleic acids of individual cells or small groups of cells, and then allow that analysis to be attributed back to the individual cell or small group of cells from which the cell surface features, proteins, and nucleic acids were derived.", "This can be accomplished regardless of whether the cell population represents a 50/50 mix of cell types, a 90/10 mix of cell types, or virtually any ratio of cell types, as well as a complete heterogeneous mix of different cell types, or any mixture between these.", "Differing cell types may include cells from different tissue types of an individual or the same tissue type from different individuals, or biological organisms such as microorganisms from differing genera, species, strains, variants, or any combination of any or all of the foregoing.", "For example, differing cell types may include normal and tumor tissue from an individual, various cell types obtained from a human subject such as a variety of immune cells (e.g., B cells, T cells, and the like), multiple different bacterial species, strains and/or variants from environmental, forensic, microbiome or other samples, or any of a variety of other mixtures of cell types.", "In one aspect, the methods and systems described herein provide for the compartmentalization, depositing or partitioning of the nucleic acid contents of individual cells from a sample material containing cells, into discrete compartments or partitions (referred to interchangeably herein as partitions), where each partition maintains separation of its own contents from the contents of other partitions.", "In another aspect, the methods and system described herein provide for the compartmentalization, depositing or partitioning of individual cells from a sample material containing cells, into discrete partitions, where each partition maintains separation of its own contents from the contents of other partitions.", "In another aspect, the methods and system described herein provide for the compartmentalization, depositing or partitioning of individual cells from a sample material containing cells after at least one labelling agent has been bound to a cell surface feature of the cell, into discrete partitions, where each partition maintains separation of its own contents from the contents of other partitions.", "Unique identifiers, e.g., barcodes, may be previously, subsequently or concurrently delivered to the partitions that hold the compartmentalized or partitioned cells, in order to allow for the later attribution of the characteristics of the individual cells to the particular compartment.", "Further, unique identifiers, e.g., barcodes, may be coupled to labelling agents and previously, subsequently or concurrently delivered to the partitions that hold the compartmentalized or partitioned cells, in order to allow for the later attribution of the characteristics of the individual cells to the particular compartment.", "Barcodes may be delivered, for example on an oligonucleotide, to a partition via any suitable mechanism.", "In some embodiments, barcoded oligonucleotides are delivered to a partition via a microcapsule.", "In some cases, barcoded oligonucleotides are initially associated with the microcapsule and then released from the microcapsule upon application of a stimulus which allows the oligonucleotides to dissociate or to be released from the microcapsule.", "In some embodiments, anchor oligonucleotides are delivered to a partition via a microcapsule.", "In some cases, anchor oligonucleotides are initially associated with the microcapsule and then released from the microcapsule upon application of a stimulus which allows the anchor oligonucleotides to dissociate or to be released from the microcapsule.", "A microcapsule may be or may include a solid support or solid particle such as a bead.", "A solid support or a solid particle may be a bead.", "A microcapsule may be a droplet.", "A microcapsule, in some embodiments, may be or may comprise a bead.", "In some embodiments, a bead may be porous, non-porous, solid, semi-solid, semi-fluidic, or fluidic.", "In some embodiments, a bead may be dissolvable, disruptable, or degradable.", "In some cases, a bead may not be degradable.", "In some embodiments, the bead may be a gel bead.", "A gel bead may be a hydrogel bead.", "A gel bead may be formed from molecular precursors, such as a polymeric or monomeric species.", "A semi-solid bead may be a liposomal bead.", "Solid beads may comprise metals including iron oxide, gold, and silver.", "In some cases, the beads may be silica beads.", "In some cases, the beads may be rigid.", "In some cases, the beads may be flexible and/or compressible.", "In some embodiments, the bead may contain molecular precursors (e.g., monomers or polymers), which may form a polymer network via polymerization of the precursors.", "In some cases, a precursor may be an already polymerized species capable of undergoing further polymerization via, for example, a chemical cross-linkage.", "In some cases, a precursor comprises one or more of an acrylamide or a methacrylamide monomer, oligomer, or polymer.", "In some cases, the bead may comprise prepolymers, which are oligomers capable of further polymerization.", "For example, polyurethane beads may be prepared using prepolymers.", "In some cases, the bead may contain individual polymers that may be further polymerized together.", "In some cases, beads may be generated via polymerization of different precursors, such that they comprise mixed polymers, co-polymers, and/or block co-polymers.", "A bead may comprise natural and/or synthetic materials.", "For example, a polymer can be a natural polymer or a synthetic polymer.", "In some cases, a bead may comprise both natural and synthetic polymers.", "Examples of natural polymers include proteins and sugars such as deoxyribonucleic acid, rubber, cellulose, starch (e.g., amylose, amylopectin), proteins, enzymes, polysaccharides, silks, polyhydroxyalkanoates, chitosan, dextran, collagen, carrageenan, ispaghula, acacia, agar, gelatin, shellac, sterculia gum, xanthan gum, Corn sugar gum, guar gum, gum karaya, agarose, alginic acid, alginate, or natural polymers thereof.", "Examples of synthetic polymers include acrylics, nylons, silicones, spandex, viscose rayon, polycarboxylic acids, polyvinyl acetate, polyacrylamide, polyacrylate, polyethylene glycol, polyurethanes, polylactic acid, silica, polystyrene, polyacrylonitrile, polybutadiene, polycarbonate, polyethylene, polyethylene terephthalate, poly(chlorotrifluoroethylene), poly(ethylene oxide), poly(ethylene terephthalate), polyethylene, polyisobutylene, poly(methyl methacrylate), poly(oxymethylene), polyformaldehyde, polypropylene, polystyrene, poly(tetrafluoroethylene), poly(vinyl acetate), poly(vinyl alcohol), poly(vinyl chloride), poly(vinylidene dichloride), poly(vinylidene difluoride), poly(vinyl fluoride) and combinations (e.g., co-polymers) thereof.", "Beads may also be formed from materials other than polymers, including lipids, micelles, ceramics, glass-ceramics, material composites, metals, other inorganic materials, and others.", "In some cases, a chemical cross-linker may be a precursor used to cross-link monomers during polymerization of the monomers and/or may be used to attach oligonucleotides (e.g., barcoded oligonucleotides) to the bead.", "In some cases, polymers may be further polymerized with a cross-linker species or other type of monomer to generate a further polymeric network.", "Non-limiting examples of chemical cross-linkers (also referred to as a “crosslinker” or a “crosslinker agent” herein) include cystamine, gluteraldehyde, dimethyl suberimidate, N-Hydroxysuccinimide crosslinker BS3, formaldehyde, carbodiimide (EDC), SMCC, Sulfo-SMCC, vinylsilane, N,N′diallyltartardiamide (DATD), N,N′-Bis(acryloyl)cystamine (BAC), or homologs thereof.", "In some cases, the crosslinker used in the present disclosure contains cystamine.", "Crosslinking may be permanent or reversible, depending upon the particular crosslinker used.", "Reversible crosslinking may allow for the polymer to linearize or dissociate under appropriate conditions.", "In some cases, reversible cross-linking may also allow for reversible attachment of a material bound to the surface of a bead.", "In some cases, a cross-linker may form disulfide linkages.", "In some cases, the chemical cross-linker forming disulfide linkages may be cystamine or a modified cystamine.", "In some embodiments, disulfide linkages can be formed between molecular precursor units (e.g., monomers, oligomers, or linear polymers) or precursors incorporated into a bead and oligonucleotides.", "Cystamine (including modified cystamines), for example, is an organic agent comprising a disulfide bond that may be used as a crosslinker agent between individual monomeric or polymeric precursors of a bead.", "Polyacrylamide may be polymerized in the presence of cystamine or a species comprising cystamine (e.g., a modified cystamine) to generate polyacrylamide gel beads comprising disulfide linkages (e.g., chemically degradable beads comprising chemically-reducible cross-linkers).", "The disulfide linkages may permit the bead to be degraded (or dissolved) upon exposure of the bead to a reducing agent.", "In some embodiments, chitosan, a linear polysaccharide polymer, may be crosslinked with glutaraldehyde via hydrophilic chains to form a bead.", "Crosslinking of chitosan polymers may be achieved by chemical reactions that are initiated by heat, pressure, change in pH, and/or radiation.", "In some embodiments, the bead may comprise covalent or ionic bonds between polymeric precursors (e.g., monomers, oligomers, linear polymers), oligonucleotides, primers, and other entities.", "In some cases, the covalent bonds comprise carbon-carbon bonds or thioether bonds.", "In some cases, a bead may comprise an acrydite moiety, which in certain aspects may be used to attach one or more oligonucleotides (e.g., barcode sequence, barcoded oligonucleotide, primer, or other oligonucleotide) to the bead.", "In some cases, an acrydite moiety can refer to an acrydite analogue generated from the reaction of acrydite with one or more species, such as, the reaction of acrydite with other monomers and cross-linkers during a polymerization reaction.", "Acrydite moieties may be modified to form chemical bonds with a species to be attached, such as an oligonucleotide (e.g., barcode sequence, barcoded oligonucleotide, primer, or other oligonucleotide).", "Acrydite moieties may be modified with thiol groups capable of forming a disulfide bond or may be modified with groups already comprising a disulfide bond.", "The thiol or disulfide (via disulfide exchange) may be used as an anchor point for a species to be attached or another part of the acrydite moiety may be used for attachment.", "In some cases, attachment is reversible, such that when the disulfide bond is broken (e.g., in the presence of a reducing agent), the attached species is released from the bead.", "In other cases, an acrydite moiety comprises a reactive hydroxyl group that may be used for attachment.", "Functionalization of beads for attachment of oligonucleotides may be achieved through a wide range of different approaches, including activation of chemical groups within a polymer, incorporation of active or activatable functional groups in the polymer structure, or attachment at the pre-polymer or monomer stage in bead production.", "For example, precursors (e.g., monomers, cross-linkers) that are polymerized to form a bead may comprise acrydite moieties, such that when a bead is generated, the bead also comprises acrydite moieties.", "The acrydite moieties can be attached to an oligonucleotide, such as a primer (e.g., a primer for amplifying target nucleic acids, barcoded oligonucleotide, etc) to be incorporated into the bead.", "In some cases, the primer comprises a P5 sequence for attachment to a sequencing flow cell for Illumina sequencing.", "In some cases, the primer comprises a P7 sequence for attachment to a sequencing flow cell for Illumina sequencing.", "In some cases, the primer comprises a barcode sequence.", "In some cases, the primer further comprises a unique molecular identifier (UMI).", "In some cases, the primer comprises an R1 primer sequence for Illumina sequencing.", "In some cases, the primer comprises an R2 primer sequence for Illumina sequencing.", "In some cases, precursors comprising a functional group that is reactive or capable of being activated such that it becomes reactive can be polymerized with other precursors to generate gel beads comprising the activated or activatable functional group.", "The functional group may then be used to attach additional species (e.g., disulfide linkers, primers, other oligonucleotides, etc.)", "to the gel beads.", "For example, some precursors comprising a carboxylic acid (COOH) group can co-polymerize with other precursors to form a gel bead that also comprises a COOH functional group.", "In some cases, acrylic acid (a species comprising free COOH groups), acrylamide, and bis(acryloyl)cystamine can be co-polymerized together to generate a gel bead comprising free COOH groups.", "The COOH groups of the gel bead can be activated (e.g., via 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-Hydroxysuccinimide (NHS) or 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM)) such that they are reactive (e.g., reactive to amine functional groups where EDC/NHS or DMTMM are used for activation).", "The activated COOH groups can then react with an appropriate species (e.g., a species comprising an amine functional group where the carboxylic acid groups are activated to be reactive with an amine functional group) comprising a moiety to be linked to the bead.", "Beads comprising disulfide linkages in their polymeric network may be functionalized with additional species via reduction of some of the disulfide linkages to free thiols.", "The disulfide linkages may be reduced via, for example, the action of a reducing agent (e.g., DTT, TCEP, etc.)", "to generate free thiol groups, without dissolution of the bead.", "Free thiols of the beads can then react with free thiols of a species or a species comprising another disulfide bond (e.g., via thiol-disulfide exchange) such that the species can be linked to the beads (e.g., via a generated disulfide bond).", "In some cases, free thiols of the beads may react with any other suitable group.", "For example, free thiols of the beads may react with species comprising an acrydite moiety.", "The free thiol groups of the beads can react with the acrydite via Michael addition chemistry, such that the species comprising the acrydite is linked to the bead.", "In some cases, uncontrolled reactions can be prevented by inclusion of a thiol capping agent such as N-ethylmalieamide or iodoacetate.", "Activation of disulfide linkages within a bead can be controlled such that only a small number of disulfide linkages are activated.", "Control may be exerted, for example, by controlling the concentration of a reducing agent used to generate free thiol groups and/or concentration of reagents used to form disulfide bonds in bead polymerization.", "In some cases, a low concentration (e.g., molecules of reducing agent:gel bead ratios of less than or equal about 10000, 100000, 1000000, 10000000, 100000000, 1000000000, 10000000000, or 100000000000) of reducing agent may be used for reduction.", "Controlling the number of disulfide linkages that are reduced to free thiols may be useful in ensuring bead structural integrity during functionalization.", "In some cases, optically-active agents, such as fluorescent dyes may be may be coupled to beads via free thiol groups of the beads and used to quantify the number of free thiols present in a bead and/or track a bead.", "In some cases, addition of moieties to a gel bead after gel bead formation may be advantageous.", "For example, addition of an oligonucleotide (e.g., barcoded oligonucleotide) after gel bead formation may avoid loss of the species during chain transfer termination that can occur during polymerization.", "Moreover, smaller precursors (e.g., monomers or cross linkers that do not comprise side chain groups and linked moieties) may be used for polymerization and can be minimally hindered from growing chain ends due to viscous effects.", "In some cases, functionalization after gel bead synthesis can minimize exposure of species (e.g., oligonucleotides) to be loaded with potentially damaging agents (e.g., free radicals) and/or chemical environments.", "In some cases, the generated gel may possess an upper critical solution temperature (UCST) that can permit temperature driven swelling and collapse of a bead.", "Such functionality may aid in oligonucleotide (e.g., a primer) infiltration into the bead during subsequent functionalization of the bead with the oligonucleotide.", "Post-production functionalization may also be useful in controlling loading ratios of species in beads, such that, for example, the variability in loading ratio is minimized.", "Species loading may also be performed in a batch process such that a plurality of beads can be functionalized with the species in a single batch.", "In some cases, an acrydite moiety linked to precursor, another species linked to a precursor, or a precursor itself comprises a labile bond, such as chemically, thermally, or photo-sensitive bonds e.g., disulfide bonds, UV sensitive bonds, or the like.", "Once acrydite moieties or other moieties comprising a labile bond are incorporated into a bead, the bead may also comprise the labile bond.", "The labile bond may be, for example, useful in reversibly linking (e.g., covalently linking) species (e.g., barcodes, primers, etc.)", "to a bead.", "In some cases, a thermally labile bond may include a nucleic acid hybridization based attachment, e.g., where an oligonucleotide is hybridized to a complementary sequence that is attached to the bead, such that thermal melting of the hybrid releases the oligonucleotide, e.g., a barcode containing sequence, from the bead or microcapsule.", "The addition of multiple types of labile bonds to a gel bead may result in the generation of a bead capable of responding to varied stimuli.", "Each type of labile bond may be sensitive to an associated stimulus (e.g., chemical stimulus, light, temperature, etc.)", "such that release of species attached to a bead via each labile bond may be controlled by the application of the appropriate stimulus.", "Such functionality may be useful in controlled release of species from a gel bead.", "In some cases, another species comprising a labile bond may be linked to a gel bead after gel bead formation via, for example, an activated functional group of the gel bead as described above.", "As will be appreciated, barcodes that are releasably, cleavably or reversibly attached to the beads described herein include barcodes that are released or releasable through cleavage of a linkage between the barcode molecule and the bead, or that are released through degradation of the underlying bead itself, allowing the barcodes to be accessed or accessible by other reagents, or both.", "Species (e.g., oligonucleotides comprising barcodes) attached to a solid support (e.g., a bead) may comprise a U-excising element that allows the species to release from the bead.", "In some cases, the U-excising element may comprise a single-stranded DNA (ssDNA) sequence that contains at least one uracil.", "The species may be attached to a solid support via the ssDNA sequence.", "The species may be released by a combination of uracil-DNA glycosylase (e.g., to remove the uracil) and an endonuclease (e.g., to induce an ssDNA break).", "If the endonuclease generates a 5′ phosphate group from the cleavage, then additional enzyme treatment may be included in downstream processing to eliminate the phosphate group, e.g., prior to ligation of additional sequencing handle elements, e.g., Illumina full P5 sequence, partial P5 sequence, full R1 sequence, and/or partial R1 sequence.", "The barcodes that are releasable as described herein may sometimes be referred to as being activatable, in that they are available for reaction once released.", "Thus, for example, an activatable barcode may be activated by releasing the barcode from a bead (or other suitable type of partition described herein).", "Other activatable configurations are also envisioned in the context of the described methods and systems.", "In addition to thermally cleavable bonds, disulfide bonds and UV sensitive bonds, other non-limiting examples of labile bonds that may be coupled to a precursor or bead include an ester linkage (e.g., cleavable with an acid, a base, or hydroxylamine), a vicinal diol linkage (e.g., cleavable via sodium periodate), a Diels-Alder linkage (e.g., cleavable via heat), a sulfone linkage (e.g., cleavable via a base), a silyl ether linkage (e.g., cleavable via an acid), a glycosidic linkage (e.g., cleavable via an amylase), a peptide linkage (e.g., cleavable via a protease), or a phosphodiester linkage (e.g., cleavable via a nuclease (e.g., DNAase)).", "Species that do not participate in polymerization may also be encapsulated in beads during bead generation (e.g., during polymerization of precursors).", "Such species may be entered into polymerization reaction mixtures such that generated beads comprise the species upon bead formation.", "In some cases, such species may be added to the gel beads after formation.", "Such species may include, for example, oligonucleotides (e.g.", "barcoded oligonucleotides and/or anchor oligonucleotides), reagents for a nucleic acid amplification reaction (e.g., primers, polymerases, dNTPs, co-factors (e.g., ionic co-factors)) including those described herein, reagents for enzymatic reactions (e.g., enzymes, co-factors, substrates), or reagents for a nucleic acid modification reactions such as polymerization, ligation, or digestion.", "Trapping of such species may be controlled by the polymer network density generated during polymerization of precursors, control of ionic charge within the gel bead (e.g., via ionic species linked to polymerized species), or by the release of other species.", "Encapsulated species may be released from a bead upon bead degradation and/or by application of a stimulus capable of releasing the species from the bead.", "Beads may be of uniform size or heterogeneous size.", "In some cases, the diameter of a bead may be about 1 micrometer (μm), 5 μm, 10 μm, 20 μm, 30 μm, 40 μm, 50 μm, 60 μm, 70 μm, 80 μm, 90 μm, 100 μm, 250 μm, 500 μm, or 1 mm.", "In some cases, a bead may have a diameter of at least about 1 μm, 5 μm, 10 μm, 20 μm, 30 μm, 40 μm, 50 μm, 60 μm, 70 μm, 80 μm, 90 μm, 100 μm, 250 μm, 500 μm, 1 mm, or more.", "In some cases, a bead may have a diameter of less than or equal to about 1 μm, 5 μm, 10 μm, 20 μm, 30 μm, 40 μm, 50 μm, 60 μm, 70 μm, 80 μm, 90 μm, 100 μm, 250 μm, 500 μm, or 1 mm.", "In some cases, a bead may have a diameter in the range of about 40-75 μm, 30-75 μm, 20-75 μm, 40-85 μm, 40-95 μm, 20-100 μm, 10-100 μm, 1-100 μm, 20-250 μm, or 20-500 μm.", "In certain aspects, beads are provided as a population or plurality of beads having a relatively monodisperse size distribution.", "Such monodispersity can provide relatively consistent amounts of reagents within partitions and maintain relatively consistent bead characteristics.", "In particular, the beads described herein may have size distributions that have a coefficient of variation in their cross-sectional dimensions of less than or equal to about 50%, less than or equal to about 40%, less than or equal to about 30%, less than or equal to about 20%, less than or equal to about 15%, less than or equal to about 10%, or less than or equal to about 5%.", "Beads may be of any suitable shape.", "Examples of bead shapes include, but are not limited to, spherical, non-spherical, oval, oblong, amorphous, circular, cylindrical, and variations thereof.", "In addition to, or as an alternative to the cleavable linkages between the beads and the associated molecules, e.g., barcode containing oligonucleotides, described above, the beads may be degradable, disruptable, or dissolvable spontaneously or upon exposure to one or more stimuli (e.g., temperature changes, pH changes, exposure to particular chemical species or phase, exposure to light, reducing agent, etc.).", "In some cases, a bead may be dissolvable, such that material components of the beads are solubilized when exposed to a particular chemical species or an environmental change, such as a change temperature or a change in pH.", "In some cases, a gel bead is degraded or dissolved at elevated temperature and/or in basic conditions.", "In some cases, a bead may be thermally degradable such that when the bead is exposed to an appropriate change in temperature (e.g., heat), the bead degrades.", "Degradation or dissolution of a bead bound to a species (e.g., an oligonucleotide, e.g., barcoded oligonucleotide) may result in release of the species from the bead.", "A degradable bead may comprise one or more species with a labile bond such that, when the bead/species is exposed to the appropriate stimuli, the bond is broken and the bead degrades.", "The labile bond may be a chemical bond (e.g., covalent bond, ionic bond) or may be another type of physical interaction (e.g., van der Waals interactions, dipole-dipole interactions, etc.).", "In some cases, a crosslinker used to generate a bead may comprise a labile bond.", "Upon exposure to the appropriate conditions, the labile bond can be broken and the bead degraded.", "For example, upon exposure of a polyacrylamide gel bead comprising cystamine crosslinkers to a reducing agent, the disulfide bonds of the cystamine can be broken and the bead degraded.", "A degradable bead may be useful in more quickly releasing an attached species (e.g., an oligonucleotide, a barcode sequence, a primer, etc) from the bead when the appropriate stimulus is applied to the bead as compared to a bead that does not degrade.", "For example, for a species bound to an inner surface of a porous bead or in the case of an encapsulated species, the species may have greater mobility and accessibility to other species in solution upon degradation of the bead.", "In some cases, a species may also be attached to a degradable bead via a degradable linker (e.g., disulfide linker).", "The degradable linker may respond to the same stimuli as the degradable bead or the two degradable species may respond to different stimuli.", "For example, a barcode sequence may be attached, via a disulfide bond, to a polyacrylamide bead comprising cystamine.", "Upon exposure of the barcoded-bead to a reducing agent, the bead degrades and the barcode sequence is released upon breakage of both the disulfide linkage between the barcode sequence and the bead and the disulfide linkages of the cystamine in the bead.", "A degradable bead may be introduced into a partition, such as a droplet of an emulsion or a well, such that the bead degrades within the partition and any associated species (e.g., oligonucleotides) are released within the droplet when the appropriate stimulus is applied.", "The free species (e.g., oligonucleotides) may interact with other reagents contained in the partition.", "For example, a polyacrylamide bead comprising cystamine and linked, via a disulfide bond, to a barcode sequence, may be combined with a reducing agent within a droplet of a water-in-oil emulsion.", "Within the droplet, the reducing agent may break the various disulfide bonds resulting in bead degradation and release of the barcode sequence into the aqueous, inner environment of the droplet.", "In another example, heating of a droplet comprising a bead-bound barcode sequence in basic solution may also result in bead degradation and release of the attached barcode sequence into the aqueous, inner environment of the droplet.", "As will be appreciated from the above disclosure, while referred to as degradation of a bead, degradation may refer to the disassociation of a bound or entrained species from a bead, both with and without structurally degrading the physical bead itself.", "For example, entrained species may be released from beads through osmotic pressure differences due to, for example, changing chemical environments.", "By way of example, alteration of bead pore sizes due to osmotic pressure differences can generally occur without structural degradation of the bead itself.", "In some cases, an increase in pore size due to osmotic swelling of a bead can permit the release of entrained species within the bead.", "In other cases, osmotic shrinking of a bead may cause a bead to better retain an entrained species due to pore size contraction.", "Where degradable beads are provided, it can be useful to avoid exposing such beads to the stimulus or stimuli that cause such degradation prior to a given time, in order to avoid premature bead degradation and issues that arise from such degradation, including, for example poor flow characteristics and aggregation.", "By way of example, where beads comprise reducible cross-linking groups, such as disulfide groups, it can be useful to avoid contacting such beads with reducing agents, e.g., DTT or other disulfide cleaving reagents.", "In such cases, treatment to the beads described herein will, in some cases be provided free of reducing agents, such as DTT.", "Because reducing agents are often provided in commercial enzyme preparations, reducing agent free (or DTT free) enzyme preparations may be provided in treating the beads described herein.", "Examples of such enzymes include, e.g., polymerase enzyme preparations, reverse transcriptase enzyme preparations, ligase enzyme preparations, as well as many other enzyme preparations that may be used to treat the beads described herein.", "The terms “reducing agent free” or “DTT free” preparations can refer to a preparation having less than or equal to about 1/10th, less than or equal to about 1/50th, or less than or equal to about 1/100th of the lower ranges for such materials used in degrading the beads.", "For example, for DTT, the reducing agent free preparation will typically have less than or equal to about 0.01 mM, 0.005 mM, 0.001 mM DTT, 0.0005 mM DTT, or 0.0001 mM DTT.", "In some cases, the amount of DTT will be undetectable.", "In some cases, a stimulus may be used to trigger degradation of the bead, which may result in the release of contents from the bead.", "Generally, a stimulus may cause degradation of the bead structure, such as degradation of the covalent bonds or other types of physical interaction.", "These stimuli may be useful in inducing a bead to degrade and/or to release its contents.", "Examples of stimuli that may be used include chemical stimuli, thermal stimuli, optical stimuli (e.g., light) and any combination thereof, as described more fully below.", "Numerous chemical triggers may be used to trigger the degradation of beads.", "Examples of these chemical changes may include, but are not limited to pH-mediated changes to the integrity of a component within the bead, degradation of a component of a bead via cleavage of cross-linked bonds, and depolymerization of a component of a bead.", "In some embodiments, a bead may be formed from materials that comprise degradable chemical crosslinkers, such as BAC or cystamine.", "Degradation of such degradable crosslinkers may be accomplished through a number of mechanisms.", "In some examples, a bead may be contacted with a chemical degrading agent that may induce oxidation, reduction or other chemical changes.", "For example, a chemical degrading agent may be a reducing agent, such as dithiothreitol (DTT).", "Additional examples of reducing agents may include β-mercaptoethanol, (2S)-2-amino-1,4-dimercaptobutane (dithiobutylamine or DTBA), tris(2-carboxyethyl) phosphine (TCEP), or combinations thereof.", "A reducing agent may degrade the disulfide bonds formed between gel precursors forming the bead, and thus, degrade the bead.", "In other cases, a change in pH of a solution, such as an increase in pH, may trigger degradation of a bead.", "In other cases, exposure to an aqueous solution, such as water, may trigger hydrolytic degradation, and thus degradation of the bead.", "Beads may also be induced to release their contents upon the application of a thermal stimulus.", "A change in temperature can cause a variety of changes to a bead.", "For example, heat can cause a solid bead to liquefy.", "A change in heat may cause melting of a bead such that a portion of the bead degrades.", "In other cases, heat may increase the internal pressure of the bead components such that the bead ruptures or explodes.", "Heat may also act upon heat-sensitive polymers used as materials to construct beads.", "The methods, compositions, devices, and kits of this disclosure may be used with any suitable agent to degrade beads.", "In some embodiments, changes in temperature or pH may be used to degrade thermo-sensitive or pH-sensitive bonds within beads.", "In some embodiments, chemical degrading agents may be used to degrade chemical bonds within beads by oxidation, reduction or other chemical changes.", "For example, a chemical degrading agent may be a reducing agent, such as DTT, wherein DTT may degrade the disulfide bonds formed between a crosslinker and gel precursors, thus degrading the bead.", "In some embodiments, a reducing agent may be added to degrade the bead, which may or may not cause the bead to release its contents.", "Examples of reducing agents may include dithiothreitol (DTT), β-mercaptoethanol, (2S)-2-amino-1,4-dimercaptobutane (dithiobutylamine or DTBA), tris(2-carboxyethyl) phosphine (TCEP), or combinations thereof.", "The reducing agent may be present at a concentration of about 0.1 mM, 0.5 mM, 1 mM, 5 mM, or 10 mM.", "The reducing agent may be present at a concentration of at least about 0.1 mM, 0.5 mM, 1 mM, 5 mM, 10 mM, or greater.", "The reducing agent may be present at concentration of at most about 0.1 mM, 0.5 mM, 1 mM, 5 mM, or 10 mM.", "Any suitable number of nucleic acid molecules (e.g., primer, barcoded oligonucleotide, anchor oligonucleotide) can be associated with a bead such that, upon release from the bead, the nucleic acid molecules (e.g., primer, barcoded oligonucleotide, anchor oligonucleotide) are present in the partition at a pre-defined concentration.", "Such pre-defined concentration may be selected to facilitate certain reactions for generating a sequencing library, e.g., amplification, within the partition.", "In some cases, the pre-defined concentration of the primer is limited by the process of producing oligonucleotide bearing beads.", "In some aspects, the partitions refer to containers or vessels (such as wells, microwells, tubes, vials, through ports in nanoarray substrates, e.g., BioTrove nanoarrays, or other containers).", "In some aspects, the compartments or partitions comprise partitions that are flowable within fluid streams.", "These partitions may comprise, e.g., micro-vesicles that have an outer barrier surrounding an inner fluid center or core, or, in some cases, they may comprise a porous matrix that is capable of entraining and/or retaining materials within its matrix.", "In some aspects, partitions comprise droplets of aqueous fluid within a non-aqueous continuous phase, e.g., an oil phase.", "Examples of different vessels are described in U.S. Patent Application Publication No.", "2014/0155295, which is entirely incorporated herein by reference for all purposes.", "Examples of emulsion systems for creating stable droplets in non-aqueous or oil continuous phases are described in detail in U.S. Patent Application Publication No.", "2010/0105112, which is entirely incorporated herein by reference for all purposes.", "In the case of droplets in an emulsion, allocating individual cells to discrete partitions may generally be accomplished by introducing a flowing stream of cells in an aqueous fluid into a flowing stream of a non-aqueous fluid, such that droplets are generated at the junction of the two streams.", "By providing the aqueous cell-containing stream at a certain concentration of cells, the occupancy of the resulting partitions (e.g., number of cells per partition) can be controlled.", "Where single cell partitions are implemented, the relative flow rates of the fluids can be selected such that, on average, the partitions contain less than one cell per partition, in order to ensure that those partitions that are occupied, are primarily singly occupied.", "In some embodiments, the relative flow rates of the fluids can be selected such that a majority of partitions are occupied, e.g., allowing for only a small percentage of unoccupied partitions.", "In some aspects, the flows and channel architectures are controlled as to ensure a number of singly occupied partitions, less than a certain level of unoccupied partitions and less than a certain level of multiply occupied partitions.", "The systems and methods described herein can be operated such that a majority of occupied partitions include no more than one cell per occupied partition.", "In some cases, the partitioning process is conducted such that fewer than 25% of the occupied partitions contain more than one cell, and in some cases, fewer than 20% of the occupied partitions have more than one cell.", "In some cases, fewer than 10% or fewer than 5% of the occupied partitions include more than one cell per partition.", "In some cases, it can be useful to avoid the creation of excessive numbers of empty partitions.", "For example, from a cost perspective and/or efficiency perspective, it may helpful to minimize the number of empty partitions.", "While this may be accomplished by providing sufficient numbers of cells into the partitioning zone, the Poissonian distribution may expectedly increase the number of partitions that may include multiple cells.", "As such, in accordance with aspects described herein, the flow of one or more of the cells, or other fluids directed into the partitioning zone are conducted such that, in some cases, no more than 50% of the generated partitions, no more than 25% of the generated partitions, or no more than 10% of the generated partitions are unoccupied.", "Further, in some aspects, these flows are controlled so as to present non-Poissonian distribution of single occupied partitions while providing lower levels of unoccupied partitions.", "The above ranges of unoccupied partitions can be achieved while still providing any of the single occupancy rates described above.", "For example, the use of the systems and methods described herein creates resulting partitions that have multiple occupancy rates of less than or equal to about 25%, 20%, 15%, 10%, or 5%, while having unoccupied partitions of less than or equal to about 50%, 40%, 30%, 20%, 10%, or 5%.", "As will be appreciated, the above-described occupancy rates are also applicable to partitions that include both cells and additional reagents and agents, including, but not limited to, microcapsules carrying barcoded oligonucleotides, microcapsules carrying anchoring oligonucleotides, labelling agents, labelling agents comprising reporter oligonucleotides, labelling agents comprising reporter oligonucleotides comprising a nucleic barcode sequence, and cells with one or more labelling agents bound to one or more cell surface features.", "In some aspects, a substantial percentage of the overall occupied partitions can include a microcapsule (e.g., bead) comprising barcodes or anchoring oligonucleotides and a cell with or without bound labelling agents.", "Although described in terms of providing substantially singly occupied partitions, above, in certain cases, it can be useful to provide multiply occupied partitions, e.g., containing two, three, four or more cells and/or microcapsules (e.g., beads) comprising barcoded oligonucleotides or anchor oligonucleotides within a single partition.", "Accordingly, the flow characteristics of the cell and/or bead containing fluids and partitioning fluids may be controlled to provide for such multiply occupied partitions.", "In particular, the flow parameters may be controlled to provide an occupancy rate at greater than or equal to about 50% of the partitions, greater than or equal to about 75%, or greater than or equal to about 80%, 90%, 95%, or higher.", "In some cases, additional microcapsules are used to deliver additional reagents to a partition.", "In such cases, it may be advantageous to introduce different beads into a common channel or droplet generation junction, from different bead sources, i.e., containing different associated reagents, through different channel inlets into such common channel or droplet generation junction.", "In such cases, the flow and frequency of the different beads into the channel or junction may be controlled to provide for a suitable ratio of microcapsules from each source, while ensuring the pairing or combination of such beads into a partition with the number of cells.", "The partitions described herein may comprise small volumes, e.g., less than or equal to 10 μL, 5 μL, 1 μL, 900 picoliters (pL), 800 pL, 700 pL, 600 pL, 500 pL, 400 pL, 300 pL, 200 pL, 100 pL, 50 pL, 20 pL, 10 pL, 1 pL, 500 nanoliters (nL), 100 nL, 50 nL, or less.", "For example, in the case of droplet based partitions, the droplets may have overall volumes that are less than or equal to 1000 pL, 900 pL, 800 pL, 700 pL, 600 pL, 500 pL, 400 pL, 300 pL, 200 pL, 100 pL, 50 pL, 20 pL, 10 pL, or 1 pL.", "Where co-partitioned with microcapsules, it will be appreciated that the sample fluid volume, e.g., including co-partitioned cells, within the partitions may be less than or equal to 90%, 80%, 70%, 60%, 50%, 40%, 30%, 20%, 10%, or less than the above described volumes.", "As is described elsewhere herein, partitioning species may generate a population or plurality of partitions.", "In such cases, any suitable number of partitions can be generated to generate the plurality of partitions.", "For example, in a method described herein, a plurality of partitions may be generated that comprises at least about 1,000 partitions, at least about 5,000 partitions, at least about 10,000 partitions, at least about 50,000 partitions, at least about 100,000 partitions, at least about 500,000 partitions, at least about 1,000,000 partitions, at least about 5,000,000 partitions at least about 10,000,000 partitions, at least about 50,000,000 partitions, at least about 100,000,000 partitions, at least about 500,000,000 partitions or at least about 1,000,000,000 partitions.", "Moreover, the plurality of partitions may comprise both unoccupied partitions (e.g., empty partitions) and occupied partitions Microfluidic channel networks can be utilized to generate partitions as described herein.", "Alternative mechanisms may also be employed in the partitioning of individual cells, including porous membranes through which aqueous mixtures of cells are extruded into non-aqueous fluids.", "An example of a simplified microfluidic channel structure for partitioning individual cells is illustrated in FIG.", "1.Cells may be partitioned with or without labelling agents bound to cell surface features, as described herein.", "As described herein, in some cases, the majority of occupied partitions include no more than one cell per occupied partition and, in some cases, some of the generated partitions are unoccupied.", "In some cases, though, some of the occupied partitions may include more than one cell.", "In some cases, the partitioning process may be controlled such that fewer than 25% of the occupied partitions contain more than one cell, and in some cases, fewer than 20% of the occupied partitions have more than one cell, while in some cases, fewer than 10% or fewer than 5% of the occupied partitions include more than one cell per partition.", "As shown, the channel structure can include channel segments 102, 104, 106 and 108 communicating at a channel junction 110.In operation, a first aqueous fluid 112 that includes suspended cells 114, may be transported along channel segment 102 into junction 110, while a second fluid 116 that is immiscible with the aqueous fluid 112 is delivered to the junction 110 from channel segments 104 and 106 to create discrete droplets 118 of the aqueous fluid including individual cells 114, flowing into channel segment 108.In some aspects, this second fluid 116 comprises an oil, such as a fluorinated oil, that includes a fluorosurfactant for stabilizing the resulting droplets, e.g., inhibiting subsequent coalescence of the resulting droplets.", "Examples of partitioning fluids and fluorosurfactants are described in U.S. Patent Application Publication No.", "2010/0105112, which is entirely incorporated herein by reference for all purposes.", "In other aspects, in addition to or as an alternative to droplet based partitioning, cells (with or without labelling agents bound to cell surface features, as described herein) may be encapsulated within a microcapsule that comprises an outer shell or layer or porous matrix in which is entrained one or more individual cells or small groups of cells, and may include other reagents.", "Encapsulation of cells may be carried out by a variety of processes.", "Such processes combine an aqueous fluid containing the cells to be analyzed with a polymeric precursor material that may be capable of being formed into a gel or other solid or semi-solid matrix upon application of a particular stimulus to the polymer precursor.", "Such stimuli include, e.g., thermal stimuli (either heating or cooling), photo-stimuli (e.g., through photo-curing), chemical stimuli (e.g., through crosslinking, polymerization initiation of the precursor (e.g., through added initiators), or the like.", "Preparation of microcapsules comprising cells may be carried out by a variety of methods.", "For example, air knife droplet or aerosol generators may be used to dispense droplets of precursor fluids into gelling solutions in order to form microcapsules that include individual cells or small groups of cells.", "Likewise, membrane based encapsulation systems may be used to generate microcapsules comprising encapsulated cells as described herein.", "In some aspects, microfluidic systems like that shown in FIG.", "1 may be readily used in encapsulating cells as described herein.", "In particular, and with reference to FIG.", "1, the aqueous fluid comprising the cells and the polymer precursor material is flowed into channel junction 110, where it is partitioned into droplets 118 comprising the individual cells 114, through the flow of non-aqueous fluid 116.In the case of encapsulation methods, non-aqueous fluid 116 may also include an initiator to cause polymerization and/or crosslinking of the polymer precursor to form the microcapsule that includes the entrained cells.", "Examples of polymer precursor/initiator pairs are described in U.S. Patent Application Publication No.", "2014/0378345, which is entirely incorporated herein by reference for all purposes.", "For example, in the case where the polymer precursor material comprises a linear polymer material, e.g., a linear polyacrylamide, PEG, or other linear polymeric material, the activation agent may comprise a cross-linking agent, or a chemical that activates a cross-linking agent within the formed droplets.", "Likewise, for polymer precursors that comprise polymerizable monomers, the activation agent may comprise a polymerization initiator.", "For example, in certain cases, where the polymer precursor comprises a mixture of acrylamide monomer with a N,N′-bis-(acryloyl)cystamine (BAC) co-monomer, an agent such as tetraethylmethylenediamine (TEMED) may be provided within the second fluid streams in channel segments 104 and 106, which initiates the copolymerization of the acrylamide and BAC into a cross-linked polymer network or, hydrogel.", "Upon contact of the second fluid stream 116 with the first fluid stream 112 at junction 110 in the formation of droplets, the TEMED may diffuse from the second fluid 116 into the aqueous first fluid 112 comprising the linear polyacrylamide, which will activate the crosslinking of the polyacrylamide within the droplets, resulting in the formation of the gel, e.g., hydrogel, microcapsules 118, as solid or semi-solid beads or particles entraining the cells 114.Although described in terms of polyacrylamide encapsulation, other ‘activatable’ encapsulation compositions may also be employed in the context of the methods and compositions described herein.", "For example, formation of alginate droplets followed by exposure to divalent metal ions, e.g., Ca2+, can be used as an encapsulation process using the described processes.", "Likewise, agarose droplets may also be transformed into capsules through temperature based gelling, e.g., upon cooling, or the like.", "In some cases, encapsulated cells can be selectively releasable from the microcapsule, e.g., through passage of time, or upon application of a particular stimulus, that degrades the microcapsule sufficiently to allow the cell, or its contents to be released from the microcapsule, e.g., into a partition, such as a droplet.", "For example, in the case of the polyacrylamide polymer described above, degradation of the microcapsule may be accomplished through the introduction of an appropriate reducing agent, such as DTT or the like, to cleave disulfide bonds that cross link the polymer matrix.", "See, e.g., U.S. Patent Application Publication No.", "2014/0378345, which is entirely incorporated herein by reference for all purposes.", "Encapsulated cells or cell populations provide certain potential advantages of being storable, and more portable than droplet based partitioned cells.", "Furthermore, in some cases, it may cells to be analyzed can be incubated for a select period of time, in order to characterize changes in such cells over time, either in the presence or absence of different stimuli.", "In such cases, encapsulation of individual cells may allow for longer incubation than partitioning in emulsion droplets, although in some cases, droplet partitioned cells may also be incubated for different periods of time, e.g., at least 10 seconds, at least 30 seconds, at least 1 minute, at least 5 minutes, at least 10 minutes, at least 30 minutes, at least 1 hour, at least 2 hours, at least 5 hours, or at least 10 hours or more.", "The encapsulation of cells may constitute the partitioning of the cells into which other reagents are co-partitioned.", "Alternatively, encapsulated cells may be readily deposited into other partitions, e.g., droplets, as described above.", "In accordance with certain aspects, the cells may be partitioned along with lysis reagents in order to release the contents of the cells within the partition.", "In such cases, the lysis agents can be contacted with the cell suspension concurrently with, or immediately prior to the introduction of the cells into the partitioning junction/droplet generation zone, e.g., through an additional channel or channels upstream of channel junction 110.Examples of lysis agents include bioactive reagents, such as lysis enzymes that are used for lysis of different cell types, e.g., gram positive or negative bacteria, plants, yeast, mammalian, etc., such as lysozymes, achromopeptidase, lysostaphin, labiase, kitalase, lyticase, and a variety of other lysis enzymes available from, e.g., Sigma-Aldrich, Inc. (St Louis, Mo.", "), as well as other commercially available lysis enzymes.", "Other lysis agents may additionally or alternatively be co-partitioned with the cells to cause the release of the cell's contents into the partitions.", "For example, in some cases, surfactant based lysis solutions may be used to lyse cells.", "In some cases, lysis solutions may include non-ionic surfactants such as, for example, TritonX-100 and Tween 20.In some cases, lysis solutions may include ionic surfactants such as, for example, sarcosyl and sodium dodecyl sulfate (SDS).", "Electroporation, thermal, acoustic or mechanical cellular disruption may also be used in certain cases, e.g., non-emulsion based partitioning such as encapsulation of cells that may be in addition to or in place of droplet partitioning, where any pore size of the encapsulate is sufficiently small to retain nucleic acid fragments of a suitable size, following cellular disruption.", "In addition to the lysis agents co-partitioned with the cells described above, other reagents can also be co-partitioned with the cells, including, for example, DNase and RNase inactivating agents or inhibitors, such as proteinase K, chelating agents, such as EDTA, and other reagents employed in removing or otherwise reducing negative activity or impact of different cell lysate components on subsequent processing of nucleic acids.", "In addition, in the case of encapsulated cells, the cells may be exposed to an appropriate stimulus to release the cells or their contents from a co-partitioned microcapsule.", "For example, in some cases, a chemical stimulus may be co-partitioned along with an encapsulated cell to allow for the degradation of the microcapsule and release of the cell or its contents into the larger partition.", "In some cases, this stimulus may be the same as the stimulus described elsewhere herein for release of oligonucleotides from their respective microcapsule (e.g., bead).", "In alternative aspects, this may be a different and non-overlapping stimulus, in order to allow an encapsulated cell to be released into a partition at a different time from the release of oligonucleotides into the same partition.", "Additional reagents may also be co-partitioned with the cells, such as endonucleases to fragment the cell's DNA, DNA polymerase enzymes and dNTPs used to amplify the cell's nucleic acid fragments and to attach the barcode oligonucleotides to the amplified fragments.", "Additional reagents may also include reverse transcriptase enzymes, including enzymes with terminal transferase activity, primers and oligonucleotides, and switch oligonucleotides (also referred to herein as “switch oligos” or “template switching oligonucleotides”) which can be used for template switching.", "In some cases, template switching can be used to increase the length of a cDNA.", "In some cases, template switching can be used to append a predefined nucleic acid sequence to the cDNA.", "In one example of template switching, cDNA can be generated from reverse transcription of a template, e.g., cellular mRNA, where a reverse transcriptase with terminal transferase activity can add additional nucleotides, e.g., polyC, to the cDNA in a template independent manner.", "Switch oligos can include sequences complementary to the additional nucleotides, e.g., polyG.", "The additional nucleotides (e.g., polyC) on the cDNA can hybridize to the additional nucleotides (e.g., polyG) on the switch oligo, whereby the switch oligo can be used by the reverse transcriptase as template to further extend the cDNA.", "Template switching oligonucleotides may comprise a hybridization region and a template region.", "The hybridization region can comprise any sequence capable of hybridizing to the target.", "In some cases, as previously described, the hybridization region comprises a series of G bases to complement the overhanging C bases at the 3′ end of a cDNA molecule.", "The series of G bases may comprise 1 G base, 2 G bases, 3 G bases, 4 G bases, 5 G bases or more than 5 G bases.", "The template sequence can comprise any sequence to be incorporated into the cDNA.", "In some cases, the template region comprises at least 1 (e.g., at least 2, 3, 4, 5 or more) tag sequences and/or functional sequences.", "Switch oligos may comprise deoxyribonucleic acids; ribonucleic acids; modified nucleic acids including 2-Aminopurine, 2,6-Diaminopurine (2-Amino-dA), inverted dT, 5-Methyl dC, 2′-deoxylnosine, Super T (5-hydroxybutynl-2′-deoxyuridine), Super G (8-aza-7-deazaguanosine), locked nucleic acids (LNAs), unlocked nucleic acids (UNAs, e.g., UNA-A, UNA-U, UNA-C, UNA-G), Iso-dG, Iso-dC, 2′ Fluoro bases (e.g., Fluoro C, Fluoro U, Fluoro A, and Fluoro G), or any combination.", "In some cases, the length of a switch oligo may be 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250 nucleotides or longer.", "In some cases, the length of a switch oligo may be at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249 or 250 nucleotides or longer.", "In some cases, the length of a switch oligo may be at most 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249 or 250 nucleotides.", "Additional agents may also be co-partitioned with the cells, such as one or more labelling agents capable of binding to one or more cell surface features of the cell(s).", "Cell surface features may comprise a receptor, an antigen, a surface protein, a transmembrane protein, a cluster of differentiation protein, a protein channel, a protein pump, a carrier protein, a phospholipid, a glycoprotein, a glycolipid, a cell-cell interaction protein complex, an antigen-presenting complex, a major histocompatibility complex, an engineered T-cell receptor, a T-cell receptor, a B-cell receptor, a chimeric antigen receptor, a gap junction, and an adherens junction.", "The labelling agents may comprise an antibody, and antibody fragment, a cell surface receptor binding molecule, a receptor ligand, a small molecule, a bi-specific antibody, a bi-specific T-cell engager, a T-cell receptor engager, a B-cell receptor engager, a pro-body, an aptamer, a monobody, an affimer, a darpin, and a protein scaffold.", "The labelling agents may be coupled, through the coupling approaches as described herein, to a reporter oligonucleotide comprising a nucleic acid barcode sequence that permits identification of the labelling agent, as described herein.", "In some embodiments, the nucleic acid barcode sequence coupled to the labelling agent may comprise a unique molecular identifier (UMI) sequence segment, as described herein.", "A labelling agent may comprise an antigen presenting particle.", "In some cases, an antigen presenting particle may comprise an antigen on or adjacent to its surface.", "The antigen presenting particle may bind to one or more molecules on the surface of a cell in a sample, e.g., through the antigen on the antigen presenting particle.", "In some cases, an antigen presenting particle may be used as a labelling agent for an immune cell, e.g., a T cell or a B cell.", "Such antigen presenting particle may bind to a T cell receptor and/or B cell receptor.", "In some cases, the antigen presenting particle comprise an antigen that is recognized (e.g., bound) by an immune cell.", "The antigen presenting particle may be a cell, e.g., a cancer cell.", "The antigen presenting particle may be a pathogen, e.g., a bacterium, a fungus, a microbe or a virus.", "In certain cases, the antigen presenting particle (e.g., a cell or a virus) may comprise an antigen expression vector that expresses the antigen on the surface of the particle.", "The antigen expression vector may comprise a barcode for identifying the nucleic acid or amino acid sequence of the antigen.", "An example method for using an antigen presenting particle to analyze a cell may comprise one or more of the following operations.", "A sample comprising immune cells (e.g., blood or a fraction thereof) are mixed with a population of antigen presenting particles, and incubated to allow for the immune cells and antigen presenting particles to interact.", "The immune cells and antigen presenting particles bound to the immune cells are purified using an antibody that selectively binds to the immune cells.", "The bound immune cells and antigen presenting particles are partitioned into droplets with beads (e.g., gel beads).", "Each of the beads comprises anchor oligonucleotide comprising a primer for mRNA molecules, a barcode and a UMI.", "At least one of the droplets contains an immune cell, an antigen presenting particle, and a gel bead.", "The immune cell and the antigen presenting particle in the droplet are lysed.", "The mRNA molecules from the immune cell and the antigen presenting particle are released.", "Reverse transcription is performed with the mRNA molecules and the anchor oligonucleotide from the bead.", "Thus, the resulting cDNA are tagged with the barcode and UMI from the anchor oligonucleotide.", "The resulting cDNA are then sequenced, e.g., to a high depth per cell on a sequencer (e.g., an Illumina sequencer).", "With the sequence reads, V(D)J regions of the immune cell are assembled and characteristics of the antigen presenting particle are also determined.", "When the antigen presenting particles are cancer cells, mutations and/or single-nucleotide polymorphisms (SNPs) may be determined with the sequence reads to identify a sub-populations of tumor cells that are targeted by an immune cell with the corresponding V(D)J sequences.", "When the antigen presenting particles are viruses, viral genome may be assembled to identify the sub-clone of viruses that are targeted by the immune cells with the corresponding V(D)J sequences.", "The method may yield pairs of V(D)J sequences and antigen-identifying sequences (e.g., mRNA of tumor cells or the genome of viruses) that are useful in developing personalized immunotherapies or vaccines against specific viral strains.", "A protein labeled by a labelling agent (e.g., an antibody labeled by a barcode) may be used as a probe in a binding assay.", "The protein may be an antibody or a cell surface protein, e.g., a cell receptor such as a T-cell receptor and B-cell receptor.", "The labelling agent may comprise a barcode and/or a UMI.", "In some cases, another labelling agent comprising the same barcode and/or UMI may be used to analyze nucleic acids from the same cell as the protein.", "The nucleic acids and the protein from the same cell may be identified by the barcode and/or UMI.", "In some cases, the nucleic acid sequence of the cell surface protein may be determined using the labelling agent for analyzing nucleic acids, so that the amino acid sequence of the cell surface protein may also be determined.", "The labeled protein from the cell may then be used as a probe in a binding assay against a target molecule (e.g., a protein).", "For example, in the binding assay, whether the labeled cell surface protein can bind to the target protein may be determined.", "The label of the cell surface protein may be separated from the cell surface protein, e.g., by denaturation.", "Then the barcode and/or UMI on the label may be sequenced.", "The sequences of the barcode and/or UMI may be used to correlate the binding assay result with the sequence of the cell surface protein.", "Thus, the interaction of the protein with the target molecule may be correlated with the sequence of the protein.", "In some cases, the interaction between the protein and the target molecule may be quantified using the UMI.", "Once the contents of the cells are released into their respective partitions, the nucleic acids contained therein may be further processed within the partitions.", "In accordance with the methods and systems described herein, the nucleic acid contents of individual cells can be provided with unique identifiers such that, upon characterization of those nucleic acids they may be attributed as having been derived from the same cell or cells.", "The ability to attribute characteristics to individual cells or groups of cells is provided by the assignment of unique identifiers specifically to an individual cell or groups of cells.", "Unique identifiers, e.g., in the form of nucleic acid barcodes can be assigned or associated with individual cells or populations of cells, in order to tag or label the cell's components (and as a result, its characteristics) with the unique identifiers.", "These unique identifiers can then be used to attribute the cell's components and characteristics to an individual cell or group of cells.", "In some aspects, this is carried out by co-partitioning the individual cells or groups of cells with the unique identifiers.", "In some aspects, the unique identifiers are provided in the form of oligonucleotides (also referred to herein as anchor oligonucleotides) that comprise nucleic acid barcode sequences that may be attached to or otherwise associated with the nucleic acid contents of individual cells, or to other components of the cells, and particularly to fragments of those nucleic acids.", "The oligonucleotides may be partitioned such that as between oligonucleotides in a given partition, the nucleic acid barcode sequences contained therein are the same, but as between different partitions, the oligonucleotides can, and do have differing barcode sequences, or at least represent a large number of different barcode sequences across all of the partitions in a given analysis.", "In some aspects, only one nucleic acid barcode sequence can be associated with a given partition, although in some cases, two or more different barcode sequences may be present.", "The nucleic acid barcode sequences can include from 6 to about 20 or more nucleotides within the sequence of the oligonucleotides.", "In some cases, the length of a barcode sequence may be 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 nucleotides or longer.", "In some cases, the length of a barcode sequence may be at least 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 nucleotides or longer.", "In some cases, the length of a barcode sequence may be at most 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 nucleotides or shorter.", "These nucleotides may be completely contiguous, i.e., in a single stretch of adjacent nucleotides, or they may be separated into two or more separate subsequences that are separated by 1 or more nucleotides.", "In some cases, separated barcode subsequences can be from about 4 to about 16 nucleotides in length.", "In some cases, the barcode subsequence may be 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 nucleotides or longer.", "In some cases, the barcode subsequence may be at least 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 nucleotides or longer.", "In some cases, the barcode subsequence may be at most 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 nucleotides or shorter.", "The co-partitioned oligonucleotides can also comprise other functional sequences useful in the processing of the nucleic acids from the co-partitioned cells.", "These sequences include, e.g., targeted or random/universal amplification primer sequences for amplifying the genomic DNA from the individual cells within the partitions while attaching the associated barcode sequences, sequencing primers or primer recognition sites, hybridization or probing sequences, e.g., for identification of presence of the sequences or for pulling down barcoded nucleic acids, or any of a number of other potential functional sequences.", "Other mechanisms of co-partitioning oligonucleotides may also be employed, including, e.g., coalescence of two or more droplets, where one droplet contains oligonucleotides, or microdispensing of oligonucleotides into partitions, e.g., droplets within microfluidic systems.", "Co-partitioning of oligonucleotides and associated barcodes and other functional sequences or labels, along with sample materials as describe herein, may be performed, for example, as described in U.S. Patent Application Publication No.", "2014/0227684, which is entirely incorporated herein by reference for all purposes.", "Briefly, in one example, microcapsules, such as beads, are provided that each include large numbers of the above described barcoded oligonucleotides (also referred to herein as anchor oligonucleotides) releasably attached to the beads, where all of the oligonucleotides attached to a particular bead will include the same nucleic acid barcode sequence, but where a large number of diverse barcode sequences are represented across the population of beads used.", "In some embodiments, hydrogel beads, e.g., comprising polyacrylamide polymer matrices, are used as a solid support and delivery vehicle for the oligonucleotides into the partitions, as they are capable of carrying large numbers of oligonucleotide molecules, and may be configured to release those oligonucleotides upon exposure to a particular stimulus, as described elsewhere herein.", "In some cases, the population of beads will provide a diverse barcode sequence library that includes at least 1,000 different barcode sequences, at least 5,000 different barcode sequences, at least 10,000 different barcode sequences, at least at least 50,000 different barcode sequences, at least 100,000 different barcode sequences, at least 1,000,000 different barcode sequences, at least 5,000,000 different barcode sequences, or at least 10,000,000 different barcode sequences.", "Additionally, each bead can be provided with large numbers of oligonucleotide molecules attached.", "In particular, the number of molecules of oligonucleotides including the barcode sequence on an individual bead can be at least 1,000 oligonucleotide molecules, at least 5,000 oligonucleotide molecules, at least 10,000 oligonucleotide molecules, at least 50,000 oligonucleotide molecules, at least 100,000 oligonucleotide molecules, at least 500,000 oligonucleotides, at least 1,000,000 oligonucleotide molecules, at least 5,000,000 oligonucleotide molecules, at least 10,000,000 oligonucleotide molecules, at least 50,000,000 oligonucleotide molecules, at least 100,000,000 oligonucleotide molecules, and in some cases at least 1 billion oligonucleotide molecules.", "Moreover, when the population of beads is partitioned, the resulting population of partitions can also include a diverse barcode library that includes at least 1,000 different barcode sequences, at least 5,000 different barcode sequences, at least 10,000 different barcode sequences, at least at least 50,000 different barcode sequences, at least 100,000 different barcode sequences, at least 1,000,000 different barcode sequences, at least 5,000,000 different barcode sequences, or at least 10,000,000 different barcode sequences.", "Additionally, each partition of the population can include at least 1,000 oligonucleotide molecules, at least 5,000 oligonucleotide molecules, at least 10,000 oligonucleotide molecules, at least 50,000 oligonucleotide molecules, at least 100,000 oligonucleotide molecules, at least 500,000 oligonucleotides, at least 1,000,000 oligonucleotide molecules, at least 5,000,000 oligonucleotide molecules, at least 10,000,000 oligonucleotide molecules, at least 50,000,000 oligonucleotide molecules, at least 100,000,000 oligonucleotide molecules, and in some cases at least 1 billion oligonucleotide molecules.", "In some cases, multiple different barcodes can be incorporated within a given partition, either attached to a single or multiple beads within the partition.", "For example, in some cases, a mixed, but known barcode sequences set may provide greater assurance of identification in the subsequent processing, e.g., by providing a stronger address or attribution of the barcodes to a given partition, as a duplicate or independent confirmation of the output from a given partition.", "The oligonucleotides may be releasable from the beads upon the application of a particular stimulus to the beads.", "In some cases, the stimulus may be a photo-stimulus, e.g., through cleavage of a photo-labile linkage that releases the oligonucleotides.", "In other cases, a thermal stimulus may be used, where elevation of the temperature of the beads environment will result in cleavage of a linkage or other release of the oligonucleotides form the beads.", "In still other cases, a chemical stimulus is used that cleaves a linkage of the oligonucleotides to the beads, or otherwise results in release of the oligonucleotides from the beads.", "In one case, such compositions include the polyacrylamide matrices described above for encapsulation of cells, and may be degraded for release of the attached oligonucleotides through exposure to a reducing agent, such as DTT.", "Examples of other systems and methods are described in U.S. Patent Application Publication No.", "2014/0155295 and US.", "Patent Application Publication No.", "2014/0378345, each of which is entirely incorporated herein by reference for all purposes.", "In accordance with the methods and systems described herein, the beads including the attached oligonucleotides may be co-partitioned with the individual cells, such that a single bead and a single cell are contained within an individual partition.", "While single cell/single bead occupancy is one possible state, it will be appreciated that multiply occupied partitions (either in terms of cells, beads or both), or unoccupied partitions (either in terms of cells, beads or both) may often be present.", "An example of a microfluidic channel structure for co-partitioning cells and beads comprising barcode oligonucleotides is schematically illustrated in FIG.", "2.As described elsewhere herein, in some aspects, a substantial percentage of the overall occupied partitions may include both a bead and a cell and, in some cases, some of the partitions that are generated may be unoccupied.", "In some cases, some of the partitions may have beads and cells that are not partitioned 1:1.In some cases, multiply occupied partitions may be provided, e.g., containing two, three, four or more cells and/or beads within a single partition.", "As shown, channel segments 202, 204, 206, 208 and 210 are provided in fluid communication at channel junction 212.An aqueous stream comprising the individual cells 214, is flowed through channel segment 202 toward channel junction 212.As described above, these cells may be suspended within an aqueous fluid, or may have been pre-encapsulated, prior to the partitioning process.", "Concurrently, an aqueous stream comprising the barcode carrying beads 216, is flowed through channel segment 204 toward channel junction 212.A non-aqueous partitioning fluid 216 is introduced into channel junction 212 from each of side channels 206 and 208, and the combined streams are flowed into outlet channel 210.Within channel junction 212, the two combined aqueous streams from channel segments 202 and 204 are combined, and partitioned into droplets 218, that include co-partitioned cells 214 and beads 216.By controlling the flow characteristics of each of the fluids combining at channel junction 212, as well as controlling the geometry of the channel junction, partitioning can be optimized to achieve a suitable occupancy level of beads, cells or both, within the partitions 218 that are generated.", "In some cases, lysis agents, e.g., cell lysis enzymes, may be introduced into the partition with the bead stream, e.g., flowing through channel segment 204, such that the cell may be lysed at or after the time of partitioning.", "In some cases, cell membranes are maintained intact, such as to allow for the characterization of cell surface markers, as described later herein.", "Additional reagents may also be added to the partition in this configuration, such as endonucleases to fragment the cell's DNA, DNA polymerase enzyme and dNTPs used to amplify the cell's nucleic acid fragments and to attach the barcode oligonucleotides to the amplified fragments.", "A chemical stimulus, such as DTT, may be used to release the barcodes from their respective beads into the partition.", "In such cases, the chemical stimulus can be provided along with the cell-containing stream in channel segment 202, such that release of the barcodes only occurs after the two streams have been combined, e.g., within the partitions 218.Where the cells are encapsulated, however, introduction of a common chemical stimulus, e.g., that both releases the oligonucleotides form their beads, and releases cells from their microcapsules may generally be provided from a separate additional side channel (not shown) upstream of or connected to channel junction 212.A number of other reagents may be co-partitioned along with the cells, beads, lysis agents and chemical stimuli, including, for example, protective reagents, like proteinase K, chelators, nucleic acid extension, replication, transcription or amplification reagents such as polymerases, reverse transcriptases, transposases which can be used for transposon based methods (e.g., Nextera), nucleoside triphosphates or NTP analogues, primer sequences and additional cofactors such as divalent metal ions used in such reactions, ligation reaction reagents, such as ligase enzymes and ligation sequences, dyes, labels, or other tagging reagents.", "The channel networks, e.g., as described herein, can be fluidly coupled to appropriate fluidic components.", "For example, the inlet channel segments, e.g., channel segments 202, 204, 206 and 208 are fluidly coupled to appropriate sources of the materials they are to deliver to channel junction 212.For example, channel segment 202 may be fluidly coupled to a source of an aqueous suspension of cells 214 to be analyzed, while channel segment 204 may be fluidly coupled to a source of an aqueous suspension of beads 216.Channel segments 206 and 208 may then be fluidly connected to one or more sources of the non-aqueous fluid.", "These sources may include any of a variety of different fluidic components, from simple reservoirs defined in or connected to a body structure of a microfluidic device, to fluid conduits that deliver fluids from off-device sources, manifolds, or the like.", "Likewise, the outlet channel segment 210 may be fluidly coupled to a receiving vessel or conduit for the partitioned cells.", "Again, this may be a reservoir defined in the body of a microfluidic device, or it may be a fluidic conduit for delivering the partitioned cells to a subsequent process operation, instrument or component.", "FIG.", "8 shows images of individual Jurkat cells co-partitioned along with barcode oligonucleotide containing beads in aqueous droplets in an aqueous in oil emulsion.", "As illustrated, individual cells may be readily co-partitioned with individual beads.", "As will be appreciated, optimization of individual cell loading may be carried out by a number of methods, including by providing dilutions of cell populations into the microfluidic system in order to achieve suitable cell loading per partition as described elsewhere herein.", "In operation, once lysed, the nucleic acid contents of the individual cells are then available for further processing within the partitions, including, e.g., fragmentation, amplification and barcoding, as well as attachment of other functional sequences.", "Fragmentation may be accomplished through the co-partitioning of shearing enzymes, such as endonucleases, in order to fragment the nucleic acids into smaller fragments.", "These endonucleases may include restriction endonucleases, including type II and type IIs restriction endonucleases as well as other nucleic acid cleaving enzymes, such as nicking endonucleases, and the like.", "In some cases, fragmentation may not be implemented, and full length nucleic acids may be retained within the partitions, or in the case of encapsulated cells or cell contents, fragmentation may be carried out prior to partitioning, e.g., through enzymatic methods, e.g., those described herein, or through mechanical methods, e.g., mechanical, acoustic or other shearing.", "Once co-partitioned, and the cells are lysed to release their nucleic acids, the oligonucleotides disposed upon the bead may be used to barcode and amplify fragments of those nucleic acids.", "Briefly, in one aspect, the oligonucleotides present on the beads that are co-partitioned with the cells, are released from their beads into the partition with the cell's nucleic acids.", "The oligonucleotides can include, along with the barcode sequence, a primer sequence at its 5′end.", "This primer sequence may be a random oligonucleotide sequence intended to randomly prime numerous different regions on the cell's nucleic acids, or it may be a specific primer sequence targeted to prime upstream of a specific targeted region of the cell's genome.", "Once released, the primer portion of the oligonucleotide can anneal to a complementary region of the cell's nucleic acid.", "Extension reaction reagents, e.g., DNA polymerase, nucleoside triphosphates, co-factors (e.g., Mg2+ or Mn2+), that may also be co-partitioned with the cells and beads, then extend the primer sequence using the cell's nucleic acid as a template, to produce a complementary fragment to the strand of the cell's nucleic acid to which the primer annealed, which complementary fragment includes the oligonucleotide and its associated barcode sequence.", "Annealing and extension of multiple primers to different portions of the cell's nucleic acids will result in a large pool of overlapping complementary fragments of the nucleic acid, each possessing its own barcode sequence indicative of the partition in which it was created.", "In some cases, these complementary fragments may themselves be used as a template primed by the oligonucleotides present in the partition to produce a complement of the complement that again, includes the barcode sequence.", "In some cases, this replication process is configured such that when the first complement is duplicated, it produces two complementary sequences at or near its termini, to allow formation of a hairpin structure or partial hairpin structure that may reduce the ability of the molecule to be the basis for producing further iterative copies.", "As described herein, the cell's nucleic acids may include any nucleic acids within the cell including, for example, the cell's DNA, e.g., genomic DNA, RNA, e.g., messenger RNA, and the like.", "For example, in some cases, the methods and systems described herein are used in characterizing expressed mRNA, including, e.g., the presence and quantification of such mRNA, and may include RNA sequencing processes as the characterization process.", "Alternatively or additionally, the reagents partitioned along with the cells may include reagents for the conversion of mRNA into cDNA, e.g., reverse transcriptase enzymes and reagents, to facilitate sequencing processes where DNA sequencing is employed.", "In some cases, where the nucleic acids to be characterized comprise RNA, e.g., mRNA, schematic illustration of one example of this is shown in FIG.", "3.As shown, oligonucleotides that include a barcode sequence are co-partitioned in, e.g., a droplet 302 in an emulsion, along with a sample nucleic acid 304.The oligonucleotides 308 may be provided on a bead 306 that is co-partitioned with the sample nucleic acid 304, which oligonucleotides are releasable from the bead 306, as shown in panel A.", "The oligonucleotides 308 may include a barcode sequence 312, in addition to one or more functional sequences, e.g., sequences 310, 314 and 316.For example, oligonucleotide 308 is shown as comprising barcode sequence 312, as well as sequence 310 that may function as an attachment or immobilization sequence for a given sequencing system, e.g., a P5 sequence used for attachment in flow cells of an Illumina Hiseq® or Miseq® system.", "As shown, the oligonucleotides also include a primer sequence 316, which may include a random or targeted N-mer for priming replication of portions of the sample nucleic acid 304.Also included within oligonucleotide 308 is a sequence 314 which may provide a sequencing priming region, such as a “read1” or R1 priming region, that is used to prime polymerase mediated, template directed sequencing by synthesis reactions in sequencing systems.", "As will be appreciated, the functional sequences may be selected to be compatible with a variety of different sequencing systems, e.g., 454 Sequencing, Ion Torrent Proton or PGM, Illumina X10, etc., and the requirements thereof.", "In some cases, the barcode sequence 312, immobilization sequence 310 and R1 sequence 314 may be common to all of the oligonucleotides attached to a given bead.", "The primer sequence 316 may vary for random N-mer primers, or may be common to the oligonucleotides on a given bead for certain targeted applications.", "Moreover, in some cases, barcoded oligonucleotides may be generated as described in U.S. Patent Publication No.", "20160257984, which is herein incorporated by reference in its entirety.", "An oligonucleotide of an anchor agent or a labelling agent may comprise modifications that render it non-extendable by a polymerase.", "When binding to a nucleic acid in a sample for a primer extension reaction, the oligonucleotide may serve as a template, not a primer.", "When the oligonucleotide also comprises a barcode (e.g., the oligonucleotide is a reporter oligonucleotide), such design may increase the efficiency of molecular barcoding by increasing the affinity between the oligonucleotide and the unbarcoded sample nucleic acids, and eliminate the potential formation of adaptor artifacts.", "In some cases, the oligonucleotide may comprise a random N-mer sequence that is capped with modifications that render it non-extendable by a polymerase.", "In some cases, the composition of the random N-mer sequence may be designed to maximize the binding efficiency to free, unbarcoded ssDNA molecules.", "The design may include a random sequence composition with a higher GC content, a partial random sequence with fixed G or C at specific positions, the use of guanosines, the use of locked nucleic acids, or any combination thereof.", "A modification for blocking primer extension by a polymerase may be a carbon spacer group of different lengths or a dideoxynucleotide.", "In some cases, the modification may be an abasic site that has an apurine or apyrimidine structure, a base analog, or an analogue of a phosphate backbone, such as a backbone of N-(2-aminoethyl)-glycine linked by amide bonds, tetrahydrofuran, or 1′, 2′-Dideoxyribose.", "The modification may also be a uracil base, 2′OMe modified RNA, C3-18 spacers (e.g., structures with 3-18 consecutive carbon atoms, such as C3 spacer), ethylene eglycol multimer spacers (e.g., spacer 18 (hexa-ethyleneglycol spacer), biotin, di-deoxynucleotide triphosphate, ethylene glycol, amine, or phosphate.", "FIG.", "21 shows an oligonucleotide with such modification.", "The double-stranded oligonucleotide 2110 comprises a single-stranded DNA(ssDNA) annealing region with a random N-mer sequence at its 3′ end.", "The unbarcoded ssDNA 2120 from a sample binds to oligonucleotide 2110.The random N-mer sequence of the oligonucleotide 2110 has modifications (shown as “X”) on the 3′ end.", "When oligonucleotide 2110 and unbarcoded ssDNA 2120 bind to each other in a primer extension reaction, only unbarcoded ssDNA 2120 can be extended using oligonucleotide 3310 as a template.", "In some cases, the oligonucleotide with a random N-mer sequence may be coupled to a solid support (e.g., a bead) via a U-excising element, e.g., an ssDNA sequence with uracil.", "FIG.", "22 shows an example of such oligonucleotide.", "Double-stranded oligonucleotide 2210 comprises an ssDNA annealing region that contains a random N-mer sequence at its 3′ end.", "Oligonucleotide 2210 is coupled to a bead via an ssDNA 2211 that has a uracil.", "Oligonucleotide 2210 also comprises modifications preventing extension by a polymerase.", "Oligonucleotide 2210 may be released from the bead by uracil-DNA glycosylase (to remove the uracil) and an endonuclease (to induce the ssDNA break), resulting the released oligonucleotide 2230.Oligonucleotide 2220 comprises an ssDNA priming region has similar design as Oligonucleotide 2210.In some cases, the difference between an ssDNA annealing region and an ssDNA priming region is the presence or absence of a blocking group (e.g., “X”), respectively.", "Unblocked ssDNA can be extended and function as a primer, while blocked ssDNA can function as a passive annealing sequence.", "As will be appreciated, in some cases, the functional sequences may include primer sequences useful for RNA-seq applications.", "For example, in some cases, the oligonucleotides may include poly-T primers for priming reverse transcription of RNA for RNA-seq.", "In still other cases, oligonucleotides in a given partition, e.g., included on an individual bead, may include multiple types of primer sequences in addition to the common barcode sequences, such as both DNA-sequencing and RNA sequencing primers, e.g., poly-T primer sequences included within the oligonucleotides coupled to the bead.", "In such cases, a single partitioned cell may be both subjected to DNA and RNA sequencing processes.", "A primer on a labelling agent or an anchor agent (e.g., a primer for RNA-seq applications) may be a target-specific primer.", "A target-specific primer may bind to a specific sequence in a RNA molecule or a DNA molecule (e.g., complementary DNA (cDNA) from RNA, or endogenous DNA from a cell).", "For example, the specific sequence may be a sequence that is not in the poly-A tail of an RNA molecule or its cDNA.", "In some cases, the target-specific primer may bind to RNA molecules such as mRNA molecules or non-coding RNA molecules, e.g., rRNA, tRNA, mRNA, or miRNA molecules.", "In some cases, the target-specific primer may bind to RNA molecules introduced to a cell.", "In some cases, the RNA molecules introduced to a cell may be RNA molecules used in gene editing methods (e.g., Clustered regularly interspaced short palindromic repeats (CRISPR) RNA (crRNA) or guide RNA for CRISPR gene editing).", "For example, the target-specific primer may bind to crRNA for identifying the crRNA introduced to a cell and/or determining the effect of the crRNA on the transcriptome of the cell.", "In some cases, the target-specific primer may be used to determine copy numbers of disease (e.g., cancer)-related genes while simultaneously analyzing the rest of the transcriptome.", "In other cases, the target-specific primer may be used to analyze RNA molecules from pathogens infecting the cell, e.g., for distinguishing pathogen infected cells from non-pathogen infected cells and/or determining how the pathogen alters the cells transcriptome.", "In some cases, a target-specific primer may bind to DNA molecules, e.g., endogenous DNA molecules from a cell, or synthetic DNA molecules.", "For example, a target-specific primer may bind to a barcode, e.g., a barcode of a cell (e.g., inside a cell or on the surface of a cell), a barcode of a protein (e.g., an antibody barcode), or a barcode of a nucleic acid (e.g., a CRISPR barcode).", "A target-specific primer may be combined with one or more barcodes, one or more UMIs, one or more poly-T primers for mRNA, and/or one or more random N-mer primers (randomers) for total RNA in the same or different oligonucleotides.", "In some cases, a bead disclosed herein may comprise an oligonucleotide with a target-specific primer and one or more oligonucleotides with a poly-T primer, e.g., as shown in FIG.", "23A.", "In some cases, a bead may have a plurality of oligonucleotides, each of which comprises a target-specific primer, e.g., as shown in FIG.", "23B.", "In some cases, a bead may have a plurality of oligonucleotides, each of which comprises a target-specific primer and a plurality of oligonucleotides, each of which comprises a poly-T primer, e.g., as shown in FIG.", "23C.", "In some cases, a bead may have a plurality of oligonucleotides, each of which comprises a target-specific primer and a plurality of oligonucleotides, each of which comprises a random N-mer primer for total RNA, e.g., as shown in FIG.", "24.On a bead, the ratio of oligonucleotides with target-specific primers to oligonucleotides with non-specific (poly-T or random N-mer) primers may be adjusted to match the needs of a specific application.", "In some cases, at least 0.1%, 1%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 99%, or 100% of the oligonucleotides on a bead may comprise target-specific primers.", "In some cases, at least 0.1%, 1%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 99%, or 100% of the oligonucleotides on a bead may comprise non-specific (poly-T or random N-mer) primers.", "The oligonucleotide may be made by attaching (e.g., by ligation) one or more oligonucleotide backbones on a bead and then attaching (e.g., by ligation) one or more primer sequences to the backbones.", "An oligonucleotide of an anchor agent or a labelling agent may be a splint oligonucleotide.", "A splint oligonucleotide may comprise two or more different primers.", "The primers may have different functions.", "For example, a splint oligonucleotide may comprise two or more of the following: a poly-T primer, a random N-mer primmer, and a target-specific primer.", "An oligonucleotide of an anchor agent or a labelling agent may comprise an adapter that is capable of binding or ligating to an assay primer.", "The adapter may allow the anchor agent or the labelling agent to be attached to any suitable assay primers and used in any suitable assays.", "The assay primer may comprise priming region and a sequence that is capable of binding or ligating to the adapter.", "In some cases, the adapter may be a non-specific primer (e.g., a 5′ overhang) and the assay primer may comprise a 3′ overhang that can be ligated to the 5′ overhang.", "The priming region on the assay primer may be any primer described herein, e.g., a poly-T primer, a random N-mer primer, or a target-specific primer.", "FIG.", "25 shows adapters and assay primers.", "Oligonucleotide 2510 comprises an adapter 2511, which is a 5′ overhang comprising 10 nucleotides.", "The adapter 2511 can be ligated to the assay primers, each of which comprises a 3′ overhang comprising 10 nucleotides that complementary to the 5′ overhang of adapter 2511.The anchor oligonucleotide may be used in any assay by attaching to the assay primer designed for that assay.", "In some cases, the adapter comprise a switch oligo, e.g., with a 3′ end 3rG.", "FIG.", "26 shows an adapter comprising a switch oligo.", "Based upon the presence of primer sequence 316, the oligonucleotides can prime the sample nucleic acid as shown in panel B, which allows for extension of the oligonucleotides 308 and 308a using polymerase enzymes and other extension reagents also co-partitioned with the bead 306 and sample nucleic acid 304.As shown in panel C, following extension of the oligonucleotides that, for random N-mer primers, may anneal to multiple different regions of the sample nucleic acid 304; multiple overlapping complements or fragments of the nucleic acid are created, e.g., fragments 318 and 320.Although including sequence portions that are complementary to portions of sample nucleic acid, e.g., sequences 322 and 324, these constructs are generally referred to herein as comprising fragments of the sample nucleic acid 304, having the attached barcode sequences.", "The barcoded nucleic acid fragments may then be subjected to characterization, e.g., through sequence analysis, or they may be further amplified in the process, as shown in panel D. For example, additional oligonucleotides, e.g., oligonucleotide 308b, also released from bead 306, may prime the fragments 318 and 320.This shown for fragment 318.In particular, again, based upon the presence of the random N-mer primer 316b in oligonucleotide 308b (which in some cases can be different from other random N-mers in a given partition, e.g., primer sequence 316), the oligonucleotide anneals with the fragment 318, and is extended to create a complement 326 to at least a portion of fragment 318 which includes sequence 328, that comprises a duplicate of a portion of the sample nucleic acid sequence.", "Extension of the oligonucleotide 308b continues until it has replicated through the oligonucleotide portion 308 of fragment 318.As illustrated in panel D, the oligonucleotides may be configured to prompt a stop in the replication by the polymerase at a given point, e.g., after replicating through sequences 316 and 314 of oligonucleotide 308 that is included within fragment 318.As described herein, this may be accomplished by different methods, including, for example, the incorporation of different nucleotides and/or nucleotide analogues that are not capable of being processed by the polymerase enzyme used.", "For example, this may include the inclusion of uracil containing nucleotides within the sequence region 312 to prevent a non-uracil tolerant polymerase to cease replication of that region.", "As a result a fragment 326 is created that includes the full-length oligonucleotide 308b at one end, including the barcode sequence 312, the attachment sequence 310, the R1 primer region 314, and the random N-mer sequence 316b.", "At the other end of the sequence may be included the complement 316′ to the random N-mer of the first oligonucleotide 308, as well as a complement to all or a portion of the R1 sequence, shown as sequence 314′.", "The R1 sequence 314 and its complement 314′ are then able to hybridize together to form a partial hairpin structure 328.As will be appreciated because the random N-mers differ among different oligonucleotides, these sequences and their complements may not be expected to participate in hairpin formation, e.g., sequence 316′, which is the complement to random N-mer 316, may not be expected to be complementary to random N-mer sequence 316b.", "This may not be the case for other applications, e.g., targeted primers, where the N-mers may be common among oligonucleotides within a given partition.", "By forming these partial hairpin structures, it allows for the removal of first level duplicates of the sample sequence from further replication, e.g., preventing iterative copying of copies.", "The partial hairpin structure also provides a useful structure for subsequent processing of the created fragments, e.g., fragment 326.In general, the amplification of the cell's nucleic acids is carried out until the barcoded overlapping fragments within the partition constitute at least 1× coverage of the particular portion or all of the cell's genome, at least 2×, at least 3×, at least 4×, at least 5×, at least 10×, at least 20×, at least 40× or more coverage of the genome or its relevant portion of interest.", "Once the barcoded fragments are produced, they may be directly sequenced on an appropriate sequencing system, e.g., an Illumina Hiseq®, Miseq® or X10 system, or they may be subjected to additional processing, such as further amplification, attachment of other functional sequences, e.g., second sequencing primers, for reverse reads, sample index sequences, and the like.", "All of the fragments from multiple different partitions may then be pooled for sequencing on high throughput sequencers as described herein, where the pooled fragments comprise a large number of fragments derived from the nucleic acids of different cells or small cell populations, but where the fragments from the nucleic acids of a given cell will share the same barcode sequence.", "In particular, because each fragment is coded as to its partition of origin, and consequently its single cell or small population of cells, the sequence of that fragment may be attributed back to that cell or those cells based upon the presence of the barcode, which will also aid in applying the various sequence fragments from multiple partitions to assembly of individual genomes for different cells.", "This is schematically illustrated in FIG.", "4.As shown in one example, a first nucleic acid 404 from a first cell 400, and a second nucleic acid 406 from a second cell 402 are each partitioned along with their own sets of barcode oligonucleotides as described above.", "The nucleic acids may comprise a chromosome, entire genome or other large nucleic acid from the cells.", "Within each partition, each cell's nucleic acids 404 and 406 is then processed to separately provide overlapping set of second fragments of the first fragment(s), e.g., second fragment sets 408 and 410.This processing also provides the second fragments with a barcode sequence that is the same for each of the second fragments derived from a particular first fragment.", "As shown, the barcode sequence for second fragment set 408 is denoted by “1” while the barcode sequence for fragment set 410 is denoted by “2”.", "A diverse library of barcodes may be used to differentially barcode large numbers of different fragment sets.", "However, it is not necessary for every second fragment set from a different first fragment to be barcoded with different barcode sequences.", "In some cases, multiple different first fragments may be processed concurrently to include the same barcode sequence.", "Diverse barcode libraries are described in detail elsewhere herein.", "The barcoded fragments, e.g., from fragment sets 408 and 410, may then be pooled for sequencing using, for example, sequence by synthesis technologies available from Illumina or Ion Torrent division of Thermo-Fisher, Inc. Once sequenced, the sequence reads 412 can be attributed to their respective fragment set, e.g., as shown in aggregated reads 414 and 416, at least in part based upon the included barcodes, and in some cases, in part based upon the sequence of the fragment itself.", "The attributed sequence reads for each fragment set are then assembled to provide the assembled sequence for each cell's nucleic acids, e.g., sequences 418 and 420, which in turn, may be attributed to individual cells, e.g., cells 400 and 402.While described in terms of analyzing the genetic material present within cells, the methods and systems described herein may have much broader applicability, including the ability to characterize other aspects of individual cells or cell populations, by allowing for the allocation of reagents and/or agents to individual cells, and providing for the attributable analysis or characterization of those cells in response to those reagents and/or agents.", "These methods and systems may be valuable in being able to characterize cells for, e.g., research, diagnostic, or pathogen identification.", "By way of example, a wide range of different cell surface features, e.g., cell surface proteins like cluster of differentiation or CD proteins, have significant diagnostic relevance in characterization of diseases like cancer.", "In one particularly useful application, the methods and systems described herein may be used to characterize cell features, such as cell surface features.", "Cell surface features may include, but are not limited to, a receptor, an antigen, a surface protein, a transmembrane protein, a cluster of differentiation protein, a protein channel, a protein pump, a carrier protein, a phospholipid, a glycoprotein, a glycolipid, a cell-cell interaction protein complex, an antigen-presenting complex, a major histocompatibility complex, an engineered T-cell receptor, a T-cell receptor, a B-cell receptor, a chimeric antigen receptor, a gap junction, and an adherens junction.", "In particular, the methods described herein may be used to attach one or more labelling agents to these cell features, that when partitioned as described above, may be barcoded and analyzed, e.g., using DNA sequencing technologies, to ascertain the presence, and in some cases, relative abundance or quantity of such cell features of an individual cell or population of cells.", "In a particular example, a library of potential cell surface feature labelling agents may be provided associated with a first set of nucleic acid reporter molecules, e.g., where a different reporter oligonucleotide sequence is associated with a specific labelling agent, and therefore capable of binding to a specific cell surface feature.", "Cell surface feature labelling agents may include, but are not limited to, an antibody, an antibody fragment, a cell surface receptor binding molecule, a receptor ligand, a small molecule, a bi-specific antibody, a bi-specific T-cell engager, a T-cell receptor engager, a B-cell receptor engager, a pro-body, an aptamer, a monobody, an affimer, a darpin, and a protein scaffold.", "In some aspects, different members of the library may be characterized by the presence of a different oligonucleotide sequence label, e.g., an antibody to a first type of cell surface protein or receptor may have associated with it a first known reporter oligonucleotide sequence, while an antibody to a second receptor protein may have a different known reporter oligonucleotide sequence associated with it.", "Prior to co-partitioning, the cells may be incubated with the library of labelling agents, that may represent antibodies to a broad panel of different cell surface features, e.g., receptors, proteins, etc., and which include their associated reporter oligonucleotides.", "Unbound labelling agents may be washed from the cells, and the cells may then be co-partitioned along with the barcode oligonucleotides described above.", "As a result, the partitions may include the cell or cells, as well as the bound labelling agents and their known, associated reporter oligonucleotides.", "Without the need for lysing the cells within the partitions, one may then subject the reporter oligonucleotides to the barcoding operations described above for cellular nucleic acids, to produce barcoded, reporter oligonucleotides, where the presence of the reporter oligonucleotides can be indicative of the presence of the particular cell surface feature, and the barcode sequence will allow the attribution of the range of different cell surface features to a given individual cell or population of cells based upon the barcode sequence that was co-partitioned with that cell or population of cells.", "As a result, one may generate a cell-by-cell profile of the cell surface features within a broader population of cells.", "This aspect of the methods and systems described herein, is described in greater detail below.", "This example is schematically illustrated in FIG.", "5.As shown, a population of cells, represented by cells 502 and 504 are incubated with a library of cell surface associated labelling agents, e.g., antibodies, antibody fragments, cell surface receptor binding molecules, receptor ligands, small molecules, bi-specific antibodies, bi-specific T-cell engagers, T-cell receptor engagers, B-cell receptor engagers, pro-bodies, aptamers, monobodies, affimers, darpins, protein scaffolds, or the like, where each different type of binding group includes an associated nucleic acid reporter molecule associated with it, shown as labelling agents and associated reporter oligonucleotide 506, 508, 510 and 512 (with the reporter oligonucleotides being indicated by the differently shaded circles).", "Where the cell expresses the surface features that are bound by the library of labelling agents, the labelling agents and their associated reporter oligonucleotides can become associated or coupled with the cell surface feature.", "Individual cells may then be partitioned into separate partitions, e.g., droplets 514 and 516, as described herein, along with their associated labelling agents/reporter oligonucleotides, as well as a bead containing individual barcode oligonucleotides (e.g., anchor oligonucleotides) as described elsewhere herein, e.g., beads 518 and 520, respectively.", "As with other examples described herein, the barcoded oligonucleotides may be released from the beads and used to attach the barcode sequence the reporter oligonucleotides present within each partition with a barcode that is common to a given partition, but which varies widely among different partitions.", "For example, as shown in FIG.", "5, the reporter oligonucleotides that associate with cell 502 in partition 514 are barcoded with barcode sequence 522, while the reporter oligonucleotides associated with cell 504 in partition 516 are barcoded with barcode sequence 524.As a result, one is provided with a library of oligonucleotides that reflects the surface features of the cell, as reflected by the reporter molecule, but which is substantially attributable to an individual cell by virtue of a common barcode sequence, allowing a single cell level profiling of the surface characteristics of the cell.", "As will be appreciated, this process is not limited to cell surface receptors but may be used to identify the presence of a wide variety of specific cell structures, chemistries or other characteristics.", "Single cell processing and analysis methods and systems described herein can be utilized for a wide variety of applications, including analysis of specific individual cells, analysis of different cell types within populations of differing cell types, analysis and characterization of large populations of cells for environmental, human health, epidemiological forensic, or any of a wide variety of different applications.", "A particularly valuable application of the single cell analysis processes described herein is in the sequencing and characterization of a diseased cell.", "A diseased cell can have altered metabolic properties, gene expression, protein expression, and/or morphologic features.", "Examples of diseases include inflammatory disorders, metabolic disorders, nervous system disorders, and cancer.", "Of particular interest are cancer cells.", "In particular, conventional analytical techniques, including the ensemble sequencing processes alluded to above, are not highly adept at picking small variations in genomic make-up of cancer cells, particularly where those exist in a sea of normal tissue cells.", "Further, even as between tumor cells, wide variations can exist and can be masked by the ensemble approaches to sequencing (See, e.g., Patel, et al., Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma, Science DOI: 10.1126/science.1254257 (Published online Jun.", "12, 2014).", "Cancer cells may be derived from solid tumors, hematological malignancies, cell lines, or obtained as circulating tumor cells, and subjected to the partitioning processes described above.", "Upon analysis, one can identify individual cell sequences as deriving from a single cell or small group of cells, and distinguish those over normal tissue cell sequences.", "Non-limiting examples of cancer cells include cells of cancers such as Acanthoma, Acinic cell carcinoma, Acoustic neuroma, Acral lentiginous melanoma, Acrospiroma, Acute eosinophilic leukemia, Acute lymphoblastic leukemia, Acute megakaryoblastic leukemia, Acute monocytic leukemia, Acute myeloblastic leukemia with maturation, Acute myeloid dendritic cell leukemia, Acute myeloid leukemia, Acute promyelocytic leukemia, Adamantinoma, Adenocarcinoma, Adenoid cystic carcinoma, Adenoma, Adenomatoid odontogenic tumor, Adrenocortical carcinoma, Adult T-cell leukemia, Aggressive NK-cell leukemia, AIDS-Related Cancers, AIDS-related lymphoma, Alveolar soft part sarcoma, Ameloblastic fibroma, Anal cancer, Anaplastic large cell lymphoma, Anaplastic thyroid cancer, Angioimmunoblastic T-cell lymphoma, Angiomyolipoma, Angiosarcoma, Appendix cancer, Astrocytoma, Atypical teratoid rhabdoid tumor, Basal cell carcinoma, Basal-like carcinoma, B-cell leukemia, B-cell lymphoma, Bellini duct carcinoma, Biliary tract cancer, Bladder cancer, Blastoma, Bone Cancer, Bone tumor, Brain Stem Glioma, Brain Tumor, Breast Cancer, Brenner tumor, Bronchial Tumor, Bronchioloalveolar carcinoma, Brown tumor, Burkitt's lymphoma, Cancer of Unknown Primary Site, Carcinoid Tumor, Carcinoma, Carcinoma in situ, Carcinoma of the penis, Carcinoma of Unknown Primary Site, Carcinosarcoma, Castleman's Disease, Central Nervous System Embryonal Tumor, Cerebellar Astrocytoma, Cerebral Astrocytoma, Cervical Cancer, Cholangiocarcinoma, Chondroma, Chondrosarcoma, Chordoma, Choriocarcinoma, Choroid plexus papilloma, Chronic Lymphocytic Leukemia, Chronic monocytic leukemia, Chronic myelogenous leukemia, Chronic Myeloproliferative Disorder, Chronic neutrophilic leukemia, Clear-cell tumor, Colon Cancer, Colorectal cancer, Craniopharyngioma, Cutaneous T-cell lymphoma, Degos disease, Dermatofibrosarcoma protuberans, Dermoid cyst, Desmoplastic small round cell tumor, Diffuse large B cell lymphoma, Dysembryoplastic neuroepithelial tumor, Embryonal carcinoma, Endodermal sinus tumor, Endometrial cancer, Endometrial Uterine Cancer, Endometrioid tumor, Enteropathy-associated T-cell lymphoma, Ependymoblastoma, Ependymoma, Epithelioid sarcoma, Erythroleukemia, Esophageal cancer, Esthesioneuroblastoma, Ewing Family of Tumor, Ewing Family Sarcoma, Ewing's sarcoma, Extracranial Germ Cell Tumor, Extragonadal Germ Cell Tumor, Extrahepatic Bile Duct Cancer, Extramammary Paget's disease, Fallopian tube cancer, Fetus in fetu, Fibroma, Fibrosarcoma, Follicular lymphoma, Follicular thyroid cancer, Gallbladder Cancer, Gallbladder cancer, Ganglioglioma, Ganglioneuroma, Gastric Cancer, Gastric lymphoma, Gastrointestinal cancer, Gastrointestinal Carcinoid Tumor, Gastrointestinal Stromal Tumor, Gastrointestinal stromal tumor, Germ cell tumor, Germinoma, Gestational choriocarcinoma, Gestational Trophoblastic Tumor, Giant cell tumor of bone, Glioblastoma multiforme, Glioma, Gliomatosis cerebri, Glomus tumor, Glucagonoma, Gonadoblastoma, Granulosa cell tumor, Hairy Cell Leukemia, Hairy cell leukemia, Head and Neck Cancer, Head and neck cancer, Heart cancer, Hemangioblastoma, Hemangiopericytoma, Hemangio sarcoma, Hematological malignancy, Hepatocellular carcinoma, Hepatosplenic T-cell lymphoma, Hereditary breast-ovarian cancer syndrome, Hodgkin Lymphoma, Hodgkin's lymphoma, Hypopharyngeal Cancer, Hypothalamic Glioma, Inflammatory breast cancer, Intraocular Melanoma, Islet cell carcinoma, Islet Cell Tumor, Juvenile myelomonocytic leukemia, Kaposi Sarcoma, Kaposi's sarcoma, Kidney Cancer, Klatskin tumor, Krukenberg tumor, Laryngeal Cancer, Laryngeal cancer, Lentigo maligna melanoma, Leukemia, Leukemia, Lip and Oral Cavity Cancer, Liposarcoma, Lung cancer, Luteoma, Lymphangioma, Lymphangiosarcoma, Lymphoepithelioma, Lymphoid leukemia, Lymphoma, Macroglobulinemia, Malignant Fibrous Histiocytoma, Malignant fibrous histiocytoma, Malignant Fibrous Histiocytoma of Bone, Malignant Glioma, Malignant Mesothelioma, Malignant peripheral nerve sheath tumor, Malignant rhabdoid tumor, Malignant triton tumor, MALT lymphoma, Mantle cell lymphoma, Mast cell leukemia, Mediastinal germ cell tumor, Mediastinal tumor, Medullary thyroid cancer, Medulloblastoma, Medulloblastoma, Medulloepithelioma, Melanoma, Melanoma, Meningioma, Merkel Cell Carcinoma, Mesothelioma, Mesothelioma, Metastatic Squamous Neck Cancer with Occult Primary, Metastatic urothelial carcinoma, Mixed Mullerian tumor, Monocytic leukemia, Mouth Cancer, Mucinous tumor, Multiple Endocrine Neoplasia Syndrome, Multiple Myeloma, Multiple myeloma, Mycosis Fungoides, Mycosis fungoides, Myelodysplastic Disease, Myelodysplastic Syndromes, Myeloid leukemia, Myeloid sarcoma, Myeloproliferative Disease, Myxoma, Nasal Cavity Cancer, Nasopharyngeal Cancer, Nasopharyngeal carcinoma, Neoplasm, Neurinoma, Neuroblastoma, Neuroblastoma, Neurofibroma, Neuroma, Nodular melanoma, Non-Hodgkin Lymphoma, Non-Hodgkin lymphoma, Nonmelanoma Skin Cancer, Non-Small Cell Lung Cancer, Ocular oncology, Oligoastrocytoma, Oligodendroglioma, Oncocytoma, Optic nerve sheath meningioma, Oral Cancer, Oral cancer, Oropharyngeal Cancer, Osteosarcoma, Osteosarcoma, Ovarian Cancer, Ovarian cancer, Ovarian Epithelial Cancer, Ovarian Germ Cell Tumor, Ovarian Low Malignant Potential Tumor, Paget's disease of the breast, Pancoast tumor, Pancreatic Cancer, Pancreatic cancer, Papillary thyroid cancer, Papillomatosis, Paraganglioma, Paranasal Sinus Cancer, Parathyroid Cancer, Penile Cancer, Perivascular epithelioid cell tumor, Pharyngeal Cancer, Pheochromocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation, Pineoblastoma, Pituicytoma, Pituitary adenoma, Pituitary tumor, Plasma Cell Neoplasm, Pleuropulmonary blastoma, Polyembryoma, Precursor T-lymphoblastic lymphoma, Primary central nervous system lymphoma, Primary effusion lymphoma, Primary Hepatocellular Cancer, Primary Liver Cancer, Primary peritoneal cancer, Primitive neuroectodermal tumor, Prostate cancer, Pseudomyxoma peritonei, Rectal Cancer, Renal cell carcinoma, Respiratory Tract Carcinoma Involving the NUT Gene on Chromosome 15, Retinoblastoma, Rhabdomyoma, Rhabdomyosarcoma, Richter's transformation, Sacrococcygeal teratoma, Salivary Gland Cancer, Sarcoma, Schwannomatosis, Sebaceous gland carcinoma, Secondary neoplasm, Seminoma, Serous tumor, Sertoli-Leydig cell tumor, Sex cord-stromal tumor, Sezary Syndrome, Signet ring cell carcinoma, Skin Cancer, Small blue round cell tumor, Small cell carcinoma, Small Cell Lung Cancer, Small cell lymphoma, Small intestine cancer, Soft tissue sarcoma, Somatostatinoma, Soot wart, Spinal Cord Tumor, Spinal tumor, Splenic marginal zone lymphoma, Squamous cell carcinoma, Stomach cancer, Superficial spreading melanoma, Supratentorial Primitive Neuroectodermal Tumor, Surface epithelial-stromal tumor, Synovial sarcoma, T-cell acute lymphoblastic leukemia, T-cell large granular lymphocyte leukemia, T-cell leukemia, T-cell lymphoma, T-cell prolymphocytic leukemia, Teratoma, Terminal lymphatic cancer, Testicular cancer, Thecoma, Throat Cancer, Thymic Carcinoma, Thymoma, Thyroid cancer, Transitional Cell Cancer of Renal Pelvis and Ureter, Transitional cell carcinoma, Urachal cancer, Urethral cancer, Urogenital neoplasm, Uterine sarcoma, Uveal melanoma, Vaginal Cancer, Verner Morrison syndrome, Verrucous carcinoma, Visual Pathway Glioma, Vulvar Cancer, Waldenstrom's macroglobulinemia, Warthin's tumor, Wilms' tumor, and combinations thereof.", "Where cancer cells are to be analyzed, primer sequences useful in any of the various operations for attaching barcode sequences and/or amplification reactions may comprise gene specific sequences which target genes or regions of genes associated with or suspected of being associated with cancer.", "For example, this can include genes or regions of genes where the presence of mutations (e.g., insertions, deletions, polymorphisms, copy number variations, and gene fusions) associated with a cancerous condition are suspected to be present in a cell population.", "As with cancer cell analysis, the analysis and diagnosis of fetal health or abnormality through the analysis of fetal cells is a difficult task using conventional techniques.", "In particular, in the absence of relatively invasive procedures, such as amniocentesis obtaining fetal cell samples can employ harvesting those cells from the maternal circulation.", "As will be appreciated, such circulating fetal cells make up an extremely small fraction of the overall cellular population of that circulation.", "As a result complex analyses are performed in order to characterize what of the obtained data is likely derived from fetal cells as opposed to maternal cells.", "By employing the single cell characterization methods and systems described herein, however, one can attribute genetic make up to individual cells, and categorize those cells as maternal or fetal based upon their respective genetic make-up.", "Further, the genetic sequence of fetal cells may be used to identify any of a number of genetic disorders, including, e.g., aneuploidy such as Down syndrome, Edwards syndrome, and Patau syndrome.", "Further, the cell surface features of fetal cells may be used to identify any of a number of disorders or diseases.", "Also of interest are immune cells.", "The methods, compositions, and systems disclosed herein can be utilized for sequence analysis of the immune repertoire, including genomic, proteomic, and cell surface features.", "Analysis of information underlying the immune repertoire can provide a significant improvement in understanding the status and function of the immune system.", "Non-limiting examples of immune cells which can be analyzed utilizing the methods described herein include B cells, T cells (e.g., cytotoxic T cells, natural killer T cells, regulatory T cells, and T helper cells), natural killer cells, cytokine induced killer (CIK) cells; myeloid cells, such as granulocytes (basophil granulocytes, eosinophil granulocytes, neutrophil granulocytes/hypersegmented neutrophils), monocytes/macrophages, mast cell, thrombocytes/megakaryocytes, and dendritic cells.", "In some embodiments, individual T cells are analyzed using the methods disclosed herein.", "In some embodiments, individual B cells are analyzed using the methods disclosed herein.", "Immune cells express various adaptive immunological receptors relating to immune function, such as T cell receptors and B cell receptors.", "T cell receptors and B cells receptors play a part in the immune response by specifically recognizing and binding to antigens and aiding in their destruction.", "The T cell receptor, or TCR, is a molecule found on the surface of T cells that is generally responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.", "The TCR is generally a heterodimer of two chains, each of which is a member of the immunoglobulin superfamily, possessing an N-terminal variable (V) domain, and a C terminal constant domain.", "In humans, in 95% of T cells the TCR consists of an alpha (α) and beta (β) chain, whereas in 5% of T cells the TCR consists of gamma and delta (γ/δ) chains.", "This ratio can change during ontogeny and in diseased states as well as in different species.", "When the TCR engages with antigenic peptide and MHC (peptide/MHC), the T lymphocyte is activated through signal transduction.", "Each of the two chains of a TCR contains multiple copies of gene segments—a variable ‘V’ gene segment, a diversity ‘D’ gene segment, and a joining T gene segment.", "The TCR alpha chain is generated by recombination of V and J segments, while the beta chain is generated by recombination of V, D, and J segments.", "Similarly, generation of the TCR gamma chain involves recombination of V and J gene segments, while generation of the TCR delta chain occurs by recombination of V, D, and J gene segments.", "The intersection of these specific regions (V and J for the alpha or gamma chain, or V, D and J for the beta or delta chain) corresponds to the CDR3 region that is important for antigen-MHC recognition.", "Complementarity determining regions (e.g., CDR1, CDR2, and CDR3), or hypervariable regions, are sequences in the variable domains of antigen receptors (e.g., T cell receptor and immunoglobulin) that can complement an antigen.", "Most of the diversity of CDRs is found in CDR3, with the diversity being generated by somatic recombination events during the development of T lymphocytes.", "A unique nucleotide sequence that arises during the gene arrangement process can be referred to as a clonotype.", "The B cell receptor, or BCR, is a molecule found on the surface of B cells.", "The antigen binding portion of a BCR is composed of a membrane-bound antibody that, like most antibodies (e.g., immunoglobulins), has a unique and randomly determined antigen-binding site.", "The antigen binding portion of a BCR includes membrane-bound immunoglobulin molecule of one isotype (e.g., IgD, IgM, IgA, IgG, or IgE).", "When a B cell is activated by its first encounter with a cognate antigen, the cell proliferates and differentiates to generate a population of antibody-secreting plasma B cells and memory B cells.", "The various immunoglobulin isotypes differ in their biological features, structure, target specificity and distribution.", "A variety of molecular mechanisms exist to generate initial diversity, including genetic recombination at multiple sites.", "The BCR is composed of two genes IgH and IgK (or IgL) coding for antibody heavy and light chains.", "Immunoglobulins are formed by recombination among gene segments, sequence diversification at the junctions of these segments, and point mutations throughout the gene.", "Each heavy chain gene contains multiple copies of three different gene segments—a variable ‘V’ gene segment, a diversity ‘D’ gene segment, and a joining T gene segment.", "Each light chain gene contains multiple copies of two different gene segments for the variable region of the protein—a variable ‘V’ gene segment and a joining T gene segment.", "The recombination can generate a molecule with one of each of the V, D, and J segments.", "Furthermore, several bases may be deleted and others added (called N and P nucleotides) at each of the two junctions, thereby generating further diversity.", "After B cell activation, a process of affinity maturation through somatic hypermutation occurs.", "In this process progeny cells of the activated B cells accumulate distinct somatic mutations throughout the gene with higher mutation concentration in the CDR regions leading to the generation of antibodies with higher affinity to the antigens.", "In addition to somatic hypermutation activated B cells undergo the process of isotype switching.", "Antibodies with the same variable segments can have different forms (isotypes) depending on the constant segment.", "Whereas all naïve B cells express IgM (or IgD), activated B cells mostly express IgG but also IgM, IgA and IgE.", "This expression switching from IgM (and/or IgD) to IgG, IgA, or IgE occurs through a recombination event causing one cell to specialize in producing a specific isotype.", "A unique nucleotide sequence that arises during the gene arrangement process can similarly be referred to as a clonotype.", "In some embodiments, the methods, compositions and systems disclosed herein are utilized to analyze the various sequences of TCRs and BCRs from immune cells, for example various clonotypes.", "In some embodiments, methods, compositions and systems disclosed herein are used to analyze the sequence of a TCR alpha chain, a TCR beta chain, a TCR delta chain, a TCR gamma chain, or any fragment thereof (e.g., variable regions including VDJ or VJ regions, constant regions, transmembrane regions, fragments thereof, combinations thereof, and combinations of fragments thereof).", "In some embodiments, methods, compositions and systems disclosed herein are used to analyze the sequence of a B cell receptor heavy chain, B cell receptor light chain, or any fragment thereof (e.g., variable regions including VDJ or VJ regions, constant regions, transmembrane regions, fragments thereof, combinations thereof, and combinations of fragments thereof).", "Where immune cells are to be analyzed, primer sequences useful in any of the various operations for attaching barcode sequences and/or amplification reactions may comprise gene specific sequences which target genes or regions of genes of immune cell proteins, for example immune receptors.", "Such gene sequences include, but are not limited to, sequences of various T cell receptor alpha variable genes (TRAV genes), T cell receptor alpha joining genes (TRAJ genes), T cell receptor alpha constant genes (TRAC genes), T cell receptor beta variable genes (TRBV genes), T cell receptor beta diversity genes (TRBD genes), T cell receptor beta joining genes (TRBJ genes), T cell receptor beta constant genes (TRBC genes), T cell receptor gamma variable genes (TRGV genes), T cell receptor gamma joining genes (TRGJ genes), T cell receptor gamma constant genes (TRGC genes), T cell receptor delta variable genes (TRDV genes), T cell receptor delta diversity genes (TRDD genes), T cell receptor delta joining genes (TRDJ genes), and T cell receptor delta constant genes (TRDC genes).", "MHCs, including full or partial MHC-peptides, may be used as labelling agents that are coupled to oligonucleotides that comprise a barcode sequence that identifies its associated MHC (and, thus, for example, the MHC's TCR binding partner).", "In some cases, MHCs are used to analyze one or more cell-surface features of a T-cell, such as a TCR.", "In some cases, multiple MHCs are associated together in a larger complex to improve binding affinity of MHCs to TCRs via multiple ligand binding synergies.", "For example, as shown in FIG.", "56A, the MHC peptides can individually be associated with biotin and bound to a streptavidin moiety such that the streptavidin moiety comprises multiple MHC moieties.", "Each of these moieties can bind to a TCR such that the streptavidin binds to the target T-cell via multiple MCH/TCR binding interactions.", "These multiple interactions synergize and can substantially improve binding affinity.", "Such improved affinity can improve labelling of T-cells and also reduce the likelihood that labels will dissociate from T-cell surfaces.", "As shown in FIG.", "56B and continuing with this example, a barcoded oligonucleotide 5601 can be modified with streptavidin 5602 and contacted with multiple molecules of biotinylated MHC 5604 such that the MHC 5604 molecules are coupled with the barcoded oligonucleotide 5601.The result is an MHC-complex 5608.As shown in FIG.", "56B, the oligonucleotide 5601 barcode sequence 5602 can identify the MHC 5604 as its associated label and also includes sequences for hybridization with other oligonucleotides (e.g., sequence 5603 comprising a ‘Spacer C C C’ and sequence 5605 comprising a ‘Spacer PCR handle’).", "One such other oligonucleotide is oligonucleotide 5611 that comprises a complementary sequence 5615 (e.g., rGrGrG corresponding to C C C), a barcode sequence 5613 and, such as, for example, a UMI 5614 as shown in FIG.", "56C.", "In some cases, oligonucleotide 5611 may at first be associated with a bead and released from the bead.", "In any case, though, oligonucleotide 5611 can hybridize with oligonucleotide 5601 the MHC-oligonucleotide complex 5608.The hybridized oligonucleotides 5611 and 5601 can then be extended in primer extension reactions such that constructs comprising sequences that correspond to each of the two barcode sequences 5613 and 5604 are generated.", "In some cases, one or both of these corresponding sequences may be a complement of the original sequence in oligonucleotide 5611 or 5601.One or both of the resulting constructs can be optionally further processed (e.g., to add any additional sequences and/or for clean-up) and subjected to sequencing.", "As described elsewhere herein, the sequence in such a construct derived from barcode sequence 5613 may be used to identify a partition or a cell within a partition and the sequence derived from barcode sequence 5604 may be used to identify the particular TCR on the surface of the cell, permitting a multi-assay analysis.", "Furthermore, while the example shown in FIG.", "56B and FIG.", "56C shows streptavidin directly coupled to its oligonucleotide, the streptavidin may also be coupled to a hybridization oligonucleotide which then hybridizes with the identifying barcoded oligonucleotide, similar to the example scheme shown in FIG.", "52B (panel II) and described elsewhere herein.", "The ability to characterize individual cells from larger diverse populations of cells is also of significant value in both environmental testing as well as in forensic analysis, where samples may, by their nature, be made up of diverse populations of cells and other material that “contaminate” the sample, relative to the cells for which the sample is being tested, e.g., environmental indicator organisms, toxic organisms, and the like for, e.g., environmental and food safety testing, victim and/or perpetrator cells in forensic analysis for sexual assault, and other violent crimes, and the like.", "Additional useful applications of the above described single cell sequencing and characterization processes are in the field of neuroscience research and diagnosis.", "In particular, neural cells can include long interspersed nuclear elements (LINEs), or ‘jumping’ genes that can move around the genome, which cause each neuron to differ from its neighbor cells.", "Research has shown that the number of LINEs in human brain exceeds that of other tissues, e.g., heart and liver tissue, with between 80 and 300 unique insertions (See, e.g., Coufal, N. G. et al.", "Nature 460, 1127-1131 (2009)).", "These differences have been postulated as being related to a person's susceptibility to neuro-logical disorders (see, e.g., Muotri, A. R. et al.", "Nature 468, 443-446 (2010)), or provide the brain with a diversity with which to respond to challenges.", "As such, the methods described herein may be used in the sequencing and characterization of individual neural cells.", "The single cell analysis methods described herein may also be useful in the analysis of gene expression, both in terms of identification of RNA transcripts and their quantitation.", "In particular, using the single cell level analysis methods described herein, one can isolate and analyze the RNA transcripts present in individual cells, populations of cells, or subsets of populations of cells.", "In particular, in some cases, the barcode oligonucleotides may be configured to prime, replicate and consequently yield barcoded fragments of RNA from individual cells.", "For example, in some cases, the barcode oligonucleotides may include mRNA specific priming sequences, e.g., poly-T primer segments that allow priming and replication of mRNA in a reverse transcription reaction or other targeted priming sequences.", "Alternatively or additionally, random RNA priming may be carried out using random N-mer primer segments of the barcode oligonucleotides.", "FIG.", "6 provides a schematic of one example method for RNA expression analysis in individual cells using the methods described herein.", "As shown, at operation 602 a cell containing sample is sorted for viable cells, which are quantified and diluted for subsequent partitioning.", "At operation 604, the individual cells separately co-partitioned with gel beads bearing the barcoding oligonucleotides as described herein.", "The cells are lysed and the barcoded oligonucleotides released into the partitions at operation 606, where they interact with and hybridize to the mRNA at operation 608, e.g., by virtue of a poly-T primer sequence, which is complementary to the poly-A tail of the mRNA.", "Using the poly-T barcode oligonucleotide as a priming sequence, a reverse transcription reaction is carried out at operation 610 to synthesize a cDNA of the mRNA that includes the barcode sequence.", "The barcoded cDNAs are then subjected to additional amplification at operation 612, e.g., using a PCR process, purification at operation 614, before they are placed on a nucleic acid sequencing system for determination of the cDNA sequence and its associated barcode sequence(s).", "In some cases, as shown, operations 602 through 608 can occur while the reagents remain in their original droplet or partition, while operations 612 through 616 can occur in bulk (e.g., outside of the partition).", "In the case where a partition is a droplet in an emulsion, the emulsion can be broken and the contents of the droplet pooled in order to complete operations 612 through 616.In some cases, barcode oligonucleotides may be digested with exonucleases after the emulsion is broken.", "Exonuclease activity can be inhibited by ethylenediaminetetraacetic acid (EDTA) following primer digestion.", "In some cases, operation 610 may be performed either within the partitions based upon co-partitioning of the reverse transcription mixture, e.g., reverse transcriptase and associated reagents, or it may be performed in bulk.", "The structure of the barcode oligonucleotides may include a number of sequence elements in addition to the oligonucleotide barcode sequence.", "One example of a barcode oligonucleotide for use in RNA analysis as described above is shown in FIG.", "7.As shown, the overall oligonucleotide 702 is coupled to a bead 704 by a releasable linkage 706, such as a disulfide linker.", "The oligonucleotide may include functional sequences that are used in subsequent processing, such as functional sequence 708, which may include one or more of a sequencer specific flow cell attachment sequence, e.g., a P5 sequence for Illumina sequencing systems, as well as sequencing primer sequences, e.g., a R1 primer for Illumina sequencing systems.", "A barcode sequence 710 is included within the structure for use in barcoding the sample RNA.", "An mRNA specific priming sequence, such as poly-T sequence 712 is also included in the oligonucleotide structure.", "An anchoring sequence segment 714 may be included to ensure that the poly-T sequence hybridizes at the sequence end of the mRNA.", "This anchoring sequence can include a random short sequence of nucleotides, e.g., 1-mer, 2-mer, 3-mer or longer sequence, which will ensure that the poly-T segment is more likely to hybridize at the sequence end of the poly-A tail of the mRNA.", "An additional sequence segment 716 may be provided within the oligonucleotide sequence.", "In some cases, this additional sequence provides a unique molecular identifier (UMI) sequence segment, e.g., as a random sequence (e.g., such as a random N-mer sequence) that varies across individual oligonucleotides coupled to a single bead, whereas barcode sequence 710 can be constant among oligonucleotides tethered to an individual bead.", "This unique sequence serves to provide a unique identifier of the starting mRNA molecule that was captured, in order to allow quantitation of the number of original expressed RNA.", "As will be appreciated, although shown as a single oligonucleotide tethered to the surface of a bead, individual bead can include tens to hundreds of thousands or millions of individual oligonucleotide molecules (e.g., at least about 10,000, 50,000, 100,000, 500,000, 1,000,000 or 10,000,000 oligonucleotide molecules), where the barcode segment can be constant or relatively constant for a given bead, but where the variable or unique sequence segment will vary across an individual bead.", "This unique molecular identifier (UMI) sequence segment may include from 5 to about 8 or more nucleotides within the sequence of the oligonucleotides.", "In some cases, the unique molecular identifier (UMI) sequence segment can be 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 nucleotides in length or longer.", "In some cases, the unique molecular identifier (UMI) sequence segment can be at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 nucleotides in length or longer.", "In some cases, the unique molecular identifier (UMI) sequence segment can be at most 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 nucleotides in length or shorter.", "In some cases, the oligonucleotide may comprise a target-specific primer.", "The target-specific primer may bind to specific sequence in a RNA molecule or a DNA molecule derived therefrom.", "For example, the specific sequence may be a sequence that is not in the poly-A tail.", "In operation, and with reference to FIGS.", "6 and 7, a cell is co-partitioned along with a barcode bearing bead and lysed while the barcoded oligonucleotides are released from the bead.", "The poly-T portion of the released barcode oligonucleotide then hybridizes to the poly-A tail of the mRNA.", "The poly-T segment then primes the reverse transcription of the mRNA to produce a cDNA of the mRNA, but which includes each of the sequence segments 708-716 of the barcode oligonucleotide.", "Again, because the oligonucleotide 702 includes an anchoring sequence 714, it will more likely hybridize to and prime reverse transcription at the sequence end of the poly-A tail of the mRNA.", "Within any given partition, all of the cDNA of the individual mRNA molecules will include a common barcode sequence segment 710.However, by including the unique random N-mer sequence, the transcripts made from different mRNA molecules within a given partition will vary at this unique sequence.", "This provides a quantitation feature that can be identifiable even following any subsequent amplification of the contents of a given partition, e.g., the number of unique segments associated with a common barcode can be indicative of the quantity of mRNA originating from a single partition, and thus, a single cell.", "The transcripts may then be amplified, cleaned up and sequenced to identify the sequence of the cDNA of the mRNA, as well as to sequence the barcode segment and the unique sequence segment.", "While a poly-T primer sequence is described, other targeted or random priming sequences may also be used in priming the reverse transcription reaction.", "Likewise, although described as releasing the barcoded oligonucleotides into the partition along with the contents of the lysed cells, it will be appreciated that in some cases, the gel bead bound oligonucleotides may be used to hybridize and capture the mRNA on the solid phase of the gel beads, in order to facilitate the separation of the RNA from other cell contents.", "An additional example of a barcode oligonucleotide for use in RNA analysis, including messenger RNA (mRNA, including mRNA obtained from a cell) analysis, is shown in FIG.", "9A.", "As shown, the overall oligonucleotide 902 can be coupled to a bead 904 by a releasable linkage 906, such as a disulfide linker.", "The oligonucleotide may include functional sequences that are used in subsequent processing, such as functional sequence 908, which may include a sequencer specific flow cell attachment sequence, e.g., a P5 sequence for Illumina sequencing systems, as well as functional sequence 910, which may include sequencing primer sequences, e.g., a R1 primer binding site for Illumina sequencing systems.", "A barcode sequence 912 is included within the structure for use in barcoding the sample RNA.", "An RNA specific (e.g., mRNA specific) priming sequence, such as poly-T sequence 914 is also included in the oligonucleotide structure.", "An anchoring sequence segment (not shown) may be included to ensure that the poly-T sequence hybridizes at the sequence end of the mRNA.", "An additional sequence segment 916 may be provided within the oligonucleotide sequence.", "This additional sequence can provide a unique molecular identifier (UMI) sequence segment, e.g., as a random N-mer sequence that varies across individual oligonucleotides coupled to a single bead, whereas barcode sequence 912 can be constant among oligonucleotides tethered to an individual bead.", "As described elsewhere herein, this unique sequence can serve to provide a unique identifier of the starting mRNA molecule that was captured, in order to allow quantitation of the number of original expressed RNA, e.g., mRNA counting.", "As will be appreciated, although shown as a single oligonucleotide tethered to the surface of a bead, individual beads can include tens to hundreds of thousands or millions of individual oligonucleotide molecules (e.g., at least about 10,000, 50,000, 100,000, 500,000, 1,000,000 or 10,000,000 oligonucleotide molecules), where the barcode segment can be constant or relatively constant for a given bead, but where the variable or unique sequence segment will vary across an individual bead.", "In an example method of cellular RNA (e.g., mRNA) analysis and in reference to FIG.", "9A, a cell is co-partitioned along with a barcode bearing bead, switch oligo 924, and other reagents such as reverse transcriptase, a reducing agent and dNTPs into a partition (e.g., a droplet in an emulsion).", "In operation 950, the cell is lysed while the barcoded oligonucleotides 902 are released from the bead (e.g., via the action of the reducing agent) and the poly-T segment 914 of the released barcode oligonucleotide then hybridizes to the poly-A tail of mRNA 920 that is released from the cell.", "Next, in operation 952 the poly-T segment 914 is extended in a reverse transcription reaction using the mRNA as a template to produce a cDNA 922 complementary to the mRNA and also includes each of the sequence segments 908, 912, 910, 916 and 914 of the barcode oligonucleotide.", "Terminal transferase activity of the reverse transcriptase can add additional bases to the cDNA (e.g., polyC).", "The switch oligo 924 may then hybridize with the additional bases added to the cDNA and facilitate template switching.", "A sequence complementary to the switch oligo sequence can then be incorporated into the cDNA 922 via extension of the cDNA 922 using the switch oligo 924 as a template.", "Within any given partition, all of the cDNAs of the individual mRNA molecules will include a common barcode sequence segment 912.However, by including the unique random N-mer sequence 916, the transcripts made from different mRNA molecules within a given partition will vary at this unique sequence.", "As described elsewhere herein, this provides a quantitation feature that can be identifiable even following any subsequent amplification of the contents of a given partition, e.g., the number of unique segments associated with a common barcode can be indicative of the quantity of mRNA originating from a single partition, and thus, a single cell.", "Following operation 952, the cDNA 922 is then amplified with primers 926 (e.g., PCR primers) in operation 954.Next, the amplified product is then purified (e.g., via solid phase reversible immobilization (SPRI)) in operation 956.At operation 958, the amplified product is then sheared, ligated to additional functional sequences, and further amplified (e.g., via PCR).", "The functional sequences may include a sequencer specific flow cell attachment sequence 930, e.g., a P7 sequence for Illumina sequencing systems, as well as functional sequence 928, which may include a sequencing primer binding site, e.g., for a R2 primer for Illumina sequencing systems, as well as functional sequence 932, which may include a sample index, e.g., an i7 sample index sequence for Illumina sequencing systems.", "In some cases, operations 950 and 952 can occur in the partition, while operations 954, 956 and 958 can occur in bulk solution (e.g., in a pooled mixture outside of the partition).", "In the case where a partition is a droplet in an emulsion, the emulsion can be broken and the contents of the droplet pooled in order to complete operations 954, 956 and 958.In some cases, operation 954 may be completed in the partition.", "In some cases, barcode oligonucleotides may be digested with exonucleases after the emulsion is broken.", "Exonuclease activity can be inhibited by ethylenediaminetetraacetic acid (EDTA) following primer digestion.", "Although described in terms of specific sequence references used for certain sequencing systems, e.g., Illumina systems, it will be understood that the reference to these sequences is for illustration purposes only, and the methods described herein may be configured for use with other sequencing systems incorporating specific priming, attachment, index, and other operational sequences used in those systems, e.g., systems available from Ion Torrent, Oxford Nanopore, Genia, Pacific Biosciences, Complete Genomics, and the like.", "In an alternative example of a barcode oligonucleotide for use in RNA (e.g., cellular RNA) analysis as shown in FIG.", "9A, functional sequence 908 may be a P7 sequence and functional sequence 910 may be a R2 primer binding site.", "Moreover, the functional sequence 930 may be a P5 sequence, functional sequence 928 may be a R1 primer binding site, and functional sequence 932 may be an i5 sample index sequence for Illumina sequencing systems.", "The configuration of the constructs generated by such a barcode oligonucleotide can help minimize (or avoid) sequencing of the poly-T sequence during sequencing.", "Shown in FIG.", "9B is another example method for RNA analysis, including cellular mRNA analysis.", "In this method, the switch oligo 924 is co-partitioned with the individual cell and barcoded bead along with reagents such as reverse transcriptase, a reducing agent and dNTPs into a partition (e.g., a droplet in an emulsion).", "The switch oligo 924 may be labeled with an additional tag 934, e.g., biotin.", "In operation 951, the cell is lysed while the barcoded oligonucleotides 902 (e.g., as shown in FIG.", "9A) are released from the bead (e.g., via the action of the reducing agent).", "In some cases, sequence 908 is a P7 sequence and sequence 910 is a R2 primer binding site.", "In other cases, sequence 908 is a P5 sequence and sequence 910 is a R1 primer binding site.", "Next, the poly-T segment 914 of the released barcode oligonucleotide hybridizes to the poly-A tail of mRNA 920 that is released from the cell.", "In operation 953, the poly-T segment 914 is then extended in a reverse transcription reaction using the mRNA as a template to produce a cDNA 922 complementary to the mRNA and also includes each of the sequence segments 908, 912, 910, 916 and 914 of the barcode oligonucleotide.", "Terminal transferase activity of the reverse transcriptase can add additional bases to the cDNA (e.g., polyC).", "The switch oligo 924 may then hybridize with the cDNA and facilitate template switching.", "A sequence complementary to the switch oligo sequence can then be incorporated into the cDNA 922 via extension of the cDNA 922 using the switch oligo 924 as a template.", "Next, an isolation operation 960 can be used to isolate the cDNA 922 from the reagents and oligonucleotides in the partition.", "The additional tag 934, e.g., biotin, can be contacted with an interacting tag 936, e.g., streptavidin, which may be attached to a magnetic bead 938.At operation 960 the cDNA can be isolated with a pull-down operation (e.g., via magnetic separation, centrifugation) before amplification (e.g., via PCR) in operation 955, followed by purification (e.g., via solid phase reversible immobilization (SPRI)) in operation 957 and further processing (shearing, ligation of sequences 928, 932 and 930 and subsequent amplification (e.g., via PCR)) in operation 959.In some cases where sequence 908 is a P7 sequence and sequence 910 is a R2 primer binding site, sequence 930 is a P5 sequence and sequence 928 is a R1 primer binding site and sequence 932 is an i5 sample index sequence.", "In some cases where sequence 908 is a P5 sequence and sequence 910 is a R1 primer binding site, sequence 930 is a P7 sequence and sequence 928 is a R2 primer binding site and sequence 932 is an i7 sample index sequence.", "In some cases, as shown, operations 951 and 953 can occur in the partition, while operations 960, 955, 957 and 959 can occur in bulk solution (e.g., in a pooled mixture outside of the partition).", "In the case where a partition is a droplet in an emulsion, the emulsion can be broken and the contents of the droplet pooled in order to complete operation 960.The operations 955, 957, and 959 can then be carried out following operation 960 after the transcripts are pooled for processing.", "Shown in FIG.", "9C is another example method for RNA analysis, including cellular mRNA analysis.", "In this method, the switch oligo 924 is co-partitioned with the individual cell and barcoded bead along with reagents such as reverse transcriptase, a reducing agent and dNTPs in a partition (e.g., a droplet in an emulsion).", "In operation 961, the cell is lysed while the barcoded oligonucleotides 902 (e.g., as shown in FIG.", "9A) are released from the bead (e.g., via the action of the reducing agent).", "In some cases, sequence 908 is a P7 sequence and sequence 910 is a R2 primer binding site.", "In other cases, sequence 908 is a P5 sequence and sequence 910 is a R1 primer binding site.", "Next, the poly-T segment 914 of the released barcode oligonucleotide then hybridizes to the poly-A tail of mRNA 920 that is released from the cell.", "Next, in operation 963 the poly-T segment 914 is then extended in a reverse transcription reaction using the mRNA as a template to produce a cDNA 922 complementary to the mRNA and also includes each of the sequence segments 908, 912, 910, 916 and 914 of the barcode oligonucleotide.", "Terminal transferase activity of the reverse transcriptase can add additional bases to the cDNA (e.g., polyC).", "The switch oligo 924 may then hybridize with the cDNA and facilitate template switching.", "A sequence complementary to the switch oligo sequence can then be incorporated into the cDNA 922 via extension of the cDNA 922 using the switch oligo 924 as a template.", "Following operation 961 and operation 963, mRNA 920 and cDNA 922 are denatured in operation 962.At operation 964, a second strand is extended from a primer 940 having an additional tag 942, e.g., biotin, and hybridized to the cDNA 922.Also in operation 964, the biotin labeled second strand can be contacted with an interacting tag 936, e.g., streptavidin, which may be attached to a magnetic bead 938.The cDNA can be isolated with a pull-down operation (e.g., via magnetic separation, centrifugation) before amplification (e.g., via polymerase chain reaction (PCR)) in operation 965, followed by purification (e.g., via solid phase reversible immobilization (SPRI)) in operation 967 and further processing (shearing, ligation of sequences 928, 932 and 930 and subsequent amplification (e.g., via PCR)) in operation 969.In some cases where sequence 908 is a P7 sequence and sequence 910 is a R2 primer binding site, sequence 930 is a P5 sequence and sequence 928 is a R1 primer binding site and sequence 932 is an i5 sample index sequence.", "In some cases where sequence 908 is a P5 sequence and sequence 910 is a R1 primer binding site, sequence 930 is a P7 sequence and sequence 928 is a R2 primer binding site and sequence 932 is an i7 sample index sequence.", "In some cases, operations 961 and 963 can occur in the partition, while operations 962, 964, 965, 967, and 969 can occur in bulk (e.g., outside the partition).", "In the case where a partition is a droplet in an emulsion, the emulsion can be broken and the contents of the droplet pooled in order to complete operations 962, 964, 965, 967 and 969.Shown in FIG.", "9D is another example method for RNA analysis, including cellular mRNA analysis.", "In this method, the switch oligo 924 is co-partitioned with the individual cell and barcoded bead along with reagents such as reverse transcriptase, a reducing agent and dNTPs.", "In operation 971, the cell is lysed while the barcoded oligonucleotides 902 (e.g., as shown in FIG.", "9A) are released from the bead (e.g., via the action of the reducing agent).", "In some cases, sequence 908 is a P7 sequence and sequence 910 is a R2 primer binding site.", "In other cases, sequence 908 is a P5 sequence and sequence 910 is a R1 primer binding site.", "Next the poly-T segment 914 of the released barcode oligonucleotide then hybridizes to the poly-A tail of mRNA 920 that is released from the cell.", "Next in operation 973, the poly-T segment 914 is then extended in a reverse transcription reaction using the mRNA as a template to produce a cDNA 922 complementary to the mRNA and also includes each of the sequence segments 908, 912, 910, 916 and 914 of the barcode oligonucleotide.", "Terminal transferase activity of the reverse transcriptase can add additional bases to the cDNA (e.g., polyC).", "The switch oligo 924 may then hybridize with the cDNA and facilitate template switching.", "A sequence complementary to the switch oligo sequence can then be incorporated into the cDNA 922 via extension of the cDNA 922 using the switch oligo 924 as a template.", "In operation 966, the mRNA 920, cDNA 922 and switch oligo 924 can be denatured, and the cDNA 922 can be hybridized with a capture oligonucleotide 944 labeled with an additional tag 946, e.g., biotin.", "In this operation, the biotin-labeled capture oligonucleotide 944, which is hybridized to the cDNA, can be contacted with an interacting tag 936, e.g., streptavidin, which may be attached to a magnetic bead 938.Following separation from other species (e.g., excess barcoded oligonucleotides) using a pull-down operation (e.g., via magnetic separation, centrifugation), the cDNA can be amplified (e.g., via PCR) with primers 926 at operation 975, followed by purification (e.g., via solid phase reversible immobilization (SPRI)) in operation 977 and further processing (shearing, ligation of sequences 928, 932 and 930 and subsequent amplification (e.g., via PCR)) in operation 979.In some cases where sequence 908 is a P7 sequence and sequence 910 is a R2 primer binding site, sequence 930 is a P5 sequence and sequence 928 is a R1 primer binding site and sequence 932 is an i5 sample index sequence.", "In other cases where sequence 908 is a P5 sequence and sequence 910 is a R1 primer binding site, sequence 930 is a P7 sequence and sequence 928 is a R2 primer binding site and sequence 932 is an i7 sample index sequence.", "In some cases, operations 971 and 973 can occur in the partition, while operations 966, 975, 977 (purification), and 979 can occur in bulk (e.g., outside the partition).", "In the case where a partition is a droplet in an emulsion, the emulsion can be broken and the contents of the droplet pooled in order to complete operations 966, 975, 977 and 979.Shown in FIG.", "9E is another example method for RNA analysis, including cellular RNA analysis.", "In this method, an individual cell is co-partitioned along with a barcode bearing bead, a switch oligo 990, and other reagents such as reverse transcriptase, a reducing agent and dNTPs into a partition (e.g., a droplet in an emulsion).", "In operation 981, the cell is lysed while the barcoded oligonucleotides (e.g., 902 as shown in FIG.", "9A) are released from the bead (e.g., via the action of the reducing agent).", "In some cases, sequence 908 is a P7 sequence and sequence 910 is a R2 primer binding site.", "In other cases, sequence 908 is a P5 sequence and sequence 910 is a R1 primer binding site.", "Next, the poly-T segment of the released barcode oligonucleotide then hybridizes to the poly-A tail of mRNA 920 released from the cell.", "Next at operation 983, the poly-T segment is then extended in a reverse transcription reaction to produce a cDNA 922 complementary to the mRNA and also includes each of the sequence segments 908, 912, 910, 916 and 914 of the barcode oligonucleotide.", "Terminal transferase activity of the reverse transcriptase can add additional bases to the cDNA (e.g., polyC).", "The switch oligo 990 may then hybridize with the cDNA and facilitate template switching.", "A sequence complementary to the switch oligo sequence and including a T7 promoter sequence, can be incorporated into the cDNA 922.At operation 968, a second strand is synthesized and at operation 970 the T7 promoter sequence can be used by T7 polymerase to produce RNA transcripts in in vitro transcription.", "At operation 985 the RNA transcripts can be purified (e.g., via solid phase reversible immobilization (SPRI)), reverse transcribed to form DNA transcripts, and a second strand can be synthesized for each of the DNA transcripts.", "In some cases, prior to purification, the RNA transcripts can be contacted with a DNase (e.g., DNAase I) to break down residual DNA.", "At operation 987 the DNA transcripts are then fragmented and ligated to additional functional sequences, such as sequences 928, 932 and 930 and, in some cases, further amplified (e.g., via PCR).", "In some cases where sequence 908 is a P7 sequence and sequence 910 is a R2 primer binding site, sequence 930 is a P5 sequence and sequence 928 is a R1 primer binding site and sequence 932 is an i5 sample index sequence.", "In some cases where sequence 908 is a P5 sequence and sequence 910 is a R1 primer binding site, sequence 930 is a P7 sequence and sequence 928 is a R2 primer binding site and sequence 932 is an i7 sample index sequence.", "In some cases, prior to removing a portion of the DNA transcripts, the DNA transcripts can be contacted with an RNase to break down residual RNA.", "In some cases, operations 981 and 983 can occur in the partition, while operations 968, 970, 985 and 987 can occur in bulk (e.g., outside the partition).", "In the case where a partition is a droplet in an emulsion, the emulsion can be broken and the contents of the droplet pooled in order to complete operations 968, 970, 985 and 987.Another example of a barcode oligonucleotide for use in RNA analysis, including messenger RNA (mRNA, including mRNA obtained from a cell) analysis is shown in FIG.", "10.As shown, the overall oligonucleotide 1002 is coupled to a bead 1004 by a releasable linkage 1006, such as a disulfide linker.", "The oligonucleotide may include functional sequences that are used in subsequent processing, such as functional sequence 1008, which may include a sequencer specific flow cell attachment sequence, e.g., a P7 sequence, as well as functional sequence 1010, which may include sequencing primer sequences, e.g., a R2 primer binding site.", "A barcode sequence 1012 is included within the structure for use in barcoding the sample RNA.", "An RNA specific (e.g., mRNA specific) priming sequence, such as poly-T sequence 1014 may be included in the oligonucleotide structure.", "An anchoring sequence segment (not shown) may be included to ensure that the poly-T sequence hybridizes at the sequence end of the mRNA.", "An additional sequence segment 1016 may be provided within the oligonucleotide sequence.", "This additional sequence can provide a unique molecular identifier (UMI) sequence segment, as described elsewhere herein.", "An additional functional sequence 1020 may be included for in vitro transcription, e.g., a T7 RNA polymerase promoter sequence.", "As will be appreciated, although shown as a single oligonucleotide tethered to the surface of a bead, individual beads can include tens to hundreds of thousands or millions of individual oligonucleotide molecules (e.g., at least about 10,000, 50,000, 100,000, 500,000, 1,000,000 or 10,000,000 oligonucleotide molecules), where the barcode segment can be constant or relatively constant for a given bead, but where the variable or unique sequence segment will vary across an individual bead.", "In an example method of cellular RNA analysis and in reference to FIG.", "10, a cell is co-partitioned along with a barcode bearing bead, and other reagents such as reverse transcriptase, reducing agent and dNTPs into a partition (e.g., a droplet in an emulsion).", "In operation 1050, the cell is lysed while the barcoded oligonucleotides 1002 are released (e.g., via the action of the reducing agent) from the bead, and the poly-T segment 1014 of the released barcode oligonucleotide then hybridizes to the poly-A tail of mRNA 1020.Next at operation 1052, the poly-T segment is then extended in a reverse transcription reaction using the mRNA as template to produce a cDNA 1022 of the mRNA and also includes each of the sequence segments 1020, 1008, 1012, 1010, 1016, and 1014 of the barcode oligonucleotide.", "Within any given partition, all of the cDNAs of the individual mRNA molecules will include a common barcode sequence segment 1012.However, by including the unique random N-mer sequence, the transcripts made from different mRNA molecules within a given partition will vary at this unique sequence.", "As described elsewhere herein, this provides a quantitation feature that can be identifiable even following any subsequent amplification of the contents of a given partition, e.g., the number of unique segments associated with a common barcode can be indicative of the quantity of mRNA originating from a single partition, and thus, a single cell.", "At operation 1054 a second strand is synthesized and at operation 1056 the T7 promoter sequence can be used by T7 polymerase to produce RNA transcripts in in vitro transcription.", "At operation 1058 the transcripts are fragmented (e.g., sheared), ligated to additional functional sequences, and reverse transcribed.", "The functional sequences may include a sequencer specific flow cell attachment sequence 1030, e.g., a P5 sequence, as well as functional sequence 1028, which may include sequencing primers, e.g., a R1 primer binding sequence, as well as functional sequence 1032, which may include a sample index, e.g., an i5 sample index sequence.", "At operation 1060 the RNA transcripts can be reverse transcribed to DNA, the DNA amplified (e.g., via PCR), and sequenced to identify the sequence of the cDNA of the mRNA, as well as to sequence the barcode segment and the unique sequence segment.", "In some cases, operations 1050 and 1052 can occur in the partition, while operations 1054, 1056, 1058 and 1060 can occur in bulk (e.g., outside the partition).", "In the case where a partition is a droplet in an emulsion, the emulsion can be broken and the contents of the droplet pooled in order to complete operations 1054, 1056, 1058 and 1060.In an alternative example of a barcode oligonucleotide for use in RNA (e.g., cellular RNA) analysis as shown in FIG.", "10, functional sequence 1008 may be a P5 sequence and functional sequence 1010 may be a R1 primer binding site.", "Moreover, the functional sequence 1030 may be a P7 sequence, functional sequence 1028 may be a R2 primer binding site, and functional sequence 1032 may be an i7 sample index sequence.", "An additional example of a barcode oligonucleotide for use in RNA analysis, including messenger RNA (mRNA, including mRNA obtained from a cell) analysis is shown in FIG.", "11.As shown, the overall oligonucleotide 1102 is coupled to a bead 1104 by a releasable linkage 1106, such as a disulfide linker.", "The oligonucleotide may include functional sequences that are used in subsequent processing, such as functional sequence 1108, which may include a sequencer specific flow cell attachment sequence, e.g., a P5 sequence, as well as functional sequence 1110, which may include sequencing primer sequences, e.g., a R1 primer binding site.", "In some cases, sequence 1108 is a P7 sequence and sequence 1110 is a R2 primer binding site.", "A barcode sequence 1112 is included within the structure for use in barcoding the sample RNA.", "An additional sequence segment 1116 may be provided within the oligonucleotide sequence.", "In some cases, this additional sequence can provide a unique molecular identifier (UMI) sequence segment, as described elsewhere herein.", "An additional sequence 1114 may be included to facilitate template switching, e.g., polyG.", "As will be appreciated, although shown as a single oligonucleotide tethered to the surface of a bead, individual beads can include tens to hundreds of thousands or millions of individual oligonucleotide molecules (e.g., at least about 10,000, 50,000, 100,000, 500,000, 1,000,000 or 10,000,000 oligonucleotide molecules), where the barcode segment can be constant or relatively constant for a given bead, but where the variable or unique sequence segment will vary across an individual bead.", "In an example method of cellular mRNA analysis and in reference to FIG.", "11, a cell is co-partitioned along with a microcapsule (e.g., bead bearing a barcoded oligonucleotide), polyT sequence, and other reagents such as a DNA polymerase, a reverse transcriptase, oligonucleotide primers, dNTPs, and reducing agent into a partition (e.g., a droplet in an emulsion).", "The partition can serve as a reaction volume.", "As described elsewhere herein, the partition serving as the reaction volume can comprise a container or vessel such as a well, a microwell, vial, a tube, through ports in nanoarray substrates, or micro-vesicles having an outer barrier surrounding an inner fluid center or core, emulsion, or a droplet.", "In some embodiments, the partition comprises a droplet of aqueous fluid within a non-aqueous continuous phase, e.g., an oil phase.", "Within the partition, the cell can be lysed and the barcoded oligonucleotides can be released from the bead (e.g., via the action of the reducing agent or other stimulus).", "Cell lysis and release of the barcoded oligonucleotides from the microcapsule may occur simultaneously in the partition (e.g., a droplet in an emulsion) or the reaction volume.", "In some embodiments, cell lysis precedes release of the barcoded oligonucleotides from the microcapsule.", "In some embodiments, release of the barcoded oligonucleotides from the microcapsule precedes cell lysis.", "Subsequent to cell lysis and the release of barcoded oligonucleotides from the microcapsule, the reaction volume can be subjected to an amplification reaction to generate an amplification product.", "In an example amplification reaction, the polyT sequence hybridizes to the polyA tail of mRNA 1120 released from the cell as illustrated in operation 1150.Next, in operation 1152, the polyT sequence is then extended in a reverse transcription reaction using the mRNA as a template to produce a cDNA 1122 complementary to the mRNA.", "Terminal transferase activity of the reverse transcriptase can add additional bases to the cDNA (e.g., polyC) in a template independent manner.", "The additional bases added to the cDNA, e.g., polyC, can then hybridize with 1114 of the barcoded oligonucleotide.", "This can facilitate template switching and a sequence complementary to the barcoded oligonucleotide can be incorporated into the cDNA.", "In various embodiments, the barcoded oligonucleotide does not hybridize to the template polynucleotide.", "The barcoded oligonucleotide, upon release from the microcapsule, can be present in the reaction volume at any suitable concentration.", "In some embodiments, the barcoded oligonucleotide is present in the reaction volume at a concentration of about 0.2 μM, 0.3 μM, 0.4 μM, 0.5 μM, 1 μM, 5 μM, 10 μM, 15 μM, 20 μM, 25 μM, 30 μM, 35 μM, 40 μM, 50 μM, 100 μM, 150 μM, 200 μM, 250 μM, 300 μM, 400 μM, or 500 μM.", "In some embodiments, the barcoded oligonucleotide is present in the reaction volume at a concentration of at least about 0.2 μM, 0.3 μM, 0.4 μM, 0.5 μM, 1 μM, 5 μM, 10 μM, 15 μM, 20 μM, 25 μM, 30 μM, 35 μM, 40 μM, 50 μM, 100 μM, 150 μM, 200 μM, 250 μM, 300 μM, 400 μM, 500 μM or greater.", "In some embodiments, the barcoded oligonucleotide is present in the reaction volume at a concentration of at most about 0.2 μM, 0.3 μM, 0.4 μM, 0.5 μM, 1 μM, 5 μM, 10 μM, 15 μM, 20 μM, 25 μM, 30 μM, 35 μM, 40 μM, 50 μM, 100 μM, 150 μM, 200 μM, 250 μM, 300 μM, 400 μM, or 500 μM.", "The transcripts can be further processed (e.g., amplified, portions removed, additional sequences added, etc.)", "and characterized as described elsewhere herein.", "In some embodiments, the transcripts are sequenced directly.", "In some embodiments, the transcripts are further processed (e.g., portions removed, additional sequences added, etc) and then sequenced.", "In some embodiments, the reaction volume is subjected to a second amplification reaction to generate an additional amplification product.", "The transcripts or first amplification products can be used as the template for the second amplification reaction.", "In some embodiments, primers for the second amplification reaction comprise the barcoded oligonucleotide and polyT sequence.", "In some embodiments, primers for the second amplification reaction comprise additional primers co-partitioned with the cell.", "In some embodiments, these additional amplification products are sequenced directly.", "In some embodiments, these additional amplification products are further processed (e.g., portions removed, additional sequences added, etc) and then sequenced.", "The configuration of the amplification products (e.g., first amplification products and second amplification products) generated by such a method can help minimize (or avoid) sequencing of the poly-T sequence during sequencing.", "An additional example of a barcode oligonucleotide for use in RNA analysis, including cellular RNA analysis is shown in FIG.", "12A.", "As shown, the overall oligonucleotide 1202 is coupled to a bead 1204 by a releasable linkage 1206, such as a disulfide linker.", "The oligonucleotide may include functional sequences that are used in subsequent processing, such as functional sequence 1208, which may include a sequencer specific flow cell attachment sequence, e.g., a P5 sequence, as well as functional sequence 1210, which may include sequencing primer sequences, e.g., a R1 primer binding site.", "In some cases, sequence 1208 is a P7 sequence and sequence 1210 is a R2 primer binding site.", "A barcode sequence 1212 is included within the structure for use in barcoding the sample RNA.", "An additional sequence segment 1216 may be provided within the oligonucleotide sequence.", "In some cases, this additional sequence can provide a unique molecular identifier (UMI) sequence segment, as described elsewhere herein.", "As will be appreciated, although shown as a single oligonucleotide tethered to the surface of a bead, individual beads can include tens to hundreds of thousands or millions of individual oligonucleotide molecules (e.g., at least about 10,000, 50,000, 100,000, 500,000, 1,000,000 or 10,000,000 oligonucleotide molecules), where the barcode segment can be constant or relatively constant for a given bead, but where the variable or unique sequence segment will vary across an individual bead.", "In an example method of cellular RNA analysis using this barcode, a cell is co-partitioned along with a barcode bearing bead and other reagents such as RNA ligase and a reducing agent into a partition (e.g., a droplet in an emulsion).", "The cell is lysed while the barcoded oligonucleotides are released (e.g., via the action of the reducing agent) from the bead.", "The barcoded oligonucleotides can then be ligated to the 5′ end of mRNA transcripts while in the partitions by RNA ligase.", "Subsequent operations may include purification (e.g., via solid phase reversible immobilization (SPRI)) and further processing (shearing, ligation of functional sequences, and subsequent amplification (e.g., via PCR)), and these operations may occur in bulk (e.g., outside the partition).", "In the case where a partition is a droplet in an emulsion, the emulsion can be broken and the contents of the droplet pooled for the additional operations.", "An additional example of a barcode oligonucleotide for use in RNA analysis, including cellular RNA analysis is shown in FIG.", "12B.", "As shown, the overall oligonucleotide 1222 is coupled to a bead 1224 by a releasable linkage 1226, such as a disulfide linker.", "The oligonucleotide may include functional sequences that are used in subsequent processing, such as functional sequence 1228, which may include a sequencer specific flow cell attachment sequence, e.g., a P5 sequence, as well as functional sequence 1230, which may include sequencing primer sequences, e.g., a R1 primer binding site.", "In some cases, sequence 1228 is a P7 sequence and sequence 1230 is a R2 primer binding site.", "A barcode sequence 1232 is included within the structure for use in barcoding the sample RNA.", "A priming sequence 1234 (e.g., a random priming sequence) can also be included in the oligonucleotide structure, e.g., a random hexamer.", "An additional sequence segment 1236 may be provided within the oligonucleotide sequence.", "In some cases, this additional sequence provides a unique molecular identifier (UMI) sequence segment, as described elsewhere herein.", "As will be appreciated, although shown as a single oligonucleotide tethered to the surface of a bead, individual beads can include tens to hundreds of thousands or millions of individual oligonucleotide molecules (e.g., at least about 10,000, 50,000, 100,000, 500,000, 1,000,000 or 10,000,000 oligonucleotide molecules), where the barcode segment can be constant or relatively constant for a given bead, but where the variable or unique sequence segment will vary across an individual bead.", "In an example method of cellular mRNA analysis using the barcode oligonucleotide of FIG.", "12B, a cell is co-partitioned along with a barcode bearing bead and additional reagents such as reverse transcriptase, a reducing agent and dNTPs into a partition (e.g., a droplet in an emulsion).", "The cell is lysed while the barcoded oligonucleotides are released from the bead (e.g., via the action of the reducing agent).", "In some cases, sequence 1228 is a P7 sequence and sequence 1230 is a R2 primer binding site.", "In other cases, sequence 1228 is a P5 sequence and sequence 1230 is a R1 primer binding site.", "The priming sequence 1234 of random hexamers can randomly hybridize cellular mRNA.", "The random hexamer sequence can then be extended in a reverse transcription reaction using mRNA from the cell as a template to produce a cDNA complementary to the mRNA and also includes each of the sequence segments 1228, 1232, 1230, 1236, and 1234 of the barcode oligonucleotide.", "Subsequent operations may include purification (e.g., via solid phase reversible immobilization (SPRI)), further processing (shearing, ligation of functional sequences, and subsequent amplification (e.g., via PCR)), and these operations may occur in bulk (e.g., outside the partition).", "In the case where a partition is a droplet in an emulsion, the emulsion can be broken and the contents of the droplet pooled for additional operations.", "Additional reagents that may be co-partitioned along with the barcode bearing bead may include oligonucleotides to block ribosomal RNA (rRNA) and nucleases to digest genomic DNA and cDNA from cells.", "Alternatively, rRNA removal agents may be applied during additional processing operations.", "The configuration of the constructs generated by such a method can help minimize (or avoid) sequencing of the poly-T sequence during sequencing.", "The single cell analysis methods described herein may also be useful in the analysis of the whole transcriptome.", "Referring back to the barcode of FIG.", "12B, the priming sequence 1234 may be a random N-mer.", "In some cases, sequence 1228 is a P7 sequence and sequence 1230 is a R2 primer binding site.", "In other cases, sequence 1228 is a P5 sequence and sequence 1230 is a R1 primer binding site.", "In an example method of whole transcriptome analysis using this barcode, the individual cell is co-partitioned along with a barcode bearing bead, poly-T sequence, and other reagents such as reverse transcriptase, polymerase, a reducing agent and dNTPs into a partition (e.g., droplet in an emulsion).", "In an operation of this method, the cell is lysed while the barcoded oligonucleotides are released from the bead (e.g., via the action of the reducing agent) and the poly-T sequence hybridizes to the poly-A tail of cellular mRNA.", "In a reverse transcription reaction using the mRNA as template, cDNAs of cellular mRNA can be produced.", "The RNA can then be degraded with an RNase.", "The priming sequence 1234 in the barcoded oligonucleotide can then randomly hybridize to the cDNAs.", "The oligonucleotides can be extended using polymerase enzymes and other extension reagents co-partitioned with the bead and cell similar to as shown in FIG.", "3 to generate amplification products (e.g., barcoded fragments), similar to the example amplification product shown in FIG.", "3 (panel F).", "The barcoded nucleic acid fragments may, in some cases subjected to further processing (e.g., amplification, addition of additional sequences, clean up processes, etc.", "as described elsewhere herein) characterized, e.g., through sequence analysis.", "In this operation, sequencing signals can come from full length RNA.", "In an example method, the barcode sequence can be appended to the 3′ end of the template polynucleotide sequence (e.g., mRNA).", "Such configuration may be useful, for example, if the sequence the 3′ end of the template polynucleotide is to be analyzed.", "In some embodiments, the barcode sequence can be appended to the 5′ end of a template polynucleotide sequence (e.g., mRNA).", "Such configuration may be useful, for example, if the sequence at the 5′ end of the template polynucleotide is to be analyzed.", "In another aspect, a partition comprises a cell co-partitioned with a primer having a sequence towards a 3′ end that hybridizes to the template polynucleotide, a template switching oligonucleotide having a first predefined sequence towards a 5′ end, and a microcapsule, such as a bead, having barcoded oligonucleotides releasably coupled thereto.", "In some embodiments, the oligonucleotides coupled to the bead include barcode sequences that are identical (e.g., all oligonucleotides sharing the same barcode sequence).", "In some aspects, the oligonucleotides coupled to the beads additionally include unique molecular identifier (UMI) sequence segments (e.g., all oligonucleotides having different unique molecular identifier sequences).", "FIG.", "18 shows a barcoded oligonucleotide coupled to a bead.", "As shown, the overall oligonucleotide 1802 is coupled to a bead 1804 by a releasable linkage 1806, such as a disulfide linker.", "The oligonucleotide may include functional sequences that are useful for subsequent processing, such as functional sequence 1808, which may include a sequencer specific flow cell attachment sequence, e.g., a P5 sequence, as well as functional sequence 1810, which may include sequencing primer sequences, e.g., a R1 primer binding site.", "In some cases, sequence 1808 is a P7 sequence and sequence 1810 is a R2 primer binding site.", "A barcode sequence 1812 can be included within the structure for use in barcoding the template polynucleotide.", "The functional sequences may be selected for compatibility with a variety of different sequencing systems, e.g., 454 Sequencing, Ion Torrent Proton or PGM, Illumina X10, etc., and the requirements thereof.", "In some cases, the barcode sequence 1812, functional sequences 1808 (e.g., flow cell attachment sequence) and 1810 (e.g., sequencing primer sequences) may be common to all of the oligonucleotides attached to a given bead.", "The barcoded oligonucleotide can also comprise a sequence 1816 to facilitate template switching (e.g., a polyG sequence).", "In some cases, the additional sequence provides a unique molecular identifier (UMI) sequence segment, as described elsewhere herein.", "Although shown as a single oligonucleotide tethered to the surface of a bead, individual beads can include tens to hundreds of thousands or millions of individual oligonucleotide molecules (e.g., at least about 10,000, 50,000, 100,000, 500,000, 1,000,000 or 10,000,000 oligonucleotide molecules), where the barcode sequence can be constant or relatively constant for a given bead.", "In an example method of cellular polynucleotide analysis using the barcode oligonucleotide of FIG.", "18, a cell is co-partitioned along with a bead bearing a barcoded oligonucleotide and additional reagents such as reverse transcriptase, primers, oligonucleotides (e.g., template switching oligonucleotides), dNTPs, and reducing agent into a partition (e.g., a droplet in an emulsion).", "Within the partition, the cell can be lysed to yield a plurality of template polynucleotides (e.g., DNA such as genomic DNA, RNA such as mRNA, etc).", "In some cases, the cell is lysed using lysis reagents that are co-partitioned with the cell.", "Where the bead is a degradable or disruptable bead, the barcoded oligonucleotide can be released from the bead following the application of stimulus as previously described.", "Following release from the bead, the barcoded oligonucleotide can be present in the partition at any suitable concentration.", "In some embodiments, the barcoded oligonucleotide is present in the partition at a concentration that is suitable for generating a sufficient yield of amplification products for downstream processing and analysis, including, but not limited to, sequencing adaptor attachment and sequencing analysis.", "In some embodiments, the concentration of the barcoded oligonucleotide is limited by the loading capacity of the barcode bearing bead, or the amount of oligonucleotides deliverable by the bead.", "The template switching oligonucleotide, which can be co-partitioned with the cell, bead bearing barcoded oligonucleotides, etc, can be present in the partition at any suitable concentration.", "In some embodiments, the template switching oligonucleotide is present in the partition at a concentration that is suitable for efficient template switching during an amplification reaction.", "The concentration of the template switching oligonucleotide can be dependent on the reagents used for droplet generation.", "In some embodiments, the template switching oligonucleotide is among a plurality of template switching oligonucleotides.", "In some embodiments, the barcoded oligonucleotide and template switching oligonucleotide are present in the partition at similar concentrations.", "In some embodiments, the barcoded oligonucleotide and template switching oligonucleotides may be present in proportions reflective of the amount of amplification products to be generated using each oligonucleotide.", "In some embodiments, the template switching oligonucleotide is present in the partition at a greater concentration than the barcoded oligonucleotide.", "This difference in concentration can be due to limitations on the capacity of the barcode bearing bead.", "In some embodiments, the concentration of the template switching oligonucleotide in the reaction volume is at least 2, 5, 10, 20, 50, 100, or 200 times that of the concentration of the barcoded oligonucleotide in the same reaction volume when the barcoded oligonucleotide is free in the partition (e.g., not attached to the bead).", "As illustrated in FIG.", "19, a reaction mixture comprising a template polynucleotide from a cell 1920 and (i) the primer 1924 having a sequence towards a 3′ end that hybridizes to the template polynucleotide (e.g., polyT) and (ii) a template switching oligonucleotide 1926 that comprises a first predefined sequence 1810 towards a 5′ end can be subjected to an amplification reaction to yield a first amplification product.", "In some cases, the template polynucleotide is an mRNA with a polyA tail and the primer that hybridizes to the template polynucleotide comprises a polyT sequence towards a 3′ end, which is complementary to the polyA segment.", "The first predefined sequence can comprise at least one of an adaptor sequence, a barcode sequence, a unique molecular identifier (UMI) sequence, a primer binding site, and a sequencing primer binding site or any combination thereof.", "In some cases, the first predefined sequence 1810 is a sequence that can be common to all partitions of a plurality of partitions.", "For example, the first predefined sequence may comprise a flow cell attachment sequence, an amplification primer binding site, or a sequencing primer binding site and the first amplification reaction facilitates the attachment the predefined sequence to the template polynucleotide from the cell.", "In some embodiments, the first predefined sequence comprises a primer binding site.", "In some embodiments, the first predefined sequence comprises a sequencing primer binding site.", "As illustrated in operation 1950, the sequence towards a 3′ end (e.g., polyT) of the primer 1924 hybridizes to the template polynucleotide 1920.In a first amplification reaction, extension reaction reagents, e.g., reverse transcriptase, nucleoside triphosphates, co-factors (e.g., Mg2+ or Mn2+), that are also co-partitioned, can extend the primer 1924 sequence using the cell's nucleic acid as a template, to produce a transcript, e.g., cDNA, 1922 having a fragment complementary to the strand of the cell's nucleic acid to which the primer annealed.", "In some cases, the reverse transcriptase has terminal transferase activity and the reverse transcriptase adds additional nucleotides, e.g., polyC, to the cDNA in a template independent manner.", "As illustrated in operation 1952, the template switching oligonucleotide 1926, for example a template switching oligonucleotide which includes a polyG sequence, can hybridize to the cDNA 1922 and facilitate template switching in the first amplification reaction.", "The transcript, therefore, may comprise the sequence of the primer 1924, a sequence complementary to the template polynucleotide from the cell, and a sequence complementary to the template switching oligonucleotide.", "Among a plurality of partitions, each partition containing one or more cells or no cells, the primer and template switching oligonucleotide may be universal to all partitions.", "Where analysis of mRNA is conducted, for example, the primer may comprise at least a polyT segment capable of hybridizing and priming an extension reaction from the polyA segment of an mRNA.", "Where analysis of a variety of polynucleotides is conducted, the primer may comprise a random sequence capable of hybridizing to and priming extension reactions randomly on various polynucleotide templates.", "As template switching can occur with the use of an enzyme having terminal transferase activity, a template switching oligonucleotide having a sequence capable of hybridizing to the appended bases can be used for template switching in manner that is independent of the sequence of the polynucleotide templates to be analyzed.", "In some embodiments, the template switching oligonucleotide can comprise a first predefined sequence towards a 5′ end that does not specifically hybridize to the template.", "In some embodiments, analysis of particular genes is conducted.", "In such cases, the primer may comprise a gene specific sequence capable of hybridizing to and priming extension reactions from templates comprising specific genes.", "In some embodiments, multiple genes are analyzed and a primer is among a plurality of primers.", "Each of the plurality of primers may have a sequence for a particular gene of interest.", "Subsequent to the first amplification reaction, the first amplification product or transcript can be subjected to a second amplification reaction to generate a second amplification product.", "In some cases, additional sequences (e.g., functional sequences such as flow cell attachment sequence, sequencing primer binding sequences, barcode sequences, etc) are to be attached.", "The first and second amplification reactions can be performed in the same volume, such as for example in a droplet.", "In some cases, the first amplification product is subjected to a second amplification reaction in the presence of a barcoded oligonucleotide to generate a second amplification product having a barcode sequence.", "The barcode sequence can be unique to a partition, that is, each partition has a unique barcode sequence.", "The barcoded oligonucleotide may comprise a sequence of at least a segment of the template switching oligonucleotide and at least a second predefined sequence.", "The segment of the template switching oligonucleotide on the barcoded oligonucleotide can facilitate hybridization of the barcoded oligonucleotide to the transcript, e.g., cDNA, to facilitate the generation of a second amplification product.", "In addition to a barcode sequence, the barcoded oligonucleotide may comprise a second defined sequence such as at least one of an adaptor sequence, a unique molecular identifier (UMI) sequence, a primer binding site, and a sequencing primer binding site or any combination thereof.", "In some embodiments, the second amplification reaction uses the first amplification product as a template and the barcoded oligonucleotide as a primer.", "As illustrated in operation 1954, the segment of the template switching oligonucleotide on the barcoded oligonucleotide 1928 can hybridize to the portion of the cDNA or complementary fragment 1922 having a sequence complementary to the template switching oligonucleotide or that which was copied from the template switching oligonucleotide.", "In the second amplification reaction, extension reaction reagents, e.g., polymerase, nucleoside triphosphates, co-factors (e.g., Mg2+ or Mn2+), that are also co-partitioned, can extend the primer sequence using the first amplification product as template as illustrated in operation 1956.The second amplification product can comprise a second predefined sequence (e.g., 1808, 1812, and 1810), a sequence of a segment of the template polynucleotide (e.g., mRNA), and a sequence complementary to the primer (e.g., 1924).", "In some embodiments, the second amplification product uses the barcoded oligonucleotide as a template and at least a portion of the first amplification product as a primer.", "As illustrated in operation 1954, the segment of the first amplification product (e.g., cDNA) having a sequence complementary to the template switching oligonucleotide can hybridize to the segment of the barcoded oligonucleotide comprising a sequence of at least a segment of the template switching oligonucleotide.", "In the second amplification reaction, extension reaction reagents, e.g., polymerase, nucleoside triphosphates, co-factors (e.g., Mg2+ or Mn2+), that are also co-partitioned, can extend the primer sequence (e.g., first amplification product) using the barcoded oligonucleotide as template as illustrated in operation 1958.The second amplification product may comprise the sequence of the primer (e.g., 1924), a sequence which is complementary to the sequence of the template polynucleotide (e.g., mRNA), and a sequence complementary to the second predefined sequence (e.g., 1808, 1812, and 1810).", "In some embodiments, the second amplification reaction is performed subsequent to the first amplification reaction in the presence of an intervening purification operation.", "An intervening purification operation can be used, for example, to purify the template (e.g., first amplification product) from excess reagents, including excess primers such as template switching oligonucleotides.", "In some embodiments, the amplification reaction is performed in the absence of an intervening purification operation.", "In certain embodiments, an intervening purification operation is not performed so that all sample preparation is performed in a same reaction volume.", "In the absence of an intervening purification operation, the template switching oligonucleotide may compete with barcoded oligonucleotide in the second amplification reaction as the barcoded oligonucleotide comprises at least a segment of the template switching oligonucleotide.", "Competition between the template switching oligonucleotide and barcoded oligonucleotide in the second amplification reaction to generate additional amplification product may result in a second amplification product lacking a barcode sequence.", "In some embodiments, the template switching oligonucleotide may out-compete the barcoded oligonucleotide in the second amplification reaction if the template switching oligonucleotide is present at a higher concentration in the reaction volume than the barcoded oligonucleotide.", "Various approaches can be utilized to favor the use of the barcoded oligonucleotide in the second amplification reaction to generate amplification products having a barcode sequence in situations where the barcoded oligonucleotide is present at a lower concentration than the template switching oligonucleotide in the reaction volume.", "In some embodiments, the template switching oligonucleotide is not available for primer extension during the second amplification reaction.", "In some embodiments, the template switching oligonucleotide is degraded prior to the second amplification reaction.", "In some embodiments, the template switching oligonucleotide is degraded during the second amplification reaction.", "The template switching oligonucleotide may comprise ribonucleic acids (RNA).", "A template switching oligonucleotide comprising RNA can be degraded, for example, by elevated temperatures or alkaline conditions.", "In some embodiments, the template switching oligonucleotide comprises at least 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, or 95% RNA.", "In some embodiments, the template switching oligonucleotide comprises 100% RNA.", "In some embodiments, a first reaction rate of the second amplification reaction using the barcoded oligonucleotide is greater than a second reaction rate of the second amplification using the template switching oligonucleotide.", "In some embodiments, the barcoded oligonucleotide can hybridize to the first amplification product at a higher annealing temperature as compared to the template switching oligonucleotide.", "For example, the first amplification product and the barcoded oligonucleotide can have a higher melting temperature as compared to a melting temperature of the first amplification product and the template switching oligonucleotide.", "In such cases, the second amplification reaction may be performed with an annealing temperature at which the barcoded oligonucleotide is able to hybridize to the first amplification product and initiation primer extension and at which the template switching oligonucleotide is unable to hybridize to the first amplification product and initiate primer extension.", "In some embodiments, the primer annealing temperature of the second amplification reaction is at least about 0.5° C., 1° C., 2° C., 3° C., 4° C., 5° C., 6° C., 7° C., 8° C., 9° C., 10° C. or greater than a primer annealing temperature of the first amplification reaction.", "The difference in melting temperatures can result from the presence of modified nucleotides in the template switching oligonucleotide.", "In some embodiment, the template switching oligonucleotide comprises at least about 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, or 95% modified nucleotides.", "In some embodiments, the template switching oligonucleotide comprises 100% modified oligonucleotides.", "In some embodiments, the difference in melting temperature can be the result of the presence of modified nucleotides in the barcoded oligonucleotide.", "In some embodiment, the barcoded oligonucleotide comprises at least 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, or 95% modified nucleotides.", "In some embodiments, the barcoded oligonucleotide comprises 100% modified oligonucleotides.", "Modified nucleotides include, but are not limited to, 2-Aminopurine, 2,6-Diaminopurine (2-Amino-dA), inverted dT, 5-Methyl dC, 2′-deoxylnosine, Super T (5-hydroxybutynl-2′-deoxyuridine), Super G (8-aza-7-deazaguanosine), locked nucleic acids (LNAs), unlocked nucleic acids (UNAs, e.g., UNA-A, UNA-U, UNA-C, UNA-G), Iso-dG, Iso-dC, and 2′ Fluoro bases (e.g., Fluoro C, Fluoro U, Fluoro A, and Fluoro G).", "In various embodiments, the first amplification reaction is facilitated using an enzyme comprising polymerase activity.", "For example, the first amplification reaction can be facilitated by a DNA-dependent polymerase or a reverse-transcriptase (e.g., RNA dependent).", "In some embodiments, the first amplification reaction comprises polymerase chain reaction.", "In some embodiments, the first amplification reaction comprises reverse transcription.", "In various embodiments, the second amplification reaction is facilitated using an enzyme comprising polymerase activity.", "For example, the second amplification reaction can be facilitated by a DNA-dependent polymerase.", "In some embodiments, the second amplification reaction comprises polymerase chain reaction.", "Following the generation of amplification products, subsequent operations may include purification (e.g., via solid phase reversible immobilization (SPRI)), further processing (e.g., shearing, ligation of functional sequences, and subsequent amplification (e.g., via PCR)).", "These operations may occur in bulk (e.g., outside the partition).", "In the case where a partition is a droplet in an emulsion, the emulsion can be broken and the contents of the droplet pooled for additional operations.", "Additional reagents that may be co-partitioned along with the barcode bearing bead may include oligonucleotides to block ribosomal RNA (rRNA) and nucleases to digest genomic DNA from cells.", "Alternatively, rRNA removal agents may be applied during additional processing operations.", "The configuration of the constructs generated by such a method can help minimize (or avoid) sequencing of the poly-T sequence during sequencing and/or sequence the 5′ end of a polynucleotide sequence.", "The amplification products, for example first amplification products and/or second amplification products, may be subject to sequencing for sequence analysis.", "Although operations with various barcode designs have been discussed individually, individual beads can include barcode oligonucleotides of various designs for simultaneous use.", "In addition to characterizing individual cells or cell sub-populations from larger populations, the processes and systems described herein may also be used to characterize individual cells as a way to provide an overall profile of a cellular, or other organismal population.", "A variety of applications require the evaluation of the presence and quantification of different cell or organism types within a population of cells, including, for example, microbiome analysis and characterization, environmental testing, food safety testing, epidemiological analysis, e.g., in tracing contamination or the like.", "In particular, the analysis processes described above may be used to individually characterize, sequence and/or identify large numbers of individual cells within a population.", "This characterization may then be used to assemble an overall profile of the originating population, which can provide important prognostic and diagnostic information.", "For example, shifts in human microbiomes, including, e.g., gut, buccal, epidermal microbiomes, etc., have been identified as being both diagnostic and prognostic of different conditions or general states of health.", "Using the single cell analysis methods and systems described herein, one can again, characterize, sequence and identify individual cells in an overall population, and identify shifts within that population that may be indicative of diagnostic ally relevant factors.", "By way of example, sequencing of bacterial 16S ribosomal RNA genes has been used as a highly accurate method for taxonomic classification of bacteria.", "Using the targeted amplification and sequencing processes described above can provide identification of individual cells within a population of cells.", "One may further quantify the numbers of different cells within a population to identify current states or shifts in states over time.", "See, e.g., Morgan et al, PLoS Comput.", "Biol., Ch.", "12, December 2012, 8(12):e1002808, and Ram et al., Syst.", "Biol.", "Reprod.", "Med., June 2011, 57(3):162-170, each of which is entirely incorporated herein by reference for all purposes.", "Likewise, identification and diagnosis of infection or potential infection may also benefit from the single cell analyses described herein, e.g., to identify microbial species present in large mixes of other cells or other biological material, cells and/or nucleic acids, including the environments described above, as well as any other diagnostically relevant environments, e.g., cerebrospinal fluid, blood, fecal or intestinal samples, or the like.", "The foregoing analyses may also be particularly useful in the characterization of potential drug resistance of different cells or pathogens, e.g., cancer cells, bacterial pathogens, etc., through the analysis of distribution and profiling of different resistance markers/mutations across cell populations in a given sample.", "Additionally, characterization of shifts in these markers/mutations across populations of cells over time can provide valuable insight into the progression, alteration, prevention, and treatment of a variety of diseases characterized by such drug resistance issues.", "Although described in terms of cells, it will be appreciated that any of a variety of individual biological organisms, or components of organisms are encompassed within this description, including, for example, cells, viruses, organelles, cellular inclusions, vesicles, or the like.", "Additionally, where referring to cells, it will be appreciated that such reference includes any type of cell, including without limitation prokaryotic cells, eukaryotic cells, bacterial, fungal, plant, mammalian, or other animal cell types, mycoplasmas, normal tissue cells, tumor cells, or any other cell type, whether derived from single cell or multicellular organisms.", "Similarly, analysis of different environmental samples to profile the microbial organisms, viruses, or other biological contaminants that are present within such samples, can provide important information about disease epidemiology, and potentially aid in forecasting disease outbreaks, epidemics an pandemics.", "As described above, the methods, systems and compositions described herein may also be used for analysis and characterization of other aspects of individual cells or populations of cells.", "A method 2000 for characterizing a cell is shown in FIG.", "20.The method 2000 may comprise, as shown in operation 2010, providing a partition comprising a cell and at least one labelling agent, all as described herein.", "The labelling agent may be capable of binding to a cell surface feature of the cell, and may be coupled to a reporter oligonucleotide comprising a nucleic acid barcode sequence that permits identification of the labelling agent.", "Further, the partition may comprise one or more anchor oligonucleotides (also referred to herein as oligonucleotides and barcoded oligonucleotides) that are capable of interacting with the reporter oligonucleotide barcode, as described in detail herein.", "Next, in operation 2020, within the partition a nucleic acid molecule comprising at least a portion of the nucleic acid barcode sequence or a complement thereof may be synthesized, as described herein.", "Next, in operation 2030, the nucleic acid molecule may be sequenced to identify the labelling agent or the cell.", "In some cases, the labelling agent and/or the reporter oligonucleotide may be delivered into the cell, e.g., by transfection (e.g., using transfectamine), by lipid (e.g., 1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC)), or by transporter proteins.", "As described herein, a labelling agent may comprise an antibody, an antibody fragment, a cell surface receptor binding molecule, a receptor ligand, a small molecule, a bi-specific antibody, a bi-specific T-cell engager, a T-cell receptor engager, a B-cell receptor engager, a pro-body, an aptamer, a monobody, an affimer, a darpin, a protein scaffold, and the like, and any combination thereof.", "As described herein, a cell surface feature may comprise a receptor, an antigen, a surface protein, a transmembrane protein, a cluster of differentiation protein, a protein channel, a protein pump, a carrier protein, a phospholipid, a glycoprotein, a glycolipid, a cell-cell interaction protein complex, an antigen-presenting complex, a major histocompatibility complex, an engineered T-cell receptor, a T-cell receptor, a B-cell receptor, a chimeric antigen receptor, a gap junction, an adherens junction., and the like, and any combination thereof.", "In some instances, prior to operation 2010, labelling agents may be subjected to conditions suitable for binding the labelling agents to cell surface features.", "In some instances, prior to operation 2010, labelling agents may be subjected to conditions suitable for binding the labelling agents to cell surface features when the cell and the labelling agents are free from the partition (e.g., prior to partitioning).", "In some instances, prior to operation 2010, the reporter oligonucleotide may be coupled to the labelling agent.", "In some instances, in operation 2010, at least one labelling agent is bound to the cell surface feature.", "In some instances, in operation 2020, the reporter oligonucleotide coupled to the labelling agent may be subjected to a primer extension reaction that generates the nucleic acid molecule.", "In some instances, in operation 2020, the anchor oligonucleotide may be coupled to a bead also partitioned with the cell and labelling agent(s), as described herein, and the method further comprises releasing the anchor oligonucleotide from the bead prior to synthesizing.", "As described herein, the bead may comprise a gel bead.", "Further, as described herein, the bead may comprise a diverse library of anchor oligonucleotides.", "In some instances, the bead may comprise at least about 1,000 copies of an anchor oligonucleotide, at least about 10,000 copies of an anchor oligonucleotide, at least about 100,000 copies of an anchor oligonucleotide, at least about 100,000 copies of an anchor oligonucleotide, at least about 1,000,000 copies of an anchor oligonucleotide, at least about 5,000,000 copies of an anchor oligonucleotide, or at least about 10,000,000 copies of an anchor oligonucleotide.", "In some instances, the bead may comprise at least about 1,000 copies of diverse anchor oligonucleotides, at least about 10,000 copies of diverse anchor oligonucleotides, at least about 100,000 copies of diverse anchor oligonucleotides, at least about 100,000 copies of diverse anchor oligonucleotides, at least about 1,00,000 copies of diverse anchor oligonucleotides, at least about 5,000,000 copies of diverse anchor oligonucleotides, or at least about 10,000,000 copies of diverse anchor oligonucleotides.", "In some instances, and as described herein, releasing anchor oligonucleotides from the bead may comprise subjecting the bead to a stimulus that degrades the bead.", "In some instances, as described herein, releasing anchor oligonucleotides from the bead may comprise subjecting the bead to a chemical stimulus that degrades the bead.", "A solid support (e.g., a bead) may comprise different types of anchor oligonucleotides for analyzing both intrinsic and extrinsic information of a cell.", "For example, a solid support may comprise one or more of the following: 1) an anchor oligonucleotide comprising a primer that binds to one or more endogenous nucleic acids in the cell; 2) an anchor oligonucleotide comprising a primer that binds to one or more exogenous nucleic acids in the cell, e.g., nucleic acids from a microorganism (e.g., a virus, a bacterium) that infects the cell, nucleic acids introduced into the cell (e.g., such as plasmids or nucleic acid derived therefrom), nucleic acids for gene editing (e.g., CRISPR-related RNA such as crRNA, guide RNA); 3) an anchor oligonucleotide comprising a primer that binds to a barcode (e.g., a barcode of a nucleic acid, of a protein, or of a cell); and 4) an anchor oligonucleotide comprising a sequence (e.g., a primer) that binds to a protein, e.g., an exogenous protein expressed in the cell, an protein from a microorganism (e.g., a virus, a bacterium) that infects the cell, or an binding partner for a protein of the cell (e.g., an antigen for an immune cell receptor).", "In some cases, the methods may be used to screen cells carrying mutations, e.g., mutations generated by gene editing such as CRISPR technology.", "For example, a bead comprising a first anchor oligonucleotide with a primer for CRISPR RNA (e.g., crRNA or guide RNA) or its complementary DNA and a second anchor oligonucleotide with a primer endogenous nucleic acid in the cell, e.g., total mRNA or a specific mRNA.", "The bead may be made into a partition with a cell transfected with CRISPR RNA or a plasmid expressing CRISPR RNA.", "In some cases, the expressed CRISPR RNA or the plasmid may have a barcode (CRISPR barcode).", "The primers on the bead may be used to amplify and sequence the CRISPR RNA and endogenous mRNA, thus determining the mutations generated by in the cell.", "In some cases, the methods may be used to perform single cell RNA sequencing, e.g., as described in Dixit et al., Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens Cell 167 (7), 1853-1866.e17.2016, which is incorporated herein by reference in its entirety.", "An oligonucleotide of an anchor agent or a labelling agent may comprise a backbone.", "The backbone may comprise one or more of the following elements: a sequencer primer, a barcode, and a UMI.", "In addition to the backbone, the oligonucleotide may also comprise a primer as described herein, e.g., a poly-T primer, a random N-mer primer, and/or a target-specific primer.", "Examples of oligonucleotides comprising various backbones and primer sequences are shown in FIGS.", "27A-27D.", "An example work flow for the methods herein may include inputting fixed reference (e.g., known transcripts from a cell with intrinsic information), reference templates (e.g., design of synthetic barcodes (random or target-specific) with extrinsic information, and sequence reads; and outputting classification of sequence reads as originating from intrinsic or extrinsic sequences, counts of detected copies per transcript/gene per partition, and list and counts of detected barcodes from extrinsic sequences per partition.", "In some cases, the example workflow may be implemented with software.", "In some instances, prior to operation 2030, the method 2000 may comprise releasing the nucleic acid molecule from the partition (e.g., by disruption of the partition).", "In some instances, operation 2030 may comprise identifying the labelling agent (e.g., the labelling agent bound to a cell surface feature).", "In some instances, operation 2030 may comprise identifying the cell surface feature from identifying the labelling agent.", "In some instances, operation 2030 comprises determining an abundance of the given cell surface feature on the cell.", "In some instances, operation 2030 comprises identifying the cell.", "In some instances, operation 2030 comprises identifying the labelling agent and the cell.", "In method 2000, the reporter oligonucleotide that may be coupled to the labelling agent may comprise a unique molecular identification (UMI) sequence, as described herein.", "The UMI sequence may permit identification of the cell, the labelling agent, or both.", "In some instances, operation 2030 of method 2000 may comprise determining a sequence of the UMI sequence and identifying the cell.", "In method 2000, the anchor oligonucleotide may comprise a unique molecular identification (UMI) sequence, as described herein.", "In these instances, the UMI sequence of the anchor oligonucleotide may permit identification of the cell.", "In some instances, operation 2030 of method 2000 may comprise determining a sequence of the UMI sequence from the reporter oligonucleotide bound to the labelling agent, and a sequence of the UMI sequence from the anchor oligonucleotide, to identify the cell and the cell surface feature.", "In method 2000, and as described herein, the partition may comprise a droplet in an emulsion.", "In some instances, the partition comprises only one cell.", "In some instances, the cell is bound to at least one labelling agent.", "In some instances, the labelling agent may comprise at least two of the same labelling agent.", "In some instances, the labelling agent may comprise at least two different labelling agents.", "In some instances, the cell may be bound to at least about 5 different labelling agents, at least about 10 different labelling agents, at least about 50 different labelling agents, at least about 100 different labelling agents, at least about 500 different labelling agents, at least about 1,000 different labelling agents, at least about 5,000 different labelling agents, at least about 10,000 different labelling agents, or at least about 50,000 different labelling agents.", "In some instances, the cell may be bound to between about 2 and 5 different labelling agents, between about 5 and 10 different labelling agents, between about 10 and 100 different labelling agents, between about 100 and 500 different labelling agents, between about 500 and 1,000 different labelling agents, between about 1,000 and 5,000 different labelling agents, between about 5,000 and 10,000 different labelling agents, between about 10,000 and 50,000 different labelling agents, or between about 2 and 50,000 different labelling agents, or any range in-between.", "In some instances, operation 2030 of method 2000 may comprise determining an identity of at least a subset of the different labelling agents.", "In one example process, a sample is provided that contains cells that are to be analyzed and characterized as to their cell surface features.", "A cell surface feature may include, but is not limited to, a receptor, an antigen, a surface protein, a transmembrane protein, a cluster of differentiation protein, a protein channel, a protein pump, a carrier protein, a phospholipid, a glycoprotein, a glycolipid, a cell-cell interaction protein complex, an antigen-presenting complex, a major histocompatibility complex, an engineered T-cell receptor, a T-cell receptor, a B-cell receptor, a chimeric antigen receptor, a gap junction, an adherens junction, or any combination thereof.", "Also provided is at least one labelling agent, such as a library of labelling agents, capable of binding to a cell surface feature of interest.", "A labelling agent may include, but is not limited to, an antibody, an antibody fragment, a cell surface receptor binding molecule, a receptor ligand, a small molecule, a bi-specific antibody, a bi-specific T-cell engager, a T-cell receptor engager, a B-cell receptor engager, a pro-body, an aptamer, a monobody, an affimer, a darpin, and a protein scaffold, or any combination thereof.", "The labelling agents can include a reporter oligonucleotide that is indicative of the cell surface feature to which the binding group binds.", "In particular, a labelling agent that is specific to one type of cell surface feature may have coupled thereto a first reporter oligonucleotide, while a labelling agent that is specific to a different cell surface feature may have a different reporter oligonucleotide coupled thereto.", "In some aspects, these reporter oligonucleotides may comprise nucleic acid barcode sequences that permit identification of the labelling agent which the reporter oligonucleotide is coupled to.", "The selection of oligonucleotides as the reporter may provide advantages of being able to generate significant diversity in terms of sequence, while also being readily attachable to most biomolecules, e.g., antibodies, etc., as well as being readily detected, e.g., using sequencing or array technologies.", "In some embodiments, the labelling agents may include reporter oligonucleotides attached to them.", "Thus, a first labelling agent, e.g., an antibody to a first cell surface feature, may have associated with it a reporter oligonucleotide that has a first nucleic acid sequence.", "Different labelling agents, e.g., antibodies having binding affinity for other, different cell surface features, may have associated therewith reporter oligonucleotides that comprise different nucleic acid sequences, e.g., having a partially or completely different nucleic acid sequence.", "In some cases, for each type of cell surface feature labelling agent, e.g., antibody or antibody fragment, the reporter oligonucleotide sequence may be known and readily identifiable as being associated with the known cell surface feature labelling agent.", "These reporter oligonucleotides may be directly coupled to the labelling agent, or they may be attached to a bead, molecular lattice, e.g., a linear, globular, cross-linked, or other polymer, or other framework that is attached or otherwise associated with the labelling agent, which allows attachment of multiple reporter oligonucleotides to a single labelling agent.", "In the case of multiple reporter oligonucleotides coupled to a single labelling agent, such reporter oligonucleotides can comprise the same sequence, or a particular labelling agent may include a known set of reporter oligonucleotide sequences.", "As between different labelling agents, e.g., specific for different cell surface features, the reporter oligonucleotides may be different and attributable to the particular labelling agent.", "Attachment of the reporter oligonucleotides to the labelling agents may be achieved through any of a variety of direct or indirect, covalent or non-covalent associations or attachments.", "For example, in the case of oligonucleotide reporter oligonucleotides associated with antibody based labelling agents, such oligonucleotides may be covalently attached to a portion of an antibody or antibody fragment using chemical conjugation techniques (e.g., Lightning-Link® antibody labelling kits available from Innova Biosciences), as well as other non-covalent attachment mechanisms, e.g., using biotinylated antibodies and oligonucleotides (or beads that include one or more biotinylated linker, coupled to oligonucleotides) with an avidin or streptavidin linker.", "Antibody and oligonucleotide biotinylation techniques are available.", "See, e.g., Fang, et al., “Fluoride-Cleavable Biotinylation Phosphoramidite for 5′-end-Labelling and Affinity Purification of Synthetic Oligonucleotides,” Nucleic Acids Res.", "Jan. 15, 2003; 31(2):708-715, which is entirely incorporated herein by reference for all purposes.", "Likewise, protein and peptide biotinylation techniques have been developed and are readily available.", "See, e.g., U.S. Pat.", "No.", "6,265,552, which is entirely incorporated herein by reference for all purposes.", "Furthermore, click reaction chemistry such as a Methyltetrazine-PEG5-NHS Ester reaction, a TCO-PEG4-NHS Ester reaction, or the like, may be used to couple reporter oligonucleotides to labelling agents.", "In the case that the labelling agent is a primary antibody, a reporter oligonucleotide may be coupled to the labelling agent through a secondary antibody coupling interaction.", "Commercially available kits, such as those from Thunderlink and Abcam, and techniques common in the art may be used to couple reporter oligonucleotides to labelling agents as appropriate.", "In some cases, a reporter oligonucleotide may be associated (e.g., covalently linked such as conjugated or non-covalently bound through a binding interaction) to an antibody via an antibody-binding protein.", "For example, a reporter oligonucleotide and an antibody-binding protein may form a complex.", "The complex may bind to a respective antibody through the antibody-binding protein.", "FIG.", "28 shows an example workflow for associating a nucleic acid (e.g., DNA) barcode on an antibody using an antibody-binding protein.", "An antibody binding protein 2810, e.g., Protein A or Protein G, and an oligonucleotide comprising a nucleic acid (e.g., DNA) barcode 2820 are conjugated to the Fc region of an antibody, forming a complex 2830 comprising the antibody, the antibody-binding protein 2810, and the DNA barcode 2820.The complex 2830 is incubated with cells and unbound antibody is washed out.", "When the complex 2830 binds to a cell, the complex and the cell are partitioned into a droplet for further analysis.", "An antibody-binding protein may have fast adsorption kinetics, slow desorption kinetics, and/or a low binding equilibrium constant.", "Any methods for adding chemical functionality to peptides or proteins may be used.", "Some methods may include attaching a reporter oligonucleotide to specific amino acids or chemical groups (e.g., chemical groups present in multiple types of proteins) on the antibody-binding protein.", "The conjugation of antibody-binding proteins and oligonucleotides may be performed using methods for forming antibody-nucleic acid conjugation described herein, e.g., using click chemistry.", "Dissociation of the antibody-binding protein/oligonucleotide complexes may be prevented by crosslinking (e.g., using a crosslinker such as formaldehyde), protein engineering, or adding the protein-binding proteins in excess.", "Examples of antibody-binding proteins include proteins that bind to the constant (Fc) region of antibodies, such as Protein A, Protein G, Protein L, or fragments thereof.", "Other binding proteins (e.g., streptavidin) may be expressed as fusion proteins with antibody-binding proteins, and used to associate oligonucleotides (e.g., by binding of biotinylated oligonucleotides to a streptavidin-Protein A fusion protein).", "Other antibody-binding proteins or domains may provide additional binding affinity for various antibody classes.", "In some cases, the antibody-binding protein may be an antibody, e.g., a secondary antibody for the antibody targeting the sample.", "The secondary antibody may comprise an oligonucleotide described here, e.g., an oligonucleotide with a barcode and a poly-A or poly T terminated sequence.", "The antibody-binding proteins may be engineered to introduce additional functionalities.", "Antibody-binding proteins may be engineered to contain amino acids with functional groups amenable to conjugation with oligonucleotide.", "For example, the antibody-binding proteins may naturally have or be engineered to have cysteine residues, e.g., for controlling stoichiometry and/or attachment location of the oligonucleotides.", "The antibody-binding proteins may be engineered to have non-natural amino acid residues, e.g., for targeted crosslinking of binding proteins and antibodies.", "The antibody-binding proteins may be engineered to have tags, e.g., fluorescent tags (e.g., by fusing with a fluorescent protein such as green fluorescence protein (GFP), red fluorescence protein (RFP), yellow fluorescence protein (YFP)) and/or affinity tags for purification and visualization.", "The fluorescent tags and/or the affinity tags may be cleavable.", "In some cases, the antigen-binding protein may be engineered to have one or more (e.g., only one) barcode attachment sites per protein.", "Also provided herein are kits comprising antibody-binding proteins conjugated with reporter oligonucleotides, e.g., in well plates.", "Antibody for an assay may be incubated with the antibody-binding proteins conjugated with reporter oligonucleotides at a specified concentration without interfering with the antibody's binding site and/or without the need for any chemistry to be carried out in the customer's hands to conjugate the reporter oligonucleotide to the antibody.", "The reporter oligonucleotides may be provided having any of a range of different lengths, depending upon the diversity of reporter oligonucleotides suitable for a given analysis, the sequence detection scheme employed, and the like.", "In some cases, these reporter oligonucleotides can be greater than or equal to about 5 nucleotides in length, greater than or equal to about 10 nucleotides in length, greater than or equal to about 5, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 120, 150, 200 or 250 nucleotides in length.", "In some cases, these reporter oligonucleotides may be less than or equal to about 250, 200, 180, 150, 120 100, 90, 80, 70, 60, 50, 40, 30, 20, 10 or 5 nucleotides in length.", "In some cases, the reporter oligonucleotides may be selected to provide barcoded products that are already sized, and otherwise configured to be analyzed on a sequencing system.", "For example, these sequences may be provided at a length that ideally creates sequenceable products of a suitable length for particular sequencing systems.", "Likewise, these reporter oligonucleotides may include additional sequence elements, in addition to the reporter sequence, such as sequencer attachment sequences, sequencing primer sequences, amplification primer sequences, or the complements to any of these.", "In operation, a cell-containing sample may be incubated with the labelling agents and their associated reporter oligonucleotides, for any of the cell surface features to be analyzed.", "Following incubation, the cells may be washed to remove unbound labelling agents.", "Following washing, the cells may be partitioned into separate partitions, e.g., droplets, along with the barcode (also referred to as anchor oligonucleotides) carrying beads described above, where each partition includes a limited number of cells, e.g., a single cell.", "Upon releasing of the barcodes (or anchor oligonucleotides) from the beads, they may prime the amplification and barcoding of the reporter oligonucleotides coupled to the labelling agents.", "The barcoded replicates of the reporter oligonucleotides may additionally include functional sequences, such as primer sequences, attachment sequences or the like.", "The barcoded reporter oligonucleotides may then subjected to sequence analysis to identify which reporter oligonucleotides were bound to the cells (i.e., cell surface features) within the partitions.", "Further, by also sequencing the associated barcode sequence, one can identify that a given cell surface feature likely came from the same cell as other, different cell surface features, whose reporter sequences include the same barcode sequence, i.e., they were derived from the same partition.", "In some embodiments, anchor oligonucleotides within the partition may interact with the reporter oligonucleotides coupled to labelling agents bound to cell surface features and lead to the synthesizing of a nucleic acid molecule as described herein, where the synthesized nucleic acid molecule may comprise at least a portion of the nucleic acid barcode sequence(s), or complement(s) thereof, that comprise the reporter oligonucleotide, or the anchor oligonucleotide, or both.", "These synthesized nucleic acid molecules may then be subjected to amplification and sequencing, as described herein.", "In some embodiments, more than one labelling agent may be bound to a single cell surface feature, and proximity between the labelling agents may allow the 3′ ends of the reporter oligonucleotides coupled thereto to hybridize (wherein this hybridization is discouraged by the melting temperature when unbound in solution).", "By an extension reaction as described herein, a nucleic acid molecule may be synthesized, amplified, and subjected to sequencing, as described herein.", "Based upon the reporter oligonucleotides that emanate from an individual partition based upon the presence of the barcode sequence, one may then create a cell surface feature profile of individual cells from a population of cells.", "Profiles of individual cells or populations of cells may be compared to profiles from other cells, e.g., ‘normal’ cells, to identify variations in cell surface features, which may provide diagnostically relevant information.", "In particular, these profiles may be particularly useful in the diagnosis of a variety of disorders that are characterized by variations in cell surface receptors, such as cancer and other disorders.", "In some embodiments, the genomic, proteomic, and cell surface information of cells characterized by the methods and systems described herein may be sequenced individually.", "In some embodiments, the genomic, proteomic, and cell surface information of cells characterized by the methods and systems described herein may be pooled and sequenced together.", "In some embodiments, the genomic, proteomic, and cell surface information of cells characterized by the methods and systems described herein may be sequenced sequentially (i.e., cell surface information characterized first, then proteomic and genomic information).", "Also provided herein are compositions and methods for screening a chemical compound library.", "The methods may comprise providing a partition comprising at least one chemical compound and an identifier of the partition.", "The identifier may be an oligonucleotide comprising a nucleic acid barcode sequence as described in the application.", "The identifier oligonucleotide may be amplified and subject to sequence.", "The sequence read of the identifier oligonucleotide or a fragment thereof may be used to identify the partition and the at least one chemical compound in the partition.", "The methods may be used for screening a chemical compound library in a reaction of small volumes, e.g., on the scale of nanoliters.", "Multiple reactions may be performed in different partitions with the same substrate and/or reagent.", "The reaction may be multiplexed to decrease the effort and time needed to process the same number of compounds in reactions of larger scale, e.g., on the scale of microliters.", "The methods and compositions may allow high throughput screening of a chemical compound library with low noise and/or false-positive results.", "In some cases, a method for screening a chemical compound library may comprise one or more of the following operations: (1) providing a plurality of partitions, wherein a given partition of the plurality of partitions (i) has or is suspected of having at least one chemical compound and (ii) comprises an identifier oligonucleotide comprising a nucleic acid barcode sequence that permits identification of the given partition; (2) subjecting the plurality of partitions to screening under conditions sufficient to select a subset of the plurality of partitions from a remainder of the plurality of partitions, which subset comprises the given partition having or suspected of having the at least one chemical compound; (3) subjecting the subset of the plurality of partitions, including the given partition, to conditions sufficient to generate a nucleic acid molecule comprising at least a portion of the nucleic acid barcode sequence or a complement thereof; and (4) sequencing the nucleic acid molecule to generate sequence reads, which sequence reads permit identification of the at least one chemical compound.", "The methods may comprise building combinatorial chemical and identifier oligonucleotide libraries on a solid support, e.g., a monodispersed polymeric bead.", "The oligonucleotide barcoding may be intrinsically linked to a chemical synthesis path unique for that monodispersed polymer bead.", "Upon partitioning this polymeric bead, the population of compounds may be released from the substrate to interact with the target molecule unencumbered by the identifier oligonucleotides.", "Partitions may then be sorted based on positive/negative interactions as indicated by a traditional reporter assay.", "Positives partitions may then be homogenized and pooled.", "The identifier oligonucleotides in the positive partitions may be amplified for sequencing.", "The methods may allow for large quantities of single compounds to be packaged into nanoliter partitions individually and for the subsequent deconvolution of partitions with positive interactions that may be pooled and processed in a multiplexed format.", "In some cases, the methods comprise synthesizing a controlled number of chemical compounds on a solid support (e.g., a bead) while simultaneously synthesizing a controlled number of identifier oligonucleotides unique to the compounds on the solid support.", "The combinatorial libraries of the chemical compounds and identifier oligonucleotides may be made through sequential additions of chemical compound subunits that concord with simultaneous or subsequent sequential additions of identifier oligonucleotides on the solid matrix.", "The methods may be multiplexed in a single vessel for additions of chemical compounds and identifier oligonucleotides in a massively parallel way.", "The quantity of the chemical compounds to be screened may be normalized.", "The number of chemical compounds and/or identifier oligonucleotides synthesized on a solid support may be controlled by adjusting the number of attachment points.", "An attachment point may be a location on a solid support where a chemical compound or identifier oligonucleotide may be attached to.", "Attachment points may include multiple types of chemistries for the cleavage of chemical compounds and/or identifier oligonucleotides.", "This allows for selective release of chemical compounds and/or identifier oligonucleotides in a controlled fashion.", "The solid may have a single or multiple attachment points.", "The solid support may act as a covalent linker between chemical compounds and identifier oligonucleotides.", "A single type of solid support or multiple types of solid support may be used in the screening.", "If multiple types of solid support are used, they may be covalently linked to form a single solid support.", "In certain cases, if multiple types of solid support are used, they may be comingled (but not covalently linked) and occupy the same physical space.", "A solid support may have two or more matrices intermingled.", "In these cases, chemical compounds and the identifier oligonucleotides may be on the same matrix or on separate matrices of the solid support.", "In the latter case, the chemical compounds and the identifier oligonucleotides are comingled (and not covalently linked) and occupy the same physical space.", "In some cases, the solid support may be permeable or non-permeable.", "In certain cases, the solid support may be dissolvable or non-dissolvable.", "A chemical compound may be a protein (e.g., an antibody or a fragment thereof, or an antigen or a fragment thereof), a nucleic acid molecule.", "In some cases, a chemical compound may be a small molecule compound.", "A small molecule compound may be a low molecular weight (e.g., no greater than 1000 daltons) organic compound that may help regulate a biological process.", "A small compound may have a size on the order of 1 nm.", "For example, a small molecule compound may be a small molecule drug.", "Screening of a chemical compound library may be performed using methods for screening small molecules for drug discovery.", "For example, the screening may be performed using high-throughput screening or high-content analysis in drug discovery.", "A high-through screening may be a screening that identifies active compounds, antibodies, or genes that modulate a particular biomolecular pathway.", "A high-content may be a screening that identifies substances such as small molecules, peptides, or RNAi that alter the phenotype of a cell in certain manner.", "In some cases, a screening may be an immunoassay, e.g., enzyme-linked immunosorbent assay (ELISA).", "Also provided herein are scaffolds for delivery of one or more reagents.", "In some cases, a reagent is not covalently bound to the solid scaffold.", "For example, the reagent may be inside the scaffold and hindered (e.g., through steric interaction with the scaffold) from diffusing out of the scaffold.", "The reagent may be released from the scaffold when the scaffold is dissolved.", "In some cases, the scaffold may be a microcapsule described herein, such as a gel bead.", "The scaffold may be used in a method for characterizing a cell.", "The method may comprise providing a partition comprising a cell, a scaffold, and an reagent in the scaffold.", "To characterize the cell in the partition, the scaffold may be dissolved to release the reagent.", "The reagent then contacts with the cell for determining one or more characteristics of the cell.", "In some cases, the partition may comprise a plurality of reagents.", "Any reagent described in the disclosure may be used in this method.", "The scaffold may be used to deliver two or more reagents.", "In some cases, a first reagent be non-covalently bound to the scaffold, and the second reagent may be covalently bound to the scaffold.", "In other cases, multiple scaffolds may be used to deliver multiple reagents.", "In these cases, a first reagent may be covalently bound to a first scaffold, and a second reagent may be non-covalently bound to a second scaffold.", "The first scaffold and the second scaffold may be encapsulated in the same partition with a cell.", "The reagent that is non-covalently bound to the scaffold may be released when the scaffold is dissolved.", "A scaffold is dissolved when at least 0.01%, 0.1, 1%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 99%, or 100% of the volume of the scaffold is dissolved in the solution around it.", "The scaffold may comprise one or more pores and the reagent non-covalently bound to the scaffold may be in the one or more pores.", "The diameter of the one or more pores may be up to 0.01 nm, 0.1 nm, 1 nm, 5 nm, 10 nm, 50 nm, 100 nm, 200 nm, 400 nm, 600 nm, 800 nm, or 10 μm.", "A scaffold loaded with a non-covalently bound reagent may be made using any method of incorporating an agent in a solid substance.", "In some cases, the scaffold loaded with a non-covalently bound reagent may be made using the one or more of following operations: 1) Placing the scaffold (e.g., gel bead) and the reagent under a condition that causes the scaffold to swell and the pores defined by the polymer scaffold to enlarge.", "Such condition may include: in a thermodynamically-favorable solvent, at higher or lower temperatures (e.g., for temperature-responsive hydrogel materials), in a solvent with higher or lower ion concentration and/or in the presence or absence of an electric field for electric charge-/field-responsive hydrogel materials; 2) Allowing sufficient time for the reagent to diffuse into the interior of the scaffold; 3) Transferring the scaffold into a condition that causes the pores to shrink.", "The reagent molecules within the scaffold are then hindered from diffusing out of the scaffold by steric interactions with the polymer scaffold.", "The transfer in operation 3) may be achieved microfluidically, e.g., by moving the scaffold from one co-flowing solvent stream to another.", "FIG.", "29 demonstrates examples of swelling conditions and de-swelling conditions in the process.", "The swellability and pore sizes of the scaffold may be adjusted by changing the polymer composition.", "In a partition comprising a scaffold loaded with non-covalently bound reagent, the composition of the partition may be adjusted by including a scaffold of a certain volume.", "For example, when a partition has a fixed volume, the concentration of the reagent in the partition may be upregulated by including a reagent-loaded scaffold of a larger volume.", "In some cases, the adjustment may be performed without changing the initial concentration of the components in the partition.", "In certain cases, the adjustment may be performed without changing the total volume of the partition.", "Such methods are useful for delivering a reagent that interferes with the partition generation, e.g., a cell lysis agent.", "A partition with the scaffold may be generated using methods described in the disclosure.", "In certain cases, during the partition generation, both the scaffold and the liquid immediately surrounding the scaffold are encapsulated in a single partition as shown in FIG.", "30.The volume of the scaffold and the surrounding liquid comprise a “unit cell”.", "Unit cells may be defined by the geometry of the microchannel in which scaffolds flow and by the pressure applied.", "For example, higher pressures may compress the scaffold, which are deformable, thereby reducing the volume of the unit cell.", "The composition of a partition may be determined by the volume of scaffold suspension (Z1) and the volume of the sample (Z2) encapsulated in that partition.", "The characteristic of the composition may be described by the ratio of these two volumes (Z1/Z2).", "The maximum Z1 possible for single-scaffold encapsulations is equal to the volume of the unit cell.", "Thus, to increase the concentration of a reagent delivered by the scaffold in a partition of a fixed volume without increasing the concentration of the reagent in the scaffold suspension, the dimensions of the scaffold may be increased.", "Thus, the encapsulated unit cell may occupy a greater volume of the partition (at higher Z1/Z2 ratio).", "In a microchannel for making the partitions, the dimension of the microchannel may or may not have to be increased to accommodate the larger partitions, depending on the mechanical properties of the scaffolds.", "When higher pressures are applied, the scaffold may compress, the volume of the unit cell may decrease, and a lower Z1/Z2 ratio may be achieved.", "Also provided herein are methods and compositions for sequencing DNA (e.g., genomic DNA) molecules and RNA (e.g., mRNA) molecules from a cell in parallel and/or simultaneously.", "In some cases, the methods and compositions may be used for sequencing the genome and transcriptome from a single cell in parallel.", "The methods may be useful to dissect the functional consequences of genetic variations.", "A microcapsule (e.g., a bead) entrapping one or more magnetic particles may be used in the methods.", "The magnetic particles may not diffuse out of the microcapsule until the microcapsule is dissolved.", "The microcapsule may comprise an oligonucleotide comprising a DNA primer.", "For example, the DNA primer may be a genomic DNA primer.", "The DNA primer may bind to DNA molecules from a cell.", "The DNA primer may be used to amplify and/or sequence DNA molecules from a cell.", "DNA primers may be entrapped and/or bound to the microcapsule and released when the microcapsule is dissolved.", "The magnetic particles entrapped within the microcapsule may comprise an oligonucleotide comprising an RNA primer.", "The RNA primer may bind to RNA molecules from a cell.", "In some cases, the RNA primer is an mRNA primer that binds to the mRNA molecules from the cell.", "For example, the mRNA primer may comprise a poly-T sequence that binds to the poly-A sequence of the mRNA molecules from the cell.", "FIG.", "31 shows a microcapsule with a barcoded magnetic particle entrapped.", "The magnetic particles may be made from materials such as iron oxide (e.g., superparamagnetic iron oxide), ferromagnetic, ferrimagnetic, or paramagnetic materials.", "Ferromagnetic materials may be strongly susceptible to magnetic fields and capable of retaining magnetic properties when the field can be removed.", "Ferromagnetic materials include, but are not limited to, iron, cobalt, nickel, alloys thereof, and combinations thereof.", "Other ferromagnetic rare earth metals or alloys thereof can also be used to make the magnetic particles.", "The oligonucleotides on both the microcapsule and the magnetic particle may comprise the same barcode sequence.", "The barcode sequence may allow matching the information (e.g., sequence reads) of DNA and RNA from the same cell.", "In some cases, the barcode sequence may comprise a unique identifier of the cell.", "For example, the unique identifier may distinguish a cell from other cells in a sample.", "Thus, the unique identifier may allow parallel analysis of DNA molecules and RNA molecules in a plurality of cells, e.g., at least 10, 50, 100, 200, 300, 400, 500, 600, 800, or 1000 cells.", "For example, the unique identifier may allow parallel analysis of DNA molecules and RNA molecules in a plurality of cells, e.g., at least 200, or 500 cells.", "In some cases, the microcapsule may also contain one or more reagents for analyzing cells.", "For example, the microcapsule may contain a lysis agent.", "When the microcapsule is dissolved, the lysis agent may be released and lyse the cell in the same partition with the microcapsule.", "In some cases, the microcapsule may be a gel bead.", "An example method for making a gel bead with one or more magnetic particles may comprise one or more of the following operations: 1) Magnetic particles are added to the aqueous phase of the material for making the gel beads, e.g., the gel beads monomer mixture; 2) The gel beads are made using a microfluidic approach, e.g., by forming droplets that polymerize to form the gel beads.", "When the droplets polymerize, the magnetic particles are entrapped within; 3) The same barcode sequence is added to the gel bead and the magnetic particles entrapped within, e.g., using dual ligation strategy.", "Once a partition is generated to include a cell, a microcapsule, and a magnetic particle entrapped in the microcapsule, the partition may be incubated with one or more reagents (e.g., a lysis agent) to lyse the cell and dissolve the microcapsule.", "The incubation may be performed on a microfluidic chip device, e.g., with a delay line device as described in Frenz et al., Reliable microfluidic on-chip incubation of droplets in delay-lines.", "Lab Chip.", "2009 May 21; 9(10):1344-8, which is incorporated herein by reference in its entirety.", "After the incubation, the partition may be collected and placed in a container e.g., a strip tube or plate.", "The incubation may be performed for a period that allows sufficient time for the cell to lyse and the magnetic particles to be released from the microcapsule.", "The incubation time may also allow sufficient binding of the RNA primers on the magnetic particles with the RNA molecules from the cell.", "In some cases, the incubation time may be from 1 minute to 100 minutes, from 5 minutes to 50 minutes, from 10 minutes to 30 minutes, or from 10 minutes to 20 minutes.", "One or more RNA molecules bound to the RNA primers on the magnetic particles may be separated from other components in the partition.", "The separation may be performed by concentrating the magnetic particles.", "The magnetic particles may be concentrated by a magnetic field.", "The separation may be performed on a microfluidic device, e.g., a device as described in Gao et al., Wash-free magnetic immunoassay of the PSA cancer marker using SERS and droplet microfluidics, Lab Chip, 2016, 16, 1022-1029; Brouzes et al., Rapid and continuous magnetic separation in droplet microfluidic devices.", "Lab Chip.", "2015 Feb. 7; 15(3):908-19; or Lombardi et al., Droplet microfluidics with magnetic beads: a new tool to investigate drug-protein interactions.", "Anal Bioanal Chem.", "2011 January; 399(1):347-52, which are incorporated herein by reference in their entireties.", "In some cases, the one or more RNA molecules may be separated from DNA molecules.", "The separated RNA molecules and DNA molecules from a single cell may be analyzed using approaches described herein, e.g., sequencing, to determine a characteristic of the cell.", "FIG.", "32 shows a method for parallel sequencing DNA (e.g., genomic DNA) and RNA (e.g., mRNA) in a cell.", "In operation 3210, single cell partitions are prepared by mixing gel beads with magnetic particles, cells and reaction reagents, e.g., a lysis agent.", "Droplets are generated from the mixture.", "A single droplet 3220 contains one cell, a gel bead with magnetic particles, and reaction reagents.", "The gel bead has genomic DNA primers and the magnetic particles have mRNA primers.", "The gel bead and the magnetic particles in the partition have the same barcode sequence.", "In 3230, the gel bead is dissolved to release the magnetic particles and genomic DNA primers.", "The cell is also lysed to release the genomic DNA molecules and mRNA molecules.", "The mRNA molecules are captured on the magnetic particles by binding with the mRNA primers.", "In operation 3240, on a microfluidic device, the partition split into two daughter droplets.", "The magnetic particles with the captured mRNA molecules are collected in only one of the daughter droplets, thus being separated from other components, e.g., genomic DNA in the other daughter droplet.", "Thus, the genomic DNA molecules and mRNA molecules from a single cell are separated and may be used for further analysis.", "Also provided herein are methods and compositions for analyzing one or more proteins and one or more nucleic acids from a sample (e.g., a single cell).", "For example, the methods and compositions may be used for analyzing the proteome, and the genome or transcriptome in a single cell.", "The methods may comprise generating a partition that contains the sample, a labelling agent for proteins and a labelling agent for nucleic acids.", "In some cases, the labelling agent for proteins may interact with one or more proteins in the sample.", "For example, the labelling agent for proteins may comprise an antibody.", "In other cases, the labelling agent for proteins may be coupled with a protein probe that interacts with one or more proteins in the sample.", "For example, the labelling agent for proteins may be coupled with an antibody.", "The labelling agent for nucleic acids may interact with one or more nucleic acids in the sample.", "The labelling agent for nucleic acids may comprise a primer, e.g., a primer that bind to a DNA molecule and/or RNA molecule.", "The labelling agent for proteins and the labelling agent for nucleic acids may comprise the same reporter oligonucleotide.", "The reporter oligonucleotide may comprise a barcode and/or a UMI.", "The barcode and/or the UMI may allow for matching proteins with nucleic acids from the same sample.", "When bound to the labelling agent for nucleic acids, the nucleic acids from a sample may be sequenced.", "The reporter oligonucleotide or a portion thereof may also be sequenced.", "In some cases, the methods may comprise one or more of the following operations: a) providing a partition comprising a biological sample comprising a protein and a first nucleic acid molecule, a labelling agent that is (i) capable of binding to the protein and (ii) is coupled to a reporter oligonucleotide comprising a nucleic acid barcode sequence that permits identification of the labelling agent, a first anchor oligonucleotide coupled to a support, which first anchor oligonucleotide is capable of interacting with the reporter oligonucleotide; and a second anchor oligonucleotide coupled to the support, which second anchor oligonucleotide is capable of interacting with the first nucleic acid molecule; (b) in the partition, synthesizing a second nucleic acid molecule comprising at least a portion of the nucleic acid barcode sequence or a complement thereof; and (c) subjecting the first nucleic acid molecule and the second nucleic acid molecule to sequencing.", "When the labelling agent for proteins and a protein probe is separate molecules, the protein probe may be incubated with the sample before making the partition in operation (a).", "Two anchor agents may be used in the methods.", "The first anchor agent may interact with one or more nucleic acids from a sample.", "Additionally or alternatively, the first anchor agent may be coupled with a labelling agent for nucleic acids.", "For example, the first anchor agent may comprise an oligonucleotide that bind to a labelling agent for nuclei acid.", "The second anchor agent may interact with one or more proteins from a sample.", "Additionally or alternatively, the second anchor agent may interact be coupled with a labelling agent for proteins.", "For example, the second anchor agent may comprise an element that interacts with the labelling agent for proteins.", "In some cases, the second anchor agent may comprise a nucleic acid sequence that interacts with an oligonucleotide sequence coupled to a labelling agent for proteins.", "The labelling agent for proteins may comprise one or more elements.", "The labelling agent may comprise an element (e.g., an oligonucleotide sequence) that interacts with an anchor agent.", "The labelling agent may comprise a reporter oligonucleotide, e.g., an oligonucleotide comprising a barcode that allows for identifying the protein targeted by the labelling agent.", "For example, in the cases where the labelling agent for proteins comprises an antibody, the reporter oligonucleotide may allow for identifying the antibody, thereby identifying the protein bound by the antibody.", "The labelling agent for proteins may comprise a reactive moiety that allows the labelling agent to be coupled with a protein probe, e.g., antibody.", "The labelling agent may be coupled with a protein probe by any chemistry descried herein for attaching a reporter oligonucleotide to a labelling agent.", "In some cases, the reactive moiety may include a click chemistry linker, such as Methyltetrazine-PEG5-NHS Ester or TCO-PEG4-NHS Ester.", "The reactive moiety on the labelling agent may also include amine for targeting aldehydes, amine for targeting maleimide (e.g., free thiols), azide for targeting click chemistry compounds (e.g., alkynes), biotin for targeting streptavidin, phosphates for targeting EDC, which in turn targets active ester (e.g., NH2).", "The reactive moiety on the protein probe may be a chemical compound or group that binds to the reactive moiety on the labelling agent.", "Example strategies to conjugate the protein probe to the labelling agent include using of commercial kits (e.g., Solulink, Thunder link), conjugation of mild reduction of hinge region and maleimide labelling, stain-promoted click chemistry reaction to labeled amides (e.g., copper-free), and conjugation of periodate oxidation of sugar chain and amine conjugation.", "In the cases where the protein probe is an antibody, the antibody may be modified for conjugating the reporter oligonucleotide.", "For example, the antibody may be glycosylated with a substrate-permissive mutant of β-1,4-galactosyltransferase, GalT (Y289L) and azide-bearing uridine diphosphate-N-acetylgalactosamine analog uridine diphosphate-GalNAz.", "The modified antibody may be conjugated with a reporter oligonucleotide with a dibenzocyclooctyne-PEG4-NHS group.", "FIG.", "33 shows example strategies for antibody-reporter oligonucleotide conjugation.", "In some cases, some strategy (e.g., COOH activation (e.g., EDC) and homobifunctional cross linkers) may be avoided to prevent the protein probes from conjugating to themselves.", "The two anchor agents may be coupled to a solid support, e.g., a microcapsule.", "For example, the microcapsule may be a bead, e.g., a gel bead.", "In some cases, the two anchor agents are coupled to the same solid support.", "In other cases, the two anchor agents are coupled to different solid supports.", "The two anchor agent may comprise the same reporter oligonucleotide.", "FIG.", "34 shows example reagents used in the methods.", "An anchor agent 3420 is coupled to a bead 3410.The anchor agent comprises a barcode sequence 3422 and a UMI 3423.The anchor agent also comprises an oligonucleotide sequence 3424 that allows binding to the labelling agent 3430.The labelling agent 3430 comprises an oligonucleotide 3431 for binding to the anchor agent.", "The labelling agent 3430 also comprises a barcode 3432 that allows identifying the antibody it is coupled to.", "The labelling agent 3430 further comprises a reactive moiety 3434 that allows the labelling agent to couple with an antibody 3440.An additional example of reagents and schemes suitable for analysis of barcoded labelling agents is shown in panels I and II of FIG.", "52B.", "As shown in FIG.", "52B (panel I), a labelling agent (e.g., antibody, an MHC moiety) 5201 is directly (e.g., covalently bound, bound via a protein-protein interaction, such as with Protein G) coupled to an oligonucleotide 5202 comprising a barcode sequence 5203 that identifies the label agent 5201.Oligonucleotide 5202 also includes additional sequences (sequence 5204 comprising a reverse complement of a template switch oligo and sequence 5205 comprising a PCR handle) suitable for downstream reactions.", "FIG.", "52B (panel I) also shows an additional oligonucleotide 5206 (e.g., which may have been released from a bead as described elsewhere herein) comprising a barcode sequence 5208, a UMI sequence 5209 and additional sequences (sequence 5207 comprising a sequencing read primer binding site ‘pR1’ and sequence 5210 comprising a template switch oligo) suitable for downstream reactions.", "During analysis, the labelling agent is bound to its target cell surface feature and the rGrGrG sequence of sequence 5210 hybridizes with sequence 5204 and both oligonucleotides 5202 and 5206 are extended via the action of a polymerizing enzyme (e.g., a reverse transcriptase, a polymerase), where oligonucleotide 5206 then comprises complement sequences to oligonucleotide 5202 at its 3′ end.", "These constructs can then be optionally processed as described elsewhere herein and subject to sequencing to, for example, identify the target cell surface feature (via the complementary barcode sequence generated from oligonucleotide 5202) and associate it with the cell, identified by the barcode sequence of oligonucleotide 5206.In another example, shown in FIG.", "52B (panel II), a labelling agent (e.g., antibody) 5221 is indirectly (e.g., via hybridization) coupled to an oligonucleotide 5222 comprising a barcode sequence 5223 that identifies the label agent 5221.Labelling agent 5221 is directly (e.g., covalently bound, bound via a protein-protein interaction, such as with Protein G) coupled to a hybridization oligonucleotide 5232 that hybridizes with sequence 5231 of oligonucleotide 5222.Hybridization of oligonucleotide 5232 to oligonucleotide 5231 couples label agent 5221 to oligonucleotide 5222.Oligonucleotide 5222 also includes additional sequences (sequence 5224 comprising a reverse complement of a template switch oligo and sequence 5225 comprising a PCR handle) suitable for downstream reactions.", "FIG.", "52B (panel II) also shows an additional oligonucleotide 5226 (e.g., which may have been released from a bead as described elsewhere herein) comprising a barcode sequence 5228, a UMI sequence 5229 and additional sequences (sequence 5227 comprising a sequencing read primer binding site ‘pR1’ and sequence 5220 comprising a template switch oligo) suitable for downstream reactions.", "During analysis, the labelling agent is bound to its target cell surface feature and the rGrGrG sequence of sequence 5220 hybridizes with sequence 5224 and both oligonucleotides 5222 and 5226 are extended via the action of a polymerizing enzyme (e.g., a reverse transcriptase, a polymerase), where oligonucleotide 5226 then comprises complement sequences to oligonucleotide 5222 at its 3′ end.", "These constructs can then be optionally processed as described elsewhere herein and subject to sequencing to, for example, identify the target cell surface feature (via the complementary barcode sequence generated from oligonucleotide 5222) and associate it with the cell, identified by the barcode sequence of oligonucleotide 5226.An example of the methods for analyzing mRNA molecules and proteins from a single cell is shown in FIGS.", "35A and 35B.", "The method uses a barcoded antibody 3510 containing an antibody 3511 conjugated with an oligonucleotide 3512.The oligonucleotide 3512 can bind to a first anchor oligonucleotide 3520 coupled to a bead.", "The barcoded antibody 3510 is incubated with cells such that the antibody binds to an antigen on the cell, and form antibody-cell complexes (FIG.", "35A).", "Unbound antibodies are washed out.", "The antibody-cell complexes are made into emulsion partitions.", "Each partition contains an antibody-cell complex, the first anchor oligonucleotide 3520, and a second anchor oligonucleotide 3530 that binds to mRNA molecules from the cell.", "The cell is lysed and the mRNA molecules are released from the cell.", "As shown in FIG.", "35B, the mRNA molecules are reverse transcribed to cDNA and amplified with the help of the second anchor oligonucleotide.", "The amplified cDNA molecules have the barcode and UMI that are the same as the barcode and UMI on the first anchor oligonucleotide 3520.Primer extension is performed on the complex of the first anchor oligonucleotide 3520 and the oligonucleotide 3512, thus generating a reporter oligonucleotide 3550 comprising the barcode and UMI the same as those on the second anchor oligonucleotide.", "The reporter oligonucleotide 3550 also comprises an antibody identifier (antibody barcode (AbBC)) that identifies the antibody and the antigen bound by the antibody.", "When the cDNA molecules are sequenced, the sequence reads are correlated to the antigen in the same cell using the barcode and UMI.", "FIG.", "35C shows the primer extension of the first anchor oligonucleotide and oligonucleotide 3512 conjugated with the antibody.", "The resulting oligonucleotides may be separated from cDNA synthesized from mRNA from the cell (e.g., by size-based selection).", "The first anchor oligonucleotide and the complex of the second anchor oligonucleotide with oligonucleotide 3512 may be processed and/or sequenced separately or jointly.", "In some cases, the anchor agents 3520 and 3530 may be coupled to the same bead.", "Also provided herein are the microfluidic devices used for partitioning the cells as described above.", "Such microfluidic devices can comprise channel networks for carrying out the partitioning process like those set forth in FIGS.", "1 and 2.Briefly, these microfluidic devices can comprise channel networks, such as those described herein, for partitioning cells into separate partitions, and co-partitioning such cells with oligonucleotide barcode library members, e.g., disposed on beads.", "These channel networks can be disposed within a solid body, e.g., a glass, semiconductor or polymer body structure in which the channels are defined, where those channels communicate at their termini with reservoirs for receiving the various input fluids, and for the ultimate deposition of the partitioned cells, etc., from the output of the channel networks.", "By way of example, and with reference to FIG.", "2, a reservoir fluidly coupled to channel 202 may be provided with an aqueous suspension of cells 214, while a reservoir coupled to channel 204 may be provided with an aqueous suspension of beads 216 carrying the oligonucleotides.", "Channel segments 206 and 208 may be provided with a non-aqueous solution, e.g., oil, into which the aqueous fluids are partitioned as droplets at the channel junction 212.An outlet reservoir may be fluidly coupled to channel 210 into which the partitioned cells and beads can be delivered and from which they may be harvested.", "As will be appreciated, while described as reservoirs, it will be appreciated that the channel segments may be coupled to any of a variety of different fluid sources or receiving components, including tubing, manifolds, or fluidic components of other systems.", "Also provided are systems that control flow of these fluids through the channel networks e.g., through applied pressure differentials, centrifugal force, electrokinetic pumping, capillary or gravity flow, or the like.", "Also provided herein are kits for analyzing individual cells or small populations of cells.", "The kits may include one, two, three, four, five or more, up to all of partitioning fluids, including both aqueous buffers and non-aqueous partitioning fluids or oils, nucleic acid barcode libraries that are releasably associated with beads, as described herein, labelling agents, as described herein, anchor oligonucleotides, as described herein, microfluidic devices, reagents for disrupting cells amplifying nucleic acids, and providing additional functional sequences on fragments of cellular nucleic acids or replicates thereof, as well as instructions for using any of the foregoing in the methods described herein.", "Another aspect of the disclosure provides a composition for characterizing a plurality of analytes, comprising a partition comprising a plurality of barcode molecules and the plurality of analytes.", "The plurality of barcode molecules can also include at least 1,000 barcode molecules.", "Moreover, (i) a first individual barcode molecule of the plurality of barcode molecules can comprise a first nucleic acid barcode sequence that is capable of coupling to a first analyte of the plurality of analytes; and (ii) a second individual barcode molecule of the plurality of barcoded molecules can comprise a second nucleic acid barcode sequence that is capable of coupling to a second analyte of the plurality of analytes, where the first analyte and the second analyte are different types of analytes (e.g., DNA and RNA, DNA and protein, RNA and protein, or DNA, RNA and protein).", "In some cases, the composition comprises a plurality of partitions comprising the partition.", "An additional aspect of the disclosure provides a method for analyte characterization.", "The method comprises: (a) providing a plurality of partitions, where a given partition of the plurality of partitions comprises a plurality of barcode molecules and a plurality of analytes.", "The plurality of barcode molecules can comprise at least 1,000 barcode molecules.", "Moreover, (i) a first individual barcode molecule of the plurality of barcode molecules can comprise a first nucleic acid barcode sequence that is capable of coupling to a first analyte of the plurality of analytes; and (ii) a second individual barcode molecule of the plurality of barcoded molecules can comprise a second nucleic acid barcode sequence that is capable of coupling to a second analyte of the plurality of analytes; where the first analyte and the second analyte are different types of analytes.", "The method also includes (b) in said given partition (i) synthesizing a first nucleic acid molecule comprising at least a portion of the first nucleic acid barcode sequence or complement thereof; and (ii) synthesizing a second nucleic acid molecule comprising at least a portion of the second nucleic acid barcode sequence or complement thereof; and (c) removing said first nucleic acid molecule and said second molecule from said given partition.", "In some cases, the method further comprises subjecting the first nucleic acid molecule and the second nucleic acid molecule, or a derivative of the first nucleic acid molecule and/or second nucleic acid molecule, to sequencing to characterize the first and/or the second analyte.", "Characterizing the first analyte and/or the second analyte generally provides information regarding the first analyte and/or second analyte.", "This information can be used to select first and/or second analytes for one or more additional cycles of (a)-(c).", "Accordingly, the method may further comprise repeating (a)-(c) based on a characterization of the first analyte or the second analyte from sequencing.", "In some cases, the method further comprises selecting the first analyte and/or the second analyte based on a characterization of the first analyte or the second analyte obtained from the sequencing a subsequent sequencing upon repeating (a)-(c).", "Moreover, in some cases, (b) further comprises: (1) synthesizing the first nucleic acid molecule comprising at least a portion of the first nucleic acid barcode sequence or complement thereof, and (2) synthesizing the second nucleic acid molecule comprising at least a portion of the second nucleic acid barcode sequence or complement thereof.", "For example, the first nucleic acid molecule and/or the second nucleic acid molecules may be synthesized with the aid of one or more primer extension reactions that make use of a primer that hybridizes with a first or second analyte.", "Such a primer may comprise a barcode sequence and/or a UMI sequence as described elsewhere herein.", "In some cases, the first nucleic acid molecule and/or the second nucleic acid molecule may be synthesized with the aid of ligation between two nucleic acid molecules.", "In some cases, the method further comprises performing one or more reactions subsequent to removing the first nucleic acid molecule and the second nucleic acid molecule from the given partition.", "Such reactions can include the addition of additional nucleic acid sequences (e.g., sample index sequences, a sequence for function in a particular sequencing platform) via additional primer extension reactions, nucleic acid amplification schemes (e.g., PCR) or ligation.", "In some cases, portions of the first and/or second nucleic acid molecules may be removed (e.g., via restriction enzymes, via shearing) prior to or after the addition of additional nucleic acid sequences.", "Moreover, these reactions can be performed in bulk, such that processing of the first and second nucleic acid molecules and first and second nucleic acid molecules from other partitions are processed simultaneously in bulk.", "Such processing can be completed in a single pot reaction.", "Examples of such one or more other reactions are provided in U.S. Patent Publication No.", "2015/0376609, which is entirely incorporated herein by reference.", "An additional aspect of the disclosure provides a system for characterizing a plurality of analytes.", "The system comprises a partitioning unit for providing a partition comprising a plurality of barcode molecules and the plurality of analytes, where: (i) a first individual barcode molecule of the plurality of barcode molecules comprises a first nucleic acid barcode sequence and is capable of coupling to a first analyte of the plurality of analytes; and (ii) a second individual barcode molecule of the plurality of barcode molecules comprises a second nucleic acid barcode sequence and is capable of coupling to a second analyte of the plurality of analytes, where the first analyte and the second analyte are different types of analytes.", "The system also can include a controller coupled to the partitioning unit, where the controller is programmed to: (i) direct the partitioning unit to provide the partition; subject the partition to conditions that are sufficient to: (1) synthesize a first nucleic acid molecule comprising at least a portion of the first nucleic acid barcode sequence or complement thereof; and (2) synthesize a second nucleic acid molecule comprising at least a portion of the second nucleic acid barcode sequence or complement thereof.", "Sequencing of the first nucleic acid molecule and the second nucleic acid molecule, or derivatives thereof, can characterize the first analyte or the second analyte.", "In some cases, the partitioning unit can provides a plurality of partitions comprising the partition.", "In some cases, the partitioning unit comprises a multi-well plate.", "In some cases, the partitioning unit comprises a plurality of channels, which may be microfluidic channels.", "The plurality of channels may come together to form at least one channel junction that provides the partition.", "In some cases, a partitioning unit may comprise a first (i) a first channel fluidically connected to the at least one channel junction and configured to provide a first fluid to the at least one channel junction; (ii) and a second channel fluidically connected to the at least one channel junction and configured to provide a second fluid, immiscible with the first fluid, to the at least one channel junction.", "In an example, then first channel may be configured to provide an aqueous phase comprising aqueous phase reagents (e.g., nucleic acids, including barcoded nucleic acids, labelling agents, beads, an agent that can degrade beads, amplification/primer extension reagents, sample nucleic acids, cells, cell lysis reagents, etc.)", "and the second channel may be configured to provide an oil phase comprising an oil (e.g., an oil comprising a fluorosurfactant) that is immiscible with the aqueous phase.", "Upon contact of the aqueous phase with the oil phases, aqueous phase droplets comprising aqueous phase reagents are generated.", "In various aspects, the partition or the given partition may comprise at least 1,000 barcode molecules, at least 2,500 barcode molecules at least 5,000 barcode molecules, at least 7,500 barcode molecules, at least 10,000 barcode molecules, at least 20,000 barcode molecules, at least 30,000 barcode molecules, at least 50,000 barcode molecules, at least 60,000 barcode molecules, at least 70,000 barcode molecules, at least 80,000 barcode molecules, at least 90,000 barcode molecules, at least 100,000 barcode molecules, at least 200,000 barcode molecules, at least 300,000 barcode molecules, at least 400,000 barcode molecules, at least 500,000 barcode molecules, at least 600,000 barcode molecules, at least 700,000 barcode molecules, at least 800,000 barcode molecules, at least 900,000 barcode molecules, at least 1,000,000 barcode molecules, at least 2,500,000 barcode molecules, at least 5,000,000 barcode molecules, at least 7,500,000 barcode molecules at least 10,000,000 barcode molecules, at least 50,000,000 barcode molecules, at least 100,000,000 barcode molecules or more.", "In various aspects, at least one of the first individual barcode molecule and the second individual barcode molecule may be coupled (e.g., via a covalent bond, via non-covalent interactions, via a labile bond, etc.)", "to a bead.", "In some cases, the bead comprises a gel bead and/or is degradable as described elsewhere herein.", "In methods described herein, the first or second barcode molecule can be released from the bead after a partition or partitions are provided.", "In some cases, release of a barcode molecule may occur prior to, simultaneous to, or following its use in barcoding a respective nucleic acid molecule.", "Where release happens after barcoding, barcoded constructs are initially coupled to the bead.", "Moreover, a partition may comprise an agent capable of degrading the bead.", "In some cases, such a reagent is a reducing agent that can reduce disulfide bonds of the bead and/or any disulfide linkages between species coupled to the bead and the bead itself.", "Moreover, in various aspects, the partition or a given partition can be any suitable partition such as a droplet among a plurality of droplets (e.g., droplets in an emulsion) or a well among a plurality of wells.", "Furthermore, in various aspects, the first nucleic acid barcode sequence and the second nucleic acid barcode sequence are identical.", "In various aspects, the first analyte or the second analyte can be a nucleic acid molecule, including any type of nucleic acid molecule described elsewhere herein.", "For example, the nucleic acid molecule may be genomic deoxyribonucleic acid (gDNA).", "In another example, the nucleic acid molecule is messenger ribonucleic acid (mRNA).", "Moreover, in various aspects, the first analyte or the second analyte is a labelling agent capable of coupling to a cell surface feature of a cell.", "The partition or the given partition can comprise the cell or one or more components of the cell (e.g., such as free cellular surface features remaining after cell lysis).", "In some cases, the partition or given partition comprises a single cell.", "The labelling agent can be any labelling agent, including a type of labelling agent described elsewhere herein including an antibody, an antibody fragment, a cell surface receptor binding molecule, a receptor ligand, a small molecule, a bi-specific antibody, a bi-specific T-cell engager, a T-cell receptor engager, a B-cell receptor engager, a pro-body, an aptamer, a monobody, an affimer, a darpin, a protein scaffold, an antigen, an antigen presenting particle and a major histocompatibility complex (MHC).", "Examples of cell surface features include a receptor, an antigen, a surface protein, a transmembrane protein, a cluster of differentiation protein, a protein channel, a protein pump, a carrier protein, a phospholipid, a glycoprotein, a glycolipid, a cell-cell interaction protein complex, an antigen-presenting complex, a major histocompatibility complex, a T-cell receptor, a B-cell receptor, a chimeric antigen receptor, a gap junction, an adherens junction and any other cell surface feature described elsewhere herein.", "In some cases, cells are incubated in bulk with one or more labelling agents prior to partitioning of cells.", "The one or more labelling agents can be chosen such that they are directed to particular cell surface features of interest in a given assay.", "Upon binding of the one or more labeling agents to respective cell surface features, where present, the cells can then be washed to remove unbound labelling agents and the resulting cells then subject to partitioning.", "Moreover, in some cases, the first individual barcode molecule or the second individual barcode molecule may be capable of coupling to the labelling agent via a third nucleic acid molecule coupled to the labelling agent.", "The third nucleic acid molecule can be coupled to the labelling agent and comprise a third nucleic acid barcode sequence that identifies the coupled labelling agent (and, thus, a cell surface feature to which the labelling agent is bound).", "In a primer extension reaction, the first individual barcode molecule or the second individual barcode molecule can be extended such that a complement of the third barcode sequence is added to the first or second individual barcode molecule.", "During sequencing, the first or second barcode sequence of these molecules can identify the partition from which the molecules were synthesized and, where a partition comprises a single cell, the third barcode sequence can associate a particular cell surface feature with that single cell.", "In various aspects, the first analyte and second analyte can be different types of nucleic acid molecules.", "For example, the first analyte may be a deoxyribonucleic acid molecule (e.g., gDNA) and the second analyte may be ribonucleic acid molecule (e.g., mRNA), such as, for example, a transcript.", "Where implemented, a cell's genomic DNA and also the cell's transcriptome can be analyzed and characterized.", "Moreover, where the first and second analytes are nucleic acid molecules, the first individual barcode molecule and/or the second individual barcode molecule may comprise a priming sequence capable of hybridizing to the first analyte and/or second analyte respectively.", "In addition to the first nucleic acid barcode molecule or the second nucleic acid barcode molecule, may also include a UMI sequence, that can be useful for identifying (and even quantifying) particular molecules that are barcoded within a given partition, as is described elsewhere herein.", "In an example, schematically depicted in FIG.", "46A, a partition (e.g., a droplet, a well or any other type of partition described herein) comprises a bead 4601, which is coupled (e.g., reversibly coupled) to barcoded oligonucleotides 4602 and 4603.The bead 4601 and barcoded oligonucleotides 4602 and 4603 are schematically depicted in FIG.", "46A.", "Barcoded oligonucleotide 4602 comprises a first nucleic acid barcode sequence and a poly-T priming sequence 4604 that can hybridize with the poly-A tail of an mRNA transcript.", "Barcoded oligonucleotide 4602 may also comprise a UMI sequence that can uniquely identify a given transcript.", "Barcoded oligonucleotide 4603 comprises a second nucleic acid barcode sequence and a random N-mer priming sequence 4605 that is capable of randomly hybridizing with gDNA.", "In this configuration, barcoded oligonucleotides 4602 and 4603 comprise the same nucleic acid barcode sequence, which permits association of downstream sequencing reads with the partition.", "In some cases, though, the first nucleic acid barcode sequence and the second nucleic acid barcode sequence are different.", "The partition also comprises a cell (not shown) and lysis agents that aid in releasing nucleic acids from the cell and can also include an agent (e.g., a reducing agent) that can degrade the bead and/or break a covalent linkage between the barcoded oligonucleotides 4602 and 4603 and bead 4601, releasing them into the partition.", "The released barcoded oligonucleotide 4602 can hybridize with mRNA released from the cell and the released barcoded oligonucleotide 4603 can hybridize with gDNA released from the cell.", "Barcoded constructs A and B can then be generated for each of the mRNA and barcoded oligonucleotide 4623 as described elsewhere herein, such as via the action of a polymerase (and/or reverse transcriptase) and/or primer extension.", "Barcoded construct A can comprises a sequence corresponding to the original barcode sequence from the bead and a sequence corresponding to a transcript from the cell.", "Barcoded construct B can comprise a sequence corresponding to the original barcode sequence from the bead and a sequence corresponding to genomic DNA from the cell.", "The barcoded constructs can then be released/removed from the partition and, in some cases, further processed to add any additional sequences.", "The resulting constructs are then sequenced, sequencing data processed, and the results used to characterize the mRNA and the gDNA from the cell.", "Analysis can be completed, for example, as described elsewhere herein.", "The information received from the characterization can then be used in a subsequent analysis of another cell in a partition.", "Moreover, barcoded oligonucleotides 4602 and 4603 can be designed to prime any particular type of nucleic acid, including those that are not derived from a cell.", "Moreover, the priming sequences shown in FIG.", "46A are for example purposes only and are not meant to be limiting.", "In various aspects, the first analyte may be a nucleic acid molecule (e.g., deoxyribonucleic acid (e.g., gDNA), ribonucleic acid (e.g., mRNA), a transcript) and the second analyte a labelling agent capable of coupling to a cell surface feature.", "In such a case, the first individual barcode molecule may comprise a priming sequence capable of hybridizing to the nucleic acid molecule and may also include a UMI sequence.", "Moreover, the second individual barcode molecule may comprise a priming sequence capable of hybridizing with a third nucleic acid molecule coupled to the labelling agent.", "As noted elsewhere herein, this third nucleic acid molecule can include a barcode sequence that identifies the labelling agent.", "It may also include a UMI sequence.", "The labelling agent can be any suitable labelling agent, including a type of example labelling agents described elsewhere herein, and may be targeted to any suitable cell surface feature to which it can selectively bind.", "Non-limiting examples of such cell surface features are provided elsewhere herein.", "Furthermore, in some cases, the partition comprises a cell having the cell surface feature and, in some cases, may comprise only one cell.", "In an example, schematically depicted in FIG.", "46B, a partition (e.g., a droplet, a well, a microcapsule, or any other type of partition described herein) comprises a bead 4611, which is coupled (e.g., reversibly coupled) to barcoded oligonucleotides 4612 and 4613.The bead 4611 and barcoded oligonucleotides 4612 and 4613 are schematically depicted in FIG.", "46B.", "Barcoded oligonucleotide 4612 comprises a first nucleic acid barcode sequence and a poly-T priming sequence 4614 that can hybridize with the poly-A tail of an mRNA transcript.", "Barcoded oligonucleotide 4612 may also comprise a UMI sequence that can uniquely identify a given transcript.", "Barcoded oligonucleotide 4613 comprises a second nucleic acid barcode sequence and a targeted priming sequence that is capable of specifically hybridizing with a barcoded oligonucleotide 4623 (via a complementary portion 4624 of barcoded oligonucleotide 4623 coupled to an antibody 4621 that is bound to the surface of a cell 4622.Barcoded oligonucleotide 4623 comprises a barcode sequence that uniquely identifies the antibody 4621 (and thus, the particular cell surface feature to which it is bound).", "In this configuration, barcoded oligonucleotides 4612 and 4613 comprise the same nucleic acid barcode sequence, which permit downstream association of barcoded nucleic acids with the partition.", "In some cases, though, the first nucleic acid barcode sequence and the second nucleic acid barcode sequence are different.", "Furthermore, barcoded labelling agents, including antibodies, may be produced by any suitable route, including via example coupling schemes described elsewhere herein.", "As shown in FIG.", "46B, the partition also comprises cell 4622, lysis agents that aid in releasing nucleic acids from the cell 4622 and can also include an agent (e.g., a reducing agent) that can degrade the bead and/or break a covalent linkage between the barcoded oligonucleotides 4612 and 4613 and bead 4611, releasing them into the partition.", "The released barcoded oligonucleotide 4612 can hybridize with mRNA released from the cell and the released barcoded oligonucleotide 4613 can hybridize with barcoded oligonucleotide 4623.Barcoded constructs A and B can then be generated for each of the mRNA and barcoded oligonucleotide 4623 as described elsewhere herein, such as via the action of a polymerase (and/or reverse transcriptase) and/or primer extension.", "Barcoded construct A may comprise a sequence corresponding to the original barcode sequence from the bead and a sequence corresponding to a transcript from the cell.", "Barcoded construct B may comprise a sequence corresponding to the original barcode sequence from the bead and an additional sequence corresponding to the barcode sequence coupled to the labelling agent.", "The barcoded constructs can then be released/removed from the partition and, in some cases, further processed to add any additional sequences.", "The resulting constructs are then sequenced, sequencing data processed, and the results used to characterize the mRNA and cell surface feature of the cell.", "Analysis, for example, can be completed as described elsewhere herein.", "The information received from the characterization can then be used in a subsequent analysis of another cell in a partition.", "Moreover, the priming sequences shown in FIG.", "46B are for example purposes only and are not meant to be limiting.", "In addition, the scheme shown in FIG.", "46B may also be used for concurrent analysis of genomic DNA and cell surface features.", "In some cases, the partition comprises only one cell.", "Furthermore, in various aspects, the first analyte may comprise a nucleic acid molecule with a nucleic acid sequence (mRNA, complementary DNA derived from reverse transcription of mRNA) encoding at least a portion of a V(D)J sequence of an immune cell receptor.", "Accordingly, a first barcode molecule may comprise a priming sequence that can prime such a nucleic acid sequence, as is described elsewhere herein.", "In some cases, the nucleic acid molecule with a nucleic acid sequence encoding at least a portion of a V(D)J sequence of an immune cell receptor is cDNA first generated from reverse transcription of the corresponding mRNA, using a poly-T containing primer.", "The cDNA that is generated can then be barcoded using a primer, comprising a barcode sequence (and optionally, a UMI sequence) that hybridizes with at least a portion of the cDNA that is generated.", "In some cases, a template switching oligonucleotide in conjunction a terminal transferase or a reverse transcriptase having terminal transferase activity may be employed to generate a priming region on the cDNA to which a barcoded primer can hybridize during cDNA generation.", "Terminal transferase activity can, for example, add a poly-C tail to a 3′ end of the cDNA such that the template switching oligonucleotide can bind via a poly-G priming sequence and the 3′ end of the cDNA can be further extended.", "The original mRNA template and template switching oligonucleotide can then be denatured from the cDNA and the barcoded primer comprising a sequence complementary to at least a portion of the generated priming region on the cDNA can then hybridize with the cDNA and a barcoded construct comprising the barcode sequence (and any optional UMI sequence) and a complement of the cDNA generated.", "Additional methods and compositions suitable for barcoding cDNA generated from mRNA transcripts including those encoding V(D)J regions of an immune cell receptor and/or barcoding methods and composition including a template switch oligonucleotide are described in U.S.", "Provisional Patent Application Ser.", "No.", "62/410,326, filed Oct. 19, 2016 and U.S.", "Provisional Patent Application Ser.", "No.", "62/490,546, filed Apr.", "26, 2017, both of which applications are herein incorporated by reference in their entireties.", "In one example, the scheme described elsewhere herein and schematically depicted in FIG.", "19 may be used for V(D)J analysis.", "V(D)J analysis may also be completed with the use of one or more labelling agents that bind to particular surface features of immune cells and are associated with barcode sequences as described elsewhere herein.", "In some cases, the one or more labelling agents comprise an MHC.", "In some cases, different types of analytes do not include labelling agents directed to separate cell surface features of a cell.", "Moreover, in various aspects, the first analyte may comprise a nucleic acid capable of functioning as a component of a gene editing reaction, such as, for example, clustered regularly interspaced short palindromic repeats (CRISPR)-based gene editing.", "Accordingly, the first barcode molecule may comprise a priming sequence that can prime such a nucleic acid sequence, as is described elsewhere herein.", "While the examples described with respect to FIGS.", "46A and 46B involve the analysis of two different types of analytes, these examples are not meant to be limiting.", "Any suitable number of analytes may be evaluated.", "Accordingly, in various aspects, there may be at least about 2, at least about 3, at least about 4, at least about 5, at least about 6, at least about 7, at least about 8, at least about 9, at least about 10, at least about 11, at least about 12, at least about 13, at least about 14, at least about 15, at least about 20, at least about 25, at least about 30, at least about 40, at least about 50, at least about 100 or more different analytes present in a partition, that can be subject to barcoded sequencing analysis.", "Higher number, multi-assay analysis can be completed by including primer species (one or more of which may be barcoded) that are capable of generating barcoded constructs and capable of specifically hybridizing with a particular analyte or oligonucleotide coupled to a labelling agent that is itself coupled to a particular analyte in the partition and subjecting the partition to suitable conditions for barcoding.", "An example reagent for multi-assay analysis is schematically depicted in FIG.", "46C.", "As shown in FIG.", "46C, a partition can include a bead 4651 that is coupled to barcoded primers that can each participate in an assay of a different analyte.", "The bead 4651 is coupled (e.g., reversibly coupled) a barcoded oligonucleotide 4652 that comprises a poly-T priming sequence 4654 for mRNA analysis and is also coupled (e.g., reversibly coupled) to barcoded oligonucleotide 4653 that comprises a random N-mer priming sequence 4655 for gDNA analysis.", "Moreover, bead 4651 is also coupled (e.g., reversibly coupled) to barcoded oligonucleotide 4656 that can specifically bind an oligonucleotide coupled to a labelling agent, via its targeted priming sequence 4657.Bead 4651 is also coupled to a barcoded oligonucleotide 4658 that can specifically bind a nucleic acid molecule that can function in a CRISPR assay (e.g., CRISPR/Cas9), via its targeted priming sequence 4659.In this example, each of the various barcoded primers comprises the same barcode sequence.", "Each barcoded oligonucleotide can be released from the bead 4651 within the partition and subject to conditions suitable for analysis of its respective analyte.", "In some cases, one or more of the analytes is associated with or derived from a cell, which itself, may be in the partition.", "In some cases, the partition comprises only one cell.", "Barcoded constructs A, B, C and D can be generated as described elsewhere herein and analyzed.", "Barcoded construct A may comprise a sequence corresponding to the barcode sequence from the bead and a DNA sequence corresponding to a target mRNA.", "Barcoded construct B may comprise a sequence corresponding to the barcode sequence from the bead and a sequence corresponding to genomic DNA.", "Barcoded construct C comprises a sequence corresponding to the barcode sequence from the bead and a sequence corresponding to barcode sequence associated with an antibody labelling agent.", "Barcoded construct D comprises a sequence corresponding to the barcode sequence from the bead and a sequence corresponding to a CRISPR nucleic acid.", "Each construct can be analyzed via sequencing and the results associated with the given cell from which the various analytes originated.", "While only four different barcoded constructs are shown in FIG.", "46C, barcoded (or even non-barcoded) constructs can be tailored for analyses of any given analyte associated with a nucleic acid and capable of binding with such a construct.", "The present disclosure provides computer control systems that are programmed to implement methods of the disclosure, i.e., protocols of the disclosure.", "For example, the present disclosure provides computer control systems programmed to implement method 2000 of the present disclosure.", "FIG.", "17 shows a computer system 1701 that is programmed or otherwise configured to implement methods of the disclosure including nucleic acid sequencing methods, cell surface feature identification methods, interpretation of nucleic acid sequencing data and analysis of cellular nucleic acids, such as RNA (e.g., mRNA), interpretation of nucleic acid sequencing data and analysis of nucleic acids derived from the characterization of cell surface features, and characterization of cells from sequencing data.", "The computer system 1701 can be an electronic device of a user or a computer system that is remotely located with respect to the electronic device.", "The electronic device can be a mobile electronic device.", "The computer system 1701 includes a central processing unit (CPU, also “processor” and “computer processor” herein) 1705, which can be a single core or multi core processor, or a plurality of processors for parallel processing.", "The computer system 1701 also includes memory or memory location 1710 (e.g., random-access memory, read-only memory, flash memory), electronic storage unit 1715 (e.g., hard disk), communication interface 1720 (e.g., network adapter) for communicating with one or more other systems, and peripheral devices 1725, such as cache, other memory, data storage and/or electronic display adapters.", "The memory 1710, storage unit 1715, interface 1720 and peripheral devices 1725 are in communication with the CPU 1705 through a communication bus (solid lines), such as a motherboard.", "The storage unit 1715 can be a data storage unit (or data repository) for storing data.", "The computer system 1701 can be operatively coupled to a computer network (“network”) 1730 with the aid of the communication interface 1720.The network 1730 can be the Internet, an internet and/or extranet, or an intranet and/or extranet that is in communication with the Internet.", "The network 1730 in some cases is a telecommunication and/or data network.", "The network 1730 can include one or more computer servers, which can enable distributed computing, such as cloud computing.", "The network 1730, in some cases with the aid of the computer system 1701, can implement a peer-to-peer network, which may enable devices coupled to the computer system 1701 to behave as a client or a server.", "The CPU 1705 can execute a sequence of machine-readable instructions, which can be embodied in a program or software.", "The instructions may be stored in a memory location, such as the memory 1710.The instructions can be directed to the CPU 1705, which can subsequently program or otherwise configure the CPU 1705 to implement methods of the present disclosure.", "Examples of operations performed by the CPU 1705 can include fetch, decode, execute, and writeback.", "The CPU 1705 can be part of a circuit, such as an integrated circuit.", "One or more other components of the system 1701 can be included in the circuit.", "In some cases, the circuit is an application specific integrated circuit (ASIC).", "The storage unit 1715 can store files, such as drivers, libraries and saved programs.", "The storage unit 1715 can store user data, e.g., user preferences and user programs.", "The computer system 1701 in some cases can include one or more additional data storage units that are external to the computer system 1701, such as located on a remote server that is in communication with the computer system 1701 through an intranet or the Internet.", "The computer system 1701 can communicate with one or more remote computer systems through the network 1730.For instance, the computer system 1701 can communicate with a remote computer system of a user.", "Examples of remote computer systems include personal computers (e.g., portable PC), slate or tablet PC's (e.g., Apple® iPad, Samsung® Galaxy Tab), telephones, Smart phones (e.g., Apple® iPhone, Android-enabled device, Blackberry®), or personal digital assistants.", "The user can access the computer system 1701 via the network 1730.Methods as described herein can be implemented by way of machine (e.g., computer processor) executable code stored on an electronic storage location of the computer system 1701, such as, for example, on the memory 1710 or electronic storage unit 1715.The machine executable or machine readable code can be provided in the form of software.", "During use, the code can be executed by the processor 1705.In some cases, the code can be retrieved from the storage unit 1715 and stored on the memory 1710 for ready access by the processor 1705.In some situations, the electronic storage unit 1715 can be precluded, and machine-executable instructions are stored on memory 1710.The code can be pre-compiled and configured for use with a machine having a processer adapted to execute the code, or can be compiled during runtime.", "The code can be supplied in a programming language that can be selected to enable the code to execute in a pre-compiled or as-compiled fashion.", "Aspects of the systems and methods provided herein, such as the computer system 1701, can be embodied in programming.", "Various aspects of the technology may be thought of as “products” or “articles of manufacture” typically in the form of machine (or processor) executable code and/or associated data that is carried on or embodied in a type of machine readable medium.", "Machine-executable code can be stored on an electronic storage unit, such as memory (e.g., read-only memory, random-access memory, flash memory) or a hard disk.", "“Storage” type media can include any or all of the tangible memory of the computers, processors or the like, or associated modules thereof, such as various semiconductor memories, tape drives, disk drives and the like, which may provide non-transitory storage at any time for the software programming.", "All or portions of the software may at times be communicated through the Internet or various other telecommunication networks.", "Such communications, for example, may enable loading of the software from one computer or processor into another, for example, from a management server or host computer into the computer platform of an application server.", "Thus, another type of media that may bear the software elements includes optical, electrical and electromagnetic waves, such as used across physical interfaces between local devices, through wired and optical landline networks and over various air-links.", "The physical elements that carry such waves, such as wired or wireless links, optical links or the like, also may be considered as media bearing the software.", "As used herein, unless restricted to non-transitory, tangible “storage” media, terms such as computer or machine “readable medium” refer to any medium that participates in providing instructions to a processor for execution.", "Hence, a machine readable medium, such as computer-executable code, may take many forms, including but not limited to, a tangible storage medium, a carrier wave medium or physical transmission medium.", "Non-volatile storage media include, for example, optical or magnetic disks, such as any of the storage devices in any computer(s) or the like, such as may be used to implement the databases, etc.", "shown in the drawings.", "Volatile storage media include dynamic memory, such as main memory of such a computer platform.", "Tangible transmission media include coaxial cables; copper wire and fiber optics, including the wires that comprise a bus within a computer system.", "Carrier-wave transmission media may take the form of electric or electromagnetic signals, or acoustic or light waves such as those generated during radio frequency (RF) and infrared (IR) data communications.", "Common forms of computer-readable media therefore include for example: a floppy disk, a flexible disk, hard disk, magnetic tape, any other magnetic medium, a CD-ROM, DVD or DVD-ROM, any other optical medium, punch cards paper tape, any other physical storage medium with patterns of holes, a RAM, a ROM, a PROM and EPROM, a FLASH-EPROM, any other memory chip or cartridge, a carrier wave transporting data or instructions, cables or links transporting such a carrier wave, or any other medium from which a computer may read programming code and/or data.", "Many of these forms of computer readable media may be involved in carrying one or more sequences of one or more instructions to a processor for execution.", "The computer system 1701 can include or be in communication with an electronic display screen 1735 that comprises a user interface (UI) 1740 for providing, for example, results of nucleic acid sequencing, analysis of nucleic acid sequencing data, characterization of nucleic acid sequencing samples, cell characterizations, etc.", "Examples of UI's include, without limitation, a graphical user interface (GUI) and web-based user interface.", "The system 1701 may comprise an electronic display screen 1735 comprising a user interface 1740 that displays a graphical element that is accessible by a user to execute a protocol per the methods described herein, (e.g.", "to characterize cells), and a computer processor coupled to the electronic display screen and programmed to execute the protocol upon selection of the graphical element by the user.", "Methods and systems of the present disclosure can be implemented by way of one or more algorithms.", "An algorithm can be implemented by way of software upon execution by the central processing unit 1705.The algorithm can, for example, initiate nucleic acid sequencing, process nucleic acid sequencing data, interpret nucleic acid sequencing results, characterize nucleic acid samples, characterize cells, etc.", "Barcoded oligonucleotides as described elsewhere herein may be generated in any suitable manner and comprise one or more sequences in addition to a barcode sequence.", "As noted elsewhere herein, one such sequence can be a priming sequence that can aid in barcoding analytes.", "Moreover, a barcoded oligonucleotide may also comprise one or more additional functional sequences that may, for example, aid in rendering the barcoded oligonucleotide compatible with a given sequencing platform (e.g., functional sequences may be flow cell adaptor immobilization sequences (such as, for example, P7 and P5 from an Illumina platform), sequencing primer binding site sequences (such as, for example, R1 from an Illumina platform), and other priming sites for downstream amplification, such as, for example, a Nextera functional sequence or a TruSeq functional sequence.", "In some cases, barcoded oligonucleotides are coupled to beads and beads may comprise oligonucleotides having a first type functional sequence at a given position and oligonucleotides having a second, different type of functional sequence at the given position.", "An example is depicted in FIG.", "50A.", "As shown in FIG.", "50A, a bead may be coupled to oligonucleotides comprising a TruSeq functional sequence and also to oligonucleotides comprising a Nextera functional sequence.", "Onto each of these sequences additional sequences can be added to generate a full oligonucleotide also comprising a nucleic acid barcode sequence, an optional UMI sequence and a priming sequence.", "Attachment of these sequences can be via ligation (including via splint ligation as is described in U.S. Patent Publication No.", "20140378345, which is herein incorporated by reference in its entirety) or any other suitable route.", "Sequences of example barcoded oligonucleotides comprising a TruSeq functional group are shown in FIG.", "50B and sequences of example barcoded oligonucleotides comprising a Nextera functional group are shown in FIG.", "50C.", "Each of the example barcoded oligonucleotides shown in FIG.", "50B and FIG.", "50B (top sequence for each construct) are shown hybridized with splint sequences (bottom sequence for each construct) that can be helpful in constructing complete barcoded oligonucleotides.", "In some aspects, methods provided herein may also be used to prepare polynucleotide contained within cells in a manner that enables cell-specific information to be obtained.", "The methods enable detection of genetic variations (e.g., SNPs, mutations, indels, copy number variations, transversions, translocations, inversions, etc.)", "from very small samples, such as from samples comprising about 10-100 cells.", "In some cases, about 1, 5, 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 cells may be used in the methods described herein.", "In some cases, at least about 1, 5, 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 cells may be used in the methods described herein.", "In other cases, at most about 5, 10, 20, 30, 40, 50, 60, 70, 80, 90 or 100 cells may be used in the methods described herein.", "In an example, a method comprises partitioning a cellular sample (or crude cell extract) such that at most one cell (or extract of one cell) is present per partition, lysing the cells, fragmenting the polynucleotides contained within the cells by any of the methods described herein, attaching the fragmented polynucleotides to barcodes, pooling, and sequencing.", "The barcodes and other reagents may be contained within a microcapsule.", "These microcapsules may be loaded into a partition (e.g., a microwell, a droplet) before, after, or concurrently with the loading of the cell, such that each cell is contacted with a different microcapsule.", "This technique may be used to attach a unique barcode to polynucleotides obtained from each cell.", "The resulting tagged polynucleotides may then be pooled and sequenced, and the barcodes may be used to trace the origin of the polynucleotides.", "For example, polynucleotides with identical barcodes may be determined to originate from the same cell, while polynucleotides with different barcodes may be determined to originate from different cells.", "The methods described herein may be used to detect the distribution of oncogenic mutations across a population of cancerous tumor cells.", "For example, some tumor cells may have a mutation, or amplification, of an oncogene (e.g., HER2, BRAF, EGFR, KRAS) in both alleles (homozygous), others may have a mutation in one allele (heterozygous), and still others may have no mutation (wild-type).", "The methods described herein may be used to detect these differences, and also to quantify the relative numbers of homozygous, heterozygous, and wild-type cells.", "Such information may be used, for example, to stage a particular cancer and/or to monitor the progression of the cancer and its treatment over time.", "In some examples, this disclosure provides methods of identifying mutations in two different oncogenes (e.g., KRAS and EGFR).", "If the same cell comprises genes with both mutations, this may indicate a more aggressive form of cancer.", "In contrast, if the mutations are located in two different cells, this may indicate that the cancer is more benign, or less advanced.", "Examples Example I: Cellular RNA Analysis Using Emulsions In an example, reverse transcription with template switching and cDNA amplification (via PCR) is performed in emulsion droplets with operations as shown in FIG.", "9A.", "The reaction mixture that is partitioned for reverse transcription and cDNA amplification (via PCR) includes 1,000 cells or 10,000 cells or 10 ng of RNA, beads bearing barcoded oligonucleotides/0.2% Tx-100/5× Kapa buffer, 2× Kapa HS HiFi Ready Mix, 4 μM switch oligo, and Smartscribe.", "Where cells are present, the mixture is partitioned such that a majority or all of the droplets comprise a single cell and single bead.", "The cells are lysed while the barcoded oligonucleotides are released from the bead, and the poly-T segment of the barcoded oligonucleotide hybridizes to the poly-A tail of mRNA that is released from the cell as in operation 950.The poly-T segment is extended in a reverse transcription reaction as in operation 952 and the cDNA is amplified as in operation 954.The thermal cycling conditions are 42° C. for 130 minutes; 98° C. for 2 min; and 35 cycles of the following 98° C. for 15 sec, 60° C. for 20 sec, and 72° C. for 6 min.", "Following thermal cycling, the emulsion is broken and the transcripts are purified with Dynabeads and 0.6×SPRI as in operation 956.The yield from template switch reverse transcription and PCR in emulsions is shown for 1,000 cells in FIG.", "13A and 10,000 cells in FIG.", "13C and 10 ng of RNA in FIG.", "13B (Smartscribe line).", "The cDNAs from RT and PCR performed in emulsions for 10 ng RNA is sheared and ligated to functional sequences, cleaned up with 0.8×SPRI, and is further amplified by PCR as in operation 958.The amplification product is cleaned up with 0.8×SPRI.", "The yield from this processing is shown in FIG.", "13B (SSII line).", "Example II: Cellular RNA Analysis Using Emulsions In another example, reverse transcription with template switching and cDNA amplification (via PCR) is performed in emulsion droplets with operations as shown in FIG.", "9A.", "The reaction mixture that is partitioned for reverse transcription and cDNA amplification (via PCR) includes Jurkat cells, beads bearing barcoded oligonucleotides/0.2% TritonX-100/5× Kapa buffer, 2× Kapa HS HiFi Ready Mix, 4 μM switch oligo, and Smartscribe.", "The mixture is partitioned such that a majority or all of the droplets comprise a single cell and single bead.", "The cells are lysed while the barcoded oligonucleotides are released from the bead, and the poly-T segment of the barcoded oligonucleotide hybridizes to the poly-A tail of mRNA that is released from the cell as in operation 950.The poly-T segment is extended in a reverse transcription reaction as in operation 952 and the cDNA is amplified as in operation 954.The thermal cycling conditions are 42° C. for 130 minutes; 98° C. for 2 min; and 35 cycles of the following 98° C. for 15 sec, 60° C. for 20 sec, and 72° C. for 6 min.", "Following thermal cycling, the emulsion is broken and the transcripts are cleaned-up with Dynabeads and 0.6×SPRI as in operation 956.The yield from reactions with various cell numbers (625 cells, 1,250 cells, 2,500 cells, 5,000 cells, and 10,000 cells) is shown in FIG.", "14A.", "These yields are confirmed with GADPH qPCR assay results shown in FIG.", "14B.", "Example III: RNA Analysis Using Emulsions In another example, reverse transcription is performed in emulsion droplets and cDNA amplification is performed in bulk in a manner similar to that as shown in FIG.", "9C.", "The reaction mixture that is partitioned for reverse transcription includes beads bearing barcoded oligonucleotides, 10 ng Jurkat RNA (e.g., Jurkat mRNA), 5× First-Strand buffer, and Smartscribe.", "The barcoded oligonucleotides are released from the bead, and the poly-T segment of the barcoded oligonucleotide hybridizes to the poly-A tail of the RNA as in operation 961.The poly-T segment is extended in a reverse transcription reaction as in operation 963.The thermal cycling conditions for reverse transcription are one cycle at 42° C. for 2 hours and one cycle at 70° C. for 10 min.", "Following thermal cycling, the emulsion is broken and RNA and cDNAs are denatured as in operation 962.A second strand is then synthesized by primer extension with a primer having a biotin tag as in operation 964.The reaction conditions for this primer extension include cDNA as the first strand and biotinylated extension primer ranging in concentration from 0.5-3.0 μM.", "The thermal cycling conditions are one cycle at 98° C. for 3 min and one cycle of 98° C. for 15 sec, 60° C. for 20 sec, and 72° C. for 30 min.", "Following primer extension, the second strand is pulled down with Dynabeads MyOne Streptavidin C1 and T1, and cleaned-up with Agilent SureSelect XT buffers.", "The second strand is pre-amplified via PCR as in operation 965 with the following cycling conditions—one cycle at 98° C. for 3 min and one cycle of 98° C. for 15 sec, 60° C. for 20 sec, and 72° C. for 30 min.", "The yield for various concentrations of biotinylated primer (0.5 μM, 1.0 μM, 2.0 μM, and 3.0 μM) is shown in FIG.", "15.Example IV: RNA Analysis Using Emulsions In another example, in vitro transcription by T7 polymerase is used to produce RNA transcripts as shown in FIG.", "10.The mixture that is partitioned for reverse transcription includes beads bearing barcoded oligonucleotides which also include a T7 RNA polymerase promoter sequence, 10 ng human RNA (e.g., human mRNA), 5× First-Strand buffer, and Smartscribe.", "The mixture is partitioned such that a majority or all of the droplets comprise a single bead.", "The barcoded oligonucleotides are released from the bead, and the poly-T segment of the barcoded oligonucleotide hybridizes to the poly-A tail of the RNA as in operation 1050.The poly-T segment is extended in a reverse transcription reaction as in operation 1052.The thermal cycling conditions are one cycle at 42° C. for 2 hours and one cycle at 70° C. for 10 min.", "Following thermal cycling, the emulsion is broken and the remaining operations are performed in bulk.", "A second strand is then synthesized by primer extension as in operation 1054.The reaction conditions for this primer extension include cDNA as template and extension primer.", "The thermal cycling conditions are one cycle at 98° C. for 3 min and one cycle of 98° C. for 15 sec, 60° C. for 20 sec, and 72° C. for 30 min.", "Following this primer extension, the second strand is purified with 0.6×SPRI.", "As in operation 1056, in vitro transcription is then performed to produce RNA transcripts.", "In vitro transcription is performed overnight, and the transcripts are purified with 0.6×SPRI.", "The RNA yields from in vitro transcription are shown in FIG.", "16.Example V: Delivering Lysis Agent to a Partition Using Gel Beads A lysis agent is introduced into the partition (GEM) via the gel bead suspension (GBS).", "The lysis agent is a surfactant that causes wetting failures (uncontrolled droplet formation) to occur when its concentration in the GBS exceeds a threshold.", "A larger gel bead can be used to increase the in-partition concentration of the lysis agent, without increasing the in-GBS concentration (to avoid wetting failures) and without decreasing the total volume of the partition (which may not be reduced without decreasing the sensitivity of the assay) (FIG.", "36A).", "Alternatively, a larger gel bead can be used to increase the volume of the partition (which increases the sensitivity of the assay) and preserve the existing in-partition lysis agent concentration without increasing the in-GBS concentration.", "The size of the gel bead can also affect how cells are partitioned.", "By replacing a portion of the sample volume (Z2) with the gel bead suspension volume (Z1), larger gel beads decrease the in-partition concentration of cells, which, according to Poisson statistics, results in a lower probability of the unfavorable encapsulation of more than one cell per partition (FIG.", "36B).", "Example VI: Producing CD3 Protein Conjugated with Short ssDNA Molecules The CD3 protein and the ssDNA molecule are first activated for click chemistry reaction.", "The CD3 protein is activated with 5-(methacrylamido)tetrazole (MTet) and the ssDNA molecule is activated with trans-cyclooctene (TCO).", "The ssDNA molecule comprises a biotin group.", "The activated CD3 protein and ssDNA molecule are mixed for conjugation by click chemistry reactions.", "The ssDNA molecule concentration is 5 times excess over the CD3 protein concentration to avoid multiple barcode copies conjugating on the same protein molecule.", "In some cases, the ssDNA concentration is 10 times excess over the CD3 protein to maximize barcode attachment.", "A biotin group may also be incorporated in the activated CD3-ssDNA conjugate for purification.", "The CD3 protein and ssDNA conjugate is purified and tested as shown in FIG.", "37.Example VII: Labelling Jurkat Cells with Human CD3 and Mouse CD3 The impact of DNA conjugation on the binding of CD3 on Jurkat cells is tested.", "Human CD3 (hCD3, MCA463) and mouse CD3 (mCD3, MCA500) are incubated with AF488-NHS, where the concentration of AF499-NHS is 1×, 2×, 5×, and 10× excess over the CD3 protein, in order to generate labeled CD3, where the AF999 is coupled to an amine of the CD3.The conjugated hCD3 and mCD3 are incubated with Jurkat cells.", "Unbound CD3 proteins are washed away.", "The fluorescence signals from the labeled cells are determined (FIG.", "38).", "The fluorescent signals are normalized by comparing to commercial Jurkat cells control.", "The data show that Jurkat cells specifically bind to hCD3 over mCD3, indicating that the conjugation of dye/DNA does not affect the binding of CD3 proteins with Jurkat cells.", "Blocking reagents (e.g., FBS, 5% BSA) may be added to improve specificity.", "Example VIII: Conjugating a DNA Barcode to IgG of an Antibody An antibody is incubated with Methyltetrazine-PEG5-NHS Ester at room temperature for 1 hour and desalted.", "A DNA barcode of about 65 nt long is incubated with TCO-PEG4-NHS Ester at room temperature for an hour and desalted.", "The resulting antibody and DNA barcode are incubated at room temperature for 2 hours for conjugation.", "FIG.", "39A shows the conjugation strategy.", "The conjugated antibody-DNA complex is subject to protein gel analysis.", "As shown in FIG.", "39B, protein gel shifts of about 20 kDa indicates successful conjugation of the DNA barcode to IgG of the antibody.", "Multiple viable chemistries for primary antibody barcoding are validated (e.g., mTet, dibenzocyclooctyne (DBCO), SiteClick).", "The conjugated antibody-DNA complex is incubated with cells for labelling.", "Example IX: Conjugating Oligonucleotides to Antibodies Using Antibody-Binding Proteins Antibody-binding proteins Protein X (Protein A or Protein G) are functionalized with dibenzocyclooctyne-N-hydroxysuccinimidyl ester (DBCO-NHS).", "Fluorescein amidite (FAM)-labeled oligoX22-azide (3eq) is used as the oligonucleotides to be conjugated with the antibody-binding proteins.", "The functionalized antibody-binding proteins and the oligonucleotides are conjugated as shown in FIG.", "40.The degree of conjugation between the dibenzocyclooctyne (DBCO) and Protein G may be controlled based on Gong et al., Simple Method To Prepare Oligonucleotide-Conjugated Antibodies and Its Application in Multiplex Protein Detection in Single Cells.", "Bioconjugate Chem., 2016, which is incorporated herein by reference in its entirety.", "Degree of DBCO incorporation may be controlled by adjusting input DBCO-NHS concentration as shown in FIG.", "41.Moreover, the degree of conjugation may be controlled through oligonucleotide equivalence as shown in FIG.", "42.A crude protein-oligonucleotide conjugation reaction was analyzed by gel electrophoresis (SDS-PAGE) to determine conjugation efficiency and the number of oligonucleotides conjugated.", "Increase of oligonucleotide equivalence with respect to the protein leads to a higher degree of conjugation as shown in FIG.", "42.Because the oligonucleotide contains a fluorescent molecule, the unused oligonucleotide can easily be visualized with in-gel fluorescence imaging (black panel in FIG.", "42).", "The oligonucleotide-Protein X conjugates are incubated with CD47 antibodies to form labeled antibodies.", "The labeled antibodies are incubated with Jurkat cells and washed twice to make labeled cells.", "The labelling of cells is measured by fluorescence signals using flow cytometry (FIG.", "43).", "Example X: Producing a Bead Coupled with Oligonucleotides with Different Primer Sequences This example shows a method for producing a bead coupled with oligonucleotides with different primer sequences.", "The work flow is shown in FIG.", "44.A barcode sequence 4421 is ligated to a sequence primer R1 4411 coupled to a bead.", "The R1 primer 4411 and barcode sequence 4421 form the backbone 4420 of the oligonucleotides on the bead.", "A plurality of backbone oligonucleotides 4420 are coupled to the same bead.", "Different primers sequences are then ligated to the backbone oligonucleotides 4420.The primers include a poly-T primer 4431 that targets the poly-A of mRNA molecules.", "The primers also include a target specific primer, e.g., an antibody target primer that binds to a barcode on an antibody.", "After the second ligation, the bead comprises oligonucleotides with poly-T primers (4430) and oligonucleotides with antibody target primers (4440).", "The resulting product from the method is a bead coupled with a plurality of oligonucleotides (FIG.", "45A).", "All of the oligonucleotides comprise the same backbone.", "Some of the oligonucleotide comprises poly-T primers and some comprises the antibody target primers.", "Beads with 0%, 5%, 15%, and 25% of coupled oligonucleotides containing antibody target primers are analyzed by gel electrophoresis (FIG.", "45B) Example XI: Barcoding Antibody Labelling Agents and Cell Surface Feature Analysis In a first set of experiments, a barcoded oligonucleotide comprising an azide functional group and a FAM dye was conjugated to a Protein G labelling agent using a click chemistry reaction scheme.", "The barcoded oligonucleotide included a barcode sequence that may be used to identify Protein G and also a sequence that may be used as a priming site.", "Protein G was mixed with increasingly higher molar equivalents of DBCO-NHS (0×, 1×, 2×, 4× and 6×) in a series of mixtures.", "The DBCO-NHS was used to activate amine groups to become reactive to azide.", "Also included were varying equivalents of azide oligonucleotide to DBCO (0×, 1×, 1.5× and 2×) in the mixtures.", "Reactions were then allowed to proceed for 4 hours and the reaction mixtures evaluated with gel electrophoresis on a 4-12% bis-Tris gel.", "The results of the analysis are graphically depicted in FIG.", "47.Protein G having up to 6 oligonucleotides linked were observed.", "The various labeled Protein G moieties were then mixed with CD47 antibody to bind the labeled Protein G moieties to CD47 antibodies.", "The resulting Protein G-CD47 complexes were then incubated with 293T cells such that the complexes may bind CD47 on the surface of cells.", "Cells were washed to remove unbound complex and then subject to flow cytometry to observe binding of antibodies via the oligo-bound FAM dye.", "Results of flow cytometry are graphically depicted in FIG.", "48.Next, labeled cells were mixed with a bead coupled to an oligonucleotide comprising a nucleic acid barcode sequence, a UMI and a poly-T sequence capable of binding the poly-A sequence of mRNA transcripts in a cell.", "Also included was a barcoded primer having a priming sequence capable of specifically hybridizing the barcoded oligonucleotide coupled to CD47 antibodies via the barcoded oligonucleotide's priming site.", "The mixture was then partitioned into a droplets in an emulsion.", "The emulsion was then subject to conditions suitable for priming sequences to hybridize with their respective targets (mRNA or barcoded antibody oligonucleotide) and for extension of primers via the action of a polymerase or reverse transcriptase.", "Extension generated barcoded constructs.", "Following reactions, the emulsion was broken.", "Barcoded transcript constructs still attached to beads were removed by removing beads and the supernatant subject to 2X SPRI separation to recover the ˜110 bp antibody barcode.", "The recovered products were then analyzed, with results shown in FIGS.", "49A and 49B.", "Example XII: Coupling of Barcodes In a bulk experiment, two oligonucleotides shown in FIG.", "51A, 5101 and 5102, were linked together via extension reactions.", "Oligonucleotide 5101 represented an oligonucleotide comprising a barcode sequence that may be used to identify a partition comprising the oligonucleotide 5101 and oligonucleotide 5102 represented an oligonucleotide comprising a barcode sequence that may be used to identify a labelling agent, such as an antibody coupled to oligonucleotide 5102.Oligonucleotide 5102 also included a FAM dye and a 3′ reverse complement of a template switch oligonucleotide spacer-rGrGrG region included on oligonucleotide 5101.In the experiment, 50 nM AbBC of oligonucleotide 5102 was mixed with oligonucleotide 5101 in two separate mixtures.", "Included in the mixture were reagents for conducting a primer extension reaction, including one of two reverse transcriptases capable of facilitating a primer extension reaction and dNTPs.", "Extension products were then analyzed via capillary electrophoresis.", "The results of the experiment are graphically shown in FIG.", "51B.", "As shown, expected extension products having both a sequence corresponding to the barcode sequence of oligonucleotide 5101 (or a complement of the barcode sequence) and a sequence corresponding to the barcode sequence of oligonucleotide 5102 (or a complement of the barcode sequence) were detected.", "These results confirm that the reverse transcriptases tested may be used to generate extension products having sequences corresponding to both barcode sequences of oligonucleotides 5101 and 5102.Example XIII: Single-Cell Barcode Behavior Anti-CD47 and Anti-CD99 antibodies were obtained and both types were coupled to an oligonucleotide comprising a barcode sequence that was suitable for identifying its respective antibody and also comprising a unique molecular identification (UMI) sequence and a template switch oligonucleotide reverse complement sequence (e.g., C C C).", "The antibody-oligonucleotide constructs were generated by linking the oligonucleotides to protein G and then binding the protein G-oligonucleotide constructs to the antibodies.", "The oligonucleotides were linked to protein G by modifying protein G with a single cysteine residue and linking it to oligonucleotides via the cysteine residue.", "Protein G also included a Hisx6 tag (SEQ ID NO: 40) which may be used to separate unconjugated oligonucleotides from those coupled to Protein G. Sample data from gel electrophoresis analysis of generated constructs is shown in FIG.", "52A.", "The lanes in FIG.", "52A show expression of a cysteine-containing protein G antibody binding protein.", "The culture lane depicts a homogenized cell culture, the flow through lane depicts is all proteins that did not bind to a nickel-NTA column, and the two elution lanes are eluted purified protein G. Jurkat cells were then incubated with antibody-oligonucleotide constructions to bind antibodies to the surface of cells via their respective cell surface feature targets.", "The cells were then partitioned into aqueous droplets in an emulsion, along with beads linked to oligonucleotides comprising a barcode sequence, a UMI sequence, a priming sequences capable of hybridizing with antibody-bound oligonucleotides (e.g., primer sequence include a template switch sequence, such as rGrGrG).", "A reducing agent, capable of disrupting disulfide linkages of beads and linkages between beads and its oligonucleotides was also included in the partitions.", "The reducing agent released the bead's oligonucleotides and the droplets were then subjected to conditions suitable for hybridizing the previously bead-bound oligonucleotides to cell-bound antibody oligonucleotides via an interaction of sequences of the two oligonucleotides, including via an rGrGrG/CCC interaction.", "While a particular sequence is shown, hybridization may be achieved via any constant sequence at the ends of the two oligonucleotides.", "The two hybridized oligonucleotides were then extended in primer extension reactions to generate constructs comprising sequences corresponding to both bead oligonucleotide and antibody barcode sequences, similar to the example scheme shown in FIG.", "52B (panel I).", "The emulsion was then broken, the extended products further processed and then subject to sequencing.", "Sequencing results for Jurkat+CD47 and Jurkat+CD47/CD99 runs are graphically depicted in panels I and II, respectively, of FIG.", "53A and tabulated in FIG.", "53B.", "The data shown in FIG.", "53A and FIG.", "53B indicate that the antibody-oligonucleotide constructions comprising barcode sequences were able to show single cell behavior, as evidenced, for example, by an approximately 2-log enrichment of antibody-oligonucleotide UMIs in bead-originating barcode constructs corresponding to cells.", "Example XIV: Antibody Barcode Staining Parameters Various parameters associated with methods described herein were evaluated in the context of their effects on antibody-barcode construct binding, including a reverse transcription deactivation process and the concentration of reducing agent in partitions (e.g., reducing agent used to degrade barcoded beads as described elsewhere herein).", "Reverse transcription can be deactivated by elevating the temperature of reverse transcription reaction mixtures to relatively high temperatures (a “heat kill”).", "However, such high temperatures may result in antibody-barcode constructs precipitating out of reaction mixtures, resulting in an inability to bind to cells.", "Various anti-CD3 barcode construct samples were tested against cells, with some samples subject to heat kill and others not subjected to heat kill.", "Sequencing data for the experiments is tabulated in FIG.", "54.As shown in FIG.", "54, a number of sequencing metrics are improved when no heat kill is used, including reads mapped confidently and complexity.", "Moreover, high concentrations of reducing agents can also degrade antibodies used to label cell-surface features.", "Accordingly, the effect of lower reducing agent (e.g., DTT) concentration by 10-fold was tested on overall efficiency of reverse transcription in partitions.", "As show in FIG.", "55, traces are similar for all samples tested (22 mM DTT vs. 2.2 mM DTT), suggesting that reverse transcription, as described elsewhere herein, can effectively proceed at substantially reduced DTT concentrations.", "In another experiment, 0.15 mM DTT was also shown to be effective.", "While some embodiments of the present invention have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only.", "It is not intended that the invention be limited by the specific examples provided within the specification.", "While the invention has been described with reference to the aforementioned specification, the descriptions and illustrations of the embodiments herein are not meant to be construed in a limiting sense.", "Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the invention.", "Furthermore, it shall be understood that all aspects of the invention are not limited to the specific depictions, configurations or relative proportions set forth herein which depend upon a variety of conditions and variables.", "It should be understood that various alternatives to the embodiments of the invention described herein may be employed in practicing the invention.", "It is therefore contemplated that the invention shall also cover any such alternatives, modifications, variations or equivalents.", "It is intended that the following claims define the scope of the invention and that methods and structures within the scope of these claims and their equivalents be covered thereby." ] ]
Patent_15875899
[ [ "SYSTEM AND METHOD FOR PROVIDING A FOOD RECOMMENDATION BASED ON FOOD SENSITIVITY TESTING", "Systems, methods, and computer-readable non-transitory storage medium for protecting a patient from adverse reaction to a food ingredient are provided.", "The system derives a first confidence level data indicating a probability of the patient having adverse reaction to the food ingredient from the patient's medical data.", "The system obtains food ingredient information comprising a second confidence level data indicating a probability of the food ingredient existing in the food item.", "Based on the first and second confidence level data, the system generates a safety level for the patient to consume the food item.", "Then, the system can cause a machine to take an action associated with the food item according to the generated safety level or display a recommendation to the patient." ], [ "1.A system for protecting a patient from adverse reaction to a food ingredient, wherein the system is communicatively coupled with a machine, the system comprising: a memory to store program instructions; and a processor, operatively coupled with the memory to execute the program instructions to cause the processor to: derive, from medical data, a first confidence level data indicating a probability of the patient having adverse reaction to the food ingredient; receive food ingredient information comprising a second confidence level data indicating a probability of the food ingredient existing in the food item; generate, based on the first and second confidence level data, a safety level for the patient to consume the food item; and cause the machine to take an action associated with the food item according to the generated safety level.", "2.The system of claim 1, wherein the program further causes the processor to derive first confidence level data from a testing of the patient for a disease using a food preparation having a reference value, wherein the reference value comprises an average discriminatory p-value of ≤0.15 for individuals not diagnosed with or suspected of having the same disease.", "3.The system of claim 1, wherein the program further causes the processor to derive first confidence level data from a group data of individuals diagnosed of same disease with the patient, wherein the group data includes a reference value of a food preparation with an average discriminatory p-value of ≤0.15 for individuals not diagnosed with or suspected of having the same disease.", "4.The system of claim 1, wherein the program further causes the processor to derive first confidence level data from a group experience data diagnosed of same disease.", "5.The system of claim 1, wherein the program further causes the processor to derive the first confidence level from the patient's experience history.", "6.The system of claim 3, wherein the group data comprises a plurality of sensitivity ratings associated with the food preparation.", "7.The system of claim 3, the program further causes the processor to: identify a pattern of the group data; correlate the pattern with a probability of the patient having adverse reaction to the food ingredient; and automatically update the first confidence level based on patterns of the group data.", "8.The system of claim 1, wherein the program further causes the processor to: obtain, from a sensor device, sensor data representing a food item; and derive, based on the sensor data, food ingredient information comprising a second confidence level data indicating a probability of the food ingredient existing in the food item 9.The system of claim 1, wherein the program further causes the processor to derive the second confidence level data of a food ingredient from group data comprising experience history of individuals having adverse reaction to the food item.", "10.The system of claim 9, the program further causes the processor to: identify a pattern of the group data; correlate the pattern with a probability of the food ingredient existing in the food item; and automatically update the second confidence level based on patterns of the group data.", "11.The system of claim 1, wherein the program further causes the processor to determine the safety level low when the processor determines at least one of the first and second confidence level is high.", "12.The system of claim 1, wherein the program further causes the processor to determine the safety level high when the processor determines both of the first and second confidence levels are low.", "13.The system of claim 1, wherein the machine is a vending machine and the program further causes the processor to cause the vending machine to fail to vend the food item when the processor determines the safety level low.", "14.The system of claim 1, wherein the machine is a self check-out kiosk, and the program further causes the processor to cause the self check-out kiosk to fail to check out the food item when the processor determines the safety level low.", "15.The system of claim 1, wherein the machine is a self-order machine, and the program further causes the processor to cause the self-order machine to fail to process the order of the food item when the processor determines the safety level low.", "16.The system of claim 1, wherein the machine comprises a smart phone or a smart watch.", "17.The system of claim 16, wherein the program further causes the processor to cause the machine to display a notification associated with risk of an adverse reaction to, and/or a recommendation not to consume, the food item when the processor determines the safety level low.", "18.The system of claim 1, wherein the machine comprises a tablet or a computer.", "19.The system of claim 18, wherein the program further causes the processor to cause the machine to display a notification associated with risk of an adverse reaction to, and/or a recommendation not to consume, the food item when the processor determines the safety level low.", "20.The system of claim 1, wherein the action comprises at least one of restrict access to, display a notification associated with risk of an adverse reaction to, or display a recommendation not to consume." ], [ "<SOH> BACKGROUND <EOH>The following description includes information that may be useful in understanding the present disclosure.", "It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.", "Food sensitivities may result in the display of many different types of symptoms and sicknesses associated with one or more food groups or ingredients.", "These symptoms or adverse reactions may arise for a wide variety of reasons, making them complex and oftentimes difficult to treat.", "The cause-effect relationship between food triggers and the resulting symptoms/adverse reactions is not well known, and has not been extensively studied in the medical community.", "Moreover, meaningful diagnostic methods for determining food sensitivities with respect to some food types have not been well established.", "With the diagnostics tests that are available, the quality of the test results is generally poor.", "Typically, problems associated with these tests—as well as the labs interpreting the test results—include high false positive rates, high intra-patient variability, and inter-laboratory variability.", "Accurately identifying the various food ingredients present in food items presents another problem.", "Ambiguous and inconsistent naming conventions amongst food ingredients, and between different food items, can present confusion to the consumer.", "For example, if a patient does not know with any degree of certainty that a specific food item contains an ingredient that is a trigger for food sensitivity, detection of the ingredients from a food label becomes moot.", "Similarly, if the food product description on the packaging is ambiguous (e.g., “crab product” versus ‘soft shell crab’, ‘crab imitation meat’, ‘lobster’, etc.", "), false positive and false negative alerts to the patient may be generated.", "All publications herein are incorporated by reference to the same extent as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference.", "Where a definition or use of a term in an incorporated reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein applies and the definition of that term in the reference does not apply.", "Thus, there is still a need for improved systems and methods for providing food recommendations or improved food access systems and methods based on a patient's food sensitivity testing and available product information." ], [ "<SOH> SUMMARY <EOH>The subject matter described herein provides systems, methods, and computer-readable non-transitory storage medium for protecting a patient from adverse reaction to a food ingredient.", "One aspect of the disclosed subject matter includes a system for protecting a patient from adverse reaction to a food ingredient, which system is communicatively coupled with a machine.", "The system includes a medical database storing a patient's medical data, and a processor and a memory storing program instructions.", "The program instructions, when executed by the processor, cause the processor to derive a first confidence level data indicating a probability of the patient having adverse reaction to the food ingredient from the patient's medical data.", "In some embodiments, the patient's medical data includes patient's food sensitivity data.", "In certain embodiments, the program instructions also cause the processor to obtain food ingredient information.", "In some embodiments, the food ingredient information can be obtained from sensor data representing a food item from a sensor device.", "Once the sensor data is obtained, the program instructions also cause the processor to derive food ingredient information comprising a second confidence level data indicating a probability of the food ingredient existing in the food item based on the sensor data.", "Then, the program instructions cause the processor to generate a safety level for the patient to consume the food item based on the first and second confidence level data, and then cause the machine to restrict access of the food item according to the generated safety level.", "In some embodiments, the program further causes the processor to perform a step of deriving first confidence level data from data derived from the testing of the patient for a disease using a food preparation having a reference value.", "In certain embodiments, the reference value comprises an average discriminatory p-value of equal or less than 0.15 for a group of individuals not diagnosed with or suspected of having the disease.", "In other embodiments, the program further causes the processor to perform a step of deriving first confidence level data from patient group data of individuals diagnosed of same disease with patient.", "In certain embodiments, the reference value comprises an average discriminatory p-value of equal or less than 0.15 for a group of individuals not diagnosed with or suspected of having the disease.", "In certain embodiments, the reference value in the patient group data is either disease-state stratified or gender stratified to provide more accurate and customized information.", "Further, the patient group data can include experience data of the individuals diagnosed of same disease.", "In addition to the medical data, the program can further causes the processor to derive the first and/or second confidence levels from the patient's experience history and/or group data including others' experience history or sensitivity ratings associated with the food preparations.", "In one embodiment, the group data can be updated and self-learned.", "In this embodiment, the program can further cause the processor to identify a pattern of the group data (e.g., data of the patient group and/or data of the group of individuals not diagnosed of the disease, etc.)", "correlate the pattern with a probability of the patient having adverse reaction to the food ingredient or with a probability of the food ingredient existing in the food item.", "Then, the first confidence level and/or the second confidence level can be automatically updated based on patterns of the group data.", "The sensor data can be spectral analysis data, chemosensing data, or any other suitable type of data that can provide information regarding the food ingredients.", "Based on those sensor data, the program can causes the processor to derive the second confidence level by 1) identifying a food ingredient that is likely to exist in the food item and 2) assigning a probability of the food ingredient.", "In certain embodiments, the program can cause the processor to set a standard to determine the safety level based on the first and second confidence levels.", "In some embodiments, safety level is determined high when the processor determines at least one of the first and second confidence levels is high.", "In other embodiments, safety level is determined high the processor determines both of the first and second confidence levels are low.", "In some embodiments, the machine coupled with the system can be a vending machine, and the program can cause the processor to cause the vending machine fail to vend the food item when the processor determines the safety level low.", "In other embodiments, the machine can be a self check-out kiosk, and the program further causes the processor to cause the self check-out kiosk fail to check out the food items when the processor determines the safety level low.", "Still in other embodiments, the machine is a self-order machine, and the program further causes the processor to cause the self-order machine fail to processes the order of the food items when the processor determines the safety level low.", "Another aspect of the disclosed subject matter includes a system for protecting a patient from adverse reaction to a food ingredient, which system is communicatively coupled with a machine.", "The system includes a medical database storing a patient's medical data, and a processor and a memory storing program instructions.", "The program instructions, when executed by the processor, cause the processor to derive a first confidence level data indicating a probability of the patient having adverse reaction to the food ingredient from the patient's medical data.", "In some embodiments, the patient's medical data includes patient's food sensitivity data.", "The program instructions also cause the processor to obtain food ingredient information.", "In some embodiments, the food ingredient information can be obtained from sensor data representing a food item from a sensor device).", "Once the sensor data is obtained, the program instructions also cause the processor to derive food ingredient information comprising a second confidence level data indicating a probability of the food ingredient existing in the food item based on the sensor data.", "Then, the program instructions cause the processor to generate a safety level for the patient to consume the food item based on the first and second confidence level data, and then cause the a machine to display a food recommendation according to the generated safety level.", "In some embodiments, the recommendation can include alternative food items to the food item if the second confidence value is higher than the first confidence value.", "In these embodiments, that the program may further causes the processor to cause the machine to display a promotional material with the alternative food items.", "Another aspect of the disclosed subject matter includes a method for protecting a patient from adverse reaction to a food ingredient.", "The method begins with a step of deriving a first confidence level data indicating a probability of the patient having adverse reaction to the food ingredient from the patient's medical data.", "Then, the method continues by obtaining food ingredient information.", "In some embodiments, the food ingredient information can be obtained from sensor data representing a food item from a sensor device.", "Once the sensor data is obtained, food ingredient information comprising a second confidence level data can be derived from the sensor data.", "The food ingredient information indicates a probability of the food ingredient existing in the food item.", "Then, based on the first and second confidence level data, a safety level for the patient to consume the food item can be generated.", "Based on the safety level, a machine can restrict a user from an access of the food item.", "Still another aspect of the disclosed subject matter includes a method for protecting a patient from adverse reaction to a food ingredient.", "The method begins with a step of deriving a first confidence level data indicating a probability of the patient having adverse reaction to the food ingredient from the patient's medical data.", "Then, the method continues by obtaining food ingredient information.", "In some embodiments, the food ingredient information can be obtained from sensor data representing a food item from a sensor device.", "Once the sensor data is obtained, food ingredient information comprising a second confidence level data can be derived from the sensor data.", "The food ingredient information indicates a probability of the food ingredient existing in the food item.", "Then, based on the first and second confidence level data, a safety level for the patient to consume the food item can be generated.", "Based on the safety level, a machine can display a food recommendation.", "Still another aspect of the disclosed subject matter includes a computer-readable non-transitory storage medium comprising programming instructions.", "Then programming instructions cause the one or more processors to perform steps of operations when executed by one or more processors.", "The program instructions cause the processor to derive a first confidence level data indicating a probability of the patient having adverse reaction to the food ingredient from the patient's medical data.", "In some embodiments, the patient's medical data includes patient's food sensitivity data.", "The program instructions also cause the processor to obtaining food ingredient information.", "In some embodiments, the food ingredient information can be obtained from sensor data representing a food item from a sensor device.", "Once the sensor data is obtained, the program instructions also cause the processor to derive food ingredient information comprising a second confidence level data indicating a probability of the food ingredient existing in the food item based on the sensor data.", "Then, the program instructions cause the processor to generate a safety level for the patient to consume the food item based on the first and second confidence level data, and then cause the machine to restrict access of the food item according to the generated safety level.", "Still another aspect of the disclosed subject matter includes a computer-readable non-transitory storage medium comprising programming instructions.", "Then programming instructions cause the one or more processors to perform steps of operations when executed by one or more processors.", "The program instructions cause the processor to derive a first confidence level data indicating a probability of the patient having adverse reaction to the food ingredient from the patient's medical data.", "In some embodiments, the patient's medical data includes patient's food sensitivity data.", "The program instructions also cause the processor to obtaining food ingredient information.", "In some embodiments, the food ingredient information can be obtained from sensor data representing a food item from a sensor device.", "Once the sensor data is obtained, the program instructions also cause the processor to derive food ingredient information comprising a second confidence level data indicating a probability of the food ingredient existing in the food item based on the sensor data.", "Then, the program instructions cause the processor to generate a safety level for the patient to consume the food item based on the first and second confidence level data, and then cause the machine to display recommendations according to the generated safety level.", "Various objects, features, aspects and advantages of the disclosed subject matter will become more apparent from the following detailed description of embodiments, along with the accompanying drawing figures in which like numerals represent like components." ], [ "This application is a continuation of International Patent Application No.", "PCT/US2016/043,688, filed Jul.", "22, 2016, which claims priority to U.S. provisional patent application No.", "62/195,663, filed Jul.", "22, 2015, which are incorporated by reference herein in their entirety.", "FIELD The present disclosure relates to methods and systems for providing food and dietary recommendations, and methods and systems for accessing food items based on an individual's sensitivity to specific food or foods.", "BACKGROUND The following description includes information that may be useful in understanding the present disclosure.", "It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.", "Food sensitivities may result in the display of many different types of symptoms and sicknesses associated with one or more food groups or ingredients.", "These symptoms or adverse reactions may arise for a wide variety of reasons, making them complex and oftentimes difficult to treat.", "The cause-effect relationship between food triggers and the resulting symptoms/adverse reactions is not well known, and has not been extensively studied in the medical community.", "Moreover, meaningful diagnostic methods for determining food sensitivities with respect to some food types have not been well established.", "With the diagnostics tests that are available, the quality of the test results is generally poor.", "Typically, problems associated with these tests—as well as the labs interpreting the test results—include high false positive rates, high intra-patient variability, and inter-laboratory variability.", "Accurately identifying the various food ingredients present in food items presents another problem.", "Ambiguous and inconsistent naming conventions amongst food ingredients, and between different food items, can present confusion to the consumer.", "For example, if a patient does not know with any degree of certainty that a specific food item contains an ingredient that is a trigger for food sensitivity, detection of the ingredients from a food label becomes moot.", "Similarly, if the food product description on the packaging is ambiguous (e.g., “crab product” versus ‘soft shell crab’, ‘crab imitation meat’, ‘lobster’, etc.", "), false positive and false negative alerts to the patient may be generated.", "All publications herein are incorporated by reference to the same extent as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference.", "Where a definition or use of a term in an incorporated reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein applies and the definition of that term in the reference does not apply.", "Thus, there is still a need for improved systems and methods for providing food recommendations or improved food access systems and methods based on a patient's food sensitivity testing and available product information.", "SUMMARY The subject matter described herein provides systems, methods, and computer-readable non-transitory storage medium for protecting a patient from adverse reaction to a food ingredient.", "One aspect of the disclosed subject matter includes a system for protecting a patient from adverse reaction to a food ingredient, which system is communicatively coupled with a machine.", "The system includes a medical database storing a patient's medical data, and a processor and a memory storing program instructions.", "The program instructions, when executed by the processor, cause the processor to derive a first confidence level data indicating a probability of the patient having adverse reaction to the food ingredient from the patient's medical data.", "In some embodiments, the patient's medical data includes patient's food sensitivity data.", "In certain embodiments, the program instructions also cause the processor to obtain food ingredient information.", "In some embodiments, the food ingredient information can be obtained from sensor data representing a food item from a sensor device.", "Once the sensor data is obtained, the program instructions also cause the processor to derive food ingredient information comprising a second confidence level data indicating a probability of the food ingredient existing in the food item based on the sensor data.", "Then, the program instructions cause the processor to generate a safety level for the patient to consume the food item based on the first and second confidence level data, and then cause the machine to restrict access of the food item according to the generated safety level.", "In some embodiments, the program further causes the processor to perform a step of deriving first confidence level data from data derived from the testing of the patient for a disease using a food preparation having a reference value.", "In certain embodiments, the reference value comprises an average discriminatory p-value of equal or less than 0.15 for a group of individuals not diagnosed with or suspected of having the disease.", "In other embodiments, the program further causes the processor to perform a step of deriving first confidence level data from patient group data of individuals diagnosed of same disease with patient.", "In certain embodiments, the reference value comprises an average discriminatory p-value of equal or less than 0.15 for a group of individuals not diagnosed with or suspected of having the disease.", "In certain embodiments, the reference value in the patient group data is either disease-state stratified or gender stratified to provide more accurate and customized information.", "Further, the patient group data can include experience data of the individuals diagnosed of same disease.", "In addition to the medical data, the program can further causes the processor to derive the first and/or second confidence levels from the patient's experience history and/or group data including others' experience history or sensitivity ratings associated with the food preparations.", "In one embodiment, the group data can be updated and self-learned.", "In this embodiment, the program can further cause the processor to identify a pattern of the group data (e.g., data of the patient group and/or data of the group of individuals not diagnosed of the disease, etc.)", "correlate the pattern with a probability of the patient having adverse reaction to the food ingredient or with a probability of the food ingredient existing in the food item.", "Then, the first confidence level and/or the second confidence level can be automatically updated based on patterns of the group data.", "The sensor data can be spectral analysis data, chemosensing data, or any other suitable type of data that can provide information regarding the food ingredients.", "Based on those sensor data, the program can causes the processor to derive the second confidence level by 1) identifying a food ingredient that is likely to exist in the food item and 2) assigning a probability of the food ingredient.", "In certain embodiments, the program can cause the processor to set a standard to determine the safety level based on the first and second confidence levels.", "In some embodiments, safety level is determined high when the processor determines at least one of the first and second confidence levels is high.", "In other embodiments, safety level is determined high the processor determines both of the first and second confidence levels are low.", "In some embodiments, the machine coupled with the system can be a vending machine, and the program can cause the processor to cause the vending machine fail to vend the food item when the processor determines the safety level low.", "In other embodiments, the machine can be a self check-out kiosk, and the program further causes the processor to cause the self check-out kiosk fail to check out the food items when the processor determines the safety level low.", "Still in other embodiments, the machine is a self-order machine, and the program further causes the processor to cause the self-order machine fail to processes the order of the food items when the processor determines the safety level low.", "Another aspect of the disclosed subject matter includes a system for protecting a patient from adverse reaction to a food ingredient, which system is communicatively coupled with a machine.", "The system includes a medical database storing a patient's medical data, and a processor and a memory storing program instructions.", "The program instructions, when executed by the processor, cause the processor to derive a first confidence level data indicating a probability of the patient having adverse reaction to the food ingredient from the patient's medical data.", "In some embodiments, the patient's medical data includes patient's food sensitivity data.", "The program instructions also cause the processor to obtain food ingredient information.", "In some embodiments, the food ingredient information can be obtained from sensor data representing a food item from a sensor device).", "Once the sensor data is obtained, the program instructions also cause the processor to derive food ingredient information comprising a second confidence level data indicating a probability of the food ingredient existing in the food item based on the sensor data.", "Then, the program instructions cause the processor to generate a safety level for the patient to consume the food item based on the first and second confidence level data, and then cause the a machine to display a food recommendation according to the generated safety level.", "In some embodiments, the recommendation can include alternative food items to the food item if the second confidence value is higher than the first confidence value.", "In these embodiments, that the program may further causes the processor to cause the machine to display a promotional material with the alternative food items.", "Another aspect of the disclosed subject matter includes a method for protecting a patient from adverse reaction to a food ingredient.", "The method begins with a step of deriving a first confidence level data indicating a probability of the patient having adverse reaction to the food ingredient from the patient's medical data.", "Then, the method continues by obtaining food ingredient information.", "In some embodiments, the food ingredient information can be obtained from sensor data representing a food item from a sensor device.", "Once the sensor data is obtained, food ingredient information comprising a second confidence level data can be derived from the sensor data.", "The food ingredient information indicates a probability of the food ingredient existing in the food item.", "Then, based on the first and second confidence level data, a safety level for the patient to consume the food item can be generated.", "Based on the safety level, a machine can restrict a user from an access of the food item.", "Still another aspect of the disclosed subject matter includes a method for protecting a patient from adverse reaction to a food ingredient.", "The method begins with a step of deriving a first confidence level data indicating a probability of the patient having adverse reaction to the food ingredient from the patient's medical data.", "Then, the method continues by obtaining food ingredient information.", "In some embodiments, the food ingredient information can be obtained from sensor data representing a food item from a sensor device.", "Once the sensor data is obtained, food ingredient information comprising a second confidence level data can be derived from the sensor data.", "The food ingredient information indicates a probability of the food ingredient existing in the food item.", "Then, based on the first and second confidence level data, a safety level for the patient to consume the food item can be generated.", "Based on the safety level, a machine can display a food recommendation.", "Still another aspect of the disclosed subject matter includes a computer-readable non-transitory storage medium comprising programming instructions.", "Then programming instructions cause the one or more processors to perform steps of operations when executed by one or more processors.", "The program instructions cause the processor to derive a first confidence level data indicating a probability of the patient having adverse reaction to the food ingredient from the patient's medical data.", "In some embodiments, the patient's medical data includes patient's food sensitivity data.", "The program instructions also cause the processor to obtaining food ingredient information.", "In some embodiments, the food ingredient information can be obtained from sensor data representing a food item from a sensor device.", "Once the sensor data is obtained, the program instructions also cause the processor to derive food ingredient information comprising a second confidence level data indicating a probability of the food ingredient existing in the food item based on the sensor data.", "Then, the program instructions cause the processor to generate a safety level for the patient to consume the food item based on the first and second confidence level data, and then cause the machine to restrict access of the food item according to the generated safety level.", "Still another aspect of the disclosed subject matter includes a computer-readable non-transitory storage medium comprising programming instructions.", "Then programming instructions cause the one or more processors to perform steps of operations when executed by one or more processors.", "The program instructions cause the processor to derive a first confidence level data indicating a probability of the patient having adverse reaction to the food ingredient from the patient's medical data.", "In some embodiments, the patient's medical data includes patient's food sensitivity data.", "The program instructions also cause the processor to obtaining food ingredient information.", "In some embodiments, the food ingredient information can be obtained from sensor data representing a food item from a sensor device.", "Once the sensor data is obtained, the program instructions also cause the processor to derive food ingredient information comprising a second confidence level data indicating a probability of the food ingredient existing in the food item based on the sensor data.", "Then, the program instructions cause the processor to generate a safety level for the patient to consume the food item based on the first and second confidence level data, and then cause the machine to display recommendations according to the generated safety level.", "Various objects, features, aspects and advantages of the disclosed subject matter will become more apparent from the following detailed description of embodiments, along with the accompanying drawing figures in which like numerals represent like components.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates one embodiment of food access control environment.", "FIG.", "2 illustrates an exemplary embodiment of the food access control environment in the shopping environment.", "FIG.", "3 illustrates a flowchart for one embodiment of methods for protecting patient from adverse reaction to a food ingredient.", "DETAILED DESCRIPTION The disclosed subject matter provides systems, methods, and computer-readable non-transitory storage medium for protecting a patient from adverse reaction to a food ingredient based on the patient's medical data and food ingredient information derived from sensor data of food items and causing a machine to restrict a user from accessing to the food item or displaying a notification of food recommendation in the user device.", "Throughout the following discussion, numerous references will be made regarding servers, services, interfaces, engines, modules, clients, peers, portals, platforms, or other systems formed from computing devices.", "It should be appreciated that the use of such terms is deemed to represent one or more computing devices having at least one processor (e.g., ASIC, FPGA, DSP, x86, ARM, ColdFire, GPU, multi-core processors, etc.)", "configured to execute software instructions stored on a computer readable tangible, non-transitory medium (e.g., hard drive, solid state drive, RAM, flash, ROM, etc.).", "For example, a server can include one or more computers operating as a web server, database server, or other type of computer server in a manner to fulfill described roles, responsibilities, or functions.", "One should further appreciate the disclosed computer-based algorithms, processes, methods, or other types of instruction sets can be embodied as a computer program product comprising a non-transitory, tangible computer readable media storing the instructions that cause a processor to execute the disclosed steps.", "The various servers, systems, databases, or interfaces can exchange data using standardized protocols or algorithms, possibly based on HTTP, HTTPS, AES, public-private key exchanges, web service APIs, known financial transaction protocols, or other electronic information exchanging methods.", "Data exchanges can be conducted over a packet-switched network, a circuit-switched network, the Internet, LAN, WAN, VPN, or other type of network.", "The terms “configured to” and “programmed to” in the context of a processor refer to being programmed by a set of software instructions to perform a function or set of functions.", "While many commercially-packaged food items display nutritional information on their packaging, such as the presence of fats, carbohydrate content, calories, and other ingredients, it is often impossible to find a complete listing of all ingredients or the particular details of a specific ingredient.", "A significant problem includes the presence of “sub-ingredients” that fall within a taxonomic category listed on the food packaging, but having the express identification of those sub-ingredients absent or otherwise hidden within the listed food items.", "For example, even if the food packaging displays information that the food item contains corn syrup as one of main ingredients, such information does not provide details such as whether the corn syrup contains specific types of wheat or whether it does not contain wheat.", "Similarly, some lecithin food additives contain or are derived from egg, while others do not.", "This lack of information is even more pronounced with precooked ready-to-eat food items, or already-prepared meals served in the restaurants, food stands, food trucks, etc.", "Consequently, individuals diagnosed with one or more food sensitivities against various types of food ingredients are often unable to make an informed and appropriate decision as to whether or not a particular dish or food item is suitable for his or her consumption.", "Thus, one should appreciate that the disclosed food recommendation system and method provides numerous advantageous technical effects.", "For example, the food recommendation system and method of some embodiments enables up-to-date food sensitivity and/or food ingredient information by continuously learning different users' food sensitivity and food ingredients in different dishes by pulling (i.e., group-sourcing) real-time information from all users.", "Moreover, by matching or correlating confidence levels of patient test results with confidence levels for ingredient identification, the number of false positive and false negative results can be dramatically reduced.", "In addition, this disclosure allow for construction or configuration of a computing system or device to operate on vast quantities of digital data, beyond the capabilities of a human.", "The computing system or device is able to manage the digital data in a manner that could provide utility to a user of the computing system or device that the user would lack without such a tool.", "One aspect of the disclosed subject matter relates to methods, devices, and systems for controlling food access.", "FIG.", "1 illustrates one embodiment of the food access control environment 100.In some embodiments, the food access control environment 100 includes at least one user device 102a, associated with a user 101a (e.g., patient diagnosed with a condition associated with a food sensitivity, a patient suspected to have a condition with a food sensitivity, etc.).", "In some embodiments, the food access control environment 100 also includes a group of individuals 101b, 101c, 101d (e.g., individuals diagnosed with a condition associated with a food sensitivity, individuals suspected to have a condition with a food sensitivity, individuals without a condition associated with a food sensitivity, etc.).", "In one embodiment, at least one user device 102b, 102c, 102d is associated with each individual 101b, 101c, 101d.", "However, it is contemplated that every individual need not be associated with a user device In FIG.", "1, the user devices 102a, 102b, 102c, 102d are illustrated as smart phones, but user devices may more generally be, for example, another type of digital devices, such as a cell phone, a smart watch, a tablet, a digital organizer, a game console, a computer, a digital camera, an appliance, a kiosk, or a biometric device, which has a memory to store data and programming instructions, and at least one processor for executing the programming instructions.", "In one embodiment, the user devices 102a, 102b, 102c, 102d comprise one or more sensor devices obtaining variable modalities of data.", "For example, the user device 102a, 102b, 102c, 102d can include optical sensors (e.g., a camera, an infrared detector, a spectrometer, etc.", "), chemical sensors (e.g., an electronic nose, a type of MEMS vacuum pump, etc.", "), or other types of sensors that are suitable to detect sound, texture, or other data modalities.", "In some embodiments, the user devices 102a, 102b, 102c, 102d can further include one or more location sensors (e.g., a WiFi signal strength meter, a GPS sensor, an accelerometer, etc.", "), which can be used to detect the location of the devices 106 or 107.As discussed further below, these sensors may provide a form of data modality (e.g., location data, etc.)", "that is useful in obtaining food ingredient information of a food item.", "The food access control environment 100 includes a food access control system 105, which is coupled with the user devices 102a, 102b, 102c, 102d via a device interface 110.In some embodiments, the food access control system 105 is implemented on one or more computing devices having a memory that stores programming instructions, that when executed by the processor(s) of the one or more computing devices, causes the processor(s) to perform functions of the food access control system 105.As shown, in addition to the device interface 110, the food access control system 105 includes a central manager module 115, a data processing module 120, a food sensitivity processing module 125, a food ingredient processing module 130, a safety level processing module 130, an output interface 145 and a database interface 140.As used herein, and unless the context dictates otherwise, the term “coupled to” is intended to include both direct coupling (in which two elements that are coupled to each other contact each other) and indirect coupling (in which at least one additional element is located between the two elements).", "Therefore, the terms “coupled to” and “coupled with” are used synonymously.", "It should be appreciated that the structure of food access control system 105 described in FIG.", "1 is illustrative, and that the structure of food access control system 105 may have a variety of different configurations.", "The modules shown in FIG.", "1 may be reordered or even combined.", "For example, in some embodiments, the functions of the data processing module 120 and the functions of the food sensitivity processing module 125 may be combined, wherein functions of the food sensitivity processing module 125 are leveraged to assist in data processing.", "Accordingly, unless stated otherwise, any reference to a “module” should only be construed as being indicative of the function being performed by that module, and not necessarily a requirement that the particular module being referenced is separate and/or physically distinct from another module, or not coupled to another module.", "The food access control environment 100 also includes a food sensitivity database 150 and a food ingredient database 155, each of which is coupled with the food access control system 105 via the database interface 140.The food sensitivity database 150 stores any data related to the food sensitivity of the patient (e.g., user 101a), including an actual food sensitivity on a food ingredient and/or a suspected food sensitivity on a food ingredient.", "The food sensitivity database 150 also stores any data related to the food sensitivity of one or more of the group of individuals (e.g., individuals 101b, 101c, and 101d) including their actual food sensitivities on one or more food ingredient and/or suspected food sensitivities on one or more food ingredient.", "For example, using the mobile device of a user, the user can report any sensitivity reaction to a food item (e.g., a dish the user consumed at a restaurant, a snack the user consumed, etc.)", "by sending information about the food item (e.g., an image of the food item, describe the food item, a name of the dish and the restaurant from which the user consumed the dish, etc.", "), and also information about the user's adverse symptoms to the food item (e.g., a type of allergic reaction, rashes, etc.).", "The food sensitivity data can be collected from the user, and also other individuals who use the food access control system 105.The process of collecting individuals' food sensitivity data based on the individuals' ongoing experience will be described in more detail below.", "In some embodiments, the food sensitivity database 150 stores medical data of the user 101a (e.g., a patient, etc.)", "and/or one or more individuals 101b, 101c, 101d that are directly received from any healthcare provider (e.g., a hospital, a doctor's office, a dentist's office, a pharmacy, a lab, a doctor, a nurse, a pharmacist, an insurance provider, any point of contact for patient's healthcare, etc.).", "Generally, a patient's medical data generated in the doctor's office is directly transmitted to the medical database 150 with patient's consent to release the data to the database.", "In some embodiments, the medical database is located in a cloud server communicable with healthcare provider's and/or the patient's device via a network.", "In some embodiments, patient's medical data can be transmitted automatically when a health care provider places the information in his or her system (e.g., healthcare provider's computer, etc).", "In other embodiments, a healthcare provider can manually upload the patient's medical data in the medical database.", "It is also contemplated that a patient can upload his or her medical data manually to the database or the food recommendation system application.", "The medical data includes any types of health-related information of the patient.", "For example, the medical data includes any previous personal medical history (e.g., any diagnosis received from any medical provider, etc.", "), any family disease history (e.g., diabetes, heart diseases, neuronal diseases, immune deficiency diseases, etc.", "), and any types of body check-up data (e.g., patient's blood pressure data, heart rate data, body fat data, etc.).", "Thus, as used herein, patient's medical data can be any data on the patient's physical or mental response associated with dietary items (e.g., food items, nutritional items, etc.)", "that negatively impact the patient's health.", "In certain embodiments, the medical data includes the patient's food sensitivity test data.", "Food sensitivity test data can be obtained by any method of evaluating food sensitivity.", "An exemplary method of evaluating food sensitivity is described in International Patent Application Publication No.", "WO 2016/077808, which is incorporated herein by reference in its entirety.", "In another embodiment, the medical data includes a doctor's opinion or recommendation upon the patient's health condition (e.g., restricting the diet to avoid high cholesterol-containing food upon patient's high-risk cardiac condition, etc.).", "In some embodiments, the food sensitivity test data can be derived from the sensitivity testing of a patient diagnosed with, or suspected of having, as disease, illness, or allergy associated with some food items or food ingredients (e.g., Irritable Bowel Syndrome, etc.)", "using a test kit (e.g., multi-well test plate).", "The food sensitivity test can be performed by contacting at least one food preparation (e.g., food item or food ingredient, etc.)", "with a bodily fluid (e.g., blood or saliva, etc.)", "of a patient that is diagnosed with or suspected of having a disease, allergy, or illness (unless stated differently, the term “disease” generally include any disease state, allergy, or illness).", "The bodily fluid contacts the food preparation in a condition that allows for one or more antibodies in the bodily fluid to bind to at least one component of the food preparation.", "Then, the amount of antibody bound to at least one component of the food preparation is measured (e.g., using immuno assay, etc) to obtain a signal.", "Then, the signal is compared to a reference value for the food preparation to provide a report on the patient's sensitivity for the at least one food preparation.", "In some embodiments, the reference value for the food preparation will comprise an average discriminatory p-value of <0.15 for a patient group not diagnosed with or suspected of having the disease.", "In some embodiments, the p-value is <0.10, <0.08, <0.07, <0.06, <0.05, or even <0.025.In some embodiments, the p-value is an average discriminatory p-value determined by raw p-value, or FDR (False Discovery Rate) multiplicity adjusted p-value.", "In some embodiments, the antibody is selected from IgG, IgE, IgA, and/or IgM.", "In some embodiments, the reference value is gender stratified, meaning that p-values are determined separately based on male-only/female-only patient groups not diagnosed with or suspected of having the same disease.", "In some embodiments, the gender-stratified reference value for the food preparation is based on results falling within the 90th percentile value of the patient group.", "In some embodiments, the gender-stratified reference value for the food preparation is based on results falling within the 95th percentile value of the patient group.", "Diagnostic testing kits suitable for obtaining food sensitivity data include those marketed under the name InFoods® by Biomerica Inc. of Irvine, Calif.", "Accordingly, in some embodiments, a patient's food sensitivity data comprises data derived from the testing of the patient for a disease using a food preparation having a reference value, wherein the reference value comprises an average discriminatory p-value of ≤0.15 for a patient group not diagnosed with or suspected of having the disease, allergy, or illness.", "In some embodiments, the food sensitivity data comprises data derived from a gender-stratified p-value.", "In other embodiments, the food sensitivity data comprises data derived from a disease-state -stratified p-value.", "In some embodiments, the medical data includes a doctor's opinion or recommendation upon the patient's health condition (e.g., restricting the diet to avoid high cholesterol-containing food upon patient's high-risk cardiac condition, etc.).", "In some embodiments, the medical data received from health care providers are stored in subdirectories of the medical database 150.For example, any family disease history data can be stored in the family disease history database, the patient's blood pressure data can be stored in the blood pressure database, and the food sensitivity testing data can be stored in the food sensitivity testing database.", "In addition to patient's medical data, the food sensitivity database 150 can also store medical data of one or more individuals 101b, 101c, 101d.", "The medical data of one or more individuals 101b, 101c, 101d includes food sensitivity test data 151a of each of one or more individuals 101b, 101c, 101d.", "The medical data 151a of one or more individuals 101b, 101c, 101d can also include any data related to the past and present health condition 151b (e.g., disease, genetic condition, family history, nutritional information, etc.)", "of the individuals 101b, 101c, 101d.", "Generally, it is contemplated that those data related to the past and present health condition as well as food sensitivity test data 151a of each individual 101b, 101c, 101d are considered sharable information.", "Thus, in some embodiments, the food sensitivity database 150 is a group-sourced database.", "As used herein, group-sourcing refers to the ability of multiple persons to contribute to content.", "With respect to content of a group database as described by this disclosure, there may be a limited number of persons that are allowed to contribute to the content for the database or a specific subdirectories of the database (e.g., food ingredient database, food sensitivity database, etc.).", "However, unless otherwise stated, it should be understood reference to a “group database” or “medical database” could generally refer to data sourced on the same network.", "For example, a group database could be subdirectory in food sensitivity database 150, or a medical database could be a subdirectory in food sensitivity database 150.In addition to individual's medical data, the food sensitivity database 150 can also store experience data 151c of the user 101a and/or one or more group of individuals 101b, 101c, 101d.", "The experience history can be directly or indirectly provided by the user 101a and/or one or more individuals 101b, 101c, 101d via the user devices 102a, 102b, 102c, 102d.", "For example, the user 101a or individuals 101b, 101c, 101d can enter information that they are diagnosed with IBS or suspected to have IBS, and they have experienced adverse symptoms when they consumed manila clams.", "For other example, the user 101a or individuals 101b, 101c, 101d can enter information that while they have not diagnosed with IBS, whenever they consumed tiger shrimp, they experienced similar symptoms with IBS.", "Medical data 151a, 151b or experience data 151c provided by the user 101a and/or one or more individuals 101b, 101c, 101d via the user devices 102a, 102b, 102c, 102d can be received via device interface 110, which is communicatively coupled with the central manager module 115.The central manager module is also communicatively coupled with the data processing module 120.The medical data or experience data are processed (e.g., classified, sorted out, etc.)", "in the data processing module 120 are stored in the food sensitivity database 150 via a database interface 140.The central manager module 115 of the food access control system 105 receives patients and/or other individuals' medical data 151a, 151b or experience data 151c from the food sensitivity database 150.Then, the food sensitivity processing module 125 can derive a first confidence level from the medical data received, based on one or more of a patient's diagnosis, medical recommendations or parameters provided by medical provider, a patient's experience history regarding particular food items, or the experience histories of other users.", "In certain embodiments, the first confidence level data comprises the patient's food sensitivity confidence level data from the patient's and/or other individuals' medical data 151a, 151b or experience data 151c.", "In one embodiment, the patient's food sensitivity confidence level data includes one or more confidence levels (or values) based on one or more food items or ingredients.", "The food sensitivity confidence level data represents a “possibility” or “probability” of a patient to exhibit a symptom (e.g., a symptom associated with an impending reaction, etc.)", "or an adverse reaction (e.g., allergic reactions, etc.)", "related to the food sensitivity when the patient consumes, or is otherwise exposed to (e.g., inhaling, touching, etc.)", "the food item or food ingredient.", "Unless stated to the contrary, as used herein, the term “food item” may comprise one or more food ingredients, while the term “food ingredient” generally refers to a single nutritional component (e.g., soybean oil, etc.)", "of a food item (e.g., soy sauce-flavored instant ramen, etc.).", "In some embodiments, the user 101a and/or a group of individuals 101b, 101c, 101d can continually update his or her experiences with particular food items to the food access control system 105 using the user devices 102a, 102b, 102c, 102d.", "For example, the user 101a can provide an experience “had a headache when I tried the past food item D in restaurant E”.", "The patient can also add the subjective strength of the symptom (e.g., most strong, strong, moderate, weak, etc), which can be objectively converted into a sensitivity confidence value with respect to the particular food items or ingredients.", "This “experience history” can be stored locally in a temporary storage (e.g., memory, etc.)", "in the food access control system 105, and/or uploaded to (and updated on) either the food sensitivity database 150 or food ingredient database 155.Based, at least in part, on the experience history of the user 101a with a particular food item, the food access control system 105 can determine a sensitivity confidence value for the patient on the food item.", "For example, if the patient experienced “very strong ” symptom after consuming the food item D, then the food access control system 105 is programmed to determine that the patient is highly sensitive to food item D and assign an appropriate probability value (e.g., >90%).", "For another example, if the patient experienced moderate symptoms each time the patient consumed food item D, then the food access control system 105 is programmed to determine that the patient is more than likely sensitive to menu D (e.g., sensitivity confidence probability of >50%).", "Furthermore, the food access control system 105 of some embodiments is programmed to make different determinations based on repetition of occurrences of these adverse symptoms.", "For example, if the patient experienced adverse symptoms after consuming food item D only half of the time, the food access control system 105 is programmed to reduce the sensitivity confidence value with respect to that food item D for the patient.", "On the other hand, if the patient experienced adverse symptoms after consuming food item D every time, the food access control system 105 is programmed to increase the sensitivity confidence value with respect to that food item D for the patient.", "Additionally, food access control system 105 can determine the association between the food sensitivity confidence level data and food ingredient confidence level data of the food item D. For example, if the patient's food sensitivity confidence level data (e.g., previously determined and stored in the food sensitivity database 150) indicates that the patient is highly sensitive to only two types of shellfish, and the patient experienced very strong symptom after consuming the food item D, then food access control system 105 is programmed to determine and update the food ingredient confidence level data of the food item D that the food ingredient confidence level of two types of shellfish in food item D is between 70%-100%.", "Accordingly, in some embodiments, the food sensitivity data and/or the food information comprises experience history data of the patient or patients.", "In some embodiments, the food access control system 105 is programmed to receive food sensitivity data from others (e.g., other patients having food sensitivities, etc.)", "and generate the food sensitivity confidence level data of the user 101a at least partly based on the experience histories of other individuals.", "In these embodiments, the food sensitivity database 150 and food ingredient database 155 are configured to store food sensitivity confidence level data and food ingredient confidence level data of a plurality of individuals having food sensitivities against various types of food items.", "In addition, the databases 150 and 155 are also configured to store other individuals' experience histories on food items and its analysis data (e.g., updated food ingredient confidence level data based on the experience history, etc.).", "For example, based on another patient's experience history on food item F and its analysis that the food item F is likely to contain a specific type of cheddar cheese, and based on the instant patient's high food sensitivity confidence level against the specific type of cheddar cheese, the food access control system 105 can generate a recommendation not to consume food item F to the instant patient.", "It is also contemplated that, in some embodiments, the food access control system 105 can modify or update the food ingredient confidence level based on the number and/or frequency of others' sensitivity ratings.", "For example, when more patients provides their experience history that food item F is likely to contain a specific type of cheddar cheese, then the food ingredient confidence level that food item F is likely to contain a specific type of cheddar cheese would be increased.", "In some embodiments, the experience histories of the patient or other individuals may be used to develop the food sensitivity confidence level data that is disease, sickness, or allergy specific.", "For example, it may be understood that a patient group exhibiting symptoms with one category of a disease or syndrome (e.g., Irritable Bowel Syndrome-C (with constipation)) may have a different level of sensitivity for some foods when compared to patient group of another category (e.g., Irritable Bowel Syndrome-D (with diarrhea)).", "Accordingly, in some embodiments, the food sensitivity confidence level data may be disease stratified, wherein unique first confidence level data is assigned for each category of a disease, syndrome, sickness, or allergy.", "In some embodiments, the sensor of the user's device can be used to collect ambient data (e.g., location data, temperature data, time data, etc.)", "in addition to food data.", "In these embodiments, the food access control system 105 is also programmed to use the collected ambient data to derive the food sensitivity value for the patient.", "For example, restaurants might source their food ingredient locally, and the patient may be more sensitive to food ingredient from a certain region than others.", "Furthermore, the patient may also be more sensitive to a certain food ingredient at a certain hour of the day (e.g., more sensitive to caffeine in the morning, etc.).", "Thus, the food access control system 105 of some embodiments is programmed to use the ambient data (e.g., location data, time data, etc.)", "to assist in deriving the food sensitive data for the patient.", "In some embodiments, the food sensitivity confidence level data can be shown in a range of 0-100%.", "Thus, for example, when the patient is highly allergic to pork and is certain to exhibit an adverse reaction (or at least a symptom of an impending reaction) when the patient consumes pork, the food sensitivity confidence level of the patient against pork would be 100%.", "In another example, when the patient has a most likely positive chance of having a symptom when the patient consumes pork, the food sensitivity confidence level of the patient against pork can be ranged at 90-99%.", "In still another example, when the patient more likely than not would have a chance of having a symptom when the patient consumes pork, the food sensitivity confidence level of the patient against pork can be ranged at 50-90%.", "When the patient has only a possibility, or a low probability, of having a symptom or reaction when the patient consumes pork, the food sensitivity confidence level of the patient against pork can be ranged at 10-49%.", "When the patient has essentially no possibility of having a symptom when the patient consumes pork, the food sensitivity confidence level of the patient against pork can be 0%.", "In other embodiments, instead of providing a raw value of food sensitivity confidence level, it is also contemplated that the food sensitivity confidence level data for ingredients can be represented as a high-mid-low possibility level of sensitivity.", "For example, if the food sensitivity confidence level is higher than a high threshold level (e.g., 75%, 80%, 85%, 90%, etc.", "), then the food sensitivity confidence level data for the ingredient can be represented “high”.", "In this example, if the food sensitivity confidence level is higher than a low threshold (e.g., 50%, 45%, 40%, 35%, etc.)", "but lower than the high threshold, then the food sensitivity confidence level data for the ingredient can be represented “mid”.", "Also, if the food sensitivity confidence level is lower than the low threshold, then the food sensitivity confidence level data for the ingredient can be represented “low”.", "The high and low threshold can be determined depending on the severity of general symptoms against the specific food ingredient or the individual's biographical information (e.g., age, gender, ethnicity, medical history, etc.).", "In some other embodiments, the food sensitivity confidence level data is visually displayed to the user 101a.", "For example, the food sensitivity confidence level data can be shown as a graphical continuous progress bar.", "The progress bar can be accompanied with different color representation of bars depending on the level of sensitivity (e.g., red for high level of sensitivity, yellow for mid-level of sensitivity, green for low-level sensitivity, etc.).", "Unless the context dictates the contrary, ranges set forth herein should be interpreted as being inclusive of their endpoints and open-ended ranges should be interpreted to include only commercially practical values.", "The recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each separate value falling within the range.", "Unless otherwise indicated herein, each individual value within a range is incorporated into the specification as if it were individually recited herein.", "Similarly, all lists of values should be considered as inclusive of intermediate values unless the context indicates the contrary.", "The food access control system 105 is also coupled with a food ingredient database 155.The food ingredient database 155 includes food ingredient data comprising any types of information related to the food ingredients of many different food items.", "For example, the food ingredient data can include pre-existing data that has been compiled with respect to the ingredients that make up food items such as ingredient and nutritional information of pre-packed, factory-manufactured food items 156a that are provided by the manufacturer.", "In another example, the food ingredient data can include a product identifier that is a representation (e.g., digital representation) of a food item or an object (e.g., bar code, smart code, etc.)", "associated with the food item.", "In some embodiments, the food ingredient database 155 can include ingredient information of the food items (e.g., home-cooked meals, restaurant foods, etc.)", "that is obtained or received from the user 101a.", "The food ingredient database 155 can also include ingredient information of the food items (e.g., home-cooked meals, restaurant foods, etc.)", "that is obtained or received from the user 101a and/or the group of individuals 101b, 101c, 101d.", "In some embodiments, the digital representation of the food item may already be pre-loaded on the food access control system 105, making it accessible for selection at a later time by the patient, user, or any group of individuals through a scrolling function on device interface 110.These digital representations may be input into the food access control system 105 at any time by the user or any individual maintaining the system.", "For example, the user 101a may independently upload a digital representation acquired from a third party into the food access control system 105 through device interface 110.In another example, the user 101a may directly add food ingredient information to the food access control system 105 through device interface 110 and store it in the food ingredient database 155, and the food access control system 105 can obtain the food ingredient information if necessary.", "It is contemplated that a copy of at least one of food sensitivity database 150 and food ingredient database 155 can be stored in one of the user devices 102a, 102b, 102c, 102d.", "In this embodiment, it is preferred that the food access control system 105 is also executed in that one user device.", "It is also preferred that the copy of the food sensitivity database 150 and/or food ingredient database 155 stored at the user device is synchronized with other copies of food sensitivity database 150 and/or food ingredient database 155 periodically (e.g., every hour, every day, etc.).", "It is also contemplated that at least one of food sensitivity data base 150 and food ingredient database 155 can be located in a third party's computer and be accessible by the user device via a network.", "In some embodiments, one or more of the user devices 102a, 102b, 102c, 102d can receive or obtain sensor data, such as a digital representation of an object associated with a food item 103.The sensor data may comprise one or more of data modalities (e.g., image data, time data, text data, ambient data, etc.", "), which can be used as a product identifier.", "In one embodiment, the object can be a food menu (either in text format or in combination of a graphic and a text formats), a photograph of a food item itself (e.g., a cooked dish, a chunk of meat, mixed vegetables, a bottle of juice, a glass of wine, etc.", "), a photograph of a food packaging or any types of identifiers that can be associated with or represent the food item (e.g., a bar code, a smart code, a food symbol, etc.).", "For example, the object can be a mark, a logo, or a symbol including those found on food packaging or found at restaurant (e.g., restaurant's trademark, trade dress, menus, information charts, etc.).", "In other embodiments, the object can be comprises physical or chemical attributes associated with the food item (e.g., spectral data, chemosensing data, etc.).", "Once the digital representation (e.g., image data, spectral data, chemosensing data) of the object is obtained or received, the food ingredient processing module 130 of the food access control system 105 can extract/derive food information based on the digital representation.", "The food information can include food ingredient information, food nutritional information, or cooking method information.", "For example, from image data of a chop salad from a franchise restaurant A, the food ingredient processing module 130 may detect various ingredients based on shapes, colors, and textures of food ingredients that can be included in the chop salad.", "For another example, from the same image data of the chop salad from a franchise restaurant A, the food ingredient processing module 130 may obtain the cooking recipe of the chop salad and/or nutritional information (e.g., calories, fat content, etc.)", "from the franchise restaurant.", "In some embodiments, food information can be uploaded to and stored in the food ingredient database 155.In other embodiments, food information can be stored in a third party's database.", "The image data of an object associated with a food item can be extracted by food ingredient processing module 130 according to methods known to those skilled in the art.", "In some embodiments, food ingredient processing module 130 is adapted to carry out optical character recognition (OCR) of the digital representation to extract image data associated with any codes, text, shapes, or symbols contained therein.", "In some embodiments, food ingredient processing module 130 may comprise other functionalities such as edge detection, cropping, color balancing, contrast enhancement, spatial filters, noise reduction filters, image analysis algorithms, framegrabbing, or deskewing, which can all be used to provide image data that can provide food information about the food item.", "Applicant has surprisingly discovered, in some embodiments, that food information can be effectively and accurately determined from an object without the need to utilize template-based matching of the image data, or other methods of redundancy analyses to match the image data with pre-loaded templates saved on the system.", "In some embodiments, the user can leverage the ease of capturing a bar code, smart code, or other symbols, which can be used by the system to accurately identify the food item and match it with the food ingredients associated with the food item/bar code stored in the system.", "In some embodiments, the digital representation may provide a level of image data that is not complete enough for the recommendation engine to determine the appropriate level of food information.", "For example, in some embodiments, the image data may comprise extracted data regarding the shape and color of a fruit or vegetable, but the food access control system 105 still cannot correlate the image data with food ingredient data stored on the food ingredient database 155.Accordingly, in some embodiments, the food access control system 105 may prompt the user 101a or the group of individuals 101b, 101c, 101d to provide a positive identification of the food item by making the appropriate selection via device interface 110 from truncated list of fruits and vegetables.", "Once selected, the food ingredient processing module 130 will be able to make the appropriate correlation with food ingredient data stored in the food ingredient database 155.In some embodiments, receiving food information about the food item may comprise any number of known or emerging technologies capable of helping to provide pertinent food ingredient data.", "For example, in some embodiments receiving food information about the food item may comprise spectral analysis or chemosensing of the food item.", "In some embodiments, spectral analysis of the food item may comprise exposing the food item to electromagnetic radiation, and detecting incoming electromagnetic radiation emitted by the food item.", "This may be accomplished by a device designed specifically to determine the food ingredient contents of a food item by exposing it to some forms of radiation, such as a laser or spectrum-narrowed LED.", "Exemplary spectral devices include, but are not limited to, those described in U.S. Pat.", "No.", "9,212,996, which is incorporated herein by reference in its entirety.", "In some embodiments, the target food item will absorb some wavelengths of light depending on its composition, and emit unabsorbed light back to the device.", "In some embodiments, the device will further comprise a grating and/or spectrograph capable of separating the incoming electromagnetic radiation into a frequency spectrum.", "This process may be aided by the use of a lens, which can help diffract and separate the incoming radiation.", "The frequency spectrum may then be emitted into a detector, which is then capable of producing an electrical or electronic signal, which, under the control of controller integrated circuit, can be digitized and transmitted in packets over the network or bus connection by network microcontroller.", "In some embodiments, the digitized spectrum then undergoes processing on a network subsystem(s), which is capable of analyzing the data and providing food information through a ranking process based on the data received.", "Thus, in some embodiments, the method comprises converting the electromagnetic radiation emitted from the food item into digital food component data, and correlating the digital food component data with food ingredient data using a data processing module.", "Like other embodiments described herein, the food ingredient data can be preexisting and stored on the network for accessing when needed.", "In this particular embodiment, the food ingredient data can comprise previously-compiled spectral data for particular food ingredients, which can be matched or correlated with electromagnetic data obtained from the target food item.", "In some embodiments, the spectral device can be integrated into a mobile device or tablet capable of processing the data through a software engine housed on the device, and/or by connection to a network with access to the relevant software engines and databases.", "In some embodiments, chemosensing of the food item comprises exposing the food item to a chemosensor device, and detecting an incoming chemical signal emitted by the food item.", "In some embodiments, chemosensing may comprise an “electronic nose” or “machine olfaction” or “artificial olfactometry,” in which volatile (e.g., gaseous) chemical signatures of a target food item are detected and analyzed for composition.", "In some embodiments, the method comprises converting a detected chemical signal from a food item into digital food component data, and correlating the digital food component data with food ingredient data using a data processing module.", "In some embodiments, the food ingredient data can be preexisting and stored on the network for accessing when needed.", "In this particular embodiment, the food ingredient data can comprise previously-compiled chemical signatures for particular food ingredients, which can be matched or correlated with chemical signal data obtained from the target food item.", "In some embodiments, the chemosensor device can be integrated into a mobile device or tablet capable of processing the data through a software engine housed on the device, and/or by connection to a network with access to the relevant software engines and databases.", "As mentioned above, the sensor of the user's device can be used to collect ambient data (e.g., location data, temperature data, time data, etc.)", "in addition to food data.", "In these embodiments, food ingredient processing module 130 is also programmed to use the collected ambient data to derive the food ingredient value for a food item.", "For example, restaurants might source their food ingredient locally, and the same dish even from the same restaurant chain but from different restaurant locations can include slightly different food ingredients.", "Additionally, temperature might cause some food item to undergo chemical reaction to produce different ingredients than the ones exist when the food item is fresh.", "Thus, the food ingredient processing module 130 of some embodiments is programmed to use the ambient data (e.g., location data, temperature data, time data, etc.)", "to assist in deriving the food ingredient value for a food item.", "In another embodiment, the food ingredient information can be represented second confidence level data.", "In certain embodiments, the second confidence level data comprises food ingredient confidence level data.", "Food ingredient confidence level data represents a possibility or probability that the food item of the sensor data contains a specific ingredient(s).", "Thus, the food ingredient confidence level is derived by identifying a food ingredient, and then assigning the possibility or probability that is likely to exist in the food item.", "In some embodiments, the at least one ingredient confidence value may be independently calculated or compiled by input from physicians and patients through their experience history.", "For example, a patient that only has a known sensitivity to gluten that exhibited a very mild adverse reaction to eating a Brand X cookies could upload that experience to the food ingredient database 155, which may provide the basis for an assigned ingredient confidence value in food ingredient database 155 reflecting a 50% probability that Brand X cookies contain gluten.", "Similarly, a physician examining the ingredients of Brand Y sushi could note the presence of “imitation grab meat” in the ingredient listing, which may provide the basis for an assigned ingredient confidence value in the food ingredient database 155 reflecting a 10% probability or less that Brand Y sushi actually contains real crabmeat.", "In yet another embodiment, detailed information regarding the confidence value of ingredients in some food items can be obtained from the manufacturer or provider of the food item, and made available to the food recommendation system to directly receive food information with an accurate ingredient confidence value.", "For example, in some embodiments, a restaurant can provide food item and food ingredient data associated with some menus in the food ingredient database 155, which may be updated periodically to maintain accuracy.", "In this manner, the second confidence level can be maintained at an extremely accurate level, whereby “educated guesses” based on any incomplete or inaccurate image data does not need to be relied upon by the engine.", "In some embodiments, the user 101a, the group of individuals 101b, 101c, 101d, or any other third party can manually input the identity of the food item and/or food ingredients into the food access control system 105 by using the device interface 110.This food ingredient group data can then be utilized by the food ingredient processing module 130 by correlating it to confidence level data about the food item and/or its ingredients stored on the food ingredient database 155.In another embodiment, as discussed above, the identity of the food item and/or its ingredients can be determined by food ingredient processing module 130 and any image data it extracts from a digital representation of on object associated with the food item, which can similarly be correlated to pertinent information related to the relevant food ingredients of the food item and any confidence level data associated therewith.", "The food ingredient confidence level data can be shown in a range of 0-100%, which represents the “possibility” or “probability” that the food item contains a specific food ingredient.", "For example, when the food packaging displays that the food item contains pork, then the food ingredient confidence level can be 100%.", "Yet, when the chop salad contains a plurality of pieces of ham, and the chance that the ham is a pork ham rather than a turkey ham is 60:40, then food ingredient confidence level of pork can be 60%.", "For another example, if the menu of a restaurant B represents that the menu C is a vegan menu, then the food ingredient confidence level of pork can be closed to 0%.", "In other embodiments, instead of providing a raw value of food sensitivity confidence level, it is also contemplated that the food sensitivity confidence level data for ingredients can be represented as a high-mid-low possibility level of containing specific ingredient.", "For example, if the food ingredient confidence level is higher than a high threshold level (e.g., 75%, 80%, 85%, 90%, etc.", "), then the food ingredient confidence level data for the food item can be represented high.", "In this example, if the food ingredient confidence level is higher than a low threshold (e.g., 50%, 45%, 40%, 35%, etc.)", "but lower than the high threshold, then the food sensitivity confidence level data for the food item can be represented mid.", "Also, if the food ingredient confidence level is lower than the low threshold, then the food ingredient confidence level data for the food item can be represented low.", "The high and low threshold can be determined depending on many variables (e.g., cooking methods, amount of the ingredient expected to be in the food item, etc.).", "In some other embodiments, the food ingredient confidence level data is visually displayed to the user 101a or other users.", "For example, the food ingredient confidence level data can be shown as a graphical continuous progress bar.", "The progress bar can be accompanied with different color representation of bars depending on the level of sensitivity (e.g., red for high level of possibility, yellow for mid-level of possibility, etc.).", "Unless otherwise stated, it should be understood that the elements of the methods described herein can generally occur in any particular order that still allows for the generation of a reliable food recommendation.", "Thus, for example, in some embodiments it may not be necessary to receive food sensitivity data before receiving food information about a food item.", "In fact, in some embodiments, it may be desirable to first receive food information about a food item in order to determine the confidence level of some food ingredients being present in a food item.", "In this embodiment, the system could then receive any food sensitivity data of the patient as it specifically relates to those relevant food ingredients, without having to access data related to any and all food ingredient sensitivities generally associated with the patient.", "In one embodiment, the food access control system 105 can perform machine learning with respect to determining the food sensitivity confidence level.", "The food sensitivity test data and/or experience data of the user 101a, or a group of individuals 101b, 101c, 101d.", "In this embodiment, the food access control system 105 can identify a pattern of food sensitivity data or food ingredient data by the user 101a and/or a group of individuals 101b, 101c, 101d.", "For example, when the food access control system 105 receives increasing number of food sensitivity data from the suspected IBS patients group that more patients have had adverse reaction to the Alaska king crab caught last winter season.", "Then, the food access control system 105 can identify the pattern that suspected IBS patients group now have increased sensitivity to the Alaska king crab caught last winter season.", "Once the pattern is identified, then the food access control system 105 can correlate the pattern with a probability or possibility of the patient to have an adverse reaction to the specific food ingredient.", "For example, from the pattern that suspected IBS patients group now have increased sensitivity to the Alaska king crab caught last winter season, the food access control system 105 can correlate that IBS patients or a person who has similar symptoms with IBS patients has a higher probability or possibility to have an adverse reaction to the Alaska king crab caught last winter season.", "Then, the food access control system 105 can automatically update the food sensitivity confidence level for the user (the patient 101a) that the food sensitivity confidence level for the Alaska king crab caught last winter season increases.", "Similarly, the food access control system 105 can perform machine learning with respect to determining the food ingredient confidence level.", "In this embodiment, when the food access control system 105 receives more data from a group of people with high sensitivity to tiger shrimps that many of them had an adverse reaction to the fishcake soup in Restaurant A.", "Then, the food access control system 105 automatically updates the food ingredient confidence level for the fishcake soup in Restaurant A.", "Once the food sensitivity confidence level data and food ingredient confidence level data is generated, the safety level processing module 135 is configured to compare the food sensitivity confidence level data and food ingredient confidence level data and generate a safety level for the user 101a to consume the food item.", "In some embodiments, the safety level is calculated by considering the food sensitivity confidence level and the food ingredient confidence level equally.", "However, it is also contemplated that the safety level is calculated by weighing the food sensitivity confidence level more than the food ingredient confidence level or vice versa.", "In some embodiments, the safety level can be represented in a range of 0-100%.", "For example, when it is determined that absolutely safe for the user 101a to consume a food item 103(e.g., the patient has no food sensitivity to all food ingredients in the food item 103 or the food item 103 has no possibility to include any food ingredients that the patient may have adverse reaction to, etc.", "), then the safety level can be 100%.", "In contrast, when it is determined that absolutely dangerous for the user 101a to consume a food item 103 (e.g., the patient has severe food sensitivity to at least one or more food ingredients in the food item 103 or the food item 103 has 100% possibility to include any food ingredients that the patient may have adverse reaction to, etc.", "), then the safety level can be 0%.", "For another example, if the food sensitivity confidence level data is lower than food ingredient confidence level data, and the food sensitivity confidence level data is higher than 50%, then a safety level of less than 40% can be generated.", "For another example, if the food sensitivity confidence level data is higher than food ingredient confidence level data and the food sensitivity confidence level data is close to 100%, then a the safety level of over 90% can also be generated.", "Yet, if the food sensitivity confidence level data is higher than food ingredient confidence level data, and the food sensitivity confidence level data is close to 50%, then a safety level of 50% can be generated.", "If the food sensitivity confidence level data and food ingredient confidence level data are both lower than 50%, then safety level of lower than 25% can be generated.", "In other embodiments, instead of providing a raw value of safety level, it is also contemplated that the safety level data for the user 101a to consume the food item 103 can be represented as a high-mid-low possibility level.", "For example, if the safety level is higher than a high threshold level (e.g., 75%, 80%, 85%, 90%, etc.", "), then the safety level data for the food item can be represented high.", "In this example, if the safety level is higher than a low threshold (e.g., 50%, 45%, 40%, 35%, etc.)", "but lower than the high threshold, then safety level data for the food item can be represented mid.", "Also, if the safety level is lower than the low threshold, then the safety level data for the food item can be represented low.", "The high and low threshold can be determined depending on many variables that are considered to determine the food sensitivity confidence level and food ingredient confidence level.", "In some other embodiments, the safety level data is visually displayed to the user 101a or other users.", "For example, the safety level data can be shown as a graphical continuous progress bar.", "The progress bar can be accompanied with different color representation of bars (e.g., red for low safety level, yellow for safety level, green for high safety level, etc.).", "Once the safety level data is generated by the safety level processing module 135, the safety level processing module 135 can also generate recommendation on the food item based on the safety level.", "The recommendation generated in the safety level processing module 135 can be displayed in a display device 165 via the output interface 145.In certain embodiments, display device 165 is user device 102a.", "The safety level processing module 135 is configured to create or cause the display device 165 to create text data, sound data, or graphic data corresponding to each notification type (e.g., “High Warning”, “Moderate Warning”, or “No Warning”).", "In some embodiments, the notification is displayed with at least one of text data, sound data, or graphic data.", "In other embodiments, the notification can be displayed with a combination of two or more types of data (e.g., text warning with an alarm sound, a text warning with a graphic warning sign, a graphic warning sign with an alarm sound, etc.).", "In other embodiments, the safety level processing module 135 is configured to create the ranking among multiple recommendations (e.g., high warning goes first and no warning goes last, etc.", "), and is also configured to create the notification based on the ranking.", "The safety level processing module 135 can also generate recommendations of alternative food items that may be of a similar food category, but have no warning or a low warning if a High or Moderate warning is displayed with the original food item target.", "In some embodiments, alternative food item(s) can be displayed with the original food item warning notification, or as a separate link associated with the warning notification.", "In some embodiments, the alternative food item can be displayed with the lowest ranking as an alternative to the high or moderate ranking.", "In certain embodiments, the user 101a is associated with the display device 165.However, it is also contemplated that the recommendation can be displayed in the display device 165 is not directly associated with the patient (e.g., a caregiver's device, a cook's device, etc.).", "In some embodiments, the food recommendation or alternative food recommendation may be associated with promotional material.", "The promotional material may comprise sponsored, third-party advertisements for foods and/or services associated with the food recommendation.", "In some embodiments, the promotional material comprises at least one of a brand advertisement, a product rebate, a product coupon, or a product instant savings notice (e.g., $1.00 off credited at supermarket checkout, etc.).", "In some embodiments, the food sensitivity confidence level can comprise any significance level of dietary ingredient to the patient's health condition.", "Thus, in some embodiments, the food access control system 105 is configured to receive diagnosis results or recommendations from medical providers to generate food recommendations to the user (e.g., patients 101a, etc).", "For example, the patient's medical data in the food sensitivity database 150 may comprise a doctor's recommendation to restrict high-cholesterol containing foods for improving or maintaining the patient's cardiac condition.", "Then, the food access control system 105 can compare the food ingredient confidence level of food items (e.g., cholesterol types or amounts in the food items) and provide recommendation to the user 101a or other users (e.g., caregivers, etc.).", "In some embodiments, the food access control system 105 is further configured to obtain medical data associated with a plurality of persons (e.g., family of four persons, etc.)", "to provide a plurality of recommendations or to provide a best suitable recommendation meeting all persons' food sensitivity confidence level data.", "For example, a family of four persons can have multiple health conditions or food sensitivities.", "The food recommendation engine 110 is configured to obtain all medical data of the family members, and can provide multiple recommendations at the same time (e.g., avoid menu A, C, and D in restaurant F), or the best suitable recommendation for the entire family (e.g., the best menu that you can all share is menu G in restaurant F).", "The food access control system 105 can also modulate the operation of a machine 160 that is communicatively coupled with the food access control system 105 according to the safety level data generated in the safety level processing module 135.In some embodiments, the machine can be at least one of the user devices 102a, 102b, 102c, 102d.", "In other embodiments, the machine can be different devices other than the user devices 102a, 102b, 102c, 102d, which can be communicatively coupled to the at least one or more user devices 102a, 102b, 102c, 102d.", "For example, the machine 160 can be a vending machine with various food items.", "The food access control system 105 can configure the vending machine not to vend a food item that has low safety level to a person who attempts to use the vending machine to purchase the food item.", "For another example, the machine 160 can be a self-order kiosk for food items.", "The food access control system 105 can configure the self-order kiosk not to display the food ingredient (e.g., mustard sauce for a hamburger, etc.)", "from the menu list, or prevent from checking out the order if the ordered food item contains food ingredient with low safety level.", "One of the self-order kiosks includes an online shopping or online order system (e.g., webpage, a mobile application, etc.)", "that displays warning signs or refuses to check out the user's orders when the user attempts to place, or places a food item with low safety level in the shopping cart of the online order system.", "In this scenario, the computer can label or mark the order of the food item in the shopping cart in a specific color (e.g., red text or highlighted, etc.", "), or attach a warning sign (“!” mark or “WARNING”, “DANGER”, etc.", "), or even refuse to place the food item in the shopping cart.", "For still another example, the machine is a beverage-making machine (e.g., capsule coffee/tea machine, etc.", "), and the food access control system 105 can configure the beverage-making machine not to brew the beverage and/or providing a warning sign on the LED screen of the machine, if the beverage is likely to contain food ingredient (e.g., caffeine, etc.)", "with low safety level.", "For still another example, the machine is a robot cook that receives an order for dishes from the patients.", "Based on the health condition that requires food restriction as well as safety levels of food items, the food access control system 105 can configure the robot cook to refuse to cook a specific dish, provide verbal or text recommendation to the user 101a for alternative dishes, or cook the ordered dish with or without content of the user 101a using alternative ingredient that has higher safety level for the patient to consume.", "It is contemplated that the machine 160 can also be any computer that provides browsing functions and/or location-detection functions.", "For example, the machine 160 can be a computer, and the food access control system 105 can configure the computer to limit the user access to some specific food items by providing additional filtering in the browser (e.g., not showing specific food items in the on-line ordering system, not showing some recipes using the specific food items).", "For another example, the machine 160 is a computer coupled with a refrigerator or a pantry that the food access control system 105 can configure the computer to automatically cancel the order of a food item for restocking the refrigerator or a pantry if the food item has a low safety level to the user of the refrigerator or the pantry.", "Instead, the food access control system 105 can configure the computer to automatically order a substitute (or recommended alternative) food item when the user of the refrigerator or the pantry attempts to order the food item with a low safety level.", "FIG.", "2 shows one exemplary food access control environment 200.In this food access control environment 200, the food access control system 105 is communicatively coupled with the user 101a, and other individuals 101b, 101c, who are coupled with user devices 102a, 102b, 102c, respectively.", "The user 101a is in the supermarket and considers purchasing a boxed salad 203a for her lunch.", "The user 101a recently diagnosed with a mild IBS and have had adverse reactions (e.g., diarrhea, etc.)", "whenever she had grilled Italian zucchini.", "Her medical information of mild IBS diagnosis is transmitted from her medical data storage at her doctor's office stored in the food sensitivity database 150 after being processed at the food access control system 105.The patient's experience information about grilled Italian zucchini is entered by the patient and also stored in the food sensitivity database 150 after the data is processed at the food access control system 105.Food sensitivity database 150 also stores food sensitivity data of another individual 101b who also have diagnosed with a mild IBS with similar symptoms with the patient 101a.", "The food sensitivity data of another individual 101b indicates that the individual 101b have had adverse reaction to peanut oils.", "Based on the patient's medical data and experience data, as well as other individual's (with the same disease and similar symptoms), the food access control system 105 determines that the food sensitivity confidence level of the Italian zucchini is high (e.g., more than 90%, etc.", "), and the food sensitivity confidence level of the peanut oil is likely high (e.g., more than 70%, etc.).", "When the user 101a is interested in purchasing the boxed salad 203a having a barcode 204a, the patient takes a photograph of the content of the boxed salad 203a and/or scans the barcode on the exterior of the salad box with the camera of the patient's user device 102a.", "The visual representation of the salad content and/or the barcode is transmitted to the food access control system 105, where the food ingredient information is extracted based on the visual representation.", "For example, from the photograph of the content of the boxed salad, the data processing module 120 of the food access control system 105 can extract the information that the boxed salad may contain lettuces, carrots, cheddar cheese, Brussels sprouts, and Italian zucchini based on the shape and color of the content.", "For other example, from scanned barcode 204a, the data processing module 120 of the food access control system 105 can extract the information that the boxed salad 203a that in addition to lettuces, carrots, cheddar cheese, Brussels sprouts, and Italian zucchini, the boxed salad 203a contains crushed walnuts and minced raisins.", "Based on the information, the food access control system 105 can determine the food ingredient confidence level of the boxed salad 203a that the food ingredient confidence level for lettuces, carrots, cheddar cheese, Brussels sprouts, Italian zucchini, crushed walnuts and minced raisins are high (e.g., over 90%, etc.)", "The food ingredient database 155 may also include food ingredient information for the same boxed salad 203b having a barcode 204b that is generated by and transmitted from another individual 101c.", "The individual 101c have not diagnosed with IBS and does not have any symptom of IBS.", "Yet, the individual 101c have had adverse reactions on peanut oil.", "The individual 101c had purchased the same boxed salad 203b having a barcode 204b, and had an adverse reaction over the salad.", "The individual 101c entered food ingredient information that he suspects that the boxed salad 203b may contain peanut oil.", "Based on the individual's 101c experience data, the food access control system 105 can update the food ingredient information of the boxed salad 203b that the food ingredient confidence level that the boxed salad 203b contains peanut oil is moderate to high (e.g., 50-75%, 60-80%, etc.)", "Based on the food sensitivity confidence data and the food ingredient confidence data, the food access control system 105 can determine the safety level for the user 101a to consume the boxed salad 203a.", "Because the food sensitivity confidence level is high for Italian zucchini and moderate-high (likely high) for peanut oil, and the food ingredient confidence level for Italian zucchini and peanut oil is high and moderate-high, the safety level for the user 101a to consume the boxed salad 203a is likely low.", "The food access control system 105 is coupled with a cashier's counter 260, which includes a display 265.Once the food access control system 105 determines that the safety level for the user 101a to consume the boxed salad 203a is low, the food access control system 105 can cause the cashier's counter 260 refuse to check out of the boxed salad 203a when the patients attempts to check out.", "In addition, the food access control system 105 can cause the display 265 associated with the cashier's counter to display a warning sign to the cashier (e.g., “NO PROCESSING ALLOWED”, etc.)", "or a warning sign to the patient (e.g., “DANGEROUS TO CONSUME”, etc.).", "Further, the food access control system 105 can cause display 265 to show the list of alternative food items safer for the user 101a to consume, and cause the cashier's counter 260 to print a promotional material including coupons for the alternative food items.", "In certain embodiments, virtual reality or augmented reality-type programs and devices may be integrated into the systems and methods described herein.", "In certain embodiments the food access control system may provide user 101a with an augmented reality platform at one or more of the stages of methods described herein.", "For example, an augmented reality could be provided to user 101a during the steps of obtaining sensor data and/or generating a safety level.", "The capturing of real-time video, digital representations, and/or other sensor data could be augmented to provide user 101a with virtual options or recommendations.", "In such embodiments, virtual food recommendations or alternatives may be provided to user 101a on device 102a (e.g., smartphone, smartwatch, virtual reality headset, etc.", "), which may selected or scrolled though by the user.", "Another aspect of the disclosed subject matter relates to method for protecting a patient from adverse reaction to a food ingredient.", "FIG.", "3 illustrate a flowchart of one embodiment of the methods.", "The methods begins with a step 305 of obtaining or receiving the user's (e.g., patient's) medical data and/or other individuals' (e.g., individuals having same disease or similar symptoms, etc.)", "medical data.", "In some embodiments, the medical data is directly transmitted from a medical provider or a healthcare provider (e.g., a hospital, a doctor's office, a dentist's office, a pharmacy, a lab, a doctor, a nurse, a pharmacist, an insurance provider, any point of contact for patient's healthcare, etc.)", "under the patient's consent to release the data.", "In one embodiment, the medical data includes food sensitivity test data and/or experience data of one or more individuals.", "Once the medical data is obtained or received, the medical data is stored in the food sensitivity database.", "Then, based on the medical data, the method continues with a step 310 of deriving a food sensitivity confidence level (a first confidence level), which indicates a probability of the user having an adverse reaction to the food ingredient.", "The method continues with a step 315 of obtaining sensor data (e.g., a digital representation) of an object (e.g., a bar code, a photo of a cooked dish, etc), associated with a food item.", "In one embodiment, the image data is acquired by an image acquisition device (e.g., a camera on the mobile device).", "However, it is contemplated that any suitable sensor data to extract food ingredient information can be used.", "Also, it is contemplated that any pre-existing, pre-processed image data (e.g., screen captured image data on the personal computer, etc.)", "can be used.", "Once the sensor data is acquired, the method further continues with a step 320 of deriving food ingredient confidence level (a second confidence level) from the sensor data.", "The food ingredient confidence level indicates a probability or possibility that a food ingredient exists in the food item.", "Then, the method continues with a step 325 of determining a safety level for the patient to consume the food item based on the food sensitivity confidence level and the food ingredient confidence level.", "If the safety level is low (e.g., dangerous for the patient to consume the food item, etc.", "), the method continues with a step 330 of causing a machine to restrict access of the user to the food item.", "The step 330 may also include to display recommendations to the client or the third party not to consume the food item or not to provide the food item to the patient.", "It should be apparent to those skilled in the art that many more modifications besides those already described are possible without departing from the disclosed concepts herein.", "The disclosed subject matter, therefore, is not to be restricted except in the spirit of the appended claims.", "Moreover, in interpreting both the specification and the claims, all terms should be interpreted in the broadest possible manner consistent with the context.", "In particular, the terms “comprises” and “comprising” should be interpreted as referring to elements, components, or steps in a non-exclusive manner, indicating that the referenced elements, components, or steps may be present, or utilized, or combined with other elements, components, or steps that are not expressly referenced.", "Where the specification claims refers to at least one of something selected from the group consisting of A, B, C .", ".", ".", "and N, the text should be interpreted as requiring only one element from the group, not A plus N, or B plus N, etc." ] ]
Patent_15875900
[ [ "APPARATUS FOR TRANSMITTING BROADCAST SIGNALS, APPARATUS FOR RECEIVING BROADCAST SIGNALS, METHOD FOR TRANSMITTING BROADCAST SIGNALS AND METHOD FOR RECEIVING BROADCAST SIGNALS", "A method and apparatus for transmitting broadcast signals are discussed.", "The method can include generating an input stream having plural input packets, link processing the input packets in the input stream to generate link layer packets, physical processing the link layer packets into the broadcast signals, and transmitting the broadcast signals.", "The link processing can include generating a payload of a link layer packet by encapsulating either a segment of one input packet or concatenated input packets, generating a header of the link layer packet including a base part, the base part including a first field which indicates whether the payload includes either the segment or the concatenated input packets, and inserting the header in front of the payload;" ], [ "1.A method of transmitting broadcast signals, the method comprising: generating an input stream having plural input packets; link processing the input packets in the input stream to generate link layer packets, wherein the link processing includes: generating a payload of a link layer packet by encapsulating either a segment of one input packet or concatenated input packets.", "generating a header of the link layer packet including a base part, the base part including a first field which indicates whether the payload includes either the segment or the concatenated input packets, and inserting the header in front of the payload: physical processing the link layer packets into the broadcast signals; and transmitting the broadcast signals, wherein the generating a header further comprises: determining whether to add either a segmentation header part or a concatenation header part to the header based on value of the first field, and adding the concatenation header part after the base part when the payload includes the concatenated input packets, by including a second field that indicates a number of concatenated input packet to the header, and by including third fields to the header in the same order as the concatenated input packets present in the payload.", "wherein a value of the second field is set to the number of concatenated packet—2, wherein the third fields indicating length of each of the concatenated input packets, wherein the number of the third fields is determined based on the number of the concatenated input packets in the payload, and adding stuffing bits after the third fields when the number or the third fields is odd.", "2.The method of claim 1, wherein the base part further includes a fourth field indicating a type of the input packets included in the payload.", "3.An apparatus for transmitting broadcast signals, the apparatus comprising: a processor configured to generate an input stream having plural input packets, wherein the processor is further configured to link process the input packets in the input stream to generate link layer packets, wherein to link process, the processor is further configured to: generate a payload of a link layer packet by encapsulating either a segment of one input packet or concatenated input packets.", "generate a header of the link layer packet including a base part, the base part including a first field which indicates whether the payload includes either the segment or the concatenated input packets, and insert the header in front of the payload.", "wherein the processor is further configured to physical process the link layer packets into the broadcast signals; and a transmitter configured to transmit the broadcast signals, wherein, to generate the header, the processor is further configured to: determine whether to add either a segmentation header part or a concatenation header part to the header based on value of the first field, and add the concatenation header part after the base part when the payload includes the concatenated input packets, by including a second field that indicates a number of concatenated input packet to the header, and by including third fields to the header in the same order as the concatenated input packets present in the payload, wherein a value of the second field is set to the number of concatenated packet—2, wherein the third fields indicating length of each of the concatenated input packets, wherein the number of the third fields is determined based on the number of the concatenated input packets in the payload, and add stuffing bits after the third fields when the number of the third fields is odd.", "4.The apparatus of claim 3, wherein the base part further includes a fourth field indicating type of the input packets included in the payload.", "5.A method of receiving broadcast signals, the method comprising: receiving the broadcast signals; physical processing the broadcast signals into link layer packets; and link processing the link layer packets to restore input stream having plural input packets.", "wherein the link processing includes: extracting a header from a link layer packet, parsing a base part of the header, the base part including a first field which indicates whether a payload of the link layer packet includes either the segment or the concatenated input packets, determining whether the payload of the link layer packet includes either the segment or the concatenated input packets based on the first field, parsing a concatenation header part after the base part when the first field indicates that the payload of the link layer packet includes the concatenated input packets, wherein the concatenation header part includes a second field indicating a number of concatenated input packet, and third fields indicating length of each of the concatenated input packets, wherein a value of the second field is set to the number of concatenated packet-2.wherein the number of the third fields is determined based on the number of the concatenated input packets in the payload, and restoring the output packets, by decapsulating the payload of the link layer packet, and by dividing the concatenated input packets in the same order as the third fields present in the concatenation header part using the second field and the third fields.", "6.The method of claim 5, further comprising: disregarding stuffing bits afier the third fields when the number of the third fields is odd.", "7.The method of claim 5, wherein the base part further includes a fourth field indicating a type of the input packets included in the payload.", "8.An apparatus for receiving broadcast signals, the apparatus comprising: a tuner configured to receive the broadcast signals; a processor configured to physical process the broadcast signals into link layer packets; the processor further configured to link process the link layer packets to restore input stream having plural input packets, wherein, to link process, the processor is further configured to: extract a header from a link layer packet, parse a base part of the header, the base part including a first field which indicates whether a payload of the link layer packet includes either the segment or the concatenated input packets, and determine whether the payload of the link layer packet includes either the segment or the concatenated input packets based on the first field, parse a concatenation header part after the base part when the first field indicates that the payload of the link layer packet includes the concatenated input packets, wherein the concatenation header part includes a second field indicating a number of concatenated input packet, and third fields indicating length of each of the concatenated input packets, wherein a value of the second field is set to the number of concatenated packet—2, wherein the number of the third fields is determined based on the number of the concatenated input packets in the payload, restore the output packets, by decapsulating the payload of the link layer packet, and by dividing the concatenated input packets in the same order as the third fields present in the concatenation header part using the second field and the third fields.", "9.The apparatus of claim 8, wherein, to link process, the processor is further configured to: disregard stuffing bits after the third fields when the number of the third fields is odd.", "10.The apparatus of claim 8, wherein the base part further includes a fourth field indicating a type of the input packets included in the payload." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>An object of the present invention is to provide an apparatus and method for transmitting broadcast signals to multiplex data of a broadcast transmission/reception system providing two or more different broadcast services in a time domain and transmit the multiplexed data through the same RF signal bandwidth and an apparatus and method for receiving broadcast signals corresponding thereto.", "Another object of the present invention is to provide an apparatus for transmitting broadcast signals, an apparatus for receiving broadcast signals and methods for transmitting and receiving broadcast signals to classify data corresponding to services by components, transmit data corresponding to each component as a data pipe, receive and process the data.", "Still another object of the present invention is to provide an apparatus for transmitting broadcast signals, an apparatus for receiving broadcast signals and methods for transmitting and receiving broadcast signals to signal signaling information necessary to provide broadcast signals.", "To achieve the object and other advantages and in accordance with the purpose of the invention, as embodied and broadly described herein, the present invention provides a method of transmitting broadcast signals.", "The method of transmitting broadcast signals includes generating plural input streams, wherein each of the plural input streams include plural input packets; link layer processing the input packets in the plural input streams to generate link layer packets; physical layer processing the link layer packets in physical layer, to generate the broadcast signals; and transmitting the generated broadcast signals.", "Preferably, the link layer processing includes link layer processing one of the plural input streams based on transparent mode, wherein the link layer processing one of the plural input streams based on transparent mode includes: delivering the one of the plural input streams to the physical layer without encapsulating.", "Preferably, the link layer processing includes link layer processing one of the plural input streams based on normal mode, wherein the link layer processing one of the plural input streams based on normal mode includes: encapsulating the input packets in the one of the plural input streams to generate the link layer packets, and delivering the generated link layer packets to the physical layer.", "Preferably, the link layer processing one of the plural input streams based on normal mode further includes: overhead reduction processing the input packets in the one of the plural input streams before encapsulating, by compressing headers of the input packets.", "Preferably, the link layer processing one of the plural input streams based on normal mode further includes: extracting a first signaling information from overhead reduction processed input packets, wherein the first signaling information is a signaling information to be transmitted in a dedicated transmission channel; and delivering the extracted first signaling information to the physical layer.", "Preferably, the link layer processing one of the plural input streams based on normal mode further includes: extracting second signaling information, wherein the second signaling information is for signaling data in the input packets; encapsulating the extracted second signaling information to generate link layer packets: and delivering the generated link layer packets to the physical layer.", "Preferably, the link layer packet includes a link layer payload generated by using a segment of one of the input packets, or by using concatenated input packets.", "Preferably, the physical layer processing includes: physical layer processing plural Plops (Physical Layer Pipes) including data of the link layer packets, to generate the broadcast signals.", "Preferably, the physical layer processing includes: physical layer processing the first signaling information into the dedicated transmission channel, to generate the broadcast signals.", "Preferably, the input packets are one of TS (Transport Stream) packet, IP (Internet Protocol) packet or GS (Generic Stream) packet.", "In other aspect, the present invention provides an apparatus for transmitting broadcast signals.", "The apparatus for transmitting broadcast signals includes a first module that generates plural input streams, wherein each of the plural input streams include plural input packets; a second module that link layer processes the input packets in the plural input streams to generate link layer packets; a third module that physical layer processes the link layer packets, to generate the broadcast signals; and a fourth module that transmits the generated broadcast signals.", "Preferably, the second module link layer processes one of the plural input streams based on transparent mode, wherein the second module delivers the one of the plural input streams to the third module without encapsulating.", "Preferably, the second module link layer processes one of the plural input streams based on normal mode, wherein the second module encapsulates the input packets in the one ot the plural input streams to generate the link layer packets, and wherein the second module delivers the generated link layer packets to the third module.", "Preferably, the second module overhead reduction processes the input packets in the one of the plural input streams before encapsulating, by compressing headers of the input packets.", "Preferably, the second module extracts a first signaling information from overhead reduction processed input packets, wherein the first signaling information is a signaling information to be transmitted in a dedicated transmission channel; and wherein the second module delivers the extracted first signaling information to the third module.", "Preferably, the second module extracts second signaling information, wherein the second signaling information is for signaling data in the input packets; wherein the second module encapsulates the extracted second signaling information to generate link layer packets; and wherein the second module delivers the generated link layer packets to the third module.", "Prferably, the link layer packet includes a link layer payload generated by using a segment of one of the input packets, or by using concatenated input packets.", "Preferably, the third module physical layer processes plural Plops (Physical Layer Pipes) including data of the link layer packets, to generate the broadcast signals.", "Preferably, the third module physical layer processes the first signaling information into the dedicated transmission channel, to generate the broadcast signals.", "Preferably, the input packets are one of TS (Transport Stream) packet, IP (Internet Protocol) packet or GS (Generic Stream) packet.", "The present invention can process data according to service characteristics to control QoS (Quality of Services) for each service or service component, thereby providing various broadcast services.", "The present invention can achieve transmission flexibility by transmitting various broadcast services through the same RF signal bandwidth.", "The present invention can improve data transmission efficiency and increase robustness of transmission/reception of broadcast signals using a MIMO system.", "According to the present invention, it is possible to provide broadcast signal transmission and reception methods and apparatus capable of receiving digital broadcast signals without error even with mobile reception equipment or in an indoor environment." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This Application is a Continuation of co-pending U.S. patent application Ser.", "No.", "14/906,796 filed on Jan. 21, 2016, which is the National Phase of PCT International Application No.", "PCT/KR2015/000367 filed on Jan. 14, 2015, which claims the benefit under 35 U.S.C.", "§ 119(e) to U.S.", "Provisional Application Nos.", "61/927,453, filed on Jan. 14, 2014, 61/926,958 filed on Jan. 14, 2014 and 61/935,863 filed on Feb. 5, 2014, all of which are hereby expressly incorporated by reference into the present application.", "BACKGROUND OF THE INVENTION Field of the Invention The present invention relates to an apparatus for transmitting broadcast signals, an apparatus for receiving broadcast signals and methods for transmitting and receiving broadcast signals.", "Discussion of the Related Art As analog broadcast signal transmission comes to an end, various technologies for transmitting/receiving digital broadcast signals are being developed.", "A digital broadcast signal may include a larger amount of video/audio data than an analog broadcast signal and further include various types of additional data in addition to the video/audio data.", "That is, a digital broadcast system can provide HD (high definition) images, multi-channel audio and various additional services.", "However, data transmission efficiency for transmission of large amounts of data, robustness of transmission/reception networks and network flexibility in consideration of mobile reception equipment need to be improved for digital broadcast.", "SUMMARY OF THE INVENTION An object of the present invention is to provide an apparatus and method for transmitting broadcast signals to multiplex data of a broadcast transmission/reception system providing two or more different broadcast services in a time domain and transmit the multiplexed data through the same RF signal bandwidth and an apparatus and method for receiving broadcast signals corresponding thereto.", "Another object of the present invention is to provide an apparatus for transmitting broadcast signals, an apparatus for receiving broadcast signals and methods for transmitting and receiving broadcast signals to classify data corresponding to services by components, transmit data corresponding to each component as a data pipe, receive and process the data.", "Still another object of the present invention is to provide an apparatus for transmitting broadcast signals, an apparatus for receiving broadcast signals and methods for transmitting and receiving broadcast signals to signal signaling information necessary to provide broadcast signals.", "To achieve the object and other advantages and in accordance with the purpose of the invention, as embodied and broadly described herein, the present invention provides a method of transmitting broadcast signals.", "The method of transmitting broadcast signals includes generating plural input streams, wherein each of the plural input streams include plural input packets; link layer processing the input packets in the plural input streams to generate link layer packets; physical layer processing the link layer packets in physical layer, to generate the broadcast signals; and transmitting the generated broadcast signals.", "Preferably, the link layer processing includes link layer processing one of the plural input streams based on transparent mode, wherein the link layer processing one of the plural input streams based on transparent mode includes: delivering the one of the plural input streams to the physical layer without encapsulating.", "Preferably, the link layer processing includes link layer processing one of the plural input streams based on normal mode, wherein the link layer processing one of the plural input streams based on normal mode includes: encapsulating the input packets in the one of the plural input streams to generate the link layer packets, and delivering the generated link layer packets to the physical layer.", "Preferably, the link layer processing one of the plural input streams based on normal mode further includes: overhead reduction processing the input packets in the one of the plural input streams before encapsulating, by compressing headers of the input packets.", "Preferably, the link layer processing one of the plural input streams based on normal mode further includes: extracting a first signaling information from overhead reduction processed input packets, wherein the first signaling information is a signaling information to be transmitted in a dedicated transmission channel; and delivering the extracted first signaling information to the physical layer.", "Preferably, the link layer processing one of the plural input streams based on normal mode further includes: extracting second signaling information, wherein the second signaling information is for signaling data in the input packets; encapsulating the extracted second signaling information to generate link layer packets: and delivering the generated link layer packets to the physical layer.", "Preferably, the link layer packet includes a link layer payload generated by using a segment of one of the input packets, or by using concatenated input packets.", "Preferably, the physical layer processing includes: physical layer processing plural Plops (Physical Layer Pipes) including data of the link layer packets, to generate the broadcast signals.", "Preferably, the physical layer processing includes: physical layer processing the first signaling information into the dedicated transmission channel, to generate the broadcast signals.", "Preferably, the input packets are one of TS (Transport Stream) packet, IP (Internet Protocol) packet or GS (Generic Stream) packet.", "In other aspect, the present invention provides an apparatus for transmitting broadcast signals.", "The apparatus for transmitting broadcast signals includes a first module that generates plural input streams, wherein each of the plural input streams include plural input packets; a second module that link layer processes the input packets in the plural input streams to generate link layer packets; a third module that physical layer processes the link layer packets, to generate the broadcast signals; and a fourth module that transmits the generated broadcast signals.", "Preferably, the second module link layer processes one of the plural input streams based on transparent mode, wherein the second module delivers the one of the plural input streams to the third module without encapsulating.", "Preferably, the second module link layer processes one of the plural input streams based on normal mode, wherein the second module encapsulates the input packets in the one ot the plural input streams to generate the link layer packets, and wherein the second module delivers the generated link layer packets to the third module.", "Preferably, the second module overhead reduction processes the input packets in the one of the plural input streams before encapsulating, by compressing headers of the input packets.", "Preferably, the second module extracts a first signaling information from overhead reduction processed input packets, wherein the first signaling information is a signaling information to be transmitted in a dedicated transmission channel; and wherein the second module delivers the extracted first signaling information to the third module.", "Preferably, the second module extracts second signaling information, wherein the second signaling information is for signaling data in the input packets; wherein the second module encapsulates the extracted second signaling information to generate link layer packets; and wherein the second module delivers the generated link layer packets to the third module.", "Prferably, the link layer packet includes a link layer payload generated by using a segment of one of the input packets, or by using concatenated input packets.", "Preferably, the third module physical layer processes plural Plops (Physical Layer Pipes) including data of the link layer packets, to generate the broadcast signals.", "Preferably, the third module physical layer processes the first signaling information into the dedicated transmission channel, to generate the broadcast signals.", "Preferably, the input packets are one of TS (Transport Stream) packet, IP (Internet Protocol) packet or GS (Generic Stream) packet.", "The present invention can process data according to service characteristics to control QoS (Quality of Services) for each service or service component, thereby providing various broadcast services.", "The present invention can achieve transmission flexibility by transmitting various broadcast services through the same RF signal bandwidth.", "The present invention can improve data transmission efficiency and increase robustness of transmission/reception of broadcast signals using a MIMO system.", "According to the present invention, it is possible to provide broadcast signal transmission and reception methods and apparatus capable of receiving digital broadcast signals without error even with mobile reception equipment or in an indoor environment.", "BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the principle of the invention.", "In the drawings: FIG.", "1 illustrates a structure of an apparatus for transmitting broadcast signals for future broadcast services according to an embodiment of the present invention.", "FIG.", "2 illustrates an input formatting block according to one embodiment of the present invention.", "FIG.", "3 illustrates an input formatting block according to another embodiment of the present invention.", "FIG.", "4 illustrates an input formatting block according to another embodiment of the present invention.", "FIG.", "5 illustrates a BICM block according to an embodiment of the present invention.", "FIG.", "6 illustrates a BICM block according to another embodiment of the present invention.", "FIG.", "7 illustrates a frame building block according to one embodiment of the present invention.", "FIG.", "8 illustrates an OFDM generation block according to an embodiment of the present invention.", "FIG.", "9 illustrates a structure of an apparatus for receiving broadcast signals for future broadcast services according to an embodiment of the present invention.", "FIG.", "10 illustrates a frame structure according to an embodiment of the present invention.", "FIG.", "11 illustrates a signaling hierarchy structure of the frame according to an embodiment of the present invention.", "FIG.", "12 illustrates preamble signaling data according to an embodiment of the present invention.", "FIG.", "13 illustrates PLS1 data according to an embodiment of the present invention.", "FIG.", "14 illustrates PLS2 data according to an embodiment of the present invention.", "FIG.", "15 illustrates PLS2 data according to another embodiment of the present invention.", "FIG.", "16 illustrates a logical structure of a frame according to an embodiment of the present invention.", "FIG.", "17 illustrates PLS mapping according to an embodiment of the present invention.", "FIG.", "18 illustrates EAC mapping according to an embodiment of the present invention.", "FIG.", "19 illustrates F1C mapping according to an embodiment of the present invention.", "FIG.", "20 illustrates a type of DP according to an embodiment of the present invention.", "FIG.", "21 illustrates DP mapping according to an embodiment of the present invention.", "FIG.", "22 illustrates an FEC structure according in an embodiment of the present invention.", "FIG.", "23 illustrates a bit interleaving according to an embodiment of the present invention.", "FIG.", "24 illustrates a cell-word demultiplexing according to an embodiment of the present invention.", "FIG.", "25 illustrates a time interleaving according to an embodiment of the present invention.", "FIG.", "26 illustrates the basic operation of a twisted row-column block interleaver according to an embodiment of the present invention.", "FIG.", "27 illustrates an operation of a twisted row-column block interleaver according to another embodiment of the present invention.", "FIG.", "28 illustrates a diagonal-wise reading pattern of a twisted row-column block interleaver according to an embodiment of the present invention.", "FIG.", "29 illustrates interleaved XFECBLOCKs from each interleaving array according to an embodiment of the present invention.", "FIG.", "30 is a conceptual diagram illustrating a protocol stack for the next generation broadcast system based on hybrid according to an embodiment of the present invention.", "FIG.", "31 is a conceptual diagram illustrating an interface of a link layer according to an embodiment of the present invention.", "FIG.", "32 is a conceptual diagram illustrating a packet structure of a link elayer according to an embodiment of the present invention.", "FIG.", "33 shows packet types dependent upon the packet type element values according to an embodiment of the present invention.", "FIG.", "34 is a conceptual diagram illustrating a header structure of a link layer packet when an IP packet is transmitted to the link layer according to an embodiment of the present invention.", "FIG.", "35 is a conceptual diagram illustrating the meaning and header structures according to C/S field values.", "FIG.", "36 is a conceptual diagram illustrating the meaning according to the count field values.", "FIG.", "37 is a conceptual diagram illustrating the meaning and segment lengths according to values of Seg_Len_ID field.", "FIG.", "38 is a conceptual diagram illustrating an equation for encapsulating a normal packet and an equation for calculating a link layer packet length.", "FIG.", "39 is a conceptual diagram illustrating a process for encapsulating a concatenated packet and an equation for calculating a link layer packet length.", "FIG.", "40 is a conceptual diagram illustrating a process for calculating the length of a concatenated packet including an IPv4 packet and an equation for calculating an offset value at whieh a length field of the IP packet is located.", "FIG.", "41 is a conceptual diagram illustrating a process for calculating the length of a concatenated packet including an IPv6 packet and an equation for calculating an offset value at which a length field of the IP packet is located.", "FIG.", "42 is a conceptual diagram illustrating an encapsulation process of a segmented packet according to an embodiment of the present invention.", "FIG.", "43 is a concepuial diagram illustrating a segmentation process of an IP packet and header information of a link layer packet according to an embodiment of the present invention.", "FIG.", "44 is a conceptual diagram illustrating a segmentation process of an IP packet including a cyclic redundancy check (CRC) according to an embodiment of the present invention.", "FIG.", "45 is a conceptual diagram illustrating a header structure of a link layer packet when MPEG-2 TS (Transport Stream) is input to a link layer according to an embodiment of the present invention.", "FIG.", "46 shows the number of MPEG-2 TS packets contained in a payload of the link layer packet according to values of a count field.", "FIG.", "47 is a conceptual diagram illustrating a header of the MPEG-2 TS packet according to an embodiment of the present invention.", "FIG.", "48 is a conceptual diagram illustrating a process for allowing a transceiver to change a usage of a transport error indicator field according to an embodiment of the present invention.", "FIG.", "49 is a conceptual diagram illustrating an encapsulation process of the MPEG-2 TS packet according to an embodiment of the present invention.", "FIG.", "50 is a conceptual diagram illustrating an encapsulation process of the MPEG-2 TS packet having the same PID according to an embodiment of the present invention.", "FIG.", "51 is a conceptual diagram illustrating an equation for calculating the length of a link layer packet through a Common PID reduction process and a Common PID reduction process.", "FIG.", "52 is a conceptual diagram illustrating the number of concatenated MPEG-2 TS packets and the length of a link layer packet according to count field values when Common PID reduction is used.", "FIG.", "53 is a conceptual diagram illustrating a process for encapsulating the MPEG-2 TS packet including a null packet according to an embodiment of the present invention.", "FIG.", "54 is a conceptual diagram illustrating a step for processing an indicator configured to count a removed null packet and an equation for calculating the length of a link layer packet in the processing step.", "FIG.", "55 is a conceptual diagram illustrating a process for encapsulating the MPEG-2 TS packet including a null packet according to another embodiment of the present invention.", "FIG.", "56 is a conceptual diagram illustrating a process for encapsulating the MPEG-2 TS packets including the same packet identifiers (PIDs) in a stream including a null packet according to an embodiment of the present invention.", "FIG.", "57 is a conceptual diagram illustrating an equation for calculating the length of a link layer packet when the MPEG-2 TS packets having the same PIDs are encapsulated in a stream including a null packet according to an embodiment of the present invention.", "FIG.", "58 is a conceptual diagram illustrating a link layer packet structure for transmitting signaling information according to an embodiment of the present invention.", "FIG.", "59 is a conceptual diagram illustrating a link layer packet structure for transmitting the framed packet according to an embodiment of the present invention.", "FIG.", "60 shows a syntax of the framed packet according to an embodiment of the present invention.", "FIG.", "61 is a block diagram illustrating a receiver of the next generation broadcast system according to an embodiment of the present invention.", "FIG.", "62 is a conceptual diagram illustrating a general format of a section table according to an embodiment of the present invention.", "FIG.", "63 is a conceptual diagram illustrating a link layer packet for transmitting signaling information according to an embodiment of the present invention.", "FIG.", "64 shows the meaning of values denoted by the signaling type field, and contents of a fixed header and an extended header located behind the signaling type field.", "FIG.", "65 shows the number of descriptors contained in payload of the link layer pocket according to a concatenation count field value according to an embodiment of the present invention.", "FIG.", "66 is a conceptual diagram illustrating a process for encapsulating the section table into payload when signaling information input to the payload of the link layer packet is a section table.", "FIG.", "67 is a conceptual diagram illustrating a syntax of a network information table (NIT) according to an embodiment of the present invention.", "FIG.", "68 is a conceptual diagram illustrating a syntax of a delivery system descriptor contained in a network information table (NIT) according to an embodiment of the present invention.", "FIG.", "69 is a conceptual diagram illustrating a syntax of a fast information table (FTT) according to an embodiment of the present invention.", "FIG.", "70 is a conceptual diagram illustrating a process for encapsulating a descriptor into payload when signaling information input to payload of the link layer packet is a descriptor.", "FIG.", "71 is a conceptual diagram illustrating a syntax of a fast information descriptor according to an embodiment of the present invention.", "FIG.", "72 is a conceptual diagram illustrating a delivery system descriptor according to an embodiment of the present invention.", "FIG.", "73 is a conceptual diagram illustrating a process for encapsulating one GSE-LLC datum into payload of one link layer packet when signaling information input to payload of the link layer packet has a GSE-LLC format used in DVB-GSE.", "FIG.", "74 is a conceptual diagram illustrating a process for encapsulating one GSE-LLC datum into payload of several link layer packets when signaling information input to payload of the link layer packet has a GSE-LLC format used in a DVB-GSE standard.", "FIG.", "75 illustrates a header of a link layer packet for Robust Header Compression (RoHC) transmission according to the present invention.", "FIG.", "76 illustrates Embodiment #1 of a method of transmitting an RoHC packet using a link layer packet, according to the present invention.", "FIG.", "77 illustrates Embodiment #2 of a method of transmitting an RoHC packet using a link layer packet, according to the present invention.", "FIG.", "78 illustrates Embodiment #3 of a method of transmitting an RoHC packet using a link layer packet, according to the present invention.", "FIG.", "79 illustrates Embodiment #4 of a method of transmitting an RoHC packet using a link layer packet, according to the present invention.", "FIG.", "80 illustrates a header of a link layer packet for RoHC transmission according to an embodiment of the present invention when an MTU is 1,500.FIG.", "81 illustrates Embodiment #1 of a method of transmitting an RoHC packet using a link layer packet when an MTU is 1,500 according to the present invention.", "FIG.", "82 illustrates Embodiment #2 of a method of transmitting an RoHC packet using a link layer packet when an MTU is 1,500 according to the present invention.", "FIG.", "83 illustrates Embodiment #3 of a method of transmitting an RoHC packet using a link layer packet when an MTU is 1,500 according to the present invention.", "FIG.", "84 illustrates Embodiment #4 of a method of transmitting an RoHC packet using a link layer packet when an MTU is 1,500 according to the present invention.", "FIG.", "85 illustrates Embodiment #5 of a method of transmitting an RoHC packet using a link layer packet when an MTU is 1,500, according to the present invention.", "FIG.", "86 illustrates Embodiment #6 of a method of transmitting an RoHC packet using a link layer packet when an MTU is 1,500, according to the present invention.", "FIG.", "87 illustrates Embodiment #7 of a method of transmitting an RoHC packet using a link layer packet when an MTU is 1,500, according to the present invention.", "FIG.", "88 illustrates a protocol stack for a hybrid-based next generation broadcast system according to another embodiment of the present invention.", "FIG.", "89 illustrates an operation in a normal mode corresponding to one of operation modes of a link layer according to an embodiment of the present invention.", "FIG.", "90 illustrates an operation in a transparent mode corresponding to one of operation modes of a link layer according to an embodiment of the present invention.", "FIG.", "91 illustrates a configuration of a link layer at a transmitter according to an embodiment of the present invention (normal mode).", "FIG.", "92 illustrates a con figuration of a link layer at a receiver according to an embodiment of the present invention (normal mode).", "FIG.", "93 illustrates a method of transmitting broadcast signals according to an embodiment of the present invention.", "DETAILED DESCRIPTION OF THE EMBODIMENTS Reference will now be made in detail to the preferred embodiments of the present invention, examples of which are illustrated in the accompanying drawings.", "The detailed description, which will be given below with reference to the accompanying drawings, is intended to explain exemplary embodiments of the present invention, rather than to show the only embodiments that can be implemented according to the present invention.", "The following detailed description includes specific details in order to provide a thorough understanding of the present invention.", "However, it will be apparent to those skilled in the art that the present invention may be practiced without such specific details.", "Although most terms used in the present invention have been selected from general ones widely used in the art, some terms have been arbitrarily selected by the applicant and their meanings are explained in detail in the following description as needed.", "Thus, the present invention should be understood based upon the intended meanings of the terms rather than their simple names or meanings.", "The present invention provides apparatuses and methods for transmitting and receiving broadcast signals for future broadcast services.", "Future broadcast services according to an embodiment of the present invention include a terrestrial broadcast service, a mobile broadcast service, a UHDTV service, etc.", "The present invention may process broadcast signals for the future broadcast services through non-MIMO (Multiple Input Multiple Output) or MIMO according to one embodiment.", "A non-MIMO scheme according to an embodiment of the present invention may include a MISO (Multiple Input Single Output) scheme, a SISO (Single Input Single Output) scheme, etc.", "While MISO or MIMO uses two antennas in the following for convenience of description, the present invention is applicable to systems using two or more antennas.", "The present invention may defines three physical layer (PL) profiles (base, handheld and advanced profiles), each optimized to minimize receiver complexity while attaining the performance required for a particular use case.", "The physical layer (PHY) profiles are subsets of all configurations dial a corresponding receiver should implement.", "The three PHY profiles share most of the functional blocks but differ slightly in specific blocks and/or parameters.", "Additional PHY profiles can be defined in the future.", "For the system evolution, future profiles can also be multiplexed with the existing profiles in a single RF channel through a future extension frame (FEF).", "The details of each PHY profile are described below.", "1.Base Profile The base profile represents a main use case for fixed receiving devices that are usually connected to a roof-top antenna.", "The base profile also includes portable devices that could be transported to a place but belong to a relatively stationary reception category.", "Use of the base profile could be extended to handheld devices or even vehicular by some improved implementations, but those use cases are not expected for the base profile receiver operation.", "Target SNR range of reception is from approximately 10 to 20 dB, which includes the 5 dB SNR reception capability of the existing broadcast system (c,g.", "ATSC A/53).", "The receiver complexity and power consumption is not as critical as in the battery-operated handheld devices, which will use the handheld profile.", "Key system parameters for the base profile are listed in below table 1.TABLE 1 LDPC codeword length 16K, 64K bits Constellation size 4~10 bpcu (bits per channel use) Time de-interleaving memory size ≤219 data cells Pilot patterns Pilot pattern for fixed reception FFT size 16K, 32K points 2.Handheld Profile The handheld profile is designed for use in handheld and vehicular devices that operate with battery power.", "The devices can be moving with pedestrian or vehicle speed.", "The power consumption as well as the receiver complexity is very important for the implementation of the devices of the handheld profile.", "The target SNR range of the handheld profile is approximately 0 to 10 dB, but can be configured to reach below 0 dB when intended for deeper indoor reception.", "In addition to low SNR capability, resilience to the Doppler Effect caused by receiver mobility is the most important performance attribute of the handheld profile.", "Key system parameters for the handheld profile are listed in the below table 2.TABLE 2 LDPC codeword length 16K bits Constellation size 2~8 bpcu Time de-interleaving memory size ≤218 data cells Pilot patterns Pilot patterns for mobile and indoor reception FFT size 8K, 16K points 3.Advanced Profile The advanced profile provides highest channel capacity at the cost of more implementation complexity.", "This profile requires using MIMO transmission and reception, and UHDTV service is a target use case for which this profile is specifically designed.", "The increased capacity can also be used to allow an increased number of services in a given bandwidth, e.g., multiple SDTV or HDTV services.", "The target SNR range of the advanced profile is approximately 20 to 30 dB.", "MIMO transmission may initially use existing elliptically-polarized transmission equipment, with extension to full-power cross-polarized transmission in the future.", "Key system parameters for the advanced profile are listed in below table 3.TABLE 3 LDPC codeword length 16K, 64K bits Constellation size 8~12 bpcu Time de-interleaving memory size ≤219 data cells Pilot patterns Pilot pattern for fixed reception FFT size 16K, 32K points In this case, the base profile can be used as a profile for both the terrestrial broadcast service and the mobile broadcast service.", "That is, the base profile can be used to define a concept of a profile which includes the mobile profile.", "Also, the advanced profile can be divided advance profile for a base profile with MIMO and advanced profile for a handheld profile with MIMO.", "Moreover, the three profiles can be changed according to intention of the designer.", "The following terms and definitions may apply to the present invention.", "The following terms and definitions can be changed according to design.", "auxiliary stream: sequence of cells carrying data of as yet undefined modulation and coding, which may be used for future extensions or as required by broadcasters or network operators base data pipe: data pipe that carries service signaling data baseband frame (or BBFRAME): set of Kbch bits which form the input to one FEC encoding process (BCH and LDPC encoding) cell: modulation value that is carried by one carrier of the OFDM transmission coded block: LDPC-encodcd block of PLS1 data or one of the LDPC-encoded blocks of PLS2 data data pipe: logical channel in the physical layer that carries service data or related metadata, which may carry one or multiple service(s) or service component(s).", "data pipe unit: a basic unit for allocating data cells to a DP in a frame, data symbol: OFDM symbol in a frame which is not a preamble symbol (the frame signaling symbol and frame edge symbol is included in the data symbol) DP_ID: this 8-bit field identifies uniquely a DP within the system identified by the SYSTEM_ID dummy cell: cell carrying a pseudo-random value used to fill the remaining capacity not used for PLS signaling, DPs or auxiliary streams emergency alert channel: part of a frame that carries FAS information data frame: physical layer time slot that starts with a preamble and ends with a frame edge symbol frame repetition unit: a set of frames belonging to same or different physical layer profile including a FEF, which is repeated eight times in a super-frame fast information channel: a logical channel in a frame that carries the mapping information between a service and the corresponding base DP FECBLOCK: set of LDPC-encoded bits of a DP data FFT size: nominal FFT size used for a particular mode, equal to the active symbol period Ts expressed in cycles of the elementary period T frame signaling symbol: OFDM symbol with higher pilot density used at the start of a frame in certain combinations of FFT size, guard interval and scattered pilot pattern, which carries a part of the PLS data frame edge symbol: OFDM symbol with higher pilot density used at the end of a frame in certain combinations of FFT size, guard interval and scattered pilot pattern frame-group: the set of all the frames having the same PHY profile type in a super-frame.", "future extension frame: physical layer time slot within the super-frame that could be used for future extension, which starts with a preamble Futurecast UTB system: proposed physical layer broadcasting system, of which the input is one or more MPBG2-TS or IP or general stream(s) and of which the output is an RF signal input stream: A stream of data for an ensemble of services delivered to the end users by the system.", "normal data symbol: data symbol excluding the frame signaling symbol and the frame edge symbol PHY profile: subset of all configurations that a corresponding receiver should implement PLS: physical layer signaling data consisting of PLS1 and PLS2 PLS1: a first set of PLS data carried in the FSS symbols having a fixed size, coding and modulation, which carries basic information about the system as well as the parameters needed to decode the PLS2 NOTE: PLS1 data remains constant for the duration of a frame-group.", "PLS2: a second set of PLS data transmitted in the FSS symbol, which carries more detailed PLS data about the system and the DPs PLS2 dynamic data: PLS2 data that may dynamically change frame-by-frame PLS2 static data: PLS2 data that remains static for the duration of a frame-group preamble signaling data: signaling data carried by the preamble symbol and used to identify the basic mode of the system preamble symbol: fixed-length pilot symbol that carries basic PLS data and is located in the beginning of a frame NOTE: The preamble symbol is mainly used for fast initial band scan to detect the system signal, its timing, frequency offset and FFT-size.", "reserved for future use; not defined by the present document but may be defined in future super-frame: set of eighl frame repetition units time interleaving block (TI block): set of cells within which time interleaving is carried out, corresponding to one use of the time interleaver memory TI group: unit over which dynamic capacity allocation for a particular DP is carried out, made up of an integer, dynamically varying number of XFECBLOCKs.", "NOTE: The TI group may be mapped directly to one frame or may be mapped to multiple frames.", "It may contain one or more TI blocks.", "Type 1 DP: OP of a frame where all DPs are mapped into the frame in TDM fashion Type 2 DP: DP of a frame where all DPs are mapped into the frame in EDM fashion XFECBLOCK: set of Ncells cells carrying all the bits of one LDPC FECBLOCK FIG.", "1 illustrates a structure of an apparatus for transmitting broadcast signals for future broadcast services according to an embodiment of the present invention.", "The apparatus for transmitting broadcast signals for future broadcast services according to an embodiment of the present invention can include an input formatting block 1000, a BICM (Bit interleaved coding & modulation) block 1010, a frame structure block 1020, an OFDM (Orthogonal Frequency Division Multiplexing) generation block 1030 and a signaling generation block 1040.A description will be given of the operation of each module of the apparatus for transmitting broadcast signals.", "IP stream/packets and MPEG2-TS are the main input formats, other stream types are handled as General Streams.", "In addition to these data inputs, Management Information is input to control the scheduling and allocation of the corresponding bandwidth for each input stream.", "One or multiple TS strcam(s), IP stream(s) and/or General Stream's) inputs are simultaneously allowed.", "The input formatting block 1000 can demultiplex each input stream into one or multiple data pipe(s), to each of which an independent coding and modulation is applied.", "The data pipe (DP) is the basic unit for robustness control, thereby affecting quality-of-service (QoS).", "One or multiple servicer(s) or service component(s) can be carried by a single DP.", "Details of operations of the input formatting block 1000 will be described later.", "The data pipe is a logical channel in the physical layer that carries service data or related metadata, which may carry one or multiple servicc(s) or service component(s).", "Also, the data pipe unit: a basic unit for allocating data cells to a DP in a frame.", "In the BICM block 1010, parity data is added for error correction and the encoded bit streams are mapped to complex-value constellation symbols.", "The symbols are interleaved across a specific interleaving depth that is used for the corresponding DP.", "For the advanced profile.", "MIMO encoding is performed in the BICM block 1010 and the additional data path is added at the output for MIMO transmission.", "Details of operations of the BICM block 1010 will be described later.", "The Frame Building block 1020 can map the data cells of the input DPs into the OFDM symbols within a frame.", "After mapping, the frequency interleaving is used for frequency-domain diversity, especially to combat frequency-selective fading channels.", "Details of operations of the Frame Building block 1020 will be described later.", "After inserting a preamble at the beginning of each frame, the OFDM Generation block 1030 can apply conventional OFDM modulation having a cyclic prefix as guard interval.", "For antenna space diversity, a distributed MISO scheme is applied across the transmitters.", "In addition, a Peak-to-Average Power Reduction (PAPK) scheme is performed in the time domain.", "For flexible network planning, this proposal provides a set of various FFT sizes, guard interval lengths and corresponding pilot patterns.", "Details of operations of the OFDM Generation block 1030 will be described later.", "The Signaling Generation block 1040 can create physical layer signaling information used for the operation of each functional block.", "This signaling information is also transmitted so that the services of interest are properly recovered at the receiver side.", "Details of operations of the Signaling Generation block 1040 will be described later.", "FIGS.", "2, 3 and 4 illustrate the input formatting block 1000 according to embodiments of the present invention.", "A description will be given of each figure.", "FIG.", "2 illustrates an input formatting block according to one embodiment of the present invention.", "FIG.", "2 shows an input formatting module when the input signal is a single input stream.", "The input formatting block illustrated in FIG.", "2 corresponds to an embodiment of the input formatting block 1000 described with reference to FIG.", "1.The input to the physical layer may be composed of one or multiple data streams.", "Each data stream is carried by one DP.", "The mode adaptation modules slice the incoming data stream into data fields of the baseband frame (BBF).", "Hie system supports three types of input data streams: MPEG2-TS.", "Internet protocol (IP) and Generic stream (GS).", "MPEG2-TS is characterized by fixed length (188 byte) packets with the first byte being a sync-byte (0x47).", "An IP stream is composed of variable length IP datagram packets, as signaled within IP packet headers.", "The system supports both IPv4 and IPv6 for the IP stream.", "GS may be composed of variable length packets or constant length packets, signaled within encapsulation packet headers.", "(a) shows a mode adaptation block 2000 and a stream adaptation 2010 for signal DP and (b) shows a PLS generation block 2020 and a PLS scrambler 2030 for generating and processing PLS data.", "A description will be given of the operation of each block.", "The Input Stream Splitter splits the input TS, IP, GS streams into multiple service or service component (audio, video, etc.)", "streams.", "The mode adaptation module 2010 is comprised of a CRC Encoder, BB (baseband) Frame Slicer, and BB Frame Header Insertion block.", "The CRC Encoder provides three kinds of CRC encoding for error detection at the user packet (UP) level, i.e., CRC-8, CRC-16, and CRC-32.The computed CRC bytes are appended after the UP.", "CRC-8 is used for TS stream and CRC-32 for IP stream.", "If the GS stream doesn't provide the CRC encoding, the proposed CRC encoding should be applied.", "BB Frame Slicer maps the input into an internal logical-bit format.", "The first received bit is defined to be the MSB.", "The BB Frame Slicer allocates a number of input bits equal to the available data field capacity.", "To allocate a number of input bits equal to the BBF payload, the UP packet stream is sliced to fit the data field of BBF.", "BB Frame Header Insertion block can insert fixed length BBF header of 2 bytes is inserted in front of the BB Frame.", "The BBF header is composed of STUFF) (1 bit).", "SYNCD (13 bits), and RFU (2 bits).", "In addition to the fixed 2-byte BBF header, BBF can have an extension field (1 or 3 bytes) at the end of the 2-byte BBF header.", "The stream adaptation 2010 is comprised of stuffing insertion block and BB scrambler.", "The stuffing insertion block can insert stuffing field into a payload of a BB frame.", "If the input data to the stream adaptation is sufficient to fill a BB-Frame.", "STUFFI is set to ‘0’ and the BBF has no stuffing field.", "Otherwise STUFFI is set to ‘1’ and the stuffing field is inserted immediately after the BBF header.", "The stuffing field comprises two bytes of the stuffing field header and a variable size of stuffing data.", "The BB scrambler scrambles complete BBF for energy dispersal.", "The scrambling sequence is synchronous with the BBF.", "The scrambling sequence is generated by the feed-back shift register.", "The PLS generation block 2020 can generate physical layer signaling (PLS) data.", "The PLS provides the receiver with a means to access physical layer DPs.", "The PLS data consists of PLS1 data and PLS2 data.", "The PLS1 data is a first set of PLS data carried in the FSS symbols in the frame having a fixed size, coding and modulation, which carries basic information about the system as well as the parameters needed to decode the PLS2 data.", "The PLS1 data provides basic transmission parameters including parameters required to enable the reception and decoding of the PLS2 data.", "Also, the PLS1 data remains constant for the duration of a frame-group.", "The PLS2 data is a second set of PLS data transmitted in the FSS symbol, which carries more detailed PLS data about the system and the DPs.", "The PLS2 contains parameters that provide sufficient information for the receiver to decode the desired DP.", "The PLS2 signaling further consists of two types of parameters, PLS2 Static data (PLS2-STAT data) and PLS2 dynamic data (PLS2-DYN data).", "The PLS2 Static data is PLS2 data that remains static for the duration of a frame-group and the PLS2 dynamic data is PLS2 data that may dynamically change frame-by-frame.", "Details of the PLS data will be described later.", "the PLS scrambler 2030 can scramble the generated PLS data for energy dispersal.", "The above-described blocks may be omitted or replaced by blocks having similar or identical functions.", "FIG.", "3 illustrates an input formatting block according to another embodiment of the present invention.", "The input formatting block illustrated in FIG.", "3 corresponds to an embodiment of the input formatting block 1000 described with reference to FIG.", "1.FIG.", "3 shows a mode adaptation block of the input formatting block when the input signal corresponds to multiple input streams.", "The mode adaptation block of the input formatting block for processing the multiple input streams can independently process the multiple input streams.", "Referring to FIG.", "3, the mode adaptation block for respectively processing the multiple input streams can include an input stream splitter 3000, an input stream synchronizer 3010, a compensating delay block 3020 a null packet deletion block 3030, a head compression block 3040, a CRC encoder 3050, BB frame slicer 3060 and a BB header insertion block 3070.Description will be given of each block of the mode adaptation block.", "Operations of the CRC encoder 3050.BB frame slicer 3060 and BB header insertion block 3070 correspond to those of the CRC encoder.", "BB frame slicer and BB header insertion block described with reference to FIG.", "2 and thus description thereof is omitted.", "The input stream splitter 3000 can split the input TS, IP, GS streams into multiple service or service component (audio, video, etc.)", "streams.", "The input stream synchronizer 3010 may be referred as ISSY.", "The ISSY can provide suitable means to guarantee Constant Bit Rate (CBR) and constant end-to-end transmission delay for any input data format.", "The ISSY is always used for the case of multiple DPs carrying TS, and optionally used for multiple DPs carrying GS streams.", "The compensating delay block 3020 can delay the split TS packet stream following the insertion of ISSY information to allow a TS packet recombining mechanism without requiring additional memory in the receiver.", "The null packet deletion block 3030, is used only for the TS input stream case.", "Some TS input streams or split TS streams may have a large number of null-packets present in order to accommodate VBR (variable bit-rate) services in a CBR TS stream.", "In this case, in order to avoid unnecessary transmission overhead, null-packets can be identified and not transmitted.", "In the receiver, removed null-packets can be re-inserted in the exact place where they were originally by reference to a deleted null-packet (DNP) counter that is inserted in the transmission, thus guaranteeing constant bit-rate and avoiding the need for time-stamp (PCR) updating.", "The head compression block 3040 can provide packet header compression to increase transmission efficiency for TS or IP input streams.", "Because the receiver can have a priori information on certain parts of the header, this known information can be deleted in the transmitter.", "For Transport Stream, the receiver has a-priori information about the sync-byte configuration (0x47) and the packet length (188 Byte).", "If the input TS stream carries content that has only one PID, i.e., for only one service component (video, audio, etc.)", "or service sub-component (SVC base layer, SVC enhancement layer, MVC base view or MVC dependent views), TS packet header compression can be applied (optionally) to the Transport Stream.", "IP packet header compression is used optionally if the input steam is an IP stream.", "The above-described blocks may be omitted or replaced by blocks having similar or identical functions.", "FIG.", "4 illustrates an input formatting block according to another embodiment of the present invention.", "The input formatting block illustrated in FIC.", "4 corresponds to an embodiment of the input formatting block 1000 described with reference to FIG.", "1.FIG.", "4 illustrates a stream adaptation block of the input formatting module when the input signal corresponds to multiple input streams.", "Referring to FIG.", "4, the mode adaptation block for respectively processing the multiple input streams can include a scheduler 4000, an I-Frame delay block 4010, a stuffing insertion block 4020, an in-band signaling 4030, a BB Frame scrambler 4040, a PLS generation block 4050 and a PLS scrambler 4060.Description will be given of each block of the stream adaptation block.", "Operations of the stuffing insertion block 4020, the BB Frame scrambler 4040, the PLS generation block 4050 and the PLS scrambler 4060 correspond to those of the stuffing insertion block, BB scrambler.", "PLS generation block and the PLS scrambler described with reference to FIG.", "2 and thus description thereof is omitted.", "The scheduler 4000 can determine the overall cell allocation across the entire frame from the amount of FECBLOCKs of each DP.", "Including the allocation for PLS, EAC and FIC, the scheduler generate the values of PLS2-DYN data, which is transmitted as in-band signaling or PLS cell in FSS of the frame.", "Details of FECBLOCK, EAG and FIC will be described later.", "The I-Frame delay block 4010 can delay the input data by one transmission frame such that scheduling information about the next frame can be transmitted through the current frame for in-band signaling information to be inserted into the DPs.", "The in-band signaling 4030 can insert un-delaycd part of the PLS2 data into a DP of a frame.", "The above-described blocks may be omitted or replaced by blocks having similar or identical functions.", "FIG.", "5 illustrates a BICM block according to an embodiment of the present invention.", "The BICM block illustrated in FIG.", "5 corresponds to an embodiment of the BICM block 1010 described with reference to FIG.", "1.As described above, the apparatus for transmitting broadcast signal for future broadcast services according to an embodiment of the present invention can provide a terrestrial broadcast service, mobile broadcast service.", "UHDTV service, etc.", "Since QoS (quality of service) depends on characteristics of a service provided by the apparatus for transmitting broadcast signals for future broadcast services according to an embodiment of the present invention, data corresponding to respective services needs to be processed through different schemes.", "Accordingly, the a BICM block according to an embodiment of the present invention can independently process DPs input thereto by independently applying SISO.", "MISO and MIMO schemes to the data pipes respectively corresponding to data paths.", "Consequently, the apparatus for transmitting broadcast signals for future broadcast services according to an embodiment of the present invention can control QoS for each service or service component transmitted through each DP.", "(a) shows the BICM block shared by the base profile and the handheld profile and (b) shows the BICM block of the advanced prolile.", "The BICM block shared by the base profile and the handheld profile and the BICM block of the advanced prolile can include plural processing blocks for processing each DP.", "A description will be given of each processing block of the BICM block for the base profile and the handheld profile and the BICM block for the advanced prolile.", "A processing block 5000 of the BICM block fur the base profile and the handheld profile can include a Data FEC encoder 5010, a bit interleaver 5020, a constellation mapper 5030, an SSD (Signal Space Diversity) encoding block 5040 and a time interleaver 5050.The Data FEC encoder 5010 can perform the FFC encoding on the input BBF to generate FECBLOCK procedure using outer coding (BCH), and inner coding (LDPC).", "The outer coding (BCH) is optional coding method.", "Details of operations of the Data FEC encoder 5010 will be described later.", "The bit interleaver 5020 can interleave outputs of the Data FEC encoder 5010 to achieve optimized performance with combination of the LDPC codes and modulation scheme while providing an efficiently impicmentable structure.", "Details of operations of the bit interleaver 5020 will be described later.", "The constellation mapper 5030 can modulate each ceil word from the bit interleaver 5020 in the base and the handheld profiles, or cell word from the Cell-word demultiplexer 5010-1 in the advanced profile using either QPSK.", "QAM-16, non-uniform QAM (NUQ-64, NUQ-256, NUQ-1024) or non-uniform constellation (NUC-16, NUC-64, NUC-256, NCC-1024) to give a power-normalized constellation point, el.", "This constellation mapping is applied only for DPs.", "Observe that QAM-16 and NUQs are square shaped, while NUCs have arbitrary shape.", "When each constellation is rotated by any multiple of 90 degrees, the rotated constellation exactly overlaps with its original one.", "This “rotation-sense” symmetric property makes the capacities and the average powers of the real and imaginary components equal to each other.", "Both NUQs and NUCs are defined specifically for each code rate and the particular one used is signaled by the parameter DP_MOD filed in PLS2 data.", "The SSD encoding block 5040 can precode cells in two (2D), three (3D), and four (4D) dimensions to increase the reception robustness under difficult fading conditions.", "The time interleaver 5050 can operates at the DP level.", "The parameters of time interleaving (TI) may be set differently for each DP.", "Details of operations of the time interleaver 5050 will be described later.", "A processing block 5000-1 of the BICM block for the advanced profile can include the Data FEC encoder, bit interleaver, constellation mapper, and time interleaver.", "However, the processing block 5000-1 is distinguished from the processing block 5000 further includes a cell-word demultiplexer 5010-1 and a MIMO encoding block 5020-1.Also, the operations of the Data FEC encoder, bit interleaver, constellation mapper, and time interleaver in the processing block 5000-1 correspond to those of the Data FEC encoder 5010, bit interleaver 5020, constellation mapper 5030, and time interleaver 5050 described and thus description thereof is omitted.", "The cell-word demultiplexer 5010-1 is used for the DP of the advanced profile to divide the single cell-word stream into dual cell-word streams for MIMO processing.", "Details of operations of the cell-word demultiplexer 5010-1 will be described later.", "The MIMO encoding block 5020-1 can processing the output of the cell-word demultiplexer 5010-1 using MIMO encoding scheme.", "The MIMO encoding scheme was optimized for broadcasting signal transmission.", "The MIMO technology is a promising way to get a capacity increase hut it depends on channel characteristics.", "Especially for broadcasting, the strong LOS component of the channel or a difference in the received signal power between two antennas caused by different signal propagation characteristics makes it difficult to get capacity gain from MIMO.", "The proposed MIMO encoding scheme overcomes this problem using a rotation-based pre-coding and phase randomization of one of the MIMO output signals.", "MIMO encoding is intended for a 2×2 MIMO system requiring at least two antennas at both the transmitter and the receiver.", "Two MIMO encoding modes are defined in this proposal; full-rate spatial multiplexing (FR-SM) and full-rate full-diversity spatial multiplexing (FRFD-SM).", "The FR-SM encoding provides capacity increase with relatively small complexity increase at the receiver side while the FRFD-SM encoding provides capacity increase and additional diversity gain with a great complexity increase at the receiver side.", "The proposed MIMO encoding scheme has no restriction on the antenna polarity configuration.", "MIMO processing is required for the advanced profile frame, which means all DPs in the advanced profile frame are processed by the MIMO encoder.", "MIMO processing is applied at DP level, Pairs of the Constellation Mapper outputs NUQ (e1, i and e2, i) are fed to the input of the MIMO Encoder.", "Paired MIMO Encoder output (g1, i and g2, i) is transmitted by the same carrier k and OFDM symbol I of their respective TX antennas.", "The above-described blocks may be omitted or replaced by blocks having similar or identical functions.", "FIG.", "6 illustrates a BICM block according to another embodiment of the present invention.", "The BICM block illustrated in FIG.", "6 corresponds to an embodiment of the BICM block 1010 described with reference to FIG.", "1.FIG.", "6 illustrates a BICM block for protection of physical layer signaling (PLS), emergency alert channel (EAC) and fast information channel (FIC).", "EAC is a part of a frame that carries EAS information data and FIC is a logical channel in a frame that carries the mapping information between a service and the corresponding base DP.", "Details of the EAC and FIC will be described later.", "Referring to FIG.", "6, the BICM block for protection of PLS, FEAC and FIC can include a PLS FEC encoder 6000, a bit interleaver 6010, and a constellation mapper 6020.Also, the PLS FEC encoder 6000 can include a scrambler.", "BCH encoding/zero insertion block, LDPC encoding block and LDPC parity punturing block.", "Description will be given of each block of the BICM block.", "The PLS FEC encoder 6000 can encode the scrambled PLS 1/2 data.", "EAC and FIC section.", "The scrambler can scramble PLS1 data and PLS2 data before BCH encoding and shortened and punctured LDPC encoding.", "The BCH encoding/zero insertion block can perform outer encoding on the scrambled PLS 1/2 data using the shortened BCH code for PLS protection and insert zero bits alter the BCH encoding.", "For PLS1 data only, the output bits of the zero insertion may be permuted before LDPC encoding.", "The LDPC encoding block can encode the output of the BCH encoding/zero insertion block using LDPC code.", "To generate a complete coded block.", "Cldpc, parity bits, Pldpc are encoded systematically from each zero-inserted PLS information block.", "Hdpc and appended after it.", "Cldpc=[IldpcPldpc]=[i0, i1, .", ".", ".", ", iKlpc−1, P0, P1, .", ".", ".", ", PNldpc−Kldpc−1] [Math Figure 1] The LDPC code parameters for PLS1 and PLS2 are as following table 4.TABLE 4 Signaling Kldpc code Type Ksig Kbch Nbch—parity (=Nbch) Nldpc Nldpc—parity rate Qldpc PLS1 342 1020 60 1080 4320 3240 1/4 36 PLS2 <1021 >1020 2100 2160 7200 5040 3/10 56 The LDPC parity punturing block can perform puncturing on the PUS1 data and PLS2 data.", "When shortening is applied to the PLS1 data protection, some LDPC parity bits are punctured after LDPC encoding.", "Also, for the PLS2 data protection, the LDPC parity bits of PLS2 are punctured after LDPC encoding.", "These punctured bits are not transmitted.", "The bit inlerleaver 6010 can interleave the each shortened and punctured PLS1 data and PLS2 data.", "The constellation mapper 6020 can map the bit interleaved PLS1 data and PLS2 data onto constellations.", "Tht above-described blocks may be omitted or replaced by blocks having similar or identical functions.", "FIG.", "7 illustrates a frame building block according to one embodiment of the present invention.", "The frame building block illustrated in FIG.", "7 corresponds to an embodiment of the frame building block 1020 described with reference to FIG.", "1.Referring to FIG.", "7, tlic frame building block can include a delay compensation block 7000, a cell mapper 7010 and a frequency interleaver 7020.Description will be given of each block of the frame building block.", "The delay compensation block 7000 can adjust the timing between the data pipes and the corresponding PLS data to ensure that they are co-timed at the transmitter end.", "The PLS data is delayed by the same amount as data pipes are by addressing the delays of data pipes caused by the Input Formatting block and BICM block.", "The delay of the BICM block is mainly due to the lime interleaver.", "In-band signaling data carries information of the next TI group so that they are carried one frame ahead of the DPS to be signaled.", "The Delay Compensating block delays in-band signaling data accordingly.", "The cell mapper 7010 can map PLS, EAC, FIC, DPs, auxiliary streams and dummy cells into the active carriers of the OFDM symbols in the frame.", "The basic function of the cell mapper 7010 is to map data cells produced by the TIs for each of the DPs, PLS cells, and EAC/FIC cells, if any, into arrays of active OFDM cells corresponding to each of the OFDM symbols within a frame.", "Service signaling data (such as PSI (program specific information)/SI) can be separately gathered and sent by a data pipe.", "The Cell Mapper operates according to the dynamic information produced by the scheduler and the configuration of the frame structure.", "Details of the frame will be described later.", "The frequency interleaver 7020 can randomly interleave data cells received from the cell mapper 7010 to provide frequency diversity.", "Also, the frequency interleaver 7020 can operate on very OFDM symbol pair comprised of two sequential OFDM symbols using a different inlerleaving-seed order to get maximum interleaving gain in a single frame.", "The above-described blocks may be omitted or replaced by blocks having similar or identical functions.", "FIG.", "8 illustrates an OFDM generation block according to an embodiment of the present invention.", "the OFDM generation block illustrated in FIG.", "8 corresponds to an embodiment of the OFDM generation block 1030 described with reference to FIG.", "1.The OFDM generation block modulates the OFDM carriers by the cells produced by the Frame Building block, inserts the pilots, and produces the lime domain signal for transmission.", "Also, this block subsequently inserts guard intervals, and applies PAPR (Peak-to-Average Power Radio) reduction processing to produce the final RF signal.", "Referring to FIG.", "8, the frame building block can include a pilot and reserved tone insertion block 8000, a 2D-eSFN encoding block 8010, an IFFT (Inverse Fast Fourier Transform) block 8020, a PAPR reduction block 8030, a guard interval insertion block 8040, a preamble insertion block 8050, other system insertion block 8060 and a DAC block 8070.Description will be given of each block of the frame building block.", "The pilot and reserved tone insertion block 8000 can insert pilots and the reserved tone.", "Various cells within the OFDM symbol are modulated with reference information, known as pilots, which have transmitted values known a priori in the receiver.", "The information of pilot cells is made up of scattered pilots, continual pilots, edge pilots FSS (frame signaling symbol) pilots and FES (frame edge symbol) pilots.", "Each pilot is transmitted at a particular boosted power level according to pilot type and pilot pattern.", "The value of the pilot information is derived from a reference sequence, which is a series of values, one for each transmitted carrier on any given symbol.", "The pilots can be used for frame synchronization, frequency synchronization, time synchronization, channel estimation, and transmission mode identification, and also can be used to follow the phase noise.", "Reference information, taken from the reference sequence, is transmitted in scattered pilot cells in every symbol except the preamble.", "FSS and FES of the frame.", "Continual pilots are inserted in every symbol of the frame.", "The number and location of continual pilots depends on both the FFT size and the scattered pilot pattern.", "The edge carriers are edge pilots in every symbol except for the preamble symbol.", "They are inserted in order to allow frequency interpolation up to the edge of the spectrum.", "FSS pilots are inserted in FSS(s) and FFS pilots are inserted in FES.", "They are inserted in order to allow time interpolation up to the edge of the frame.", "The system according to an embodiment of the present invention supports the SFN network, where distributed MISO scheme is optionally used to support very robust transmission mode.", "The 2D-eSFN is a distributed MISO scheme that uses multiple TX antennas, each of which is located in the different transmitter site in lite SFN network.", "The 2D-eSFN encoding block 8010 can process a 2D-eSFN processing to distorts the phase of the signals transmitted from multiple transmitters, in order to create both time and frequency diversity in the SFN configuration.", "Hence, burst errors due to low flat fading or deep-fading for a long time can be mitigated.", "The IFFT block 8020 can modulate the output from the 2D-eSFN encoding block 8010 using OFDM modulation scheme.", "Any cell in the data symbols which has not been designated as a pilot (or as a reserved tone) carries one of the data cells from the frequency interleaver.", "The cells are mapped to OFDM carriers.", "The PAPR reduction block 8030 can perform a PAPR reduction on input signal using various PAPR reduction algorithm in the time domain.", "The guard interval insertion block 8040 can insert guard intervals and the preamble insertion block 8050 can insert preamble in front of the signal.", "Details of a structure of the preamble will be described later.", "The other system insertion block 8060 can multiplex signals of a plurality of broadcast transmission/reception systems in the time domain such that data of two or more different broadcast transmission/reception systems providing broadcast services can be simultaneously transmitted in the same RF signal bandwidth.", "In this case, the two or more different broadcast transmission/reception systems refer to systems providing different broadcast services.", "The different broadcast services may refer to a terrestrial broadcast service, mobile broadcast service, etc.", "Data related to respective broadcast services can be transmitted through different frames.", "The DAC block 8070 can convert an input digital signal into an analog signal and output the analog signal.", "The signal output from the DAC block 7800 can be transmitted through multiple output antennas according to the physical layer profiles.", "A Tx antenna according to an embodiment of the present invention can have vertical or horizontal polarity.", "The above-described blocks may be omitted or replaced by blocks having similar or identical functions according to design.", "FIG.", "9 illustrates a structure of an apparatus for receiving broadcast signals for future broadcast services according to an embodiment of the present invention.", "The apparatus for receiving broadcast signals for future broadcast services according to an embodiment of the present invention can correspond to the apparatus for transmitting broadcast signals for future broadcast services, described with reference to FIG.", "1.The apparatus for receiving broadcast signals for future broadcast services according to an embodiment of the present invention can include a synchronization & demodulation module 9000, a frame parsing module 9010, a demapping & decoding module 9020, an output processor 9030 and a signaling decoding module 9040.A description will be given of operation of each module of the apparatus for receiving broadcast signals.", "The synchronization & demodulation module 9000 can receive input signals through in Rx antennas, perform signal detection and synchronization with respect to a system corresponding to the apparatus for receiving broadcast signals and carry out demodulation corresponding to a reverse procedure of the procedure performed by the apparatus for transmitting broadcast signals.", "The frame parsing module 9100 can parse input signal frames and extract data through which a service selected by a user is transmitted.", "If the apparatus for transmitting broadcast signals performs interleaving, the frame parsing module 9100 can carry out deinterleaving corresponding to a reverse procedure of interleaving.", "In this case, the positions of a signal and data that need to be extracted can be obtained by decoding data output from the signaling decoding module 9400 to restore scheduling information generated by the apparatus for transmitting broadcast signals.", "The demapping & decoding module 9200 can convert the input signals into bit domain data and then deinterlcave the same as necessary.", "The demapping & decoding module 9200 can perform demapping for mapping applied for transmission efficiency and correct an error generated on a transmission channel through decoding.", "In this case, the demapping & decoding module 9200 can obtain transmission parameters necessary for demapping and decoding by decoding the data output from the signaling decoding module 9400.The output processor 9300 can perform reverse procedures of various compression/signal processing procedures which are applied by the apparatus for transmitting broadcast signals to improve transmission efficiency.", "In this case, the output processor 9300 can acquire necessary control information from data output from the signaling decoding module 9400.The output of the output processor 8300 corresponds to a signal input to the apparatus for transmitting broadcast signals and may be MPEG-TSs.", "IP streams (v4 or v6) and generic streams.", "The signaling decoding module 9400 can obtain PLS information from the signal demodulated by the synchronization & demodulation module 9000.As described above, the frame parsing module 9100, demapping & decoding module 9200 and output processor 9300 can execute functions thereof using the data output from the signaling decoding module 9400.FIG.", "10 illustrates a frame structure according to an embodiment of the present invention.", "FIG.", "10 shows an example configuration of the frame types and FRUs in a super-frame, (a) shows a super frame according to an embodiment of the present invention, (b) shows FRU (Frame Repetition Unit) according to an embodiment of the present invention, (c) shows frames of variable PHY profiles in the FRU and (d) shows a structure of a frame.", "A super-frame may be composed of eight FRUs.", "The FRU is a basic multiplexing unit for TDM of the frames, and is repealed eight limes in a super-frame.", "Each frame in the FRU belongs to one of the PHY profiles, (base, handheld, advanced) or FEF.", "The maximum allowed number of the frames in the FRU is four and a given PHY profile can appear any number of times from zero limes to four times in the FRU (e.g., base, base, handheld, advanced).", "PHY profile definitions can be extended using reserved values of the PHY_PROFILE in the preamble, if required.", "The FEF part is inserted at the end of the FRU, if included.", "When the FEF is included in the FRU, the minimum number of FEFs is 8 in a super-frame.", "It is not recommended that FEF parts be adjacent to each other.", "One frame is further divided into a number of OFDM symbols and a preamble.", "As shown in (d), the frame comprises a preamble, one or more frame signaling symbols (FSS), normal data symbols and a frame edge symbol (FES).", "The preamble is a special symbol that enables fast Futurecast UTB system signal detection and provides a set of basic transmission parameters for efficient transmission and reception of the signal.", "The detailed description of the preamble will be will be described later.", "The main purpose of the FSS(s) is to carry the PLS data.", "For fast synchronisation and channel estimation, and hence fast decoding of PLS data, the FSS has more dense pilot pattern than the normal data symbol.", "The FES has exactly the same pilots as the FSS, which enables frequency-only interpolation within the FES and temporal interpolation, without extrapolation, for symbols immediately preceding the FES.", "FIG.", "11 illustrates a signaling hierarchy structure of the frame according to an embodiment of the present invention.", "FIG.", "11 illustrates the signaling hierarch structure, which is split into three main parts: the preamble signaling data 11000, the PUS1 data 11010 and the PLS2 data 11020.The purpose of the preamble, which is carried by the preamble symbol in every frame, is to indicate the transmission type and basic transmission parameters of that frame.", "The PLS1 enables the receiver to access and decode the PLS2 data, which contains the parameters to access the DP of interest.", "The PLS2 is carried in every frame and split into two main parts: PLS2-STAT data and PUS2-DYN data.", "The static and dynamic portion of PLS2 data is followed by padding, if necessary.", "FIG.", "12 illustrates preamble signaling data according to an embodiment of the present invention.", "Preamble signaling data carries 21 bits of information that are needed to enable the receiver to access PLS data and trace DPs within the frame structure.", "Details of the preamble signaling data are as follows: PHY_PROFILE: This 3-bit field indicates the PHY profile type of the current frame.", "The mapping of different PHY profile types is given in below table 5.TABLE 5 Value PHY profile 000 Base profile 001 Handheld profile 010 Advanced profiled 011~110 Reserved 111 FEF FFT_SIZE: This 2 bit field indicates the FFT size of the current frame within a frame-group, as described in below table 6.TABLE 6 Value FFT size 00 8K FFT 01 16K FFT 10 32K FFT 11 Reserved GI_FRACTION: This 3 bit field indicates the guard interval fraction value in ihe current super-frame, as described in below table 7.TABLE 7 Value GI_FRACTION 000 ⅕ 001 1/10 010 1/20 011 1/40 100 1/80 101 1/160 110~111 Reserved EAC_FLAG: This 1 bit field indicates whether the EAC is provided in the current frame.", "If this field is set to ‘1’ emergency alert service (EAS) is provided in the current frame.", "If this field set to ‘0’, EAS is not carried in the current frame.", "This field can be switched dynamically within a super-frame.", "PlLOT_MODE: This 1-bit field indicates whether the pilot mode is mobile mode or fixed mode for the current frame in the current frame-group.", "If this field is set to ‘0’, mobile pilot mode is used.", "If the field is set to ‘1’ the fixed pilot mode is used.", "PAPR_FLAG: This 1-bit field indicates whether PAPR reduction is used for the current frame in the current frame-group.", "If this field is set to value ‘1’, tone reservation is used for PAPR reduction.", "If this field is set to ‘0’.", "PAPR reduction is not used.", "FRU_CONFIGURE: This 3-bit field indicates the PHY profile type configurations of the frame repetition units (FRU) that are present in the current super-frame.", "All profile types conveyed in the current super-frame are identified in this field in ali preambles in the current super-frame.", "The 1-bit field has a different definition for each profile, as show in below table 8.TABLE 8 Current Current Current PHY_PROFILE = PHY_PROFILE = Current PHY_PROFILE = ‘001’ ‘010’ PHY_PROFILE = ‘000’ (base) (handheld) (advanced) ‘111’ (FEF) FRU_CONFIGURE = Only base Only handheld Only advanced Only FEF 000 profile profile present profile present present present FRU_CONFIGURE = Handheld profile Base profile Base profile Base profile 1XX present present present present FRU_CONFIGURE = Advanced Advanced Handheld profile Handheld profile X1X profile profile present present present present FRU_CONFIGURE = FEF FEF FEF Advanced XX1 present present present profile present RESERVED: This 7-bit field is reserved for future use.", "FIG.", "13 illustrates PLS1 data according to an embodiment of the present invention.", "PLS1 data provides basic transmission parameters including parameters required to enable the reception and decoding of the PLS2.As above mentioned, the PLS1 data remain unchanged for the entire duration of one frame-group.", "The detailed definition of the signaling fields of the PLS1 data are as follows: PREAMBLE_DATA: This 20-bit field is a copy of the preamble signaling data excluding the EAC_FLAG.", "NUM_FRAME_FRU: This 2-bit field indicates the number of the frames per FRU.", "PAYLOAD_TYPE: This 3-bit field indicates the format of the payload data carried in the frame-group.", "PAYLOAD_TYPE is signaled as shown in table 9.TABLE 9 value Payload type 1XX TS stream is transmitted X1X IP stream is transmitted XX1 GS stream is transmitted NUM_FSS: This 2-bit field indicates the number of FSS symbols in the current frame.", "SYSTEM_VERSION: This 8-bit field indicates the version of the transmitted signal format.", "The SYSTEM_VERSION is divided into two 4-bit fields, which are a major version and a minor version.", "Major version: The MSB four bits of SYSTEM_VERSION field indicate major version information.", "A change in the major version field indicates a non-backward-compatible change.", "The default value is ‘0000’.", "For the version described in this standard, the value is set to ‘0000’.", "Minor version: The LSB four bits of SYSTEM_VERS10N field indicate minor version information.", "A change in the minor version field is backward-compatible.", "CELL_ID: This is a 16-bit field which uniquely identifies a geographic cell in an ATSC network.", "An ATSC cell coverage area may consist of one or more frequencies, depending on the number of frequencies used per Futurecast UTB system.", "If the value of ihe CELL_ID is not known or unspecified, this field is set to ‘0’.", "NETWORK_ID: This is a 16-bit field which uniquely identifies the current ATSC network.", "SYSTEM_ID: This 16-bit field uniquely identifies the Futurecast UTB system within the ATSC network.", "The Futurecast UTB system is the terrestrial broadcast system whose input is one or more input streams (TS, IP, GS) and whose output is an RF signal The Futurecast UTB system carries one or more PHY profiles and FEF, if any.", "The same Futurecast UTB system may carry different input streams and use different RF frequencies in different geographical areas, allowing local service insertion.", "The frame structure and scheduling is controlled in one place and is identical for all transmissions within a Futurecast UTB system.", "One or more Futurecast UTB systems may have the same SYSTEM_ID meaning that they all have the same physical layer structure and configuration.", "The following loop consists of FRU_PHY_PROFILE, FRU_FRAME_LENGTH, FRU_GI_FRACTION, and RESERVED which are used to indicate the FRU configuration and the length of each frame type.", "The loop size is fixed so that four PHY profiles (including a FEF) are signaled within the FRU.", "If NUM_FRAME_FRU is less than 4, the unused fields are filled with zeros.", "FRU_PHY_PROFILE: This 3-bit field indicates the PHY profile type of the (i+1)th (i is the loop index) frame of the associated FRU.", "This field uses the same signaling format as shown in the table 8.FRU_FRAME_LENGTH: This 2-bit field indicates the length of the (i+1)th frame of the associated FRU.", "Using FRU_FRAME_LENGTH together with FRU_GI_FRACTION, the exact value of the frame duration can be obtained.", "FRU_GI_FRACTION: This 3-bit field indicates the guard interval fraction value of the (i+1)h frame of the associated FRU.", "FRU_GI_FRACTION is signaled according to the table 7.RESERVED: This 4-bit field is reserved for future use.", "The following fields provide parameters for decoding the PLS2 data.", "PLS2_FEC_TYPE: This 2-bit field indicates the FEC type used by the PLS2 protection.", "The FEC type is signaled according to table 10.The details of the LDPC codes will be described later.", "TABLE 10 Content PLS2 FEC type 00 4K-1/4 and 7K-3/10 LDPC codes 01~11 Reserved PLS2_MOD: this 3-bit field indicates the modulation type used by the PLS2, The modulation type is signaled according to table 11.TABLE 11 Value PLS2_MODE 000 BPSK 001 QPSK 010 QAM-16 011 NUQ-64 100~111 Reserved PLS2_SIZE_CELL: This 15-bit field indicates Ctotal_partial_block, the size (specified as the number of QAM cells) of the collection of full coded blocks for PLS2 that is carried in the current frame-group.", "This value is constant during the entire duration of the current frame-group.", "PLS2_STAT_SIZE_BIT: This 14-bit field indicates the size, in bits, of the PLS2-STAT for the current frame-group.", "This value is constant during the entire duration of the current frame-group.", "PLS2_DYN _SIZE_BIT: This 14-bit field indicates the size, in bits, of the PLS2-DYN for the current frame-group.", "This value is constant during the entire duration of the current frame-group.", "PLS2_REP_FLAG: This 1-bit flag indicates whether the PLS2 repetition mode is used in the current frame-group.", "When this field is set to value ‘1’, the PLS2 repetition mode is activated.", "When this field is set to value ‘0’, the PLS2 repetition mode is deactivated.", "PLS2_REP_S1ZE_CELL; This 15-bit field indicates Ctotal_partial_block, the size (specified as the number of QAM cells) of the collection of partial coded blocks for PLS2 carried in every frame of the current frame-group, when PLS2 repetition is used.", "If repetition is not used, the value of this field is equal to 0.This value is constant during the entire duration of the current frame-group.", "PLS2_NEXT_FEC_TYPE: This 2-bit field indicates the FEC type used for PLS2 that is carried in every frame of the next frame-group.", "The FEC type is signaled according to the table 10.PLS2_NEXT_MOD: This 3-bit field indicates the modulation type used for PLS2 that is carried in every frame of the next frame-group.", "The modulation type is signaled according to the table 11.PLS2_NEXT_REP_FLAG: This 1-bit flag indicates whether the PLS2 repetition mode is used in the next frame-group.", "When this field is set to value ‘1’.", "the PLS2 repetition mode is activated.", "When this field is set to value ‘0’, the PLS2 repetition mode is deactivated.", "PLS2_NEXT_REP_SIZE_CELL: This 15-bit field indicates Ctotal_full_block, The size (specified as the number of QAM ceils) of the collection of full coded blocks for PLS2 that is carried in every frame of the next frame-group, wtien PLS2 repetition is used.", "If repetition is not used in the next frame-group, the value of this field is equal to 0.This value is constant during the entire duration of the current frame-group.", "PLS2_NEXT_REP_STAT_SIZE_BIT: This 14-bit field indicates the size, in bits, of the PLS2-STAT for the next frame-group.", "This value is constant in the current frame-group.", "PLS2_NEXT_REP_DYN_SIZE_BIT: This 14-bit field indicates the size, in bits, of the PLS2-DYN for the next frame-group.", "This value is constant in the current frame-group.", "PLS2 AP_MODE: This 2-bit field indicates whether additional parity is provided for PLS2 in the current frame-group.", "This value is constant during the entire duration of the current frame-group.", "The below table 12 gives the values of this field.", "When this field is set to ‘00’, additional parity is not used for the PLS2 in the current frame-group.", "TABLE 12 Value PLS2-AP mode 00 AP is not provided 01 AP1 mode 10~11 Reserved PLS2_AF_SIZE_CELL: This 15-bit field indicates the size (specified as the number of QAM cells) of the additional parity bits of the PLS2.This value is constant during the entire duration of the current frame-group.", "PLS2_NEXT_AP_MODE: This 2-bit field indicates whether additional parity is provided for PLS2 signaling in every frame of next frame-group.", "This value is constant during the entire duration of the current frame-group.", "The table 12 defines the values of this field PLS2_NEXT_AP_SIZE_CELL: This 15-bit field indicates the size (specified as the number of QAM cells) of the additional parity bits of the PLS2 in every frame of the next frame-group.", "This value is constant during the entire duration of the current frame-group.", "RESERVED: This 32-bit field is reserved for future use.", "CRC_32: A 32-bit error detection code, which is applied to the entire PLS1 signaling.", "FIG.", "14 illustrates PLS2 data according to an embodiment of the present invention.", "FIG.", "14 illustrates PLS2-STAT data of the PLS2 data.", "The PLS2-STAT data are the same within a frame-group, while the PLS2-DYN data provide information that is specific for the current frame.", "The details of fields of the PLS2-STAT data are as follows; FIC_FLAG: This 1-bit field indicates whether the FIC is used in the current frame-group.", "If this field is set to ‘1’, the FIC is provided in the current frame.", "If this field set to ‘0’, the FIC is not carried in the current frame.", "This value is constant during the entire duration of the current frame-group.", "AUX_FLAG: this 1-bit field indicates whether the auxiliary stream(s) is used in the current frame-group.", "If this field is set to ‘1’, the auxiliary stream is provided in the current frame.", "If this field set to ‘0’, the auxiliary stream is not carried in the current frame.", "This value is constant during the entire duration of current frame-group.", "NUM_DP: This 6-bit field indicates the number of DPs carried within the current frame.", "The value of this field ranges from 1 to 64, and the number of DPs is NUM_DP+1.DP_ID: This 6-bit field identifies uniquely a DP within a PHY profile.", "DP_TYPE: This 3-bit field indicates the type of the DP.", "This is signaled according to the below table 13.TABLE 13 Value DP Type 000 DP Type 1 001 DP Type 2 010~111 reserved DP_GROUP_ID: This 8-bit field identifies the DP group with which the current DP is associated.", "This can be used by a receiver to access the DPs of the service components associated with a particular service, which will have the same DP_GROUP_ID.", "BASE_DP_ID: This 6-bit field indicates the DP carrying service signaling data (such as PSI/SI) used in the Management layer.", "The DP indicated by BASE_DP_ID may be either a normal DP carrying the service signaling data along with the service data or a dedicated DP carrying only the service signaling data DP_FEC_TYPE: This 2-bit field indicates the FEC type used by the associated DP.", "The FEC type is signaled according to the below table 14.TABLE 14 Value FEC_TYPE 00 16K LDPC 01 64K LDPC 10~11 Reserved DP_COD: This 4-bit field indicates the code rate used by the associated DP.", "The code rate is signaled according to the below table 15.TABLE 15 Value Code rate 0000 5/15 0001 6/15 0010 7/15 0011 8/15 0100 9/15 0101 10/15 0110 11/15 0111 12/15 1000 13/15 1001~1111 Reserved DP_MOD: This 4-bit field indicates the modulation used by the associated DP.", "The modulation is signaled according to the below table 16.TABLE 16 Value Modulation 0000 QPSK 0001 QAM-16 0010 NUQ-64 0011 NUQ-256 0100 NUQ-1024 0101 NUC-16 0110 NUC-64 0111 NUC-256 1000 NUC-1024 1001~1111 reserved DP_SSD_FLAG: This 1-bit field indicates whether the SSD mode is used in the associated DP.", "If this field is set to value ‘1’, SSD is used.", "If this field is set to value ‘0’, SSD is not used.", "The following field appears only if PHY_PROFILE is equal to ‘010’, which indicates the advanced profile: DP_MIMO: This 3-bit fieid indicates which type of MIMO encoding process is applied to the associated DP.", "The type of MIMO encoding process is signaled according to the table 17.TABLE 17 Value MIMO encoding 000 FR-SM 001 FRFD-SM 010~111 reserved DP_TI_TYPE: This 1-bit field indicates the type of time-interleaving.", "A value of ‘0’ indicates that one TI group corresponds to one frame and contains one or more TI-blocks.", "A value of ‘1’ indicates that one TI group is carried in more than one frame and contains only one TI-block.", "DP_TI_LENGTH: The use of this 2-bit field (the allowed values are only 1, 2, 4, 8) is determined by the values set within the DP_TI_TYPE field as follows: If the DP_TI_TYPE is set to the value ‘1’, this field indicates PI, the number of the frames to which each TI group is mapped and there is one TI-block per TI group (NTI=I).", "The allowed PI values with 2-bit field are defined in the below table 18.If the DP_TI_TYPE is set to the value ‘0’, this field indicates the number of TI-blocks NTI per TI group, and there is one TI group per frame (PI=I).", "The allowed PI values with 2-bit field are defined in the below table 18.TABLE 18 2-bit field PI NTI 00 1 1 01 2 2 10 4 3 11 8 4 DP_FRAME_INTERVAL: This 2-bit field indicates the frame interval (UUMP) within the frame-group for the associated DP and the allowed values are 1, 2, 4, 8 (the corresponding 2-bit field is ‘00’, ‘01’, ‘10’, or ‘11’, respectively).", "For DPs that do not appear every frame of the frame-group, the value of this field is equal to the interval between successive frames.", "For example, if a DP appears on the frames 1, 5, 9, 13, etc., this field is set to ‘4’.", "For DPs that appear in every frame, this field is set to ‘1’.", "DP_TI_BYPASS: This 1-bit field determines the availability of time interleaver.", "If time interleaving is not used for a DP, it is set to ‘1’.", "Whereas if time interleaving is used it is set to ‘0’.", "DP_FIRST_FRAME_IDX: This 5-bit field indicates the index of the first frame of the super-frame in which the current DP occurs.", "The value of DP_FIRST_FRAME_IDX ranges from 0 to 31 DP_NUM_BLOCK_MAX: This 10-bit field indicates the maximum value of DP_NUM_BLOCKS for this DP.", "The value of this field has the same range as DP_NUM_BLOCKS.", "DP _PAYLOAD_TYPE: This 2-bit field indicates the type of the payload data carried by the given DP.DP_PAYLOAD_TYPE is signaled according to the below table 19.TABLE 19 Value Payload Type 00 TS 01 IP 10 GS 11 reserved DP_INBAND_DEMODE: This 2-bit field indicates whether the current DP carries in-band signaling information.", "The in-band signaling type is signaled according to the below table 20.TABLE 20 Value In-band mode 00 In-band signaling is not carried.", "01 INBAND-PLS is carried only 10 INBAND-ISSY is carried only 11 INBAND-PLS and INBAND-ISSY are carried DP_PROTOCOL_TYPE: This 2-bit field indicates the protocol type of the payload carried by the given DP.", "It is signaled according to the below table 21 when input payload types are selected.", "TABLE 21 If DP_PAYLOAD_TYPE If DP_PAYLOAD_TYPE If DP_PAYLOAD_TYPE Value Is TS Is IP Is GS 00 MPEG2-TS IPv4 (Note) 01 Reserved IPv6 Reserved 10 Reserved Reserved Reserved 11 Reserved Reserved Reserved DNP_CRC_MODE: This 2-bit field indicates whether CRC encoding is used in the Input Formatting block.", "The CRC mode is signaled according to the below table 22.TABLE 22 Value CRC mode 00 Not used 01 CRC-8 10 CRC-16 11 CRC-32 DNP_MODE: This 2-bit field indicates the null-packet deletion mode used by the associated DP when DP_PAYLOAD_TYPE is set to TS (‘00’).", "DNP_MODE is signaled according to the below table 23.If DP_PAYLOAD_TYPE is not TS (‘00’), DNP_MODE is set to the value ‘00’.", "TABLE 23 Value Null-packet deletion mode 00 Not used 01 DNP-NORMAL 10 DNP-OFFSET 11 reserved ISSY_MODE This 2-bit field indicates the ISSY mode used by the associated DP when DP_PAYLOAD_TYPE is set to TS (‘00’).", "The ISSY_MODE is signaled according to the below table 24 If DP_PAYLOAD_TYPE is not TS (‘00’).", "ISSY_MODE is set to the value ‘00’.", "TABLE 24 Value ISSY mode 00 Not used 01 ISSY-UP 10 ISSY-BBF 11 reserved HC_MODE_TS: This 2-bit field indicates the TS header compression mode used by thc associated DP when DP_PAYLOAD_TYPE is set to TS (‘00’).", "The HC_MODE_TS is signaled according to the below table 25.TABLE 25 Value Header compression mode 00 HC_MODE_TS 1 01 HC_MODE_TS 2 10 HC_MODE_TS 3 11 HC_MODE_TS 4 HC_MODE_IP: This 2-bit field indicates the IP header compression mode when DP_PAYLOAD_TYPE is set to IP (‘01’) The HC_MODE_IP is signaled according to the below table 26.TABLE 26 Value Header compression mode 00 No compression 01 HC_MODE_IP 1 10~11 reserved PID: This 13-bit field indicates the PID number for TS header compression when DP_PAYLOAD_TYPE is set to TS (‘00’) and HC_MODE_TS is set ‘01’ or ‘10’.", "RESERVED: This 8-bit field is reserved for future use.", "The following field appears only if FIC_FLAG is equal to ‘1’: FIC_VERSION: This 8-bit field indicates the version number of the FIC.", "FIC_LENGTH_BYTE: This 13-bit field indicates the length, in bytes, of the FIC.", "RESERVED: This 8-bit field is reserved for future use.", "The following field appears only if AUX_FLAG is equal to ‘1’: NUM_AUX: This 4-bit field indicates the number of auxiliary streams.", "Zero means no auxiliary streams are used.", "AUX_CONFIG_RFU: This 8-bit field is reserved for future use.", "AUX_STREAM_TYPE: This 4-bit is reserved for future use for indicating the type of the current auxiliary stream.", "AUX_PRIVATE_CONFIG: This 28-bit field is reserved for future use for signaling auxiliary streams.", "FIG.", "15 illustrates PLS2 data according to another embodiment of the present invention.", "FIG.", "15 illustrates PLS2-DYN data of the PLS2 data.", "The values of the PLS2-DYN data may change during the duration of one frame-group, while the size of fields remains constant.", "The details of fields of the PLS2-DYN data are as follows: FRAME_INDEX: This 5-bit field indicates the frame index of the current frame within the super-frame.", "The index of the first frame of the super-frame is set to ‘0’.", "PLS_CHANGE_COUNTER: This 4-bit field indicates the number of super-frames ahead where the configuration will change.", "The next super-frame with changes in the configuration is indicated by the value signaled within this field.", "If this field is set to the value ‘0000’, it means that no scheduled change is foreseen: e.g., value ‘1’ indicates that there is a change in the next super-frame.", "FIC_CHANGE_COUNTER: This 4-bit field indicates the number of super-frames ahead where the configuration (i.e., the contents of the FIC) will change.", "The next super-frame with changes in the configuration is indicated by the value signaled within this field.", "If this field is set to the value ‘0000’, it means that no scheduled change is foreseen: e.g.", "value ‘0001’ indicates that there is a change in the next super-frame.", "RESERVED: This 16-bit field is reserved for future use.", "The following fields appear in the loop over NUM_DP, which describe the parameters associated with the DP earned in the current frame.", "DP_ID: This 6-bit field indicates uniquely the DP within a PHY profile.", "DP_START: This 15-bit (or 13-bit) field indicates the start position of the first of the DPs using the DPU addressing scheme.", "The DP_START field has differing length according to the PHY profile and FFT size as shown in the below table 27.TABLE 27 DP_START field size PHY profile 64K 16K Base 13 bit 15 bit Handheld — 13 bit Advanced 13 bit 15 bit DP_NUM_BLOCK: This 10-bit field indicates the number of FEC blocks in the current TI group for the current DP.", "The value of DP_NUM_BLOCK ranges from 0 to 1023 RESERVED: This 8-bit field is reserved for future use.", "The following fields indicate the FIC parameters associated with the EAC.", "EAC_FLAG: This 1-bit field indicates the existence of the EAC in the current frame.", "This bit is the same value as the EAC_FLAG in the preamble.", "EAS_WAKE_UP_VERSION_NUM: This 8-bit field indicates the version number of a wake-up indication.", "If the EAC_FLAG field is equal to ‘1’, the following 12 bits are allocated for EAC_LENGTH_BYTE field.", "If the EAC_FLAG field is equal to ‘0’, the following 12 bits are allocated for EAC_COUNTER.", "EAC_LENGTH_BYTE: This 12-bit field indicates the length, in byte, of the EAC.", "EAC_COUNTER: This 12-bit field indicates the number of the frames before the frame where the EAC arrives.", "The following field appears only if the AUX_FLAG field is equal to ‘1’: AUX_PRIVATE_DYN: This 48-bit field is reserved for future use for signaling auxiliary streams.", "The meaning of this field depends on the value of AUX_STREAM_TYPE, in the configurable PLS2-STAT.", "CRC_32: A 32-bit error detection code, which is applied to the entire PLS2.FIG.", "16 illustrates a logical structure of a frame according to an embodiment of the present invention.", "As above mentioned, the PLS, EAC, FIC.", "DPs, auxiliary streams and dummy cells are mapped into the active carriers of the OFDM symbols in the frame.", "The PLS1 and PLS2 are first mapped into one or more FSS(s).", "After that, EAC cells, if any, are mapped immediately following the PLS field, followed next by FIC cells, if any.", "The DPs are mapped next after the PLS or EAC, FIC, if any.", "Type 1 DPs follows first, and Type 2 DPs next.", "The details of a type of the DP will be described later.", "In some case, DPs may carry some special data for EAS or service signaling data.", "The auxiliary stream or streams, if any, follow the DPs, which in turn are followed by dummy cells.", "Mapping them all together in the above mentioned order, i.e.", "PLS, EAC, FIC.", "DPs, auxiliary streams and dummy data cells exactly fill the cell capacity in the frame.", "FIG.", "17 illustrates PLS mapping according to an embodiment of the present invention.", "PLS cells are mapped to the active carriers of FSS(s).", "Depending on the number of cells occupied by PLS, one or more symbols are designated as FSS(s), and the number of FSS(s) NFSS is signaled by NUM_FSS in PLS1.The FSS is a special symbol for carrying PLS cells.", "Since robustness and latency are critical issues in the PLS, the FSS(s) has higher density of pilots allowing fast synchronization and frequency-only interpolation within the FSS.", "PLS cells are mapped to active carriers of the NFSS FSS(s) in a top-down manner as shown in an example in FIG.", "17.The PLS1 cells are mapped first from the first cell of the first FSS in an increasing order of the cell index.", "The PLS2 cells follow immediately after the last cell of the PLS1 and mapping continues downward until the last cell index of the first FSS.", "If the total number of required PLS cells exceeds the number of active carriers of one FSS, mapping proceeds to the next FSS and continues in exactly the same manner as the first FSS.", "After PLS mapping is completed, DPs are carried next.", "If EAC, FIC or both are present in the current frame, they are placed between PLS and “normal” DPs.", "FIG.", "18 illustrates EAC mapping according to an embodiment of the present invention.", "EAC is a dedicated channel for carrying EAS messages and links to the DPs for EAS.", "EAS support is provided but EAC itself may or may not be present in every frame.", "EAC, if any, is mapped immediately after the PLS2 cells.", "EAC is not preceded by any of the FIC.", "DPs, auxiliary streams or dummy cells other than the PLS cells.", "The procedure of mapping the EAC cells is exactly the same as that of the PLS.", "The EAC cells are mapped from the next cell of the PLS2 in increasing order of the cell index as shown m the example in FIG.", "18.Depending on the EAS message size, EAC cells may occupy a few symbols, as shown in FIG.", "18.EAC cells follow immediately after the last cell of the PLS2, and mapping continues downward until the last cell index of the last FSS.", "If the total number of required EAC cells exceeds the number of remaining active carriers of the last FSS mapping proceeds to the next symbol and continues in exactly the same manner as FSS(s).", "The next symbol for mapping in this case is the normal data symbol, which has more active carriers than a FSS.", "After EAC mapping is completed, the FIC is carried next, if any exists.", "If FIC is not transmitted (as signaled in the PLS2 field), DPs follow immediately after the last cell of the EAC.", "FIG.", "19 illustrates FIC mapping according to an embodiment of the present invention.", "(a) shows an example mapping of FIC cell without EAC and (b) shows an example mapping of FIC cell with EAC.", "FIC is a dedicated channel for carrying cross-layer information to enable fast service acquisition and channel scanning.", "This information primarily includes channel binding information between DPs and the services of each broadcaster.", "For fast scan, a receiver can decode FIC and obtain information such as broadcaster ID, number of services, and BASE_DP_ID.", "For fast service acquisition, in addition to FIC, base DP can be decoded using BASE_DP_ID.", "Other than the content it carries, a base DP is encoded and mapped to a frame in exactly the same way as a normal DP.", "Therefore, no additional description is required for a base DP.", "The FIC data is generated 3nd consumed in the Management Layer.", "The content of FIC data is as described in the Management Layer specification.", "The FIC data is optional and the use of FIC is signaled by the FIC_FLAG parameter in the static part of the PLS2.If FIC is used, FIC_FLAG is set to ‘1’ and the signaling field for FIC is defined in the static part of PLS2.Signaled in this field are FIC_VERSION, and FIC_LENGTH_BYTE.", "FIC uses the same modulation, coding and time interleaving parameters as PLS2.FIC shares the same signaling parameters such as PLS2_MOD and PLS2_FEC.", "FIC data, if any, is mapped immediately after PLS2 or EAC if any.", "FIC is not preceded by any normal DPs, auxiliary streams or dummy cells.", "The method of mapping FIC cells is exactly the same as that of EAC which is again the same as PLS.", "Without EAC after PLS, FIC cells are mapped from the next cell of the PLS2 in an increasing order of the cell index as shown in an example in (a).", "Depending on the FIC data size, FIC cells may be mapped over a few symbols, as shown in (b).", "FIC cells follow immediately afler the last cell of the PLS2, and mapping continues downward until the last cell index of the last FSS.", "If the total number of required FIC cells exceeds the number of remaining active carriers of the last FSS, mapping proceeds to the next symbol and continues in exactly the same manner as FSS(s).", "The next symbol for mapping in this case is the normal data symbol which has more active carriers than a FSS.", "If EAS messages are transmitted in the current frame, EAC precedes FIC, and FIC cells are mapped from the next cell of the EAC in an increasing order of the cell index as shown in (b).", "After FIC mapping is completed, one or more DPS are mapped, followed by auxiliary streams, if any, and dummy cells.", "FIG.", "20 illustrates a type of DP according to an embodiment of the present invention.", "(a) shows type 1 DP and (b) shows type 2 DP.", "After the preceding channels, i.e., PLS, EAC and FIC, are mapped, cells of the DPs are mapped.", "A DP is categorized into one of two types according to mapping method: Type 1 DP: DP is mapped by TDM Type 2 DP: DP is mapped by FDM The type of DP is indicaied by DP_TYPE field in the static part of PLS2.FIG.", "20 illustrates the mapping orders of Type 1 DPs and Type 2 DPs.", "Type 1 DPs are first mapped in the increasing order of cell index, and then after reaching the last cell index, the symbol index is increased by one.", "Within the next symbol, the DP continues to be mapped in the increasing order of cell index starting from p=0.With a number of DPs mapped together in one frame, each of the Type 1 DPs are grouped in time, similar to TDM multiplexing of DPs.", "Type 2 DPs are first mapped in the increasing order of symbol index, and then after reaching the last OFDM symbol of the frame, the cell index increases by one and the symbol index rolls back to the first available symbol and then increases from that symbol index.", "After mapping a number of DPs together in one frame, each of the Type 2 DPs are grouped in frequency together, similar to FDM multiplexing of DPS.", "Type 1 DPs and Type 2 DPs can coexist in a frame if needed with one restriction; Type 1 DPS always precede Type 2 DPs.", "The total number of OFDM cells carrying Type 1 and Type 2 DPs cannot exceed the total number of OFDM cells available for transmission of DPs: DDP1+DDP2≤DDP [Math Figure 2] where DDP1 is the number of OFDM cells occupied by Type 1 DPs.", "DDP2 is the number of cells occupied by Type 2 DPs.", "Since PLS, EAC, FIC are all mapped in the same way as Type 1 DP, they all follow “Type 1 mapping rule”.", "Hence, overall, Type 1 mapping always precedes Type 2 mapping.", "FIG.", "21 illustrates DP mapping according to an embodiment of the present invention.", "(a) shows an addressing of OFDM cells for mapping type 1 DPs and (b) shows an addressing of OFDM cells for mapping for type 2 DPs.", "Addressing of OFDM cells for mapping type 1 DPs (0, .", ".", ".", ", DDP1-1) is defined for the active data cells of Type 1 DPs.", "The addressing scheme defines the order in which the cells from the TIs for each of the Type 1 DPs are allocated to the active data cells.", "It is also used to signal the locations of the DPs in the dynamic part of the PLS2.Without EAC and FIC, address 0 refers to the cell immediately following the last cell carrying PLS in the last FSS.", "If EAC is transmitted and FIC is not in the corresponding frame, address 0 refers to the cell immediately following the last cell carrying EAC.", "If FIC is transmitted in the corresponding frame, address 0 refers to the cell immediately following the last cell carrying FIC.", "Address 0 for Type 1 DPs can be calculated considering two different cases as shown in (a).", "In the example in (a), PLS, EAC and FIC are assumed to be all transmitted.", "Extension to the cases where either or both of EAC and FIC are omitted is straightforward.", "If there are remaining celts in the FSS after mapping all the cells up to FIC as shown on the left side of (a).", "Addressing of OFDM cells for mapping Type 2 DPs (0, .", ".", ".", ", DDP2-1) is defined for the active data cells of Type 2 DPs.", "The addressing scheme defines the order in which the cells from the TIs for each of the Type 2 DPs are allocated to the active data cells.", "It is also used to signal the locations of the DPs in the dynamic part of the PLS2.Three slightly different cases are possible as shown in (b).", "For the first case shown on the left side of (b), cells in the last FSS are available for Type 2 DP mapping.", "For the second case shown in the middle, FIC occupies cells of a normal symbol, but the number of FIC cells on that symbol is not larger than CFSS.", "The third case, shown on the right side in (b), is the same as the second case except that the number of FIC cells mapped on that symbol exceeds CFSS.", "The extension to the case where Type 1 DP(s) precede Type 2 DP(s) is straightforward since PLS.", "EAC and FIC follow the same “Type 1 mapping rule” as the Type 1 DP(s).", "A data pipe unit (DPU) is a basic unit for allocating data cells to a DP in a frame.", "A DPU is defined as a signaling unit for locating DPs in a frame.", "A Cell Mapper 7010 may map the cells produced by the TIs for each of the DPs.", "A Time interleaver 5050 outputs a series of TI-blocks and each TI-block comprises a variable number of XFECBLOCKs which is in turn composed of a set of cells.", "The number of cells in an XFECBLOCK, Ncells, is dependent on the FECBLOCK size, Nldpc, and the number of transmitted bits per constellation symbol.", "A DPU is defined as the greatest common divisor of all possible values of the number of cells in a XFECBLOCK, Ncells, supported in a given PHY profile.", "The length of a DPU in cells is defined as LDPU.", "Since each PHY profile supports different combinations of FECBLOCK size and a different number of bits per constellation symbol, LDPU is defined on a PHY profile basis.", "FIG.", "22 illustrates an FEC structure according to an embodiment of the present invention.", "FIG.", "22 illustrates an FEC structure according to an embodiment of the present invention before bit interleaving.", "As above mentioned, Data FEC encoder may perform the FEC encoding on the input BBF to generate FECBLOCK procedure using outer coding (BCH), and inner coding (LDPC).", "The illustrated FEC structure corresponds to the FECBLOCK.", "Also, the FECBLOCK and the FEC structure have same value corresponding to a length of LDPC codeword.", "The BCH encoding is applied to each BBF (Kbeh bits), and then LDPC encoding is applied to BCH-encoded BBF (Kldpc bits=Nbch bits) as illustrated in FIG.", "22.The value of Nldpc is either 64800 bits (long FECBLOCK) or 16200 bits (short FECBLOCK).", "The below table 28 and table 29 show FEC encoding parameters for a long FECBLOCK and a short FECBLOCK respectively.", "TABLE 28 BCH error LDPC correction Nbch − Rate Nldpc Kldpc Kbch capability Kbch 5/15 64800 21600 21408 12 192 6/15 25920 25728 7/15 30240 30048 8/15 34560 34368 9/15 38880 38688 10/15 43200 43008 11/15 47520 47328 12/15 51840 51648 13/15 56160 55968 TABLE 29 BCH error LDPC correction Nbch − Rate Nldpc Kldpc Kbch capability Kbch 5/15 16200 5400 5232 12 168 6/15 6480 6312 7/15 7560 7392 8/15 8640 8472 9/15 9720 9552 10/15 10800 10632 11/15 11880 11712 12/15 12960 12792 13/15 14040 13872 The details of operations of the BCH encoding and LDPC encoding are as follows: A 12-error correcting BCH code is used for outer encoding of the BBF.", "The BCH generator polynomial for short FECBLQCK and long FECBLOCK are obtained by multiplying together all polynomials.", "LDPC code is used to encode the output of the outer BCH encoding.", "To generate a completed Bldpc (FECBLOCK).", "Pldpc (parity bits) is encoded systematically from each lldpe (BCH-cncoded BBF), and appended to lldpc.", "The completed Bldpc (FECBLOCK) are expressed as follow Math figure.", "Bldpc=[IldpcPldpc]=[i0, i1, .", ".", ".", ", i−1, p0, p1, .", ".", ".", ", p]tm [Math Figure 3] The parameters for long FECBLOCK, and short FECBLOCK are given in the above table 28 and 29, respectively.", "The detailed procedure to calculate Nldpc−Kldpc parity bits for long FECBLOCK, is as follows: 1) Initialize the parity bits.", "P0=p1=p2= .", "=pNldpc−Kldpr−1=0 [Math Figure 4] 2) Accumulate the first information bit −10, at parity bit addresses specified in the first row of addresses of parity check matrix.", "The details of addresses of parity check matrix will be described later.", "For example, for rate 13/15: p 983 = p 983 ⊕ i 0   p 4837 = p 4837 ⊕ i 0   p 6138 = p 6138 ⊕ i 0   ?", "= ?", "⊕ i 0   ?", "= ?", "⊕ i 0   p 8496 = p 8496 ⊕ i 0   p 2815 = p 2815 ⊕ i 0   p 4989 = p 4989 ⊕ i 0   p 6458 = p 6458 ⊕ i 0   p 6974 = p 6974 ⊕ i 0   ?", "= ?", "⊕ i 0   ?", " indicates text missing or illegible when filed [ Math   Figure   5 ] 3) For the next 359 information bits, is, s=1, 2, .", ".", ".", ", 359 accumulate is at parity bit addresses using following Math figure.", "{x+(s mod 360)×Qldpc}mod (Nldpc−Kldpc) [Math Figure 6] where x denotes the address of the parity bit accumulator corresponding to the first bit i0, and Qldpc is a code rate dependent constant specified in the addresses of parity check matrix.", "Continuing with the example, Qldpc=24 for rate 13/15, so for information bit i1, the following operations are performed: p 1007 = p 1007 ⊕ i 0   p 1861 = p 1861 ⊕ i 0   p 6162 = p 6162 ⊕ i 0   ?", "= ?", "⊕ i 0   ?", "= ?", "⊕ i 0   ?", "= ?", "⊕ i 0   p 2839 = p 2839 ⊕ i 0   p 5013 = p 5013 ⊕ i 0   ?", "= ?", "⊕ i 0   p 6998 = p 6998 ⊕ i 0   ?", "= ?", "⊕ i 0   ?", " indicates text missing or illegible when filed [ Math   Figure   7 ] 4) for the 361st information bit i360, the addresses of the parity bit accumulators are given in the second row of the addresses of partly check matrix.", "In a similar manner the addresses of the parity bit accumulators for the following 359 information bits is, s=361, 362, .", ".", ".", ", 719 are obtained using the Math figure 6, where x denotes the address of the parity bit accumulator corresponding to the information bit i360, i.e., the entries in the second row of the addresses of parity check matrix.", "5) In a similar manner, for every group of 360 new information bits, a new row from addresses of parity check matrixes used to find the addresses of the parity bit accumulators.", "After all of the information bits are exhausted, the final parity bits are obtained as follows: 6) Sequentially perform the following operations starting with i=1 =pi⊕pi−1, i=1,2, .", ".", ".", ", Nldpc−Kldpc−1 [Math Figure 8] where final content of pi, i=0, 1, .", ".", ".", "Nldpc−Kldpc−1 is equal to the parity bit pi.", "TABLE 30 Code Rate Qldpc 5/15 120 6/15 108 7/15 96 8/15 84 9/15 72 10/15 60 11/15 48 12/15 36 13/15 24 This LDPC encoding procedure for a short FECBLOCk is in accordance with t LDFC encoding procedure for the long FECBLOCK, except replacing the table 30 with table 31, and replacing the addresses of parity check matrix for the long FECBLOCK with the addresses of parity check matrix for the short FECBLOCK.", "TABLE 31 Code Rate Qldpc 5/15 30 6/15 27 7/15 24 8/15 21 9/15 18 10/15 15 11/15 12 12/15 9 13/15 6 FIG.", "23 illustrates a bit interleaving according to an embodiment of the present invention.", "The outputs of the LDPC encoder are bit-interleaved, which consists of partly interleaving followed by Quasi-Cyclic Block (QCB) interleaving and inner-group interleaving.", "(a) shows Quasi-Cyclic Block (QCB) interleaving and (b) shows inner-group interleaving.", "The FECBLOCK may be parity interleaved.", "At the output of the parity interleaving, the LDPC codeword consists of 180 adjacent QC blocks in a long FECBLOCK and 45 adjacent QC blocks in a short FECBLOCK.", "Each QC block in either a long or short FECBLOCK consists of 360 bits.", "The parity interleaved LDPC codeword is interleaved by QCB interleaving.", "The unit of QCB interleaving is a QC block.", "The QC blocks at the output of parity interleaving are permutated by QCB interleaving as illustrated in FIG.", "23, where Ncells=64800/ηmod or 16200/ηmod according to the FECBLOCK length.", "The QCB interleaving pattern is unique to each combination of modulation type and LDPC code rate.", "After QCB interleaving, inner-group interleaving is performed according to modulation type and order (ηmod) which is defined in the below table 32.The number of QC blocks for one inner-group, NQCB_IG, is also defined.", "TABLE 32 Modulation type ηmod NQCB—IG QAM-16 4 2 NUC-16 4 4 NUQ-64 6 3 NUC-64 6 6 NUQ-256 8 4 NUC-256 8 8 NUQ-1024 10 5 NUC-1024 10 10 The inner-group interleaving process is performed wslh NQCB_IG_QC blocks of the QGB interleaving output.", "Inner-group interleaving has a process of writing and reading the bits of the inner-group using 360 columns and NQCB_IG rows.", "In the write operation, the bits from the QCB interleaving output are written row-wise.", "The read operation is performed column-wise to read out m bits from each row, where m is equal to 1 for NUC and 2 for NUQ.", "FIG.", "24 illustrates a cell-word demultiplexing according loan embodiment of the present invention.", "(a) shows a cell-word demultiplexing for 8 and 12 bpcu MIMO and (b) shows a cell-word demultiplexing for 10 bpcu MIMO.", "Each cell word (c0, 1, c1, 1, .", ".", ".", ", cηmod-1,1) of the bit interleaving output is demultiplexed into (d1,0, m.d1, 1,m .", ".", ".", ", d1,ηmod-1,m) and (d2,0,m, d2,1,m .", ".", ".", "d2,ηmod-1,m) as shown in (a), which describes the cell-word demultiplexing process for one XFECBLOCK.", "For the 10 bpcu MIMO case using different types of NUQ for MIMO encoding, the Bit Interleaver for NUQ-1024 is re-used.", "Each cell word (c0,1, c1,1.. .", ", c9,1) of the Bit Interleaver output is demultiplexed into (d1,0,m, d1,1,m .", ".", ".", ", d1,1m) and (d2,0,m, d2,1,m .", ".", ".", ", d2,5,m), as shown in (b).", "FIG.", "25 illustrates a time interleaving according to an embodiment of the present invention.", "(a) to (c) show examples of TI mode.", "The time interleaver operates at the DP level.", "The parameters of time interleaving (TI) may be set differently for each DP.", "The following parameters, which appear in part of the PLS2-STAT data, configure the TI: DP_TI_TYPE (allowed values; 0 or 1): Represents the TI mode; ‘0’ indicates the mode with multiple TI blocks (more than one TI block) per TI group.", "In this case, one TI group is directly mapped to one frame (no inter-frame interleaving).", "‘1’ indicates the mode with only one TI block per TI group.", "In this case, the IT block may be spread over more than one frame (inter-frame interleaving).", "DP_TI_LENGTH: If DP_TI_TYPE=‘0’, this parameter is the number of TI blocks NTI per TI group.", "For DP_TI_TYPE=‘1’, this parameter is the number of frames PI spread from one TI group.", "DP_NUM_BLOCK_MAX (allowed values: 0 to 1023): Represents the maximum number of XFECBLOCKs per IT group.", "DP_FRAME_INTERVAL (allowed values: 1, 2, 4, 8): Represents the number of the frames IJUMP between two successive frames carrying the same DP of a given PHY profile.", "DP_T_BYPASS (allowed values: 0 or 1): If time interleaving is not used for a DP, this parameter k set to ‘1’.", "It is set to ‘0’ if lime interleaving is used.", "Additionally, the parameter DP_NUM_BLOCK from the PLS2-DYN data is used to represent the number of XFECBLOCKs carried by one TI group of the DP.", "When time interleaving is not used for a DP, the following TI group, time interleaving operation, and TI mode are not considered.", "However, the Delay Compensation block for the dynamic configuration information from the scheduler will still be required.", "In each DP, the XFECBLOCKs received from the SSD/MIMO encoding are grouped into TI groups.", "That is, each TI group is a set of an integer number of XFECBLOCKs and will contain a dynamically variable number of XFECBLOCKs.", "The number of XFECBLOCKs in the TI group of index n is denoted by NxBLOCK_Group(n) and is signaled as DP_NUM_BLOCK in the PLS2-DYN data.", "Note that NxBLOCK_Group(n) may vary from the minimum value of 0 to the maximum value NxBLOCK_Group_MAX (corresponding to DP_NUM_BLOCK_MAX) of which the largest value is 1023.Each TI group is either mapped directly onto one frame or spread over PI frames.", "Each TI group is also divided into more than one TI blocks (NTI), where each TI block corresponds to one usage of time interleaver memory.", "The TI blocks within the TI group may contain slightly different numbers of XFECBLOCKs.", "If the TI group is divided into multiple TI blocks, it is directly mapped to only one frame.", "There are three options for rime interleaving (except the extra option of skipping the lime interleaving) as shown in the below table 33.TABLE 33 Modes Descriptions Option-1 Each TI group contains one TI block and is mapped directly to one frame as shown in (a).", "This option is signaled in the PLS2-STAT by DP_TI_TYPE = ‘0’ and DP_TI_LENGTH = ‘1’(NTI = 1).", "Option-2 Each TI group contains one TI block and is mapped to more than one frame.", "(b) shows an example, where one TI group is mapped to two frames, i.e., DP_TI_LENGTH = ‘2’ (PI = 2) and DP_FRAME_INTERVAL (IJUMP = 2).", "This provides greater time diversity for low data-rate services.", "This option is signaled in the PLS2-STAT by DP_TI_TYPE = ‘1’.", "Option-3 Each TI group is divided into multiple TI blocks and is mapped directly to one frame as shown in (c).", "Each TI block may use full TI memory, so as to provide the maximum bit-rate for a DP.", "This option is signaled in the PLS2-STAT signaling by DP_TI_TYPE = ‘0’ and DP_TI_LENGTH = NTI, while PI = 1.In each DP, the TI memory stores the input XFECBLOCKs (output XFECBLOCKs from the SSD/MIMO encoding block).", "Assume that input XFECBLOCKs are defined as ( d n , s , 0 , 0 , d n , s , 0 , 1 , …  , d n , s , 0 , N cells - 1 , d n , s , 1 , 0 , …  , d n , s , 1 , N cells - 1 , …   ?", ", …  , ? )", ",   ?", " indicates text missing or illegible when filed where is the qth cell of the rth XFECBLOCK in the sth TI block of the nth TI group and represents the outputs of SSD and MIMO encodings as follows.", "?", "= { ?", "the   output   of   SSD   …   encoding ?", ", the   output   of   MIMO   encoding   ?", " indicates text missing or illegible when filed In addition, assume that output XFECBLOCKs from the time inter leaver are defined as ( h n , s , 0 , h n , s , 1 , …  , h n , s , i , …  , ? )", ",  ?", " indicates text missing or illegible when filed where is the ith output cell (for i=1, .", ".", ".", ", (n,s)×−1) in the sth TI block of the nth TI group.", "Typically, the lime Interleaver will also act as a buffer for DP data prior to the process of frame building.", "This is achieved by means of two memory banks for each DP.", "The first TI-block is written to the first bank.", "The second TI-block is written to the second bank white the first bank is being read from and so on.", "The TI is a twisted row-column block interleaver.", "For the sth TI block of the nth TI group, the number of rows Nr of a TI memory is equal to the number of cells i.e., =Ncells while the number of columns is equal to the number (n,s).", "FIG.", "26 illustrates the basic operation of a twisted row-column block interleaver according to an embodiment of the present invention.", "shows a writing operation in the time inlerieaver and (b) shows a reading operation in the time interleaver The first XFECBLOCK is written column-wise into the first column of the TI memory, and the second XFECBLOCK is written into the next column, and so on as shown in (a).", "Then, in the interleaving array, cells are read out diagonal-wise.", "During diagonal-wise reading from the first row (rightwards along the row beginning with the left-most column) to the last row.", "Nr cells are read out as shown in (b).", "In detail, assuming Z(i=0, .", ".", ".", ", NrN) as the TI memory cell position to be read sequentially, the reading process in such an interleaving array is performed by calculating the row index the column index Cand the associated twisting parameter as follows expression.", "GENERATE   {  R n , s , i = mod  ( i , N r ) ,  T n , s , i = mod  ( S shift × R n , s , i , N c ) ,  C n , s , i = mod  ( T n , s , i + ⌊ i N r ⌋ , N c )  } [ Math   Figure   9 ] where is a common shift value for the diagonal-wise reading process regardless of (n,s), and it ts determined by given in lite PLS2-STAT as follows expression.", "for  { N xBLOCK  _  TI  _  MAX ′ = N xBLOCK  _  TI  _  MAX + 1 , if   N xBLOCK  _  TI  _  MAX  mod   2 = 0 N xBLOCK  _  TI  _  MAX ′ = N xBLOCK  _  TI  _  MAX ′ , if   N xBLOCK  _  TI  _  MAX  mod   2 = 1 ,    S shift = N xBLOCK  _  TI  _  MAX - 1 2 [ Math   Figure   10 ] As a result, the cell positions to be read are calculated by a coordinate as .", "FIG.", "27 illustraies an operation of a twisted row-column block interleaver according to another embodiment of the present invention.", "More specifically.", "FIG.", "27 illustrates the interleaving array in the TI memory for each TI group, including virtual XFFCBLOCKs when=3, (1,0)=6, (2,0)=5.The variable number (n,s)=N, will be less than or equal to NBLOCK_n_MAX.", "Thus, in order to achieve a single-memory deinterleaving at the receiver side, regardless of NBLOCK_n interleaving array for use in a twisted row-column block interleaver is set to the size of ×NBLOCK_TI_MAX by inserting the virtual XFECBLOCKs into the TI memory and the reading process is accomplished as follow expression.", "[Math FIG.", "11] p = 0; for i = 0;i < NcellsNxBLOCK—TI—MAX′;i = i + 1 {GENERATE (Rn,s,i,Cn,s,i); Vi = NrCn,s,j + Rn,s,j if Vi < NcellsNxBLOCK—TI(n,s) { Zn,s,p = Vi; p = p + 1; } } The number of TI groups is set to 3.The option of time interleaver is signaled in the PLS2-STAT data by DP_TYPE=‘0’, DP_FRAME_INTERVAL=‘1’, and DP_TI_LENGTH=‘1’, i.e., NTI=1, IJUMP=1, and PI=1.The number of XFECBLOCKs, each of which has Ncells=30 cells, per TI group is signaled in the PLS2-DYN data by NxBLOCK_TI(0,0)=3.NxBLOCK_TI(1,0)=6, and NxBLOCK_TI(2,0), respectively.", "The maximum number of XFECBLOCK is signaled in the PLS2-STAT data by NxBLOCK_Group_MAX, which leads to └NBLOCK/N┘=NBLOCK=6.FIG.", "28 illustrates a diagonal-wise reading pattern of a twisted row-column block interleaver according to an embodiment of the present invention.", "More specifically FIG.", "28 shows a diagonal-wise reading pattern from each interleaving array with parameters of NBLOCK_TI_MAX=7 and Sshift=(7−1)/2=3.Note that in the reading process shown as pseudocode above, if Vi≥NNBLOCK (n,s), the value of Vi is skipped and the next calculated value of Vi is used.", "FIG.", "29 illustrates interleaved XFECBLOCKs from each interleaving array according to an embodiment of the present invention.", "FIG.", "29 illustrates the interleaved XFECBLOCKs from each interleaving array with parameters of NBLOCK_TI_MAX=7 and Sshift=3.FIG.", "30 is a conceptual diagram illustrating a protocol stack for the next generation broadcast system based on hybrid according to an embodiment of the present invention.", "The present invention proposes a data link (encapsulation) part shown in FIG.", "30, and proposes a method for transmitting MPEG-2 TS (Transport Stream) and/or IP (Internet Protocol) packets received from an upper layer over a physical layer.", "In addition, the present invention provides a signaling transmission method needed to operate a physical layer.", "In addition, when transmission of a new packet type is considered in an upper layer in the future, the present invention can implement a method for transmitting the new packet transmission information to a physical layer.", "The corresponding protocol layer may also be referred to as a data link layer, an encapsulation layer, a Layer 2, or the like.", "For convenience of description and better understanding of the present invention, the protocol layer will hereinafter be referred to as a link layer.", "When the term “protocol layer” is actually applied to the present invention, it should be noted that the term “protocol layer” may be replaced with the term ‘link layer’ or may also be called a new name as necessary.", "The broadcast system according to the present invention may correspond to a hybrid broadcast signal implemented by combination of an IP (internet Protocol) centric broadcast network and a broadband network.", "The broadcast system according to the present invention may be designed to be compatible with the legacy MPEG-2 based broadcast system.", "The broadcast system according to the present invention may correspond to a hybrid broadcast system based on a combination of the IP centric broadcast network, a broadband network, and/or a mobile communication network or cellular network.", "Referring to FIG.", "30, a physical layer may use a physical protocol adopted by a broadcast system such as the ATSC and;or DVB system.", "In an encapsulation layer, an IP datagram may be obtained from specific information acquired from a physical layer, or the obtained IP datagram may be converted into a specific frame (e.g., RS frame, GSE-lite, GSE or signal frame).", "In this case, the frame may include an aggregate of IP datagrams.", "A fast access channel (FAC) may include specific information (e.g., mapping information between a service ID and a frame) used for access to a service and/or contents.", "A broadcast system according to the present invention may use a variety of protocols, for example, Internet Protocol (IP), User Datagram Protocol (UDP), Transmission Control Protocol (TCP), ALC/LCT (Asynchronous Layered Coding/Layered Coding Transport), RCP/RTCP (Rate Control Protocol/RTP Control Protocol), HTTP (Hypertext Transfer Protocol), FLUTE (File Delivery over Unidirectional Transport), etc.", "A stack between protocols may refer to the structure of FIG.", "30.In the broadcast system of the present invention, data may be transmitted in the form of ISOBMFF (ISO base media tile format).", "ESQ (Electrical Service Guide), NRT (Non Real Time), A/V (Audio/Video) and/or general data may be transmitted in the form of ISOBMFF.", "Data transmission caused by the broadcast network may include linear content transmission and/or non-linear content transmission.", "RTP/RTCP based A/V, and data (closed caption, emergency alert message, etc.)", "transmission may correspond to linear content transmission.", "RTP payload may be encapsulated and transmitted in the form of an RTP/AV stream including a Network Abstraction Layer (NAL) and/or in the form of an ISO based media file format.", "RTP payload transmission may correspond to linear content transmission.", "If the RTP payload is encapsulated and transmitted in the form of an ISO based media file format, the RTP payload may include MPEG DASH media segments for A/V or the like.", "FLUTE based ESG transmission, non-timed data transmission, and NRT content transmission may correspond to non-linear content transmission.", "The above-mentioned information may be encapsulated and transmitted in the form of a MIME type file and/or an ISO based media file format.", "If data is encapsulated and transmitted in the form of an ISO based media file format, this data transmission may conceptually include an MPEG DASH media segment for A/V or the like.", "Data transmission over the broadband network may be classified into transmission of contents and transmission of the signaling data.", "Content transmission may include transmission of linear content (A/V, data(closed caption, emergency alert messages, etc.", "), transmission of non-linear content (ESG, non-timed data, etc.", "), and transmission of an MPEG DASH based Media segment (A/V, data).", "Transmission of the signaling data may include transmission of data including a signaling table (including MPD of MPEG DASH) transmitted on the broadcast network.", "The broadcast system of the present invention may support not only synchronization between lincar/non-linear contents having been transmitted over the broadcast network, but also synchronization between content transmitted over the broadcast network and content transmitted over the broadband network.", "For example, if one UD content is divided into the broadcast network and the broadband network and then simultaneously transmitted over the broadcast and broadband networks, the receiver may coordinate a timeline dependent upon a iransmission (Tx) protocol, may synchronize contents of the broadcast network and the broadband contents, and may reconstruct the synchronized contents into one piece of UE content.", "An application layer of the broadcast system may implement technical characteristics, for example, interactivity, personalization, second screen.", "ACR (automatic content recognition), etc.", "The above-mentioned technical characteristics are of importance to the North American broadcast standard evolved from ATSC 2.0 to ATSC 3.0.For example.", "HTML5 may be used to implement interactivity.", "In a presentation lajer of the broadcast system of the presenl invention, HTML and/or HTML may be used to identity the space and time relationship between components or between bidirectional applications.", "The broadcast system according to another embodiment may be implemented by addition or modification of the above-mentioned broadcast system, and a detailed description of the individual constituent elements will be replaced with that of the above-mentioned broadcast system.", "The broadcast system according to another embodiment of the present invention may include a system structure compatible with the MPEG-2 system.", "For example, the linear/non-linear contents transmitted in the legacy MPEG-2 system can be received or operated in the ATSC 3.0 system, and the A/V and data processing may be adaptively coordinated according to whether data received by the ATSC 3.0 system is an MPEG-2 TS or IP datagram.", "In an encapsulation layer of the broadcast system according to another embodiment of the presenl invention, information/data obtained from a physical layer may be converted into the MPEG-2 TS or IP datagram, or may be converted into a specific frame (e.g., RS frame.", "GSH-lite, GSE or signal frame, etc.)", "using the IP datagram.", "The broadcast system according to another embodiment may include signaling information capable of being adaptively obtained according to whether MPEG-2 TS or IP datagram is used to acquire the service/content through the broadcast network.", "That is, when obtaining signaling information from the broadcast system, the signaling information may be obtained on the basis of MPEG-2 TS, or may be obtained from data based on a UDP protocol.", "The broadcast system of the present invention may support synchronization between the linear/mon-linear contents based on the broadcast network encapsulated by MPEG-2 TS and/or IP datagram.", "Alternatively, the broadcast system can support synchronization between content fragments that are respectively transmitted through the broadcast network and the broadband network.", "For example, if one UD content is divided into the broadcast network and the broadband network and then simultaneously transmitted over the broadcast and broadband networks, the receiver may coordinate a timeline dependent upon a transmission (Tx) protocol, may synchronize contents of the broadcast network and the broadband contents, and may reconstruct the synchronized contents into one piece of UE content.", "FIG.", "31 is a conceptual diagram illustrating an interface of a link layer according to an embodiment of the present invention.", "Referring to FIG.", "31, the transmitter may consider an exemplary case in which IP packets and/or MPEG-2 TS packets mainly used in the digital broadcasting are used as input signals.", "The transmitter may also support a packet structure of a new protocol capable of being used in the next generation broadcast system.", "The encapsulated data of the link layer and signaling information may be transmitted io a physical layer.", "The transmitter may process the transmitted data (including signaling data) according to ihc protocol of a physical layer supported by the broadcast system, such that the transmitter may transmit a signal including the corresponding data.", "On the other hand, the receiver may recover data and signaling information received from the physical layer into other data capable of being processed in a higher layer.", "The receiver may read a header of the packet, and may determine whether a packet received from the physical layer indicates signaling information (or signaling data) or recognition data (or content data).", "The signaling information (i.e., signaling data) received from the link layer of the transmitter may include first signaling information that is received from an upper layer and needs to be transmitted to an upper layer of the receiver; second signaling information that is generated from the link layer and provides information regarding data processing in the link layer of the receiver: and/or third signaling information that is generated from the upper layer or the link layer and is transferred to quickly detect specific data (e.g., service content, and/or signaling data) in a physical layer.", "FIG.", "32 is a conceptual diagram illustrating a packet structure of a link elayer according to an embodiment of the present invention.", "In accordance with an embodiment of the present invention, the packet of the link layer may include a fixed header, an extended header, and/or payload.", "A fixed header is designed to have a fixed size.", "For example, the fixed header may be 1 byte long.", "The extended header can be changed in size.", "Payload including data received from the higher layer may be located behind the fixed header and the extended header.", "The fixed header may include a packet type element and/or an indicator part element.", "The packet type element may be 3 bits long.", "The packet type element may identify a packet type of a higher layer (i.e., a higher layer of the link layer).", "The packet type identified by the packet type element value will hereinafter be described in detail.", "The indicator part element may include information regarding a payload construction method and/or construction information of the extended header.", "The construction method and/or the construction information indicated by the indicator part element may be changed according to packet types.", "FIG.", "33 shows packet types dependent upon the packet type element values according to an embodiment of the present invention.", "Referring to FIG.", "33, if the packet type element is set to ‘000’, this means that a packet transferred from the higher layer to the link layer is an IPv4 (Internet Protocol version 4) packet.", "If the packet type element value is set to ‘001’, this means that a packet transferred from the higher layer to the link layer is an IPv6 (Internet Protocol version 6) packet.", "If the packet type element value is set to ‘010’, this means that a packet transferred from the higher layer to the link layer is a Compressed IP packet.", "If the packet type element value is set to ‘011’, this means that a packet transferred from the higher layer to the link layer is an MPEG-2 TS packet.", "If the packet type element value is set to ‘101’, this means that a packet transferred from the higher layer to the link layer is a Packetized Stream packet.", "For example, the Packetized Stream may correspond to an MPEG media transport packet.", "If the packet type element value is set to ‘110’, this means that a packet transferred from the higher layer to the link layer is a packet for transmitting signaling information (signaling data).", "If the packet type element value is set to ‘111’, this means that a packet transferred from the higher layer to the link layer is a Framed Packet type.", "FIG.", "34 if a conceptual diagram illustrating a header structure of a link layer packet when an IP packet is transmitted to the link layer according to an embodiment of the present invention.", "Referring to FIG.", "34, if the IP packet is input to the link layer, the packet type element value may be 000B (3 bits of 000) or 001B (3 bits of 001).", "Referring to a packet header of the link layer when an IP packet is input, the indicator part element located next to the packet type element may include a C/S (Concatenation/Segmentation) field and/or an additional bit of 3 bits (hereinafter referred to as an additional field).", "In case of the packet of the link layer, an additional field of the fixed header and information of the extended header may be decided according to the CS (Concatenation/Segmentation) field of 2 bits located behind the packet type element.", "The C/S field indicates the processing type of the input IP packet, and may include information regarding the extended header length.", "In accordance with an embodiment of the present invention, the case in which the C/S field is set to 00B (2 bits of 00) may indicate that payload of the link layer packet includes a normal packet.", "The normal packet may indicate that the input IP packet is used as payload of the link layer packet without change.", "In this case, the additional field of the fixed header part is not in use, and may be reserved for a subsequent use.", "In this case, the extended header may not be used.", "If the C/S field is set to ‘01B’ (2 bits of ‘01’), this means that payload of the link layer packet includes a concatenated packet.", "The concatenated packet includes one or more IP packets.", "That is, one or more IP packets may be contained in payload of the link layer packet.", "In this case, the extended header is not used, and the additional field located subsequent to the C/S field may be used as the count field.", "A detailed description of the count field will hereinafter be described in detail.", "If the C/S field is set to ‘10B’ (2 bits of ‘10’), this means that payload is composed of segmented packets.", "The segmented packet is obtained by dividing one IP packet into a few segments.", "Specifically, the segmented packet may include one segment from among the divided segments.", "That is, payload of the link layer packet may include any one of a plurality of packets contained in the IP packet.", "The additional field located behind the C/S field is used as the segment ID.", "The segment ID may uniquely identify the segment.", "The segment ID is assigned when the IP packet is segmented.", "In more detail, if segments to be respectively transmitted in the fulure are integrated, the segment ID can indicate the presence of a constituent element of the same IP packet.", "The segment ID may be 3 bits long, and at the same time can support segmentation of the IP packe.", "For example, the divided segments obtained by one IP packet may have the same segment ID.", "In this case, the extended header may be 1 byte long.", "In this case, the extended header may include the Seg_SN (Segment Sequence Number) field and/or the Seg_Len_ID (Segment length ID) field.", "The Seg_SN field may be 4 bits long, and may indicate a sequence number of the corresponding segment for use in the IP packet.", "When the Seg_SN field IP packet is segmented, the Seg_SN field may be used to confirm the order or sequence of each segment.", "Accordingly, although the link layer packets including a payload segmented from one IP packet may have the same segment ID (Seg_ID), the link layer packets may have different Seg_SN field values.", "The Seg_SN field may be 4 bits long.", "In this case, one IP packet can be segmented into a maximum of 16 segments.", "If a user desires to divide the IP packet into many more segments, the Seg_SN field is increased in size so that the Seg_SN field may indicate each order of the segment and/or the number of segments.", "The Seg_Len_ID (Segment Length ID) field may be 4 bits long, and may be used to identify the segment length.", "The actual segment length according to the Seg_Len_ID field value may be identified by a table to be described later.", "If the length value of an actual segment is signaled instead of the Seg_Len_ID field, the Seg_Len_ID field of 4 bits may be extended to the segment length field of 12 bits.", "In this case, the extended header of 2 bytes may be contained in the link layer packet.", "If the C/S field value is set to 11B (2 bits of ‘11’), this means an exemplary case in which payload includes the segmented packet as in the case in which the C/S field value is set to 10B, However, the C/S field of 11B may also indicate that the last segment from among several segments divided in one IP packet may be contained in a payload.", "When segments are collected to reconstruct one IP packet, the receiver may identify the link layer packet configured to transmit the last segment using the C/S field value, and the segment contained in the payload of the corresponding packet may be recognized as the last segment.", "The additional field located behind the C/S field may be used as the segment ID.", "In this case, the extended header may be 2 bytes long.", "The extended header may include the Seg_SN (Segment Sequence Number) field and/or the L_Seg_Len (Last Segment Length) field.", "The L_Seg_Len field may indicate the actual length of the last segment.", "If data is segmented to generate the same-sized data segments in the order from the front part of the IP packet using the Seg_Len_ID field, the last segment may have a different size as compared to another previous segment.", "Accordingly, the segment length may be directly indicated using the L_Seg_Len field.", "The segment length may be changed according to the number of allocated bits of the L_Seg_Len field.", "However, when allocating the number of bits according to the present invention, the L_Seg_Len field may indicate that the last segment is 1-4095 bytes long.", "That is, if one IP packet is divided into a plurality of segments, the IP packet can be divided into a plurality of segments having a predetermined length.", "However, the length of the last segment may be changed according to the length of the IP packet.", "Accordingly, the length of the last segmenl needs to be signaled independently.", "A detailed description of the field having the same name may be replaced with the above-mentioned description.", "FIG.", "35 is a conceptual diagram illustrating the meaning and header structures according to C/S field values.", "Referring to FIG.", "35, if the C/S field is set to ‘00’ this means that a normal packet is contained in the paylnad of the link layer packet and the additional field is reserved.", "On the other hand, the extended header may not be contained in the link layer packet.", "In this case, a total length of the header of the link layer packet may be 1 byte.", "If the C/S field is set to ‘01’, a concatenated packet is contained in the payload of the link layer packet and the additional field may be used as the count field.", "A detailed description of the count field will be given later.", "In the meantime, the extended header may not be contained in the link layer packet.", "In this case, a total length of the header of the link layer packet may be 1 byte.", "If the C/S field is set to ‘10’, the segmented packet may be contained in the payload of the link layer packet, and the additional field may be used as the segment ID.", "In the meantime, the extended header may be contained in the link layer packet, and the extended header may include the Seg_SN field and/or the Seg_Len_ID field.", "A detailed description of the Seg_SN field or the Seg_Len_ID field may be replaced with the above-mentioned description or a description to be given later.", "A total length of the link layer packet may be 2 bytes.", "If the C/S field is set to ‘11’, the segmented packet (i.e., packet including the last segment) may be contained in the payload of the link layer packet, and the additional field may be used as the segment ID.", "Meanwhile, the extended header may be contained in the link layer packet, and the extended header may include the Seg_SN field and/or the L_Seg_Len field.", "A detailed description of the Seg_SN field or the L_Seg_Len field may be replaced with the above-mentioned description or a description to be described given.", "A total length of the link layer packet may be 3 bytes.", "FIG.", "36 is a conceptual diagram illustrating the meaning according to the count field values.", "Referring to FIG.", "36, the count field may be used in the case in which the payload of the link layer packet includes a concatenated packet.", "The count field may indicate how many IP packets are contained in one payload.", "The value of the count field may indicate the number of concatenated IP packets.", "However, zero or one concatenation has no meaning, such that the count field may indicate that the IP packets, the number of which is denoted by “count field value+2”, are contained in the payload.", "In accordance with one embodiment, 3 bits may be allocated to the count field, so that this means that a maximum of 9 IP packets has been contained in the payload of the link layer packet.", "If there is a need to include many more IP packets in one payload, the length of the count field may be extended, or 9 or more IP packets of the extended header may be additionally signaled.", "FIG.", "37 is a conceptual diagram illustrating the meaning and segment lengths according to values of Seg_Len_ID field.", "Referring to FIG.", "37, the Seg_Len_ID field may be used to indicate the length of segments other than the last segment from among several segments.", "In order to reduce overhead of the header needed for indicating the segment length, an available segment size may be limited to 16 segments.", "The segment length is decided in response to the packet input size predetermined by a code rate of Forward Error Correction (FEC) processed by a physical layer, and the decided segment length may be designated as a length for each value of the Seg_Len_ID field.", "For example, in association with each value assigned to the Seg_Len_ID field, the segment length may be predetermined.", "In this case, information regarding the segment length dependent upon each value of the Seg_Len_ID field is generated by the transmitter and transmitted to the receiver, such that the receiver may store the received information therein.", "In the meantime, the segment length established to have each value of the Seg_Len_ID field may be changed.", "In this case, the transmitter may generate new information and transmit the new information to the receiver, and the receiver may update stored information on the basis of the above new information.", "In the meantime, if the physical layer processing is performed irrespective of the segment length, the segment length may be calculated as shown in the equation of FIG.", "37.In Equation of FIG.", "37, Len_Unit (Length Unit) may be a basic unit for indicating the segment length, and min_Len may be a minimum value of the segment length.", "Len_Unit and min_Len may be set to the same value not only in the transmitter but also in the receiver.", "After the above-mentioned parameters of Equation have been decided once, it is preferable that the above parameters remain unchanged in terms of system throughput.", "This value may be decided in consideration of the FEC processing throughput of the physical layer during an initiation process of the system.", "For example, as shown in FIG.", "37, the Len_Unit or min_Len value may indicate the segment length differently represented in response to the Seg_Len_ID field value.", "At this time, the parameter ‘Len_Unit’ may be 256, and the parameter ‘min_Len’ may be 512.FIG.", "38 is a conceptual diagram illustrating an equation for encapsulating a normal packet and an equation for calculating a link layer packet length.", "Referring to FIG.", "38, if the input IP packet is not concatenated or segmented within the processing range of the physical layer as described above, the IP packet may be encapsulated into a normal packet.", "The following contents may be equally applied to IPv4 and IPv6 IP packets.", "One IP packet may be used as payload of the (ink layer packet without change, the packet type element value may be set to 000B (IPv4) or 001B (IPv6), and the C/S field value may be set to 00B (Normal Packet).", "The remaining three bits of the fixed header may be set to a reserved field to be used for another usage in future.", "The link layer packet length can be identified as follows.", "A specific field indicating the IP packet length may be contained in the header of the IP packet.", "The field indicating the length is always located at the same position, such that the receiver may confirm the field located at a specific position spaced apart from an initial part (start part) of the link layer packet by a predetermined offset, such that the payload length of the link layer packet can be recognized.", "The receiver can read the length field having the length of 2 bytes at a specific position spaced apart from the start point of the payload by 2 bytes in case of IPv4, and can read the length field having the length of 2 bytes at a specific position spaced apart from the start point of the payload by 4 bytes tn case of IPv6.Referring to FIG.", "38, assuming that the IPv4 length field is set to LIPv4, LIPv4 indicates a total length of IPv4.In this case, if the header length LH (1 byte) of the link layer packet is added to LIPv4.the length of the entire link layer packet is obtained.", "In this case, LT may indicate the length of the link layer packet.", "Referring to the equation of FIG.", "38, assuming that the IPv6 length field is denoted by LIPv6.LIPv6 indicates only the payload length of the IPv6 IP packet.", "Accordingly, if the header length LH (1 byte) of the link layer packet is added and the fixed header length (40 bytes) of IPv6 is additionally added, the length of the link layer packet is obtained.", "Here, LT may denote the length of the link layer packet.", "FIG.", "39 is a conceptual diagram illustrating a process for encapsulating a concatenated packet and an equation for calculating a link layer packet length.", "Referring to FIG.", "39, if the Input IP packet does not arrive within the processing range of the physical layer, some IP packets are concatenated and encapsulated into one link layer packet.", "The following description can also be applied to IP packets of IPv4 and IPv6.Some IP packets may be used as the payfoad of the link layer packet, the packet type element value may be set to 000B (IPv4) or 001D (IPv6), and the C/S field may be set to 01B (Concatenated Packet).", "In addition, the count field of 3 bits indicating how many IP packets are contained in one payload may be concatenated to the C/S field of 01B.", "In order to calculate the length of the concatenated packet by the receiver, a similar way to the normal packet case may be used.", "Assuming that the number of concatenated IP packets indicated by the count field is denoted by n, the header length of the link layer packet is denoted by LH, and the length of each IP packet is denoted by Lk (where 1≤k≤n), the entire link layer packet length (LT) can be calculated as shown in the equation.", "Since the concatenated packet has the fixed header information only, LH=1 (byte) is achieved, and each Lk (where 1≤k≤n) value can be confirmed by reading the value of the length field contained in the header of each IP packet contained in the concatenated packet.", "The receiver may parse the length field of a first IP packet at a specific position that has a predetermined offset on the basis of a payload start position after the link layer packet header has ended, and may identify the length of a first IP packet using this length field.", "The receiver may parse the length field of a second IP packet at a specific position that has a predetermined offset on the basis of a length end point of the first IP packet, and may identify the length of the second IP packet using this length field.", "The above-mentioned operation is repeated a predetermined number of times corresponding to the number of IP packets contained in the payload of the link layer packet, so that the paylaod length of the link layer packet can be identified.", "FIG.", "40 is a conceptual diagram illustrating a process for calculating the length of a concatenated packet, including an IPv4 packet and an equation for calculating an offset value at which a length field of the IP packet is located.", "When the IP packet is input to the transmitter, the transmitter has no difficulty in reading the length field of the IP packet.", "However, the receiver can recognize only the number of IP packets constructing the link layer packet through the header, such that the position of each length field is not well known in the art.", "However, since the length field is always located at the same position of the header of the IP packet, the position of the length field is detected using the following method, so that the length of each IP packet contained in the payload of the concatenated packet can be calculated and recognized.", "Assuming that n IP packets contained in the payload of the concatenated packet are respectively denoted by IP1, IP2, .", ".", ".", ", IPk, .", ".", ".", ", IPn, the position of the length field corresponding to IPk may be spaced apart from a start point of the payload of the concatenated packet by Pk bytes.", "In this case, Pk (where 1≤k≤n) may be an offset value at which the length field of the k-th IP packet is located on the basis of a start point of the payload of the concatenated packet, and the Pk value can be calculated as shown in the equation of FIG.", "40.In this case, PI of the IPv4 packet is 2 bytes, Therefore, the Pk value is successively updated from PI, and the Lk value corresponding to the Pk value is read.", "If Lk is applied to the equation of FIG.", "39, the length of concatenated packet can be finally calculated.", "FIG.", "41 is a conceptual diagram illustrating a process for calculating the length of a concatenated packet including an IPv6 packet and an equation for calculating an offset value at which a length field of the IP packet is located If the IPv6 packets are concatenated and contained in the payload of the link layer packet, a method for calculating the payload length is as follows.", "The length field contained in the IPv6 packet indicates information regarding the payload length of the IPv6 packet, and 40 bytes indicating the length of a tixed header of IPv6 are added to the payload length of the IPv6 packet indicated by the length field, such that the length of IPv6 packet can be calculated.", "Assuming that n IP packets contained in the payload of the concatenated packet are respectively denoted by IP1, IP2, .", ".", ".", ", IPk, .", ".", ".", ", IPn, the position of the length field corresponding to IPk may be spaced apart from the start position of the payload of the concatenated packet by Pk bytes.", "In this case, Pk (wherein 1≤k≤n) may be an offset value at which the length field of the k-th IP packet is located on the basis of a start point of the payload of the concatenated packet, and may be calculated by the equation shown in FIG.", "41.In this case, PI in case of IPv6 has 4 bytes.", "Accordingly, the Pk value is successively updated from PI, and Lk corresponding to the Pk value is read.", "If this Lk value is applied to the equation of FIG.", "39, the length of concatenated packet can be finally calculated.", "FIG.", "42 is a conceptual diagram illustrating an encapsulation process of a segmented packet according to an embodiment of the present invention.", "The following description can be equally be applied to the IPv4 IP packet and the IPv6 IP packet.", "One IP packet is segmented to result in a payload of several link layer packets.", "The packet type element value may be set to 000B (IPv4) or 001B (IPv6), and the C/S field value may be 10B or 11B according to the segment construction.", "The C/S field may be set to 11B only in a specific segment corresponding to the last part of the IP packet, and may be set to 10B in the remaining segments other than the above specific segment.", "The C/S field value may also indicate information of the extended header of the link layer packet as described above.", "That is, if the C/S field is set to 10B, the header is 2 bytes long.", "If the C/S field is set to 11B, the header is 3 bytes long.", "In order to indicate the segmentation state from the same IP packet, the Seg_ID (segment ID) values contained in the headers of the individual link layer packets must have the same value.", "In order to allow the receiver to indicate the order (sequence) information of segments for recombination of normal IP packets, the sequentially increasing Seg_SN values are recorded in the header of each link layer packet.", "When the IP packet is segmented, the segment length is decided as described above, and the segmentation process based on the same length is carried out.", "Thereafter, the Seg_Len_ID value appropriate for the corresponding length information is recorded in the header.", "In this case, the length of the last segment may be changed as compared to the previous segment, so that the length information may be directly designated using the L_Seg_Len field.", "The length information designated by the Seg_Ln_ID field and the L_Seg_Len field may indicate only payload information of the segment (i.e., link layer packet), such that the receiver may identify the length information of the entire link layer packet by adding the header length of the link layer packet to the payload length of the link layer packet using the C/S field.", "FIG.", "43 is a conceptual diagram illustrating a segmentation process of an IP packet and header information of a link layer packet according to an embodiment of the present invention.", "When the IP packet is segmented and encapsulated into the link layer packet, the field values allocated to the header of respective link layer packets are shown in FIG.", "14.For example, if the IP packet having the length of 5500 bytes in the IP layer is input to the link layer, this IP packet is divided into 5 segments (S1, S2, S3, S4, S5), and headers (H1, H2, H3, H4, H5) are added to the 5 segments, so that the added results are encapsulated into the individual link layer packets.", "Assuming that the case of using the IPv4 packet is used, the packet type element value may be set to 000B.", "The C/S field value is set to 10B in the range of H1-H4, and the C/S field value of H5 ts set to 11B.", "All the segment IDs (Seg_IDs) indicating the same IP packet structure may be set to 000B, and the Seg_SN field is sequentially denoted by 0000B-0100B in the range of H1-H5.The resultant value obtained when 5500 bytes is divided by 5 is 1100 bytes.", "Assuming that the segment is composed of the length of 1024 bytes located closest to the 1100 bytes, the length of the last segment S5 is denoted by 1404 bytes (010101111100B).", "In this case, the Seg_Len_ID field may be set to 0010B as shown in the above-mentioned example.", "FIG.", "44 is a conceptual diagram illustrating a segmentation process of an IP packet including a cyclic redundancy check (CRC) according to an embodiment of the present invention.", "When the IP packet is segmented and transmitted to the receiver, the transmitter may attach the CRC to the rear of the IP packet in such a manner that integrity of combined packets can be confirmed by the receiver, and finally the segmentation process may be carried out.", "Generally, since CRS is added to the last part of the packet the CRS is contained in the last segment after completion of the segmentation process.", "When the receiver receives data having a length exceeding the length of the last segment, the received data may be recognized as CRC.", "Alternatively, the length including the CRC length may be signaled as the length of the last segment.", "FIG.", "45 is a conceptual diagram illustrating a header structure of a link layer packet when MPEG-2 TS (Transport Stream) is input to a link layer according to an embodiment of the present invention.", "The packet type element may identify that the MPEG-2 TS packet is input to the link layer.", "For example, the packet type element value may be set to 011B.", "If the MPEG-2 TS ts input, the header structure of the link layer packet is shown in FIG.", "16.If the MPEG-2 TS packet is input to the link layer the header of the link layer packet may include the packet type element, the count field, the PI (PID Indicator) field, and/or the DI (Deleted Null Packet Indicator) field.", "For example, the 2-bit or 3-bit count field, the 1-bit PI (PID Indicator) field, and the 1-bit DI (Deleted Null Packet Indicator) field may be arranged subsequent to the packet type of the header of the link layer packet.", "If the count field has 2 bits, the remaining 1 bit may be used as a reserved field to be used for a subsequent use in future.", "The fixed header part may be constructed in various ways as shown in FIGS.", "16(a) to 16(d) according to locations of the reserved field.", "Although the present invention will be disclosed on the basis of the header of (a) for convenience of description and beuer understanding of the present invention, the same description may also be applied to other types of headers.", "If the MPEG-2 TS packet is input to the link layer (packet type=011), the extended header may not be used.", "The count field may indicate how many MPEG-2 TS packets are contained in the payload of the link layer packet.", "The size of one MPEG-2 TS packet is greatly less than the size of LDPC (Low-density parity-check) input indicating the FEC scheme having a high-selection possibility in the physical layer of the next generation broadcast system, and concatenation of the link layer can be basically considered.", "That is, one or more MPEG-2 TS packets may be contained in the payload of the link layer packet.", "However, the number of concatenated MPEG-2 TS packets is limited to some numbers, so that this information may be identified by 2 bits or 3 bits.", "Since the length of the MPEG-2 T packet is fixed to a predetermined size (e.g., 188 bytes), the receiver may also estimate the payload size of the link layer packet using the count field.", "An example of indicating the number of MPEG-2 TS packets according to the count field will hereinafter be described in detail.", "PI (Common PID indicator) field is set to T when the MPEG-2 TS packets contained in the payload of one link layer packet liave the same PIDs (Packet Identifiers).", "On the contrary, if the MPEG-2 TS packets contained in the payload of one link layer packet have different PIDs the PI field is set to ‘0’.", "The PID field may be 1 bit long.", "DI (Null Packet Deletion Indicator) field is set to 1 when a null packet contained in the MPEG-2 TS packet and then transmitted is deleted.", "If the null packet is not deleted, the DI field is set to ‘0’.", "The DI field may be 1 bit long.", "If the DI field is set to 1, the receiver may reuse some fields of the MPEG-2 TS packet so as to support null packet deletion in the link layer.", "FIG.", "16 shows the number of MPEG-2 TS packets contained in a payload of the link layer packet according to values of a count field.", "If the count field is 2 bits long, the concatenated MPEG-2 TS packets may be present in four cases.", "The payload size of the link layer packet other than synchronous bytes (Sync Bytes) (47H) may also be identified by the count field.", "The number of MPEG-2 TS packets to be allocated according to the count field value may be changed according to system designers.", "FIG.", "17 is a conceptual diagram illustrating a header of the MPEG-2 TS packet according to an embodiment of the present invention.", "Referring to FIG.", "47, the header of the MPEG-2 TS packet may include a Sync Byte field, a Transport Error Indicator field, a payload unit start indicator field, a transport priority field, a PID field, a transport scrambling control field, an adaptation field control field, and/or a continuity counter field.", "The Sync Byte field may be used for packel synchronization, and may be excluded in the case of encapsulation at the link layer.", "A transport error indicator (EI) located next to the Sync Byte field is not used by the transmitter, and may be used to inform a higher layer of the presence of an error incapable of being recovered by the receiver.", "As a result, the Transport lirror Indicator field is not used by the transmitter.", "The Transport Error Indicator field is established in a demodulation process on the condition that it is impossible to correct errors of the stream.", "In more detail, the Transport Error Indicator field may indicate the presence of errors incapable of being corrected in the packet.", "The payload unit start indicator field may identify whether PES (Packctizcd elementary stream) or PSI (Program-specific information) is started.", "The transport priority field may indicate whether the corresponding packet has a higher priority than other (jackets having the same PID.", "The PID field may identify each packet.", "The transport scrambling control field may indicate whether or not a scramble is used, and/or may indicate whether a scramble is used using an odd or even key.", "The adaptation fiekl control field may indicate the presence or absence of the adaptation field.", "The continuity counter field may indicate an order number (or sequence number( of the payload packet.", "FIG.", "48 is a conceptual diagram illustrating a process for allowing a transceiver to change a usage of a transport error indicator field according to an embodiment of the present invention.", "If the Di field is set to 1, the Transport Error Indicator field may be used as a Deletion Point Indicator (DPI) field in the link layer of the transmitter as shown in FIG.", "19.The Deletion Point Indicator (DPI) field may be recovered to the Transport Error Indicator field after completion of the null packet-related processing in the link layer of the receiver.", "That is, the DI field may indicate whether the null packet is deleted, and at the same time may indicate whether the usage of the Transport Error Indicator field of the MPEG-2 TS header is changed.", "FIG.", "49 is a conceptual diagram illustrating an encapsulation process of the MPEG-2 TS packet according loan embodiment of the present invention.", "Basically, the MPEG-2 TS packet concatenation is being considered, so that a plurality of MPEG-2 TS packets may be contained in the payload of one link layer packet, and the number of MPEG-2 TS packets may be decided as described above.", "Assuming that the number of MPFG-2 TS packets contained in payload of one link layer packet is denoted by N, respective MPEG-2 TS packets may be denoted by Mk (wherein 1≤k≤n).", "The MPEG-2 TS packet may include a fixed header of 4 bytes and a payload of 184 bytes.", "1 byte from among the header of 4 bytes is used as the Sync Byte, and is always assigned the same value (47H).", "Accordingly, one MPEG-2 TS packet ‘Mk’ may include the sync part (S) of 1 byte, a fixed header part (Hk) of 3 bytes other than the sync byte, and/or the payload part (Pk) of 184 bytes (wherein 1≤k≤n).", "If the adaptation field is used in the header of the MPEG-2 TS packet, the fixed header part is extended even to the front part of the adaptation field, and the remaining adaptation parts are contained in the payload part.", "Assuming that N MPEG-2 TS packets are denoted by [M1, M2, M3, .", ".", ".", ", Mn].", "the N MPEG-2 TS packets are arranged in the form of [S, H1, P1, S, H2, P2, .", ".", ".", ", S, Hn, Pn].", "The Sync Part always set to the same value, such that the receiver can detect the corresponding position without receiving any signal from the transmitter, and can perform the insertion action at the detected position.", "Accordingly, when the payload of the link layer packet is constructed the sync part is excluded so that the packet can be reduced in size.", "When an aggregate of the MPEG-2 TS packets having the above arrangement is constructed as the payload of the link layer packet, the sync part is excluded, and the header part and the payload part are separated from each other, so that the MPEG-2 TS packets are arranged in the form of [H1, H2, .", ".", ".", ", Hn, P1, P2, .", ".", ".", ", Pn].", "If the PI field value is set to zero ‘0’ and the D1 field is set to zero ‘0’, the payload length of the link layer packet has ‘(n×3)+(n×184)’ bytes.", "Thereafter, if 1 byte indicating the header length of the link layer packet is added to the resultant bytes, the entire link layer packet length can be calculated and obtained.", "That is, the receiver can identify the length of the link layer packet through the above-mentioned process.", "FIG.", "50 is a conceptual diagram illustrating an encapsulation process of the MPEG-2 TS packet having the same PID according to an embodiment of the present invention.", "If broadcast data is being successively streamed, the MPEG-2 TSs contained in one link layer packet may have the same PDI value.", "In this case, repented PID values are simultaneously indicated so that the link layer packet can be reduced in size.", "In this case, the PI (PID indicator) field contained in the header of the link layer packet may be used as necessary.", "The PI (Common PID Indicator) value of the header of the link layer packet may be set to ‘1’.", "As described above, in the case of using N MPEG-2 TS packets [M1, M2, M3, .", ".", ".", ", Mn] within the payload of she link layer packet, the sync part is excluded, and the header part and the payload part are separated from each other, so dial the MPEG-2 TS packets may be arranged in the form of [H1, H2, .", ".", ".", ", Hn.", "P1, P2, .", ".", ".", ", Pn].", "In this case, the header parts [H1, H2, .", ".", ".", ", Hn] of the MPEG-2 TS may have the same PID.", "Although the PID value is indicated and transmitted only once, the receiver can recover the corresponding data to an original header.", "Assuming that a common PID is referred to as a Common PID (CPID) and the header obtained when the PID is excluded from the MPEG-2 TS packet header (Hk) is denoted by H*k (where 1≤k≤n), the header parts [H1, H2, .", ".", ".", ", Hn] of the MPEG-2 TS constructing the payload of the link layer packet may be reconstructed in the form of [CPID, H*1, H*2, .", ".", ".", ", H*n].", "This process may be referred to as Common PID reduction.", "FIG.", "51 is a conceptual diagram illustrating an equation for calculating the length of a link layer packet through a Common PID reduction process and a Common PID reduction process.", "Referring to FIG.", "51, the header part of the MPEG-2 TS packet may include a PID of 13 bits.", "If the MPEG-2 TS packets configured to construct the payload of the link layer packet have the same PID values.", "PID is repeated a predetermined number of times corresponding to the number of concatenated packets.", "Accordingly, the PID part is excluded from the header parts [H1, H2, .", ".", ".", ", Hn] of the original MPEG-2 TS packet, so thai the MPEG-2 TS packets are reconstructed in the form of [H*1, H*2, .", ".", ".", ", H*n], the common PID value is set to the CPID value, and the CIPD may be located at the front of the reconstructed header put The PID value has the length of 13 bits, and the sniffing bit may be added in a manner that the entire packet is configured in the form of a byte unit.", "The stuffing bits may be located at the front or rear part of the CPID.", "The stuffing bits may be properly arranged according to the structure of concatenated protocol layer or the system implementation.", "In the case of encapsulating the MPEG-2 TS packets having the same PID, the PID is excluded from the header part of the MPEG-2 TS packets and then encapsulated, and the payload length of the link layer packet can be calculated as described above.", "As shown in FIG.", "51, the header of the MPEG-2 TS packet other than the Sync Byte is 3 bytes long.", "If the PID part of 13 bits is excluded, resulting in the implementation of 11 bits.", "Accordingly, if N packets are concatenated to implement (n×11) bits, and if the number of concatenated packets is set to a multiple of 8, the (n×11) bits have the length of a byte unit.", "The stuffing bits having the length of 3 bits are added to the common PID length of 13 bits, so that the CPID part having the length of 2 bytes can be constructed.", "Therefore, in the case of using the link layer packet obtained when N MPEG-2 TS packets having the same PID are encapsulated, assuming that the length of the header of the link layer packet is denoted by LH, the CPID part has the length of LCPID, and a total length of the link layer packet is denoted by LT, the LT value can be calculated as shown in the equation of FIG.", "51.In the embodiment of FIG.", "21.LH is 1 byte, and LCPID is 2 bytes.", "FIG.", "52 is a conceptual diagram illustrating the number of concatenated MPEG-2 TS packets and the length of a link layer packet according to count field values when Common PID reduction is used.", "If the number of concatenated MPEG-2 TS packets is decided, and if all packer have the same PID, the above-mentioned common PID reduction process can be applied, and the receiver can calculate the length of the link layer packets according to the above-mentioned equation.", "FIG.", "53 is a conceptual diagram illustrating a process for encapsulating the MPEG-2 TS packet including a null packet according to an embodiment of the present invention.", "In order to transmit the MPEG-2 TS packet at a fixed transfer rate, the null packet may be contained in the transmission (Tx) stream.", "The null packet is used as overhead in terms of a transmission aspect, and thus, although the transmitter does not the null packet, the receiver can recover this null packet.", "When the transmitter deletes the null packet and transmits data and the receiver searches for the number of deleted null packets and the location of deleted null packets so as to perform data recovery, the null packet deletion indicator (DI) field located in the header of the link layer packet may be used.", "In this case, the DI value of the header of the link layer packet may be set to 1.The encapsulation action when the null packet is located at an arbitrary position between input Tx streams may be carried in a maimer that n packets other than the null packet are sequentially concatenated.", "Tlie count value indicating how many null packets are successively excluded may be contained in the payload of the link layer packet, and the receiver may generate the null packet at an original position on the basis of this count value so that the original position is filled with the null packet.", "Assuming that N MPEG-2 TS packets oiher than the null packet are denoted by [M1, M2, M3, .", ".", ".", ", Mn], the null packet may appear ai any position between the MPEG-2 TS packets (M1-Mn).", "The part at which the null packet is counted a predetermined number of limes from among 0-n times may appear in a single link layer packei.", "That is, assuming that the appearance number of times of the above part at which the null packet is counted within one link layer packet is denoted by ‘p’ the range of p is denoted by 0 to n. If the count value of each null packet is denoted by Cm, the range of m is denoted by 1≤m≤p, and Cm does not exist in case of p=0.Specific information indicating where each Cm is located between the MPEG-2 TS packets may be denoted using a specific field in which the usage of EI (transport error indicator) is changed to DP (Deletion Point Indicator) in the header of the MPEG-2 TS packet.", "In the present invention.", "Cm may have the length of 1 byte.", "If the packet to be used later has a margin in length, the 1-byte Cm may also be extended.", "Cm of 1 byte may count a maximum of 256 null packets.", "The indicator field of the null packets is located at the header of the MPEG-2 TS packet, and the exclusion of a predetermined number of null packets corresponding to “(value denoted by Cm)+1” can be calculated, for example, in case of Cm=0, one null packet may be excluded.", "In case of Cm=123, 124 null packets are excluded.", "If the number of contiguous null packets is higher than 256, the 257-th null packets are processed as normal packets, and the subsequent null packets can be processed as such null packets according to the above-mentioned method.", "As shown in FIG.", "24, the null packet is located between the MPEG-2 TS packets corresponding to Mi and Mi+1.The count value of the MPEG-2 TS packets is denoted by CI, and the null packet is located between the MPEG-2 TS packets corresponding to Mj and Mj+1.If the count value of the MPEG-2 TS packets may be denoted by Cp, the actual transmission order may be denoted by [ .", ".", ".", ", Mi, C1, Mi+1, .", ".", ".", ", Mj, Cp, Mj+1, .", ".", ".", "].", "When the header part and the payload part of the MPEG-2 TS packet, instead of the null packet, are separated from each other and rearranged to construct the payload of the link layer packet, the count value Cm (1≤m≤p) of the null packets is located between the header part and the payload part of the MPEG-2 TS packet.", "That is, the payload of the link layer packets are arranged in the form of [H1, H2, .", ".", ".", ", Hn, C1, .", ".", ".", ", Cp, P1, P2, .", ".", ".", ", Pn], and the receiver confirms the count value one byte by one byte in the order shown in the DPI field located at Hk, and recovers as many null packets as the number of confirmed value according to the order of original MPEG-2 TS packets.", "FIG.", "54 is a conceptual diagram illustrating a step for processing an indicator configured to count a removed null packet and an equation for calculating the length of a link layer packet in the processing step.", "The DPI field may be established to indicate deletion of the null packet and the presence of a count value associated with the deleted null packet.", "As shown in FIG.", "25, if the DPI field present at Hi from among the header of a plurality of MPEG-2 TS packets is set to 1, this means that the null packet located between Hi and Hi+1 is excluded and encapsulated, and its associated 1-byte count value is located between the header part and the payload part.", "In the above-mentioned process, the length of the link layer packet can be calculated by the equation shown in FIG.", "54.Therefore, in case of the link layer packet that has been obtained by encapsulation of n MPF.G-2 TS packets through the null packet exclusion process, assuming that the header length of the link layer packet is denoted by LH, the count value Cm (1≤m≤p) of the null packets is denoted by LCount, and the total length of the link layer packet is denoted by LT. LT can be calculated by the equation of FIG.", "54.FIG.", "55 is a conceptual diagram illustrating a process for encapsulating the MPEG-2 TS packet including a null packet according to another embodiment of the present invention.", "In accordance with another embodiment of the encapsulation method excluding the null packets, payload of the link layer packet can be constructed.", "In accordance with another embodiment of the present invention, when the header part and payload part of the MPEG-2 TS packets are rearranged to construct the link layer packet payload, the count value Cm (1≤m≤p) of the null packets can be located at the header part and the order or sequence of the null packets may remain unchanged.", "That is, the count value of the null packets may be contained at a specific point at which individual MPEG-2 TS headers are ended.", "Accordingly, when the receiver reads a value of the DPI field contained in each MPEG-2 TS header, the receiver determines completion of the deletion of null packets, the receiver reads the count value contained at the last part of the corresponding header, and regenerates as many null packets as the corresponding count value, such that the regenerated null packets may be contained in the stream.", "FIG.", "56 is a conceptual diagram illustrating a process for encapsulating the MPEG-2 TS packets including the same packet identifiers (PIDs) in a stream including a null packet according to an embodiment of the present invention.", "The encapsulation process of MPEG-2 TS packets including the same PID (packet identifier) in the stream including the null packet may be carried out by combination of a first process for encapsulating the link layer packets other than the above null packets and a second process for encapsulating the MPEG-2 TS packets having the same ID into the link layer packet.", "Since an additional PID indicating the null packet is allocated, the case in which the null packet is contained in the actual transmission stream is no; processed by the same PID.", "However, alter completion of the exclusion process of the null packets, only the count value related to the null packet is contained in the payload of the link layer packet, the remaining N MPEG-2 TS packets have the same PID, such that the N MPEG-2 TS packets can be processed by the above-mentioned method FIG.", "57 is a conceptual diagram illustrating an equation for calculating the length of a link layer packet when the MPEG-2 TS packets having the same PlDs are encapsulated in a stream including a null packet according to an embodiment of the present invention.", "In the stream including the null packet, when MPEG-2 TS packets having the same PID are encapsulated, the lengdi of the link layer packet can be calculated through FIG.", "51 and/or FIG.", "54.The above equations can be represented by an equation of FIG.", "28.FIG.", "58 is a conceptual diagram illustrating a link layer packet structure for transmitting signaling information according loan embodiment of the present invention.", "In order to transmit signaling information before the receiver receives the IP packet or the MPEG-2 TS packet in the same manner as in the update process of IP header compression information or broadcast channel scan information, the present invention provides packet formats capable of transmitting signaling data (i.e., signaling data) to the link layer.", "In accordance with the embodiment of the present invention, if the packet type element contained in the header of the link layer packet is set to 110B, a section table (or a descriptor) for signaling may be contained tn the payload of the fink layer packet and then transmitted.", "The signaling section table may include a signaling table/table section contained in conventional DVB-SI (service information).", "PSI/PSIP, NRT (Non Real Time), ATSC 2.0, and MH (Mobile/Handheld).", "FIG.", "59 is a conceptual diagram illustrating a link layer packet structure for transmitting the framed packet according to an embodiment of the present invention.", "Besides the IP packet or the MPEG-2 TS packet, the packet used in a general network can be transmitted through the link layer packet.", "In this case, the packet type element of the header of the link layer packet may be set to 111B, and may indicate that the framed packet is contained in the payload of the link layer packet.", "FIG.", "60 shows a syntax of the framed packet according to an embodiment of the present invention.", "The syntax of framed packet may include ethernet_type, length, and/or packet( ).", "The ethernet_type which is a 16-bit field shall identify the type of packet in the packet( ) field according to the IANA registry.", "Only registered values shall be used.", "The length which is a 16-bit field shall be set to the total length in bytes of the packet( ) structure.", "The packet( ) which is variable length field shall contain a network packet.", "FIG.", "61 is a block diagram illustrating a receiver of the next generation broadcast system according to an embodiment of the present invention.", "Referring to FIG.", "61, the receiver according to an embodiment of the present invention may include a receiver (not shown), a Channel Synchronizer 32010, a Channel Equalizer 32020, a Channel Decoder 32030, a Signaling Decoder 32040, a Baseband Operation Controller 32050, a Service Map DB 32060, a Transport Packet Interface 32070, a Broadband Packet Interface 32080, a Common Protocol Stack 32090, a Service Signaling Channel Processing Buffer & Parser 32100, an A/V Processor 32110, a Service Guide Processor 32120, an Application Processor 32130, and/or a Service Guide DB 32140.The receiver (not shown) may receive broadcast signals.", "The channel synchronizer 32010 may synchronize a symbol frequency with timing in a manner that signals received at baseband can be decoded.", "In this case, the baseband may indicate a Tx/Rx region of the broadcast signal.", "The channel equalizer 32020 may perform channel equalization of the received (Rx) signal.", "The channel equalizer 32020 may compensate for signal distortion encountered when the Rx signals are distorted by mullipath.", "Doppler effect, etc.", "The Channel Decoder 32030 may recover the received (Rx) signal into a meaningful transport frame.", "The channel decoder 32030 may perform forward error correction (FEC) of data or transport frame contained in the Rx signal.", "The signaling decoder 32040 may extract and decode signaling data contained in the received (Rx) signal.", "Here, the signaling data may include signaling data and/or service information (SI) to be described later.", "The baseband operation controller 32050 may control baseband signal processing.", "The Service Map DB 32060 may store signaling data and/or service information.", "The service Map DB 32060 may store signaling data contained/transmitted in the broadcast signal and/or signaling data contained/transmitted in the broadband packet.", "The transport packet interface 32070 may extract the transport packet from the transmission (Tx) frame or the broadcast signal.", "The transport packet interface 32070 may extract the signaling data or the IP datagram from the transport packet.", "The broadband packet interface 32080 may receive broadcast-related pockets through the Internet.", "The broadband packet interface 32080 may extract a packet obtained through the Internet, and combine or extract the signaling data or A/V data from the corresponding packet.", "The common protocol stack 32090 may process the received packet according to the protocol contained in the protocol slack.", "For example, the common protocol stack 32090 may perform processing for each protocol, such that it can process the received packet.", "The service signaling channel processing buffer & parser 32100 may extract signaling data contained in the received packet.", "The service signaling channel processing buffer & parser 32100 may scan services and/or contents from the IP datagram or the like, and may extract signaling information related to acquisition of the services and/or contents, and parse the extracted signaling information.", "The signaling data may be located at a predetermined position or channel within the received packet.", "This position or channel may be referred to as a service signaling channel.", "For example, the service signaling channel may have a specific IP address, a UDP Port number, a transmission session ID, etc.", "The receiver may recognize data being transmitted as the specific IP address, the UDP port number, and the transmission session, etc, as signaling data.", "The A/V Processor 32110 may perform decoding of the received audio and video data, and presentation processing thereof.", "The service guide processor 32120 may extract announcement information from the Rx signal, may manage the service guide DB 32140, and provide the service guide.", "The application processor 32130 may extract application data contained in the received packet and/or application-associated information, and may process the extracted data or information.", "The service guide DB 32140 may store the service guide data therein.", "FIG.", "62 is a conceptual diagram illustrating a general format of a section table according to an embodiment of the present invention.", "Referring to FIG.", "62, the section table according to an embodiment may include a table_id field, a section_syntax_indicalor field, a section_length field, a version number field, a current_next_indicator field, a section_number field, a last_section_number field, and/or a section data field.", "The table_id field may indicate a unique ID value of the corresponding table.", "The section_syntax_indicator field may indicate a format of a table section located behind the corresponding field.", "If the corresponding field is set to zero (0), the corresponding table section indicates a short format.", "If the corresponding field is set to 1, the corresponding table section has a general long format.", "The corresponding field value according to an embodiment of the present invention may always be set to 1.The section_length field may indicate the length of the corresponding section, such that it can indicate the length from the next part of the corresponding field to the last part of the corresponding section in bytes.", "The version_number field may indicate a version of the corresponding table.", "If the current_next_indicator field is set to 1, this means that the corresponding section table is valid.", "If the current next indicator field is set to 0, this means that the next section table to be subsequently transmitted is valid.", "The section_number field may indicate the number of sections contained in the corresponding table.", "If the first section constructing the corresponding table is decided, the section_number field value may indicate zero, and may also be sequentially increased.", "The last_section number field may indicate the number of the last section from among a plurality of sections constructing the corresponding table.", "The section data field may include data contained in the corresponding section.", "The field denoted by “Special Use” may be a field that can be differently configured according to individual tables.", "The number of bits allocated to “Special Use” may be maintained without change.", "FIG.", "63 is a conceptual diagram illustrating a link layer packet for transmitting signaling information according to an embodiment of the present invention.", "If signaling information is transmitted using the link layer packet, the value of the packet type element may be set to “110B”.", "FIG.", "63 shows a header structure of the link layer packet when signaling information is transmitted.", "Referring to FIG.", "63, during transmission of the signaling information, a signaling type field of 2 bits may be located behind the packet type element.", "The signaling type field may indicate a formal of the signaling information to be transmitted.", "The remaining 3-bit part of the fixed header subsequent to the signaling type field and the extended header may be decided.", "If the signaling type field according to an embodiment denotes ‘00B’, this means that the signaling type is a section table.", "In case of the section table, information regarding section separation and the section length information are contained in the field of the table, such that the link layer packet may indicate only the packet type and the signaling type without additional processing, and then transmit the packet type and the signaling type.", "If the signaling type has a section table format, the remaining 3 bits other than the packet type element and the signaling type field of the fixed header part are not in use, and may be reserved for a subsequent use.", "If the signaling type has a section table format, the extended header is not used.", "If there is a need to indicate the length of the link layer packet, the extended header of 1 or 2 bytes may be added and may be used as a length field.", "If the signaling type field according to the embodiment denotes ‘01B’, this means that the signaling type has a descriptor format.", "Generally, the descriptor is used as some parts of the section table.", "If only the descriptor needs to be transmitted through simple signaling, the descriptor may be transmitted as the corresponding signaling type.", "The descriptor may be shorter in length than the section table, so that several descriptors may be contained in one link layer packet and then transmitted.", "3 bits corresponding to the indicator part of the fixed header according to the embodiment may be used to indicate how many descriptors are contained in one link layer packet.", "If the signaling type is a descriptor format and the extended header is not in use, the length of the link layer packet can be displayed using the corresponding descriptor length information contained in the descriptor without using the extended header.", "If it is necessary to separately display the link layer packet length, the extended header of 1 or 2 bytes is added, and may be used as the length field.", "The signaling type field value (10B) according to an embodiment may be reserved to support other kinds of signaling.", "If the signaling type field according to the embodiment indicates the value of 11B, this means that the signaling type is GSE-LLC.", "The GSE-LLC signaling may be segmented as necessary.", "Therefore, if the signaling type is GSE-LLC, the remaining 3 bits other than the packet type element and the signaling type field of the fixed header part may be used as the segment ID.", "If the signaling type is GSE-LLC, the extended header of 2 bytes may be added, and may also be composed of Seg_SN (Segment Sequence Number) of 4 bits and the length field of 12 bits.", "GSE-LLC according to an embodiment is an abbreviation of Generic Stream Encapsulation Logical Link Control, and may indicate one of two affiliated layers of the data link layer of the OSI model.", "FIG.", "64 shows the meaning of values denoted by the signaling type field, and contents of a fixed header and an extended header located behind the signaling type field.", "If the signaling type field according to an embodiment indicates ‘00B’, the field subsequent to the signaling type field may not be present.", "If the signaling type field according to an embodiment indicates ‘01B’, the Concatenation Count (Count) field may be located behind the signaling type field.", "The Concatenation Count (Count) field may be present only when the descriptor instead of the section table is transmitted as signaling information.", "The Concatenation Count (Count) field may indicate how many descriptors are contained in payload of the link layer packet.", "A detailed description of the Concatenation Count (Count) will hereinafter be disclosed.", "If the signaling type field according to an embodiment indicates ‘11B’, the Seg_ID (Segment ID) field, the Seg_SN (Segment Sequence Number) field, and/or the length field may be located subsequent to the signaling type field.", "In case of LLC signaling data capable of being transmitted using DVB_GSE, the LLC signaling data may be autonomously segmented.", "When LLC data is segmented, the Seg_ID (Segment ID) field may indicate an ID for identifying the segmented data.", "If segments of the transmitted LLC data are integrated into one, the receiver may recognize that the segments of individual LLC data pieces are constituent elements of the same LLC data using the Seg_ID (Segment ID) field.", "The Seg_ID (Segment ID) field is 3 bits long, and may identify 8 segments (or 8 segmentations).", "If the Seg_SN (Segment Sequence Number) field is segmented, it may also indicate the order of respective segments.", "Since the index of the corresponding data table is contained in the front part of LLC data, individual segments generated when the receiver receives the packet must be sequentially aligned at all times.", "Although the link layer packets having payload segmented from one LLC data have the same Seg_ID, the link layer packets may have different segment sequence numbers (Seg_SN), and may be 4 longs long.", "One LLC data may be divided into a maximum of 16 segments.", "The length field may indicate the length of LLC data corresponding to the payload of the current link layer packet in bytes.", "Accordingly, a total length of the link layer packet may be denoted by “header length (3 bytes)+Value denoted by the length field”.", "DVB_GSE is an abbreviation of DVB-Genneric Stream Encapsulation, and may indicate the data link layer protocol defined by DVB.", "FIG.", "65 shows the number of descriptors contained in payload of the link layer packet according to a concatenation count field value according to an embodiment of the present invention.", "As many descriptors as the number of specific numerals each being denoted by “Concatenation Count (Count) field value+1” may construct payload of a single link layer packet.", "Accordingly, since the number of bits allocated to the Concatenation Count (Count) field is 3, a maximum of 8 descriptors may be composed of one link layer packet.", "FIG.", "66 is a conceptual diagram illustrating a process for encapsulating the section table into payload when signaling information input to the payload of the link layer packet is a section table.", "In accordance with one embodiment of the present invention, one section table may be used as the payload of the link layer packet without change.", "In this case, a value indicated by the packet type element may be 110B (signaling), and a value indicated by the signaling type field may be 00B (section table).", "The remaining 3 bits other than the packet type element and the signaling type field of the fixed header may be reserved for subsequent use.", "The field contained in the section table according to an embodiment may include a field indicating the length of the corresponding section.", "The field indicating the length of the corresponding section may always be located at the same position, and the field shifted from the beginning of the payload of the link layer packet by a predetermined offset is confirmed, so that the payload length can be confirmed.", "In case of the section table, the section length (section_length) field of 12 bits may be present at a specific position corresponding to movement of 12 bits on the basis of the beginning part of payload.", "The section_length_field may indicate the length from a part subsequent to the section_length_field to the last part of the section.", "Therefore, a specific part not contained in the section length field and the header length of the link layer packet are added to a specific value indicated by the section length field, so that the length of a total link layer packet can be derived.", "In this case, the part (3 bytes) not contained in the section length field may include a length of the table ID field (table_id_field) and a length of the section length field (section_length_field) of the section table.", "The header length of the link layer packet may be 1 byte long.", "That is, the total length of the link layer packet may be identical to “4 bytes+Value denoted by the section length field”.", "If the receiver according to the embodiment receives the link layer packet including the section table, the receiver may obtain/use information regarding the corresponding section table through the table ID field (table_id_field) of 8 bits located subsequent to the fixed header of the link layer packet.", "FIG.", "67 is a conceptual diagram illustrating a syntax of a network information table (NIT) according to an embodiment of the present invention.", "In accordance with the embodiment of the present invention, if the section table for signaling is contained in payload of the link layer packet and the resultant section able is transmitted, a network information table indicating information related to the current broadcast network may be contained as the section table in ihc payload of the link layer packet.", "The network information table according to the embodiment may include a table_id_field, a section_syntax_indicator field, a section_length field, a network_id field, a version_number field, a current_next_indicator field, a section_number field, a last_section_number field, a network_descripiors_length field, a descriptor( ) field, a transport_stream_loop_length field, a broadcast_id field, an original_network_id field, a delivery_system_descriptor_length field, and/or a delivery_system_descriptor( ) field.", "From among a plurality of fields contained in the network information table according to the embodiment, some fields having the same titles as the fields described in the drawing showing a general format of the above-mentioned section table may be replaced with the above-mentioneded description.", "Inc network_id field may indicate a unique ID of the broadcast network being currently used.", "The network _descriptors_length field may indicate the length of descriptor indicating the network associated information at the network level.", "The descriptor( ) may indicate a descriptor showing the network associated information at a network level.", "The transport_stream_loop_length field may indicate the length of stream associated information that is transmitted on the broadcast network.", "The broadcast_id field may indicate a unique ID of a broadcast station existing in the broadcast network.", "The original_network _id field may indicate a unique ID of the broadcast network having been originally used.", "If the originally used broadcast network is different from the current broadcast network, NIT may include information regarding the broadcast network that has been originally used through the original_network_id field.", "The delivery_systcm_descriptor_length field mas indicate the length of the descriptor indicating detailed information related to the delivery system (deli very _syslem) on the current broadcast network.", "The delivery_system_descriptor( ) indicate a descriptor including detailed information associated with the delivery system (delivery_system) on the current broadcast network.", "FIG.", "68 is a conceptual diagram illustrating a syntax of a delivery system descriptor contained in a network information table (NIT) according to an embodiment of the present invention.", "Referring to FIG.", "68, the delivery system descriptor according to the embodiment may include information of Physical Layer Pipe (PLP) configured to transmit signaling data related to data transferred from a specific broadcast station on the transmit (Tx) system.", "The delivery system descriptor may include a descriptor _tag field, a descriptor_length field, a delivery_system_id field, a base_PLP_id field, a base_PIP_version field, and/or a delivery_system_parameter( ) field.", "The descriptor_tag field may indicate an identifier for indicating that the corresponding descriptor is a delivery system descriptor.", "The descriptor_length field may indicate the length of the corresponding descriptor.", "The delivery_system_id field may indicate a unique delivery system ID of the broadcast network.", "The base_PLP_id field may indicate a representative PLP (Physical Layer Pipe) for decoding components of the broadcast service transmitted from a specific broadcast station identified by ‘broadcast_id’.", "In this case, PLP may indicate a data pipe of a physical layer, and may include PSI/SI information or the like in a broadcast service transmitted from a specific broadcast station.", "The base_PLP_version field may indicate version information according to variation of data transmitted through PLP identified by ‘base_PLP_id’.", "For example, if service signaling such as PSI-SI is transferred through base_PLP, the base_PLP_version field value may be increased by one whenever the service signaling is changed.", "The delivery _sytem_parameters( ) field may include parameters for indicating characteristics of the broadcast delivery system.", "The parameters may include a bandwidth, a guard interval, a transmission mode, a center frequency, etc.", "FIG.", "69 is a conceptual diagram illustrating a syntax of a fast information table (FFT) according to an embodiment of the present invention.", "In accordance with one embodiment, it the section table for signaling is contained in payload of the link layer packet and is then transmitted, a fast information table (FIT) may be contained as a section table in the payload of the link layer packet.", "The receiver according to an embodiment may quickly and easily scan and obtain the broadcast service through the fast information table (FIT).", "The fast information table (FIT) may include a table_id field, a private indicator field, a section_length_field, a table_id_extension field, a FIT_data version field, a current_next_indicator field, a section_number field, a last_section_number field, a num_broadcast field, a broadcast_id field, a delivery_system_id field, a base_PLP_id field, a base_PLP_version field, a num_service field, a service_id field, a service_category field, a service_hidden_flag field, an SP_indicator field, a num_component field, a component_id field, and or a PLP_id field.", "From among a plurality of fields contained in the fast information table (FIT) according to the embodiment some fields having the same titles as the fields described in the drawing showing a general format of the above-mentioned section table may be replaced with the above-mentioned description.", "The table_id field may indicate that the corresponding table includes information related to quick scanning of the service and the corresponding table corresponds to the fast information table (FIT).", "The private_indicator field may always be set to 1.The table_id_extension field may correspond to some parts of the table_id field, and provide a scope for the remaining fields.", "The FIT_data_version field may indicate version information of the syntax and semantics contained in the fast information table (FIT).", "The receiver according to the embodiment may decide whether signaling information contained in the corresponding table is processed using the FIT_data_version field.", "The num_broadcast field may indicate the number of broadcast stations configured to transmit a broadcast service or content through a frequency or a transmitted transport frame.", "The broadcast id field may indicate a unique ID of the broadcast station configured to transmit a broadcast service or content through a field frequency or a transmitted transport frame.", "In case of the broadcast station configured to transmit MPEG-2 TS based data, the broadcast_id field may include the same value as in “transport_stream_id” of MPEG-2 TS.", "The delivery_system_id field may indicate an identifier of the broadcast delivery system configured to use the same transmit parameter on the broadcast network.", "The base_PLP_id field may indicate an identifier of PLP configured to transmit the broadcast service signaling information transferred from a specific broadcast station identified by ‘broadcast_id’.", "The base_PLP_id field may indicate a representative PLP for decoding components of the broadcast service transmitted from a specific broadcast station identified by ‘broadcast_id’.", "In this case, PLP may indicate a data pipe of the physical layer, and may include PSI/SI information in the broadcast service transferred from a specific broadcast station.", "The base_PLP_version field may indicate version information according to variation of data transmitted through PLP identified by ‘base_PLP_id’.", "For example, if service signaling information such as PSI/SI is transferred through ‘base_PLP’, the base_PLP_version field value may be increased by one whenever the service signaling information is changed.", "The num_service field may indicate the number of broadcast services transferred from a broadcast station identified by ‘broadcast_id’ within the corresponding frequency or a transport frame.", "The service_id field may indicate an ID for identifying the broadcast service.", "The service_category field may indicate a category of the broadcast service.", "For example, if the service_category field value is 0x01, this means Basic TV.", "If the service_category field value is 0x02, this means Basic Radio.", "If the service_category field value is 0x03, this means RI service.", "If the service_category field value is 0x08, this means Service Guide.", "If the service_category field value is 0x09, this means Emergency Alerting.", "The service_hidden_flag field may indicate whether the corresponding broadcast service is hidden or not.", "If the corresponding broadcast service is hidden, the corresponding service may correspond to a test service or a service being autonomously used, so that the receiver according to the embodiment may disregard the above-mentioned hidden broadcast service or may allow the hidden broadcast service to be hidden from the service list.", "The SP_indicator field may indkale whether service protection is applied to one or more components of the corresponding broadcast service.", "The num_component field may indicate the number of components contained in the corresponding broadcast service.", "The component_id field may indicate an ID for identifying the corresponding component of the broadcast service.", "The PLP_id field may indicate an identifier for identifying PLP through which the corresponding component is transmitted within the broadcast service.", "FIG.", "70 is a conceptual diagram illustrating a process for encapsulating a descriptor into payload when signaling information input to payload of the link layer packet is a descriptor.", "In accordance with one embodiment, one or more descriptors may be contained in the payload of the link layer packet.", "In this case, a value indicated by the packet type element is set to 110B (signaling), and a value indicated by the signaling type field may be set to 01B (descriptor).", "In FIG.", "70, the remaining 3 bits other than the packet type element and the signaling type field of the fixed header may indicate a count field that indicates how many descriptors are contained in the payload of a single link layer packet.", "The payload of the single link layer packet may include a maximum of 8 descriptors.", "In accordance with one embodiment, all descriptors may include a descriptor jag field of 1 byte and a descriptor length field of 1 byte in the beginning part of the descriptor.", "In accordance with one embodiment, the length of a concatenated packet can be calculated using the descriptor_length field.", "The descriptor_length field is always located at the same position within the descriptor, such that a field located at a specific position shifted from the beginning part of the payload of the link layer packet by a predetermined offset is confirmed and therefore the payload length can be confirmed.", "In case of the descriptor, the descriptor_length field of 8 bits at a specific position shifted from the beginning part of the payload by 8 bits may be present.", "The descriptor_length field may indicate the length from a part located behind the corresponding field to the last part of the descriptor.", "Therefore, “the length (1 byte) of the descriptors field not contained in the descriptor_length field+the length (1 bytes) of the descriptor length field” are added to a specific value denoted by the descriptor_length field, so that the length of one descriptor can be derived.", "As many descriptor lengths as the number of descriptors indicated by the count field are added so that the length of a total link layer packet can be derived, for example, a second descriptor contained in the payload of the link layer packet according to an embodiment may start from a specific position shifted from the beginning part of the payload by the length of a first descriptor, the descriptor_length field of the second descriptor is located at a specific position shifted from the beginning part of the second descriptor by a predetermined offset, and the descriptor_length field is confirmed, so that the total length of the second descriptor can be derived.", "By the above-mentioned processes, the length of each descriptor contained in the payload of the link layer packet may be calculated, and the header length of the link layer packet is added to the sunt of the lengths of individual descriptors, so that a total length of the link layer packet can be calculated.", "If the receiver receives the link layer packets including one or more descriptors, the receiver may obtain use the signaling information contained in each descriptor through the 8-bit descriptor_tag field value contained in each descriptor.", "FIG.", "71 if a conceptual diagram illustrating a syntax of a fast information descriptor according to an embodiment of the present invention.", "In accordance with the embodiment, if the descriptor for signaling is contained in the payload of the link layer packet and then transmitted, the fast information descriptor may be contained in the payload of the link layer packet.", "The receiver may quickly and easily scan and obtain the broadcast service through the fast information descriptor.", "The fast information descriptor according to an embodiment may include a descriptor_tag field, a descriptor_length field, a num_broadcast field, broadcast_id field, a delivery_system_id field, a base_PLP_id field, a base_PLP_version field, a num_service field, a service_id field, a service_category field, a service_hidden_flag field, and/or an SP_indicator field.", "From among a plurality of fields contained in the fast information descriptor according to the embodiment, some fields having the same titles as the fields described in the drawing showing a general format of the above-mentioned section table may be replaced with the above-mentioned description.", "The descriptor_tag field may indicate a fast information descriptor indicating that the corresponding descriptor includes information related to quick service scanning.", "The descriptor_length field may indicate the length of the corresponding descriptor.", "FIG.", "72 is a conceptual diagram illustrating a delivery system descriptor according to an embodiment of the present invention.", "In accordance with one embodiment, if the descriptor for signaling is contained in the payload of the link layer packet and then transmitted, the delivery system descriptor may be contained in the payload of the link layer packet.", "The delivery system descriptor may include information regarding PLP (Physical Layer Pipe) configured to transmit signaling data related to data transferred from a specific broadcast station on the transmit (Tx) system.", "The delivery system descriptor according to the embodiment may include a descriptor_tag field, descriptor_length field, a delivery_system_id field, a num_broadcast field, a base_PLP_id field, a base PLP_version_field, a delivery_system_parameter_length field, and/or a delivery_system_parameters( ) field.", "The descriptor_tag may indicate that the corresponding descriptor is a delivery system descriptor.", "The descriptor_length field may indicate the length of the corresponding descriptor.", "The delivery_system_id field may indicate an ID for identifying a delivery system configured to transmit the same transmit (Tx) parameters on the broadcast network.", "The num_broadcast field may indicate the number of broadcast stations configured to transmit a broadcast service or content through a frequency or a transmitted transport frame.", "The base_PLP_id field may indicate a representative PLP (Physical Layer Pipe) for decoding constituent components of the broadcast service transferred from a specific broadcast station identified by ‘broadcast_id’.", "In this case, PLP may denote a data pipe of the physical layer, and may include PSI/SI information in the broadcast service transferred from a specific broadcast station.", "The base_PLP_version field may indicate version information according to variation of data transferred through PLP identified by base_PLP_id.", "For example, if service signaling such as PSI/SI is transferred through base_PLP, the base_PLP_version field value may be increased by one whenever the service signaling is changed.", "The delivery_system_parameters_length field may indicate the length of delivery_system_parameters( ) subsequent to the corresponding field.", "The delivery_system_parameters( ) field may include parameters for indicating characteristics of the broadcast delivery system.", "The parameters may include a bandwidth, a guard interval, a transmission mode, a center frequency, etc.", "The delivery system descriptor according to the embodiment may be contained in the network information table (NIT) and then transmitted.", "If the delivery system descriptor is contained in the network information table (NIT) and then transmitted, a syntax of the delivery system descriptor has already been disclosed in the detailed description of the network information table (NIT).", "FIG.", "73 is a conceptual diagram illustrating a process for encapsulating one GSE-LLC datum into payload of one link layer packet when signaling information input to payload of the link layer packet has a GSE-LLC format used in DVB-GSE.", "LLC data according to one embodiment may be classified into an index part and a record part.", "The record part may also be classified into a few tables.", "In this case, the table constructing the record part may have a GSB table structure, and may also have a general section table structure.", "In FIG.", "73, one LLC datum may be used as payload of a single link layer packet.", "In this case, a value indicated by the packet type element may be 110B (signaling), and a value indicated by the signaling type field may be 11B (GSE-LLC).", "If GSE-LLC formatted signaling information is transferred, the link layer packet may have an extended header of 2 bytes.", "The extended header of 2 bytes may be composed of the Seg_SN (segment sequence number) of 4 bytes and the length field of 12 bits.", "The length field may be assigned a specific value indicating a total length of the link layer packet according to a system structure, or may also be assigned a value indicating the payload length of the link layer packet.", "FIG.", "74 is a conceptual diagram illustrating a process for encapsulating one GSE-LLC datum into payload of several link layer packets when signaling information input to payload of the link layer packet has a GSE-LLC format used in a DVB-GSE standard.", "If LLC data is segmented, the Seg_ID fields indicating segmentation from LLC data may have the same value.", "The Seg_SN field may include the order of segments in such a manner that the receiver according to the embodiment receives and recombines the segmented LLC data.", "If one LLC datum is contained in the payload of the single link layer packet, the Seg_SN field may be set to zero (0).", "The receiver according to the embodiment may recognize the number of segments of LLC data related to the corresponding Seg_ID through the LLC index part.", "FIG.", "75 illustrates a header of a link layer packet for Robust Header Compression (RoHC) transmission according to the present invention.", "In an Internet Protocol (IP)-based broadcast environment, an IP packet may be compressed into the above-described link layer packet and be transmitted.", "When streaming is performed in an IP-based broadcast system, information about a header of the IP packet may be rarely changed and maintained.", "Based on this fact, the header of the IP packet may be compressed.", "All RoHC scheme is mainly used to compress the header of the IP packet (which is also referred to as an IP header).", "The present invention proposes a compression (encapsulation) scheme for a case in which an RoHC packet is input to a link layer.", "When the RoHC packet is input to the link layer, the above-described packet type element may have a value 010B.", "The value indicates that a packet delivered from the higher layer to the link layer is a compressed IP packet as described above.", "When the RoHO packet is input, the header of the link layer packet may include a fixed header and/or an extended header similarly to the other packets described above.", "The fixed header may include a packet type field and/or a packet configuration (PC) field.", "The fixed header may have a size of 1 byte in total.", "Here, the packet type field corresponds to a case of the compressed IP packet and thus may have a value of 010.The extended header may have a size which is fixed or varies according to a given embodiment.", "The PC field of the fixed header may be a field indicating a form in which the RoHC header included in a payload of the link layer packet is processed.", "The PC field has a value that may determine information about a remaining portion of the fixed header and the extended header following the PC field.", "In addition, the PC field may contain length information of the extended header based on the form in which the RoHC header is processed The PC field may have a size of 1 bit.", "A case in which the PC field has a value 0B will be described.", "The case in which the PC field has the value 0B corresponds to a case in which the payload of the link layer packet includes one RoHC packet or a concatenation of two or more RoHC packets.", "The concatenation indicates that several packets having short lengths are connected to each other to form the payload of the link layer packet.", "When the PC field has the value 0B, the PC field may be followed by a 1-bit common CID indicator (CI) field and a 3-bit count field.", "In this way, the extended header may be additionally provided with common CID information and a length part.", "The length part may be a part indicating a length of the RoHC packet.", "The CI field may be set to 1 when RoHC packets included in a payload of one link layer packet have the same context ID (CID), and be set to 0 otherwise.", "When the C field has a value 1, an overhead processing scheme for a common CID may be applied.", "The CI field may correspond to 1 bit.", "The count field may indicate the number of RoHC packets included in the payload of the one link layer packet.", "When a concatenation of RoHC packets is included, the number of the RoHC packets may be indicated by the count field, lite count field may correspond to 3 bits.", "Thus, a maximum of eight RoHC packets may be included in the payload of the one link layer packet as shown in Table 34 below.", "When the count field has a value 000, one RoHC packet rather than the concatenation of RoHC packets is included in the payload of the link layer packet.", "TABLE 34 Count (3 bits) No.", "of Concatenated RoHC packets 000 1 001 2 010 3 011 4 100 5 101 6 110 7 111 8 As described in the foregoing, the length part may be a part indicating a length of the RoHC packet.", "The RoMC packet has an RoHC packet header excluding length information.", "Thus, it is impossible to use a length field in the RoMC packet header.", "Therefore, the header of the link layer packet may include the length part to enable a receiver to be aware of a length of the RoHC packet.", "When a maximum transmission unit (MTU) is not determined, the IP packet has a maximum length of 65,535 bytes.", "Thus, 2-byte length information is required to support up to a maximum length of the RoHC packet.", "When a concatenation of several RoMC packets is included, length fields corresponding to the number designated in the count field may be additionally provided.", "In this case, the length part may include a plurality of length fields.", "However, when one RoHC packet is included in the payload, only one length field may be included.", "The length fields may be arranged in an order of the RoHC packets included in the payload of the link layer packet.", "Each of the length fields may have a value in bytes.", "A common CID field may be a field for transmission of the common CID.", "The RoHC packet may include a CID for verification of a relation between compressed headers in a header part.", "The CID may retain the same value in a stable link state.", "Therefore, all the RoHC packets included in the payload of the one link layer packet may include the same CID.", "In this case, to reduce overhead, CIDs may be removed from header parts of contiguous RoHC packets included in the payload, and an associated value may be displayed in the common CID field and be transmitted to the header of the link layer packet.", "The receiver may reeombine the CIDs of the RoHC packets using the common CID field.", "When the common CID field is present, the above-described CI field has a value 1.A case in which the PC field has a value 1B will be described.", "The case in which the PC field has the value 1B corresponds to a case in which the payload of the link layer packet includes a segmented packet of the RoHC packet.", "Here.", "the segmented packet may correspond to a configuration in which the RoHC packet, which is long, is divided into a plurality of segments, and one of the segments is included in the payload of the link layer packet.", "When the PC field has the value 1B, the PC field may be followed by a 1-bit last segment indicator (LI) field and a 3-bit segment ID field.", "In addition, to additionally provide information ahout segmentation, a segment sequence number field, a segment length ID field, a last segment length field, and the like may be additionally provided to the extended header.", "The LI field is a field used when the RoHC packet is segmented, the RoHC packet may be divided into a plurality of segments.", "When an LI has a value 1, a segment currently included in the link layer packet may be a last segment corresponding to one of the segments divided from one RoHC packet.", "When the LI has a value 0, a segment currently included in the link layer packet may not be the last segment.", "The LI field may be used to determine whether all the segments are received when the receiver collects the segments to re-combine one RoHC packet.", "The LI field may correspond to 1 bit.", "The segment ID (Seg_ID) field may be a field indicating an ID assigned to the RoHC packet when the RoHC packet is segmented.", "All segments derived from one RoHC packet may have segment IDs corresponding to the same value.", "When the receiver combines respective transmitted segments into one entity, it is possible to determine whether the segments correspond to elements of the same RoHC packet using the segment IDs.", "The segment ID field may correspond to 3 bits.", "Therefore, it is possible to simultaneously support segmentations of eight RoHC packets.", "The segment sequence number (Seg_SN) field may be a field used to verity an order of respective segments when the RoHC packet is segmented.", "That is, link layer packets having segments derived from one RoHC packet as payloads may have the same Seg_ID and have different Seg_SNs.", "Therefore, the one RoHC packet may be divided into a maximum of 16 segments.", "The segment length ID (Seg_Len_ID) field may be used to express a length of each of the segments.", "However, the segment length ID field may be used to express lengths of a plurality of segments except for the last segment.", "The length of the last segment may be indicated by the last segment length field to be described below.", "The segment length ID field may be present when the payload of the link layer packet does not correspond to the last segment of the RoHC packet, that is, the LI value 0.To reduce overhead of the header, a segment may have a length limited to 16.An input size of a packet may be determined based on a code rale of forward error correction (FEC) processed in a physical layer.", "The segment length may be determined based on the input size and be designated as a Seg_Len_ID.", "When the physical layer operates irrespective of the segment length, the segment length may be determined as below.", "Segment Length=Seg_Len_ID×Len_Unit+min_Len [bytes] [Math Figure 12] Here, Len_Unit (length Unit) is a basic unit for expression of the segment length, and min_Len may refer to a minimum value of the segment length.", "A transmitter and a receiver have the same values of Len_Unit and min_Len.", "It is efficient for a system operation when the values do not change after being determined.", "In addition.", "Len_Unit and min_Len may be determined based on an FEC processing ability of the physical layer in a system initialization process.", "Table 35 summarizes segment lengths expressed based on values of Seg-Len_ID.", "A length assigned to Seg-Len_ID corresponds to an example and thus the length may be changed according to intent of a designer.", "In this example, a Len_Unit value is 256, and a min_Len value is 512.TABLE 35 Seg_Len_ID Segment Length (Byte) 0000 512 (=min_Len) 0001 768 0010 1024 0011 1280 0100 1536 0101 1792 0110 2048 0111 2304 1000 2560 1001 2816 1010 3072 1011 3328 1100 3584 1101 3840 1110 4096 1111 4352 The last -segment length (L_Seg_Len) field is a field used when a segment included in the payload of the link layer packet is the last segment of the RoHC packet.", "That is, the last segment length field is a field used when the LI field has a value 1.The RoHC packet may be divided equally from the front part using Seg_Len_ID.", "In this case, the last segment may not have a size indicated by Seg_Len_ID.", "Therefore, the last segment may have a length direetiy indicated by the L_Seg_Len field.", "The L_Seg_Len field may indicate 1 to 4,095 bytes.", "This may be changed depending on an embodiment.", "FIG.", "76 illustrates Embodiment #1 of a method of transmitting an RoHC packet using a link layer packet, according to the present invention.", "The present embodiment corresponds to a case in which RoHC packets are within a processing range of a physical layer and thus one RoHC packet is included in a payload of the link layer packet.", "In this case, the RoHC packets are concatenated and may not be segmented.", "In this case, the one RoHC packet may become the pay-load of the link layer packet without change.", "A packet type may have a value 010B, a PC field may have a value 0B, and a CI field may have a value 0B.", "The above-described coum field may have a value 000B as described in the foregoing since the one RoHC packet forms the (one) payload without change.", "The count field may be followed by a 2-byte length field indicating a length of an RoHC packet.", "Only one packet is included in the payioad and thus a length part may include only one length field.", "In the present embodiment, a link layer header corresponding to 3 bytes in total may be additionally provided.", "Therefore, when the RoHC packet has a length of L bytes indicated by the length field, the link layer packet has a length of L+3 bytes in total.", "FIG.", "77 illustrates Embodiment #2 of a method of transmitting an RoHC packet using a link layer packet, according to the present invention.", "The present embodiment corresponds to a case in which RoHC packets are out of a processing range of a physical layer and thus one plurality of RoHC packets are concatenated and included in a payioad of the link layer packet.", "In this case, a PC field and a CI field have values corresponding to a case in which one RoHC packet is included in the payioad.", "The PC field and the CI field are followed by a count field.", "As described in the foregoing, the count field may have a value in a range of 001B to 111B depending on the number of RoHC packets included in the payioad.", "Thereafter, 2-byte length fields corresponding to the number indicated by the count field may be positioned.", "Each of the length fields may indicate a length of each of the RoHC packets.", "The length fields may be referred to as a length part.", "Here, when the number indicated by the count field is n. RoHC packets R1, R2 .", ".", ".", "and Rn having lengths L1, L2, .", ".", ".", "and Ln, respectively, may be concatenated in the payload of the link layer packet.", "An extended header may have a length of 2n bytes in total.", "A total length LT of the link layer packet may be expressed by the following liquation.", "L T = 1 + 2  n + ∑ k = 1 n   L k  [ bytes ] [ Math   Figure   13 ] FIG.", "78 illustrates Embodiment #3 of a method of transmitting an RoHC packet using a link layer packet, according to the present invention.", "The present embodiment corresponds to a case in which a plurality of RoHC packets are connected to each other (concatenated) to form a payload of the link layer packet, and the concatenated RoHC packets have the same CID.", "When the RoHC packets have the same CID, and a CID is indicated and transmitted once, a receiver may restore the RoHC packets and headers of the RoHC packets.", "Therefore, a CID common to the RoHC packets may be extracted and transmitted once.", "In this instance, overhead may be reduced.", "In this case, the above-described CI field has a value 1, which indicates that the same CID is processed.", "The RoHC packets having the same CID are indicated by [R1, R2, R3, .", ".", ".", "Rn].", "The CID common to the RoHC packets may be referred to as a common CID.", "A packet corresponding to an RoHC packet excluding a CID from a header is indicated by R′k(k is 1, 2, .", ".", ".", ", or n).", "The payload of the link layer packet may include R′k (k is 1, 2, .", ".", ".", ", or n).", "A common CID field may be additionally provided to a tail of an extended header of the link layer packet.", "The common CID field may be a field for transmission of the common CID.", "The common CID field may be transmitted as a portion of the extended header or as a portion of the payload of the link layer packet.", "Depending on a system operation, the common CID field may be appropriately rearranged at a portion for verification of a position.", "The common CID field may have a size varying according to a configuration of the RoHC packet.", "When the configuration of the RoHC packet corresponds to a small CID configuration, the RoHC packet may have a CID size of 4 bits.", "When rearrangement is performed by extracting a CID from the RoHC packet, the entire add-CID octet may be processed.", "That is, the common CID field may have a length of 1 byte.", "Alternatively, alter extracting a 1-byte add-CID octet from the RoHC packet, only a 4-bit CID may be assigned to the common CID field, and the remaining 4-bit CID may be reserved to be used later.", "When the configuration of the RoHC packet corresponds to a large CID configuration, the RoHC packet mav have a CID size of 1 byte or 2 bytes.", "The CID size is determined in an RoHC initialization process.", "Depending on the CID size, the common CID field may have a length of 1 byte or 1 bytes.", "In the present embodiment the payioad of the link layer packet may have a length calculated as below.", "Lengths of n RoHC packets R1, R2, .", ".", ".", ", and Rn having the same CID may be referred to as L1, L2, .", ".", ".", ", and Ln, respectively.", "When the header of the link layer packet has a length LH, the common CID field has a length LCID, and the link layer packet has an entire length LT, LH is as below.", "LH=1+2n+LCID bytes [Math Figure 14] In addition, LT may be calculated as below.", "L T = L H + ∑ k = 1 n   ( L k - L CID )   bytes [ Math   Figure   15 ] As described in the foregoing, LCID may be determined based on a CID configuration of the RoHC packet.", "That is, LCID may be 1 byte for the small CID configuration, and may be 1 byte or 2 bytes for the large CID configuration.", "FIG.", "79 illustrates Embodiment of a method of transmitting an RoHC packet using a link layer packet, according to the present invention.", "The present embodiment corresponds to a case in vU-ieh respective divided segments are compressed (encapsulated) into a payload of a link layer packet when an input RoHC packet b out of a processing range of a physical layer, A PC field has a value IB to report that the payload of the link laser packet includes a divided RoHC packet.", "An LI field has a value 1B only when a segment corresponding to a last portion of the RoHC packet is included as the payload, and has a value 0B for all the other segments.", "The LI field value reports information about an extended header of the link layer packet.", "That is, an extended header having a length of 1 byte may be additionally provided when the L1 field has a value 0B, and an extended header having a length of 2 bytes may be additionally provided when the LI field has a value 1B.", "All Seg_IDs have the some value to indicate segments divided front the same RoHC packet.", "Successively increasing Seg_SN values may be recorded in a header to indicate order information of segments for normal recombination of the RoHC packet in a receiver.", "When the RoHC packet is divided, segmentation may be performed by determining lengths of segments as described above.", "A value of a Seg_Len_ID matching a length may be recorded in the header.", "As described in the foregoing, a length of ft last segment may be directly recorded in an L_Seg_Len field having 12 bits.", "Length information indicated using the Seg_Len_ID and the L_Seg_Len field may indicate only information about a segment, that is, the payload of the link layer packet.", "Therefore, length information of the entire link layer packet may be obtained by adding a header length of the link layer packet which may be obtained using the LI field.", "In a process of recombiniug the segments of the RoHC packet at a receiving side, integrity of the recombined RoHC packet needs to be verified.", "In this end, cyclical redundancy check (CRC) may be additionally provided at a tail of an IP packet in a segmentation process.", "In general, CRC is additionally provided in a last part of the RoHC packet and thus CRC may be included in the last segment after the segmentation process.", "FIG.", "80 illustrates a header of a link layer packet for RoHC transmission according to an embodiment of the present invention when an MTU is 1,500.In general, an RoHC scheme may be applied during video and audio streaming.", "In this instance, an MTU of an IP packet may be set to 1,500 bytes, which indicates that an RoHC packet has a length less than 1,500 bytes.", "As described in the foregoing, a PC field of a fixed header may be a field that indicates a form in which an RoHC packet included in a payload of the link layer packet is processed, information about a remaining portion of the fixed header and an extended header following the PC field may be determined based on a value of the PC field.", "In addition, the PC field may include length information of the extended header based on the form in which the RoHC packet is processed.", "The PG field may have a size of 1 bit.", "A case in which the PC field has a value 0B will be described.", "The case in which the PC field has the value 0B corresponds to a case in which the payload of the link layer packet includes one RoHC packet or segmented packets of the RoHC packet.", "The PC field may be followed by an SI field.", "The SI field may indicate whether the payload of the link: Saver packet includes one RoHC packet or segments of the RoHC packet.", "The fixed header and the extended header may have fields determined based on a value of the SI field.", "As described in the foregoing, the SI field may be a field which indicates whether the payload of the link layer packet includes one RoHC packet or segments of the RoHC packet.", "The SI field having a value 0 may indicate that the payload of the link layer packet includes one RoHC packet, and the SI field having a value 1 may indicate that the payload of the link layer packet includes segments of the RoHC packet.", "The SI field may correspond to 1 byte.", "A Seg_ID field may be a field which indicates an ID assigned to the RoHC packet when the RoHC packet is segmented.", "This field is the same as the Seg_ID field described above.", "A Seg_SN field may be a field used to verify an order of respective segments when the RoHC packet is segmented.", "This field is the same as the Seg_SN field described above.", "An LI field may be a field which indicates whether a segment included in a current link layer packet is a last segment among segments divided from the RoHC packet when the RoHC packet is segmented.", "Thk ficki is the same as the LI field.", "A Seg_Len_ID field may be used to express lengths of respective segments.", "This field is the same as the Seg_Len_ID field described above.", "However, unlink the case described above, the segments may restricts vely have 8 lengths rather than 16 lengths.", "In this case, lengths of the segments expressed based on values of Seg_Len_ID may be summarized as Table 36 below.", "A length assigned to Seg_Len_ID is merely an example, and may be changed according to intent of a designer.", "In the present embodiment, a Len_Unit value is 64, and a min_Len value is 256.TABLE 36 Seg_Len_ID Segment Length (Byte) 0000 256 (=min_Len) 0001 320 0010 384 0011 448 100 512 101 576 110 640 111 704 An L_Seg_Len field may be used to express a length of the last segment.", "This field is the same as the L_Seg_Len field described above.", "However, unlink the case described above, the L_Seg_Len field may indicate 1 to 2,048 bytes.", "This may be changed according to an embodiment.", "A case in which the PC field has a value 1B will be described.", "The case in which the PC field has the value 1B corresponds to a case in which the payload of the link layer packet includes a concatenation of two or more RoHC packets.", "The PC field may be followed by a 1-bit CI field and a 3-bit count field.", "In this way, the extended header may be additionally provided with common CID information and a length part.", "The CI field is a field which indicates whether RoHC packets included in a payload of one link layer packet have the same CID.", "The CI field is as described above.", "The count field may indicate the number of RoHC packets included in the payload of the one link layer packet.", "Unlike the count field described above, a value 000 is assigned to indicate a concatenation of two RoHC packets.", "When the count field has a value 111, a concatenation of nine of more RoHC packets may be indicated.", "Count field values are summarized as the following Table 37.TABLE 37 Count No.", "of Concatenated RoHC packets (3 bits) (MTU = 1500 bytes) 000 2 001 3 010 4 011 5 100 6 101 7 110 8 111 9 or more packets, Extended length field is used The length part may be a part for indication of a length of the RoHC packet.", "The length part may include a plurality of length fields as described above.", "Each of the length fields may indicate a length of each RoHC packet.", "In the present embodiment, an MTU corresponds to 1,500 bytes and thus 11 bits corresponding to a minimum bit for indication of the MTU may be assigned to a length field.", "Since 11 bits may indicate up to 2,048 bytes, a scheme proposed in the present invention may be used even when the MTU is extended up to 2,048 bytes as necessary.", "The length field may directly indicate a length, and indicate the length by mapping the length to a separate value.", "As described in the foregoing, length fields corresponding to the number designated in the count field may be additionally provided, An extended length part may be used to indicate a length of a ninth RoHC packet or an RoHC packet after the ninth RoHC packet when nine of more RoHC packets are concatenated.", "That is, the extended length part may be used when the count field has a value 111B.", "The extended length part may include an 11-bit length field and a 1-bit X field.", "The two fields may be alternately positioned.", "A common CID field may be a field for transmission of a common CID.", "This field may be the same as the common CID field described above.", "FIG.", "81 illustrates Embodiment #1 of a method of transmitting an RoHC packet using a link layer packet when an MTU is 1,500 according to the present invention.", "The present embodiment may correspond to a case in which a PC field has a value 1 and a count field has a value other than 111B when the MTU is 1,500.In this case, a length part may have length fields corresponding to the number designated by a count field value as described above.", "Since one length field corresponds to 11 bits, a padding bit may be additionally provided depending on the number of the length fields.", "That is, when the number designated by the count field is set to k, and a size of the one length field is set to s (bits), a length LLP of the entire length part may be calculated as below.", "L LP = ⌈ k × s 8 ⌉  [ Bytes ] [ Math   Figure   16 ] In addition, a size of the padding bit additionally provided to the length part may be calculated as below.", "Lpadding=(8×LLP)−(k×s) [bits] [Math Figure 17] As described in the foregoing, the length s of the length field may be 11 bits, which may be used to summarize the sizes of the length part and the padding bit as below.", "TABLE 38 No.", "of Concatenated Count RoHC packets Size of Length Part Size of Padding (3 bits) (MTU = 1500 bytes) (Bytes) (bits) 000 2 3 2 001 3 5 7 010 4 6 4 011 5 7 1 100 6 9 6 101 7 10 3 110 8 11 1 FIG.", "82 illustrates Embodiment #2 of a method of transmitting an RoHC packet using a link layer packet when an MTU is 1,500 according to the present invention.", "The present embodiment may correspond to a case in which a PC field has a value 1 and a count field has a value 111B when the MTU is 1,500.In this case, an extended length part may be additionally provided as described above.", "A length part positioned in front of the extended length part includes eight 11-bit length fields and thus may have a length of 11 bytes in total.", "Since the count field has the value 111, the extended length part needs to include at least one length field.", "As described in the foregoing, the extended length part may include an 11-bit length field and a 1-bit X field.", "The two fields may be alternately positioned.", "The length field of the extended length part may be operated similarly to the length fields of the length part.", "The X field may be a field which indicates whether the X field is additionally followed by a length field.", "When the X field has a value 0, no length field may be additionally provided.", "When the X field has a value 1, the X field may be followed by at least one length field and an X field.", "Therefore, the extended length part may continuously increase until the X field has the value 0.RoHC packets equal in number to X fields may be additionally positioned in a payload.", "When the number of X fields having the value 1 is set to m and a size of one length field is set to s (bits) in the extended length part, a length LELP of the extended length part may be calculated as below.", "L ELP = ⌈ ( m + 1 ) × ( s + 1 ) 8 ⌉  [ Bytes ] [ Math   Figure   18 ] The extended length part may also have a padding bit for processing in bytes.", "The padding bit additionally provided in the extended length part may have a size calculated as below.", "Lbpadding=(8×LELP)−((m+1)×(s+1)) [Bits] [Math Figure 19] A padding bit of 4 bits may be additionally provided when the number of length fields is an odd number, and no padding bit may be additionally provided when the number of length fields is an even number.", "FIG.", "83 illustrates Embodiment #3 of a method of transmitting an RoHC packet using a link layer packet when an MTU is 1,500 according to the present invention.", "The present embodiment may correspond to a case in which RoHC packets are within a processing range of a physical layer and thus one RoHC packet is included in a payload of the link layer packet.", "In this case, the one RoHC packet may be the payload of the link layer packet without change.", "A pocket type may have a value 010B, a PC field may have a value 0B, and an SI field may have a value 0B.", "The above-described length part may follow the PC and SI fields.", "Here, the length part may have one length field.", "The length field may correspond to 11 bits.", "3 bits of a fixed header and 1 byte, of an extended header may be used for the one 11-bit length field.", "In this case, a link layer header having 2 bytes in total is additionally provided.", "Therefore, when the RoHC packet indicated by the length field has a length of L bytes, the link layer packet has a total length of L+2 bytes.", "FIG.", "84 illustrates fcmbodiment W of a method of transmitting an RoHC packet using a link layer packet when an MTU is 1,500 according to the present invention.", "The present embodiment may correspond to a case in which respective divided segments are compressed (encapsulated) into a payload of the link layer packet when the MTU is 1,500 and an input RoHC packet is out of a processing range of a physical layer.", "An SI field may have a value 1 to indicate segmentation.", "As described in the foregoing, Seg_IDs have the same value, and Seg_SNs have successively increasing values.", "An LI field has a value 1 for a last segment and has a value 0 otherwise.", "In addition.", "Seg_Len_ID and L_Seg_Len fields may be used to indicate a length of each segment.", "A detailed scheme of indicating a length may be similar to that described above.", "Length information of the entire link layer packet may be obtained by adding a header length of the link layer packet which may be obtained using the LI field.", "In addition, CRC may be additionally provided to verify integrity in a process of recombining the segments of the RoHC packet at a receiving side.", "The CRC may be additionally provided to the last segment.", "FIG.", "85 illustrates Embodiment #5 of a method of transmitting an RoHC packet using a link layer packet when an MTU is 1,500, according to the present invention.", "The present embodiment may correspond to a case In which RoHC packets are out of a processing range of a physical layer and thus a plurality of RoHC packets are concatenated and included in a payload of the link layer packet when the MTU is 1,500.The present embodiment may correspond to a case in which eight or less RoHC packets are concatenated.", "In this case, an extended length part may not be needed.", "A PC field may have a value 1, and a CI field may have a value 0.A count field may have a value in a range of 000B to 110B as described above.", "Here, when a value indicated by the count field is n, RoHC packets R1, R2, .", ".", ".", ", and Rn having lengths L1, L2, .", ".", ".", ", and Ln, respectively, may be concatenated in the payload of the link layer packet.", "Each length field may have a length of 11 bits.", "A padding bit may be positioned at a tail of the length field as necessary.", "A length LT of the entire link layer packet is as below.", "L T = 1 + L LP + ∑ k = 1 n   L k  [ bytes ] [ Math   Figure   20 ] Here, LLP may denote a length of the entire length part, and LK may denote a length of each RoHC packet.", "FIG.", "86 illustrates Embodiment #6 of a method of transmitting an RoHC packet using a link layer packet when an MTU is 1,500, according to the present invention.", "The present embodiment may correspond to a case in which RoHC packets are out of a processing range of a physical layer and thus a plurality of RoHC packets are concatenated and included in a payload of the link layer packet when the MTU is 1,500.However, the present embodiment may correspond to a case in which nine or more RoHC packets are concatenated.", "In this case, an extended length part may be needed in addition to a length part.", "As described in the foregoing, a count field may have a value 111.When the number of X fields, each of which has a value 1, is set to m in the extended length part, the number n of RoHC packets concatenated in the payload of the link layer packet is 8+(m+1).", "In this instance, a length LT of the entire link layer packet is as follows.", "L T = 1 + L LP + L BLP + ∑ k = 1 n   L k  [ bytes ] [ Math   Figure   21 ] Here, LLP may be a length of the entire length part and Lk may be a length of each of the RoHC packets.", "In addition, LELP may be a length of the entire extended length part.", "FIG.", "87 illustrates Embodiment #7 of a method of transmitting an RoHC packet using a link layer packet xvhen an MTU is 1,500, according to the present invention.", "The present embodiment may correspond to a case in which a plurality of RoHC packets are concatenated to form a payload of the link layer packet when the MTU is 1,500.However, the present embodiment corresponds to a case in which the concatenated RoHC packets have the same CID.", "In this case, the above-described CI field has a value 1, which indicates that the same CID is processed.", "The RoHC packets having the same CID are indicated by [R1, R2, R3, .", ".", ".", ", Rn].", "The CID common to the RoHC packets may be referred to as a common CID.", "A packet corresponding to an RoHC packet exeiuding a CID from a header is indicated by R′k(k is 1, 2, .", ".", ".", "or n).", "The payload of the link layer packet may include R′k (k is 1, 2, .", ".", ".", ", or n).", "A common CID field may be additionally provided to a tail of an extended header of the link layer packet.", "The common CID field may be a field for transmission of the common CID.", "The common CID field may be transmitted as a portion of the extended leader or as a portion of the payload of the link layer packet.", "Depending on a system operation, the common CID field may be appropriately rearranged at a portion for verification of a position.", "The common CID field may have a size varying according to a configuration of the RoHC packet.", "When the configuration of the RoHC packet corresponds to a small CID configuration, the RoHC packet may have CID size of 4 bits.", "When rearrangement is performed by extracting a CID from the RoHC packet, the entire add-CID octet may be processed.", "That is, the common CID field may have a length of 1 byte.", "Alternatively, alter extracting a 1-byte add-CID octet from the RoHC packet, only a 4-bit CID may be assigned to the common CID field, and the remaining 4-bit CID may be reserved for later use.", "When the configuration of the RoHC packet corresponds to a large CID configuration, the RoHC packet may have a CID size of 1 byte or 2 bytes.", "The CID size is determined in an RoHC initialization process.", "Depending on the CID size, the common CID field may have a length of 1 byte or 2 bytes.", "In this case, the entire length LT of the link layer packet may be calculated as below.", "L T = 1 + L LP + L CID + ∑ k = 1 n   ( L k - L CID )  [ bytes ] [ Math   Figure   22 ] Here, LCID may denote a length of the common CID field.", "As described in the foregoing, LCID may be determined based on a CID configuration of the RoHC packet.", "Similarly, when n is greater than or equal to 9 (the count field has a value 111B), the entire length LT of the link layer packet may be calculated as below.", "L T = 1 + L LP + L ELP + L CID + ∑ k = 1 n   ( L k - L CID )  [ bytes ] [ Math   Figure   23 ] Here, LCID may denote a length of the common CID field.", "FIG.", "88 illustrates a protocol stack for a hybrid-based next generation broadcast system according to another embodiment of the present invention.", "In a hybrid-based broadcast system of a TS and an IP stream, a link layer may be used to transmit data having a TS or IP stream type.", "When various types of data are to be transmitted through a physical layer, the link layer may convert the data into a format supported by the physical layer and deliver the converted data to the physical layer.", "In this way, the various types of data may be transmitted through the same physical layer.", "Here, the physical layer may correspond to a step of transmitting data using an MIMO/MISO scheme or the like by interleaving, multiplexing, and/or modulating the data.", "The link layer needs to be designed such that an influence on an operation of the link layer is minimized even when a configuration of the physical layer is changed.", "In other words, the operation of the link layer needs to be configured such that the operation may be compatible with various physical layers.", "The present invention proposes a link layer capable of independently operating irrespective of types of an upper layer and a lower layer.", "In this way, it is possible to support various upper layers and lower layers.", "Here, the upper layer may refer to a layer of a data stream such as a TS stream, an IP stream, or the like.", "Here, the lower layer may refer to the physical layer.", "In addition, the prese.nl invention proposes a link layer having a correctable structure in which a function supportable by the link layer may be extended/added/deleted.", "Moreover, the present invention proposes a scheme of including an overhead reduction function in the link layer such that radio resources may be efficiently used.", "In this figure, protocols and layers such as IP, UDP, TCP.", "ALC/LCT, RCP/RTCP, HTTP, FLUTE, and the like are as described above.", "In this figure, a link layer t88010 may be another example of the above-described data link (encapsulation) part.", "The present invention proposes a configuration and/or an operation of the link layer t8800.The link layer t88010 proposed by the present invention may process signaling necessary for operations of the link layer and/or the physical layer.", "In addition, the link layer t88010 proposed by the present invention may encapsulate TS and IP packets and the like, and perform overhead reduction in this process.", "The link layer t88010 proposed by the present invention may be referred to by several terms such as data link layer, encapsulation layer, layer 2, and the like.", "According to a given embodiment, a new term may be applied to ihc link layer and used.", "FIG.", "89 illustrates an operation in a normal mode corresponding to one of operation modes of a link layer according to an embodiment of the present invention.", "The link layer proposed by the present invention may have various operation modes for compatibility between an upper layer and a lower layer.", "The present invention proposes a normal mode and a transparent mode of the link layer.", "Both the operation modes may coexist in the link layer, and an operation mode to be used may be designated using signaling or a system parameter.", "According to a given embodiment, one of the two operaiion modes may be implemented.", "Different modes may be applied according to an IP layer, a TS layer, and the like input to the link layer.", "In addition, different modes may be applied for each stream of the IP layer and for each stream of the TS layer.", "According to a given embodiment, a new operation mode may be added to the link layer.", "The new operation mode may be added based on configuration of the upper layer and the lower layer.", "The new operation mode may include different interfaces based on the configurations of the upper layer and the lower layer.", "Whether to use the new operation mode may be designated using signaling or a system parameter.", "In the normal mode, data may be processed through all functions supported by the link layer, and then delivered to a physical layer.", "First, each packet may be delivered to the link layer from an IP layer, an MPEG-2 TS layer, or another particular layer t89010.In other words, an IP packet may be delivered to the link layer from an IP layer.", "Similarly, an MPEG-2 TS packet may be delivered to the link layer from the MPEG-2 TS layer, and a particular packet may be delivered to the link layer from a particular protocol layer.", "Each of the delivered packets may go through or not go through an overhead reduction process t89020, and then go through an encapsulation process t89030.First, the IP packet may go through or not go through the overhead reduction process t89020, and then go through the encapsulation process t89030.Whether the overhead reduction process t89020 is performed may be designated by signaling or a system parameter.", "According to a given embodiment, the overhead reduction process t89020 may be performed or not performed for each IP stream.", "An encapsulated IP packet may be delivered to the physical layer.", "Second, the MPEG-2 TS packet may go through the overhead reduction process t89020, and go through the encapsulation process t89030.The MPEG-2 TS packet may not be subjected to the overhead reduction process t89020 according to a given embodiment.", "However, in general, a TS packet has sync bytes (0x47) and the like at the front and thus it may be efficient to eliminate such fixed overhead.", "The encapsulated TS packet may be delivered to the physical layer.", "Third, a packet other than the IP or TS packet may or may not go through the overhead reduction process t89020, and then go through the encapsulation process t89030.Whether or not the overhead reduction process t89020 is performed may be determined according to characteristics of the corresponding packet.", "Whether the overhead reduction process t89020 is performed may be designated by signaling or a system parameter.", "The encapsulated packet may be delivered to the physical layer.", "In the overhead reduction process t89020, a size of an input packet may be reduced through an appropriate scheme.", "In the overhead reduction process t89020, particular information may be extracted from the input packet or generated.", "The particular information is information related to signaling, and may be transmitted through a signaling region.", "The signaling information enables a receiver to restore an original packet by restoring changes due to the overhead reduction process t89020.The signaling information may be delivered to a link layer signaling process t89050.The link layer signaling process t89050 may transmit and manage the signaling information extracted/generated in the overhead reduction process t89020.The physical layer may have physically/logically divided transmission paths for signaling, and the link layer signaling process t89050 may deliver the signaling information to the physical layer according to the divided transmission paths.", "Here, the above-described FIC signaling process t89060.EAS signaling process t89070, or the like may be included in the divided transmission paths.", "Signaling information not transmitted through the divided transmission paths may be delivered to the physical layer through the encapsulation process t89030.Signaling information managed by the link layer signaling process t89050 may include signaling information delivered from the upper layer, signaling information generated in the link layer, a system parameter, and the like.", "Specifically, the signaling information may include signaling information delivered from the upper layer to be subsequently delivered to an tipper layer of the receiver, signaling information generated in the link layer to be used for an operation of a link layer of the receiver, signaling information generated in the upper layer or the link layer to be used for rapid detection in a physical layer of the receiver, and the like.", "Data going through the encapsulation process t89030 and delivered to the physical layer may be transmitted through a data pipe (DP) t89040.Here, the DP may be a physical layer pipe (PLP).", "Signaling information delivered through the above-described divided transmission paths may be delivered through respective transmission paths.", "For example, an FIC signal may be transmitted through an FIC t89080 designated in a physical frame.", "In addition, an EAS signal may be transmitted through an EAC t89090 designated in a physical frame.", "Information about presence of a dedicated channel such as the FIC, the EAC, or the like may be transmitted to a preamble area of the physical layer through signaling, or signaled by scrambling a preamble using a particular scrambling sequence.", "According to a given embodiment.", "FIC signaling/EAS signaling information may be transmitted through a general DP area.", "PLS area, or preamble rather than a designated dedicated channel.", "The receiver may receive data and signaling information through the physical layer.", "The receiver may restore the received dam and signaling information into a form processable in the upper layer, and deliver the restored data and signaling information to the upper layer.", "This process may be performed in the link layer of the receiver.", "The receiver may verify whether a received packet is related to the signaling information or the data by reading a header of the packet and the like.", "In addition, when overhead reduction is performed at a transmitter, the receiver may restore a packet, overhead of which has been reduced through the overhead reduction process, to an original packet.", "In this process, the received signaling information may be used.", "FIG.", "90 illustrates an operation in a transparent mode corresponding to one of operation modes of a link layer according to an embodiment of the present invention.", "In the transparent mode, data may not be subjected to functions supported by the link layer or may be subjected to some of the functions, and then delivered to a physical layer.", "In other words, in the transparent mode, a packet delivered to an upper layer may be delivered to a physical layer without going through a separate overhead reduction and/or encapsulation process.", "Other packets may go through the overhead reduction and/or encapsulation process as necessary.", "The transparent mode may be referred to as a bypass mode, and another term may be applied to the transparent mode.", "According to a given embodiment, some packets may be processed in the normal mode and some packets may be processed in the transparent mode based on characteristics of the packets and a system operation.", "A packet to which tbe transparent mode may be applied may be a packet having a type well known to a system.", "When the packet may be processed in the physical layer, the transparent mode may be used.", "For example, a well-known TS or IP packet may go through separate overhead reduction and input formatting processes in the physical layer and thus the transparent mode may be used in a link layer step.", "When the transparent mode is applied and a packet is processed through input formatting and the like in the physical layer, an operation such as the above-described TS header compression may be performed in the physical layer.", "On the other hand, when the normal mode is applied, a processed link layer packet may be treated as a GS packet and processed in the physical layer.", "In the transparent mode, a link layer signaling module may be included when signal transmission needs to be supported.", "As described above, the link layer signaling module may transmit and manage signaling information.", "The signaling information may be encapsulated and transmitted through a DP, and FIC signaling information and EAS signaling information having divided transmission paths may be transmitted through an FIC and an EAC, respectively.", "In the transparent mode, whether information corresponds to signaling information may be displayed using a fixed IP address and port number.", "In this case, the signaling information may be filtered to configure a link layer packet, and then transmitted through the physical layer.", "FIG.", "91 illustrates a configuration of a link layer at a transmitter according to an embodiment of the present invention (normal mode).", "The present embodiment is an embodiment presuming that an IP packet is processed.", "The link layer at the transmitter may largely include a link layer signaling part for processing signaling information, an overhead reduction part, and/or an encapsulation part from a functional perspective.", "The link layer at the transmitter may further include a scheduler t91020 for a control of the entire operation of the link layer and scheduling, input and output parts of the link layer, and/or the like.", "First, upper layer signaling information and/or system parameter t91010 may be delivered to the link layer.", "In addition, an IP stream including IP packets may be delivered to the link layer from an IP layer t91110.As described above, the scheduler t91020 may determine and control operations of several modules included in the link layer.", "The delivered signaling information and/or system parameter t91010 may be filtered or used by the scheduler t91020.Information corresponding to a part of the delivered signaling information and/or system parameter t91010 and necessary for a receiver may be delivered to the link layer signaling part.", "In addition, information corresponding to a part of the signaling information and necessary for an operation of the link layer may be delivered to an overhead reduction control block t91120 or an encapsulation control block t91180.The link layer signaling part may collect information to be transmitted as signaling in the physical layer, and transform/configure the information in a form suitable for transmission.", "The link layer signaling part may include a signaling manager t91030, a signaling formatter t91040, and/or a buffer for channels t91050.The signaling manager t91030 may receive signaling information delivered from the scheduler t91020, signaling delivered from the overhead reduction pari, and/or context information.", "The signaling manager t91030 may determine paths for transmission of the signaling information with respect to delivered data.", "The signaling information may be delivered through the paths determined by the signaling manager t91030.As described in the foregoing, signaling information to be transmitted through divided channels such as an FIC, an EAS, and the like may be delivered to the signaling formatter t91040, and other signaling information may be delivered to an encapsulation buffer t91070.The signaling formatter t91040 may format associated signaling information in forms suitable for respective divided channels so that the signaling information may be transmitted through separately divided channels.", "As described in the foregoing, the physical layer may include physically/logically divided separate channels.", "The divided channels may be used to transmit FIC signaling information or EAS-related information.", "The FIC or EAS-related information may be divided by the signaling manager t91030 and input to the signaling formatter t91040.The signaling formatter t91040 may format information such that the information is suitable for respective separate channels.", "Besides the FIC and the EAS, when the physical layer is designed to transmit particular signaling information through separately divided channels, a signaling formatter for the particular signaling information may be added.", "Through this scheme, the link layer may be compatible with various physical layers.", "The buffer for channels t91050 may deliver signaling information delivered from the signaling formatter t91040 to designated dedicated channels t91060.The number and content of the dedicated channels t91060 may vary depending on an embodiment.", "As described in the foregoing, the signaling manager t91030 may deliver signaling information which is not delivered to a dedicated channel to the encapsulation buffer t91070.The encapsulation buffer t91070 may function as a butler that receives the signaling information not delivered to the dedicated channel.", "An encapsulation for signaling information t91080 may encapsulate the signaling information not delivered to the dedicated channel.", "A transmission butler t91090 may0 function as a buffer that delivers the encapsulated signaling information to a DP for signaling information t91100.Here, the DP for signaling information t91100 may refer to the above-described PLS area.", "The overhead reduction part may allow efficient transmission by eliminating overhead of packets delivered to the link layer.", "It is possible to configure overhead reduction parts, the number of which is the same as the number of IP streams input to the link layer.", "An overhead reduction buffer t91130 may receive an IP packet delivered from an upper layer.", "Hie delivered IP packet may be input to the overhead reduction part through the overhead reduction buffer t91130.An overhead reduction control block t91120 may determine whether to perform overhead reduction on a packet stream input to the overhead reduction butler t91130.The overhead reduction control block t91120 may determine whether to perform overhead reduction for each packet stream.", "When overhead reduction is performed on the packet stream, packets may be delivered to an RoHC compressor t91140 and overhead reduction may be performed.", "When overhead reduction is not performed on the packet stream, packets may be delivered to the encapsulation part and encapsulation may be performed without overhead reduction.", "Whether to perform overhead reduction on packets may be determined by signaling information t91010 delivered to the link layer.", "The signaling information t91010 may be delivered to the encapsulation control block t91180 by the scheduler t91020.The RoHC compressor t91140 may perform overhead reduction on a packet stream.", "The RoHC compressor t91140 may compress headers of packets.", "Various schemes may be used for overhead reduction.", "Overhead reduction may be performed by schemes proposed in the present invention.", "The present embodiment presumes an IP stream and thus the compressor is expressed as the RoHC compressor.", "However, the term may be changed according to a given embodiment.", "In addition, an operation is not restricted to compression of an IP stream, and overhead reduction may be performed on all types of packets by the RoHC compressor t91140.A packet stream configuration block t91150 may divide IP packets having compressed headers into information to be transmitted to a signaling region and information to be transmitted to a packet stream, the information to be transmitted to the packet stream may refer to information to be transmitted to a DP area.", "The information to be transmitted to the signaling region may be delivered to a signaling and/or context control block t91160.The information to be transmitted to the packet stream may be transmitted to the encapsulation part.", "The signaling and/or context control block t91160 may collect signaling and/or context information and deliver the collected information to the signaling manager t91030.In this way, the signaling and/or context information may be transmitted to the signaling region.", "The encapsulation part may encapsulate packets in suitable forms such that the packets may be delivered to the physical layer.", "The number of configured encapsulation parts may be the same as the number of IP streams.", "An encapsulation buffer t91170 may receive a packet stream for encapsulation.", "Packets subjected to overhead reduction may be received when overhead reduction is performed, and an input IP packet may be received without change when overhead reduction is not performed.", "An encapsulation control block t91180 may determine whether to perform encapsulation on an input packet stream When encapsulation is performed, the packet stream may be delivered to segmentation/concatenation t91190.When encapsulation is not performed, the packet stream may be delivered to a transmission butler t91230.Whether to perform encapsulation of packets may be determined based on the signaling information t91010 delivered to the link layer.", "The signaling information t91010 may be delivered to the encapsulation control block t91180 by the scheduler t91020.In the segmentation/concatenation t91190, the above-descried segmentation or concatenation operation may be performed on packets.", "In other words, when an input IP packet is longer than a link layer packet corresponding to an output of the link layer, one IP packet may be divided into several segments to configure a plurality of link layer packet payloads.", "In addition, when the input IP packet is shorter than the link layer packet corresponding to the output of the link layer, several IP packets may be combined to configure one link layer packet payload.", "A packet configuration table t91200 may have information about a configuration of segmented and or concatenated link layer packets.", "A transmitter and a receiver may have the same information of the packet configuration table t91200.The transmitter and the receiver may refer to the information of the packet configuration table t91200.An index value of the information of the packet configuration table t91200 may be included in headers of the link layer packets.", "A link layer header information block t91210 may collect header information generated in an encapsulation process.", "In addition, the link layer header information block t91210 may collect information included in the packet configuration table t91200.The link layer header information block t91210 may configure header information according to a header configuration of a link layer packet.", "A header attachment block t91220 may add headers to payloads of the segmented and or concatenated Itnk layer pockets.", "The transmission buffer t91230 may function as a buffer for delivering a link layer packet to a DP t91240 of the physical layer.", "Each block or module and parts may be configured as one module/protocol or a plurality of modules/protocols in the link layer.", "FIG.", "92 illustrates a configuration of a link layer at a receiver according to an embodiment of the present invention (normal mode).", "The present embodiment is an embodiment presuming that an IP packet is processed.", "The link layer at the receiver may largely include a link layer signaling part for processing signaling information, an overhead processing part, and/or a decapsulation part from a functional perspective.", "The link layer at the receiver may further include a scheduler for a control of the entire operation of the link layer and scheduling, input and output parts of the link layer, and/or the like.", "First information received through a physical layer may be delivered to the link layer.", "The link layer may process the information to restore the information to an original state in which the information in not yet processed by a transmitter, and deliver the information to an upper layer In the present embodiment, the upper layer may be an IP layer.", "Information delivered through dedicated channels t92030 separated from the physical layer may be delivered to the link laser signaling part.", "The link layer signaling part may distinguish signaling information received from the physical layer, and deliver the distinguished signaling information to each part of the link layer.", "A buffer for channels t92040 may function as a buffer that receives signaling information transmitted through the dedicated channels.", "At described above, when physically/logically divided separate channels are present in the physical layer, it is possible to receive signaling information transmitted through the channels.", "When the information received from the separate channels is in a divided state, the divided information may be stored until the information is in a complete form.", "A signaling decoder/purser t92050 may check a format of signaling information received through a dedicated channel, and extract information to be used in the link layer.", "When the signaling information received through the dedicated channel is encoded, decoding may be performed.", "In addition, according to a given embodiment, it is possible to check integrity of the signaling information.", "A signaling manager t92060 may integrate signaling information received through several paths.", "Signaling information received through a DP for signaling t92070 to be described below may be integrated by the signaling manager t92060.The signaling manager t92060 may deliver signaling information necessary for each part in the link layer.", "For example, context information for recovery of a packet and the like may be delivered to the overhead processing part.", "In addition, signaling information for control may be delivered to a scheduler t92020.General signaling information not received through a separate dedicated channel may be received through the DP for signaling t92070.Here, the DP for signaling may refer to a PLS or the like.", "A reception buffer t92080 may function as a buffer for receiving the signaling information received from the DP for signaling t92070.The received signaling information may be decapsulated in a decapsulation for signaling information block t92090.The decapsulated signaling information may be delivered to the signaling manager t92060 through a decapsulation buffer t92100.As described in the foregoing, the signaling manager t92060 may collect signaling information and deliver the collected signaling information to a desired part in the link layer.", "The scheduler t92020 may deiermine and control operations of several modules included in the link layer.", "The scheduler t92020 may control each part of the link layer using receiver information t92010 and/or information delivered from the signaling manager t92060.In addition, the scheduler t92020 may determine an operation mode and the like of each part.", "Here, the receiver information t92010 may refer to information previously stored by the receiver.", "The scheduler t92020 may use information changed by a user such as a channel change and the like for control.", "The decapsulation part may titter a packet received from a DP t92110 of the physical layer, and separate the packet based on a type of the packet.", "The number of configured decapsulation parts may be the same as the number of DPs that may be simultaneously decoded in the physical layer.", "A decapsulation buffer t92120 may function as a buffer that receives a packet stream from the physical layer to perform decapsulation.", "A decapsulation control block t92130 may determine whether to dccapsulatc the received packet stream.", "When decapsulation is performed, the packet stream may be delivered to a link layer header parser t92140.When decapsulation is not performed, the packet stream may be delivered to an output buffer t92220.The signaling information delivered from the scheduler t92020 may be used to determine whether to perform decapsulation.", "The link layer header parser t92140 may identify a header of a received link layer packet.", "When the header is identified, it is possible to identify a configuration of an IP packet included in a payload of the link layer packet.", "For example, the IP packet may be segmented or concatenated.", "A packet configuration table t92150 may include payload information of link layer packets configured through segmentation and/or concatenation.", "The transmitter and the receiver may have the same information as information of the packet configuration table t92150.The transmitter and the receiver may refer to the information of the packet configuration table t92150.A value necessary for reassembly may be found based on index information included in the link layer packets.", "A reassembly block t92160 may configure payloads of the link layer packets configured through segmentation and/or concatenation as packets of an original IP stream.", "The reassembly block t93160 may reconfigure one IP packet by collecting segments, or reconfigure a plurality of IP packet streams by separating concatenated packets.", "The reassembled IP packets may be delivered to the overhead processing part.", "The overhead processing pari may perform a reverse process of overhead reduction performed by the transmitter.", "In the reverse process, an operation of returning packets experiencing overhead reduction to original packets is performed.", "This operation may be referred to as overhead processing.", "The number of configured overhead processing parts may be the same as the number of DPs that may be simultaneously decoded in the physical layer.", "A packet recovery buffer t9210 may function as a buficr that receives an RoHC packet or an IP packet decapstilated for overhead processing.", "An overhead control block t92180 may determine whether to perform packet recovery and/or decompression of encapsulated packets.", "When the packet recovery and/or decompression are performed, the packets may be delivered to a packet stream recovery t92190.When the packet recovery and/or decompression are not performed, the packets may be delivered to the output buffer t92220.Whether to perform the packet recovery and/or decompression may be determined based on the signaling information delivered by the scheduler t92020.The packet stream recovery t92190 may perform an operation of integrating a packet stream separated from the transmitter and context information of the packet stream.", "The operation may correspond to a process of restoring the packet stream such that the packet stream may be processed by an RoHC decompressor t92210.In this process, signaling information and/or context information may be delivered from a signaling and/or context control block t92200.The signaling and/or context control block t92200 may distinguish signaling information delivered from the transmitter and deliver the signaling information to the packet stream recovery t92190 such that the signaling information may be mapped to a stream suitable for a context ID.", "The RoHC decompressor t92210 may recover headers of packets of a packet stream.", "When the headers are recovered, the packets of the packet stream may be restored to original IP packets.", "In other words, the RoHC decompressor t92210 may perform overhead processing.", "The output buffer t93220 may function as a buffer before delivering an output stream to an IP layer t92230.The link layer of the transmitter and the receiver proposed in the present invention may include the blocks or modules described above.", "In this way, the link layer may independently operate irrespective of the upper layer and the lower layer, and efficiently perform overhead reduction.", "In addition, a function which is supportable depending on the upper and lower layers may be easily extended/added/deleted.", "FIG.", "93 illustrates a method of transmitting broadcast signals according to an embodiment of the present invention.", "The method includes generating plural input streams, link layer processing the input packets, physical layer processing the link layer packets and/or transmitting the generated broadcast signals.", "In step of generating plural input streams, the input streams including plural input packets can be generated in upper layer.", "Upper layer can be either TS layer, IP layer or other types of packet layer.", "Therefore, the input packets can be either TS packets, IP packets or other packets.", "Input stream includes consecutive input packets.", "In step of link layer processing the input packets, the input packets can be processed by the link layer described above.", "The link layer can be the one suggested by the present invention.", "By processing input packets in the link layer, the link layer packets can be generated.", "By processing any types of input packets into the link layer packet, any input streams can be processed by the physical layer.", "In step of physical layer processing the link layer packets, the link layer packets can be processed in physical layer.", "The link layer packets can go through interleaving, frame mapping, and/or modulating and so on.", "With this process, the broadcast signals can be generated.", "In step of transmitting the generated broadcast signals, the broadcast signals can be transmitted by either SISO, MISO, or MIMO.", "The transmitting can be included in physical layer.", "In a method of transmitting broadcast signals according to other embodiment of the present invention, the link layer processing includes link layer processing one of the plural input streams based on transparent mode.", "As described above, there can be two modes for link layer processing, normal and transparent.", "In link layer processing, some of input streams can be processed in transparent mode, while the others are processed in normal mode.", "In transparent mode, the link layer delivers the one of the plural input streams to the physical layer without encapsulating.", "Signaling information supposed to be transmitted in a dedicated channel, can be delivered to that channel in the physical layer.", "Some types of packets can go through encapsulating, even in the transparent mode, as described above.", "In a method of transmitting broadcast signals according to another embodiment of the present invention, the link layer processing in normal mode includes encapsulating and/or delivering.", "The link layer processing one of the plural input streams includes encapsulating the input packets in the one of the plural input streams to generate the link layer packets.", "The generated link layer packets can be delivered to the physical byer.", "In a method of transmitting broadcast signals according o another embodiment of the present invention, the link layer processing in normal mode includes overhead reduction processing the input packets before encapsulating.", "The overhead reduction process can be conducted after the encapsulating in other embodiments.", "The overhead reduction process can include compress headers of the input packets.", "Other method of overhead reduction can be used in link layer.", "In a method of transmitting broadcast signals according to another embodiment of the present invention, the link byer processing in normal mode includes extracting a first signaling information and/or delivering.", "The first signaling information can be extracted from overhead reduction processed input packets.", "The first signaling information is a signaling information to be transmitted in a dedicated transmission channel.", "The above described EAS.", "FIC information can correspond to the first signaling information.", "The first signaling information can be delivered to the dedicated channel for the first signaling information, in the physical layer.", "In a method of transmitting broadcast signals according to another embodiment of the present invention, the link layer processing in normal mode includes extracting a second signaling information, encapsulating the second signaling information and/or delivering.", "The second signaling information is for signaling data in the input packets.", "The second signaling information can be encapsulated as in the encapsulation of input packets.", "The second signaling information can be encapsulated into the link layer packets.", "The link layer packet generated by using the second signaling information can be delivered to the physical layer.", "The second signaling information can be transmitted in DP or PLS, as described above.", "In a method of transmitting broadcast signals according to another embodiment of the present invention, the link layer packet includes a link layer payload generated by using a segment of one of the inpm packets, or by using concatenated input packets.", "As described above, the link layer payload can be encapsulated by segmentation or concatenation.", "Various methods of segmentation and concatenation have been described.", "Segmentation and concatenation methods for each types of input packets can be used in encapsulation.", "Whether the segmentation or the eoncatenation is u.sed can be decided based on signaling information.", "In a method of transmitting broadcast signals according to another embodiment of the present invention, the physical layer processing includes physical layer processing plural Plops (Physical Layer Pipes).", "The PLP may correspond to the DP.", "The PLP can include data of the link layer packets, and be processed in physical layer.", "The link layer can be processed in physical layer as in forms of Plops.", "In a method of transmitting broadcast signals according to another embodiment of the present invention, the physical layer processing includes physical layer processing the first signaling information.", "The first signaling information can be processed into the dedicated transmission channel, to generate the broadcast signals.", "In a method of transmitting broadcast signals according to another embodiment of the present invention, the input packets are one of TS(Transport Stream) packet, IP(Internet Protocol) packet or GS(Gencric Stream) packet.", "The input packets can be some types of packets other than TS, IP or OS packets.", "The above-described steps can be omitted or replaced by steps executing similar or identical functions according to design.", "A module or a unit is a processor executing a sequence of instructions stored in a memory (or storage unit).", "The steps in above described embodiments can be operated in hardware/processors.", "The first module, second module, third module and/or fourth module can be operated as hardware/processors.", "In addition, a method of transmitting broadcast signals according to an embodiment of the present invention may be implemented as code that may be written on a processor readable recording medium and thus, read by a processor provided in the apparatus.", "Although the description of the present invention is explained with reference to each of the accompanying drawings for clarity, it is possible to design new embodiments) by merging the embodiments shown in the accompanying drawings with each other.", "And, if a recording medium readable by a computer, in which programs for executing the embodiments mentioned in the foregoing description are recorded, is designed in necessity of those skilled in the art, it may belong to the scope of the appended claims and their equivalents.", "An apparatus and method according to the present invention may be non-limited by the configurations and methods of the embodiments mentioned in the foregoing description.", "And, the embodiments mentioned in the foregoing description can be configured in a manner of being selectively combined with one another entirety or in part to enable various modifications.", "In addition, a method according to the present invention can be implemented with processor-readable codes in a processor-readable recording medium provided to a network device.", "The processor-readable medium may include all kinds of recording devices capable of storing data readable by a processor.", "The processor-readable medium may include one of ROM, RAM, CD-ROM, magnetic tapes, floppy discs, optical data storage devices, and the like for example and also include such a carrier-wave type implementation as a transmission via Internet.", "Furthermore, as the processor-readable recording medium is distributed to a computer system connected via network, processor-readable codes can be saved and executed according to a distributive system.", "It will be appreciated by those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the inventions.", "Thus, it is intended that the present invention covers the modifications and variations of this invention provided they come within the scope of the appended claims and their equivalents.", "Both apparatus and method inventions are mentioned in this specification and descriptions of both of the apparatus and method inventions may be complementarity applicable to each other.", "Various embodiments have been described in the best mode for carrying out the invention.", "The present invention is available in a series of broadcast signal provision fields.", "It will be apparent to those skilled tn the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the inventions.", "Thus, it is intended that the present invention covers the modifications and variations of this invention provided they come within the scope of the appended claims and their equivalents." ] ]
Patent_15875910
[ [ "POLYPROPYLENE RESIN FOAMED PARTICLES, METHOD FOR PRODUCING POLYPROPYLENE RESIN FOAMED PARTICLES, METHOD FOR PRODUCING POLYPROPYLENE RESIN IN-MOLD FOAM-MOLDED ARTICLE, AND POLYPROPYLENE RESIN IN-MOLD FOAM-MOLDED ARTICLE", "An expanded polypropylene resin particle includes a polypropylene resin (X) as a base resin, the polypropylene resin (X) containing a polypropylene resin (I) and a high density polyethylene resin (II).", "The polypropylene resin (I) has a melting point of 145 to 165° C., and the high density polyethylene resin (II) has a density of 0.93 to 0.97 g/cm3.", "The polypropylene resin (X) contains no or one foam nucleating agent." ], [ "1.An expanded polypropylene resin particle comprising: a polypropylene resin (X) as a base resin; no or only one foam nucleating agent; and a hydrophilic compound, wherein the polypropylene resin (X) comprises: 85 to 99 weight % of a polypropylene resin (I); and 1 to 15 weight % of a high density polyethylene resin (II), a total amount of the polypropylene resin (I) and the high density polyethylene resin (II) being 100 weight %, wherein the polypropylene resin (I) has a melt flow rate of 3 to 20 g/10 min.", "and a melting point of 145 to 165° C., wherein the high density polyethylene resin (II) has a density of 0.93 to 0.97 g/cm3 and a melt flow rate of 0.1 to 15 g/10 min., and wherein the expanded polypropylene resin particle has an expansion ratio ranging from 10 to 40 times, an average cell diameter of 100 to 250 μm, and an open cell ratio ranging from 0 to 10%.", "2.The expanded polypropylene resin particle according to claim 1, wherein the melting point of the polypropylene resin (I) is 148 to 160° C. 3.The expanded polypropylene resin particle according to claim 1, wherein a melting point of the high density polyethylene resin (II) is 125 to 135° C. 4.The expanded polypropylene resin particle according to claim 1, wherein a melting point of the high density polyethylene resin (II) is 125 to 130° C. 5.The expanded polypropylene resin particle according to claim 1, wherein the high density polyethylene resin (II) has a flexural modulus of 800 to 1600 MPa.", "6.The expanded polypropylene resin particle according to claim 1, wherein an amount of the foam nucleating agent is 0.005 to 2 parts by weight with respect to 100 parts by weight of the polypropylene resin (X).", "7.The expanded polypropylene resin particle according to claim 1, wherein the hydrophilic compound is at least one selected from the group consisting of melamine, glycerin, diglycerin, and polyethylene glycol.", "8.A method for producing expanded polypropylene resin particles containing a polypropylene resin (X) as a base resin, the method comprising: obtaining a dispersion slurry by placing water, an inorganic gas-based foaming agent, and polypropylene resin particles composed of the polypropylene resin (X) in a pressure-resistant container; dispersing the polypropylene resin particles with stirring; increasing a temperature and a pressure; and releasing the dispersion slurry from the pressure-resistant container to a region having a pressure lower than an internal pressure of the pressure-resistant container to expand the polypropylene resin particles, wherein the polypropylene resin particles comprise: the polypropylene resin (X); no or only one foam nucleating agent; and a hydrophilic compound, wherein the polypropylene resin (X) comprises: 85 to 99 weight % of a polypropylene resin (I); 1 to 15 weight % of a high density polyethylene resin (II), a total amount of the polypropylene resin (I) and the high density polyethylene resin (II) being 100 weight %, wherein the polypropylene resin (I) has a melt flow rate of 3 to 20 g/10 min.", "and a melting point of 145 to 165° C., wherein the high density polyethylene resin (II) has a density of 0.93 to 0.97 g/cm3 and a melt flow rate of 0.1 to 15 g/10 min., and wherein the expanded polypropylene resin particles have an expansion ratio ranging from 10 to 40 times, an average cell diameter of 100 to 250 μm, and an open cell ratio ranging from 0 to 10%.", "9.The method according to claim 8, wherein the inorganic gas-based foaming agent is carbon dioxide.", "10.The method according to claim 8, wherein the melting point of the polypropylene resin (I) is 148 to 160° C. 11.The method according to claim 8, wherein a melting point of the high density polyethylene resin (II) is 125 to 135° C. 12.The method according to claim 8, wherein a melting point of the high density polyethylene resin (II) is 125 to 130° C. 13.The method according to claim 8, wherein the high density polyethylene resin (II) has a flexural modulus of 800 to 1600 MPa.", "14.The method according to claim 8, wherein an amount of the foam nucleating agent is 0.005 to 2 parts by weight with respect to 100 parts by weight of the polypropylene resin (X).", "15.The method according to claim 8, wherein the hydrophilic compound is at least one selected from the group consisting of melamine, glycerin, diglycerin, and polyethylene glycol.", "16.A method for producing a polypropylene resin in-mold expanded molded product, comprising molding the expanded polypropylene resin particle according to claim 1, wherein a molding cycle is 5 to 20% shorter than a molding cycle of a method for producing a polypropylene resin in-mold expanded molded product using an expanded polypropylene resin particle that contains, as a base resin, a polypropylene resin composed of the polypropylene resin (I) alone.", "17.A polypropylene resin in-mold expanded molded product obtained by molding the expanded polypropylene resin particle according to claim 1, wherein the polypropylene resin in-mold expanded molded product has a density of 10 to 60 g/L and an open cell ratio ranging from 0 to 10%." ], [ "<SOH> BACKGROUND <EOH>Polypropylene resin in-mold expanded molded products, which are obtained from expanded polypropylene resin particles composed of a polypropylene resin, have been used in various applications such as not only car interior materials and car bumper core materials but also heat insulators, shock-absorbing packing materials, and returnable containers.", "Especially in car applications in recent years, the cars are becoming more lightweight under environmental concerns, and therefore the following method has been used: a method of achieving the weight reduction of the cars while maintaining the strength equivalent to those of existing cars, by using a high-strength polypropylene resin in-mold expanded molded product in a car interior material, a car bumper core, and/or the like.", "Generally, in order to obtain a high-strength polypropylene resin in-mold expanded molded product, it is preferable to select a polypropylene resin that has high flexural modulus.", "Polypropylene resins having high flexural modulus tend to have a high degree of resin crystallinity and high melting point, and their crystal heat capacity tends to be large.", "However, expanded particles obtained from a high-strength polypropylene resin tend to have fine cell diameter, which results in a tendency to impair the surface properties of the in-mold expanded molded product.", "Meanwhile, an in-mold expanded molded product with higher expansion ratio has poorer surface properties.", "In the case of high expansion ratio, the in-mold expanded molded product has a poor surface appearance as described below: the in-mold expanded molded product is likely to have an uneven (i.e., the surface is dented in areas between expanded particles) and wrinkled surface; mold transferability is poor at an edge (ridge) where faces of the in-mold expanded molded product meet and thus the edge is not smooth and the shapes of expanded particles are noticeable; or the like.", "Furthermore, in some cases, the in-mold expanded molded product may shrink, which may lead to reduced dimensional accuracy.", "There is a known method of improving surface properties to avoid the above-described issues.", "The method includes adding, to a polypropylene resin, a polyethylene wax having a molecular weight of 1000 to 4000 and a melting point of 100° C. or above and 130° C. or below (for example, Patent Literature 1).", "However, this method has an issue in that, due to the low strength of the polyethylene wax, the mechanical strength of the in-mold expanded molded product decreases and the molding cycle in in-mold foaming molding becomes long and productivity decreases.", "There is another known method of improving surface properties by adding, to a polypropylene resin, a polyolefin oligomer having a molecular weight of 1500 to 25000 (for example, Patent Literature 2).", "However, this method has an issue in that, due to the low strength of the polyolefin oligomer, the strength of the in-mold expanded molded product decreases and the molding cycle in in-mold foaming molding becomes long and productivity decreases.", "The following method is also known: a method of attempting to improve surface properties by adding a linear low-density polyethylene to a polypropylene resin (for example, Patent Literature 3).", "However, this method has an issue in that the mechanical strength of the in-mold expanded molded product decreases due to the low strength of the linear low-density polyethylene.", "In one or more embodiments of the present invention, the following method is known: a method of attempting to obtain expanded particles with cells uniform in size by adding, to 50 to 99 weight % of a polypropylene resin, 1 to 50 weight % of a polyethylene resin having a density of 0.92 to 0.97 g/cm 3 , a melt flow rate of 1 to 20 g/10 min., and specific melting characteristics (for example Patent Literature 4).", "Examples of a volatile foaming agent disclosed in Patent Literature 4 are all organic foaming agents that have a high global warming potential, and Patent Literature 4 is totally silent about the use of an inorganic gas.", "Organic foaming agents have an issue in that they impose significant environmental loads.", "In addition, there is a drawback that the organic foaming agents require explosion-proof facilities and thus the facility becomes costly.", "Furthermore, Patent Literature 4 discloses, in Examples 1 and 2 and Comparative Examples 3 and 4, the cell diameters obtained when the amount of polyethylene added to the polypropylene resin is increased.", "Patent Literature 4 states that, when polyethylene is added in an amount as small as 0.1 weight %, the resulting cell diameter is as huge as 690 μm and this deteriorates fusibility etc.", "of the in-mold expanded molded product.", "When polyethylene is added in an amount as large as 20 to 30 weight %, the resulting cell diameter is relatively large: 360 to 320 μm.", "When polyethylene is added in an amount of 52 weight % which is about half the resin weight, the resulting cell diameter is about 250 μm.", "The in-mold expanded molded product having a cell diameter of 250 μm has an issue in that it has a reduced strength.", "According to one or more embodiments of the present invention, the following method is known: a method of attempting to obtain expanded particles with large cell diameter by adding two or more inorganic antiblocking agents in an amount of 0.03 parts by weight or more and 2 parts by weight or less in total to 100 parts by weight of a polyolefin resin.", "This is for the purpose of making use of the polyolefin resin, which is generally for use in films, for in-mold foaming molding (for example, Patent Literature 5)." ], [ "<SOH> SUMMARY <EOH>In order to reduce surface property deterioration of a molded product that would occur when it is obtained from a high-melting, high-elastic-modulus polypropylene resin through in-mold foaming molding, one or more embodiments of the present invention provide expanded polypropylene resin particles that can achieve good surface appearance and short molding cycle in in-mold foaming molding while maintaining good compressive strength characteristics which are characteristic to the high-modulus polypropylene resin.", "The inventors of the present disclosure found that expanded polypropylene resin particles obtained from a polypropylene resin having a specific configuration would give a high-strength in-mold expanded molded product that is good in surface appearance and that achieves short molding cycle in in-mold foaming molding.", "Specifically, one or more embodiments of the present invention are directed to an expanded polypropylene resin particle containing a polypropylene resin (X) as a base resin, the polypropylene resin (X) containing a polypropylene resin (I) in an amount of 85 to 99 weight % and a high density polyethylene resin (II) in an amount of 1 to 15 weight % so that the total amount of the polypropylene resin (I) and the high density polyethylene resin (II) is 100 weight %, and the polypropylene resin (I) having a melt flow rate of 3 g/10 min.", "or more and 20 g/10 min.", "or less and a melting point of 145° C. or above and 165° C. or below, and the high density polyethylene resin (II) having a density of 0.93 to 0.97 g/cm 3 and a melt flow rate of 0.1 g/10 min.", "or more and 15 g/10 min.", "or less, wherein no or one foam nucleating agent is contained in the polypropylene resin (X), wherein a hydrophilic compound is contained in the polypropylene resin (X), and wherein the expanded polypropylene resin particle has an expansion ratio of 10 times or greater and 40 times or less, an average cell diameter of 100 μm or greater and 250 μm or less, and an open cell ratio of 0% or greater and 10% or less.", "One or more embodiments of the present invention are directed to a method for producing expanded polypropylene resin particles containing a polypropylene resin (X) as a base resin, the polypropylene resin (X) containing a polypropylene resin (I) in an amount of 85 to 99 weight % and a high density polyethylene resin (II) in an amount of 1 to 15 weight % so that the total amount of the polypropylene resin (I) and the high density polyethylene resin (II) is 100 weight %, and the polypropylene resin (I) having a melt flow rate of 3 g/10 min.", "or more and 20 g/10 min.", "or less and a melting point of 145° C. or above and 165° C. or below, and the high density polyethylene resin (II) having a density of 0.93 to 0.97 g/cm 3 and a melt flow rate of 0.1 g/10 min.", "or more and 15 g/10 min.", "or less, wherein no or one foam nucleating agent is contained in the polypropylene resin (X), wherein a hydrophilic compound is contained in the polypropylene resin (X), and wherein the expanded polypropylene resin particles have an expansion ratio of 10 times or greater and 40 times or less, an average cell diameter of 100 μm or greater and 250 μm or less, and an open cell ratio of 0% or greater and 10% or less, the method including: obtaining a dispersion slurry by placing water, an inorganic gas-based foaming agent, and polypropylene resin particles composed of the polypropylene resin (X) in a pressure-resistant container and dispersing the polypropylene resin particles with stirring, and increasing temperature and pressure; and thereafter releasing the dispersion slurry from the pressure-resistant container to a region having a pressure lower than the internal pressure of the pressure-resistant container to expand the polypropylene resin particles.", "One or more embodiments of the present invention are directed to a method for producing a polypropylene resin in-mold expanded molded product from an expanded polypropylene resin particle in accordance with one or more embodiments of the present invention, wherein a molding cycle is 5 to 20% shorter than a molding cycle of a method for producing a polypropylene resin in-mold expanded molded product from expanded polypropylene resin particles that contain, as a base resin, a polypropylene resin composed of the polypropylene resin (I) alone.", "One or more embodiments of the present invention are directed to a polypropylene resin in-mold expanded molded product obtained from an expanded polypropylene resin particle in accordance with one or more embodiments of the present invention, the polypropylene resin in-mold expanded molded product having a density of 10 g/L or greater and 60 g/L or less and an open cell ratio of 0 to 10%.", "When expanded polypropylene resin particles of one or more embodiments of the present invention are molded through in-mold foaming, a polypropylene in-mold expanded molded product having an improved surface appearance and a high strength is obtained with a short molding cycle even if the amount of the polyethylene resin added is small.", "Since a high-strength in-mold expanded molded product is obtained, the weight reduction of the molded product can be achieved while keeping the compressive strength necessary for structural components satisfied." ], [ "TECHNICAL FIELD One or more embodiments of the present invention relate to expanded polypropylene resin particles, a method for producing expanded polypropylene resin particles, a method for producing a polypropylene resin in-mold expanded molded product, and a polypropylene resin in-mold expanded molded product.", "BACKGROUND Polypropylene resin in-mold expanded molded products, which are obtained from expanded polypropylene resin particles composed of a polypropylene resin, have been used in various applications such as not only car interior materials and car bumper core materials but also heat insulators, shock-absorbing packing materials, and returnable containers.", "Especially in car applications in recent years, the cars are becoming more lightweight under environmental concerns, and therefore the following method has been used: a method of achieving the weight reduction of the cars while maintaining the strength equivalent to those of existing cars, by using a high-strength polypropylene resin in-mold expanded molded product in a car interior material, a car bumper core, and/or the like.", "Generally, in order to obtain a high-strength polypropylene resin in-mold expanded molded product, it is preferable to select a polypropylene resin that has high flexural modulus.", "Polypropylene resins having high flexural modulus tend to have a high degree of resin crystallinity and high melting point, and their crystal heat capacity tends to be large.", "However, expanded particles obtained from a high-strength polypropylene resin tend to have fine cell diameter, which results in a tendency to impair the surface properties of the in-mold expanded molded product.", "Meanwhile, an in-mold expanded molded product with higher expansion ratio has poorer surface properties.", "In the case of high expansion ratio, the in-mold expanded molded product has a poor surface appearance as described below: the in-mold expanded molded product is likely to have an uneven (i.e., the surface is dented in areas between expanded particles) and wrinkled surface; mold transferability is poor at an edge (ridge) where faces of the in-mold expanded molded product meet and thus the edge is not smooth and the shapes of expanded particles are noticeable; or the like.", "Furthermore, in some cases, the in-mold expanded molded product may shrink, which may lead to reduced dimensional accuracy.", "There is a known method of improving surface properties to avoid the above-described issues.", "The method includes adding, to a polypropylene resin, a polyethylene wax having a molecular weight of 1000 to 4000 and a melting point of 100° C. or above and 130° C. or below (for example, Patent Literature 1).", "However, this method has an issue in that, due to the low strength of the polyethylene wax, the mechanical strength of the in-mold expanded molded product decreases and the molding cycle in in-mold foaming molding becomes long and productivity decreases.", "There is another known method of improving surface properties by adding, to a polypropylene resin, a polyolefin oligomer having a molecular weight of 1500 to 25000 (for example, Patent Literature 2).", "However, this method has an issue in that, due to the low strength of the polyolefin oligomer, the strength of the in-mold expanded molded product decreases and the molding cycle in in-mold foaming molding becomes long and productivity decreases.", "The following method is also known: a method of attempting to improve surface properties by adding a linear low-density polyethylene to a polypropylene resin (for example, Patent Literature 3).", "However, this method has an issue in that the mechanical strength of the in-mold expanded molded product decreases due to the low strength of the linear low-density polyethylene.", "In one or more embodiments of the present invention, the following method is known: a method of attempting to obtain expanded particles with cells uniform in size by adding, to 50 to 99 weight % of a polypropylene resin, 1 to 50 weight % of a polyethylene resin having a density of 0.92 to 0.97 g/cm3, a melt flow rate of 1 to 20 g/10 min., and specific melting characteristics (for example Patent Literature 4).", "Examples of a volatile foaming agent disclosed in Patent Literature 4 are all organic foaming agents that have a high global warming potential, and Patent Literature 4 is totally silent about the use of an inorganic gas.", "Organic foaming agents have an issue in that they impose significant environmental loads.", "In addition, there is a drawback that the organic foaming agents require explosion-proof facilities and thus the facility becomes costly.", "Furthermore, Patent Literature 4 discloses, in Examples 1 and 2 and Comparative Examples 3 and 4, the cell diameters obtained when the amount of polyethylene added to the polypropylene resin is increased.", "Patent Literature 4 states that, when polyethylene is added in an amount as small as 0.1 weight %, the resulting cell diameter is as huge as 690 μm and this deteriorates fusibility etc.", "of the in-mold expanded molded product.", "When polyethylene is added in an amount as large as 20 to 30 weight %, the resulting cell diameter is relatively large: 360 to 320 μm.", "When polyethylene is added in an amount of 52 weight % which is about half the resin weight, the resulting cell diameter is about 250 μm.", "The in-mold expanded molded product having a cell diameter of 250 μm has an issue in that it has a reduced strength.", "According to one or more embodiments of the present invention, the following method is known: a method of attempting to obtain expanded particles with large cell diameter by adding two or more inorganic antiblocking agents in an amount of 0.03 parts by weight or more and 2 parts by weight or less in total to 100 parts by weight of a polyolefin resin.", "This is for the purpose of making use of the polyolefin resin, which is generally for use in films, for in-mold foaming molding (for example, Patent Literature 5).", "CITATION LIST Patent Literature [Patent Literature 1] Japanese Patent Application Publication Tokukai No.", "2009-114359 (Publication date: May 28, 2009) [Patent Literature 2] Japanese Patent Application Publication Tokukai No.", "2009-084547 (Publication date: Apr.", "23, 2009) [Patent Literature 3] Japanese Patent Application Publication Tokukai No.", "2008-255286 (Publication date: Oct. 23, 2008) [Patent Literature 4] Japanese Patent Application Publication Tokukai No.", "2010-275499 (Publication date: Dec. 9, 2010) [Patent Literature 5] PCT International Publication No.", "WO2015/098619 (Publication Date: Jul.", "2, 2015) SUMMARY In order to reduce surface property deterioration of a molded product that would occur when it is obtained from a high-melting, high-elastic-modulus polypropylene resin through in-mold foaming molding, one or more embodiments of the present invention provide expanded polypropylene resin particles that can achieve good surface appearance and short molding cycle in in-mold foaming molding while maintaining good compressive strength characteristics which are characteristic to the high-modulus polypropylene resin.", "The inventors of the present disclosure found that expanded polypropylene resin particles obtained from a polypropylene resin having a specific configuration would give a high-strength in-mold expanded molded product that is good in surface appearance and that achieves short molding cycle in in-mold foaming molding.", "Specifically, one or more embodiments of the present invention are directed to an expanded polypropylene resin particle containing a polypropylene resin (X) as a base resin, the polypropylene resin (X) containing a polypropylene resin (I) in an amount of 85 to 99 weight % and a high density polyethylene resin (II) in an amount of 1 to 15 weight % so that the total amount of the polypropylene resin (I) and the high density polyethylene resin (II) is 100 weight %, and the polypropylene resin (I) having a melt flow rate of 3 g/10 min.", "or more and 20 g/10 min.", "or less and a melting point of 145° C. or above and 165° C. or below, and the high density polyethylene resin (II) having a density of 0.93 to 0.97 g/cm3 and a melt flow rate of 0.1 g/10 min.", "or more and 15 g/10 min.", "or less, wherein no or one foam nucleating agent is contained in the polypropylene resin (X), wherein a hydrophilic compound is contained in the polypropylene resin (X), and wherein the expanded polypropylene resin particle has an expansion ratio of 10 times or greater and 40 times or less, an average cell diameter of 100 μm or greater and 250 μm or less, and an open cell ratio of 0% or greater and 10% or less.", "One or more embodiments of the present invention are directed to a method for producing expanded polypropylene resin particles containing a polypropylene resin (X) as a base resin, the polypropylene resin (X) containing a polypropylene resin (I) in an amount of 85 to 99 weight % and a high density polyethylene resin (II) in an amount of 1 to 15 weight % so that the total amount of the polypropylene resin (I) and the high density polyethylene resin (II) is 100 weight %, and the polypropylene resin (I) having a melt flow rate of 3 g/10 min.", "or more and 20 g/10 min.", "or less and a melting point of 145° C. or above and 165° C. or below, and the high density polyethylene resin (II) having a density of 0.93 to 0.97 g/cm3 and a melt flow rate of 0.1 g/10 min.", "or more and 15 g/10 min.", "or less, wherein no or one foam nucleating agent is contained in the polypropylene resin (X), wherein a hydrophilic compound is contained in the polypropylene resin (X), and wherein the expanded polypropylene resin particles have an expansion ratio of 10 times or greater and 40 times or less, an average cell diameter of 100 μm or greater and 250 μm or less, and an open cell ratio of 0% or greater and 10% or less, the method including: obtaining a dispersion slurry by placing water, an inorganic gas-based foaming agent, and polypropylene resin particles composed of the polypropylene resin (X) in a pressure-resistant container and dispersing the polypropylene resin particles with stirring, and increasing temperature and pressure; and thereafter releasing the dispersion slurry from the pressure-resistant container to a region having a pressure lower than the internal pressure of the pressure-resistant container to expand the polypropylene resin particles.", "One or more embodiments of the present invention are directed to a method for producing a polypropylene resin in-mold expanded molded product from an expanded polypropylene resin particle in accordance with one or more embodiments of the present invention, wherein a molding cycle is 5 to 20% shorter than a molding cycle of a method for producing a polypropylene resin in-mold expanded molded product from expanded polypropylene resin particles that contain, as a base resin, a polypropylene resin composed of the polypropylene resin (I) alone.", "One or more embodiments of the present invention are directed to a polypropylene resin in-mold expanded molded product obtained from an expanded polypropylene resin particle in accordance with one or more embodiments of the present invention, the polypropylene resin in-mold expanded molded product having a density of 10 g/L or greater and 60 g/L or less and an open cell ratio of 0 to 10%.", "When expanded polypropylene resin particles of one or more embodiments of the present invention are molded through in-mold foaming, a polypropylene in-mold expanded molded product having an improved surface appearance and a high strength is obtained with a short molding cycle even if the amount of the polyethylene resin added is small.", "Since a high-strength in-mold expanded molded product is obtained, the weight reduction of the molded product can be achieved while keeping the compressive strength necessary for structural components satisfied.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 shows one example of a DSC curve (temperature vs heat absorption quantity) obtained by differential scanning calorimetry (DSC) in which the temperature of expanded polypropylene resin particles in accordance with one or more embodiments of the present invention is raised from 40° C. to 220° C. at a heating rate of 10° C./min.", "FIG.", "1 shows a case in which the base resin consists only of one polypropylene resin and contains no polyethylene resins.", "The DSC curve shows two melting peaks and has two melting heat quantity regions: the low-temperature-side melting heat quantity region Ql; and the high-temperature-side melting heat quantity region Qh.", "FIG.", "2 shows one example of a DSC curve (temperature vs heat absorption quantity) obtained by differential scanning calorimetry (DSC) in which the temperature of expanded polypropylene resin particles in accordance with one or more embodiments of the present invention is raised from 40° C. to 220° C. at a heating rate of 10° C./min.", "FIG.", "2 shows a case in which the base resin is a mixture of a polypropylene resin and a polyethylene resin (hereinafter may be referred to as PE) according to one or more embodiments of the present invention.", "The DSC curve may have the third peak resulting from PE at around 125° C. to 130° C. as compared with FIG.", "1, depending on the amount of PE.", "In a case where three melting peaks appear, there are two points that can serve as the smallest heat absorption quantity between two adjacent melting heat quantity regions.", "In such a case, the point at the high-temperature side is defined as point C. Based on point C, the low-temperature-side melting heat quantity region Ql and the high-temperature-side melting heat quantity region Qh are calculated.", "FIG.", "3 shows one example of a DSC curve obtained when a base resin of expanded polypropylene resin particles in accordance with one or more embodiments of the present invention is heated from 40° C. to 220° C. at a heating rate of 10° C./min.", "and thereafter cooled from 220° C. to 40° C. at a rate of 10° C./min.", "and again heated from 40° C. to 220° C. at a rate of 10° C./min.", "The DSC curve is that obtained in the second temperature rise.", "FIG.", "3 shows a case in which the base resin consists only of one polypropylene resin and contains no polyethylene resins according to one or more embodiments of the present invention.", "The “tm” indicates melting point.", "The “tf” indicates melt end temperature, which is the temperature at which the high-temperature-side tail of the melting peak in the second temperature rise meets the base line at the high-temperature side.", "FIG.", "4 shows one example of a DSC curve obtained when a base resin of expanded polypropylene resin particles in accordance with one or more embodiments of the present invention is heated from 40° C. to 220° C. at a heating rate of 10° C./min.", "and thereafter cooled from 220° C. to 40° C. at a rate of 10° C./min.", "and again heated from 40° C. to 220° C. at a rate of 10° C./min.", "The DSC curve is that obtained in the second temperature rise.", "FIG.", "4 shows a case in which the base resin is a mixture of a polypropylene resin and a polyethylene resin according to one or more embodiments of the present invention.", "The “tm” indicates melting point.", "The “tf” indicates melt end temperature, which is the temperature at which the high-temperature-side tail of the melting peak in the second temperature rise meets the base line at the high-temperature side.", "The DSC curve may have the third peak resulting from PE at around 125° C. to 130° C. as compared with FIG.", "3, depending on the amount of PE.", "DETAILED DESCRIPTION OF THE EMBODIMENTS The following description will discuss one or more embodiments of the present invention on the basis of specific examples.", "However, the present invention is not limited to the following embodiments.", "The present invention is not limited to any of configurations described below, but can be altered in many ways within the scope of the claims.", "An embodiment and/or an example derived from a combination of technical means disclosed in different embodiments and/or examples are/is also encompassed in the technical scope of the present invention.", "In addition, all of the patent literatures listed herein are incorporated by reference herein.", "Furthermore, any numerical range expressed as “A to B” in the present specification means “A or greater (A inclusive) and B or less (B inclusive)” unless otherwise stated.", "1.Expanded Polypropylene Resin Particles Expanded polypropylene resin particles in accordance with one or more embodiments of the present invention are expanded polypropylene resin particles containing a polypropylene resin (X) as a base resin.", "The polypropylene resin (X) contains a polypropylene resin (I) in an amount of 85 to 99 weight % and a high density polyethylene resin (II) in an amount of 1 to 15 weight % so that the total amount of the polypropylene resin (I) and the high density polyethylene resin (II) is 100 weight %.", "The polypropylene resin (I) has a melt flow rate of 3 g/10 min.", "or more and 20 g/10 min.", "or less and a melting point of 145° C. or above and 165° C. or below.", "The high density polyethylene resin (II) has a density of 0.93 to 0.97 g/cm3 and a melt flow rate of 0.1 g/10 min.", "or more and 15 g/10 min.", "or less.", "No or one foam nucleating agent is contained in the polypropylene resin (X).", "A hydrophilic compound is contained in the polypropylene resin (X).", "The expanded polypropylene resin particle has an expansion ratio of 10 times or greater and 40 times or less, an average cell diameter of 100 μm or greater and 250 μm or less, and an open cell ratio of 0% or greater and 10% or less.", "The polypropylene resin (I) in accordance with one or more embodiments of the present invention has a melting point as high as 145° C. or above and 165° C. or below, and thus is a high-strength polypropylene resin.", "Use of a high-strength polypropylene resin provides a high-strength polypropylene resin in-mold expanded molded product, but the expanded particles resulting from the high-strength polypropylene resin usually tend to have fine cell diameter.", "The reason for this seems to be that crystals in a resin serve as expansion nuclei and that the use of the high-melting polypropylene resin having a high degree of crystallinity increases the number of the expansion nuclei.", "Thus, when trying to obtain expanded polypropylene resin particles from a high-strength polypropylene resin, the cell diameter of the expanded particles becomes fine, resulting in a tendency to deteriorate the surface properties of an in-mold expanded molded product obtained through in-mold foaming molding of the resulting expanded particles.", "In this regard, the expanded polypropylene resin particles in accordance with one or more embodiments of the present invention include the above features, and therefore the cell diameter of the expanded polypropylene resin particles does not become fine and achieves uniformity.", "The result is that an in-mold expanded molded product obtained through in-mold foaming molding of the resulting expanded particles has high strength and good surface properties.", "It is noted that, in this specification, “expanded polypropylene resin particles” may be referred to as “expanded particles” for short.", "It is noted that, in this specification, a “polypropylene resin in-mold expanded molded product” obtained by molding expanded polypropylene resin particles may be referred to as an “in-mold expanded molded product” for short.", "It is noted that, in this specification, a “method for producing a polypropylene resin in-mold expanded molded product” from expanded polypropylene resin particles may be referred to as “a production method of an in-mold expanded molded product” for short.", "1-1.Polypropylene Resin (I) The polypropylene resin (I) for use in one or more embodiments of the present invention is preferably a polypropylene random copolymer that contains propylene and a comonomer(s) other than propylene, from the viewpoint of production stability of expanded particles and the strength of an in-mold expanded molded product obtained through in-mold foaming molding of the resulting expanded particles.", "Examples of the comonomer include C2 or C4 to C12 α-olefins such as 1-butene, ethylene, isobutene, 1-pentene, 3-methyl-1-butene, 1-hexene, 4-methyl-1-pentene, 3,4-dimethyl-1-butene, 1-heptene, 3-methyl-1-hexene, 1-octene, and 1-decene.", "One of these comonomers may be used individually or two or more of these comonomers may be used in combination.", "Of these comonomers, 1-butene and/or ethylene is/are preferred because they achieve good foamability in obtaining expanded polypropylene resin particles and provide good surface appearance of a polypropylene resin in-mold expanded molded product obtained through in-mold foaming molding of the resulting expanded particles.", "The comonomer is more preferably 1-butene, because this makes it possible to obtain a polypropylene resin composition having a flexural modulus of 1200 MPa or greater and 1700 MPa or less (this will be described later).", "The total amount of comonomers contained in the polypropylene resin (I) for use in one or more embodiments of the present invention is not particularly limited, and is preferably 0.5 weight % or more and 10 weight % or less, more preferably 1.5 weight % or more and 8 weight % or less, even more preferably 2.5 weight % or more and 6 weight % or less, with respect to 100 weight % of the polypropylene resin (I).", "A polypropylene resin in which the total amount of comonomers is less than 0.5 weight % strongly tends to have a high melting point and, when the resulting expanded particles are to be molded through in-mold foaming, a molding pressure (steam heating pressure) exceeds 0.40 MPa (gage pressure) and the particles may be difficult to mold.", "If the total amount of the comonomers is more than 10 weight %, the steam heating pressure for in-mold foaming molding of the resulting expanded particles decreases.", "However, the melting point of the polypropylene resin itself lowers and the expandability in the in-mold foaming molding increases, and thus the molding cycle tends to become long and the resulting in-mold expanded molded product tends not to satisfy practical rigidity such as compressive strength.", "In the case where the practical rigidity of the in-mold expanded molded product is not satisfactory, the expansion ratio of the molded product in in-mold foaming molding has to be reduced and, in such a case, a lightweight molded product cannot be easily obtained.", "The polypropylene resin (I) for use in one or more embodiments of the present invention has a melt flow rate (hereinafter referred to as “MFR”) of preferably 3 g/10 min.", "or more and 20 g/10 min.", "or less, more preferably 5 g/10 min.", "or more and 15 g/10 min.", "or less, most preferably 6 g/10 min.", "or more and 12 g/10 min.", "or less.", "In a case where the MFR of the polypropylene resin (I) is less than 3 g/10 min., an in-mold expanded molded product obtained through in-mold foaming molding of the resulting expanded particles tends to have a deteriorated surface appearance.", "In a case where the MFR is more than 20 g/10 min., the expandability in in-mold foaming molding increases too much and thus the molding cycle tends to become long.", "Note that the MFR of the polypropylene resin (I) in accordance with one or more embodiments of the present invention is measured with the use of an MFR measuring instrument described in JIS-K7210 and under conditions involving an orifice having a diameter of 2.0959±0.005 mm and a length of 8.000±0.025 mm, a load of 2160 g, and a temperature of 230° C.±0.2° C. The polypropylene resin (I) for use in one or more embodiments of the present invention has a melting point of preferably 145° C. or above and 165° C. or below, more preferably 148° C. or above and 160° C. or below, even more preferably 148° C. or above and 158° C. or below, particularly preferably 148° C. or above and 155° C. or below.", "It should be noted, here, that the melting point of the polypropylene resin (I) is measured in the following manner: 1 mg or more and 10 mg or less of the polypropylene resin (I) is heated from 40° C. to 220° C. at a rate of 10° C./min.", "and thereafter cooled from 220° C. to 40° C. at a rate of 10° C./min.", "and again heated from 40° C. to 220° C. at a rate of 10° C./min.", "with the use of a differential scanning calorimeter DSC to obtain a DSC curve; and the melting peak temperature on the DSC curve in the second temperature rise is used as the melting point of the polypropylene resin (I).", "In a case where the melting point of the polypropylene resin (I) is below 145° C., an in-mold expanded molded product obtained through in-mold foaming molding of the resulting expanded particles tends to have insufficient compressive strength.", "In a case where the melting point is above 165° C., the mold heating pressure in in-mold foaming molding tends to become too high and the expanded particles tend to be unmoldable with a usual in-mold foaming molding apparatus resistant to pressure of up to 0.4 MPa (gage pressure).", "Such a polypropylene resin (I) may be one polypropylene resin alone or a mixture of two or more different polypropylene resins.", "The method of obtaining the mixture is not limited to a particular kind, and may be, for example, a method by which the polypropylene resins are mixed with the use of a blender or the like or a method by which the polypropylene resins are blended through polymerization performed in multiple steps.", "A polymerization catalyst for polymerization of a polypropylene resin is not limited to a particular kind, and may be any of various catalysts such as a Ziegler-Natta catalyst, a metallocene catalyst, and/or the like.", "1-2.High Density Polyethylene Resin (II) The polypropylene resin (X), which is a base resin of the expanded polypropylene resin particles in accordance with one or more embodiments of the present invention, is obtained by mixing a high density polyethylene resin (II) with the polypropylene resin (I).", "The polypropylene resin (X) serving as the base resin, which contains the high density polyethylene resin (II) in addition to the polypropylene resin (I), brings about an effect such that the cell diameter of the resulting expanded particles does not become too fine and that, despite a relatively small cell diameter, an in-mold expanded molded product having a good surface appearance can be obtained without impairing compressive strength characteristics.", "The high density polyethylene resin (II) for use in one or more embodiments of the present invention has a density of preferably 0.93 g/cm3 or greater, more preferably 0.95 g/cm3 or greater and 0.97 g/cm3 or less.", "If the density of the high density polyethylene resin (II) is less than 0.93 g/cm3, the resulting expanded particles tend to have nonuniform cell diameter.", "If the density is greater than 0.97 g/cm3, the foamability tends to decrease in obtaining expanded particles.", "The MFR of the high density polyethylene resin (II) for use in one or more embodiments of the present invention is preferably 0.1 g/10 min.", "or more and 20 g/10 min.", "or less, more preferably 0.1 g/10 min.", "or more and 15 g/10 min.", "or less, in view of the surface appearance of an in-mold expanded molded product obtained through in-mold foaming molding of the resulting expanded particles and in view of the molding cycle in the in-mold foaming molding.", "Note that the MFR of the high density polyethylene resin (II) is measured in accordance with JIS K7210 with a load of 2160 g and a temperature of 190° C.±0.2° C. The melting point of the high density polyethylene resin (II) for use in one or more embodiments of the present invention is not particularly limited, and is preferably 125° C. or above and 135° C. or below, more preferably 125° C. or above and 130° C. or below, even more preferably 128° C. or above and 130° C. or below.", "It should be noted, here, that the melding point of the high density polyethylene resin (II) is measured in the following manner: 1 mg or more and 10 mg or less of the high density polyethylene resin (II) is heated from 40° C. to 220° C. at a rate of 10° C./min.", "and thereafter cooled from 220° C. to 40° C. at a rate of 10° C./min.", "and again heated from 40° C. to 220° C. at a rate of 10° C./min.", "with the use of a differential scanning calorimeter DSC to obtain a DSC curve; and the melting peak temperature on the DSC curve in the second temperature rise is used as the melting point of the high density polyethylene resin (II).", "If the melting point of the high density polyethylene resin (II) is below 125° C., an in-mold expanded molded product obtained through in-mold foaming molding of the resulting expanded particles tends to have decreased practical rigidity such as decreased compressive strength.", "If the melting point is above 135° C., there is a tendency that the mixing of the polypropylene resin (I) and the high density polyethylene resin (II) is not so effective for the in-mold expanded molded product.", "The high density polyethylene resin (II) in accordance with one or more embodiments of the present invention preferably has a flexural modulus of 800 MPa or greater and 1600 MPa or less.", "Note here that the flexural modulus of the high density polyethylene resin (II) was measured by: drying the high density polyethylene resin (II) at 80° C. for 6 hours; then preparing a bar having a thickness of 6.4 mm (a width of 12.7 mm and a length of 127 mm) by use of a 35 t injection molding machine at a cylinder temperature of 200° C. and a mold temperature of 30° C.; and performing a flexural test with respect to the bar in accordance with ASTM D790 within a week of the preparation of the bar.", "The high density polyethylene resin (II) for use in one or more embodiments of the present invention may contain a comonomer, other than ethylene, which is copolymerizable with ethylene.", "Examples of the comonomer copolymerizable with ethylene include C3 to C18 α-olefins such as propylene, 1-butene, 1-pentene, 1-hexene, 3,3-dimethyl-1-butene, 4-methyl-1-pentene, 4,4-dimethyl-1-pentene, and 1-octene.", "Each of these comonomers may be used individually or two or more of these comonomers may be used in combination.", "1-3.Polypropylene Resin (X) It is preferable that the polypropylene resin (X) in accordance with one or more embodiments of the present invention contain the polypropylene resin (I) in an amount of 85 to 99 weight % and the high density polyethylene resin (II) in an amount of 1 to 15 weight % so that the total amount of the polypropylene resin (I) and the high density polyethylene resin (II) is 100 weight %.", "It is more preferable that the polypropylene resin (X) contain the polypropylene resin (I) in an amount of 86 to 98 weight % and the high density polyethylene resin (II) in an amount of 2 to 14 weight %.", "If the percentage of the high density polyethylene resin (II) contained in the polypropylene resin (X) is less than 1 weight % (the total amount of the polypropylene resin (I) and the high density polyethylene resin (II) is 100 weight %), there is a tendency that the molding cycle in in-mold foaming molding of the resulting expanded particles is difficult to shorten.", "If the percentage of the high density polyethylene resin (II) contained in the polypropylene resin (X) is more than 15 weight %, there is a tendency that the resulting expanded polypropylene resin particles have a high open cell ratio and that an in-mold expanded molded product obtained through in-mold foaming molding of the resulting expanded particles has decreased strength.", "The polypropylene resin (X) for use in one or more embodiments of the present invention has a flexural modulus of preferably 1200 MPa or greater and 1700 MPa or less, more preferably 1200 MPa or greater and 1550 MPa or less, for an in-mold expanded molded product obtained through in-mold foaming molding of the resulting expanded particles to have both high strength and good surface appearance.", "Generally, a polypropylene resin in-mold expanded molded product, which is obtained through in-mold foaming molding of the expanded polypropylene resin particles made from a polypropylene resin having high flexural modulus, tends to have decreased fusibility because the expanded polypropylene resin particles have fine cell diameter and thus the expanded particles have lower expandability in the in-mold foaming molding.", "This leads to a tendency that the molding pressure for obtaining a good in-mold expanded molded product becomes high in the in-mold foaming molding.", "In this regard, according to one or more embodiments of the present invention, the cell diameter of the resulting expanded polypropylene resin particles is prevented from becoming fine or becoming too fine, and therefore the expandability of the expanded particles does not tend to decrease even with a relatively low molding pressure.", "This gives an in-mold expanded molded product having a good-looking surface.", "In addition, the in-mold expanded molded product tends to have high compressive strength.", "Therefore, the in-mold expanded molded product is suitable for use in applications that require high rigidity such as bumpers and in applications that require durability such as returnable containers.", "One or more embodiments of the present invention also bring about an effect such that a more lightweight in-mold expanded molded product can be obtained.", "For the polypropylene resin (X) to have a flexural modulus of 1200 MPa or greater and 1700 MPa or less, the polypropylene resin in the polypropylene resin (X) is preferably composed mainly of the earlier-described polypropylene resin (I).", "It is especially preferable that a polypropylene resin containing a small amount of comonomer be used and that 1-butene be contained as a comonomer.", "Note that the flexural modulus of the polypropylene resin (X) was measured by: drying the polypropylene resin (X) at 80° C. for 6 hours; then preparing a bar having a thickness of 6.4 mm (a width of 12.7 mm and a length of 127 mm) by use of a 35 t injection molding machine at a cylinder temperature of 200° C. and a mold temperature of 30° C.; and performing a flexural test with respect to the bar in accordance with ASTM D790 within a week of the preparation of the bar.", "In this specification, the melding point tm of the polypropylene resin (X) as a base resin is, as shown in FIG.", "3, measured in the following manner: 1 mg or more and 10 mg or less of the polypropylene resin is heated from 40° C. to 220° C. at a rate of 10° C./min.", "and thereafter cooled from 220° C. to 40° C. at a rate of 10° C./min.", "and again heated from 40° C. to 220° C. at a rate of 10° C./min.", "with the use of a differential scanning calorimeter DSC to obtain a DSC curve; and the melting peak temperature (tm in FIG.", "3) on the DSC curve in the second temperature rise is used as the melting point of the polypropylene resin (X).", "Furthermore, the melt end temperature tf denotes the temperature at which the high-temperature-side tail of the melting peak in the second temperature rise meets the base line at the high-temperature side.", "It is noted that, although FIG.", "3 shows an example of one melting peak, two melting peaks are likely to appear as shown in FIG.", "4 when the amount of the high density polyethylene resin (II) is increased.", "For example, in a case where a high density polyethylene resin (II) having a melting point of 130° C. is added, a melting peak resulting from the high density polyethylene resin (II) may appear at or near 130° C. in addition to one melting peak resulting from the polypropylene resin (I) as shown in FIG.", "3.This results in two melting peaks in total.", "In such a case where two melting peaks appear on the DSC curve in the second temperature rise, the temperature at the melting peak with greater heat absorption quantity may be used as “tm”.", "The melting point of the polypropylene resin (X) for use in one or more embodiments of the present invention is preferably 145° C. or above and 165° C. or below, more preferably 148° C. or above and 160° C. or below, even more preferably 148° C. or above and 158° C. or below, particularly preferably 148° C. or above and 155° C. or below.", "In a case where the melting point of the polypropylene resin (X) is below 145° C., an in-mold expanded molded product obtained through in-mold foaming molding of the resulting expanded particles tends to have insufficient compressive strength.", "In a case where the melting point is above 165° C., the mold heating pressure in in-mold foaming molding tends to become too high and the expanded particles tend to be unmoldable with a usual in-mold foaming molding apparatus resistant to pressure of up to 0.4 MPa (gage pressure).", "1-4.Foam Nucleating Agent The polypropylene resin (X) in the expanded polypropylene resin particles in accordance with one or more embodiments of the present invention preferably contains no or one foam nucleating agent.", "Specific examples of the foam nucleating agent for use in one or more embodiments of the present invention include silica (silicon dioxide), silicate, alumina, diatomaceous earth, calcium carbonate, magnesium carbonate, calcium phosphate, feldspar, apatite, and barium sulfate.", "Examples of silicate include talc, magnesium silicate, kaolin, halloysite, dickite, aluminum silicate, and zeolite.", "It is preferable that none or one of such foam nucleating agents be contained.", "The polypropylene resin (X) of one or more embodiments of the present invention, which contains no or one foam nucleating agent, brings about an effect such that the molding cycle in a production method of an in-mold expanded molded product becomes short and that the in-mold expanded molded product has better dimensional accuracy.", "In comparison with the case in which two or more foam nucleating agents are contained, the case where no or one foam nucleating agent is contained does not cause, in a production method of an in-mold expanded molded product, non-uniformity of cell nucleation that would occur due to different kinds of foam nucleating agent and therefore the cell diameter obtained is uniform and the molding cycle and the dimensions of a molded product are less affected.", "In view of uniformity of cell diameters of the resulting expanded particles, the amount of the foam nucleating agent in one or more embodiments of the present invention is preferably 0.005 parts by weight or more and 2 parts by weight or less, more preferably 0.01 parts by weight or more and 1 part by weight or less, even more preferably 0.03 parts by weight or more and 0.5 parts by weight or less, with respect to 100 parts by weight of the polypropylene resin (X).", "1-5.Additives In one or more embodiments of the present invention, some additive(s) may be added to the polypropylene resin (X), provided that the effects of one or more embodiments of the present invention are not impaired.", "Examples of the additives include colorants, hydrophilic compounds, antistatic agents, flame retarders, and antioxidants.", "A colorant for use in one or more embodiments of the present invention is not limited to a particular kind, provided that the effects of one or more embodiments of the present invention are not impaired.", "Examples of the colorant for use in one or more embodiments of the present invention include carbon black, ultramarine blue, cyanine pigment, azo pigment, quinacridone pigment cadmium yellow, chrome oxide, iron oxide, perylene pigment, and anthraquinone pigment.", "One of these colorants may be used individually or two or more of them may be used in combination.", "Of those listed above, the addition of carbon black generally tends to cause the expanded polypropylene resin particles to have finer cell diameter.", "However, in regard to the expanded polypropylene resin particles obtained in one or more embodiments of the present invention, the cell diameter is prevented from becoming fine or becoming too fine.", "Therefore, the addition of carbon black in one or more embodiments of the present invention is preferred.", "The amount of carbon black in one or more embodiments of the present invention is preferably 0.1 parts by weight or more and 10 parts by weight or less, more preferably 0.5 parts by weight or more and 8 parts by weight or less, even more preferably 1 part by weight or more and 6 parts by weight or less, with respect to 100 parts by weight of the polypropylene resin (X).", "Carbon black contained in an amount less than 0.1 parts by weight tends to result in weak color of the resulting expanded particles.", "Carbon black contained in an amount more than 10 parts by weight tends to hinder the effect of increasing cell diameter of the resulting expanded particles.", "In one or more embodiments of the present invention, the addition of a hydrophilic compound is preferred in that it facilitates an improvement in expansion ratio of the expanded polypropylene resin particles and that an effect of one or more embodiments of the present invention, i.e., the effect of increasing the cell diameter of the resulting expanded particles, is more readily achieved.", "Examples of a hydrophilic compound for use in one or more embodiments of the present invention include water-absorbing organic compounds such as glycerin, diglycerin, polyethylene glycol (PEG), glycerin fatty acid ester, melamine, isocyanuric acid, and melamine-isocyanuric acid condensate.", "The amount of a hydrophilic compound contained in one or more embodiment of the present invention is preferably 0.01 parts by weight or more and 5 parts by weight or less, more preferably 0.1 parts by weight or more and 2 parts by weight or less, with respect to 100 parts by weight of the polypropylene resin (X).", "If a hydrophilic compound is contained in an amount less than 0.01 parts by weight, there is a tendency that the effect of improving expansion ratio and the effect of increasing cell diameter are difficult to achieve in the resulting expanded particles.", "If a hydrophilic compound is contained in an amount more than 5 parts by weight, there is a tendency that the hydrophilic compound is difficult to diffuse uniformly in the polypropylene resin during the production of expanded particles.", "It is noted that some flame retarders and antioxidants have the ability to make finer the cell diameter of expanded polypropylene resin particles.", "If any of such flame retarders and antioxidants is to be used, the amount thereof is preferably selected in a manner such that the effects of one or more embodiments of the present invention are not significantly impaired.", "In one or more embodiments of the present invention, an additive(s) such as a colorant, a hydrophilic compound, an antistatic agent, a flame retarder, and/or an antioxidant may be added directly to the polypropylene resin (X).", "Alternatively, the following arrangement may be employed: a masterbatch resin is prepared in advance by adding, at high concentration, the additive(s) to some other resin; and the masterbatch resin is added to the polypropylene resin (X).", "A resin for use in preparing a masterbatch resin is preferably a polypropylene resin.", "It is most preferable that the masterbatch resin be prepared using the polypropylene resin (I) which constitutes the polypropylene resin (X) serving as a base resin of the expanded polypropylene resin particles.", "2.Method for Producing Expanded Polypropylene Resin Particles A method for producing expanded polypropylene resin particles in accordance with one or more embodiments of the present invention is a method for producing expanded polypropylene resin particles containing a polypropylene resin (X) as a base resin.", "The polypropylene resin (X) contains a polypropylene resin (I) in an amount of 85 to 99 weight % and a high density polyethylene resin (II) in an amount of 1 to 15 weight % so that the total amount of the polypropylene resin (I) and the high density polyethylene resin (II) is 100 weight %.", "The polypropylene resin (I) has a melt flow rate of 3 g/10 min.", "or more and 20 g/10 min.", "or less and a melting point of 145° C. or above and 165° C. or below.", "The high density polyethylene resin (II) has a density of 0.93 to 0.97 g/cm3 and a melt flow rate of 0.1 g/10 min.", "or more and 15 g/10 min.", "or less.", "No or one foam nucleating agent is contained in the polypropylene resin (X).", "A hydrophilic compound is contained in the polypropylene resin (X).", "The expanded polypropylene resin particles have an expansion ratio of 10 times or greater and 40 times or less, an average cell diameter of 100 μm or greater and 250 μm or less, and an open cell ratio of 0% or greater and 10% or less.", "The method includes: obtaining a dispersion slurry by placing water, an inorganic gas-based foaming agent, and polypropylene resin particles composed of the polypropylene resin (X) in a pressure-resistant container and dispersing the polypropylene resin particles with stirring, and increasing temperature and pressure; and thereafter releasing the dispersion slurry from the pressure-resistant container to a region having a pressure lower than the internal pressure of the pressure-resistant container to expand the polypropylene resin particles.", "2-1.Method of Producing Polypropylene Resin Particles In production of expanded polypropylene resin particles in accordance with one or more embodiments of the present invention, a method of producing polypropylene resin particles is performed first, for example.", "Examples of the method of producing polypropylene resin particles include a method in which an extruder is used.", "Specifically, for example, the polypropylene resin (I) and the high density polyethylene resin (II) may blended with some other additive(s) such as a colorant, a hydrophilic compound, and/or the like depending on need and the blend may be fed into an extruder and melted and kneaded, extruded through a die, and then cooled, and thereafter chopped with the use of a cutter into particles in a desired shape such as a columnar shape, an ellipsoidal shape, a spherical shape, a cubic shape, and/or a rectangular parallelepiped shape.", "Alternatively, the polypropylene resin (I) and the high density polyethylene resin (II) may be fed into an extruder and some other additive(s) such as a colorant, a hydrophilic compound, and/or the like may be fed downstream of the resin inlet of the extruder depending on need to cause mixing inside the extruder, such that the polypropylene resin (I), the high density polyethylene resin (II), and the additive(s) are melted and kneaded.", "The weight of each of the polypropylene resin particles thus obtained from the polypropylene resin (X) is preferably 0.2 mg per particle or greater and 10 mg per particle or less, more preferably 0.5 mg per particle or greater and 5 mg per particle or less.", "If the weight of each of the polypropylene resin particles is less than 0.2 mg per particle, then handleability tends to decrease in the production of expanded particles.", "If the weight is greater than 10 mg per particle, then a mold-filling property for fine structures tends to decrease in a process of molding the resulting expanded particles through in-mold foaming.", "2-2.Method for Producing Expanded Polypropylene Resin Particles Expanded polypropylene resin particles in accordance with one or more embodiments of the present invention can be produced from the thus-obtained polypropylene resin particles.", "Preferred examples of a method of producing the expanded polypropylene resin particles in accordance with one or more embodiments of the present invention include a method of producing expanded polypropylene resin particles in an aqueous dispersion system by performing the following expansion process: polypropylene resin particles and a foaming agent such as carbon dioxide are dispersed in an aqueous dispersion medium in a pressure-resistant container; the pressure-resistant container is heated to a temperature equal to or above the softening temperature of the polypropylene resin particles and is subjected to pressure; and thereafter the temperature and the pressure are maintained for a certain period of time; and thereafter the dispersion slurry is released from the pressure-resistant container to a region having a pressure lower than the internal pressure of the pressure-resistant container.", "The following is a specific example.", "(1) Polypropylene resin particles, an aqueous dispersion medium, and, as necessary, a dispersing agent, for example, are placed into a pressure-resistant container.", "Then, while the resultant mixture is stirred, the inside of the pressure-resistant container is vacuumed as necessary.", "Then, a foaming agent having a pressure of 1 MPa (gage pressure) or more and 2 MPa (gage pressure) or less is introduced into the pressure-resistant container, and then the pressure-resistant container is heated to a temperature equal to or above the softening temperature of the polypropylene resin.", "By heating, the internal pressure of the pressure-resistant container rises to approximately 2 MPa (gage pressure) or more and 5 MPa (gage pressure) or less.", "If needed, an additional foaming agent is introduced at around a foaming temperature to achieve a desired foaming pressure, the temperature is further adjusted, and thereafter the temperature and pressure are maintained for a certain period of time, and then the dispersion slurry is released from the pressure-resistant container into a region having a pressure lower than the internal pressure of the pressure-resistant container, whereby expanded polypropylene resin particles are obtained.", "Note that, in this specification, the “region having a pressure lower than the internal pressure of a pressure-resistant container” may be referred to as “low-pressure region”.", "The following is another preferred arrangement that may be employed.", "(2) Polypropylene resin particles, an aqueous dispersion medium, and, as necessary, a dispersing agent, for example, are placed into a pressure-resistant container.", "Then, while the resultant mixture is stirred, the inside of the pressure-resistant container is vacuumed as necessary.", "Then, while the pressure-resistant container is heated to a temperature equal to or above the softening temperature of the polypropylene resin, a foaming agent is introduced into the pressure-resistant container.", "The expanded polypropylene resin particles may alternatively be obtained by further adjusting the temperature and thereafter maintaining the temperature for a certain period of time, and then releasing the dispersion slurry from the pressure-resistant container into a region having a pressure lower than the internal pressure of the pressure-resistant container.", "The following is a further preferred arrangement that may be employed.", "(3) Polypropylene resin particles, an aqueous dispersion medium, and, as necessary, a dispersing agent, for example, are placed into a pressure-resistant container.", "Then, the pressure-resistant container is heated to a temperature around a foaming temperature.", "A foaming agent is further introduced into the pressure-resistant container, temperature is adjusted to the foaming temperature, and the temperature is maintained for a certain period of time.", "Then, the dispersion slurry is released from the pressure-resistant container into a region having a pressure lower than the internal pressure of the pressure-resistant container, so that polypropylene polyolefin resin particles are obtained.", "Note that the expansion ratio of expanded particles can be adjusted by: adjusting a pressure-releasing speed during foaming by increasing the internal pressure of the pressure-resistant container through injecting carbon dioxide, nitrogen, air, or a substance used as a foaming agent, into the pressure-resistant container before the dispersion slurry is released into the low-pressure region; and controlling the pressure through introducing carbon dioxide, nitrogen, air, or a substance used as a foaming agent, into the pressure-resistant container also while the dispersion slurry is being released into the low-pressure region.", "The expansion ratio of the expanded polypropylene resin particles of one or more embodiments of the present invention is not particularly limited, and is preferably 5 times or more to 60 times or less.", "If the expansion ratio of the expanded polypropylene resin particles is less than 5 times, then weight reduction of an in-mold expanded molded product obtained through in-mold foaming molding of the resulting expanded particles tends to be insufficient.", "If the expansion ratio of the expanded polypropylene resin particles is more than 60 times, then mechanical strength of the in-mold expanded molded product tends to be impractical.", "The average cell diameter of the expanded polypropylene resin particles in accordance with one or more embodiments of the present invention is preferably 100 μm or greater and 250 μm or less, more preferably 110 μm or greater and 240 μm or less, even more preferably 120 μm or greater and 230 μm or less.", "If the average cell diameter of the expanded polypropylene resin particles is less than 100 μm, there is a tendency that a polypropylene resin in-mold expanded molded product obtained through in-mold foaming molding of the resulting expanded particles has deteriorated surface appearance.", "If the average cell diameter is greater than 250 μm, there is a tendency that the uniformity of the cell diameters of the expanded particles decreases and also there is a tendency that the fusibility of the in-mold expanded molded product partially deteriorates and that the surface appearance of the polypropylene resin in-mold expanded molded product also deteriorates.", "The expanded polypropylene resin particles in accordance with one or more embodiments of the present invention has an open cell ratio of preferably 0% or greater and 10% or less, more preferably 0% or greater and 9% or less.", "If the open cell ratio of the expanded polypropylene resin particles is greater than 10%, there is a tendency that the resulting expanded particles readily shrink when molded through in-mold foaming and thus the resulting in-mold expanded molded product has poor surface appearance and reduced compressive strength.", "In regard to the DSC curve obtained by differential scanning calorimetry (DSC) in which the temperature of the expanded polypropylene resin particles in accordance with one or more embodiments of the present invention is raised at a heating rate of 10° C./min., there may be the following cases depending on the amount of the high density polyethylene (II): a case in which two melting peaks appear and accordingly there are at least two melting heat quantities (low-temperature-side melting heat quantity (Ql) and high-temperature-side melting heat quantity (Qh)) as shown in FIG.", "1; and a case in which three melting peaks appear in total including two melting peaks resulting from the polypropylene resin (I) and also a melting peak resulting from the high density polyethylene resin (II) which appears at or near 130° C. as shown in FIG.", "2.The expanded polypropylene resin particles in accordance with one or more embodiments of the present invention can be obtained easily by the earlier-described method for producing expanded polypropylene resin particles in an aqueous dispersion system, in which the foaming temperature (temperature inside the pressure-resistant container during foaming) is adjusted as needed to an appropriate value and the temperature is maintained for a certain period of time.", "Specifically, assuming that the melting point of the polypropylene resin (X) as a base resin is represented as “tm” and the melt end temperature of the polypropylene resin (X) is represented as “tf”, normally the foaming temperature is preferably 80° C. or above and below tf(° C.).", "At a temperature below 80° C., there is a tendency that the polypropylene resin (X) does not soften much and therefore does not foam when producing expanded particles.", "At a temperature above tf(° C.), there is a tendency that the polypropylene resin (X) ends up melting and aggregating in the pressure-resistant container in the production of expanded particles.", "A preferred range of the foaming temperature differs depending on what foaming agent is selected, because the plasticizing effect, which is to facilitate the softening of the polypropylene resin, differs depending on the foaming agent.", "In a case of carbon dioxide for example, the foaming temperature is preferably tm-10(° C.) or above and below tf(° C.), more preferably tm-8(° C.) or above and below tf(° C.), even more preferably tm-5(° C.) or above and tf-2(° C.) or below.", "In the method for producing expanded polypropylene resin particles, the temperature inside the pressure-resistant container at the time of foaming is maintained preferably for 1 minute or longer and 120 minutes or shorter, more preferably for 5 minutes or longer and 60 minutes or shorter, in view of controlling the crystallinity condition of the polypropylene resin and in view of production cycle.", "In one or more embodiments of the present invention, the entire melting heat quantity (Q), the low-temperature-side melting heat quantity (Ql), and the high-temperature-side melting heat quantity (Qh) of expanded polypropylene resin particles are defined as follows (with reference to FIGS.", "1 and 2).", "On the DSC curve obtained, the entire melting heat quantity (Q=Ql+Qh), which is the sum of the low-temperature-side melting heat quantity (Ql) and the high-temperature-side melting heat quantity (Qh), is represented by the area enclosed by line segment A-B and the DSC curve.", "Line segment A-B connects point A (heat absorption quantity at 80° C.) and point B (heat absorption quantity at the temperature at which high-temperature-side melting ends).", "The low-temperature-side melting heat quantity (Ql) is represented by the area enclosed by line segment A-D, line segment C-D, and the DSC curve, and the high-temperature-side melting heat quantity (Qh) is represented by the area enclosed by line segment B-D, line segment C-D, and the DSC curve.", "Point C is the point at which the heat absorption quantity is smallest between the following two melting heat quantity regions: the low-temperature-side melting heat quantity (Ql) and the high-temperature-side melting heat quantity (Qh), on the DSC curve.", "Point D is the intersection of line segment A-B and a line that extends from point C in a direction perpendicular to line segment A-B.", "It is noted that, in a case where three melting peaks appear as illustrated in FIG.", "2, there are two points that can serve as the smallest heat absorption quantity between two adjacent melting heat quantity regions.", "In such a case, the point at the high-temperature side is used as point C. In regard to the expanded polypropylene resin particles in accordance with one or more embodiments of the present invention, the percentage of the high-temperature-side melting heat quantity (Qh) [={Qh/(Ql+Qh)}×100(%)] (hereinafter also referred to as “high-temperature heat quantity ratio”) is preferably 10% or greater and 50% or less, more preferably 15% or greater and 40% or less, even more preferably 15% or more and 30% or less.", "If the high-temperature heat quantity ratio is less than 10%, the compressive strength of an in-mold expanded molded product obtained through in-mold foaming molding of the resulting expanded particles is low and the practical rigidity tends to decrease.", "If the high-temperature heat quantity ratio is greater than 50%, there is a tendency that the compressive strength of the in-mold expanded molded product becomes high but the expandability of the expanded polypropylene resin particles is too low and that the in-mold expanded molded product as a whole is poorly fused or a high molding pressure is required for fusion.", "The average cell diameter of the expanded polypropylene resin particles also tends to become small.", "The high-temperature heat quantity ratio can be adjusted as appropriate by, for example, adjusting the time for which the earlier-described temperature inside the pressure-resistant container is maintained (i.e.", "time from when the temperature inside the pressure-resistant container reaches a desired temperature to when foaming starts), the foaming temperature (which is a temperature during foaming and which may or may not be equal to the above temperature inside the pressure-resistant container), foaming pressure (pressure during foaming), and/or the like, in the production of expanded particles.", "In general, the high-temperature heat quantity ratio or the heat quantity at the high-temperature-side melting peak tends to become large when the time for which the temperature is maintained is increased, foaming temperature is lowered, or/and foaming pressure is lowered.", "Because of these factors, conditions to obtain a desired percentage of high-temperature-side melting heat quantity can be easily found by conducting several experiments in which the time for which the temperature is maintained, the foaming temperature, or/and the foaming pressure is/are systematically changed.", "Note that the foaming pressure can be adjusted by adjusting the amount of a foaming agent.", "In one or more embodiments of the present invention, the pressure-resistant container into which the polypropylene resin particles are dispersed is not limited to any particular one, provided that the pressure-resistant container is resistant to the pressure inside the container and the temperature inside the container during production of the expanded particles.", "Examples of the pressure-resistant container include autoclave-type pressure-resistant containers.", "An aqueous dispersion medium for use in one or more embodiments of the present invention is preferably water alone, in view of the environmental load that the waste water would impose.", "Alternatively, the aqueous dispersion medium may be a dispersion medium obtained by adding methanol, ethanol, ethylene glycol, glycerin, or the like to water.", "In a case a hydrophilic compound is contained in one or more embodiments of the present invention, the water in the aqueous dispersion medium serves also as a foaming agent.", "The water serving also as a foaming agent contributes to an improvement in expansion ratio of the resulting expanded particles.", "In one or more embodiments of the present invention, normally the aqueous dispersion medium is used preferably in an amount of preferably 100 parts by weight or more and 500 parts by weight or less with respect to 100 parts by weight of the polypropylene resin particles, for the polypropylene resin particles to be well dispersed in the aqueous dispersion medium.", "Examples of the foaming agent for use in one or more embodiments of the present invention include inorganic foaming agents such as air, nitrogen, carbon dioxide, and water.", "The inorganic foaming agents are more advantageous than organic foaming agents in that the inorganic foaming agents have a low global warming potential and impose smaller environmental load and that they do not require explosion-proof facilities and thus the facility becomes less costly.", "Of the inorganic foaming agents, carbon dioxide is particularly preferred, because carbon dioxide has moderately high plasticizing effect and readily improves foamability when obtaining expanded polypropylene resin particles.", "In a case where an inorganic foaming agent containing carbon dioxide and/or water, especially an inorganic foaming agent containing carbon dioxide, is used in the earlier-described method for producing expanded polypropylene resin particles with the use of an aqueous dispersion system, the average cell diameter is generally likely to become smaller than the cases in which a saturated hydrocarbon is used.", "However, according to one or more embodiments of the present invention, even in the case where the foaming agent is an inorganic foaming agent that contains carbon dioxide and/or water and thus the average cell diameter becomes relatively smaller than conventional cases in which a saturated hydrocarbon is used, the in-mold expanded molded product is likely to have improved surface appearance and the effects of one or more embodiments of the present invention are readily achieved.", "Therefore, using an inorganic foaming agent is preferred.", "In one or more embodiments of the present invention, it is preferable to use a dispersing agent or/and a dispersion auxiliary agent in an aqueous dispersion medium in order to prevent polypropylene resin particles from agglomerating.", "Examples of the dispersing agent for use in one or more embodiments of the present invention include inorganic dispersion agents such as tertiary calcium phosphate, tertiary magnesium phosphate, basic magnesium carbonate, calcium carbonate, barium sulfate, kaolin, talc, and clay.", "These inorganic dispersion agents may be used individually, or two or more of these inorganic dispersion agents may be used in combination.", "Examples of the dispersion auxiliary agent for use in one or more embodiments of the present invention include: anionic surfactants of carboxylate type; anionic surfactants of sulfonate type such as alkyl sulfonate, n-paraffin sulfonate salt, alkyl benzene sulfonate, alkyl naphthalene sulfonate, and sulfosuccinate; anionic surfactants of sulfate ester type such as sulfonated oil, alkyl sulfate salt, alkyl ether sulfate, and alkyl amide sulfate; and anionic surfactants of phosphate ester type such as alkyl phosphate, polyoxyethylene phosphate, and alkyl allyl ether sulfate.", "These dispersion auxiliary agents may be used individually or two or more of these dispersion auxiliary agents may be used in combination.", "Of these, the following are preferably used in combination: at least one dispersing agent selected from the group consisting of tertiary calcium phosphate, tertiary magnesium phosphate, barium sulfate, and kaolin; and a dispersion auxiliary agent which is n-paraffin sodium sulfonate.", "The amounts of the dispersing agent and the dispersion auxiliary agent vary depending on their type and the type and amount of polypropylene resin particles used.", "Normally, with respect to 100 parts by weight of polypropylene resin particles, the dispersing agent is preferably used in an amount of 0.2 parts by weight or more and 3 parts by weight or less, and the dispersion auxiliary agent is preferably used in an amount of 0.001 parts by weight or more and 0.1 parts by weight or less.", "The process of thus obtaining expanded polypropylene resin particles from polypropylene resin particles may be referred to as “first-step expansion process”, and the expanded polypropylene resin particles thus obtained may be referred to as “first-step expanded particles”.", "The expansion ratio of the resulting first-step expanded particles may not reach 10 times, depending on the type of foaming agent in the production.", "In such a case, expanded polypropylene resin particles whose expansion ratio is improved in comparison with that of first-step expanded particles can be obtained by applying an internal pressure to the first-step expanded particles by impregnation of inorganic gas (e.g.", "air, nitrogen, carbon dioxide) and then bringing the first-step expanded particles into contact with steam having a certain pressure.", "The process of thus further foaming the expanded polypropylene resin particles so as to obtain expanded polypropylene resin particles having a higher expansion ratio may be referred to as “second-step expansion process”.", "Expanded polypropylene resin particles thus obtained through the second-step expansion process may be referred to as “second-step expanded particles”.", "In one or more embodiments of the present invention, the pressure of steam in the second-step expansion process is controlled at preferably 0.04 MPa (gage pressure) or greater and 0.25 MPa (gage pressure) or less, more preferably 0.05 MPa (gage pressure) greater and 0.15 MPa (gage pressure) or less, in consideration of the expansion ratio of the second-step expanded particles.", "If the pressure of steam in the second-step expansion process is less than 0.04 MPa (gage pressure), then the expansion ratio of the resulting second-step expanded particles does not tend to improve.", "If the pressure is greater than 0.25 MPa (gage pressure), then the resulting second-step expanded particles tend to agglomerate and to become impossible to use the second-step expanded particles for subsequent in-mold foaming molding.", "The internal pressure of the inorganic gas to be impregnated into the first-step expanded particles, that is, the internal pressure of expanded particles (absolute pressure), is desirably varied as appropriate in consideration of the expansion ratio of the second-step expanded particles and steam pressure in the second-step expansion process, and is preferably 0.2 MPa or greater (absolute pressure) and 0.6 MPa or less (absolute pressure).", "If the internal pressure (absolute pressure) of the expanded particles is less than 0.2 MPa (absolute pressure), then steam having a high pressure is necessary to improve the expansion ratio, so that the second-step expanded particles tend to agglomerate.", "If the internal pressure (absolute pressure) of the expanded particles is greater than 0.6 MPa (absolute pressure), then the second-step expanded particles tend to become an open-cell foam.", "In such a case, rigidity, such as compressive strength, of an in-mold expanded molded product obtained through in-mold foaming molding of the resulting expanded particles tends to decrease.", "The expanded polypropylene resin particles in accordance with one or more embodiments of the present invention may be either first-step expanded particles produced through a first-step expansion process or second-step expanded particles produced through a second-step expansion process.", "The method for producing expanded polypropylene resin particles in accordance with one or more embodiments of the present invention may include a first-step expansion process or may include a second-step expansion process in addition to the first-step expansion process.", "It is noted that the expanded polypropylene resin particles of one or more embodiments of the present invention exclude styrene-modified expanded polypropylene resin particles obtained through a process of impregnating polypropylene resin particles with styrene and polymerizing them.", "Although the reasons therefore are unknown, the effects of one or more embodiments of the present invention are not noticeable in the case of styrene-modified expanded polypropylene resin particles.", "3.Polypropylene Resin in-Mold Expanded Molded Product and Method for Producing Polypropylene Resin in-Mold Expanded Molded Product A polypropylene resin in-mold expanded molded product in accordance with one or more embodiments of the present invention is preferably obtained by the following method for producing a polypropylene resin in-mold expanded molded product from the expanded polypropylene resin particles described earlier in the “1.Expanded polypropylene resin particles” section.", "Alternatively, a polypropylene resin in-mold expanded molded product in accordance with one or more embodiments of the present invention is preferably obtained by the following method for producing a polypropylene resin in-mold expanded molded product from the expanded polypropylene resin particles produced by the method described earlier in the “2.Method for producing expanded polypropylene resin particles” section.", "The expanded polypropylene resin particles in accordance with one or more embodiments of the present invention can be made into a polypropylene resin in-mold expanded molded product by a conventionally known in-mold foaming molding method.", "Examples of an in-mold foaming molding method include: A) a method by which expanded polypropylene resin particles are pressured with an inorganic gas such as air, nitrogen, or carbon dioxide so that the expanded polypropylene resin particles are impregnated with the inorganic gas and have a certain internal pressure, and thereafter the expanded polypropylene resin particles are filled into a mold and heated with steam to fuse together; B) a method by which expanded polypropylene resin particles are compressed with gas pressure and are filled into a mold, and heated with steam to fuse together utilizing the recovery force of the expanded polypropylene resin particles; and C) a method by which expanded polypropylene resin particles are filled into a mold without performing any particular pretreatment and heated with steam to fuse together.", "In the method for producing a polypropylene resin in-mold expanded molded product in accordance with one or more embodiments of the present invention, it is preferable that the molding cycle be short.", "Specifically, it is preferable that molding cycle time reduction, which will be described later in detail in Examples, be large in value.", "The molding cycle time reduction in the method for producing a polypropylene resin in-mold expanded molded product in accordance with one or more embodiments of the present invention is not particularly limited, but is preferably 6% or greater, more preferably 7% or greater, even more preferably 8% or greater, particularly preferably 10% or greater.", "The upper limit of the molding cycle time reduction in accordance with one or more embodiments of the present invention is not particularly limited, provided that the resulting in-mold expanded molded product has good surface appearance, good dimensional accuracy, and the like.", "The dimensional accuracy of a polypropylene resin in-mold expanded molded product in accordance with one or more embodiments of the present invention is represented by the percentage of shrinkage of the polypropylene resin in-mold expanded molded product, which will be described later in detail in Examples.", "The percentage of shrinkage of the polypropylene resin in-mold expanded molded product in accordance with one or more embodiments of the present invention is preferably 0% or greater and less than 2.6%, more preferably 0% or greater and less than 2.3%, even more preferably 0% or greater and less than 2%, from the viewpoint of usage of the in-mold expanded molded product.", "The polypropylene resin in-mold expanded molded product in accordance with one or more embodiments of the present invention has a density of preferably 10 g/L or greater and 60 g/L or less, more preferably 11 g/L or greater and 59 g/L or less.", "When the density of the polypropylene resin in-mold expanded molded product is 10 g/L or greater, an obtained effect is that the weight reduction of the resulting in-mold expanded molded product is satisfactory.", "When the density is 60 g/L or less, an obtained effect is that the in-mold expanded molded product has practical mechanical strength such as practical compressive strength.", "The compressive strength of the polypropylene resin in-mold expanded molded product in accordance with one or more embodiments of the present invention is represented by a 50%-strained compressive strength, which will be described later in detail in Examples.", "The 50%-strained compressive strength of the polypropylene resin in-mold expanded molded product in accordance with one or more embodiments of the present invention is preferably 0.22 MPa or greater, more preferably 0.23 MPa or greater, even more preferably 0.24 MPa or greater, from the viewpoint of usage of the in-mold expanded molded product.", "The upper limit of the 50%-strained compressive strength in accordance with one embodiment of the present invention is not particularly limited, provided that the in-mold expanded molded product has good surface appearance, good dimensional accuracy, and the like.", "The open cell ratio of the polypropylene resin in-mold expanded molded product in accordance with one or more embodiments of the present invention is not particularly limited, and is preferably 0% or greater and 10% or less from the viewpoint of the surface appearance and strength of the in-mold expanded molded product.", "The polypropylene resin in-mold expanded molded product in accordance with one or more embodiments of the present invention may be used in various applications such as not only car interior materials and car bumper core materials but also heat insulators, shock-absorbing packing materials, and returnable containers.", "As has been described, according to one or more embodiments of the present invention, the cell diameter of expanded polypropylene resin particles is prevented from becoming fine or becoming too fine, and therefore the expandability of expanded particles does not tend to decrease even with a relatively low molding pressure in the method for producing an in-mold expanded molded product.", "This provides a polypropylene resin in-mold expanded molded product having excellent surface appearance.", "Furthermore, the polypropylene resin in-mold expanded molded product obtained from the expanded polypropylene resin particles containing as a base resin a polypropylene resin (X) having a flexural modulus of 1200 MPa or greater and 1700 MPa or less, more preferably 1200 MPa or greater and 1550 MPa or less, tends to have high compressive strength, and therefore is suitable for use in applications that require high rigidity such as bumpers and in applications that require durability such as returnable containers.", "In addition, a more lightweight polypropylene resin in-mold expanded molded product can be obtained.", "One or more embodiments of the present invention may be arranged as below.", "[1] An expanded polypropylene resin particle containing a polypropylene resin (X) as a base resin, the polypropylene resin (X) containing a polypropylene resin (I) in an amount of 85 to 99 weight % and a high density polyethylene resin (II) in an amount of 1 to 15 weight % so that the total amount of the polypropylene resin (I) and the high density polyethylene resin (II) is 100 weight %, and the polypropylene resin (I) having a melt flow rate of 3 g/10 min.", "or more and 20 g/10 min.", "or less and a melting point of 145° C. or above and 165° C. or below, and the high density polyethylene resin (II) having a density of 0.93 to 0.97 g/cm3 and a melt flow rate of 0.1 g/10 min.", "or more and 15 g/10 min.", "or less, wherein no or one foam nucleating agent is contained in the polypropylene resin (X), wherein a hydrophilic compound is contained in the polypropylene resin (X), and wherein the expanded polypropylene resin particle has an expansion ratio of 10 times or greater and 40 times or less, an average cell diameter of 100 μm or greater and 250 μm or less, and an open cell ratio of 0% or greater and 10% or less.", "[2] The expanded polypropylene resin particle according to [1], wherein the melting point of the polypropylene resin (I) is 148° C. or above and 160° C. or below.", "[3] The expanded polypropylene resin particle according to [1] or [2], wherein the melting point of the high density polyethylene resin (II) is 125° C. or above and 135° C. or below.", "[4] The expanded polypropylene resin particle according to any one of [1] to [3], wherein the melting point of the high density polyethylene resin (II) is 125° C. or above and 130° C. or below.", "[5] The expanded polypropylene resin particle according to any one of [1] to [4], wherein the high density polyethylene resin (II) has a flexural modulus of 800 MPa or greater and 1600 MPa or less.", "[6] The expanded polypropylene resin particle according to any one of [1] to [5], wherein the amount of the no or one foam nucleating agent is 0.005 parts by weight or more and 2 parts by weight or less with respect to 100 parts by weight of the polypropylene resin (X).", "[7] The expanded polypropylene resin particle according to any one of [1] to [6], wherein the hydrophilic compound is at least one selected from the group consisting of melamine, glycerin, diglycerin, and polyethylene glycol.", "[8] A method for producing expanded polypropylene resin particles containing a polypropylene resin (X) as a base resin, the polypropylene resin (X) containing a polypropylene resin (I) in an amount of 85 to 99 weight % and a high density polyethylene resin (II) in an amount of 1 to 15 weight % so that the total amount of the polypropylene resin (I) and the high density polyethylene resin (II) is 100 weight %, and the polypropylene resin (I) having a melt flow rate of 3 g/10 min.", "or more and 20 g/10 min.", "or less and a melting point of 145° C. or above and 165° C. or below, and the high density polyethylene resin (II) having a density of 0.93 to 0.97 g/cm3 and a melt flow rate of 0.1 g/10 min.", "or more and 15 g/10 min.", "or less, wherein no or one foam nucleating agent is contained in the polypropylene resin (X), wherein a hydrophilic compound is contained in the polypropylene resin (X), and wherein the expanded polypropylene resin particles have an expansion ratio of 10 times or greater and 40 times or less, an average cell diameter of 100 μm or greater and 250 μm or less, and an open cell ratio of 0% or greater and 10% or less, the method including: obtaining a dispersion slurry by placing water, an inorganic gas-based foaming agent, and polypropylene resin particles composed of the polypropylene resin (X) in a pressure-resistant container and dispersing the polypropylene resin particles with stirring, and increasing temperature and pressure; and thereafter releasing the dispersion slurry from the pressure-resistant container to a region having a pressure lower than the internal pressure of the pressure-resistant container to expand the polypropylene resin particles.", "[9] The method according to [8], wherein the inorganic gas-based foaming agent is carbon dioxide.", "[10] The method according to [8] or [9], wherein the melting point of the polypropylene resin (I) is 148° C. or above and 160° C. or below.", "[11] The method according to any one of [8] to [10], wherein the melting point of the high density polyethylene resin (II) is 125° C. or above and 135° C. or below.", "[12] The method according to any one of [8] to [11], wherein the melting point of the high density polyethylene resin (II) is 125° C. or above and 130° C. or below.", "[13] The method according to any one of [8] to [12], wherein the high density polyethylene resin (II) has a flexural modulus of 800 MPa or greater and 1600 MPa or less.", "[14] The method according to any one of [8] to [13], wherein the amount of the no or one foam nucleating agent is 0.005 parts by weight or more and 2 parts by weight or less with respect to 100 parts by weight of the polypropylene resin (X).", "[15] The method according to any one of [8] to [14], wherein the hydrophilic compound is at least one selected from the group consisting of melamine, glycerin, diglycerin, and polyethylene glycol.", "[16] A method for producing a polypropylene resin in-mold expanded molded product from the expanded polypropylene resin particle recited in any one of [1] to [7], wherein a molding cycle is 5 to 20% shorter than a molding cycle of a method for producing a polypropylene resin in-mold expanded molded product from an expanded polypropylene resin particle that contains, as a base resin, a polypropylene resin composed of the polypropylene resin (I) alone.", "[17] A polypropylene resin in-mold expanded molded product obtained from the expanded polypropylene resin particle recited in any one of [1] to [7], the polypropylene resin in-mold expanded molded product having a density of 10 g/L or greater and 60 g/L or less and an open cell ratio of 0 to 10%.", "EXAMPLES The following description will discuss one or more embodiments of the present invention in more detail with Examples and Comparative Examples.", "Note, however, that one or more embodiments of the present invention are not limited to these Examples.", "Substances used in Examples and Comparative Examples are as provided below.", "Polypropylene resin A [trial product from polypropylene resin manufacturer: propylene-ethylene random copolymer containing ethylene as comonomer in an amount of 2.5 weight %, having an MFR of 8 g/10 min., and having a melting point of 151° C.] Polypropylene resin B [trial product from polypropylene resin manufacturer: propylene-1-butene-ethylene random copolymer containing 1-butene as comonomer in an amount of 3.3 weight %, containing ethylene as comonomer in an amount of 1.1 weight %, having an MFR of 9 g/10 min., and having a melting point of 148° C.] Polypropylene resin C [trial product from polypropylene resin manufacturer: homopolypropylene having an MFR of 8 g/10 min.", "and having a melting point of 163° C.] The copolymer compositions of the polypropylene resins A, B, and C were quantitatively determined in the following manner.", "To a polypropylene resin (about 1 g), 50 g of xylene was added and heated at 120° C. so that the polypropylene resin dissolved, and separated into insoluble and soluble fractions with the use of a high-temperature centrifuge (a centrifuge available from KOKUSAN Co., LTd., H175) at 12000 rpm for 30 minutes.", "The obtained soluble fraction was cooled, and then centrifuged (at 12000 rpm for 30 minutes) to obtain an insoluble fraction.", "To 50 mg of the obtained insoluble fraction, 0.4 g of ortho-dichlorobenzene-d4 was added, and heated at 100° C. so that the insoluble fraction dissolved, and subjected to 13C-MNR spectrometry [INOVA AS600 available from VARIAN] at 98° C. In this way, the composition of a copolymer containing 1-butene and ethylene was quantified.", "High density polyethylene resin A [trial product from polyethylene resin manufacturer: MFR is 5 g/10 min., melting point is 130° C., and density is 0.953 g/cm3] High density polyethylene resin B [trial product from polyethylene resin manufacturer: MFR is 7 g/10 min., melting point is 133° C., and density is 0.963 g/cm3] High density polyethylene resin C [trial product from polyethylene resin manufacturer: MFR is 3 g/10 min., melting point is 135° C., and density is 0.968 g/cm3] High density polyethylene resin D [trial product from polyethylene resin manufacturer: MFR is 0.3 g/10 min., melting point is 126° C., and density is 0.944 g/cm3] Linear low-density polyethylene resin [trial product from polyethylene resin manufacturer: MFR is 2 g/10 min., melting point is 121° C., and density is 0.925 g/cm3] Talc [available from Hayashi-Kasei Co., Ltd.]: Talcan Powder PK-S Polyethylene glycol: PEG#300 available from Lion Corporation Carbon black: MCF88 (average particle diameter 18 nm) available from Mitsubishi Chemical Corporation The evaluations on Examples and Comparative Examples were performed in the following manner.", "(Measurement of Melting Point of Polypropylene Resin) The melting point tm of a polypropylene resin (X) was determined in the following manner: with the use of a differential scanning calorimeter DSC (available from Seiko Instruments Inc., model: DSC6200), 5 to 6 mg of the polypropylene resin was heated from 40° C. to 220° C. at a heating rate of 10° C./min.", "so that resin particles melted, and then cooled from 220° C. to 40° C. at a cooling rate of 10° C./min.", "so that crystallization occurred, and then again heated from 40° C. to 220° C. at a heating rate of 10° C./min.", "to obtain a DSC curve; and the temperature at the melting peak on the DSC curve obtained in the second temperature rise was used as the melting point (refer to “tm” in FIGS.", "3 and 4).", "It is noted that, in a case where two melting peaks appear on the DSC curve in the second temperature rise, the temperature at the melting peak with greater heat absorption quantity was used as “tm”.", "(Flexural Modulus of Polyethylene Resin or of Polypropylene Resin Particles) The flexural modulus was measured by: drying the earlier-described high density polyethylene resin or linear low-density polyethylene resin or the resulting polypropylene resin (X) at 80° C. for 6 hours; then preparing a bar having a thickness of 6.4 mm (a width of 12.7 mm and a length of 127 mm) by use of a 35 t injection molding machine at a cylinder temperature of 200° C. and a mold temperature of 30° C.; and performing a flexural test with respect to the bar in accordance with ASTM D790 within a week of the preparation of the bar.", "(Calculation of High-Temperature Heat Quantity Ratio of Expanded Polypropylene Resin Particles) The high-temperature heat quantity ratio [={Qh/(Ql+Qh)}×100(%)] was calculated based on the DSC curve (refer to FIGS.", "1 and 2) obtained with the use of a differential scanning calorimeter (available from Seiko Instruments Inc., model: DSC6200) by heating 5 mg to 6 mg of the expanded polypropylene resin particles from 40° C. to 220° C. at a heating rate of 10° C./min.", "As shown in FIG.", "1, the entire melting heat quantity (Q=Ql+Qh), which is the sum of the low-temperature-side melting heat quantity (Ql) and the high-temperature-side melting heat quantity (Qh), is, on the obtained DSC curve, represented by the area enclosed by line segment A-B and the DSC curve.", "Line segment A-B connects point A (heat absorption quantity at 80° C.) and point B (heat absorption quantity at the temperature at which high-temperature-side melting ends).", "The low-temperature-side melting heat quantity (Ql) is represented by the area enclosed by line segment A-D, line segment C-D, and the DSC curve, and the high-temperature-side melting heat quantity (Qh) is represented by the area enclosed by line segment B-D, line segment C-D, and the DSC curve.", "Point C is the point at which the heat absorption quantity is smallest between the following two melting heat quantity regions: the low-temperature-side melting heat quantity (Ql) and the high-temperature-side melting heat quantity (Qh), on the DSC curve.", "Point D is the intersection of line segment A-B and a line that extends from point C in a direction perpendicular to line segment A-B.", "It is noted that, in a case where three melting peaks appear as illustrated in FIG.", "2, there are two points that can serve as the smallest heat absorption quantity between two adjacent melting heat quantity regions.", "In such a case, the point at the high-temperature side was used as point C. (Average Cell Diameter of Expanded Polypropylene Resin Particles) An expanded polypropylene resin particle was cut substantially at the center while ensuring that foam membranes of the expanded polypropylene resin particle were not broken, and the cut surface was observed under a microscope [VHX digital microscope available from Keyence Corporation].", "On the image obtained under the microscope, a line segment representing a length of 1000 μm was drawn within the cut surface so as not to overlap the outer layer, the number (n) of cells on the line segment was counted, and the cell diameter was calculated using “1000/n (μm)”.", "The same operation was performed on ten expanded particles, and the mean of the cell diameters of the ten particles was used as the average cell diameter of the expanded polypropylene resin particles.", "(Open Cell Ratio of Expanded Polypropylene Resin Particles) The obtained expanded polypropylene resin particles were measured for volume Vc (cm3) with the use of an air comparison pycnometer (model 1000 available from TOKYO SCIENCE.)", "in accordance with the method defined in PROCEDURE C of ASTM D2856-87.After the measurement of Vc, these expanded polypropylene resin particles were entirely submerged in ethanol in a graduated cylinder, and the apparent volume Va (cm3) of the expanded polyethylene resin particles was determined from the difference in the liquid level of the graduated cylinder (submersion method).", "The open cell ratio of the expanded polypropylene resin particles was calculated using the following equation: Open cell ratio (%)=(Va−Vc)×100/Va (Expansion Ratio of Expanded Polypropylene Resin Particles) About 3 g or more and 10 g or less of the obtained expanded polypropylene resin particles were dried at 60° C. for 6 hours, and then subjected to conditioning indoors at 23° C. and at a humidity of 50%.", "Then, the weight w (g) of the expanded polypropylene resin particles was measured, and then the volume v (cm3) of the expanded polypropylene resin particles was found by the submersion method, and the absolute specific gravity (ρb=w/v) of the expanded polypropylene resin particles was obtained.", "Then, based on the ratio to the density (ρr) of the unfoamed polypropylene resin particles, the expansion ratio (K=ρr/ρb) was calculated.", "Note that in each of Examples and Comparative Examples below, the density (ρr) of unfoamed polypropylene resin particles (i.e., polypropylene resin particles) was 0.90 g/cm3.", "(Evaluation of Moldability of Polypropylene Resin in-Mold Expanded Molded Product) The moldability of a polypropylene resin in-mold expanded molded product in accordance with one or more embodiments of the present invention includes not only the surface appearance (flat portion), surface appearance (edge portion), and dimensional accuracy of the in-mold expanded molded product but also the minimum molding pressure (gage pressure) and molding cycle time reduction in the method for producing a polypropylene resin in-mold expanded molded product.", "With the use of a polypropylene foaming molding machine (available from DAISEN Co., Ltd., KD-345), a mold having a size of length 300 mm×width 400 mm×thickness 50 mm was filled with expanded polypropylene resin particles which had been prepared in advance so as to have an internal air pressure as shown in Table 1 and the expanded particles were heat molded by compressing by 10% in the thickness direction.", "In this way, a polypropylene resin in-mold expanded molded product was obtained.", "The polypropylene resin in-mold expanded molded product obtained was left at room temperature for 1 hour and then cured and dried in a thermostatic chamber at 75° C. for 3 hours, and brought out of the chamber and left at room temperature for 24 hours.", "Then, the fusibility, surface appearance, and dimensional accuracy of the molded product were evaluated and the density and 50%-strained compressive strength of the molded product were measured.", "It is noted that, in the method for producing an in-mold expanded molded product, molding was performed while changing the molding pressure (steam pressure) in increments of 0.01 MPa in an autoclave step, and the minimum molding pressure that enables molding of an in-mold expanded molded product having a “Good” or “Excellent” grade in the following <Fusibility> evaluation was used as the minimum molding pressure.", "The in-mold expanded molded product molded at this minimum molding pressure was evaluated for surface appearance and dimensional accuracy and was measured for density and 50%-strained compressive strength as described below.", "<Fusibility> A 5 mm deep cut was made in the thickness direction in the obtained in-mold expanded molded product with a cutter, and then the in-mold expanded molded product was cleaved by hand.", "The cleaved surface was visually checked, and the percentage of broken expanded particles (not the particles separated at interfaces) was calculated.", "Then, fusibility was judged by the following criteria.", "Excellent: The percentage of broken expanded particles was 80% or more.", "Good: The percentage of broken expanded particles was 60% or more and less than 80%.", "Failed: The percentage of broken expanded particles was less than 60% (degree of fusion was so low that the percentage of the surfaces of expanded particles appearing at the cleaved surface was 40% or more).", "<Surface Appearance (Flat Portion)> A 300 mm×400 mm surface of the obtained in-mold expanded molded product was visually checked, and the surface appearance was judged by the following criteria.", "In regard to inter-particle spaces (spaces between expanded polypropylene resin particles) of surface appearance, the number of inter-particle spaces within a 50 mm×50 mm square at the center of the surface of the in-mold expanded molded product was counted visually and the surface appearance was judged based on this number.", "Excellent (E): The number of inter-particle spaces is 0 to 2, there is no noticeable surface unevenness, and there is no wrinkle or shrinkage and therefore the surface is beautiful.", "Good (G): The number of inter-particle spaces is 3 to 5, there is no noticeable surface unevenness, and there is no shrinkage or wrinkles and therefore the surface is beautiful.", "Failed (F): The number of inter-particle spaces is 6 or more, or surface unevenness, shrinkage, or wrinkles are somewhat noticeable.", "<Surface Appearance (Edge Portion)> In regard to the obtained in-mold expanded molded product, its edge portions (ridge portions) where a 300 mm×400 mm surface meets another surface were visually checked, and the surface appearance was judged by the following criteria.", "In regard to inter-particle spaces (spaces between expanded polypropylene resin particles) of surface appearance, the number of dents at edge portions (ridge portions) along the length and width of the in-mold expanded molded product was counted visually, and the surface appearance was judged on the basis of this number.", "Good (G): The number of dents resulting from expanded polypropylene resin particles is 0 to 5 at each of the edge portions (ridge portions) where faces of the in-mold expanded molded product meet.", "The ridges look good and mold transferability is good.", "In addition, no expanded particles come off even when the edge portions are rubbed with a finger.", "Failed (F): The number of dents resulting from expanded polypropylene resin particles is 6 or more at the edge portions (ridge portions).", "The dents are noticeable and mold transferability is poor.", "<Molding Cycle Time Reduction> The molding cycle time in the method for producing a polypropylene resin in-mold expanded molded product is time from when the molting starts to when the molding ends with the release of a molded product.", "The molding cycle time reduction was determined based on molding cycle time [T0 (seconds)] and molding cycle time [T1 (seconds)] using the following equation.", "Molding cycle time reduction (%)=(T0−T1)/T0×100 The molding cycle time [T0 (seconds)] is molding cycle time in the method for producing a polypropylene resin in-mold expanded molded product from expanded polypropylene resin particles obtained from a polypropylene resin (I) alone as a base resin (without a high density polyethylene resin (II)) by using carbon dioxide as a foaming agent.", "The molding cycle time [T1 (seconds)] is molding cycle time in the method for producing a polypropylene resin in-mold expanded molded product from expanded polypropylene resin particles obtained from a polypropylene resin containing not only the polypropylene resin (I) but also a certain amount of the high density polyethylene resin (II) as a base resin by using carbon dioxide as a foaming agent.", "The molding cycle is defined as below.", "Assume that the point in time at which the expanded polypropylene resin particles start being fed into a mold is the start of molding.", "Heating is performed by feeding steam into the mold, and then the molded product is water-cooled, the mold is opened when the contact pressure obtained using a contact pressure meter attached to the surface of the plank mold reaches 0.05 MPa.", "Assume that the point in time at which the release of the molded product has finished is the end of molding.", "The molding cycle is time from the start of molding to the end of molding.", "Steam heating pressure used in the comparison was the minimum molding pressure.", "A greater molding cycle time reduction means better productivity.", "<Dimensional Accuracy of Molded Product> The length of the obtained in-mold expanded molded product was measured, and the percentage of shrinkage of the in-mold expanded molded product relative to the length (400 mm) of the mold was calculated.", "The dimensional accuracy of the molded product was evaluated based on this percentage of shrinkage.", "Percentage of shrinkage (%)=(400 (mm)−length of molded product (mm))/400 (mm)×100 Excellent (E): Percentage of shrinkage is 2% or less.", "Good (G): Percentage of shrinkage is 2% or greater and less than 2.3%.", "Average (A): Percentage of shrinkage is 2.3% or greater and less than 2.6%.", "Poor (P): Percentage of shrinkage is 2.6% or greater.", "(Evaluation of Quality of in-Mold Expanded Molded Product) The quality of a polypropylene resin in-mold expanded molded product in accordance with one or more embodiments of the present invention includes density of the molded product, 50%-strained compressive strength, and open cell ratio.", "<Density of Molded Product> A test piece having a size of length 50 mm×width 50 mm×thickness 25 mm was cut from around the center of the in-mold expanded molded product.", "Note that a thickness of approximately 12.5 mm was removed from each of the front and back surface layers of the in-mold expanded molded product to obtain the test piece having a thickness of 25 mm.", "The weight W (g) of the test piece was measured, and the length, width, and thickness of the test piece were measured with the use of a caliper, and the volume V (cm3) of the test piece was calculated.", "Then, the density of the molded product is obtained using W/V.", "Note, however, that a conversion was made so that the unit was g/L.", "<50%-Strained Compressive Strength> After the density of the test piece of the molded product was measured, the compressive stress of this test piece when compressed by 50% at a rate of 10 mm/min.", "was measured with the use of a tension and compression testing machine [available from Minebea, TG series] in accordance with NDZ-Z0504.", "(Open Cell Ratio of in-Mold Expanded Molded Product) A test piece having a size of length 25 mm×width 25 mm×thickness 35 mm was cut from around the center of the obtained in-mold expanded molded product, and this test piece was measured for volume Vc2 (cm3) with the use of an air comparison pycnometer (model 1000 available from TOKYO SCIENCE.)", "in accordance with the method defined in PROCEDURE C of ASTM D2856-87.After the measurement of Vc, this in-mold expanded molded product was entirely submerged in ethanol in a graduated cylinder, and the apparent volume Va2 (cm3) of the in-mold expanded molded product was determined from the difference in the liquid level of the graduated cylinder (submersion method).", "The open cell ratio of the in-mold expanded molded product was calculated using the following equation.", "Open cell ratio (%)=(Va2−Vc2)×100/Va2 Example 1 [Preparation of Polypropylene Resin Particles] A polypropylene resin A (as a polypropylene resin (I)) in an amount of 95 parts by weight, a high density polyethylene resin A (as a high density polyethylene resin (II)) in an amount of 5 parts by weight, a polyethylene glycol (as a hydrophilic compound) in an amount of 0.5 parts by weight, and talc (as a foam nucleating agent) in an amount of 0.05 parts by weight were mixed together.", "The obtained mixture was melted and kneaded at a resin temperature of 220° C. and extruded in a strand shape with the use of a twin-screw extruder (TEK45 available from 0.N.", "Machinery Co., Ltd.).", "The strand thus extruded was water-cooled in a water tank having a length of 2 m, and was then cut.", "This resulted in polypropylene resin particles (1.2 mg per particle).", "Flexural modulus was evaluated using these polypropylene resin particles as described earlier, and the result is shown in Table 1 as the flexural modulus of a polypropylene resin (X).", "[Preparation of First-Step Expanded Particles] 100 parts by weight of the polypropylene resin particles obtained, 300 parts by weight of water, 1.5 parts by weight of powdered basic tertiary calcium phosphate (as a dispersing agent), 0.06 parts by weight of n-paraffin sodium sulfonate (as a dispersion auxiliary agent), and 7.5 parts by weight of carbon dioxide (as a foaming agent) were placed in a 10 L pressure-resistant container.", "While the mixture was stirred, the temperature was raised to a foaming temperature shown in Table 1 and the temperature was maintained for 10 min.", "Then, carbon dioxide was additionally injected into the pressure-resistant container and thereby the pressure was adjusted to a foaming pressure shown in Table 1.Then, the pressure was maintained for 30 min.", "Then, a valve at a lower part of the pressure-resistant container was opened while carbon dioxide was injected into the pressure-resistant container and the temperature and pressure inside the pressure-resistant container were maintained, whereby the aqueous dispersion medium was released into air under atmospheric pressure through an orifice plate having an opening diameter of 3.6 mm.", "In this way, expanded polypropylene resin particles (first-step expanded particles) were obtained.", "The obtained first-step expanded particles were measured for high-temperature heat quantity ratio, average cell diameter, open cell ratio, and expansion ratio.", "The results are shown in Table 1.", "[Preparation of in-Mold Expanded Molded Product] The obtained first-step expanded particles were introduced into a pressure-resistant container, and pressurized air was impregnated into the expanded particles and thereby the internal pressure of the expanded particles was adjusted in advance as shown in Table 1.Then, these expanded polypropylene resin particles were filled into a mold having a size of length 300 mm×width 400 mm×thickness 50 mm with a gap of 5 mm in the mold, and the expanded particles were heat molded by compressing by 10% in the thickness direction.", "In this way, a polypropylene resin in-mold expanded molded product was obtained.", "In doing so, after the mold was filled with the expanded polypropylene resin particles and the mold was then completely closed, the air in the mold was first purged by use of steam of 0.1 MPa (gage pressure) (preheating step), and thereafter the particles were heat-molded (autoclave step) with heating steam of the pre-measured minimum molding pressure for 10 seconds, such that an in-mold expanded molded product was obtained.", "The preheating step was performed for 10 seconds, the cross steaming step was performed for 2 seconds, the counter cross steaming step was performed for 2 seconds, and the autoclave step was performed for 10 seconds as described above.", "The results of measurements of molding cycle time reduction, surface appearance, dimensional accuracy of molded product, density of molded product, and 50%-strained compressive strength are shown in Table 1.Example 2 The same operations as described in Example 1 were performed, except that the mixing ratio of the polypropylene resin (I) to the high density polyethylene resin (II) was changed to 90/10 in [Preparation of polypropylene resin particles].", "In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.Example 3 The same operations as described in Example 2 were performed, except that the polypropylene resin (I) was changed to a polypropylene resin B in [Preparation of polypropylene resin particles].", "In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.Example 4 The same operations as described in Example 2 were performed, except that the polypropylene resin (X) in [Preparation of polypropylene resin particles] was a polypropylene resin (X) having a tm of 155° C. and an MFR of 8 g/10 min.", "in which: the polypropylene resin A and a polypropylene resin C were used as the polypropylene resin (I); and the polypropylene resin A, the polypropylene resin C, and the high density polyethylene resin A were mixed at a mixing ratio of 80/10/10.In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.Example 5 The same operations as described in Example 1 were performed, except that the high density polyethylene resin (II) was changed to a high density polyethylene resin B in [Preparation of polypropylene resin particles].", "In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.Example 6 The same operations as described in Example 1 were performed, except that the high density polyethylene resin (II) was changed to a high density polyethylene resin C in [Preparation of polypropylene resin particles].", "In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.Example 7 The same operations as described in Example 1 were performed, except that 5 parts by weight of carbon black was added in [Preparation of polypropylene resin particles].", "In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.Example 8 The same operations as described in Example 1 were performed, except that the high density polyethylene resin (II) was changed to a high density polyethylene resin D in [Preparation of polypropylene resin particles].", "In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.Example 9 The same operations as described in Example 1 were performed, except that the amount of talc as a foam nucleating agent was changed to 0.10 parts by weight in [Preparation of polypropylene resin particles].", "In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.Example 10 The same operations as described in Example 1 were performed, except that the amount of talc as a foam nucleating agent was changed to 0 parts by weight in [Preparation of polypropylene resin particles].", "In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.Example 11 The same operations as described in Example 1 were performed, except that the foam nucleating agent was changed to 0.05 parts by weight of silica in [Preparation of polypropylene resin particles].", "In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.Comparative Example 1 The same operations as described in Example 1 were performed, except that the mixing ratio of the polypropylene resin (I) to the high density polyethylene resin (II) was changed to 100/0 (that is, 100 parts by weight polypropylene resin A was used) in [Preparation of polypropylene resin particles].", "In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.Comparative Example 2 The same operations as described in Example 1 were performed, except that the mixing ratio of the polypropylene resin (I) to the high density polyethylene resin (II) was changed to 80/20 in [Preparation of polypropylene resin particles].", "In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.Comparative Example 3 The same operations as described in Example 1 were performed, except that a linear low-density polyethylene resin was used in place of the high density polyethylene resin (II) in [Preparation of polypropylene resin particles].", "In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.Comparative Example 4 The same operations as described in Example 3 were performed, except that the mixing ratio of the polypropylene resin (I) to the high density polyethylene resin (II) was changed to 100/0 (that is, 100 parts by weight polypropylene resin B was used) in [Preparation of polypropylene resin particles].", "In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.Comparative Example 5 The same operations as described in Comparative Example 1 were performed, except that 5 parts by weight of carbon black was added in [Preparation of polypropylene resin particles].", "In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.Comparative Example 6 The same operations as described in Example 1 were performed, except that the foaming agent was changed from carbon dioxide to isobutane in [Preparation of polypropylene resin particles].", "In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.Comparative Example 7 The same operations as described in Example 1 were performed, except that the foam nucleating agent was changed to 0.05 parts by weight of talc and 0.05 parts by weight of silica in [Preparation of polypropylene resin particles].", "In this way, polypropylene resin particles, expanded polypropylene resin particles, and a polypropylene in-mold expanded molded product were obtained.", "The conditions in which these were produced and the results of evaluations are shown in Table 1.TABLE 1 Examples 1 2 3 4 5 6 7 8 9 Polypro- Polypropylene Polypropylene parts 95 90 80 95 95 95 95 95 pylene resin (I) resin A by resin weight particles Polypropylene parts 90 resin B by weight Polypropylene parts 10 resin C by weight Melting point ° C. 151 151 148 155 151 151 151 151 151 Melt flow rate g/10 min.", "8 8 9 7 8 8 8 8 8 High High density parts 5 10 10 10 5 5 density polyethylene by poly- resin A weight ethylene High density parts 5 resin polyethylene by (II) resin B weight High density parts 5 polyethylene by resin C weight High density parts 5 polyethylene by resin D weight Linear low- parts density by polyethylene weight resin Flexural MPa 1000 1000 1000 1000 1050 1300 1000 850 1000 modulus Additive Talc parts 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.10 by weight Silica parts by weight PEG parts 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 by weight Carbon black parts 5 by weight Polypropylene Melting point tm ° C. 151 151 148 155 151 151 151 151 151 resin Flexural MPa 1280 1250 1300 1350 1300 1330 1250 1200 1280 (X) modulus First- Foaming Amount of parts 7.5 7.5 7.5 7.5 7.5 7.5 7.5 7.5 7.5 step conditions carbon dioxide by expanded weight particles Amount of parts — — — — — — — — — isobutane by weight Foaming ° C. 152 152 149 156 152 152 152 151 152 temperature Foaming MPa 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 pressure (gage pressure) Quality High- % 21 22 21 25 22 23 20 19 22 temperature heat quantity ratio Average cell μm 170 175 175 130 160 180 120 170 140 diameter Open cell ratio % 2.0 3.0 4.0 3.0 2.0 3.0 2.0 2.0 2.5 Expansion ratio times 19 21 21 20 19 22 18 19 21 In-mold Moldability Molding cycle % 7 14 8 17 8 8 7 8 6 expanded time reduction molded Minimum MPa 0.23 0.22 0.21 0.25 0.23 0.23 0.23 0.22 0.23 product molding pressure (gage pressure) Surface Flat — G G G G G G G G G appearance portion Edge — G G G G G G G G G portion Dimensional — E E E E G G E E E accuracy of molded product Quality Density of g/L 25 24 24 25 25 24 27 25 24 molded product 50%-strained MPa 0.23 0.23 0.23 0.24 0.24 0.24 0.23 0.22 0.23 compressive strength Open cell ratio % 8.0 8.0 8.0 8.0 7.0 6.0 8.0 9.0 8.0 Examples Comparative Examples 10 11 1 2 3 4 5 6 7 Polypro- Polypropylene Polypropylene parts 95 95 100 80 95 100 95 95 pylene resin (I) resin A by resin weight particles Polypropylene parts 100 resin B by weight Polypropylene parts resin C by weight Melting point ° C. 151 151 151 151 151 148 151 151 151 Melt flow rate g/10 min.", "8 8 8 8 8 9 8 8 8 High High density parts 5 5 20 5 5 density polyethylene by poly- resin A weight ethylene High density parts resin polyethylene by (II) resin B weight High density parts polyethylene by resin C weight High density parts polyethylene by resin D weight Linear low- parts 5 density by polyethylene weight resin Flexural MPa 1000 1000 — 1000 400 — — 1000 1000 modulus Additive Talc parts 0.00 0.05 0.05 0.05 0.05 0.05 0.05 0.05 by weight Silica parts 0.05 0.05 by weight PEG parts 0.5 0.5 0.5 0.5 0.5 0.5 0.5 by weight Carbon black parts 5 by weight Polypropylene Melting point tm ° C. 151 151 151 150 151 148 151 151 151 resin Flexural MPa 1280 1280 1350 1000 1200 1400 1300 1280 1280 (X) modulus First- Foaming Amount of parts 7.5 7.5 7.5 7.5 7.5 7.5 7.5 — 7.5 step conditions carbon dioxide by expanded weight particles Amount of parts — — — — — — — 152 — isobutane by weight Foaming ° C. 152 152 152 151 152 149 152 133 152 temperature Foaming MPa 3.4 3.4 3.4 3.4 3.4 3.3 3.4 2.5 3.4 pressure (gage pressure) Quality High- % 20 21 21 21 20 21 20 19 20 temperature heat quantity ratio Average cell μm 210 160 85 140 65 90 70 350 150 diameter Open cell ratio % 2.5 2.0 2.0 12.0 2.0 3.5 3.0 4.5 2.5 Expansion ratio times 18 20 19 17 18 20 19 19 19 In-mold Moldability Molding cycle % 7 7 — 40 3 — 0 −20 −4 expanded time reduction molded Minimum MPa 0.23 0.23 0.26 0.22 0.24 0.28 0.26 0.23 0.23 product molding pressure (gage pressure) Surface Flat — G G F F F F F G E appearance portion Edge — G G F F F F F F G portion Dimensional — G E G A G G G G A accuracy of molded product Quality Density of g/L 27 25 26 30 26 25 26 26 25 molded product 50%-strained MPa 0.23 0.23 0.23 0.18 0.23 0.23 0.23 0.21 0.23 compressive strength Open cell ratio % 8.0 8.0 6.0 18.0 8.0 7.0 8.0 9.0 10.0 Example 1 uses a base resin (polypropylene resin (X)) that contains the high density polyethylene resin (II) in an amount of 5 weight %.", "The in-mold expanded molded product obtained in Example 1 has high compressive strength and, in addition, has good surface appearance and a molding cycle reduced by 7% in comparison with Comparative Example 1 in which the high density polyethylene resin (II) is not contained.", "Example 1 was found to bring about the effects of one or more embodiments of the present invention.", "Likewise, Example 2, which used a base resin (polypropylene resin (X)) containing the high density polyethylene resin (II) in an amount of 10 weight %, had a molding cycle time reduction of 14%.", "The molding cycle was even shorter than Example 1.Furthermore, the obtained in-mold expanded molded product was found to have good surface appearance and high compressive strength.", "Similar effects were obtained also in Examples 3 and 4, in which the polypropylene resin (I) having a different composition was used.", "Similar effects were obtained also in Examples 5, 6, and 8, in which a different kind of high density polyethylene (II) was used and the amount of the high density polyethylene (II) added was 5 parts by weight %.", "Also in Example 7, in which carbon black was contained in 5 parts by weight %, surface appearance was found to be good.", "In Examples 9 and 10, in which the amount of talc as a foam nucleating agent was changed to 0.10 parts by weight or 0 parts by weight, similar effects were obtained.", "In Example 11, in which silica as a foam nucleating agent was contained in an amount of 0.05 parts by weight, similar effects were obtained.", "Comparative Example 2 used a base resin (polypropylene resin (X)) containing an excess amount (20 weight %) of the high density polyethylene resin (II).", "This resulted in an in-mold expanded molded product having poor surface appearance and reduced compressive strength.", "Comparative Example 3 used a base resin containing a linear low-density polyethylene instead of the high density polyethylene (II).", "This resulted in fine average cell diameter and very poor surface appearance.", "Comparative Examples 4 and 5 contained no high density polyethylene.", "This resulted in unimproved surface appearance.", "Comparative Example 6, which used isobutane as a foaming agent, resulted in large average cell diameter.", "As a result, in the method for producing an in-mold expanded molded product, the molded product locally had poor fusibility, edge portions were partially chipped, and surface appearance deteriorated.", "Comparative Example 7 contained 0.05 parts by weight of talc and 0.05 parts by weight of silica as foam nucleating agents.", "This resulted in good surface appearance of the resulted in-mold expanded molded product.", "However, poor results were obtained in molding cycle and dimensional accuracy of the molded product.", "Although the disclosure has been described with respect to only a limited number of embodiments, those skilled in the art, having benefit of this disclosure, will appreciate that various other embodiments may be devised without departing from the scope of the present invention.", "Accordingly, the scope of the present invention should be limited only by the attached claims." ] ]
Patent_15875911
[ [ "BUFFER STATION WITH SINGLE EXIT-FLOW DIRECTION", "A buffer for use in semiconductor processing tools is disclosed.", "The buffer may be used to temporarily store wafers after processing operations are performed on those wafers.", "The buffer may include two side walls and a back wall interposed between the side walls.", "The side walls and the back wall may generally define an area within which the wafers may be stored in a stacked arrangement.", "Wafer support fins extending from the side walls and the back wall may extend into a wafer support region that overlaps with the edges of the wafers.", "Purge gas may be introduced in between each pair of wafers via purge gas ports located in one of the walls." ], [ "1.A buffer for storing multiple wafers in a semiconductor manufacturing tool, the buffer comprising: two opposing side walls; a back wall; at least one heater platen, the at least one heater platen configured to heat one or more walls selected from the group consisting of: a first side wall of the opposing side walls, a second side wall of the opposing side walls, and the back wall; a plurality of support fins; and a plurality of purge gas ports, wherein: the two opposing side walls and the back wall define part of an interior buffer volume; at least one purge gas port is located between each adjacent pair of support fins; the purge gas ports are located in one or more walls selected from the group consisting of: the first side wall, the second side wall, and the back wall; the interior buffer volume has an opening opposite the back wall; the opposing side walls are between the opening and the back wall; and each support fin: a) extends from the back wall, along both side walls, and to the opening, b) is substantially flat and horizontal when the buffer is in use, c) has a wafer support region that is smaller in diameter than the wafers with which the buffer is designed to be used, d) extends from the side walls and the back wall in a substantially unbroken manner up to at least the wafer support region, and e) has a cutout region that extends from the opening past the center of the wafer support region and that is wide enough in a direction transverse to the opening to allow an end effector of a wafer handling robot to place a wafer on the support fin.", "2.The buffer of claim 1, further comprising an inert gas source configured to provide a gas selected from the group consisting of: nitrogen gas and other inert gases.", "3.The buffer of claim 1, wherein: the opposing side walls, the back wall, the ceiling, and the floor seal the interior buffer volume off from the surrounding environment; and the opening is the only substantial flow path out of the interior buffer volume into the surrounding environment for gas flowed into the interior buffer volume through the purge gas ports 4.The buffer of claim 1, wherein the at least one heater platen includes a first heater platen configured to heat a first side wall of the side walls and a second heater platen configured to heat a second side wall of the side walls.", "5.The buffer of claim 4, wherein the first heater platen is in thermally conductive contact with the first side wall and the second heater platen is in thermally conductive contact with the second side wall.", "6.The buffer of claim 1, wherein the at least one heater platen includes a first heater platen configured to heat the back wall.", "7.The buffer of claim 6, wherein the first heater platen is in thermally conductive contact with the back wall.", "8.The buffer of claim 1, wherein there is a single purge gas port between each pair of adjacent support fins and each purge gas port of the plurality of purge gas ports is a long, thin slot running in a direction parallel to the adjacent support fins.", "9.The buffer of claim 1, wherein there is a plurality of purge gas ports between each pair of adjacent support fins.", "10.The buffer of claim 1, wherein each plurality of purge gas ports between each pair of adjacent support fins is arranged in a linear arrangement.", "11.The buffer of claim 1, wherein the plurality of purge gas ports includes purge gas ports located in the back wall.", "12.The buffer of claim 1, wherein the plurality of purge gas ports includes purge gas ports located in at least one side wall.", "13.The buffer of claim 1, wherein the plurality of purge gas ports includes purge gas ports located in the side walls and the back wall.", "14.The buffer of claim 1, further comprising: one or more plenum covers; and one or more plenum cavities, wherein: each plenum cavity is defined, at least in part, by a surface of one of the one or more plenum covers and a surface of one of the walls selected from the group consisting of the side walls and the back wall facing away from the interior buffer volume, and multiple purge gas ports of the plurality of purge gas ports fluidically connect with each plenum cavity.", "15.The buffer of claim 1, further comprising: an exhaust port; and a clean air inlet, wherein the clean air inlet is configured to flow gas across the opening and into the exhaust port.", "16.An equipment front-end module (EFEM) for a semiconductor processing tool, the EFEM comprising: an EFEM housing; one or more loadlocks configured to allow wafers to be transferred from the EFEM to a transfer chamber or process chamber of the semiconductor processing tool; one or more mechanical interfaces for supporting front-opening unified pods (FOUPs); a wafer transfer robot configured to transfer wafers between various stations within the EFEM; and one or more of the buffers of claim 1.17.The buffer of claim 1, wherein each support fin overlaps over X% of the outer perimeter of one of the wafers when the wafer is in the wafer support region and supported by the support fin, wherein X is a value selected from the group consisting of: 50 and 75.18.The buffer of claim 1, wherein the wafer support region lies within an annular area with an outer diameter larger than the wafer diameter and an inner diameter within 1″ of the wafer diameter.", "19.The buffer of claim 1, wherein: the wafer support region of each support fin is provided by a recessed area in a surface of the support fin that faces upwards when the buffer is in use; and the recessed area of each support fin is recessed to a depth that causes a wafer supported by the support region to be substantially flush with the surface of the support fin that faces upwards when the buffer is in use.", "20.The buffer of claim 1, wherein: the cutout region has a circular portion of a larger diameter than the wafer, each support fin has a plurality of pegs extending from a surface of the support fin facing the center of the circular portion, and the wafer support region is an annular area that includes the pegs within its boundaries.", "21.The buffer of claim 1, wherein the plurality of support fins is selected from the group consisting of: 24 support fins, 25 support fins, 29 support fins, and 30 support fins." ], [ "<SOH> BACKGROUND <EOH>Semiconductor processing operations are often performed in a semiconductor processing tool, which may feature several semiconductor processing chambers or reactors that are connected to a transfer chamber of some sort; the transfer chamber and the semiconductor processing chambers are typically connected together in a hermetically-sealed manner and kept under vacuum conditions.", "Wafers are typically provided to, and removed from, the transfer chamber via loadlocks.", "The loadlocks are typically connected to an Equipment Front End Module (EFEM), which is usually a structure with a wafer handling robot inside that is configured to move wafers between the load locks and a number of other structures within, or attached to, the EFEM.", "The internal environment of the EFEM is typically referred to as a “mini-environment”; filtered, dry air is typically constantly flowed through the mini-environment (it is not practical to keep the EFEM at a vacuum, which is why loadlocks are used as a barometric interface between the EFEM and the transfer chamber).", "Wafers are typically supplied to the EFEM using cassettes of vertically-stacked wafers (e.g., 25 or 30 wafers) called Front-Opening Unified Pods (FOUPs); the robot in the EFEM may pick a wafer from a FOUP and transfer it to the loadlock, or may transfer processed wafers into a FOUP.", "Industry standard processes typically mandate that a FOUP contain only unprocessed (and thus clean) wafers or contain only processed (and potentially dirty) wafers—mixing unprocessed and processed wafers in a single FOUP is considered undesirable and is against industry standard practices.", "Moreover, wafers are often quite hot after they exit processing, and it may be undesirable to put hot wafers into the FOUPs until they are cooled down.", "To that end, an EFEM will often include a buffer or buffer station that may be used to temporarily store in-process wafers before they are transferred to the processed wafer FOUP.", "Buffers typically hold a large number, e.g., 25 or 30, wafers in a vertically-stacked arrangement.", "Since the wafers that are stored in a buffer have usually undergone recent semiconductor processing operations, they often have chemical residuals from the processing operations on their exposed surfaces.", "Moisture and oxygen in the mini-environment of the EFEM may react with such chemical residues, causing damage to the processed wafers and can also damage the components of the buffer or EFEM near the wafers.", "One technique for mitigating such chemical reactions is to use a buffer such as is described in KR 1020130059574, published Jul.", "6, 2013.Such a buffer includes two opposing, vertical stacks of plates that are at least a wafer diameter apart.", "Small, short ledges extend from alternating instances of such plates and provide a small support area on which each wafer may rest.", "These ledges extend around only a short distance of the wafer perimeter on opposing sides of the wafer, e.g., around about ⅛ th of the wafer circumference on each opposing side.", "A series of vertical gas delivery tubes extends upwards through each plate instance, and nozzles in each tube are used to direct purge gas out of slots in alternating instances of the plates and towards the mid-plane of the wafers.", "The purge gas in this case flows towards the middle of the wafers as well as towards the front and the back of the wafer." ], [ "<SOH> SUMMARY <EOH>The systems, methods and devices of the disclosure each have several innovative aspects, no single one of which is solely responsible for the desirable attributes disclosed herein.", "One innovative aspect of the subject matter described in this disclosure can be implemented in a variety of ways.", "In some implementations, a buffer for storing multiple wafers in a semiconductor manufacturing tool is provided.", "The buffer may include two opposing side walls, a back wall, and a plurality of support fins.", "The two opposing side walls and the back wall may define part of an interior buffer volume which may have an opening opposite the back wall; the opposing side walls may be between the opening and the back wall.", "Each support fin may extend from the back wall, along both side walls, and to the opening.", "Each support fin may also be substantially flat and horizontal when the buffer is in use and have a wafer support region that is smaller in diameter than the wafers with which the buffer is designed to be used.", "The support fins may also extend from the side walls and the back wall in a substantially unbroken manner up to at least the wafer support region, and may have a cutout region that extends from the opening past the center of the wafer support region and that is wide enough in a direction transverse to the opening to allow an end effector of a wafer handling robot to place a wafer on the support fin.", "In some implementations, each support fin may be offset from the adjacent support fin or support fins and the support fins form a vertical linear array when the buffer is in use.", "In some implementations, the buffer may also include a ceiling and a floor.", "The interior buffer volume may be further defined by the ceiling and the floor and the back wall and the two sidewalls may be between the ceiling and the floor.", "In some such implementations, the opposing side walls, the back wall, the ceiling, and the floor may seal the interior buffer volume off from the surrounding environment, and the opening may be the only substantial flow path out of the interior buffer volume.", "In some implementations, each support fin may overlap over 50% of the outer perimeter of one of the wafers when the wafer is in the wafer support region and supported by the support fin.", "In some further implementations, each support fin may overlap over 75% of the outer perimeter of one of the wafers when the wafer is in the wafer support region and supported by the support fin.", "In some implementations, the wafer support region may lie within an annular area with an outer diameter larger than the wafer diameter and an inner diameter within 1″ of the wafer diameter.", "In some implementations, the wafer support region of each support fin may be provided by a recessed area in a surface of the support fin that faces upwards when the buffer is in use and the recessed area of each support fin may be recessed to a depth that causes a wafer supported by the support region to be substantially flush with the surface of the support fin that faces upwards when the buffer is in use.", "In some implementations, the cutout region may have a circular portion of a larger diameter than the wafer, each support fin may have a plurality of pegs extending from a surface of the support fin facing the center of the circular portion, and the wafer support region may have an annular area that includes the pegs within its boundaries.", "In some implementations, the number of support fins may 24 support fins, 25 support fins, 29 support fins, or 30 support fins, or really any number of support fins that is desired.", "In some implementations, the buffer may include at least one heater platen that may be in thermally-conductive contact with at least one of the side walls or the back wall.", "In some implementations, the buffer may include a plurality of purge gas ports, and there may be at least one purge gas port between each pair of adjacent support fins.", "In some such implementations, there may be a single purge gas port between each pair of adjacent support fins and each purge gas port may have the shape of a long, thin slot running in a direction parallel to the adjacent support fins.", "In some other such implementations, there may be a plurality of purge gas ports between each pair of adjacent support fins.", "In some such implementations, each such plurality of purge gas ports between each pair of adjacent support fins may include a linear array of regularly-spaced purge gas ports.", "In some implementations, the plurality of purge gas ports may include purge gas ports located in the back wall.", "In some other or additional implementations, the plurality of purge gas ports may include purge gas ports located in at least one side wall.", "In some implementations, the buffer may also include a plenum cover and a plenum cavity.", "The plenum cavity may be defined, at least in part, by the plenum cover and a surface of the back wall opposite the interior buffer volume and the plenum cavity may be in fluidic communication with the plurality of purge gas ports.", "In some implementations, the buffer may also include an exhaust port and a clean air inlet.", "The clean air inlet may be configured to flow gas across the opening and into the exhaust port.", "In some implementations, an equipment front-end module (EFEM) for a semiconductor processing tool may be provided.", "The EFEM may include an EFEM housing, one or more loadlocks configured to allow wafers to be transferred from the EFEM to a transfer chamber or process chamber of the semiconductor processing tool, one or more mechanical interfaces for supporting front-opening unified pods (FOUPs), a wafer transfer robot configured to transfer wafers between various stations within the EFEM, and one or more of the buffers described above.", "Details of one or more implementations of the subject matter described in this specification are set forth in the accompanying drawings and the description below.", "Other features, aspects, and advantages will become apparent from the description, the drawings, and the claims." ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application is a continuation of and claims priority to U.S. application Ser.", "No.", "14/523,122, filed Oct. 24, 2014, titled “BUFFER STATION WITH SIGNAL EXIT-FLOW DIRECTION” and which issued on Jan. 30, 2018, as U.S. Pat.", "No.", "9,881,826, which is incorporated herein by reference in its entirety and for all purposes.", "BACKGROUND Semiconductor processing operations are often performed in a semiconductor processing tool, which may feature several semiconductor processing chambers or reactors that are connected to a transfer chamber of some sort; the transfer chamber and the semiconductor processing chambers are typically connected together in a hermetically-sealed manner and kept under vacuum conditions.", "Wafers are typically provided to, and removed from, the transfer chamber via loadlocks.", "The loadlocks are typically connected to an Equipment Front End Module (EFEM), which is usually a structure with a wafer handling robot inside that is configured to move wafers between the load locks and a number of other structures within, or attached to, the EFEM.", "The internal environment of the EFEM is typically referred to as a “mini-environment”; filtered, dry air is typically constantly flowed through the mini-environment (it is not practical to keep the EFEM at a vacuum, which is why loadlocks are used as a barometric interface between the EFEM and the transfer chamber).", "Wafers are typically supplied to the EFEM using cassettes of vertically-stacked wafers (e.g., 25 or 30 wafers) called Front-Opening Unified Pods (FOUPs); the robot in the EFEM may pick a wafer from a FOUP and transfer it to the loadlock, or may transfer processed wafers into a FOUP.", "Industry standard processes typically mandate that a FOUP contain only unprocessed (and thus clean) wafers or contain only processed (and potentially dirty) wafers—mixing unprocessed and processed wafers in a single FOUP is considered undesirable and is against industry standard practices.", "Moreover, wafers are often quite hot after they exit processing, and it may be undesirable to put hot wafers into the FOUPs until they are cooled down.", "To that end, an EFEM will often include a buffer or buffer station that may be used to temporarily store in-process wafers before they are transferred to the processed wafer FOUP.", "Buffers typically hold a large number, e.g., 25 or 30, wafers in a vertically-stacked arrangement.", "Since the wafers that are stored in a buffer have usually undergone recent semiconductor processing operations, they often have chemical residuals from the processing operations on their exposed surfaces.", "Moisture and oxygen in the mini-environment of the EFEM may react with such chemical residues, causing damage to the processed wafers and can also damage the components of the buffer or EFEM near the wafers.", "One technique for mitigating such chemical reactions is to use a buffer such as is described in KR 1020130059574, published Jul.", "6, 2013.Such a buffer includes two opposing, vertical stacks of plates that are at least a wafer diameter apart.", "Small, short ledges extend from alternating instances of such plates and provide a small support area on which each wafer may rest.", "These ledges extend around only a short distance of the wafer perimeter on opposing sides of the wafer, e.g., around about ⅛th of the wafer circumference on each opposing side.", "A series of vertical gas delivery tubes extends upwards through each plate instance, and nozzles in each tube are used to direct purge gas out of slots in alternating instances of the plates and towards the mid-plane of the wafers.", "The purge gas in this case flows towards the middle of the wafers as well as towards the front and the back of the wafer.", "SUMMARY The systems, methods and devices of the disclosure each have several innovative aspects, no single one of which is solely responsible for the desirable attributes disclosed herein.", "One innovative aspect of the subject matter described in this disclosure can be implemented in a variety of ways.", "In some implementations, a buffer for storing multiple wafers in a semiconductor manufacturing tool is provided.", "The buffer may include two opposing side walls, a back wall, and a plurality of support fins.", "The two opposing side walls and the back wall may define part of an interior buffer volume which may have an opening opposite the back wall; the opposing side walls may be between the opening and the back wall.", "Each support fin may extend from the back wall, along both side walls, and to the opening.", "Each support fin may also be substantially flat and horizontal when the buffer is in use and have a wafer support region that is smaller in diameter than the wafers with which the buffer is designed to be used.", "The support fins may also extend from the side walls and the back wall in a substantially unbroken manner up to at least the wafer support region, and may have a cutout region that extends from the opening past the center of the wafer support region and that is wide enough in a direction transverse to the opening to allow an end effector of a wafer handling robot to place a wafer on the support fin.", "In some implementations, each support fin may be offset from the adjacent support fin or support fins and the support fins form a vertical linear array when the buffer is in use.", "In some implementations, the buffer may also include a ceiling and a floor.", "The interior buffer volume may be further defined by the ceiling and the floor and the back wall and the two sidewalls may be between the ceiling and the floor.", "In some such implementations, the opposing side walls, the back wall, the ceiling, and the floor may seal the interior buffer volume off from the surrounding environment, and the opening may be the only substantial flow path out of the interior buffer volume.", "In some implementations, each support fin may overlap over 50% of the outer perimeter of one of the wafers when the wafer is in the wafer support region and supported by the support fin.", "In some further implementations, each support fin may overlap over 75% of the outer perimeter of one of the wafers when the wafer is in the wafer support region and supported by the support fin.", "In some implementations, the wafer support region may lie within an annular area with an outer diameter larger than the wafer diameter and an inner diameter within 1″ of the wafer diameter.", "In some implementations, the wafer support region of each support fin may be provided by a recessed area in a surface of the support fin that faces upwards when the buffer is in use and the recessed area of each support fin may be recessed to a depth that causes a wafer supported by the support region to be substantially flush with the surface of the support fin that faces upwards when the buffer is in use.", "In some implementations, the cutout region may have a circular portion of a larger diameter than the wafer, each support fin may have a plurality of pegs extending from a surface of the support fin facing the center of the circular portion, and the wafer support region may have an annular area that includes the pegs within its boundaries.", "In some implementations, the number of support fins may 24 support fins, 25 support fins, 29 support fins, or 30 support fins, or really any number of support fins that is desired.", "In some implementations, the buffer may include at least one heater platen that may be in thermally-conductive contact with at least one of the side walls or the back wall.", "In some implementations, the buffer may include a plurality of purge gas ports, and there may be at least one purge gas port between each pair of adjacent support fins.", "In some such implementations, there may be a single purge gas port between each pair of adjacent support fins and each purge gas port may have the shape of a long, thin slot running in a direction parallel to the adjacent support fins.", "In some other such implementations, there may be a plurality of purge gas ports between each pair of adjacent support fins.", "In some such implementations, each such plurality of purge gas ports between each pair of adjacent support fins may include a linear array of regularly-spaced purge gas ports.", "In some implementations, the plurality of purge gas ports may include purge gas ports located in the back wall.", "In some other or additional implementations, the plurality of purge gas ports may include purge gas ports located in at least one side wall.", "In some implementations, the buffer may also include a plenum cover and a plenum cavity.", "The plenum cavity may be defined, at least in part, by the plenum cover and a surface of the back wall opposite the interior buffer volume and the plenum cavity may be in fluidic communication with the plurality of purge gas ports.", "In some implementations, the buffer may also include an exhaust port and a clean air inlet.", "The clean air inlet may be configured to flow gas across the opening and into the exhaust port.", "In some implementations, an equipment front-end module (EFEM) for a semiconductor processing tool may be provided.", "The EFEM may include an EFEM housing, one or more loadlocks configured to allow wafers to be transferred from the EFEM to a transfer chamber or process chamber of the semiconductor processing tool, one or more mechanical interfaces for supporting front-opening unified pods (FOUPs), a wafer transfer robot configured to transfer wafers between various stations within the EFEM, and one or more of the buffers described above.", "Details of one or more implementations of the subject matter described in this specification are set forth in the accompanying drawings and the description below.", "Other features, aspects, and advantages will become apparent from the description, the drawings, and the claims.", "DRAWINGS FIG.", "1 depicts an isometric view of an example of a buffer with a single exit flow direction.", "FIG.", "2 depicts an isometric exploded view of the buffer of FIG.", "1.FIG.", "3 depicts a side section view of the buffer of FIG.", "1.FIG.", "4 depicts a detail view of a portion of FIG.", "3.FIG.", "5 depicts an isometric section view of the buffer of FIG.", "1.FIG.", "6 depicts a plan section view of the buffer of FIG.", "1.FIG.", "7 depicts an isometric plan section view of the buffer of FIG.", "1.FIG.", "8 depicts a plan section view of the buffer of FIG.", "1 without any wafers present.", "FIG.", "9 depicts an isometric plan section view of the buffer of FIG.", "1 without any wafers present.", "FIG.", "10 depicts an isometric view of a buffer installed into a housing that is configured to direct clean air across the front of the buffer.", "FIG.", "11 depicts an isometric section view of the buffer and housing of FIG.", "10.FIG.", "12 depicts an isometric exploded section view of the buffer and housing of FIG.", "10.FIG.", "13 depicts a plan view of an EFEM with two buffers installed.", "FIG.", "14 depicts a top section view of an example buffer similar to the buffer shown in FIG.", "1.FIG.", "15 depicts a top section view of another example buffer.", "FIG.", "16 depicts a top section view of yet another example buffer.", "FIG.", "17 depicts a top sectional view of a buffer with a hexagonal cross-section.", "FIG.", "18 depicts a top sectional view of a buffer with a cylindrical back wall.", "FIG.", "19 depicts an exploded isometric view of another example of an implementation of a buffer.", "FIG.", "19′ depicts a detail view of a portion of FIG.", "19.FIG.", "20 depicts an isometric section view of the example buffer of FIG.", "19.FIG.", "21 depicts another isometric section view of the example buffer of FIG.", "19.FIG.", "22 depicts a top section view of the example buffer of FIG.", "19.FIG.", "23 depicts a front view of a buffer with a side-mounted exhaust and side-mounted filtered air inlet.", "FIG.", "24 depicts a front view of a buffer with bottom-mounted exhaust and a top-mounted filtered air inlet.", "FIG.", "25 depicts a front view of a buffer with top-mounted filtered air inlet and side- and bottom-mounted exhausts.", "FIGS.", "1 through 22 are drawn to-scale within each Figure, with the exception of the purge gas ports in some of the figures, which have been increased in diameter to allow for easier visibility.", "DETAILED DESCRIPTION Examples of various embodiments are illustrated in the accompanying drawings and described further below.", "It will be understood that the discussion herein is not intended to limit the claims to the specific embodiments described.", "On the contrary, it is intended to cover alternatives, modifications, and equivalents as may be included within the spirit and scope of the invention as defined by the appended claims.", "In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention.", "The present invention may be practiced without some or all of these specific details.", "In other instances, well-known process operations have not been described in detail in order not to unnecessarily obscure the present invention.", "The present inventors have realized that existing buffers may be considerably improved in a number of ways.", "For example, the present inventors determined that a buffer that is effectively closed off from the ambient environment except for the side of the buffer through which wafers are inserted into (and removed from) the buffer may provide a much higher purity purge gas environment as compared with traditional buffers.", "In traditional buffers, the front and the back surface of the buffer are typically open to the ambient environment and purge gas is directed into the gaps between the wafers stacked within the buffer from ports located on either side of the wafer.", "The purge gas then flows towards the middle, front, and back of the wafers and then down into some form of exhaust system, where it is scrubbed and disposed of.", "The present inventors determined that due to the fact traditional buffers are largely open structures, e.g., with no back wall, wafers resting in such buffers are inevitably exposed to air from the minienvironment—even if purge gas is injected between the wafers.", "This is because there is always a pressure differential between the front and back sides of such a buffer, and this pressure differential causes air from the EFEM to be drawn through the wafer stack (perhaps at a slow overall rate, but drawn through nonetheless).", "The present inventors determined that enclosing the buffer on at least three sides eliminates the cross-flow gas contamination issue discussed above, as there is only one significant entry/exit from the buffer from a bulk gas flow perspective.", "The present inventors further determined that supporting the wafers in a manner that provides a substantially unbroken surface extending from the wafers' edges towards the side walls and the back wall of the buffer (assuming that the opening through which the wafers are inserted into or removed from the buffer is in the “front” of the buffer) may provide enhanced purge gas effectiveness by limiting inter-wafer purge gas flow.", "Such support may be provided by support fins that extend inwards towards the center of the buffer from the side walls and the back wall.", "The support fins may have a cutout region in the middle that allows a wafer handling robot to insert an end effector into the buffer, move the end effector in a vertical, upwards direction to lift a wafer up from below, and then retract the end effector and the wafer from the buffer.", "The cutout region may thus extend from the opening in the front of the buffer to a point between the nominal center of mass of the wafers and the back wall.", "The support fins and wafers, when the wafers are resting on the support fins, each form an effectively continuous shelf that extends from the back wall, along the side walls, and to the front of the buffer.", "Without the wafers, there would be a large hole in the middle of each support fin where the cutout region is; the wafers, when present, act to cover this hole up.", "The support fin/wafer combination acts to limit vertical migration of gas within the buffer.", "The present inventors also determined that purge gas flowed into the space above each support fin from linear arrays of purge gas ports in one or more walls of the buffer may flow across the support fin and the wafer supported by the support fin (if present).", "The purge gas may thus flow in a primarily horizontal direction (with respect to the Earth frame of reference) until it exits the buffer through the opening through which the wafers are introduced into the buffer.", "While the purge gas ports may be located in either or both of the side walls of the buffer, the present inventors determined that locating purge gas ports in the back wall of the buffer appeared to offer advantageous performance.", "Purge gas flowed from the back wall may generally flow directly across each wafer towards the opening, i.e., in a single, overall direction, with little risk of dead zones in which purge gas and volatiles from the wafers may collect and loiter.", "Generally speaking, the opening (or, more specifically, the boundary formed by the edges of the wafers and support fins closest to the opening) may be the only substantial flow path exit out of the interior buffer volume (assuming that, in cases where the floor of the buffer is open, a wafer is in the bottom-most position in the buffer) for the purge gas that is introduced into the interior buffer volume.", "For example, while there may be some incidental leakage of purge gas out of seams or other small gaps/holes/etc.", "that may be present in the buffer (e.g., in order to accommodate various features needed to assemble the buffer), such incidental gas flow is completely overshadowed by the gas flow out of the opening, e.g., on the order of three or more magnitudes less than the magnitude of gas flow through the opening.", "This causes the purge gas that is introduced into the gap above each wafer to flow across the wafer up to the edge of that wafer closest to the front opening of the buffer and then be drawn into an exhaust without causing air from the EFEM to be drawn into that same space.", "The following discussion is directed at an example implementation of a buffer designed according to these principles.", "It is to be understood that other implementations may be designed differently while still practicing some or all of the concepts discussed herein, and the present disclosure is not limited to just the implementation shown.", "FIG.", "1 depicts an isometric view of an example of a buffer with a single exit flow direction.", "FIG.", "2 depicts an isometric exploded view of the buffer of FIG.", "1.A buffer 100 is shown in FIGS.", "1 and 2.The buffer 100 has a rectangular prismatic shape, although other shapes are possible as well, including a buffer with a semicircular back wall, or a buffer with side walls that taper together between the back wall and the wafer centers (thus forming more of a hexagonal shape in the plan view).", "The buffer 100 has a lid or ceiling 106, which in this implementation, includes handles 136 that protrude out from the ceiling 106 and allow for easy grasping and handling of the buffer 100.A pair of heating platens 126 may be in thermally-conductive contact with side walls 102 of the buffer 100 (such heating platens may also or alternatively located in other positions, e.g., on the ceiling/lid, the floor, the back wall, etc.).", "The heating platens 126 may be used to heat the walls of the buffer and to help drive out any moisture that may manage to stray inside of the buffer.", "Some implementations may forego the inclusion of the heating platens 126 if heating is not needed.", "The implementation of the buffer 100 that is shown in FIG.", "1 is configured to flow gas from purge gas ports located in a back wall 104 of the buffer 100 into an interior buffer volume 112 and towards an opening 114 in the front of the buffer 100.The purge gas, in this implementation, may be distributed to the purge gas ports by way of a plenum cavity 130 that is formed between a plenum cover 128 and the back wall 104.If purge gas ports are additionally or alternatively located in the side wall(s) 102 of the buffer 100, a similar plenum structure may be used on those side walls.", "Such purge gas may, for example, be nitrogen or some other inert gas.", "As can be seen in FIG.", "2, a plurality of wafers 118 may be stored within the buffer 100.In this particular implementation, 25 wafers 118 may be stored in the buffer 100, although other implementations may store other numbers of wafers 118, e.g., 30 wafers, 35 wafers, etc.", "The wafers shown here are 300 mm wafers, although the concepts described herein may be adapted to provide buffers for 450 mm wafers or any other size of wafer.", "Also visible in FIG.", "1 are a plurality of support fins 110.Each support fin 102 has a wafer support region that is, in this implementation, C-shaped, with the inside radius of the C being smaller than one half the wafer nominal diameter, and the outside radius of the C being larger than one half the wafer nominal diameter.", "The wafer support region may be generally flat or planar, and may typically include three or more wafer support features 140 located at spaced-apart locations in the wafer support region.", "The wafer support features 140 may serve to elevate the wafer off of the wafer support region such that each wafer 118 has minimal contact with the support fin 110 that supports it.", "This helps reduce particulate generation/contamination.", "The wafer support region may, for example, lie within an annular region with an outer diameter larger than the wafer diameter and an inner diameter that is within 1″ of the wafer diameter, although other implementations may have different sized wafer support regions.", "In the implementation shown, there are 24 support fins 110 shown.", "The 25th wafer 118 (the bottom-most wafer 118) is supported by a wafer support region that is part of a floor 108.This last wafer support region could just as easily be provided using a 25th support fin 110, however.", "The region within the inside radius of the C may be thought of as a cutout region with a cutout region throat 144.The cutout region throat 144 may be sized so as to be wide enough to allow an end effector of a wafer handling robot with which the buffer is to be used to be inserted into the cutout region via the cutout region throat 144.In some implementations, the cutout region and the cutout region throat 144 may be the same width, i.e., having the form of a large slot that travels towards the back wall 104 from the opening 114.The various components shown may be assembled together using any appropriate fastening techniques, e.g., threaded fasteners, clips, etc.", "Such assembly features are not necessarily shown in the Figures to avoid undue visual clutter.", "FIG.", "3 depicts a side section view of the buffer of FIG.", "1.FIG.", "4 depicts a detail view of a portion of FIG.", "3.Arrows showing notional gas flow paths have been added to this view to help illustrate the flow of purge gas in the buffer 100.Purge gas may flow into the plenum cavity 130 that is formed between the plenum cover 128 and the back wall 104 from purge gas inlets 142.In this implementation, there are two purge gas inlets 142 located in a side portion of the plenum cover 128, although more or fewer such purge gas inlets 142 may be used and the location or locations of such purge gas inlets may be varied.", "The purge gas may flow into the plenum cavity 130 and then flow through the back wall 104 through a number of linear arrays of purge gas ports 124.Each linear array of purge gas ports 124 may flow gas into the space above one of the support fins 110 (and wafer 118, if present).", "Generally, the wafers 118 may be supported by sequentially adjacent support fins 110, i.e., without empty support fins 110 between the wafers, so that the bottom of each wafer 118 forms a “ceiling” for the space between the wafer 118 and the support fin 110 directly below that wafer 118.This “ceiling” helps constrain the flow of purge gas in a generally linear direction towards the opening 114.The “ceiling” for the topmost wafer 118 in the buffer 100 may be provided by the actual ceiling or lid 106.In the support fins 110 shown, the wafer support region 116 is formed by a recessed area 122 that allows the wafer 118 to sit below the nominal upper surface of the support fin 110 instead of sitting proud of, or flush with, the upper surface.", "As can be seen, there is both a radial gap and an axial gap between the wafer 118 and the support fin 110.The radial gap is to accommodate radial uncertainty in wafer placement by the robot arm that handles the wafers.", "The axial gap is to accommodate the wafer support features 140 and to prevent the wafer 118 from actually coming into contact with the wafer support region.", "Purge gas may, of course, flow through these small gaps and migrate between different inter-wafer spaces, but the conductance of such gaps is completely overshadowed by the conductance of the large passage formed between the opening 114 and the back wall 104 between each pair of adjacent support fins 110.These gaps may typically be on the order of a millimeter or two or less.", "More specifically, the radial gap may be kept as small as the radial positioning tolerance of the robot arm reasonably permits.", "The axial gap may, in some implementations, be reduced to the minimum gap that still provides sufficient clearance to prevent the possibility of as small as is necessary to keep the wafer 118 from contacting the wafer support region (except at the wafer support features 140).", "Some implementations of the buffer may provide a wafer support region without wafer support features, allowing for large-area contact between the wafer and the wafer support region (this may provide for less gas migration through this interface due to the smaller gap size, or lack thereof, but at the expense of potentially greater contaminate production due to the increased contact area).", "The buffers described herein may also be implemented without recessed areas (or with recessed areas of shallower depth) such that the wafer 118 stands at least slightly proud of the upper surface of the supporting support fin 110.Such implementations, however, may see an increase in the amount of purge gas migration between inter-wafer spaces since the flow path between the wafers 118 and the support fins 110 is less tortuous as compared with support fins 110 with recessed areas 122.In yet other implementations, the recess may be sized such that the wafer is substantially flush with the support fin top surface.", "As discussed above, while the implementation shown in the accompanying Figures is designed to prevent or mitigate purge gas flow between the stacked wafers 118, there may still be some such purge gas migration, e.g., via small gaps between the wafers 118 and the wafer support regions 116.While the example buffer 100 shown in the Figures avoids including features other than the above-mentioned gaps that may allow for inter-wafer gas flow, some buffer implementations may include additional features that allow for inter-wafer gas migration.", "While such features are generally undesirable from the perspective of this disclosure, there may be other considerations that warrant their inclusion, e.g., visual or optical inspection considerations, assembly considerations, etc.", "To that end, while it is generally preferable that each support fin 110 be without perforations or gaps between the wafer support region 116 and the back wall 104 and the side walls 102, it is to be understood that implementations where there are small perforations or gaps in the support fin 110 between the wafer support region 116 and the back wall 104 and side walls 102 may also fall within the scope of this disclosure.", "In such additional implementations, there may still be substantially no inter-wafer purge gas flow, i.e., the amount of purge gas flow across each wafer/support fin is at least three orders of magnitude or more greater than the amount of inter-wafer purge gas flow from that wafer/support fin.", "FIG.", "5 depicts an isometric section view of the buffer of FIG.", "1.Arrows have also been added to this view to show purge gas flow, although only for three of the wafer/support fin levels (to avoid undue clutter—similar gas flows, however, would occur for each wafer/support fin level).", "As can be seen, purge gas flows generally in a linear direction towards the opening 114.Since the edge of the “shelf” formed by each wafer 118 and its supporting support fin 110 near the opening does not form a straight line all the way across due to the cutout region throat 144, some of the purge gas may flow off of the support fin 110 or wafer 118 into the notch formed by the intersection of the wafer 118 outer edge and the edge of the support fin 110 facing the opposing side wall 102.FIG.", "6 depicts a plan section view of the buffer of FIG.", "1.FIG.", "7 depicts an isometric plan section view of the buffer of FIG.", "1.One of the linear arrays of purge gas ports 124 is clearly visible in FIGS.", "6 and 7.In this example, there are 10 purge gas ports 124 arranged in an equally-spaced linear array.", "However, more or fewer such purge gas ports 124 may be used.", "In an extreme case, there may be a single purge gas port that extends across most of the back wall 104, e.g., a long, thin slit through which the purge gas may flow.", "FIG.", "8 depicts a plan section view of the buffer of FIG.", "1 without any wafers present.", "FIG.", "9 depicts an isometric plan section view of the buffer of FIG.", "1 without any wafers present.", "FIGS.", "8 and 9 are included to more clearly depict the wafer support region, which is indicated in these Figures by wafer support region 116.Also shown is cutout region 120, of which cutout region throat 144 forms a part.", "While buffers such as the buffer 100 described above may provide a mechanism for protecting wafers 118 from non-inert environments, situating such buffers in a particular manner may provide further protection from contamination.", "One such particular manner is to situate the buffer in a housing that is configured to cause filtered air to be directed across the opening 114 in a direction generally perpendicular to the wafers 118.FIG.", "10 depicts an isometric view of a buffer installed into a housing that is configured to direct clean air across the front of the buffer.", "FIG.", "11 depicts an isometric section view of the buffer and housing of FIG.", "10.FIG.", "12 depicts an isometric exploded section view of the buffer and housing of FIG.", "10.Grey arrows have been added to FIGS.", "10, 11, and 12 to indicate the flow of filtered air.", "Such air is typically flowed from vents in the ceiling of an EFEM towards exhaust ports located in the floor of the EFEM.", "In the case of the housing 154 (see FIG.", "12), the housing 154 is shaped to control the flow of filtered air that is supplied from a clean air inlet 134 positioned above the buffer 100 such that the filtered air is prevented from impacting the ceiling or lid 106 of the buffer 100 and is instead routed down the front of the buffer, across the opening 114.Side baffles 150 and front baffles further serve to shape the filtered air flow into a column that flows across the opening 114.This columnar filtered air flow is further encouraged by the addition of an exhaust port 132 located at the base of the opening 114 and extending several inches beyond the front of the buffer 100.The exhaust port 132 may be fluidically connected with an interior plenum of the housing (see section view in FIG.", "11); an exhaust grating 146 may be used as a baffle to assist in evening out exhaust flow distribution.", "The gas that is sucked into the exhaust port 132 may be flowed out of an exhaust vent port 148 that delivers the gas to a scrubber system or other safe disposal system.", "By including an additional exhaust port directly in front of the buffer, columnar flow of filtered air across the opening is encouraged.", "Such columnar flow has the effect of sucking the purge gas that flows horizontally off the edge of each “ledge” into a vertical flow column, where it is then evacuated as part of the exhaust stream.", "This also helps protect the other equipment in the EFEM from contamination by chemicals that are entrained in the purge gas.", "FIG.", "13 depicts a plan view of an EFEM with two buffers installed.", "Visible in FIG.", "13 is EFEM 156, which is designed to accommodate three FOUPs 158 and which has two buffer units 100, as described herein.", "A wafer handling robot 160 with an end effector 162 (a single-arm robot is shown, but a multi-arm/multi-end-effector robot or multiple robots may be used as well, however) may be located within the EFEM 156 and used to transport wafers between the FOUPs 158, the buffers 100, and loadlocks 164.The loadlocks 164 may be connected to a transfer chamber or process chamber.", "FIG.", "14 depicts a top section view of an example buffer similar to the buffer shown in FIG.", "1.A buffer 1400 that has a rectangular (in this case, nearly square) cross-sectional profile is shown.", "The buffer 1400 has a back wall 1404, side walls 1402, and an opening opposite the back wall.", "A support fin 1410 extends from the back wall 1404 and the side walls 1402 past the exterior diameter of a wafer 1418 (shown using a dashed circle, in this example).", "In this example, the support fin 1410 extends up to a circular cutout region 1420 with a rectangular cutout region throat 1444.The cutout region throat 1444 is wide enough to allow an end effector 1462 (dotted outline) of a wafer handling robot (not shown) to be inserted into the buffer 1400.A wafer support region 1416 is defined between the outer edge of the cutout region 1420 and a circular boundary around the wafer 1418 and having a diameter at least as large as the wafer 1418.FIG.", "15 depicts a top section view of another example buffer.", "A buffer 1500 that has a rectangular (in this case, nearly square) cross-sectional profile is shown.", "The buffer 1500 has a back wall 1504, side walls 1502, and an opening opposite the back wall.", "A support fin 1510 extends from the back wall 1504 and the side walls 1502 past the exterior diameter of a wafer 1518 (shown using a dashed circle, in this example).", "In this example, the support fin 1510 extends up to a slot-shaped cutout region 1520 that has a rounded innermost surface (other shapes are also possible, however, depending on the desires of the designer).", "In this example, the cutout region 1520 has a cutout region throat 1544 that is, in essence, the same width as the cutout region 1520.The cutout region throat 1544 is wide enough to allow an end effector 1562 (dotted outline) of a wafer handling robot (not shown) to be inserted into the buffer 1500.A wafer support region 1516 is defined between the outer edge of the cutout region 1520 and a circular boundary around the wafer 1518 and having a diameter at least as large as the wafer 1518.FIG.", "16 depicts a top section view of yet another example buffer.", "A buffer 1600 that has a rectangular (in this case, nearly square) cross-sectional profile is shown.", "The buffer 1600 has a back wall 1604, side walls 1602, and an opening opposite the back wall.", "A support fin 1610 extends from the back wall 1604 and the side walls 1602 past the exterior diameter of a wafer 1618 (shown using a dashed circle, in this example).", "In this example, the support fin 1610 extends up to a slot-shaped cutout region 1620 that has a rounded innermost surface (other shapes are also possible, however, depending on the desires of the designer).", "As with the previous example buffer 1500, the cutout region 1620 has a cutout region throat 1644 that is, in essence, the same width as the cutout region 1620.The cutout region throat 1644 is wide enough to allow an end effector 1662 (dotted outline) of a wafer handling robot (not shown) to be inserted into the buffer 1600.In this example, however, the end effector is wider than in the prior example, and the cutout region throat 1644 is just slightly smaller than the diameter of the wafer 1618.A wafer support region 1616 is defined between the outer edge of the cutout region 1620 and a circular boundary around the wafer 1618 and having a diameter at least as large as the wafer 1618.The wafer support region 1616 only overlaps with just over 50% of the outer perimeter of the wafer 1618, as compared with the wafer support region 1516's overlap with over 75% of the outer perimeter of the wafer 1518, but such a reduced overlap may still provide acceptable performance according to the principles discussed herein.", "As discussed previously, while the example buffers discussed above have primarily had rectangular cross-sections in the plan view, buffers with other cross-sectional profiles may also be implemented using the techniques discussed herein.", "FIG.", "17 depicts a top sectional view of a buffer with a hexagonal cross-section.", "Such a buffer 1700 may be provided, as illustrated, by chamfering a back wall 1704 such that the back corners of the buffer 1700 are removed (or at least replaced with corners greater than 90 degrees in included angle).", "Side walls 1702 may, in such designs, only extend a small distance beyond the center of whatever wafers are inserted into the buffer 1700.This may have the effect of reducing the surface area of support fin 1710 (the cutout region 1720, cutout region throat 1744, and wafer support region 1716 are substantially identical, in this case, to the corresponding structures in FIG.", "14), and may reduce the amount of dead space that is present in the buffer 1700.FIG.", "18 depicts a top sectional view of a buffer with a cylindrical back wall.", "Such a buffer 1800 may be provided, as illustrated, by shaping a back wall 1804 such that it is the shape of a half-cylinder.", "Side walls 1802 may, in such designs, only extend a small distance beyond the center of whatever wafers are inserted into the buffer 1800.Such an implementation may further act to reduce the potential dead space within the buffer 1800 as compared with buffer 1700 (the cutout region 1820, cutout region throat 1844, and wafer support region 1816 are, as with the prior example, substantially identical to the corresponding structures in FIG.", "14).", "FIGS.", "14 through 18 represent only some of the different ways that the concepts and principles discussed herein may be implemented to provide a buffer.", "It is to be understood that other implementations may depart from the depicted examples but still fall within the scope of this disclosure, and that this disclosure is not to be limited to only the examples provided.", "The side walls, back wall, and support fins of buffers designed according to the principles discussed herein may be manufactured in a number of different ways.", "For example, the side walls, back wall, and support fins may be cast as a single, monolithic part and the purge gas ports and wafer support features may then be machined into the cast part.", "In another implementation, the side walls, back wall, and support fins may be assembled by stacking together a large number of horizontal cross-sectional pieces, e.g., horizontal cross-sections of the side walls and back wall without the support fins alternating with horizontal cross-sections of the side walls and back wall with the support fins.", "This may allow the buffer to be expanded or reduced in size without needing to produce an entirely new buffer (further cross-sectional pieces may be added or cross-sectional pieces removed to increase or decrease the number of wafers that may be supported within the buffer).", "These, and other, manufacturing techniques may be used to construct the side walls, back wall, and support fin structures.", "The buffer structures may be made of any suitable material, such as, for example, an aluminum alloy.", "The wafer support features may be provided by small features machined into the support fins, or by small components attached to the support fins, e.g., pins, standoffs, or small, stainless steel balls that are press-fit into holes in the support fins.", "FIGS.", "19 through 22 depict another example of a buffer embodying the concepts discussed herein.", "FIG.", "19 depicts an exploded isometric view of this second example buffer.", "FIG.", "20 depicts an isometric section view of the example buffer of FIG.", "19.FIG.", "21 depicts another isometric section view of the example buffer of FIG.", "19.FIG.", "22 depicts a top section view of the example buffer of FIG.", "19.Visible in FIGS.", "19 through 22 is buffer 2100, which has a shape similar to the buffer of FIG.", "1700.As can be seen, the buffer 2100 has two side walls 2102 and a back wall 2104 with three segments (one perpendicular to the side walls 2102, and flanking segments at 45 degrees to the side walls 2102), as well as a floor 2108 and a ceiling 2106.In this implementation, all of the side walls 2102 and back wall 2104 contain plenum cavities 2130, which are capped by plenum covers 2128.Each plenum cavity 2130 has a plurality of purge gas ports 2124; the purge gas ports 2124 are arranged such that purge gas is directed from subsets of the purge gas ports 2124 between each pair of wafers 2118.The wafers 2118 may be supported on pegs 2144 that project radially inward from the interior surface of support fins 2110.The buffer 2100 is different from the buffer 100 in that there is an exhaust port 2132 located in the floor 2108, rather than in front of the buffer.", "However, just like in the buffer 100, purge gas that is introduced into the inter-wafer spaces through the purge gas ports 2124 is constrained by the wafers 2118 and the support fins 2110 such that it flows towards the opening 2114 (the opening 2114 is indicated in higher fidelity than the opening 114, which is represented in the simplified form of a plane).", "This prevents ambient air from the surrounding environment from being drawn into the inter-wafer spaces.", "The purge gas, after reaching the edge of the wafers closest to the opening 2114, is then drawn downwards (essentially along the opening 2114 boundary) towards the exhaust port 2132.Any residuals from the wafers 2118 that are entrained in the purge gas will thus be drawn into the exhaust port 2132.As is visible in the detail view FIG.", "19′, the support fins 2110 in buffer 2100 are of a slightly different design than in buffer 100.In buffer 2100, the cutout region 2120 (see FIG.", "22) has a circular portion that is slightly larger in diameter than the wafer 2118, resulting in a small radial gap between the support fins 2110 and the wafer 2118 about the periphery of the wafer 2118.Instead of being supported by resting on the upper surface of the support fin 2110, wafers 2118 may be supported by pegs 2144 that protrude into the cutout region 2120 from the interior surface of the support fins 2110.The pegs 2144 may include a rod portion with an expanded-diameter portion, e.g., a spherical knob, that is designed to contact the wafers 2118.As can be seen, the radial gaps formed between the wafers 2118 and the support fins 2110 offer a less tortuous path than the wafer support region of the support fins 110.However, the bulk of the purge gas flow within the buffer 2100 will still be towards the opening 2114.In such an implementation, the wafer support region may be viewed as being an annular area that includes the pegs 2144 within its area.", "It is also to be understood that the buffers described herein may be combined with various configurations of filtered air and exhaust systems.", "Furthermore, it is to be understood that the “filtered air” may also be replaced with other gases, e.g., an inert gas (at least, from a wafer chemistry standpoint) such as nitrogen may be supplied via the filtered or clean “air” inlet, forming a curtain of purge gas in front of the buffer opening.", "Following are a several, non-exhaustive examples of potential filtered air inlet/exhaust port configurations that may be used.", "FIG.", "23 depicts a front view of a buffer with a side-mounted exhaust and side-mounted filtered air inlet.", "As can be see, in this configuration, a clean air (or purge gas) curtain flows across buffer 2300 from filtered air inlet 2334 to exhaust port 2332 (left to right); the direction, of course, may also be reversed from the direction shown, if desired.", "If two buffers 2300 are located adjacent to one another, then the filtered air inlet 2334 may be interposed between them and exhaust ports 2332 may be placed on opposing sides of the buffers 2300, allowing a common filtered air inlet 2334 to provide a gas curtain across two separate buffers 2300.FIG.", "24 depicts a front view of a buffer with bottom-mounted exhaust and a top-mounted filtered air inlet.", "This implementation, in which filtered air (or purge gas) is flowed from a filtered air inlet 2434 mounted above a buffer 2400 into an exhaust port 2432 mounted below the buffer 2400, corresponds generally with the arrangement shown in FIGS.", "10 through 12.FIG.", "25 depicts a front view of a buffer with top-mounted filtered air inlet and side- and bottom-mounted exhausts.", "Finally, as can be seen in FIG.", "25, another configuration that may be used is to have both side- and bottom-mounted exhaust ports 2532 draw air from a top-mounted filtered air inlet 2534.This may prove to provide an even more effective barrier against accidentally drawing EFEM mini-environment air into the buffer 2500.It is to be understood that the buffers and housings described above may also include other or additional components, e.g., centering/buffer-locating features, temperature sensors, humidity sensors, etc.", "For example, a buffer such as those described herein may be implemented so as to be easily removable from an EFEM for rapid inspection and cleaning (or replacement), and may have features on the underside of the floor that allow the EFEM to be rapidly positioned with respect to the EFEM.", "The use of relative positioning terms such as “above” and “below” within this specification are used in their typical senses.", "The term “front,” when used with respect to the buffer, refers to the portion of the buffer through which wafers are inserted during normal use.", "The term “back” refers to the portion of the buffer on the opposite side from the front.", "It will also be understood that unless features in any of the particular described implementations are expressly identified as incompatible with one another or the surrounding context implies that they are mutually exclusive and not readily combinable in a complementary and/or supportive sense, the totality of this disclosure contemplates and envisions that specific features of those complementary implementations can be selectively combined to provide one or more comprehensive, but slightly different, technical solutions.", "It will therefore be further appreciated that the above description has been given by way of example only and that modifications in detail may be made within the scope of the invention." ] ]
Patent_15875917
[ [ "INDUCTION OF PLURIPOTENT CELLS", "The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications.", "Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment.", "This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells." ], [ "1-37.", "(canceled) 38.A method of inducing non-pluripotent mammalian cells into induced pluripotent stem cells, comprising: (a) introducing Oct-3/4, and optionally, one or both of Klf and Sox2, into the non-pluripotent cells; and (b) contacting the non-pluripotent cells with a mixture comprising an ALK5 inhibitor, a MEK inhibitor, and a ROCK inhibitor, wherein the ALK5 inhibitor, the MEK inhibitor, and the ROCK inhibitor increase efficiency of inducing the non-pluripotent mammalian cells into induced pluripotent stem cells, as compared to non-pluripotent mammalian cells treated with the ALK5 inhibitor and the MEK inhibitor without the ROCK inhibitor.", "39.The method of claim 38, wherein the introducing step comprises introducing a polynucleotide encoding Oct-3/4, and optionally, one or both of K14 and Sox2 operably linked to a regulatory sequence into the non-pluripotent cells, wherein the polynucleotide is expressed in the non-pluripotent cells.", "40.The method of claim 38, wherein the introducing step comprises contacting the non-pluripotent cells with Oct-3/4, Klf4, Sox2, and optionally c-Myc polypeptides.", "41.The method of claim 38, further comprising contacting the non-pluripotent cells with a glycogen synthase kinase 3 (GSK3) inhibitor.", "42.The method of claim 38, further comprising contacting the non-pluripotent cells with a histone deacetylase (HDAC) inhibitor.", "43.The method of claim 38, wherein the mammalian cells are human cells.", "44.A therapeutic composition comprising (i) an induced pluripotent stem cell reprogrammed from a mammalian non-pluripotent cell, and (ii) a mixture comprising: an ALK5 inhibitor; a MEK inhibitor; and a ROCK inhibitor.", "45.The therapeutic composition of claim 44, wherein the mixture further comprises a GSK3 inhibitor.", "46.The therapeutic composition of claim 44, wherein the mammalian cell is a human cell.", "47.The therapeutic composition of claim 44, wherein the induced pluripotent stem cell is reprogrammed by introducing into the mammalian non-pluripotent cell an exogenous Oct4 encoding polynucleotide and Klf encoding polynucleotide to initiate reprogramming.", "48.A method of using the therapeutic composition of claim 44 by administering the composition to a subject suitable for such treatment.", "49.The method of claim 48, wherein the therapeutic composition comprises cells that are allogenic or autogenic.", "50.A kit comprising (i) an induced pluripotent stem cell reprogrammed from a mammalian non-pluripotent cell, and (ii) a mixture comprising: an ALK5 inhibitor; a MEK inhibitor; and a ROCK inhibitor.", "51.The kit of claim 50, wherein the mammalian cell is a human cell.", "52.A kit comprising differentiated cells of a desired cell type derived from induced mammalian pluripotent stem (iPS) cells, wherein the iPS cells are comprised in a mixture comprising an ALK5 inhibitor; a MEK inhibitor; and a ROCK inhibitor.", "53.The kit of claim 52, wherein the mammalian cells are human cells." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Recent advances in generating human induced pluripotent stem cells (iPSCs) (Takahashi, K. et al., Cell 131, 861-72 (2007); Yu, J. et al., Science 318, 1917-20 (2007); Muller, L. U. W., et al., Mol.", "Ther.", "17, 947-53 (2009)) have raised hopes for their utility in biomedical research and clinical applications.", "However, iPSC generation is still a very slow (˜4 weeks) and inefficient (<0.01% (Takahashi, K. et al., Cell 131, 861-72 (2007); Yu, J. et al., Science 318, 1917-20 (2007)) process that results in a heterogeneous population of cells.", "Identifying fully reprogrammed iPSCs from such a mixture is tedious, and requires specific expertise in human pluripotent cell culture.", "Although the dangers of genomic insertion of exogenous reprogramming factors is being overcome, the low efficiency and slow kinetics of reprogramming continue to present a formidable problem for ultimate applications of human iPSC.", "For example, an increase in genetic or epigenetic abnormalities could occur during the reprogramming process, where tumor suppressors may be inhibited and oncogenic pathways may be activated.", "Though recent studies have reported an improved efficiency of reprogramming by genetic manipulations (Feng, B. et al., Cell Stem Cell 4, 301-12 (2009)) in addition to the original four factors, such manipulations typically make the process even more complex and increase the risk of genetic alterations and tumorigenicity.", "Thus, there is still a tremendous need for a safer, easier and more efficient procedure for human iPSC generation and facilitate identifying and characterizing fundamental mechanisms of reprogramming." ], [ "<SOH> BRIEF SUMMARY OF THE INVENTION <EOH>The present invention provides for mixtures (e.g., useful for inducing iPSCs).", "In some embodiments, the mixture comprises: mammalian cells; a TGFβ receptor/ALK5 inhibitor; a MEK inhibitor; and a Rho GTPase/ROCK pathway inhibitor.", "In some embodiments, at least 99% of the cells are non-pluripotent cells.", "In some embodiments, all or essentially all of the cells are non-pluripotent cells.", "In some embodiments, the cells are human cells.", "In some embodiments, the TGFβ receptor/ALK5 inhibitor is SB431542.In some embodiments, the MEK inhibitor is PD0325901.In some embodiments, the ROCK inhibitor is a compound having the formula: ring A is a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; ring B is a substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl; L 1 is —C(O)—NR 2 — or —C(O)—NR 2 —; L 2 is a bond, substituted or unsubstituted alkylene or substituted or unsubstituted heteroalkylene; and R 1 and R 2 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl In some embodiments, the ROCK inhibitor has the formula: wherein, y is an integer from 0 to 3; z is an integer from 0 to 5; X is —N═, —CH═ or —CR 5 ═; R 3 , R 4 and R 5 are independently CN, S(O)nR 6 , NR 7 R 8 , C(O)R 9 , NR 10 —C(O)R 11 , NR 12 —C(O)—OR 13 , —C(O)NR 14 R 15 , —NR 16 S(O)2R 17 , —OR 18 , —S(O)2NR 19 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein n is an integer from 0 to 2, wherein if z is greater than 1, two R 3 moieties are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 and R 19 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.", "In some embodiments, the ROCK inhibitor has the formula: In some embodiments, the ROCK inhibitor is In some embodiments, the concentration of the inhibitors is sufficient to improve by at least 10% the efficiency of induction of non-pluripotent cells in the mixture into induced pluripotent stem cells when the mixture is submitted to conditions sufficient to induce conversion of the cells into induced pluripotent stem cells.", "In some embodiments, the mixture further comprises a GSK3 inhibitor and/or HDAC inhibitor.", "In some embodiments, the polypeptides are selected from Oct-3/4, Sox2, KLF4 and c-Myc.", "In some embodiments, the cells are selected from human cell, non-human animal cells, mouse cells, non-human primates, or other animal cells.", "The present invention also provides methods of inducing non-pluripotent mammalian cells into induced pluripotent stem cells.", "In some embodiments, the method comprises contacting non-pluripotent cells with: a TGFβ receptor/ALK5 inhibitor; a MEK inhibitor; and a ROCK inhibitor, under conditions sufficient to induce at least some cells to become pluripotent stem cells.", "In some embodiments, the conditions comprise introducing at least one exogenous transcription factor into the non-pluripotent cells.", "In some embodiments, the at least one exogenous transcription factor is an Oct polypeptide and the cells are further contacted with a histone deacetylase (HDAC) inhibitor.", "In some embodiments, the transcription factor is selected from the group consisting of an Oct polypeptide, a Klf polypeptide, a Myc polypeptide, and a Sox polypeptide.", "In some embodiments, the method comprises introducing at least two, three or four exogenous transcription factor into the non-pluripotent cells, wherein the transcription factors are selected from the group consisting of an Oct polypeptide, a Klf polypeptide, a Myc polypeptide, and a Sox polypeptide.", "In some embodiments, the polypeptides are selected from Oct-3/4, Sox2, KLF4 and c-Myc.", "In some embodiments, the cells are selected from human cell, non-human animal cells, mouse cells, non-human primates, or other animal cells.", "In some embodiments, the at least one transcription factor is introduced by introducing a polynucleotide into the non-pluripotent cells, wherein the polynucleotide encodes the at least one exogenous transcription factor, thereby expressing the transcription factor(s) in the cells.", "In some embodiments, the at least one transcription factor is introduced by contacting an exogenous polypeptide to the non-pluripotent cells, wherein the polypeptide comprises the amino acid sequence of the transcription factor, wherein the introduction is performed under conditions to introduce the polypeptide into the cells.", "In some embodiments, the polypeptide comprises an amino acid sequence that enhances transport across cell membranes.", "In some embodiments, the cells are human cells.", "In some embodiments, the TGFβ receptor/ALK5 inhibitor is SB431542.In some embodiments, the MEK inhibitor is PD0325901 In some embodiments, the ROCK inhibitor is a compound having the formula: ring A is a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; ring B is a substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl; L 1 is —C(O)—NR 2 — or —C(O)—NR 2 —; L 2 is a bond, substituted or unsubstituted alkylene or substituted or unsubstituted heteroalkylene; and R 1 and R 2 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.", "In some embodiments, the ROCK inhibitor has the formula: wherein, y is an integer from 0 to 3; z is an integer from 0 to 5; X is —N═, —CH═ or —CR 5 ═; R 3 , R 4 and R 5 are independently CN, S(O)nR 6 , NR 7 R 8 , C(O)R 9 , NR 10 —C(O)R 11 , NR 12 —C(O)—OR 13 , —C(O)NR 14 R 15 , —NR 16 S(O)2R 17 , —OR 18 , —S(O)2NR 19 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein n is an integer from 0 to 2, wherein if z is greater than 1, two R 3 moieties are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 and R 19 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.", "In some embodiments, the ROCK inhibitor has the formula: In some embodiments, the ROCK inhibitor is In some embodiments, the concentration of the inhibitors is sufficient to improve by at least 10% the efficiency of induction of non-pluripotent cells in the mixture into induced pluripotent stem cells, when the mixture is subjected to conditions sufficient to induce conversion of the cells into induced pluripotent stem cells.", "In some embodiments, the mixture further comprises a GSK3 inhibitor.", "The present invention also provides for kits for inducing pluripotency in non-pluripotent mammalian cells.", "In some embodiments, the kit comprises, a TGFβ receptor/ALK5 inhibitor; a MEK inhibitor; and a ROCK inhibitor.", "In some embodiments, the TGFβ receptor/ALK5 inhibitor is SB431542.In some embodiments, the MEK inhibitor is PD0325901.In some embodiments, the ROCK inhibitor is a compound having the formula: ring A is a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; ring B is a substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl; L 1 is —C(O)—NR 2 — or —C(O)—NR 2 —; L 2 is a bond, substituted or unsubstituted alkylene or substituted or unsubstituted heteroalkylene; and R 1 and R 2 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl In some embodiments, the ROCK inhibitor has the formula: wherein, y is an integer from 0 to 3; z is an integer from 0 to 5; X is —N═, —CH═ or —CR 5 ═; R 3 , R 4 and R 5 are independently CN, S(O)nR 6 , NR 7 R 8 , C(O)R 9 , NR 10 —C(O)R 11 , NR 12 —C(O)—OR 13 , —C(O)NR 14 R 15 , —NR 16 S(O)2R 17 , —OR 18 , —S(O)2NR 19 , substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein n is an integer from 0 to 2, wherein if z is greater than 1, two R 3 moieties are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 and R 19 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.", "In some embodiments, the ROCK inhibitor has the formula: In some embodiments, the ROCK inhibitor is In some embodiments, the kit further comprises a GSK3 inhibitor and/or a histone deacetylase (HDAC) inhibitor.", "Other embodiments will be clear from the remainder of this disclosure." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. application Ser.", "No.", "14/637,089, filed Mar.", "3, 2015, which is a continuation of U.S. application Ser.", "No.", "13/500,373, filed Jun.", "26, 2012, issued as U.S. Pat.", "No.", "9,005,968, which is a U.S. National Stage application under 35 U.S.C.", "§ 371 of International Application No.", "PCT/US2010/052896, filed Oct. 15, 2010, which claims priority to U.S.", "Provisional Application No.", "61/252,548, filed Oct. 16, 2009, the contents of each of which are incorporated by reference in their entirety.", "STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT This invention was made with government support under Contract No.", "HD-058110 awarded by the National Institutes of Health.", "The government has certain rights in the invention.", "REFERENCE TO A “SEQUENCE LISTING,” A TABLE, OR A COMPUTER PROGRAM LISTING APPENDIX SUBMITTED AS AN ASCII TEXT FILE The Sequence Listing written in file SEQTXT_77103-003820US-930402.txt, created on Mar.", "2, 2015, 9,986 bytes, machine format IBM-PC, MS-Windows operating system, is hereby incorporated by reference in its entirety for all purposes.", "BACKGROUND OF THE INVENTION Recent advances in generating human induced pluripotent stem cells (iPSCs) (Takahashi, K. et al., Cell 131, 861-72 (2007); Yu, J. et al., Science 318, 1917-20 (2007); Muller, L. U. W., et al., Mol.", "Ther.", "17, 947-53 (2009)) have raised hopes for their utility in biomedical research and clinical applications.", "However, iPSC generation is still a very slow (˜4 weeks) and inefficient (<0.01% (Takahashi, K. et al., Cell 131, 861-72 (2007); Yu, J. et al., Science 318, 1917-20 (2007)) process that results in a heterogeneous population of cells.", "Identifying fully reprogrammed iPSCs from such a mixture is tedious, and requires specific expertise in human pluripotent cell culture.", "Although the dangers of genomic insertion of exogenous reprogramming factors is being overcome, the low efficiency and slow kinetics of reprogramming continue to present a formidable problem for ultimate applications of human iPSC.", "For example, an increase in genetic or epigenetic abnormalities could occur during the reprogramming process, where tumor suppressors may be inhibited and oncogenic pathways may be activated.", "Though recent studies have reported an improved efficiency of reprogramming by genetic manipulations (Feng, B. et al., Cell Stem Cell 4, 301-12 (2009)) in addition to the original four factors, such manipulations typically make the process even more complex and increase the risk of genetic alterations and tumorigenicity.", "Thus, there is still a tremendous need for a safer, easier and more efficient procedure for human iPSC generation and facilitate identifying and characterizing fundamental mechanisms of reprogramming.", "BRIEF SUMMARY OF THE INVENTION The present invention provides for mixtures (e.g., useful for inducing iPSCs).", "In some embodiments, the mixture comprises: mammalian cells; a TGFβ receptor/ALK5 inhibitor; a MEK inhibitor; and a Rho GTPase/ROCK pathway inhibitor.", "In some embodiments, at least 99% of the cells are non-pluripotent cells.", "In some embodiments, all or essentially all of the cells are non-pluripotent cells.", "In some embodiments, the cells are human cells.", "In some embodiments, the TGFβ receptor/ALK5 inhibitor is SB431542.In some embodiments, the MEK inhibitor is PD0325901.In some embodiments, the ROCK inhibitor is a compound having the formula: ring A is a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; ring B is a substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl; L1 is —C(O)—NR2— or —C(O)—NR2—; L2 is a bond, substituted or unsubstituted alkylene or substituted or unsubstituted heteroalkylene; and R1 and R2 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl In some embodiments, the ROCK inhibitor has the formula: wherein, y is an integer from 0 to 3; z is an integer from 0 to 5; X is —N═, —CH═ or —CR5═; R3, R4 and R5 are independently CN, S(O)nR6, NR7R8, C(O)R9, NR10—C(O)R11, NR12—C(O)—OR13, —C(O)NR14R15, —NR16S(O)2R17, —OR18, —S(O)2NR19, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein n is an integer from 0 to 2, wherein if z is greater than 1, two R3 moieties are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18 and R19 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.", "In some embodiments, the ROCK inhibitor has the formula: In some embodiments, the ROCK inhibitor is In some embodiments, the concentration of the inhibitors is sufficient to improve by at least 10% the efficiency of induction of non-pluripotent cells in the mixture into induced pluripotent stem cells when the mixture is submitted to conditions sufficient to induce conversion of the cells into induced pluripotent stem cells.", "In some embodiments, the mixture further comprises a GSK3 inhibitor and/or HDAC inhibitor.", "In some embodiments, the polypeptides are selected from Oct-3/4, Sox2, KLF4 and c-Myc.", "In some embodiments, the cells are selected from human cell, non-human animal cells, mouse cells, non-human primates, or other animal cells.", "The present invention also provides methods of inducing non-pluripotent mammalian cells into induced pluripotent stem cells.", "In some embodiments, the method comprises contacting non-pluripotent cells with: a TGFβ receptor/ALK5 inhibitor; a MEK inhibitor; and a ROCK inhibitor, under conditions sufficient to induce at least some cells to become pluripotent stem cells.", "In some embodiments, the conditions comprise introducing at least one exogenous transcription factor into the non-pluripotent cells.", "In some embodiments, the at least one exogenous transcription factor is an Oct polypeptide and the cells are further contacted with a histone deacetylase (HDAC) inhibitor.", "In some embodiments, the transcription factor is selected from the group consisting of an Oct polypeptide, a Klf polypeptide, a Myc polypeptide, and a Sox polypeptide.", "In some embodiments, the method comprises introducing at least two, three or four exogenous transcription factor into the non-pluripotent cells, wherein the transcription factors are selected from the group consisting of an Oct polypeptide, a Klf polypeptide, a Myc polypeptide, and a Sox polypeptide.", "In some embodiments, the polypeptides are selected from Oct-3/4, Sox2, KLF4 and c-Myc.", "In some embodiments, the cells are selected from human cell, non-human animal cells, mouse cells, non-human primates, or other animal cells.", "In some embodiments, the at least one transcription factor is introduced by introducing a polynucleotide into the non-pluripotent cells, wherein the polynucleotide encodes the at least one exogenous transcription factor, thereby expressing the transcription factor(s) in the cells.", "In some embodiments, the at least one transcription factor is introduced by contacting an exogenous polypeptide to the non-pluripotent cells, wherein the polypeptide comprises the amino acid sequence of the transcription factor, wherein the introduction is performed under conditions to introduce the polypeptide into the cells.", "In some embodiments, the polypeptide comprises an amino acid sequence that enhances transport across cell membranes.", "In some embodiments, the cells are human cells.", "In some embodiments, the TGFβ receptor/ALK5 inhibitor is SB431542.In some embodiments, the MEK inhibitor is PD0325901 In some embodiments, the ROCK inhibitor is a compound having the formula: ring A is a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; ring B is a substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl; L1 is —C(O)—NR2— or —C(O)—NR2—; L2 is a bond, substituted or unsubstituted alkylene or substituted or unsubstituted heteroalkylene; and R1 and R2 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.", "In some embodiments, the ROCK inhibitor has the formula: wherein, y is an integer from 0 to 3; z is an integer from 0 to 5; X is —N═, —CH═ or —CR5═; R3, R4 and R5 are independently CN, S(O)nR6, NR7R8, C(O)R9, NR10—C(O)R11, NR12—C(O)—OR13, —C(O)NR14R15, —NR16S(O)2R17, —OR18, —S(O)2NR19, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein n is an integer from 0 to 2, wherein if z is greater than 1, two R3 moieties are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18 and R19 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.", "In some embodiments, the ROCK inhibitor has the formula: In some embodiments, the ROCK inhibitor is In some embodiments, the concentration of the inhibitors is sufficient to improve by at least 10% the efficiency of induction of non-pluripotent cells in the mixture into induced pluripotent stem cells, when the mixture is subjected to conditions sufficient to induce conversion of the cells into induced pluripotent stem cells.", "In some embodiments, the mixture further comprises a GSK3 inhibitor.", "The present invention also provides for kits for inducing pluripotency in non-pluripotent mammalian cells.", "In some embodiments, the kit comprises, a TGFβ receptor/ALK5 inhibitor; a MEK inhibitor; and a ROCK inhibitor.", "In some embodiments, the TGFβ receptor/ALK5 inhibitor is SB431542.In some embodiments, the MEK inhibitor is PD0325901.In some embodiments, the ROCK inhibitor is a compound having the formula: ring A is a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; ring B is a substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl; L1 is —C(O)—NR2— or —C(O)—NR2—; L2 is a bond, substituted or unsubstituted alkylene or substituted or unsubstituted heteroalkylene; and R1 and R2 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl In some embodiments, the ROCK inhibitor has the formula: wherein, y is an integer from 0 to 3; z is an integer from 0 to 5; X is —N═, —CH═ or —CR5═; R3, R4 and R5 are independently CN, S(O)nR6, NR7R8, C(O)R9, NR10—C(O)R11, NR12—C(O)—OR13, —C(O)NR14R15, —NR16S(O)2R17, —OR18, —S(O)2NR19, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein n is an integer from 0 to 2, wherein if z is greater than 1, two R3 moieties are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18 and R19 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.", "In some embodiments, the ROCK inhibitor has the formula: In some embodiments, the ROCK inhibitor is In some embodiments, the kit further comprises a GSK3 inhibitor and/or a histone deacetylase (HDAC) inhibitor.", "Other embodiments will be clear from the remainder of this disclosure.", "Definitions An “Oct polypeptide” refers to any of the naturally-occurring members of Octamer family of transcription factors, or variants thereof that maintain transcription factor activity, similar (within at least 50%, 80%, or 90% activity) compared to the closest related naturally occurring family member, or polypeptides comprising at least the DNA-binding domain of the naturally occurring family member, and can further comprise a transcriptional activation domain.", "Exemplary Oct polypeptides include, Oct-1, Oct-2, Oct-3/4, Oct-6, Oct-7, Oct-8, Oct-9, and Oct-11.e.g.", "Oct3/4 (referred to herein as “Oct4”) contains the POU domain, a 150 amino acid sequence conserved among Pit-1, Oct-1, Oct-2, and uric-86.See, Ryan, A. K. & Rosenfeld, M. G. Genes Dev.", "11, 1207-1225 (1997).", "In some embodiments, variants have at least 85%, 90%, or 95% amino acid sequence identity across their whole sequence compared to a naturally occurring Oct polypeptide family member such as to those listed above or such as listed in Genbank accession number NP 002692.2 (human Oct4) or NP_038661.1 (mouse Oct4).", "Oct polypeptides (e.g., Oct3/4) can be from human, mouse, rat, bovine, porcine, or other animals.", "Generally, the same species of protein will be used with the species of cells being manipulated.", "A “Klf polypeptide” refers to any of the naturally-occurring members of the family of Krüppel-like factors (Klfs), zinc-finger proteins that contain amino acid sequences similar to those of the Drosophila embryonic pattern regulator Krüppel, or variants of the naturally-occurring members that maintain transcription factor activity similar (within at least 50%, 80%, or 90% activity) compared to the closest related naturally occurring family member, or polypeptides comprising at least the DNA-binding domain of the naturally occurring family member, and can further comprise a transcriptional activation domain.", "See, Dang, D. T., Pevsner, J.", "& Yang, V. W. Cell Biol.", "32, 1103-1121 (2000).", "Exemplary Klf family members include, Klf1, Klf2, Klf3, Klf-4, Klf5, Klf6, Klf7, Klf8, Klf9, Klf10, Klf11, Klf12, Klf13, Klf14, Klf15, Klf16, and Klf17.Klf2 and Klf-4 were found to be factors capable of generating iPS cells in mice, and related genes Klf1 and Klf5 did as well, although with reduced efficiency.", "See, Nakagawa, et al., Nature Biotechnology 26:101-106 (2007).", "In some embodiments, variants have at least 85%, 90%, or 95% amino acid sequence identity across their whole sequence compared to a naturally occurring Klf polypeptide family member such as to those listed above or such as listed in Genbank accession number CAX16088 (mouse Klf4) or CAX14962 (human Klf4).", "Klf polypeptides (e.g., Klf1, Klf4, and Klf5) can be from human, mouse, rat, bovine, porcine, or other animals.", "Generally, the same species of protein will be used with the species of cells being manipulated.", "To the extent a Klf polypeptide is described herein, it can be replaced with an estrogen-related receptor beta (Essrb) polypeptide.", "Thus, it is intended that for each Klf polypeptide embodiment described herein, a corresponding embodiment using Essrb in the place of a Klf4 polypeptide is equally described.", "A “Myc polypeptide” refers any of the naturally-occurring members of the Myc family (see, e.g., Adhikary, S. & Eilers, M. Nat.", "Rev.", "Mol.", "Cell Biol.", "6:635-645 (2005)), or variants thereof that maintain transcription factor activity similar (within at least 50%, 80%, or 90% activity) compared to the closest related naturally occurring family member, or polypeptides comprising at least the DNA-binding domain of the naturally occurring family member, and can further comprise a transcriptional activation domain.", "Exemplary Myc polypeptides include, e.g., c-Myc, N-Myc and L-Myc.", "In some embodiments, variants have at least 85%, 90%, or 95% amino acid sequence identity across their whole sequence compared to a naturally occurring Myc polypeptide family member, such as to those listed above or such as listed in Genbank accession number CAA25015 (human Myc).", "Myc polypeptides (e.g., c-Myc) can be from human, mouse, rat, bovine, porcine, or other animals.", "Generally, the same species of protein will be used with the species of cells being manipulated.", "A “Sox polypeptide” refers to any of the naturally-occurring members of the SRY-related HMG-box (Sox) transcription factors, characterized by the presence of the high-mobility group (HMG) domain, or variants thereof that maintain transcription factor activity similar (within at least 50%, 80%, or 90% activity) compared to the closest related naturally occurring family member, or polypeptides comprising at least the DNA-binding domain of the naturally occurring family member, and can further comprise a transcriptional activation domain.", "See, e.g., Dang, D. T., et al., Int.", "J. Biochem.", "Cell Biol.", "32:1103-1121 (2000).", "Exemplary Sox polypeptides include, e.g., Sox1, Sox-2, Sox3, Sox4, Sox5, Sox6, Sox7, Sox8, Sox9, Sox10, Sox11, Sox12, Sox13, Sox14, Sox15, Sox17, Sox18, Sox-21, and Sox30.Sox1 has been shown to yield iPS cells with a similar efficiency as Sox2, and genes Sox3, Sox15, and Sox18 have also been shown to generate iPS cells, although with somewhat less efficiency than Sox2.See, Nakagawa, et al., Nature Biotechnology 26:101-106 (2007).", "In some embodiments, variants have at least 85%, 90%, or 95% amino acid sequence identity across their whole sequence compared to a naturally occurring Sox polypeptide family member such as to those listed above or such as listed in Genbank accession number CAA83435 (human Sox2).", "Sox polypeptides (e.g., Sox1, Sox2, Sox3, Sox15, or Sox18) can be from human, mouse, rat, bovine, porcine, or other animals.", "Generally, the same species of protein will be used with the species of cells being manipulated.", "“H3K9” refers to histone H3 lysine 9.H3K9 modifications associated with gene activity include H3K9 acetylation and H3K9 modifications associated with heterochromatin, include H3K9 di-methylation or tri-methylation.", "See, e.g., Kubicek, et al., Mol.", "Cell 473-481 (2007).", "The term “pluripotent” or “pluripotency” refers to cells with the ability to give rise to progeny cells that can undergo differentiation, under the appropriate conditions, into cell types that collectively demonstrate characteristics associated with cell lineages from all of the three germinal layers (endoderm, mesoderm, and ectoderm).", "Pluripotent stem cells can contribute to all embryonic derived tissues of a prenatal, postnatal or adult animal.", "A standard art-accepted test, such as the ability to form a teratoma in 8-12 week old SCID mice, can be used to establish the pluripotency of a cell population, however identification of various pluripotent stem cell characteristics can also be used to detect pluripotent cells.", "“Pluripotent stem cell characteristics” refer to characteristics of a cell that distinguish pluripotent stem cells from other cells.", "The ability to give rise to progeny that can undergo differentiation, under the appropriate conditions, into cell types that collectively demonstrate characteristics associated with cell lineages from all of the three germinal layers (endoderm, mesoderm, and ectoderm) is a pluripotent stem cell characteristic.", "Expression or non-expression of certain combinations of molecular markers are also pluripotent stem cell characteristics.", "For example, human pluripotent stem cells express at least some, and in some embodiments, all of the markers from the following non-limiting list: SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, TRA-2-49/6E, ALP, Sox2, E-cadherin, UTF-1, Oct4, Rex1, and Nanog.", "Cell morphologies associated with pluripotent stem cells are also pluripotent stem cell characteristics.", "As used herein, “non-pluripotent cells” refer to mammalian cells that are not pluripotent cells.", "Examples of such cells include differentiated cells as well as progenitor cells.", "Examples of differentiated cells include, but are not limited to, cells from a tissue selected from bone marrow, skin, skeletal muscle, fat tissue and peripheral blood.", "Exemplary cell types include, but are not limited to, fibroblasts, hepatocytes, myoblasts, neurons, osteoblasts, osteoclasts, and T-cells.", "In some embodiments where an individual is to be treated with the resulting pluripotent cells, the individual's own non-pluripotent cells are used to generate pluripotent cells according to the methods of the invention.", "Cells can be from, e.g., humans or non-human mammals.", "Exemplary non-human mammals include, but are not limited to, mice, rats, cats, dogs, rabbits, guinea pigs, hamsters, sheep, pigs, horses, bovines, and non-human primates (e.g., chimpanzees, macaques, and apes).", "A “recombinant” polynucleotide is a polynucleotide that is not in its native state, e.g., the polynucleotide comprises a nucleotide sequence not found in nature, or the polynucleotide is in a context other than that in which it is naturally found, e.g., separated from nucleotide sequences with which it typically is in proximity in nature, or adjacent (or contiguous with) nucleotide sequences with which it typically is not in proximity.", "For example, the sequence at issue can be cloned into a vector, or otherwise recombined with one or more additional nucleic acid.", "“Expression cassette” refers to a polynucleotide comprising a promoter or other regulatory sequence operably linked to a sequence encoding a protein.", "The terms “promoter” and “expression control sequence” are used herein to refer to an array of nucleic acid control sequences that direct transcription of a nucleic acid.", "As used herein, a promoter includes necessary nucleic acid sequences near the start site of transcription, such as, in the case of a polymerase II type promoter, a TATA element.", "A promoter also optionally includes distal enhancer or repressor elements, which can be located as much as several thousand base pairs from the start site of transcription.", "Promoters include constitutive and inducible promoters.", "A “constitutive” promoter is a promoter that is active under most environmental and developmental conditions.", "An “inducible” promoter is a promoter that is active under environmental or developmental regulation.", "The term “operably linked” refers to a functional linkage between a nucleic acid expression control sequence (such as a promoter, or array of transcription factor binding sites) and a second nucleic acid sequence, wherein the expression control sequence directs transcription of the nucleic acid corresponding to the second sequence.", "A “heterologous sequence” or a “heterologous nucleic acid”, as used herein, is one that originates from a source foreign to the particular host cell, or, if from the same source, is modified from its original form.", "Thus, a heterologous expression cassette in a cell is an expression cassette that is not endogenous to the particular host cell, for example by being linked to nucleotide sequences from an expression vector rather than chromosomal DNA, being linked to a heterologous promoter, being linked to a reporter gene, etc.", "The terms “nucleic acid” and “polynucleotide” are used interchangeably herein to refer to deoxyribonucleotides or ribonucleotides and polymers thereof in either single- or double-stranded form.", "The term encompasses nucleic acids containing known nucleotide analogs or modified backbone residues or linkages, which are synthetic, naturally occurring, and non-naturally occurring, which have similar binding properties as the reference nucleic acid, and which are metabolized in a manner similar to the reference nucleotides.", "Examples of such analogs include, without limitation, phosphorothioates, phosphoramidates, methyl phosphonates, chiral-methyl phosphonates, 2-O-methyl ribonucleotides, peptide-nucleic acids (PNAs).", "Unless otherwise indicated, a particular nucleic acid sequence also encompasses conservatively modified variants thereof (e.g., degenerate codon substitutions) and complementary sequences, as well as the sequence explicitly indicated.", "Specifically, degenerate codon substitutions may be achieved by generating sequences in which the third position of one or more selected (or all) codons is substituted with mixed-base and/or deoxyinosine residues (Batzer et al., Nucleic Acid Res.", "19:5081 (1991); Ohtsuka et al., J. Biol.", "Chem.", "260:2605-2608 (1985); Rossolini et al., Mol.", "Cell.", "Probes 8:91-98 (1994)).", "“Inhibitors,” “activators,” and “modulators” of expression or of activity are used to refer to inhibitory, activating, or modulating molecules, respectively, identified using in vitro and in vivo assays for expression or activity of a described target protein (or encoding polynucleotide), e.g., ligands, agonists, antagonists, and their homologs and mimetics.", "The term “modulator” includes inhibitors and activators.", "Inhibitors are agents that, e.g., inhibit expression or bind to, partially or totally block stimulation or protease inhibitor activity, reduce, decrease, prevent, delay activation, inactivate, desensitize, or down regulate the activity of the described target protein, e.g., antagonists.", "Activators are agents that, e.g., induce or activate the expression of a described target protein or bind to, stimulate, increase, open, activate, facilitate, enhance activation or protease inhibitor activity, sensitize or up regulate the activity of described target protein (or encoding polynucleotide), e.g., agonists.", "Modulators include naturally occurring and synthetic ligands, antagonists and agonists (e.g., small chemical molecules, antibodies and the like that function as either agonists or antagonists).", "Such assays for inhibitors and activators include, e.g., applying putative modulator compounds to cells expressing the described target protein and then determining the functional effects on the described target protein activity, as described above.", "Samples or assays comprising described target protein that are treated with a potential activator, inhibitor, or modulator are compared to control samples without the inhibitor, activator, or modulator to examine the extent of effect.", "Control samples (untreated with modulators) are assigned a relative activity value of 100%.", "Inhibition of a described target protein is achieved when the activity value relative to the control is about 80%, optionally 50% or 25, 10%, 5% or 1%.", "Activation of the described target protein is achieved when the activity value relative to the control is 110%, optionally 150%, optionally 200, 300%, 400%, 500%, or 1000-3000% or more higher.", "Where chemical substituent groups are specified by their conventional chemical formulae, written from left to right, they equally encompass the chemically identical substituents that would result from writing the structure from right to left, e.g., —CH2O— is equivalent to —OCH2—.", "The term “alkyl,” by itself or as part of another substituent, means, unless otherwise stated, a straight (i.e., unbranched) or branched chain, or combination thereof, which may be fully saturated, mono- or polyunsaturated and can include di- and multivalent radicals, having the number of carbon atoms designated (i.e., C1-C10 means one to ten carbons).", "Examples of saturated hydrocarbon radicals include, but are not limited to, groups such as methyl, ethyl, n-propyl, isopropyl, n-butyl, t-butyl, isobutyl, sec-butyl, cyclohexyl, (cyclohexyl)methyl, cyclopropylmethyl, homologs and isomers of, for example, n-pentyl, n-hexyl, n-heptyl, n-octyl, and the like.", "An unsaturated alkyl group is one having one or more double bonds or triple bonds.", "Examples of unsaturated alkyl groups include, but are not limited to, vinyl, 2-propenyl, crotyl, 2-isopentenyl, 2-(butadienyl), 2,4-pentadienyl, 3-(1,4-pentadienyl), ethynyl, 1- and 3-propynyl, 3-butynyl, and the higher homologs and isomers.", "The term “alkylene” by itself or as part of another substituent means a divalent radical derived from an alkyl, as exemplified, but not limited, by —CH2CH2CH2CH2—.", "Typically, an alkyl (or alkylene) group will have from 1 to 24 carbon atoms, with those groups having 10 or fewer carbon atoms being exemplified in the present invention.", "A “lower alkyl” or “lower alkylene” is a shorter chain alkyl or alkylene group, generally having eight or fewer carbon atoms.", "The term “heteroalkyl,” by itself or in combination with another term, means, unless otherwise stated, a stable straight or branched chain, or cyclic hydrocarbon radical, or combinations thereof, consisting of at least one carbon atoms and at least one heteroatom selected from the group consisting of O, N, P, Si and S, and wherein the nitrogen and sulfur atoms may optionally be oxidized and the nitrogen heteroatom may optionally be quaternized.", "The heteroatom(s) O, N, P and S and Si may be placed at any interior position of the heteroalkyl group or at the position at which the alkyl group is attached to the remainder of the molecule.", "Examples include, but are not limited to, —CH2—CH2—O—CH3, —CH2—CH2—NH—CH3, —CH2—CH2—N(CH3)—CH3, —CH2—S—CH2—CH3, —CH2—CH2, —S(O)—CH3, —CH2—CH2—S(O)2—CH3, —CH═CH—O—CH3, —Si(CH3)3, —CH2—CH═N—OCH3, —CH═CH—N(CH3)—CH3, O—CH3, —O—CH2—CH3, and —CN.", "Up to two heteroatoms may be consecutive, such as, for example, —CH2—NH—OCH3 and —CH2—O—Si(CH3)3.Similarly, the term “heteroalkylene” by itself or as part of another substituent means a divalent radical derived from heteroalkyl, as exemplified, but not limited by, —CH2—CH2—S—CH2—CH2— and —CH2—S—CH2—CH2—NH—CH2—.", "For heteroalkylene groups, heteroatoms can also occupy either or both of the chain termini (e.g., alkyleneoxy, alkylenedioxy, alkyleneamino, alkylenediamino, and the like).", "Still further, for alkylene and heteroalkylene linking groups, no orientation of the linking group is implied by the direction in which the formula of the linking group is written.", "For example, the formula —C(O)2R′— represents both —C(O)2R′— and —R′C(O)2—.", "As described above, heteroalkyl groups, as used herein, include those groups that are attached to the remainder of the molecule through a heteroatom, such as —C(O)R′, —C(O)NR′, —NR′R″, —OR′, —SR′, and/or —SO2R′.", "Where “heteroalkyl” is recited, followed by recitations of specific heteroalkyl groups, such as —NR′R″ or the like, it will be understood that the terms heteroalkyl and —NR′R″ are not redundant or mutually exclusive.", "Rather, the specific heteroalkyl groups are recited to add clarity.", "Thus, the term “heteroalkyl” should not be interpreted herein as excluding specific heteroalkyl groups, such as —NR′R″ or the like.", "The terms “cycloalkyl” and “heterocycloalkyl”, by themselves or in combination with other terms, represent, unless otherwise stated, cyclic versions of “alkyl” and “heteroalkyl”, respectively.", "Additionally, for heterocycloalkyl, a heteroatom can occupy the position at which the heterocycle is attached to the remainder of the molecule.", "Examples of cycloalkyl include, but are not limited to, cyclopentyl, cyclohexyl, 1-cyclohexenyl, 3-cyclohexenyl, cycloheptyl, and the like.", "Examples of heterocycloalkyl include, but are not limited to, 1-(1,2,5,6-tetrahydropyridyl), 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-morpholinyl, 3-morpholinyl, tetrahydrofuran-2-yl, tetrahydrofuran-3-yl, tetrahydrothien-2-yl, tetrahydrothien-3-yl, 1-piperazinyl, 2-piperazinyl, and the like.", "A “cycloalkylene” and “heterocycloalkylene” refer to a divalent radical derived from cycloalkyl and heterocycloalkyl, respectively.", "The terms “halo” or “halogen,” by themselves or as part of another substituent, mean, unless otherwise stated, a fluorine, chlorine, bromine, or iodine atom.", "Additionally, terms such as “haloalkyl,” are meant to include monohaloalkyl and polyhaloalkyl.", "For example, the term “halo(C1-C4)alkyl” is mean to include, but not be limited to, trifluoromethyl, 2,2,2-trifluoroethyl, 4-chlorobutyl, 3-bromopropyl, and the like.", "The term “aryl” means, unless otherwise stated, a polyunsaturated, aromatic, hydrocarbon substituent which can be a single ring or multiple rings (preferably from 1 to 3 rings) which are fused together or linked covalently.", "The term “heteroaryl” refers to aryl groups (or rings) that contain from one to four heteroatoms selected from N, O, and S, wherein the nitrogen and sulfur atoms are optionally oxidized, and the nitrogen atom(s) are optionally quaternized.", "A heteroaryl group can be attached to the remainder of the molecule through a carbon or heteroatom.", "Non-limiting examples of aryl and heteroaryl groups include phenyl, 1-naphthyl, 2-naphthyl, 4-biphenyl, 1-pyrrolyl, 2-pyrrolyl, 3-pyrrolyl, 3-pyrazolyl, 2-imidazolyl, 4-imidazolyl, pyrazinyl, 2-oxazolyl, 4-oxazolyl, 2-phenyl-4-oxazolyl, 5-oxazolyl, 3-isoxazolyl, 4-isoxazolyl, 5-isoxazolyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidyl, 4-pyrimidyl, 5-benzothiazolyl, purinyl, 2-benzimidazolyl, 5-indolyl, 1-isoquinolyl, 5-isoquinolyl, 2-quinoxalinyl, 5-quinoxalinyl, 3-quinolyl, and 6-quinolyl.", "Substituents for each of the above noted aryl and heteroaryl ring systems are selected from the group of acceptable substituents described below.", "“Arylene” and “heteroarylene” refers to a divalent radical derived from a aryl and heteroaryl, respectively.", "For brevity, the term “aryl” when used in combination with other terms (e.g., aryloxy, arylthioxy, arylalkyl) includes both aryl and heteroaryl rings as defined above.", "Thus, the term “arylalkyl” is meant to include those radicals in which an aryl group is attached to an alkyl group (e.g., benzyl, phenethyl, pyridylmethyl and the like) including those alkyl groups in which a carbon atom (e.g., a methylene group) has been replaced by, for example, an oxygen atom (e.g., phenoxymethyl, 2-pyridyloxymethyl, 3-(1-naphthyloxy)propyl, and the like).", "The term “oxo” as used herein means an oxygen that is double bonded to a carbon atom.", "The term “alkylsulfonyl” as used herein means a moiety having the formula —S(O2)-R′, where R′ is an alkyl group as defined above.", "R′ may have a specified number of carbons (e.g.", "“C1-C4 alkylsulfonyl”).", "Each of the above terms (e.g., “alkyl,” “heteroalkyl,” “aryl” and “heteroaryl”) are meant to include both substituted and unsubstituted forms of the indicated radical.", "Exemplary substituents for each type of radical are provided below.", "Substituents for the alkyl and heteroalkyl radicals (including those groups often referred to as alkylene, alkenyl, heteroalkylene, heteroalkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, and heterocycloalkenyl) can be one or more of a variety of groups selected from, but not limited to: —OR′, ═O, ═NR′, ═N—OR′, —NR′R″, —SR′, -halogen, —SiR′R″R′″, —OC(O)R, —C(O)W, —CO2R, —CONR′R″, —OC(O)NR′R″, —NR″C(O)R, —NR′—C(O)NR″R′″, —NR″C(O)2R′, —NR—C(NR′R″R′″)═NR″″, —NR—C(NR′R”)═NR′″, —S(O)R′, —S(O)2R′, —S(O)2NR′R″, —NRSO2R′, —CN and —NO2 in a number ranging from zero to (2m′+1), where m′ is the total number of carbon atoms in such radical.", "R′, R″, R′″ and R″″ each preferably independently refer to hydrogen, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl (e.g., aryl substituted with 1-3 halogens), substituted or unsubstituted alkyl, alkoxy or thioalkoxy groups, or arylalkyl groups.", "When a compound of the invention includes more than one R group, for example, each of the R groups is independently selected as are each R′, R″, R′″ and R″″ groups when more than one of these groups is present.", "When R′ and R″ are attached to the same nitrogen atom, they can be combined with the nitrogen atom to form a 4-, 5-, 6-, or 7-membered ring.", "For example, —NR′R″ is meant to include, but not be limited to, 1-pyrrolidinyl and 4-morpholinyl.", "From the above discussion of substituents, one of skill in the art will understand that the term “alkyl” is meant to include groups including carbon atoms bound to groups other than hydrogen groups, such as haloalkyl (e.g., —CF3 and —CH2CF3) and acyl (e.g., —C(O)CH3, —C(O)CF3, —C(O)CH2OCH3, and the like).", "Similar to the substituents described for the alkyl radical, substituents for the aryl and heteroaryl groups are varied and are selected from, for example: halogen, —OR′, —NR′R″, —SR′, -halogen, —SiR′R″R′″, —OC(O)R, —C(O)R′, —CO2R, —CONR′R″, —OC(O)NR′R″, —NR″C(O)R′, —NR′—C(O)NR″R′″, —NR″C(O)2R′, —NR—C(NR′R″R′″)═NR″″, —NR—C(NR′R″)═NR′″, —S(O)R′, —S(O)2R′, —S(O)2NR′R″, —NRSO2R′, —CN and —NO2, —R′, —N3, —CH(Ph)2, fluoro(C1-C4)alkoxy, and fluoro(C1-C4)alkyl, in a number ranging from zero to the total number of open valences on the aromatic ring system; and where R′, R″, R′″ and R″″ are preferably independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl.", "When a compound of the invention includes more than one R group, for example, each of the R groups is independently selected as are each R′, R″, R′″ and R″″ groups when more than one of these groups is present.", "Two of the substituents on adjacent atoms of the aryl or heteroaryl ring may optionally form a ring of the formula -T-C(O)—(CRR′)q—U—, wherein T and U are independently —NR—, —O—, —CRR′— or a single bond, and q is an integer of from 0 to 3.Alternatively, two of the substituents on adjacent atoms of the aryl or heteroaryl ring may optionally be replaced with a substituent of the formula -A-(CH2)r—B—, wherein A and B are independently —CRR′—, —O—, —NR—, —S—, —S(O)—, —S(O)2—, —S(O)2NR′— or a single bond, and r is an integer of from 1 to 4.One of the single bonds of the new ring so formed may optionally be replaced with a double bond.", "Alternatively, two of the substituents on adjacent atoms of the aryl or heteroaryl ring may optionally be replaced with a substituent of the formula —(CRR′)s—X1—(C″R′″)d—, where s and d are independently integers of from 0 to 3, and X′ is —O—, —NR′—, —S—, —S(O)—, —S(O)2—, or —S(O)2NR′—.", "The substituents R, R′, R″ and R′″ are preferably independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl.", "As used herein, the term “heteroatom” or “ring heteroatom” is meant to include oxygen (O), nitrogen (N), sulfur (S), phosphorus (P), and silicon (Si).", "A “substituent group,” as used herein, means a group selected from the following moieties: (A) —OH, —NH2, —SH, —CN, —CF3, —NO2, oxo, halogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, unsubstituted heteroaryl, and (B) alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, substituted with at least one substituent selected from: (i) oxo, —OH, —NH2, —SH, —CN, —CF3, —NO2, halogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, unsubstituted heteroaryl, and (ii) alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, substituted with at least one substituent selected from: (a) oxo, —OH, —NH2, —SH, —CN, —CF3, —NO2, halogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, unsubstituted heteroaryl, and (b) alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, substituted with at least one substituent selected from oxo, —OH, —NH2, —SH, —CN, —CF3, —NO2, halogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, and unsubstituted heteroaryl.", "A “size-limited substituent” or “size-limited substituent group,” as used herein means a group selected from all of the substituents described above for a “substituent group,” wherein each substituted or unsubstituted alkyl is a substituted or unsubstituted C1-C20 alkyl, each substituted or unsubstituted heteroalkyl is a substituted or unsubstituted 2 to 20 membered heteroalkyl, each substituted or unsubstituted cycloalkyl is a substituted or unsubstituted C4-C8 cycloalkyl, and each substituted or unsubstituted heterocycloalkyl is a substituted or unsubstituted 4 to 8 membered heterocycloalkyl.", "A “lower substituent” or “lower substituent group,” as used herein means a group selected from all of the substituents described above for a “substituent group,” wherein each substituted or unsubstituted alkyl is a substituted or unsubstituted C1-C8 alkyl, each substituted or unsubstituted heteroalkyl is a substituted or unsubstituted 2 to 8 membered heteroalkyl, each substituted or unsubstituted cycloalkyl is a substituted or unsubstituted C5-C7 cycloalkyl, and each substituted or unsubstituted heterocycloalkyl is a substituted or unsubstituted 5 to 7 membered heterocycloalkyl.", "The term “pharmaceutically acceptable salts” is meant to include salts of the active compounds which are prepared with relatively nontoxic acids or bases, depending on the particular substituents found on the compounds described herein.", "When compounds of the present invention contain relatively acidic functionalities, base addition salts can be obtained by contacting the neutral form of such compounds with a sufficient amount of the desired base, either neat or in a suitable inert solvent.", "Examples of pharmaceutically acceptable base addition salts include sodium, potassium, calcium, ammonium, organic amino, or magnesium salt, or a similar salt.", "When compounds of the present invention contain relatively basic functionalities, acid addition salts can be obtained by contacting the neutral form of such compounds with a sufficient amount of the desired acid, either neat or in a suitable inert solvent.", "Examples of pharmaceutically acceptable acid addition salts include those derived from inorganic acids like hydrochloric, hydrobromic, nitric, carbonic, monohydrogencarbonic, phosphoric, monohydrogenphosphoric, dihydrogenphosphoric, sulfuric, monohydrogensulfuric, hydriodic, or phosphorous acids and the like, as well as the salts derived from relatively nontoxic organic acids like acetic, propionic, isobutyric, maleic, malonic, benzoic, succinic, suberic, fumaric, lactic, mandelic, phthalic, benzenesulfonic, p-tolylsulfonic, citric, tartaric, methanesulfonic, and the like.", "Also included are salts of amino acids such as arginate and the like, and salts of organic acids like glucuronic or galactunoric acids and the like (see, for example, Berge et al., “Pharmaceutical Salts”, Journal of Pharmaceutical Science, 1977, 66, 1-19).", "Certain specific compounds of the present invention contain both basic and acidic functionalities that allow the compounds to be converted into either base or acid addition salts.", "Thus, the compounds of the present invention may exist as salts with pharmaceutically acceptable acids.", "The present invention includes such salts.", "Examples of such salts include hydrochlorides, hydrobromides, sulfates, methanesulfonates, nitrates, maleates, acetates, citrates, fumarates, tartrates (eg (+)-tartrates, (−)-tartrates or mixtures thereof including racemic mixtures, succinates, benzoates and salts with amino acids such as glutamic acid.", "These salts may be prepared by methods known to those skilled in the art.", "The neutral forms of the compounds are preferably regenerated by contacting the salt with a base or acid and isolating the parent compound in the conventional manner.", "The parent form of the compound differs from the various salt forms in certain physical properties, such as solubility in polar solvents.", "In addition to salt forms, the present invention provides compounds, which are in a prodrug form.", "Prodrugs of the compounds described herein are those compounds that readily undergo chemical changes under physiological conditions to provide the compounds of the present invention.", "Additionally, prodrugs can be converted to the compounds of the present invention by chemical or biochemical methods in an ex vivo environment.", "For example, prodrugs can be slowly converted to the compounds of the present invention when placed in a transdermal patch reservoir with a suitable enzyme or chemical reagent.", "Certain compounds of the present invention can exist in unsolvated forms as well as solvated forms, including hydrated forms.", "In general, the solvated forms are equivalent to unsolvated forms and are encompassed within the scope of the present invention.", "Certain compounds of the present invention may exist in multiple crystalline or amorphous forms.", "In general, all physical forms are equivalent for the uses contemplated by the present invention and are intended to be within the scope of the present invention.", "Certain compounds of the present invention possess asymmetric carbon atoms (optical centers) or double bonds; the racemates, diastereomers, tautomers, geometric isomers and individual isomers are encompassed within the scope of the present invention.", "The compounds of the present invention do not include those which are known in the art to be too unstable to synthesize and/or isolate.", "The compounds of the present invention may also contain unnatural proportions of atomic isotopes at one or more of the atoms that constitute such compounds.", "For example, the compounds may be radiolabeled with radioactive isotopes, such as for example tritium (3H), iodine-125 (125I) or carbon-14 (14C).", "All isotopic variations of the compounds of the present invention, whether radioactive or not, are encompassed within the scope of the present invention.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1A-1E.", "Compound treatment for seven days is sufficient to induce pluripotent stem cells from human fibroblasts transduced with the four reprogramming factors.", "(FIG.", "1A) Timeline for human iPSC induction using combined SB431542 and PD0325901 treatment along with 4TFs.", "Treatment began with cell re-seeding at day 7 after 4TF transduction and was maintained for 7 days.", "(FIG.", "1B) Staining for ALP+ colonies that emerged in the untreated (left) or 2 compound-treated (right) cultures within seven days.", "(FIG.", "1C) RT-PCR showing elevated endogenous mRNA expression of pluripotency markers OCT4 and NANOG in 2 compound-treated cultures.", "(FIG.", "1D) TRA-1-81 staining at day 14 without (left) or with (right) 2 compound treatment.", "(FIG.", "1E) The numbers of NANOG+ colonies at day 14 under different treatment conditions are plotted.", "(FIG.", "1F) Typical staining for hESC-specific markers (NANOG and SSEA4) exhibited by D14 iPSCs.", "Scale bars, 50 μm in (d & f).", "FIG.", "2A-2F.", "Prolonged compound treatment and cell passaging dramatically increased the number of reprogrammed colonies.", "(FIG.", "2A) Timeline of human iPSC induction using SB431542, PD0325901 and thiazovivin.", "(FIG.", "2B) Day 30 iPSCs expressed pluripotency markers NANOG, SSEA4 and TRA-1-81.Scale bars, 50 μm (FIG.", "2C) ALP staining of day 30 cultures with (upper panels) or without (lower panels) 3 compound treatment.", "Boxed areas in the left panels are enlarged in the right panels.", "Scale bars, 200 μm (FIG.", "2D) Number of NANOG+ colonies on day 30 under different treatment conditions, without splitting.", "(FIG.", "2E) Number of NANOG+ colonies on day 30 from 3 compound-treated cultures trypsinized as indicated.", "(FIG.", "2F) RT-PCR on iPSC colonies obtained with 3 compound treatment shows reactivated expression of endogenous pluripotency markers.", "HDF: Human Dermal Fibroblast.", "FIG.", "3A-3C.", "In vitro and in vivo differentiation of iPSCs generated with 3 compound treatment.", "(FIG.", "3A) Micrographs show embryoid bodies (EB) generated from iPSCs and in vitro differentiation into ectodermal TUBULIN), mesodermal (BRACHYURY) and endodermal (PDX1) cell types.", "Scale bars, EB: 100 μm; others 10 μm (FIG.", "3B) RT-PCR showing expression of representative lineage markers and the absence of OCT4 mRNA expression in differentiating cells.", "U—undifferentiated, D—differentiated.", "(FIG.", "3C) Teratomas generated in nude mice from iPSCs (3 independent colonies tested) consist of tissues from all three germ layers.", "Left panel: 1—muscle, 2—neural epithelium; middle panel: 1—skin, 2—gut epithelium; right panel: 1—bone, 2—cartilage.", "Scale bars, 20 μm.", "FIG.", "4A-4C.", "Compound treatment enhanced iPS cell generation in a dose dependent manner.", "FIG.", "5.Stably expanded iPS cell colonies generated through compound treatment exhibited normal karyotype.", "FIG.", "6A-6F.", "Transgene expression and silencing are independent of compound treatment.", "(FIG.", "6A) The reprogramming effect of the SB431542 and PD0325901 combination was tested on BJ cells transduced with lentiviral vectors (pSin) carrying the four factors (OCT4, NANOG, SOX2, and LIN28).", "On day 30 the compound-treated cultures showed a substantially increased number of ALP+ hESC-like colonies when compared to 4TFs control.", "(FIG.", "6B) BJ cells were transduced with retrovirus carrying a YFP expression vector and were cultured either in the presence or absence of SB431542, PD0325901, and Thiazovivin.", "(FIG.", "6C-6F) Cells were subjected to (FIG.", "6C) FACS analysis on day 10 and day 38 or (FIG.", "6D-6F) fluorescence microscopy on day 3 (FIG.", "6D), day 10 (FIG.", "6E), and day 28 (FIG.", "6F).", "FIG.", "7.Chemical structure of Thiazovivin.", "FIG.", "8A-8E.", "Generation of human induced pluripotent stem cells from primary keratinocytes by single gene, OCT4, and small molecules.", "(FIG.", "8A) Treatment with 0.5 μM PD0325901 (PD) and 0.5 μM A-83-01 (A83) significantly improved generation of iPSCs from primary human keratinocytes transduced with either 4TFs (4F, OKSM) or 3TFs (3F, OKS).", "NHEKs were seeded at a density of 100,000 transduced cells per 10 cm dish.", "(FIG.", "8B) Further chemical screens identified PS48, NaB, and their combination that can substantially enhance reprogramming of primary human keratinocytes transduced with 2TFs (OK).", "NHEKs were seeded at a density of 100,000 transduced cells per 10 cm dish.", "(FIG.", "8C) Experimental scheme for generation of human iPSCs from primary human keratinocytes transduced by a single reprogramming gene, OCT4.KCM, keratinocyte culture medium; hESCM, human ESC culture media.", "(FIG.", "8D) Live immunostaining with TRA-1-81 of iPSC colonies that were generated from primary human keratinocytes transduced with 2TFs/OK or 1TF/OCT4 before picking-up of colonies.", "(FIG.", "8E) The established human iPSC-OK and iPSC-O cells express typical pluripotency markers, including ALP (alkaline phosphatase), OCT4, SOX2, NANOG, SSEA-4 and TRA-1-81.Nuclei were stained with DAPI.", "FIG.", "9A-9F.", "In depth characterizations of human iPSC-OK and iPSC-O cells.", "(FIG.", "9A) Expression analysis by RT-PCR of the endogenous pluripotency genes and exogenous OCT4 and KLF4.GAPDH was used as an input control.", "(FIG.", "9B) Methylation analysis of the OCT4 and NANOG promoters by bisulfate genomic sequencing.", "Open circles and closed circles indicate unmethylated and methylated CpGs in the promoter regions, respectively.", "(FIG.", "9C) Scatter plots comparing global gene expression patterns between iPSC-O cells and NHEKs, and hESCs.", "The positions of the pluripotency genes OCT4, NANOG, and SOX2 are shown by arrows.", "Black lines indicate the linear equivalent and twofold changes in gene expression levels between the samples.", "(FIG.", "9D) Human iPSC-OK and iPSC-O could effectively differentiate in vitro into cells in the three germ layers, including neural ectodermal cells tubulin), mesodermal cells (SMA), and endodermal cells (AFP) using EB method.", "(FIG.", "9E) Quantitative PCR test of three germ layer markers from differentiated human iPSCs using EB method: ectoderm (PAX6, βIII TUBULIN), mesoderm (FOXF1, HAND1) and endoderm (AFP, GATA6).", "Data denotes GAPDH-normalized fold changes relative to undifferentiated parental human iPSCs.", "(FIG.", "9F) Human iPSC-OK and iPSC-O could effectively produce full teratoma, which contains differentiated cells in the three germ layers, in SCID mice.", "FIG.", "10A-10F.", "Generation and characterizations of human induced pluripotent stem cells from human umbilical vein endothelial cells by single gene, OCT4, and small molecules.", "(FIG.", "10A) Experimental scheme for generation of human iPSCs from HUVECs transduced by OCT4.HCM, HUVEC culture medium; hESCM, human ESC culture media.", "(FIG.", "10B) The established hiPSC-O cells from HUVECs express typical pluripotency markers, including NANOG and SSEA-4.Nuclei were stained with DAPI.", "(FIG.", "10C) Expression analysis by RT-PCR of the endogenous pluripotency genes.", "GAPDH was used as an input control.", "(FIG.", "10D) Methylation analysis of the OCT4 and NANOG promoters by bisulfate genomic sequencing.", "Open circles and closed circles indicate unmethylated and methylated CpGs in the promoter regions, respectively.", "(FIG.", "10E) hiPSC-O cells from HUVECs could effectively differentiate in vitro into cells in the three germ layers, including neural ectodermal cells tubulin), mesodermal cells (SMA), and endodermal cells (AFP) using EB method.", "(FIG.", "10F) hiPSC-O cells could effectively produce full teratoma, which contains differentiated cells in the three germ layers in SCID mice.", "FIG.", "11A-11B.", "Characterization of human iPSC-O cells from AHEKs.", "(FIG.", "11A) The established hiPSC-O cells from adult keratinocytes express typical pluripotency markers, including NANOG, SOX2 and SSEA-4.Nuclei were stained with DAPI.", "(FIG.", "11B) These hiPSC-O cells could effectively differentiate in vitro into cells in the three germ layers, including neural ectodermal cells tubulin), mesodermal cells (SMA), and endodermal cells (AFP) using EB method.", "FIG.", "12A-12B.", "Characterization of human iPSC-O cells from AFDCs.", "(FIG.", "12A) The established hiPSC-O cells from amniotic fluid derived cells express typical pluripotency markers, including NANOG, SOX2 and SSEA-4.Nuclei were stained with DAPI.", "(FIG.", "12B) These hiPSC-O cells could effectively differentiate in vitro into cells in the three germ layers, including neural ectodermal cells tubulin), mesodermal cells (SMA), and endodermal cells (AFP) using EB method.", "FIG.", "13.Additional hiPSC cell lines express typical pluripotency markers.", "The other established hiPSC-O cell lines express typical pluripotency markers, including NANOG and SSEA-4.Nuclei were stained with DAPI.", "FIG.", "14.Feeder free culture of hiPSC cell lines.", "hiPSCs were split onto Matrigel/ECM-coated plates in chemically defined hESC medium as previously reported.", "These hiPSCs could be maintained and expanded in a feeder-free environment.", "ICC showed the expression of pluripiotency markers, OCT4 and SSEA4.Nuclei were stained with DAPI.", "FIG.", "15A-15B.", "Genotyping of hiPSCs.", "RT-PCR analysis using genomic DNA shows that only OCT4 transgene integrated in the genome of hiPSC-O lines (hiPSC-O#1, hiPSC-O#3, hiPSC-O#21, hiPSC-O#26 and hiPSC-O#31).", "NHEKs (FIG.", "15A) and HUVECs (FIG.", "15B) used as negative controls, while vectors used as positive controls.", "FIG.", "16.Integration of the OCT4 transgene in hiPSCs.", "Genomic DNA (10 μg) were digested with EcoRI and hybridized with the OCT4 cDNA probe (an EcoRI/SpeI fragment of pSin-EF2-OCT4-Pur).", "Multiple transgenic integrations were detected.", "FIG.", "17A-17B.", "Karyotyping for hiPSC cell lines.", "Metaphase spread of hiPSC-O#1 (FIG.", "17A) and hiPSC-O#21 (FIG.", "17B) show normal karyotype after passage 15.DETAILED DESCRIPTION I.", "Introduction The present invention is based on the surprising discovery that a combination of an ALK5 inhibitor, a MEK inhibitor, and a ROCK inhibitor greatly improves efficiency of induction of pluripotency in non-pluripotent mammalian cells transformed with four transcription factors.", "Accordingly, the present invention provides for methods of inducing pluripotency in non-pluripotent mammalian cells wherein the method comprises contacting the non-pluripotent cells with at least a TGFβ receptor/ALK5 inhibitor, preferably in combination with a MEK/ERK pathway inhibitor, and in particular embodiments, a Rho GTPase/ROCK inhibitor.", "II.", "TGFβ Receptor/ALK5 Inhibitors Activin receptor-like kinase 5 (ALK-5) is the principal TGFβ receptor that mediates cellular responses to TGF-βs (Massague J. Annu Rev Biochem 67:753-791 (1998); Massague J, Chen YG.", "Genes Dev 14:627-644 (2000); Franzen P, et al.", "Cell 75:681-692 (1993)).", "Upon ligand binding, constitutively active TORII kinase phosphorylates ALK-5 which, in turn, activates the downstream signal transduction cascades.", "ALK-5-activated Smad2 and Smad3 phosphorylation is the most prominent pathway (Massague J, Chen YG.", "Genes Dev 14:627-644 (2000)).", "Once activated, Smad2/3 associates with Smad4 and translocates to the nucleus, where the complex transcriptionally regulates target gene expression.", "TGFβ receptor (i.e.", "ALK5) inhibitors can include antibodies to, dominant negative variants of, and siRNA, microRNA, antisense nucleic acids, and other polynucleotides that suppress expression of, TGFβ receptors (e.g., ALK5).", "Exemplary TGFβ receptor/ALK5 inhibitors include, but are not limited to, SB431542 (see, e.g., Inman, et al., Molecular Pharmacology 62(1):65-74 (2002)), A-83-01, also known as 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-p yrazole-1-carbothioamide (see, e.g., Tojo, et al., Cancer Science 96(11):791-800 (2005), and commercially available from, e.g., Toicris Bioscience); 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine, Wnt3a/BIO (see, e.g., Dalton, et al., WO2008/094597, herein incorporated by reference), BMP4 (see, Dalton, supra), GW788388 (-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamide) (see, e.g., Gellibert, et al., Journal of Medicinal Chemistry 49(7):2210-2221 (2006)), SM16 (see, e.g., Suzuki, et al., Cancer Research 67(5):2351-2359 (2007)), IN-1130 (3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzamide) (see, e.g., Kim, et al., Xenobiotica 38(3):325-339 (2008)), GW6604 (2-phenyl-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine) (see, e.g., de Gouville, et al., Drug News Perspective 19(2):85-90 (2006)), SB-505124 (2-(5-benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride) (see, e.g., DaCosta, et al., Molecular Pharmacology 65(3):744-752 (2004)) and pyrimidine derivatives (see, e.g., those listed in Stiefl, et al., WO2008/006583, herein incorporated by reference).", "Further, while “an ALK5 inhibitor” is not intended to encompass non-specific kinase inhibitors, an “ALK5 inhibitor” should be understood to encompass inhibitors that inhibit ALK4 and/or ALK7 in addition to ALK5, such as, for example, SB-431542 (see, e.g., Inman, et al., J, Mol.", "Phamacol.", "62(1): 65-74 (2002).", "In view of the data herein showing the effect of inhibiting ALK5, it is believed that inhibition of the TGFβ/activin pathway will have similar effects.", "Thus, any inhibitor (e.g., upstream or downstream) of the TGFβ/activin pathway can be used in combination with, or instead of, ALK5 inhibitors as described in each paragraph herein.", "Exemplary TGFβ/activin pathway inhibitors include but are not limited to: TGFβ receptor inhibitors, inhibitors of SMAD 2/3 phosphorylation, inhibitors of the interaction of SMAD 2/3 and SMAD 4, and activators/agonists of SMAD 6 and SMAD 7.Furthermore, the categorizations described below are merely for organizational purposes and one of skill in the art would know that compounds can affect one or more points within a pathway, and thus compounds may function in more than one of the defined categories.", "TGFβ receptor inhibitors can include antibodies to, dominant negative variants of and siRNA or antisense nucleic acids that target TGFβ receptors.", "Specific examples of inhibitors include but are not limited to SU5416; 2-(5-benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride (SB-505124); lerdelimumb (CAT-152); metelimumab (CAT-192); GC-1008; ID11; AP-12009; AP-11014; LY550410; LY580276; LY364947; LY2109761; SB-505124; SB-431542; SD-208; SM16; NPC-30345; Ki26894; SB-203580; SD-093; Gleevec; 3,5,7,2′,4′-pentahydroxyflavone (Morin); activin-M108A; P144; soluble TBR2-Fc; and antisense transfected tumor cells that target TGFβ receptors.", "(See, e.g., Wrzesinski, et al., Clinical Cancer Research 13(18):5262-5270 (2007); Kaminska, et al., Acta Biochimica Polonica 52(2):329-337 (2005); and Chang, et al., Frontiers in Bioscience 12:4393-4401 (2007).", "In addition, the inventors have found that the TGFβ inhibitors BMP-4 and BMP-7 have similar cellular reprogramming effects as the ALK5 inhibitor described in the examples, thereby providing further evidence that TGFβ inhibitors can be used for reprogramming (e.g., in combination with a MEK/ERK pathway inhibitor and a Rho GTPase/ROCK inhibitor).", "Exemplary human BMP-4 and BMP-7 protein sequences are set forth in, for example, U.S. Pat.", "No.", "7,405,192.Inhibitors of SMAD 2/3 phosphorylation can include antibodies to, dominant negative variants of and antisense nucleic acids that target SMAD2 or SMAD3.Specific examples of inhibitors include PD169316; SB203580; SB-431542; LY364947; A77-01; and 3,5,7,2′,4′-pentahydroxyflavone (Morin).", "(See, e.g., Wrzesinski, supra; Kaminska, supra; Shimanuki, et al., Oncogene 26:3311-3320 (2007); and Kataoka, et al., EP1992360, incorporated herein by reference.)", "Inhibitors of the interaction of SMAD 2/3 and smad4 can include antibodies to, dominant negative variants of and antisense nucleic acids that target SMAD2, SMAD3 and/or smad4.Specific examples of inhibitors of the interaction of SMAD 2/3 and SMAD4 include but are not limited to Trx-SARA, Trx-xFoxH1b and Trx-Lef1.", "(See, e.g., Cui, et al., Oncogene 24:3864-3874 (2005) and Zhao, et al., Molecular Biology of the Cell, 17:3819-3831 (2006).)", "Activators/agonists of SMAD 6 and SMAD 7 include but are not limited to antibodies to, dominant negative variants of and antisense nucleic acids that target SMAD 6 or SMAD 7.Specific examples of inhibitors include but are not limited to smad7-as PTO-oligonucleotides.", "See, e.g., Miyazono, et al., U.S. Pat.", "No.", "6,534,476, and Steinbrecher, et al., US2005119203, both incorporated herein by reference.", "Those of skill will appreciate that the concentration of the TGFβ receptor/ALK5 inhibitor will depend on which specific inhibitor is used.", "Generally, the concentration of a TGFβ receptor/ALK5 inhibitor in a cell culture will be in the range of IC20-IC100 (i.e., concentrations in which 20% inhibition to 100% inhibition in cells is achieved.", "For example, SB432542 would be used at 0.5-10 μM, optimally around 1-5 μM.", "In certain embodiments, a combination of two or more different TGFβ receptor/ALK5 inhibitors can be used.", "III.", "MEK/ERK Pathway Inhibitors The MEK/ERK pathway refers to the MEK and ERK serine/threonine kinases that make up part of a signal transduction pathway.", "Generally, activated Ras activates the protein kinase activity of RAF kinase.", "RAF kinase phosphorylates and activates MEK, which in turn phosphorylates and activates a mitogen-activated protein kinase (MAPK).", "MAPK was originally called “extracellular signal-regulated kinases” (ERKs) and microtubule-associated protein kinase (MAPK).", "Thus, “ERK” and “MAPK” are used synonymously.", "MEK/ERK pathway inhibitors refer to inhibitors of either MEK or ERK that are part of the Raf/MEK/ERK pathway.", "Because the inventors have found that MEK inhibitors are effective in improving induction of iPSCs, and because MEK directly controls ERK activity, it is believed that MEK inhibitors as described for the present invention, can be replaced with an ERK inhibitor as desired.", "Inhibitors of MEK (i.e., MEK1 (also known as mitogen-activated protein kinase kinase 1) and/or MEK2 (also known as mitogen-activated protein kinase kinase 2)) can include antibodies to, dominant negative variants of, and siRNA and siRNA, microRNA, antisense nucleic acids, and other polynucleotides that suppress expression of, MEK.", "Specific examples of MEK inhibitors include, but are not limited to, PD0325901, (see, e.g., Rinehart, et al., Journal of Clinical Oncology 22: 4456-4462 (2004)), PD98059 (available, e.g., from Cell Signaling Technology), U0126 (available, for example, from Cell Signaling Technology), SL 327 (available, e.g., from Sigma-Aldrich), ARRY-162 (available, e.g., from Array Biopharma), PD184161 (see, e.g., Klein, et al., Neoplasia 8:1-8 (2006)), PD184352 (CI-1040) (see, e.g., Mattingly, et al., The Journal of Pharmacology and Experimental Therapeutics 316:456-465 (2006)), sunitinib (see, e.g., Voss, et al., US2008004287 incorporated herein by reference), sorafenib (see, Voss supra), Vandetanib (see, Voss supra), pazopanib (see, e.g., Voss supra), Axitinib (see, Voss supra) and PTK787 (see, Voss supra).", "Currently, several MEK inhibitors are undergoing clinical trial evaluations.", "CI-1040 has been evaluate in Phase I and II clinical trials for cancer (see, e.g., Rinehart, et al., Journal of Clinical Oncology 22(22):4456-4462 (2004)).", "Other MEK inhibitors being evaluated in clinical trials include PD184352 (see, e.g., English, et al., Trends in Pharmaceutical Sciences 23(1):40-45 (2002)), BAY 43-9006 (see, e.g., Chow, et al., Cytometry (Communications in Clinical Cytometry) 46:72-78 (2001)), PD-325901 (also PD0325901), GSK1120212, ARRY-438162, RDEA119, AZD6244 (also ARRY-142886 or ARRY-886), RO5126766, XL518 and AZD8330 (also ARRY-704).", "(See, e.g., information from the National Institutes of Health located on the World Wide Web at clinicaltrials.gov as well as information from the Nation Cancer Institute located on the World Wide Web at cancer.gov/clinicaltrials.", "Exemplary ERK (i.e., ERK1 (also known as MAPK3) and/or ERK2 (also known as MAPK1)) inhibitors include PD98059 (see, e.g., Zhu, et al., Oncogene 23:4984-4992 (2004)), U0126 (see, Zhu, supra), FR180204 (see, e.g., Ohori, Drug News Perspective 21(5):245-250 (2008)), sunitinib (see, e.g., US2008004287 incorporated herein by reference), sorafenib, Vandetanib, pazopanib, Axitinib and PTK787.Those of skill will appreciate that the concentration of the MEK/ERK pathway inhibitor will depend on which specific inhibitor is used.", "In particular embodiments, a combination of two or more different MEK/ERK pathway inhibitors can be used.", "IV.", "Rho GTPase/ROCK Inhibitors The present invention provides for uses and compositions comprising inhibitors of the Rho-GTPase/ROCK pathway.", "The pathway includes the downstream protein Myosin II, which is further downstream of ROCK (Rho-ROCK-Myosin II forms the pathway/axis).", "Thus, one can use any or all of a Rho GTPase inhibitor, a ROCK inhibitor, or a Myosin II inhibitor to achieve the effects described herein.", "Those of skill will appreciate that the concentration of the Rho-GTPase/ROCK pathway inhibitor will depend on which specific inhibitor is used.", "In additional embodiments, a combination of two or more different Rho-GTPase/ROCK pathway inhibitors can be used.", "Any Rho GTPase should be effective in the methods and compositions of the invention.", "Inhibitors of Rho GTPase can include antibodies that bind, dominant negative variants of, and siRNA, microRNA, antisense nucleic acids, and other polynucleotides that target Rho GTPase.", "An exemplary Rho GTPase inhibitor is Clostridium botulinum C3 toxin.", "Any Myosin II inhibitor should be effective in the methods and compositions of the invention.", "Inhibitors of Myosin II can include antibodies that bind, dominant negative variants of, and siRNA, microRNA, antisense nucleic acids, and other polynucleotides that target Myosin II.", "An exemplary Myosin II inhibitor is blebbistatin.", "The inventors have found that blebbistatin can be substituted for SB431542 (an ALK5 inhibitor), albeit with a reduced effect, in the mixtures and methods described in the example section.", "Other inhibitors include but are not limited to those described in U.S. Pat.", "No.", "7,585,844.“ROCK” used herein refers to a serine/threonine kinase that acts downstream of Rho.", "ROCK I (also referred to as ROK β or p160ROCK) and ROCK II (also referred to as ROK α or Rho kinase) are both regulated by RhoA.", "See e.g., Riento, K. and Ridley, A. J., Nat.", "Rev.", "Mol.", "Cell.", "Biol., 4, 446-456 (2003).", "A “ROCK inhibitor” refers to agents that inhibit both or either of the ROCKs.", "Inhibitors of ROCK can include antibodies that bind, dominant negative variants of, and siRNA, microRNA, antisense nucleic acids, and other polynucleotides that target ROCK.", "Some exemplary ROCK inhibitors include, but are not limited to, those described in International Publication Nos.", ": WO98/06433, WO00/78351, WO01/17562, WO02/076976, WO02/076977, WO2003/062227, WO2003/059913, WO2003/062225, WO2002/076976, WO2004/039796, WO03/082808, WO05/035506, WO05/074643 and United States Patent Application Nos.", ": 2005/0209261, 2005/0192304, 2004/0014755, 2004/0002508, 2004/0002507, 2003/0125344 and 2003/0087919.ROCK inhibitors include, for example, (+)-(R)-trans-4-(1-aminoethyl)-N-(4-piridyl)cyclohexanecarboxamide dihydrochloride, or Wf536; 4-[(1R)-1-aminoethyll-N-(4-piridyl)benzamide monohydrochloride or Fasudil; 5-(hexahydro-1H-1,4-diazepin-1-ylsulfonyl)isoquinoline hydrochloride or Compound 1; 4-[(trans-4-aminocyclohexyl)amino]-2,5-difluorobenzamide or Compound 2; 4-[(trans-4-aminocyclohexyl)amino]-5-chloro-2-fluorobenzamide or Compound 3; 2-[4-(1H-indazol-5-yl)phenyl]-2-propanamine dihydrochloride or Compound 4; N-(3-methoxybenzyl)-4-(4-piridyl)benzamide, Y-27632 (see, e.g., Ishizaki et al., Mol.", "Pharmacol.", "57, 976-983 (2000); Narumiya et al., Methods Enzymol.", "325, 273-284 (2000)), Fasudil (also referred to as HA1077) (for example, refer to Uenata et al., Nature 389: 990-994 (1997)), sc-3536 (see, e.g., Darenfed, H., et al.", "Cell Motil.", "Cytoskeleton.", "64: 97-109, 2007), H-1152 (for example, refer to Sasaki et al., Pharmacol.", "Ther.", "93: 225-232 (2002)), Wf-536 (for example, refer to Nakajima et al., Cancer Chemother Pharmacol.", "52(4): 319-324 (2003)), Y-30141 (described in U.S. Pat.", "No.", "5,478,838) and derivatives thereof, and antisense nucleic acid for ROCK, RNA interference inducing nucleic acid (for example, siRNA), competitive peptides, antagonist peptides, inhibitory antibodies, antibody-ScFV fragments, dominant negative variants and expression vectors thereof.", "The above compounds may be made as acid addition salts with pharmaceutically acceptable inorganic acids or organic acids, as required.", "Examples of the acid addition salts include salts with mineral acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid and the like; salts with organic carboxylic acids such as formic acid, acetic acid, fumaric acid, maleic acid, oxalic acid, citric acid, malic acid, tartaric acid, aspartic acid and glutamic acid; and salts with sulfonic acids such as methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, hydroxybenzenesulfonic acid, dihydroxybenzene sulfonic acid and the like.", "The compounds and acid addition salts thereof may be an anhydride, hydrate or solvate thereof.", "To practice the present invention ROCK inhibitors generally are suitable without limitation so long as an inhibitor can inhibit the function of Rho-kinase (ROCK), and suitable inhibitors include Y-27632 (for example, refer to Ishizaki et al., Mol.", "Pharmacol.", "57, 976-983 (2000); Narumiya et al., Methods Enzymol.", "325, 273-284 (2000)), sc-3536 (see, e.g., Darenfed, H., et al.", "Cell Motil.", "Cytoskeleton.", "64: 97-109, 2007), Fasudil (also referred to as HA1077) (for example, refer to Uenata et al., Nature 389: 990-994 (1997)), H-1152 (for example, refer to Sasaki et al., Pharmacol.", "Ther.", "93: 225-232 (2002)), Wf-536 (for example, refer to Nakajima et al., Cancer Chemother Pharmacol.", "52(4): 319-324 (2003)), Y-30141 (described in U.S. Pat.", "No.", "5,478,838) and derivatives thereof, and antisense nucleic acid for ROCK, RNA interference inducing nucleic acid (for example, siRNA), competitive peptides, antagonist peptides, inhibitory antibodies, antibody-ScFV fragments, dominant negative variants and expression vectors thereof.", "Further, since other low molecular compounds are known as ROCK inhibitors, such compounds or derivatives thereof can be also used in the present invention (for example, refer to United State Patent Application Nos.", "20050209261, 20050192304, 20040014755, 20040002508, 20040002507, 20030125344 and 20030087919, and International Patent Publication Nos.", "2003/062227, 2003/059913, 2003/062225, 2002/076976 and 2004/039796).", "In the present invention, a combination of one or two or more of the ROCK inhibitors can also be used Additional ROCK inhibitors include, e.g., HA1100, 3-(4-Pyridyl)-1H-indole and N-(4-Pyridyl)-N′-(2,4,6-trichlorophenyl) urea, each of which is commercially available (e.g., from Alexis Biochemicals (Plymouth Meeting, Pa.).", "In some embodiments, ROCK inhibitors have the formula: In Formula (I), ring A is a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.", "Ring B is a substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl.", "L1 is —C(O)—NR2— or —NR2—C(O)—.", "L2 is a bond, substituted or unsubstituted alkylene or substituted or unsubstituted heteroalkylene.", "R1 and R2 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.", "In some embodiments, ring A is a substituted or unsubstituted aryl.", "Ring A may also be a substituted or unsubstituted phenyl.", "In other embodiments, ring B is a substituted or unsubstituted heterocycloalkyl, or substituted or unsubstituted heteroaryl.", "Ring B may also be a substituted or unsubstituted heteroaryl.", "In still other embodiments, ring B is a substituted or unsubstituted pyrazolyl, substituted or unsubstituted furanyl, substituted or unsubstituted imidazolyl, substituted or unsubstituted isoxazolyl, substituted or unsubstituted oxadiazolyl, substituted or unsubstituted oxazolyl, substituted or unsubstituted pyrrolyl, substituted or unsubstituted pyridyl, substituted or unsubstituted pyrimidyl, substituted or unsubstituted pyridazinyl, substituted or unsubstituted thiazolyl, substituted or unsubstituted triazolyl, substituted or unsubstituted thienyl, substituted or unsubstituted dihydrothieno-pyrazolyl, substituted or unsubstituted thianaphthenyl, substituted or unsubstituted carbazolyl, substituted or unsubstituted benzothienyl, substituted or unsubstituted benzofuranyl, substituted or unsubstituted indolyl, substituted or unsubstituted quinolinyl, substituted or unsubstituted benzotriazolyl, substituted or unsubstituted benzothiazolyl, substituted or unsubstituted benzooxazolyl, substituted or unsubstituted benzimidazolyl, substituted or unsubstituted isoquinolinyl, substituted or unsubstituted isoindolyl, substituted or unsubstituted acridinyl, substituted or unsubstituted benzoisazolyl, or substituted or unsubstituted dimethylhydantoin.", "L2 may be substituted or unsubstituted C1-C10 alkyl.", "In some embodiments, L2 is unsubstituted C1-C10 alkyl.", "L2 may also be substituted or unsubstituted methylene (e.g.", "unsubstituted methylene).", "R2 may be hydrogen.", "R1 may be hydrogen or unsubstituted C1-C10 alkyl.", "In some embodiments, R1 is simply hydrogen.", "In some embodiments of Formula (I), ring A is substituted or unsubstituted aryl, ring B is substituted or unsubstituted heteroaryl, R1 is hydrogen, and L2 is unsubstituted C1-C10 alkyl.", "In another embodiment, the ROCK inhibitor has the formula: In Formula (II), y is an integer from 0 to 3 and z is an integer from 0 to 5.X is —N═, —CH═ or —CR4═.", "R1 and L2 are as defined above in the definitions of Formula (I).", "R3, R4 and R5 are independently —CN, —S(O)nR6, —NR7R8, —C(O)R9, —NR10—C(O)R11, —NR12—C(O)—OR13, —C(O)NR14R15, —NR16S(O)2R17, —OR18, —S(O)2NR19, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein n is an integer from 0 to 2, wherein if z is greater than 1, two R3 moieties are optionally joined together to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.", "R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18 and R19 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.", "In some embodiments, L2 is substituted or unsubstituted C1-C10 alkyl.", "L2 may also be unsubstituted C1-C10 alkyl.", "Alternatively, L2 is substituted or unsubstituted methylene (e.g.", "unsubstituted methylene).", "In other embodiments, X is —N═ or —CH═.", "The symbol z may be 2.In still other embodiments, two R3 moieties at adjacent vertices are joined together to from a substituted or unsubstituted heterocycloalkyl.", "The symbol z may also be 1.The symbol y may be 0 or 1.R3 may be —OR18.R18 may be hydrogen or unsubstituted C1-C10 alkyl.", "In some embodiments, L2 is substituted or unsubstituted methylene (e.g.", "substituted methylene), X is —N═ or —CH═, R1 is hydrogen, and y and z are 0.In other embodiments, the compounds has the formula: V. GSK3 Inhibitors In various embodiments, one or more GSK3 inhibitors can be included in the methods, mixtures and kits of the invention.", "The inventors have found that the inclusion of GSK3 inhibitors with at least a TGFβ receptor/ALK5 inhibitor, preferably in combination with a MEK/ERK pathway inhibitor and in particular embodiments, a Rho GTPase/ROCK inhibitor.", "Inhibitors of GSK3 can include antibodies that bind, dominant negative variants of, and siRNA, microRNA, antisense nucleic acids, and other polynucleotides that target GSK3.Specific examples of GSK3 inhibitors include, but are not limited to, Kenpaullone, 1-Azakenpaullone, CHIR99021, CHIR98014, AR-A014418 (see, e.g., Gould, et al., The International Journal of Neuropsychopharmacology 7:387-390 (2004)), CT 99021 (see, e.g., Wagman, Current Pharmaceutical Design 10:1105-1137 (2004)), CT 20026 (see, Wagman, supra), SB216763 (see, e.g., Martin, et al., Nature Immunology 6:777-784 (2005)), AR-A014418 (see, e.g., Noble, et al., PNAS 102:6990-6995 (2005)), lithium (see, e.g., Gould, et al., Pharmacological Research 48: 49-53 (2003)), SB 415286 (see, e.g., Frame, et al., Biochemical Journal 359:1-16 (2001)) and TDZD-8 (see, e.g., Chin, et al., Molecular Brain Research, 137(1-2):193-201 (2005)).", "Further exemplary GSK3 inhibitors available from Calbiochem (see, e.g., Dalton, et al., WO2008/094597, herein incorporated by reference), include but are not limited to BIO (2′Z,3′£)-6-Bromoindirubin-3′-oxime (GSK3 Inhibitor IX); BIO-Acetoxime (2′Z,3′E)-6-Bromoindirubin-3′-acetoxime (GSK3 Inhibitor X); (5-Methyl-1H-pyrazol-3-yl)-(2-phenylquinazolin-4-yl)amine (GSK3-Inhibitor XIII); Pyridocarbazole-cyclopenadienylruthenium complex (GSK3 Inhibitor XV); TDZD-8 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (GSK3beta Inhibitor I); 2-Thio(3-iodobenzyl)-5-(1-pyridyl)-[1,3,4]-oxadiazole (GSK3beta Inhibitor II); OTDZT 2,4-Dibenzyl-5-oxothiadiazolidine-3-thione (GSK3beta Inhibitor III); alpha-4-Dibromoacetophenone (GSK3beta Inhibitor VII); AR-AO 14418 N-(4-Methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea (GSK-3beta Inhibitor VIII); 3-(1-(3-Hydroxypropyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-pyrazin-2-yl-pyrrole-2,5-dione (GSK-3beta Inhibitor XI); TWSl 19 pyrrolopyrimidine compound (GSK3beta Inhibitor XII); L803 H-KEAPPAPPQSpP-NH2 (SEQ ID NO:47) or its myristoylated form (GSK3beta Inhibitor XIII); 2-Chloro-1-(4,5-dibromo-thiophen-2-yl)-ethanone (GSK3beta Inhibitor VI); AR-AO144-18; SB216763; and SB415286.Residues of GSK3b that interact with inhibitors have been identified.", "See, e.g., Bertrand et al., J. Mol Biol.", "333(2): 393-407 (2003).", "GSK3 inhibitors can activate, for example, the Wnt/β-catenin pathway.", "Many of β-catenin downstream genes co-regulate pluripotency gene networks.", "For example, a GSK inhibitor activates cMyc expression as well as enhances its protein stability and transcriptional activity.", "Thus, in some embodiments, GSK3 inhibitors can be used to stimulate endogenous MYC polypeptide expression in a cell, thereby eliminating the need for MYC expression to induce pluripotency.", "Those of skill will appreciate that the concentration of the GSK3 inhibitor will depend on which specific inhibitor is used.", "In certain embodiments, a combination of two or more different GSK3 inhibitors can be used.", "VI.", "Methods of Inducing Pluripotency To date, a large number of different methods and protocols have been established for inducing non-pluripotent mammalian cells into induced pluripotent stem cells (iPSCs).", "It is believed that the agents described herein can be used in combination with essentially any protocol for generating iPSCs and thereby improve the efficiency of the protocol.", "Thus, the present invention provides for incubation of non-pluripotent cells with at least a TGFβ receptor/ALK5 inhibitor, preferably in combination with a MEK/ERK pathway inhibitor, and in particular embodiments, a Rho GTPase/ROCK inhibitor in combination with any protocol for generating iPSCs.", "A selection of protocols is described below and each is believed to be combinable with the agents of the invention to improve efficiency of the protocol.", "The improvement in efficiency of an iPSC generation protocol will depend on the protocol and which agents of the invention are used.", "In some embodiments, the efficiency is improved by at least 10%, 20%, 50%, 75%, 100%, 150%, 200%, 300% or more compared to the same protocol without inclusion of the agents of the invention (i.e., TGFβ receptor/ALK5 inhibitor, MEK/ERK pathway inhibitor and Rho GTPase/ROCK inhibitor).", "Efficiency is measured with regard to improvement of the number of iPSCs generated in a particular time frame or the speed by which iPSCs are generated.", "Studies have shown that retroviral transduction of mouse fibroblasts with four transcription factors that are highly expressed in ESCs (Oct-3/4, Sox2, KLF4 and c-Myc) generate induced pluripotent stem (iPS) cells.", "See, Takahashi, K. & Yamanaka, S. Cell 126, 663-676 (2006); Okita, K., Ichisaka, T. & Yamanaka, S. Nature 448, 313-317 (2007); Wernig, M. et al.", "Nature 448, 318-324 (2007); Maherali, N. et al.", "Cell Stem Cell 1, 55-70 (2007); Meissner, A., Wernig, M. & Jaenisch, R. Nature Biotechnol.", "25, 1177-1181 (2007); Takahashi, K. et al.", "Cell 131, 861-872 (2007); Yu, J. et al.", "Science 318, 1917-1920 (2007); Nakagawa, M. et al.", "Nature Biotechnol.", "26, 101-106 (2007); Wernig, M., Meissner, A., Cassady, J. P. & Jaenisch, R. Cell Stem Cell.", "2, 10-12 (2008).", "iPS cells are similar to ESCs in morphology, proliferation, and pluripotency, judged by teratoma formation and chimaera contribution.", "As noted above, while the original protocol involved introduction of four transcription factors into non-pluripotent cells, it has been more recently discovered that some transcription factors can be omitted.", "Thus, in some embodiments, the protocols involves introducing one, two or three of an Oct polypeptide, a Klf polypeptide, a Myc polypeptide, and a Sox polypeptide to non-pluripotent cells under conditions that allow for the non-pluripotent cells to become iPSCs.", "For example, each of Maherali and Konrad Hochedlinger, “Tgfβ Signal Inhibition Cooperates in the Induction of iPSCs and Replaces Sox2 and cMyc” Current Biology (2009) and WO/2009/117439 describe protocols that do not require all four transcription factors to induce pluripotency.", "Moreover, the inventors have found that iPSCs can be generated by introducing Oct4 alone into cells and incubating the cells with a TGFβ receptor/ALK5 inhibitor, a MEK/ERK pathway inhibitor, a Rho GTPase/ROCK inhibitor, and a histone deacetylase (HDAC) inhibitor.", "For example, introduction of exogenous Oct4 into mammalian cells, in the presence of a sufficient amount of SB431542, PD0325901, Tzv, and valproic acid or sodium butyrate, successfully generated iPSC cells.", "Exemplary HDAC inhibitors can include antibodies that bind, dominant negative variants of, and siRNA and antisense nucleic acids that target one or more HDACs.", "HDAC inhibitors include, but are not limited to, TSA (trichostatin A) (see, e.g., Adcock, British Journal of Pharmacology 150:829-831 (2007)), VPA (valproic acid) (see, e.g., Munster, et al., Journal of Clinical Oncology 25:18S (2007): 1065), sodium butyrate (NaBu) (see, e.g., Han, et al., Immunology Letters 108:143-150 (2007)), SAHA (suberoylanilide hydroxamic acid or vorinostat) (see, e.g., Kelly, et al., Nature Clinical Practice Oncology 2:150-157 (2005)), sodium phenylbutyrate (see, e.g., Gore, et al., Cancer Research 66:6361-6369 (2006)), depsipeptide (FR901228, FK228) (see, e.g., Zhu, et al., Current Medicinal Chemistry 3(3):187-199 (2003)), trapoxin (TPX) (see, e.g., Furumai, et al., PNAS 98(1):87-92 (2001)), cyclic hydroxamic acid-containing peptide 1 (CHAP1) (see, Furumai supra), MS-275 (see, e.g., Carninci, et al., WO2008/126932, incorporated herein by reference)), LBH589 (see, e.g., Goh, et al., WO2008/108741 incorporated herein by reference) and PXD101 (see, Goh, supra).", "In general, at the global level, pluripotent cells have more histone acetylation, and differentiated cells have less histone acetylation.", "Histone acetylation is also involved in regulation of histone and DNA methylation.", "In some embodiments, HDAC inhibitors facilitate activation of silenced pluripotency genes.", "To address the safety issues that arise from target cell genomes harboring integrated exogenous sequences, a number of modified genetic protocols have been further developed.", "These protocols produce iPS cells with potentially reduced risks, and include non-integrating adenoviruses to deliver reprogramming genes (Stadtfeld, M., et al.", "(2008) Science 322, 945-949), transient transfection of reprogramming plasmids (Okita, K., et al.", "(2008) Science 322, 949-953), piggyBac transposition systems (Woltjen, K., et al.", "(2009).", "Nature 458, 766-770, Kaji, K., et al.", "(2009) Nature 458, 771-775), Cre-excisable viruses (Soldner, F., et al.", "(2009) Cell 136, 964-977), and oriP/EBNA1-based episomal expression system (Yu, J., et al.", "(2009) Science DOI: 10.1126).", "Furthermore, strategies of exploiting endogenous gene expression in certain cell types also allowed easier reprogramming and/or with less required exogenous genes (Shi, Y., et al.", "(2008b).", "Cell Stem Cell 2, 525-528; Aasen, T., et al.", "(2008) Nat Biotechnol 26, 1276-1284; Kim, J.", "B., et al.", "(2008).", "Nature 454, 646-650).", "Moreover, small molecules have been identified that enhance reprogramming efficiency and replace certain reprogramming factors (Shi, Y., et al.", "(2008) Cell Stem Cell 2, 525-528, Shi, Y., et al.", "(2008) Cell Stem Cell 3, 568-574, Li, W., et al.", "(2009) Cell Stem Cell 4, 16-19; Huangfu, D., et al.", "(2008) Nat Biotechnol 26, 1269-1275, Huangfu, D., et al.", "(2008) Nat Biotechnol 26, 795-797).", "Moreover, recently, it has been shown that transcription factors can be delivered as exogenous protein to non-pluripotent cells, to generate iPSCs.", "See, e.g., WO/2009/117439; Zhou et al., Cell Stem Cell 4:381-384 (2009).", "One can introduce an exogenous polypeptide (i.e., a protein provided from outside the cell and/or that is not produced by the cell) into the cell by a number of different methods that do not involve introduction of a polynucleotide encoding the polypeptide.", "Thus, in some embodiments, non-pluripotent cells are contacted with a TGFβ receptor/ALK5 inhibitor, preferably in combination with a MEK/ERK pathway inhibitor, and in particular embodiments, a Rho GTPase/ROCK inhibitor and one or more exogenous transcription factor proteins, e.g., one, two, three or all four of an Oct polypeptide, a Klf polypeptide, a Myc polypeptide, and a Sox polypeptide.", "A variety of ways have been described for introducing the relevant protein factors into the target cells.", "In one embodiment, introduction of a polypeptide into a cell can comprise introduction of a polynucleotide comprising one or more expression cassettes into a cell and inducing expression, thereby introducing the polypeptides into the cell by transcription and translation from the expression cassette.", "Alternatively, one or more proteins can simply be cultured in the presence of target cells under conditions to allow for introduction of the proteins into the cell.", "See, e.g., Zhou H et al., Generation of induced pluripotent stem cells using recombinant proteins.", "Cell Stem Cell.", "2009 May 8; 4(5):381-4.In some embodiments, the exogenous proteins comprise the transcription factor polypeptide of interest linked (e.g., linked as a fusion protein or otherwise covalently or non-covalently linked) to a polypeptide that enhances the ability of the transcription factor to enter the cell (and in some embodiments the cell nucleus).", "Examples of polypeptide sequences that enhance transport across membranes include, but are not limited to, the Drosophila homeoprotein antennapedia transcription protein (AntHD) (Joliot et al., New Biol.", "3: 1121-34, 1991; Joliot et al., Proc.", "Natl.", "Acad.", "Sci.", "USA, 88: 1864-8, 1991; Le Roux et al., Proc.", "Natl.", "Acad.", "Sci.", "USA, 90: 9120-4, 1993), the herpes simplex virus structural protein VP22 (Elliott and O'Hare, Cell 88: 223-33, 1997); the HIV-1 transcriptional activator TAT protein (Green and Loewenstein, Cell 55: 1179-1188, 1988; Frankel and Pabo, Cell 55: 1 289-1193, 1988); delivery enhancing transporters such as described in U.S. Pat.", "No.", "6,730,293 (including but not limited to an peptide sequence comprising at least 7-25 contiguous arginines); and commercially available Penetratin™ 1 peptide, and the Diatos Peptide Vectors (“DPVs”) of the Vectocell® platform available from Daitos S. A. of Paris, France.", "See also, WO/2005/084158 and WO/2007/123667 and additional transporters described therein.", "Not only can these proteins pass through the plasma membrane but the attachment of other proteins, such as the transcription factors described herein, is sufficient to stimulate the cellular uptake of these complexes.", "In some embodiments, the transcription factor polypeptides described herein are exogenously introduced as part of a liposome, or lipid cocktail such as commercially available Fugene6 and Lipofectamine).", "In another alternative, the transcription factor proteins can be microinjected or otherwise directly introduced into the target cell.", "As discussed in the Examples of WO/2009/117439, incubation of cells with the transcription factor polypeptides of the invention for extended periods is toxic to the cells.", "Therefore, the present invention provides for intermittent incubation of non-pluripotent mammalian cells with one or more of a Klf polypeptide, an Oct polypeptide, a Myc polypeptide, and/or a Sox polypeptide, with intervening periods of incubation of the cells in the absence of the one or more polypeptides.", "In some embodiments, the cycle of incubation with and without the polypeptides can be repeated for 2, 3, 4, 5, 6, or more times and is performed for sufficient lengths of time (i.e., the incubations with and without proteins) to achieve the development of pluripotent cells.", "Various agents (e.g., MEK/ERK pathway inhibitor and/or GSK3 inhibitor and/or TGFbeta/ALK5 inhibitor and/or Rho GTPase/ROCK pathway inhibitor) can be included to improve efficiency of the method.", "The various inhibitors (e.g., TGFβ receptor/ALK5 inhibitor, MEK/ERK pathway inhibitor, and in particular embodiments, Rho GTPase/ROCK inhibitor, and/or GSK3 inhibitor, etc.)", "can be contacted to non-pluripotent cells either prior to, simultaneous with, or after delivery of, programming transcription factors (for example, delivered via expression cassette or as proteins).", "For convenience, the day the reprogramming factors are delivered is designated “day 1”.", "In some embodiments, the inhibitors are contacted to cells in aggregate (i.e., as a “cocktail”) at about days 3-7 and continued for 7-14 days.", "Alternatively, in some embodiments, the cocktail is contacted to the cells at day 0 (i.e., a day before the preprogramming factors) and incubated for about 14-30 days.", "In other embodiments, different inhibitors are added at different times.", "In some embodiments, at 1-7 days after the delivery of the reprogramming factors, the cells are contacted with compound combination of an TGFβ receptor/ALK5 inhibitor (e.g., SB431542) and a ROCK inhibitor for 1-8 days, followed by contacting the cells with the TGFβ receptor/ALK5 inhibitor, ROCK inhibitor and a MEK/ERK pathway inhibit (e.g., PD0325901) for 1-8 days.", "This can be optionally followed by contact with the TGFβ receptor/ALK5 inhibitor and MEK/ERK pathway inhibitor (but not necessarily the ROCK inhibitor) for 1-4 days, followed by contact with the MEK/ERK pathway inhibitor (but not the TGFβ receptor/ALK5 inhibitor or ROCK inhibitor), and optionally finally with basal (e.g., basal human) ES medium without inhibitors for 1-4 days.", "Other combinations can also be employed.", "IV.", "Transformation This invention employs routine techniques in the field of recombinant genetics.", "Basic texts disclosing the general methods of use in this invention include Sambrook et al., Molecular Cloning, A Laboratory Manual (3rd ed.", "2001); Kriegler, Gene Transfer and Expression: A Laboratory Manual (1990); and Current Protocols in Molecular Biology (Ausubel et al., eds., 1994)).", "In some embodiments, the species of cell and protein to be expressed is the same.", "For example, if a mouse cell is used, a mouse ortholog is introduced into the cell.", "If a human cell is used, a human ortholog is introduced into the cell.", "It will be appreciated that where two or more proteins are to be expressed in a cell, one or multiple expression cassettes can be used.", "For example, where one expression cassette expresses multiple polypeptides, a polycistronic expression cassette can be used.", "A. Plasmid Vectors In certain embodiments, a plasmid vector is contemplated for use to transform a host cell.", "In general, plasmid vectors containing replicon and control sequences which are derived from species compatible with the host cell are used in connection with these hosts.", "The vector can carry a replication site, as well as marking sequences which are capable of providing phenotypic selection in transformed cells.", "B.", "Viral Vectors The ability of certain viruses to infect cells or enter cells via receptor-mediated endocytosis, and to integrate into host cell genome and express viral genes stably and efficiently have made them attractive candidates for the transfer of foreign nucleic acids into cells (e.g., mammalian cells).", "Non-limiting examples of virus vectors that may be used to deliver a nucleic acid of the present invention are described below.", "i. Adenoviral Vectors A particular method for delivery of the nucleic acid involves the use of an adenovirus expression vector.", "Although adenovirus vectors are known to have a low capacity for integration into genomic DNA, this feature is counterbalanced by the high efficiency of gene transfer afforded by these vectors.", "“Adenovirus expression vector” is meant to include those constructs containing adenovirus sequences sufficient to (a) support packaging of the construct and (b) to ultimately express a tissue or cell-specific construct that has been cloned therein.", "Knowledge of the genetic organization or adenovirus, a ˜36 kb, linear, double-stranded DNA virus, allows substitution of large pieces of adenoviral DNA with foreign sequences up to 7 kb (Grunhaus et al., Seminar in Virology, 200(2):535-546, 1992)).", "ii.", "AAV Vectors The nucleic acid may be introduced into the cell using adenovirus assisted transfection.", "Increased transfection efficiencies have been reported in cell systems using adenovirus coupled systems (Kelleher and Vos, Biotechniques, 17(6):1110-7, 1994; Cotten et al., Proc Natl Acad Sci USA, 89(13):6094-6098, 1992; Curiel, Nat Immun, 13(2-3):141-64, 1994.).", "Adeno-associated virus (AAV) is an attractive vector system as it has a high frequency of integration and it can infect non-dividing cells, thus making it useful for delivery of genes into mammalian cells, for example, in tissue culture (Muzyczka, Curr Top Microbiol Immunol, 158:97-129, 1992) or in vivo.", "Details concerning the generation and use of rAAV vectors are described in U.S. Pat.", "Nos.", "5,139,941 and 4,797,368, each incorporated herein by reference.", "iii.", "Retroviral Vectors Retroviruses have promise as gene delivery vectors due to their ability to integrate their genes into the host genome, transferring a large amount of foreign genetic material, infecting a broad spectrum of species and cell types and of being packaged in special cell-lines (Miller et al., Am.", "J. Clin.", "Oncol., 15(3):216-221, 1992).", "In order to construct a retroviral vector, a nucleic acid (e.g., one encoding gene of interest) is inserted into the viral genome in the place of certain viral sequences to produce a virus that is replication-defective.", "To produce virions, a packaging cell line containing the gag, pol, and env genes but without the LTR and packaging components is constructed (Mann et al., Cell, 33:153-159, 1983).", "When a recombinant plasmid containing a cDNA, together with the retroviral LTR and packaging sequences is introduced into a special cell line (e.g., by calcium phosphate precipitation for example), the packaging sequence allows the RNA transcript of the recombinant plasmid to be packaged into viral particles, which are then secreted into the culture media (Nicolas and Rubinstein, In: Vectors: A survey of molecular cloning vectors and their uses, Rodriguez and Denhardt, eds., Stoneham: Butterworth, pp.", "494-513, 1988; Temin, In: Gene Transfer, Kucherlapati (ed.", "), New York: Plenum Press, pp.", "149-188, 1986; Mann et al., Cell, 33:153-159, 1983).", "The media containing the recombinant retroviruses is then collected, optionally concentrated, and used for gene transfer.", "Retroviral vectors are able to infect a broad variety of cell types.", "However, integration and stable expression typically involves the division of host cells (Paskind et al., Virology, 67:242-248, 1975).", "Lentiviruses are complex retroviruses, which, in addition to the common retroviral genes gag, pol, and env, contain other genes with regulatory or structural function.", "Lentiviral vectors are well known in the art (see, for example, Naldini et al., Science, 272(5259):263-267, 1996; Zufferey et al., Nat Biotechnol, 15(9):871-875, 1997; Blomer et al., J Virol., 71(9):6641-6649, 1997; U.S. Pat.", "Nos.", "6,013,516 and 5,994,136).", "Some examples of lentivirus include the Human Immunodeficiency Viruses: HIV-1, HIV-2 and the Simian Immunodeficiency Virus: SIV.", "Lentiviral vectors have been generated by multiply attenuating the HIV virulence genes, for example, the genes env, vif, vpr, vpu and nef are deleted making the vector biologically safe.", "Recombinant lentiviral vectors are capable of infecting non-dividing cells and can be used for both in vivo and ex vivo gene transfer and expression of nucleic acid sequences.", "For example, recombinant lentivirus capable of infecting a non-dividing cell wherein a suitable host cell is transfected with two or more vectors carrying the packaging functions, namely gag, pol and env, as well as rev and tat is described in U.S. Pat.", "No.", "5,994,136, incorporated herein by reference.", "One may target the recombinant virus by linkage of the envelope protein with an antibody or a particular ligand for targeting to a receptor of a particular cell-type.", "By inserting a sequence (including a regulatory region) of interest into the viral vector, along with another gene which encodes the ligand for a receptor on a specific target cell, for example, the vector is now target-specific.", "iv.", "Delivery Using Modified Viruses A nucleic acid to be delivered may be housed within an infective virus that has been engineered to express a specific binding ligand.", "The virus particle will thus bind specifically to the cognate receptors of the target cell and deliver the contents to the cell.", "A novel approach designed to allow specific targeting of retrovirus vectors was developed based on the chemical modification of a retrovirus by the chemical addition of lactose residues to the viral envelope.", "This modification can permit the specific infection of hepatocytes via sialoglycoprotein receptors.", "Another approach to targeting of recombinant retroviruses was designed in which biotinylated antibodies against a retroviral envelope protein and against a specific cell receptor were used.", "The antibodies were coupled via the biotin components by using streptavidin (Roux et al., Proc.", "Nat'l Acad.", "Sci.", "USA, 86:9079-9083, 1989).", "Using antibodies against major histocompatibility complex class I and class II antigens, they demonstrated the infection of a variety of human cells that bore those surface antigens with an ecotropic virus in vitro (Roux et al., 1989).", "C. Vector Delivery and Cell Transformation Suitable methods for nucleic acid delivery for transformation of a cell, a tissue or an organism for use with the current invention are believed to include virtually any method by which a nucleic acid (e.g., DNA) can be introduced into a cell, a tissue or an organism, as described herein or as would be known to one of ordinary skill in the art.", "Such methods include, but are not limited to, direct delivery of DNA such as by ex vivo transfection (Wilson et al., Science, 244:1344-1346, 1989, Nabel and Baltimore, Nature 326:711-713, 1987), optionally with Fugene6 (Roche) or Lipofectamine (Invitrogen), by injection (U.S. Pat.", "Nos.", "5,994,624, 5,981,274, 5,945,100, 5,780,448, 5,736,524, 5,702,932, 5,656,610, 5,589,466 and 5,580,859, each incorporated herein by reference), including microinjection (Harland and Weintraub, J.", "Cell Biol., 101:1094-1099, 1985; U.S. Pat.", "No.", "5,789,215, incorporated herein by reference); by electroporation (U.S. Pat.", "No.", "5,384,253, incorporated herein by reference; Tur-Kaspa et al., Mol.", "Cell Biol., 6:716-718, 1986; Potter et al., Proc.", "Nat'l Acad.", "Sci.", "USA, 81:7161-7165, 1984); by calcium phosphate precipitation (Graham and Van Der Eb, Virology, 52:456-467, 1973; Chen and Okayama, Mol.", "Cell Biol., 7(8):2745-2752, 1987; Rippe et al., Mol.", "Cell Biol., 10:689-695, 1990); by using DEAE-dextran followed by polyethylene glycol (Gopal, Mol.", "Cell Biol., 5:1188-1190, 1985); by direct sonic loading (Fechheimer et al., Proc.", "Nat'l Acad.", "Sci.", "USA, 84:8463-8467, 1987); by liposome mediated transfection (Nicolau and Sene, Biochim.", "Biophys.", "Acta, 721:185-190, 1982; Fraley et al., Proc.", "Nat'l Acad.", "Sci.", "USA, 76:3348-3352, 1979; Nicolau et al., Methods Enzymol., 149:157-176, 1987; Wong et al., Gene, 10:87-94, 1980; Kaneda et al., Science, 243:375-378, 1989; Kato et al., J Biol.", "Chem., 266:3361-3364, 1991) and receptor-mediated transfection (Wu and Wu, Biochemistry, 27:887-892, 1988; Wu and Wu, J. Biol.", "Chem., 262:4429-4432, 1987); and any combination of such methods, each of which is incorporated herein by reference.", "VII.", "Mixtures The present invention provides for mixtures that improve the efficiency of generation of iPSCs For example, the invention provides for mixtures of a TGFβ receptor/ALK5 inhibitor, a MEK/ERK pathway inhibitor, a Rho GTPase/ROCK inhibitor, in particular embodiments, with mammalian cells.", "For example, the mixtures can be included in cell culture media, with or without cells.", "The contents of cell culture media are generally known in the art.", "Exemplary cell culture media are described in detail in the Examples.", "Generally, cell cultures comprising mammalian cells and agents of the invention (TGFβ receptor/ALK5 inhibitor, a MEK/ERK pathway inhibitor, and a Rho GTPase/ROCK inhibitor) will initially contain all or substantially all non-pluripotent cells.", "However, over time, especially under the conditions of the protocols described here, a portion of the cells will become pluripotent (i.e., iPSCs).", "Cells to be induced to pluripotency can be cultured according to any method known in the art.", "General guidelines for culture conditions to generate iPSCs can be found in, e.g., Maherali, et al., Cell Stem Cell 3:595-605 (2008).", "In some embodiments, the cells are cultured in contact with feeder cells.", "Exemplary feeder cells include, but are not limited to fibroblast cells, e.g., mouse embryonic fibroblast (MEF) cells.", "Methods of culturing cells on feeder cells are known in the art.", "In some embodiments, the cells are cultured in the absence of feeder cells.", "Cells, for example, can be attached directly to a solid culture surface (e.g., a culture plate), e.g., via a molecular tether.", "The inventors have found that culturing cells induced to pluripotency have a much greater efficiency of induction to pluripotency (i.e., a greater portion of cells achieve pluripotency) when the cells are attached directly to the solid culturing surface compared the efficiency of otherwise identically-treated cells that are cultured on feeder cells.", "Exemplary molecular tethers include, but are not limited to, Matrigel®, an extracellular matrix (ECM), ECM analogs, laminin, fibronectin, or collagen.", "Those of skill in the art however will recognize that this is a non-limiting list and that other molecules can be used to attach cells to a solid surface.", "Methods for initial attachment of the tethers to the solid surface are known in the art.", "As described herein, in some embodiments, the mixtures of the invention can include or exclude mammalian cells (including pluripotent or non-pluripotent cells), and one or more of a HDAC inhibitor, GSK3 inhibitor, or an L-type Ca channel agonist; an activator of the cAMP pathway; a DNA methyltransferase (DNMT) inhibitor; a nuclear receptor ligand, e.g., as described in PCT WO/2009/117439.VIII.", "Kits The present invention also provides kits, e.g., for use in generating induced pluripotent stem cells.", "Such kits can comprise any or all of the reagents described herein, including but not limited to: a TGFβ receptor/ALK5 inhibitor, a MEK/ERK pathway inhibitor, and/or a Rho GTPase/ROCK inhibitor, as described herein.", "These three agents, or subsets thereof, can be present in the kit in separate vials, or together as a mixture.", "The kits of the invention can also include, one or more of an HDAC inhibitor, a GSK3 inhibitor, or an L-type Ca channel agonist; an activator of the cAMP pathway; a DNA methyltransferase (DNMT) inhibitor; and a nuclear receptor ligand.", "In one embodiment, the kits of the invention will include one or more types of mammalian (e.g., human, mouse, rat, etc.)", "cells and/or cell culture media.", "In a particular embodiment, the kits of the invention will include one or more polynucleotides comprising expression cassettes for expression of one or more of Oct polypeptide, a Klf polypeptide, a Myc polypeptide, and a Sox polypeptide.", "In addition, or alternatively, the kits can comprise one or more isolated transcription factor proteins, e.g., one, two, three or all four of an Oct polypeptide, a Klf polypeptide, a Myc polypeptide, and a Sox polypeptide.", "In another particular embodiment, the transcription factor proteins can be fused to a polypeptide sequence for enhancing transport of the transcription factor proteins across cell membranes.", "VI.", "Uses for Pluripotent Cells The present invention allows for the further study and development of stem cell technologies, including but not limited to, prophylactic or therapeutic uses.", "For example, in some embodiments, cells of the invention (either pluripotent cells or cells induced to differentiate along a desired cell fate) are introduced into individuals in need thereof, including but not limited to, individuals in need of regeneration of an organ, tissue, or cell type.", "In some embodiments, the cells are originally obtained in a biopsy from an individual; induced into pluripotency as described herein, optionally induced to differentiate (for examples into a particular desired progenitor cell) and then transplanted back into the individual.", "In some embodiments, the cells are genetically modified prior to their introduction into the individual.", "In some embodiments, the pluripotent cells generated according to the methods of the invention are subsequently induced to form, for example, hematopoietic (stem/progenitor) cells, neural (stem/progenitor) cells (and optionally, more differentiated cells, such as subtype specific neurons, oligodendrocytes, etc), pancreatic cells (e.g., endocrine progenitor cell or pancreatic hormone-expressing cells), hepatocytes, cardiovascular (stem/progenitor) cells (e.g., cardiomyocytes, endothelial cells, smooth muscle cells), retinal cells, etc.", "A variety of methods are known for inducing differentiation of pluripotent stem cells into desired cell types.", "A non-limiting list of recent patent publications describing methods for inducing differentiation of stem cells into various cell fates follows: U.S. Patent Publication Nos.", ": 2007/0281355; 2007/0269412; 2007/0264709; 2007/0259423; 2007/0254359; 2007/0196919; 2007/0172946; 2007/0141703; 2007/0134215.A variety of diseases may be ameliorated by introduction, and optionally targeting, of pluripotent cells of the invention to a particular injured tissue.", "Examples of disease resulting from tissue injury include, but are not limited to, neurodegeneration disease, cerebral infarction, obstructive vascular disease, myocardial infarction, cardiac failure, chronic obstructive lung disease, pulmonary emphysema, bronchitis, interstitial pulmonary disease, asthma, hepatitis B (liver damage), hepatitis C (liver damage), alcoholic hepatitis (liver damage), hepatic cirrhosis (liver damage), hepatic insufficiency (liver damage), pancreatitis, diabetes mellitus, Crohn disease, inflammatory colitis, IgA glomerulonephritis, glomerulonephritis, renal insufficiency, decubitus, burn, sutural wound, laceration, incised wound, bite wound, dermatitis, cicatricial keloid, keloid, diabetic ulcer, arterial ulcer, and venous ulcer.", "In one embodiment, iPSCs can be used in various assays and screen to identify molecules that modulate their function, including but not limited to promoting iPSC survival and/or differentiation.", "EXAMPLES The following examples are offered to illustrate, but not to limit the claimed invention.", "Example 1: A Chemical Platform for Improved Induction of Human iPSCs Mesenchymal type fibroblasts reprogrammed with the “four-factors” (OCT4, SOX2, KLF4 & c-MYC; 4TFs hereafter) underwent dramatic morphological changes that resulted in iPSCs with distinct cell polarity, boundaries and cell-cell interactions.", "The reprogrammed cells expressed E-cadherin, a marker for epithelial cells (Hay, E. D., Acta Anat.", "(Basel) 154, 8-20 (1995)), which is also highly expressed in human embryonic stem cells (hESCs).", "We reasoned that factors that promote the mesenchymal to epithelial transition (MET), such as TGFβ pathway antagonists, would have a direct impact on the reprogramming process.", "In addition, MEK-ERK pathway inhibition was previously shown to play an important role in various steps of reprogramming (Chen, S. et al., Proc.", "Natl.", "Acad.", "Sci.", "USA 104, 10482-87 (2007); Shi, Y. et al., Cell Stem Cell 2, 525-8 (2008)).", "Furthermore, factors promoting cell survival could also be beneficial in improving reprogramming efficiency.", "Consequently, we focused on small molecules that can regulate these three processes and pathways, as small molecules have many advantages (Feng, B. et al., Cell Stem Cell 4, 301-12 (2009); Shi, Y. et al., Cell Stem Cell 2, 525-8 (2008); Xu, Y. et al., Nature 453, 338-44 (2008)) in studying biological processes and are a safer choice than genetic manipulation.", "Here we describe a simple chemical platform that substantially enhances generation of fully reprogrammed human iPSCs from fibroblasts through a much faster and more efficient process.", "We tested known inhibitors of the TGFβ receptor and MEK on 1×104 (Feng, B. et al., Cell Stem Cell 4, 301-12 (2009)) human primary fibroblasts (CRL2097 or BJ) that were retrovirally transduced with the 4TFs, for their effect on reprogramming kinetics and efficiency (see FIG.", "1a for details).", "On day 7 (D7) post-infection, the compounds were added, individually or in combinations, and the cultures were examined for iPSCs over the next 1-3 weeks.", "On day 7 post-treatment (D14), we observed the strongest effect in the cultures treated with a combination of ALK5 inhibitor SB431542 (2 μM) and MEK inhibitor PD0325901 (0.5 μM), which resulted in ˜45 large ALP+ colonies (FIG.", "1b) with characteristic hESC-like morphology, of which over 24 colonies were TRA-1-81+ (FIG.", "1d), and about 6-10 colonies stained positive for SSEA4 and NANOG, a mature pluripotency factor that is not ectopically introduced (FIGS.", "1e and 10.Moreover, the treated cultures showed high level expression of endogenous mRNA for the pluripotency genes (FIG.", "1c).", "In contrast, no NANOG colonies were observed in the untreated control cultures (FIG.", "1e & FIG.", "4a) or in cultures that were treated with PD0325901 alone (FIG.", "4a).", "However, in the cultures treated with only SB431542, we still observed 1-2 ALP+ hESC-like colonies (FIG.", "4a).", "Importantly, the combined effect of both the inhibitors (FIGS.", "4b & 4c), as well as the individual effect of SB431542 was dose dependent.", "When we maintained the SB431542 plus PD0325901 treated cultures for 30 days without splitting, we obtained about 135 iPSC colonies per well (FIG.", "2d), a >100 fold improvement in efficiency over the conventional method.", "Consistent with previous reports (Takahashi, K. et al., Cell 131, 861-72 (2007)), in untreated controls carrying 4TFs, we observed 1-2 iPSC colonies in addition to several granulate colonies (FIG.", "2c).", "These granulate structures have been suggested to be partially reprogrammed colonies (Takahashi, K. et al., Cell 131, 861-72 (2007)).", "We also observed granulate colonies in the SB431542 treated cultures, which outnumbered by several fold the few hESC-like colonies.", "Interestingly, the number of granulate colonies was dramatically reduced in the combined SB431542 and PD0325901 treatment, which resulted in a concomitant increase in the number of hESC-like colonies.", "This suggested that a combined inhibition of ALK5 and MEK may guide partially reprogrammed colonies to a fully reprogrammed state and thereby improve the overall reprogramming process.", "Moreover, the fact that we observed improved induction of iPSCs as early as 7 days post-treatment suggests that treatment with these small molecules not only improved the efficiency of the reprogramming process but may also have accelerated its kinetics (FIG.", "1a).", "Additional experiments are required to determine whether the reprogrammed cells at this stage indeed become fully independent of exogenous reprogramming factors earlier than in untreated cultures.", "Although iPSC colonies were picked and expanded, as in hESC cultures, the cultures split by trypsinization resulted in poor survival.", "From a recent screen performed in our laboratory we identified a novel small molecule, Thiazovivin (FIG.", "7), which dramatically improved the survival of hESCs upon trypsinization.", "Addition of Thiazovivin to our cocktail of SB431542 and PD0325901 also vastly improved the survival of iPSCs after splitting by trypsinization (FIG.", "2a), and a large number of reprogrammed colonies were obtained.", "From 10,000 cells that were originally seeded, a single 1:4 splitting on day 14 resulted in 1,000 hESC-like colonies on day 30 (FIG.", "2e), while two rounds of splitting (on day 14 and on day 21 (1:10)) resulted in 11,000 hESC-like colonies (FIGS.", "2c & 2e) on day 30.These colonies showed high levels of endogenous mRNA (FIG.", "20 and protein expression (FIGS.", "2b & 2c) of pluripotency markers, while the expression of the four transgenes could hardly be detected (FIG.", "20.In contrast, no iPSC colonies were obtained from untreated or 2 compound-treated samples that were trypsinized (Table 1).", "TABLE 1 A comparison of the number of iPSC colonies observed in untreated, 2 compound treated and 3 compound treated cultures on day 30.No compound 2 compounds 3 compounds No splitting 1 135 205 1 splitting (on day 14) 0 0 900 2 splitting (on day 14 & N/A N/A 11,000 day 21) To examine whether the positive effect of Thiazovivin is solely due to survival of colonies after splitting or whether it also augments the reprogramming effect of combined SB431542 and PD0325901 treatment, we tested the 3 compound cocktail on 4TF-transduced cells that were not subjected to splitting.", "In these cultures, by day 14 we observed ˜25 large colonies that were all expressing Nanog (FIG.", "1e).", "By day 30 we observed ˜205 very large NANOG+ colonies (FIG.", "2d), that were also TRA-1-81+ and SSEA4+ (data not shown), which translated to a more than 200 fold improvement in efficiency over no compound treatment, and a two-fold increase over 2 compound treatment.", "Two compound treatment also resulted in a larger number of alkaline phosphatase-positive colonies compared to untreated controls when the reprogramming factors were introduced using a lentiviral, rather than a retroviral system (FIG.", "6a).", "Furthermore, the 3 compound cocktail did not appear to influence reprogramming factor expression from retroviral vectors (FIG.", "6b-f).", "The iPSC colonies generated using the 3 compound cocktail were readily and stably expanded for long term under conventional hESC culture conditions (over 20 passages) and they closely resembled hESCs in terms of morphology, typical pluripotency marker expression and differentiation potentials.", "They exhibited a normal karyotype (FIG.", "5) and could be differentiated into derivatives of all three germ layers, both in vitro (FIGS.", "3a & 3b) and in vivo (FIG.", "3c).", "These results also suggested that there is no short term adverse effect associated with the much more convenient trypsinization procedure.", "The demonstration that TGFβ and MEK-ERK pathway inhibition improved fibroblast reprogramming suggested critical roles for these two signaling pathways and MET mechanisms in the process.", "Consistently, addition of TGFβ had an inhibitory effect on 4 factor-mediated reprogramming of fibroblasts (data not shown).", "TGFβ and its family members play important contextual roles in self-renewal and differentiation of ESCs (Watabe, T. and Miyazono, K., Cell Res.", "19, 103-15 (2009)).", "Moreover, TGFβ is a prototypical cytokine for induction of epithelial mesenchymal transition (EMT) and maintenance of the mesenchymal state (Willis, B. C. and Borok, Z., Am.", "J. Physiol.", "Lung Cell Mol.", "Physiol.", "293, L525-34 (2007)).", "A major end point of this signaling, in this context, is down regulation of E-cadherin (Thiery, J. P. and Sleeman, J. P., Nat.", "Rev.", "Mol.", "Cell Biol., 7, 131-42 (2006)).", "E-cadherin has been shown to be important for the maintenance of pluripotency of ESCs and has been recently suggested to be a regulator of NANOG expression (Chou, Y. F. et al., Cell 135, 449-61 (2008)).", "Therefore inhibition of TGFβ signaling, which results in de-repression of epithelial fate, could benefit the reprogramming process in multiple ways.", "ERK signaling also promotes EMT (Thiery, J. P. and Sleeman, J. P., Nat.", "Rev.", "Mol.", "Cell Biol.", "7, 131-42 (2006)), and is downstream of TGFβ in the process (Chou, Y. F. et al., Cell 135, 449-61 (2008)).", "We had previously shown that the effect of reversine, a small molecule which can reprogram myoblasts to a multipotent state, is mediated in part through inhibition of MEK-ERK (Chen, S. et al., Proc.", "Natl.", "Acad.", "Sci.", "USA 104, 10482-87 (2007)).", "This may explain the effect observed in reprogramming when it was combined with TGFβ inhibition.", "The chemical platform described here is unique, in that it modulates upstream signaling pathways and could radically improve reprogramming on a general cell type, like fibroblasts.", "The chemical conditions described here provide a basic platform for non-viral and non-DNA based (Zhou, H. et al., Cell Stem Cell 4, 381-84, (2009)), more efficient and safer reprogramming methods, which could yield an unlimited supply of safe human iPSCs for various applications.", "Methods Cell Culture Primary skin fibroblasts CRL2097 and BJ (neonatal foreskin) were purchased from ATCC.", "All cell culture media reagents were purchased from Invitrogen Corporation, CA.", "The cells were maintained in DMEM (10313-021) containing 10% FBS (10439-024), 1×MEM Non-Essential Amino acid (11140-050), 1× Glutamax (35050-061), 10 mM Hepes (15630-080) and 0.11 mM 2-Mercaptoethanol (21985-023).", "Cells were passaged 1:5 using 0.05% (1×) trypsin-EDTA (25300-054).", "Plasmids The pMXs vector encoding the human cDNAs for OCT4, SOX2, c-MYC and KLF4, described before (Takahashi, K. et al., Cell 131, 861-72 (2007)), were obtained from ADDGENE.", "Mouse Slc7a1 ORF was cloned into pWPXLD (Addgene), as described previously (Takahashi, K. et al., Cell 131, 861-72 (2007)).", "Retroviral Infection and iPS Cell Generation Lentiviruses carrying OCT4, NANOG, SOX2 & LIN28 were produced as described before (Yu, J. et al., Science 318, 1917-20 (2007)).", "For retrovirus production, PLAT-E packaging cells were plated at 1×106 cells/well of a 6-well plate.", "After 24 hours, the cells were transfected with pMXs vectors carrying OCT4, SOX2, c-MYC and KLF4 cDNAs using Fugene 6 transfection reagent (Roche) according to manufacturer's instructions.", "Twenty-four hours after transfection, the medium was replaced with fresh medium and the plate was transferred to 32° C. for retrovirus production.", "The viruses were collected at 48 hours and 72 hours, and filtered with 0.45 μm filter before transduction.", "The Slc7a1-expressing human fibroblast cells were seeded at 1×105 cells/well of a 6 well plate on the day 1.On day 2, 0.25 ml of each retroviral supernatant was added to the cells in the presence of 6 μg/ml polybrene.", "A second round of transduction was done on day 3.Infection efficiency was estimated by fluorescence microscopy on cells transduced in parallel with GFP or RFP gene-carrying retroviruses.", "Seven days after initial transduction, fibroblasts were harvested by trypsinization and re-plated at 1×104 cells/well of a 6 well plate coated with matrigel (1:50 dilution, cat 354234, BD Biosciences).", "For compound treatment, the cells were cultured in human reprogramming medium (DMEM/F12, 20% Knockout serum replacer, lx MEM Non-Essential amino acid, lx glutamax, 0.11 mM 2-Mercaptoethanol, 20 ng/ml bFGF and 1,000 U/ml LIF) and were treated with 2 μM SB431542 (Stemgent), 0.5 μM PD0325901 (Stemgent), 0.5 μM Thiazovivin, or combinations of the compounds.", "The media were changed every 2-3 days depending on the cell density.", "Seven days after compound treatment, either the plates were fixed and stained for Alkaline phosphatase (ALP) activity, or stained for protein markers, or the cultures were continued with or without indicated splitting by trypsinization till day 30.For split cultures, the cells were split (1:4) and re-plated onto irradiated CF-1 MEF feeder layer (2.5×105 cells/well) in each well of 6 well plate and were split (1:10) again on day 21.The cells were maintained in the same media and compound cocktail described above except for the concentrations of PD0325901 (0.5 μM for D14 and 1 μM for D21) and SB431542 (0.5-1 μM after D14).", "The iPSC colonies were subsequently maintained in conventional hESC media in the absence of the above compounds.", "Alkaline Phosphatase Staining and Immunocytochemistry Alkaline phosphatase staining was performed using ALP detection kit (cat no: SCR004, Chemicon) according to the product instructions.", "For immunocytochemistry, cells were fixed in 4% paraformaldehyde (10 min, RT), washed twice with PBS, blocked using 5% normal donkey serum (Chemicon) and 0.1% TritonX-100 (15 min, RT) and then treated with primary antibodies overnight at 4° C. The primary antibodies used were anti-NANOG (cat no: AB9220, Chemicon, 1:1,000); anti-OCT4 (cat no: sc-5279, Santa Cruz biotech, 1:200), anti-SSEA 4 (cat no: mab4304, Chemicon, 1:500), anti-Tra-1-81 (cat 560123, BD Biosciences, 1:100), anti-Tra-1-81 (mAb 4381, Chemicon, 1:500), anti-βIII TUBULIN (cat no: MMS-435P, Covance Research Products Inc, 1:1000), anti-PDX 1 (1:500) (a kind gift from Dr. C. Wright), anti-BRACHYURY (cat No: AF2085, R & D, final concentration 0.2 μg/ml).", "The cells were washed twice with PBS and then treated with secondary antibodies for 1 hour at room temperature.", "The secondary antibodies used were Alexa fluor 488 donkey anti-rabbit or anti-mouse IgG (Invitrogen, 1:1,000) and Alexa fluor 555 donkey anti-rabbit or anti-mouse IgG (Invitrogen, 1:1,000).", "Nuclei were stained with 0.5 μg/ml DAPI (Sigma).", "Images were captured using a Nikon Eclipse TE2000-U/X-cite 120 EXFO microscope with a photometric CoolSnap HQ2 camera.", "In Vitro Differentiation and Teratoma Assay Generation of embryoid bodies and in vitro differentiation were performed as described elsewhere (Takahashi, K. et al., Cell 131, 861-72 (2007)).", "For the teratoma assay, 3-5 million cells were injected under the kidney capsule of SCID mice.", "Thirty one days later the tumors were excised and fixed in 4% paraformaldehyde and histologically analyzed at the TSRI histology core facility.", "The use of SCID mice was approved by the UCSD animal research committee.", "RT-PCR Total RNA was extracted from cells using RNeasy minikit (Qiagen).", "cDNAs were synthesized according to product instructions using superscript III first strand synthesis kit (Invitrogen).", "Two microliters of the reaction product was used for 24-28 PCR cycles using respective primers.", "The sequences of the primers are described elsewhere (Takahashi, K. et al., Cell 131, 861-72 (2007)).", "Flow Cytometry For flow cytometry analysis, the cultures were mildly trypsinized and harvested from 6 well plates.", "The cells were washed and resuspended in FACS buffer (PBS, 2 mM EDTA, 2 mM HEPES, 1% FBS), and were analyzed on a FACS Calibur cytometer (Becton Dickinson, San Jose, Calif.) with the CellQuest program.", "Example 2: Synthesis of N-(cyclopropylmethyl)-4-(4-(6-hydroxy-3,4-dihydroquinolin-1(2H)-yl)pyrimidin-2-ylamino)benzenesulfonamide (Thiazovivin) The reaction flask containing 2,4-dichloropyrimidine (372 mg, 2.5 mmol), 6-methoxy-1,2,3,4-tetrahydroquinoline (489 mg, 3 mmol) and diisopropylethylamine (0.52 mL, 3 mmol) in n-butanol (10 mL) was heated at 40° C. overnight.", "The solvent was evaporated, and the residue was purified by flash column chromatography to give 2-Chloro-4-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)pyrimidine (551 mg, 80%).", "This intermediate (250 mg, 0.91 mmol) was then dissolved in dichloromethane and treated with BBr3 (1 M in dichloromethane) (1 mL, 1 mmol) at −78° C. The reaction mixture was slowly warmed up to room temperature and stirred for 1 hr, poured into water, extracted with dichloromethane.", "The combined organics were dried over anhydrous Na2SO4 and concentrated.", "The residue was purified by flash column chromatography to give 2-Chloro-4-(6-hydroxy-3,4-dihydroquinolin-1(2H)-yl)pyrimidine (154 mg, 65%).", "To a stirred solution of 2-chloro-4-(6-hydroxy-3,4-dihydroquinolin-1(2H)-yl)pyrimidine (29 mg, 0.11 mmol) and 4-amino-N-(cyclopropylmethyl)benzenesulfonamide (27 mg, 0.12 mmol) in DMF (0.5 mL) was added p-toluenesulfonic acid (2 M in dioxane) (55 μL, 0.11 mmol).", "The reaction mixture was stirred at 90° C. overnight, then purified by HPLC to give the title compound (27 mg, 56%).", "Example 3: Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds Here we report a novel small molecule cocktail that enables reprogramming of human primary somatic cells to iPSCs with exogenous expression of only OCT4.Among several readily available primary human somatic cell types, keratinocytes that can be easily isolated from human skin or hair follicle represent an attractive cell source for reprogramming, because they endogenously express KLF4 and cMYC, and were reported to be reprogrammed more efficiently using the conventional four TFs or three TFs (without MYC) (Aasen, T. et al., Nat Biotechnol 26:1276-1284 (2008); Maherali, N. et al., Cell Stem Cell 3, 340-345(2008)).", "More recently, we reported that dual inhibition of TGFβ and MAPK/ERK pathways using small molecules (i.e.", "SB431542 and PD0325901, respectively) provides a drastically enhanced condition for reprogramming of human fibroblasts with four exogenous TFs (i.e.", "OSKM) (Lin, T. et al., Nat Methods 6:805-808 (2009)).", "Furthermore, we have shown that such dual pathway inhibition could also enhance reprogramming of human keratinocytes by two exogenous TFs (i.e.", "OK) with two small molecules, Parnate (an inhibitor of lysine-specific demethylase 1) and CHIR99021 (a GSK3 inhibitor) (Li, W. et al., Stem Cells 27:2992-3000 (2009)).", "However, such 2-TFs reprogramming process was very inefficient and complex (e.g.", "involving two exogenous TFs and four chemicals), and reprogramming with even one less TF appeared daunting.", "Toward the OCT4 only reprogramming, we developed a step-wise strategy in refining reprogramming condition and identifying new reprogramming chemical entities.", "We first attempted to further optimize the reprogramming process under the four or three TFs (i.e.", "OSKM or OSK) condition in neonatal human epidermal keratinocytes (NHEKs) by testing various inhibitors of TGFβ and MAPK pathways at different concentrations using previously reported human iPSC characterization methods (Lin, T. et al., Nat Methods 6:805-808 (2009)).", "Encouragingly, we found that the combination of 0.5 μM PD0325901 and 0.5 μM A-83-01 (a more potent and selective TGFβ receptor inhibitor) was more effective in enhancing reprogramming of human keratinocytes transduced with OSKM or OSK (FIG.", "8a).", "Remarkably, when we further reduced viral transductions to only two factors/OK, we could still generate iPSCs from NHEKs when they were treated with 0.5 μM PD0325901 and 0.5 μM A-83-01, although with low efficiency.", "Then we began screening additional small molecules from a collection of known bioactive compounds at various concentrations as previously reported.", "Among dozens of compounds tested so far, surprisingly we found that a small molecule activator of PDK1 (3′-phosphoinositide-dependent kinase-1), PS48 (5 μM) that has never been reported in reprogramming, can significantly enhance the reprogramming efficiency about fifteen fold.", "Interestingly, we also found that 0.25 mM sodium butyrate (NaB, a histone deacetylase inhibitor) turned out to be much more reliable and efficient than the previously reported 0.5 mM VPA for the generation of iPSCs under OK condition (FIG.", "8b).", "Subsequent follow-up studies demonstrated that combination of 5 μM PS48 and 0.25 mM NaB could further enhance the reprogramming efficiency over twenty-five fold (FIG.", "8b and Table 4).", "With such unprecedented efficiency in reprogramming NHEKs under only two TFs, we further explored the possibility of generating iPSCs with OCT4 alone by refining combinations of those small molecules during different treatment windows.", "Primary NHEKs were transduced with OCT4 and treated with chemicals (FIG.", "8c).", "Among various conditions, small iPSC colonies resembling hESCs (four to six colonies out of 1,000,000 seeded cells) appeared in OCT4 infected NHEKs that were treated with 0.25 mM NaB, 5 μM PS48 and 0.5 μM A-83-01 during the first four weeks, followed by treatment with 0.25 mM NaB, 5 μM PS48, 0.5 μM A-83-01 and 0.5 μM PD0325901 for another four weeks (FIG.", "8c).", "Such TRA-1-81 positive iPSC colonies (FIG.", "8d) grew larger under conventional hESC culture media and could be serially passaged to yield stable iPSC clones that were further characterized (FIGS.", "8e and 9).", "More significantly, OCT4 only iPSCs could also be generated from human adult keratinocytes by addition of 2 μM Parnate and 3 μM CHIR99021 (which had been shown to improve reprogramming of NHEKs under OK condition) to this chemical cocktail.", "After the reliable reprogramming of primary keratinocytes to iPSCs by OCT4 and small molecules, we further applied the conditions to other human primary cell types, including HUVECs (differentiated mesoderm cells) and AFDCs (amniotic fluid derived cells).", "Similarly, TRA-1-81 positive iPSC colonies appeared in OCT4 infected HUVECs and AFDCs that were treated with chemicals.", "Remarkably, it appeared that reprogramming of HUVECs and AFDCs was more efficient and faster than reprogramming of NHEKs under the OCT4 and small molecule conditions (Table 4).", "Two clones of iPSCs from each cell type were long-term expanded for over 20 passages under conventional hESC culture condition and further characterized (Table 5).", "These stably expanded hiPSC-OK and hiPSC-O cells are morphologically indistinguishable to hESCs, and could be cultured on ECM-coated surface under feeder-free and chemically defined conditions (FIG.", "8e and FIG.", "13).", "They stained positive for alkaline phosphatase (ALP) and expressed typical pluripotency markers, including OCT4, SOX2, NANOG, TRA-1-81 and SSEA4, detected by immunocytochemistry/ICC (FIG.", "8e, 10b, FIGS.", "11-12).", "In addition, RT-PCR analysis confirmed the expression of the endogenous human OCT4, SOX2, NANOG, REX1, UTF1, TDGF2, FGF4 genes, and silencing of exogenous OCT4 and KLF4 (FIGS.", "9a and 10c).", "Furthermore, bisulfite sequencing analysis revealed that the OCT4 and NANOG promoters of hiPSC-OK and hiPSC-O cells are largely demethylated (FIGS.", "9b and 10d).", "This result provides further evidence for reactivation of the pluripotency transcription program in the hiPSC-OK and hiPSC-O cells.", "Global gene expression analysis of hiPSC-O cells, NHEKs and hESCs showed that hiPSC-O cells are distinct from NHEKs (Pearson correlation value: 0.87) and most similar to hESCs (Pearson correlation value: 0.98) (FIG.", "9c).", "Genetyping analysis showed that hiPSC-O cells only contained the OCT4 transgene without the contamination of transgene KLF4 or SOX2 (FIG.", "15).", "Southern blot analysis showed that there were multiple different integration sites of the OCT4 transgene (FIG.", "16) among different clones.", "In addition, karyotyping result demonstrated that hiPSC-O maintained normal karyotype during the whole reprogramming and expansion process (FIG.", "17).", "Furthermore, DNA fingerprinting test excluded the possibility that these hiPSCs arose from hESC contamination in the laboratory (Table 6).", "To examine the developmental potential of these hiPSC-O cells, they were differentiated in vitro by the standard embryoid body (EB) differentiation method.", "ICC analyses demonstrated that they could effectively differentiate into βIII-tubulin+ characteristic neuronal cells (ectoderm), SMA+ mesodermal cells, and AFP+ endodermal cells (FIGS.", "9d and 10e).", "Quantitative PCR analyses further confirmed the expression of these and additional lineage specific marker genes, including ectodermal cells (βIII-tubulin and NESTIN), mesodermal cells (MSX1 and MLC2a), and endodermal cells (FOXA2 and AFP) (FIG.", "9e).", "Following EB protocol, these hiPSC-OK and hiPSC-O cells could also give rise to rhythmically beating cardiomyocytes.", "To test their in vivo pluripotency, they were transplanted into SCID mice.", "Four-six weeks later, these hiPSC-O cells effectively generated typical teratomas containing derivatives of all three germ layers (FIGS.", "9f and 10f).", "Collectively, these in vitro and in vivo characterizations demonstrated that a single transcription factor, OCT4, combined with a defined small molecule cocktail is sufficient to reprogram several human primary somatic cells to iPSCs that are morphologically, molecularly and functionally similar to pluripotent hESCs.", "The studies presented above have a number of important implications: (1) Although fetal NSCs were shown to be reprogrammed to iPSCs by ectopic expression of Oct4 alone, there have been significant skepticisms around whether exogenous Oct4 gene alone would be sufficient to reprogram other more practical human somatic cells that do not endogenously express Sox2 (one of the two master pluripotency genes in reprogramming), are at later developmental stages (e.g.", "early embryonic/fetal vs. born/adult), and can be obtained without significant harms to the individual.", "To our knowledge, our study is the first demonstration that iPSCs can be practically derived from readily available primary human somatic cells (e.g.", "keratinocytes) transduced with a single exogenous reprogramming gene, Oct4.In contrast to neural stem cells from the brain, keratinocytes are more accessible and can be easily obtained from born individuals with less invasive procedures.", "This further strengthens the strategy of exploiting various practically accessible human somatic cells for iPSC generation with safer approaches and/or better qualities.", "Thus, this new method and its further development would significantly facilitate production of patient-specific pluripotent stem cells for various applications.", "(2) Although small molecules and their combinations have been identified to replace only one or two reprogramming TFs, it becomes exponentially challenging to generate iPSCs when more exogenous reprogramming TFs are omitted together.", "The identification of this new small molecule cocktail, which functionally re-places three master transcription factors all together (i.e.", "Sox2, Klf4 and cMyc) in enabling generation of iPSCs with Oct4 alone, represents another major step toward the ultimate reprogramming with only small molecules, and further proved and solidified the chemical approach to iPSCs.", "(3) This demonstrated single gene condition also has a significant implication for protein-induced pluripotent stem cell (piPSC) technology.", "A practical challenge for piPSC technology is large-scale and reliable production of the four transducible reprogramming proteins, each of which behaves differently in manufacture (e.g.", "their expression, folding, stability etc.).", "Clearly, combining this small molecule cocktail with a single transducible protein would significantly simplify the piPSC technology and facilitate its applications.", "(4) More significantly, we identified a new small molecule, PS48, with a new target/mechanism in enhancing reprogramming.", "PS48 is an allosteric small molecule activator of PDK1, which is an important upstream kinase for several AGC kinases, including Akt/PKB (Alessi et al., Curr Biol 7, 261-269 (1997)).", "Its reprogramming enhancing effect may be partly attributed to the activation of Akt/PKB, which promotes cell proliferation and survival (Manning, B. D., Cantley, L. C., Cell 129, 1261-1274 (2007)).", "Further in-depth characterizations on how PDK1-involved mechanisms are precisely regulated during reprogramming process should provide additional insights underlying reprogramming and pluripotency.", "Furthermore, because there might be even greater hidden risks (e.g.", "more subtle genetic and/or epigenetic abnormalities could be generated or selected during the reprogramming process) imposed by the low efficiency and slow kinetics of reprogramming, identification of new small molecules for enhancing reprogramming as illustrated again in this study would always be highly valuable toward a safer, easier and more efficient procedure for human iPSC generation.", "(5) Finally, this new and powerful small molecule cocktail for reprogramming validated the step-wise chemical optimization and screening strategy presented here as a productive approach toward the ultimate purely chemical-induced pluripotent stem cells.", "Moreover, the finding that different small molecules modulating the same target/mechanism could have significantly different effects on reprogramming in a different context, exemplified by A-83-01's and NaB's better reprogramming enhancing activities in human keratinocytes, suggests the importance of “individualized” optimization and treatment with different regimens for specific reprogramming context.", "Cell Culture Normal Human Epidermal Keratinocytes (Lonza) were maintained in Keratinocyte culturing medium (KCM, Lonza).", "Human Umbilical Vein Endothelial Cells (HUVECs, Millipore) were maintained in EndoGRO-VEGF Complete Medium (HCM, CHEMICON).", "Human ESCs and hiPSCs were cultured on MEF feeder cells in conventional human ESC culture media (hESCM: DMEM/F12, 15% Knockout serum replacement, 1% Glutamax, 1% Non-essential amino acids, 1% penicillin/streptomycin, 0.1 mM β-mercaptoethanol and 10 ng/ml bFGF).", "All cell culture products were from Invitrogen/Gibco BRL except where mentioned.", "Lentivirus Production The lentivirus supernatants were produced and harvested as previously described (Yu, J. et al., Science 318:1917-1920 (2007)).", "The plasmids used for lentivirus production include pSin-EF2-Puro-hOCT4, pSin2-EF2-Puro-hSOX2, pLove-mKlf4, pLove-mMyc, the packaging plasmid psPAX2 and the envelop-coding plasmid pMD2.G (Yu, J. et al., Science 318:1917-1920 (2007) and Li, W. et al., Stem Cells 27:2992-3000 (2009)).", "Reprogramming of NHEKs NHEKs were cultured in a 100 mm tissue culture dish and transduced 3 times (3-4 hours each transduction) with freshly produced lentivirus supernatants.", "1,000,000 transduced NHEKs were seeded on the irradiated x-ray inactivated CF1 MEF feeder cells in a 100-mm dish and cultured in KCM and treated with 5 μM PS48, 0.25 mM NaB (Stemgent) and 0.5 μM A-83-01 (Stemgent) for 2 weeks, followed by changing half volume of media to hESCM and supplementing with 5 μM PS48, 0.25 mM NaB and 0.5 μM A-83-01 for another 2 weeks.", "Then cell culture media were changed to hESCM and supplemented with 5 μM PS48, 0.25 mM NaB, 0.5 μM A-83-01 and 0.5 μM PD0325901 (Stemgent) for additional four weeks.", "The same OCT4 infected keratinocytes cultured in media without chemicals were used as a control.", "The culture was split by Accutase (Millipore) and treated with 1 μM Thiazovivin (Stemgent) in the first day after splitting.", "The iPSC colonies stained positive by Alexa Fluor 555 Mouse anti-Human TRA-1-81 antibody (BD Pharmingen) were picked up for expansion on feeder cells in hESCM and cultured routinely.", "Reprogramming of HUVECs HUVECs were cultured in a 100 mm tissue culture dish and transduced 2 times (4-6 hours each transduction) with freshly produced lentivirus supernatants.", "200,000 transduced HUVECs were seeded on gelatin coated 100-mm dish, cultured in HCM, and treated with 5 μM PS48, 0.25 mM NaB and 0.5 μM A-83-01 for 2 weeks, followed by changing half volume of media to hESCM and supplementing with 5 μM PS48, 0.25 mM NaB and 0.5 μM A-83-01 for another 2 weeks.", "Then cell culture media were changed to hESCM and supplemented with 5 μM PS48, 0.25 mM NaB, 0.5 μM A-83-01 and 0.5 μM PD0325901 for additional 1-2 weeks.", "The iPSC colonies stained positive by Alexa Fluor 555 Mouse anti-Human TRA-1-81 antibody were picked up for expansion on feeder cells in hESCM and cultured routinely.", "The culture was split by Accutase and treated with 1 μM Thiazovivin in the first day after splitting.", "In Vitro Differentiation The in vitro differentiation of hiPSCs was carried out by the standard embryoid body (EB) method.", "Briefly, the hiPSCs were dissociated by Accutase (Millipore), cultured in ultra-low attachment 6-well plate for eight days and then transferred to Matrigel-coated 6-well plate in differentiation medium.", "The cells were fixed for immunocytochemical analysis or harvested for RT-PCR tests eight days later.", "Differentiation medium: DMEM/F12, 10% FBS, 1% Glutamax, 1% Non-essential amino acids, 1% penicillin/streptomycin, 0.1 mM (3-mercaptoethanol.", "Alkaline Phosphatase Staining and Immunocytochemistry Assay Alkaline Phosphatase staining was performed according to the manufacturer's protocol using the Alkaline Phosphatase Detection Kit (Stemgent).", "Standard immunocytochemistry assay was carried out as previously reported (Li, W. et al., Stem Cells 27:2992-3000 (2009)).", "Primary antibodies used can be found in the Table 3.Secondary antibodies were Alexa Fluor 488 donkey anti-mouse or anti-rabbit IgG (1:1000) (Invitrogen).", "Nuclei were visualized by DAPI (Sigma-Aldrich) staining.", "Images were captured using a Nikon Eclipse TE2000-U microscope.", "Gene Expression Analysis by RT-PCR and qRT-PCR For RT-PCR and qRT-PCR analysis, total RNA was extracted from human iPSCs using the RNeasy Plus Mini Kit in combination with QIAshredder (Qiagen).", "First strand reverse transcription was performed with 2 μg RNA using iScript′ cDNA Synthesis Kit (BioRad).", "The expression of pluripotency markers was analyzed by RT-PCR using Platinum PCR SuperMix (Invitrogen).", "The expression of lineage specific markers after differentiation was analyzed by qRT-PCR using iQ SYBR Green Supermix (Bio-Rad).", "The primers can be found in the Table 2.Microarray Analysis The Human Ref-8_v3 expression Beadchip (Illumina, Calif., USA) was used for microarray hybridizations to examine the global gene expression of NHEKs, hiPSC and hES cells.", "Biotin-16-UTP-labeled cRNA was synthesized from 500 ng total RNA with the Illumina TotalPrep RNA amplification kit (Ambion AMIL1791, Foster City, Calif., USA).", "The hybridization mix containing 750 ng of labeled amplified cRNA was prepared according to the Illumina BeadStation 500× System Manual (Illumina, San Diego, Calif., USA) using the supplied reagents and GE Healthcare Streptavidin-Cy3 staining solution.", "Hybridization to the Illumina Human Ref-8 v3 expression Beadchip was for 18 h at 55° C. on a BeadChip Hyb Wheel.", "The array was scanned using the Illumina BeadArray Reader.", "All samples were prepared in two biological replicates.", "Processing and analysis of the microarray data were performed with the Illumina BeadStudio software.", "The data were subtracted for background and normalized using the rank invariant option.", "Bisulfate Genomic Sequencing Genomic DNAs were isolated using the Non Organic DNA Isolation Kit (Millipore) and then treated with the EZ DNA Methylation-Gold Kit (Zymo Research Corp., Orange, Calif.).", "The treated DNAs were then used as templates to amplify sequences of interest.", "Primers used for OCT4 and NANOG promoter fragment amplification are indicated in Table 2.The resulting fragments were cloned using the TOPO TA Cloning Kit for sequencing (Invitrogen) and sequenced.", "Genotyping of hiPSCs Genotyping of hiPSC lines was performed using RT-PCR of genomic DNA with specific primers (Table 2; Yu, J. et al., Science 318:1917-1920 (2007) and Li, W. et al., Stem Cells 27:2992-3000 (2009)).", "Teratoma Formation The hiPSC lines were harvested by using 0.05% Trypsin-EDTA.", "Five million cells were injected under the kidney capsule of SCID mice (n=3).", "After 4-6 weeks, well developed teratomas were harvested, fixed and then histologically analyzed at TSRI histology core facility.", "TABLE 2 Primers used Gene Forward (SEQ ID NO:) Reverse (SEQ ID NO:) For RT-PCR Endo-OCT4 AGTTTGTGCCAGGGTTTTTG (1) ACTTCACCTTCCCTCCAACC (2) Endo-SOX2 CAAAAATGGCCATGCAGGTT (3) AGTTGGGATCGAACAAAAGCTATT (4) Endo-NANOG TTTGGAAGCTGCTGGGGAAG (5) GATGGGAGGAGGGGAGAGGA (6) Endo-KLF4 ACGATCGTGGCCCCGGAAAAGGACC (7) GATTGTAGTGCTTTCTGGCTGGGCTCC (8) Endo-cMYC GCGTCCTGGGAAGGGAGATCCGGAGC (9) TTGAGGGGCATCGTCGCGGGAGGCTG (10) REX1 CAGATCCTAAACAGCTCGCAGAAT (11) GCGTACGCAAATTAAAGTCCAGA (12) UTF1 CCGTCGCTGAACACCGCCCTGCTG (13) CGCGCTGCCCAGAATGAAGCCCAC (14) TDGF2 CTGCTGCCTGAATGGGGGAACCTGC (15) GCCACGAGGTGCTCATCCATCACAAGG (16) FGF4 CTACAACGCCTACGAGTCCTACA (17) GTTGCACCAGAAAAGTCAGAGTTG (18) Exo-OCT4 TGTCTCCGTCACCACTCTGG (19) ATGCATGCGGATCCTTCG (20) PAX6 TGTCCAACGGATGTGAGT (21) TTTCCCAAGCAAAGATGGAC (22) βIII CAACAGCACGGCCATCCAGG (23) CTTGGGGCCCTGGGCCTCCGA (24) TUBULIN FOXF1 AAAGGAGCCACGAAGCAAGC (25) AGGCTGAAGCGAAGGAAGAGG (26) HAND1 TCCCTTTTCCGCTTGCTCTC (27) CATCGCCTACCTGATGGACG (28) AFP AGCAGCTTGGTGGTGGATGA (29) CCTGAGCTTGGCACAGATCCT (30) GATA6 TGTGCGTTCATGGAGAAGATCA (31) TTTGATAAGAGACCTCATGAACCGACT (32) GAPDH GTGGACCTGACCTGCCGTCT (33) GGAGGAGTGGGTGTCGCTGT (34) For bisulfate-sequencing OCT4-1 TTAGGAAAATGGGTAGTAGGGATTT (35) TACCCAAAAAACAAATAAATTATAAAACCT (36) OCT4-2 GGATGTTATTAAGATGAAGATAGTTGG (37) CCTAAACTCCCCTTCAAAATCTATT (38) NANOG GAGTTAAAGAGTTTTGTTTTTAAAAATTAT TCCCAAATCTAATAATTTATCATATCTTTC (40) (39) For genotyping OCT4-Int CAGTGCCCGAAACCCACAC (41) AGAGGAACTGCTTCCTTCACGACA (42) SOX2-Int TACCTCTTCCTCCCACTCCA (43) AGAGGAACTGCTTCCTTCACGACA (44) KLF4-Int CACCTTGCCTTACACATGAAGAGG (45) CGTAGAATCGAGACCGAGGAGA (46) TABLE 3 Primary antibodies applied Antibody Species Dilution Vendor Anti-OCT4 (1) Mouse 1:500 Santa Cruz Biotechnology Anti-OCT4 (2) Rabbit 1:500 Stemgent Anti-SOX2 Rabbit 1:1000 Chemicon Anti-NANOG Rabbit 1:500 Abcam Anti-SSEA4 Mouse 1:500 Stemgent Anti-TRA-1-81 Mouse 1:500 Stemgent TUJ1 (Anti-βIII Mouse 1:3000 Covance Research Products TUBULIN) Anti-SMA Mouse 1:500 Sigma Anti-AFP Mouse 1:500 Sigma TABLE 4 Summary of reprogramming experiments TRA-1-81 positive Donor Cells Induction factors Chemicals Experiments colonies NHEKs OCT4 + KLF4 + SOX2 + MYC DMSO #1 17 (lot number: #2 20 0000087940) #3 23 A83 + PD #1 72 #2 104 #3 91 OCT4 + KLF4 + SOX2 DMSO #1 2 #2 3 #3 8 A83 + PD #1 26 #2 35 #3 44 A83 + PD #1 1 #2 2 #3 0 A83 + PS48 + PD #1 15 #2 18 #3 5 OCT4 + KLF4 A83 + VPA + PD #1 6 #2 0 #3 3 A83 + NaB + PD #1 20 #2 17 #3 18 A83 + PS48 + NaB + PD #1 21 #2 30 #3 27 OCT4 A83 + PS48 + NaB + PD #1 4 #2 0 #3 3 NHEKs OCT4 A83 + PS48 + NaB + PD #1 2 (lot number: #2 3 2F0661) #3 0 AHEKs OCT4 A83 + PS48 + NaB + PD + #1 3 Par + CHIR #2 2 HUVECs OCT4 A83 + PS48 + NaB + PD #1 4 #2 7 #3 4 HUVECs OCT4 A83 + PS48 + NaB + PD + #1 23 Par + CHIR #2 17 AFDCs OCT4 A83 + PS48 + NaB + PD + #1 5 Par + CHIR #2 11 NHEKs, Neonatal Human Epidermal Keratinocytes; HUVECs, Human Umbilical Vein Endothelial Cells; AHEKs, Adult Human Epidermal Keratinocytes; AFDCs, Amniotic Fluid Derived Cells.", "Chemical concentration used: PD, 0.5 μM PD0325901; A83, 0.5 μM A-83-01; PS48, 5 μM PS48; VPA, 0.5 mM Valproic acid; NaB, 0.25 mM Sodium butyrate; Par, 2 μM Parnate; CHIR, 3 μM CHIR99021.For four-factor or three-factor induced reprogramming, NHEKs were seeded at a density of 100,000 transduced cells per 10 cm dish and positive colonies were counted four-week later; For two-factor induced reprogramming, NHEKs were seeded at a density of 100,000 transduced cells per 10 cm dish and positive colonies were counted six-week later; For one-factor induced reprogramming, NHEKs and AHEKs were seeded at a density of 1,000,000 transduced cells per 10 cm dish and positive colonies were counted eight-week later; HUVECs and AFDCs were seeded at a density of 200,000 transduced cells per 10 cm dish and positive colonies were counted six-week later.", "TABLE 5 Characterization of established human iPSC cell lines Induction Cell Marker RT-PCR EB Teratoma hiPSC clone factors source expression test differentiation test hiPSC-OK#1 OCT4 + KLF4 NHEKs ✓ ✓ ✓ ✓ hiPSC-OK#3 ✓ ✓ ✓ hiPSC-O#1 OCT4 NHEKs ✓ ✓ ✓ ✓ hiPSC-O#3 ✓ ✓ ✓ hiPSC-O#4 ✓ hiPSC-O#5 ✓ 2 more lines hiPSC-O#21 OCT4 HUVECs ✓ ✓ ✓ ✓ hiPSC-P#22 ✓ hiPSC-O#26 ✓ ✓ ✓ hiPSC-O#31 ✓ ✓ ✓ ✓ 7 more lines hiPSC-O#52 OCT4 AHEKs ✓ ✓ hiPSC-O#57 ✓ hiPSC-O#63 OCT4 AFDCs ✓ ✓ hiPSC-O#65 ✓ Those cell lines characterized were long-term expanded for over 20 passages under conventional hESC culture condition and further characterized for marker expression and pluripotency; while other cell lines established were stored at passage 5 or 6.Blank entries indicate not determined.", "TABLE 6 DNA fingerprint analysis on Oct4 induced iPSCs and parental cell lines Genomic hiPSC- hiPSC- loci NHEK (pooled) O#1 HUVEC O#21 Amelogenin X, Y X, Y X X vWA 11, 15, 17, 18, 19 15, 18 15; 16 15; 16 D8S1179 10, 13, 16 13, 10; 13 10; 13 TPOX 8, 9, 11, 12 8 8 8 FGA 19, 22, 23, 24 19, 22 24; 27 24; 27 D3S1358 13, 14, 15, 17 17 14; 16 14; 16 THO1 6, 7, 9, 9.3 7, 9 6 6 D21S11 24.2, 29, 30.2, 35 24.2, 29 28; 30.2 28; 30.2 D18S51 13, 14, 16, 17, 18, 19 13, 17 13; 18 13; 18 Penta E 5, 8, 13, 14, 19 13, 19 12 12 D5S818 8, 11, 12, 13 11, 13 12; 13 12; 13 D13S317 8, 9, 11, 12, 13 9, 12 11; 14 11; 14 D7S820 8, 9, 10, 11 9, 10 11 11 D16S539 9, 10, 11, 12, 13 9, 13 9; 11 9; 11 CSF1PO 10, 11, 12 11, 12 11; 12 11; 12 Penta D 2.2, 10, 12 10 12; 13 12; 13 Fifteen polymorphic short tandem repeat (STR) DNA loci and the sex chromosome marker amelogenin were investigated.", "It is understood that the examples and embodiments described herein are for illustrative purposes only and that various modifications or changes in light thereof will be suggested to persons skilled in the art and are to be included within the spirit and purview of this application and scope of the appended claims.", "All publications, patents, and patent applications cited herein are hereby incorporated by reference in their entirety for all purposes." ] ]
Patent_15875928
[ [ "SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B", "Inhibitors of HBV replication of Formula (ID) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, Ra to Rd and R4 to R6 have the meaning as defined herein.", "The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy." ], [ "1-15.", "(canceled) 16.A method of treating HBV infection in a subject in need thereof comprising administering to said subject a therapeutically effective amount of a compound of Formula (ID) or a stereoisomer or tautomeric form thereof, wherein: each X is independently CR7; Ra, Rb and Rc are each independently selected from the group consisting of hydrogen, fluoro, bromo, chloro, —CHF2, —CF2-methyl, —CH2F, —CF3, —OCF3, —CN, C1-C3alkyl and C3-C4cycloalkyl; Rd is hydrogen or fluoro; R4 is hydrogen, C1-C3alkyl or C3-C4cycloalkyl; R5 is hydrogen; R6 is selected from the group consisting of C2-C6alkyl, C1-C4alkyl-R8 optionally substituted with one or more fluoro, C1-C4alkyl-R9 optionally substituted with one or more fluoro, and a 3-7 membered mono or polycyclic saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or C2-C6alkyl optionally substituted with one or more substituents each independently selected from the group consisting of hydrogen, —OH, fluoro, oxo, R9, R10 and C1-C4alkyl optionally substituted with R10; R7 is selected from the group consisting of hydrogen, —CN, fluoro, chloro, bromo, —CHF2, —CF2-methyl, —CH2F, —CF), C1-C3alkyl optionally substituted with methoxy, C2-C3alkenyl and C3-C4cycloalkyl; R8 is a 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring optionally substituted with one or more C1-C4alkyl optionally substituted with R10; R9 is selected from the group consisting of C1-C4alkyloxy, —SO2-methyl, —C(═O)—OR11 and —C(═O)—N(R11)2; R10 is selected from the group consisting of —CN, —OH, fluoro, —CHF2, —CH2F and —CF3; R11 is hydrogen or C1-C3alkyl; or a pharmaceutically acceptable salt or a solvate thereof wherein such compound is not 17.The method of claim 16, wherein Ra is —CN; Rb, Rc and Rd are each independently selected from the group consisting of hydrogen and fluoro; R4 is C1-C3alkyl; R6 is selected from the group consisting of C2-C6alkyl, optionally substituted with one or more fluoro; and R7 is hydrogen.", "18.The method of claim 16, wherein the compound is selected from the group consisting of: N-(4-fluoro-3-methyl-phenyl)-4-(isopropylsulfamoyl)-1H-pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-4-[[(1R)-2-hydroxy-1-methyl-ethyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(1R)-1-methylpropyl]sulfamoyl]pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)methylsulfamoyl]pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-4-[[3-(hydroxymethyl)oxetan-3-yl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[(3-methyltetrahydrofuran-3-yl)sulfamoyl]pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-4-[[1-(hydroxymethyl)cyclopropyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[(1-methyl-5-oxo-pyrrolidin-3-yl)sulfamoyl]pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-4-[[3-(2-hydroxyethyl)oxetan-3-yl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-4-[(3-hydroxycyclobutyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide; 4-(tert-butylsulfamoyl)-N-(4-fluoro-3-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide 4-[[3-(cyanomethyl)oxetan-3-yl]sulfamoyl]-N-(4-fluoro-3-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide; 4-[[1-(cyanomethyl)cyclopropyl]sulfamoyl]-N-(4-fluoro-3-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide; 4-(tert-butylsulfamoyl)-N-(3,4-difluorophenyl)-1-methyl-pyrrole-2-carboxamide; N-(3,4-difluorophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide; N-(3,4-difluorophenyl)-1-methyl-4-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]pyrrole-2-carboxamide; N-(3,4-difluorophenyl)-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide; N-(3,4-difluorophenyl)-1-methyl-4-[[1R)-1-methyl propyl]sulfamoyl]pyrrole-2-carboxamide; N-(3,4-difluorophenyl)-4-[[(1R)-2-hydroxy-1-methyl-ethyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-(3,4-difluorophenyl)-4-[(3-hydroxycyclobutyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide; 1-methyl-4-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]-N-(3,4,5-trifluorophenyl)pyrrole-2-carboxamide; 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-N-(3,4,5-trifluorophenyl)pyrrole-2-carboxamide; 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-N-[3-(trifluoromethyl)phenyl]pyrrole-2-carboxamide; 1-ethyl-N-(4-fluoro-3-methyl-phenyl)-4-(isopropylsulfamoyl)pyrrole-2-carboxamide; 1-ethyl-N-(4-fluoro-3-methyl-phenyl)-4-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]pyrrole-2-carboxamide; N-(4-fluoro-3,5-dimethyl-phenyl)-1-methyl-4-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]pyrrole-2-carboxamide; N-(3-fluoro-5-methyl-phenyl)-1-methyl-4-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]pyrrole-2-carboxamide; N-(3,4-difluoro-5-methyl-phenyl)-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide; N-(3,4-difluoro-5-methyl-phenyl)-1-methyl-4-[[(1R)-1-methyl propyl]sulfamoyl]pyrrole-2-carboxamide; N-(3,4-difluoro-5-methyl-phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide; N-(3,4-difluoro-5-methyl-phenyl)-4-[[(1R)-2-hydroxy-1-methyl-ethyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-(3,4-difluoro-5-methyl-phenyl)-1-methyl-4-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]pyrrole-2-carboxamide; 4-(tert-butylsulfamoyl)-N-(3,4-difluoro-5-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide; N-[3-(difluoromethyl)-4-fluoro-phenyl]-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide; N-[3-(difluoromethyl)-4-fluoro-phenyl]-4-[[(1R)-2-hydroxy-1-methyl-ethyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-[4-fluoro-3-(trifluoromethyl)phenyl]-4-[[(1R)-2-hydroxy-1-methyl-ethyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-4-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]pyrrole-2-carboxamide; N-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide; N-[4-fluoro-3-(trifluoromethyl)phenyl]-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide; N-[3-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide; N-(3-bromo-4,5-difluoro-phenyl)-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide; N-(3-bromo-4,5-difluoro-phenyl)-1-methyl-4-[[(1R)-1-methylpropyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-bromo-4,5-difluoro-phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide; methyl 2-[[5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrol-3-yl]sulfonylamino]-2-methyl-propanoate; N-(3-cyano-4-fluorophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-[4-cyano-3-(trifluoromethyl)phenyl]-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-cyano-4,5-difluoro-phenyl)-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide; 4-(tert-butylsulfamoyl)-N-(3-cyano-5-fluoro-phenyl)-1-methyl-pyrrole-2-carboxamide; N-(3-cyano-5-fluoro-phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide; N-(3-cyanophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide; N-(2,6-dideuterio-4-fluoro-3-methyl-phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide; N-(3-chloro-4,5-difluoro-phenyl)-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide; 4-(tert-butylsulfamoyl)-N-(3-chloro-4,5-difluoro-phenyl)-1-methyl-pyrrole-2-carboxamide; N-(3-chloro-4,5-difluoro-phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide; N-(3-chloro-4,5-difluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 2-[[5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrol-3-yl]sulfonylamino]-2-methyl-propanoic acid; 4-[[1,1-dimethyl-2-(methylamino)-2-oxo-ethyl]sulfamoyl]-N-(4-fluoro-3-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide; 4-[[2-(dimethylamino)-1,1-dimethyl-2-oxo-ethyl]sulfamoyl]-N-(4-fluoro-3-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide; 4-[(2-amino-1,1-dimethyl-2-oxo-ethyl)sulfamoyl]-N-(4-fluoro-3-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide; N-(3-chloro-4,5-difluoro-phenyl)-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-(3-chloro-4,5-difluoro-phenyl)-4-(1,1-dimethylpropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide; 4-(tert-butylsulfamoyl)-N-(2,6-dideuterio-4-fluoro-3-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide; 4-(tert-butylsulfamoyl)-1-methyl-N-(3,4,5-trifluorophenyl)pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[2,2,2-trideuterio-1,1-bis(trideuteriomethyl)ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(2,6-dideuterio-4-fluoro-3-methyl-phenyl)-1-methyl-4-[[2,2,2-trideuterio-1,1-bis(trideuteriomethyl)ethyl]sulfamoyl]pyrrole-2-carboxamide; 4-(tert-butylsulfamoyl)-N-(2,6-dideuterio-3,4,5-trifluoro-phenyl)-1-methyl-pyrrole-2-carboxamide; N-(3-chloro-4,5-difluoro-phenyl)-1-methyl-4-[[1-(trifluoromethyl)cyclopropyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-chloro-4,5-difluoro-phenyl)-1-methyl-4-[[2,2,2-trifluoro-1-(methoxymethyl)-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3,4-difluorophenyl)-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide; N-(3,5-Dichloro-4-fluorophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-N-(3,5-dichloro-4-fluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide; N-(4-Chloro-3-methyl phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-[4-Fluoro-3-methyl-5-(trifluoromethyl)phenyl]-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(4-Fluoro-3,5-dimethylphenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Bromo-4-fluorophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; 1-Methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-N-[3-methyl-5-(trifluoromethyl)phenyl]-1H-pyrrole-2-carboxamide; N-(4-Cyano-3-methyl phenyl)-1-methyl-4-[(3-methyloxetan-3-ylsulfamoyl]-1H-pyrrole-2-carboxamide; N-(4-Chloro-3-fluorophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(2,4-Difluoro-3-methyl phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-[4-Fluoro-3-(trifluoromethoxy)phenyl]-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-5-cyanophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(4-Fluoro-3-methyl phenyl)-1,3,5-trimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(4-Fluoro-3-methyl phenyl)-1,5-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(4-Fluoro-3-methyl phenyl)-1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1-methyl-4-[(3-methyltetrahydrofuran-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1-methyl-4-{[1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Fluoro-N-(4-fluoro-3-methylphenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(4-Fluoro-3-methylphenyl)-1-methyl-4-{[(1R)-1-methyl-2-(methylsulfonyl)ethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-N-[4-fluoro-3-(trifluoromethoxy)phenyl]-1-methyl-1H-pyrrole-2-carboxamide; N-(2,4-Difluoro-3-methylphenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Bromo-4,5-difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Bromo-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluoro-5-methyl phenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Bromo-4-fluorophenyl)-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-[3-(Difluoromethyl)-4-fluorophenyl]-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; 3-Fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-N-(2,4,5-trifluorophenyl)-1H-pyrrole-2-carboxamide; N-(2,4-Difluoro-3-methylphenyl)-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; 4-(tert-butylsulfamoyl)-N-(2,4-difluoro-3-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide; 4-[(1-Carbamoylcyclopropypsulfamoyl]-N-(3-chloro-4,5-difluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-{[1-(methylcarbamoyl)cyclopropyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(2,4-Difluoro-3-methyl phenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(2,4-Difluoro-3-methyl phenyl)-1-methyl-4-{[1-(trifluoromethyl)cyclopropyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(2,4-Difluoro-3-methyl phenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(2,4-Difluoro-3-methyl phenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; 1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]-N-[3-(trifluoromethyl)phenyl]pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Bromo-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-4-[(2,2-difluoroethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide; N-(3-Bromo-4-fluorophenyl)-4-[(2,2-difluoroethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-4-[(2,2-difluoroethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide; 4-[(2,2-Difluoroethyl)sulfamoyl]-N-(3,4-difluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-4-[(2,2-difluoroethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoroethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1-methyl-4-[(2,2,2-trifluoroethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-[(2,2,2-trifluoroethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoroethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Bromo-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoroethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-1,5-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Bromo-4-fluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-[4-Fluoro-3-(trifluoromethyl)phenyl]-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1,3-dimethyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1,3-dimethyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1,3-dimethyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-[4-Fluoro-3-(trifluoromethyl)phenyl]-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 1-Methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-N-(2,3,4-trifluorophenyl)-1H-pyrrole-2-carboxamide; N-(3-Bromo-2,4-difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-Cyanophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-[2-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-2-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-[3-(1,1-Difluoroethyl)-4-fluorophenyl]-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-N-[3-(1,1-difluoroethyl)-4-fluorophenyl]-1-methyl-1H-pyrrole-2-carboxamide; N-(3,5-Dichloro-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-4-[(3,3-difluorocyclobutyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide; N-(3-chloro-4,5-difluoro-phenyl)-1-methyl-4-[[1-methyl-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-4-[(3,3-difluorocyclopentyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide; 4-(Bicyclo[1.1.1]pent-1-ylsulfamoyl)-N-(3-chloro-4,5-difluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-[(3,3,3-trifluoropropyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-[(3,3,3-trifluoro-1-methyl propyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-3-fluoro-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-2-fluorophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Cyano-2-fluorophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Cyanophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Cyano-2,4-difluorophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-[4-Fluoro-3-(trifluoromethyl)phenyl]-1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Cyanophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-2,4-difluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-2-fluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-N-(2,3,4-trifluorophenyl)-1H-pyrrole-2-carboxamide; N-(3-Bromo-2,4-difluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-1-methylpropyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-4-[(3,3-difluoro-1-methylcyclobutyl)sulfamoyl]-3-fluoro-1-methyl-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-3-fluoro-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-{[1-(trifluoromethyl)cyclobutyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-N-(3-cyano-4-fluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-N-(3-cyanophenyl)-1-methyl-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-N-(3-cyano-2-fluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-N-(3-chloro-2-fluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-N-(3-chloro-2,4-difluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-N-(3-chloro-4-fluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide; N-(3-Cyano-2,4-difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyanophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-2-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-4-{[2,2-difluoro-1-methylethyl]sulfamoyl}-1-methyl-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(2,3-Difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,6-difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Bromo-4,5-difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Bromo-2-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-chloro-4,5-difluoro-phenyl)-4-[(2-fluoro-1,1-dimethyl-ethyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-1,3-dimethyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-1,3-dimethyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-N-(3,4-difluorophenyl)-3-fluoro-1-methyl-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-N-(3-chloro-2,4-difluorophenyl)-3-fluoro-1-methyl-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-3-fluoro-1-methyl-N-(2,3,4-trifluorophenyl)-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-N-(3-cyano-4-fluorophenyl)-3-fluoro-1-methyl-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; 3-Cyano-N-(3-cyano-4-fluorophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3,4-difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-chloro-2,4-difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-chloro-2,4-difluorophenyl)-1-methyl-4-{[1-(trifluoromethyl)cyclobutyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-3-chloro-N-(3-chloro-4-fluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-{[1-(trifluoromethyl)cyclobutyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-chloro-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-3-chloro-N-(3,4-difluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-3-chloro-N-(3-chloro-2,4-difluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 4-(tert-Butylsulfamoyl)-3-chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[1-(trifluoromethyl)cyclopropyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[3-(trifluoromethyl)tetrahydrofuran-3-yl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Bromo-4-fluorophenyl)-3-fluoro-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Cyano-2,4-difluorophenyl)-3-fluoro-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-3-fluoro-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; 3-Fluoro-1-methyl-4-[(1-methylethyl)sulfamoyl]-N-(2,3,4-trifluorophenyl)-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-3-fluoro-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-3-fluoro-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-4-{[2,2-difluorocyclopentyl]sulfamoyl}-1-methyl-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-[(3,3,3-trifluoro-1-methyl propyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[(1S)-1-(trifluoromethyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[(1R)-1-(trifluoromethyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[1-(trifluoromethyl)cyclobutyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-4-{[2-fluoro-1-(fluoromethyl)ethyl]sulfamoyl}-1-methyl-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[(1-methylcyclopropyl)sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-{[1-methyl-1-(trifluoromethyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-{[4-(trifluoromethyl)tetrahydropyran-4-yl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-{[1-ethyl-1-(trifluoromethyl)propyl]sulfamoyl}-1-methyl-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[(2-fluoro-1,1-dimethyl-ethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide; N-(3-Bromophenyl)-3-chloro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Bromophenyl)-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-4-[(2,2-difluoro-1-methyl-ethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-{[1-(trifluoromethyl)cyclopropyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethyl-ethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-[(1-methylcyclopropyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-{[1-methyl-1-(trifluoromethyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-[[4-(trifluoromethyl)tetrahydropyran-4-yl]sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-4-[[1-ethyl-1-(trifluoromethyl)propyl]sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-[(3,3,3-trifluoro-1-methyl propyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-4-[(2-fluoro-1,1-dimethyl-ethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-{[(1S)-1-(trifluoromethyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-{[1-(trifluoromethyl)cyclobutyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-4-{[2-fluoro-1-(fluoromethyl)ethyl]sulfamoyl}-1-methyl-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-{[(1R)-1-(trifluoromethyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-{[3-(trifluoromethyl)tetrahydrofuran-3-yl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-chloro-N-(3,4-difluorophenyl)-1-methyl-4-{[1-(trifluoromethyl)cyclobutyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-chloro-N-(3-chloro-4-fluoro-phenyl)-1-methyl-4-{[1-(trifluoromethyl)cyclobutyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-{[1-(trifluoromethyl)cyclopropyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-chloro-N-(2-cyano-4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(2-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(2-fluoro-6-methyl-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-2,4-difluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(2,3-dichloro-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-[3-(difluoromethyl)-2,4-difluoro-phenyl]-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-[3-(difluoromethyl)-4-fluoro-phenyl]-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-bromophenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-[[1-(trifluoro-methyl)cyclopentyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-5-methyl-phenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[(1S)-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide; 3-fluoro-N-(4-fluorophenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-[3-(difluoromethyl)-4-fluoro-phenyl]-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-[3-(difluoromethyl)-2,4-difluoro-phenyl]-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[(1R)-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1S)-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-isopropyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-bromo-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-cyano-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-1-methyl propyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-1-methyl propyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[(3-hydroxy-1,1-dimethyl-propyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[[(1S)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1, 5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 5-bromo-3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 5-bromo-N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-4-fluoro-phenyl)-5-cyclopropyl-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-3-isopropyl-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-5-cyclopropyl-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-cyclopropyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-4-fluoro-phenyl)-4-(cyclopentylsulfamoyl)-1-methyl-pyrrole-2-carboxamide; 3-bromo-N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-3-fluoro-5-(methoxymethyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 5-cyano-N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]-5-vinyl-pyrrole-2-carboxamide; N-(2,4-difluorophenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-chloro-5-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 5-chloro-N-(3-cyano-2,4-difluoro-phenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 5-bromo-N-(3-cyano-2,4-difluoro-phenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-cyano-N-(3-cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[[(1S)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide; and N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide.", "19.The method of claim 16, wherein the compound is selected from the group consisting of: N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide′ N-(3,4-Difluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Bromo-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Bromo-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[(1S)-1-(trifluoromethyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[(1R)-1-(trifluoromethyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-{[1-methyl-1-(trifluoromethyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-{[1-ethyl-1-(trifluoromethyl)propyl]sulfamoyl}-1-methyl-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[(2-fluoro-1,1-dimethyl-ethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[[(1S)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Bromo-4-fluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1,3-dimethyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1,3-dimethyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1,3-dimethyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-2-fluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-3-fluoro-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3,4-difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-chloro-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; 3-chloro-N-[3-(difluoromethyl)-4-fluoro-phenyl]-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[(1S)-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide; N-[3-(difluoromethyl)-4-fluoro-phenyl]-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[(1R)-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1S)-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide; 3-bromo-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1, 5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[[(1S)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide; N-(3-chloro-4,5-difluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Bromo-4,5-difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluoro-5-methyl phenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4,5-difluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyanophenyl)-3-fluoro-1-methyl-4-{[1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-2,4-difluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-N-(2,3,4-trifluorophenyl)-1H-pyrrole-2-carboxamide; N-(3-Bromo-2,4-difluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-2,4-difluorophenyl)-3-fluoro-1-methyl-4-{[1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-2,4-difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-chloro-2,4-difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide N-(3-Bromophenyl)-3-chloro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethyl-ethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-{[(1R)-1-(trifluoromethyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-2,4-difluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-[3-(difluoromethyl)-2,4-difluoro-phenyl]-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-bromophenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-fluoro-N-(4-fluorophenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; and N-[3-(difluoromethyl)-2,4-difluoro-phenyl]-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide.", "20.The method of claim 16, wherein the compound is selected from the group consisting of: N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Bromo-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Bromo-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[(1S)-1-(trifluoromethyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[(1R)-1-(trifluoromethyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-{[1-methyl-1-(trifluoromethyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-{[1-ethyl-1-(trifluoromethyl)propyl]sulfamoyl}-1-methyl-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[(2-fluoro-1,1-dimethyl-ethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[[(1S)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Bromo-4-fluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1,3-dimethyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1,3-dimethyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1,3-dimethyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-2-fluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-3-fluoro-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3,4-difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-chloro-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; 3-chloro-N-[3-(difluoromethyl)-4-fluoro-phenyl]-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[(1S)-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide; N-[3-(difluoromethyl)-4-fluoro-phenyl]-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[(1R)-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1S)-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide; 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide; 3-bromo-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide; and N-(3-cyano-4-fluoro-phenyl)-4-[[(1S)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide.", "21.The method of claim 16, wherein the compound is selected from the group consisting of: N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3,4-Difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide′ N-(3,4-Difluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Bromo-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Chloro-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Bromo-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[(1S)-1-(trifluoromethyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[(1R)-1-(trifluoromethyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-{[1-methyl-1-(trifluoromethyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-{[1-ethyl-1-(trifluoromethyl)propyl]sulfamoyl}-1-methyl-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[(2-fluoro-1,1-dimethyl-ethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide; N-(3-cyano-4-fluoro-phenyl)-4-[[(1S)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide; and N-(3-cyano-4-fluoro-phenyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide.", "22.The method of claim 16, wherein the method of treating HBV infection prevents or treats conditions associated with HBV infection.", "23.The method of claim 22, wherein the conditions associated with HBV infection are selected from the group consisting of liver fibrosis, liver inflammation, liver necrosis, cirrhosis, end-stage liver disease, and hepatocellular carcinoma.", "24.The method of claim 16, further comprising administering an effective amount of at least one additional therapeutic agent.", "25.The method of claim 24, wherein the at least one additional therapeutic agent is an anti-HBV agent.", "26.The method of claim 24, wherein the at least one additional therapeutic agent is an immunomodulator.", "27.The method of claim 26, wherein the immunomodulator is an interferon or Toll-like receptor agonist.", "28.The method of claim 24, wherein the at least one additional therapeutic agent is selected from the group consisting of pegylated interferon-α, Toll-like receptor 7 and/or 8 agonists, 3TC, adefovir and combinations thereof.", "29.The method of claim 24, wherein the at least one additional therapeutic agent is administered simultaneous to, separate from or sequential with the compound of claim 16.30.The method of claim 16, wherein the compound is contained in a pharmaceutical composition further comprising a pharmaceutically acceptable carrier.", "31.The method of claim 16, wherein the compound is contained in a product with another HBV inhibitor, as a combined preparation for simultaneous, separate or sequential administration to the subject." ], [ "<SOH> BACKGROUND ART <EOH>The Hepatitis B virus (HBV) is an enveloped, partially double-stranded DNA (dsDNA) virus of the Hepadnavirus family (Hepadnaviridae).", "Its genome contains 4 overlapping reading frames: the precore/core gene; the polymerase gene; the L, M, and S genes, which encode for the 3 envelope proteins; and the X gene.", "Upon infection, the partially double-stranded DNA genome (the relaxed circular DNA; rcDNA) is converted to a covalently closed circular DNA (cccDNA) in the nucleus of the host cell and the viral mRNAs are transcribed.", "Once encapsidated, the pregenomic RNA (pgRNA), which also codes for core protein and Pol, serves as the template for reverse transcription, which regenerates the partially dsDNA genome (rcDNA) in the nucleocapsid.", "HBV has caused epidemics in parts of Asia and Africa, and it is endemic in China.", "HBV has infected approximately 2 billion people worldwide of which approximately 350 million people have developed chronic infections.", "The virus causes the disease hepatitis B and chronic infection is correlated with a strongly increased risk for the development cirrhosis and hepatocellular carcinoma.", "Transmission of hepatitis B virus results from exposure to infectious blood or body fluids, while viral DNA has been detected in the saliva, tears, and urine of chronic carriers with high titer DNA in serum.", "An effective and well-tolerated vaccine exists, but direct treatment options are currently limited to interferon and the following antivirals; tenofovir, lamivudine, adefovir, entecavir and telbivudine.", "In addition, heteroaryldihydropyrimidines (HAPs) were identified as a class of HBV inhibitors in tissue culture and animal models (Weber et al., Antiviral Res.", "54: 69-78).", "WO2013/006394, published on Jan. 10, 2013, relates to a subclass of Sulphamoyl-arylamides active against HBV.", "WO2013/096744, published on Jun.", "26, 2013 relates to compounds active against HBV.", "In addition, WO2014/033170 and WO2014/033176, published on Mar.", "6, 2014 relate further compounds active against HBV.", "Amongst the problems which HBV direct antivirals may encounter are toxicity, mutagenicity, lack of selectivity, poor efficacy, poor bioavailability, and difficulty of synthesis.", "There is a need for additional HBV inhibitors that may overcome at least one of these disadvantages or that have additional advantages such as increased potency or an increased safety window." ], [ "BACKGROUND ART The Hepatitis B virus (HBV) is an enveloped, partially double-stranded DNA (dsDNA) virus of the Hepadnavirus family (Hepadnaviridae).", "Its genome contains 4 overlapping reading frames: the precore/core gene; the polymerase gene; the L, M, and S genes, which encode for the 3 envelope proteins; and the X gene.", "Upon infection, the partially double-stranded DNA genome (the relaxed circular DNA; rcDNA) is converted to a covalently closed circular DNA (cccDNA) in the nucleus of the host cell and the viral mRNAs are transcribed.", "Once encapsidated, the pregenomic RNA (pgRNA), which also codes for core protein and Pol, serves as the template for reverse transcription, which regenerates the partially dsDNA genome (rcDNA) in the nucleocapsid.", "HBV has caused epidemics in parts of Asia and Africa, and it is endemic in China.", "HBV has infected approximately 2 billion people worldwide of which approximately 350 million people have developed chronic infections.", "The virus causes the disease hepatitis B and chronic infection is correlated with a strongly increased risk for the development cirrhosis and hepatocellular carcinoma.", "Transmission of hepatitis B virus results from exposure to infectious blood or body fluids, while viral DNA has been detected in the saliva, tears, and urine of chronic carriers with high titer DNA in serum.", "An effective and well-tolerated vaccine exists, but direct treatment options are currently limited to interferon and the following antivirals; tenofovir, lamivudine, adefovir, entecavir and telbivudine.", "In addition, heteroaryldihydropyrimidines (HAPs) were identified as a class of HBV inhibitors in tissue culture and animal models (Weber et al., Antiviral Res.", "54: 69-78).", "WO2013/006394, published on Jan. 10, 2013, relates to a subclass of Sulphamoyl-arylamides active against HBV.", "WO2013/096744, published on Jun.", "26, 2013 relates to compounds active against HBV.", "In addition, WO2014/033170 and WO2014/033176, published on Mar.", "6, 2014 relate further compounds active against HBV.", "Amongst the problems which HBV direct antivirals may encounter are toxicity, mutagenicity, lack of selectivity, poor efficacy, poor bioavailability, and difficulty of synthesis.", "There is a need for additional HBV inhibitors that may overcome at least one of these disadvantages or that have additional advantages such as increased potency or an increased safety window.", "DESCRIPTION OF THE INVENTION The present invention relates to a compound of Formula (ID) or a stereoisomer or tautomeric form thereof, wherein: Each X independently represents CR7; Ra, Rb and Rc are independently selected from the group consisting of Hydrogen, Fluoro, Bromo, Chloro, —CHF2, —CF2-methyl, —CH2F, —CF3, —OCF3, —CN, C1-C3alkyl and C3-C4cycloalkyl; Rd is Hydrogen or Fluoro; R4 is Hydrogen, C1-C3alkyl or C3-C4cycloalkyl; R5 is Hydrogen; R6 is selected from the group consisting of C2-C6alkyl, C1-C4alkyl-R8 optionally substituted with one or more Fluoro, C1-C4alkyl-R9 optionally substituted with one or more Fluoro, and a 3-7 membered mono or polycyclic saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or C2-C6alkyl optionally being substituted with one or more substituents each independently selected from the group consisting of Hydrogen, —OH, Fluoro, oxo, R9, R10 and C1-C4alkyl optionally substituted with R10; R7 represents hydrogen, —CN, Fluoro, Chloro, Bromo, —CHF2, —CF2-methyl, —CH2F, —CF3, C1-C3alkyl optionally substituted with methoxy, C2-C3alkenyl or C3-C4cycloalkyl; R8 represents 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring optionally being substituted with one or more C1-C4alkyl optionally substituted with R10; R9 represents, C1-C4alkyloxy, —SO2-methyl, —C(═O)—OR11 or —C(═O)—N(R11)2; R10 represents —CN, —OH, Fluoro, —CHF2, —CH2F or —CF3; R11 represents hydrogen or C1-C3alkyl; or a pharmaceutically acceptable salt or a solvate thereof wherein such compound is not The invention further relates to a pharmaceutical composition comprising a compound of Formula (ID), and a pharmaceutically acceptable carrier.", "The invention also relates to the compounds of Formula (ID) for use as a medicament, preferably for use in the prevention or treatment of an HBV infection in a mammal.", "In a further aspect, the invention relates to a combination of a compound of Formula (ID), and another HBV inhibitor.", "The pharmaceutical composition, use and combination of compounds of Formula (ID) as provided according to the present invention includes the pharmaceutical composition, use and combination of Definitions The terms “C1-xalkyl” and C1-Cxalkyl can be used interchangeably.", "The term “C1-3alkyl” as a group or part of a group refers to a hydrocarbyl radical of Formula CnH2n+1 wherein n is a number ranging from 1 to 3.In case C1-3alkyl is coupled to a further radical, it refers to a Formula CnH2n.", "C1-3alkyl groups comprise from 1 to 3 carbon atoms, more preferably 1 to 2 carbon atoms.", "C1-3alkyl includes all linear, or branched alkyl groups with between 1 and 3 carbon atoms, and thus includes such as for example methyl, ethyl, n-propyl, and i-propyl.", "C1-4alkyl as a group or part of a group defines straight or branched chain saturated hydrocarbon radicals having from 1 to 4 carbon atoms such as the group defined for C1-3alkyl and butyl and the like.", "C1-6alkyl and C2-6alkyl as a group or part of a group defines straight or branched chain saturated hydrocarbon radicals having from 1 to 6 carbon atoms, or from 2 to 6 carbon atoms such as the groups defined for C1-4alkyl and pentyl, hexyl, 2-methylbutyl and the like.", "The term “C2-3alkenyl” as a group or part of a group refers to a hydrocarbon radical comprising 2 or 3 carbon atoms having at least one double bond therein, and thus includes such as for example, ethenyl (vinyl), 1-propenyl, and 2-propenyl.", "The term “C1-3alkyloxy” as a group or part of a group refers to a radical having the Formula —ORc wherein Rc is C1-3alkyl.", "Non-limiting examples of suitable C1-3alkyloxy include methyloxy (also methoxy), ethyloxy (also ethoxy), propyloxy and isopropyloxy.", "As used herein, the term “3-7 membered mono or polycyclic saturated ring” means saturated cyclic hydrocarbon with 3, 4, 5, 6 or 7 carbon atoms and is generic to cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl (monocyclic) and fused or spiro ring systems with 2 or more saturated rings with at most 7 carbon atoms (polycyclic).", "Such saturated ring optionally contains one or more heteroatoms, such that at least one carbon atom is replaced by a heteroatom selected from N, O and S, in particular from N and O.", "Examples include oxetane, tetrahydro-2H-pyranyl, piperidinyl, tetrahydrofuranyl, morpholinyl, thiolane 1,1-dioxide and pyrrolidinyl.", "Preferred are saturated cyclic hydrocarbon with 3 or 4 carbon atoms and 1 oxygen atom.", "Examples include oxetane, and tetrahydrofuranyl.", "It should be noted that different isomers of the various heterocycles may exist within the definitions as used throughout the specification.", "For example, if not structurally specified according to the chemical name or structure, pyrrolyl may be 1H-pyrrolyl or 2H-pyrrolyl.", "The term halo and halogen are generic to Fluoro, Chloro, Bromo or Iodo.", "Preferred halogens are Bromo, Fluoro and Chloro.", "It should also be noted that the radical positions on any molecular moiety used in the definitions may be anywhere on such moiety as long as it is chemically stable.", "For instance pyridyl includes 2-pyridyl, 3-pyridyl and 4-pyridyl; pentyl includes 1-pentyl, 2-pentyl and 3-pentyl.", "Positions indicated on phenyl (e.g.", "ortho, meta and/or para) are indicated relative to the bond connecting the phenyl to the main structure.", "An example with regard to the position of para R2, location is indicated relative to the nitrogen (*) connected to the main structure: When any variable (e.g.", "halogen or C1-4alkyl) occurs more than one time in any constituent, each definition is independent.", "For therapeutic use, the salts of the compounds of Formula (ID) are those wherein the counter ion is pharmaceutically or physiologically acceptable.", "However, salts having a pharmaceutically unacceptable counter ion may also find use, for example, in the preparation or purification of a pharmaceutically acceptable compound of Formula (ID).", "All salts, whether pharmaceutically acceptable or not are included within the ambit of the present invention.", "The pharmaceutically acceptable or physiologically tolerable addition salt forms which the compounds of the present invention are able to form can conveniently be prepared using the appropriate acids, such as, for example, inorganic acids such as hydrohalic acids, e.g.", "hydrochloric or hydrobromic acid; sulfuric; hemisulphuric, nitric; phosphoric and the like acids; or organic acids such as, for example, acetic, aspartic, dodecylsulphuric, heptanoic, hexanoic, nicotinic, propanoic, hydroxyacetic, lactic, pyruvic, oxalic, malonic, succinic, maleic, fumaric, malic, tartaric, citric, methanesulfonic, ethanesulfonic, benzenesulfonic, p-toluenesulfonic, cyclamic, salicylic, p-aminosalicylic, pamoic and the like acids.", "Conversely said acid addition salt forms can be converted by treatment with an appropriate base into the free base form.", "The term “salts” also comprises the hydrates and the solvent addition forms that the compounds of the present invention are able to form.", "Examples of such forms are e.g.", "hydrates, alcoholates and the like.", "The present compounds may also exist in their tautomeric forms For example, tautomeric forms of amide (—C(═O)—NH—) groups are iminoalcohols (—C(OH)═N—).", "Tautomeric forms, although not explicitly indicated in the structural formulae represented herein, are intended to be included within the scope of the present invention.", "The term stereochemically isomeric forms of compounds of the present invention, as used hereinbefore, defines all possible compounds made up of the same atoms bonded by the same sequence of bonds but having different three-dimensional structures which are not interchangeable, which the compounds of the present invention may possess.", "Unless otherwise mentioned or indicated, the chemical designation of a compound encompasses the mixture of all possible stereochemically isomeric forms which said compound may possess.", "Said mixture may contain all diastereomers and/or enantiomers of the basic molecular structure of said compound.", "All stereochemically isomeric forms of the compounds of the present invention both in pure form or in admixture with each other are intended to be embraced within the scope of the present invention.", "Pure stereoisomeric forms of the compounds and intermediates as mentioned herein are defined as isomers substantially free of other enantiomeric or diastereomeric forms of the same basic molecular structure of said compounds or intermediates.", "In particular, the term ‘stereoisomerically pure’ concerns compounds or intermediates having a stereoisomeric excess of at least 80% (i.e.", "minimum 90% of one isomer and maximum 10% of the other possible isomers) up to a stereoisomeric excess of 100% (i.e.", "100% of one isomer and none of the other), more in particular, compounds or intermediates having a stereoisomeric excess of 90% up to 100%, even more in particular having a stereoisomeric excess of 94% up to 100% and most in particular having a stereoisomeric excess of 97% up to 100%.", "The terms ‘enantiomerically pure’ and ‘diastereomerically pure’ should be understood in a similar way, but then having regard to the enantiomeric excess, respectively the diastereomeric excess of the mixture in question.", "Pure stereoisomeric forms of the compounds and intermediates of this invention may be obtained by the application of art-known procedures.", "For instance, enantiomers may be separated from each other by the selective crystallization of their diastereomeric salts with optically active acids or bases.", "Examples thereof are tartaric acid, dibenzoyltartaric acid, ditoluoyltartaric acid and camphosulfonic acid.", "Alternatively, enantiomers may be separated by chromatographic techniques using chiral stationary phases.", "Said pure stereochemically isomeric forms may also be derived from the corresponding pure stereochemically isomeric forms of the appropriate starting materials, provided that the reaction occurs stereospecifically.", "Preferably, if a specific stereoisomer is desired, said compound will be synthesized by stereospecific methods of preparation.", "These methods will advantageously employ enantiomerically pure starting materials.", "The diastereomeric forms of Formula (ID) can be obtained separately by conventional methods.", "Appropriate physical separation methods that may advantageously be employed are, for example, selective crystallization and chromatography, e.g.", "column chromatography.", "The present invention is also intended to include all isotopes of atoms occurring on the present compounds.", "Isotopes include those atoms having the same atomic number but different mass numbers.", "By way of general example and without limitation, isotopes of Hydrogen include tritium and deuterium.", "Isotopes of carbon include C-13 and C-14.DETAILED DESCRIPTION OF THE INVENTION Whenever used hereinafter, the term “compounds of formula (ID)”, or “the present compounds” “compounds of the present invention” or similar term is meant to include the compounds of general formula (ID), (IA), (IB), (IC), (I), (Ia), (II), (III) salts, stereoisomeric forms and racemic mixtures or any subgroups thereof.", "In a first aspect, the present invention relates to a compound of Formula (ID) or a stereoisomer or tautomeric form thereof, wherein: Each X independently represents CR7; Ra, Rb and Rc are independently selected from the group consisting of Hydrogen, Fluoro, Bromo, Chloro, —CHF2, —CF2-methyl, —CH2F, —CF3, —OCF3, —CN, C1-C3alkyl and C3-C4cycloalkyl; Rd is Hydrogen or Fluoro; R4 is Hydrogen, C1-C3alkyl or C3-C4cycloalkyl; R5 is Hydrogen; R6 is selected from the group consisting of C2-C6alkyl, C1-C4alkyl-R8 optionally substituted with one or more Fluoro, C1-C4alkyl-R9 optionally substituted with one or more Fluoro, and a 3-7 membered mono or polycyclic saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or C2-C6alkyl optionally being substituted with one or more substituents each independently selected from the group consisting of Hydrogen, —OH, Fluoro, oxo, R9, R10 and C1-C4alkyl optionally substituted with RH); R7 represents hydrogen, —CN, Fluoro, Chloro, Bromo, —CHF2, —CF2-methyl, —CH2F, —CF3, C1-C3alkyl optionally substituted with methoxy, C2-C3alkenyl or C3-C4cycloalkyl; R8 represents 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring optionally being substituted with one or more C1-C4alkyl optionally substituted with R10; R9 represents, C1-C4alkyloxy, —SO2-methyl, —C(═O)—OR11 or —C(═O)—N(R11)2; R10 represents —CN, —OH, Fluoro, —CHF2, —CH2F or —CF3; R11 represents hydrogen or C1-C3alkyl; or a pharmaceutically acceptable salt or a solvate thereof wherein such compound is not In a further aspect, aspect, the present invention relates to a compound of Formula (IA) or a stereoisomer or tautomeric form thereof, wherein: Each X independently represents CR7; Ra, Rb and Rc are independently selected from the group consisting of Hydrogen, Fluoro, Bromo, Chloro, —CHF2, —CF2-methyl, —CH2F, —CF3, —OCF3, C1-C3alkyl and C3-C4cycloalkyl; R4 is Hydrogen, C1-C3alkyl or C3-C4cycloalkyl; R5 is Hydrogen; R6 is selected from the group consisting of C2-C6alkyl, C1-C4alkyl-R8 optionally substituted with one or more Fluoro, C1-C4alkyl-R9 optionally substituted with one or more Fluoro, and a 3-7 membered mono or polycyclic saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or C2-C6alkyl optionally being substituted with one or more substituents each independently selected from the group consisting of Hydrogen, —OH, Fluoro, oxo, R9, R10 and C1-C4alkyl optionally substituted with R10; R7 represents hydrogen, —CN, Fluoro, Chloro, Bromo, —CHF2, —CF2-methyl, —CH2F, —CF3, C1-C3alkyl or C3-C4cycloalkyl; R8 represents 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring optionally being substituted with one or more C1-C4alkyl optionally substituted with R10; R9 represents, C1-C4alkyloxy, —SO2-methyl, —C(═O)—OR11 or —C(═O)—N(R11)2; R10 represents —CN, —OH, Fluoro, —CHF2, —CH2F or —CF3; R11 represents hydrogen or C1-C3alkyl; or a pharmaceutically acceptable salt or a solvate thereof, wherein such compound is not In one embodiment, the present invention relates to a compound Formula (IC) or a stereoisomer or tautomeric form thereof, wherein: X represents CR7; Ra, Rb and Rc are independently selected from the group consisting of Hydrogen, Fluoro, Bromo, Chloro, —CHF2, —CF2-methyl, —CH2F, —CF3, —OCF3, C1-C3alkyl and C3-C4cycloalkyl; R4 is Hydrogen, C1-C3alkyl or C3-C4cycloalkyl; R5 is Hydrogen; R6 is selected from the group consisting of C2-C6alkyl, C1-C4alkyl-R8 optionally substituted with one or more Fluoro, C1-C4alkyl-R9 optionally substituted with one or more Fluoro, and a 3-7 membered mono or polycyclic saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or C2-C6alkyl optionally being substituted with one or more substituents each independently selected from the group consisting of Hydrogen, —OH, Fluoro, oxo, R9, R10 and C1-C4alkyl optionally substituted with R10; R7 represents hydrogen, —CN, Fluoro, Chloro, Bromo, —CHF2, —CF2-methyl, —CH2F, —CF3, C1-C3alkyl or C3-C4cycloalkyl; R8 represents 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring optionally being substituted with one or more C1-C4alkyl optionally substituted with R10; R9 represents, C1-C4alkyloxy, —SO2-methyl, —C(═O)—OR11 or —C(═O)—N(R11)2; R10 represents —CN, —OH, Fluoro, —CHF2, —CH2F or —CF3; R11 represents hydrogen or C1-C3alkyl; or a pharmaceutically acceptable salt or a solvate thereof, wherein such compound is not Of interest are compounds of the present invention wherein: Ra, Rb and Rc are independently selected from the group consisting of Hydrogen, Fluoro, Bromo, Chloro, —CHF2, —CF2-methyl, —CH2F, —CF3, —OCF3, —CN, and C1-C3alkyl; R4 is Hydrogen, or methyl; R5 is Hydrogen; R6 is selected from the group consisting of C2-C6alkyl and a 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or C2-C6alkyl optionally being substituted with one or more substituents each independently selected from the group consisting of Hydrogen, —OH, Fluoro, oxo, R9, R10 and C1-C4alkyl optionally substituted with R10; R7 represents hydrogen, —CN, Fluoro, Chloro, Bromo, —CHF2, —CF2-methyl, —CH2F, —CF3 or methyl; R9 represents, C1-C4alkyloxy, —SO2-methyl, —C(═O)—OR11 or —C(═O)—N(R11)2 R10 represents —CN, —OH, Fluoro, —CHF2, —CH2F or —CF3; R11 represents hydrogen or C1-C3alkyl.", "Another embodiment of the present invention relates to those compounds of Formula (ID), (IA) or any subgroup thereof as mentioned in any of the other embodiments wherein one or more of the following restrictions apply: (a) R4 is C1-C3alkyl, preferably methyl; R6 is selected from the group consisting of C2-C6alkyl optionally being substituted with one or more Fluoro; and R7 represents hydrogen Fluoro, Chloro or C1-C3alkyl, preferably hydrogen Fluoro, Chloro or methyl.", "(b) Rb is Hydrogen or Fluoro.", "(c) Ra and Rc are independently selected from the group consisting of Hydrogen, Fluoro, Chloro —CN and methyl.", "(d) Rb is Hydrogen or Fluoro and W and Rc are independently selected from the group consisting of Hydrogen, Fluoro, Chloro and CN.", "(e) R6 contains a 3-7 membered saturated ring optionally containing one oxygen, more specifically R6 is a 4 or 5 membered saturated ring containing one oxygen, such 4 or 5 membered saturated ring optionally substituted with C1-C4alkyl optionally substituted with R10.", "(f) R6 comprises a branched C3-C6alkyl optionally substituted with one or more Fluoro, or wherein R6 comprises a C3-C6cycloalkyl wherein such C3-C6cycloalkyl is substituted with one or more Fluoro or substituted with C1-C4alkyl substituted with one or more Fluoro, or wherein R6 comprises a C3-C6cycloalkyl optionally substituted with one or more Fluoro and/or substituted with C1-C4alkyl optionally substituted with one or more Fluoro.", "(g) R6 comprises a branched C3-C6alkyl optionally substituted with one or more Fluoro, or R6 comprises a C3-C6cycloalkyl wherein such C3-C6cycloalkyl is substituted with one or more Fluoro or substituted with C1-C4 substituted with one or more Fluoro.", "More specifically, R6 is a branched C3-C6alkyl substituted with one or more Fluoro.", "(h) R4 is C1-C3alkyl, preferably methyl; R6 is selected from the group consisting of C2-C6alkyl optionally being substituted with one or more Fluoro; and R7 represents hydrogen, Fluoro, Chloro or C1-C3alkyl, preferably hydrogen Fluoro, Chloro or methyl.", "In one aspect, the present invention relates to a compound of Formula (IA) or a stereoisomer or tautomeric form thereof, wherein: Each X independently represents CR7; Ra, Rb and Rc are independently selected from the group consisting of Hydrogen, Fluoro, Bromo, Chloro, —CHF2, —CF2-methyl, —CH2F, —CF3, —OCF3, —CN and methyl; R4 is Hydrogen or C1-C3alkyl; R5 is Hydrogen; R6 is selected from the group consisting of C2-C6alkyl, C1-C4alkyl-R8 optionally substituted with one or more Fluoro, C1-C4alkyl-R9 optionally substituted with one or more Fluoro, and a 3-7 membered mono or polycyclic saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or C2-C6alkyl optionally being substituted with one or more substituents each independently selected from the group consisting of Hydrogen, —OH, Fluoro, oxo, R9, R10 and C1-C4alkyl optionally substituted with RH); R7 represents hydrogen, methyl, CN, Fluoro or Chloro; R8 represents 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring optionally being substituted with one or more C1-C4alkyl optionally substituted with R10; R9 represents, C1-C4alkyloxy, —SO2-methyl, —C(═O)—OR11 or —C(═O)—N(R11)2; R10 represents —CN, —OH, Fluoro, —CHF2, —CH2F or —CF3; R11 represents hydrogen or C1-C3alkyl; or a pharmaceutically acceptable salt or a solvate thereof, wherein such compound is not In a further aspect, the present invention relates to a compound of Formula (IA) or a stereoisomer or tautomeric form thereof, wherein: Each X independently represents CR7; Ra, Rb and Rc are independently selected from the group consisting of Hydrogen, Fluoro, Bromo, Chloro, —CHF2, —CF2-methyl, —CH2F, —CF3, —OCF3, —CN and methyl; R4 is Hydrogen or C1-C3alkyl; R5 is Hydrogen; R6 is selected from the group consisting of C2-C6alkyl, C1-C4alkyl-R8 optionally substituted with one or more Fluoro, C1-C4alkyl-R9 optionally substituted with one or more Fluoro, and a 3-7 membered mono or polycyclic saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or C2-C6alkyl optionally being substituted with one or more substituents each independently selected from the group consisting of Hydrogen, —OH, Fluoro, oxo, R9, R10 and C1-C4alkyl optionally substituted with R10); R7 represents hydrogen, methyl, Fluoro or Chloro; R8 represents 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring optionally being substituted with one or more C1-C4alkyl optionally substituted with R10; R9 represents, C1-C4alkyloxy, —SO2-methyl, —C(═O)—OR11 or —C(═O)—N(R11)2; R10 represents —CN, —OH, Fluoro, —CHF2, —CH2F or —CF3; R11 represents hydrogen or C1-C3alkyl; or a pharmaceutically acceptable salt or a solvate thereof, wherein such compound is not In a further aspect, the invention relates to compound of Formula or a stereoisomer or tautomeric form thereof, wherein: Each X independently represents CR7; Ra, Rb and Rc are independently selected from the group consisting of Hydrogen, Fluoro, Bromo, Chloro, —CHF2, —CF2-methyl, —CH2F, —CF3, —OCF3, —CN and methyl; R4 is Hydrogen or C1-C3alkyl; R5 is Hydrogen; R6 is selected from the group consisting of C2-C6alkyl, C1-C4alkyl-R8 optionally substituted with one or more Fluoro, C1-C4alkyl-R9 optionally substituted with one or more Fluoro, and a 3-7 membered mono or polycyclic saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or C2-C6alkyl optionally being substituted with one or more substituents each independently selected from the group consisting of Hydrogen, —OH, Fluoro, oxo, R9, R10 and C1-C4alkyl optionally substituted with R10; R7 represents hydrogen, methyl, Fluoro or Chloro; R8 represents 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring optionally being substituted with one or more C1-C4alkyl optionally substituted with R10; R9 represents, C1-C4alkyloxy, —SO2-methyl, —C(═O)—OR11 or —C(═O)—N(R11)2 R10 represents —CN, —OH, Fluoro, —CHF2, —CH2F or —CF3; R11 represents hydrogen or C1-C3alkyl; or a pharmaceutically acceptable salt or a solvate thereof, wherein such compound is not In one embodiment of compounds of the present invention, R4 is methyl.", "In a further embodiment of compounds of the present invention, Rb is Hydrogen or Fluoro.", "Furthermore, compounds according to the invention are described wherein Ra and Rc are independently selected from the group consisting of Hydrogen, Fluoro, Chloro —CN and methyl.", "Preferably, Rb is Hydrogen or Fluoro and Ra and Rc are independently selected from the group consisting of Hydrogen, Fluoro, Chloro and —CN.", "In one embodiment of compounds of the present invention, R6 is selected from the group consisting of C2-C6alkyl, C1-C4alkyl-R8 optionally substituted with one or more Fluoro, C1-C4alkyl-R9 optionally substituted with one or more Fluoro, and a 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or C2-C6alkyl optionally being substituted with one or more substituents each independently selected from the group consisting of Hydrogen, —OH, Fluoro, oxo, R9, W° and C1-C4alkyl optionally substituted with R10.In a further embodiment, R6 contains a 3-7 membered saturated ring optionally containing one oxygen, more specifically R6 is a 5 membered saturated ring containing one oxygen, such 5 membered saturated ring optionally substituted with C1-C4alkyl optionally substituted with R10.In one embodiment of compounds of the present invention, R6 comprises a branched C3-C6alkyl optionally substituted with one or more Fluoro, or R6 comprises a C3-C6cycloalkyl wherein such C3-C6cycloalkyl is substituted with one or more Fluoro or substituted with C1-C4 substituted with one or more Fluoro.", "More specifically, R6 is a branched C3-C6alkyl substituted with one or more Fluoro.", "In a further aspect, the invention provides compound of Formula (I) or a stereoisomer or tautomeric form thereof, wherein: Each X independently represents CR7; R2 is Hydrogen, CN, Chloro or Fluoro; R1 and R3 are independently selected from the group consisting of Hydrogen, Fluoro, Bromo, Chloro, —CHF2, —CH2F, —CF3, —OCF3, —CN and methyl, wherein at maximum one of R1 R2 and R3 is Hydrogen if one of R1 and R3 is Chloro or —OCF3; R4 is Hydrogen or C1-C3alkyl; R5 is Hydrogen; R6 is selected from the group consisting of C2-C6alkyl, C1-C4alkyl-R8 optionally substituted with one or more Fluoro, C1-C4alkyl-R9 optionally substituted with one or more Fluoro, and a 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or —C2-C6alkyl optionally being substituted with one or more substituents each independently selected from the group consisting of Hydrogen, —OH, Fluoro, oxo and C1-C4alkyl optionally substituted with R10; R7 represents hydrogen, methyl, Fluoro or Chloro; R8 represents 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring optionally being substituted with one or more C1-C4alkyl optionally substituted with R10; R9 represents, C1-C4alkyloxy, —SO2-methyl, —C(═O)—OR11 or —C(═O)—N(R11)2 R10 represents —CN, —OH, Fluoro, —CHF2, —CH2F or —CF3; R11 represents hydrogen or C1-C3alkyl; or a pharmaceutically acceptable salt or a solvate thereof.", "In one embodiment, compounds of Formula (I) are disclosed wherein: Each X independently represents CR7; R2 is Hydrogen, CN, or Fluoro; R1 and R3 are independently selected from the group consisting of Hydrogen, Fluoro, Bromo, Chloro, —CHF2, —CH2F, —CF3, —CN and methyl, wherein at maximum one of R1 R2 and R3 is Hydrogen if one of R1 and R3 is Chloro; R4 is Hydrogen or C1-C3alkyl; R5 is Hydrogen; R6 is selected from the group consisting of C2-C6alkyl, C1-C4alkyl-R8, C1-C4alkyl-R9 and a 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or —C2-C6alkyl optionally being substituted with one or more substituents each independently selected from the group consisting of Hydrogen, —OH, Fluoro, oxo and C1-C4alkyl optionally substituted with R10; R7 represents hydrogen, methyl, Fluoro or Chloro; R8 represents 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring optionally being substituted with one or more C1-C4alkyl optionally substituted with RE); R9 represents —C(═O)—OR11 or —C(═O)—N(R11)2; R10 represents —CN, —OH, Fluoro, —CHF2, —CH2F or —CF3; and R11 represents hydrogen or C1-C3alkyl.", "In one further embodiment, compounds of Formula (I) are disclosed wherein: Each X independently represents CR7; R2 is Hydrogen or Fluoro; R1 and R3 are independently selected from the group consisting of Hydrogen, Fluoro, Bromo, Chloro, CHF2, CH2F, CF3 and methyl, wherein at maximum one of R1, R2 and R3 is Hydrogen; R4 is Hydrogen or methyl; R5 is Hydrogen; R6 is selected from the group consisting of C2-C6alkyl, C1-C3alkyl-R8 and a 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or C2-C6alkyl optionally being substituted with one or more substituents each independently selected from the group consisting of Hydrogen, OH, Fluoro, and C1-C4alkyl; R7 represents Hydrogen, methyl, Fluoro or Chloro; R8 represents 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N. In one embodiment, for compounds according to Formula (I), at least one X represents CH.", "In a further aspect, the invention provides compounds of Formula (Ia) or a stereoisomer or tautomeric form thereof, wherein: R2 is Hydrogen, CN or Fluoro; R1 and R3 are independently selected from the group consisting of Hydrogen, Fluoro, Bromo, Chloro, —CHF2, —CH2F, —CF3, —CN and methyl, wherein at maximum one of R1, R2 and R3 is Hydrogen if one of R1 and R3 is Chloro; R4 is Hydrogen or C1-C3alkyl; R5 is Hydrogen; R6 is selected from the group consisting of C2-C6alkyl, C1-C4alkyl-R8, C1-C4alkyl-R9 and a 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or —C2-C6alkyl optionally being substituted with one or more substituents each independently selected from the group consisting of Hydrogen, —OH, Fluoro, oxo and C1-C4alkyl optionally substituted with R10; R7 represents hydrogen, methyl, Fluoro or Chloro; R8 represents 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring optionally being substituted with one or more C1-C4alkyl optionally substituted with R10; R9 represents —C(═O)—OR11 or —C(═O)—N(R11)2 R10 represents —CN, —OH, Fluoro, —CHF2, —CH2F or —CF3, R11 represents hydrogen or C1-C3alkyl; or a pharmaceutically acceptable salts or a solvate thereof.", "In a sub-embodiment, compounds of Formula (I) are disclosed wherein: R2 is Hydrogen or Fluoro; R1 and R3 are independently selected from the group consisting of Hydrogen, Fluoro, CHF2, CH2F, CF3 and methyl, wherein at maximum one of R1, R2 and R3 is Hydrogen; R4 is Hydrogen or methyl; R5 is Hydrogen; R6 is selected from the group consisting of C2-C6alkyl and a 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or C1-C6alkyl optionally being substituted with one or more substituents each independently selected from the group consisting of Hydrogen, OH and C1-C4alkyl.", "In another embodiment, compounds of the invention are represented by Formula (II) In yet another embodiment, compounds of the invention are represented by Formula (III) For both compounds of Formula (II) and (III): R2 is Hydrogen, CN or Fluoro; R1 is independently selected from the group consisting of Fluoro, Bromo, Chloro, —CHF2, —CH2F, —CF3, —CN and methyl, wherein if R1 is Chloro, R2 is not Hydrogen; R4 is Hydrogen or C1-C3alkyl; R5 is Hydrogen; R6 is selected from the group consisting of C2-C6alkyl, C1-C4alkyl-R8, C1-C4alkyl-R9 and a 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or —C2-C6alkyl optionally being substituted with one or more substituents each independently selected from the group consisting of Hydrogen, —OH, Fluoro, oxo and C1-C4alkyl optionally substituted with R10; R7 represents hydrogen, methyl, Fluoro or Chloro; R8 represents 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring optionally being substituted with one or more C1-C4alkyl optionally substituted with R10; R9 represents —C(═O)—OR11 or —C(═O)—N(R11)2 R10 represents —CN, —OH, Fluoro, —CHF2, —CH2F or —CF3; R11 represents hydrogen or C1-C3alkyl.", "In one embodiment, compounds of the present invention are disclosed wherein R1 is selected from either Bromo, Chloro, Fluoro or methyl, or Fluoro or methyl.", "In another embodiment, R1 is selected from either Fluoro or methyl and at least one of R1 and R3 is Fluoro.", "In yet a further embodiment, R1 is selected from either Fluoro or methyl and at least one of R1 and R3 is Fluoro, and the other R1 or R3 is selected from methyl, Fluoro, CHF2, CH2F, CF3 and methyl.", "In another embodiment, at least two of R1, R2 and R3 are halogens, preferably Bromo, Fluoro or Chloro, even more preferably Fluoro or Chloro.", "In a further embodiment, each of R1, R2 and R3 are halogen, preferably Bromo, Fluoro or Chloro, even more preferably Fluoro or Chloro.", "In yet another embodiment, compounds of the present invention are disclosed wherein R4 is methyl or ethyl, preferably methyl.", "In a further embodiment, compounds of the present invention are disclosed wherein R6 contains a 3-7 membered saturated ring optionally containing one oxygen, preferably R6 is a 5 membered saturated ring containing one oxygen.", "In another embodiment, compounds of the present invention are disclosed wherein R6 comprises a C1-C4alkyl substituted with one or more Fluoro.", "In addition, compounds of the present invention are disclosed wherein R6 comprises a branched C3-C6alkyl substituted with one or more Fluoro, or wherein R6 comprises a C3-C6cycloalkyl wherein such C3-C6cycloalkyl is substituted with one or more Fluoro or substituted with C1-C4 substituted with one or more Fluoro.", "In yet another embodiment, compounds of the invention are disclosed wherein R6 comprises a carbon atom without hydrogen substituent.", "Preferably, carbon without hydrogen substituent is directly attached to the Nitrogen of the —N—SO1˜ moiety.", "Further combinations of any of the embodiments are also envisioned to be in the scope of the present invention.", "Preferred compounds according to the invention are compound or a stereoisomer or tautomeric form thereof with a formula as represented in the synthesis of compounds section and of which the activity is displayed in Table 1.In a further aspect, the present invention concerns a pharmaceutical composition comprising a therapeutically or prophylactically effective amount of a compound of Formula (ID) as specified herein, and a pharmaceutically acceptable carrier.", "A prophylactically effective amount in this context is an amount sufficient to prevent HBV infection in subjects being at risk of being infected.", "A therapeutically effective amount in this context is an amount sufficient to stabilize HBV infection, to reduce HBV infection, or to eradicate HBV infection, in infected subjects.", "In still a further aspect, this invention relates to a process of preparing a pharmaceutical composition as specified herein, which comprises intimately mixing a pharmaceutically acceptable carrier with a therapeutically or prophylactically effective amount of a compound of Formula (ID), as specified herein.", "Therefore, the compounds of the present invention or any subgroup thereof may be formulated into various pharmaceutical forms for administration purposes.", "As appropriate compositions there may be cited all compositions usually employed for systemically administering drugs.", "To prepare the pharmaceutical compositions of this invention, an effective amount of the particular compound, optionally in addition salt form, as the active ingredient is combined in intimate admixture with a pharmaceutically acceptable carrier, which carrier may take a wide variety of forms depending on the form of preparation desired for administration.", "These pharmaceutical compositions are desirable in unitary dosage form suitable, particularly, for administration orally, rectally, percutaneously, or by parenteral injection.", "For example, in preparing the compositions in oral dosage form, any of the usual pharmaceutical media may be employed such as, for example, water, glycols, oils, alcohols and the like in the case of oral liquid preparations such as suspensions, syrups, elixirs, emulsions and solutions; or solid carriers such as starches, sugars, kaolin, lubricants, binders, disintegrating agents and the like in the case of powders, pills, capsules, and tablets.", "Because of their ease in administration, tablets and capsules represent the most advantageous oral dosage unit forms, in which case solid pharmaceutical carriers are employed.", "For parenteral compositions, the carrier will usually comprise sterile water, at least in large part, though other ingredients, for example, to aid solubility, may be included.", "Injectable solutions, for example, may be prepared in which the carrier comprises saline solution, glucose solution or a mixture of saline and glucose solution.", "Injectable suspensions may also be prepared in which case appropriate liquid carriers, suspending agents and the like may be employed.", "Also included are solid form preparations intended to be converted, shortly before use, to liquid form preparations.", "In the compositions suitable for percutaneous administration, the carrier optionally comprises a penetration enhancing agent and/or a suitable wetting agent, optionally combined with suitable additives of any nature in minor proportions, which additives do not introduce a significant deleterious effect on the skin.", "The compounds of the present invention may also be administered via oral inhalation or insufflation in the form of a solution, a suspension or a dry powder using any art-known delivery system.", "It is especially advantageous to formulate the aforementioned pharmaceutical compositions in unit dosage form for ease of administration and uniformity of dosage.", "Unit dosage form as used herein refers to physically discrete units suitable as unitary dosages, each unit containing a predetermined quantity of active ingredient calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier.", "Examples of such unit dosage forms are tablets (including scored or coated tablets), capsules, pills, suppositories, powder packets, wafers, injectable solutions or suspensions and the like, and segregated multiples thereof.", "The compounds of Formula (ID) are active as inhibitors of the HBV replication cycle and can be used in the treatment and prophylaxis of HBV infection or diseases associated with HBV.", "The latter include progressive liver fibrosis, inflammation and necrosis leading to cirrhosis, end-stage liver disease, and hepatocellular carcinoma.", "Due to their antiviral properties, particularly their anti-HBV properties, the compounds of Formula (ID) or any subgroup thereof, are useful in the inhibition of the HBV replication cycle, in particular in the treatment of warm-blooded animals, in particular humans, infected with HBV, and for the prophylaxis of HBV infections.", "The present invention furthermore relates to a method of treating a warm-blooded animal, in particular human, infected by HBV, or being at risk of infection by HBV, said method comprising the administration of a therapeutically effective amount of a compound of Formula (ID).", "The compounds of Formula (ID), as specified herein, may therefore be used as a medicine, in particular as medicine to treat or prevent HBV infection.", "Said use as a medicine or method of treatment comprises the systemic administration to HBV infected subjects or to subjects susceptible to HBV infection of an amount effective to combat the conditions associated with HBV infection or an amount effective to prevent HBV infection.", "The present invention also relates to the use of the present compounds in the manufacture of a medicament for the treatment or the prevention of HBV infection.", "In general it is contemplated that an antiviral effective daily amount would be from about 0.01 to about 50 mg/kg, or about 0.01 to about 30 mg/kg body weight.", "It may be appropriate to administer the required dose as two, three, four or more sub-doses at appropriate intervals throughout the day.", "Said sub-doses may be formulated as unit dosage forms, for example, containing about 1 to about 500 mg, or about 1 to about 300 mg, or about 1 to about 100 mg, or about 2 to about 50 mg of active ingredient per unit dosage form.", "The present invention also concerns combinations of a compound of Formula (ID) or any subgroup thereof, as specified herein with other anti-HBV agents.", "The term “combination” may relate to a product or kit containing (a) a compound of Formula (ID), as specified above, and (b) at least one other compound capable of treating HBV infection (herein designated as anti-HBV agent), as a combined preparation for simultaneous, separate or sequential use in treatment of HBV infections.", "In an embodiment, the invention concerns combination of a compound of Formula (ID) or any subgroup thereof with at least one anti-HBV agent.", "In a particular embodiment, the invention concerns combination of a compound of Formula (ID) or any subgroup thereof with at least two anti-HBV agents.", "In a particular embodiment, the invention concerns combination of a compound of Formula (ID) or any subgroup thereof with at least three anti-HBV agents.", "In a particular embodiment, the invention concerns combination of a compound of Formula (ID) or any subgroup thereof with at least four anti-HBV agents.", "The term anti-HBV agent also includes compounds capable of treating HBV infection via immunomodulation.", "Examples of immunomodulators are interferon-α (IFN-α), pegylated interferon-α or stimulants of the innate immune system such as Toll-like receptor 7 and/or 8 agonists.", "One embodiment of the present invention relates to combinations of a compound of Formula (ID) or any subgroup thereof, as specified herein with an immunomodulating compound, more specifically a Toll-like receptor 7 and/or 8 agonist.", "The combination of previously known anti-HBV agents, such as interferon-α (IFN-α), pegylated interferon-α, 3TC, adefovir or a combination thereof, and, a compound of Formula (ID) or any subgroup thereof can be used as a medicine in a combination therapy.", "Generic Synthesis: The substituents represented in this general synthesis section are meant to include any substituent or reactive species that is suitable for transformation into any substituent according to the present invention without undue burden for the person skilled in the art.", "A possible synthesis of compound of general formula (I) is described in schemes 1 and 2.Similarly, the synthesis of compounds of general formula (IA) are described in schemes 1a, 2a.", "Also similarly, the synthesis of compounds of general formula ID is described in scheme 1b and scheme 2b.", "A carboxylic acid chloride of general formula (IV) (for example prepared according to the synthesis described for compound 2) can be selectively reacted with an aniline of general formula (V), for example by slow addition of aniline (V) to a refluxing solution of compound (IV) in toluene, resulting in compound (VI).", "The remaining sulfonic acid chloride functionality in compound (VI) is further reacted with an amine of general formula (VII), resulting in a compound of general formula (I), for example in a solvent like acetonitrile in the presence of an inorganic base like sodium bicarbonate or as further exemplified in the experimental synthetic description of compounds.", "Alternatively a compound of general formula (I) might be obtained as described in scheme 2.This time the sulfonic acid chloride (VIII) (for example prepared according to the synthesis described for compound 2) is reacted with an amine of general formula (VII), for example in an organic solvent like CH2Cl2 in the presence of an organic base like triethylamine or DIPEA.", "The formed compound (IX) is coupled with aniline of general formula (V) in the presence of an activating reagent like for example HATU and an organic base like triethylamine or DIPEA.", "An alternative method for the synthesis of compounds of general formula IX, is via ester X as described in scheme 3.Reaction of X with amine VII, for example in an organic solvent like acetonitrile in the presence of an organic base like for example triethylamine or DIPEA, or an inorganic base like for example sodium bicarbonate, resulting in a compound of general formula XI, followed by hydrolysis of the ester, for example with LiOH in THF/H2O, followed by acidification, results in a compound of general formula IX.", "A compound of general formula VIII can be converted to a compound of general formula IV, for example by treatment with oxalyl chloride in CH2Cl2.Possible synthetic routes, for compounds of general formula X and VIII are described in scheme 4, and further exemplified in the experimental section.", "Chlorosulfonation of carboxylic ester XII or carboxylic acid XIII, can results in compounds of general formula X or VIII respectively, for example by treatment with chlorosulfonic acid at for example 0° C., if necessary, followed by quenching with water.", "Alternatively, compound XII can be treated with chlorosulfonic acid, resulting in a sulfonic acid derivative, for example by treatment of compound XII with 1-1.2 equiv chlorosulfonic acid in CH2Cl2, the resulting sulfonic acid derivative can be converted the sulfonyl chloride compound X, for example by treatment with SOCl2 at 80° C. Alternatively a compound of general formula (IA) might be obtained as described in scheme 5.A compound of general formula XI can be coupled with a compound of general formula Va in the presence of a base like for example lithium bis(trimethylsilyl)amide, in a solvent like for example THF, resulting in the formation of a compound of general formula (IA).", "Similarly, a compound of general formula ID can be prepared as described in scheme 5a.", "General Procedure LCMS Methods The High Performance Liquid Chromatography (HPLC) measurement was performed using a LC pump, a diode-array (DAD) or a UV detector and a column as specified in the respective methods.", "If necessary, additional detectors were included (see table of methods below).", "Flow from the column was brought to the Mass Spectrometer (MS) which was configured with an atmospheric pressure ion source.", "It is within the knowledge of the skilled person to set the tune parameters (e.g.", "scanning range, dwell time .", ".", ". )", "in order to obtain ions allowing the identification of the compound's nominal monoisotopic molecular weight (MW).", "Data acquisition was performed with appropriate software.", "Compounds are described by their experimental retention times (Rt) and ions.", "If not specified differently in the table of data, the reported molecular ion corresponds to the [M+H]+(protonated molecule) and/or [M−H]− (deprotonated molecule).", "In case the compound was not directly ionizable the type of adduct is specified (i.e.", "[M+NH4]+, [M+HCOO]−, etc.).", "All results were obtained with experimental uncertainties that are commonly associated with the method used.", "Hereinafter, “SQD” means Single Quadrupole Detector, “MSD” Mass Selective Detector, “RT” room temperature, “BEH” bridged ethylsiloxane/silica hybrid, “DAD” Diode Array Detector, “HSS” High Strength silica, “Q-Tof” Quadrupole Time-of-flight mass spectrometers, “CLND”, ChemiLuminescent Nitrogen Detector, “ELSD” Evaporative Light Scanning Detector, LCMS Methods (Flow expressed in mL/min; column temperature (T) in ° C.; Run time in minutes).", "Method Flow Run code Instrument Column Mobile phase Gradient Col T time A Waters: Waters: A: 10 mM From 100% A 0.8 3.5 Acquity ® HSS CH3COONH4 to 5% A in 55 UPLC ® - T3 in 95% H2O + 2.10 min, to 0% DAD and (1.8 μm, 5% CH3CN A in 0.90 min, SQD 2.1 * 100 mm) B: CH3CN to 5% A in 0.5 min B Waters: Waters: A: 10 mM From 95% A 0.8 2 Acquity ® BEH CH3COONH4 to 5% A in 1.3 min, 55 UPLC ® - C18 in 95% H2O + held for DAD and (1.7 μm, 5% CH3CN 0.7 min.", "SQD 2.1 * 50 mm) B: CH3CN C Waters: Waters: A: 10 mM From 95% A 0.8 3 Acquity ® HSS CH3COONH4 to 0% A in 55 UPLC ® - T3 in 95% H2O + 2.5 min, to 5% DAD and (1.8 μm, 5% CH3CN A in 0.5 min SQD 2.1 * 100 mm) B: CH3CN D Waters: Waters: A: 10 mM From 100% A 0.7 3.5 Acquity ® HSS CH3COONH4 to 5% A in 55 UPLC ® - T3 in 95% H2O + 2.10 min, to 0% DAD and (1.8 μm, 5% CH3CN A in 0.90 min, SQD 2.1 * 100 mm) B: CH3CN to 5% A in 0.5 min Synthesis of Compounds Compound 1: N-(4-fluoro-3-methyl-phenyl)-4-(isopropylsulfamoyl)-1H-pyrrole-2-carboxamide 4-(isopropylsulfamoyl)-1H-Pyrrole-2-carboxylic acid (857 mg, 3.69 mmol), 4-Fluoro-3-Methylaniline (461.8 mg, 369 mmol), COMU ((1-Cyano-2-ethoxy-2-oxoethyliden-aminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate; CAS Number 1075198-30-9; 1738 mg, 4.06 mmol) and triethylamine (2.0 mL, 4.06 mmol) in dichloromethane (43 mL) was stirred for 3 hours.", "The reaction mixture was treated with 1M HCl (50 mL).", "The precipitate was filtered off and was recrystallized from hot acetonitrile (50 mL).", "The solid was filtered and dried overnight in vacuo yielding a beige powder (58 mg).", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.00 (d, J=6.4 Hz, 6H), 2.23 (d, J=1.5 Hz, 3H), 3.20-3.31 (m, 1H), 7.05-7.20 (m, 2H), 7.31-7.34 (m, 1H), 7.34-7.38 (m, 1H), 7.54-7.60 (m, 1H), 7.62 (dd, J=7.2, 2.3 Hz, 1H), 10.01 (s, 1H), 12.33 (br.", "s., 1H).", "Method A; Rt: 1.51 min.", "m/z: 338.0 (M−H)− Exact mass: 339.1.Compound 2: N-(4-fluoro-3-methyl-phenyl)-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide A mixture of 4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxylic acid (Commercial from enamine, EN300-30498, 954 mg, 3.87 mmol) 4-Fluoro-3-Methylaniline (485 mg, 3.87 mmol), COMU (1825 mg, 4.261 mmol) and triethylamine (2.15 mL, 4.26 mmol) in dichloromethane (50 mL) was stirred for 3 hours.", "The reaction mixture was washed with 1M HCl (50 mL), water and NaHCO3 solution, dried over sodium sulphate, filtered and concentrated.", "The obtained residue was purified by Preparative HPLC (Stationary phase: RP Vydac Denali C18—10 μm, 200 g, 5 cm), Mobile phase: 0.25% NH4HCO3 solution in water, CH3CN).", "The product fractions were concentrated yielding a white powder which was dried overnight in vacuo at 50° C. (30 mg).", "Method A; Rt: 1.73 min.", "m/z: 354.0 (M+H)+ Exact mass: 353.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.02 (d, J=6.6 Hz, 6H), 2.23 (d, J=1.8 Hz, 3H), 3.21-3.30 (m, 1H), 3.91 (s, 3H), 7.09 (t, J=9.2 Hz, 1H), 7.17 (d, J=6.8 Hz, 1H), 7.30 (d, J=2.0 Hz, 1H), 7.45-7.57 (m, 2H), 7.64 (dd, J=7.0, 2.4 Hz, 1H), 10.01 (s, 1H).", "Synthesis of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride and 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride 1-Methyl-1H-pyrrole-2-carboxylic acid (5520 mg, 44.1 mmol) was dissolved portion wise in chlorosulfonic acid (25 mL) in an ice bath.", "The mixture was stirred for 70 minutes.", "The mixture was added drop wise to ice/water (200 mL) and stirred for 5 minutes.", "The precipitate was filtered, rinsed with water and dried overnight in vacuo at 50° C. resulting in 4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylic acid as a powder (5632 mg).", "Oxalyl chloride (22.4 g, 176.8 mmol) was added portion wise to 4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylic acid (obtained as described above, 7.9 g, 35.37 mmol) and DMF (0.14 mL) in CH2Cl2 (200 mL) and the mixture was stirred over weekend at room temperature.", "The reaction mixture was concentrated yielding 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride as a brown solid (8.6 g) which was used as such.", "4-fluoro-3-methyl-aniline (2049 mg, 16.37 mmol) was dissolved in toluene (20 mL) and added drop wise to a solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride (3963 mg, 16.37 mmol) in toluene (200 mL) at reflux.", "The reaction mixture was refluxed 1 hour and allowed to cool to room temperature overnight.", "The formed precipitate was filtered and dried in vacuo at 50° C. resulting in 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (3.14 g) as a powder.", "Method A; Rt: 1.96 min.", "m/z: 328.9 (M−H)− Exact mass: 330.0.1H NMR (400 MHz, CHLOROFORM-d) δ ppm 2.29 (d, J=1.8 Hz, 3H), 4.05 (s, 3H), 7.00 (t, J=9.0 Hz, 1H), 7.15 (d, J=1.8 Hz, 1H), 7.27-7.32 (m, 1H), 7.42 (dd, J=6.6, 2.6 Hz, 1H), 7.50 (d, J=1.8 Hz, 1H), 7.63 (br.", "s., 1H).", "Compound 3: N-(4-fluoro-3-methyl-phenyl)-4-[[(1R)-2-hydroxy-1-methyl-ethyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide A mixture of D-alaninol (696 mg, 9.08 mmol) and DIPEA (1.3 mL, 7.57 mmol) dissolved in dichloromethane (25 mL) was added to a solution of 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (2250 mg).", "The reaction mixture was stirred 15 minutes.", "More D-alaninol (1.5 eq) and DIPEA (2 eq) were added and the reaction mixture was stirred 15 minutes more.", "The reaction mixture was washed with 1M HCl (3×), water and NaHCO3 solution.", "The organic layer was dried over MgSO4, filtered and concentrated.", "The obtained residue was purified by column chromatography on silica using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated and the obtained residue was crystallized from warm EtOAc (50 mL) by slowly adding heptane.", "Compound 3 was filtered off as white crystals and dried in vacuo at 50° C. (342 mg).", "Method A; Rt: 1.47 min.", "m/z: 370.2 (M+H)+ Exact mass: 369.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.98 (d, J=6.2 Hz, 3H), 2.23 (d, J=1.5 Hz, 3H), 3.07-3.18 (m, 2H), 3.32-3.39 (m, 1H), 3.91 (s, 3H), 4.65 (t, J=5.5 Hz, 1H), 7.03-7.15 (m, 2H), 7.30 (d, J=1.8 Hz, 1H), 7.47-7.57 (m, 2H), 7.64 (dd, J=7.0, 2.4 Hz, 1H), 10.02 (s, 1H).", "Compound 4: N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(3S)-tetrahydrofuran-3-yl]-sulfamoyl]pyrrole-2-carboxamide A mixture of (S)-Tetrahydro-3-furylamine p-toluenesulfonate salt (822 mg, 3.17 mmol) and DIPEA (1.09 mL, 6.34 mmol) in dichloromethane (25 mL), was added to a solution of 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (785 mg) in dichloromethane (50 mL) and stirred overnight.", "The reaction mixture was washed with 1M HCl (3×), water and NaHCO3 solution.", "The organic layer was dried over MgSO4, filtered and concentrated.", "The residue was purified by column chromatography on silica using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated yielding compound 4 as a beige solid which was dried overnight in vacuo at 50° C. (696 mg).", "Method A; Rt: 1.57 min.", "m/z: 382.0 (M+H)+ Exact mass: 381.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.66-1.77 (m, 1H), 1.91-2.04 (m, 1H), 2.23 (d, J=1.5 Hz, 3H), 3.39-3.47 (m, 1H), 3.61 (td, J=8.0, 5.9 Hz, 1H), 3.66-3.76 (m, 3H), 3.92 (s, 3H), 7.09 (t, J=9.1 Hz, 1H), 7.31 (d, J=2.0 Hz, 1H), 7.47-7.59 (m, 3H), 7.64 (dd, J=7.2, 2.3 Hz, 1H), 10.03 (s, 1H).", "Compound 5: N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)-sulfamoyl]pyrrole-2-carboxamide A mixture of 3-methyl-3-oxetanamine hydrochloride (1:1) (391.5 mg, 3.17 mmol) and DIPEA (1.09 mL, 6.34 mmol) in dichloromethane (25 mL) was added to a solution of 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (785 mg) in dichloromethane (50 mL) and stirred overnight.", "The reaction mixture was washed with 1M HCl (3×), water and NaHCO3 solution.", "The organic layer was dried over MgSO4, filtered and concentrated.", "The obtained residue was purified by silica gel column chromatography using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated yielding compound 5 as a beige solid which was dried overnight in vacuo at 50° C. (584 mg).", "Method A; Rt: 1.57 min.", "m/z: 399.2 (M+NH4)+ Exact mass: 381.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.55 (s, 3H), 2.23 (d, J=1.5 Hz, 3H), 3.91 (s, 3H), 4.13 (d, J=6.0 Hz, 2H), 4.60 (d, J=6.0 Hz, 2H), 7.09 (t, J=9.1 Hz, 1H), 7.32 (d, J=2.0 Hz, 1H), 7.48-7.54 (m, 1H), 7.56 (d, J=1.8 Hz, 1H), 7.63 (dd, J=7.0, 2.4 Hz, 1H), 7.94 (s, 1H), 10.02 (s, 1H).", "Compound 6: N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(1R)-1-methylpropyl]-sulfamoyl]pyrrole-2-carboxamide A mixture of (R)-(−)-2-aminobutane (231.7 mg, 3.17 mmol) and DIPEA (1.09 mL, 6.34 mmol) in dichloromethane (25 mL) was added to a solution of 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (785 mg) in dichloromethane (50 mL) and stirred overnight.", "The reaction mixture was washed with 1M HCl (3×), water and NaHCO3 solution.", "The organic layer was dried over MgSO4, filtered and concentrated.", "The obtained residue was purified by column chromatography on silica using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated yielding compound 6 as a beige solid which was dried overnight in vacuo at 50° C. (540 mg).", "Method A; Rt: 1.78 min.", "m/z: 368.1 (M+H)+ Exact mass: 367.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.77 (t, J=7.4 Hz, 3H), 0.96 (d, J=6.4 Hz, 3H), 1.29-1.41 (m, 2H), 2.23 (d, J=1.5 Hz, 3H), 3.01-3.12 (m, 1H), 3.91 (s, 3H), 7.04-7.16 (m, 2H), 7.30 (d, J=2.0 Hz, 1H), 7.46-7.57 (m, 2H), 7.64 (dd, J=7.0, 2.4 Hz, 1H), 10.00 (s, 1H).", "Alternative Synthesis of Compound 2: A solution of isopropylamine (499 mg, 8.45 mmol) in dichloromethane (25 mL) was added to a solution of 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (785 mg).", "The reaction mixture was stirred overnight.", "The reaction mixture was washed with 1M HCl (3×), water and NaHCO3 solution.", "The organic layer was dried over MgSO4, filtered and concentrated.", "The obtained residue was recrystallized by slowly adding heptanes to warm EtOAc (50 mL) solution of compound 2.Compound 2 was filtered off as white solid and dried in vacuo at 50° C. (357 mg).", "Compound 7: N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)methyl-sulfamoyl]pyrrole-2-carboxamide A solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride (5.05 g, 0.021 mol) in toluene (225 mL) was stirred at reflux under N2-flow.", "A solution of 4-fluoro-3-methyl-aniline (2.56 g, 0.020 mol) in toluene (25 mL) was added dropwise over 35 minutes.", "After addition, the reaction mixture was stirred and refluxed for 1 hour.", "The reaction mixture was cooled to −50° C. and the solvent was removed in vacuo resulting in crude 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride.", "Part of this crude 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (0.63 g, 1.9 mmol) and 3-methyloxetan-3-yl)methanamine (212 mg, 2.1 mmol) were dissolved in dichloromethane (10 mL).", "Then diisopropylethylamine (820 μL, 4.8 mmol) was added and the resulting mixture was stirred for two hours.", "HCl (5 mL, aq/1M) was added to the mixture and the organic layer was separated and loaded directly on a silica plug purified by silica gel column chromatography using gradient elution from heptane to EtOAc (100:0 to 0:100).", "The desired fractions were concentrated in vacuo and dried in vacuo resulting in compound 7 (586 mg) as a white powder.", "Method A; Rt: 1.60 min.", "m/z: 394.0 (M−H)− Exact mass: 395.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.18-1.24 (s, 3H), 2.23 (d, J=1.8 Hz, 3H), 2.96 (s, 2H), 3.92 (s, 3H), 4.17 (d, J=5.8 Hz, 2H), 4.34 (d, J=5.8 Hz, 2H), 7.10 (t, J=9.2 Hz, 1H), 7.32 (d, J=1.8 Hz, 1H), 7.41-7.54 (m, 2H), 7.57 (d, J=1.8 Hz, 1H), 7.64 (dd, J=6.6, 2.2 Hz, 1H), 10.04 (s, 1H).", "Compound 8: N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Crude 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (obtained as described in the synthesis of compound 7, 0.5 g, 1.51 mmol) and (S)-1,1,1-trifluoro-2-propylamine (0.38 g, 3.33 mmol) were dissolved in of acetonitrile (9 mL).", "Then diisopropylethylamine (0.78 mL, 4.53 mmol) was added and the resulting mixture was stirred for two hours.", "HCl (5 mL, aq/1M) was added and the mixture was extracted using dichloromethane (3×25 mL) The combined extracts were dried on sodium sulphate, filtered and concentrated in vacuo.", "The residue was purified by silica gel column chromatography using gradient elution from heptane to EtOAc (100:0 to 0:100).", "The desired fractions were concentrated in vacuo and dried in vacuo resulting in compound 8 (557 mg) as a white powder.", "Method B; Rt: 1.03 min.", "m/z: 406.1 (M−H)− Exact mass: 407.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.08 (d, J=7.0 Hz, 3H), 2.23 (d, J=1.5 Hz, 3H), 3.83-4.01 (m, 4H), 7.10 (t, J=9.1 Hz, 1H), 7.33 (d, J=2.0 Hz, 1H), 7.47-7.55 (m, 1H), 7.57-7.69 (m, 2H), 8.15 (br.", "s., 1H), 9.90-10.13 (br.", "s., 1H).", "Columns: AD-H (250 mm×4.6 mm), Flow: 5 ml/min, Mobile phase: 25% MeOH (containing 0.2% iPrNH2) hold 4.00 min, up to 50% in 1 min and hold 2.00 min at 50%, Temperature: 40° C. Rt (compound 8): 1.2 min.", "Compound 9: N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Crude 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (obtained as described in the synthesis of compound 7, 0.69 g, 2.09 mmol), (R)-1,1,1-trifluoro-2-propylamine (472 mg, 4.2 mmol) and DIPEA (0.72 mL, 4.2 mmol) where stirred in a sealed tube at 55° C. for 16 hours.", "The reaction mixture was allowed to reach room temperature, and left for 4 hours.", "The solid was filtered off and washed with CH3CN (2×).", "The solvent of the filtrate was evaporated and the obtained residue was dissolved in CH2Cl2-heptane and then purified by silica gel column chromatography (heptane-EtOAc 100/0 to 0/100].", "The desired fractions were combined and the solvent removed in vacuo.", "The obtained residue was stirred in CH2Cl2 (5 mL), filtered and washed with CH2Cl2 (2×) resulting in compound 9 (0.244 g).", "Method A; Rt: 1.78 min.", "m/z: 408.1 (M+H)+ Exact mass: 407.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.08 (d, J=7.0 Hz, 3H), 2.23 (d, J=1.5 Hz, 3H), 3.87-3.96 (m, 4H), 7.10 (dd, J=9.2 Hz, 1H), 7.33 (d, J=1.8 Hz, 1H), 7.47-7.55 (m, 1H), 7.59-7.66 (m, 2H), 8.15 (br.", "s., 1H), 10.03 (s, 1H).", "Columns: AD-H (250 mm×4.6 mm), Flow: 5 ml/min, Mobile phase: 25% MeOH (containing 0.2% iPrNH2) hold 4.00 min, up to 50% in 1 min and hold 2.00 min at 50%, Temperature: 40° C. Rt (compound 9): 1.6 min.", "Compound 10: N-(4-fluoro-3-methyl-phenyl)-4-[[3-(hydroxymethyl)oxetan-3-yl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide DIPEA (1.44 mL, 0.008 mol) was added to a stirring mixture of crude 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (obtained as described in the synthesis of compound 7, 1.38 g, 0.0042 mol) and CH2Cl2 (45 mL).", "(3-aminooxetan-3-yl)methanol, 0.47 g, 0.0046 mol) was added, and the reaction mixture was stirred at room temperature for 16 hours.", "The volatiles were evaporated.", "The residue was stirred in EtOAc (50 mL) and washed with HCl 1M (25 mL).", "The separated organic layer was dried with Na2SO4, filtered off and evaporated.", "The obtained residue was dissolved in EtOAc (3 mL), and heptane (2 mL) was added.", "The resulting solution was left standing overnight.", "The formed precipitate was filtered off, washed with a minimum amount EtOAc (3×) and dried in vacuo.", "The obtained solid was recrystallized from CH3CN (20 mL) filtered off, washed with CH3CN (3×), and dried in vacuo, resulting in compound 10 (767 mg).", "Method A; Rt: 1.41 min.", "m/z: 395.9 (M−H)− Exact mass: 397.1.1H NMR (400 MHz, DMSO-d6) δ ppm 2.23 (d, J=1.8 Hz, 3H), 3.61 (d, J=5.7 Hz, 2H), 3.91 (s, 3H), 4.39 (d, J=6.4 Hz, 2H), 4.56 (d, J=6.4 Hz, 2H), 5.08 (t, J=5.6 Hz, 1H), 7.10 (t, J=9.2 Hz, 1H), 7.33 (d, J=2.0 Hz, 1H), 7.49-7.54 (m, 1H), 7.57 (d, J=1.8 Hz, 1H), 7.64 (dd=7.2, 2.3 Hz, 1H), 7.88 (s, 1H), 10.02 (s, 1H).", "Compound 11: N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[(3-methyltetrahydrofuran-3-yl)sulfamoyl]pyrrole-2-carboxamide Crude 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (obtained as described in the synthesis of compound 7, 690 mg) was stirred in CH2Cl2 (25 mL), 3-methyloxolan-3-amine hydrochloride (316 mg, 2.3 mmol) and DIPEA (0.9 mL, 5.2 mmol) were added and the mixture was stirred at room temperature for 17 hours.", "Ethylacetate (300 mL) was added and the mixture was washed with 0.5 M HCl (1×100 mL).", "The organic layer was dried with Na2SO4 and the solvent was evaporated.", "The obtained residue was purified by silica gel column chromatography Methanol/Dichloromethane 2/98 to 4/96].", "The desired fractions were combined and the solvent was evaporated.", "The mixture was repurified by silica gel column chromatography using EtOAc/Heptane 50/50 to 100/0].", "The desired fractions were combined and the solvent was evaporated.", "The obtained residue was recrystallized from 2-Propanol (7 mL).", "The obtained white solid was filtered off, washed with 2-Propanol (2×2 mL) and dried in vacuo, resulting in compound 11 (211 mg).", "Method A; Rt: 1.62 min.", "m/z: 394.1 (M−H)− Exact mass: 395.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.29 (s, 3H), 1.73 (dt, J=12.7, 7.3 Hz, 1H), 2.11-2.28 (m, 4H), 3.39 (d, J=8.6 Hz, 1H), 3.66-3.79 (m, 3H), 3.91 (s, 3H), 7.09 (t, J=9.2 Hz, 1H), 7.31 (d, J=1.8 Hz, 1H), 7.46-7.56 (m, 3H), 7.64 (dd, J=7.0, 2.2 Hz, 1H), 10.02 (s, 1H).", "Compound 12: N-(4-fluoro-3-methyl-phenyl)-4-[[1-(hydroxymethyl)cyclopropyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide Compound 12 was prepared similarly as described for compound 11, using 1-amino-cyclopropanemethanol instead of 3-methyloxolan-3-amine hydrochloride.", "After work up, the obtained solid was stirred in boiling CH2Cl2 and filtered off.", "The obtained white solid was recrystallized from Acetonitrile, resulting in compound 12 (1.021 g).", "Method B; Rt: 0.84 min.", "m/z: 380.1 (M−H)− Exact mass: 381.1.1H NMR (360 MHz, DMSO-d6) δ ppm 0.54-0.65 (m, 4H), 2.23 (d, J=1.8 Hz, 3H), 3.37 (d, J=5.9 Hz, 2H), 3.90 (s, 3H), 4.59 (t, J=5.9 Hz, 1H), 7.10 (t, J=9.1 Hz, 1H), 7.27 (d, J=1.8 Hz, 1H), 7.49-7.55 (m, 2H), 7.65 (dd, J=7.1, 2.4 Hz, 1H), 7.75 (s, 1H), 10.03 (s, 1H).", "Compound 13: N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[(1-methyl-5-oxo-pyrrolidin-3-yl)sulfamoyl]pyrrole-2-carboxamide Compound 13 was prepared similarly as described for compound 7, using 4-amino-1-methyl-pyrrolidin-2-one hydrochloride instead of 3-methyloxetan-3-yl)methanamine.", "Method B; Rt: 0.81 min.", "m/z: 409.1 (M+H)+ Exact mass: 408.1.1H NMR (400 MHz, DMSO-d6) δ ppm 2.07-2.15 (m, 1H), 2.23 (d, J=1.8 Hz, 3H), 2.35-2.50 (m, 1H), 2.67 (s, 3H), 3.18 (dd, J=10.1, 4.6 Hz, 1H), 3.52 (dd, J=10.1, 7.3 Hz, 1H), 3.76-3.85 (m, 1H), 3.92 (s, 3H), 7.10 (t, J=9.2 Hz, 1H), 7.31 (d, J=2.0 Hz, 1H), 7.46-7.55 (m, 1H), 7.58 (d, J=1.8 Hz, 1H), 7.64 (dd, J=7.0, 2.6 Hz, 1H), 7.72 (br.", "s, 1H), 10.03 (s, 1H).", "Compound 13, was separated in it's enantiomers compound 13a and compound 13b by preparative SFC (Stationary phase: Chiralpak Daicel IC 20×250 mm), Mobile phase: CO2, MeOH with 0.4% iPrNH2) The desired fractions were concentrated in vacuo and dried in vacuo yielding compound 13a (192 mg) and compound 13b (200 mg) as white powders.", "Columns: ID-H (diacel) 250 mm×4.6 mm, Flow: 5 mL/min.", "Mobile phase: 30% MeOH (containing 0.2% iPrNH2) hold 4.00 min, up to 50% in 1 min and hold 2.00 min at 50%.", "Temperature: 40° C. Rt: 13a: 2.2 min; 13b 2.5 min.", "Compound 14: N-(4-fluoro-3-methyl-phenyl)-4-[[3-(2-hydroxyethyl)oxetan-3-yl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide Compound 14 was prepared similarly as described for compound 7, using 2-(3-aminooxetan-3-yl)ethanol instead of 3-methyloxetan-3-yl)methanamine, resulting in compound 14 (1.09 g) as a white powder.", "Method B; Rt: 0.80 min.", "m/z: 410.1 (M−H)− Exact mass: 411.1.1H NMR (400 MHz, DMSO-d6) δ ppm 2.14 (t, J=6.6 Hz, 2H), 2.23 (d, J=1.5 Hz, 3H), 3.42-3.50 (m, 2H), 3.91 (s, 3H), 4.32 (d, J=6.4 Hz, 2H), 4.45 (br.", "s, 1H), 4.56 (d, J=6.4 Hz, 2H), 7.10 (t, J=9.1 Hz, 1H), 7.33 (d, J=1.8 Hz, 1H), 7.46-7.54 (m, 1H), 7.56 (d, J=1.8 Hz, 1H), 7.63 (dd, J=7.0, 2.4 Hz, 1H), 7.84 (br.", "s., 1H), 10.02 (s, 1H).", "Compound 15: N-(4-fluoro-3-methyl-phenyl)-4-[(3-hydroxycyclobutyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (0.56 g, 1.7 mmol) was stirred in CH2Cl2 (15 mL).", "cis-3-aminocyclobutanol hydrochloride (0.23 g, 1.9 mmol) and DIPEA (1.5 mL, 8.5 mmol) were added at room temperature and the mixture was stirred for 60 hour.", "The solvent was evaporated and the obtained residue was purified by silica gel column chromatography (Methanol/Dichloromethane 2/98 to 4/96).", "The pure fractions were combined and the solvent was evaporated and the obtained residue was crystallized from dichloromethane, resulting in compound 15 (273 mg) as a white solid after filtration and drying in vacuo.", "Method B; Rt: 0.81 min.", "m/z: 380.1 (M−H)− Exact mass: 381.1 1H NMR (360 MHz, DMSO-d6) δ ppm 1.59-1.71 (m, 2H), 2.22 (d, J=1.5 Hz, 3H), 2.28-2.38 (m, 2H), 3.02-3.16 (m, 1H), 3.63-3.75 (m, 1H), 3.90 (s, 3H), 5.02 (d, J=5.9 Hz, 1H), 7.10 (dd, J=9.1 Hz, 1H), 7.28 (d, J=1.8 Hz, 1H), 7.47-7.55 (m, 3H), 7.65 (dd, J=7.1, 2.4 Hz, 1H), 10.03 (s, 1H).", "Compound 16: 4-(tert-butylsulfamoyl)-N-(4-fluoro-3-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (0.60 g, 1.8 mmol) was stirred in CH2Cl2 (15 mL).", "tert-butylamine (0.23 g, 1.9 mmol) and DIPEA (0.8 mL, 4.5 mmol) were added at room temperature and the mixture was stirred for 18 hours.", "The solvent was evaporated and EtOAc (50 mL) was added.", "After washing with 1M HCl (20 mL), the organic layer was dried with Na2SO4 and the solvent was evaporated.", "The obtained solid was dissolved in dichloromethane (10 mL) and the solvent was slowly evaporated at 50° C. The evaporation was stopped when precipitation commenced, and stirring was continued at room temperature for 15 minutes.", "The precipitate was filtered off, washed with dichloromethane (1 mL) and dried in vacuo at 50° C., resulting in compound 16 (136 mg).", "Method A; Rt: 1.79 min.", "m/z: 366.1 (M−H)− Exact mass: 367.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (s, 9H), 2.23 (d, J=1.5 Hz, 3H), 3.90 (s, 3H), 7.05-7.13 (m, 2H), 7.29 (d, J=1.8 Hz, 1H), 7.45-7.55 (m, 2H), 7.64 (dd, J=7.0, 2.2 Hz, 1H), 10.00 (s, 1H).", "Compound 17: 4-[[3-(cyanomethyl)oxetan-3-yl]sulfamoyl]-N-(4-fluoro-3-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide Compound 10 (0.46 g, 1.2 mmol) was dissolved in dry dichloromethane (30 mL) and dry DIPEA (0.31 mL, 1.8 mmol) was added.", "This mixture was cooled in an ice bath and stirred for 20 minutes.", "Then Methanesulfonyl Chloride (0.10 mL, 1.3 mmol) in dry dichloromethane (10 mL) was added dropwise over 10 minutes, after stirring 30 minutes more at 0° C., the mixture was washed with 0.5 M HCl (50 mL) and saturated aqueous NaHCO3 (5 mL).", "The water layer was extracted with EtOAc (200 mL) and the combined organic layers were dried with Na2SO4.The solvent was removed in vacuo and the obtained residue was dissolved in dry DMSO.", "This solution was added dropwise to a solution of sodium cyanide (0.12 g, 2.4 mmol) in dry DMSO (25 mL) at 40° C. The mixture was stirred 2.5 hour at 40° C. After cooling to room temperature water (50 mL) was added.", "This mixture was extracted with diethylether (3×100 mL) and EtOAc (3×150 mL).", "The combined organic layer were dried on Na2SO4 and the solvent was evaporated.", "The obtained residue was purified by silica gel column chromatography by gradient elution with EtOAc/Heptane 0/100 to 100/0].", "The desired fractions were combined and the solvent was removed, resulting compound 17 (264 mg) as a beige solid after drying in vacuo.", "Method B; Rt: 0.86 min.", "m/z: 405.2 (M−H)− Exact mass: 406.1 1H NMR (360 MHz, DMSO-d6) δ ppm 2.23 (d, J=1.8 Hz, 3H), 3.28 (s, 2H), 3.91 (s, 3H), 4.28 (d, J=7.0 Hz, 2H), 4.55 (d, J=7.0 Hz, 2H), 7.11 (t, J=9.3 Hz, 1H), 7.35 (d, J=2.2 Hz, 1H), 7.47-7.55 (m, 1H), 7.61-7.67 (m, 2H), 8.46-8.53 (m, 1H), 10.05 (s, 1H).", "Compound 18: 4-[[1-(cyanomethyl)cyclopropyl]sulfamoyl]-N-(4-fluoro-3-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide Prepared similarly as described for compound 17, starting from compound 12 instead of compound 10.Method C; Rt: 1.69 min.", "m/z: 389.1 (M−H)− Exact mass: 390.1.1H NMR (360 MHz, CHLOROFORM-d) δ ppm 0.63-0.74 (m, 4H), 2.23 (d, J=1.8 Hz, 3H), 2.81 (s, 2H), 3.92 (s, 3H), 7.07-7.15 (m, 1H), 7.26-7.31 (m, 1H), 7.49-7.59 (m, 2H), 7.62-7.68 (m, 1H), 8.13-8.20 (m, 1H), 10.02-10.09 (m, 1H).", "Compound 19: 4-(tert-butylsulfamoyl)-N-(3,4-difluorophenyl)-1-methyl-pyrrole-2-carboxamide A solution of 3,4-difluoroaniline (1.9 mL, 19.2 mmol) in toluene (20 mL) was added dropwise (over 15 minutes) to a refluxing solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonylchloride in toluene (250 mL).", "After the addition, the reaction mixture was left to stir at reflux for 1 hour.", "The reaction mixture was left to cool to room temperature under nitrogen atmosphere while stirring.", "The grey suspension was concentrated and the obtained residue containing 5-[(3,4-difluorophenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride was dried in vacuo and further used without further purification.", "Tert-butylamine (0.3 mL, 2.8 mmol) was added to a suspension of crude 5-[(3,4-difluorophenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (1.2 g, 2.55 mmol) in dry dichloromethane (20 mL) at room temperature.", "Next, NEt3 (0.9 mL, 6.4 mmol) was added dropwise and the reaction mixture was stirred at room temperature for 1 hour and at 50° C. for 1.5 hour.", "The reaction mixture was diluted with EtOAc (250 mL).", "0.5 N HCl (30 mL) was added to the reaction mixture and the layers were separated.", "The organic layer was washed again with 0.5 N NaOH (30 mL), followed by water.", "The organic layer was dried on MgSO4, filtered and evaporated.", "The obtained residue was purified by silica gel column chromatography (eluent: CH2Cl2:MeOH 100:0->95:5).", "The obtained white solid was triturated in a small amount of CH2Cl2.After filtration, washing with CH2Cl2 and drying in vacuo, compound 19 (310 mg) was obtained as a white solid.", "Method B; Rt: 1.02 min.", "m/z: 370.1 (M−H)− Exact mass: 371.1.1H NMR (360 MHz, DMSO-d6) δ ppm 1.16 (s, 9H) 3.90 (s, 3H) 7.16 (s, 1H) 7.31 (d, J=1.8 Hz, 1H) 7.35-7.46 (m, 1H) 7.45-7.53 (m, 1H) 7.54 (d, J=1.5 Hz, 1H) 7.88 (ddd, J=13.5, 7.8, 2.2 Hz, 1H) 10.24 (s, 1H).", "Compound 20: N-(3,4-difluorophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide Compound 20 was prepared similarly as described for compound 19, using 3-methyl-3-oxetanamine hydrochloride instead of tert-butylamine.", "After work-up the obtained residue was triturated in a small amount of CH2Cl2 and filtered resulting in a white powder.", "The powder was triturated in EtOAc (1 mL), filtered and rinsed with a small amount of CH2Cl2 resulting in compound 20 (421 mg) as a white powder after drying in vacuo.", "Method B; Rt: 0.86 min.", "m/z: 384.1 (M−H)− Exact mass: 385.1.1H NMR (360 MHz, DMSO-d6) δ ppm 1.54 (s, 3H) 3.91 (s, 3H) 4.13 (d, J=6.2 Hz, 2H) 4.59 (d, J=6.2 Hz, 2H) 7.33 (d, J=1.8 Hz, 1H) 7.37-7.46 (m, 1H) 7.46-7.52 (m, 1H) 7.61 (d, J=1.8 Hz, 1H) 7.87 (ddd, J=13.5, 7.4, 2.6 Hz, 1H) 8.00 (s, 1H) 10.25 (s, 1H).", "Compound 21: N-(3,4-difluorophenyl)-1-methyl-4-[[(3S)-tetrahydrofuran-3-yl]-sulfamoyl]pyrrole-2-carboxamide A solution of 3,4-difluoroaniline in toluene (50 mL) was slowly added (over 1 hour) to a refluxing solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonylchloride in toluene (200 mL).", "After addition, the reaction mixture was left to stir at reflux for 45 minutes.", "The reaction mixture was left to cool to room temperature under nitrogen atmosphere while stirring and was then cooled with an ice bath.", "The precipitate was filtered and the filtrate was concentrated and dried in vacuo, resulting in a residue containing 5-[(3,4-difluorophenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride.", "(S)-3-aminotetrahydrofuran tosylate (0.59 g, 2.3 mmol) was added to a suspension of 5-[(3,4-difluorophenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (1.0 g of the above obtained crude) in dry dichloromethane (50 mL) at room temperature.", "NEt3 (0.72 mL, 5.2 mmol) was added dropwise and the mixture was further stirred at room temperature for 1 hour.", "0.5 N HCl (30 mL) was added to the reaction mixture and the layers were separated.", "The organic layer was washed again with 0.5 N NaOH (30 mL) followed by water.", "The organic layer was dried on MgSO4 and was evaporated.", "The obtained residue was triturated in a small amount of CH2Cl2, filtered, and washed with a small amount of CH2Cl2, resulting in compound 21 (408 mg) as a white solid, after drying in vacuo.", "Method B; Rt: 0.84 min m/z: 384.0 (M−H)− Exact mass: 385.1.1H NMR (360 MHz, DMSO-d6) δ ppm 1.66-1.76 (m, 1H) 1.91-2.03 (m, 1H) 3.40-3.47 (m, 1H) 3.61 (td, J=8.1, 5.9 Hz, 1H) 3.65-3.75 (m, 3H) 3.92 (s, 3H) 7.33 (d, J=1.83 Hz, 1H) 7.37-7.46 (m, 1H) 7.46-7.52 (m, 1H) 7.57-7.62 (m, 2H) 7.88 (ddd, J=13.5, 7.6, 2.4 Hz, 1H) 10.26 (s, 1H).", "Compound 22: N-(3,4-difluorophenyl)-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide Compound 22 was prepared similarly as described for compound 21, using isopropylamine instead of (S)-3-aminotetrahydrofuran tosylate.", "After work-up (only 0.5 N HCl was used for washing) the obtained residue was purified by silica gel column chromatography (CH2Cl2:MeOH 100:0->95:5) resulting in compound 22 (534 mg) as a white solid after drying in vacuo.", "Method B; Rt: 0.94 min.", "m/z: 356.1 (M−H)− Exact mass: 357.1.1H NMR (360 MHz, DMSO-d6) δ ppm 1.01 (d, J=6.2 Hz, 6H) 3.18-3.28 (m, 1H) 3.91 (s, 3H) 7.23 (d, J=7.0 Hz, 1H) 7.32 (d, J=1.8 Hz, 1H) 7.36-7.46 (m, 1H) 7.46-7.53 (m, 1H) 7.56 (d, J=1.8 Hz, 1H) 7.88 (ddd, J=13.4, 7.5, 2.6 Hz, 1H) 10.25 (s, 1H).", "Compound 23: N-(3,4-difluorophenyl)-1-methyl-4-[[(1R)-1-methylpropyl]sulfamoyl]pyrrole-2-carboxamide Compound 23 was prepared similarly as described for compound 22, using (R)-(−)-2-aminobutane instead of isopropylamine.", "After work up, the obtained residue was triturated in a small amount of CH2Cl2, filtered and washed with a small amount of CH2Cl2.The obtained solid was triturated with 0.5 N NaOH and filtered.", "The white solid was washed with water resulting in compound 23 (499 mg) as a white solid, after drying in vacuo.", "Method B; Rt: 1.00 min.", "m/z: 370.1 (M−H)− Exact mass: 371.1.1H NMR (360 MHz, DMSO-d6) δ ppm 0.76 (t, J=7.5 Hz, 3H) 0.95 (d, J=6.6 Hz, 3H) 1.28-1.41 (m, 2H) 3.00-3.13 (m, 1H) 3.91 (s, 3H) 7.18 (d, J=7.7 Hz, 1H) 7.32 (d, J=1.8 Hz, 1H) 7.36-7.46 (m, 1H) 7.46-7.53 (m, 1H) 7.56 (d, J=1.8 Hz, 1H) 7.88 (ddd, J=13.4, 7.7, 2.4 Hz, 1H) 10.25 (s, 1H).", "Compound 24: N-(3,4-difluorophenyl)-4-[[(1R)-2-hydroxy-1-methyl-ethyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide Compound 24 was prepared similarly as described for compound 19, using D-alaninol instead of tert-butylamine, using 5 equiv of NEt3 and 1.5 hour stirring at room temperature.", "The reaction mixture was diluted with EtOAc (250 mL), 0.5 N HCl (30 mL) was added to the reaction mixture and the layers were separated.", "The organic layer was washed again with 0.5 N NaOH (30 mL) followed by water.", "The organic layer was dried on MgSO4, filtered and evaporated.", "The obtained residue was triturated in a small amount of CH2Cl2, filtered and washed with a small amount of CH2Cl2 resulting in compound 24 (717 mg) as a white powder, after drying in vacuo.", "Method B; Rt: 0.81 min.", "m/z: 372.0 (M−H)− Exact mass: 373.1 1H NMR (360 MHz, DMSO-d6) δ ppm 0.97 (d, J=5.9 Hz, 3H) 3.06-3.17 (m, 2H) 3.32-3.39 (m, 1H), 3.91 (s, 3H) 4.69 (t, J=5.3 Hz, 1H) 7.14 (d, J=6.6 Hz, 1H) 7.32 (d, J=1.5 Hz, 1H) 7.36-7.46 (m, 1H) 7.46-7.53 (m, 1H) 7.57 (d, J=1.5 Hz, 1H) 7.88 (ddd, J=13.5, 7.6, 2.4 Hz, 1H) 10.25 (s, 1H).", "Compound 25: N-(3,4-difluorophenyl)-4-[(3-hydroxycyclobutyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide Compound 25 was prepared similarly as described for compound 19, using cis-3-amino-cyclobutanol hydrochloride instead of tert-butylamine and adding 2.5 equiv more NEt3 before heating to 50° C. The residue obtained after work up was triturated in a small amount of CH2Cl2, filtered and washed with a small amount of CH2Cl2 resulting in a white powder, which was further triturated in MeOH/CH2Cl2 5/95.After filtration, washing and drying in vacuo, compound 25 (150 mg) was obtained as a white powder.", "Method A; Rt: 0.80 min.", "m/z: 384.0 (M−H)− Exact mass: 385.1.1H NMR (360 MHz, DMSO-d6) δ ppm 1.59-1.71 (m, 2H) 2.27-2.39 (m, 2H) 3.03-3.15 (m, 1H) 3.64-3.76 (m, 1H) 3.91 (s, 3H) 5.02 (d, J=5.5 Hz, 1H) 7.28-7.33 (m, 1H) 7.36-7.46 (m, 1H) 7.46-7.57 (m, 2H) 7.88 (ddd, J=13.5, 7.6, 2.0 Hz, 1H) 10.24 (s, 1H).", "Compound 91: N-(3,4-Difluorophenyl)-1-methyl-4-[(3-methyltetrahydrofuran-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 91 was prepared similarly as described for compound 19 using 3-methyloxolan-3-amine hydrochloride instead of tert-butylamine.", "Compound 91 (206 mg) was obtained as a white solid.", "Method B; Rt: 0.91 min.", "m/z: 398.1 (M−H)− Exact mass: 399.1.1H NMR (360 MHz, DMSO-d6) ppm 1.28 (s, 3H) 1.72 (dt, J=12.5, 7.5 Hz, 1H) 2.12-2.21 (m, 1H) 3.38 (d, J=8.8 Hz, 1H) 3.69-3.75 (m, 3H) 3.91 (s, 3H) 7.33 (d, J=2.2 Hz, 1H) 7.36-7.46 (m, 1H) 7.46-7.52 (m, 1H) 7.55-7.59 (m, 2H) 7.88 (ddd, J=13.4, 7.6, 2.4 Hz, 1H) 10.25 (s, 1H).", "Compound 92: N-(3,4-Difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]-sulfamoyl}-1H-pyrrole-2-carboxamide Compound 92 was prepared similarly as described for compound 19 using (R)-1,1,1-trifluoro-2-propylamine instead of tert-butylamine.", "Compound 92 precipitated from the basic 0.5 N NaOH water layer upon neutralization.", "Compound 92 was further purified by Preparative HPLC (Stationary phase: Uptisphere C18 ODB—10 μm, 200 g, 5 cm), Mobile phase: 0.5% NH4OAc solution in water+10% CH3CN, CH3CN).", "The collected fractions were concentrated (to the aqueous phase).", "The aqueous phase was acidified with HCl 1N and was extracted with EtOAc.", "The organic layer was dried on MgSO4, filtered, and evaporated resulting in compound 92 (49 mg) as a white solid after drying in vacuo at 50° C. Method B; Rt: 1.03 min.", "m/z: 410.1 (M−H)− Exact mass: 411.1.1H (360 MHz, DMSO-d6) δ ppm 1.06 (d, J=7.0 Hz, 3H) 3.92 (s, 3H) 3.87-4.00 (m, 1H) 7.35 (d, J=1.8 Hz, 1H) 7.37-7.52 (m, 2H) 7.66 (d, J=1.8 Hz, 1H) 7.88 (ddd, J=13.4, 7.6, 2.4 Hz, 1H) 8.18 (d, J=8.8 Hz, 1H) 10.27 (s, 1H).", "Compound 93: N-(3,4-Difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 93 was prepared similarly as described for compound 92 using (S)-1,1,1-trifluoro-2-propylamine instead of (R)-1,1,1-trifluoro-2-propylamine.", "Method B; Rt: 1.03 min.", "m/z: 410.1 (M−H)− Exact mass: 411.1.Alternative Synthesis of Compound 92: Methyl 1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (6.61 g, 21.0 mmol) and 3,4-difluoroaniline (3.26 g, 25.24 mmol) were dissolved in tetrahydrofuran (150 mL) and this was stirred and cooled in an ice-water bath.", "Lithium bis(trimethylsilyl)amide in toluene (63.1 mL, 1 M, 63.1 mmol) was added dropwise over a period of 5 minutes.", "The resulting mixture was stirred for 1 h while cooling was continued.", "Another two equivalents of lithium bis(trimethylsilyl)amide in toluene (42.06 mL, 1 M, 42.06 mmol) were added and the resulting mixture was stirred for 2 hours at room temperature.", "The resulting mixture was quenched using ammonium chloride (sat./200 mL).", "The resulting mixture was extracted using EtOAc (3×250 mL).", "The combined extracts were washed with brine (250 mL), dried on Na2SO4, filtered and concentrated in vacuo yielding a brown powder.", "This was crystallised twice out of methanol/water.", "The precipitation was collected on a glass filter.", "The obtained powder was purified by silica gel column chromatography using gradient elution from heptane to EtOAc.", "(100:0 to 0:100) and next by silica gel column chromatography using gradient elution from dichloromethane to MeOH (100:0 to 99:1).", "The desired fractions were concentrated in vacuo yielding a powder.", "The obtained residue was crystallized out of methanol/water.", "The white crystals were collected on a glass filter and dried in a vacuum oven at 55° C. for 24 hours yielding compound 92 (4.32 g) as white needles.", "[α]36520=−11.6° (c 0.85 w/v %, MeOH).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 219.6° C. Compound 95: N-(3,4-Difluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)-sulfamoyl]-1H-pyrrole-2-carboxamide 5-[(3,4-difluorophenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (648 mg, 1.374 mmol), 2,2,2-trifluoro-1,1-dimethyl-ethylamine (262 mg), DIPEA (0.296 mL, 1.72 mmol) in acetonitrile (65 mL) was refluxed overnight.", "2,2,2-trifluoro-1,1-dimethyl-ethylamine (349 mg) were added and the reaction mixture was refluxed over weekend.", "The reaction mixture was concentrated.", "The residue was dissolved in EtOAc (100 mL), washed with 1M HCl, dried over sodium sulphate, filtered and concentrated.", "The obtained residue was subjected to silica gel column chromatography using a gradient from 10 to 100% EtOAc in heptane.", "The pure fractions were collected, concentrated and dried in vacuo at 50° C. yielding compound 95 as a white powder (162 mg).", "Method A; Rt: 1.78 min.", "m/z: 424.1 (M−H)− Exact mass: 425.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.36 (s, 6H), 3.92 (s, 3H), 7.32 (d, J=1.8 Hz, 1H), 7.36-7.45 (m, 1H), 7.46-7.52 (m, 1H), 7.58 (d, J=1.8 Hz, 1H), 7.87 (ddd, J=13.4, 7.6, 2.5 Hz, 1H), 8.04 (s, 1H), 10.25 (s, 1H).", "Compound 26: 1-methyl-4-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]-N-(3,4,5-trifluoro-phenyl)pyrrole-2-carboxamide A solution of 3,4,5-trifluoroaniline (0.99 g, 6.7 mmol) in toluene (20 mL) was added dropwise to a refluxing solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonylchloride in toluene (80 mL).", "After the addition, the reaction mixture was left to stir at reflux for 1 hour.", "The mixture was cooled and concentrated in vacuo.", "The obtained crude containing 1-methyl-5-[(3,4,5-trifluorophenyl)carbamoyl]pyrrole-3-sulfonyl chloride was used a such.", "A solution of (S)-(−)-3-aminotetrahydrofuran p-toluenesulfonate (647 mg, 2.5 mmol) and DIPEA (0.98 mL, 5.7 mmol) in CH2Cl2 (10 mL) was added to crude 1-methyl-5-[(3,4,5-trifluorophenyl)carbamoyl]pyrrole-3-sulfonyl chloride (800 mg) in CH2Cl2 (150 mL) and stirred for 1 hour.", "The mixture was diluted with dichloromethane (400 mL) and washed with 1M HCl (2×), water and saturated NaHCO3 solution.", "The organic layer was dried over magnesium sulphate, filtered and concentrated.", "The obtained residue was dissolved in hot MeOH (100 mL) and water was added.", "The formed white precipitate was filtered off, dried in vacuo and purified by silica gel column chromatography using a gradient from 20 to 100% EtOAc in heptane.", "The product fractions were concentrated and dried in vacuo resulting in compound 26 (286 mg) as a white powder.", "Method A; Rt: 1.67 min.", "m/z: 401.9 (M−H)− Exact mass: 403.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.66-1.76 (m, 1H), 1.91-2.03 (m, 1H), 3.39-3.47 (m, 1H), 3.55-3.65 (m, 1H), 3.65-3.75 (m, 3H), 3.92 (s, 3H), 7.33 (d, J=2.0 Hz, 1H), 7.58 (d, J=5.5 Hz, 1H), 7.61 (d, J=1.5 Hz, 1H), 7.63-7.71 (m, 2H), 10.33 (s, 1H).", "Compound 27: 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-N-(3,4,5-trifluorophenyl)pyrrole-2-carboxamide 3-methyl-3-oxetanamine hydrochloride (526 mg, 4.3 mmol) and DIPEA (1.8 mL) were dissolved in CH2Cl2 (5 mL).", "Crude 1-methyl-5-[(3,4,5-trifluorophenyl)carbamoyl]pyrrole-3-sulfonyl chloride (1.2 g, obtained as described for compound 26) was added and the reaction mixture was stirred for 30 minutes.", "The reaction mixture was directly loaded on silica gel column and purified by gradient elution from heptane to EtOAc, yielding compound 27 (758 mg) as a white powder after trituration in CH2Cl2 and drying in vacuo.", "Method A; Rt: 1.68 min.", "m/z: 401.9 (M−H)− Exact mass: 403.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (s, 3H), 3.92 (s, 3H), 4.14 (d, J=6.5 Hz, 2H), 4.60 (d, J=6.1 Hz, 2H), 7.34 (d, J=1.6 Hz, 1H), 7.62 (d, J=2.0 Hz, 1H), 7.66 (dd, J=10.3, 6.7 Hz, 2H), 7.98 (s, 1H), 10.32 (s, 1H).", "DSC: From 30 to 300° C. at 10° C./min, Peak: 218° C. Compound 28:1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-N-[3-(trifluoromethyl)-phenyl]pyrrole-2-carboxamide 3-(trifluoromethyl)aniline (0.41 mL, 3.3 mmol) was added dropwise to a refluxing solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonylchloride in toluene (25 mL).", "After the addition, the reaction mixture was left to stir at reflux for 4 hours.", "The mixture was cooled to room temperature and a solution of 3-methyl-3-oxetanamine hydrochloride (408 mg, 3.3 mmol) and DIPEA (0.57 mL) in CH2Cl2 (2 mL) was added.", "The mixture was stirred overnight at room temperature.", "More 3-methyl-3-oxetanamine hydrochloride (0.5 equiv) and DIPEA (0.5 equiv) in CH2Cl2 (2 mL) were added and the mixture was stirred for 2 hours at room temperature and 2 hours more at 50° C. The reaction mixture was allowed to reach room temperature and the formed precipitate was filtered off, triturated in MeOH (12 mL), filtered and dried in vacuo, resulting in compound 28 as a white powder.", "Method B; Rt: 0.99 min.", "m/z: 416.1 (M−H)− Exact mass: 417.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.55 (s, 3H), 3.93 (s, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.39 (d, J=2.0 Hz, 1H), 7.43 (d, J=7.7 Hz, 1H), 7.58 (t, J=8.0 Hz, 1H), 7.61 (d, J=1.8 Hz, 1H), 7.95-8.02 (m, 2H), 8.19 (s, 1H), 10.32 (s, 1H).", "Compound 29: 1-ethyl-N-(4-fluoro-3-methyl-phenyl)-4-(isopropylsulfamoyl)pyrrole-2-carboxamide To 4-chlorosulfonyl-1-ethyl-pyrrole-2-carboxylic acid (1 g, commercial from enamine, EN300-43738, 4.2 mmol) in CH2Cl2, (10 mL) at room temperature under N2-atmosphere, DMF (1 drop) was added followed by dropwise addition of a solution of oxalyl chloride (1.44 mL, 0.0168 mol) in CH2Cl2 (5 mL) over 10 minutes.", "After addition, the reaction mixture as stirred at room temperature for 24 hours.", "The volatiles were evaporated, and co-evaporated with dry toluene (2×).", "The obtained residue containing 4-chlorosulfonyl-1-ethyl-pyrrole-2-carbonyl chloride was used as such in the next step.", "A solution of 4-fluoro-3-methylaniline (527 mg, 4.2 mmol) in toluene was added dropwise to a solution of the above obtained crude 4-chlorosulfonyl-1-ethyl-pyrrole-2-carbonyl chloride in toluene at reflux over 5 minutes.", "The reaction mixture was refluxed 30 minutes and next allowed to reach room temperature.", "After stirring at room temperature for 2 hours the volatiles were removed in vacuo resulting in a residue containing 1-ethyl-5-[(4-fluoro-3-methyl-phenyl)carbamoyl]pyrrole-3-sulfonyl chloride that was used as such in the next step.", "Part of the as such obtained crude 1-ethyl-5-[(4-fluoro-3-methyl-phenyl)carbamoyl]pyrrole-3-sulfonyl chloride (708 mg) was dissolved in CH2Cl2 (5 mL) and isopropylamine (0.13 mL, 1.6 mmol) and DIPEA (0.72 mL, 4.2 mmol) were added and the reaction mixture stirred at room temperature for 30 minutes.", "The mixture was diluted with EtOAc (100 mL) and washed with 1 M HCl (2×10 mL).", "The organic layer was dried on Na2SO4, filtered and concentrated resulting in a residue that was purified using silica gel column chromatography (ethyl acetate in heptane from 10 to 100%) resulting in compound 29 (270 mg).", "Method B; Rt: 1.02 min.", "m/z: 366.2 (M−H)− Exact mass: 367.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.01 (d, J=6.6 Hz, 6H), 1.31 (t, J=7.0 Hz, 3H), 2.23 (d, J=1.5 Hz, 3H), 3.20-3.33 (m, 1H), 4.38 (q, J=7.0 Hz, 2H), 7.09 (t, J=9.1 Hz, 1H), 7.16 (d, J=7.0 Hz, 1H), 7.29 (d, J=1.8 Hz, 1H), 7.48-7.54 (m, 1H), 7.57 (d, J=1.8 Hz, 1H), 7.64 (dd, J=7.0, 2.4 Hz, 1H), 10.03 (br.", "s, 1H).", "Compound 30: 1-ethyl-N-(4-fluoro-3-methyl-phenyl)-4-[[(3S)-tetrahydrofuran-3-yl]-sulfamoyl]pyrrole-2-carboxamide Crude 1-ethyl-5-[(4-fluoro-3-methyl-phenyl)carbamoyl]pyrrole-3-sulfonyl chloride (obtained as described for compound 29) was dissolved in CH2Cl2 (5 mL) and (S)-(−)-3-aminotetrahydrofuran p-toluenesulfonate (410 mg, 1.6 mmol)) and DIPEA (0.7 mL, 4.2 mmol) were added and the reaction mixture stirred at room temperature for 30 minutes.", "The mixture was diluted with EtOAc (100 mL) and washed with 1M HCl (2×10 mL).", "The organic layer was dried (Na2SO4), filtered and concentrated in vacuo to afford a residue that was purified using silica gel column chromatography (ethyl acetate in heptane from 10 to 100%) resulting in compound 30 (282 mg) as white powder after drying in vacuo.", "Method B; Rt: 0.92 min.", "m/z: 394.1 (M−H)− Exact mass: 395.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.32 (t, J=7.0 Hz, 3H), 1.64-1.75 (m, 1H), 1.90-2.02 (m, 1H), 2.23 (d, J=1.5 Hz, 3H), 3.36-3.45 (m, 1H), 3.61 (td, J=8.0, 5.9 Hz, 1H), 3.66-3.78 (m, 3H), 4.39 (q, J=7.1 Hz, 2H), 7.09 (t, J=9.1 Hz, 1H), 7.30 (d, J=1.8 Hz, 1H), 7.46-7.56 (m, 2H), 7.61 (d, J=1.8 Hz, 1H), 7.64 (dd, J=7.0, 2.4 Hz, 1H), 10.04 (br.", "s, 1H).", "Compound 31: N-(4-fluoro-3,5-dimethyl-phenyl)-1-methyl-4-[[(3S)-tetrahydrofuran-3-yl]-sulfamoyl]pyrrole-2-carboxamide 4-fluoro-3,5-dimethyl-benzenamine (995 mg, 7.1 mmol) dissolved in toluene (20 mL) was added dropwise to a solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonylchloride (1.7 g) in toluene (100 mL) at reflux.", "The reaction mixture was refluxed 1 hour and next allowed to cool to room temperature.", "(S)-(−)-3-aminotetrahydrofuran p-toluenesulfonate (2.0 g, 7.9 mmol) and DIPEA (3.1 mL, 17.9 mmol) dissolved in CH2Cl2 (50 mL) was added, the reaction mixture was stirred for 1 hour and then concentrated in vacuo.", "The obtained residue was dissolved in EtOAc (300 mL), washed with 1 M HCl (2×), water and saturated NaHCO3.The solution was dried over magnesium sulphate, filtered and concentrated.", "The obtained residue was purified by silica gel column chromatography (gradient from 20 till 100% EtOAc in heptanes).", "The product fractions were concentrated and the obtained residue was recrystallized from hot EtOAc (100 mL) upon addition of heptane.", "The white crystals were filtered off and dried in vacuo resulting in compound 31 (1.7 g) as a white powder.", "Method A; Rt: 1.68 min.", "m/z: 393.9 (M−H)− Exact mass: 395.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.66-1.77 (m, 1H), 1.92-2.03 (m, 1H), 2.21 (d, J=2.0 Hz, 6H), 3.40-3.47 (m, 1H), 3.61 (td, J=8.1, 5.9 Hz, 1H), 3.66-3.76 (m, 3H), 3.91 (s, 3H), 7.31 (d, J=2.0 Hz, 1H), 7.43 (d, J=6.8 Hz, 2H), 7.50-7.58 (m, 2H), 9.94 (s, 1H).", "Compound 32: N-(3-fluoro-5-methyl-phenyl)-1-methyl-4-[[(3S)-tetrahydrofuran-3-yl]-sulfamoyl]pyrrole-2-carboxamide Compound 32 was prepared similarly as described for compound 31, using 3-fluoro-5-methylaniline instead of 4-fluoro-3,5-dimethyl-benzenamine.", "After silica gel column chromatography (EtOAc in heptanes 20% to 100%), compound 32 (2.2 g) was obtained as a white powder.", "Method A; Rt: 1.62 min.", "m/z: 379.9 (M−H)− Exact mass: 381.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.66-1.77 (m, 1H), 1.92-2.03 (m, 1H), 2.30 (s, 3H), 3.40-3.47 (m, 1H), 3.61 (td, J=8.0, 5.9 Hz, 1H), 3.66-3.76 (m, 3H), 3.92 (s, 3H), 6.75 (d, J=9.7 Hz, 1H), 7.34 (d, J=1.8 Hz, 1H), 7.35-7.38 (m, 1H), 7.47 (d, J=11.7 Hz, 1H), 7.55 (d, J=5.5 Hz, 1H), 7.58 (d, J=1.8 Hz, 1H), 10.12 (s, 1H).", "Compound 33: N-(3,4-difluoro-5-methyl-phenyl)-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide 3,4-difluoro-5-methylbenzoic acid (Alfa Aesar, H32313-03, 4.8 g, 26.9 mmol) was dissolved in t-BuOH (100 mL).", "NEt3 (4.1 mL, 29.6 mmol) was added followed by diphenylphosphoryl azide (7.5 g, 27.4 mmol) and the reaction mixture was refluxed overnight.", "The mixture was concentrated and the obtained residue was purified by silica gel column chromatography using a gradient from 30 till 100% EtOAc in heptane.", "The product fractions were concentrated in vacuo yielding tert-butyl N-(3,4-difluoro-5-methyl-phenyl)carbamate (4.15 g) as a white powder.", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.47 (s, 9H), 2.22 (d, J=1.8 Hz, 3H), 7.11 (d, J=5.1 Hz, 1H), 7.26-7.38 (m, 1H), 9.47 (br.", "s., 1H).", "To a tert-butyl N-(3,4-difluoro-5-methyl-phenyl)carbamate (4.15 g) in CH2Cl2 (100 mL), HCl (6M in iPrOH, 13.7 mL) was added and the mixture was stirred for 3 hours.", "The reaction mixture was concentrated in vacuo.", "The white solid residue was dissolved in water (100 mL), alkalinized with 1M NaOH and extracted with ether.", "The organic layer was dried over MgSO4, filtered and concentrated yielding 3,4-difluoro-5-methyl-aniline as a colorless oil which was stored under nitrogen in the dark and used a such.", "1H NMR (400 MHz, DMSO-d6) δ ppm 2.13 (d, J=2.2 Hz, 3H), 5.11 (s, 2H), 6.16-6.23 (m, 1H), 6.31 (ddd, J=12.9, 6.5, 2.8 Hz, 1H).", "3,4-difluoro-5-methyl-aniline (209 mg, 1.5 mmol) dissolved in toluene (20 mL) was added dropwise to a solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonylchloride (353 mg) in toluene (30 mL) at reflux.", "The reaction mixture was refluxed 2 hours, allowed to cool to room temperature and concentrated in vacuo.", "Isopropylamine (216 mg, 3.7 mmol) dissolved in CH2Cl2 (50 mL) was added and the reaction mixture was stirred overnight and next concentrated in vacuo.", "The obtained residue was dissolved in hot methanol (100 mL) and H2O was added.", "The formed precipitate was filtered off and dried in vacuo, resulting in compound 33 (385 mg).", "Method A; Rt: 1.83 min.", "m/z: 370.0 (M−H)− Exact mass: 371.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.02 (d, J=6.4 Hz, 6H), 2.28 (d, J=2.0 Hz, 3H), 3.21-3.30 (m, 1H), 3.91 (s, 3H), 7.19 (d, J=7.0 Hz, 1H), 7.31 (d, J=1.8 Hz, 1H), 7.41 (d, J=5.9 Hz, 1H), 7.54 (d, J=1.8 Hz, 1H), 7.66 (ddd, J=12.9, 7.1, 2.4 Hz, 1H), 10.13 (s, 1H).", "Compound 34: N-(3,4-difluoro-5-methyl-phenyl)-1-methyl-4-[[(1R)-1-methylpropyl]-sulfamoyl]pyrrole-2-carboxamide Compound 34 (1.18 g) was prepared similarly as described for compound 33, using (R)-(−)-2-aminobutane instead of iPrNH2.Method A; Rt: 1.87 min.", "m/z: 384.1 (M−H)− Exact mass: 385.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.76 (t, J=7.4 Hz, 3H), 0.96 (d, J=6.6 Hz, 3H), 1.29-1.42 (m, 2H), 2.28 (d, J=1.8 Hz, 3H), 3.00-3.12 (m, 1H), 3.91 (s, 3H), 7.15 (d, J=7.7 Hz, 1H), 7.32 (d, J=2.0 Hz, 1H), 7.42 (d, J=5.7 Hz, 1H), 7.54 (d, J=1.8 Hz, 1H), 7.67 (ddd, J=13.0, 7.0, 2.4 Hz, 1H), 10.11 (s, 1H).", "Compound 35: N-(3,4-difluoro-5-methyl-phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)-sulfamoyl]pyrrole-2-carboxamide 3,4-difluoro-5-methyl-aniline (600 mg, 4.2 mmol) dissolved in toluene (20 mL) was added dropwise to a solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonylchloride (1.0 g) in toluene (50 mL) at reflux.", "The reaction mixture was refluxed 2 hour, allowed to cool to room temperature and concentrated in vacuo.", "A mixture of 3-methyl-3-oxetanamine hydrochloride (570 mg, 4.6 mmol) and DIPEA (1.8 mL, 10.5 mmol) dissolved in CH2Cl2 (100 mL) was added and the reaction mixture was stirred overnight and next concentrated in vacuo.", "The obtained residue was dissolved in hot methanol (200 mL) and H2O was added.", "The formed precipitate was filtered off and dried in vacuo, resulting in compound 35 (1.1 g) as a white powder.", "Method A; Rt: 1.66 min.", "m/z: 398.1 (M−H)− Exact mass: 399.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (s, 3H), 2.28 (d, J=2.0 Hz, 3H), 3.91 (s, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.33 (d, J=1.8 Hz, 1H), 7.41 (d, J=5.9 Hz, 1H), 7.59 (d, J=1.8 Hz, 1H), 7.66 (ddd, J=12.9, 7.0, 2.5 Hz, 1H), 7.96 (s, 1H), 10.13 (s, 1H).", "Compound 36: N-(3,4-difluoro-5-methyl-phenyl)-4-[[(1R)-2-hydroxy-1-methyl-ethyl]-sulfamoyl]-1-methyl-pyrrole-2-carboxamide 3,4-difluoro-5-methyl-aniline (600 mg, 4.2 mmol) dissolved in toluene (20 mL) was added dropwise to a solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonylchloride (353 mg) in toluene (100 mL) at reflux.", "The reaction mixture was refluxed 2 hours, allowed to cool to room temperature and concentrated in vacuo.", "D-alaninol (787 mg, 10.5 mmol) in CH2Cl2 (100 mL) was added, followed by CH3CN (50 mL) and the reaction mixture was stirred overnight and next concentrated in vacuo.", "The obtained residue was dissolved in warm methanol (50 mL) and H2O was added.", "The formed precipitate was filtered off and dried in vacuo, resulting in compound 36 (1.16 g).", "Method A; Rt: 1.57 min.", "m/z: 386.0 (M−H)− Exact mass: 387.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.98 (d, J=6.2 Hz, 3H), 2.28 (d, J=2.0 Hz, 3H), 3.07-3.20 (m, 2H), 3.32-3.39 (m, 1H), 3.91 (s, 3H), 4.65 (t, J=5.5 Hz, 1H), 7.10 (d, J=6.8 Hz, 1H), 7.32 (d, J=2.0 Hz, 1H), 7.42 (d, J=5.9 Hz, 1H), 7.55 (d, J=1.8 Hz, 1H), 7.66 (ddd, J=12.9, 7.0, 2.5 Hz, 1H), 10.13 (s, 1H).", "Compound 37: N-(3,4-difluoro-5-methyl-phenyl)-1-methyl-4-[[(3S)-tetrahydrofuran-3-yl]-sulfamoyl]pyrrole-2-carboxamide Compound 37 was prepared similarly as described for compound 35, using (S)-(−)-3-aminotetrahydrofuran p-toluenesulfonate instead of 3-methyl-3-oxetanamine hydrochloride.", "After reaction, the obtained residue was dissolved in EtOAc (300 mL), washed with 1M HCl (2×), water and saturated NaHCO3.The solution was dried over magnesium sulphate, filtered and concentrated.", "The obtained residue was recrystallized from hot methanol (50 mL) upon addition of water.", "Compound 37 (464 mg) was obtained as white fluffy crystals after drying in vacuo.", "Method A; Rt: 1.65 min.", "m/z: 398.1 (M−H)− Exact mass: 399.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.66-1.77 (m, 1H), 1.90-2.03 (m, 1H), 2.28 (d, J=1.8 Hz, 3H), 3.40-3.47 (m, 1H), 3.61 (td, J=8.0, 5.9 Hz, 1H), 3.66-3.76 (m, 3H), 3.92 (s, 3H), 7.33 (d, J=2.0 Hz, 1H), 7.41 (d, J=5.9 Hz, 1H), 7.56 (d, J=5.5 Hz, 1H), 7.58 (d, J=1.8 Hz, 1H), 7.66 (ddd, J=12.9, 7.0, 2.5 Hz, 1H), 10.14 (s, 1H).", "Compound 38: 4-(tert-butylsulfamoyl)-N-(3,4-difluoro-5-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide Compound 38 (399 mg) was prepared similarly as described for compound 33, using tert-butylamine instead of iPrNH2.Method A; Rt: 1.86 min.", "m/z: 384.1 (M−H)− Exact mass: 385.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (s, 9H), 2.28 (d, J=2.0 Hz, 3H), 3.90 (s, 3H), 7.11 (s, 1H), 7.31 (d, J=1.8 Hz, 1H), 7.38-7.44 (m, 1H), 7.52 (d, J=1.5 Hz, 1H), 7.66 (ddd, J=1.0 Hz, 1H), 10.11 (s, 1H).", "Compound 39: N-[3-(difluoromethyl)-4-fluoro-phenyl]-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide To 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonylchloride (1.6 g) in toluene (100 mL) at reflux, 3-(difluoromethyl)-4-fluoro-aniline (1 equiv) was added dropwise (0.1 mL/min).", "After addition, the mixture was further refluxed for 15 minutes.", "The reaction mixture, containing 5-[[3-(difluoromethyl)-4-fluoro-phenyl]carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride was allowed to reach room temperature and was used as such in the next step.", "To half of the above obtained solution containing 5-[[3-(difluoromethyl)-4-fluoro-phenyl]carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride, 3-methyl-3-oxetanamine hydrochloride (449 mg, 3.6 mmol) and DIPEA (1.14 mL, 6.6 mmol) dissolved in CH2Cl2 (5 mL) were added and the reaction mixture was stirred overnight.", "More DIPEA (1.14 mL, 6.6 mmol) was added and the mixture was stirred over weekend.", "The volatiles were removed under reduced pressure and the residue was purified on silica using a heptane to EtOAc gradient yielding compound 39 (681 mg) as a white powder.", "Method C; Rt: 1.60 min.", "m/z: 416.1 (M−H)− Exact mass: 417.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.55 (s, 3H), 3.92 (s, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.22 (t, J=54.4 Hz, 1H), 7.32-7.40 (m, 2H), 7.59 (d, J=1.8 Hz, 1H), 7.84-7.93 (m, 1H), 7.96 (s, 1H), 8.05 (dd, J=6.3, 2.5 Hz, 1H), 10.25 (s, 1H).", "Compound 40: N-[3-(difluoromethyl)-4-fluoro-phenyl]-4-[[(1R)-2-hydroxy-1-methyl-ethyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide Compound 40 (670 mg) was prepared similarly as described for compound 39 using D-alaninol instead of 3-methyl-3-oxetanamine hydrochloride.", "Method C; Rt: 1.50 min.", "m/z: 404.0 (M−H)− Exact mass: 405.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.98 (d, J=6.2 Hz, 3H), 3.05-3.21 (m, 2H), 3.33-3.38 (m, 1H), 3.92 (s, 3H), 4.66 (t, J=5.5 Hz, 1H), 7.10 (d, J=6.8 Hz, 1H), 7.22 (t, J=54.4 Hz, 1H), 7.34 (d, J=2.0 Hz, 1H), 7.36 (t, J=9.5 Hz, 1H), 7.56 (d, J=1.5 Hz, 1H), 7.89 (dd, J=8.8, 3.3 Hz, 1H), 8.06 (dd, J=6.3, 2.5 Hz, 1H), 10.26 (s, 1H).", "Compound 41: N-[4-fluoro-3-(trifluoromethyl)phenyl]-4-[[(1R)-2-hydroxy-1-methyl-ethyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide Compound 41 (376 mg) was prepared similarly as described for compound 40 using 4-fluoro-3-(trifluoromethyl)aniline instead of 3-(difluoromethyl)-4-fluoro-aniline.", "Method B; Rt: 0.93 min.", "m/z: (M−H)− Exact mass: 423.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.98 (d, J=6.2 Hz, 3H), 3.07-3.20 (m, 2H), 3.34-3.39 (m, 1H), 3.92 (s, 3H), 4.66 (t, J=5.5 Hz, 1H), 7.11 (d, J=6.8 Hz, 1H), 7.35 (d, J=1.8 Hz, 1H), 7.50 (t, J=9.9 Hz, 1H), 7.57 (d, J=1.8 Hz, 1H), 7.99-8.08 (m, 1H), 8.20 (dd, J=6.6, 2.6 Hz, 1H), 10.34 (s, 1H).", "Compound 42: N-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-4-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]pyrrole-2-carboxamide Compound 42 (569 mg) was prepared similarly as described for compound 41, using (S)-(−)-3-aminotetrahydrofuran-4-toluene-sulfonate instead of D-alaninol.", "Method C; Rt: 1.77 min.", "m/z: 434.1 (M−H)− Exact mass: 435.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.67-1.77 (m, 1H), 1.91-2.04 (m, 1H), 3.40-3.48 (m, 1H), 3.61 (td, J=8.0, 5.9 Hz, 1H), 3.66-3.77 (m, 3H), 3.93 (s, 3H), 7.36 (d, J=2.0 Hz, 1H), 7.50 (t, J=9.8 Hz, 1H), 7.57 (d, J=5.7 Hz, 1H), 7.60 (d, J=1.8 Hz, 1H), 7.99-8.07 (m, 1H), 8.20 (dd, J=6.4, 2.6 Hz, 1H), 10.35 (s, 1H).", "Compound 43: N-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-4-[(3-methyloxetan-3-yl)-sulfamoyl]pyrrole-2-carboxamide Compound 43 (164 mg) was prepared similarly as described for compound 41, using 3-methyl-3-oxetanamine hydrochloride instead of D-alaninol.", "After silica gel column chromatography, the compound was recrystallized from MeOH.", "Method A; Rt: 1.73 min.", "m/z: 434.0 (M−H)− Exact mass: 435.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.55 (s, 3H), 3.92 (s, 3H), 4.14 (d, J=6.2 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.36 (d, J=2.0 Hz, 1H), 7.50 (t, J=9.8 Hz, 1H), 7.61 (d, J=1.8 Hz, 1H), 7.97 (s, 1H), 7.99-8.07 (m, 1H), 8.20 (dd, J=6.5, 2.5 Hz, 1H), 10.34 (s, 1H).", "Compound 44: N-[4-fluoro-3-(trifluoromethyl)phenyl]-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide Compound 44 (146 mg) was prepared similarly as described for compound 41, using isopropylamine instead of D-alaninol.", "After silica gel column chromatography, the compound triturated with MeOH and diisopropylether, resulting in compound 44 as a white solid.", "Method B; Rt: 1.06 min.", "m/z: 406.1 (M−H)− Exact mass: 407.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.02 (d, J=6.6 Hz, 6H), 3.22-3.29 (m, 1H), 3.92 (s, 3H), 7.20 (d, J=7.0 Hz, 1H), 7.35 (d, J=2.0 Hz, 1H), 7.50 (t, J=9.8 Hz, 1H), 7.56 (d, J=1.5 Hz, 1H), 7.98-8.07 (m, 1H), 8.20 (dd, J=6.4, 2.6 Hz, 1H), 10.33 (s, 1H).", "Compound 45: N-[3-fluoro-5-(trifluoromethyl)phenyl]-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonylchloride (800 mg) was dissolved in toluene (25 mL) and brought to reflux.", "3-amino-5-fluorobenzotrifluoride (592 mg, 3.3 mmol) was added dropwise.", "After addition the reaction was refluxed for 4 hours.", "The reaction mixture was allowed to reach room temperature and 3-methyl-3-oxetanamine hydrochloride (408 mg, 3.3 mmol) and DIPEA (1.4 mL, 8.3 mmol) dissolved in CH2Cl2 (2 mL) were added and the reaction mixture was stirred overnight.", "More 3-methyl-3-oxetanamine hydrochloride (0.5 equiv) and DIPEA (0.5 equiv) in CH2Cl2 (2 mL) was added and the reaction mixture was stirred 2 hours more.", "The reaction mixture was brought to 50° C. and stirred for 2 hours.", "The volatiles were removed under reduced pressure and the residue was redissolved in EtOAc (30 mL).", "The formed precipitates were filtered off and the filtrate was evaporated to dryness.", "The obtained residue was triturated in MeOH (15 mL), filtered and dried in vacuo, yielding compound 45 (704 mg) as a white powder.", "Method B; Rt: 1.05 min.", "m/z: 434.2 (M−H) Exact mass: 435.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.55 (s, 3H), 3.93 (s, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.60 (d, J=6.2 Hz, 2H), 7.37 (d, J=8.6 Hz, 1H), 7.40 (d, J=2.0 Hz, 1H), 7.64 (d, J=1.8 Hz, 1H), 7.91-8.02 (m, 3H), 10.46 (s, 1H).", "Compound 46: N-(3-bromo-4,5-difluoro-phenyl)-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide 3-bromo-4,5-difluoroaniline (2.6 g, 12.8 mmol) in toluene (20 mL) was added dropwise to a solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonylchloride (3100 mg, 12.8 mmol) in toluene (160 mL) at reflux.", "The reaction mixture was refluxed 2 hours and next allowed to cool to room temperature.", "To one third of the above mixture containing 5-[(3-bromo-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride, Isopropylamine (7.3 mL, 85.4 mmol) and DIPEA (2.2 mL, 12.8 mmol) in CH2Cl2 (70 mL) was added.", "The reaction mixture was stirred at room temperature.", "After a few seconds the homogeneous mixture became a suspension.", "The solids were filtered, washed with CH2Cl2 (4 mL) and dried overnight in vacuo resulting in compound 46 (1.02 g) as an off white powder.", "Method B; Rt: 1.10 min.", "m/z: 436.1 (M−H)− Exact mass: 437.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.02 (d, J=6.6 Hz, 6H), 3.14-3.30 (m, 1H), 3.92 (s, 3H), 7.22 (d, J=7.0 Hz, 1H), 7.33 (d, J=1.8 Hz, 1H), 7.57 (d, J=1.8 Hz, 1H), 7.74-7.95 (m, 2H), 10.27 (s, 1H).", "Compound 47: N-(3-bromo-4,5-difluoro-phenyl)-1-methyl-4-[[(1R)-1-methylpropyl]-sulfamoyl]pyrrole-2-carboxamide Compound 47 was prepared similarly as described for compound 46 using (R)-(−)-2-aminobutane (4 equiv) instead of isopropylamine.", "After addition of (R)-(−)-2-aminobutane, the mixture was stirred overnight.", "The solid was filtered, washed with CH2Cl2 and dried in vacuo, resulting in compound 47 (1.17 g) as an off-white solid.", "Method B; Rt: 1.15 min.", "m/z: 448.0 (M−H)− Exact mass: 449.0.1H NMR (400 MHz, DMSO-d6) δ ppm 0.76 (t, J=7.5 Hz, 3H), 0.96 (d, J=6.6 Hz, 3H), 1.24-1.46 (m, 2H), 3.07 (spt, J=6.7 Hz, 1H), 3.91 (s, 3H), 7.17 (d, J=7.5 Hz, 1H), 7.33 (d, J=1.8 Hz, 1H), 7.57 (d, J=1.8 Hz, 1H), 7.78-7.95 (m, 2H), 10.26 (s, 1H).", "Compound 48: N-(3-bromo-4,5-difluoro-phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)-sulfamoyl]pyrrole-2-carboxamide Compound 48 was prepared similarly as described for compound 46 using 3-methyl-3-oxetanamine (4 equiv) instead of isopropylamine.", "After addition of 3-methyl-3-oxetanamine, the mixture was stirred for 5 days.", "The formed precipitate was filtered, washed with CH2Cl2 and dried in vacuo, resulting in compound 48 (707 mg) as an off white powder.", "Method B; Rt: 1.00 min.", "m/z: 464.0 (M−H)− Exact mass: 465.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (s, 3H), 3.92 (s, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.59 (d, J=6.2 Hz, 2H), 7.35 (d, J=2.0 Hz, 1H), 7.62 (d, J=1.8 Hz, 1H), 7.84 (td, J=6.3, 2.5 Hz, 1H), 7.89 (ddd, J=7.7, 5.1, 2.4 Hz, 1H), 7.98 (br.", "s., 1H), 10.28 (br.", "s., 1H).", "Compound 49: methyl 2-[[5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrol-3-yl]sulfonylamino]-2-methyl-propanoate 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (1.96 g) was stirred in CH2Cl2 (90 mL).", "DIPEA (1.0 mL, 5.9 mmol) and alpha-aminoisobutyric acid methyl ester hydrochloride (1 g, 6.5 mmol) were added under N2-atmosphere at room temperature.", "The reaction mixture was stirred for 3 hour.", "More DIPEA (2 mL) was added and the reaction mixture was stirred for 80 hours.", "Next, the reaction mixture was washed with 1M HCl (100 mL).", "The organic layer was dried on Na2SO4.After evaporation of the solvent, the residue was purified by silica gel column chromatography (EtOAc/Heptane 0/100 to 100/0).", "The desired fractions were combined, the solvent was evaporated and the obtained solid dried in vacuo.", "Compound 49 (1.6 g) was obtained as a white solid.", "Method A; Rt: 1.70 min.", "m/z: 410.1 (M−H)− Exact mass: 411.1.1H NMR (360 MHz, DMSO-d6) δ ppm 1.35 (s, 6H), 2.23 (d, J=1.1 Hz, 3H), 3.54 (s, 3H), 3.90 (s, 3H), 7.10 (t, J=9.1 Hz, 1H), 7.29 (d, J=1.5 Hz, 1H), 7.48-7.56 (m, 2H), 7.65 (dd, J=7.0, 2.6 Hz, 1H), 7.85 (s, 1H), 10.04 (s, 1H).", "Synthesis of 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxylic acid Chlorosulfonic acid (80 mL) was cooled to 0° C. and methyl 1-methylpyrrole-2-carboxylate (20 g, 143.73 mmol) was added dropwise.", "After addition, the mixture was allowed to reach room temperature and stirred for another hour.", "The resulting mixture was added drop wise to a mechanically stirred, temperature controlled, ice-water mixture (1500 mL) keeping the temperature under 5° C. A white precipitation was formed.", "The obtained aqueous mixture was extracted using dichloromethane (3×500 mL).", "The combined extracts were dried on sodium sulphate, filtered and concentrated in vacuo yielding methyl 4-(chlorosulfonyl)-1-methyl-1H-pyrrole-2-carboxylate (29.4 g) as a white powder which was used as such.", "Methyl 4-(chlorosulfonyl)-1-methyl-1H-pyrrole-2-carboxylate (5 g, 1.04 mmol) was dissolved in acetonitrile (50 mL).", "diisopropylethylamine (9.06 mL, 52.6 mmol) was added, followed by 3-methyl-3-oxetanamine (1.92 g, 22.1 mmol) and the resulting mixture was refluxed for 2 hours.", "Then, the mixture was cooled to room temperature and concentrated in vacuo.", "The resulting residue was dissolved in dichloromethane (250 mL) and this was washed with HCl (2×150 mL).", "The organics were dried on sodium sulphate, filtered and concentrated in vacuo yielding methyl 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxylate (6.07 g) as a beige powder which was used as such.", "Method B; Rt: 0.63 min.", "m/z: 287.1 (M−H)− Exact mass: 288.1.Methyl 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxylate (6.07 g, 21.05 mmol) was dissolved in tetrahydrofuran (60 mL).", "Lithium hydroxide (0.76 g, 31.58 mmol) in distilled water (8 mL) was added, followed by methanol (3 mL).", "The resulting mixture was stirred for 72 hours.", "Next, it was concentrated until only water remained and extra distilled water (15 mL) was added.", "After neutralization with hydrochloric acid (1M/aq/31.6 mL, 31.58 mmol).", "The resulting mixture was extracted using 2-methyltetrahydrofuran (3×20 mL).", "The combined extracts were dried on sodium sulphate, filtered and concentrated in vacuo yielding 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxylic acid (5.77 g) as a bright white powder which was used as such.", "Method B; Rt: 0.26 min.", "m/z: 273.1 (M−H)− Exact mass: 274.1 Compound 50: N-(3-cyano-4-fluorophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide A tube was charged with 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxylic acid (0.25 g, 0.91 mmol) and HATU (0.36 g, 0.96 mmol).", "N,N-dimethylformamide (1 mL) and diisopropylethylamine (0.47 mL, 2.73 mmol) were added and the mixture was stirred for 30 minutes.", "Next, 5-amino-2-fluorobenzonitrile (0.26 g, 1.82 mmol) was added at once and the resulting mixture was stirred at room temperature for 2 hours.", "The resulting mixture was added to distilled water (10 mL) under stirring and the mixture was allowed to stir for 1 hour.", "A precipitation was formed which was collected on a filter and dried in vacuo, yielding compound 50 (0.25 g) as a white powder.", "Method B; Rt: 0.83 min.", "m/z: 391.1 (M−H)− Exact mass: 392.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (s, 3H), 3.92 (s, 3H), 4.14 (d, J=6.2 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.35 (d, J=1.5 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.61 (d, J=1.5 Hz, 1H), 7.93-8.07 (m, 2H), 8.21 (dd, J=5.7, 2.6 Hz, 1H), 10.36 (s, 1H).", "Compound 51: N-[4-cyano-3-(trifluoromethyl)phenyl]-1-methyl-4-[(3-methyloxetan-3-yl)-sulfamoyl]-1H-pyrrole-2-carboxamide A tube was charged with 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxylic acid (0.2 g, 0.73 mmol) and HATU (0.29 g, 0.77 mmol).", "N,N-dimethylformamide (1 mL) and diisopropylethylamine 0.38 mL, 2.19 mmol) were added and the mixture was stirred for 30 minutes.", "To this was added 4-amino-2-(trifluoromethyl)benzonitrile (0.27 g, 1.46 mmol) at once and the resulting mixture was stirred at room temperature for 2 hours.", "The resulting mixture was added to distilled water (10 mL) under stirring.", "The resulting mixture was allowed to stir for 1 hour and then it was extracted using 2-methyl tetrahydrofuran (3×20 mL).", "The combined extracts were dried on sodium sulphate, filtered and concentrated in vacuo.", "The obtained crude was dissolved in dichloromethane (3 mL) and loaded directly on a silica plug.", "This was purified using column chromatography (gradient elution EtOAc/heptane 0:100 to 100:0) The desired fractions were concentrated in vacuo and dried in vacuo, resulting in compound 51 (18.1 mg) as a bright white powder.", "Method A; Rt: 1.67 min.", "m/z: 440.9 (M−H) Exact mass: 442.1 1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (s, 3H), 3.94 (s, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.41-7.46 (m, 1H), 7.62-7.68 (m, 1H), 8.00 (br.", "s., 1H), 8.07-8.14 (m, 1H), 8.16-8.23 (m, 1H), 8.34-8.45 (m, 1H), 10.69 (br.", "s., 1H).", "Compound 52: N-(3-cyano-4,5-difluoro-phenyl)-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide A degassed suspension of compound 46 (400 mg, 0.917 mmol), Zn(CN)2 (93.0 mg, 0.79 mmol) and tetrakis(triphenylphosphine)palladium (57.3 mg, 0.050 mmol) in DMF (3 mL) was stirred at 75° C. overnight.", "The mixture was cooled to room temperature and the solids were filtered off and washed with DMF (2 mL).", "The filtrate was then poured into water (50 mL).", "The precipitates were filtered and washed with water to afford an off white powder.", "This solid was purified using silica gel column chromatography (ethyl acetate in heptane from 0 to 50%) to afford a white powder (310 mg).", "This white powder is purified using Prep.", "LCMS.", "(Hypersyl C18 BDS-3 μm, 100×4.6 mm) Mobile phase (NH4HCO3 0.2% in water, methanol) the desired fractions were combined and evaporated to dryness, dissolved in methanol again and evaporated to dryness and dried in vacuo to afford compound 52 (27.8 mg) as a white powder.", "Method B; Rt: 1.01 min.", "m/z: 381.1 (M−H)− Exact mass: 382.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.02 (d, J=6.6 Hz, 6H), 3.20-3.30 (m, 1H), 3.92 (s, 3H), 7.23 (br.", "s., 1H), 7.34 (d, J=1.8 Hz, 1H), 7.59 (d, J=1.8 Hz, 1H), 7.98 (dt, J=4.6, 2.2 Hz, 1H), 8.14 (ddd, J=12.9, 7.5, 2.5 Hz, 1H), 10.47 (br.", "s., 1H).", "Compound 53: 4-(tert-butylsulfamoyl)-N-(3-cyano-5-fluoro-phenyl)-1-methyl-pyrrole-2-carboxamide 5-amino-3-fluorobenzonitrile (1034 mg, 7.6 mmol) dissolved in toluene (10 mL) was added dropwise during 5 minutes to a solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride (1839 mg, 7.6 mmol) in toluene (190 mL) at reflux.", "The reaction mixture was refluxed 3 hours and concentrated in vacuo yielding crude 5-[(3-cyano-5-fluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride as a brown powder which was used as such.", "(2.74 g).", "1H NMR (400 MHz, acetonitrile-d3) δ ppm 3.97 (s, 3H), 7.24-7.29 (m, 1H), 7.42 (d, J=2.0 Hz, 1H), 7.75 (d, J=1.8 Hz, 1H), 7.79-7.86 (m, 2H), 8.93 (br.", "s, 1H).", "A solution of 5-[(3-cyano-5-fluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (892 mg, 2.48 mmol) and tert-butylamine (544 mg, 7.44 mmol) in acetonitrile (100 mL) were stirred overnight.", "Water was added until crystallisation started.", "The crystals were filtered of and dried overnight in vacuo at 50° C., resulting in compound 53 (631 mg) Method A, Rt: 1.74 min m/z: 377.1 (M−H)− Exact mass: 378.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (s, 9H), 3.92 (s, 3H), 7.15 (s, 1H), 7.37 (d, J=2.0 Hz, 1H), 7.52-7.56 (m, 1H), 7.57 (d, J=1.8 Hz, 1H), 7.96 (d, J=11.2 Hz, 1H), 7.99-8.01 (m, 1H), 10.44 (s, 1H).", "Compound 54: N-(3-cyano-5-fluoro-phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)-sulfamoyl]pyrrole-2-carboxamide A solution of 5-[(3-cyano-5-fluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (924 mg, 2.57 mmol) and 3-methyl-3-oxetanamine (559 mg, 6.4 mmol) in acetonitrile (100 mL) was stirred overnight.", "Water was added until crystallisation started.", "The crystals were filtered of and dried overnight in vacuo at 50° C., resulting in compound 54 (630 mg) Method A, Rt: 1.52 min m/z: 391.1 (M−H)− Exact mass: 392.1 1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (s, 3H), 3.93 (s, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.38 (d, J=2.0 Hz, 1H), 7.52-7.58 (m, 1H), 7.64 (d, J=1.5 Hz, 1H), 7.93-7.98 (m, 1H), 7.98-8.01 (m, 2H), 10.46 (s, 1H).", "Compound 55: N-(3-cyanophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide 3-aminobenzonitrile (360 mg, 3.0 mmol) dissolved in toluene (10 mL) was added dropwise to a solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride (752 mg, 3.1 mmol) in toluene (90 mL) at reflux.", "The reaction mixture was refluxed 2.5 hours, decanted hot and concentrated in vacuo yielding crude 5-[(3-cyanophenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride.", "A solution of 3-methyloxetan-3-amine (0.271 g, 3.11 mmol) in CH3CN (10 mL, p.a.", "dried on molecular sieves) was added to a stirring solution of 5-[(3-cyanophenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (1.00 g, 3.11 mmol) in CH3CN (40 mL, p.a.", "dried on molecular sieves).", "DIPEA (1.07 mL, 6.21 mol) was added, and the reaction mixture was stirred at room temperature for 18 hours.", "The volatiles were evaporated.", "The residue was purified by silica gel column chromatography using EtOAc-heptane 0/100 to 100/0 as eluent.", "The desired fractions were combined and evaporated.", "The residue was stirred in CH2Cl2 (4 mL), filtered off, washed with CH2Cl2 (3×), and dried in vacuo at 50° C., resulting in compound 55 (0.43 g).", "Method A; Rt: 1.42 min.", "m/z: 373.0 (M−H)− Exact mass: 374.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.55 (s, 3H), 3.93 (s, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.38 (d, J=2.0 Hz, 1H), 7.50-7.59 (m, 2H), 7.61 (d, J=1.5 Hz, 1H), 7.85-8.10 (m, 2H), 8.16-8.24 (m, 1H), 10.00-10.67 (m, 1H).", "Compound 56: N-(2,6-dideuterio-4-fluoro-3-methyl-phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide 4-fluoro-3-methyl-aniline (1386 mg, 11.075 mmol), 1M DCl (2075 mg, 11.075 mmol) in 11 mL D2O was heated in the microwave at 180° C. during 30 minutes.", "The reaction mixture was diluted with distilled water (50 mL), alkalanised with 1M NaOH, diluted with brine until product separates as oil and extracted with Et2O.", "The organic layer was dried over magnesium sulphate, filtered and concentrated yielding 2,6-dideuterio-4-fluoro-3-methyl-aniline (1068 mg) as a light brown colored oil which used as such.", "1H NMR (400 MHz, DMSO-d6) δ ppm 2.09 (d, J=2.0 Hz, 3H), 4.79 (br.", "s., 2H), 6.75 (d, J=9.9 Hz, 1H).", "2,6-dideuterio-4-fluoro-3-methyl-aniline (1068 mg, 8.40 mmol) dissolved in toluene (10 mL) was added dropwise during 5 minutes to a solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride (2033 mg, 8.40 mmol) in toluene (210 mL) at reflux.", "The reaction mixture was refluxed 90 minutes and concentrated in vacuo yielding crude 5-[(2,6-dideuterio-4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride as a grey powder which was used as such.", "(2810 mg).", "Method A; Rt: 1.91 min m/z: 331.0 (M−H)− Exact mass: 332.0.1H NMR (400 MHz, CHLOROFORM-d) δ ppm 2.30 (d, J=2.0 Hz, 3H), 4.05 (s, 3H), 7.01 (d, J=9.2 Hz, 1H), 7.14 (d, J=1.8 Hz, 1H), 7.50 (d, J=1.5 Hz, 1H), 7.57 (br.", "s., 1H).", "3-methyl-3-oxetanamine (491 mg, 5.63 mmol) and DIPEA (0.97 mL, 5.63 mmol) were added to a solution of 5-[(2,6-dideuterio-4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (750 mg, 2.25 mmol) in dichloromethane (100 mL) and stirred overnight and concentrated in vacuo at 50° C. The residue was dissolved in EtOAc (150 mL), washed twice with 1M HCl, water and saturated NaHCO3 solution.", "The solution was dried over sodium sulphate, filtered and concentrated.", "The residue was dissolved in warm EtOAc (75 mL) and the product crystallized upon addition of heptane (350 mL) The white crystals were filtered off and dried overnight in vacuo at 50° C., resulting in compound 56 (532 mg).", "Method A, Rt: 1.56 min m/z: 382.1 (M−H)− Exact mass: 383.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.55 (s, 3H), 2.23 (d, J=2.0 Hz, 3H), 3.91 (s, 3H), 4.13 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.09 (d, J=9.5 Hz, 1H), 7.32 (d, J=2.0 Hz, 1H), 7.56 (d, J=1.8 Hz, 1H), 7.94 (s, 1H), 10.02 (s, 1H).", "Compound 57: N-(3-chloro-4,5-difluoro-phenyl)-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide 3-chloro-4,5-difluorobenzoic acid (1011 mg, 52.5 mmol) was dissolved in tert-butyl alcohol (200 mL).", "Triethylamine (8 mL, 57.8 mmol) was added followed by diphenylphosphoryl azide (14.74 g, 53.6 mmol) and the reaction mixture was refluxed overnight.", "The reaction mixture was concentrated and purified by column chromatography on silica using a gradient from 10 till 100% EtOAc in heptane and again with 10% CH2Cl2 in heptane till 100% CH2Cl2.The product fractions were concentrated in vacuo yielding tert-butyl N-(3-chloro-4,5-difluoro-phenyl)carbamate as a white powder (10.68 g).", "Method A. Rt: 2.09 min m/z: 262.0 (M−H)− Exact mass: 263.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.48 (s, 9H), 7.37-7.57 (m, 2H), 9.74 (s, 1H).", "HCl (6 M in iPrOH) (20 mL, 120 mmol) was added to tert-butyl N-(3-chloro-4,5-difluoro-phenyl)carbamate (10.68 g, 40.5 mmol) dissolved in dichloromethane (200 mL) and stirred overnight.", "The reaction mixture was concentrated.", "The white solid residue was dissolved in water (100 mL), alkalinized with NaOH 1M and extracted with ether.", "The organic layer was dried over MgSO4, filtered and concentrated yielding 3-chloro-4,5-difluoro-aniline (6.53 g) as a colorless oil which was stored under nitrogen in the dark.", "1H NMR (400 MHz, DMSO-d6) δ ppm 5.53 (s, 2H), 6.34-6.61 (m, 2H).", "3-chloro-4,5-difluoro-aniline (3.43 g, 20.95 mmol) dissolved in toluene (10 mL) was added dropwise during 5 minutes to a solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride (5.07 g, 20.95 mmol) in toluene (525 mL) at reflux.", "The reaction mixture was refluxed 90 minutes and then concentrated in vacuo yielding crude 5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (7.83 g) as a brown powder which was used as such.", "A mixture of 5-[(3-chloro-4,5-difluorophenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (1002 mg, 2.58 mmol) and isopropylamine (457 mg, 7.73 mmol) in acetonitrile (100 mL) was stirred 60 minutes.", "Water was added until crystallisation began.", "The beige crystals were filtered off and dried in vacuo overnight at 50° C., resulting in compound 57 (706 mg).", "Method A, Rt: 1.88 min m/z: 390.0 (M−H)− Exact mass: 391.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.02 (d, J=6.6 Hz, 6H), 3.20-3.30 (m, 1H), 3.92 (s, 3H), 7.22 (d, J=6.8 Hz, 1H), 7.33 (d, J=2.0 Hz, 1H), 7.57 (d, J=1.8 Hz, 1H), 7.75-7.87 (m, 2H), 10.29 (s, 1H).", "Compound 58: 4-(tert-butylsulfamoyl)-N-(3-chloro-4,5-difluoro-phenyl)-1-methyl-pyrrole-2-carboxamide A mixture of 5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (1008 mg, 2.59 mmol), tert-butylamine (569 mg, 7.78 mmol) in acetonitrile (100 mL) was stirred 60 minutes.", "Water was added until crystallisation began.", "The beige crystals were filtered off and dried in vacuo overnight at 50° C., resulting in compound 58 (773 mg) Method A: Rt: 1.95 min m/z: 404.0 (M−H)− Exact mass: 405.1 1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (s, 9H), 3.91 (s, 3H), 7.14 (s, 1H), 7.33 (d, J=1.8 Hz, 1H), 7.55 (d, J=1.8 Hz, 1H), 7.76-7.86 (m, 2H), 10.28 (s, 1H).", "Compound 59: N-(3-chloro-4,5-difluoro-phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)-sulfamoyl]pyrrole-2-carboxamide A mixture of 5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (1.0 g, 2.57 mmol) 3-methyl-3-oxetanamine (560 mg, 6.43 mmol) and acetonitrile (100 mL) was refluxed 30 minutes.", "The reaction mixture was cooled to 20° C. and diluted with water (350 mL).", "The product crystallized, was filtered off and dried in vacuo overnight yielding compound 59 as a beige powder (677 mg).", "Method A, Rt: 1.77 min m/z: 418.0 (M−H)− Exact mass: 419.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (s, 3H), 3.92 (s, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.60 (d, J=6.2 Hz, 2H), 7.34 (d, J=2.0 Hz, 1H), 7.62 (d, J=1.8 Hz, 1H), 7.74-7.87 (m, 2H), 7.98 (s, 1H), 10.30 (s, 1H).", "Compound 60: N-(3-chloro-4,5-difluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide A mixture of 5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (1008 mg, 2.59 mmol), (R)-1,1,1-trifluoro-2-propylamine (1026 mg, 9.07 mmol) in acetonitrile (100 mL) was refluxed overnight.", "Water was added until crystallisation started.", "The beige crystals were filtered of and dried overnight in vacuo at 50° C., resulting in compound 60 (673 mg).", "Method A Rt: 1.92 min m/z: 444.0 (M−H)− Exact mass: 445.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.08 (d, J=7.0 Hz, 3H), 3.83-4.01 (m, 4H), 7.36 (d, J=1.8 Hz, 1H), 7.67 (d, J=1.8 Hz, 1H), 7.75-7.87 (m, 2H), 8.19 (d, J=8.8 Hz, 1H), 10.32 (s, 1H).", "Alternative Synthesis of Compound 60: 1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid (8.0 g, 26.7 mmol), HATU (12.7 g, 33.3 mmol), Et3N (9.3 mL, 66.6 mmol) and 3-chloro-4,5-difluoro-aniline (5.44 g, 33.3 mmol) in DMF (30 mL) was stirred overnight at room temperature.", "The solution was subjected directly to column chromatography on a 330 g Reveleris cartridge in a Biotage system using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated and purified again in the same way.", "The product fractions were concentrated, dissolved in warm EtOAc en the product crystallized upon addition of heptane.", "The white crystals were filtered off and dried over weekend in vacuo at 50° C. The crystals (7.97 g) were dissolved in warm methanol (150 mL) and the product crystallized upon addition of water.", "The product was filtered off and dried in vacuo at 50° C. overnight, resulting in compound 60 (7.44 g).", "[α]36520=−9.5° (c 1.30 w/v %, MeOH).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 204.6° C. Compound 65: N-(3-chloro-4,5-difluoro-phenyl)-4-[(3,3-difluoro-1-methyl-cyclo-butyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide A mixture of 5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (622 mg, 1.69 mmol) 3,3-difluoro-1-methyl-cyclobutanamine hydrochloride (306 mg, 2.527 mmol), DIPEA (0.87 mL, 5.06 mmol) and acetonitrile (100 mL) was refluxed 60 minutes.", "The reaction mixture was concentrated and the obtained residue was dissolved in EtOAc (100 mL), washed with 1M HCl, dried over sodium sulphate, filtered and concentrated.", "The obtained residue was dissolved in acetonitrile (50 mL).", "Water was added until precipitation was observed.", "The mixture was allowed to triturate further overnight.", "The beige crystals were filtered off and dried in vacuo at 50° C., resulting in compound 65 (473 mg).", "Method A; Rt: 1.89 min.", "m/z: 452.0 (M−H)− Exact mass: 453.0.1H NMR (400 MHz, acetonitrile-d3) δ ppm 1.46 (s, 3H), 2.44-2.59 (m, 2H), 2.78-2.94 (m, 2H), 3.92 (s, 3H), 5.89 (s, 1H), 7.14 (d, J=2.0 Hz, 1H), 7.36 (d, J=2.0 Hz, 1H), 7.59 (dt, J=5.8, 2.4 Hz, 1H), 7.65 (ddd, J=12.4, 6.8, 2.6 Hz, 1H), 8.64 (br.", "s., 1H).", "Compound 66: N-(3-chloro-4,5-difluoro-phenyl)-4-(1,1-dimethylpropylsulfamoyl)-1-methyl-pyrrole-2-carboxamide A mixture of 5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (572 mg, 1.472 mmol), tert-amylamine (327 mg, 3.68 mmol) in acetonitrile (75 mL) was stirred 48 hours.", "Water was added until crystallisation began.", "The crystals were filtered off and dried in vacuo at 50° C., resulting in compound 66 (356 mg).", "Method A; Rt: 2.09 min.", "m/z: 418.1 (M−H)− Exact mass: 419.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.78 (t, J=7.4 Hz, 3H), 1.12 (s, 6H), 1.49 (q, J=1.0 Hz, 2H), 3.91 (s, 3H), 7.01 (s, 1H), 7.33 (d, J=2.0 Hz, 1H), 7.54 (d, J=1.8 Hz, 1H), 7.75-7.87 (m, 2H), 10.28 (s, 1H).", "Compound 72: N-(3-chloro-4,5-difluoro-phenyl)-1-methyl-4-[[1-(trifluoromethyl)-cyclopropyl]sulfamoyl]pyrrole-2-carboxamide A mixture of 5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (1274 mg, 3.28 mmol), 1-(trifluoromethyl)cyclopropanamine (1000 mg, 7.99 mmol) and triethylamine (0.57 mL, 4.1 mmol) in acetonitrile (100 mL) was refluxed overnight.", "An equal amount of 1-(trifluoromethyl)cyclopropanamine was added and the reaction mixture was further refluxed overnight.", "The reaction mixture was concentrated.", "The residue was dissolved in EtOAc (100 mL), washed with 1M HCl, dried over sodium sulphate, filtered and concentrated.", "The residue was purified by column chromatography on silica using a gradient from 10 to 100% EtOAc in heptane.", "The pure fractions were concentrated yielding compound 72 (42.4 mg) as a powder.", "Method A; Rt: 1.95 min.", "m/z: 456.0 (M−H)− Exact mass: 457.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.10-1.22 (m, 4H), 3.91 (s, 3H), 7.31 (d, J=1.8 Hz, 1H), 7.59 (d, J=1.8 Hz, 1H), 7.74-7.86 (m, 2H), 8.74 (s, 1H), 10.30 (s, 1H).", "Compound 73: N-(3-chloro-4,5-difluoro-phenyl)-1-methyl-4-[[2,2,2-trifluoro-1-(methoxymethyl)-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide A mixture of 5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (318 mg, 0.817 mmol), 1,1,1-trifluoro-3-methoxy-2-methyl-propan-2-amine hydrochloride (237 mg, 1.23 mmol) and triethylamine (0.34 mL, 1.45 mmol) in acetonitrile (7 mL) was heated in a microwave oven at 150° C. during 30 minutes.", "The reaction mixture was concentrated.", "The residue was dissolved in water (50 mL) and washed with 1M HCl.", "The organic layer was dried over sodium sulphate, filtered and concentrated.", "The residue was subjected to column chromatography on silica using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated and the residue was crystallized by dissolving in methanol (5 mL) upon addition of water.", "The crystals were filtered off and dried overnight in vacuo at 50° C., resulting in compound 73 (17.8 mg).", "Method A; Rt: 1.97 min.", "m/z: 488.0 (M−H)− Exact mass: 489.0.1H NMR (360 MHz, DMSO-d6) δ ppm 1.41 (s, 3H), 3.23 (s, 3H), 3.46 (s, 2H), 3.92 (s, 3H), 7.34 (d, J=1.8 Hz, 1H), 7.60 (d, J=1.8 Hz, 1H), 7.74-7.89 (m, 2H), 8.04 (s, 1H), 10.34 (s, 1H).", "Compound 96: N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide 2,2,2-trifluoro-1,1-dimethyl-ethylamine (0.344 g, 2.71 mmol) was dissolved in pyridine (10 mL, dried on molecular sieves) under N2-atm.", "5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (0.5 g, 1.35 mmol) was added.", "The reaction mixture was stirred at room temperature for 20 hours.", "The reaction mixture was treated with HCl 1M (100 mL) and extracted with EtOAc.", "The combined organic layer was washed with water followed by saturated NaHCO3, dried with Na2SO4 and the solvent was evaporated.", "The residue was dissolved in CH2Cl2 (5 mL) and the formed precipitate was filtered off and washed with CH2Cl2 (2×5 mL).", "The filtrate was concentrated and the obtained residue was purified by silica gel chromatography (EtOAc-heptane 0/100 to 100/0) and further purified by reverse phase column chromatography, resulting in compound 96 (45 mg) as a white solid.", "Method A; Rt: 2.03 min.", "m/z: 457.9 (M−H)− Exact mass: 459.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.35 (s, 6H), 3.92 (s, 3H), 7.34 (d, J=2.0 Hz, 1H), 7.59 (s, 1H), 7.75-7.89 (m, 2H), 8.08 (br.", "s., 1H), 10.33 (br.", "s., 1H).", "Compound 61: 2-[[5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrol-3-yl]-sulfonylamino]-2-methyl-propanoic acid LiOH (0.567 g, 13.5 mmol) was dissolved in water (20 mL) and added dropwise to a mixture of compound 49 (1.39 g, 3.38 mmol) in MeOH (40 mL).", "The reaction mixture was stirred at 50° C. for 7 hour.", "Then HCl 1N (15 mL, 15.2 mmol) was added dropwise After 16 hour without stirring the white precipitate was filtered off, washed with Methanol/Water (2:1; 2×60 mL).", "The white solid was dried in vacuo at 50° C. resulting in compound 61 (1.09 g).", "Method A; Rt: 1.19 min.", "miz: 396.0 (M−H)− Exact mass: 397.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.32 (s, 6H), 2.22 (d, J=1.5 Hz, 3H), 3.89 (s, 3H), 7.05-7.13 (m, 1H), 7.30 (d, J=1.8 Hz, 1H), 7.45-7.55 (m, 2H), 7.57-7.68 (m, 2H), 10.01 (s, 1H), 12.42-12.58 (m, 1H).", "Compound 62: 4-[[1,1-dimethyl-2-(methylamino)-2-oxo-ethyl]sulfamoyl]-N-(4-fluoro-3-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide 1,1′-carbonyldiimidazole (CDI, 0.326 g, 2.013 mmol) was added to a stirring solution of compound 61 (0.32 g, 0.805 mmol) in acetonitrile dried on molecular sieves (10 mL).", "The reaction mixture was stirred in a sealed tube at room temperature for 2 hour.", "Next, methylamine (2M in Methanol, 4.0 mL, 8.1 mmol) was added.", "The reaction mixture was stirred for 2.5 hour at room temperature.", "The solvent and the excess of methylamine were removed and the mixture was purified by silica gel column chromatography (EtOAc/Heptane 0/100 to 100/0).", "The desired fractions were combined and the solvent was evaporated and dried in vacuo resulting in compound 62 (221 mg) as a white solid.", "Method A; Rt: 1.49 min.", "m/z: 409.0 (M−H)− Exact mass: 410.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.30 (s, 6H), 2.23 (d, J=1.5 Hz, 3H), 2.53 (d, J=4.6 Hz, 3H), 3.89 (s, 3H), 7.06-7.13 (m, 1H), 7.27-7.30 (m, 1H), 7.32-7.36 (m, 1H), 7.43-7.48 (m, 1H), 7.50-7.54 (m, 2H), 7.61-7.66 (m, 1H), 9.97-10.04 (m, 1H).", "Compound 63: 4-[[2-(dimethylamino)-1,1-dimethyl-2-oxo-ethyl]sulfamoyl]-N-(4-fluoro-3-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide 1,1′-carbonyldiimidazole (CDI, 0.149 g, 0.921 mmol) was added to a stirring mixture of compound 61 (0.366 g, 0.921 mmol) in acetonitrile in a sealed tube under N2 atmosphere.", "The resultant solution was stirred at room temperature for 18 hours.", "Then, more (CDI, 0.224 g, 1.381 mmol) was added and the mixture was further stirred for 2 hours.", "An excess of dimethylamine was added (10 drops out of a pressure bottle).", "The reaction mixture was stirred at room temperature for 5 h. The precipitate was filtered off, washed with AcCN (1×2 mL) and the solid was dried at 50° C. in vacuo yielding compound 63 (323 mg) as a a white powder.", "Method A; Rt: 1.51 min.", "m/z: 423.2 (M−H)− Exact mass: 424.2.1H NMR (400 MHz, DMSO-d6, 100° C.) δ ppm 1.39 (s, 6H), 2.22 (d, J=1.8 Hz, 3H), 2.97 (s, 6H), 3.91 (s, 3H), 7.02 (t, J=9.2 Hz, 1H), 7.25 (d, J=1.8 Hz, 2H), 7.37 (d, J=1.8 Hz, 1H), 7.45-7.52 (m, 1H), 7.58 (dd, J=7.0, 2.4 Hz, 1H), 9.74 (br.", "s., 1H).", "Compound 64: 4-[(2-amino-1,1-dimethyl-2-oxo-ethyl)sulfamoyl]-N-(4-fluoro-3-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide 1,1′-carbonyldiimidazole (CDI, 0.295 g, 1.820 mmol) was added to a stirring mixture of compound 61 (0.289 g, 0.727 mmol) in acetonitrile in a sealed tube under N2 atmosphere and stirred 3 hours.", "The reaction mixture was added dropwise to 7M NH3 in methanol (25 mL).", "The solvent was evaporated leaving a yellow oil which was purified by silica gel column chromatography (EtOAc/Heptane 0/100 to 100/0).", "The desired fractions were combined and the solvent was evaporated and dried in vacuo resulting in compound 64 (123 mg) as a solid.", "Method A; Rt: 1.44 min.", "m/z: 395.0 (M−H)− Exact mass: 396.1.1H NMR (400 MHz, DMSO-d6, 60° C.) δ ppm 1.35 (s, 6H), 2.22 (d, J=1.8 Hz, 3H), 3.90 (s, 3H), 6.91 (br.", "s., 2H), 7.02-7.08 (m, 1H), 7.11 (br.", "s., 1H), 7.30 (d, J=2.0 Hz, 1H), 7.47-7.54 (m, 2H), 7.61 (dd, J=7.4, 2.3 Hz, 1H), 9.86 (br.", "s., 1H).", "Compound 67: 4-(tert-butylsulfamoyl)-N-(2,6-dideuterio-4-fluoro-3-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide t-Butylamine (245 mg, 3.35 mmol) was added to a solution of 5-[(2,6-dideuterio-4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (372 mg, 1.116 mmol) in acetonitrile (25 mL) and stirred overnight.", "Water was added until crystallization began.", "The precipitate was filtered off and dried in vacuo at 50° C., resulting in compound 67 (260 mg) Method A; Rt: 1.76 min.", "m/z: 368.1 (M−H)− Exact mass: 369.2.1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (s, 9H), 2.22 (d, J=2.0 Hz, 3H), 3.90 (s, 3H), 7.06-7.11 (m, 2H), 7.29 (d, J=2.0 Hz, 1H), 7.49 (d, J=1.5 Hz, 1H), 10.00 (s, 1H).", "Compound 68: 4-(tert-butylsulfamoyl)-1-methyl-N-(3,4,5-trifluorophenyl)pyrrole-2-carboxamide t-Butylamine (498 mg, 6.806 mmol) was added to a solution of 1-methyl-5-[(3,4,5-trifluorophenyl)carbamoyl]pyrrole-3-sulfonyl chloride (800 mg, 2.269 mmol) in acetonitrile (50 mL) and stirred 3 hours.", "Water was added until crystallization began.", "The precipitate was filtered off and dried in vacuo at 50° C. Method A; Rt: 1.91 min.", "m/z: 388.1 (M−H)− Exact mass: 389.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (s, 9H), 3.91 (s, 3H), 7.14 (s, 1H), 7.32 (d, J=2.0 Hz, 1H), 7.55 (d, J=1.5 Hz, 1H), 7.67 (dd, J=10.6, 6.6 Hz, 2H), 10.30 (s, 1H).", "Compound 69: N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[2,2,2-trideuterio-1,1-bis(trideuteriomethyl)ethyl]sulfamoyl]pyrrole-2-carboxamide 1,1,1,3,3,3-hexadeuterio-2-(trideuteriomethyl)propan-2-amine (473 mg, 5.76 mmol) was added to a solution of 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (635 mg, 1.92 mmol) in acetonitrile (43 mL) and stirred overnight.", "Water was added until crystallization began.", "The precipitate was filtered off and dried in vacuo at 50° C. Method A; Rt: 1.74 min.", "m/z: 375.1 (M−H)− Exact mass: 376.2.1H NMR (400 MHz, DMSO-d6) δ ppm 2.23 (d, J=1.5 Hz, 3H), 3.90 (s, 3H), 7.04-7.13 (m, 2H), 7.29 (d, J=1.8 Hz, 1H), 7.47-7.56 (m, 2H), 7.64 (dd, J=7.2, 2.5 Hz, 1H), 10.00 (s, 1H).", "Compound 70: N-(2,6-dideuterio-4-fluoro-3-methyl-phenyl)-1-methyl-4-[[2,2,2-trideuterio-1,1-bis(trideuteriomethyl)ethyl]sulfamoyl]pyrrole-2-carboxamide 1,1,1,3,3,3-hexadeuterio-2-(trideuteriomethyl)propan-2-amine (377 mg, 4.59 mmol) was added to a solution of 5-[(2,6-dideuterio-4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (611 mg, 1.84 mmol) in acetonitrile (41 mL) and stirred overnight.", "Water was added until crystallization began.", "The precipitate was filtered off and dried in vacuo at 50° C. Method A; Rt: 1.82 min.", "m/z: 377.1 (M−H)− Exact mass: 378.2.1H NMR (400 MHz, DMSO-d6) δ ppm 2.23 (d, J=2.0 Hz, 3H), 3.90 (s, 3H), 7.05-7.12 (m, 2H), 7.29 (d, J=2.0 Hz, 1H), 7.49 (d, J=1.8 Hz, 1H), 10.00 (s, 1H).", "Compound 71: 4-(tert-butylsulfamoyl)-N-(2,6-dideuterio-3,4,5-trifluoro-phenyl)-1-methyl-pyrrole-2-carboxamide t-Butylamine (331 mg, 4.53 mmol) was added to a solution of 5-[(2,6-dideuterio-3,4,5-trifluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (666 mg, 1.51 mmol) (obtained similarly as described in the synthesis for compound 56, starting from 3,4,5-trifluoroaniline instead of 4-fluoro-3-methyl-aniline, via 2,6-dideuterio-3,4,5-trifluoro-aniline) in acetonitrile (30 mL) and stirred 1 hour.", "Water was added until crystallization began.", "The precipitate was filtered off and dried overnight in vacuo at 50° C. Method A; Rt: 1.89 min.", "m/z: 389.9 (M−H)− Exact mass: 391.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (s, 9H), 3.91 (s, 3H), 7.14 (s, 1H), 7.32 (d, J=2.0 Hz, 1H), 7.55 (d, J=1.5 Hz, 1H), 10.30 (s, 1H).", "Synthesis of 3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylic acid Sodium hydride (914 mg, 23.87 mmol) was added to a solution of ethyl 3-fluoro-1H-pyrrole-2-carboxylate (2885 mg, 18.36 mmol) and iodomethane (3888 mg, 23.9 mmol) in dry DMF (43 mL) and the mixture was stirred for 17 hours.", "The reaction mixture was acidified with 1M HCl and concentrated.", "The residue was dissolved in water/EtOAc.", "The organic layer was dried over sodium sulphate, filtered and concentrated.", "The obtained residue was dissolved in acetonitrile (50 mL), washed with heptane and concentrated yielding a brown liquid of crude ethyl 3-fluoro-1-methyl-pyrrole-2-carboxylate, which was used as such.", "Chlorosulfonic acid (1344 mg, 11.53 mmol) was dissolved in dichloromethane (50 mL) and cooled in an icebath.", "Crude ethyl 3-fluoro-1-methyl-pyrrole-2-carboxylate (1880 mg) was added and the reaction mixture was stirred 90 minutes.", "The reaction mixture was concentrated and the brown residual powder was dried for 17 hours in vacuo at 50° C. (5-ethoxycarbonyl-4-fluoro-1-methyl-pyrrole-3-sulfonic acid, 2477 mg) Method A; Rt: 0.76 min.", "m/z: 250.0 (M−H)− Exact mass: 251.0.A mixture of crude 5-ethoxycarbonyl-4-fluoro-1-methyl-pyrrole-3-sulfonic acid (2318 mg) in thionylchloride (20 mL) was heated at 80° C. during 30 minutes.", "The solution was concentrated and the residue (containing ethyl 4-chlorosulfonyl-3-fluoro-1-methyl-pyrrole-2-carboxylate) dissolved in acetonitrile (25 mL).", "3-methyloxetan-3-amine (3035 mg, 34.84 mmol) dissolved in acetonitrile (20 mL) was added and the reaction mixture was stirred 1 hour at room temperature.", "The reaction mixture was concentrated.", "The obtained residue was dissolved in dichloromethane (200 mL), washed with water, dried over sodium sulphate, filtered and concentrated.", "The residue was purified by column chromatography on silica using a gradient from 5 to 100% EtOAc in heptane.", "The product fractions were concentrated in vacuo yielding ethyl 3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylate (1900 mg) as a white powder.", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.28 (t, J=7.2 Hz, 3H), 1.52 (s, 3H), 3.83 (s, 3H), 4.15 (d, J=6.4 Hz, 2H), 4.27 (q, J=7.0 Hz, 2H), 4.61 (d, J=5.9 Hz, 2H), 7.57 (d, J=4.6 Hz, 1H), 8.28 (s, 1H).", "A mixture of ethyl 3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylate (1900 mg, 5.93 mmol), lithium hydroxide (426 mg, 17.8 mmol), THF (20 mL) and distilled water (5 mL) was stirred 210 minutes at room temperature.", "THF was distilled off and the mixture neutralized with 1M HCl (5.9 mL, 5.9 mmol).", "The mixture was extracted with 2-methyltetrahydrofuran (3×100 mL).", "The combined organic layers were dried over sodium sulphate, filtered and concentrated.", "The resulting white powder was dried overnight in vacuo at 50° C. (3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylic acid, 1710 mg) Method A; Rt: 0.68 min.", "m/z: 290.9 (M−H)− Exact mass: 292.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.52 (s, 3H), 3.82 (s, 3H), 4.15 (d, J=6.6 Hz, 2H), 4.61 (d, J=5.9 Hz, 2H), 7.52 (d, J=4.6 Hz, 1H), 8.26 (s, 1H), 13.11 (br.", "s, 1H).", "Compound 74: N-(3,4-difluorophenyl)-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)-sulfamoyl]pyrrole-2-carboxamide Triethylamine (0.19 mL, 1.36 mmol) was added to a solution of 3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylic acid (133 mg, 0.57 mmol) in DMF (1 mL) followed by HATU (216 mg, 0.57 mmol) and stirred 20 minutes.", "Then 3,4-difluoroaniline (117 mg, 0.91 mmol) was added and the reaction mixture stirred overnight.", "The mixture was concentrated in vacuo.", "The residue was mixed with water (10 mL) and extracted with EtOAc (2×30 mL).", "The organic layer was dried over sodium sulphate, filtered and concentrated.", "The obtained residue was purified by column chromatography on silica using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated and the remaining white powder was dissolved in warm EtOAc (10 mL) and upon addition of heptane the compound crystallized.", "The white crystals were filtered off and dried in vacuo, resulting in compound 74 (102 mg) Method A; Rt: 1.62 min.", "m/z: 401.9 (M−H)− Exact mass: 403.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.56 (s, 3H), 3.80 (s, 3H), 4.17 (d, J=6.4 Hz, 2H), 4.64 (d, J=6.2 Hz, 2H), 7.35-7.47 (m, 2H), 7.51 (d, J=4.6 Hz, 1H), 7.75-7.87 (m, 1H), 8.30 (s, 1H), 10.24 (s, 1H).", "Compound 75: N-(3,5-Dichloro-4-fluorophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide 3,5-dichloro-4-fluoroaniline (1534 mg, 8.5 mmol) dissolved in toluene (10 mL) was added to 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride (2063 mg, 8.52 mmol) in toluene (115 mL) at reflux and refluxed 2 hours.", "The reaction mixture was filtered while still hot and the filtrate was concentrated, yielding crude 5-[(3,5-dichloro-4-fluorophenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride as a crude beige powder which was used as such.", "1H NMR (400 MHz, acetonitrile-d3) δ ppm 3.96 (s, 3H), 7.39 (d, J=2.0 Hz, 1H), 7.71-7.77 (m, 3H), 8.78 (br.", "s., 1H).", "3-methyl-3-oxetanamine (407.3 mg, 4.68 mmol) was added to crude 5-[(3,5-dichloro-4-fluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (601 mg) in acetonitrile (57 mL) and stirred overnight.", "Water was added until crystallisation began.", "The formed white crystals were filtered off and dried in vacuo at 50° C. during 4 hours.", "Compound 75 was recrystallized from EtOAc upon addition of heptane.", "The white crystals (346 mg) were filtered off and dried in vacuo at 50° C. over weekend.", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (s, 3H), 3.92 (s, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.35 (d, J=2.0 Hz, 1H), 7.62 (d, J=1.8 Hz, 1H), 7.95 (d, J=6.2 Hz, 2H), 7.99 (s, 1H), 10.27 (s, 1H).", "Method A; Rt: 1.77 min.", "m/z: 434.0 (M−H)− Exact mass: 435.0.Compound 76: 4-(tert-Butylsulfamoyl)-N-(3,5-dichloro-4-fluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide tert-butylamine (450.6 mg, 6.16 mmol) was added to crude 5-[(3,5-dichloro-4-fluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (792 mg) in acetonitrile (75 mL) and stirred 2 hours.", "Water was added until crystallisation began.", "The white crystals were filtered off and dried overnight in vacuo at 50° C., resulting in compound 76 (517 mg).", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (s, 9H), 3.91 (s, 3H), 7.14 (s, 1H), 7.33 (d, J=1.8 Hz, 1H), 7.55 (d, J=1.5 Hz, 1H), 7.95 (d, J=6.2 Hz, 2H), 10.26 (s, 1H).", "Method A; Rt: 1.99 min.", "m/z: 420.0 (M−H)− Exact mass: 421.0.Compound 77: N-(4-Chloro-3-methylphenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide DIPEA (0.471 mL, 2.73 mol) was added to a stirring mixture of 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylic acid (0.25 g, 0.000911 mol) and CH3CN (5 mL) under N2-atmosphere.", "To the resulting solution was added 4-chloro-3-methylaniline (0.142 g, 1 mmol), then HATU (364 mg, 0.957 mmol).", "The reaction mixture was stirred at room temperature for 3 hours and left standing for 2 hours.", "The product was filtered off, washed with CH3CN (5×), and dried at 50° C. in vacuo, resulting in compound 77 (190 mg).", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.55 (s, 3H), 2.32 (s, 3H), 3.92 (s, 3H), 4.13 (d, J=6.2 Hz, 2H), 4.60 (d, J=6.2 Hz, 2H), 7.31-7.40 (m, 2H), 7.54-6 7.62 (m, 2H), 7.73 (d, J=2.2 Hz, 1H), 7.95 (s, 1H), 10.08 (s, 1H).", "Method A; Rt: 1.70 min.", "m/z: 396.0 (M−H)− Exact mass: 397.1.Compound 78: N-(3-Chloro-4-fluorophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylic acid (250 mg, 0.911 mmol) and HATU (433 mg, 1.14 mmol) were dissolved in DMF (5 mL) and stirred for 10 minutes.", "3-chloro-4-fluoroaniline (265 mg, 1.8 mmol) and DIPEA (0.471 mL, 2.73 mmol) were added and the reaction mixture was stirred overnight at room temperature.", "The volatiles were removed under reduced pressure and the residue was purified on silica using a heptane to EtOac gradient yielding compound 78 as a white powder after trituration in MeOH.", "Method B; Rt: 0.93 min.", "m/z: 400.0 (M−H)− Exact mass: 401.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (s, 3H), 3.92 (s, 3H), 4.13 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.34 (d, J=2.0 Hz, 1H), 7.40 (t, J=9.1 Hz, 1H), 7.60 (d, J=1.8 Hz, 1H), 7.66 (ddd, J=9.1, 4.3, 2.6 Hz, 1H), 7.96 (br.", "s., 1H), 8.01 (dd, J=6.9, 2.5 Hz, 1H), 10.21 (s, 1H).", "Compound 79: N-[4-Fluoro-3-methyl-5-(trifluoromethyl)phenyl]-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 79 (1.9 g) was prepared similarly as described for compound 75, using 4-fluoro-3-methyl-5-(trifluoromethyl)aniline instead of 3,5-dichloro-4-fluoroaniline 1H NMR (400 MHz, DMSO-d6) δ ppm 1.55 (s, 3H), 2.31 (d, J=2.0 Hz, 3H), 3.92 (s, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.36 (d, J=2.0 Hz, 1H), 7.60 (d, J=1.8 Hz, 1H), 7.92-8.03 (m, 3H), 10.25 (br.", "s, 1H).", "Method B; Rt: 1.04 min.", "m/z: 448.1 (M−H)− Exact mass: 449.1.Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 192.0° C. Compound 80: N-(4-Fluoro-3,5-dimethylphenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylic acid (200 mg, 0.73 mmol) was dissolved in N,N-dimethylformamide (2 mL).", "HATU (0.35 g, 0.91 mmol) was added followed by diisopropylethylamine (0.38 mL, 2.19 mmol).", "The resulting mixture was stirred for 30 minutes at room temperature.", "Then, 4-fluoro-3,5-dimethylaniline (0.2 g, 1.46 mmol) was added.", "The resulting mixture was stirred for 24 hours and next poured onto 10 mL of ice.", "The mixture was extracted using 2-Me-THF (3×10 mL).", "The combined organics were washed with brine, dried on Na2SO4, filtered and concentrated in vacuo.", "The obtained residue was purified by silica gel column chromatography using gradient elution from heptane to EtOAc.", "(100:0 to 0:100).", "The desired fractions were concentrated in vacuo and dried in a vacuum oven at 55° C. for 24 hours yielding compound 80 (130 mg): Method B; Rt: 0.93 min.", "m/z: 394.2 (M−H)− Exact mass: 395.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.55 (s, 3H), 2.21 (d, J=1.8 Hz, 6H), 3.91 (s, 3H), 4.13 (d, J=5.7 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.31 (d, J=1.8 Hz, 1H), 7.43 (d, J=6.6 Hz, 2H), 7.56 (d, J=1.8 Hz, 1H), 7.94 (br.", "s., 1H), 9.94 (br.", "s, 1H).", "Compound 81: N-(3-Bromo-4-fluorophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 81 (129 mg) was prepared as described for compound 80 using 3-bromo-4-fluoroaniline instead of 4-fluoro-3,5-dimethylaniline.", "Method B; Rt: 0.93 min.", "m/z: 444.1 (M−H)− Exact mass: 445.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.47-1.60 (m, 3H), 3.83-3.99 (m, 3H), 4.13 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.28-7.44 (m, 2H), 7.59 (d, J=1.8 Hz, 1H), 7.71 (ddd, J=9.0, 4.4, 2.4 Hz, 1H), 7.97 (br.", "s., 1H), 8.13 (dd, J=6.5, 2.5 Hz, 1H), 10.20 (br.", "s., 1H).", "Compound 82: 1-Methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-N-[3-methyl-5-(trifluoro-methyl)phenyl]-1H-pyrrole-2-carboxamide Compound 82 (167 mg) was prepared as described for compound 80 using 3-methyl-5-trifluoromethylaniline instead of 4-fluoro-3,5-dimethylaniline.", "Method B; Rt: 1.01 min.", "m/z: 430.2 (M−H)− Exact mass: 431.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.55 (s, 3H), 2.39 (s, 3H), 3.92 (s, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.26 (s, 1H), 7.39 (d, J=2.0 Hz, 1H), 7.60 (d, J=1.8 Hz, 1H), 7.84 (s, 1H), 7.90-8.08 (m, 2H), 10.24 (br.", "s., 1H).", "Compound 83: N-(4-Cyano-3-methylphenyl)-1-methyl-4-[(3-methyloxetan-3-ylsulfamoyl]-1H-pyrrole-2-carboxamide Compound 83 (76 mg) was prepared as described for compound 80 using 4-amino-2-methyl-benzonitrile instead of 4-fluoro-3,5-dimethylaniline.", "Method B; Rt: 0.81 min.", "m/z: 387.1 (M−H)− Exact mass: 388.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.48-1.59 (m, 3H), 2.46 (s, 3H), 3.87-3.98 (m, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.40 (d, J=2.0 6 Hz, 1H), 7.62 (d, J=1.8 Hz, 1H), 7.69-7.77 (m, 2H), 7.86 (s, 1H), 7.98 (br.", "s., 1H), 10.32 (br.", "s., 1H).", "Compound 84: N-(4-Chloro-3-fluorophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylic acid (200 mg, 0.729 mmol) was dissolved in DMF (5 mL) and triethylamine (0.405 mL, 2.92 mmol) and HATU (360 mg, 0.95 mmol) were added.", "After 10 minutes, 4-chloro-3-fluoroaniline (212 mg, 1.46 mmol) was added.", "The reaction mixture was stirred at room temperature for 1 hour and heated at 50° C. for 1 hour.", "More 4-chloro-3-fluoroaniline (424 mg, 2.92 mmol) was added to the reaction mixture.", "The reaction mixture was stirred at 60° C. for 1 hour.", "The mixture was poured into water (50 mL) and filtered.", "The formed precipitate was filtered and the solid was washed with water.", "The filtrate was stored for 42 hours and the formed precipitate was filtered and washed with water.", "The solids were combined, and further purified using silica gel column chromatography (ethyl acetate in heptane from 0 to 100%) resulting in compound 84 as a white solid.", "The white solid was triturated in methanol (5 mL), filtered and dried in vacuum oven overnight resulting in compound 84 (119 mg) as a white powder.", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (s, 3H), 3.92 (s, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.36 (d, J=1.8 Hz, 1H), 7.45-7.67 (m, 3H), 7.68-8.56 (m, 2H), 10.30 (br.", "s., 1H).", "Method B; Rt: 0.96 min.", "m/z: 400.1 (M−H)− Exact mass: 401.1.Compound 85: N-(2,4-Difluoro-3-methylphenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide 2,4-difluoro-3-methyl-aniline (0.306 g, 2.14 mol) was dissolved in acetonitrile (50 mL, 0.957 mol), 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylic acid (0.645 g, 2.35 mmol) and Et3N (0.891 mL, 6.41 mmol) were added.", "HATU (0.975 g, 2.57 mmol) was added at once.", "The reaction mixture was stirred at room temperature for 1 hour.", "Then the reaction mixture was stirred at 40° C. for 80 hours.", "The solvent was removed, water (1×50 mL) was added and the mixture was washed with brine (1×5 mL) and extracted with EtOAc (2×50 mL).", "The combined organic layers were dried with Na2SO4 and the solvent was removed by evaporation.", "The crude mixture was purified by silica gel chromatography (EtOAc-heptane 0/100 to 100/0).", "The desired fractions were combined and evaporated.", "The obtained solid was crystallized by evaporation of a acetonitrile/H2O solution, the precipitate was filtered off, washed with water (2 mL) and dried at 50° C. in vacuo, resulting in compound 85.Method A; Rt: 1.55 min.", "m/z: 398.1 (M−H)− Exact mass: 399.1.1H NMR (360 MHz, DMSO-d6) δ ppm 1.55 (s, 3H), 2.18 (s, 3H), 3.89 (s, 3H), 4.13 (s, 2H), 4.59 (s, 2H), 7.07 (td, J=9.0, 1.8 Hz, 1H), 7.28-7.39 (m, 2H), 7.59 (d, J=1.8 Hz, 1H), 8.00 (br.", "s., 1H), 9.95 (br.", "s., 1H).", "Compound 86: N-[4-Fluoro-3-(trifluoromethoxy)phenyl]-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 86 (127 mg) was prepared similar as described for compound 80 using 4-fluoro-3-(trifluoromethoxy)aniline instead of 4-fluoro-3,5-dimethylaniline.", "Method B, Rt: 1.01 min.", "m/z: 450.2 (M−H)− Exact mass: 451.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (s, 3H), 3.92 (s, 3H), 4.14 (d, J=6.2 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.35 (d, J=2.0 Hz, 1H), 7.45-7.53 (m, 1H), 7.60 (d, J=1.8 Hz, 1H), 7.68-7.77 (m, 1H), 7.97 (s, 1H), 7.99-8.07 (m, 1H), 10.29 (br.", "s, 1H).", "Compound 87: N-(3-Chloro-5-cyanophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 87 was prepared similar as described for compound 75 using 3-amino-5-chlorobenzonitrile instead of 3,5-dichloro-4-fluoroaniline.", "The reaction mixture was filtered and the solids were washed with water.", "The grey powder was dissolved in ethyl acetate (300 mL) and washed with aqueous HCl (1 N, 50 mL), saturated aqueous sodium bicarbonate (30 mL) and brine, dried (Na2SO4), and evaporated to dryness and dried overnight in vacuum oven at 50° C., resulting in compound 87 (867 mg) as a white powder.", "Method B; Rt: 0.91 min.", "m/z: 407.1 (M−H)− Exact mass: 408.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (s, 3H), 3.93 (s, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.38 (d, J=1.8 Hz, 1H), 7.64 (d, J=1.5 Hz, 1H), 7.74 (dd, J=2.0, 1.3 Hz, 1H), 8.00 (s, 1H), 8.10-8.13 (m, 1H), 8.15 (t, J=2.0 Hz, 1H), 10.42 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 209.4° C. Compound 88: N-(4-Fluoro-3-methylphenyl)-1,3,5-trimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Ethyl 1,3,5-trimethylpyrrole-2-carboxylate (1000 mg, 5.52 mmol) was added in 5 portions to chlorosulfonic acid (5 mL) at 0° C. under nitrogen atmosphere.", "The reaction mixture was warmed to room temperature and allowed to stir overnight.", "The reaction mixture was slowly added to ice cold water (50 mL), followed by extraction with CH2Cl2 (3×50 mL).", "The combined organic extracts were dried (Na2SO4) and concentrated resulting in crude ethyl 4-chlorosulfonyl-1,3,5-trimethyl-pyrrole-2-carboxylate (510 mg) as brown oil which solidified on standing.", "Crude ethyl 4-chlorosulfonyl-1,3,5-trimethyl-pyrrole-2-carboxylate (500 mg) was dissolved in acetonitrile (50 mL) and 3-methyl-3-oxetanamine (622.9 mg, 7.15 mmol) was added.", "The reaction mixture was stirred at room temperature for 2 hours.", "Water (100 mL) was added and the mixture was extracted with CH2Cl2 (3×50 mL) and the combined organic layers were washed with brine, dried and evaporated to afford a brown sticky oil.", "The oil was purified using silica gel column chromatography (ethyl acetate in heptane from 0 to 100%) resulting in ethyl 1,3,5-trimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylate (100 mg) as a white solid.", "Method B; Rt: 0.83 min.", "m/z: 329.1 (M−H)− Exact mass: 330.1.Ethyl 1,3,5-trimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylate was dissolved in ethanol (10 mL) and NaOH (1M in H2O, 0.61 mL) was added.", "The resulting solution was stirred at room temperature for 42 hours.", "The reaction mixture was stirred at 70° C. for 20 hours.", "NaOH (1 M in H2O, 0.61 mL) was added to the reaction mixture which was stirred at 80° C. for 64 hours.", "The reaction mixture was allowed to reach room temperature.", "Triethylamine hydrochloride (222 mg, 1.61 mmol) was added, the reaction mixture was evaporated to dryness and co evaporated with toluene (2×20 mL) to afford a residue which was used as such.", "The obtained residue was dissolved in DMF (5 mL).", "Triethylamine (0.23 mL, 1.654 mmol) and HATU (150.9 mg, 0.397 mmol) were added and the reaction mixture was stirred at room temperature for 10 minutes.", "4-fluoro-3-methylaniline (124 mg, 0.99 mmol) was added to the reaction mixture which was stirred at room temperature for 42 hours.", "The reaction mixture was poured into water.", "The dark brown precipitate was filtered and washed with water.", "The filtrate was extracted with Me-THF (2×20 mL) and EtOAc (2×30 mL).", "The combined organic layers were washed with brine, combined with the dark brown precipitate, dried (Na2SO4) and evaporated.", "The obtained residue was purified using silica gel column chromatography (ethyl acetate in heptane from 0 to 100% and methanol in CH2Cl2 from 0 to 2%) to afford compound 88 (17.2 mg) as a powder.", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.49 (s, 3H), 2.23 (d, J=1.8 Hz, 3H), 2.28 (s, 3H), 2.43 (s, 3H), 3.56 (s, 3H), 4.12 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.10 (t, J=9.2 Hz, 1H), 7.46-7.54 (m, 1H), 7.61 (dd, J=7.0, 2.2 Hz, 1H), 7.78 (br.", "s, 1H), 10.09 (s, 1H).", "Method B; Rt: 0.90 min.", "m/z: 408.2 (M−H)− Exact mass: 409.1.Compound 89: N-(4-Fluoro-3-methylphenyl)-1,5-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Ethyl 1,5-dimethyl-1H-pyrrole-2-carboxylate (2.5 g, 14.95 mmol) was added drop wise to chlorosulfonic acid (10 mL) at 0° C. under nitrogen atmosphere.", "The reaction mixture was warmed to room temperature and allowed to stir overnight.", "The reaction mixture was slowly added to ice cold water, followed by extraction with CH2Cl2.The combined organic extracts were dried (Na2SO4) and concentrated resulting in crude ethyl 4-chlorosulfonyl-1,5-dimethyl-pyrrole-2-carboxylate (2.9 g) as light purple powder.", "1H NMR (400 MHz, acetonitrile-d3) δ ppm 1.32 (t, J=7.0 Hz, 3H), 2.54 (s, 3H), 3.86 (s, 3H), 4.28 (q, J=7.2 Hz, 2H), 7.30 (s, 1H).", "Crude ethyl 4-chlorosulfonyl-1,5-dimethyl-pyrrole-2-carboxylate (1500 mg, 5.65 mmol was dissolved in acetonitrile (15 mL).", "Hunig's base (2.4 mL, 14.1 mmol) and 3-methyl-3-oxetanamine (639 mg, 7.33 mmol) were added to the reaction mixture.", "The reaction mixture was stirred at room temperature for 42 hours.", "Water was added and the mixture was extracted with CH2Cl2 (2×50 mL) and EtOAc (2×50 mL).", "The combined organic layers were dried (Na2SO4) and evaporated to dryness.", "The obtained crude ethyl 1,5-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylate (1.8 g) was used as such.", "Method B; Rt: 0.77 min.", "m/z: 315.1 (M−H)− Exact mass: 316.1.Crude ethyl 1,5-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylate (1800 mg, 5.689 mmol) was dissolved in methanol (8 mL), LiOH (720 mg, 30.1 mmol) in water (2 mL) was added and the reaction mixture was heated at 50° C. for 2 hours.", "The reaction mixture was evaporated to dryness and coevaporated with toluene (2×50 mL) to afford a beige powder.", "Half of the above obtained powder was dissolved in DMF (10 mL).", "Triethylamine hydrochloride (2349 mg, 17.1 mmol), triethylamine (1.19 mL) and HATU (1298 mg, 3.41 mmol), were added and the reaction mixture was stirred at room temperature for 10 minutes.", "4-Fluoro-3-methylaniline (712 mg, 5.688 mmol), was added to the reaction mixture which was stirred at room temperature for 3 hours.", "The reaction mixture was poured into water and the solids were filtered and washed with water to afford a beige solid which was purified using silica gel column chromatography (ethylacetate in heptane from 0 to 100%) to afford compound 89 as a white powder.", "Method B; Rt: 0.92 min.", "m/z: 394.1 (M−H)− Exact mass: 395.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.50 (s, 3H), 2.22 (d, J=1.6 Hz, 3H), 2.43 (s, 3H), 3.83 (s, 3H), 4.11 (d, J=6.5 Hz, 2H), 4.59 (d, J=6.1 Hz, 2H), 6 7.08 (t, J=9.3 Hz, 1H), 7.29 (s, 1H), 7.49-7.54 (m, 1H), 7.63 (dd, J=7.3, 2.4 Hz, 1H), 7.92 (s, 1H), 9.94 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 186.6° C. Compound 90: N-(4-Fluoro-3-methylphenyl)-1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Ethyl 1,3-dimethylpyrrole-2-carboxylate (1.3 g, 7.78 mmol) was added drop wise to chlorosulfonic acid (5.2 mL) at 0° C. under nitrogen atmosphere.", "The reaction mixture was warmed to room temperature and allowed to stir 1.5 hours.", "The reaction mixture was slowly added to ice cold water, followed by extraction with CH2Cl2.The combined organic extracts were dried (Na2SO4) and concentrated in crude ethyl 4-chlorosulfonyl-1,3-dimethyl-pyrrole-2-carboxylate (1300 mg) as a brown oil.", "Crude ethyl 4-chlorosulfonyl-1,3-dimethyl-pyrrole-2-carboxylate (1.3 g, 4.89 mmol) was dissolved in acetonitrile (5 mL) and 3-methyl-3-oxetanamine (852 mg, 9.79 mmol) was added followed by Hunig's base (2.11 mL, 12.23 mmol).", "The reaction mixture was stirred at room temperature for 1 hour.", "The reaction mixture was filtered.", "The solids were washed with CH2Cl2 and discarded.", "The filtrate was evaporated and the residue was purified using silica gel column chromatography ethyl acetate in heptane from 0 to 100% resulting in ethyl 1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylate (302 mg) as sticky oil.", "Method B; Rt: 0.79 min.", "m/z: 315.1 (M−H)− Exact mass: 316.1.Ethyl 1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylate (302 mg, 0.955 mmol) was dissolved in THF (40 mL) and LiOH (114.3 mg, 4.77 mmol) in water (10 mL) was added.", "The reaction mixture was stirred at room temperature.", "Methanol (20 mL) was added to the reaction mixture.", "The reaction mixture was stirred at room temperature overnight.", "More LiOH (5 equiv.)", "in water was added and the reaction mixture was heated at 60° C. for 42 hours.", "The reaction mixture was evaporated to dryness and coevaporated with toluene (2×50 mL).", "The residue was used as such in next step.", "The obtained residue was dissolved in DMF (10 mL).", "triethylamine hydrochloride (1575 mg, 11.4 mmol), triethylamine (0.663 mL, 4.7 mmol) and HATU (435 mg, 1.15 mmol) were added and the reaction mixture was stirred at room temperature for 10 minutes.", "4-fluoro-3-methylaniline (239 mg, 1.91 mmol) was added to the reaction mixture which was stirred at room temperature for 2 hours.", "The reaction mixture was stirred at 50° C. for 2 hours.", "Water was added to the reaction mixture and the mixture was extracted with 2-Methyl THF.", "The combined organic layers were washed with brine, dried (Na2SO4) and evaporated to afford a brown oil.", "The oil was purified using silica gel column chromatography (ethylacetate in heptane from 0 to 100%) to afford a sticky light brown oil.", "Compound 90 was purified using Preparative LC (Hypersyl C18 BDS-3 μm, 100×4.6 mm) Mobile phase (NH4HCO3 0.2% in water, methanol) the desired fractions were combined and evaporated to dryness, dissolved in methanol and evaporated to dryness.", "After drying in vacuo compound 90 was obtained as a white powder.", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.53 (s, 3H), 2.23 (d, J=1.6 Hz, 3H), 2.31 (s, 3H), 3.70 (s, 3H), 4.11 (d, J=6.5 Hz, 2H), 4.61 (d, J=5.7 Hz, 2H), 6 7.11 (t, J=9.3 Hz, 1H), 7.44 (s, 1H), 7.47-7.53 (m, 1H), 7.62 (dd, J=6.9, 2.4 Hz, 1H), 7.88 (br.", "s., 1H), 10.09 (s, 1H).", "Method B; Rt: 0.88 min.", "m/z: 394.2 (M−H)− Exact mass: 395.1.Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 160.5° C. Compound 97: N-(4-Fluoro-3-methylphenyl)-1-methyl-4-{[(1R)-1-methyl-2-(methyl-sulfonyl)ethyl]sulfamoyl}-1H-pyrrole-2-carboxamide 5-[(4-fluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (0.269 g, 0.813 mmol) was stirred in acetonitrile (50 mL).", "Et3N (0.339 mL, 2.44 mmol) and (2R)-1-methylsulfonylpropan-2-amine (0.123 g, 0.895 mmol) were added under N2-atmosphere at room temperature.", "The reaction mixture was stirred for 22 hours and next concentrated.", "The compound was precipitated from CH2Cl2/MeOH (4 mL, 3:1).", "The precipitate was filtered off, washed with CH2Cl2 (2×3 mL) and dried in vacuo at 50° C., resulting in compound 97 (123 mg).", "Method A; Rt: 1.47 min.", "m/z: 430.1 (M−H)− Exact mass: 431.1.1H NMR (400 MHz, DMSO-d6, 80° C.) δ ppm 1.20 (d, J=6.6 Hz, 3H), 2.22 (d, J=1.8 Hz, 3H), 2.94 (s, 3H), 3.10-3.17 (m, 1H), 3.27-3.34 (m, 1H), 3.71-3.81 (m, 1H), 3.92 (s, 3H), 7.04 (t, J=9.2 Hz, 1H), 7.30 (d, J=1.8 Hz, 2H), 7.46-7.52 (m, 2H), 7.59 (dd, J=7.3, 2.6 Hz, 1H), 9.80 (br.", "s., 1H).", "Compound 98: 4-(tert-Butylsulfamoyl)-N-[4-fluoro-3-(trifluoromethoxy)phenyl]-1-methyl-1H-pyrrole-2-carboxamide 4-fluoro-3-(trifluoromethoxy)aniline (991 mg, 5.08 mmol) dissolved in toluene (10 mL) was added to 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride (1.23 g, 5.079 mmol) in toluene (65 mL) at reflux and refluxed 2 hours.", "The reaction mixture was filtered while still hot and concentrated yielding crude 5-[[4-fluoro-3-(trifluoromethoxy)phenyl]carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride as a beige powder which was used as such.", "1H NMR (400 MHz, acetonitrile-d3) δ ppm 3.97 (s, 3H), 7.27-7.35 (m, 1H), 7.38 (d, J=2.0 Hz, 1H), 7.57 (ddd, J=9.0, 4.0, 2.6 Hz, 1H), 7.73 (d, J=1.5 Hz, 1H), 7.87-7.94 (m, 1H), 8.79 (br.", "s., 1H).", "Tert-butylamine (342.7 mg, 4.69 mmol) was added to crude 5-[[4-fluoro-3-(trifluoromethoxy)phenyl]carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (626 mg) in acetonitrile (52 mL) and stirred 2 hours.", "Water was added until crystallisation began.", "The white crystals were filtered off and dried in vacuo at 50° C. during 4 hours.", "Method A; Rt: 1.90 min.", "m/z: 436.1 (M−H)− Exact mass: 437.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (s, 9H), 3.91 (s, 3H), 7.12 (s, 1H), 7.33 (d, J=1.8 Hz, 1H), 7.48 (s, 1H), 7.54 (d, J=1.5 Hz, 1H), 7.69-7.77 (m, 1H), 7.98-8.07 (m, 1H), 10.28 (s, 1H).", "Compound 99: N-(2,4-Difluoro-3-methylphenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide 4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxylic acid (0.426 g, 1.73 mol) was dissolved in acetonitrile (40 mL).", "Et3N (0.962 mL, 6.92 mmol) and 2,4-difluoro-3-methyl-aniline (0.342 g, 1.9 mmol) were added.", "HATU (0.789 g, 2.08 mmol) was next added at once.", "The reaction mixture was stirred at room temperature for 1 hour.", "Then the solution was stirred at 50° C. for 80 hours.", "The solution was allowed to cool and water (2×50 mL) and brine (5 mL) were added.", "The solution was extracted with EtOAc (2×100 mL) and dried with Na2SO4.The solvent was evaporated leaving yellow oil which purified by silica gel chromatography (EtOAc-heptane 0/100 to 100/0).", "The obtained solid was dissolved in boiling 2-propanol (1.5 mL) and water was added dropwise (1.5 mL) when still boiling.", "The solution was allowed to cool down After 90 min the white precipitate was filtered off, washed with 2-Propanol/water (2×1 mL) and dried at 50° C. in vacuo yielding compound 99 as white crystals.", "Method A; Rt: 1.72 min.", "m/z: 370.0 (M−H)− Exact mass: 371.1.1H NMR (400 MHz, DMSO-d6, 80° C.) δ ppm 1.06 (d, J=6.4 Hz, 6H), 2.18 (t, J=1.9 Hz, 3H), 3.33 (dt, J=13.0, 6.6 Hz, 1H), 3.89 (s, 3H), 6.85 (br.", "s., 1H), 7.00 (td, J=8.9, 1.8 Hz, 1H), 7.25 (s, 1H), 7.37 (m, J=8.8, 8.8, 6.2 Hz, 1H), 7.43 (d, J=1.8 Hz, 1H), 9.62 (br.", "s., 1H) Synthesis of 1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid Methyl 4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate (5 g, 21.04 mmol) was dissolved in acetonitrile (50 mL).", "To this was added diisopropylethylamine (9.06 mL, 52.6 mmol) followed by (S)-1,1,1-trifluoro-2-propylamine (3.57 g, 31.6 mmol) and the resulting mixture was refluxed overnight.", "Then the mixture was cooled to room temperature and concentrated in vacuo.", "The resulting residue was dissolved in dichloromethane (250 mL) and this was washed with HCl (2×150 mL).", "The organics were dried on sodium sulphate, filtered and concentrated in vacuo yielding crude methyl 1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (6.6 g) which was used as such.", "Methyl 1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (6.6 g, 19.7 mmol) was dissolved in tetrahydrofuran (56 mL).", "To this was added lithium hydroxide (1.655 g, 69.1 mmol) in distilled water (7.5 mL) followed by methanol (3 mL).", "The resulting mixture was stirred overnight.", "The mixture was concentrated until only water remained and extra distilled water (15 mL) was added.", "The mixture was neutralised with hydrochloric acid (1M, aq).", "The resulting mixture was extracted using 2-methyltetrahydrofuran (3×20 mL).", "The combined extracts were dried on sodium sulphate, filtered and concentrated in vacuo yielding 1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid (5.34 g).", "Compound 100 to 105 were prepared similarly as described for compound 80, using 1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid instead of 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylic acid and the corresponding aniline instead of 4-fluoro-3,5-dimethylaniline.", "After addition of the aniline, the mixture was stirred at 50° C. for 6 hours instead of 24 hours at room temperature.", "Compound 100: N-(3-Bromo-4,5-difluorophenyl)-1-methyl-4-{(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Crude compound 100 was purified by silica gel chromatography heptane-EtOAc 100/0 to 0/100.The product was crystallized from diisopropylether (15 mL)/iPrOH (3.5 mL).", "The product was filtered off, washed with diisopropylether (3×), and dried at 50° C. in vacuo, resulting in compound 100 (251 mg).", "Method A; Rt: 1.98 min.", "m/z: 489.8 (M−H)− Exact mass: 491.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.08 (d, J=6.8 Hz, 3H), 3.84-4.00 (m, 4H), 7.36 (d, J=2.0 Hz, 1H), 7.66 (d, J=1.8 Hz, 1H), 7.80-7.93 (m, 2H), 8.20 (br.", "s., 1H), 10.31 (br.", "s., 1H).", "19F NMR (377 MHz, DMSO-d6) δ ppm −138.51-−138.34 (m, 1 F), −133.99-−133.81 (m, 1 F), -76.07 (d, J=7.9 Hz, 3 F).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 199.0° C. Compound 101: N-(3-Bromo-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Crude compound 101 was stirred in CH2Cl2 (5 mL), filtered off, and washed with CH2Cl2 (1×).", "The product (0.289 g) was crystallized from iPrOH—H2O 3/1 (6 mL), filtered off, washed with iPrOH—H2O 3/1 (3×), and dried at 50° C. in vacuo, resulting in compound 101 (70 mg).", "Method B; Rt: 1.07 min.", "m/z: 470.0 (M−H)− Exact mass: 471.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.08 (d, J=7.0 Hz, 3H), 3.88-3.96 (m, 4H), 7.33-7.41 (m, 2H), 7.63 (d, J=1.5 Hz, 1H), 7.71 (ddd, J=9.0, 4.4, 2.6 Hz, 1H), 8.11-8.28 (m, 2H), 10.21 (s, 1H).", "Compound 102: N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Crude compound 102 was stirred in CH2Cl2 (5 mL), filtered off, and washed with CH2Cl2 (2×).", "The product was crystallized from iPrOH (12.5 mL)+H2O (2.5 mL), filtered off, washed with iPrOH—H2O 4/1 (2×) and iPrOH, and dried at 50° C. in vacuo, resulting in compound 102 (93 mg).", "Method B; Rt: 0.97 min.", "m/z: 417.1 (M−H)− Exact mass: 418.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.07 (d, J=7.0 Hz, 3H), 3.84-3.99 (m, 4H), 7.36 (d, J=2.0 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.64 (br.", "s., 1H), 7.97-8.04 (m, 1H), 8.22 (dd+br.", "s., J=5.7, 2.6 Hz, 2H), 10.38 (br.", "s., 1H).", "Alternative Synthesis of Compound 102: Methyl 1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (5 g, 15.9 mmol) was dissolved in of dry tetrahydrofuran (50 mL) under a blanket of nitrogen.", "5-amino-2-fluorobenzonitrile (2.82 g, 20.68 mmol) was added and the mixture was cooled in an ice-water bath while stirring under nitrogen.", "Lithium bis(trimethylsilyl)amide (1M in toluene, 47.73 mL, 47.73 mmol) was added drop wise over a period of 10 minutes.", "The resulting mixture was stirred for 1 hour while cooling was continued.", "An extra 2 equivalents of lithium bis(trimethylsilyl)amide (1M in toluene, 31.82 mL, 31.82 mmol) were added drop wise over a period of 10 minutes.", "The resulting mixture was stirred for 1 hour while cooling was continued.", "An extra equivalent of lithium bis(trimethylsilyl)amide (1M in toluene, 15.9 mL, 15.9 mmol) was added drop wise over a period of 5 minutes.", "Next, the mixture was quenched with saturated ammonium chloride (150 mL/aq) and the resulting mixture was extracted using EtOAc (3×150 mL).", "The combined extracts were washed with brine (200 mL), dried on Na2SO4, filtered and concentrated in vacuo.", "The obtained residue was dissolved in dichloromethane (10 mL) and this was loaded on a dry silica plug (330 g).", "This was purified by column chromatography using gradient elution from heptane to EtOAc.", "(100:0 to 0:100).", "The desired fractions were collected and concentrated in vacuo yielding a slightly red powder.", "This powder was recrystallized out of MeOH/water.", "The obtained crystals were collected on a filter, rinsed with water and diisopropylether and dried in a vacuum oven at 55° C. for 24 hours yielding compound 102 (3.92 g) as a bright white powder.", "[α]58920=+2.7° (c 0.96 w/v %, MeOH).", "[α]58920=+21.8° (c 0.37 w/v %, DMF).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 213.4° C. SFC analysis: AD-H 250 mm×4.6 mm, Flow: 5 mL/min Mobile phase: 10-55% MeOH (containing 0.2% iPrNH2) @ 14.5% rate, down to 50% and hold for 2.55 min @ 50%, Temperature: 40° C.: Compound 102 (first eluding), containing no detectable compound 157 (second eluding).", "1H NMR (600 MHz, DMSO-d6) δ ppm 1.08 (d, J=7.0 Hz, 3H), 3.88-3.97 (m, 1H), 3.93 (s, 3H), 7.37 (d, J=1.9 Hz, 1H), 7.53 (t, J=9.2 Hz, 1H), 7.67 (d, J=1.9 Hz, 1H), 8.01 (ddd, J=9.2, 4.8, 2.7 Hz, 1H), 8.19 (br.", "s., 1H), 8.22 (dd, J=5.8, 2.7 Hz, 1H), 10.39 (br.", "s., 1H).", "Compound 103: N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Crude compound 103 was triturated from refluxing CH2Cl2 (10 mL).", "The suspension was cooled to room temperature, the solids were filtered and washed with CH2Cl2 (2 mL) resulting in compound 103 (308 mg) as white solid after drying in vacuo at 50° C. Method B; Rt: 1.13 min.", "m/z: 444.0 (M−H)− Exact mass: 445.0.III NMR (400 MHz, DMSO-d6) δ ppm 1.08 (d, J=6.8 Hz, 3H), 3.85-3.98 (m, 4H), 7.36 (d, J=1.5 Hz, 1H), 7.65 (d, J=1.3 Hz, 1H), 7.75-7.87 (m, 2H), 8.19 (br.", "s, 1H), 10.33 (br.", "s., 1H).", "Compound 104: N-(3,4-Difluoro-5-methylphenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Crude compound 104 was triturated from refluxing CH2Cl2 (10 mL).", "The suspension was cooled to room temperature, the solids were filtered and washed with CH2Cl2 (2 mL) resulting in compound 104 (481 mg) as white solid after drying in vacuo at 50° C. Method B; Rt: 1.08 min.", "m/z: 424.0 (M−H)− Exact mass: 425.1.III NMR (400 MHz, DMSO-d6) δ ppm 1.07 (d, J=7.0 Hz, 3H), 2.28 (d, J=2.0 Hz, 3H), 3.86-3.98 (m, 4H), 7.34 (d, J=2.0 Hz, 1H), 7.38-7.44 (m, 1H), 7.62 (d, J=1.3 Hz, 1H), 7.66 (ddd, J=12.9, 7.1, 2.4 Hz, 1H), 8.16 (br.", "s., 1H), 10.15 (s, 1H).", "Compound 105: N-(3-Chloro-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Crude compound 105 was triturated from refluxing CH2Cl2 (10 mL).", "The suspension was cooled to room temperature, the solids were filtered and washed with CH2Cl2 (2 mL).", "The obtained solid was triturated with warm acetonitrile, the mixture was cooled to room temperature.", "The solids were filtered and to the obtained filtrate, water (3 mL) was added to form a white solid which was filtered and washed with water, resulting in compound 105 as white powder.", "Method B; Rt: 1.08 min.", "m/z: 426.0 (M−H)− Exact mass: 427.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.08 (d, J=7.0 Hz, 3H), 3.87-3.98 (m, 4H), 7.35 (d, J=2.0 Hz, 1H), 7.40 (t, J=9.1 Hz, 1H), 7.60-7.70 (m, 2H), 8.01 (dd, J=6.9, 2.5 Hz, 1H), 8.16 (br.", "s., 1H), 10.23 (s, 1H).", "Compound 94: 3-Fluoro-N-(4-fluoro-3-methylphenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide A solution of Et3N (0.179 mL, 1.29 mmol) in DMF (1.9 mL) was added to 3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylic acid 1125 mg, 0.428 mmol), HATU (204 mg, 0.535 mmol), 4-fluoro-3-methylaniline (107 mg, 0.857 mmol) and stirred overnight.", "The solution was subjected to column chromatography using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were combined and concentrated.", "Compound 94 (78 mg) was obtained as a white powder after drying in vacuo at 50° C. Method A; Rt: 1.66 min.", "m/z: 397.9 (M−H)− Exact mass: 399.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.56 (s, 3H), 2.23 (d, J=1.5 Hz, 3H), 3.79 (s, 3H), 4.17 (d, J=6.4 Hz, 2H), 4.65 (d, J=6.2 Hz, 2H), 7.10 (t, J=9.2 Hz, 1H), 7.43-7.51 (m, 2H), 7.59 (dd, J=7.0, 2.4 Hz, 1H), 8.28 (s, 1H), 10.01 (s, 1H).", "Compound 106: N-(3-Bromo-4-fluorophenyl)-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 106 (131 mg) was prepared similarly as described for compound 94, using 3-bromo-4-fluoroaniline instead of 4-fluoro-3-methylaniline.", "Method A; Rt: 1.73 min.", "m/z: 463.8 (M−H)− Exact mass: 465.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.56 (s, 3H), 3.80 (s, 3H), 4.17 (d, J=6.4 Hz, 2H), 4.64 (d, J=5.9 Hz, 2H), 7.37 (t, J=8.8 Hz, 1H), 7.51 (d, J=4.4 Hz, 1H), 7.64 (ddd, J=9.0, 4.4, 2.6 Hz, 1H), 8.08 (dd, J=6.4, 2.6 Hz, 1H), 8.30 (s, 1H), 10.20 (s, 1H).", "Compound 107: N-[3-(Difluoromethyl)-4-fluorophenyl]-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 107 (149 mg) was prepared similarly as described for compound 94, using 3-(difluoromethyl)-4-fluoro-aniline instead of 4-fluoro-3-methylaniline.", "Method A; Rt: 1.63 min.", "m/z: 334.0 (M−H)− Exact mass: 435.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.56 (s, 3H), 3.80 (s, 3H), 4.18 (d, J=6.6 Hz, 2H), 4.65 (d, J=5.9 Hz, 2H), 7.04-7.43 (m, 2H), 7.51 (d, J=4.6 Hz, 1H), 7.76-7.86 (m, 1H), 8.01 (dd, J=6.3, 2.5 Hz, 1H), 8.30 (s, 1H), 10.26 (s, 1H).", "Compound 108: N-(3-Chloro-4-fluorophenyl)-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 108 (149 mg) was prepared similarly as described for compound 94, using 3-chloro-4-fluoroaniline instead of 4-fluoro-3-methylaniline.", "Method A; Rt: 1.70 min.", "m/z: 417.9 (M−H)− Exact mass: 419.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.56 (s, 3H), 3.80 (s, 3H), 4.17 (d, J=6.4 Hz, 2H), 4.64 (d, J=6.2 Hz, 2H), 7.41 (t, J=9.1 Hz, 1H), 7.51 (d, J=4.4 Hz, 1H), 7.60 (ddd, J=9.1, 4.3, 2.6 Hz, 1H), 7.96 (dd, J=6.8, 2.4 Hz, 1H), 8.30 (s, 1H), 10.22 (s, 1H).", "Compound 109: 3-Fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-N-(2,4,5-trifluorophenyl)-1H-pyrrole-2-carboxamide Compound 109 (35 mg) was prepared similarly as described for compound 94, using 2,4,5-trifluoroaniline instead of 4-fluoro-3-methylaniline.", "After overnight stirring at room temperature, the mixture was stirred at 60° C. for 3 hours.", "Method A; Rt: 1.56 min.", "m/z: 420.1 (M−H)− Exact mass: 421.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.55 (s, 3H), 3.81 (s, 3H), 4.17 (d, J=6.4 Hz, 2H), 4.64 (d, J=5.9 Hz, 2H), 7.53 (d, J=4.6 Hz, 1H), 7.67 (td, J=10.6, 7.3 Hz, 1H), 7.80-7.90 (m, 1H), 8.32 (s, 1H), 9.79 (s, 1H).", "Compound 110: N-(2,4-Difluoro-3-methylphenyl)-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 110 (90 mg) was prepared similarly as described for compound 94, using 2,4-difluoro-3-methyl-aniline instead of 4-fluoro-3-methylaniline.", "Method A; Rt: 1.68 min.", "m/z: 415.9 (M−H)− Exact mass: 417.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.56 (s, 3H), 2.15-2.22 (m, 3H), 3.80 (s, 3H), 4.17 (d, J=6.4 Hz, 2H), 4.65 (d, J=6.2 Hz, 2H), 7.06 (td, J=9.0, 1.5 Hz, 1H), 7.46-7.56 (m, 2H), 8.30 (s, 1H), 9.63 (s, 1H).", "Compound 111: N-(3-Chloro-4,5-difluorophenyl)-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 111 (46 mg) was prepared similarly as described for compound 94, using 3-chloro-4,5-difluoro-aniline instead of 4-fluoro-3-methylaniline.", "The mixture was stirred at 65° C. overnight instead of room temperature.", "Method A; Rt: 1.80 min.", "m/z: 435.9 (M−H)− Exact mass: 437.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.55 (s, 3H), 3.80 (s, 3H), 4.17 (d, J=6.4 Hz, 2H), 4.64 (d, J=6.2 Hz, 2H), 7.54 (d, J=4.4 Hz, 1H), 7.70-7.80 (m, 2H), 8.32 (s, 1H), 10.30 (s, 1H).", "Compound 112: 4-(tert-butylsulfamoyl)-N-(2,4-difluoro-3-methyl-phenyl)-1-methyl-pyrrole-2-carboxamide 5-[(2,4-difluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (prepared similarly as described for 5-[(3,4-difluorophenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride, using 2,4-difluoro-3-methyl-aniline instead of 3,4-difluoroaniline; 0.25 g, 0.72 mmol) was stirred in acetonitrile (20 mL).", "DIPEA (0.494 mL, 2.87 mmol) and tert-butylamine (0.152 mL, 1.43 mmol) were added under N2-atmosphere at room temperature.", "The reaction mixture was stirred in a sealed tube at 80° C. for 5 hours and further at room temperature for more than 80 hours.", "The solvent was evaporated and the residue was dissolved in (CH2Cl2/MeOH (5 mL, 90:10) and purified by silica gel chromatography [EtOAc-heptane 0/100 to 100/0] and further purified by reverse phase column chromatography.", "The resulting solid was triturated from Heptane/diisopropyl ether (4:1, 2.5 mL).", "The formed suspension was filtered.", "The filtercake was washed with heptane/diisopropylether (4:1, 5 mL) and dried at 50° C. in vacuo yielding compound 112 (120 mg) as a white solid.", "Method A; Rt: 1.71 min.", "m/z: 384.1 (M−H)− Exact mass: 385.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (s, 9H), 2.18 (s, 3H), 3.88 (s, 3H), 7.05 (td, J=8.9, 1.5 Hz, 1H), 7.12 (s, 1H), 7.29 (s, 1H), 7.34 (td, J=8.7, 6.3 Hz, 1H), 7.50 (d, J=1.8 Hz, 1H), 9.89 (s, 1H).", "Compound 113: N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide Compound 113 (43 mg) was prepared similarly as described for compound 94, using 5-amino-2-fluoro-benzonitrile instead of 4-fluoro-3-methylaniline but stirred 24 hours at 65° C. and 48 hours at 100° C. The residue after column was crystallized from acetonitrile (10 mL) upon addition of water.", "The crystals were dried overnight at 50° C. in vacuo.", "Method A; Rt: 1.44 min.", "m/z: 409.0 (M−H)− Exact mass: 410.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.56 (s, 3H), 3.80 (s, 3H), 4.18 (d, J=6.4 Hz, 2H), 4.64 (d, J=5.9 Hz, 2H), 7.48-7.58 (m, 2H), 7.96 (ddd, J=9.2, 4.8, 2.6 Hz, 1H), 8.16 (dd, J=5.7, 2.6 Hz, 1H), 8.32 (s, 1H), 10.34 (s, 1H).", "Compound 114: 4-[(1-Carbamoylcyclopropyl)sulfamoyl]-N-(3-chloro-4,5-difluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide Methyl 1-aminocyclopropanecarboxylate (1.016 g, 6.7 mmol) was dissolved in dry dichloromethane (50 ml) and dry DIPEA (3.08 ml) under N2-atm.", "5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (prepared similarly as described for compound 57, 1.65 g, 4.47 mmol) was added.", "The reaction mixture was stirred at room temperature for 3 h. Dry DMF (1 mL) was added and the reaction mixture was stirred for 22 h. Then the mixture was washed with HCl 1M (50 mL).", "The layers were separated, precipitate 1 was filtered off and washed with CH2Cl2 (10 mL).", "The organic layer was dried with Na2SO4 and the filtrate was evaporated resulting in residue 1.The water layer was extracted with EtOAc (100 mL).", "The layers were separated and the organic layer was dried with Na2SO4 and the filtrate was evaporated resulting in residue 2.Residue 1, 2 and precipitate 1 were combined giving methyl 1-[[5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrol-3-yl]sulfonylamino]-cyclopropanecarboxylate (2.0 g) This material was dissolved in methanol (20 mL) and NaOH 1M (13.4 mL, 13.4 mmol) was added.", "The reaction mixture was stirred for 20 h. After 8 h, THF (6 mL) was added and the mixture was stirred further for 18 h. Then the mixture was successively stirred at 50° C. for 9 h, room temperature for 80 h, 50° C. for 8 h and 18 h at room temperature.", "The methanol/THF was distilled off and the mixture was extracted with Et2O.", "The layers were separated and HCl 1M (14 mL) was added to the water layer.", "The water layer was extracted with MeTHF.", "The organic layer was evaporated resulting in 1-[[5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrol-3-yl]sulfonylamino]cyclopropanecarboxylic acid as a yellow residue (1164 mg) which was used as such.", "This material (700 mg, 16.1 mmol) was stirred in CH3CN (50 mL), CDI (654 mg, 40.3 mmol) was added and the resulting solution was stirred at room temperature in a sealed tube for 2.5 h [white precipitation was observed].", "Then, NH3 (0.4 M in THF, 80.7 mL, 32.3 mmol) was added at once.", "The mixture was stirred at room temperature for more than 80 h. The solvent was evaporated and the yellow residue was dissolved in EtOAc (80 mL).", "The solution was washed with HCl 1M (50 mL) and saturated NaCl solution (5 mL).", "The layers were separated and the organic was dried with Na2SO4.The solvent was evaporated and the beige residue was stirred in warm CH3CN.", "The suspension was filtered off leaving a white filtercake.", "The filtercake was washed with CH3CN and dried in vacuo at 50° C., resulting in compound 114 (319 mg) Method A; Rt: 1.56 min.", "m/z: 431.0 (M−H)− Exact mass: 432.05.1H NMR (400 MHz, DMSO-d6) δ ppm 0.94-0.99 (m, 2H), 1.10-1.18 (m, 2H), 3.91 (s, 3H), 6.87 (br.", "s., 1H), 7.21 (br.", "s., 1H), 7.32 (d, J=1.8 Hz, 1H), 7.59 (d, J=1.8 Hz, 1H), 7.76-7.87 (m, 2H), 8.20 (br.", "s., 1H), 10.29 (br.", "s., 1H).", "Compound 115: N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-{[1-(methylcarbamoyl)cyclopropyl]sulfamoyl}-1H-pyrrole-2-carboxamide 1-[[5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrol-3-yl]sulfonylamino]-cyclopropanecarboxylic acid (364 mg, 0.839 mmol) was stirred in dry CH3CN (30 mL).", "After addition of CDI (340 mg, 2.1 mmol) the mixture became a solution.", "The reaction mixture was stirred at room temperature in a sealed tube for 2.5 h. Then Methylamine (2 M in THF, 12 mL, 24 mmol) was added at once.", "The mixture was stirred at room temperature for 2 h. The reaction was stirred during 80 h. The solvent was distilled off and the residue dissolved in 5 mL CH2Cl2/MeOH (90:10) and purified by flash chromatography on silica using a gradient EtOAc-heptane 0/100 to 100/0.The desired fractions were combined and the solvent was evaporated, resulting in compound 115 (199 mg) Method A; Rt: 1.60 min.", "m/z: 445.0 (M−H)− 447.0 (M+H)+ Exact mass: 446.10.1H NMR (400 MHz, DMSO-d6) δ ppm 0.91-0.98 (m, 2H), 1.08-1.15 (m, 2H), 2.55 (d, J=4.6 Hz, 3H), 3.91 (s, 3H), 7.31 (d, J=2.0 Hz, 1H), 7.41 (d, J=4.6 Hz, 1H), 7.58 (d, J=1.5 Hz, 1H), 7.76-7.86 (m, 2H), 8.14 (br.", "s., 1H), 10.31 (br.", "s., 1H).", "Compound 116: N-(2,4-Difluoro-3-methylphenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide 5-[(2,4-difluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (310 mg, 0.89 mmol) prepared similarly as described in the synthesis for compound 57 using 2,4-difluoro-3-methyl-aniline (251 mg, 2.22 mmol) was stirred in dry CH3CN (25 mL).", "(2R)-1,1,1-trifluoropropan-2-amine (251 mg, 2.22 mmol) was added under N2-atm at room temperature.", "The mixture was stirred in a sealed tube at 75° C. for 42 hours.", "Then the reaction mixture was concentrated, water was added (8 mL) and the formed precipitate was filtered off and washed with water/CH3CN (10 mL 5:1).", "The obtained red solid was suspended in boiling diisopropyl ether (3 mL) and 2-propanol (2 mL) was added dropwise.", "The mixture was left standing for 90 min and then filtered.", "The precipitate was washed with diisopropyl ether/2-propanol (4:1, 6 mL) and dried in vacuo at 50° C. yielding compound 116 as a slightly red-purple solid (240 mg) Method A; Rt: 1.71 min.", "m/z: 424.0 (M−H)− 426.0 (M+H)+ Exact mass: 425.08.1H NMR (360 MHz, DMSO-d6) δ ppm 1.08 (d, J=7.0 Hz, 3H), 2.18 (s, 3H), 3.87-3.97 (m, 4H), 7.07 (td, J=9.0, 1.5 Hz, 1H), 7.31-7.39 (m, 2H), 7.64 (d, J=1.8 Hz, 1H), 8.18 (br.", "s., 1H), 9.95 (s, 1H) Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 206.64° C. Compound 117: N-(2,4-Difluoro-3-methylphenyl)-1-methyl-4-{[1-(trifluoromethyl)-cyclopropyl]sulfamoyl}-1H-pyrrole-2-carboxamide 5-[(2,4-difluoro-3-methyl-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (310 mg, 0.89 mmol) was stirred in dry acetonitrile (25 mL) and dry DIPEA (0.61 mL, 3.56 mmol).", "1-(trifluoromethyl)cyclopropanamine (222 mg, 1.78 mmol) was added under N2-atm at room temperature.", "The reaction mixture was stirred in a sealed tube at 75° C. for 24 h and 110 h at 95° C. Then 1 eq of 1-(trifluoromethyl)cyclopropanamine was added and the mixture was stirred at 95° for 24 h. The solvent was evaporated leaving yellow oil which was dissolved in CH2Cl2/Methanol (80/20; 5 mL) and purified by Flash Chromatography [Biotage Isolera 1//GraceResolve Silica 12 g//EtOAc-heptane 0/100 to 100/0].", "The desired fractions were combined and the solvent was evaporated leaving a red colored solid, which was dissolved in a boiling mixture of 2 mL of diisopropyl ether and 3 mL of CH3CN.", "The solution was allowed to cool while stirring.", "After 45 min the formed precipitate was filtered off and was washed once with its own filtrate and at the end with 2 mL of diisopropyl ether.", "The white solid was dried in vacuo at 50° C. Method B; Rt: 1.01 min.", "m/z: 436.0 (M−H)− Exact mass: 437.08.1H NMR (360 MHz, DMSO-d6) δ ppm 1.08-1.22 (m, 4H), 2.18 (s, 3H), 3.88 (s, 3H), 7.07 (td, J=9.0, 1.5 Hz, 1H), 7.27 (d, J=1.8 Hz, 1H), 7.34 (td, J=8.8, 6 6.2 Hz, 1H), 7.56 (d, J=1.8 Hz, 1H), 8.76 (br.", "s., 1H), 9.95 (s, 1H).", "Compound 118: N-(2,4-Difluoro-3-methylphenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide The compound was prepared similarly as compound 117 using 2.5 eq of 1,1,1-trifluoro-2-methyl-propan-2-amine instead of 1-(trifluoromethyl)cyclopropanamine.", "The reaction mixture was stirred in a sealed tube at 75° C. for 18 h and for 80 h at 95° C. Method B; Rt: 1.01 min.", "m/z: 438.0 (M−H)− Exact mass: 439.10.1H NMR (400 MHz, DMSO-d6) δ ppm 1.37 (s, 6H), 2.19 (s, 3H), 3.90 (s, 3H), 7.06 (td, J=9.0, 1.4 Hz, 1H), 7.28-7.39 (m, 2H), 7.56 (d, J=1.8 Hz, 1H), 6 8.05 (br.", "s., 1H), 9.94 (s, 1H) Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 164.23° C. Compound 119: N-(2,4-Difluoro-3-methylphenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide The compound was prepared similarly as compound 117 using (2S)-1,1,1-trifluoropropan-2-amine instead of 1-(trifluoromethyl)cyclopropanamine, the reaction mixture was stirred in a sealed tube for 42 h at 95° C. Then the reaction mixture was concentrated and water was added (8 mL) and the formed precipitate was filtered off and dried in vacuo at 50° C. yielding compound 119 as a powder.", "Method A; Rt: 1.71 min.", "m/z: 424.0 (M−H)− Exact mass: 425.08.1H NMR (400 MHz, DMSO-d6) δ ppm 1.09 (d, J=7.0 Hz, 3H), 2.18 (s, 3H), 3.87-3.98 (m, 4H), 7.06 (td, J=8.9, 1.5 Hz, 1H), 7.30-7.40 (m, 2H), 7.63 (d, J=1.8 Hz, 1H), 8.16 (d, J=8.6 Hz, 1H), 9.92 (s, 1H) Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 207.52.Compound 120: N-(3-Chloro-2,4-difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide 5-[(3-chloro-2,4-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (900 mg, 2.44 mmol) prepared similarly as in the synthesis for compound 57 using 3-chloro-2,4-difluoro-aniline (3.5 g, 14.46 mmol) was stirred in dry CH3CN (10 mL).", "(2R)-1,1,1-trifluoropropan-2-amine (689 mg, 6.1 mmol) was added under N2-atm at room temperature.", "The reaction mixture was stirred in a sealed tube at 85° C. for 6 h and left standing for 18 h. The solvent was evaporated and the red residue was suspended in DCM.", "The formed precipitate was filtered off and dried under vacuum at 50° C. The filtrate was concentrated till precipitation took place.", "The formed precipitate was filtered off.", "The combined precipitates were recrystallized in DIPE/ACN (1:1; 6 mL), left stirring for 2 h then left standing for 18 h, filtered off and dried under vacuum at 50° C. The filtrate was left standing for 18 h. The formed precipitate was filtered off and dried under vacuum at 50° C. The obtained white solid was recrystallized in DIPE/ACN (1:1; 4 mL), left stirring for 2 h then left standing for 18 h, filtered off and dried under vacuum at 50° C. The 2 solids were combined (394 mg).", "Method A; Rt: 1.85 min.", "m/z: 444.0 (M−H)− Exact mass: 445.03.1H NMR (400 MHz, DMSO-d6) δ ppm 1.10 (d, J=7.0 Hz, 3H), 3.85-4.00 (m, 4H), 7.30-7.41 (m, 2H), 7.53 (td, J=8.7, 5.8 Hz, 1H), 7.65 (d, J=1.5 Hz, 1H), 7.97 (br.", "s., 1H), 10.14 (br.", "s., 1H).", "Alternative Synthesis of Compound 120: Methyl 1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (6.61 g, 21.03 mmol) and 3-chloro-2,4-difluoroaniline (4.13 g, 25.2 mmol) were dissolved in tetrahydrofuran (150 mL) and this was stirred and cooled in an ice-water bath.", "Over a period of 5 minutes lithium bis(trimethylsilyl)amide in toluene (63.1 mL, 1 M, 63.1 mmol) was added dropwise.", "The resulting mixture was stirred for 1 h while cooling was continued.", "Another 2 eq of lithium bis(trimethylsilyl)amide in toluene (42.1 mL, 1 M, 42.1 mmol) were added and the resulting mixture was stirred for 1 hour at room temperature.", "The resulting mixture was quenched using ammonium chloride (sat./200 mL).", "The resulting mixture was extracted using EtOAc (3×250 mL).", "The combined extracts were washed with brine (250 mL), dried on Na2SO4, filtered and concentrated in vacuo yielding a brown powder.", "This powder was crystallized twice out of methanol/water.", "The precipitation was collected on a glass filter.", "The obtained powder was purified by silica gel column chromatography using gradient elution from heptane to EtOAc (100:0 to 0:100).", "The obtained residue was crystallized again out of methanol/water.", "The white crystals were collected on a glass filter and dried in a vacuum oven at 55° C. for 24 hours yielding compound 120 (3.03 g) as a white powder.", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 217.6° C. Compound 121: N-(3-Chloro-2,4-difluorophenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide 5-[(3-chloro-2,4-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (900 mg, 2.44 mmol) prepared similarly as in the synthesis for compound 57 3-chloro-2,4-difluoro-aniline (3.5 g, 14.46 mmol) was stirred in dry CH3CN (10 mL).", "3-methyloxetan-3-amine (255 mg, 2.93 mmol) was added under N2-atm.", "The reaction mixture was stirred in a sealed tube at room temperature for 18 h. The solvent was evaporated.", "The residue was stirred in CH2Cl2.The formed precipitate was filtered off [fraction 1].", "The filtrate was evaporated and the residue was dissolved in CH2Cl2/MeOH (9/1, 5 mL) and purified by Flash Chromatography [Biotage Isolera 1//GraceResolve Silica 12 g//EtOAc-heptane 0/100 to 100/0].", "The desired fractions were combined and the solvent was evaporated leaving a white solid which was recrystallized in diisopropyl ether/CH3CN (1:1; 6 mL), left stirring for 2 h then left standing for 18 h, filtered off and dried in vacuo at 50° C. yielding white powder which was combined with fraction 1.Method B; Rt: 0.88 min.", "m/z: 418.0 (M−H)− Exact mass: 419.05.1H NMR (400 MHz, DMSO-d6) δ ppm 1.55 (s, 3H), 3.89 (s, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.31-7.38 (m, 2H), 7.53 (td, J=8.7, 5.8 6 Hz, 1H), 7.60 (d, J=1.8 Hz, 1H), 7.98 (br.", "s., 1H), 10.14 (br.", "s., 1H).", "Synthesis of methyl 4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate Chlorosulfonic acid (200 mL, 3.01 mol) was cooled to 0° C. and to this stirring liquid was added methyl 1-methylpyrrole-2-carboxylate (75 g, 538.97 mmol) drop wise.", "After addition the mixture was allowed to reach room temperature.", "Then it was stirred for another hour.", "The resulting mixture was added drop wise to a mechanically stirred, temperature controlled ice-water mixture (2500 mL) keeping the temperature under 5° C. A white precipitation was formed.", "This precipitate was collected on a glass filter and this was washed with cold water (1000 mL).", "The obtained white powder was dried in a vacuum oven at 55° C. for 24 hours yielding methyl 4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate (99 g) as a bright white powder.", "Synthesis of methyl 1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate Methyl 4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate (15 g, 63.11 mmol) was loaded in a pressure tube and this was dissolved in acetonitrile (150 mL).", "To this solution was added diisopropylethylamine (27.2 mL, 157.8 mmol) followed by (R)-1,1,1-trifluoro-2-propylamine (10.7 g, 94.7 mmol).", "The pressure tube was flushed with nitrogen and closed.", "Then it was stirred in a pre-heated oil bath at 80° C. for 6 hours.", "The mixture was cooled to room temperature and concentrated in vacuo.", "The residue was dissolved in dichloromethane (500 mL) and this was washed with HCl (1M/aq/2×250 mL).", "The organics were dried on Na2SO4, filtered and concentrated in vacuo.", "The obtained residue was dried in a vacuum oven at 55° C. for 24 hours yielding methyl 1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate as a yellowish powder (18 g).", "Compound 122: 1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]-N-[3-(trifluoromethyl)phenyl]pyrrole-2-carboxamide Into a 100 mL round bottom flask equipped with a magnetic stir bar was placed methyl 1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (1 g, 3.18 mmol), anhydrous THF (40 mL), and 3-aminobenzotrifluoride (666 mg, 4.14 mmol).", "The vial was sealed and placed into an ice-water bath and to it was added LHMDS (9.6 mL of a 1 M solution in THF) slowly via syringe (approx rate of 2 mL/min).", "Conversion to product seen after 30 min at 0° C. Sat.", "aq.", "ammonium chloride was added to quench the reaction.", "This was diluted with ethyl acetate (100 mL) and the mixture partitioned with ethyl acetate (3×100 mL).", "The organic layers were combined, dried (magnesium sulfate), the solids were removed by filtration and the solvents of the filtrate were removed under reduced pressure.", "The crude was partially purified via silica column chromatography using a dichloromethane to ethylacetate gradient.", "The solvent of the best fractions were removed under reduced pressure and the crude was recrystallized in ethanol/water.", "(1228 mg) Method B; Rt: 1.92 min.", "m/z: 442.0 (M−H)− Exact mass: 443.10.1H NMR (400 MHz, DMSO-d6) δ ppm 1.08 (d, J=7.0 Hz, 3H), 3.86-3.92 (m, 1H), 3.94 (s, 3H), 7.33-7.47 (m, 2H), 7.58 (t, J=8.0 Hz, 1H), 7.66 (d, J=1.8 Hz, 1H), 7.99 (d, J=8.8 Hz, 1H), 8.11-8.24 (m, 2H), 10.34 (s, 1H).", "Compound 123: N-(3-Chloro-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Into a 100 mL round bottom flask, equipped with a magnetic stir bars was placed methyl 1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (1 g, 3.18 mmol), anhydrous THF (40 mL), and 3-chloro-4-fluoro-aniline (602.1 mg, 4.136 mmol).", "The flask was sealed and placed into an ice-water bath and to it was added LHMDS (9.6 mL of a 1M solution in THF/ethylbenzene) slowly via syringe (approx rate of 2 mL/min).", "Conversion to product seen after 30 min at 0° C. Sat.", "aq.", "ammonium chloride was added to quench the reaction.", "This was diluted with ethyl acetate (100 mL) and the mixture partitioned with ethyl acetate (3×100 mL).", "The organic layers were combined, dried (magnesium sulfate), the solids were removed by filtration and the solvents of the filtrate were removed under reduced pressure.", "The crudes were partially purified via silica column chromatography using a dichloromethane to ethylacetate gradient.", "The solvent of the best fractions were removed under reduced pressure.", "The residue was recrystallized from iPrOH (772 mg) Method A; Rt: 1.79 min.", "m/z: 426.0 (M−H)− Exact mass: 427.04.1H NMR (400 MHz, DMSO-d6) δ ppm 1.09 (d, J=7.0 Hz, 3H), 3.85-4.01 (m, 1H), 3.94 (s, 3H), 7.38 (d, J=2.0 Hz, 1H), 7.51 (t, J=9.8 Hz, 1H), 7.66 (d, J=1.8 Hz, 1H), 7.99-8.09 (m, 1H), 8.14-8.24 (m, 2H), 10.36 (s, 1H).", "Compound 124: N-(3-Bromo-4-fluorophenyl)-1-methyl-4-[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl-1H-pyrrole-2-carboxamide Compound 124 (598 mg) was prepared similarly as described for compound 123, using 3-bromo-4-fluoro-aniline instead of 3-chloro-4-fluoro-aniline.", "Method B; Rt: 1.07 min.", "m/z: 472.0 (M−H)− 960 (2M+18) Exact mass: 471.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.08 (d, J=7.0 Hz, 3H), 3.84-3.99 (m, 1H), 3.92 (s, 3H), 7.32-7.41 (m, 2H), 7.64 (d, J=1.8 Hz, 1H), 7.70 (ddd, 6 J=9.0, 4.4, 2.6 Hz, 1H), 8.11-8.20 (m, 2H), 10.21 (s, 1H).", "Compound 125: N-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 125 (664 mg) was prepared similarly as compound 123 using 4-fluoro-3-(trifluoromethyl)aniline (740.9 mg, 4.136 mmol) 3-chloro-4-fluoro-aniline.", "Method B; Rt: 1.96 min.", "m/z: 460.0 (M−H)− 479.2 (M+18) Exact mass: 461.06.1H NMR (400 MHz, DMSO-d6) δ ppm 1.08 (d, J=7.04 Hz, 3H) 3.87-3.98 (m, 1H) 3.93 (s, 3H) 7.40 (t, J=9.13 Hz, 1H) 7.38 (d, J=1.76 Hz, 1H) 7.65 (d, J=1.76 Hz, 1H) 7.68 (ddd, J=9.02, 4.40, 2.64 Hz, 1H) 8.03 (dd, J=6.82, 2.64 Hz, 1H) 8.17 (d, J=8.80 Hz, 1H) 10.28 (s, 1H).", "Compound 126: N-(3-Cyano-4-fluorophenyl)-4-[(2,2-difluoroethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide 4-(chlorosulfonyl)-1-methyl-1H-pyrrole-2-carboxylate (made by the procedure described in the synthesis of 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxylic acid) (5.0 g, 21.0 mmol) was dissolved in acetonitrile (50 mL).", "To this was added diisopropylethylamine (9.06 mL, 52.6 mmol) followed by 2,2-difluoroethylamine (1.93 g, 23.1 mmol) and the resulting mixture was refluxed for 2 hours.", "Then the mixture was cooled to room temperature and concentrated in vacuo.", "The resulting residue was dissolved in dichloromethane (250 mL) and this was washed with aqueous hydrochloric acid (2×150 mL, 1N).", "The organics were dried on sodium sulphate, filtered and concentrated in vacuo yielding methyl 4-(2,2-difluoroethylsulfamoyl)-1-methyl-pyrrole-2-carboxylate (5.4 g) as light brown oil which solidified while standing and was used as such.", "Methyl 4-(2,2-difluoroethylsulfamoyl)-1-methyl-pyrrole-2-carboxylate (5.4 g, 19.1 mmol) was dissolved in tetrahydrofuran (50 mL).", "To this was added an aqueous solution of lithium hydroxide (0.69 g, 28.7 mmol) in distilled water (7 mL) and a turbid mixture was obtained.", "Then methanol (3 mL) was added.", "The resulting mixture was stirred for 24 hours at room temperature and at 60° C. for 1 hour.", "To this was added lithium hydroxide (0.458 g, 19.1 mmol).", "The reaction mixture was further heated at 60° C. for 3 hours.", "Then it was concentrated to keep˜5 mL aqueous solution and extra 15 mL of distilled water was added.", "Then this was neutralized using an exact amount of hydrochloric acid (47.8 mL, 47.83 mmol/1M/aq/).", "The resulting mixture was extracted using methyltetrahydrofuran (3×20 mL).", "The combined extracts were dried on sodium sulphate, filtered and concentrated in vacuo yielding of 4-(2,2-difluoroethylsulfamoyl)-1-methyl-pyrrole-2-carboxylic acid (4.88 g) as white powder which was used as such.", "1H NMR (400 MHz, DMSO-d6) δ ppm 3.15 (tdd, J=15.4, 15.4, 6.4, 4.0 Hz, 2H), 3.88 (s, 3H), 5.99 (tt, J=55.7, 4.2 Hz, 1H), 6.98 (d, J=2.0 Hz, 1H), 7.61 (d, J=2.0 Hz, 1H), 7.84 (t, J=6.4 Hz, 1H).", "4-(2,2-difluoroethylsulfamoyl)-1-methyl-pyrrole-2-carboxylic acid (500 mg, 1.77 mmol) and 5-amino-2-fluorobenzonitrile (0.5 g, 3.54 mmol) and HATU (0.81 g, 2.12 mmol) were dissolved in DMF (2.5 mL) containing diisopropylethylamine (1.22 mL, 7.08 mmol).", "The reaction mixture was stirred at room temperature for 66 hours.", "The reaction mixture was directly loaded on column and purified using silica gel column chromatography (ethyl acetate in heptane from 20 to 80%).", "The desired fractions were combined and evaporated to keep ˜50 mL of the solvent and 20 mL of diethyl ether was added.", "The formed precipitate was filtered and washed with diethyl ether to afford compound 126 (412 mg) as white solid.", "Method B; Rt: 0.88 min.", "m/z: 385 (M−H)− Exact mass: 386.07.1H NMR (400 MHz, DMSO-d6) δ ppm 3.20 (td, J=15.3, 4.0 Hz, 2H), 3.92 (s, 3H), 6.02 (tt, J=55.7, 4.0 Hz, 1H), 7.37 (d, J=2.0 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.65 (d, J=1.5 Hz, 1H), 7.93 (br.", "s, 1H), 8.01 (ddd, J=9.2, 5.0, 2.8 Hz, 1H), 8.21 (dd, J=5.7, 2.6 Hz, 1H), 10.36 (br.", "s., 1H).", "Compound 127: N-(3-Bromo-4-fluorophenyl)-4-[(2,2-difluoroethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide Compound 127 (452 mg) as white powder was synthesized similarly as described for compound 126 using 3-bromo-4-fluoroaniline instead of 5-amino-2-fluorobenzonitrile in the last step.", "Method B; Rt: 1.00 min.", "m/z: 438 (M−H)− Exact mass: 438.98.1H NMR (400 MHz, DMSO-d6) δ ppm 3.20 (td, J=15.3, 4.0 Hz, 2H), 3.92 (s, 3H), 6.02 (tt, J=55.5, 4.0 Hz, 1H), 7.34-7.39 (m, 2H), 7.63 (d, J=1.5 Hz, 1H), 7.70 (ddd, J=9.0, 4.4, 2.6 Hz, 1H), 7.88 (br.", "s., 1H), 8.14 (dd, J=6.5, 2.5 Hz, 1H), 10.21 (br.", "s., 1H).", "Compound 128: N-(3-Chloro-4-fluorophenyl)-4-[(2,2-difluoroethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide Compound 128 (372 mg) as white powder was synthesized similarly as described for compound 126 using 3-chloro-4-fluoroaniline instead of 5-amino-2-fluorobenzonitrile in the last step.", "Method B; Rt: 0.99 min.", "m/z: 394 (M−H)− Exact mass: 395.03.1H NMR (400 MHz, DMSO-d6) δ ppm 3.20 (td, J=15.3, 4.0 Hz, 2H), 3.92 (s, 3H), 6.02 (tt, J=55.7, 4.0 Hz, 1H), 7.35 (d, J=1.8 Hz, 1H), 7.40 (t, J=9.1 Hz, 1H), 7.61-7.69 (m, 2H), 7.89 (br.", "s., 1H), 8.02 (dd, J=6.9, 2.5 Hz, 1H), 10.22 (br.", "s., 1H).", "Compound 129: 4-[(2,2-Difluoroethyl)sulfamoyl]-N-(3,4-difluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide Compound 129 (371 mg) as white powder was synthesized similarly as described for compound 126 using 3,4-difluoroaniline instead of 5-amino-2-fluorobenzonitrile in the last step.", "Method B; Rt: 0.94 min.", "m/z: 378 (M−H)− Exact mass: 379.06.1H NMR (400 MHz, DMSO-d6) δ ppm 3.20 (td, J=15.2, 4.1 Hz, 2H), 3.92 (s, 3H), 6.02 (tt, J=55.5, 4.0 Hz, 1H), 7.34 (d, J=2.0 Hz, 1H), 7.41 (dt, J=10.3, 9.0 Hz, 1H), 7.46-7.53 (m, 1H), 7.64 (d, J=1.8 Hz, 1H), 7.79-7.94 (m, 2H), 10.24 (br.", "s., 1H).", "Compound 130: N-(3-Chloro-4,5-difluorophenyl)-4-[(2,2-difluoroethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide Compound 130 was synthesized similarly as described for compound 126.In the last step, 3-chloro-4,5-difluoroaniline hydrochloride (synthesis described in synthesis for compound 57) instead of 5-amino-2-fluorobenzonitrile was used and the reaction time was 18 hours instead of 66 hours.", "The reaction mixture was purified using silica gel column chromatography (gradient elution: ethyl acetate in heptane from 0 to 100% and from 30 to 50%).", "The purest fractions were combined and stored as such for 66 hours.", "White precipitates were filtered and washed with heptane to afford a white solid.", "The solids were dissolved in methanol and concentrated to dryness to afford a white powder which was warm triturated in methanol (3 mL) and cooled to room temperature.", "The white solids were filtered and washed with methanol to afford compound 130 (131 mg) as white powder.", "Method B; Rt: 0.94 min.", "m/z: 412 (M−H)− Exact mass: 413.02.1H NMR (400 MHz, DMSO-d6) δ ppm 3.20 (td, J=15.3, 4.0 Hz, 2H), 3.91 (s, 3H), 6.02 (tt, J=55.7, 4.0 Hz, 1H), 7.35 (d, J=2.0 Hz, 1H), 7.49-8.27 (m, 4H), 10.31 (br.", "s., 1H).", "Compound 131: N-(3-Chloro-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoroethyl)sulfamoyl]-1H-pyrrole-2-carboxamide 4-(chlorosulfonyl)-1-methyl-1H-pyrrole-2-carboxylate (made by the procedure described in the synthesis of 1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxylic acid) (5.0 g, 21.0 mmol) was dissolved in acetonitrile (50 mL).", "To this was added DIPEA (9.06 mL, 52.6 mmol) followed by 2,2,2-trifluoroethylamine (2.29 g, 23.1 mmol) and the resulting mixture was refluxed for 2 hours.", "Then the mixture was cooled to room temperature and concentrated in vacuo.", "The resulting residue was dissolved in dichloromethane (250 mL) and this was washed with aqueous hydrochloric acid (2×150 mL, 1N).", "The organics were dried on sodium sulphate, filtered and concentrated in vacuo yielding methyl 1-methyl-4-(2,2,2-trifluoroethyl-sulfamoyl)pyrrole-2-carboxylate (5.3 g) as light brown oil which solidified while standing and was used as such.", "Methyl 1-methyl-4-(2,2,2-trifluoroethylsulfamoyl)pyrrole-2-carboxylate (5.3 g, 17.65 mmol) was dissolved in tetrahydrofuran (50 mL) and a solution of lithium hydroxide (0.634 g, 26.5 mmol) in distilled water (7 mL) was added and a turbid mixture was obtained.", "Then methanol (3 mL) was added and the mixture became clear.", "The resulting mixture was stirred at room temperature for 24 hours and at 60° C. for 1 hour.", "To this was added lithium hydroxide (0.423 g, 17.7 mmol).", "The reaction mixture was further heated at 60° C. for 3 hours.", "Then the reaction mixture was concentrated to keep ˜5 mL and distilled water (15 mL) was added.", "The mixture was neutralized using an exact amount of hydrochloric acid (1M/aq/31.6 mL, 31.58 mmol).", "The resulting mixture was extracted using methyltetrahydrofuran (3×20 mL).", "The combined extracts were dried on sodium sulphate, filtered and concentrated in vacuo yielding 1-methyl-4-(2,2,2-trifluoroethylsulfamoyl)pyrrole-2-carboxylic acid (4.62 g) as beige powder which was used as such.", "1-methyl-4-(2,2,2-trifluoroethylsulfamoyl)pyrrole-2-carboxylic acid (500 mg, 1.66 mmol) and 3-chloro-4-fluoroaniline (0.48 g, 3.32 mmol) and HATU (0.76 g, 1.99 mmol) were dissolved in DMF (2 mL) containing diisopropylethylamine (1.14 mL, 6.64 mmol).", "The reaction mixture was stirred at room temperature for 66 hours.", "The reaction mixture was directly loaded on column and purified using silica gel column chromatography (ethyl acetate in heptane from 20 to 80%).", "The desired fractions were combined and evaporated to keep ˜50 mL of the solvent and 20 mL of diethyl ether was added.", "The formed precipitate was filtered and washed with diethyl ether to afford an off white solid which was recrystallized from acetonitrile (5 mL) to afford compound 131 (117 mg) as white solid.", "Method B; Rt: 1.03 min.", "m/z: 412 (M−H)− 431 (M+18) Exact mass: 413.02 1H NMR (400 MHz, DMSO-d6) δ ppm 3.62 (q, J=9.5 Hz, 2H), 3.91 (s, 3H), 7.31-7.45 (m, 2H), 7.61-7.70 (m, 2H), 8.02 (dd, J=6.8, 2.6 Hz, 1H), 8.27 (br.", "s., 1H), 10.23 (br.", "s, 1H).", "Compound 132: N-(3,4-Difluorophenyl)-1-methyl-4-[(2,2,2-trifluoroethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 132 was synthesized similarly as described for compound 131 using 3,4-difluoroaniline (433 mg, 3.32 mmol) instead of 3-chloro-4-fluoroaniline in the last step.", "The off white solid was recrystallized from methanol to afford compound 132 (208 mg) as white powder.", "Method B; Rt: 0.98 min.", "m/z: 396 (M−H)− Exact mass: 397.05.1H NMR (400 MHz, DMSO-d6) δ ppm 3.62 (q, J=9.6 Hz, 2H), 3.91 (s, 3H), 7.35 (d, J=1.8 Hz, 1H), 7.41 (dt, J=10.5, 9.1 Hz, 1H), 7.45-7.52 (m, 1H), 7.65 (d, J=1.8 Hz, 1H), 7.87 (ddd, J=13.4, 7.5, 2.4 Hz, 1H), 8.26 (br.", "s., 1H), 10.24 (s, 1H).", "Compound 133: N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-[(2,2,2-trifluoroethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 133 was synthesized similarly as described for compound 131.3-chloro-4,5-difluoroaniline hydrochloride (664 mg, 332 mmol) (synthesis described in synthesis for compound 57) was used instead of 3-chloro-4-fluoroaniline in the last step.", "The reaction mixture was directly loaded on column and purified using silica gel column chromatography (ethyl acetate in heptane from 0 to 100%) The purest fractions were combined and stored as such for 66 hours.", "Off white crystals were formed and filtered and washed with heptane to afford a beige solid.", "The solid was triturated in diethyl ether (15 mL) and filtered and washed with diethyl ether to afford a white powder.", "The white powder was purified using silica gel column chromatography (methanol in CH2Cl2 from 0 to 2%) The purest fractions were combined and concentrated to dryness to afford compound 133 (41 mg) as white powder.", "Method B; Rt: 1.09 min.", "m/z: 430 (M−H)− 863 (2M+H) Exact mass: 431.01.1H NMR (400 MHz, DMSO-d6) δ ppm 3.62 (q, J=9.6 Hz, 2H), 3.91 (s, 3H), 7.36 (d, J=1.8 Hz, 1H), 7.67 (d, J=1.8 Hz, 1H), 7.77-7.85 (m, 2H), 8.29 (br.", "s., 1H), 10.32 (br.", "s., 1H).", "Compound 134: N-(3-Cyano-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoroethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 134 was synthesized similarly as described for compound 131 using 5-amino-2-fluorobenzonitrile (466 mg, 3.32 mmol) instead of 3-chloro-4-fluoroaniline in the last step.", "The reaction mixture was directly loaded on column and purified using silica gel column chromatography (ethyl acetate in heptane from 20 to 80%).", "The desired fractions were combined and evaporated to keep ˜50 mL of the solvent and 20 mL of diethyl ether was added.", "The formed precipitate was filtered and washed with diethyl ether to afford an off white solid which was purified using Prep.", "LCMS.", "(Hypersyl C18 BDS-3 μm, 100×4.6 mm) Mobile phase (NH4HCO3 0.2% in water, acetonitrile) the desired fractions were combined and evaporated to dryness, dissolved in methanol again and evaporated to dryness and dried in vacuum oven overnight to afford compound 134 (147 mg) as white powder.", "Method B; Rt: 0.93 min.", "m/z: 403 (M−H)− Exact mass: 404.06.1H NMR (400 MHz, DMSO-d6) δ ppm 3.61 (q, J=9.5 Hz, 2H), 3.92 (s, 3H), 7.37 (d, J=2.0 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.66 (d, J=1.5 Hz, 1H), 8.00 (ddd, J=9.2, 4.9, 2.9 Hz, 1H), 8.33 (br.", "s, 1H), 8.22 (dd, J=5.9, 2.6 Hz, 1H), 10.38 (br.", "s., 1H).", "Compound 135: N-(3-Bromo-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoroethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 135 was synthesized similarly as described for compound 134 using 3-bromo-4-fluoroaniline (631 mg, 3.32 mmol) instead of 5-amino-2-fluorobenzonitrile in the last step.", "Method B; Rt: 1.04 min.", "m/z: 456 (M−H)− Exact mass: 456.97.1H NMR (400 MHz, DMSO-d6) δ ppm 3.62 (q, J=9.5 Hz, 2H), 3.91 (s, 3H), 7.34-7.40 (m, 2H), 7.65 (d, J=1.8 Hz, 1H), 7.70 (ddd, J=9.1, 4.3, 2.4 Hz, 1H), 8.14 (dd, J=6.4, 2.6 Hz, 1H), 8.26 (br.", "s., 1H), 10.21 (br.", "s, 1H).", "Compound 136: N-(3-Chloro-4,5-difluorophenyl)-1,5-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Crude ethyl 1,5-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylate (described in synthesis of compound 89)(1800 mg, 5.689 mmol) was dissolved in methanol (8 mL), lithium hydroxide (720 mg, 30.1 mmol) in water (2 mL) was added and the reaction mixture was heated at 50° C. for 2 hours.", "The reaction mixture was evaporated to dryness and co evaporated with toluene (2×50 mL) to afford a beige powder.", "Half of the above obtained powder was dissolved in water (5 mL), and HCl (1M in water, 15.02 mL) was added.", "The water layer was extracted with Me-THF (3×20 mL).", "The combined organic layers were washed with Brine, dried (Na2SO4) and concentrated to dryness to afford 1,5-dimethyl-4-(N-(3-methyloxetan-3-yl)sulfamoyl)-1H-pyrrole-2-carboxylic acid (600 mg).", "1,5-dimethyl-4-(N-(3-methyloxetan-3-yl)-sulfamoyl)-1H-pyrrole-2-carboxylic acid (600 mg, 2.08 mmol) was dissolved in DMF (3 mL).", "diisopropylethylamine (1.08 mL, 6.24 mmol), HATU (950 mg, 2.50 mmol), and 3-chloro-4,5-difluoroaniline hydrochloride (described in the synthesis of compound 57) were added and the reaction mixture was stirred at room temperature for 68 hours and at 60° C. for 2 hours.", "The reaction mixture was directly loaded on column.", "The reaction mixture was purified using silica gel column chromatography (ethyl acetate in heptane from 20 to 80%).", "The desired fraction were combined and concentrated to keep ˜100 mL of solvent.", "The white precipitate was filtered and washed with petroleum ether and dried in vacuum oven overnight to afford compound 136 (604 mg) as white powder.", "Method B; Rt: 1.03 min.", "m/z: 432 (M−H)− Exact mass: 433.07.1H NMR (400 MHz, DMSO-d6) δ ppm 1.49 (s, 3H), 2.44 (s, 3H), 3.83 (s, 3H), 4.11 (d, J=6.4 Hz, 2H), 4.59 (d, J=5.9 Hz, 2H), 7.35 (s, 1H), 7.77-7.86 (m, 2H), 7.97 (s, 1H), 10.20 (s, 1H).", "Compound 137: N-(3-Chloro-4,5-difluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide In a pressure tube, crude ethyl 4-chlorosulfonyl-1,5-dimethyl-pyrrole-2-carboxylate (3.03 g, 11.4 mmol) (synthesis described in synthesis for compound 89) was dissolved in acetonitrile (30 mL).", "To this was added diisopropylethylamine (4.91 mL, 28.5 mmol) followed by (R)-1,1,1-trifluoro-2-propylamine (3.22 g, 28.5 mmol) and the tube was closed and resulting mixture was heated at 80° C. for 2 hours.", "The reaction mixture was concentrated and the resulting orange sticky oil was dissolved in dichloromethane (50 mL) and this was washed with aqueous hydrochloric acid (1N, 2×20 mL).", "The organics were dried on sodium sulphate, filtered and concentrated in vacuo yielding orange oil (3.41 g) which was purified using silica gel column chromatography (ethyl acetate in heptane from 0 to 80%).", "The desired fractions were combined and evaporated to dryness to afford (R)-ethyl 1,5-dimethyl-4-(N-(1,1,1-trifluoropropan-2-yl)sulfamoyl)-1H-pyrrole-2-carboxylate (2.3 g) as white powder which was used as such.", "(R)-ethyl 1,5-dimethyl-4-(N-(1,1,1-trifluoropropan-2-yl)sulfamoyl)-1H-pyrrole-2-carboxylate (2.3 g, 6.72 mmol) was dissolved in ethanol (30 mL) and sodium hydroxide in water (13.4 mL, 13.4 mmol, 1 M) was added and the reaction mixture was stirred at 40° C. for 2 hours and at room temperature for 66 hours.", "The reaction mixture was heated at 70° C. for 2 hours.", "Sodium hydroxide in water (6.72 mL, 6.72-mmol, 1 M) was added to the reaction mixture which was heated at 70° C. for 2 hours more.", "The reaction mixture was allowed to reach room temperature and was concentrated to keep ˜20 mL.", "HCl (20.15 mL, 20.15 mmol, 1M) was added.", "The water layer was extracted with Me-THF (3×20 mL).", "The combined organic layers were washed with Brine, dried (Na2SO4) and concentrated to dryness to afford (R)-1,5-dimethyl-4-(N-(1,1,1-trifluoropropan-2-yl)sulfamoyl)-1H-pyrrole-2-carboxylic acid (2.05 g).", "(R)-1,5-dimethyl-4-(N-(1,1,1-trifluoropropan-2-yl)sulfamoyl)-1H-pyrrole-2-carboxylic acid (450 mg, 1.43 mmol) and 3-chloro-4,5-difluoroaniline hydrochloride (0.57 g, 2.86 mmol) (synthesis described in synthesis for compound 57) and HATU (0.73 g, 1.91 mmol) were dissolved in DMF (2 mL) containing diisopropylethylamine (0.82 mL, 4.77 mmol).", "The reaction mixture was stirred at 40° C. for 66 hours.", "The reaction mixture was directly loaded on column.", "The reaction mixture was purified using silica gel column chromatography (ethyl acetate in heptane from 20 to 80%).", "The desired fractions were combined and evaporated to keep ˜50 mL of solvent.", "The precipitates were filtered and washed with petroleum ether and dried in vacuum oven at 50° C. overnight to afford compound 137 (490 mg) as white powder.", "Method B; Rt: 1.16 min.", "m/z: 458 (M−H)− 460 (M+H)+ Exact mass: 459.04.1H NMR (400 MHz, DMSO-d6) δ ppm 1.07 (d, J=6.8 Hz, 3H), 2.44 (s, 3H), 3.69-3.95 (m, 4H), 7.37 (s, 1H), 7.76-7.86 (m, 2H), 8.21 (br.", "s., 1H), 10.24 (br.", "s., 1H).", "Compound 138: N-(3-Chloro-4-fluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 138 (510 mg) as white powder was synthesized similarly as described for compound 137 using 3-chloro-4-fluoroaniline instead of 3-chloro-4,5-difluoroaniline hydrochloride in the last step.", "Method B; Rt: 1.10 min.", "m/z: 440 (M−H)− Exact mass: 441.05.1H NMR (400 MHz, DMSO-d6) δ ppm 1.07 (d, J=7.0 Hz, 3H), 2.44 (s, 3H), 3.75-3.87 (m, 4H), 7.36 (s, 1H), 7.39 (t, J=9.1 Hz, 1H), 7.66 (ddd, J=9.1, 4.3, 2.6 Hz, 1H), 8.02 (dd, J=6.9, 2.5 Hz, 1H), 8.19 (br.", "s, 1H), 10.15 (s, 1H).", "Compound 139: N-(3,4-Difluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 139 (462 mg) as white powder was synthesized similarly as described for compound 137 using 3,4-difluoroaniline instead of 3-chloro-4,5-difluoroaniline hydrochloride in the last step.", "Method B; Rt: 1.06 min.", "m/z: 424 (M−H)− 426 (M+H)+ Exact mass: 425.08.1H NMR (400 MHz, DMSO-d6) δ ppm 1.07 (d, J=6.8 Hz, 3H), 2.44 (s, 3H), 3.75-3.88 (m, 4H), 7.35 (s, 1H), 7.40 (dt, J=10.5, 9.2 Hz, 1H), 7.45-7.54 (m, 1H), 7.87 (ddd, J=13.4, 7.6, 2.5 Hz, 1H), 8.19 (br.", "s., 1H), 10.17 (s, 1H).", "Compound 140: N-(3-Cyano-4-fluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide (R)-1,5-dimethyl-4-(N-(1,1,1-trifluoropropan-2-yl)sulfamoyl)-1H-pyrrole-2-carboxylic acid (168 mg, 0.53 mmol) (synthesis described in synthesis for compound 137) 5-amino-2-fluorobenzonitrile (0.15 g, 1.07 mmol) and HATU (0.24 g, 0.64 mmol) were dissolved in DMF (1 mL) containing diisopropylethylamine (0.23 mL, 1.34 mmol).", "The reaction mixture was stirred at 50° C. for 1 hour.", "The reaction mixture was purified using silica gel column chromatography (ethyl acetate in heptane from 20 to 80%).", "The desired fractions were combined and evaporated to keep ˜50 mL of the solvent.", "The white solids were filtered and dried in vacuum oven to afford compound 140 (180 mg) as white powder.", "Method B; Rt: 1.00 min.", "m/z: 431 (M−H)− Exact mass: 432.09.1H NMR (400 MHz, DMSO-d6) δ ppm 1.07 (d, J=6.8 Hz, 3H), 2.44 (s, 3H), 3.76-3.87 (m, 1H), 3.84 (s, 3H), 7.38 (s, 1H), 7.52 (t, J=9.1 Hz, 1H), 8.01 (ddd, J=9.2, 4.8, 2.9 Hz, 1H), 8.10-8.35 (m, 1H), 8.22 (dd, J=5.9, 2.6 Hz, 1H), 10.30 (br.", "s, 1H).", "Compound 141: N-(3-Bromo-4-fluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 141 (210 mg) as white powder was synthesized similarly as described for compound 140 using 3-bromo-4-fluoroaniline (0.20 g, 1.07 mmol) instead of 5-amino-2-fluorobenzonitrile.", "Method B; Rt: 1.11 min.", "m/z: 484 (M−H)− Exact mass: 485.00.1H NMR (400 MHz, DMSO-d6) δ ppm 1.07 (d, J=7.0 Hz, 3H), 2.43 (s, 3H), 3.74-3.89 (m, 1H), 3.83 (s, 3H), 7.29-7.40 (m, 2H), 7.70 (ddd, J=9.0, 4.4, 2.6 Hz, 1H), 8.13 (dd, J=6.4, 2.6 Hz, 1H), 8.18 (br.", "s., 1H), 10.13 (s, 1H).", "Compound 142: N-[4-Fluoro-3-(trifluoromethyl)phenyl]-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 142 (187 mg) as white powder was synthesized similarly as described for compound 140 using 4-fluoro-3-(trifluoromethyl)aniline (0.19 g, 1.07 mmol) instead of 5-amino-2-fluorobenzonitrile.", "Method B; Rt: 1.14 min.", "m/z: 474 (M−H)− Exact mass: 475.08.1H NMR (400 MHz, DMSO-d6) δ ppm 1.07 (d, J=7.0 Hz, 3H), 2.44 (s, 3H), 3.76-3.85 (m, 1H), 3.84 (s, 3H), 7.39 (s, 1H), 7.49 (br.", "t, J=9.8, 9.8 Hz, 1H), 8.00-8.08 (m, 1H), 8.10-8.30 (m, 1H), 8.19 (dd, J=6.6, 2.6 Hz, 1H), 10.28 (s, 1H).", "Compound 143: N-(3-Chloro-2,4-difluorophenyl)-1,5-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 143 (147 mg) as white powder was synthesized similarly as described for compound 140 using 3-chloro-2,4-difluoroaniline (0.17 g, 1.07 mmol) instead of 5-amino-2-fluorobenzonitrile.", "The reaction mixture was stirred at 60° C. for 2 hours more.", "Method B; Rt: 1.07 min.", "m/z: 458 (M−H)− Exact mass: 459.04.1H NMR (400 MHz, DMSO-d6) δ ppm 1.09 (d, J=7.0 Hz, 3H), 2.44 (s, 3H), 3.82 (s, 3H), 3.76-3.91 (m, 1H), 7.34 (td, J=9.0, 2.0 Hz, 1H), 7.35 (s, 1H), 7.52 (td, J=8.7, 5.8 Hz, 1H), 8.20 (br.", "s., 1H), 10.05 (s, 1H).", "Synthesis of ethyl 4-chlorosulfonyl-1,3-dimethyl-pyrrole-2-carboxylate (step 1) Ethyl 1, 3-dimethylpyrrole-2-carboxylate (10.7 g, 61.0 mmol) was added drop wise to chlorosulfonic acid (33.3 mL, 500 mmol) at 0° C. under nitrogen atmosphere.", "The reaction mixture was warmed to room temperature and allowed to stir 2 hours.", "The resulting mixture was added drop wise to a stirred, temperature controlled ice-water mixture (200 mL) keeping the temperature under 5° C. A white precipitation was formed.", "The obtained aqueous suspension was extracted using dichloromethane (3×100 mL).", "The combined extracts were washed with Brine and dried on sodium sulphate, filtered and concentrated in vacuo yielding ethyl 4-chlorosulfonyl-1,3-dimethyl-pyrrole-2-carboxylate (13.96 g) as a brown powder which was used as such.", "Method B; Rt: 1.11 min.", "m/z: 264 (M−H)− Exact mass: 265.02.Synthesis of Ethyl 1,3-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (step 2) In a pressure tube, ethyl 4-chlorosulfonyl-1,3-dimethyl-pyrrole-2-carboxylate (4.65 g, 17.5 mmol) was dissolved in acetonitrile (30 mL).", "To this was added diisopropylethylamine (7.54 mL, 43.8 mmol) followed by (R)-1,1,1-trifluoro-2-propylamine (2.97 g, 26.3 mmol) and the tube was closed and resulting mixture was heated at 80° C. overnight.", "Then the mixture was cooled to room temperature and concentrated.", "The resulting brown sticky oil was dissolved in dichloromethane (100 mL) and this was washed with hydrochloric acid (1N, 2×30 mL).", "The organics were dried on sodium sulphate, filtered and concentrated in vacuo yielding brown oil (5.12 g).", "The brown oil was purified using silica gel column chromatography (gradient elution: ethyl acetate: heptane from 0 to 80%).", "The desired fractions were combined and evaporated to dryness to afford ethyl 1,3-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (3.05 g) as light yellow powder.", "Method B; Rt: 0.96 min.", "m/z: 341 (M−H)− Exact mass: 342.09.Synthesis of 1,3-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid (Step 3) Ethyl 1,3-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (3.05 g, 8.46 mmol) was dissolved in ethanol (50 mL) and sodium hydroxide in water (1 M, 42.3 mL, 42.3 mmol) was added.", "The reaction mixture was stirred at 80° C. for 18 hours.", "The reaction mixture was allowed to reach room temperature and was concentrated to keep ˜20 mL solvent.", "The solution was diluted with aqueous hydrochloride (1 M, 42.3 mL, 42.3 mmol) and extracted with Me-THF (3×30 mL).", "The combined organic layers were washed with Brine, dried (Na2SO4) and concentrated to dryness to afford 1,3-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid (2.71 g).", "Method B; Rt: 0.45 min.", "m/z: 313 (M−H)− Exact mass: 314.05.Compound 144: N-(3,4-Difluorophenyl)-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide (step 4) 1,3-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid (450 mg, 1.43 mmol) and 3,4-difluoroaniline (0.37 g, 2.86 mmol) and HATU (0.73 g, 1.91 mmol) were dissolved in DMF (1.92 mL, 24.7 mmol) containing diisopropylethylamine (0.82 mL, 4.77 mmol).", "The reaction mixture was stirred at 40° C. for 42 hours and allowed to reach room temperature.", "The reaction mixtures were purified using silica gel column chromatography (gradient elution: ethyl acetate in heptane from 10 to 70%).", "The desired fractions were combined and evaporated to keep ˜50 mL of the solvent.", "The white solids were filtered and dried overnight in vacuum oven at 50° C. to afford compound 144 (470 mg) as white powder.", "Method B; Rt: 1.01 min.", "m/z: 424 (M−H)− Exact mass: 425.08.1H NMR (400 MHz, DMSO-d6) δ ppm 1.11 (d, J=6.8 Hz, 3H), 2.29 (s, 3H), 3.72 (s, 3H), 3.82 (quin, J=7.5 Hz, 1H), 7.37-7.46 (m, 2H), 7.50 (s, 1H), 7.73-7.92 (m, 1H), 8.16 (br.", "s., 1H), 10.31 (s, 1H).", "Compound 145: N-(3-Chloro-4-fluorophenyl)-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 145 (452 mg) as white powder was synthesized similarly as described for compound 144 using 3-chloro-4-fluoroaniline instead of 3,4-difluoroaniline.", "Method B; Rt: 1.06 min.", "m/z: 440 (M−H)− Exact mass: 441.05.1H NMR (400 MHz, DMSO-d6) δ ppm 1.11 (d, J=6.8 Hz, 3H), 2.30 (s, 3H), 3.72 (s, 3H), 3.83 (quin, J=6.6 Hz, 1H), 7.41 (t, J=9.1 Hz, 1H), 7.50 (s, 1H), 7.55-7.71 (m, 1H), 7.98 (dd, J=6.7, 2.1 Hz, 1H), 8.16 (br.", "s., 1H), 10.29 (s, 1H).", "Compound 146: N-(3,4-Difluorophenyl)-1,3-dimethyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 146 (353 mg) as white powder was synthesized similarly as described for compound 144 using (S)-1,1,1-trifluoro-2-propylamine (1.50 g, 13.3 mmol) instead of (R)-1,1,1-trifluoro-2-propylamine in Step 2 (resulting in 1,3-dimethyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid as intermediate).", "Method B; Rt: 1.01 min.", "m/z: 424 (M−H)− Exact mass: 425.08.1H NMR (400 MHz, DMSO-d6) δ ppm 1.11 (d, J=6.8 Hz, 3H), 2.29 (s, 3H), 3.72 (s, 3H), 3.76-3.87 (m, 1H), 7.34-7.46 (m, 2H), 7.49 (s, 1H), 7.74-7.91 (m, 1H), 8.16 (br.", "s., 1H), 10.31 (s, 1H).", "Compound 147: N-(3-Chloro-4-fluorophenyl)-1,3-dimethyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 147 (443 mg) as white powder was synthesized similarly as described for compound 144 using (S)-1,1,1-trifluoro-2-propylamine (1.50 g, 13.3 mmol) instead of (R)-1,1,1-trifluoro-2-propylamine in Step 2 (resulting in 1,3-dimethyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid as intermediate) and 3-chloro-4-fluoroaniline instead of 3,4-difluoroaniline in Step 4.Method B; Rt: 1.06 min.", "m/z: 440 (M−H)− Exact mass: 441.05.1H NMR (400 MHz, DMSO-d6) δ ppm 1.11 (d, J=7.0 Hz, 3H), 2.30 (s, 3H), 3.72 (s, 3H), 3.83 (quin, J=7.2 Hz, 1H), 7.41 (t, J=9.1 Hz, 1H), 7.50 (s, 1H), 7.62 (ddd, J=9.0, 4.2, 2.6 Hz, 1H), 7.98 (dd, J=6.8, 2.4 Hz, 1H), 8.17 (br.", "s., 1H), 10.29 (s, 1H).", "Compound 148: N-(3,4-Difluorophenyl)-1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 148 was synthesized similarly as described for compound 144 using 3-methyl-3-oxetanamine instead of (R)-1,1,1-trifluoro-2-propylamine in Step 2.In Step 4, the desired fractions were evaporated to afford oil which was purified again using silica gel column chromatography (gradient elution: ethyl acetate in heptane from 40 to 70%).", "The desired fractions were combined and evaporated to afford compound 148 (475 mg) as white powder.", "Method B; Rt: 0.86 min.", "m/z: 398 (M−H)− Exact mass: 399.11.1H NMR (400 MHz, DMSO-d6) δ ppm 1.53 (s, 3H), 2.32 (s, 3H), 3.72 (s, 3H), 4.13 (d, J=6.4 Hz, 2H), 4.62 (d, J=5.9 Hz, 2H), 7.36-7.51 (m, 3H), 7.62-8.16 (m, 2H), 10.32 (br.", "s., 1H).", "Compound 149: N-(3-Chloro-4-fluorophenyl)-1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 149 was synthesized as compound 144 using 3-methyl-3-oxetanamine instead of (R)-1,1,1-trifluoro-2-propylamine in Step 2 and 3-chloro-4-fluoroaniline instead of 3,4-difluoroaniline in Step 4.In Step 4, the desired fractions were evaporated to afford oil which solidified while standing.", "The powder was triturated in warm CH2Cl2 (10 mL) and allowed to reach room temperature.", "The white solids were filtered and washed with CH2Cl2 (5 mL) and petroleum ether (5 mL) and dried in vacuum oven at 50° C. to afford compound 149 (435 mg) as white powder.", "Method B; Rt: 0.92 min.", "m/z: 414 (M−H)− Exact mass: 415.08.1H NMR (400 MHz, DMSO-d6) δ ppm 1.53 (s, 3H), 2.32 (s, 3H), 3.72 (s, 3H), 4.12 (d, J=6.4 Hz, 2H), 4.62 (d, J=5.9 Hz, 2H), 7.41 (t, J=9.1 Hz, 1H), 7.47 (s, 1H), 7.62 (ddd, J=9.0, 4.4, 2.6 Hz, 1H), 7.91 (br.", "s., 1H), 7.99 (dd, J=6.8, 2.6 Hz, 1H), 10.29 (br.", "s., 1H).", "Compound 150: N-(3-Cyano-4-fluorophenyl)-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 150 (416 mg) as white powder was synthesized as compound 144 using 5-amino-2-fluorobenzonitrile instead of 3,4-difluoroaniline and the reaction time was 20 hours instead of 42 hours in Step 4.Method C; Rt: 1.68 min.", "m/z: 431 (M−H)− Exact mass: 432.09.1H NMR (400 MHz, DMSO-d6) δ ppm 1.11 (d, J=7.0 Hz, 3H), 2.31 (s, 3H), 3.73 (s, 3H), 3.83 (quin, J=7.2 Hz, 1H), 7.52 (br.", "s, 1H), 7.54 (t, J=9.1 Hz, 1H), 7.97 (ddd, J=9.2, 4.9, 2.6 Hz, 1H), 8.09-8.27 (m, 1H), 8.18 (dd, J=5.7, 2.6 Hz, 1H), 10.42 (br.", "s., 1H).", "Compound 151: N-(3-Cyano-4-fluorophenyl)-1,3-dimethyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 151 (420 mg) as white powder was synthesized similarly as described for compound 144 using (S)-1,1,1-trifluoro-2-propylamine (1.50 g, 13.3 mmol) instead of (R)-1,1,1-trifluoro-2-propylamine in Step 2 and 5-amino-2-fluorobenzonitrile instead of 3,4-difluoroaniline and the reaction time was 20 hours instead of 42 hours in Step 4.Method B; Rt: 0.96 min.", "m/z: 431 (M−H)− Exact mass: 432.09.1H NMR (400 MHz, DMSO-d6) δ ppm 1.11 (d, J=6.8 Hz, 3H), 2.31 (s, 3H), 3.73 (s, 3H), 3.83 (quin, J=7.2 Hz, 1H), 7.51 (s, 1H), 7.54 (t, J=9.2 Hz, 1H), 7.97 (ddd, J=9.2, 4.9, 2.9 Hz, 1H), 8.09-8.27 (m, 1H), 8.18 (dd, J=5.9, 2.6 Hz, 1H), 10.42 (br.", "s., 1H).", "Compound 152: N-(3-Cyano-4-fluorophenyl)-1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 152 was synthesized similarly as described for compound 144 using 3-methyl-3-oxetanamine instead of (R)-1,1,1-trifluoro-2-propylamine in Step 2 and 5-amino-2-fluorobenzonitrile instead of 3,4-difluoroaniline in Step 4.In Step 4, the desired fractions were evaporated to afford light yellow oil which was purified again using silica gel column chromatography (gradient elution: ethyl acetate in heptane from 40 to 70%).", "The desired fractions were combined and evaporated to afford compound 152 (332 mg) as white powder.", "Method B; Rt: 0.80 min.", "m/z: 405 (M−H)− Exact mass: 406.11.1H NMR (400 MHz, DMSO-d6) δ ppm 1.53 (s, 3H), 2.34 (s, 3H), 3.73 (s, 3H), 4.13 (d, J=6.4 Hz, 2H), 4.62 (d, J=5.9 Hz, 2H), 7.48 (s, 1H), 7.54 (t, J=9.1 Hz, 1H), 7.92 (br.", "s., 1H), 7.98 (ddd, J=9.2, 4.9, 2.9 Hz, 1H), 8.19 (dd, J=5.8, 2.8 Hz, 1H), 10.43 (br.", "s., 1H).", "Compound 153: N-[4-Fluoro-3-(trifluoromethyl)phenyl]-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 153 (270 mg) as beige solid was synthesized similarly as described for compound 144 using 1,3-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid (260 mg, 0.83 mmol) and 4-fluoro-3-(trifluoromethyl)aniline (0.31 g, 1.65 mmol) instead of 3,4-difluoroaniline in Step 4.Method B; Rt: 1.10 min.", "m/z: 474 (M−H)− Exact mass: 475.08.1H NMR (400 MHz, DMSO-d6) δ ppm 1.12 (d, J=6.8 Hz, 3H), 2.32 (s, 3H), 3.73 (s, 3H), 3.84 (quin, J=7.3 Hz, 1H), 7.48-7.56 (m, 2H), 7.91-8.00 (m, 1H), 8.12-8.24 (m, 2H), 10.41 (s, 1H).", "Synthesis of methyl 1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate In a pressure tube methyl 4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate (15 g, 63.11 mmol) was dissolved in 100 mL of dry acetonitrile.", "To this was added (S)-1,1,1-trifluoro-2-propylamine (8.56 g, 75.74 mmol) followed by diisopropylethylamine (27.19 mL, 157.79 mmol).", "The pressure tube was flushed with nitrogen and closed.", "The mixture was stirred in a pre-heated oil bath at 80° C. for 15 hours.", "Then it was cooled to room temperature and concentrated in vacuo.", "The obtained residue was dissolved in dichloromethane (400 mL) and this was washed with HCl (1M/aq/2×100 mL).", "The obtained organics were dried on Na2SO4, filtered and concentrated in vacuo resulting in Methyl 1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate as a beige powder (17.5 g) which was used as such.", "Method B; Rt: 0.83 min.", "m/z: 313.1 (M−H)− Exact mass: 314.05.Synthesis of 1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid Methyl 1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (6.6 g, 19.7 mmol) was dissolved in tetrahydrofuran (56 mL).", "To this was added lithium hydroxide (1.655 g, 69.1 mmol) in distilled water (7.5 mL) followed by methanol (3 mL).", "The resulting mixture was stirred overnight.", "The mixture was concentrated until only water remained and extra distilled water (15 mL) was added.", "The mixture was neutralised with hydrochloric acid (1M, aq).", "The resulting mixture was extracted using 2-methyltetrahydrofuran (3×20 mL).", "The combined extracts were dried on sodium sulphate, filtered and concentrated in vacuo yielding 1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid (5.34 g).", "Method B; Rt: 0.45 min.", "m/z: 299.0 (M−H)− Exact mass: 300.04.Compound 154: 1-Methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-N-(2,3,4-trifluorophenyl)-1H-pyrrole-2-carboxamide 1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid (500 mg, 1.67 mmol) was dissolved in of N,N-dimethylformamide (1 mL).", "Then HATU (0.76 g, 2 mmol) was added and this mixture was stirred for 20 minutes.", "Then diisopropylethylamine (0.86 mL, 5 mmol) was added followed by 2,3,4-trifluoroaniline (0.49 g, 3.33 mmol).", "The reaction mixture was stirred at 50° C. for 5 hours.", "Then this mixture was cooled to room temperature and injected directly onto a silica plug.", "The mixture was purified by silica gel column chromatography using gradient elution from heptane to EtOAc.", "(100:0 to 0:100) yielding compound 154 as a white powder (253 mg) Method B; Rt: 0.99 min.", "m/z: 428.1 (M−H)− Exact mass: 429.06.1H NMR (400 MHz, DMSO-d6) δ ppm, 1.09 (d, J=7.0 Hz, 3H), 3.90 (s, 3H), 3.91-4.02 (m, 1H), 7.24-7.48 (m, 3H), 7.65 (d, J=1.8 Hz, 1H), 7.76-8.97 6 (br.s, 1H), 9.58-11.00 (br.s, 1H).", "Compound 155: N-(3-Bromo-2,4-difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 155 (314 mg) was prepared similarly as described for compound 154 using 3-bromo-2,4-difluoro-aniline (0.69 g, 3.33 mmol) instead of 2,3,4-trifluoroaniline resulting in white powder.", "Method B; Rt: 1.04 min.", "m/z: 490.03 (M−H)− Exact mass: 491.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.09 (d, J=7.0 Hz, 3H), 3.90 (s, 3H), 3.91-4.02 (m, 1H), 7.23-7.39 (m, 2H), 7.57 (td, J=8.7, 5.9 Hz, 1H), 7.64 (d, J=1.5 Hz, 1H), 8.18 (br.", "s., 1H), 10.12 (br.", "s., 1H).", "Compound 156: N-(3-Chloro-2,4-difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 156 (289 mg) was prepared similarly as compound 154 using 3-chloro-2,4-difluoro-aniline (0.54 g, 3.33 mmol) instead of 2,3,4-trifluoroaniline resulting in white powder.", "Method B; Rt: 1.03 min.", "m/z: 444.11 (M−H)− Exact mass: 445.03.1H NMR (400 MHz, DMSO-d6) δ ppm 1.09 (d, J=6.8 Hz, 3H), 3.90 (s, 3H), 3.91-4.00 (m, 1H), 7.29-7.43 (m, 2H), 7.53 (td, J=8.7, 5.9 Hz, 1H), 7.64 (d, J=1.8 Hz, 1H), 8.17 (br.", "s., 1H), 10.14 (br.", "s., 1H).", "Compound 157: N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]pyrrole-2-carboxamide Prepared similarly as described for compound 123 using 5-amino-2-fluoro-benzonitrile (580.5 mg, 4.14 mmol) instead of 3-chloro-4-fluoro-aniline, resulting in compound 157 as a white powder (136 mg).", "Method B; Rt: 0.96 min.", "m/z: 417.13 (M−H)− Exact mass: 418.07.1H NMR (400 MHz, DMSO-d6) δ ppm 1.08 (d, J=6.8 Hz, 3H), 3.82-4.00 (m, 4H), 7.36 (d, J=2.0 Hz, 1H), 7.43-7.59 (m, 1H), 7.65 (d, J=1.5 Hz, 1H), 7.96-8.04 (m, 1H), 8.05-8.33 (m, 2H), 10.38 (br.", "s., 1H).", "Compound 158: N-(3-Cyanophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]-sulfamoyl}-1H-pyrrole-2-carboxamide To methyl 1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (5.0 g, 15.91 mmol, prepared as in the synthesis for compound 122) dissolved in dioxane (59 mL) and water (10 mL) was added LiOH (2.34 g, 55.68 mmol) and the reaction mixture stirred 16 h. The mixture was concentrated in vacuo.", "The residue was dissolved in water and acidified with 1N HCl solution till pH-3.The mixture was stirred at room temperature for 30′.", "The product was filtered off and dried in vacuo to become a pale yellow solid of 1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid (3.95 g).", "This acid (700 mg, 2.33 mmol), 3-aminobenzonitrile (347.8 mg, 2.91 mmol), HATU (1108 mg, 2.914 mmol) and DIPEA (1.2 mL, 6.99 mmol) was dissolved in DMF (7 mL) and the mixture was stirred at room temperature for 16 h. The mixture was poured in 100 mL ice water and was extracted with EtOAc.", "The organic layer was separated, washed with brine, dried (MgSO4), filtered and concentrated in vacuo.", "The residue was purified on a silica using a gradient eluent Heptane-EtOAc 100-0->50-50.The product fractions were collected and concentrated in vacuo.", "The product was crystallized from 2-propanol, filtered off and dried in vacuo, yielding compound 158 (518 mg) as a white solid.", "Method B; Rt: 0.93 min.", "m/z: 399.1 (M−H)− Exact mass: 400.08 1H NMR (600 MHz, DMSO-d6) δ ppm 1.08 (d, J=7.04 Hz, 3H) 3.86-4.00 (m, 4H) 7.39 (d, J=1.91 Hz, 1H) 7.50-7.61 (m, 2H) 7.66 (d, J=1.61 Hz, 1H) 7.99 (dt, J=7.56, 2.02 Hz, 1H) 8.12-8.21 (m, 2H) 10.35 (s, 1H).", "Compound 159: N-[2-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 159 (582 mg) was prepared similarly as described for compound 158 using 3-amino-2-fluorobenzotrifluoride (0.387 mL, 2.91 mmol) instead of 3-aminobenzonitrile resulting in a white solid.", "Method B; Rt: 1.06 min.", "m/z: 460.1 (M−H)− Exact mass: 461.06.1H NMR (400 MHz, DMSO-d6) δ ppm 1.10 (d, J=6.8 Hz, 3H), 3.87-3.98 (m, 4H), 7.37-7.47 (m, 2H), 7.61-7.67 (m, 2H), 7.88 (t, J=7.2 Hz, 1H), 8.19 6 (d, J=8.4 Hz, 1H), 10.21 (s, 1H).", "Compound 160: N-(3-Cyano-2-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 160 (202 mg) was prepared similarly as described for compound 158 using 3-amino-2-fluorobenzonitrile (396.7 mg, 2.91 mmol) instead of 3-aminobenzonitrile resulting in a white solid.", "Method B; Rt: 0.92 min.", "m/z: 417.1 (M−H)− Exact mass: 418.07.1H NMR (400 MHz, DMSO-d6) δ ppm 1.10 (d, J=7.0 Hz, 3H), 3.89-3.99 (m, 4H), 7.38 (d, J=2.0 Hz, 1H), 7.43 (t, J=7.9 Hz, 1H), 7.67 (d, J=1.8 Hz, 1H), 6 7.78 (ddd, J=7.8, 5.9, 1.5 Hz, 1H), 7.88-7.93 (m, 1H), 8.19 (d, J=8.6 Hz, 1H), 10.26 (s, 1H).", "Compound 161: N-[3-(1,1-Difluoroethyl)-4-fluorophenyl]-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Synthesis of 2-(1,1-difluoroethyl)-1-fluoro-4-nitro-benzene 1-(2-fluoro-5-nitrophenyl)ethanone (19 g, 103.7 mmol) was dissolved in dichloromethane (300 mL) The mixture was stirred at −78° C. under N2-atmosphere.", "Diethylamino)sulfur trifluoride (33.4 g, 207 mmol) was added to the mixture via cannula over a period of 30 min.", "The reaction mixture was stirred at 35° C. for 16 h. The cold reaction mixture was poured into ice water (200 mL).", "The aqueous layer was extracted with dichloromethane (80 mL) twice.", "The combined organic layers were washed with water, dried over sodium sulfate and evaporated to dryness to provide a yellow oil.", "The crude product was purified by column chromatography to provide a yellow oil (13 g).", "Synthesis of 3-(1,1-difluoroethyl)-4-fluoro-aniline 2-(1,1-difluoroethyl)-1-fluoro-4-nitrobenzene (13 g, 63.37 mmol) was dissolved in methanol (65 mL) and water (65 mL).", "Iron powder (10.6 g) and HCl (25 mL) were added.", "The mixture was stirred at room temperature for 45 min.", "The reaction mixture was then filtered through celite, the filtrate was washed with saturated solution of sodium carbonate and dried over sodium sulfate and evaporated to dryness to provide a yellow oil.", "The crude product was purified by column chromatography to provide a yellow oil (5845 mg).", "Synthesis of 5-[[3-(1,1-difluoroethyl)-4-fluoro-phenyl]carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride 3-(1,1-difluoroethyl)-4-fluoro-aniline (1099.8 mg, 6.28 mmol) dissolved in toluene (10 mL) was added dropwise during 5′ to a solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride (1520 mg, 6.28 mmol) in toluene (100 mL) at reflux.", "The reaction mixture was refluxed 90 minutes and then concentrated in vacuo, yielding a brown powder which was used as such (2566 mg) Method A; Rt: 2.01 min.", "m/z: 378.9 (M−H)− Exact mass: 380.02.3-methyloxetan-3-amine (390 mg, 4.47 mmol) was added to a solution of 5-[[3-(1,1-difluoroethyl)-4-fluoro-phenyl]carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (605 mg, 1.49 mmol) in CH3CN (50 mL) and stirred 17 hr.", "Water was added until crystallisation began.", "The white powder was filtered off and dried overnight in vacuo at 50° C., resulting in compound 161 (514 mg); Method A; Rt: 1.70 min.", "m/z: 430.1 (M−H)− Exact mass: 431.11.1H NMR (400 MHz, DMSO-d6) δ ppm 1.55 (s, 3H), 1.95-2.06 (m, 3H), 3.92 (s, 3H), 4.14 (d, J=6.4 Hz, 2H), 4.60 (d, J=5.9 Hz, 2H), 7.35 (d, J=2.0 Hz, 2H), 7.59 (d, J=1.8 Hz, 1H), 7.85-7.92 (m, 1H), 7.93-8.02 (m, 2H), 10.23 (s, 1H).", "Compound 162: 4-(tert-Butylsulfamoyl)-N-[3-(1,1-difluoroethyl)-4-fluorophenyl]-1-methyl-1H-pyrrole-2-carboxamide tert-butylamine (400.6 mg, 5.48 mmol) was added to a solution of 5-[[3-(1,1-difluoroethyl)-4-fluoro-phenyl]carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (622 mg, 1.53 mmol) in CH3CN (50 mL) and stirred 17 hr.", "Water was added until crystallisation began.", "The white powder was filtered off and dried overnight in vacuo at 50° C., resulting in compound 162 (355 mg).", "Method A; Rt: 1.91 min.", "m/z: 416.1 (M−H)− Exact mass: 417.13.1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (s, 9H), 1.93-2.08 (m, 3H), 3.91 (s, 3H), 7.11 (s, 1H), 7.27-7.37 (m, 2H), 7.52 (d, J=1.5 Hz, 1H), 7.85-7.93 6 (m, 1H), 7.96-8.02 (m, 1H), 10.21 (s, 1H).", "Compound 163: N-(3,5-Dichloro-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide 3,5-dichloro-4-fluoroaniline (1534 mg, 18.52 mmol) dissolved in toluene (10 mL) was added to 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride (2063 mg, 8.52 mmol) in toluene (125 mL) at reflux and refluxed 2 hours.", "The reaction mixture was filtered while still hot and concentrated yielding a crude beige powder (2833 mg, 5-[(3,5-dichloro-4-fluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride) which was used as such.", "1H NMR (400 MHz, ACETONITRILE-d3) δ ppm 3.96 (s, 3H), 7.39 (d, J=2.0 Hz, 1H), 7.71-7.77 (m, 3H), 8.78 (br.", "s., 1H) 2,2,2-trifluoro-1,1-dimethyl-ethylamine (692 mg, 5.45 mmol) was added to 5-[(3,5-dichloro-4-fluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (700.2 mg, 1.82 mmol) and DIPEA (0.47 mL, 2.72 mmol) dissolved in CH3CN (66 mL) and refluxed overnight.", "The reaction mixture was concentrated.", "The residue was dissolved in EtOAc, washed with 1M HCl, dried over sodium sulphate, filtered and concentrated.", "The residue was purified by column chromatography on silica using a gradient from 10 till 100% EtOAc in heptane.", "The obtained powder was recrystallized from methanol (25 mL), upon addition of water and further purified by Prep HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm), Mobile phase: 0.25% NH4HCO3 solution in water, MeOH), yielding a white powder which was dried in vacuo at 50° C. during 6 hours.", "Method A; Rt: 2.13 min.", "m/z: 473.9 (M−H)− Exact mass: 475.01.1H NMR (400 MHz, DMSO-d6) δ ppm 1.36 (s, 6H), 3.92 (s, 3H), 7.34 (d, J=2.0 Hz, 1H), 7.61 (d, J=1.5 Hz, 1H), 7.95 (d, J=6.2 Hz, 2H), 8.07 (s, 1H), 6 10.30 (s, 1H).", "Compound 164: N-(3-Chloro-4,5-difluorophenyl)-4-[(3,3-difluorocyclobutyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide A mixture of 5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (561.7 mg, 1.15 mmol) (prepared as in the synthesis for compound 57) 3,3-difluorocyclobutanamine hydrochloride (248.5 mg, 1.73 mmol) DIPEA (0.6 mL, 3.46 mmol) in CH3CN (22 mL) was stirred overnight at room temperature.", "The reaction mixture was concentrated.", "The residue was subjected to column chromatography on silica using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were partially concentrated until product crystallized.", "The white crystals were filtered off and dried overnight in vacuo at 50° C., resulting in compound 164 (175 mg) Method A: Rt: 1.86 min m/z: 438.0 (M−H)− Exact mass: 439.04.1H NMR (400 MHz, DMSO-d6) δ ppm 2.36-2.58 (m, 2H), 2.72-2.90 (m, 2H), 3.48-3.63 (m, 1H), 3.92 (s, 3H), 7.34 (d, J=1.8 Hz, 1H), 7.63 (d, J=1.8 6 Hz, 1H), 7.75-7.88 (m, 3H), 10.29 (s, 1H)1H NMR (400 MHz, ACETONITRILE-d3) δ ppm 2.40-2.58 (m, 2H), 2.74-2.89 (m, 2H), 3.59-3.72 (m, 1H), 3.93 (s, 3H), 5.84 (d, J=1.0 Hz, 1H), 7.13 3 (d, J=1.8 Hz, 1H), 7.36 (d, J=1.8 Hz, 1H), 7.56-7.61 (m, 1H), 7.61-7.69 (m, 1H), 8.63 (s, 1H).", "Compound 165: N-(3-chloro-4,5-difluoro-phenyl)-1-methyl-4-[[1-methyl-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide A mixture of 5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (1034 mg. 12 mmol) (prepared as in the synthesis for compound 57) 1,1,1-trifluoro-2-methyl-butan-2-amine hydrochloride (754 mg, 4.25 mmol) DIPEA (1.14 mL, 36.58 mmol) in CH3CN (31 mL) was refluxed 2 days.", "The reaction mixture was concentrated.", "The residue was dissolved in EtOAc (100 mL), washed with 1M HCl, dried over sodium sulphate, filtered and concentrated.", "The residue was subjected to column chromatography on silica using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated yielding compound 165 (300.1 mg) as a white solid.", "The racemic mixture 165 was separated in enantiomers 165a and 165b by Prep SFC (Stationary phase: Chiralpak Diacel AD 20×250 mm), Mobile phase: CO2, iPrOH with 0.2% iPrNH2), the desired fractions were collected, evaporated, dissolved in MeOH and evaporated again, yielding 165a (first eluding, white solid, 45 mg).", "Method A: Rt: 2.10 min m/z: 472.0 (M−H)− Exact mass: 473.06.1H NMR (400 MHz, DMSO-d6) δ ppm 0.79 (t, J=7.3 Hz, 3H), 1.37 (s, 3H), 1.45-1.59 (m, 1H), 1.73-1.87 (m, 1H), 3.92 (s, 3H), 7.34 (d, J=1.8 Hz, 1H), 7.59 (d, J=1.8 Hz, 1H), 7.76-7.86 (m, 2H), 7.90 (s, 1H), 10.31 (s, 1H) and 165b (second eluding, 40 mg, white solid).", "Method A: Rt: 2.10 min m/z: 472.0 (M−H)− Exact mass: 473.06.1H NMR (400 MHz, DMSO-d6) δ ppm 0.79 (t, J=7.3 Hz, 3H), 1.37 (s, 3H), 1.46-1.59 (m, 1H), 1.74-1.87 (m, 1H), 3.92 (s, 3H), 7.34 (d, J=1.8 Hz, 1H), 7.59 (d, J=1.8 Hz, 1H), 7.76-7.86 (m, 2H), 7.90 (s, 1H), 10.31 (s, 1H).", "Compound 166: N-(3-Chloro-4,5-difluorophenyl)-4-[(3,3-difluorocyclopentyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide A mixture of 5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (1496 mg. 3.07 mmol) (prepared as in the synthesis for compound 57) 3,3-difluorocyclopentanamine (819 mg, 6.76 mmol) DIPEA (0.79 mL, 4.61 mmol) in CH3CN (23 mL) was refluxed 1 hour.", "The reaction mixture was concentrated.", "The residue was dissolved in EtOAc (100 mL), washed with 1M HCl, dried over sodium sulphate, filtered and concentrated.", "The residue was subjected to column chromatography on silica using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were partially concentrated until the product started to crystallize.", "The white crystals were filtered off and dried overnight in vacuo at 50° C., resulting in compound 166 (856.3 mg) Method A: Rt: 1.87 min m/z: 452.0 (M−H)− Exact mass: 453.05.1H NMR (400 MHz, DMSO-d6) δ ppm 1.56-1.75 (m, 1H), 1.87-2.07 (m, 3H), 2.07-2.23 (m, 1H), 2.24-2.40 (m, 1H), 3.55-3.70 (m, 1H), 3.92 (s, 3H), 7.34 (d, J=2.0 Hz, 1H), 7.62 (d, J=1.5 Hz, 1H), 7.65 (d, J=6.8 Hz, 1H), 7.77-7.86 (m, 2H), 10.31 (s, 1H) Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 198.05° C. The racemic mixture 166 was separated in enantiomers 166a and 166b by Prep SFC (Stationary phase: Chiralpak Diacel AD 20×250 mm), Mobile phase: CO2, MeOH-iPrOH (50-50) with 0.2% iPrNH2), the desired fractions were collected, evaporated, dissolved in MeOH and evaporated again, The residues were dissolved in methanol (20 mL) and crystallized upon addition of water.", "The white powders were filtered off and dried overnight in vacuo at 50° C., resulting in compound 166a (285.5 mg, first eluding enantiomer), 166b (296 mg, second eluding enantiomer) Method A: Rt: 1.96 min m/z: 452.0 (M−H)− Exact mass: 453.05.1H NMR (400 MHz, DMSO-d6) δ ppm 1.58-1.73 (m, 1H), 1.88-2.07 (m, 3H), 2.07-2.23 (m, 1H), 2.24-2.41 (m, 1H), 3.57-3.69 (m, 1H), 3.92 (s, 3H), 7.34 (d, J=1.8 Hz, 1H), 7.62 (d, J=1.5 Hz, 1H), 7.65 (d, J=6.6 Hz, 1H), 7.75-7.87 (m, 2H), 10.31 (s, 1H).", "Compound 167: 4-(Bicyclo[1.1.1]pent-1-ylsulfamoyl)-N-(3-chloro-4,5-difluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide Compound 167 was prepared similarly as described for compound 164 using bicyclo[1.1.1]pentan-1-amine hydrochloride instead of 3,3-difluorocyclobutanamine hydrochloride.", "The product fractions after column chromatography were concentrated and the residue dissolved in hot methanol (25 mL).", "The product crystallized upon addition of a small amount of water.", "The white powder was filtered off and dried overnight in vacuo at 50° C., resulting in compound 167 (226 mg) Method A: Rt: 1.89 min m/z: 414.0 (M−H)− 416.0 (M+H)+ Exact mass: 415.06.1H NMR (400 MHz, DMSO-d6) δ ppm 1.81 (s, 6H), 2.31 (s, 1H), 3.93 (s, 3H), 7.34 (d, J=2.0 Hz, 1H), 7.58 (d, J=1.5 Hz, 1H), 7.77-7.86 (m, 2H), 8.22 (s, 1H), 10.29 (s, 1H).", "Compound 168: N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-[(3,3,3-trifluoropropyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 168 was prepared similarly as described for compound 164 using 3,3,3-trifluoropropylamine instead of 3,3-difluorocyclobutanamine hydrochloride but was stirred 3 hours at room temperature.", "Water was added until the product start to crystallize.", "The white powder was filtered off and dried overnight in vacuo at 50° C. Method A: Rt: 1.95 min m/z: 444.0 (M−H)− Exact mass: 445.03 1H NMR (400 MHz, DMSO-d6) δ ppm 2.40-2.55 (m, 2H), 2.95-3.05 (m, 2H), 3.92 (s, 3H), 7.35 (d, J=2.0 Hz, 1H), 7.52 (t, J=5.9 Hz, 1H), 7.65 (d, J=1.8 6 Hz, 1H), 7.76-7.86 (m, 2H), 10.31 (s, 1H).", "Compound 169: N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-[(3,3,3-trifluoro-1-methylpropyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 169 was prepared similarly as compound 164 using 4,4,4-trifluorobutan-2-amine hydrochloride instead of 3,3-difluorocyclobutanamine hydrochloride.", "Water was added until the product starts to crystallize.", "The white powder was filtered off and dried overnight in vacuo at 50° C., resulting in compound 169 (542 mg).", "Method A: Rt: 1.91 min m/z: 458.0 (M−H)− Exact mass: 459.04.1H NMR (400 MHz, DMSO-d6) δ ppm 1.06 (d, J=6.8 Hz, 3H), 2.32-2.47 (m, 2H), 3.43-3.55 (m, 1H), 3.92 (s, 3H), 7.34 (d, J=1.8 Hz, 1H), 7.55 (d, J=7.9 Hz, 1H), 7.62 (d, J=1.8 Hz, 1H), 7.76-7.86 (m, 2H), 10.30 (s, 1H).", "The racemic compound 169 (492 mg) was separated in enantiomers 169a and 169b by Prep SFC (Stationary phase: Chiralpak Diacel AD 20×250 mm), Mobile phase: CO2, MeOH with 0.2% iPrNH2), the desired fractions were collected, evaporated, solved in MeOH and evaporated again.", "The residue was crystallized from 25 mL methanol upon addition of water, filtered off and dried overnight in vacuo at 50° C. yielding white crystals, resulting in compound 169a (first eluding enantiomer, 144 mg) and 169b (second eluding enantiomer, 135 mg).", "Compound 170: N-(3-Cyano-4-fluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Ethyl 4-chlorosulfonyl-3-fluoro-1-methyl-pyrrole-2-carboxylate (prepared similarly as described in the synthesis of 3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylic acid for compound 74, from 5-ethoxycarbonyl-4-fluoro-1-methyl-pyrrole-3-sulfonic acid (heating 60 minutes at 80° C. in thionylchloride instead of 30 minutes at 80° C.; 4880 mg, 19.4 mmol) was dissolved in CH3CN (50 mL), DIPEA (10.04 mL, 58.27 mmol) was added followed by (2R)-1,1,1-trifluoropropan-2-amine (3295 mg, 29.14 mmol) and the mixture was refluxed for 3 hours.", "The reaction mixture was concentrated.", "The residue was dissolved in EtOAc (200 mL), washed with water, dried over sodium sulphate, filtered and concentrated.", "The residue was purified by column chromatography on silica using a gradient from 5 till 100% EtOAc in heptane.", "The product fractions were concentrated in vacuo yielding ethyl 3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate as a light brown semisolid which was used as such (1705 mg).", "Method A: Rt 1.68 min, m/z: 345 (M−H)− 347.0 (M+H)+ Exact mass: 346.06.A mixture of ethyl 3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (1705 mg, 4.92 mmol), LiOH (354 mg, 14.77 mmol) THF (17 mL) and water (4 mL) was stirred overnight.", "The reaction mixture was concentrated, the residue dissolved in water (50 mL) and the solution was neutralised with HCl 1M (14.77 mL, 14.77 mmol).", "The mixture was extracted with Me-THF (2×100 mL).", "The organic layer was dried over sodium sulphate, filtered and concentrated resulting in 3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid (1533 mg) as a powder, which was used as such.", "Method A: Rt: 0.88 m/z: 317 (M−H)− Exact mass: 318.03.1H NMR (400 MHz, DMSO-d6) δ ppm 1.15 (d, J=7.0 Hz, 3H), 3.82 (s, 3H), 3.88-4.04 (m, 1H), 7.56 (d, J=4.8 Hz, 1H), 8.56 (d, J=8.8 Hz, 1H), 13.13 (br.", "s., 1H).", "Compound 170 (531 mg) was synthesized similarly as described for compound 94 using 3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid (601.7 mg 1.89 mmol) instead of 3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylic acid and 5-amino-2-fluorobenzonitrile (531 mg, 3.78 mmol) instead of 4-fluoro-3-methylaniline and the reaction mixture was stirred overnight at 65° C. The column fractions were concentrated and the residue was crystallized by dissolving in 100 mL warm methanol upon addition of water.", "The crystals were filtered off and dried overnight in vacuo at 50° C. Method A: Rt: 1.66 min m/z: 435 (M−H)− Exact mass: 436.06.1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (d, J=6.8 Hz, 3H), 3.81 (s, 3H), 3.91-4.05 (m, 1H), 7.50-7.59 (m, 2H), 7.96 (ddd, J=9.2, 5.0, 2.8 Hz, 1H), 8.17 (dd, J=5.8, 2.8 Hz, 1H), 8.62 (d, J=8.8 Hz, 1H), 10.36 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 190.99° C. Alternative Synthesis of Compound 170: Sodium hydride (6.99 g, 183 mmol) was added portionwise to ethyl 3-fluoropyrrole-2-carboxylate (23.9 g, 152 mmol), iodomethane (25.9 g, 183 mmol) in DMF (238 mL) under nitrogen in an icebath and stirred overnight at room temperature.", "The reaction mixture was acidified with 1M HCl and concentrated.", "The residue was dissolved in water/EtOAc.", "The organic layer was dried over Na2SO4, filtered and concentrated.", "The obtained residue was dissolved in CH3CN (150 mL), washed with heptane and concentrated at 60° C. and 40 mbar yielding a brown liquid which was submitted to silica gel column chromatography using a gradient from 10 to 25% EtOAc in heptane.", "The product fractions were concentrated resulting in ethyl 3-fluoro-1-methyl-pyrrole-2-carboxylate as a clear oil (14.0 g).", "Chlorosulfonic acid (9.97 g, 85.6 mmol) dissolved in dichloromethane (50 mL) was added to ethyl 3-fluoro-1-methyl-pyrrole-2-carboxylate (14.0 g, 81.5 mmol) dissolved in dichloromethane (250 mL) in an icebath and stirred 30 minutes.", "The formed light beige crystals were filtered off and dried overnight in vacuo at 50° C., resulting in 5-ethoxycarbonyl-4-fluoro-1-methyl-pyrrole-3-sulfonic acid (14.3 g).", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.26 (t, J=7.2 Hz, 3H), 3.72 (s, 3H), 4.23 (q, J=7.0 Hz, 2H), 7.02 (d, J=5.1 Hz, 1H).", "Method D: Rt: 0.88 min.", "m/z: 250.0 (M−H)− Exact mass: 251.0.5-ethoxycarbonyl-4-fluoro-1-methyl-pyrrole-3-sulfonic acid (20.3 g, 80.7 mmol) in SOCl2 (80 mL, 1.1 mol) was stirred 2 hours at 80° C. The reaction mixture was concentrated.", "The obtained dark green solid was subjected to silica gel column chromatography using a gradient from 10 to 50% EtOAc in heptane.", "The product fractions were concentrated yielding ethyl 4-chlorosulfonyl-3-fluoro-1-methyl-pyrrole-2-carboxylate (18.9 g) as light yellow crystals which was used as such.", "Ethyl 4-chlorosulfonyl-3-fluoro-1-methyl-pyrrole-2-carboxylate (18.9 g, 70.1 mmol) (2R)-1,1,1-trifluoropropan-2-amine (11.89 g, 105.2 mmol) NaHCO3 (17.7 g, 210 mmol) in acetonitrile (150 mL) with molecular sieves 4A (15 g) and was refluxed overnight.", "The reaction mixture was filtered and concentrated.", "The residue was dissolved in EtOAc and washed with 1 M HCl.", "The organic layer was dried over sodium sulphate, filtered and concentrated.", "The residue was purified via silica gel column chromatography (2×) using a gradient from 10 to 100% EtOAc in heptane, resulting in ethyl 3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate as a white powder which was dried overnight at 50° C. in vacuo (19.1 g in total).", "Method D: Rt: 1.77 min.", "m/z: 345.0 (M−H)− Exact mass: 346.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.15 (d, J=7.0 Hz, 3H), 1.28 (t, J=7.2 Hz, 3H), 3.83 (s, 3H), 3.90-4.03 (m, 1H), 4.28 (q, J=7.2 Hz, 2H), 7.60 (d, J=4.8 Hz, 1H), 8.60 (d, J=8.8 Hz, 1H).", "To ethyl 3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (10.0 g, 28.9 mmol) and 5-amino-2-fluoro-benzonitrile (5.11 g, 37.6 mmol)) dissolved in dry THF (200 mL) at 5° C. under nitrogen atmosphere, lithium bis(trimethylsilyl)amide in toluene (115.6 mL, 1 M, 115.6 mmol) was added.", "The mixture was stirred 4 hours allowing to reach room temperature.", "The reaction mixture was quenched with NH4Cl (250 mL) solution and extracted with EtOAc (500 mL), diluted with brine (200 mL) and extracted again with EtOAc (300 mL).", "The combined organic layers were dried over sodium sulphate, filtered and concentrated.", "The residue was purified by silica gel column chromatography with a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated and the solid residue was crystallised from warm methanol (300 mL) upon addition of water.", "The pink crystals were filtered off and dried in vacuo at 50° C. overnight.", "The compound was repeatedly purified by silica gel chromatography (using 10 to 100% EtOAc in heptane and using dichloromethane).", "The resulting product was crystallised once more from hot methanol (500 mL) and the product crystallised upon addition of water.", "The white powder was filtered off and dried overnight in vacuo at 50° C., resulting in compound 170 (9.28 g).", "Method D: Rt: 1.86 min m/z: 435.3 (M−H)− Exact mass: 436.1.Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 192.2° C. [α]58920=−23.2° (c 0.504 w/v %, DMF).", "Compound 171: N-(3-Cyano-4-fluorophenyl)-3-fluoro-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Intermediate ethyl 3-fluoro-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxylate was made similarly as described for ethyl 3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate starting from 5-ethoxycarbonyl-4-fluoro-1-methyl-pyrrole-3-sulfonic acid (1220 mg, 4.86 mmol), converting it to the sulphonyl chloride with thionyl chloride (heating at 80° C. during 1 hour) and reaction with isopropylamine (1160 mg, 19.42 mmol) resulting in ethyl 3-fluoro-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxylate (1169 mg) as a white powder.", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.03 (d, J=6.6 Hz, 6H), 1.28 (t, J=7.2 Hz, 3H), 3.26-3.37 (m, 1H), 3.82 (s, 3H), 4.27 (q, J=7.2 Hz, 2H), 7.52 (d, J=4.6 Hz, 1H), 7.56 (d, J=7.3 Hz, 1H) Method A: Rt: 1.48 min m/z: 291 (M−H)− Exact mass: 292.09.Intermediate 3-fluoro-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxylic acid was made similarly as for compound 170 using ethyl 3-fluoro-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxylate (1169 mg, 4.0 mmol) The reaction mixture was concentrated.", "The residue was dissolved in water (75 mL) and neutralised with HCl 1M (12.0 mL, 12.0 mmol).", "The product crystallized and was filtered off.", "The white powder was dried overnight in vacuo at 50° C., resulting in 3-fluoro-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxylic acid (856 mg) Method A: Rt: 0.75 min m/z: 263.0 (M−H)− Exact mass: 264.06.1H NMR (400 MHz, DMSO-d6) δ ppm 1.02 (d, J=6.6 Hz, 6H), 3.22-3.38 (m, 1H), 3.81 (s, 3H), 7.47 (d, J=4.8 Hz, 1H), 7.54 (d, J=7.5 Hz, 1H), 13.06 (s, 1H).", "Compound 171 was made similarly as compound 170 using 3-fluoro-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxylic acid (594 mg, 2.25 mmol) resulting in compound 171 (670 mg) as a white powder.", "Method A: Rt: 1.59 min m/z: 381 (M−H)− Exact mass: 382.09.1H NMR (400 MHz, DMSO-d6) δ ppm 1.05 (d, J=6.6 Hz, 6H), 3.26-3.42 (m, 1H), 3.80 (s, 3H), 7.48 (d, J=4.6 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.59 (d, J=7.3 Hz, 1H), 7.96 (ddd, J=9.2, 4.9, 2.6 Hz, 1H), 8.17 (dd, J=5.8, 2.8 Hz, 1H), 10.32 (s, 1H) Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 204.47° C. Compound 172: N-(3-Chloro-2,4-difluorophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide 4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxylic acid (250 mg, 1.02 mmol was dissolved in CH3CN (15 mL).", "Triethylamine (0.56 mL), 3-chloro-2,4-difluoroaniline (183 mg, 1.12 mmol) and HATU (463 mg, 1.22 mmol) were added.", "The reaction mixture was stirred at room temperature for 1 h, next at 50° C. for 80 h and then for 24 h at 75° C. The solution was allowed to cool down.", "The solvent was evaporated leaving a yellow oil which was dissolved in CH2Cl2/MeOH (2 mL, 95:5) and purified by Flash Chromatography on silica using a gradient of EtOAc-heptane 0/100 to 100/0].", "The desired fractions were combined and the solvent was evaporated leaving a brown stable foam which was dissolved in a boiling mixture of diisopropyl ether (3 mL) and CH3CN (0.5 mL).", "The solution was allowed to cool while stirring.", "The precipitate was filtered off, washed once with its own filtrate and with of diisopropyl ether (2 mL).", "The product was collected as a white solid and dried in vacuo at 50° C., resulting in compound 172 (60 mg).", "Method B: Rt: 0.98 min m/z: 390.1 (M−H)− Exact mass: 391.06.1H NMR (360 MHz, DMSO-d6) δ ppm 1.02 (d, J=6.6 Hz, 6H), 3.26 (dd, J=13.4, 6.8 Hz, 1H), 3.89 (s, 3H), 7.25 (d, J=6.6 Hz, 1H), 7.28-7.39 (m, 2H), 7.48-7.59 (m, 2H), 10.16 (s, 1H).", "Compound 173: N-(3-Chloro-2-fluorophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide 4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxylic acid (0.75 g, 3.05 mmol) was dissolved in N,N-dimethylformamide (2 mL).", "HATU (1.27 g, 3.35 mmol) was added and the mixture was stirred for 20 minutes.", "DIPEA (1.31 mL, 7.61 mmol) was added followed by 3-chloro-2-fluoroaniline (0.44 g, 3.05 mmol).", "The reaction mixture was stirred at 50° C. for 16 hours.", "Then this mixture was purified by silica gel column chromatography using gradient elution from heptane to EtOAc.", "(100:0 to 0:100).", "The desired fractions were concentrated in vacuo and the obtained residue was crystallized out of MeOH/water.", "The precipitate was collected on a glass filter and dried in a vacuum oven at 55° C. for 24 hours yielding compound 173 (477 mg) as a white powder.", "Method B: Rt: 0.97 min m/z: 372.1 (M−H)− Exact mass: 373.07.1H NMR (400 MHz, DMSO-d6) δ ppm 1.03 (d, J=6.6 Hz, 6H), 3.21-3.30 (m, 1H), 3.90 (s, 3H), 7.18-7.27 (m, 2H), 7.32 (d, J=1.8 Hz, 1H), 7.44 (ddd, J=8.2, 6.8, 1.5 Hz, 1H), 7.50 (ddd, J=8.1, 6.8, 1.8 Hz, 1H), 7.55 (d, J=1.8 Hz, 1H), 10.12 (s, 1H).", "Compound 174: N-(3-Chloro-4-fluorophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 174 (681 mg) was prepared similarly as described for compound 173 using 3-chloro-4-fluoroaniline (0.44 g, 3.05 mmol) instead of 3-chloro-2-fluoroaniline resulting in a white powder.", "Method B: Rt: 1.02 min m/z: 372.1 (M−H)− Exact mass: 373.07.1H NMR (400 MHz, DMSO-d6) δ ppm 1.02 (d, J=6.6 Hz, 6H), 3.19-3.29 (m, 1H), 3.92 (s, 3H), 7.20 (br.", "s., 1H), 7.32 (d, J=1.8 Hz, 1H), 7.39 (t, J=9.1 Hz, 1H), 7.55 (d, J=1.8 Hz, 1H), 7.66 (ddd, J=9.0, 4.2, 2.6 Hz, 1H), 8.02 (dd, J=6.8, 2.6 Hz, 1H 10.22 (br.", "s., 1H).", "Compound 175: N-(3-Cyano-4-fluorophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 175 (576 mg) was prepared similarly as described for compound 173 using 5-amino-2-fluorobenzonitrile (0.41 g, 3.05 mmol) instead of 3-chloro-2-fluoroaniline resulting in a white powder.", "Method B: Rt: 0.91 min m/z: 363.2 (M−H)− Exact mass: 364.10.1H NMR (400 MHz, DMSO-d6) δ ppm 1.02 (d, J=6.6 Hz, 6H), 3.18-3.29 (m, 1H), 3.92 (s, 3H), 7.22 (d, J=5.5 Hz, 1H), 7.34 (d, J=2.0 Hz, 1H), 7.49-7.56 (m, 1H), 7.57 (d, J=1.8 Hz, 1H), 7.89-8.10 (m, 1H), 8.15-8.27 (m, 1H), 10.37 (br.", "s., 1H).", "Compound 176: N-(3-Cyano-2-fluorophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 176 (294 mg) was prepared similarly as described for compound 173 using 3-cyano-2-fluoroaniline (0.41 g, 3.05 mmol) instead of 3-chloro-2-fluoroaniline resulting in a white powder.", "Method B: Rt: 0.85 min m/z: 363.1 (M−H)− Exact mass: 364.10.1H NMR (400 MHz, DMSO-d6) δ ppm 1.03 (d, J=6.4 Hz, 6H), 3.18-3.30 (m, 1H), 3.79-3.97 (m, 3H), 7.22 (d, J=6.8 Hz, 1H), 7.34 (d, J=2.0 Hz, 1H), 7.37-7.48 (m, 1H), 7.57 (d, J=1.8 Hz, 1H), 7.71-7.81 (m, 1H), 7.83-7.98 (m, 1H), 10.25 (br.", "s., 1H).", "Compound 177: N-(3-Cyanophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 177 (629 mg) was prepared similarly as described for compound 173 using 3-aminobenzonitrile (0.36 g, 3.05 mmol) instead of 3-chloro-2-fluoroaniline resulting in a white powder.", "Method A: Rt: 1.49 min m/z: 345.1 (M−H)− Exact mass: 346.11.1H NMR (400 MHz, DMSO-d6) δ ppm 1.02 (d, J=6.6 Hz, 6H), 3.20-3.30 (m, 1H), 3.93 (s, 3H), 7.21 (br.", "s., 1H), 7.36 (d, J=1.8 Hz, 1H), 7.48-7.61 (m, 3H), 7.94-8.04 (m, 1H), 8.11-8.26 (m, 1H), 10.34 (br.", "s., 1H).", "Compound 178: N-(3-Cyano-2,4-difluorophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 178 (244 mg) was prepared similarly as described for compound 173 using 3-amino-2,6-difluorobenzonitrile (0.47 g, 3.05 mmol) instead of 3-chloro-2-fluoroaniline resulting in a white powder.", "Method B: Rt: 0.89 min m/z: 381.1 (M−H)− Exact mass: 382.09.1H NMR (400 MHz, DMSO-d6) δ ppm 1.03 (d, J=6.6 Hz, 6H), 3.20-3.29 (m, 1H), 3.90 (s, 3H), 7.22 (d, J=6.8 Hz, 1H), 7.32 (d, J=1.8 Hz, 1H), 7.45 (td, J=8.9, 1.5 Hz, 1H), 7.56 (d, J=1.8 Hz, 1H), 7.94 (td, J=8.9, 6.2 Hz, 1H), 10.25 (br.", "s., 1H).", "Compound 179: N-[4-Fluoro-3-(trifluoromethyl)phenyl]-1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 179 was prepared similarly as described for compound 144 using 3-methyl-3-oxetanamine (2.29 g, 26.3 mmol) instead of (R)-1,1,1-trifluoro-2-propylamine in Step 2 and, in step 4, 1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylic acid (155 mg, 0.54 mmol), 4-fluoro-3-(trifluoromethyl)aniline (0.2 g, 1.08 mmol) and HATU (0.25 g, 0.65 mmol) were dissolved in DMF (0.72 mL) containing DIPEA (0.23 mL, 1.34 mmol).", "The reaction mixture was stirred at 40° C. for 42 hours and allowed to reach room temperature.", "The reaction mixture was purified using silica gel column chromatography (ethyl acetate in heptane from 10 to 70%).", "The desired fractions were combined and evaporated to afford light yellow oil.", "The yellow oil was purified using silica gel column chromatography (ethyl acetate in heptane from 40 to 70%) yielding compound 179 (93 mg) as white powder which was dried in vacuum oven at 50° C. Method B: Rt: 0.97 min m/z: 448.1 (M−H)− Exact mass: 449.10.1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (s, 3H), 2.34 (s, 3H), 3.73 (s, 3H), 4.13 (d, J=6.4 Hz, 2H), 4.63 (d, J=5.9 Hz, 2H), 7.48 (s, 1H), 7.52 (t, J=9.8 Hz, 1H), 7.89-8.00 (m, 2H), 8.20 (dd, J=6.6, 2.6 Hz, 1H), 10.42 (br.", "s., 1H).", "Compound 180: N-(3-Cyanophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 180 was prepared similarly as described for compound 170 using 3-amino-benzonitrile (138 mg, 1.16 mmol) instead of 5-amino-2-fluorobenzonitrile.", "The column fractions were concentrated and the residue was crystallized by dissolving in 10 mL warm methanol upon addition of water.", "The crystals were filtered off and dried overnight in vacuo at 50° C. resulting in a white powder (121 mg).", "Method A: Rt: 1.72 min m/z: 417.0 (M−H)− Exact mass: 418.07.1H NMR (360 MHz, DMSO-d6) δ ppm 1.18 (d, J=7.0 Hz, 3H), 3.81 (s, 3H), 3.91-4.05 (m, 1H), 7.54-7.61 (m, 3H), 7.89-7.96 (m, 1H), 8.14 (d, J=1.1 Hz, 1H), 8.64 (d, J=8.4 Hz, 1H), 10.40 (s, 1H).", "Compound 181: N-(3-Cyano-2,4-difluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 181 was prepared similarly as described for compound 180 using 3-amino-2,6-difluorobenzonitrile (143 mg, 0.928 mmol) instead of 3-aminobenzonitrile resulting in a white powder (79 mg).", "Method A: Rt: 1.77 min m/z: 453.0 (M−H)− Exact mass: 454.05.1H NMR (360 MHz, DMSO-d6) δ ppm 1.18 (d, J=7.0 Hz, 3H), 3.81 (s, 3H), 3.92-4.04 (m, 1H), 7.43-7.51 (m, 1H), 7.59 (d, J=4.4 Hz, 1H), 7.98-8.08 (m, 1H), 8.66 (d, J=8.8 Hz, 1H), 10.06 (s, 1H).", "Compound 182: N-(3-Cyano-2-fluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 182 was prepared similarly as described for compound 180 using 3-amino-2-fluorobenzonitrile (127.5 mg, 0.936 mmol) instead of 3-aminobenzonitrile resulting in a white powder (66 mg).", "Method A: Rt: 1.78 min m/z: 435.1 (M−H)− Exact mass: 436.06.1H NMR (360 MHz, DMSO-d6) δ ppm 1.18 (d, J=7.0 Hz, 3H), 3.82 (s, 3H), 3.91-4.06 (m, 1H), 7.43 (t, J=7.7 Hz, 1H), 7.59 (d, J=4.4 Hz, 1H), 7.78 (ddd, J=7.8, 5.9, 1.6 Hz, 1H), 8.03 (td, J=8.0, 1.6 Hz, 1H), 8.66 (d, J=8.8 Hz, 1H), 10.06 (s, 1H).", "Compound 183: 3-Fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-N-(2,3,4-trifluorophenyl)-1H-pyrrole-2-carboxamide Compound 183 was prepared similarly as described for compound 180 using 2,3,4-trifluoroaniline (136.8 mg, 0.911 mmol) instead of 3-aminobenzonitrile resulting in a white powder (79 mg).", "Method A: Rt: 1.89 min m/z: 446.0 (M−H)− Exact mass: 447.05.1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=7.0 Hz, 3H), 3.81 (s, 3H), 3.91-4.04 (m, 1H), 7.29-7.39 (m, 1H), 7.42-7.50 (m, 1H), 7.56 (d, J=4.6 Hz, 1H), 8.61 (d, J=8.8 Hz, 1H), 9.93 (s, 1H).", "Compound 184: N-(3-Bromo-2,4-difluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 184 was prepared similarly as described for compound 180 using 3-bromo-2,4-difluoroaniline (194.9 mg, 0.937 mmol) instead of 3-aminobenzene resulting in a white powder (115 mg).", "Method A: Rt: 1.98 min m/z: 508.0 (M−H)− Exact mass: 506.97.1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=7.0 Hz, 3H), 3.81 (s, 3H), 3.90-4.04 (m, 1H), 7.27-7.35 (m, 1H), 7.56 (d, J=4.4 Hz, 1H), 7.64-7.73 (m, 1H), 8.61 (d, J=8.8 Hz, 1H), 9.86 (s, 1H).", "Compound 185: N-(3-Chloro-2,4-difluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 185 was prepared similarly as described for 180 using 3-chloro-2,4-difluoroaniline (150.9 mg, 0.923 mmol) instead of 3-aminobenzene resulting in a white powder (115 mg).", "Method A: Rt: 1.97 min m/z: 462.0 (M−H)− Exact mass: 463.02.1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=6.8 Hz, 3H), 3.81 (s, 3H), 3.92-4.04 (m, 1H), 7.35 (td, J=8.9, 2.0 Hz, 1H), 7.56 (d, J=4.6 Hz, 1H), 7.65 (td, J=8.7, 5.8 Hz, 1H), 8.61 (d, J=8.6 Hz, 1H), 9.88 (s, 1H).", "Compound 186: N-(3-Cyano-4-fluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-1-methyl-propyl]sulfamoyl}-1H-pyrrole-2-carboxamide Intermediate ethyl 3-fluoro-1-methyl-4-[[(1R)-1-methylpropyl]sulfamoyl]pyrrole-2-carboxylate was made similarly as described for compound 170 using 5-ethoxycarbonyl-4-fluoro-1-methyl-pyrrole-3-sulfonic acid (541.4 mg, 2.155 mmol), converting it to the corresponding sulphonylchloride with thionylchloride (heating at 80° C. during 90’) and reacting this with (R)-(−)-2-aminobutane (238.8 mg, 3.233 mmol) resulting in ethyl 3-fluoro-1-methyl-4-[[(1R)-1-methylpropyl]sulfamoyl]pyrrole-2-carboxylate (354 mg) as a white powder.", "1H NMR (400 MHz, DMSO-d6) δ ppm 0.76 (t, J=7.4 Hz, 3H), 0.98 (d, J=6.6 Hz, 3H), 1.28 (t, J=7.0 Hz, 3H), 1.31-1.40 (m, 2H), 3.01-3.18 (m, 1H), 3.81 (s, 3H), 4.27 (q, J=7.2 Hz, 2H), 7.47-7.57 (m, 2H).", "To ethyl 3-fluoro-1-methyl-4-[[(1R)-1-methylpropyl]sulfamoyl]pyrrole-2-carboxylate (354 mg, 1.156 mmol) and 5-amino-2-fluoro-benzonitrile (201.7 mg, 1.483 mmol) in dry THF (20 mL) at 0° C., lithium bis(trimethylsilyl)amide in THF (4.62 mL, 4.62 mmol) was added.", "The mixture was stirred 1 hour at 0° C. The reaction mixture was quenched with NH4Cl solution (30 mL) and extracted with EtOAc (50 mL), diluted with brine (50 mL) and extracted again with EtOAc (50 mL).", "The combine organic layers were dried over sodium sulphate, filtered and concentrated.", "The residue (dissolved in 1 mL DMF) was purified by column chromatography on silica using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated and the solid residue was crystallized from 50 mL warm methanol upon addition of water.", "The white crystals were filtered off and dried in vacuo at 50° C. overnight, resulting in compound 186 (306 mg) Method A: Rt: 1.83 min m/z: 395.1 (M−H)− Exact mass: 396.11.1H NMR (400 MHz, DMSO-d6) δ ppm 0.78 (t, J=7.4 Hz, 3H), 1.01 (d, J=6.6 Hz, 3H), 1.31-1.44 (m, 2H), 3.06-3.20 (m, 1H), 3.80 (s, 3H), 7.47 (d, J=4.6 Hz, 1H), 7.50-7.58 (m, 2H), 7.96 (ddd, J=9.2, 4.8, 2.9 Hz, 1H), 8.17 (dd, J=5.7, 2.6 Hz, 1H), 10.31 (s, 1H).", "Compound 187: N-(3-Cyano-4-fluorophenyl)-4-[(3,3-difluoro-1-methylcyclobutyl)sulfamoyl]-3-fluoro-1-methyl-1H-pyrrole-2-carboxamide Compound 187 (290 mg) was prepared similarly as described for compound 186 using 3,3-difluoro-1-methyl-cyclobutanamine hydrochloride (509.4 mg, 3.232 mmol) instead of (R)-(−)-2-aminobutane resulting in a white powder.", "Method A: Rt: 1.84 min m/z: 443.1 (M−H)− Exact mass: 444.09.1H NMR (400 MHz, DMSO-d6) δ ppm 1.42 (s, 3H), 2.47-2.62 (m, 2H), 2.80-2.97 (m, 2H), 3.81 (s, 3H), 7.49-7.58 (m, 2H), 7.96 (ddd, J=9.2, 5.0, 2.8 Hz, 1H), 8.16 (dd, J=5.7, 2.6 Hz, 1H), 8.22 (s, 1H), 10.33 (s, 1H).", "Compound 188: N-(3-Cyano-4-fluorophenyl)-3-fluoro-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 188 (409 mg) was prepared similarly as described for compound 186 using (2S)-1,1,1-trifluoropropan-2-amine instead of (R)-(−)-2-aminobutane resulting in a white powder.", "Method A: Rt: 1.89 min m/z: 435.0 (M−H)− Exact mass: 436.06.1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (d, J=7.0 Hz, 3H), 3.81 (s, 3H), 3.92-4.05 (m, 1H), 7.50-7.59 (m, 2H), 7.96 (ddd, J=9.2, 4.9, 2.9 Hz, 1H), 8.17 (dd, J=5.7, 2.6 Hz, 1H), 8.62 (d, J=8.8 Hz, 1H), 10.36 (s, 1H).", "Differential scanning calorimetry: peak at 190.92° C. Compound 189: N-(3-Chloro-4,5-difluorophenyl)-1-methyl-4-{[1-(trifluoromethyl)-cyclobutyl]sulfamoyl}-1H-pyrrole-2-carboxamide 5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (470.2 mg, 0.966 mmol) 1-trifluoromethyl)cyclobutan-1-amine (268.7 mg, 1.932 mmol DIPEA (0.518 mL, 2.99 mmol) was dissolved in CH3CN and refluxed over weekend.", "The reaction mixture was concentrated.", "The residue was dissolved in EtOAc (100 mL), washed with 1M HCl, dried over sodium sulphate, filtered and concentrated.", "The residue was purified by column chromatography on a silica using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated yielding a beige powder.", "This powder was repurified by Prep HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm), Mobile phase: 0.25% NH4HCO3 solution in water, CH3CN), yielding a white powder which was dried in vacuo at 50° C., resulting in compound 189 (32.9 mg).", "Method B: Rt: 1.18 min m/z: 470.0 (M−H)− Exact mass: 471.04.1H NMR (400 MHz, DMSO-d6) δ ppm 1.71-1.87 (m, 2H), 2.24-2.36 (m, 2H), 2.39-2.48 (m, 2H), 3.93 (s, 3H), 7.37 (d, J=2.0 Hz, 1H), 7.64 (d, J=1.8 Hz, 1H), 7.76-7.87 (m, 2H), 8.37 (s, 1H), 10.33 (s, 1H).", "Compound 190: 4-(tert-Butylsulfamoyl)-N-(3-cyano-4-fluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide methyl 4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate (5 g, 1.04 mmol) was dissolved in acetonitrile (100 mL).", "To this was added diisopropylethylamine (9.06 mL, 52.6 mmol) followed by Tert-Butylamine (3.23 g, 44.2 mmol) and the resulting mixture was refluxed for 2 hours.", "Then the mixture was cooled to room temperature and concentrated in vacuo.", "The resulting residue was dissolved in dichloromethane (250 mL) and was washed with HCl (2×150 mL).", "The organics were dried on sodium sulphate, filtered and concentrated in vacuo yielding a powder of methyl 4-(tert-butylsulfamoyl)-1-methyl-pyrrole-2-carboxylate which was used as such (6.07 g) Method B: Rt: 1.52 min m/z: 273.0 (M−H)− Exact mass: 274.10.1H NMR (360 MHz, DMSO-d6) δ ppm 1.13 (s, 9H), 3.77 (s, 3H), 3.88 (s, 3H) 7.00 (d, J=1.8 Hz, 1H), 7.18 (s, 1H), 7.60 (d, J=2.2 Hz, 1H).", "methyl 4-(tert-butylsulfamoyl)-1-methyl-pyrrole-2-carboxylate (11.269 g, 41.077 mmol) was dissolved in THF (120 mL).", "To this was added lithium hydroxide (1.476 g, 1.5 eq) in distilled water (16 mL) and a turbid mixture was obtained.", "Then MeOH (6 mL) was added and the mixture became clear.", "The resulting mixture was stirred for 18 hours.", "Then it was concentrated until water remained and distilled water (30 mL) was added.", "The mixture was neutralized using an exact amount of hydrochloric acid (1M/aq/61.6 mL, 61.62 mmol).", "The resulting mixture was extracted using 2-methyltetrahydrofuran.", "The combined extracts were dried on MgSO4, filtered and concentrated under reduced pressure resulting in 4-(tert-butylsulfamoyl)-1-methyl-pyrrole-2-carboxylic acid as a white powder which was used without further purifications for the next step (10.62 g).", "Method B: Rt: 0.83 min m/z: 258.9 (M−H)− Exact mass: 260.08.Compound 190 (2140 mg) was prepared similarly as described for compound 158 using 5-amino-2-fluorobenzonitrile (1348 mg, 9.604 mmol) and 4-(tert-butylsulfamoyl)-1-methyl-pyrrole-2-carboxylic acid and stirring at 50° C. instead of room temperature, resulting in a white solid.", "Method B: Rt: 0.96 min m/z: 377.1 (M−H)− Exact mass: 378.12.1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (s, 9H) 3.91 (s, 3H) 7.14 (s, 1H) 7.34 (d, J=1.76 Hz, 1H) 7.48-7.56 (m, 2H) 7.98-8.05 (m, 1H) 8.22 (dd, J=5.83, 2.75 Hz, 1H) 10.34 (s, 1H).", "Compound 191: 4-(tert-Butylsulfamoyl)-N-(3-cyanophenyl)-1-methyl-1H-pyrrole-2-carboxamide Compound 191 (758 mg) was prepared similarly as described for compound 190 using 3-aminobenzonitrile (458.4 mg, 3.84 mmol) instead of 5-amino-2-fluorobenzonitrile resulting in a white solid.", "Method B: Rt: 0.92 min m/z: 359.1 (M−H)− Exact mass: 360.13.1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (s, 9H) 3.92 (s, 3H) 7.13 (s, 1H) 7.36 (s, 1H) 7.51-7.59 (m, 3H) 7.99 (d, J=7.04 Hz, 1H) 8.19 (s, 1H) 10.31 (s, 1H).", "Compound 192: 4-(tert-Butylsulfamoyl)-N-(3-cyano-2-fluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide Compound 192 (733 mg) was prepared similarly as described for compound 190 using 3-amino-2-fluorobenzonitrile (522.9 mg, 3.842 mmol) instead of 5-amino-2-fluorobenzonitrile resulting in a white solid.", "Method B: Rt: 0.90 min m/z: 377.1 (M−H)− Exact mass: 378.12.1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (s, 9H) 3.89 (s, 3H) 7.15 (s, 1H) 7.34 (d, J=2.0 Hz, 1H) 7.42 (t, J=7.9 Hz, 1H) 7.55 (d, J=1.76 Hz, 1H) 7.77 (ddd, J=7.7, 5.9, 1.8 Hz, 1H) 7.90 (td, J=7.90, 1.5 Hz, 1H) 10.23 (s, 1H).", "Compound 193: 4-(tert-Butylsulfamoyl)-N-(3-chloro-2-fluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide Compound 193 (787 mg) was prepared similarly as described compound 190 using 3-chloro-2-fluoroaniline (0.435 mL, 3.84 mmol) resulting in a white solid.", "Method B: Rt: 1.02 min m/z: 386.1 (M−H)− Exact mass: 387.08.1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (s, 9H) 3.89 (s, 3H) 7.14 (s, 1H) 7.20-7.26 (m, 1H) 7.32 (d, J=1.76 Hz, 1H) 7.41-7.46 (m, 1H) 7.48-7.54 (m, 2H) 10.10 (s, 1H).", "Compound 194: 4-(tert-Butylsulfamoyl)-N-(3-chloro-2,4-difluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide Compound 194 (708 mg) was prepared similarly as described for compound 190 using 3-chloro-2,4-difluoroaniline (628.3, 3.84 mmol) resulting in a white solid.", "Method B: Rt: 1.03 min m/z: 404.1 (M−H)− Exact mass: 405.07.1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (s, 9H) 3.89 (s, 3H) 7.15 (s, 1H) 7.30-7.37 (m, 2H) 7.48-7.58 (m, 2H) 10.11 (s, 1H).", "Compound 195: 4-(tert-Butylsulfamoyl)-N-(3-chloro-4-fluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide Compound 195 (705 mg) was prepared similarly as described for compound 190 using 3-chloro-4-fluoroaniline (559.2 mg, 3.842 mmol) resulting in a white solid.", "Method A: Rt: 1.95 min m/z: 386.0 (M−H)− Exact mass: 387.08.1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (s, 9H), 3.91 (s, 3H), 7.12 (s, 1H), 7.32 (d, J=2.0 Hz, 1H), 7.39 (t, J=9.1 Hz, 1H), 7.53 (d, J=1.8 Hz, 1H), 7.63-7.70 (m, 1H), 8.02 (dd, J=6.8, 2.6 Hz, 1H), 10.19 (s, 1H).", "Compound 196: N-(3-Cyano-2,4-difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Methyl 1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (0.7 g, 2.23 mmol) was dissolved in THF (10 mL) under nitrogen.", "To this was added 3-amino-2,6-difluorobenzonitrile (0.45 g, 2.9 mmol) and the mixture was cooled in an ice-water bath while stirred under nitrogen.", "To this was added drop wise lithium bis(trimethylsilyl)amide 1M in toluene (6.68 mL, 6.68 mmol) over a period of 10 minutes.", "The resulting mixture was stirred for 1 hour while cooling was continued.", "The mixture was quenched with saturated ammonium chloride (25 mL) and the resulting mixture was extracted using EtOAc (3×25 mL).", "The combined extracts were washed with brine (20 mL), dried on Na2SO4, filtered and concentrated in vacuo.", "The obtained residue was dissolved in 2 mL dichloromethane and this was loaded on a dry silica plug.", "This was purified by column chromatography using gradient elution from heptane to EtOAc.", "(100:0 to 0:100).", "The desired fractions were collected and concentrated in vacuo yielding a powder.", "This powder was recrystallized out of MeOH/water.", "The obtained crystals were collected on a filter, rinsed with water followed by diisopropylether and dried in a vacuo at 55° C. for 24 hours resulting in N-(3-Cyano-2,4-difluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide (563 mg) as a powder.", "Method A: Rt: 1.75 min m/z: 435.0 (M−H)− Exact mass: 436.06.1H NMR (400 MHz, DMSO-d6) δ ppm 1.09 (d, J=6.8 Hz, 3H), 3.80-4.06 (m, 4H), 7.36 (d, J=2.0 Hz, 1H), 7.40-7.51 (m, 1H), 7.66 (d, J=1.5 Hz, 1H), 7.85-8.02 (m, 1H), 8.54 (br.", "s, 1H), 10.14 (br.", "s, 1H).", "Compound 197: N-(3-Cyanophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]-sulfamoyl}-1H-pyrrole-2-carboxamide Compound 197 (697.6 mg) was prepared similarly as described for compound 196 using 3-aminobenzonitrile (342 mg, 2.895 mmol) instead of 3-amino-2,6-difluorobenzonitrile resulting in N-(3-cyanophenyl)-1-methyl-4-[[(1S)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide as a solid.", "Method B: Rt: 0.93 min m/z: 399.1 (M−H)− Exact mass: 400.08.1H NMR (400 MHz, DMSO-d6) δ ppm 1.08 (d, J=6.8 Hz, 3H) 3.93 (s, 4H) 7.39 (d, J=1.9 Hz, 1H) 7.52-7.60 (m, 2H) 7.65 (d, J=1.9 Hz, 1H) 7.99 (dt, J=6.9, 2.3 Hz, 1H) 8.20 (br.", "s, 1H) 8.17-8.20 (m, 1H) 10.35 (br.", "s., 1H).", "Compound 198: N-(3-Cyano-2-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 198 (691 mg) was prepared similarly as described for compound 196 using 3-amino-2-fluoro-benzonitrile (394 mg, 2.895 mmol) instead of 3-amino-2,6-difluorobenzonitrile resulting in as a solid.", "Method B: Rt: 0.91 min m/z: 417.1 (M−H)− Exact mass: 418.07.1H NMR (400 MHz, DMSO-d6) δ ppm 1.03-1.18 (m, 3H), 3.84-4.03 (m, 4H), 7.38 (d, J=2.0 Hz, 1H), 7.42 (t, J=7.9 Hz, 1H), 7.66 (d, J=1.8 Hz, 1H), 7.77 (ddd, J=7.6, 6.0, 1.5 Hz, 1H), 7.91 (td, J=7.8, 1.5 Hz, 1H), 7.99-9.14 (m, 1H), 10.26 (br.", "s., 1H).", "Compound 199: 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Sodium hydride (3.46 g, 90.2 mmol, 60% dispersion in oil) was added portion wise, over a period of 10 minutes, to a solution of methyl 3-chloro-1H-pyrrole-2-carboxylate (12 g, 75.2 mmol), iodomethane (12.8 g, 90.2 mmol) and DMF (120 mL) at 0° C. under nitrogen in an ice bath.", "The ice bath was removed and the reaction mixture was stirred 3 hours at room temperature.", "The reaction mixture was acidified with aqueous hydrochloric acid (15.04 mL, 1 M) and concentrated.", "The residue was dissolved in water (100 mL)/ethyl acetate (300 mL).", "The organic layer was dried over Na2SO4, filtered and concentrated.", "The residue was dissolved in acetonitrile (150 mL), washed with heptane (100 mL) and concentrated at 70° C. yielding methyl 3-chloro-1-methyl-pyrrole-2-carboxylate (12.0 g) as yellow liquid which was used as such.", "1H NMR (400 MHz, CHLOROFORM-d) δ ppm 3.87 (s, 3H), 3.88 (s, 3H), 6.13 (d, J=2.9 Hz, 1H), 6.69 (d, J=2.9 Hz, 1H) Methyl 3-chloro-1-methyl-pyrrole-2-carboxylate (5.0 g, 25.1 mmol) was added drop wise to chlorosulfonic acid (11 mL) at 0° C. under nitrogen atmosphere.", "The reaction mixture was warmed to room temperature and allowed to stir 2 hours.", "The resulting mixture was added drop wise to a stirred, temperature controlled ice-water mixture (200 mL) keeping the temperature under 5° C. A white precipitation was formed.", "The obtained aqueous suspension was extracted using dichloromethane (3×100 mL).", "The combined organic extracts were washed with Brine and dried on sodium sulphate, filtered and concentrated in vacuo yielding methyl 3-chloro-4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate (5.56 g) as light green powder which was used as such.", "1H NMR (400 MHz, CHLOROFORM-d) δ ppm 3.94 (s, 3H), 3.98 (s, 3H), 7.46 (s, 1H).", "In a microwave tube methyl 3-chloro-4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate (1.5 g, 5.51 mmol) was dissolved in acetonitrile (10 mL).", "To this was added DIPEA (1.42 mL, 0.75 g/mL, 8.27 mmol) followed by (R)-1,1,1-trifluoro-2-propylamine (0.94 g, 8.27 mmol) and molecular sieves and the tube was closed and resulting mixture was heated at 80° C. 30 minutes under microwave irradiation.", "The reaction mixture was concentrated and the resulting brown sticky oil was dissolved in dichloromethane (50 mL) and this was washed with HCl (1N, 2×10 mL) and Brine (5 mL) and dried on sodium sulphate.", "The solids were filtered off and the filtrate was concentrated in vacuo yielding brown oil.", "The brown oil was purified using silica gel column chromatography (ethyl acetate in heptane from 0 to 100%) to afford methyl 3-chloro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (660 mg) as white powder which was used as such.", "Method B: Rt: 0.88 min m/z: 347 (M−H)− Exact mass: 348.02.1H NMR (400 MHz, DMSO-d6) δ ppm 1.15 (d, J=7.0 Hz, 3H), 3.83 (s, 3H), 3.86 (s, 3H), 3.89-4.02 (m, 1H), 7.76 (s, 1H), 8.51 (d, J=8.8 Hz, 1H).", "Methyl 3-chloro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (660 mg, 1.89 mmol) and 5-amino-2-fluorobenzonitrile (332 mg, 2.37 mmol) were dissolved in dry tetrahydrofuran (30 mL) under nitrogen.", "The reaction mixture was cooled to 0° C. and lithium bis(trimethylsilyl)amide in tetrahydrofuran (5.46 mL, 5.46 mmol, 1M) was added over a period of 2 minutes.", "The resulting mixture was stirred for 2 minutes while cooling was continued.", "The mixture was quenched with saturated aqueous ammonium chloride (15 mL) and the resulting mixture was extracted using ethyl acetate (3×30 mL).", "The combined extracts were washed with Brine (10 mL), dried on Na2SO4, filtered and concentrated in vacuo to afford a red powder.", "The obtained residue was triturated in a refluxing mixture of CH2Cl2/EtOAc/methanol (10/5/5 mL).", "The solids were filtered to afford a dark pink powder which was recrystallized from methanol/water (7/0.5 mL) to afford compound 199 as a powder (325 mg) Method B: Rt: 0.99 min m/z: 451.0 (M−H)− Exact mass: 452.03.1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=6.8 Hz, 3H), 3.78 (s, 3H), 3.91-4.05 (m, 1H), 7.56 (t, J=9.1 Hz, 1H), 7.69 (s, 1H), 7.98 (ddd, J=9.2, 4.8, 2.8 Hz, 1H), 8.19 (dd, J=5.8, 2.8 Hz, 1H), 8.51 (d, J=8.8 Hz, 1H), 10.68 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 190.1° C. Alternative Procedure for the Synthesis of methyl 3-chloro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate Methyl 3-chloro-4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate (1 g, 3.68 mmol) was dissolved in hot acetonitrile (5 mL), molecular sieves (about 100 mg) were added and the reaction mixture was stirred.", "In a separate vessel (R)-1,1,1-trifluoro-2-propylamine (623 mg, 5.51 mmol) was dissolved in acetonitrile (5 mL), molecular sieves (about 100 mg) was added.", "This suspension was added to the reaction mixture and then NaHCO3 (926 mg, 11.0 mmol) was added.", "The vessel was closed and it was stirred overnight at 80° C. The volatiles were removed under reduced pressure and the obtained residue was purified by silica gel chromatography, using a gradient from heptane to EtOAc, yielding methyl 3-chloro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (1.04 g) as a white powder.", "Compound 200: N-(3-Cyano-4-fluorophenyl)-4-{[2,2-difluoro-1-methylethyl]sulfamoyl}-1-methyl-1H-pyrrole-2-carboxamide 5-amino-2-fluoro-benzonitrile (5.62 g, 41.3 mmol) was added to a solution of 4-chlorosulfonyl-1-methyl-pyrrole-2-carbonyl chloride (described in the synthesis of compound 3) (10 g, 41.3 mmol), toluene (300 mL) at reflux.", "The reaction mixture was refluxed 4 hours and filtered warm.", "The filtrate was concentrated to dryness to afford a yellow powder which was dried over weekend in vacuo.", "The yellow powder was triturated in warm ethyl acetate (50 mL) and filtered and washed with dichloromethane.", "The filtrate was concentrated to dryness and the residue was purified using silica gel column chromatography (ethyl acetate in heptane from 0 to 100%) to afford 5-[(3-cyano-4-fluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (5.05 g) as off white powder.", "5-[(3-cyano-4-fluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (1.00 g, 2.93 mmol) was dissolved in a solution of 1,1-difluoropropan-2-amine (417 mg, 4.39 mmol, synthesized according of PCT Int.", "Appl., 2012049277) in THF (17 mL) dried on molecular sieves and stirred at 60° C. for 20 hours.", "The reaction mixture was filtered and the filtrate was evaporated to dryness.", "The residue was purified using silica gel column chromatography (ethyl acetate in heptane from 10 to 70%) to afford crude compound 200 as white powder.", "Compound 200 was purified by Prep SFC (Stationary phase: Chiralpak Diacel AD 20×250 mm), Mobile phase: CO2, methanol with 0.2% iPrNH2), the desired fractions were collected, evaporated, solved in methanol and evaporated again, yielding compound 200 a (192 mg) as white powder.", "Method A: Rt: 1.67 min m/z: 399.1 (M−H)− Exact mass: 400.08 1H NMR (400 MHz, DMSO-d6) δ ppm 0.99 (d, J=7.0 Hz, 3H), 3.42-3.56 (m, 1H), 3.93 (s, 3H), 5.90 (td, J=56.1, 2.6 Hz, 1H), 7.36 (d, J=2.0 Hz, 1H), 7.53 (t, J=9.2 Hz, 1H), 7.64 (d, J=1.8 Hz, 1H), 7.83 (br.", "s., 1H), 8.01 (ddd, J=9.2, 4.8, 2.6 Hz, 1H), 8.21 (dd, J=5.7, 2.6 Hz, 1H), 10.37 (s, 1H).", "And compound 200b (190 mg) as white powder.", "Method A: Rt: 1.67 min m/z: 399.0 (M−H)− Exact mass: 400.08.1H NMR (400 MHz, DMSO-d6) δ ppm 0.99 (d, J=7.0 Hz, 3H), 3.42-3.57 (m, 1H), 3.93 (s, 3H), 5.90 (td, J=56.1, 2.6 Hz, 1H), 7.36 (d, J=1.8 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.64 (d, J=1.8 Hz, 1H), 7.77 (br.", "s., 1H), 8.01 (ddd, J=9.2, 4.9, 2.9 Hz, 1H), 8.21 (dd, J=5.9, 2.6 Hz, 1H), 10.37 (br.", "s., 1H).", "Compound 201: N-(3-Chloro-4,5-difluorophenyl)-1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 201 (69 mg) as white powder was prepared similarly as described for compound 179 using 3-chloro-4,5-difluoro-aniline (0.18 g, 1.08 mmol) instead of 4-fluoro-3-(trifluoromethyl)aniline.", "The reaction was stirred at 50° C. for 92 hours.", "Method B: Rt: 0.98 min m/z: 432.1 (M−H)− Exact mass: 433.07.1H NMR (400 MHz, DMSO-d6) δ ppm 1.53 (s, 3H), 2.32 (s, 3H), 3.72 (s, 3H), 4.12 (d, J=6.4 Hz, 2H), 4.61 (d, J=5.9 Hz, 2H), 7.49 (s, 1H), 7.71-7.81 (m, 2H), 7.93 (br.", "s., 1H), 10.40 (br.", "s., 1H).", "Compound 243: N-(3-Chloro-2,4-difluorophenyl)-1,3-dimethyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide 1,3-dimethyl-4-(N-(3-methyloxetan-3-yl)sulfamoyl)-1H-pyrrole-2-carboxylic acid (500 mg, 1.73 mmol), 3-chloro-2,4-difluoroaniline (0.57 g, 3.47 mmol) and HATU (0.88 g, 2.31 mmol) were dissolved in DMF (2 mL) containing DIPEA (0.69 mL, 3.98 mmol).", "The reaction mixture was stirred at 65° C. for 28 hours and at room temperature for 60 hours.", "The reaction mixture was purified using silica gel column chromatography (ethyl acetate in heptane from 10 to 70%).", "The desired fractions were combined and evaporated to afford a light brown oil which solidified while standing.", "The solid was recrystallized from ethanol (5 mL) to afford a white solid which was filtered and washed with ethanol (1 mL).", "The white solid was dried overnight in vacuo, resulting in compound 243 (318 mg) as off white solid.", "Method D: Rt: 1.73 min m/z: 432.0 (M−H)− Exact mass: 433.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.52 (s, 3H), 2.37 (s, 3H), 3.73 (s, 3H), 4.11 (d, J=6.4 Hz, 2H), 4.61 (d, J=5.9 Hz, 2H), 7.35 (td, J=9.0, 2.0 Hz, 1H), 7.47 (s, 1H), 7.67 (td, J=8.7, 5.8 Hz, 1H), 7.91 (br.", "s., 1H), 10.03 (br.", "s., 1H).", "Compound 202: N-(3-Chloro-4,5-difluorophenyl)-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 202 was prepared similarly as described for compound 144.In Step 4, 1,3-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid (260 mg, 0.83 mmol) was used and 3-chloro-4,5-difluoro-aniline (0.27 g, 1.65 mmol) instead of 3,4-difluoroaniline was used.", "This reaction was performed at 50° C. for 92 hours.", "The desired fractions were combined and evaporated to afford a powder which was recrystallized from CH2Cl2.The white crystals were filtered and washed with CH2Cl2 and dried overnight in vacuum oven at 50° C. to afford a white solid (170 mg).", "Method B: Rt: 1.12 min m/z: 458.0 (M−H)− Exact mass: 459.04.1H NMR (400 MHz, DMSO-d6) δ ppm 1.11 (d, J=6.8 Hz, 3H), 2.30 (s, 3H), 3.72 (s, 3H), 3.78-3.90 (m, 1H), 7.53 (s, 1H), 7.66-7.84 (m, 2H), 8.18 (br.", "s., 1H), 10.39 (s, 1H).", "Compound 203: N-(2,3-Difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Into a 100 mL round bottom flask equipped with a magnetic stir bar was placed methyl 1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (0.9 g, 2.86 mmol), anhydrous THF (40 mL), and 2,3-difluoroaniline (490 mg, 3.72 mmol).", "The vial was sealed and placed into an ice-water bath and to it was added LHMDS (8.6 mL of a 1M solution in THF/ethylbenzene) slowly via syringe (approx rate of 2 mL/min).", "Conversion to product seen after 30 min at 0° C. Sat.", "aq.", "ammonium chloride was added to quench the reaction.", "This was diluted with ethyl acetate (100 mL) and the mixture partitioned with ethyl acetate (3×100 mL).", "The organic layers were combined, dried (magnesium sulfate), the solids were removed by filtration and the solvents of the filtrate were removed under reduced pressure.", "The crude was partially purified via silica column chromatography using a heptane to ethylacetate gradient.", "The solvent of the best fractions were removed under reduced pressure and the compound was recrystallized from ether/heptane to afford compound 203 as a white solid (395 mg).", "Method A: Rt: 1.75 min m/z: 410.1 (M−H)− Exact mass: 411.07.1H NMR (400 MHz, DMSO-d6) δ ppm 1.10 (d, J=7.0 Hz, 3H), 3.85-4.00 (m, 1H), 3.91 (s, 3H), 7.16-7.40 (m, 4H), 7.65 (d, J=1.8 Hz, 1H), 8.17 (d, J=7.7 Hz, 1H), 10.15 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 157.94° C. Compound 204: N-(3-Chloro-2,6-difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 204 was prepared similarly as described for compound 203 using 3-chloro-2,6-difluoro-aniline (627.7 mg, 3.72 mmol) and the crude was recrystallized in diisopropyl ether/heptane to afford a white solid (423 mg) Method A: Rt: 1.79 min m/z: 444.0 (M−H)− Exact mass: 445.03.1H NMR (400 MHz, DMSO-d6) δ ppm 1.12 (d, J=6.8 Hz, 3H), 3.84-4.01 (m, 1H), 3.91 (s, 3H), 7.31 (t, J=8.8 Hz, 1H), 7.41 (s, 1H), 7.57-7.66 (m, 1H), 7.69 (s, 1H), 8.21 (d, J=8.1 Hz, 1H), 10.17 (s, 1H).", "Compound 205: N-(3-Bromo-4,5-difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 205 (893 mg) was prepared similarly as described for compound 158 using 3-bromo-4,5-difluoroaniline (970 mg, 4.663 mmol) instead of 3-aminobenzonitrile and stirring at 60° C. during 18 h. The obtained residue was warmed with CH2Cl2/heptanes and the white solid collected by filtration.", "Method A: Rt: 1.79 min m/z: 489.9 (M−H)− Exact mass: 488.98.1H NMR (400 MHz, DMSO-d6) δ ppm 1.08 (d, J=7.0 Hz, 3H), 3.84-3.99 (m, 1H), 3.92 (s, 3H), 7.36 (d, J=1.8 Hz, 1H), 7.67 (d, J=1.5 Hz, 1H), 7.80-7.93 (m, 2H), 8.19 (br.", "s., 1H), 10.30 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 196.72° C. Compound 206: N-(3-Bromo-2-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 206 (637 mg) was prepared similarly as described for compound 158 using 3-bromo-2-fluoroaniline (886 mg, 4.663 mmol) instead of 3-aminobenzonitrile and stirring at 60° C. during 18 h. The residue was warmed with heptane, 1 drop EtOAc added precipitation occurs.", "A white solid was filtered off and dried in vacuo.", "Method A: Rt: 1.88 min m/z: 470.0 (M−H)− Exact mass: 470.99.1H NMR (400 MHz, DMSO-d6) δ ppm 1.09 (d, J=6.8 Hz, 3H), 3.85-4.00 (m, 1H), 3.90 (s, 3H), 7.18 (td, J=8.0, 1.3 Hz, 1H), 7.36 (d, J=2.0 Hz, 1H), 7.50-7.60 (m, 2H), 7.65 (d, J=1.8 Hz, 1H), 8.17 (br.", "s., 1H), 10.11 (br.", "s., 1H) Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 216.73° C. Compound 207: N-(3-chloro-4,5-difluoro-phenyl)-4-[(2-fluoro-1,1-dimethyl-ethyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide 5-[(3-chloro-4,5-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (212.7 mg, 0.437 mmol) [112433-52-0], 1-fluoro-2-methyl-propan-2-amine hydrochloride (69.7 mg, 0.546 mmol) and Et3N (0.152 mL, 1.09 mmol) was dissolved in CH3CN (35.4 mL, 678.73 mmol) stirred overnight and concentrated.", "The residue was dissolved in DMF (2 mL) and purified by column chromatography on silica using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated.", "The residue was crystallized from methanol (10 mL) upon addition of water.", "The white crystals of were filtered off and dried overnight in vacuo at 50° C., resulting in compound 207 (93 mg).", "Method A: Rt: 2.02 min m/z: 422.0 (M−H)− Exact mass: 423.06.1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (d, J=1.8 Hz, 6H), 3.91 (s, 3H), 4.23 (d, J=1.0 Hz, 2H), 7.34 (d, J=2.0 Hz, 1H), 7.42 (s, 1H), 7.58 (d, J=1.8 Hz, 1H), 7.76-7.86 (m, 2H), 10.29 (s, 1H).", "Compound 208: N-(3-Chloro-2,4-difluorophenyl)-1,3-dimethyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 208 was prepared from ethyl 4-[tert-butoxycarbonyl(isopropyl)sulfamoyl]-1,3-dimethyl-pyrrole-2-carboxylate and 3-chloro-2,4-difluoroaniline using LiHMDS in THF, followed by removal of the Boc-protection by treatment with HCl in iPrOH/CH2Cl2, resulting in compound 208 (266 mg).", "Method B: Rt: 1.02 min m/z: 404.1 (M−H)− Exact mass: 405.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.02 (d, J=6.6 Hz, 6H), 2.34 (s, 3H), 3.14-3.25 (m, 1H), 3.73 (s, 3H), 7.20 (d, J=7.5 Hz, 1H), 7.35 (td, J=9.0, 2.1 Hz, 1H), 7.44 (s, 1H), 7.66 (td, J=8.7, 5.8 Hz, 1H), 9.99 (s, 1H).", "Compound 209: N-(3-Chloro-2,4-difluorophenyl)-1,3-dimethyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 209 was prepared similarly as described for compound 146, using 3-chloro-2,4-difluoroaniline instead of 3,4-difluoroaniline.", "Compound 209 was recrystallized from EtOH, resulting in a white powder (211 mg).", "Method D: Rt: 1.97 min m/z: 458.0 (M−H)− Exact mass: 459.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.11 (d, J=6.8 Hz, 3H), 2.35 (s, 3H), 3.73 (s, 3H), 3.76-3.90 (m, 1H), 7.36 (td, J=9.0, 2.0 Hz, 1H), 7.52 (s, 1H), 7.66 (td, J=8.7, 5.8 Hz, 1H), 8.16 (br.", "d, J=7.3 Hz, 1H), 10.02 (s, 1H).", "Compound 210: N-(3-Chloro-2,4-difluorophenyl)-1,3-dimethyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 210 was prepared similarly as described for compound 144 using 3-chloro-2,4-difluoroaniline instead of 3,4-difluoroaniline.", "The obtained solid was recrystallized from ethanol (5 mL) to afford compound 210 (206 mg) as a white solid.", "Method D: Rt: 1.97 min m/z: 458.0 (M−H)− Exact mass: 459.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.11 (d, J=6.8 Hz, 3H), 2.35 (s, 3H), 3.73 (s, 3H), 3.76-3.89 (m, 1H), 7.36 (td, J=9.0, 2.0 Hz, 1H), 7.52 (s, 1H), 7.66 (td, J=8.7, 5.7 Hz, 1H), 8.16 (d, J=8.6 Hz, 1H), 10.02 (s, 1H).", "Compound 211: 4-(tert-Butylsulfamoyl)-N-(3,4-difluorophenyl)-3-fluoro-1-methyl-1H-pyrrole-2-carboxamide Compound 211 (516 mg, white crystals) was prepared similarly as described for compound 214, using 3,4-difluoroaniline instead of 5-amino-2-fluoro-benzonitrile.", "Method D: Rt: 1.96 min m/z: 388.1 (M−H)− Exact mass: 389.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.20 (s, 9H), 3.79 (s, 3H), 7.35-7.48 (m, 4H), 7.77-7.86 (m, 1H), 10.19 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at: 184.9° C. Compound 212: 4-(tert-Butylsulfamoyl)-N-(3-chloro-2,4-difluorophenyl)-3-fluoro-1-methyl-1H-pyrrole-2-carboxamide Compound 212 (396 mg, white crystals) was prepared similarly as described for compound 214, using 3-chloro-2,4-difluoro-aniline instead of 5-amino-2-fluoro-benzonitrile.", "Method D: Rt: 2.05 min m/z: 422.1 (M−H)− Exact mass: 423.1 1H NMR (400 MHz, DMSO-d6) δ ppm 1.20 (s, 9H), 3.80 (s, 3H), 7.34 (d, J=2.0 Hz, 1H), 7.45-7.50 (m, 2H), 7.60-7.70 (m, 1H), 9.80 (br.", "s., 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at: 230.3° C. Compound 213: 4-(tert-Butylsulfamoyl)-3-fluoro-1-methyl-N-(2,3,4-trifluorophenyl)-1H-pyrrole-2-carboxamide Compound 213 (25 mg, white crystals) was prepared similarly as described for compound 214, using 2,3,4-trifluoroaniline instead of 5-amino-2-fluoro-benzonitrile.", "Method D: Rt: 1.97 min m/z: 406.1 (M−H)− Exact mass: 407.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.20 (s, 9H), 3.80 (s, 3H), 7.27-7.39 (m, 1H), 7.41-7.51 (m, 3H), 9.85 (br.", "s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at: 223.3° C. Compound 214: 4-(tert-Butylsulfamoyl)-N-(3-cyano-4-fluorophenyl)-3-fluoro-1-methyl-1H-pyrrole-2-carboxamide A mixture of ethyl 4-chlorosulfonyl-3-fluoro-1-methyl-pyrrole-2-carboxylate (purified by column chromatography with 10 to 50% EtOAc in heptane, 1.50 g, 5.6 mmol), tert-butylamine (934 mg, 12.8 mmol) and acetonitrile (75 mL) was stirred 2 hours and then concentrated.", "The residue was dissolved in EtOAc (150 mL) washed with water, dried over sodium sulphate, filtered and concentrated yielding ethyl 4-(tert-butylsulfamoyl)-3-fluoro-1-methyl-pyrrole-2-carboxylate (1.65 g) as light yellow crystals.", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (s, 9H), 1.28 (t, J=7.0 Hz, 3H), 3.82 (s, 3H), 4.27 (q, J=7.1 Hz, 2H), 7.45 (s, 1H), 7.51 (d, J=4.8 Hz, 1H).", "Method D: Rt: 1.79 min m/z: 305.1 (M−H)− Exact mass: 306.1.A mixture of ethyl 4-(tert-butylsulfamoyl)-3-fluoro-1-methyl-pyrrole-2-carboxylate (1.65 g, 5.4 mmol), lithium hydroxide (386 mg, 16.1 mmol), THF (20 mL) and water (5 mL) was stirred overnight.", "The reaction mixture was concentrated and the obtained residue was dissolved in water (50 mL) and neutralised with HCl (1M in H2O).", "The formed white crystals were filtered off and dried in vacuo at 50° C. during 4 hours, resulting in 4-(tert-butylsulfamoyl)-3-fluoro-1-methyl-pyrrole-2-carboxylic acid (1.1 g).", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.16 (s, 9H), 3.81 (s, 3H), 7.42 (s, 1H), 7.46 (d, J=4.8 Hz, 1H), 13.02 (br.", "s, 1H) Method B: Rt: 0.43 min m/z: 277.1 (M−H)− Exact mass: 278.1.4-(tert-butylsulfamoyl)-3-fluoro-1-methyl-pyrrole-2-carboxylic acid (100 mg, 0.359 mmol), HATU (170.781 mg, 0.449 mmol), Et3N (0.15 mL, 0.728 g/mL, 1.078 mmol), 5-amino-2-fluoro-benzonitrile (97.8 mg, 0.72 mmol) in DMF (1 mL) was stirred overnight at 65° C. The solution was cooled to room temperature and, as such, subjected to silica gel (120 g) column chromatography using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated and the obtained residue was dissolved in warm methanol (10 mL).", "Water was added until crystallisation began.", "The crystals were filtered off and dried overnight in vacuo at 50° C., resulting in compound 214 (94 mg).", "Method D: Rt: 1.87 min m/z: 395.1 (M−H)− Exact mass: 396.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.20 (s, 9H), 3.80 (s, 3H), 7.44-7.49 (m, 2H), 7.53 (t, J=9.1 Hz, 1H), 7.92-8.00 (m, 1H), 8.17 (dd, J=5.7, 2.6 Hz, 1H), 10.29 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at: 198.3° C. Compound 215: N-(3-Chloro-2,4-difluorophenyl)-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 215 (94 mg, white solid) was prepared from 3-chloro-2,4-difluoro-aniline and 3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxylic acid similarly as described for the synthesis of compound 214 from 5-amino-2-fluoro-benzonitrile and 4-(tert-butylsulfamoyl)-3-fluoro-1-methyl-pyrrole-2-carboxylic acid.", "Method D: Rt: 1.80 min m/z: 436.1 (M−H)− Exact mass: 437.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.56 (s, 3H), 3.81 (s, 3H), 4.18 (d, J=6.4 Hz, 2H), 4.65 (d, J=6.2 Hz, 2H), 7.35 (td, J=9.0, 2.0 Hz, 1H), 7.53 (d, J=4.4 Hz, 1H), 7.64 (td, J=8.7, 5.8 Hz, 1H), 8.32 (s, 1H), 9.87 (s, 1H).", "Compound 216: 3-Cyano-N-(3-cyano-4-fluorophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 171 (60 mg, 0.16 mmol) and potassium cyanide (102 mg, 1.6 mmol) were dissolved in acetonitrile (2 mL, 38.3 mmol) and heated at 130° C. for 8.5 hours by microwave irradiation.", "The reaction mixture was filtered, decalite was added to the filtrate and the suspension was evaporated to dryness.", "The solid was purified using silica gel column chromatography (ethyl acetate in heptane from 10 to 100%) to afford compound 216 as a yellow powder.", "Method B: Rt: 0.90 min m/z: 388.1 (M−H)− Exact mass: 389.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.07 (d, J=6.4 Hz, 6H), 3.35-3.46 (m, 1H), 3.85 (s, 3H), 7.58 (t, J=9.1 Hz, 1H), 7.72 (s, 1H), 7.74 (br.", "s., 1H), 7.94 (ddd, J=9.1, 4.8, 2.8 Hz, 1H), 8.18 (dd, J=5.7, 2.6 Hz, 1H), 11.15 (br.", "s., 1H).", "Compound 217: 3-Chloro-N-(3,4-difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Methyl 3-chloro-4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate (4 g, 14.7 mmol) was dispensed in acetonitrile (20 mL), (R)-1,1,1-trifluoro-2-propylamine (2493 mg, 22.1 mmol), Hunig's base (3.8 mL, 22.1 mmol) and molecular sieves (100 mg) were added and the reaction mixture was heated overnight at 80° C. The reaction mixture was cooled down, filtered and evaporated to dryness.", "The obtained residue was purified by silica gel column chromatography using a heptane to EtOAc gradient yielding methyl 3-chloro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (1.76 g) as a white powder.", "Methyl 3-chloro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (590 mg, 1.69 mmol) and 3,4-difluoroaniline (286 mg, 2.2 mmol) were dissolved in THF (10 mL) and cooled to 0° C. Lithium bis(trimethylsilyl)amide (1M in THF), 5.08 mL, 1 M, 5.08 mmol) was added and the reaction mixture was allowed to reach room temperature.", "The volatiles were removed under reduced pressure to keep +/−5 mL.", "The residue was partitioned between CH2Cl2 and water.", "The water layer was neutralised using aqueous hydrochloric acid (1M) to form a white precipitate.", "The white solids were filtered and washed with water.", "The organic layer was loaded on a silica gel cartridge and a gradient from heptane to EtOAc was applied.", "The desired fractions were evaporated to keep +/−50 mL.", "A white precipitate was formed.", "The white solid was filtered and washed with heptane to afford a second solid fraction.", "The two solids were combined and recrystallized from methanol (5 mL) to afford compound 217 (255 mg) as a white powder.", "The filtrate was concentrated to dryness and recrystallized from ethyl acetate (6 mL) heptane (20 mL) to afford more compound 217 (185 mg) as a white powder which was dried in vacuo.", "Method B: Rt: 1.06 min m/z: 444.1 (M−H)− Exact mass: 445.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=6.8 Hz, 3H), 3.77 (s, 3H), 3.89-4.06 (m, 1H), 7.38-7.50 (m, 2H), 7.66 (s, 1H), 7.78-7.91 (m, 1H), 8.49 (br.", "s., 1H), 10.56 (br.", "s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at: 203.9° C. (EtOAc/heptane).", "Compound 218: 3-Chloro-N-(3-chloro-2,4-difluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 218 was prepared similarly as described for the synthesis of compound 217 using 3-chloro-2,4-difluoro-aniline instead of 3,4-difluoroaniline.", "After partitioning between CH2Cl2 and water, the water layer was neutralised using aqueous hydrochloric acid (1M) to form a white precipitate.", "The water layer was extracted with CH2Cl2 (2×50 mL) and EtOAc (2×150 mL).", "The combined organic layers were washed with brine and dried (Na2SO4) and concentrated to dryness.", "The obtained brown powder was recrystallized from ethyl acetate (20 mL) resulting in compound 218 (576 mg) as a powder which was dried in vacuo.", "Method B: Rt: 1.13 min m/z: 478.0 (M−H)− Exact mass: 479.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=7.0 Hz, 3H), 3.79 (s, 3H), 3.90-4.05 (m, 1H), 7.37 (td, J=9.0, 2.0 Hz, 1H), 7.69 (s, 1H), 7.66-7.76 (m, 1H), 8.50 (br.", "s., 1H), 10.24 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 213.0° C. Compound 219: 3-Chloro-N-(3-chloro-2,4-difluorophenyl)-1-methyl-4-{[1-(trifluoro-methyl)cyclobutyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 219 (136 mg) was prepared similarly as described for the synthesis of compound 221 using 3-chloro-2,4-difluoro-aniline instead of 5-amino-2-fluorobenzonitrile.", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.75-1.87 (m, 2H), 2.24-2.35 (m, 2H), 2.41-2.47 (m, 2H), 3.80 (s, 3H), 7.37 (td, J=9.0, 2.1 Hz, 1H), 7.68 (s, 1H), 7.69-7.75 (m, 1H), 8.60 (br.", "s., 1H), 10.22 (s, 1H).", "Method D: Rt: 2.14 min m/z: 504.0 (M−H)− Exact mass: 505.0.Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 237.3° C. Compound 220: 4-(tert-Butylsulfamoyl)-3-chloro-N-(3-chloro-4-fluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide Compound 220 (614 mg) was prepared similarly as described for the synthesis of compound 226 using 3-chloro-4-fluoro-aniline instead of 5-amino-2-fluorobenzonitrile.", "Method D: Rt: 2.07 min m/z: 420.1 (M−H)− Exact mass: 421.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (s, 9H), 3.76 (s, 3H), 7.34 (s, 1H), 7.42 (t, J=9.1 Hz, 1H), 7.59 (s, 1H), 7.60-7.67 (m, 1H), 7.98 (dd, J=6.7, 2.5 Hz, 1H), 10.48 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 195.9° C. Compound 221: 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-{[1-(trifluoro-methyl)cyclobutyl]sulfamoyl}-1H-pyrrole-2-carboxamide Methyl 3-chloro-4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate (2000 mg, 7.35 mmol) was dispensed in acetonitrile (15 mL) in a microwave tube, 1-(trifluoromethyl)cyclobutan-1-amine (1.53 mg, 11.0 mmol) and Hunig's base (1.9 mL, 11.03 mmol) were added and the tube was sealed and heated at 85° C. for 8 hours.", "The solids were filtered off and the filtrate was evaporated to dryness.", "The residue was purified on silica gel using a heptane to EtOAc gradient yielding methyl 3-chloro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxylate as an off-white powder (382 mg).", "Methyl 3-chloro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxylate (150 mg, 0.4 mmol) and 5-amino-2-fluorobenzonitrile (0.52 mmol) were dissolved in dry THF and cooled to 0° C. Lithium bis(trimethylsilyl)amide (1.24 mL, 1 M in THF, 1.24 mmol) was added dropwise and the reaction mixture was allowed to reach room temperature.", "After 1 hour lithium bis(trimethyl-silyl)amide (0.5 mL, 1 M in THF, 0.5 mmol) was added and the reaction mixture was stirred for another hour.", "The volatiles were removed under reduced pressure and the residue was purified on silica gel using a heptane to EtOAc gradient.", "The collected fractions were evaporated to dryness and the residue was crystallized from a heptane/EtOAc mixture yielding compound 221 (91 mg) as off-white powder.", "Method D: Rt: 1.95 min m/z: 477.1 (M−H)− Exact mass: 478.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.75-1.88 (m, 2H), 2.25-2.37 (m, 2H), 2.41-2.48 (m, 2H), 3.79 (s, 3H), 7.56 (t, J=9.1 Hz, 1H), 7.68 (s, 1H), 7.99 (ddd, J=9.2, 4.8, 2.6 Hz, 1H), 8.20 (dd, J=5.7, 2.6 Hz, 1H), 8.61 (s, 1H), 10.67 (s, 1H).", "Compound 222: 3-Chloro-N-(3-chloro-4-fluorophenyl)-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 222 was prepared similarly as described for the synthesis of compound 217 using 3-chloro-4-fluoro-aniline instead of 3,4-difluoroaniline.", "After partitioning between CH2Cl2 and water, the water layer was neutralised using aqueous hydrochloric acid (1M) to form a white precipitate.", "The water layer was extracted with CH2Cl2 (4×50 mL).", "The combined organic layers were washed with brine and dried (Na2SO4) and concentrated to keep (15 mL).", "The white solid was filtered and washed with heptane to afford compound 222 (632 mg) as off white powder.", "Method B: Rt: 1.12 min m/z: 460.1 (M−H)− Exact mass: 461.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=6.8 Hz, 3H), 3.77 (s, 3H), 3.92-4.04 (m, 1H), 7.43 (t, J=9.0 Hz, 1H), 7.63 (ddd, J=9.0, 4.2, 2.6 Hz, 1H), 7.67 (s, 1H), 7.99 (dd, J=6.8, 2.6 Hz, 1H), 8.14 (br.", "s., 1H), 10.56 (br.", "s., 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 218.8° C. Compound 223: 4-(tert-Butylsulfamoyl)-3-chloro-N-(3,4-difluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide Compound 223 (579 mg) was prepared similarly as described for the synthesis of compound 226 using 3,4-difluoroaniline instead of 5-amino-2-fluorobenzonitrile.", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (s, 9H), 3.76 (s, 3H), 7.34 (s, 1H), 7.39-7.50 (m, 2H), 7.59 (s, 1H), 7.78-7.91 (m, 1H), 10.50 (Br.", "s., 1H).", "Method D: Rt: 1.99 min m/z: 404.1 (M−H)− Exact mass: 405.1.Compound 224: 4-(tert-Butylsulfamoyl)-3-chloro-N-(3-chloro-2,4-difluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide Compound 224 (405 mg) was prepared similarly as described for the synthesis of compound 226 using 3-chloro-2,4-difluoroaniline instead of 5-amino-2-fluorobenzonitrile.", "Method B: Rt: 1.16 min m/z: 438.1 (M−H)− Exact mass: 439.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (s, 9H), 3.78 (s, 3H), 7.31-7.40 (m, 2H), 7.61 (s, 1H), 7.65-7.75 (m, 1H), 10.16 (br.", "s., 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 241.6° C. Compound 225: 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-{[(1S)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 225 was prepared similarly as described for compound 199, using (S)-1,1,1-trifluoro-2-propylamine instead of (R)-1,1,1-trifluoro-2-propylamine.", "Method D: Rt: 1.86 min m/z: 451.0 (M−H)− Exact mass: 452.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=7.0 Hz, 3H), 3.78 (s, 3H), 3.92-4.05 (m, 1H), 7.56 (t, J=9.1 Hz, 1H), 7.68 (s, 1H), 7.98 (ddd, J=9.1, 4.8, 2.8 Hz, 1H), 8.19 (dd, J=5.7, 2.6 Hz, 1H), 8.51 (br.", "s., 1H), 10.67 (s, 1H).", "Compound 226: 4-(tert-Butylsulfamoyl)-3-chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-1H-pyrrole-2-carboxamide Methyl 3-chloro-4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate (4 g, 14.7 mmol) was dispensed in acetonitrile (25 mL) and tert-butylamine (4388 mg, 58.8 mmol) was added.", "The reaction mixture was stirred for 30 minutes at room temperature.", "The solids were filtered off and the filtrate was evaporated to dryness.", "The residue was purified on silica using a heptane to EtOAc gradient yielding methyl 4-(tert-butylsulfamoyl)-3-chloro-1-methyl-pyrrole-2-carboxylate (3.57 g) as a white powder after trituration in CH2Cl2 and diisopropylether.", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.14 (s, 9H), 3.82 (s, 3H), 3.86 (s, 3H), 7.35 (s, 1H), 7.69 (s, 1H).", "Methyl 4-(tert-butylsulfamoyl)-3-chloro-1-methyl-pyrrole-2-carboxylate (500 mg, 1.619 mmol) and 5-amino-2-fluorobenzonitrile (295.4 mg, 2.11 mmol) were dissolved in THF (10 mL) and cooled to 0° C. Lithium bis(trimethylsilyl)amide (5 mL, 1 M in toluene, 5 mmol) was added and the reaction mixture was allowed to reach room temperature.", "More lithium bis(trimethylsilyl)amide (1 mL, 1M in THF, 1 mmol) was added and the reaction mixture was stirred for 30 minutes more.", "The volatiles were removed under reduced pressure and the residue was partitioned between CH2Cl2 and water.", "The organic layer was loaded on a silica cartridge and a gradient form heptane to EtOAc was applied.", "The desired fractions were evaporated to dryness and the residue was crystallized from a EtOAc/heptane mixture.", "The precipitate was filtered off, triturated with diisopropylether and dried, yielding compound 226 (513 mg) as a white powder.", "Method B: Rt: 1.01 min m/z: 411.2 (M−H)− Exact mass: 412.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (s, 9H), 3.77 (s, 3H), 7.36 (s, 1H), 7.55 (t, J=9.1 Hz, 1H), 7.61 (s, 1H), 7.99 (ddd, J=9.2, 4.8, 2.8 Hz, 1H), 8.19 (dd, J=5.8, 2.8 Hz, 1H), 10.61 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 207.0° C. Compound 227: N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[1-(trifluoromethyl)cyclo-propyl]sulfamoyl}-1H-pyrrole-2-carboxamide 5-[(3-cyano-4-fluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (600 mg, 1.76 mmol) was mixed with 1-trifluoromethyl-1-cyclopropylamine (329 mg, 2.63 mmol), acetonitrile (10 mL), molecular sieves and Hunig's base (0.91 mL, 0.75 g/mL, 5.27 mmol) in a microwave vial (20 mL) and stirred at 100° C. for 1 hour and next at 110° C. for 1 hour under MW-irradiation.", "The reaction mixture was filtered and the filtrate concentrated to dryness.", "The obtained residue was purified using silica gel column chromatography (ethyl acetate in heptane from 10 to 70%) and further by preparative HPLC (Stationary phase: Uptisphere C18 ODB—10 μm, 200 g, 5 cm, Mobile phase: 0.25% NH4HCO3 solution in water, CH3CN), resulting in compound 227 (63 mg) after concentration and drying in vacuo at 50° C. Method B: Rt: 0.98 min m/z: 429.1 (M−H)− Exact mass: 430.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.09-1.21 (m, 4H), 3.91 (s, 3H), 7.31 (d, J=2.0 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.56-7.58 (m, 1H), 8.01 (ddd, J=9.2, 5.0, 2.8 Hz, 1H), 8.21 (dd, J=5.8, 2.8 Hz, 1H), 8.74 (br.", "s., 1H), 10.36 (br.", "s., 1H).", "Compound 228: N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[3-(trifluoromethyl)tetrahydrofuran-3-yl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 228 (153 mg) was prepared similarly as described for compound 227, using 3-(trifluoromethyl)tetrahydrofuran-3-amine hydrochloride instead of 1-trifluoromethyl-1-cyclopropylamine.", "Racemic compound 228 was separated in enantiomers by Prep SFC (Stationary phase: Chiralpak Daicel IC 20×250 mm, Mobile phase: CO2, 12-50% MeOH with 0.4% iPrNH2), resulting in compound 228a (first eluding) and 228b (second eluding, 41 mg).", "228a was further purified by Prep HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm, Mobile phase: 0.25% NH4HCO3 solution in water, CH3CN) resulting in compound 228a (28 mg) as white solid.", "228a: Method D: Rt: 1.79 min m/z: 459.0 (M−H)− Exact mass: 460.1.1H NMR (400 MHz, DMSO-d6) δ ppm 2.18 (dt, J=13.8, 8.1 Hz, 1H), 2.42-2.49 (m, 1H), 3.60 (q, J=7.8 Hz, 1H), 3.83 (td, J=8.3, 4.4 Hz, 1H), 3.92 (s, 3H), 3.91-3.96 (m, 1H), 4.04-4.10 (m, 1H), 7.35 (d, J=2.0 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.60 (d, J=1.8 Hz, 1H), 8.01 (ddd, J=9.2, 4.8, 2.9 Hz, 1H), 8.21 (dd, J=5.8, 2.8 Hz, 1H), 8.49 (br.", "s., 1H), 10.39 (s, 1H).", "228b: Method D: Rt: 1.79 min m/z: 459.0 (M−H)− Exact mass: 460.1.1H NMR (400 MHz, DMSO-d6) δ ppm 2.20 (dt, J=13.8, 8.1 Hz, 1H), 2.43-2.49 (m, 1H), 3.60 (q, J=7.7 Hz, 1H), 3.79-3.88 (m, 1H), 3.92 (s, 3H), 3.91-3.96 (m, 1H), 4.04-4.10 (m, 1H), 7.35 (d, J=2.0 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.62 (d, J=1.8 Hz, 1H), 8.01 (ddd, J=9.3, 4.9, 2.8 Hz, 1H), 8.21 (dd, J=5.7, 2.6 Hz, 1H), 8.46 (br.", "s., 1H), 10.38 (s, 1H).", "Synthesis of 3-(trifluoromethyl)tetrahydrofuran-3-amine hydrochloride A mixture of 3-oxotetrahydrofuran (30 g, 348.5 mmol), benzylamine (39.2 g, 365.8 mmol), MgSO4 (21 g, 174.5 mmol) and CH2Cl2 (200 mL) was stirred at 28° C. for 24 hours.", "The mixture was filtrated.", "The filtrate was concentrated in vacuo and the obtained residue (63.1 g) was used directly in the next step.", "The obtained residue (63 g) was dissolved in acetonitrile (600 mL).", "Trifluoroacetic acid (45 g, 394 mmol), potassium hydrogen fluoride (22.5 g, 288 mmol) and DMF (60 mL) were added to the mixture at 0° C. The mixture was stirred at 0° for 10 minutes.", "(trifluoromethyl)trimethylsilane (77 g, 541 mmol) was added to the reaction mixture and the mixture was stirred at ambient temperature for 12 h. Saturated aqueous Na2CO3 (200 mL) was added and the mixture was stirred for 5 min.", "The mixture was diluted with water (500 mL), and extracted with ethyl acetate (3×300 mL).", "The combined organic layers were washed with water and brine, dried over Na2SO4 and evaporated under reduced pressure.", "The obtained residue was dissolved in 2M HCl/MeOH and the solvent was evaporated.", "The resulting hydrochloride salt was crystallized from CH3CN to provide N-benzyl-3-(trifluoromethyl)tetrahydrofuran-3-amine (30.5 g).", "A mixture of N-benzyl-3-(trifluoromethyl)tetrahydrofuran-3-amine (30.5 g), palladium on alumina (1.5 g) and MeOH was stirred under H2 (20 psi) atmosphere at 28° C. for 12 hours.", "The mixture was filtered and the filtrate was concentrated in vacuo resulting in 3-(trifluoromethyl)tetrahydrofuran-3-amine hydrochloride (20.5 g).", "1H NMR (400 MHz, DMSO-d6) δ ppm 2.21-2.43 (m, 2H) 3.83-4.16 (m, 4H) 9.68 (br.", "s., 3H).", "Compound 229: N-(3,4-Difluorophenyl)-3-fluoro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide To ethyl 3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (1H NMR (400 MHz, DMSO-d6) δ ppm 1.15 (d, J=7.0 Hz, 3H), 1.28 (t, J=7.0 Hz, 3H), 3.83 (s, 3H), 3.90-4.02 (m, 1H), 4.28 (q, J=7.0 Hz, 2H), 7.60 (d, J=4.6 Hz, 1H), 8.59 (d, J=8.8 Hz, 1H); 1.10 g, 3.18 mmol) and 3,4-difluoroaniline (534 mg, 4.14 mmol) dissolved in THF (47 mL) under nitrogen atmosphere, at 0° C., lithium bis(trimethylsilyl)amide (12.7 mL, 1 M in toluene, 12.72 mmol) was added.", "The mixture was stirred 1 hour at 0° C. and further overnight at room temperature.", "The reaction mixture was quenched with NH4Cl (30 mL) solution and extracted with EtOAc (50 mL), diluted with brine (50 mL) and extracted again with EtOAc (50 mL).", "The combined organic layers were dried over sodium sulphate, filtered and concentrated.", "The residue (dissolved in 1 mL DMF) was purified by column chromatography on silica (120 g) with a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated and the solid residue was crystallized from warm methanol (20 mL) upon addition of water.", "The white crystals were filtered off and dried in vacuo at 50° C. overnight, resulting in compound 229 (945 mg).", "Method D: Rt: 1.93 min m/z: 428.1 (M−H)− Exact mass: 429.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (d, J=7.0 Hz, 3H), 3.80 (s, 3H), 3.91-4.04 (m, 1H), 7.37-7.48 (m, 2H), 7.54 (d, J=4.4 Hz, 1H), 7.76-7.86 (m, 1H), 8.59 (d, J=8.6 Hz, 1H), 10.26 (s, 1H).", "Compound 230: N-(3-Bromo-4-fluorophenyl)-3-fluoro-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide 3-fluoro-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxylic acid (153 mg, 0.579 mmol), HATU (275 mg, 0.724 mmol), Et3N (0.242 mL, 1.74 mmol), 3-bromo-4-fluoro-aniline (220 mg, 1.16 mmol) and DMF (1.1 mL) were stirred overnight at 65° C. The solution was subjected to column chromatography on a 120 g Reveleris silica gel cartridge using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated.", "The residue was dissolved in warm methanol (50 mL).", "Water was added until crystallisation began.", "The white crystals were filtered off and dried overnight in vacuo at 50° C. Method D: Rt: 2.04 min m/z: 436.2 (M−H)− Exact mass: 437.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.05 (d, J=6.6 Hz, 6H), 3.31-3.40 (m, 1H), 3.79 (s, 3H), 7.37 (t, J=8.8 Hz, 1H), 7.45 (d, J=4.4 Hz, 1H), 7.57 (d, J=7.3 Hz, 1H), 7.64 (ddd, J=9.0, 4.4, 2.6 Hz, 1H), 8.08 (dd, J=6.4, 2.4 Hz, 1H), 10.18 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 200.9° C. Compound 231: N-(3-Cyano-2,4-difluorophenyl)-3-fluoro-1-methyl-4-[(1-methyl-ethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 231 (88 mg) was prepared similarly as described for compound 230, using 3-amino-2,6-difluoro-benzonitrile instead of 3-bromo-4-fluoro-aniline.", "Method D: Rt: 1.86 min m/z: 399.3 (M−H)− Exact mass: 400.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.06 (d, J=6.4 Hz, 6H), 3.31-3.40 (m, 1H), 3.81 (s, 3H), 7.41-7.52 (m, 2H), 7.61 (d, J=7.3 Hz, 1H), 8.03 (td, J=8.9, 6.2 Hz, 1H), 9.96 (s, 1H).", "Compound 232: N-(3,4-Difluorophenyl)-3-fluoro-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 232 (144 mg) was prepared similarly as described for compound 230, using 3,4-difluoroaniline instead of 3-bromo-4-fluoro-aniline.", "Method D: Rt: 1.95 min m/z: 374.3 (M−H)− Exact mass: 375.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.05 (d, J=6.6 Hz, 6H), 3.31-3.41 (m, 1H), 3.79 (s, 3H), 7.35-7.49 (m, 3H), 7.57 (d, J=7.3 Hz, 1H), 7.76-7.87 (m, 1H), 10.22 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 195.8° C. Compound 233: 3-Fluoro-1-methyl-4-[(1-methylethyl)sulfamoyl]-N-(2,3,4-trifluorophenyl)-1H-pyrrole-2-carboxamide Compound 233 (89 mg) was prepared similarly as described for compound 230, using 2,3,4-trifluoroaniline instead of 3-bromo-4-fluoro-aniline.", "Method D: Rt: 1.95 min m/z: 392.3 (M−H)− Exact mass: 393.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.06 (d, J=6.6 Hz, 6H), 3.31-3.40 (m, 1H), 3.80 (s, 3H), 7.28-7.39 (m, 1H), 7.41-7.51 (m, 2H), 7.59 (d, J=7.3 Hz, 1H), 9.87 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 214.3° C. Compound 234: N-(3-Chloro-2,4-difluorophenyl)-3-fluoro-1-methyl-4-[(1-methyl-ethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 234 (95 mg) was prepared similarly as described for compound 230, using 3-chloro-2,4-difluoro-aniline instead of 3-bromo-4-fluoro-aniline.", "Method D: Rt: 2.03 min m/z: 408.3 (M−H)− Exact mass: 409.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.06 (d, J=6.4 Hz, 6H), 3.31-3.40 (m, 1H), 3.81 (s, 3H), 7.35 (td, J=9.0, 2.1 Hz, 1H), 7.48 (d, J=4.6 Hz, 1H), 7.59 (d, J=7.3 Hz, 1H), 7.65 (td, J=8.7, 5.8 Hz, 1H), 9.83 (s, 1H).", "Compound 235: N-(3-Chloro-4-fluorophenyl)-3-fluoro-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 235 (156 mg) was prepared similarly as described for compound 230, using 3-chloro-4-fluoro-aniline instead of 3-bromo-4-fluoro-aniline.", "Method D: Rt: 2.03 min m/z: 390.3 (M−H)− Exact mass: 391.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.05 (d, J=6.6 Hz, 6H), 3.31-3.40 (m, 1H), 3.80 (s, 3H), 7.40 (t, J=9.1 Hz, 1H), 7.45 (d, J=4.6 Hz, 1H), 7.54-7.64 (m, 2H), 7.96 (dd, J=6.8, 2.4 Hz, 1H), 10.19 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 201.9° C. Compound 236: N-(3-Chloro-2,4-difluorophenyl)-4-{[2,2-difluorocyclopentyl]sulfamoyl}-1-methyl-1H-pyrrole-2-carboxamide 5-[(3-chloro-2,4-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (532.5 mg, 1.442 mmol), 2,2-difluorocyclopentan-1-amine hydrochloride (261 mg, 1.66 mmol) and Et3N (0.501 mL, 3.61 mmol) in acetonitrile (50 mL) was stirred and refluxed 2 hours.", "The reaction mixture was concentrated and the obtained residue was dissolved in EtOAc (50 mL) washed with HCl 1M, dried over sodium sulphate, filtered and concentrated.", "The obtained residue was subjected to silica gel column chromatography using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated resulting in compound 236 (518 mg) as a white solid.", "Racemic compound 236 was separated in its enantiomers 236a (first eluding) and 236b (second eluding) via Prep SFC (Stationary phase: Chiralpak Diacel AD 20×250 mm, Mobile phase: CO2, 30% EtOH-iPrOH (50-50) with 0.2% iPrNH2) 236a: Method D: Rt: 1.98 min m/z: 452.3 (M−H)− Exact mass: 453.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.41-1.72 (m, 3H), 1.76-1.87 (m, 1H), 1.90-2.18 (m, 2H), 3.61-3.78 (m, 1H), 3.89 (s, 3H), 7.31-7.38 (m, 2H), 7.53 (td, J=8.7, 5.9 Hz, 1H), 7.58 (d, J=1.5 Hz, 1H), 7.81 (d, J=8.8 Hz, 1H), 10.12 (s, 1H).", "236b: Method D: Rt: 1.98 min m/z: 452.3 (M−H)− Exact mass: 453.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.40-1.74 (m, 3H), 1.75-1.89 (m, 1H), 1.90-2.18 (m, 2H), 3.62-3.78 (m, 1H), 3.89 (s, 3H), 7.29-7.39 (m, 2H), 7.48-7.61 (m, 2H), 7.81 (d, J=8.1 Hz, 1H), 10.12 (s, 1H).", "Compound 237: N-(3-Cyano-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-di-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide 5-[(3-cyano-4-fluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (0.25 g, 0.73 mmol) was dissolved in acetonitrile (6 mL) and dried with molecular sieves 4A powder over a period of 30 minutes in a pressure tube.", "2,2,2-trifluoro-1,1-dimethyl-ethylamine (139 mg, 1.1 mmol) and sodium bicarbonate (307.3 mg, 3.66 mmol) were dispersed in acetonitrile (2 mL), dried with molecular sieves 4A powder over a period of 30 minutes and the resulting mixture was added to the pressure tube, which was flushed with nitrogen, capped and stirred in a heating block at 80° C. for 24 hours.", "Then the reaction mixture was filtered and rinsed using dichloromethane (50 mL).", "The filtrate was concentrated in vacuo and the obtained residue was purified using silica gel column chromatography (gradient elution: EtOAc-heptane 0:100 to 100:0).", "The desired fractions were concentrated under reduced pressure and the obtained powder was dried in a vacuum oven at 55° C. for 24 hours yielding compound 237 (213 mg).", "Method D: Rt: 1.89 min m/z: 431.1 (M−H)− Exact mass: 432.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.36 (s, 6H), 3.93 (s, 3H), 7.35 (d, J=2.0 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.59 (d, J=1.8 Hz, 1H), 7.84-8.15 (m, 2H), 8.21 (dd, J=5.9, 2.6 Hz, 1H), 10.38 (br.", "s., 1H).", "Compound 238: N-(3-Cyano-4-fluorophenyl)-1-methyl-4-[(3,3,3-trifluoro-1-methyl-propyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 238 (206 mg) was prepared similarly as described for compound 237, using 4,4,4-trifluorobutan-2-amine instead of 2,2,2-trifluoro-1,1-dimethyl-ethylamine and 48 hours reaction time instead of 24 hours.", "Method D: Rt: 1.86 min m/z: 431.1 (M−H)− Exact mass: 432.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.06 (d, J=6.6 Hz, 3H), 2.29-2.47 (m, 2H), 3.50 (sxt, J=6.6 Hz, 1H), 3.93 (s, 3H), 7.36 (d, J=2.0 Hz, 1H), 7.40-7.88 (m, 3H), 8.01 (ddd, J=9.2, 5.0, 2.8 Hz, 1H), 8.22 (dd, J=5.8, 2.8 Hz, 1H), 10.38 (br.", "s., 1H).", "Compound 239: N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[(1S)-1-(trifluoromethyl)-propyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 239 (236 mg) was prepared similarly as described for compound 237, using (S)-1-trifluoromethyl-propylamine instead of 2,2,2-trifluoro-1,1-dimethyl-ethylamine.", "Method D: Rt: 1.89 min m/z: 431.1 (M−H)− Exact mass: 432.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.70 (t, J=7.4 Hz, 3H), 1.32-1.51 (m, 1H), 1.56-1.74 (m, 1H), 3.68-3.85 (m, 1H), 3.95 (s, 3H), 7.37 (d, J=2.0 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.64 (d, J=1.8 Hz, 1H), 8.02 (ddd, J=9.2, 5.0, 2.8 Hz, 1H), 8.06-8.33 (m, 2H), 10.37 (br.", "s., 1H).", "Compound 240: N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[(1R)-1-(trifluoromethyl)-propyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 240 (244 mg) was prepared similarly as described for compound 237, using (R)-1-trifluoromethyl-propylamine instead of 2,2,2-trifluoro-1,1-dimethyl-ethylamine Method D: Rt: 1.89 min m/z: 431.1 (M−H)− Exact mass: 432.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.70 (t, J=7.4 Hz, 3H), 1.35-1.53 (m, 1H), 1.55-1.73 (m, 1H), 3.62-3.83 (m, 1H), 3.92 (s, 3H), 7.37 (d, J=1.8 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.63 (d, J=1.5 Hz, 1H), 8.02 (ddd, J=9.2, 4.8, 2.9 Hz, 1H), 8.06-8.51 (m, 2H), 10.37 (br.", "s., 1H).", "Compound 241: N-(3-Cyano-4-fluorophenyl)-1-methyl-4-{[1-(trifluoromethyl)cyclo-butyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 241 (119 mg) was prepared similarly as described for compound 237, using 1-trifluoromethyl-cyclobutylamine instead of 2,2,2-trifluoro-1,1-dimethyl-ethylamine and 48 hours reaction time instead of 24 hours.", "Method D: Rt: 1.91 min m/z: 443.1 (M−H)− Exact mass: 444.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.67-1.90 (m, 2H), 2.23-2.36 (m, 2H), 2.39-2.48 (m, 2H), 3.94 (s, 3H), 7.39 (d, J=1.8 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.63 (d, J=1.8 Hz, 1H), 8.02 (ddd, J=9.2, 5.0, 2.8 Hz, 1H), 8.22 (dd, J=5.8, 2.8 Hz, 1H), 8.37 (br.", "s., 1H), 10.39 (br.", "s., 1H).", "Compound 242: N-(3-Cyano-4-fluorophenyl)-4-{[2-fluoro-1-(fluoromethyl)ethyl]sulfamoyl}-1-methyl-1H-pyrrole-2-carboxamide Compound 242 (162 mg) was prepared similarly as described for compound 237, using 1,3-difluoropropan-2-amine hydrochloride instead of 2,2,2-trifluoro-1,1-dimethyl-ethylamine.", "Method D: Rt: 1.70 min m/z: 399.0 (M−H)− Exact mass: 400.1.1H NMR (400 MHz, DMSO-d6) δ ppm 3.50-3.76 (m, 1H), 3.92 (s, 3H), 4.26-4.54 (m, 4H), 7.37 (d, J=2.0 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.63 (d, J=1.5 Hz, 1H), 7.73-8.17 (m, 2H), 8.22 (dd, J=5.8, 2.8 Hz, 1H), 10.38 (br.", "s., 1H).", "Compound 244: N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[(1-methylcyclopropyl)-sulfamoyl]pyrrole-2-carboxamide Compound 244 (144 mg) was prepared similarly as described for compound 237, using (1-methylcyclopropyl)amine hydrochloride instead of 2,2,2-trifluoro-1,1-dimethyl-ethylamine.", "Method B: Rt: 0.93 min m/z: 375.1 (M−H)− Exact mass: 376.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.30-0.47 (m, 2H), 0.63-0.73 (m, 2H), 1.18 (s, 3H), 3.93 (s, 3H), 7.33 (d, J=2.0 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.56 (d, J=1.5 Hz, 1H), 7.68 (s, 1H), 8.02 (ddd, J=9.2, 5.0, 2.8 Hz, 1H), 8.22 (dd, J=5.9, 2.6 Hz, 1H), 10.36 (s, 1H).", "Compound 245: N-(3-cyano-4-fluoro-phenyl)-4-[(3,3-difluoro-1-methyl-cyclobutyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide Compound 245 (243 mg) was prepared similarly as described for compound 237, using 3,3-difluoro-1-methylcyclobutanamine hydrochloride instead of 2,2,2-trifluoro-1,1-dimethyl-ethylamine.", "Method B: Rt: 0.99 min m/z: 425.2 (M−H)− Exact mass: 426.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.39 (s, 3H), 2.40-2.57 (m, 2H), 2.74-2.95 (m, 2H), 3.93 (s, 3H), 7.35 (d, J=2.0 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.61 (d, J=1.8 Hz, 1H), 7.87 (br.", "s., 1H), 8.01 (ddd, J=9.2, 4.8, 2.9 Hz, 1H), 8.21 (dd, J=5.7, 2.6 Hz, 1H), 10.37 (br.", "s., 1H).", "Compound 246: N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-{[1-methyl-1-(trifluoro-methyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 246 (130 mg) was prepared similarly as described for compound 237, using 1,1,1-trifluoro-2-methylbutan-2-amine hydrochloride instead of 2,2,2-trifluoro-1,1-dimethyl-ethylamine and 48 hours reaction time instead of 24 hours.", "Method B: Rt: 1.05 min m/z: 445.2 (M−H)− Exact mass: 446.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.79 (t, J=7.4 Hz, 3H), 1.37 (s, 3H), 1.46-1.58 (m, 1H), 1.73-1.89 (m, 1H), 3.92 (s, 3H), 7.35 (d, J=1.8 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.58 (d, J=1.8 Hz, 1H), 7.89 (br.", "s., 1H), 8.02 (ddd, J=9.2, 4.9, 2.9 Hz, 1H), 8.21 (dd, J=5.8, 2.8 Hz, 1H), 10.37 (s, 1H).", "Compound 247: N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-{[4-(trifluoromethyl)tetrahydropyran-4-yl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 247 (23 mg) was prepared similarly as described for compound 237, using 4-(trifluoromethyl)oxan-4-amine hydrochloride instead of 2,2,2-trifluoro-1,1-dimethyl-ethylamine and 48 hours reaction time instead of 24 hours.", "An extra purification was performed via Prep HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm, Mobile phase: 0.25% NH4HCO3 solution in water, MeOH).", "Method B: Rt: 0.96 min m/z: 473.1 (M−H)− Exact mass: 474.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.64-1.79 (m, 2H), 2.11 (d, J=13.4 Hz, 2H), 3.50 (t, J=11.4 Hz, 2H), 3.70-3.81 (m, 2H), 3.93 (s, 3H), 7.36 (d, J=1.8 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.57-7.65 (m, 1H), 7.92 (br.", "s., 1H), 8.02 (ddd, J=9.2, 4.8, 2.9 Hz, 1H), 8.22 (dd, J=5.8, 2.8 Hz, 1H), 10.41 (br.", "s., 1H).", "Compound 248: N-(3-cyano-4-fluoro-phenyl)-4-{[1-ethyl-1-(trifluoromethyl)propyl]sulfamoyl}-1-methyl-1H-pyrrole-2-carboxamide Compound 248 (40 mg) was prepared similarly as described for compound 237, using 3-(trifluoromethyl)pentan-3-amine hydrochloride instead of 2,2,2-trifluoro-1,1-dimethyl-ethylamine.", "Method B: Rt: 1.11 min m/z: 459.2 (M−H)− Exact mass: 460.1 1H NMR (400 MHz, DMSO-d6) δ ppm 0.82 (t, J=7.4 Hz, 6H), 1.70-1.83 (m, 2H), 1.84-1.97 (m, 2H), 3.92 (s, 3H), 7.34 (d, J=1.8 Hz, 1H), 7.47-7.61 (m, 2H), 7.73 (br.", "s., 1H), 8.02 (ddd, J=9.2, 4.8, 2.9 Hz, 1H), 8.21 (dd, J=5.7, 2.6 Hz, 1H), 10.38 (br.", "s., 1H).", "Compound 249: N-(3-cyano-4-fluoro-phenyl)-4-[(2-fluoro-1,1-dimethyl-ethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide Compound 249 (178 mg) was prepared similarly as described for compound 237, using 1-fluoro-2-methylpropan-2-amine instead of 2,2,2-trifluoro-1,1-dimethyl-ethylamine Method B: Rt: 0.94 min m/z: 395.1 (M−H)− Exact mass: 396.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.13-1.20 (m, 6H), 3.92 (s, 3H), 4.24 (d, J=47.5 Hz, 2H), 7.35 (d, J=2.0 Hz, 1H), 7.41 (br.", "s., 1H), 7.53 (t, J=9.1 Hz, 1H), 7.58 (d, J=1.8 Hz, 1H), 8.01 (ddd, J=9.2, 4.9, 2.6 Hz, 1H), 8.22 (dd, J=5.9, 2.6 Hz, 1H), 10.36 (br.", "s., 1H).", "Compound 250: N-(3-Bromophenyl)-3-chloro-1-methyl-4-{[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl}-1H-pyrrole-2-carboxamide 3-bromoaniline (92 mg, 0.53 mmol) and methyl 3-chloro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (143 mg, 0.41 mmol) were dissolved in THF (10 mL).", "Lithium bis(trimethylsilyl)amide (1M in THF) (1.23 mL, 1 M, 1.23 mmol) was added and the reaction mixture was stirred overnight.", "The reaction mixture was quenched with sat.", "NH4Cl (aq) (5 mL).", "The aqueous layer was extracted with CH2Cl2 (2×5 mL).", "The combined organic layers were evaporated to dryness and the residue was purified on silica using a heptane to EtOAc gradient.", "The obtained products was crystallized from CH2Cl2, triturated with diisopropylether and dried yielding, compound 250 (156 mg) as a white powder.", "Method D: Rt: 2.05 min m/z: 487.9 (M−H)− Exact mass: 489.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=7.0 Hz, 3H), 3.77 (s, 3H), 3.91-4.01 (m, 1H), 7.29-7.37 (m, 2H), 7.61-7.69 (m, 2H), 7.97-8.04 (m, 1H), 8.48 (s, 1H), 10.51 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 197.9° C. Compound 251: N-(3-Bromophenyl)-3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]-1H-pyrrole-2-carboxamide 3-fluoro-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carb oxy c acid (250 mg, 0.855 mmol), HATU (407 mg, 1.07 mmol), Et3N (0.36 mL, 2.57 mmol) and 3-bromoaniline (294 mg, 1.71 mmol) in DMF (4 mL) were stirred 4 hours at 65° C. The solution was subjected to column chromatography on a 120 g silica gel Reveleris cartridge using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated and compound 251 was crystallized by dissolving the obtained liquid residue in methanol (30 mL) upon addition of water.", "The white crystals were filtered off and dried overnight in vacuo at 50° C. Method D: Rt: 1.81 min m/z: 446.0 (M−H)− Exact mass: 447.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.56 (s, 3H), 3.80 (s, 3H), 4.17 (d, J=6.4 Hz, 2H), 4.65 (d, J=6.2 Hz, 2H), 7.26-7.35 (m, 2H), 7.50 (d, J=4.6 Hz, 1H), 7.62 (dt, J=6.5, 2.4 Hz, 1H), 7.96-8.01 (m, 1H), 8.30 (s, 1H), 10.19 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 193.4° C. Compound 252: N-(3-chloro-2,4-difluoro-phenyl)-4-[(2,2-difluoro-1-methyl-ethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide 5-[(3-chloro-2,4-difluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (0.25 g, 0.68 mmol) was dissolved in acetonitrile (6 mL) in a pressure tube and this was dried with powdered molecular sieves (4 Å) over a period of 30 minutes.", "Another tube was loaded with 1,1-difluoropropan-2-amine (1.0 mmol) and sodium bicarbonate (284 mg, 3.39 mmol) and this was dispersed in acetonitrile (2 mL) and dried with powdered molecular sieves (4 Å) over a period of 30 minutes.", "This was added to the pressure tube which was flushed with nitrogen, capped and stirred in a heating block at 80° C. for 24 hours.", "Then the reaction mixture was filtered and rinsed using dichloromethane (50 mL).", "The filtrate was concentrated in vacuo and the obtained residue was purified using silica gel column chromatography (gradient elution: EtOAc-heptane 0:100 to 100:0).", "The obtained powder was dried in a vacuum oven at 55° C. for 24 hours yielding compound 252 (204 mg) as a white powder.", "Method B: Rt: 1.00 min m/z: 426.1 (M−H)− Exact mass: 427.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.01 (d, J=7.0 Hz, 3H), 3.39-3.59 (m, 1H), 3.92 (s, 3H), 5.91 (td, J=55.9, 2.4 Hz, 1H), 7.29-7.39 (m, 2H), 7.46-7.58 (m, 1H), 7.63 (d, J=1.5 Hz, 1H), 7.85 (br.", "s., 1H), 10.14 (br.", "s., 1H).", "Compound 253: N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-{[1-(trifluoromethyl)-cyclopropyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 253 (104 mg) was prepared similarly as described for compound 252, using 1-trifluoromethyl-1-cyclopropylamine instead of 1,1-difluoropropan-2-amine and 48 hours reaction time instead of 24 hours.", "An extra purification was performed via Prep HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm, Mobile phase: 0.25% NH4HCO3 solution in water, MeOH).", "Method B: Rt: 1.05 min m/z: 456.1 (M−H)− Exact mass: 457.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.07-1.24 (m, 4H), 3.89 (s, 3H), 7.29 (d, J=1.8 Hz, 1H), 7.35 (td, J=9.0, 1.9 Hz, 1H), 7.46-7.56 (m, 1H), 7.57 (d, J=1.8 Hz, 1H), 8.65 (br.", "s, 1H), 10.13 (br.", "s., 1H).", "Compound 254: N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethyl-ethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 254 (75 mg) was prepared similarly as described for compound 252, using 2,2,2-trifluoro-1,1-dimethyl-ethylamine instead of 1,1-difluoropropan-2-amine.", "An extra purification was performed via Prep HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm, Mobile phase: 0.25% NH4HCO3 solution in water, MeOH).", "Method B: Rt: 1.09 min m/z: 458.1 (M−H)− Exact mass: 459.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.37 (s, 6H), 3.90 (s, 3H), 7.28-7.42 (m, 2H), 7.47-7.57 (m, 1H), 7.59 (d, J=1.8 Hz, 1H), 8.08 (br.", "s., 1H), 10.16 (br.", "s., 1H).", "Compound 255: N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-[(1-methylcyclopropyl)-sulfamoyl]-1H-pyrrole-2-carboxamide Compound 255 (211 mg) was prepared similarly as described for compound 252, using (1-methylcyclopropyl)amine hydrochloride instead of 1,1-difluoropropan-2-amine.", "Method B: Rt: 1.00 min m/z: 402.1 (M−H)− Exact mass: 403.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.36-0.44 (m, 2H), 0.66-0.75 (m, 2H), 1.20 (s, 3H), 3.90 (s, 3H), 7.30 (d, J=2.0 Hz, 1H), 7.34 (td, J=8.9, 2.0 Hz, 1H), 7.48-7.55 (m, 1H), 7.56 (d, J=1.5 Hz, 1H), 7.67 (br.", "s., 1H), 10.13 (br.", "s., 1H).", "Compound 256: N-(3-chloro-2,4-difluoro-phenyl)-4-[(3,3-difluoro-1-methyl-cyclo-butyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide Compound 256 (258 mg) was prepared similarly as described for compound 252, using 3,3-difluoro-1-methylcyclobutanamine instead of 1,1-difluoropropan-2-amine.", "Method B: Rt: 1.05 min m/z: 452.1 (M−H)− Exact mass: 453.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.41 (s, 3H), 2.43-2.57 (m, 2H), 2.73-2.94 (m, 2H), 3.90 (s, 3H), 7.30-7.40 (m, 2H), 7.48-7.57 (m, 1H), 7.60 (d, J=1.8 Hz, 1H), 7.87 (br.", "s., 1H), 10.14 (br.", "s., 1H).", "Compound 257: N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-{[1-methyl-1-(trifluoro-methyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 257 (71 mg) was prepared similarly as described for compound 252, using 1,1,1-trifluoro-2-methylbutan-2-amine hydrochloride instead of 1,1-difluoropropan-2-amine and 48 h reaction time instead of 24 h. An extra purification was performed via Prep HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm, Mobile phase: 0.25% NH4HCO3 solution in water, MeOH).", "Method B: Rt: 1.13 min m/z: 472.1 (M−H)− Exact mass: 473.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.81 (t, J=7.3 Hz, 3H), 1.38 (s, 3H), 1.53 (dq, J=14.0, 7.2 Hz, 1H), 1.73-1.89 (m, 1H), 3.89 (s, 3H), 7.29-7.39 (m, 2H), 7.47-7.56 (m, 1H), 7.57 (d, J=1.8 Hz, 1H), 7.89 (br.", "s., 1H), 10.14 (br.", "s., 1H).", "Compound 258: N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-[[4-(trifluoromethyl)-tetrahydropyran-4-yl]sulfamoyl]-1H-pyrrole-2-carboxamide Compound 258 (29 mg) was prepared similarly as described for compound 252, using 4-(trifluoromethyl)oxan-4-amine hydrochloride instead of 1,1-difluoropropan-2-amine and 48 h reaction time instead of 24 h. An extra purification was performed via Prep HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm, Mobile phase: 0.25% NH4HCO3 solution in water, MeOH).", "Method B: Rt: 1.03 min m/z: 500.1 (M−H)− Exact mass: 501.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.64-1.78 (m, 2H), 2.06-2.18 (m, 2H), 3.51 (t, J=11.4 Hz, 2H), 3.71-3.82 (m, 2H), 3.90 (s, 3H), 7.27-7.41 (m, 2H), 7.49-7.57 (m, 1H), 7.57-7.61 (m, 1H), 7.91 (br.", "s., 1H), 10.17 (br.", "s., 1H).", "Compound 259: N-(3-chloro-2,4-difluoro-phenyl)-4-[[1-ethyl-1-(trifluoromethyl)-propyl]sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide Compound 259 (114 mg) was prepared similarly as described for compound 252, using 3-(trifluoromethyl)pentan-3-amine hydrochloride instead of 1,1-difluoropropan-2-amine.", "Method B: Rt: 1.16 min m/z: 486.1 (M−H)− Exact mass: 487.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.84 (t, J=7.4 Hz, 6H), 1.68-2.02 (m, 4H), 3.90 (s, 3H), 7.29-7.41 (m, 2H), 7.47-7.54 (m, 1H), 7.55 (d, J=1.5 Hz, 1H), 7.62-7.94 (m, 1H), 10.14 (br.", "s., 1H).", "Compound 260: N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-[(3,3,3-trifluoro-1-methylpropyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 260 (252 mg) was prepared similarly as described for compound 252, using 4,4,4-trifluorobutan-2-amine instead of 1,1-difluoropropan-2-amine.", "Method B: Rt: 1.06 min m/z: 458.1 (M−H)− Exact mass: 459.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.08 (d, J=6.6 Hz, 3H), 2.24-2.49 (m, 2H), 3.50 (sxt, J=6.5 Hz, 1H), 3.92 (s, 3H), 7.20-7.41 (m, 2H), 7.42-7.81 (m, 3H), 10.13 (br.", "s., 1H).", "Compound 261: N-(3-chloro-2,4-difluoro-phenyl)-4-[(2-fluoro-1,1-dimethyl-ethyl)sulfamoyl]-1-methyl-1H-pyrrole-2-carboxamide Compound 261 (143 mg) was prepared similarly as described for compound 252, using 1-fluoro-2-methylpropan-2-amine instead of 1,1-difluoropropan-2-amine.", "The desired fractions were concentrated under reduced pressure yielding a powder.", "An extra purification was performed via Prep HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm, Mobile phase: 0.25% NH4HCO3 solution in water, MeOH).", "Method B: Rt: 1.03 min m/z: 422.1 (M−H)− Exact mass: 423.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.13-1.22 (m, 6H), 3.90 (s, 3H), 4.24 (d, J=47.3 Hz, 2H), 7.29-7.37 (m, 2H), 7.41 (br.", "s., 1H), 7.49-7.55 (m, 1H), 7.56 (d, J=1.8 Hz 1H), 10.13 (br.", "s., 1H).", "Compound 262: N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-{[(1S)-1-(trifluoro-methyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 262 (227 mg) was prepared similarly as described for compound 252, using (S)-1-trifluoromethyl-propylamine instead of 1,1-difluoropropan-2-amine.", "Method B: Rt: 1.08 min m/z: 458.1 (M−H)− Exact mass: 459.0.1H NMR (400 MHz, DMSO-d6) δ ppm 0.73 (t, J=7.5 Hz, 3H), 1.38-1.52 (m, 1H), 1.58-1.73 (m, 1H), 3.62-3.84 (m, 1H), 3.89 (s, 3H), 7.28-7.40 (m, 2H), 7.45-7.58 (m, 1H), 7.63 (d, J=1.5 Hz, 1H), 8.15 (br.", "s., 1H), 10.12 (br.", "s, 1H).", "Compound 263: N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-{[1-(trifluoromethyl)-cyclobutyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 263 (154 mg) was prepared similarly as described for compound 252, using 1-trifluoromethyl-cyclobutylamine instead of 1,1-difluoropropan-2-amine and 48 h reaction time instead of 24 h. An extra purification was performed via Prep HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm, Mobile phase: 0.25% NH4HCO3 solution in water, MeOH).", "Method B: Rt: 1.10 min m/z: 470.1 (M−H)− Exact mass: 471.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.71-1.92 (m, 2H), 2.21-2.37 (m, 2H), 2.39-2.49 (m, 2H), 3.91 (s, 3H), 7.25-7.43 (m, 2H), 7.46-7.58 (m, 1H), 7.62 (d, J=1.8 Hz, 1H), 8.38 (br.", "s., 1H), 10.16 (br.", "s., 1H).", "Compound 264: N-(3-chloro-2,4-difluoro-phenyl)-4-{[2-fluoro-1-(fluoromethyl)-ethyl]sulfamoyl}-1-methyl-1H-pyrrole-2-carboxamide Compound 264 (231 mg) was prepared similarly as described for compound 252, using 1,3-difluoropropan-2-amine hydrochloride instead of 1,1-difluoropropan-2-amine.", "Method B: Rt: 0.96 min m/z: 426.1 (M−H)− Exact mass: 427.0.1H NMR (400 MHz, DMSO-d6) δ ppm 3.53-3.75 (m, 1H), 3.89 (s, 3H), 4.28-4.53 (m, 4H), 7.24-7.41 (m, 2H), 7.45-7.58 (m, 1H), 7.62 (d, J=1.8 Hz, 1H), 8.04 (br.", "s., 1H), 10.02 (br.", "s, 1H).", "Compound 265: N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-{[(1R)-1-(trifluoro-methyl)propyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 265 (241 mg) was prepared similarly as described for compound 252, using (R)-1,1,1-trifluoro-2-butylamine instead of 1,1-difluoropropan-2-amine and 48 hours reaction time instead of 24 h. Method B: Rt: 1.09 min m/z: 458.1 (M−H)− Exact mass: 459.0.1H NMR (400 MHz, DMSO-d6) δ ppm 0.73 (t, J=7.5 Hz, 3H), 1.38-1.52 (m, 1H), 1.58-1.73 (m, 1H), 3.67-3.83 (m, 1H), 3.89 (s, 3H), 7.29-7.39 (m, 2H), 7.45-7.58 (m, 1H), 7.63 (d, J=1.5 Hz, 1H), 8.16 (br.", "s., 1H), 10.13 (br.", "s., 1H).", "Compound 266: N-(3-chloro-2,4-difluoro-phenyl)-1-methyl-4-{[3-(trifluoromethyl)-tetrahydrofuran-3-yl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 266 (140 mg) was prepared similarly as described for compound 252, using 3-(trifluoromethyl)tetrahydrofuran-3-amine hydrochloride instead of 1,1-difluoropropan-2-amine.", "An extra purification was performed via Prep HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm, Mobile phase: 0.25% NH4HCO3 solution in water, MeOH).", "Method B: Rt: 1.03 min m/z: 486.1 (M−H)− Exact mass: 487.0.1H NMR (400 MHz, DMSO-d6) δ ppm 2.19 (dt, J=13.8, 8.1 Hz, 1H), 2.40-2.48 (m, 1H), 3.62 (q, J=7.8 Hz, 1H), 3.79-3.87 (m, 1H), 3.89 (s, 3H), 3.95 (d, J=10.1 Hz, 1H), 4.01-4.11 (m, 1H), 7.27-7.41 (m, 2H), 7.49-7.57 (m, 1H), 7.60 (d, J=1.8 Hz, 1H), 8.52 (br.", "s., 1H), 10.15 (br.", "s., 1H).", "Compound 267: 3-chloro-N-(3,4-difluorophenyl)-1-methyl-4-{[1-(trifluoromethyl)-cyclobutyl]sulfamoyl}-1H-pyrrole-2-carboxamide Methyl 3-chloro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxylate (83 mg, 0.22 mmol) and 3,4-difluoroaniline (37 mg, 0.29 mmol) were dissolved in dry THF (10 mL) and cooled to 0° C. Lithium bis(trimethylsilyl)amide (1M in THF) (0.66 mL, 1 M, 0.66 mmol) was added dropwise and the reaction mixture was allowed to reach room temperature.", "The volatiles were removed under reduced pressure and the residue was purified on silica using a heptane to EtOAc gradient and further by preparative HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm, Mobile phase: 0.25% NH4HCO3 solution in water, CH3CN); —resulting in compound 267 (60 mg).", "Method B: Rt: 1.11 min m/z: 470.1 (M−H)− Exact mass: 471.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.74-1.91 (m, 2H), 2.24-2.36 (m, 2H), 2.41-2.50 (m, 2H), 3.78 (s, 3H), 7.38-7.51 (m, 2H), 7.65 (s, 1H), 7.80-7.90 (m, 1H), 8.59 (br.", "s., 1H), 10.55 (s, 1H).", "Compound 268: 3-chloro-N-(3-chloro-4-fluoro-phenyl)-1-methyl-4-{[1-(trifluoro-methyl)cyclobutyl]sulfamoyl}-1H-pyrrole-2-carboxamide Methyl 3-chloro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxylate (155 mg, 0.2 mmol) and 3-chloro-4-fluoro-aniline (38 mg, 0.26 mmol) were dissolved in dry THF (10 mL) and cooled to 0° C. Lithium bis(trimethylsilyl)amide (1M in THF) (0.6 mL, 1 M, 0.6 mmol) was added dropwise and the reaction mixture was allowed to reach room temperature.", "After 1 hour more lithium bis(trimethylsilyl)amide (1M in THF) (0.6 mL, 1 M, 0.6 mmol) was added and the reaction mixture was stirred for another hour.", "The volatiles were removed under reduced pressure and the residue was purified on silica using a heptane to EtOAc gradient and further Preparative HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm, Mobile phase: 0.25% NH4HCO3 solution in water, CH3CN)—resulting in compound 268 (23 mg).", "Method B: Rt: 1.17 min m/z: 486.0 (M−H)− Exact mass: 487.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.72-1.88 (m, 2H), 2.20-2.36 (m, 2H), 2.41-2.53 (m, 2H), 3.78 (s, 3H), 7.43 (t, J=9.1 Hz, 1H), 7.58-7.69 (m, 2H), 7.99 (dd, J=6.8, 2.4 Hz, 1H), 8.61 (br.", "s., 1H), 10.53 (s, 1H).", "Compound 269: 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-[(1-methylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Methyl 3-chloro-4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate (1.5 g, 5.51 mmol) was dissolved in acetonitrile (8 mL) and dried on molecular sieves.", "NaHCO3 (1389 mg, 16.54 mmol) was added.", "Isopropylamine (493.71 mg, 8.27 mmol) was dissolved in acetonitrile (2 mL) and dried on molecular sieves.", "The two suspensions were combined and heated at 70° C. for 2 hours.", "The reaction mixture was filtered and washed with acetonitrile and evaporated to dryness to afford a crude residue (1.68 g).", "The crude was purified using silica gel column chromatography (ethyl acetate in heptane from 0 to 100%) to afford methyl 3-chloro-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxylate (1.62 g).", "Method D: Rt: 1.62 min m/z: 293.0 (M−H)− Exact mass: 294.0.Methyl 3-chloro-4-(isopropylsulfamoyl)-1-methyl-pyrrole-2-carboxylate (500 mg, 1.7 mmol) and 5-amino-2-fluorobenzonitrile (0.26 g, 1.86 mmol) were dissolved in dry THF under a blanket of nitrogen.", "The reaction mixture was cooled to 0° C. and lithium bis(trimethylsilyl)amide (1M in toluene) (5.09 mL, 1 M, 5.09 mmol) was added over a period of 2 minutes.", "The resulting mixture was stirred for 2 minutes while cooling was continued.", "The mixture was quenched with saturated ammonium chloride (50 mL) and extracted using EtOAc (2×100 mL).", "The combined extracts were washed with brine (50 mL), dried on Na2SO4, filtered and concentrated in vacuo to afford a dark brown powder which was purified using silica gel column chromatography (ethyl acetate in heptane from 0 to 100%) and further via Prep HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm, Mobile phase: 0.25% NH4HCO3 solution in water, CH3CN) yielding compound 269 (449 mg).", "Method B: Rt: 0.94 min m/z: 397.1 (M−H)− Exact mass: 398.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.05 (d, J=6.6 Hz, 6H), 3.24-3.38 (m, 1H), 3.77 (s, 3H), 7.49 (br.", "d, J=6.8 Hz, 1H), 7.55 (t, J=9.1 Hz, 1H), 7.62 (s, 1H), 7.99 (ddd, J=9.2, 4.8, 2.8 Hz, 1H), 8.20 (dd, J=5.8, 2.8 Hz, 1H), 10.67 (br.", "s., 1H).", "Compound 270: 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-[(2,2,2-trifluoro-1,1-dimethylethyl)sulfamoyl]-1H-pyrrole-2-carboxamide Compound 270 was prepared similarly as described for compound 269, using 3 equiv 2,2,2-trifluoro-1,1-dimethyl-ethylamine, instead of 1.5 equiv isopropylamine (heating was continued for more then 44 hours at 80° C. instead of 2 hours at 70° C.).", "Method B: Rt: 1.04 min m/z: 465.1 (M−H)− Exact mass: 466.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.38 (s, 6H), 3.78 (s, 3H), 7.56 (t, J=9.1 Hz, 1H), 7.66 (s, 1H), 7.99 (ddd, J=9.1, 4.8, 2.8 Hz, 1H), 8.20 (dd, J=5.7, 2.6 Hz, 1H), 8.34 (br.", "s., 1H), 10.64 (br.", "s., 1H).", "Compound 271: 3-Chloro-N-(3-cyano-4-fluorophenyl)-1-methyl-4-{[1-(trifluoro-methyl)cyclopropyl]sulfamoyl}-1H-pyrrole-2-carboxamide Compound 271 was prepared similarly as described for compound 270, using 1-(trifluoromethyl)cyclopropanamine instead of 2,2,2-trifluoro-1,1-dimethyl-ethylamine.", "Method B: Rt: 1.01 min m/z: 463.1 (M−H)− Exact mass: 464.1.Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 209.5° C. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.10-1.25 (m, 4H), 3.78 (s, 3H), 7.56 (t, J=9.1 Hz, 1H), 7.65 (s, 1H), 7.98 (ddd, J=9.1, 4.8, 2.8 Hz, 1H), 8.19 (dd, J=5.8, 2.8 Hz, 1H), 9.01 (br.", "s., 1H), 10.67 (br.", "s., 1H).", "Compound 272: 3-chloro-N-(2-cyano-4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Compound 272 was prepared similarly as described for compound 250, using 6-amino-3-fluoro-2-methyl-benzonitrile instead of 3-bromoaniline.", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 235.1° C. Method B: Rt: 1.05 min m/z: 465.1 (M−H)− Exact mass: 466.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=6.8 Hz, 3H), 2.43 (d, J=2.2 Hz, 3H), 3.81 (s, 3H), 3.91-4.05 (m, 1H), 7.50 (dd, J=8.8, 4.8 Hz, 1H), 7.59 (t, J=9.0 Hz, 1H), 7.70 (s, 1H), 8.49 (d, J=6.6 Hz, 1H), 10.44 (br.", "s., 1H).", "Compound 273: 3-chloro-N-(2-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Compound 273 was prepared similarly as described for compound 250, using 2-amino-5-fluorobenzonitrile instead of 3-bromoaniline.", "Method D: Rt: 1.82 min m/z: 451.0 (M−H)− Exact mass: 452.0.Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 200.7° C. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=6.8 Hz, 3H), 3.81 (s, 3H), 3.91-4.06 (m, 1H), 7.61-7.69 (m, 2H), 7.70 (s, 1H), 7.87-7.95 (m, 1H), 8.50 (d, J=8.6 Hz, 1H), 10.49 (s, 1H).", "Compound 274: 3-chloro-N-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Compound 274 was prepared similarly as described for compound 250, using 4-fluoro-3-(trifluoromethyl)aniline instead of 3-bromoaniline.", "Method B: Rt: 1.15 min m/z: 494.1 (M−H)− Exact mass: 495.0.Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 189.8° C. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=6.8 Hz, 3H), 3.78 (s, 3H), 3.91-4.04 (m, 1H), 7.54 (t, J=9.8 Hz, 1H), 7.68 (s, 1H), 7.91-8.02 (m, 1H), 8.19 (dd, J=6.4, 2.4 Hz, 1H), 8.49 (br.", "s., 1H), 10.67 (s, 1H).", "Compound 275: 3-chloro-N-(2-fluoro-6-methyl-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Compound 275 was prepared similarly as described for compound 250, using 2-fluoro-6-methylaniline instead of 3-bromoaniline.", "Method B: Rt: 0.99 min m/z: 440.1 (M−H)− Exact mass: 441.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.14-1.29 (m, 3H), 2.28 (s, 3H), 3.76 (s, 3H), 3.91-4.03 (m, 1H), 7.08-7.18 (m, 2H), 7.22-7.32 (m, 1H), 7.65 (s, 1H), 8.45 (br.", "s., 1H), 9.85 (s, 1H).", "Compound 276: 3-chloro-N-(3-cyano-2,4-difluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Compound 276 was prepared similarly as described for compound 250, using 3-amino-2,6-difluorobenzonitrile instead of 3-bromoaniline.", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 217.6° C. Method B: Rt: 1.03 min m/z: 469.1 (M−H)− Exact mass: 470.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=6.8 Hz, 3H), 3.79 (s, 3H), 3.91-4.04 (m, 1H), 7.47 (dt, J=8.9, 1.5 Hz, 1H), 7.70 (s, 1H), 8.09 (td, J=9.0, 6.2 Hz, 1H), 8.50 (br.", "s., 1H), 10.36 (br.", "s., 1H).", "Compound 277: 3-chloro-N-(2,3-dichloro-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Compound 277 was prepared similarly as described for compound 250, using 2,3-dichloro-4-fluoroaniline instead of 3-bromoaniline.", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 206.0° C. Method B: Rt: 1.20 min m/z: 496.0 (M−H)− Exact mass: 495.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=6.8 Hz, 3H), 3.81 (s, 3H), 3.91-4.03 (m, 1H), 7.52 (t, J=8.9 Hz, 1H), 7.70 (s, 1H), 7.76 (dd, J=9.1, 5.4 Hz, 1H), 8.49 (br.", "s., 1H), 10.08 (br.", "s., 1H).", "Compound 278: 3-chloro-N-[3-(difluoromethyl)-2,4-difluoro-phenyl]-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Diethylaminosulfur trifluoride (23.4 mL) was added to the solution of 2,6-difluoro-3-nitro-benzaldehyde (18 g, 96.21 mmol) in dichloromethane (180 mL) at −78° C. under N2 atmosphere.", "The mixture was stirred for 1 hour and then warmed to 25° C. for 4 hours.", "The mixture was poured into aqueous NaHCO3/ice and the aqueous phase was extracted twice with ethyl acetate.", "The combined organic layers were dried and concentrated in vacuo, resulting in crude 2-(difluoromethyl)-1,3-difluoro-4-nitro-benzene (15 g).", "2-(difluoromethyl)-1,3-difluoro-4-nitro-benzene (10 g, 47.8 mmol) was stirred in water (100 mL) and ethanol (100 mL).", "Fe (16.0 g, 286.8 mmol) and ammonium chloride (15.34 g, 286.8 mmol) were added at 0° C. The mixture was stirred at 70° C. for 2 hours, filtered off and the filtrate was concentrated in vacuo.", "The residue was dissolved in water (20 mL) and extracted with ethyl acetate (3×50 mL).", "The combined organic layers were washed with brine and dried over Na2SO4.The solvent was removed in vacuo and the obtained residue was dissolved in ethyl acetate (5 mL), and then HCl/ethylacetate (2 mL) was added.", "The mixture was stirred at 20° C. for 20 minutes.", "The volatiles were removed in vacuo, resulting in 3-(difluoromethyl)-2,4-difluoro-aniline hydrochloride (5.1 g).", "Compound 278 was prepared similarly as described for compound 250, using 3-(difluoromethyl)-2,4-difluoro-aniline hydrochloride instead of 3-bromoaniline.", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 189.5° C. Method B: Rt: 1.07 min m/z: 494.1 (M−H)− Exact mass: 495.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=6.8 Hz, 3H), 3.79 (s, 3H), 3.97 (br.", "s., 1H), 7.32 (t, J=9.8 Hz, 1H), 7.35 (t, J=52.0 Hz, 1H), 7.68 (s, 1H), 7.87-7.98 (m, 1H), 8.48 (br.", "s., 1H), 10.19 (br.", "s., 1H).", "Compound 279: 3-chloro-N-[3-(difluoromethyl)-4-fluoro-phenyl]-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Compound 279 was prepared similarly as described for compound 250, using 3-(difluoromethyl)-4-fluoro-aniline instead of 3-bromoaniline.", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 190.4° C. Method B: Rt: 1.06 min m/z: 476.1 (M−H)− Exact mass: 477.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=6.8 Hz, 3H), 3.77 (s, 3H), 3.90-4.06 (m, 1H), 7.24 (t, J=54.4 Hz, 1H), 7.39 (t, J=9.7 Hz, 1H), 7.67 (s, 1H), 7.80-7.88 (m, 1H), 8.01-8.08 (m, 1H), 8.49 (d, J=7.0 Hz, 1H), 10.58 (s, 1H).", "Compound 280: N-(3-bromophenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Compound 280 (344 mg) was prepared similarly as described for compound 229, using 3-bromoaniline instead of 3,4-difluoroaniline.", "Method D: Rt: 2.02 min m/z: 472.0 (M−H)− Exact mass: 473.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (d, J=7.0 Hz, 3H), 3.80 (s, 3H), 3.91-4.04 (m, 1H), 7.27-7.35 (m, 2H), 7.54 (d, J=4.4 Hz, 1H), 7.59-7.65 (m, 1H), 7.96-8.01 (m, 1H), 8.59 (d, J=8.6 Hz, 1H), 10.21 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 216.8° C. Compound 281: N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[1-(trifluoro-methyl)cyclopentyl]sulfamoyl]pyrrole-2-carboxamide A mixture of ethyl 4-chlorosulfonyl-3-fluoro-1-methyl-pyrrole-2-carboxylate (302 mg, 1.04 mmol), 1-(trifluoromethyl)cyclopentanamine (216 mg, 1.4 mmol) NaHCO3 (261 mg, 3.1 mmol) acetonitrile (20 mL) and molecular sieves 4A (1000 mg) was refluxed overnight.", "The reaction mixture was filtered and concentrated.", "The residue was purified by silica gel column chromatography using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated yielding ethyl 3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclopentyl]sulfamoyl]pyrrole-2-carboxylate (60.5 mg) as a light yellow powder.", "Lithium bis(trimethylsilyl)amide in toluene (0.59 mL, 1 M, 0.59 mmol) was added to ethyl 3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclopentyl]sulfamoyl]pyrrole-2-carboxylate (57 mg, 0.148 mmol) and 5-amino-2-fluoro-benzonitrile (26.1 mg, 0.19 mmol) in THF (10 mL) at room temperature under nitrogen.", "The reaction mixture was stirred 1 hour, quenched with NH4Cl (25 mL) solution, diluted with brine (25 mL) and extracted with EtOAc (50 mL).", "The organic layer was dried over magnesium sulphate, filtered and concentrated.", "The residue was purified by silica gel column chromatography using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated.", "The residue was dissolved in hot methanol (10 mL).", "The product crystallised upon addition of water.", "Compound 281 (30.5 mg) was filtered off and dried overnight in vacuo at 50° C. Method D: Rt: 2.02 min m/z: 475.3 (M−H)− Exact mass: 476.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.42-1.54 (m, 2H), 1.58-1.71 (m, 2H), 1.72-1.85 (m, 2H), 2.21-2.32 (m, 2H), 3.81 (s, 3H), 7.50-7.57 (m, 2H), 7.97 (ddd, J=9.2, 4.8, 2.9 Hz, 1H), 8.17 (dd, J=5.8, 2.8 Hz, 1H), 8.32 (s, 1H), 10.33 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 187.0° C. Compound 282: 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Ethyl 4-chlorosulfonyl-1,5-dimethyl-pyrrole-2-carboxylate (600 mg, 2.26 mmol) was dissolved in acetonitrile (4 mL), dried on molecular sieves and NaHCO3 (569 mg, 6.77 mmol) was added.", "(R)-1,1,1-trifluoro-2-propylamine (766 mg, 6.77 mmol) was dissolved in acetonitrile (1 mL) and dried on molecular sieves.", "The two suspensions were combined and heated at 80° C. for 4 hours.", "The reaction mixture was filtered, washed with acetonitrile and evaporated to dryness to afford a yellow sticky powder (730 mg) which was purified using silica gel column chromatography resulting in ethyl 1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (600 mg) as colorless sticky powder.", "Ethyl 1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (402 mg, 1.17 mmol) was dissolved in HOAc (10 mL) and N-Chlorosuccinimide (156.8 mg, 1.17 mmol) was added.", "The reaction mixture was heated at 40° C. over weekend.", "The reaction mixture was evaporated to dryness and the residue was purified using silica gel column chromatography (first ethylacetate in heptane from 0 to 100%, then again using methanol in CH2Cl2 from 0.1 to 0.5%) to afford ethyl 3-chloro-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (177 mg).", "Method D: Rt: 1.89 min m/z: 375.3 (M−H)− Exact mass: 376.0.Lithium bis(trimethylsilyl)amide in toluene (0.934 mL, 1 M, 0.934 mmol) was added to ethyl 3-chloro-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (88 mg, 0.234 mmol) and 5-amino-2-fluoro-benzonitrile (41.3 mg, 0.30 mmol) dissolved in THF (5 mL) and stirred overnight.", "The reaction mixture was quenched with NH4Cl solution (5 mL) and diluted with brine (5 mL) then extracted with EtOAc (20 mL).", "The organic layer was dried over magnesium sulphate, filtered and concentrated.", "The obtained residue was dissolved in DMF (1 mL) and purified by silica gel column chromatography using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated and the residue dissolved in hot methanol (10 mL).", "Water was added until crystallisation began.", "Compound 282 (44 mg) was filtered off and dried overnight in vacuo at 50° C. Method D: Rt: 1.89 min m/z: 465.0 (M−H)− Exact mass: 466.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (d, J=6.8 Hz, 3H), 2.49 (s, 3H), 3.64 (s, 3H), 3.87-4.00 (m, 1H), 7.56 (t, J=9.1 Hz, 1H), 7.98 (ddd, J=9.2, 4.9, 2.6 Hz, 1H), 8.20 (dd, J=5.7, 2.6 Hz, 1H), 8.40 (d, J=9.0 Hz, 1H), 10.71 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 240.0° C. Compound 283: N-(3-cyano-4-fluoro-5-methyl-phenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide 2-fluoro-3-methylbenzonitrile (18 g, 133 mmol) was added to a solution of potassium nitrate (13.5 g, 133 mmol) in sulfuric acid (250 mL) cooled at 0° C., the mixture was allowed to stir at room temperature for 40 minutes.", "The reaction mixture was poured into ice water and the pale yellow precipitate was filtered off and dried in the vacuum oven yielding crude 2-fluoro-3-methyl-5-nitro-benzonitrile (18 g).", "Crude 2-fluoro-3-methyl-5-nitro-benzonitrile (18 g) was stirred in MeOH (210 mL) and water (70 mL).", "Fe powder (16.7 g) and HCl (36 mL, 5 equiv) were added and the mixture was stirred at room temperature for 2 hours.", "The reaction mixture was then filtered through celite and after removal of organic solvent, the mixture was adjusted to pH 9 with saturated solution of sodium carbonate and extracted with CH2Cl2 twice.", "The combined organic layers were dried over sodium sulfate and evaporated to dryness to provide an yellow oil.", "The crude product was purified by column chromatography to provide 5-amino-2-fluoro-3-methyl-benzonitrile (5.1 g) as a pale yellow solid.", "Compound 283 (123 mg) was prepared similarly as described for compound 229, using 5-amino-2-fluoro-3-methyl-benzonitrile instead of 3,4-difluoroaniline.", "Method D: Rt: 1.95 min m/z: 449.3 (M−H)− Exact mass: 450.1.1H NMR (600 MHz, DMSO-d6) δ ppm 1.18 (d, J=7.0 Hz, 3H), 2.30 (d, J=1.8 Hz, 3H), 3.80 (s, 3H), 3.98 (dq, J=15.2, 7.6 Hz, 1H), 7.57 (d, J=4.3 Hz, 1H), 7.87 (dd, J=6.5, 2.3 Hz, 1H), 7.97 (dd, J=5.2, 2.6 Hz, 1H), 8.64 (d, J=8.7 Hz, 1H), 10.31 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 214.8° C. Compound 284: N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[(1S)-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide Compound 284 was prepared similarly as described for compound 281 using (S)-1-trifluoromethyl-propylamine instead of 1-(trifluoromethyl)cyclopentanamine.", "Method D: Rt: 1.92 min m/z: 449.3 (M−H)− Exact mass: 450.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.80 (t, J=7.4 Hz, 3H), 1.43-1.56 (m, 1H), 1.62-1.74 (m, 1H), 3.70-3.79 (m, 1H), 3.80 (s, 3H), 7.50-7.57 (m, 2H), 7.94-7.99 (m, 1H), 8.17 (dd, J=5.7, 2.6 Hz, 1H), 8.58 (d, J=8.6 Hz, 1H), 10.33 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 177.3° C. Compound 285: 3-fluoro-N-(4-fluorophenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Compound 285 (105 mg) was prepared similarly as described for compound 229, using 4-fluoroaniline instead of 3,4-difluoroaniline.", "Method D: Rt: 1.87 min m/z: 410.3 (M−H)− Exact mass: 411.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (d, J=7.0 Hz, 3H), 3.80 (s, 3H), 3.91-4.03 (m, 1H), 7.14-7.22 (m, 2H), 7.51 (d, J=4.4 Hz, 1H), 7.65-7.72 (m, 2H), 8.57 (d, J=8.8 Hz, 1H), 10.12 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 212.9° C. Compound 286: N-[3-(difluoromethyl)-4-fluoro-phenyl]-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Compound 286 (130 mg) was prepared similarly as described for compound 229, using 3-(difluoromethyl)-4-fluoro-aniline instead of 3,4-difluoroaniline.", "Method D: Rt: 1.93 min m/z: 460.0 (M−H)− Exact mass: 461.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (d, J=6.8 Hz, 3H), 3.81 (s, 3H), 3.92-4.03 (m, 1H), 7.07-7.41 (m, 2H), 7.54 (d, J=4.4 Hz, 1H), 7.78-7.84 (m, 1H), 8.01 (dd, J=6.3, 2.5 Hz, 1H), 8.60 (d, J=8.8 Hz, 1H), 10.28 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 198.8° C. Compound 287: N-[3-(difluoromethyl)-2,4-difluoro-phenyl]-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Compound 287 (80 mg) was prepared similarly as described for compound 229, using 3-(difluoromethyl)-2,4-difluoro-aniline instead of 3,4-difluoroaniline.", "Method D: Rt: 1.95 min m/z: 478.3 (M−H)− Exact mass: 479.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=7.0 Hz, 3H), 3.81 (s, 3H), 3.92-4.04 (m, 1H), 7.19-7.48 (m, 2H), 7.56 (d, J=4.6 Hz, 1H), 7.82-7.91 (m, 1H), 8.62 (d, J=8.8 Hz, 1H), 9.84 (s, 1H).", "Compound 288: N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[(1R)-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide Compound 288 was prepared similarly as described for compound 281 using (R)-1-trifluoromethyl-propylamine instead of 1-(trifluoromethyl)cyclopentanamine.", "Method D: Rt: 1.92 min m/z: 449.0 (M−H)− Exact mass: 450.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.80 (t, J=7.3 Hz, 3H), 1.43-1.56 (m, 1H), 1.62-1.74 (m, 1H), 3.70-3.79 (m, 1H), 3.80 (s, 3H), 7.50-7.57 (m, 2H), 7.97 (ddd, J=9.2, 4.8, 2.6 Hz, 1H), 8.17 (dd, J=5.7, 2.6 Hz, 1H), 8.58 (d, J=8.6 Hz, 1H), 10.34 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 175.7° C. Compound 289: 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1S)-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide Methyl 3-chloro-4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate (1000 mg, 3.68 mmol) was dissolved in CH3CN (18 mL) in a pressure tube and this was dried with powdered molecular sieves (4 Å) over a period of 30 minutes.", "Another tube was loaded with (S)-1-trifluoromethyl-propylamine (700.7 mg, 5.51 mmol) and NaHCO3 (926 mg, 11.03 mmol) and this was dispersed in acetonitrile (2 mL) and dried with powdered molecular sieves (4 Å) over a period of 30 minutes.", "This was added to the pressure tube which was flushed with nitrogen, capped and stirred in a heating block at 80° C. for 48 hours and next 1 hour at 125° C. by microwave irradiation.", "The reaction mixture was filtered and concentrated.", "The residue was dissolved in CH2Cl2 (5 mL) filtered and subjected to silica gel column chromatography using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated yielding methyl 3-chloro-1-methyl-4-[[(1S)-1-(trifluoromethyl)propyl]sulfamoyl]pyrrole-2-carboxylate (829 mg) as a white solidified resin.", "Lithium bis(trimethylsilyl)amide in toluene (1.844 mL, 1 M, 1.84 mmol) was added to methyl 3-chloro-1-methyl-4-[[(1S)-1-(trifluoromethyl)propyl]sulfamoyl]pyrrole-2-carboxylate (167.2 mg, 0.461 mmol) and 5-amino-2-fluoro-benzonitrile (81.6 mg, 0.599 mmol) dissolved in THF (2 mL) and stirred overnight.", "The reaction mixture was quenched with NH4Cl solution (5 mL) and diluted with brine (5 mL) then extracted with EtOAc (20 mL).", "The organic layer was dried over magnesium sulphate, filtered and concentrated.", "The residue was purified by column chromatography using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated and the residue dissolved in methanol (10 mL).", "Water was added until crystallisation began.", "Compound 289 (160 mg) was filtered off and dried overnight in vacuo at 50° C. Method D: Rt: 1.92 min m/z: 465.0 (M−H)− Exact mass: 466.0.1H NMR (400 MHz, DMSO-d6) δ ppm 0.81 (t, J=7.4 Hz, 3H), 1.46-1.59 (m, 1H), 1.61-1.73 (m, 1H), 3.72-3.82 (m, 4H), 7.56 (t, J=9.1 Hz, 1H), 7.66 (s, 1H), 7.99 (ddd, J=9.2, 4.9, 2.6 Hz, 1H), 8.20 (dd, J=5.7, 2.6 Hz, 1H), 8.49 (d, J=8.6 Hz, 1H), 10.65 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 184.8° C. Compound 290: 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-1-(trifluoro-methyl)propyl]sulfamoyl]pyrrole-2-carboxamide Compound 290 (133 mg) was prepared similarly as described for compound 289 using (R)-1,1,1-trifluoro-2-butylamine instead of (S)-1-trifluoromethyl-propylamine.", "Method D: Rt: 1.95 min m/z: 465.3 (M−H)− Exact mass: 466.0.1H NMR (400 MHz, DMSO-d6) δ ppm 0.81 (t, J=7.4 Hz, 3H), 1.45-1.59 (m, 1H), 1.61-1.73 (m, 1H), 3.71-3.82 (m, 4H), 7.56 (t, J=9.1 Hz, 1H), 7.66 (s, 1H), 7.99 (ddd, J=9.2, 4.8, 2.6 Hz, 1H), 8.20 (dd, J=5.7, 2.6 Hz, 1H), 8.49 (d, J=8.8 Hz, 1H), 10.65 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 183.8° C. Compound 291: 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-isopropyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Methyl 3-chloro-1H-pyrrole-2-carboxylate (2 g, 12.5 mmol) was dissolved in DMF (20 mL) under N2 atmosphere.", "NaH (60% dispersion in mineral oil) [(601.6 mg, 15.0 mmol) was added portion wise and the mixture was stirred for 10 minutes at room temperature.", "2-iodopropane (1.5 mL, 15.0 mmol) was added dropwise and the mixture was stirred at room temperature for 16 hours.", "The mixture was quenched with water and the mixture was extracted with EtOAc.", "The organic layer was washed with brine, dried (MgSO4), filtered and concentrated in vacuo.", "The residue was purified by silica gel chromatography using gradient eluent Heptane-EtOAc; 100-0->50-50.The product fractions were collected and concentrated in vacuo resulting in methyl 3-chloro-1-isopropyl-pyrrole-2-carboxylate (1.2 g) as an oil.", "Methyl 3-chloro-1-isopropyl-pyrrole-2-carboxylate (1.2 g, 5.95 mmol) was added drop wise to chlorosulfonic acid (1.99 mL, 29.9 mmol) at 0° C. under nitrogen atmosphere.", "The reaction mixture was warmed to room temperature and allowed to stir for 1 hour.", "The resulting mixture was added dropwise to a stirred, temperature controlled ice-water mixture (100 mL) keeping the temperature under 5° C. A white suspension was formed.", "The obtained aqueous suspension was extracted using Me-THF (2×50 mL).", "The combined extracts were washed with Brine and dried on sodium sulphate, filtered and concentrated in vacuo yielding methyl 3-chloro-4-chlorosulfonyl-1-isopropyl-pyrrole-2-carboxylate (1.7 g) which was used as such in the next step.", "Methyl 3-chloro-4-chlorosulfonyl-1-isopropyl-pyrrole-2-carboxylate (1.7 g, 5.66 mmol) was dissolved in hot acetonitrile (3 mL), molecular sieves (˜0.7 g) were added and the reaction mixture was stirred.", "In a separate vessel (R)-1,1,1-trifluoro-2-propylamine (960.7 mg, 8.5 mmol) was dissolved in acetonitrile (2 mL), molecular sieves (˜0.7 g) were added.", "This suspension was added to the reaction mixture and then NaHCO3 (1.43 g, 17.0 mmol) was added.", "The vessel was closed and it was stirred overnight at 80° C. The reaction mixture was filtered and the solids were washed with acetonitrile (2×50 mL).", "The organic fractions were combined and concentrated in vacuo.", "The mixture was concentrated and purified by silica gel chromatography using gradient eluent heptane-EtOAc; 100-0->50-50.The product fractions were combined and concentrated in vacuo resulting in methyl 3-chloro-1-isopropyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (907 mg) as a fluffy solid.", "Methyl 3-chloro-1-isopropyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (450 mg, 1.194 mmol) and 5-amino-2-fluorobenzonitrile 201 mg, 1.43 mmol) was dissolved in THF (dried on molecular sieves) (10.1 mL, 124.7 mmol).", "lithium bis(trimethylsilyl)amide (1M in THF) (3.58 mL, 1 M, 3.583 mmol) was added drop wise and the reaction mixture was stirred for 1 hour at room temperature.", "The mixture was quenched with sat.", "NH4Cl-sol.", "The organic layer was separated, dried (MgSO4), filtered and concentrated in vacuo.", "The product was purified by silica gel chromatography using gradient eluent Heptane-EtOAc; 100-0->50-50.The product fractions were collected and concentrated in vacuo.", "The product was crystallized from 2-propanol, filtered and dried under vacuum to resulting in compound 291 (58 mg) as a pale yellow solid.", "The filtrate was concentrated in vacuo and further purified by preparative HPLC, resulting in more compound 291 (247 mg).", "Method B: Rt: 1.10 min m/z: 479.1 (M−H)− Exact mass: 480.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (d, J=6.8 Hz, 3H) 1.42 (d, J=6.6 Hz, 6H) 4.00-4.09 (m, 1H) 4.71 (quin, J=6.7 Hz, 1H) 7.56 (t, J=9.1 Hz, 1H) 7.78 (s, 1H) 7.95-8.00 (m, 1H) 8.20 (dd, J=5.6, 2.5 Hz, 1H) 8.47 (d, J=8.6 Hz, 1H) 10.91 (s, 1H).", "Compound 292: 3-bromo-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Methyl 3-bromo-1-methyl-pyrrole-2-carboxylate (5 g, 22.93 mmol) was added drop wise to chlorosulfonic acid (13.4 g, 114.7 mmol) at 0° C. The reaction mixture was warmed to room temperature and allowed to stir for 1 hour.", "The resulting mixture was added dropwise to a stirred ice-water mixture (300 mL) keeping the temperature below 5° C. An off white precipitation was formed.", "The solids were filtered and washed with water (20 mL), triturated with diisopropylether and dried in vacuum oven overnight, resulting in methyl 3-bromo-4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate (3.9 g).", "Methyl 3-bromo-4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate (3.9 g, 12.32 mmol) was dissolved in hot acetonitrile (20 mL) in a pressure vessel (100 mL), molecular sieves (10 g) were added and the reaction mixture was stirred.", "In a separate vessel (R)-1,1,1-trifluoro-2-propylamine (2.09 g, 18.5 mmol) was dissolved in acetonitrile (20 mL), molecular sieves (5 g) were added.", "This suspension was added to the reaction mixture and then NaHCO3 (3.1 g, 36.96 mmol) was added.", "The vessel was closed and it was stirred overnight at 80° C. The reaction mixture was filtered and the volatiles were removed under reduced pressure.", "The residue was purified on silica using a heptane to EtOAc gradient.", "The fractions containing the product were evaporated to dryness resulting in methyl 3-bromo-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methylethyl]sulfamoyl]pyrrole-2-carboxylate (4.24 g) as a white powder.", "Methyl 3-bromo-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (150 mg, 0.38 mmol) and 5-amino-2-fluorobenzonitrile (69.6 mg, 0.5 mmol) were dissolved in dry THF (5 mL).", "Lithium bis(trimethylsilyl)amide (1M in THF) (1.14 mL, 1 M, 1.14 mmol) was added and the reaction mixture was stirred overnight at room temperature.", "The reaction mixture was quenched with sat.", "NH4Cl (5 mL).", "The organic layer was removed and the aqueous layer extracted with CH2Cl2 (2×5 mL).", "The combined organic layers were evaporated to dryness and the residue was purified on silica using a heptane to EtOAc gradient resulting in compound 292 (146 mg) as a light pink powder after trituration in CH2Cl2/diisopropylether.", "Method B: Rt: 1.00 min m/z: 496.9 (M−H)− Exact mass: 498.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.20 (d, J=7.0 Hz, 3H), 3.77 (s, 3H), 4.01 (br.", "s., 1H), 7.57 (t, J=9.1 Hz, 1H), 7.71 (s, 1H), 7.98 (ddd, J=9.2, 4.9, 2.6 Hz, 1H), 8.19 (dd, J=5.7, 2.6 Hz, 1H), 8.44 (br.", "s., 1H), 10.74 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 189.2° C. Compound 293: 3-cyano-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide A microwave vial was charged with compound 292 (94 mg, 0.189 mmol) and zinc cyanide (13.6 mg, 0.113 mmol) in DMF (0.8 mL).", "The mixture was purged with N2 for 5 minutes.", "tetrakis(triphenylphosphine)palladium(0) (10.9 mg, 0.00945 mmol) was added and the vial capped.", "The mixture was heated at 160° C. for 30 minutes by microwave irradiation.", "The mixture was concentrated in vacuo.", "A purification was performed via Preparative HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm, Mobile phase: 0.25% NH4HCO3 solution in water, CH3CN).", "The product fractions were collected and concentrated in vacuo.", "The residue was dissolved in MeOH and concentrated again resulting in compound 293 (8.3 mg) as a white solid.", "Method B: Rt: 0.97 min m/z: 442.1 (M−H)− Exact mass: 443.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.22 (d, J=6.8 Hz, 3H) 3.85 (s, 3H) 4.01-4.12 (m, 1H) 7.60 (t, J=9.0 Hz, 1H) 7.82 (s, 1H) 7.95 (ddd, J=9.1, 4.8, 2.8 Hz, 1H) 8.19 (dd, J=5.7, 2.6 Hz, 1H) 8.80 (br.", "s., 1H) 11.18 (br.", "s., 1H).", "Compound 294: N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-1-methylpropyl]-sulfamoyl]pyrrole-2-carboxamide 5-[(3-cyano-4-fluoro-phenyl)carbamoyl]-1-methyl-pyrrole-3-sulfonyl chloride (200 mg, 0.59 mmol) was dissolved in acetonitrile (6 mL) in a pressure tube and this was dried with powdered molecular sieves (4 Å) over a period of 30 minutes.", "Another tube was loaded with (R)-(−)-2-aminobutane (64.2 mg, 0.88 mmol) and NaHCO3 (245.81 mg, 2.93 mmol) and this was dispersed in acetonitrile (4 mL) and dried with powdered molecular sieves (4 Å) over a period of 30 minutes.", "This was added to the pressure tube which was flushed with nitrogen, capped and stirred in a heating block at 80° C. for 2 hours.", "Then the reaction mixture was filtered over a small path of dicalite and rinsed using dichloromethane (50 mL).", "The filtrate was concentrated in vacuo and the obtained residue was purified using silica gel column chromatography (gradient elution: EtOAc-heptane 0:100 to 100:0), resulting in compound 294 (136 mg).", "Method B: Rt: 1.00 min m/z: 377.1 (M−H)− Exact mass: 378.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.76 (t, J=7.4 Hz, 3H), 0.91-0.99 (m, 3H), 1.29-1.41 (m, 2H), 3.01-3.15 (m, 1H), 3.92 (s, 3H), 7.17 (d, J=7.5 Hz, 1H), 7.35 (d, J=1.8 Hz, 1H), 7.49-7.59 (m, 2H), 8.02 (ddd, J=9.2, 4.9, 2.9 Hz, 1H), 8.19-8.25 (m, 1H), 10.36 (s, 1H).", "Compound 295: 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-1-methyl-propyl]sulfamoyl]pyrrole-2-carboxamide Compound 295 (515 mg) was prepared similarly as described for compound 289 using (S)-(+)-2-aminobutane instead of (S)-1-trifluoromethyl-propylamine, stirring at 70° C. for 2 hours for the formation of methyl 3-chloro-1-methyl-4-[[(1R)-1-methylpropyl]sulfamoyl]pyrrole-2-carboxylate instead of 80° C. for 48 hours as described for methyl 3-chloro-1-methyl-4-[[(1S)-1-(trifluoromethyl)propyl]sulfamoyl]pyrrole-2-carboxylate.", "Method B: Rt: 1.01 min m/z: 411.1 (M−H)− Exact mass: 412.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.79 (t, J=7.4 Hz, 3H), 1.00 (d, J=6.6 Hz, 3H), 1.31-1.45 (m, 2H), 3.03-3.18 (m, 1H), 3.77 (s, 3H), 7.42 (d, J=7.9 Hz, 1H), 7.55 (t, J=9.1 Hz, 1H), 7.60 (s, 1H), 7.98 (ddd, J=9.1, 4.9, 2.8 Hz, 1H), 8.19 (dd, J=5.8, 2.8 Hz, 1H), 10.64 (br.", "s., 1H).", "Compound 296: N-(3-cyano-4-fluoro-phenyl)-4-[(3-hydroxy-1,1-dimethyl-propyl)sulfamoyl]-1-methyl-pyrrole-2-carboxamide Compound 296 was prepared similarly as described for compound 294 using 3-amino-3-methylbutan-1-ol instead of (R)-(−)-2-aminobutane.", "Method B: Rt: 0.85 min m/z: 407.1 (M−H)− Exact mass: 408.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.13-1.20 (m, 6H), 1.67 (t, J=7.0 Hz, 2H), 3.48 (t, J=6.9 Hz, 2H), 3.91 (s, 3H), 4.45 (br.", "s., 1H), 7.07 (br.", "s., 1H), 7.34 (d, J=2.0 Hz, 1H), 7.49-7.57 (m, 2H), 8.02 (ddd, J=9.2, 5.0, 2.8 Hz, 1H), 8.22 (dd, J=5.8, 2.8 Hz, 1H), 10.25-10.51 (m, 1H).", "Synthesis of (2S)-3,3-difluorobutan-2-amine hydrochloride (S)-2-((tert-butoxycarbonyl)amino)propanoic acid (39 g, 206 mmol), N,O-dimethyl-hydroxylamine hydrochloride (24 g, 246 mmol), HATU (117 g, 308 mmol) and N,N-diisopropylethylamine (66.3 g, 513 mmol) were dissolved in DMF (500 mL) and stirred at room temperature for 16 hours.", "The reaction mixture was poured into water (500 mL) and the formed precipitate was filtered off.", "The filter cake was washed with water (1 L) and dried to give tert-butyl N-[(1S)-2-[methoxy(methyl)amino]-1-methyl-2-oxo-ethyl]carbamate (36 g) as a white powder.", "tert-butyl N-[(1S)-2-[methoxy(methyl)amino]-1-methyl-2-oxo-ethyl]carbamate (35 g, 151 mmol) was dissolved in THF (500 mL) and cooled to 0° C. Methylmagnesium bromide (3.0 M in diethyl ether, 140 mL) was added and the reaction mixture was stirred 16 hours at room temperature.", "The reaction mixture was poured into water (100 mL) and evaporated to dryness.", "The residue was dissolved in EtOAc, washed with water, dried over Na2SO4, filtered and evaporated to dryness yielding tert-butyl N-[1S)-1-methyl-2-oxo-propyl]carbamate (22 g) as a white powder.", "To a cooled (−78° C.) solution of tert-butyl N-[(1S)-1-methyl-2-oxo-propyl]carbamate (12 g, 64.1 mmol) in CH2Cl2 (200 mL) bis(2-methoxyethyl)-aminosulfur trifluoride (18.9 g, 117.5 mmol) was added.", "The reaction mixture was allowed to warm to room temperature and stirred overnight.", "The reaction mixture was poured into water and extracted with CH2Cl2.The organic layer was washed with water, dried over Na2SO4, filtered and evaporated to dryness.", "The obtained residue was purified by silica gel chromatography yielding tert-butyl N-[(1S)-2,2-difluoro-1-methyl-propyl]carbamate (5.8 g) as a pale yellow solid.", "Tert-butyl N-[(1S)-2,2-difluoro-1-methyl-propyl]carbamate (5.8 g, 27.7 mmol) was dissolved in EtOAc (100 mL).", "HCl (g) was bubbled through for 30 minutes and then the volatiles were removed under reduced pressure yielding (2S)-3,3-difluorobutan-2-amine hydrochloride (3.8 g)1H NMR (400 MHz, DMSO-d6) δ ppm 8.69 (br.", "s., 3H), 3.76-3.63 (m, 1H), 1.72 (t, J=19.7 Hz, 3H), 1.28 (d, J=6.8 Hz, 3H).", "Compound 297: N-(3-cyano-4-fluoro-phenyl)-4-[[(1S)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-1-methyl-pyrrole-2-carboxamide Compound 297 was prepared similarly as described for compound 294 using (2S)-3,3-difluorobutan-2-amine hydrochloride instead of (R)-(−)-2-aminobutane.", "Method D: Rt: 1.79 min m/z: 413.0 (M−H)− Exact mass: 414.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.97 (d, J=6.8 Hz, 3H), 1.57 (t, J=19.1 Hz, 3H), 3.42-3.56 (m, 1H), 3.93 (s, 3H), 7.36 (d, J=1.8 Hz, 1H), 7.53 (t, J=9.2 Hz, 1H), 7.63 (d, J=1.5 Hz, 1H), 7.78 (d, J=9.0 Hz, 1H), 8.01 (ddd, J=9.2, 4.8, 2.9 Hz, 1H), 8.22 (dd, J=5.8, 2.8 Hz, 1H), 10.36 (s, 1H).", "Synthesis of (2R)-3,3-difluorobutan-2-amine (R)-2-((tert-butoxycarbonyl)amino)propanoic acid (30 g, 159 mmol), N,O-dimethyl-hydroxylamine hydrochloride (17.5 g, 178 mmol), HATU (74 g, 195 mmol) and N,N-diisopropylethylamine (30 g, 232 mmol) were dissolved in DMF (300 mL) and stirred at room temperature for 15 hours.", "The reaction mixture was concentrated under vacuum and the residue was dissolved in CH2Cl2 (500 mL) and washed with brine (3×200 mL).", "The organic layer was dried over Na2SO4 and concentrated in vacuo.", "The residue was purified via silica gel chromatography using petroleum ether: EtOAc 2:1 as eluent yielding tert-butyl N-[(1R)-2-[methoxy(methyl)amino]-1-methyl-2-oxo-ethyl]carbamate (28.9 g).", "Tert-butyl N-[(1R)-2-[methoxy(methyl)amino]-1-methyl-2-oxo-ethyl]carbamate was dissolved in THF (300 mL) and cooled to 0° C. Methylmagnesium bromide 3.0 m in diethyl ether (85 mL, 255 mmol) was added drop wise and the reaction mixture was stirred 15 hours at room temperature.", "The reaction mixture was quenched with sat.", "NH4Cl and extracted with CH2Cl2 (3×100 mL).", "The combined organic layers were dried over Na2SO4, filtered and evaporated to dryness.", "The obtained residue was purified via silica gel chromatography yielding tert-butyl N-[(1R)-1-methyl-2-oxo-propyl]carbamate (18.9 g).", "To a cooled (−78° C.) solution of tert-butyl N-[(1R)-1-methyl-2-oxo-propyl]carbamate (10 g, 53.4 mmol) in CH2Cl2 (200 mL) bis(2-methoxyethyl)aminosulfur trifluoride (18.9 g, 117.5 mmol) was added drop wise and stirring was continued for 2 hours at −78° C. The reaction mixture was allowed to warm to room temperature and stirred overnight.", "The reaction mixture was quenched with sat.", "NaHCO3 and extracted with EtOAc.", "The combined organic layers were washed with brine, dried over MgSO4, filtered and evaporated to dryness.", "The residue was purified by silica gel chromatography using a gradient from petroleum ether to petroleum ether:EtOAc 1:1 yielding tert-butyl N-[(1R)-2,2-difluoro-1-methyl-propyl]carbamate (6.77 g).", "Tert-butyl N-[(1R)-2,2-difluoro-1-methyl-propyl]carbamate (6.77 g) was dissolved in EtOAc (50 mL).", "HCl in EtOAc was added at 0° C. and the reaction mixture was stirred for 4 hours at room temperature.", "The formed precipitate was filtered off and dried under high vacuum yielding (2R)-3,3-difluorobutan-2-amine hydrochloride (3.5 g).", "Compound 298: N-(3-cyano-4-fluoro-phenyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]-sulfamoyl]-1-methyl-pyrrole-2-carboxamide Compound 298 was prepared similarly as described for compound 294 using (2R)-3,3-difluorobutan-2-amine hydrochloride instead of (R)-(−)-2-aminobutane.", "Method D: Rt: 1.79 min m/z: 413.0 (M−H)− Exact mass: 414.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.97 (d, J=7.0 Hz, 3H), 1.57 (t, J=19.1 Hz, 3H), 3.43-3.57 (m, 1H), 3.93 (s, 3H), 7.36 (d, J=2.0 Hz, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.63 (d, J=1.5 Hz, 1H), 7.78 (d, J=9.0 Hz, 1H), 8.01 (ddd, J=9.2, 4.8, 2.9 Hz, 1H), 8.22 (dd, J=5.8, 2.8 Hz, 1H), 10.36 (s, 1H).", "Compound 299: N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Br2 (510 mg, 3.191 mmol) dissolved in HOAc (20 mL) was added to ethyl 3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (1050 mg, 3.03 mmol) and the solution was refluxed for 1 hour.", "More Br2 (0.25 equiv) was added and the solution was refluxed for 1 hour more.", "More Br2 (0.3 equiv) was added and the reaction mixture was allowed to reach room temperature overnight.", "The reaction mixture was concentrated and the obtained residue was dissolved in EtOAc (50 mL) washed with NaHCO3 solution, dried over magnesium sulphate, filtered and concentrated, resulting in ethyl 5-bromo-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (1.19 g) as a white powder.", "Method D: Rt: 1.92 min m/z: 423.2 (M−H)− Exact mass: 424.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.19 (d, J=7.0 Hz, 3H), 1.28 (t, J=7.2 Hz, 3H), 3.87 (s, 3H), 3.94-4.07 (m, 1H), 4.28 (q, J=7.0 Hz, 2H), 8.88 (d, J=8.8 Hz, 1H).", "A solution ethyl 5-bromo-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (963 mg, 2.265 mmol), tetraethyltin (852.8 mg, 4.53 mmol) in DMF (7 mL), was flushed with nitrogen during 5 minutes.", "Tetrakis(triphenylphosphine)palladium(0) (261.7 mg, 0.226 mmol) was added and the reaction mixture was heated at 140° C. during 30 minutes by microwave irradiation.", "The reaction mixture was concentrated and the obtained residue was purified by silica gel column chromatography using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated yielding ethyl 3-fluoro-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (769 mg) as a white fluffy powder.", "Method D: Rt: 1.89 min m/z: 359.3 (M−H)− Exact mass: 360.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.14 (d, J=6.8 Hz, 3H), 1.27 (t, J=7.2 Hz, 3H), 2.42 (s, 3H), 3.76 (s, 3H), 3.86-3.98 (m, 1H), 4.26 (q, J=7.0 Hz, 2H), 8.54 (d, J=8.8 Hz, 1H).", "Lithium bis(trimethylsilyl)amide in toluene (1.66 mL, 1 M, 1.66 mmol) was added to ethyl 3-fluoro-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (149.6 mg, 0.415 mmol) and 5-amino-2-fluoro-benzonitrile (73.5 mg, 0.54 mmol) dissolved in THF (2 mL) and stirred overnight.", "The reaction mixture was quenched with NH4Cl solution (5 mL) and diluted with brine (5 mL) then extracted with EtOAc (20 mL).", "The organic layer was dried over magnesium sulphate, filtered and concentrated.", "The residue was dissolved in DMF (1 mL) and purified by silica gel column chromatography using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated and the residue dissolved in methanol (2 mL).", "Water was added until crystallisation began.", "The powder was filtered off and dried overnight in vacuo at 50° C., resulting in compound 299 (76 mg).", "Method D: Rt: 1.88 min m/z: 449.1 (M−H)− Exact mass: 450.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (d, J=6.8 Hz, 3H), 2.44 (s, 3H), 3.70 (s, 3H), 3.85-3.99 (m, 1H), 7.53 (t, J=9.1 Hz, 1H), 7.95 (ddd, J=9.2, 4.8, 2.9 Hz, 1H), 8.17 (dd, J=5.7, 2.6 Hz, 1H), 8.55 (d, J=8.8 Hz, 1H), 10.35 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 177.5° C. Compound 300: 5-bromo-3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Compound 199 (1100 mg, 2.43 mmol), DMF (15 mL), N-bromosuccinimide (449.8 mg, 2.5 mmol) were stirred at room temperature for 64 hours.", "The reaction mixture was poured into water (150 mL).", "The pink solids were filtered, washed with water and purified using silica gel column chromatography (ethyl acetate in heptane from 0 to 40%) resulting in compound 300 (348 mg).", "Method B: Rt: 1.07 min m/z: 530.9 (M−H)− Exact mass: 531.9.1H NMR (400 MHz, DMSO-d6) δ ppm 1.20 (d, J=6.8 Hz, 3H), 3.73 (s, 3H), 3.89-4.09 (m, 1H), 7.57 (t, J=9.1 Hz, 1H), 7.97 (ddd, J=9.1, 4.8, 2.8 Hz, 1H), 8.20 (dd, J=5.7, 2.6 Hz, 1H), 8.77 (br.", "s., 1H), 10.88 (br.", "s., 1H).", "Compound 301: 5-bromo-N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide A mixture of ethyl 5-bromo-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (174 mg, 0.409 mmol), Lithium hydroxide (29.4 mg, 1.23 mmol), THF (20 mL) and water (distilled, 20 mL) was stirred overnight.", "More LiOH was added (3 equiv) and the reaction mixture was stirred for 4 hours.", "The reaction mixture was concentrated, the obtained residue dissolved in water (50 mL) and the solution was neutralised with HCl (1 M in H2O).", "The formed white powder was filtered off and dried in vacuo at 50° C., resulting in 5-bromo-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid (111 mg).", "Method D: Rt: 1.05 min m/z: 397.0 (M−H)− Exact mass: 397.9.5-bromo-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid (106.9 mg, 0.269 mmol), HATU (127.9 mg, 0.336 mmol) and 5-amino-2-fluoro-benzonitrile (73.3 mg, 0.538 mmol) were dissolved in DMF (1 mL), Et3N (0.112 mL, 0.808 mmol) was added and the reaction mixture was stirred over weekend at 55° C. The solution was subjected to silica gel column chromatography using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated.", "The residue was dissolved in methanol (2 mL).", "Water was added until crystallisation began.", "The white powder was filtered off and dried overnight in vacuo at 50° C., resulting in compound 301 (54 mg).", "Method D: Rt: 1.99 min m/z: 515.2 (M−H)− Exact mass: 516.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.22 (d, J=7.0 Hz, 3H), 3.80 (s, 3H), 3.95-4.07 (m, 1H), 7.55 (t, J=9.1 Hz, 1H), 7.95 (ddd, J=9.2, 4.8, 2.9 Hz, 1H), 8.17 (dd, J=5.7, 2.6 Hz, 1H), 8.91 (d, J=8.8 Hz, 1H), 10.55 (s, 1H).", "Compound 302: 3-chloro-N-(3-cyano-4-fluoro-phenyl)-5-cyclopropyl-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Compound 300 (130 mg, 0.24 mmol) and potassium cyclopropyltrifluoroborate (54.3 mg, 0.37 mmol) were dissolved in dimethoxyethane (1.5 mL) and distilled water (0.4 mL).", "The mixture was degassed with N2 for 5 minutes.", "Cs2CO3 (239 mg, 0.73 mmol) was added and the mixture was degassed with N2.Tetrakis(triphenylphosphine)palladium(0) (28.3 mg, 0.024 mmol) was added and the mixture was degassed with N2.The vial was capped and the mixture was heated at 90° C. for 30 minutes under microwave irradiation, next at 120° C. for 30 minutes under microwave irradiation and at 140° C. in MW for 30 minutes under microwave irradiation.", "The mixture was cooled and EtOAc was added.", "The organic layer was separated.", "The water layer was made acidic with HCl (1M) and extracted with ethyl acetate (5 mL), The combined organic layers were dried (MgSO4), filtered and concentrated in vacuo.", "The product was purified using silica gel column chromatography using gradient eluent Heptane-EtOAc; 100-0->0-50 and further via preparative HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm, Mobile phase: 0.25% NH4HCO3 solution in water, CH3CN), resulting in compound 302 (10 mg).", "Method B: Rt: 1.10 min m/z: 491.0 (M−H)− Exact mass: 492.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.73-0.91 (m, 2H), 1.03-1.15 (m, 2H), 1.22 (d, J=6.8 Hz, 3H), 1.72-1.83 (m, 1H), 3.74 (s, 3H), 3.93-4.09 (m, 1H), 7.56 (t, J=9.1 Hz, 1H), 7.97 (ddd, J=9.1, 4.8, 2.8 Hz, 1H), 8.19 (dd, J=5.8, 2.8 Hz, 1H), 8.29 (br.", "s., 1H), 10.73 (br.", "s., 1H).", "Compound 303: N-(3-cyano-4-fluoro-phenyl)-3-isopropyl-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide A microwave vial was charged with methyl 3-bromo-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (500 mg, 1.27 mmol) and potassium isopropenyltrifluoroborate (291 mg, 1.9 mmol).", "Toluene (6.5 mL) and distilled water, (0.65 mL) were added and the mixture was purged with N2 for 5 minutes.", "Pd(OAc)2 (57.1 mg, 0.254 mmol) and butyldi-1-adamantylphosphine (137 mg, 0.382 mmol) were added under N2 and then Cs2CO3 (1243 mg, 3.82 mmol) was added.", "The vial was capped and the mixture was heated at 110° C. for 16 hour.", "The mixture was cooled and Me-THF was added.", "The organic layer was separated, dried (MgSO4), filtered and concentrated in vacuo.", "The residue was purified by silica gel column chromatography using gradient eluent Heptane-EtOAc; 100-0 to 70-30.The product fractions were collected and concentrated in vacuo resulting in methyl 3-isopropenyl-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (350 mg) as a semi solid.", "Methyl 3-isopropenyl-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (350 mg, 0.988 mmol) was dissolved in THF (50 mL), Pd/C (10%) (158 mg) was added under N2-atmosphere and the reaction mixture was stirred under Hz-atmosphere until 1 eq.", "H2 was absorbed.", "The catalyst was removed by filtration over dicalite under nitrogen atmosphere, and the solvent was removed in vacuo, resulting in crude methyl 3-isopropyl-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (352 mg).", "Methyl 3-isopropyl-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (175 mg, 0.491 mmol) and 5-amino-2-fluorobenzonitrile (89.61 mg, 0.638 mmol) were dissolved in THF (3.9 mL) dried on molecular sieves.", "Lithium bis(trimethylsilyl)amide (1M in THF, 1.5 mL, 1.5 mmol) was added drop wise and the reaction mixture was stirred 1 hour at room temperature.", "The mixture was quenched with sat.", "NH4Cl-sol.", "The organic layer was separated, dried (MgSO4), filtered and concentrated in vacuo.", "The product was purified by silica gel column chromatography using gradient eluent Heptane-EtOAc; 100-0 to 50-50 and further by prep HPLC (Stationary phase: RP)(Bridge Prep C18 OBD-10 μm, 30×150 mm, Mobile phase: 0.25% NH4HCO3 solution in water, CH3CN).", "The product fractions were collected and concentrated in vacuo.", "The residue was dissolved in MeOH and concentrated in vacuo again resulting in compound 303 (77 mg) as a light yellow solid.", "Method B: Rt: 1.06 min m/z: 459.1 (M−H)− Exact mass: 460.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.16 (d, J=6.8 Hz, 3H) 1.18-1.30 (m, 6H) 3.32-3.41 (m, 1H) 3.64 (s, 3H) 3.75-3.90 (m, 1H) 7.39 (s, 1H) 7.56 (t, J=9.1 Hz, 1H) 7.90-8.02 (m, 1H) 8.12-8.25 (m, 2H) 10.81 (s, 1H).", "Compound 304: N-(3-cyano-4-fluoro-phenyl)-5-cyclopropyl-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Nitrogen was flushed through a mixture of compound 301 (44.4 mg, 0.086 mmol) potassium cyclopropyltrifluoroborate (38.3 mg, 0.26 mmol) Cs2CO3 (84 mg, 0.26 mmol) in dimethoxyethane (2 mL) and distilled water (0.2 mL) during 5 minutes.", "tetrakis(triphenylphosphine)palladium(0) (19.9 mg, 0.0172 mmol) was added and the reaction mixture was heated at 140° C. during 30 minutes.", "The reaction mixture was concentrated.", "The residue was dissolved in EtOAc (10 mL) and water (5 mL) The organic layer was dried over magnesium sulphate, filtered and concentrated.", "The residue was subjected to silica gel column chromatography using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated and the residue was dissolved in methanol (2 mL).", "Water was added until crystallisation began.", "The white powder was filtered off and dried in vacuo at 50° C., resulting in compound 304 (21 mg).", "Method D: Rt: 1.98 min m/z: 475.1 (M−H)− Exact mass: 476.1.1H NMR (400 MHz, DMSO-d6) δ ppm 0.82-0.91 (m, 2H), 1.04-1.10 (m, 2H), 1.23 (d, J=7.0 Hz, 3H), 1.71-1.81 (m, 1H), 3.81 (s, 3H), 3.90-4.03 (m, 1H), 7.54 (t, J=9.1 Hz, 1H), 7.95 (ddd, J=9.2, 4.8, 2.9 Hz, 1H), 8.17 (dd, J=5.7, 2.6 Hz, 1H), 8.47 (d, J=8.4 Hz, 1H), 10.37 (s, 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 161.4° C. Compound 305: 3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-cyclopropyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide A flask (250 mL) was charged with methyl 3-chloro-1H-pyrrole-2-carboxylate (2 g, 12.53 mmol), cyclopropylboronic acid (2.153 g, 25.07 mmol), Na2CO3 (2.66 g, 25.07 mmol) in dichloroethane (50 mL).", "2,2′-bipyridine (1.98 g, 12.53 mmol) and copper(II) acetate (2.3 g, 12.53 mmol) were added and the mixture was vigourously stirred on air and heated at 70° C. for 2 hours.", "The mixture was cooled and washed with water/NH4OH.", "The organic layer was separated, dried (MgSO4), filtered and concentrated in vacuo.", "The residue was purified by silica gel chromatography using gradient eluent Heptane-EtOAc; 100-0->70-30.The product fractions were collected and concentrated in vacuo resulting in methyl 3-chloro-1-cyclopropyl-pyrrole-2-carboxylate (1.15 g) as a yellow oil.", "Chlorosulfonic acid (0.46 mL, 6.91 mmol) dissolved in dichloromethane (1 mL) was added to methyl 3-chloro-1-cyclopropyl-pyrrole-2-carboxylate (1.15 g, 5.76 mmol) in CH2Cl2 (17.7 mL, 275.9 mmol) in an ice bath and stirred 30 minutes.", "The reaction was further stirred at room temperature for 1 hour, the precipitate was filtered off washed with diisopropylether and used as such in the next step (0.7 g after drying in vacuo).", "The precipatate (0.7 g) was added to SOCl2 (0.7 g, 2.503 mmol) and the mixture was stirred at 80° C. for 30 minutes.", "The mixture was cooled and stirred at room temperature for 16 hours and concentrated in vacuo.", "To the residue ice was added and the mixture was extracted with Me-THF.", "The organic layer was separated, dried (MgSO4), filtered and concentrated in vacuo.", "The residue was purified by silica gel chromatography using gradient eluent Heptane-EtOAc; 100-0->70-30.The product fractions were collected and concentrated in vacuo resulting in methyl 3-chloro-4-chlorosulfonyl-1-cyclopropyl-pyrrole-2-carboxylate (359 mg) as an oil which solidified on standing.", "Methyl 3-chloro-4-chlorosulfonyl-1-cyclopropyl-pyrrole-2-carboxylate (359 mg, 1.20 mmol) was dissolved in hot acetonitrile (3 mL), molecular sieves (about 0.7 g) were added and the reaction mixture was stirred.", "In a separate vessel (R)-1,1,1-trifluoro-2-propylamine (204.2 mg, 1.81 mmol) was dissolved in acetonitrile (2 mL), molecular sieves (about 0.7 g) was added.", "This suspension was added to the reaction mixture and then NaHCO3 (303.5 mg, 3.61 mmol) was added.", "The vessel was closed and it was stirred overnight at 80° C. The reaction mixture was filtered and the solids were washed with acetonitrile (2×50 mL).", "The organic fractions were combined and concentrated in vacuo.", "The mixture was concentrated and purified by silica gel chromatography (solid phase, 40 g) using gradient eluent heptane-EtOAc; 100-0->50-50.The product fractions were combined and concentrated in vacuo to resulting in methyl 3-chloro-1-cyclopropyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (281 mg) as an oil which solidified on standing.", "Methyl 3-chloro-1-cyclopropyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (100 mg, 0.267 mmol) and 5-amino-2-fluorobenzonitrile (48.681 mg, 0.347 mmol) were dissolved in THF (2.1 mL, 25.8 mmol).", "Lithium bis(trimethylsilyl)amide (1M in THF) (0.8 mL, 1 M, 0.8 mmol) was added dropwise at room temperature.", "The mixture was stirred at room temperature for 1 hour.", "The mixture was quenched with sat.", "NH4Cl-sol.", "The organic layer was separated, dried (MgSO4), filtered and concentrated in vacuo.", "A purification was performed via Preparative HPLC (Stationary phase: RP XBridge Prep C18 OBD-10 μm, 30×150 mm, Mobile phase: 0.25% NH4HCO3 solution in water, CH3CN).", "The product fractions were collected and concentrated in vacuo.", "The residue was dissolved in MeOH and concentrated in vacuo again to obtain compound 305 (80 mg) as a white solid.", "Method B: Rt: 1.06 min m/z: 477.0 (M−H)− Exact mass: 478.0.1H NMR (400 MHz, DMSO-d6) δ ppm 0.85-1.05 (m, 4H), 1.17 (d, J=7.0 Hz, 3H), 3.61-3.76 (m, 1H), 3.93-4.12 (m, 1H), 7.53-7.60 (m, 2H), 7.95-6 8.01 (m, 1H), 8.17-8.23 (m, 1H), 8.49 (d, J=8.6 Hz, 1H), 10.86 (s, 1H).", "Compound 306:3-chloro-N-(3-cyano-4-fluoro-phenyl)-1-methyl-4-[(3-methyloxetan-3-yl)sulfamoyl]pyrrole-2-carboxamide Compound 306 (179 mg) was prepared in two steps from methyl 3-chloro-4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate similarly as described for compound 269, using 3 equiv 3-methyl-3-oxetanamine, instead of 1.5 equiv isopropylamine in the first step.", "Method B: Rt: 0.86 min m/z: 425.1 (M−H)− Exact mass: 426.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.53 (s, 3H), 3.77 (s, 3H), 4.15 (d, J=6.6 Hz, 2H), 4.66 (d, J=5.9 Hz, 2H), 7.55 (t, J=9.1 Hz, 1H), 7.66 (s, 1H), 7.78-8.76 (m, 1H), 7.98 (ddd, J=9.2, 4.8, 2.9 Hz, 1H), 8.19 (dd, J=5.8, 2.8 Hz, 1H), 10.65 (br.", "s., 1H).", "Compound 307: 3-chloro-N-(3-cyano-4-fluoro-phenyl)-4-(cyclopentylsulfamoyl)-1-methyl-pyrrole-2-carboxamide Compound 307 (241 mg) was prepared in two steps from methyl 3-chloro-4-chlorosulfonyl-1-methyl-pyrrole-2-carboxylate similarly as described for compound 269, using 3 equiv cyclopentylamine, instead of 1.5 equiv isopropylamine in the first step.", "Method B: Rt: 1.05 min m/z: 423.1 (M−H)− Exact mass: 424.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.34-1.51 (m, 4H), 1.51-1.77 (m, 4H), 3.41-3.52 (m, 1H), 3.77 (s, 3H), 7.52-7.59 (m, 2H), 7.61 (br.", "s, 1H), 7.91-8.07 (m, 1H), 8.14-8.27 (m, 1H), 10.65 (br.", "s., 1H).", "Compound 308: 3-bromo-N-(4-fluoro-3-methyl-phenyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Compound 308 can be prepared similarly as described for compound 292, using 4-fluoro-3-methyl-aniline instead of 5-amino-2-fluorobenzonitrile.", "Method B: Rt: 1.07 min m/z: 486.0 (M−H)− Exact mass: 487.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.20 (d, J=6.8 Hz, 3H), 2.23 (d, J=1.8 Hz, 3H), 3.75 (s, 3H), 3.93-4.07 (m, 1H), 7.13 (t, J=9.1 Hz, 1H), 7.47-7.55 (m, 1H), 7.59-7.65 (m, 1H), 7.67 (s, 1H), 8.39 (br.", "s., 1H), 10.36 (s, 1H).", "Compound 309: N-(3-cyano-4-fluoro-phenyl)-3-fluoro-5-(methoxymethyl)-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Nitrogen was bubbled through a mixture of compound 301 (prepared similarly as described in the synthesis of 301, but on a larger scale, 100.1 mg, 0.194 mmol) potassium trifluoro(methoxymethyl)borate (88.6 mg, 0.58 mmol), Cs2CO3 (189.9 mg, 0.58 mmol), DME (3 mL, 29.0 mmol), water (distilled, 0.25 mL) during 5 minutes.", "Then tetrakis(triphenylphosphine)palladium(0) (44.9 mg, 0.039 mmol) was added and the reaction mixture was heated at 140° C. during 30 minutes by microwave irradiation.", "The reaction mixture was further heated by microwave irradiation for 60 min at 160° C. and next the reaction mixture was concentrated.", "The residue was dissolved in EtOAc (50 mL) and water (50 mL) The organic layer was dried over magnesium sulphate, filtered and concentrated.", "The obtained residue was purified by silica gel column chromatography using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated and further purified by prep HPLC (Stationary phase: RP XBridge Prep C18 ODB—5 μm, 30×250 mm, Mobile phase: 0.25% NH4HCO3 solution in water, CH3CN) yielding compound 309 (20 mg) as a white powder after drying overnight in vacuo at 50° C. Method D: Rt: 1.91 min m/z: 479.1 (M−H)− Exact mass: 480.1.Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 180.7° C. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.16 (d, J=7.0 Hz, 3H), 3.31 (s, 3H), 3.77 (s, 3H), 3.90-4.02 (m, 1H), 4.64-4.73 (m, 2H), 7.55 (t, J=9.1 Hz, 1H), 7.96 (ddd, J=9.2, 4.9, 2.6 Hz, 1H), 8.18 (dd, J=5.7, 2.6 Hz, 1H), 8.69 (d, J=8.4 Hz, 1H), 10.54 (s, 1H).", "Compound 310: 5-cyano-N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Compound 301 (prepared similarly as described in the synthesis of 301, but on a larger scale, 185.6 mg, 0.346 mmol), copper (I) cyanide (93.04 mg, 1.04 mmol), DMF (2 mL, 25.8 mmol) was heated 110 minutes at 160° C. under microwave irradiation.", "This was diluted with EtOAc (50 mL) washed with ammonia, dried over magnesium sulphate, filtered and concentrated.", "The residue was purified by silica gel chromatography with EtOAc/heptane gradient from 10 to 50%.", "The product fractions were concentrated.", "The residue was dissolved in methanol (5 mL) and the product crystallised upon addition of water.", "The white powder was filtered off and dried overnight in vacuo at 50° C., resulting in compound 310 (45 mg).", "Method D: Rt: 1.91 min m/z: 460.3 (M−H)− Exact mass: 461.1.Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 211.4° C.′H NMR (400 MHz, DMSO-d6) δ ppm 1.24 (d, J=7.0 Hz, 3H), 3.94 (s, 3H), 4.04-4.15 (m, 1H), 7.57 (t, J=9.1 Hz, 1H), 7.93-7.99 (m, 1H), 8.17 (dd, J=5.7, 2.6 Hz, 1H), 9.32 (d, J=8.6 Hz, 1H), 10.87 (s, 1H).", "Compound 311: N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]-5-vinyl-pyrrole-2-carboxamide Nitrogen was flushed through a mixture of compound 301 (prepared similarly as described in the synthesis of 301, but on a larger scale, 446 mg, 0.87 mmol) potassium vinyltrifluoroborate (348.0 mg, 2.60 mmol), Cs2CO3 (846.5 mg, 2.60 mmol), DME (7 mL), water (1 mL) during 5 minutes.", "Tetrakis(triphenylphosphine)palladium(0) (200.1 mg, 0.17 mmol) was added and the reaction mixture was heated at 140° C. during 30 minutes by microwave irradiation.", "The reaction mixture was concentrated.", "The obtained residue was dissolved in EtOAc (50 mL) and water (25 mL).", "The organic layer was dried over magnesium sulphate, filtered and concentrated.", "The residue was subjected to silica gel column chromatography using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated and the obtained residue was dissolved in methanol (10 mL).", "Water was added until crystallisation began.", "The white powder was filtered off and dried in vacuo at 50° C., resulting in compound 311 (297 mg).", "Method D: Rt: 1.94 min m/z: 461.1 (M−H)− Exact mass: 462.1.Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 195.8° C. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.17 (d, J=6.8 Hz, 3H), 3.77 (s, 3H), 3.87-3.98 (m, 1H), 5.78-5.82 (m, 1H), 5.84 (s, 1H), 6.80-6.91 (m, 1H), 7.55 (t, J=9.1 Hz, 1H), 7.96 (ddd, J=9.2, 4.8, 2.6 Hz, 1H), 8.19 (dd, J=5.7, 2.6 Hz, 1H), 8.66 (d, J=8.8 Hz, 1H), 10.51 (s, 1H).", "Compound 312: N-(2,4-difluorophenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Et3N (0.19 mL, 1.35 mmol) was added to 3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylic acid (146 mg, 0.46 mmol), HATU (218 mg, 0.57 mmol) 2,4-difluoroaniline (119.8 mg, 0.92 mmol) in DMF (1 mL, 12.92 mmol) and stirred at 65° C. overnight.", "The solution was directly charged on a silica gel column and purified by column chromatography using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated and the residue was crystallised from methanol (10 mL) upon addition of water.", "The white crystals were filtered off and dried at 50° C. overnight, resulting in compound 312 (105 mg).", "Method D: Rt: 1.88 min m/z: 428.0 (M−H)− Exact mass: 429.1.Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 179.4° C.′H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (d, J=7.0 Hz, 3H), 3.81 (s, 3H), 3.91-4.03 (m, 1H), 7.07-7.14 (m, 1H), 7.31-7.39 (m, 1H), 7.54 (d, J=4.6 Hz, 1H), 7.63-7.72 (m, 1H), 8.59 (d, J=8.8 Hz, 1H), 9.69 (s, 1H).", "Compound 313: N-(3-chloro-5-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide To a solution of 3-chloro-2-fluoro-5-nitro-benzoic acid (9 g, 40.99 mmol) in DMF (150 mL), HATU (31.17 g, 82.0 mmol) and DIPEA (15.89 g, 123.0 mmol) were added The reaction was stirred at room temperature for 10 minutes.", "NH4Cl (3.29 g, 61.5 mmol) was added and the mixture was stirred overnight.", "Water was added and the mixture was extracted with ethyl acetate.", "The organic layer was collected, washed with brine, dried and evaporated.", "The crude was purified by column chromatography over silica gel (petrol ether/ethyl acetate=1/1) resulting in 3-chloro-2-fluoro-5-nitro-benzamide (3 g).", "To a solution of 3-chloro-2-fluoro-5-nitro-benzamide (3 g) in CH3CN (50 mL), POCl3 was added (6.86 g, 44.74 mmol) dropwise.", "The mixture was stirred at 80° C. overnight.", "The mixture was evaporated and NaHCO3 solution was added to adjust the pH to 7-8.CH2Cl2 was added and the organic layer was collected, dried and evaporated resulting in 3-chloro-2-fluoro-5-nitro-benzonitrile (1.6 g).", "A mixture of 3-chloro-2-fluoro-5-nitro-benzonitrile (1.5 g, 7.48 mmol) in ethyl acetate (40 mL) was hydrogenated at room temperature with Pd/C (0.3 g) as a catalyst.", "After uptake of H2, the catalyst was filtered off and the filtrate was evaporated.", "The crude compound was purified by high-performance liquid chromatography (Column: ADIKMA Diamonsil(2) C18, 150*25*5 um, Flow rate: 35 mL/min, Mobile Phase A: Purified water (containing 0.5% HCl), Mobile Phase B: CH3CN, Gradient: 53-83% (% B).", "NaHCO3 solution was added to adjust the pH to 8.The desired fraction was collected and the solvent was concentrated in vacuo resulting in 5-amino-3-chloro-2-fluoro-benzonitrile (253 mg).", "Compound 313 (118 mg) was prepared similarly as described for compound 312 using 5-amino-3-chloro-2-fluoro-benzonitrile instead of 2,4-difluoroaniline.", "Method D: Rt: 2.01 min m/z: 469.0 (M−H)− Exact mass: 470.0.Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 205.4° C. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.18 (d, J=7.0 Hz, 3H), 3.81 (s, 3H), 3.92-4.04 (m, 1H), 7.58 (d, J=4.4 Hz, 1H), 8.08 (dd, J=5.1, 2.6 Hz, 1H), 8.21 (dd, J=6.7, 2.5 Hz, 1H), 8.64 (d, J=8.4 Hz, 1H), 10.40 (s, 1H).", "Compound 314: 5-chloro-N-(3-cyano-2,4-difluoro-phenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide NCS (20.0 mg, 0.15 mmol) was added to compound 181 (synthesized similarly as described for compound 181, but on a larger scale, 68 mg, 0.15 mmol) acetonitrile (1 mL, 19.15 mmol) DMF (1 mL) and stirred over weekend.", "More NCS (0.75 eq) was added and the reaction mixture was stirred overnight.", "The reaction mixture was charged directly on a silica gel column and purified using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated.", "The obtained residue was dissolved in methanol (5 mL) and the product crystallised upon addition of water.", "The white powder was filtered off and dried overnight in vacuo at 50° C., resulting in compound 314 (9.6 mg).", "Method B: Rt: 1.05 min m/z: 486.9 (M−H)− Exact mass: 488.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.22 (d, J=7.0 Hz, 3H), 3.80 (s, 3H), 3.95-4.15 (m, 1H), 7.47 (td, J=9.0, 1.4 Hz, 1H), 8.03 (td, J=8.9, 6.2 Hz, 1H), 8.96 (d, J=8.8 Hz, 1H), 10.22 (s, 1H).", "Compound 315: 5-bromo-N-(3-cyano-2,4-difluoro-phenyl)-3-fluoro-1-methyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Compound 181 (synthesized similarly as described for compound 181, but on a larger scale, 221 mg, 0.486 mmol) and NBS (129.9 mg, 0.73 mmol) were dissolved in DMF (1.5 mL) and acetonitrile (1.5 mL) and stirred overnight.", "Extra NBS (50 mg) was added and the mixture was stirred for 30 minutes.", "The reaction mixture was subjected directly to column chromatography on a silica gel column chromatography system using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated.", "The residue was crystallised from methanol (10 mL) upon addition of water.", "The white crystals were filtered off and dried overnight in vacuo at 50° C., resulting in compound 315 (125 mg).", "Method D: Rt: 1.93 min m/z: 533.0 (M−H)− Exact mass: 534.0.Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 197.6° C. 1H NMR (360 MHz, DMSO-d6) δ ppm 1.22 (d, J=7.0 Hz, 3H), 3.81 (s, 3H), 3.95-4.08 (m, 1H), 7.48 (s, 1H), 7.98-8.07 (m, 1H), 8.95 (d, J=8.8 Hz, 1H), 10.28 (s, 1H).", "Compound 316: 3-cyano-N-(3-cyano-4-fluoro-phenyl)-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxamide Ethyl 3-fluoro-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (211 mg, 0.59 mmol), potassium cyanide (190.9 mg, 2.93 mmol), DMA (5 mL, 54.0 mmol), 18-crown-6 (156.6 mg, 0.59 mmol) were heated at 165° C. during 6 hours and further overnight at 150° C. The reaction mixture was concentrated.", "The obtained residue was dissolved in water/EtOAc (10/20 mL) The organic layer was dried over magnesium sulphate, filtered and concentrated.", "The obtained residue was purified by silica gel column chromatography using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated yielding ethyl 3-cyano-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (27 mg) as a clear oil which was used as such.", "Method D: Rt: 1.74 min m/z: 366.0 (M−H)− Exact mass: 367.1.Lithium bis(trimethylsilyl)amide in toluene (0.296 mL, 1 M, 0.296 mmol) was added to a mixture of ethyl 3-cyano-1,5-dimethyl-4-[[(1R)-2,2,2-trifluoro-1-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (27 mg, 0.07 mmol) and 5-amino-2-fluoro-benzonitrile (13.1 mg, 0.10 mmol) in THF (2 mL) and stirred overnight.", "The reaction mixture was quenched with NH4Cl solution (5 mL) and diluted with brine (5 mL), then extracted with EtOAc (20 mL).", "The organic layer was dried over magnesium sulphate, filtered and concentrated.", "The residue was dissolved in DMF (1 mL) and purified by silica gel column chromatography using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated and the residue dissolved in methanol (2 mL).", "Water was added until crystallisation began.", "The crystals were filtered off and dried in vacuo at 50° C., resulting in compound 316 (8 mg).", "Method D: Rt: 1.78 min m/z: 456.1 (M−H)− Exact mass: 457.1.1H NMR (360 MHz, DMSO-d6) δ ppm 1.20 (d, J=6.8 Hz, 3H), CH3 overlapping DMSO signal, 3.72 (s, 3H), 3.93-4.05 (m, 1H), 7.59 (t, J=9.1 Hz, 1H), 7.94 (ddd, J=9.1, 4.8, 2.8 Hz, 1H), 8.20 (dd, J=5.7, 2.6 Hz, 1H), 8.75 (d, J=9.0 Hz, 1H), 11.16 (s, 1H).", "Compound 317: N-(3-cyano-4-fluoro-phenyl)-4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide Ethyl 4-chlorosulfonyl-3-fluoro-1-methyl-pyrrole-2-carboxylate (725 mg, 2.54 mmol), (2R)-3,3-difluorobutan-2-amine hydrochloride (415.7 mg), NaHCO3 (853 mg, 10.2 mmol), acetonitrile (10 mL) and molecular sieves 4A (3000 mg) were heated at 80° C. for 18 hours in a pressure tube.", "The reaction mixture was filtered and the solids on filter were washed with acetonitrile (2×10 mL).", "The filtrate was concentrated.", "The residue (1 g) was subjected to silica gel column chromatography using a gradient from 0 till 100% EtOAc in heptane.", "The product fractions were concentrated in vacuo at 50° C. yielding ethyl 4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxylate (882 mg) as a white powder.", "Ethyl 4-[[(1R)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxylate (150 mg, 0.42 mmol) and 5-amino-2-fluorobenzonitrile (75.9 mg, 0.54 mmol) were dissolved in THF (5 mL).", "Lithium bis(trimethylsilyl)amide (1.67 mL, 1 M, 1.67 mmol) was added drop wise and the reaction mixture was stirred at room temperature for 30 minutes.", "The reaction mixture was quenched with sat.", "NH4Cl (aq, 5 mL).", "The organic layer was removed and the aqueous layer extracted with CH2Cl2 (2×5 mL).", "The combined organic layers were evaporated to dryness and the residue was purified by silica gel chromatography (ethyl acetate in heptane 0 to 100% and again with ethyl acetate in heptane 0 to 60%).", "The desired fractions were evaporated to dryness, the resulting residue was dissolved in refluxing isopropanol (7 mL) and sonicated to afford a suspension.", "The white solids were filtered and washed with isopropanol (1 mL) to afford compound 317 (115 mg) as off white powder.", "1H NMR (400 MHz, DMSO-d6) δ ppm 1.07 (d, J=6.8 Hz, 3H), 1.58 (t, J=19.1 Hz, 3H), 3.45-3.61 (m, 1H), 3.81 (s, 3H), 7.48-7.54 (m, 1H), 7.54 (t, J=9.2 Hz, 1H), 7.96 (ddd, J=9.2, 4.9, 2.6 Hz, 1H), 8.04-8.37 (m, 1H), 8.17 (dd, J=5.7, 2.6 Hz, 1H), 10.32 (br.", "s., 1H).", "Method B: Rt: 0.98 min m/z: 431.1 (M−H)− Exact mass: 432.1.Compound 318: N-(3-cyano-4-fluoro-phenyl)-4-[[(1S)-2,2-difluoro-1-methyl-propyl]sulfamoyl]-3-fluoro-1-methyl-pyrrole-2-carboxamide Compound 318 (111 mg) was prepared similarly as described for compound 317, using (2S)-3,3-difluorobutan-2-amine hydrochloride instead of (2R)-3,3-difluorobutan-2-amine hydrochloride.", "Method B: Rt: 0.98 min m/z: 431.1 (M−H)− Exact mass: 432.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.07 (d, J=6.8 Hz, 3H), 1.58 (t, J=19.1 Hz, 3H), 3.48-3.61 (m, 1H), 3.82 (s, 3H), 7.52 (d, J=4.6 Hz, 1H), 7.54 (t, J=9.2 Hz, 1H), 7.96 (ddd, J=9.2, 4.9, 2.9 Hz, 1H), 8.10-8.28 (m, 1H), 8.17 (dd, J=5.8, 2.8 Hz, 1H), 10.34 (br.", "s., 1H).", "Differential scanning calorimetry: From 30 to 300° C. at 10° C./min: peak at 167.9° C. Compound 319: N-(3-cyano-4-fluoro-phenyl)-3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxamide A mixture ethyl 4-chlorosulfonyl-3-fluoro-1-methyl-pyrrole-2-carboxylate (640 mg, 2.20 mmol) 1-(trifluoromethyl)cyclobutan-1-amine (1710 mg, 12.29 mmol), NaHCO3 (553 mg, 6.58 mmol), acetonitrile (12.8 mL, 245.1 mmol) and molecular sieves 4A (250 mg) was stirred and refluxed in total for 5 days (After 2 days another 4 equiv of 1-(trifluoromethyl)cyclobutan-1-amine were added).", "The reaction mixture was filtered while still hot.", "The filtrate was concentrated.", "and the obtained residue was purified by column chromatography by silica gel chromatography using a gradient from 10 to 100% EtOAc in heptane.", "The product fractions were concentrated in vacuo at 50° C. yielding ethyl 3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxylate (631 mg) as white crystals.", "Method D: Rt: 1.90 min m/z: 371.3 (M−H)− Exact mass: 372.1.A solution of ethyl 3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxylate (624 mg, 1.68 mmol), LiOH (120.4 mg, 5.03 mmol) in THF (10 mL) and water (distilled, 10 mL) was stirred overnight.", "HCl (1M in H2O) (5.03 mL, 1 M, 5.03 mmol) was added and THF distilled off.", "The white precipitate was filtered off and dried overnight in vacuo at 50° C., resulting in 3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxylic acid (412 mg) Method D: Rt: 1.04 min m/z: 343.0 (M−H)− Exact mass: 344.0.1H NMR (400 MHz, DMSO-d6) δ ppm 1.82 (quin, J=8.1 Hz, 2H), 2.26-2.35 (m, 2H), 2.39-2.48 (m, 2H), 3.82 (s, 3H), 7.53 (d, J=4.8 Hz, 1H), 8.67 (s, 1H), 13.12 (br.", "s., 1H).", "Et3N (0.23 mL, 1.62 mmol) was added to a mixture of 3-fluoro-1-methyl-4-[[1-(trifluoromethyl)cyclobutyl]sulfamoyl]pyrrole-2-carboxylic acid (186 mg, 0.54 mmol), HATU (257 mg, 0.676 mmol) and 5-amino-2-fluoro-benzonitrile (147.323 mg, 1.082 mmol) in DMF (2 mL) and the mixture was stirred 4 hours at 65° C. The reaction mixture was purified directly by silica gel column chromatography using a gradient from 10 till 100% EtOAc in heptane.", "The product fractions were concentrated in vacuo yielding a white powder which was dried overnight in vacuo at 50° C. This powder was dissolved in warm methanol (25 mL) and water was added until crystallisation began.", "The white crystals were filtered off and dried in vacuo at 50° C. overnight, resulting in compound 319 (157 mg).", "Method D: Rt: 1.96 min m/z: 461.3 (M−H)− Exact mass: 462.1.1H NMR (400 MHz, DMSO-d6) δ ppm 1.78-1.91 (m, 2H), 2.28-2.37 (m, 2H), 2.41-2.48 (m, 2H), 3.82 (s, 3H), 7.50-7.58 (m, 2H), 7.97 (ddd, J=9.2, 4.9, 2.6 Hz, 1H), 8.17 (dd, J=5.8, 2.8 Hz, 1H), 8.71 (s, 1H), 10.36 (s, 1H).", "Biological Examples—Anti-HBV Activity of Compounds of Formula (ID) The anti-HBV activity was measured using a stable transfected cell line, HepG2.2.15.This cell line was described to secrete relatively consistent high levels of HBV virion particles, which have been shown to cause both acute and chronic infection and disease in chimpanzees.", "For the antiviral, assay cells were treated twice for three days with serially diluted compound in 96-well plates in duplicate.", "After 6 days of treatment the antiviral activity was determined by quantification of purified HBV DNA from secreted virions using realtime PCR and an HBV specific primer set and probe.", "The anti HBV activity was also measured using the HepG2.117 cell line, a stable, inducibly HBV producing cell line, which replicates HBV in the absence of doxicycline (Tet-off system).", "For the antiviral assay, HBV replication was induced, followed by a treatment with serially diluted compound in 96-well plates in duplicate.", "After 3 days of treatment, the antiviral activity was determined by quantification of intracellular HBV DNA using realtime PCR and an HBV specific primer set and probe.", "Cytotoxicity of the compounds was tested using HepG2 cells, incubated for 4 days in the presence of compounds.", "The viability of the cells was assessed using a Resazurin assay.", "Results are displayed in Table 1.TABLE 1 HepG2 HepG2 HepG2 Co. 2.15 117 4 days No.", "EC50 (μM) EC50 (μM) CC50 (μM) 1 0.42 3.10 >25 2 0.03 0.06 >25 3 0.07 0.10 >25 4 0.10 0.06 >25 5 0.03 0.02 >25 6 0.02 0.02 >25 7 0.12 0.10 >25 8 0.02 0.02 >25 9 0.01 0.03 >25 10 0.11 0.08 >25 11 0.03 0.02 >25 12 0.12 0.06 >25 13 0.46 0.14 >25 13a 0.35 0.20 >25 13b 1.01 0.46 >25 14 0.04 0.02 >25 15 0.16 0.13 >25 16 0.06 0.03 >25 17 0.03 0.02 >25 18 <0.02 0.03 >25 19 0.06 0.08 >25 20 0.07 0.06 >25 21 0.22 0.84 >25 22 0.08 0.07 >25 23 0.02 0.13 >25 24 0.20 0.30 >25 25 0.34 0.23 >25 26 0.14 0.26 >25 27 0.04 0.06 >25 28 0.10 0.14 >25 29 0.15 0.21 >25 30 0.45 0.33 >25 31 0.13 0.39 >25 32 0.18 0.34 >25 33 0.03 0.04 >25 34 0.03 <0.02 >25 35 0.03 0.02 >25 36 0.08 0.04 >25 37 0.73 0.38 >25 38 0.05 0.02 >25 39 0.05 0.04 >25 40 0.20 0.12 >25 41 0.52 0.33 >25 42 0.54 0.72 >25 43 0.11 0.13 >25 44 0.37 0.26 >25 45 0.32 0.34 >25 46 0.12 0.17 >25 47 0.10 0.10 >25 48 0.05 0.06 >25 49 0.07 0.02 >25 50 0.07 0.05 >25 51 >1 >1 >25 52 0.26 0.33 >25 53 0.26 0.18 >25 54 0.20 0.25 >25 55 0.21 0.11 >25 56 0.02 <0.02 >25 57 0.06 0.05 >25 58 0.09 0.06 >25 59 0.03 0.03 >25 60 0.02 0.03 24.1 61 >1 >25 62 0.27 0.14 >25 63 0.06 0.04 >25 64 0.13 0.05 >25 65 0.01 0.01 >25 66 0.03 0.03 >25 67 0.02 0.03 >25 68 0.07 0.07 >25 69 0.03 0.07 >25 70 0.02 0.04 >25 71 0.10 0.13 >25 72 0.01 0.01 >25 73 0.10 14.1 74 0.02 0.02 >25 75 0.18 0.18 >25 76 0.18 0.13 >25 77 0.07 0.18 >25 78 0.02 0.03 >25 79 0.53 0.46 >25 80 0.04 0.09 >25 81 0.01 0.05 >25 82 0.17 0.49 >25 83 >1 1.35 >25 84 0.46 0.61 >25 85 0.03 0.05 >25 86 0.37 0.35 >25 87 0.96 >1 >25 88 0.02 0.03 >25 89 0.02 0.02 >25 90 0.05 0.03 >25 91 0.06 0.04 >25 92 0.04 0.03 >25 93 0.03 0.03 >25 94 0.009 0.01 >25 95 0.13 0.06 >25 96 0.01 0.03 23.7 97 0.03 0.03 >25 98 0.81 0.54 >25 99 0.13 0.10 >25 100 0.06 0.05 12.2 101 0.03 0.03 >25 102 0.06 0.06 >25 103 0.05 0.02 >25 104 0.02 0.02 >25 105 0.03 0.02 >25 106 0.01 0.01 >25 107 0.01 0.01 >25 108 0.01 >25 109 0.24 0.10 >25 110 0.02 0.03 >25 111 0.007 0.007 >25 112 0.06 0.09 >25 113 0.03 0.02 >25 114 0.10 0.05 >25 115 0.30 0.11 >25 116 0.03 0.02 >25 117 0.007 0.01 >25 118 0.05 0.02 >25 119 0.03 0.01 >25 120 0.03 0.03 >25 121 0.05 0.04 >25 122 0.07 >1 13.1 123 0.04 0.04 >25 124 0.04 0.04 >25 125 0.19 0.08 16.7 126 0.59 0.23 >25 127 0.05 0.19 >25 128 0.15 0.09 >25 129 0.17 0.08 >25 130 0.09 0.15 >25 131 0.01 0.01 >25 132 0.08 0.07 >25 133 0.04 0.08 >25 134 0.18 0.13 >25 135 0.02 0.26 >25 136 0.06 0.06 >25 137 0.03 0.04 16.5 138 0.10 0.03 >25 139 0.05 0.03 >25 140 0.10 0.06 >25 141 0.04 0.15 >25 142 0.15 0.42 >25 143 0.05 0.15 >25 144 0.05 0.07 >25 145 0.04 0.03 >25 146 0.07 0.04 >25 147 0.08 0.04 >25 148 0.11 0.07 >25 149 0.04 0.03 >25 150 0.09 0.06 >25 151 0.08 0.07 >25 152 0.24 0.08 >25 153 0.27 0.15 >25 154 0.13 0.08 >25 155 0.03 0.05 >25 156 0.04 0.03 >25 157 0.08 0.05 >25 158 0.12 0.36 >25 159 0.09 0.81 >25 160 0.16 0.13 >25 161 >1 0.91 >25 162 >1 0.89 >25 163 0.18 0.11 14.3 164 0.13 0.13 >25 165a 0.15 0.04 9.3 165b 0.12 0.02 4.8 166 0.14 0.12 >25 166a 0.14 0.10 17.9 166b 0.31 0.17 21.3 167 0.12 0.31 >25 168 0.12 0.32 >25 169 0.12 0.07 11.2 169a 0.14 0.05 16.1 169b 0.04 0.03 17.1 170 <0.005 0.005 >100 171 0.02 0.02 >25 172 0.10 0.08 >25 173 0.21 0.32 >25 174 0.08 0.04 >25 175 0.07 0.13 >25 176 0.50 0.37 >25 177 0.33 0.26 >25 178 0.04 0.09 >25 179 0.30 0.27 >25 180 0.01 0.02 >25 181 0.008 0.006 >25 182 0.01 0.03 >25 183 0.02 0.01 >25 184 0.008 0.006 >25 185 0.006 0.005 >25 186 0.008 0.005 >25 187 0.008 0.006 >25 188 0.04 0.03 >25 189 0.007 0.007 11.3 190 0.09 0.10 >25 191 0.18 0.16 >25 192 0.57 0.19 >25 193 0.14 0.11 >25 194 0.09 0.05 >25 195 0.04 0.04 >25 196 0.10 0.08 >25 197 0.12 0.09 >25 198 0.15 0.08 >25 199 0.006 0.008 >25 200a 0.10 0.05 >25 200b 0.09 0.10 >25 201 0.07 0.02 >25 202 0.03 0.02 >25 203 0.38 0.47 >25 204 0.65 0.62 >25 205 0.08 0.03 13.0 206 0.03 0.09 >25 207 0.05 0.14 >25 208 0.20 0.66 >25 209 0.09 0.09 >25 210 0.05 0.05 >25 211 0.04 0.04 >25 212 0.09 0.04 >25 213 0.21 0.31 >25 214 0.06 0.02 >25 215 0.02 0.010 >25 216 0.18 0.46 >25 217 0.005 0.005 >25 218 0.009 0.007 >25 219 0.01 0.009 >25 220 0.10 0.04 >25 221 0.007 0.006 >25 222 0.004 0.009 >25 223 0.12 0.09 >25 224 0.22 0.26 >25 225 0.07 0.07 >25 226 0.19 0.21 >25 227 0.02 0.04 >25 228a 0.03 0.03 >25 228b 0.03 0.03 >25 229 0.004 0.004 >25 230 0.008 0.03 >25 231 0.04 0.03 >25 232 0.02 0.02 >25 233 0.09 0.16 >25 234 0.02 0.03 >25 235 0.01 0.01 >25 236a 0.02 0.05 >25 236b 0.06 0.05 >25 237 0.08 0.10 >25 238 0.10 0.11 >25 239 0.02 0.01 >25 240 0.02 0.05 >25 241 0.01 0.01 >25 242 0.20 0.30 >25 243 0.11 0.10 >25 244 0.14 0.53 >25 245 0.04 0.04 >25 246 0.05 0.06 >25 247 0.03 0.03 >25 248 0.03 0.07 >25 249 0.07 0.18 1.7 250 0.007 0.40 20.0 251 0.01 0.06 >25 252 0.05 0.08 >25 253 0.01 0.01 >25 254 0.05 0.05 >25 255 0.09 0.10 >25 256 0.02 0.03 >25 257 0.08 0.09 >25 258 0.03 0.02 >25 259 0.05 0.05 >25 260 0.07 0.09 >25 261 0.04 0.13 >25 262 0.02 0.02 >25 263 0.005 0.008 >25 264 0.09 0.13 >25 265 0.01 0.03 >25 266 0.02 0.03 >25 267 0.006 0.009 >25 268 0.005 0.006 >25 269 0.05 0.07 >25 270 0.06 0.11 >25 271 0.009 0.02 >25 272 0.30 0.76 >25 273 0.42 0.70 >25 274 0.02 0.04 19.4 275 0.60 0.70 >25 276 0.01 0.01 >25 277 0.03 0.04 >25 278 0.006 0.01 >25 279 <0.004 0.005 >25 280 0.005 0.06 >25 281 <0.004 0.007 >25 282 <0.005 0.005 >25 283 0.02 0.03 >25 284 0.009 >25 285 0.007 >25 286 0.005 21.9 287 0.004 0.005 >25 288 0.007 0.01 >25 289 0.04 0.05 >25 290 0.02 >25 291 0.42 0.39 >25 292 0.03 15.5 293 0.02 0.05 >25 294 0.04 0.10 >25 295 0.02 0.03 >25 296 0.10 0.23 >25 297 0.04 0.09 22.6 298 0.02 0.05 23.7 299 0.009 >25 300 0.008 14.2 301 0.007 >25 302 0.03 >25 303 >12.5 >25 304 0.01 >25 305 0.17 0.35 >25 306 0.03 0.06 >25 307 0.03 >25 308 0.01 >25 309 0.53 0.32 >25 310 0.07 0.16 >25 311 0.06 >25 312 0.06 >25 313 0.02 0.05 >25 314 0.007 >25 315 0.007 >25 316 0.05 0.05 >25 317 0.006 >25 318 0.019 >25 319 <0.004 >25" ] ]
Patent_15875929
[ [ "PROCESS METHOD AND STRUCTURE FOR HIGH VOLTAGE MOSFETS", "This invention discloses a semiconductor power device disposed in a semiconductor substrate.", "The semiconductor power device comprises a plurality of trenches each having a trench endpoint with an endpoint sidewall perpendicular to a longitudinal direction of the trench and extends vertically downward from a top surface to a trench bottom surface.", "The semiconductor power device further includes a trench bottom dopant region disposed below the trench bottom surface and a sidewall dopant region disposed along the endpoint sidewall wherein the sidewall dopant region extends vertically downward along the endpoint sidewall of the trench to reach the trench bottom dopant region and pick-up the trench bottom dopant region to the top surface of the semiconductor substrate." ], [ "1.A method for manufacturing a semiconductor power device on a semiconductor substrate comprising: depositing a hard mask atop the semiconductor substrate and patterning the hard mask according to a pre-determined trench configuration; etching the semiconductor substrate through the patterned hard mask to form a plurality of trenches in the top portion of the semiconductor substrate each having a trench endpoint with an endpoint sidewall perpendicular to a longitudinal direction of the trench with the endpoint sidewall extends vertically downward from a top surface to a trench bottom surface; applying vertical high energy implant to form trench bottom dopant regions below the trench bottom surface followed by removing the hard mask; depositing an insulation layer for covering trench sidewalls and an insulation layer for covering the trench bottom surfaces; and applying a low energy tilt implant to form a sidewall dopant region along the endpoint sidewall wherein the sidewall dopant region extends vertically downward along the endpoint sidewall of the trench to reach the trench bottom dopant region to pick-up the trench bottom dopant region to the top surface of the semiconductor substrate.", "2.The method of claim 1 wherein the step of depositing the insulation for covering the trench sidewalls and the trench bottom surfaces further comprising a step of depositing the insulation layer covering the trench sidewalls and the insulation layer covering the trench bottom surfaces have approximately a same thickness.", "3.The method of claim 1 wherein: the step of depositing the insulation for covering the trench sidewalls and the trench bottom surfaces further comprising a step of depositing the insulation layer covering the trench sidewalls has a smaller layer thickness than the insulation layer covering the trench bottom surface.", "4.The method of claim 1 wherein: the step etching the semiconductor substrate through the patterned hard mask to form a plurality of trenches in the top portion of the semiconductor further comprising a step of forming each trench to extend between two pre-designated locations with the trenches have different lengths.", "5.The method of claim 1 wherein: the step etching the semiconductor substrate through the patterned hard mask to form a plurality of trenches in the top portion of the semiconductor further comprising a step of forming each trench to extend between two pre-designated locations with the trenches have different lengths and wherein the trench endpoints are distributed at the designated locations on the entire surface of the semiconductor substrate.", "6.The method of claim 1 further comprising: manufacturing the semiconductor power device as a high voltage (HV) MOSFET device 7.The method of claim 1 further comprising: manufacturing the semiconductor power device as a high voltage (HV) IGBT device" ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE PRESENT INVENTION <EOH>It is therefore an aspect of the present invention to provide a new and improved method of manufacturing for implanting the trench sidewall type dopant regions without requiring an additional implanting mask and without requiring a high energy dopant implant such that the cost of manufacturing can be reduced, whereby the above discussed limitations and difficulties can be resolved.", "Specifically, it is an aspect of this invention that the implanting process takes advantage of the special configuration of the sidewalls at the trench endpoints where the sidewall perpendicular to the longitudinal direction of the trench is inherently exposed to open space as part of the trenches.", "Therefore, a P-type dopant region implanted through this endpoint sidewall can be carried out to reach the bottom P-type dopant region formed at the bottom of the trench without requiring the application of high energy dopant ions because the dopant ions are projected only through open space of the trenches without requiring penetrating through the semiconductor substrate.", "The PCOM dopant regions linking the P-type body regions formed at the top surface of the semiconductor substrate and the trench bottom P-type dopant regions are therefore formed only at the sidewalls of the trench endpoint.", "In contrast to the conventional methods, cost savings are achieved without requiring a high energy dopant implant.", "It is another aspect of this invention that the sidewall dopant implant through the open space along the longitudinal direction of the trench onto a trench sidewall at the trench endpoint provides better control over the implanting process.", "The device performance parameters are more accurately controllable and manufacturing variations caused by uncertainties due to high energy dopant implant to penetrate through substrate are reduced.", "In a preferred embodiment, this invention discloses a semiconductor power device disposed in a semiconductor substrate.", "The semiconductor power device comprises a plurality of shielding trenches formed at the top portion of the semiconductor substrate each having a trench endpoint with an endpoint sidewall perpendicular to a longitudinal direction of the trench and extends vertically downward from a top surface to a trench bottom surface.", "The semiconductor power device further includes a trench bottom P-type dopant region disposed below the trench bottom surface and a sidewall P-type dopant region disposed along the endpoint sidewall wherein the sidewall P-type dopant region extends vertically downward along the endpoint sidewall of the trench to reach the trench bottom P-type dopant region and connect the trench bottom P-type dopant region to a P-type body region formed at the top surface of the semiconductor substrate.", "In a preferred embodiment, this invention further discloses a method for manufacturing a semiconductor power device on a semiconductor substrate.", "The method includes a step of a) applying a hard oxide mask atop a semiconductor substrate followed by patterning the hard oxide mask according to a pre-determined trench configuration; b) etching through the patterned hard mask to form a plurality of trenches at the top portion of the semiconductor substrate each having a trench endpoint with an endpoint sidewall perpendicular to a longitudinal direction of the trench with the endpoint sidewall extends vertically downward from a top surface to a trench bottom surface; c) applying a vertical (zero degrees) high energy implant to form trench bottom P-type dopant regions below the trench bottom surface followed by removing the hard mask; d) growing an oxide liner atop the silicon surface at the sidewall and bottom of the trenches; and e) applying a low energy tilt implant wherein dopant ions are implanted along a designated tilt angle to form a sidewall P-type dopant region along the endpoint sidewall, where the sidewall P-type dopant region extends vertically downward along the endpoint sidewall of the trench to reach the trench bottom P-type dopant region and connect the trench bottom P-type dopant region to a P-type body region formed at the top surface of the semiconductor substrate.", "In one of the embodiments, the dopant ions are implanted along a tilt angle approximately 45 degrees relative to the sidewall surfaces.", "These and other objects and advantages of the present invention will no doubt become obvious to those of ordinary skill in the art after having read the following detailed description of the preferred embodiment, which is illustrated in the various drawing figures." ], [ "CROSS REFERENCE TO RELATED APPLICATION Under 35 U.S.C.", "120, this application is a Divisional Application and claims the priority to U.S. patent application Ser.", "No.", "13/892,191, filed on May 10, 2013, entitled “A PROCESS METHOD AND STRUCTURE FOR HIGH VOLTAGE MOSFETS”, which is incorporated herein by reference in its entirety.", "BACKGROUND OF THE INVENTION 1.Field of the Invention The invention relates generally to the manufacturing processes and structures of semiconductor power devices.", "More particularly, this invention relates to simplified manufacturing processes and structural configurations of improved high voltage (HV) metal oxide semiconductor field effect transistors (MOSFET).", "2.Description of the Prior Art Conventional methods of manufacturing high voltage (HV) MOSFET devices are encountered with difficulties and limitations to further improve the performances due to different tradeoffs.", "In the vertical semiconductor power devices, there is a tradeoff between the drain to source resistance, i.e., on-state resistance, commonly represented by RdsA, i.e., Rds X Active Area, as a performance characteristic, and the breakdown voltage sustainable of the power device.", "Several device configurations have been explored in order to resolve the difficulties and limitations caused by these performance tradeoffs.", "Special P-composition (PCOM) structures are developed particularly to achieve these purposes.", "Specifically, the high voltage (HV) MOSFET devices implemented with the PCOM configurations include P-type dopant regions surrounding the sidewalls of the shielding trenches to link between the P-type body region formed at the top surface of the semiconductor substrate and a P-type dopant region below the shielding trenches.", "In order to form the sidewall dopant regions surrounding the trench sidewalls, the conventional methods apply an additional implanting mask with implanting openings to carry out the implantation processes on the trench sidewalls at the selected locations of the shielding trenches.", "Furthermore, in order to assure the dopant ions are implanted into the bottom portions of the trench sidewalls, implantations of dopant ions at high energy must be applied.", "The requirements of additional mask and the processes of applying high energy dopant ions cause the increase of the manufacturing costs.", "Additionally, high energy implantations into the bottom portions of the trench sidewalls followed with a diffusion process generally have less control of the formation of the dopant regions.", "These uncertainties of the manufacturing processes result in greater variations of device performance and less accurate control of the manufacturing qualities.", "FIG.", "1A is a top view of an implanting mask 100 used in the conventional process and FIGS.", "1B and 1C are two cross sectional views illustrating the configurations of a high voltage (HV) MOSFET device formed by applying conventional process along lines 1-1′ and 2-2′ of FIG.", "1A correspondingly.", "As shown in FIG.", "1A, the implanting openings 11 are located on the selected regions of the trenches 12.In order to form a MOSFET device that can sustain high power operations, a PCOM (P-composition) configuration is formed.", "In this PCOM MOSFET structure, special dopant regions are formed in part of the areas 16 below the P-type body region 13 through the implanting openings 11 to link the P-type body region and a P-type dopant region 15 below the trench 12 as shown in FIG.", "1C.", "Meanwhile, in other areas, the implantation forming the dopant regions below the body regions is blocked by the implanting mask 100.The implant mask shown in FIG.", "1A blocks the dopant implanted through the sidewalls of the trench in areas around 1-1′.", "FIG.", "1B shows a configuration where there are no dopant regions surrounding the trench sidewalls to link the body regions and the dopant regions below the trench bottom.", "The conventional manufacturing processes as shown in FIGS.", "1A to 1C requires an additional implanting mask.", "Furthermore, a high energy implant of P-type dopant, e.g., P-type dopant implant in the Mev ranges, is required to form the dopant regions below the body regions surrounding the trench sidewalls shown in FIG.", "1C.", "The manufacturing costs are increased due to the additional mask and high energy implant requirements.", "Therefore, a need still exists for the ordinary skill in the art to improve the methods of manufacturing of the power devices, particularly the devices with the PCOM configuration to resolve these technical limitations.", "It is the purpose of this invention to provide new and improved methods of manufacturing and device configurations to eliminate the requirements of additional implanting mask and high energy implantations such that the above-discussed difficulties and limitations can be overcome.", "SUMMARY OF THE PRESENT INVENTION It is therefore an aspect of the present invention to provide a new and improved method of manufacturing for implanting the trench sidewall type dopant regions without requiring an additional implanting mask and without requiring a high energy dopant implant such that the cost of manufacturing can be reduced, whereby the above discussed limitations and difficulties can be resolved.", "Specifically, it is an aspect of this invention that the implanting process takes advantage of the special configuration of the sidewalls at the trench endpoints where the sidewall perpendicular to the longitudinal direction of the trench is inherently exposed to open space as part of the trenches.", "Therefore, a P-type dopant region implanted through this endpoint sidewall can be carried out to reach the bottom P-type dopant region formed at the bottom of the trench without requiring the application of high energy dopant ions because the dopant ions are projected only through open space of the trenches without requiring penetrating through the semiconductor substrate.", "The PCOM dopant regions linking the P-type body regions formed at the top surface of the semiconductor substrate and the trench bottom P-type dopant regions are therefore formed only at the sidewalls of the trench endpoint.", "In contrast to the conventional methods, cost savings are achieved without requiring a high energy dopant implant.", "It is another aspect of this invention that the sidewall dopant implant through the open space along the longitudinal direction of the trench onto a trench sidewall at the trench endpoint provides better control over the implanting process.", "The device performance parameters are more accurately controllable and manufacturing variations caused by uncertainties due to high energy dopant implant to penetrate through substrate are reduced.", "In a preferred embodiment, this invention discloses a semiconductor power device disposed in a semiconductor substrate.", "The semiconductor power device comprises a plurality of shielding trenches formed at the top portion of the semiconductor substrate each having a trench endpoint with an endpoint sidewall perpendicular to a longitudinal direction of the trench and extends vertically downward from a top surface to a trench bottom surface.", "The semiconductor power device further includes a trench bottom P-type dopant region disposed below the trench bottom surface and a sidewall P-type dopant region disposed along the endpoint sidewall wherein the sidewall P-type dopant region extends vertically downward along the endpoint sidewall of the trench to reach the trench bottom P-type dopant region and connect the trench bottom P-type dopant region to a P-type body region formed at the top surface of the semiconductor substrate.", "In a preferred embodiment, this invention further discloses a method for manufacturing a semiconductor power device on a semiconductor substrate.", "The method includes a step of a) applying a hard oxide mask atop a semiconductor substrate followed by patterning the hard oxide mask according to a pre-determined trench configuration; b) etching through the patterned hard mask to form a plurality of trenches at the top portion of the semiconductor substrate each having a trench endpoint with an endpoint sidewall perpendicular to a longitudinal direction of the trench with the endpoint sidewall extends vertically downward from a top surface to a trench bottom surface; c) applying a vertical (zero degrees) high energy implant to form trench bottom P-type dopant regions below the trench bottom surface followed by removing the hard mask; d) growing an oxide liner atop the silicon surface at the sidewall and bottom of the trenches; and e) applying a low energy tilt implant wherein dopant ions are implanted along a designated tilt angle to form a sidewall P-type dopant region along the endpoint sidewall, where the sidewall P-type dopant region extends vertically downward along the endpoint sidewall of the trench to reach the trench bottom P-type dopant region and connect the trench bottom P-type dopant region to a P-type body region formed at the top surface of the semiconductor substrate.", "In one of the embodiments, the dopant ions are implanted along a tilt angle approximately 45 degrees relative to the sidewall surfaces.", "These and other objects and advantages of the present invention will no doubt become obvious to those of ordinary skill in the art after having read the following detailed description of the preferred embodiment, which is illustrated in the various drawing figures.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1A is a top view of an implanting mask used in conventional process and FIGS.", "1B and 1C are two side cross sectional views of the PCOMP configurations along two different locations across the trench corresponding to those shown on the implanting mask 100 of FIG.", "1A.", "FIG.", "2A is a top view of a conventional trench configuration on a semiconductor substrate.", "FIGS.", "2B, 2C-1, 2C-2, 2D-1, 2D-2, 2E-1, 2E-2 are side cross sectional views showing some steps of the process to form a PCOMP configuration at two different locations of the trench of the present invention.", "FIGS.", "2F-1 and 2F-2 are side cross sectional views showing an alternative embodiment of FIGS.", "2B-1 and 2B-2.FIGS.", "2G-1, 2G-2, 2H-1 and 2H-2 are side cross sectional views showing another alternative embodiment of FIGS.", "2E-1 and 2E-2.FIG.", "3A is a top view of an alternate configuration of trenches of various lengths on a semiconductor substrate of the present invention.", "FIG.", "3B is a top view of the semiconductor substrate after the vertical and tilt implantations to form a PCOMP configuration.", "DETAILED DESCRIPTION OF THE METHOD FIG.", "2A is a top view of a conventional trench configuration on a semiconductor substrate.", "FIGS.", "2B, 2C-1, 2C-2, 2D-1, 2D-2, 2E-1, 2E-2, 2F-1, 2F-2, 2G-1, 2G-2, 2H-1 and 2H-2 are side cross sectional views illustrating the processing steps of forming the PCOM structural configuration along the line 1-1′ and line 2-2′ in FIG.", "2A respectively in different embodiments of the present invention.", "As shown in FIG.", "2A, a plurality of trenches 120 are formed on a semiconductor substrate 101 with each trench 120 having a trench endpoint sidewall 110.The plurality of trenches 120 can be formed as follow: an oxide hard mask 111 is deposited atop the semiconductor substrate as shown in FIG.", "2B; then the hard mask 111 is patterned according to a pre-determined configuration similar as the that shown in FIG.", "2A; and the semiconductor substrate 101 is then anisotropically etched out through the patterned hard mask 111 to form the a plurality of trenches 120 with each trench 120 having trench endpoints 110 as shown in FIGS.", "2C-1 and 2C-2.A vertical high energy P-type dopant implantation (zero degrees) is first carried out, through the patterned hard mask 111, to form the P-type dopant regions 130 below the bottom surface of the trench 120 as shown in FIGS.", "2D-1 and 2D-2.The P-type dopant regions 130 function as RESURF at trench bottom for providing a maximum BV (break down voltage) blocking capability.", "As shown in FIGS.", "2E-1 and 2E-2, the hard mask 111 is removed and then a thin oxide layer 115 is deposited on the top surface of the substrate 101, on the sidewalls and the bottom surface of the trench 120 and at the endpoint sidewall 110 with a same thickness shown as t. Then a low energy tilt P-type dopant implantation, for example at 45 degrees, is carried out.", "In FIG.", "2E-1, the P-type dopant regions 140 are formed at the top surface of the substrate, below the bottom surface of the trench 120 and only at the top portions surrounding the trench sidewalls.", "In FIG.", "2E-2, the tilt implantation is also carried out at the endpoint sidewall 110 at the endpoints of the trenches 120, thus the P-type dopant regions 140 are now formed along the entire length of the trench endpoint sidewalls 110, below the bottom surface of the trench 120 and at the top surface of the substrate 101.The PCOMP structural configurations is achieved with the P-type dopant regions 140 formed along the entire length of the trench endpoint sidewalls 110 that link the P-body regions (not shown) to the bottom P-type dopant regions 130 without requiring additional implant mask and without requiring a high energy implantation.", "The manufacturing process proceeds with standard processing steps to complete the devices.", "In FIGS.", "2E-1 and 2E-2, as described above, a thin oxide layer 115 with a uniform thickness t is deposited on the top surface of the substrate 101 and on the sidewalls and the bottom surface of the trenches 120 and the endpoint sidewall 110.FIGS.", "2F-1 and 2F-2 are side cross sectional views similar to that of FIGS.", "2E-1 and 2E-2.In this embodiment, the oxide layer 125′ deposited at the top surface of the substrate 101 and at the bottom surface of the trench 120 has a thickness t2 greater than the thickness t1 of the oxide layer 125 covering the sidewalls of the trench 120 and the trench endpoint sidewall 110.The thickness t2 of the oxide layer 125′ is thick enough to block the implantation at the top surface of the substrate 101 and below the bottom surface of the trench 120.As a result, after the low energy tilt angle implantation is carried out, as shown in FIG.", "2F-1, the P-type dopant regions 140 are only formed at the top portions surrounding the sidewalls of the trenches 120.In FIG.", "2F-2, the P dopant regions 140 are only formed along the entire length of the trench endpoint sidewalls 110.As such, the PCOMP structural configurations is achieved with the dopant regions 140 formed along the entire length of the trench endpoint sidewalls 110 that links the P-type body regions formed at the top surface of the semiconductor substrate (not shown) to the bottom P-type dopant regions 130 without requiring an additional implant mask and without requiring a high energy implantation.", "The manufacturing process proceeds with standard processing steps to complete the devices.", "In an alternative embodiment, if a thin oxide layer 115 with a uniform thickness t is deposited on the top surface of the substrate 101 and on the sidewalls and the bottom surface of the trenches 120 and the endpoint sidewall 110 similar to that shown in FIGS.", "2E-1 and 2E-2, to prevent the tilted implantation punching through the oxide layer at the bottom of the trench 120, before the tilted implantation is carried out, a layer of sacrificial materials 142 is deposited at the bottom of the trench 120 in certain controlled thickness as shown in FIGS.", "2G-1 and 2G-2.The layer 142 can be high-density plasma (HDP) oxide photoresist, TEOS and the likes.", "As a result, after the low energy tilt angle implantation is carried out, as shown in FIG.", "2G-1, the P-type dopant regions 140 are only formed at the top portions surrounding the sidewalls of the trenches 120 and at the top surface of the semiconductor substrate 101, and in FIG.", "2G-2, the P dopant regions 140 are only formed along the entire length of the trench endpoint sidewalls 110 and at the top surface of the semiconductor substrate 101.The sacrificial material layer 142 is then removed as shown in FIGS.", "2H-1 and 2H-2 before the trench 120 is filled with polysilicon in a next processing step.", "The manufacturing process proceeds with standard processing steps to complete the devices.", "FIGS.", "3A-3B show an alternative embodiment of the present invention.", "As shown in FIG.", "3A, which is a top view of an alternate trench configuration on a semiconductor substrate 101 of the present invention, the length of the trenches 120′ are adjusted by providing trench endpoints at predesigned areas, for example the length of trenches 120′ is shorter than that of trenches 120 shown in FIG.", "2A, thus the density of the trench endpoint sidewalls 110′ and so as the density of the PCOMP structural configurations is adjusted, thus the PCOMP structural configurations with the P-type dopant regions formed along the entire length of the trench endpoint sidewalls that links between the P-type body regions formed at the top surface of the semiconductor substrate to the trench bottom P-type dopant regions are distributed over entire area of the semiconductor substrate.", "FIG.", "3B is a top view of the semiconductor substrate 101 after the implantation is carried out using the implantation processes described above forming PCOMP structural configurations.", "As shown in FIG.", "3B, the vertical implantation of the P-type dopant through the trench hard mask forms the P-type dopant regions 130 below the bottom surface of the trench 120′ and the tilt angle P-type dopant implantation at the trench endpoint sidewalls 110′ forms the P-type dopant regions 140 along the entire length of the trench endpoint sidewalls 110′.", "Depending on the space between two endpoints of two adjacent trenches 120′, the P-type dopant regions 140 can be merged together, as shown in FIG.", "3B, or can be separated from each other (not shown).", "Although the present invention has been described in terms of the presently preferred embodiment, it is to be understood that such disclosure is not to be interpreted as limiting.", "Various alterations and modifications will no doubt become apparent to those skilled in the art after reading the above disclosure.", "Accordingly, it is intended that the appended claims be interpreted as covering all alterations and modifications as fall within the true spirit and scope of the invention." ] ]
Patent_15875932
[ [ "SYSTEM AND METHOD OF SENDING DATA VIA ADDITIONAL SECONDARY DATA LINES ON A BUS", "A serial low-power inter-chip media bus communications link is deployed in apparatus having multiple Integrated Circuit devices.", "Communications capabilities of a device coupled to the communications link may be determined and configuration or framing message may be sent to the first device based on the capabilities.", "The messages may be transmitted on a primary data line of the communications link with a clock used to control timing of transmission on at least the primary data line.", "The communications capabilities can include information identifying a number of data wires supported by or coupled to the device.", "A first device may be configured to communicate with a second device over a secondary data line, which may be reserved for such direct communication.", "Communications on the secondary data line may be synchronized using the clock signal and may be controlled by a different protocol than the protocol used for the primary data line." ], [ "1.A communication method, comprising: determining communication capabilities of a first device coupled to a serial bus, wherein the communication capabilities identify a plurality of lines coupled to the first device including a primary data line and a secondary data line, wherein the secondary data line couples the first device to a second device; and sending a configuration message from a third device over the primary data line, wherein the configuration message includes control information configured to reserve the secondary data line for communication between the first device and the second device; and providing a clock signal that controls timing of transmissions in a plurality of time slots defined for at least the primary data line.", "2.The method of claim 1, wherein the configuration message is communicated in accordance with a first protocol and wherein the first device is configured to communicate with the second device over the secondary data line using the first protocol.", "3.The method of claim 1, wherein the configuration message is communicated in accordance with a first protocol and wherein the first device is configured to communicate with the second device over the secondary data line using a second protocol.", "4.The method of claim 1, wherein data is transmitted on the secondary data line in accordance with timing provided by the clock signal.", "5.The method of claim 1, further comprising: providing a communication channel using the primary data line and the secondary data line, wherein the first device communicates with the second device over the secondary data line using the communication channel.", "6.The method of claim 1, wherein the secondary data line connects the first device with the second device independently of the serial bus.", "7.The method of claim 1, wherein the secondary data line is one of a plurality of secondary data lines of the serial bus.", "8.The method of claim 7, wherein the control information is generated by a bus manager that communicates with a plurality of devices over the primary data line.", "9.The method of claim 1, further comprising: sending configuration messages over the primary data line to a plurality of devices; and transmitting a reconfiguration command to the plurality of devices, wherein the reconfiguration command causes each of the plurality of devices to adopt a configuration in accordance with at least one configuration message.", "10.The method of claim 9, wherein the first device is configured to relay one or more configuration messages sent over the primary data line to a fourth device.", "11.An apparatus, comprising: a communication interface configured to couple the apparatus to a first device and to a second device through a serial bus; a bus manager; and a processing circuit configured to: determine communication capabilities of a first device coupled to a serial bus, wherein the communication capabilities identify a plurality of lines coupled to the first device including a primary data line and a secondary data line, wherein the secondary data line couples the first device to a second device; and send a configuration message from a third device over the primary data line, wherein the configuration message includes control information configured to reserve the secondary data line for communication between the first device and the second device; and providing a clock signal that controls timing of transmissions in a plurality of time slots defined for at least the primary data line.", "12.The apparatus of claim 11, wherein the configuration message is communicated in accordance with a first protocol and wherein the first device is configured to communicate with the second device over the secondary data line using the first protocol.", "13.The apparatus of claim 11, wherein the configuration message is communicated in accordance with a first protocol and wherein the first device is configured to communicate with the second device over the secondary data line using a second protocol.", "14.The apparatus of claim 11, wherein data is transmitted on the secondary data line in accordance with timing provided by the clock signal.", "15.The apparatus of claim 11, wherein the processing circuit is configured to: provide a communication channel using the primary data line and the secondary data line, wherein the first device communicates with the second device over the secondary data line using the communication channel.", "16.The apparatus of claim 11, wherein the secondary data line connects the first device with the second device independently of the serial bus.", "17.The apparatus of claim 11, wherein the secondary data line is one of a plurality of secondary data lines of the serial bus.", "18.The apparatus of claim 17, wherein the control information is generated by a bus manager that communicates with a plurality of devices over the primary data line.", "19.The apparatus of claim 11, wherein the processing circuit is configured to: send configuration messages over the primary data line to a plurality of devices; and transmit a reconfiguration command to the plurality of devices, wherein the reconfiguration command causes each of the plurality of devices to adopt a configuration in accordance with at least one configuration message.", "20.The apparatus of claim 19, wherein the first device is configured to relay one or more configuration messages sent over the primary data line to a fourth device.", "21.A communication method, comprising: receiving a reconfiguration command from a primary data line of a serial bus, wherein the reconfiguration command is received from a first device coupled to the serial bus; reconfiguring a communication interface in response to a reconfiguration command; and communicating with the first device in at least one time slot defined for the primary data line while communicating with a second device over a secondary data line after reconfiguring the communication interface, wherein the secondary data line is reserved for communication with the second device.", "22.The method of claim 21, wherein data is transmitted on the primary data line in accordance with timing provided by a clock signal transmitted over a clock line of the serial bus.", "23.The method of claim 21, wherein the secondary data line is operated in accordance with a protocol used for communicating over the primary data line.", "24.The method of claim 21, wherein the secondary data line is operated in accordance with a first protocol that is different from a second protocol used for communicating over the primary data line.", "25.The method of claim 21, further comprising: reporting communication capabilities information to the first device, wherein the reconfiguration command is generated in response to the communication capabilities information.", "26.An apparatus, comprising: a processing circuit configured to: a reconfiguration command from a primary data line of a serial bus, wherein the reconfiguration command is received from a first device coupled to the serial bus; reconfigure a communication interface in response to a reconfiguration command; and communicate with the first device in at least one time slot defined for the primary data line while communicating with a second device over a secondary data line after reconfiguring the communication interface, wherein the secondary data line is reserved for communication with the second device.", "27.The apparatus of claim 26, wherein data is transmitted on the primary data line in accordance with timing provided by a clock signal transmitted over a clock line of the serial bus.", "28.The apparatus of claim 26, wherein the secondary data line is operated in accordance with a protocol used for communicating over the primary data line.", "29.The apparatus of claim 26, wherein the secondary data line is operated in accordance with a first protocol that is different from a second protocol used for communicating over the primary data line.", "30.The apparatus of claim 26, wherein the processing circuit is configured to: report communication capabilities information to the first device, wherein the reconfiguration command is generated in response to the communication capabilities information." ], [ "<SOH> BACKGROUND <EOH>Manufacturers of mobile devices, such as cellular phones, may obtain components of the mobile devices from various sources, including different manufacturers.", "For example, an application processor in a cellular phone may be obtained from a first manufacturer, while the display for the cellular phone may be obtained from a second manufacturer.", "The application processor and a display or other device may be interconnected using a standards-based or proprietary physical interface.", "In one example, the serial low-power inter-chip media bus (SLIMbus) standard is a communication bus standard that is well-suited for use in portable computing devices such as mobile phones.", "In accordance with the SLIMbus standard, components may be connected by a single SLIMbus data line and a single clock line.", "However, new generations of devices attached to a SLIMbus require ever-increasing bandwidth and throughput for applications that process and communicate audio and video data.", "Accordingly, there is a need to increase communication bandwidths available between components of mobile devices and other apparatus." ], [ "<SOH> SUMMARY <EOH>Embodiments disclosed herein provide systems, methods and apparatus that can improve the operation of SLIMbus communications links.", "The communications link may be deployed in apparatus such as a mobile terminal having multiple Integrated Circuit (IC) devices.", "In certain aspects of the disclosure, a data communications method includes determining communications capabilities of a first device coupled to a SLIMbus, sending a configuration message to the first device over a primary data line of the SLIMbus, and providing a clock signal that controls timing of transmission on at least the primary data line.", "The communications capabilities may include information identifying a number of data wires supported by or coupled to the device.", "The configuration message may cause the first device to be configured for communication with a second device over a secondary data line.", "The first device may be configured to communicate with the second device using a SLIMbus protocol.", "The first device may be configured to communicate with the second device using a non-SLIMbus protocol.", "The secondary data line may connect the first device with the second device independently of the SLIMbus.", "Communications on the secondary data line may be synchronized using the clock signal.", "The configuration message may include a framing message.", "In one aspect, the method may include allocating a plurality of communications channels in time slots on both the primary data line and the secondary data line data.", "The first device may communicate with the second device using one of the plurality of communications channels.", "In one aspect, the configuration message includes control information reserving the secondary data line for communications between the first device and the second device.", "The secondary data line may be one of a plurality of secondary data lines of the SLIMbus.", "The control information may be generated by a SLIMbus manager provided on a third device.", "The third device may be restricted to communicating over the primary data line.", "In one aspect, the method includes sending configuration messages over the primary data line to a plurality of devices, and transmitting a reconfiguration command to the one or more devices.", "The reconfiguration command may cause each of the plurality of devices to adopt a configuration in accordance with at least one configuration message.", "At least one configuration message sent over the primary data line may be addressed to a predefined set of devices.", "The first device may be configured to relay at least one configuration message sent over the primary data line to a third device.", "In certain aspects of the disclosure, an apparatus includes means for determining communications capabilities of a first device coupled to a SLIMbus, means for sending configuration and framing messages to the first device over a primary data line of the SLIMbus, and means for providing a clock signal that controls timing of transmission on at least the primary data line.", "The communications capabilities may identify a number of data wires coupled to the device.", "The first device may be configured to communicate with a second device over a secondary data line.", "In certain aspects of the disclosure, an apparatus includes a processing circuit configured to determine communications capabilities of a first device coupled to a SLIMbus, send a configuration message and/or a framing message to the first device over a primary data line of the SLIMbus, and provide a clock signal that controls timing of transmission on at least the primary data line.", "The communications capabilities may identify a number of data wires coupled to the device.", "The first device may be configured to communicate with a second device over a secondary data line.", "In certain aspects of the disclosure, a processor-readable storage medium may be encoded with one or more instructions which, when executed by at least one processing circuit, cause the at least one processing circuit to determine communications capabilities of a first device coupled to a SLIMbus, send a configuration message and/or a framing message to the first device over a primary data line of the SLIMbus, and provide a clock signal that controls timing of transmission on at least the primary data line.", "The communications capabilities may identify a number of data wires coupled to the device.", "The first device may be configured to communicate with a second device over a secondary data line.", "In certain aspects of the disclosure, a communications method includes receiving one or more configuration messages from a SLIMbus primary data line, reconfiguring a communications interface in based on the one or more configuration messages and in response to a reconfiguration command, and communicating with a first device over a first data line while communicating with a second device over a second data line.", "The second data line may be reserved for communications with the second device.", "The first data line may include the SLIMbus primary data line or a SLIMbus secondary data line.", "The second data line may be a SLIMbus secondary data line that employs a framing and control configuration used by the SLIMbus primary data line.", "The framing and control configuration may define a root clock frequency.", "The framing and control configuration may define gearing and is used to calculate a frame boundary.", "In some instances, communications on the second data line may be controlled by a non-SLIMbus protocol.", "In one aspect, the method may include reporting communications capabilities information to a manager device.", "The configuration messages may be generated in response to the communications capabilities information.", "In certain aspects of the disclosure, an apparatus includes means for receiving one or more configuration messages from a SLIMbus primary data line, means for reconfiguring a communications interface based on the one or more configuration messages and in response to a reconfiguration command, and means for communicating with a first device over a first data line while communicating with a second device over a second data line.", "The second data line may be reserved for communications with the second device.", "In certain aspects of the disclosure, an apparatus includes a processing circuit configured to receive one or more configuration messages from a SLIMbus primary data line, reconfigure a communications interface based on the one or more configuration messages and in response to a reconfiguration command, and communicate with a first device over a first data line while communicating with a second device over a second data line.", "The second data line may be reserved for communications with the second device.", "In certain aspects of the disclosure, a processor-readable storage medium stores or maintains one or more instructions.", "The instructions may be executed by at least one processing circuit and may cause the at least one processing circuit to receive one or more configuration messages from a SLIMbus primary data line, reconfigure a communications interface based on the one or more configuration messages and in response to a reconfiguration command, and communicate with a first device over a first data line while communicating with a second device over a second data line.", "The second data line may be reserved for communications with the second device." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS The present application for patent is a divisional of U.S. patent application Ser.", "No.", "14/535,992, entitled “System And Method Of Sending Data Via Additional Secondary Data Lines On A Bus” filed Nov. 7, 2014, which claims priority to now-expired Provisional Application No.", "App.", "No.", "61/904,133, entitled “System And Method Of Sending Data Via Additional Secondary Data Lines On A Bus” filed Nov. 14, 2013, which applications are assigned to the assignee hereof and hereby expressly incorporated by reference herein.", "TECHNICAL FIELD The present disclosure relates generally to data communications interfaces, and more particularly, to data communications links provided between multiple devices.", "BACKGROUND Manufacturers of mobile devices, such as cellular phones, may obtain components of the mobile devices from various sources, including different manufacturers.", "For example, an application processor in a cellular phone may be obtained from a first manufacturer, while the display for the cellular phone may be obtained from a second manufacturer.", "The application processor and a display or other device may be interconnected using a standards-based or proprietary physical interface.", "In one example, the serial low-power inter-chip media bus (SLIMbus) standard is a communication bus standard that is well-suited for use in portable computing devices such as mobile phones.", "In accordance with the SLIMbus standard, components may be connected by a single SLIMbus data line and a single clock line.", "However, new generations of devices attached to a SLIMbus require ever-increasing bandwidth and throughput for applications that process and communicate audio and video data.", "Accordingly, there is a need to increase communication bandwidths available between components of mobile devices and other apparatus.", "SUMMARY Embodiments disclosed herein provide systems, methods and apparatus that can improve the operation of SLIMbus communications links.", "The communications link may be deployed in apparatus such as a mobile terminal having multiple Integrated Circuit (IC) devices.", "In certain aspects of the disclosure, a data communications method includes determining communications capabilities of a first device coupled to a SLIMbus, sending a configuration message to the first device over a primary data line of the SLIMbus, and providing a clock signal that controls timing of transmission on at least the primary data line.", "The communications capabilities may include information identifying a number of data wires supported by or coupled to the device.", "The configuration message may cause the first device to be configured for communication with a second device over a secondary data line.", "The first device may be configured to communicate with the second device using a SLIMbus protocol.", "The first device may be configured to communicate with the second device using a non-SLIMbus protocol.", "The secondary data line may connect the first device with the second device independently of the SLIMbus.", "Communications on the secondary data line may be synchronized using the clock signal.", "The configuration message may include a framing message.", "In one aspect, the method may include allocating a plurality of communications channels in time slots on both the primary data line and the secondary data line data.", "The first device may communicate with the second device using one of the plurality of communications channels.", "In one aspect, the configuration message includes control information reserving the secondary data line for communications between the first device and the second device.", "The secondary data line may be one of a plurality of secondary data lines of the SLIMbus.", "The control information may be generated by a SLIMbus manager provided on a third device.", "The third device may be restricted to communicating over the primary data line.", "In one aspect, the method includes sending configuration messages over the primary data line to a plurality of devices, and transmitting a reconfiguration command to the one or more devices.", "The reconfiguration command may cause each of the plurality of devices to adopt a configuration in accordance with at least one configuration message.", "At least one configuration message sent over the primary data line may be addressed to a predefined set of devices.", "The first device may be configured to relay at least one configuration message sent over the primary data line to a third device.", "In certain aspects of the disclosure, an apparatus includes means for determining communications capabilities of a first device coupled to a SLIMbus, means for sending configuration and framing messages to the first device over a primary data line of the SLIMbus, and means for providing a clock signal that controls timing of transmission on at least the primary data line.", "The communications capabilities may identify a number of data wires coupled to the device.", "The first device may be configured to communicate with a second device over a secondary data line.", "In certain aspects of the disclosure, an apparatus includes a processing circuit configured to determine communications capabilities of a first device coupled to a SLIMbus, send a configuration message and/or a framing message to the first device over a primary data line of the SLIMbus, and provide a clock signal that controls timing of transmission on at least the primary data line.", "The communications capabilities may identify a number of data wires coupled to the device.", "The first device may be configured to communicate with a second device over a secondary data line.", "In certain aspects of the disclosure, a processor-readable storage medium may be encoded with one or more instructions which, when executed by at least one processing circuit, cause the at least one processing circuit to determine communications capabilities of a first device coupled to a SLIMbus, send a configuration message and/or a framing message to the first device over a primary data line of the SLIMbus, and provide a clock signal that controls timing of transmission on at least the primary data line.", "The communications capabilities may identify a number of data wires coupled to the device.", "The first device may be configured to communicate with a second device over a secondary data line.", "In certain aspects of the disclosure, a communications method includes receiving one or more configuration messages from a SLIMbus primary data line, reconfiguring a communications interface in based on the one or more configuration messages and in response to a reconfiguration command, and communicating with a first device over a first data line while communicating with a second device over a second data line.", "The second data line may be reserved for communications with the second device.", "The first data line may include the SLIMbus primary data line or a SLIMbus secondary data line.", "The second data line may be a SLIMbus secondary data line that employs a framing and control configuration used by the SLIMbus primary data line.", "The framing and control configuration may define a root clock frequency.", "The framing and control configuration may define gearing and is used to calculate a frame boundary.", "In some instances, communications on the second data line may be controlled by a non-SLIMbus protocol.", "In one aspect, the method may include reporting communications capabilities information to a manager device.", "The configuration messages may be generated in response to the communications capabilities information.", "In certain aspects of the disclosure, an apparatus includes means for receiving one or more configuration messages from a SLIMbus primary data line, means for reconfiguring a communications interface based on the one or more configuration messages and in response to a reconfiguration command, and means for communicating with a first device over a first data line while communicating with a second device over a second data line.", "The second data line may be reserved for communications with the second device.", "In certain aspects of the disclosure, an apparatus includes a processing circuit configured to receive one or more configuration messages from a SLIMbus primary data line, reconfigure a communications interface based on the one or more configuration messages and in response to a reconfiguration command, and communicate with a first device over a first data line while communicating with a second device over a second data line.", "The second data line may be reserved for communications with the second device.", "In certain aspects of the disclosure, a processor-readable storage medium stores or maintains one or more instructions.", "The instructions may be executed by at least one processing circuit and may cause the at least one processing circuit to receive one or more configuration messages from a SLIMbus primary data line, reconfigure a communications interface based on the one or more configuration messages and in response to a reconfiguration command, and communicate with a first device over a first data line while communicating with a second device over a second data line.", "The second data line may be reserved for communications with the second device.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 depicts an apparatus employing a data link between IC devices that selectively operates according to one of a plurality of available standards.", "FIG.", "2 illustrates a simplified system architecture for an apparatus employing a data link between IC devices.", "FIG.", "3 illustrates a SLIMbus communications link provided between SLIMbus components.", "FIG.", "4 illustrates a device adapted to communicate over a SLIMbus communications link.", "FIG.", "5 illustrates a first network of devices connected by a SLIMbus communications link.", "FIG.", "6 illustrates scheduling on a SLIMbus communications link.", "FIG.", "7 illustrates a second network of devices connected by a SLIMbus communications link that has multiple data lines and a manager.", "FIG.", "8 illustrates a third network of devices connected by a SLIMbus communications link that has multiple data lines.", "FIG.", "9 illustrates a fourth network of devices connected by a configurable SLIMbus communications link that has multiple data lines including shared and private data lines.", "FIG.", "10 is a block diagram illustrating an example of an apparatus employing a processing system that may be adapted according to certain aspects disclosed herein.", "FIG.", "11 is a first flow chart illustrating a method for data communications on a SLIMbus according to certain aspects disclosed herein.", "FIG.", "12 illustrates an example of an apparatus that can connect to a configurable SLIMbus communications link and perform the method of FIG.", "11 in accordance with certain aspects disclosed herein.", "FIG.", "13 is a second flow chart illustrating a method for data communications on a SLIMbus according to certain aspects disclosed herein.", "FIG.", "14 illustrates an example of an apparatus that can connect to a configurable SLIMbus communications link and perform the method of FIG.", "13 in accordance with certain aspects disclosed herein.", "DETAILED DESCRIPTION Various aspects are now described with reference to the drawings.", "In the following description, for purposes of explanation, numerous specific details are set forth in order to provide a thorough understanding of one or more aspects.", "It may be evident, however, that such aspect(s) may be practiced without these specific details.", "As used in this application, the terms “component,” “module,” “system” and the like are intended to include a computer-related entity, such as, but not limited to hardware, firmware, a combination of hardware and software, software, or software in execution.", "For example, a component may be, but is not limited to being, a process running on a processor, a processor, an object, an executable, a thread of execution, a program and/or a computer.", "By way of illustration, both an application running on a computing device and the computing device can be a component.", "One or more components can reside within a process and/or thread of execution and a component may be localized on one computer and/or distributed between two or more computers.", "In addition, these components can execute from various computer readable media having various data structures stored thereon.", "The components may communicate by way of local and/or remote processes such as in accordance with a signal having one or more data packets, such as data from one component interacting with another component in a local system, distributed system, and/or across a network such as the Internet with other systems by way of the signal.", "Moreover, the term “or” is intended to mean an inclusive “or” rather than an exclusive “or.” That is, unless specified otherwise, or clear from the context, the phrase “X employs A or B” is intended to mean any of the natural inclusive permutations.", "That is, the phrase “X employs A or B” is satisfied by any of the following instances: X employs A; X employs B; or X employs both A and B.", "In addition, the articles “a” and “an” as used in this application and the appended claims should generally be construed to mean “one or more” unless specified otherwise or clear from the context to be directed to a singular form.", "Certain aspects of the invention may be applicable to communications links deployed between electronic devices that may include subcomponents of an apparatus such as a telephone, a mobile computing device, a wearable computing device, a media player, a gaming device, an appliance, automobile electronics, avionics systems, etc.", "FIG.", "1 illustrates one example of a wireless communications device 100 that may employ a communications link between IC devices.", "In one example, the wireless communications device 100 may include a wireless communication device that communicates through an RF interface with a radio access network, a core access network, the Internet and/or another network.", "The wireless communications device 100 may include a communications transceiver 106 operably coupled to a processing circuit 102.The processing circuit 102 may include one or more IC devices, such as an application-specific IC (ASIC) 108.The ASIC 108 may include one or more processing devices, logic circuits, and so on.", "The processing circuit 102 may include and/or be coupled to processor readable storage such as a memory 112 that may maintain instructions and data that may be executed by processing circuit 102.The processing circuit 102 may be controlled by one or more of an operating system and an application programming interface (API) layer 110 that supports and enables execution of software modules residing in storage media, such as the memory 112 of the wireless device.", "The memory 112 may include read-only memory (ROM) or random-access memory (RAM), electrically erasable programmable ROM (EEPROM), flash cards, or any memory device that can be used in processing systems and computing platforms.", "The processing circuit 102 may include or have access to a local database 114 that can maintain operational parameters and other information used to configure and operate the wireless communications device 100.The local database 114 may be implemented using one or more of a database module, flash memory, magnetic media, EEPROM, optical media, tape, soft or hard disk, or the like.", "The processing circuit 102 may also be operably coupled to internal and/or external devices, which may include an antenna 122, a display system 124, and operator controls such as buttons 128, 130 and/or a keypad 126, among other components.", "In some examples, the display system 124 may include a touchscreen component.", "FIG.", "2 is a block schematic diagram 200 illustrating certain aspects of an apparatus such as the wireless communications device 100 of FIG.", "1, a wireless mobile computing device, a mobile telephone, a wireless telephone, a notebook computer, a tablet computing device, a media player, a gaming device, a wearable computing device, an appliance, or the like.", "The apparatus 200 may include a plurality of IC devices 202 and 230 that exchange data and control information through a communications link 220.The communications link 220 may be used to connect two or more IC devices 202 and 230 that are located in close proximity to one another, or that are physically located in different parts of the apparatus 200.In one example, the communications link 220 may be provided on a chip carrier, substrate or circuit board that carries the IC devices 202 and 230.In another example, a first IC device 202 may be located in a keypad section of a smartphone or flip-phone while a second IC device 230 may be located in a display section of the flip-phone, on a touchscreen display panel, etc.", "In another example, a portion of the communications link 220 may include a cable or optical connection.", "The communications link 220 may have multiple individual data links 222, 224 and 226.One communications link 226 may include bidirectional connectors, and may operate in time division, half-duplex, full-duplex, or other modes.", "One or more communications links 222 and 224 may include unidirectional connectors.", "The communications link 220 may be asymmetrically configured, providing higher bandwidth in one direction and/or between different IC devices 202, 230.In one example, a first communications link 222 between the two IC devices 202, 230 may be referred to as a forward link 222 while a second communications link 224 between the two IC devices 202, 230 may be referred to as a reverse link 224.In another example, a first IC device 202 may operate or be designated as a host, manager, master and/or transmitter, while one or more other IC devices 230 may be designated as a client, slave and/or receiver, even if both IC devices 202 and 230 are configured to transmit and receive on the communications link 222.In one example, a data link 222 may operate at a higher data rate when communicating data from a first IC device 202 to a second IC device 230 than a data link provided between the first IC device 202 and a third IC device (not shown).", "The IC devices 202 and 230 may each include a general-purpose processor or other processing and/or computing circuit or device 206, 236 adapted to cooperate with various circuits and modules in order to perform certain functions disclosed herein.", "The IC devices 202, 230 may perform different functions and/or support different operational aspects of the apparatus 200.A plurality of IC devices, including the IC devices 202 and 230 may include modems, transceivers, display controllers, user interface devices, Bluetooth interface devices, audio/visual systems, digital-to-analog converters, analog-to-digital converters, memory devices, processing devices, and so on.", "In one example, the first IC device 202 may perform core functions of the apparatus 200, including maintaining wireless communications through a wireless transceiver 204 and an antenna 214, while the second IC device 230 may support a user interface that manages or operates a display controller 232, and/or may control operations of a camera or video input device using a camera controller 234.Other features supported by one or more of the IC devices 202 and 230 may include a keyboard, a voice-recognition component, application processors, and various input or output devices.", "The display controller 232 may have circuits and software drivers that support displays such as a liquid crystal display (LCD) panel, touch-screen display, indicators and so on.", "The storage media 208 and 238 may include transitory and/or non-transitory storage devices adapted to maintain instructions and data used by the respective processors 206 and 236, and/or other components of the IC devices 202 and 230.Communication between each processor 206, 236 and its corresponding storage media 208 and 238 and other modules and circuits may be facilitated by one or more bus 212 and 242, respectively.", "Different links 222, 224 and or 226 may be capable of transmitting at comparable speeds or at different speeds, where speed may be expressed as data transfer rate and/or clocking rates.", "Data rates may be substantially the same or differ by orders of magnitude, depending on the application.", "In some applications, a single bidirectional link 226 may support communications between the first IC device 202 and the second IC device 230.The forward link 222 and/or reverse link 224 may be configurable to operate in a bidirectional mode and the forward and reverse links 222 and 224 may share the same physical connections, connectors and/or wires.", "In one example, the communication link 220 may be operated to communicate control, command and other information between the first IC device 202 and the second IC device 230 in accordance with an industry or other standard.", "Industry standards may be application specific.", "In one example, the Mobile Industry Processor Interface (MIPI) standard defines physical layer interfaces, including the SLIMbus interface, that may be used to provide an interface between an application processor IC device 202 and an IC device 230 that supports functional elements and modules of a mobile device, including a camera, display, media player, etc.", "FIG.", "3 is a simplified block diagram of a system 300 that illustrates a SLIMbus communications link 310 provided between SLIMbus components 304 and 306.The SLIMbus communications link 310 may include a plurality of SLIMbus data lines 312, 314 deployed between the SLIMbus components 304, 306.As further described herein, the SLIMbus communications link 310 may be adapted or configured to provide more than two data lines as desired or as needed to obtain a desired bandwidth and throughput on the SLIMbus communication bus 310.The SLIMbus communications link 310 may include a SLIMbus clock line 316 that has a frequency selected by dividing a “root clock” frequency.", "In some example, the root clock may have a frequency of 28 MHz or more.", "In some examples, the frequency of the SLIMbus clock line 316 may be selected by using one of 10 available clock gears.", "Clock gears may divide the clock frequency by powers of 2.In one example, the SLIMbus clock line 316 may have a frequency (fCLK) calculated using the equation: f CLK = f ROOT 2 G - 10 where fROOT is the frequency of the root clock and G is the gear selected.", "In this configuration, the maximum clock frequency is selected when G=10 and the maximum clock frequency is equal to the frequency of the root clock.", "The system 300 may include a host 302 coupled to a first SLIMbus component 304.The first SLIMbus component 304 may be coupled to a second SLIMbus component 306 using the SLIMbus communications link 310, which may include one or more of a first SLIMbus data line 312 and a second SLIMbus data line 314.The second SLIMbus component 306 may be coupled to a third component 308, which may include a SLIMbus component or a non-SLIMbus device.", "The host 302 may include a processing circuit that has one or more of a digital signal processor (DSP), a central processing unit (CPU), a graphics processing unit (GPU), a microprocessor, or any combination thereof.", "The host 302 may include a mobile station modem (MSM), a mobile data modem (MDM), a radio frequency transceiver (RTR), an application processor (APQ), or any combination thereof.", "The first SLIMbus data line 312 may support a first bandwidth and the second SLIMbus data line 314 may support a second bandwidth.", "In one example, the first SLIMbus data line 312 and the second SLIMbus data line 314 may be clocked at the same frequency, and the first SLIMbus data line 312 and the second SLIMbus data line 314 may carry data at the same data rate.", "In another example, the first SLIMbus data line 312 may have a greater bandwidth than the second SLIMbus data line 314.In another example, the second SLIMbus data line 314 may have a greater bandwidth than the first SLIMbus data line 312, when the second SLIMbus data line 314 and the first SLIMbus data line 312 are clocked at different rates.", "In the latter example, the first bandwidth may be 28 megabits per second (Mbps) and the second bandwidth may be greater than 28 Mbps.", "Throughput on one or more of the first SLIMbus data line 312 and the second SLIMbus data line 314 may be decreased when the first SLIMbus data line 312 and/or the second SLIMbus data line 314 carries control information.", "Each of the plurality of SLIMbus data lines 312, 314 may be a bi-directional data line.", "In some examples, one SLIMbus data line 312 or 314 may be a bi-directional data line while the second SLIMbus data line 314 or 312 may be a unidirectional data line.", "As used herein, a bi-directional data line may be a data line that is capable of sending data in different directions between two or more devices.", "Further, each of the plurality of SLIMbus data lines 312, 314 may be utilized to transmit data associated with a different power level.", "For example, the first SLIMbus data line 312 may be utilized for low power traffic while the second SLIMbus data line 314 may be utilized for higher power traffic.", "A power budget may be in effect for certain types of traffic.", "Power consumption may be managed or controlled in certain applications by configuring one or more of a transmit clock frequency, an encoding scheme used to encode data for transmission on the SLIMbus data line 312 or 314, data compression ratios, type of data encoded, and so on.", "During operation, data may be sent from the first SLIMbus component 304 to the second SLIMbus component 306.As used herein, data may include audio data, non-audio data, pulse-code modulation (PCM) audio data, Sony Philips Digital Interface (SPDIF) data, High Definition Audio (HDA) data, professional audio data (i.e., 192 kHz, 24 bit as used in Dolby Surround 5.1/7.1, and certain Roland Music systems), or any combination thereof.", "The first SLIMbus component 304 may send data on one or more SLIMbus data lines selected from the plurality of SLIMbus data lines 312, 314.For example, the data may be sent via the first SLIMbus data line 312, the second SLIMbus data line 314, or any combination thereof.", "In accordance with certain aspects disclosed herein, the first SLIMbus component 304 may send data in parallel over multiple SLIMbus data lines 312 and 314 or send the data serially over a single SLIMbus data line 312 or 314.Whether the data is sent in parallel or serially may depend on factors such as a size of the data, a clock frequency of at least one SLIMbus data line, a compatibility of the data with the SLIMbus data transmission protocol, a priority of the data, a quality of service requirement, or based on any combination of these and/or other factors.", "The first SLIMbus component 304 may send data in parallel using the first SLIMbus data line 312 and the second SLIMbus data line 314.In one example, the data may be divided into two portions, and the portions may be transmitted concurrently, or substantially concurrently, over the SLIMbus data lines 312 and 314.Upon receipt, the data may be interleaved and/or concatenated.", "In another example, the data may be divided into two portions and the first SLIMbus component 304 may send the data serially over one of the first SLIMbus data line 312 and the second SLIMbus data line 314.In some instances, the two portions of data may be transmitted sequentially over either the first SLIMbus data line 312 or the second SLIMbus data line 314.The data may be sent in accordance with a SLIMbus data transmission protocol, a time-division transmission protocol, or a non time-division transmission protocol.", "According to certain aspects disclosed herein, the third device 308 may be configured to be compatible with a configuration that supports the plurality of SLIMbus data lines 312, 314, as described herein.", "For example, the third device 308 may be configured to receive data from the first component 304 over the plurality of SLIMbus data lines 312, 314.Certain data sent to the third device 308 may be transmitted in accordance with a non-SLIMbus protocol, which may be a non-time division protocol or a time-division protocol other than the SLIMbus data transmission protocol.", "According to certain aspects disclosed herein, data transmitted over each SLIMbus data line 312, 314 may correspond to different SLIMbus components.", "For example, the first and second components 304, 306 may be configured to receive and transmit data using the first SLIMbus data line 312 and the SLIMbus clock line 316, while third and fourth SLIMbus components may be configured to receive and transmit data using the second SLIMbus data line 314 and the SLIMbus clock line 316.The same SLIMbus clock line 316 may control timing and rates of data transfer between different components or sets of components that each use a different SLIMbus data line 312, 314.A SLIMbus device may be restricted or configured for connection to a single SLIMbus data line 312, 314.In some examples, one or more SLIMbus components 304, 306 may be connected to a plurality of available SLIMbus data lines 312, 314, and may be connected to a single SLIMbus clock line 316.In addition, devices configured for compatibility with multiple SLIMbus data lines may coexist in the system 300 with legacy devices that support only one SLIMbus data line.", "FIG.", "4 illustrates an apparatus 400 adapted to communicate over a SLIMbus communications link 310.In the example, the apparatus 400 includes an IC device 402 that can be adapted to communicate with one or more other IC devices (not shown) using a plurality of SLIMbus data lines 312, 314 and the SLIMbus clock line 316.The IC device 402 may correspond to a functional component implemented using one or more modules or circuits, such as a processing circuit or device, a coder/decoder (CODEC), an input device, an output device, etc.", "The IC device 402 may include a SLIMbus component 304 or 306 illustrated in FIG.", "3, in addition to system level device logic 404.In one example, the IC device 402 operates as a SLIMbus component 304 and the host 302 of FIG.", "3 includes the system level device logic 404.In one example, the IC device 402 may include a direct memory access (DMA) layer 408, a SLIMbus device layer 410, a transport protocol layer 412, a frame layer 414, and a physical layer 416.The DMA layer 408 may include or be implemented by a processing circuit such as a first finite state machine (FSM) 418, a sequencer or other processing circuit or device.", "The DMA layer 408 may include a plurality of pipes, including a first pipe 420a and a second pipe 420b.", "The plurality of pipes may include additional pipes up to an nth pipe 420n.", "The plurality of pipes may be configured as one or more message channels that transmit messages such as data messages and/or user-defined configuration messages.", "The SLIMbus device layer 410 may be a generic device layer, an interface device layer, a framer device layer, a manager device layer, or any combination thereof.", "The SLIMbus device layer 410 may include a processing circuit such as a second FSM 422, one or more First-In-First-Out (FIFO) buffers and one or more ports, which may also be referred to as message ports.", "In one example, a first FIFO buffer 424a, a second FIFO buffer 424b, and other FIFO buffers up to an nth FIFO buffer 424n, a first port (Port-0) 426a, a second port (Port-1) 426b, up to an nth port (Port-n) 426n.", "Each port 426a-426n may be connected to a corresponding FIFO buffer 424a-424n.", "For example, the first port 426a may be connected to the first FIFO buffer 424a, the second port 426b may be connected to the second FIFO buffer 424b and so on, until the nth port 426n which may be connected to the nth FIFO buffer 424n.", "In some examples, each port 426a-426n may be coupled to two FIFO buffers 424a-424n, which may enable and/or support bi-directional data transfer capabilities of each individual port 424a-424n.", "For example, the first port 426a may be connected to the first FIFO buffer 424a and the second FIFO buffer 424b.", "In addition, the ports may support asynchronous connections thereby making more ports available to the apparatus 400.It will be appreciated that the use of dual-FIFO ports may effectively double an overall number of available ports in a system, because a single pair of ports may be used for bi-directional communication between two devices instead of using a dedicated pair of uplink ports and a dedicated pair of downlink ports.", "The frame layer 414 may generate a switch select signal 432 and may include a first multiplexer 434 and a second multiplexer 436.The first multiplexer 434 may be associated with data transmission 428 and the second multiplexer 436 may be associated with data reception 430.The switch select signal 432 may cause the first multiplexer 434 to transmit data via the first SLIMbus data line 312, the second SLIMbus data line 314, or any combination thereof.", "Alternatively or additionally, the switch select signal 432 may cause the second multiplexer 436 to receive data via the first SLIMbus data line 312, the second SLIMbus data line 314, or any combination thereof.", "In some configurations, the frame layer 414 may include a single multiplexer 434 or 436.For example, the IC device 402 may include two frame layers 414, each including a single multiplexer 434, 436.In another example, the transport protocol layer 412 may include the first multiplexer 434 and the second multiplexer 436, and an additional SLIMbus clock line may be used.", "However, because the additional SLIMbus clock line may consume more power than a SLIMbus data line, implementations involving multiple SLIMbus clock lines may be avoided to reduce power consumption.", "In one example, a SLIMbus clock line 316 may account for 60-70% of total power consumption attributable to the SLIMbus connection 310.FIG.", "5 is a block diagram illustrating one example of an apparatus 500 that employs a SLIMbus communications link 552 with multiple data lines 556, 558.In this example, the apparatus 500 may include devices 502, 504 and 506 that have dual data line capable SLIMbus components, and at least one device 508 that includes one or more single data line capable SLIMbus components.", "Each of the devices 502, 504, 506 and 508 may be provided in, or include an IC device.", "Each of the devices 502, 504, 506 and 508 may cooperate with one or more other IC devices or other circuits that may be disposed upon a chip carrier, within a single package, or on a circuit board, for example.", "In one example, the first device 502 (Device A) may function as an application processor that includes a master or manager 550, a first port (Port-0) 512, a second port (Port-1) 514, and a third port (Port-2) 516.The first device 502 may also include a framer 518 and a configuration register 510 that maintains configuration parameters and other information related to the operation of the first device 502.The framer 518 may correspond to, and/or implement certain functions of the frame layer 414 of FIG.", "4, for example.", "The second device 504 (Device B) may be an audio CODEC and may include a first port 522, a second port 524, a third port 526, a framer 528 and a configuration register 520.The third device 506 (Device C) may be a data modem that includes a first port 532, a second port 534, a framer 538 and a configuration register 530.The fourth device 508 (Legacy Device D) may be a legacy device, such as an input or output device (including, for example, a device related to a speaker or a microphone) that is manufactured without multiple data line SLIMbus capabilities.", "The fourth device 508 may include a first port 542, a second port 544, a framer 548 and a configuration register 540.In operation, the manager 550 may configure communications within the apparatus 500 based on a determination of the capabilities of the SLIMbus components of each of the devices 502, 504, 506 and 508.The configuration typically takes account of the data line capabilities (single, double, multiple) of the constituent devices 502, 504, 506 and 508.The manager 550 may be implemented as some combination of hardware and software.", "In one example, the manager 550 may be implemented in Device A 502, and may include or employ a processing circuit, a sequencer, a state machine, software and firmware, or any combination thereof.", "The manager 550 may determine the configuration of SLIMbus components during an enumeration process.", "For example, during enumeration, the manager 550 may determine that the first device 502, the second device 504, and the third device 506 have dual data line capable SLIMbus components and that the fourth device 508 has a single data line capable SLIMbus component.", "The manager 500 may determine the capabilities of each SLIMbus component by querying one or more of the configuration registers 510, 520, 530, 540, which maintain information identifying the capabilities of corresponding SLIMbus components or devices 502, 504, 506 and/or 508.In one example, information related to SLIMbus component capabilities may be predefined by a device manufacturer.", "In another example, the information related to SLIMbus component capabilities may be configured by a system integrator.", "In some instances, the capabilities of each SLIMbus component may be determined based on communication with a high-level operating system (HLOS).", "For example, an HLOS associated with a particular device 502, 504, 506 and/or 508 may provide a configuration file, and may exchange capability bits for each device.", "The HLOS may use a look-up table and/or query a configuration database for capability information.", "In some examples, the capabilities of each SLIMbus component may be determined through dedicated messaging, including information transmitted through a dedicated message channel.", "In one example, the dedicated message channel is provided using one or more time slots on a primary data line 556, which may be connected to all SLIMbus devices 502, 504, 506, 506.In some examples, one or more user-defined messages may be transmitted between SLIMbus components, where the user-defined messages include data indicating whether the SLIMbus components are configurable or configured for single data line, dual data line, or capable of supporting another number of SLIMbus data lines.", "FIG.", "6 includes scheduling diagrams 600, 620 that illustrate timing of transmissions associated with a SLIMbus communications link in accordance with certain aspects disclosed herein.", "The scheduling diagrams 600 and 620 illustrate different examples of scheduling applicable to the apparatus 500 of FIG.", "5.The first scheduling diagram 600 relates to an example of scheduling when a common messaging and framing is used for a plurality of SLIMbus data lines 556 and 558, while the second scheduling diagram 620 relates to an example of scheduling when each of a plurality of SLIMbus data lines 556 and 558 uses individualized messaging and framing configurations.", "The first scheduling diagram 600 relates to an example in which data may be communicated from a first SLIMbus component 502, 504, 506 and/or 508 to one or more ports of a second SLIMbus component 502, 504, 506 and/or 508 using time-division multiplexing (TDM).", "In a TDM scheme, a sequence of primary data frames 602 may be transmitted on a primary data line 556.A plurality of sequential time intervals (slots) may be defined by the TDM scheme.", "In one example, a slot may be defined as four contiguous bits.", "Bandwidth allocation for various data organizations, from 4-bit data to 32-bit data (or more) can be accomplished by grouping the 4-bit Slots.", "The duration, function and frequency of occurrence of each slot may be configured according to application needs and operational considerations.", "A frame may be defined as including 192 contiguous slots.", "Each primary data frame 602 typically includes framing slots 604 and 608 that precede one or more data slots 608a-608d and 610a-610d, respectively.", "In one example, the first slot of each frame may be defined as a control slot, which may carry a 4-bit frame sync symbol and other slots may carry framing information.", "A superframe may be defined as a transmission that includes 8 contiguous frames.", "The timing of a superframe may be defined by the timing of slots in the constituent frames that make up the superframe, and the superframe transmission rate may be dynamically configured through selection of a combination of the root frequency and gearing.", "The data slots 608 and 610 may be used to carry the payload data of one or more messages.", "The data slots 608 and 610 may be allocated to one or more channels, where each channel carries data between a source SLIMbus component 502, 504, 506 and/or 508 and a destination SLIMbus component 502, 504, 506 and/or 508.For example, a first data slot 608a and 610a may be allocated to a first channel for communications between a first port 512 of the first device (Device A) 502 and a second port 534 of the third device (Device C) 506, data slots 608c and 610c may be allocated to carry a second channel for communications between a first port 522 of the second device (Device B) 504 and a second port 544 of the fourth device (Device D) 508.The remaining slots 608b/610b and 608d/610d may be allocated for other channels, and/or may be placed in an idle state.", "A sequence of secondary data frames 612 may be concurrently or contemporaneously transmitted on the secondary SLIMbus data line 558.The secondary data frames 612 may be apportioned into data slots 614, 616a-616c, 618a-618c and 620 corresponding in time to data slots of the primary data frames 602.In the first example 600, the first data slots 614 and 620 in the secondary data frames 612 may be idled or otherwise unused and the framing information received in data slots 604 and 606 of the primary data frames 602 may be used to configure the secondary data frames 612.In this configuration, additional bandwidth may be defined for channels defined on the primary data frames 602, and/or additional channels may be defined on the secondary data frames 612.In one example, data transmitted in the first channel may use one or more data slots 616a-616c of the secondary data frames 612 in addition to the data slots 608a and 610a allocated in the primary data frames 602.In another example, data transmitted from the second port 514 of Device A 502 to the second port 524 of Device B 504 may be sent in a third channel that is allocated one or more data slots 616b and 618b of the secondary data frames 612.Data may be transmitted between a pair of devices 502, 504, 506 and/or 508 using two or more physical SLIMbus lines 556 and 558 and in multiple data slots 608, 610.Data sent over multiple SLIMbus data lines 556 and 558 and/or in multiple data slots 608, 610 may be time interleaved upon receipt.", "The data slots in the primary data frames 602 and in the secondary data frames 604 may be associated with a common clock cycle, configured by information provided in the framing slot 604, 606.As a result, the data may be sent over the first and second SLIMbus data lines 556 and 558 synchronously, in parallel, simultaneously, and/or substantially simultaneously.", "During the framing slots 604 and 606, the second SLIMbus data line 558 may be idle.", "In some conventional implementations, certain data slots 616c and 618c of the secondary data frames 604 may be idled when corresponding data slots 608c, 608d, 610c and 610d are used for communications involving a device 508 that is not dual data line capable.", "According to certain aspects disclosed herein, other devices 502, 504 and 506 may attempt to establish private data communications channels utilizing the idle data slots 616c, 618c in the secondary data frames 612 by scheduling communication between themselves.", "It will be appreciated that this may result in systems in which the existence of communications channels on a second SLIMbus data line 558 is “hidden” from non-participating device 502, 504 or 506.Moreover, the existence of the secondary data line 558 may be concealed from legacy devices 508 that are compatible with a single SLIMbus data line.", "In some instances, the manager 550 may be responsible for scheduling and configuring data rates using a hidden second SLIMbus data line 558 even if the managing device 550 of the apparatus 500 is implemented on a legacy device 508 incapable of receiving communications over the second SLIMbus data line 558.The second scheduling diagram 620 illustrates an example of data communications in which the data slots 634, 636 of the secondary data frames 632, which correspond to the framing slots 626, 630 of the primary data frames 622, can be allocated to communications channels between SLIMbus components 502, 504, and/or 506 that are capable of receiving communications over the second SLIMbus data line 558.Bandwidth and throughput may be maximized for implementations where messaging and framing is coordinated for all SLIMbus data lines 556, 558.In some examples, data slots of the primary data frames 622 and the secondary data frames 632 may correspond to different clock cycles or bus cycles, and may have different timing.", "Therefore, in addition to sending data synchronously or in parallel as described with respect to the first scheduling diagram 600, data may be transmitted asynchronously between SLIMbus component 502, 504, 506 and/or 508.The SLIMbus component 502, 504, 506 and/or 508 may be configured to permit transmission from a single source SLIMbus component 502, 504, 506 and/or 508 to multiple destination SLIMbus component 502, 504, 506 and/or 508.For example, data may be transmitted from the second port 524 of Device B 504 to the second port 514 of Device A 502, and to the first port 532 of Device C 506 over the first SLIMbus data line 556 and the second SLIMbus data line 558 during the selected data slots 608, 610, 624 and 628.Scheduling for data communications between two or more SLIMbus ports 512, 514, 516, 522, 524, 526, 532, 534, 542 and/or 544 over one or more SLIMbus data lines 556 and 558 may be effected using a common bus cycle based on a centrally controlled clock.", "Certain aspects of conventional SLIMbus communications links may limit the ability of the technology to respond to demands for increased bandwidth and throughput.", "The rate of the data traffic that is needed for certain high bandwidth applications requires that a root frequency to be increased to 24.576 MHz or a higher multiple thereof in order to maintain bus efficiency and enable the continued use of isochronous transfer protocols.", "Isochronous data transfer can be used for the transmission of real-time data, including audio and video data.", "Isochronous transfer or transport protocols may be used to meet delivery requirements that require information to be delivered within a certain time period.", "However, increased root frequencies can lead to slew rate issues that affect the ability of a receiver to decode transmitted data.", "FIG.", "7 is a block diagram illustrating an example of an apparatus 700 that employs an expanded SLIMbus communications link 720 with a primary data line 724 and one or more (n) secondary data lines 726.The apparatus 700 may include devices 702, 704, 706 and 708 which have multiple data line capable SLIMbus components.", "The devices 702, 704, 706 and 708 may be provided in a single IC device, or may include one or more IC devices coupled to other circuits and disposed upon a chip carrier, circuit board or within a single package, for example.", "According to certain aspects disclosed herein, communications channels may be implemented using some combination of the primary data line 724 and one or more of the secondary data lines 726 that carry messages in compliance with SLIMbus specifications, and/or one or more of the secondary data lines 726 configured to carry messages on non-SLIMbus communications channels.", "In some examples, secondary data lines 726 may be configured to provide a decentralized or private SLIMbus communications channels to further improve available bandwidth and throughput within the apparatus 700.In some instances, a plurality of the n secondary data lines 726 may be used for directly connecting two or more devices 702, 704, 706 and 708.In one example, one or more of the n secondary data lines 726 may be reserved for communications between two or more of the devices 702, 704, 706 and 708, while at least the primary data line 724 is monitored and/or used for communication by all of the devices 702, 704, 706 and 708.Timing of each of the secondary data lines 726 may be configured to follow the same relationship as the clock line and the primary data line 724.In one example, secondary data lines 726 do not carry any control information and all devices 702, 704, 706 and 708 can maintain bus synchronization based on signaling associated with the primary data line 724.Accordingly, there may be no necessity to synchronize the n secondary data lines 726 with one another, or to handle loss of synchronization on one of the secondary data lines 726.Each device 702, 704, 706 and 708 may include a framer module in the Frame Layer 712, 714, 716 and 718.A management module (Manager) 710 may be operated on one of the devices 702, 704, 706 or 708.FIG.", "8 illustrates an example of a SLIMbus communications link 820 that connects a plurality of multiple SLIMbus data line capable devices 802, 804, 806 and at least one single data line capable SLIMbus device 808.In this example, a manager 810 may be active on the device or component 808 that supports only a primary data line 824, although the manager 810 may control configuration and operation of multiple secondary data lines 826 and a clock signal 822 used by other devices 802, 804, 806.FIG.", "9 is a block diagram 900 illustrating an example of an apparatus in which communications between a plurality of IC devices 902, 904, 906, 908, 910 and 912 is facilitated by a flexibly configurable data communications link 928.In the example, the plurality of the IC devices 902, 904, 906, 908, 910 and 912 may be configured to communicate according to a SLIMbus protocol.", "In one example, some or all of the plurality of the IC devices 902, 904, 906, 908, 910 and 912 may transmit, receive and/or monitor communications on at least a primary SLIMbus data line 932.Some or all of the plurality of the IC devices 902, 904, 906, 908, 910 and 912 may receive timing information from the SLIMbus clock 930.Accordingly, each of the IC devices 902, 904, 906, 908, 910, and 912 may include a framer 914, 916, 918, 920, 922, and 924 configured to receive and/or transmit information according to SLIMbus protocols and timing.", "The information may include configuration and timing information generated by a manager component 926.For example, the configuration and timing information may include setup and other parameters maintained and/or reported by each of the plurality of the IC devices 902, 904, 906, 908, 910 and 912, and timeslot allocations provided by the manager 926.In one example, the manager 926 may receive configuration parameters reported by some or all of the IC devices 902, 904, 906, 908, 910 and 912 indicating availability of single-line or multi-line SLIMbus data transmission and reception capabilities.", "In another example, one or more of the IC devices 902, 904, 906, 908, 910 and 912 may report the presence of a hidden secondary data line 936, 938 that may be used for private or direct communications channels between two or more devices.", "The private or direct communications channels may be operated using SLIMbus protocols synchronized with the SLIMbus clock 930 and/or may be operated using a different time-division or non-time division protocol that may be synchronized based on the SLIMbus clock 930, at the frame level, or not synchronized with SLIMbus operations.", "In another example, the manager 926 may allocate communications channels on secondary data lines 934, 936 and 938 for the use of pairs or groups of the plurality of the IC devices 902, 904, 906, 908, 910 and 912.Accordingly, dedicated secondary data lines 936 and 938 may be connected to all of the IC devices 902, 904, 906, 908, 910 and 912, but monitored and/or used by only a few of the IC devices 902, 904, 906, 908, 910 and 912.For example, the manager 926 may configure the data link such that a secondary data line 936 is available for the sole use of a first pair of IC devices 910 and 912, while a second secondary data line 938 is restricted or otherwise available for the sole use of a second pair of IC devices 904 and 906.In each of these examples, configuration, timing and global multicast communications (i.e., between all of the IC devices 902, 904, 906, 908, 910 and 912) may be restricted to the primary data line 932.The primary data line 932 and a common secondary data line 934 may be used to carry communications channels between those IC devices 902, 904, 906, 910 and 912 that are capable of multi-line communication and that are connected to the common secondary data line 934.The common secondary data line 934 may be used for multicast messages directed to any subset of the IC devices 902, 904, 906, 910 and 912 that is connected to the common secondary data line 934.The clock signal 930 may serve as a master clock used to synchronize one or more clocks that provide timing for signaling on corresponding data lines 932, 934, 936 and 938.In some examples, signaling on each data line 932, 934, 936 and/or 938 may be derived from or synchronized to the SLIMbus clock 930.The data link 928 may be implemented as a physical bus having multiple data lines 932, 934, 936, 938, whereby the IC devices 902, 904, 906, 908, 910 and 912 may selectively be physically connected to some configuration of the data lines 932, 934, 936, 938.Thus, the first private channel between IC devices 910 and 912 may be implemented by physically connecting the IC devices 910 and 912 to the S1 secondary data line 936, where the remaining IC devices 902, 904, 906 and 908 are not connected to the S1 secondary data line 936.Alternatively or additionally, a private channel may be constructed by causing only the subject pair of IC devices 910 and 912 to connect, monitor and/or otherwise use the S1 secondary data line 936.The channelization of a common data line 932, 934 according to a time-division protocol allows the common data line 932, 934 to be used as a private channel for a larger number of IC devices 902, 904, 906, 908, 910 and 912, which are configured to use the common primary data line 932 or secondary data line 934 (for example) only during an allocated time slot.", "The data communications link 928 may be adapted or configured to implement a broad range of topologies.", "Available topologies may include point-to-point secondary data lines 936, 938 provided privately between pairs of the IC devices 902, 904, 906, 908, 910 and 912 and/or multipoint secondary data lines 936, 938 provided privately between trios and other combinations of the IC devices 902, 904, 906, 908, 910 and 912.In some topologies, legacy single data line capable IC devices 908 may be provisioned with a signal line 840 configured to communicate with one or more other IC devices 902, 904, 906, 910 and 912 through a secondary data line 934, 936 or 938.For example, the legacy IC device 908 may be coupled to the S1 secondary data line 936 (or to any other secondary data line 934, 938) using a different protocol and/or type of physical connection and may receive configuration information indirectly through another multiple data line capable IC device 910 and/or 912 as well as through the primary data line 932.The legacy IC device 908 may be configured and operated as a slave to the multiple data line capable IC device 910 and/or 912 or the multiple data line capable IC device 910 and/or 912 may pass through configuration and other information from the manager 926.A hierarchical network may be constructed that optimizes communications based on priority, data rates, quality of service requirements and profiles of sources and/or destinations for communications associated with the IC devices 902, 904, 906, 908, 910 and 912.In one example, communications over the S1 secondary data line 936 may be clocked at lower rates than data is clocked on the primary data line 932 or the common secondary data line 934, and the connection of the legacy IC device 908 through another IC device 910 or 912 may improve overall system throughput.", "In another example, the legacy IC device 908 may be connected to a secondary data line 934, 936, or 938 that operates according to a lower rate clock than the primary data line 932, such that the primary data line 932 can operate at an optimal or highest clock rate while the legacy IC device 908 can communicate at a rate consistent with its capabilities.", "The data communications link 928 may be configured by a process consistent with SLIMbus protocols.", "For example, the manager 926 may transmit configuration and/or programming messages to each IC device 902, 904, 906, 908, 910 and/or 912.The configuration and/or programming messages may define the topology, clock rates and communication channel allocations to timeslots and data lines from the perspective of each IC device 902, 904, 906, 908, 910 and 912.After configuration/programming messages have been transmitted to each IC device 902, 904, 906, 908, 910 and 912, a “RECONFIG_NOW” message may be transmitted to each IC device 902, 904, 906, 908, 910 and 912.In response to receiving the “RECONFIG_NOW” message, each of the IC devices 902, 904, 906, 908, 910 and 912 may begin operating in accordance with the most recently received configuration/programming message at the next appropriate frame boundary.", "In some examples, the “RECONFIG_NOW” message may be used to synchronize configuration/programming of the SLIMbus components.", "Configuration can be defined independently for individual IC devices 902, 904, 906, 908, 910 and 912, pairs of IC devices 902, 904, 906, 908, 910 and 912, or other sized groups or sets of IC devices 902, 904, 906, 908, 910 and 912.Configuration information may be provided in multiple stages, such that one or more IC devices 902, 904, 906, 908, 910 and 912 may be configured individually and may receive additional configuration or reconfiguration of certain parameters in one or more group configuration/programming messages.", "Furthermore, a “RECONFIG_NOW” message may be used to provoke selective response by one or more IC devices 902, 904, 906, 908, 910 and 912 based on which devices or pairs, trios and other groups or sets of IC devices 902, 904, 906, 908, 910 and 912 are addressed by the “RECONFIG_NOW” message.", "As shown in FIG.", "6, framing and control slots 634 and 636 may be used for data transmission on a secondary data line 934, 936 and/or 938, while framing and control information is transmitted in corresponding slots 626 and 630 on the primary data line 932.In some examples, the slots 634 and 636 on a secondary data line 934, 936 and/or 938 may be reserved for framing and control information when a downstream IC device 908 relies on an upstream IC device 910 or 912 to relay framing and control information from the manager 926.In some instances, the framing and control information transmitted on the secondary data line 934, 936 and/or 938 may be reformatted before transmission in order to accommodate legacy IC devices 908.In some examples, the framing and control information transmitted on the secondary data line 934, 936 and/or 938 may be reformatted when the secondary data line 934, 936 and/or 938 is operated in accordance with a non-SLIMbus protocol.", "One or more secondary data lines 934, 936 and/or 938 may be reserved for non-SLIMbus data channels.", "In such instances, a modified framing and startup process may be employed for secondary data lines 934, 936 and/or 938 that are reserved for non-SLIMbus data channels.", "The general startup and framing procedures used for SLIMbus data lines 932, 934, 936 and/or 938 may be adapted for use with non-SLIMbus data channels.", "In one example, these general startup framing procedures include causing the secondary data lines 934, 936 and/or 938 to become inactive whereby any component that is not in an operational state refrains from driving a secondary data line 934, 936 and/or 938, such that data on the secondary data lines 934, 936 and/or 938 is only transmitted/received after a data channel has been configured by the Manager 926.Secondary data lines 934, 936 and/or 938 may start in a low logic state to ensure proper Non-Return-to-Zero Inverted (NRZI) encoding and decoding at each of the SLIMbus devices 902, 904, 906, 908, 910 and/or 912.In a SLIMbus interface, all SLIMbus devices 902, 904, 906, 908, 910 and/or 912 are required to listen to the primary data line 932 to ensure that synchronization and control information is captured.", "The SLIMbus infrastructure for a data communications link 928 that has multiple secondary data lines 934, 936 and 938 can remain identical or comparable to a single data line SLIMbus implementation, regardless of the ability of connected SLIMbus devices 902, 904, 906, 908, 910 and/or 912 to support secondary lines.", "A secondary data line 934, 936 and/or 938 may have a topology that is different from the topology of the primary data line 932, or from any other secondary data line 934, 936 and/or 938.The manager 926 may correctly configure the data communications link 928 and allocate data channels when the manager 926 is aware of the capabilities and desired configuration of the SLIMbus devices 902, 904, 906, 908, 910 and/or 912.All data channels allocated by the manager 926 may be transmitted and/or received on a single data line 932.In one example, a data communications link 928 may be configured such that secondary data lines 934, 936 and 938 operate in parallel with the primary data line 932.The secondary data lines 934, 936 and 938 typically do not include control spaces such as time slots used for framing and control purposes.", "Accordingly, control space collisions are prevented on a secondary data line 934, 936 and/or 938, where a collision may refer to the result of a simultaneous transmission by two or more devices on a data bus that is operated using a multi-drop bus topology.", "Framing and control messages may be transmitted in channels on the primary data line 932.Secondary data lines 934, 936 and/or 938 may maintain the same control characteristics as the primary data line 932, including the root clock frequency, clock gear settings and so on.", "A superframe boundary, frame count, and slot counts may be calculated and maintained by components/devices based on signaling on the primary data line 932.Therefore, the SLIMbus devices 902, 904, 906, 908, 910 and/or 912 cannot typically lose superframe or Frame sync on a secondary line if it maintains synchronization with the primary data line 932.When the data communications link 928 is configured for a parallel distribution, channel allocation may be restricted to an even number of time slots.", "One or more dedicated information elements of a control/framing field may be assigned for configuring SLIMbus devices 902, 904, 906, 908, 910 and 912 to support additional secondary data lines.", "In one example, such information elements may be used for enumerating secondary data lines 934, 936 and/or 938.The SLIMbus protocol may be adapted to include additional control and framing messages when multiple secondary data lines 934, 936, 938 are used.", "In one example, the additional control and framing messages may include “NEXT_DEFINE_DATA_LINE,” “NEXT_EXTENDED_DEFINE_CHANNEL,” and/or other messages that may be used to allocate and/or configure data line numbers and channels.", "Legacy IC devices 908 that cannot support multiple data lines may respond with a negative acknowledgement (NACK) in response to such additional commands.", "FIG.", "10 is a conceptual diagram 1000 illustrating a simplified example of a hardware implementation for an apparatus employing a processing circuit 1002 that may be configured or adapted according to certain aspects disclosed herein.", "In accordance with various aspects of the disclosure, an element, or any portion of an element, or any combination of elements as disclosed herein may be implemented using the processing circuit 1002.The processing circuit 1002 may include one or more processors 1004 that are controlled by some combination of hardware and software modules.", "Examples of processors 1004 include microprocessors, microcontrollers, digital signal processors (DSPs), field programmable gate arrays (FPGAs), programmable logic devices (PLDs), state machines, sequencers, gated logic, discrete hardware circuits, and other suitable hardware configured to perform the various functionality described throughout this disclosure.", "The one or more processors 1004 may include specialized processors that perform specific functions, and that may be configured, augmented or controlled by one of the software modules 1016.The one or more processors 1004 may be configured through a combination of software modules 1016 loaded during initialization, and further configured by loading or unloading one or more software modules 1016 during operation.", "In the illustrated example, the processing circuit 1002 may be implemented with a bus architecture, represented generally by the bus 1010.The bus 1010 may include any number of interconnecting buses and bridges depending on the specific application of the processing circuit 1002 and the overall design constraints.", "The bus 1010 links together various circuits including the one or more processors 1004, and storage 1006.Storage 1006 may include memory devices and mass storage devices, and may be referred to herein as computer-readable media and/or processor-readable media.", "The bus 1010 may also link various other circuits such as timing sources, timers, peripherals, voltage regulators, and power management circuits.", "A bus interface 1008 may provide an interface between the bus 1010 and one or more transceivers 1012.A transceiver 1012 may be provided for each networking technology supported by the processing circuit.", "In some instances, multiple networking technologies may share some or all of the circuitry or processing modules found in a transceiver 1012.Each transceiver 1012 provides a means for communicating with various other apparatus over a transmission medium.", "Depending upon the nature of the apparatus, a user interface 1018 (e.g., keypad, display, speaker, microphone, joystick) may also be provided, and may be communicatively coupled to the bus 1010 directly or through the bus interface 1008.A processor 1004 may be responsible for managing the bus 1010 and for general processing that may include the execution of software stored in a computer-readable medium that may include the storage 1006.In this respect, the processing circuit 1002, including the processor 1004, may be used to implement any of the methods, functions and techniques disclosed herein.", "The storage 1006 may be used for storing data that is manipulated by the processor 1004 when executing software, and the software may be configured to implement any one of the methods disclosed herein.", "One or more processors 1004 in the processing circuit 1002 may execute software.", "Software shall be construed broadly to mean instructions, instruction sets, code, code segments, program code, programs, subprograms, software modules, applications, software applications, software packages, routines, subroutines, objects, executables, threads of execution, procedures, functions, algorithms, etc., whether referred to as software, firmware, middleware, microcode, hardware description language, or otherwise.", "The software may reside in computer-readable form in the storage 1006 or in an external computer readable medium.", "The external computer-readable medium and/or storage 1006 may include a non-transitory computer-readable medium.", "A non-transitory computer-readable medium includes, by way of example, a magnetic storage device (e.g., hard disk, floppy disk, magnetic strip), an optical disk (e.g., a compact disc (CD) or a digital versatile disc (DVD)), a smart card, a flash memory device (e.g., a “flash drive,” a card, a stick, or a key drive), a random access memory (RAM), a read only memory (ROM), a programmable ROM (PROM), an erasable PROM (EPROM), an electrically erasable PROM (EEPROM), a register, a removable disk, and any other suitable medium for storing software and/or instructions that may be accessed and read by a computer.", "The computer-readable medium and/or storage 1006 may also include, by way of example, a carrier wave, a transmission line, and any other suitable medium for transmitting software and/or instructions that may be accessed and read by a computer.", "Computer-readable medium and/or the storage 1006 may reside in the processing circuit 1002, in the processor 1004, external to the processing circuit 1002, or be distributed across multiple entities including the processing circuit 1002.The computer-readable medium and/or storage 1006 may be embodied in a computer program product.", "By way of example, a computer program product may include a computer-readable medium in packaging materials.", "Those skilled in the art will recognize how best to implement the described functionality presented throughout this disclosure depending on the particular application and the overall design constraints imposed on the overall system.", "The storage 1006 may maintain software maintained and/or organized in loadable code segments, modules, applications, programs, etc., which may be referred to herein as software modules 1016.Each of the software modules 1016 may include instructions and data that, when installed or loaded on the processing circuit 1002 and executed by the one or more processors 1004, contribute to a run-time image 1014 that controls the operation of the one or more processors 1004.When executed, certain instructions may cause the processing circuit 1002 to perform functions in accordance with certain methods, algorithms and processes described herein.", "Some of the software modules 1016 may be loaded during initialization of the processing circuit 1002, and these software modules 1016 may configure the processing circuit 1002 to enable performance of the various functions disclosed herein.", "For example, some software modules 1016 may configure internal devices and/or logic circuits 1022 of the processor 1004, and may manage access to external devices such as the transceiver 1012, the bus interface 1008, the user interface 1018, timers, mathematical coprocessors, and so on.", "The software modules 1016 may include a control program and/or an operating system that interacts with interrupt handlers and device drivers, and that controls access to various resources provided by the processing circuit 1002.The resources may include memory, processing time, access to the transceiver 1012, the user interface 1018, and so on.", "One or more processors 1004 of the processing circuit 1002 may be multifunctional, whereby some of the software modules 1016 are loaded and configured to perform different functions or different instances of the same function.", "The one or more processors 1004 may additionally be adapted to manage background tasks initiated in response to inputs from the user interface 1018, the transceiver 1012, and device drivers, for example.", "To support the performance of multiple functions, the one or more processors 1004 may be configured to provide a multitasking environment, whereby each of a plurality of functions is implemented as a set of tasks serviced by the one or more processors 1004 as needed or desired.", "In one example, the multitasking environment may be implemented using a timesharing program 1020 that passes control of a processor 1004 between different tasks, whereby each task returns control of the one or more processors 1004 to the timesharing program 1020 upon completion of any outstanding operations and/or in response to an input such as an interrupt.", "When a task has control of the one or more processors 1004, the processing circuit is effectively specialized for the purposes addressed by the function associated with the controlling task.", "The timesharing program 1020 may include an operating system, a main loop that transfers control on a round-robin basis, a function that allocates control of the one or more processors 1004 in accordance with a prioritization of the functions, and/or an interrupt driven main loop that responds to external events by providing control of the one or more processors 1004 to a handling function.", "FIG.", "11 is a flowchart illustrating a communications method according to certain aspects of the invention.", "The method may be performed by a device 902 that includes a manger circuit or module 926.At step 1102, the device 902 may determine communications capabilities of a first device coupled to a SLIMbus.", "The communications capabilities may identify a number of data wires coupled to the first device.", "At step 1104, the device 902 may send a configuration message and/or a framing message to the first device over a primary data line of the SLIMbus.", "The configuration message may include control information reserving the secondary data line for communications between the first device and the second device.", "The secondary data line may be one of a plurality of secondary data lines of the SLIMbus.", "The control information may be generated by a SLIMbus manager provided on a third device.", "The third device may be restricted to communicating over the primary data line.", "In some examples, the control information may be generated by a SLIMbus manager provided on one of the first and second devices.", "The configuration message may include a framing message.", "In an aspect of the disclosure, the configuration message may cause the first device to be configured for communication with a second device over a secondary data line.", "In one example, the first device may be configured to communicate with the second device using a SLIMbus protocol.", "In another example, the first device may be configured to communicate with the second device using a non-SLIMbus protocol.", "The secondary data line may connect the first device with the second device independently of the SLIMbus.", "At step 1106, the device 902 may provide a clock signal that controls timing of transmission on at least the primary data line.", "Communications on the secondary data line may be synchronized using the clock signal.", "In an aspect of the disclosure, a plurality of communications channels in time slots on both the primary data line and the secondary data line data may be allocated.", "The first device may communicate with the second device using one of the plurality of communications channels.", "In an aspect of the disclosure, configuration messages sent over the primary data line to a plurality of devices.", "The reconfiguration command may cause each of the plurality of devices to adopt a configuration in accordance with at least one configuration message.", "At least one configuration message sent over the primary data line may be addressed to a predefined set of devices.", "In an aspect of the disclosure, the first device may be configured to relay at least one configuration message sent over the primary data line to a third device that is not connected to the primary data line.", "FIG.", "12 is a conceptual diagram illustrating an example of a hardware implementation for an apparatus 1200 employing a processing circuit 1202.In this example, the processing circuit 1202 may be implemented with a bus architecture, represented generally by the bus 1216.The bus 1216 may include any number of interconnecting buses and bridges depending on the specific application of the processing circuit 1202 and the overall design constraints.", "The bus 1216 links together various circuits including one or more processors, represented generally by the processor 1212, and computer-readable media, represented generally by the processor-readable storage medium 1214.The bus 1216 may also link various other circuits such as timing sources, timers, peripherals, voltage regulators, and power management circuits.", "A bus interface 1218 provides an interface between the bus 1216 and a transceiver 1220.The transceiver 1220 may include a bus interface that provides a means for communicating with various other apparatus over a transmission medium.", "Depending upon the nature of the apparatus, a user interface 1222 (e.g., keypad, display, speaker, microphone, joystick) may also be provided.", "One or more clock circuits or modules 1206 may be provided within the processing circuit 1202 or controlled by processing circuit 1202 and/or one or more processors 1212.In one example, the clock circuits or modules 1206 may include one or more crystal oscillators, one or more phase-locked loop devices, and/or one or more configurable clock trees.", "The processor 1212 is responsible for managing the bus 1216 and general processing, including the execution of software stored on the processor-readable storage medium 1214.The software, when executed by the processor 1212, causes the processing circuit 1202 to perform the various functions described supra for any particular apparatus.", "The processor-readable storage medium 1214 may be used for storing data that is manipulated by the processor 1212 when executing software.", "In one configuration, the apparatus 1200 may be coupled to a SLIMbus 1224 and may include modules or circuits 1204 for determining communications capabilities of other devices coupled to the SLIMbus 1224, modules or circuits 1210, 1226 adapted or configured to send configuration and framing messages to one or more devices over a primary data line of the SLIMbus 1224, and clock generating modules or circuits 1206 that provide a clock signal that controls timing of transmissions on at least the primary data line of the SLIMbus 1224.Configuration and SLIMbus management modules or circuits 1208, 1210 may cooperate to define and/or allocate a plurality of communications channels in time slots on a primary data line and/or a secondary data line of the SLIMbus 1224.In one example, the apparatus 1200 may include interface module and/or circuits 1226 that implements framing and control for the SLIMbus 1224.In some instances, a manager module or circuit may 1210 may control the operation of various circuits and modules 1204, 1206, 1208, and may be responsible for configuring the SLIMbus 1224 and other apparatus connected to the SLIMbus 1224.FIG.", "13 is a flowchart illustrating a communications method according to certain aspects of the invention.", "The method may be performed by a device 910, 912 that supports communication over a plurality of data lines 932, 934, 936, 940.At step 1302, the device 910, 912 may receive one or more configuration messages from a SLIMbus primary data line.", "At step 1304, the device 910, 912 may reconfigure a communications interface in response to a reconfiguration command and based on the one or more configuration messages.", "At step 1306, the device 910, 912 may communicate with a first device over a first data line while communicating with a second device over a second data line.", "The second data line may be reserved for communications with the second device.", "The first data line may include the SLIMbus primary data line or a SLIMbus secondary data line.", "The second data line may be a SLIMbus secondary data line that employs a framing and control configuration used by the SLIMbus primary data line.", "The framing and control configuration may define a root clock frequency.", "The framing and control configuration may define gearing and is used to calculate a frame boundary.", "Communications on the second data line may be controlled by a non-SLIMbus protocol.", "In an aspect of the disclosure, communications capabilities information may be reported to a manager device.", "The configuration messages may be generated in response to the communications capabilities information.", "FIG.", "14 is a conceptual diagram illustrating an example of a hardware implementation for an apparatus 1400 employing a processing circuit 1402.In this example, the processing circuit 1402 may be implemented with a bus architecture, represented generally by the bus 1416.The bus 1416 may include any number of interconnecting buses and bridges depending on the specific application of the processing circuit 1402 and the overall design constraints.", "The bus 1416 links together various circuits including one or more processors, represented generally by the processor 1412, and computer-readable media, represented generally by the processor-readable storage medium 1414.The bus 1416 may also link various other circuits such as timing sources, timers, peripherals, voltage regulators, and power management circuits.", "A bus interface 1418 provides an interface between the bus 1416 and a transceiver 1420.The transceiver 1420 may include a bus interface that provides a means for communicating with various other apparatus over a transmission medium.", "Depending upon the nature of the apparatus, a user interface 1422 (e.g., keypad, display, speaker, microphone, joystick) may also be provided.", "One or more clock circuits or modules 1406 may be provided within the processing circuit 1402 or controlled by processing circuit 1402 and/or one or more processors 1412.In one example, the clock circuits or modules 1406 may include one or more crystal oscillators, one or more phase-locked loop devices, and/or one or more configurable clock trees.", "The processor 1412 is responsible for managing the bus 1416 and general processing, including the execution of software stored on the processor-readable storage medium 1414.The software, when executed by the processor 1412, causes the processing circuit 1402 to perform the various functions described supra for any particular apparatus.", "The processor-readable storage medium 1414 may be used for storing data that is manipulated by the processor 1412 when executing software.", "In one configuration, the apparatus 1400 includes modules or circuits 1404, 1410, 1426 for reporting a configuration including communications capabilities of the apparatus 1400 to a SLIMbus manager, modules or circuits 1410 for receiving one or more configuration messages from a primary data line of a SLIMbus 1424, modules or circuits 1408 for reconfiguring a communications interface 1426, and modules or circuits 1410, 1426 for communicating with a first device over a first data line of the SLIMbus 1424 while communicating with a second device over a second data line of the SLIMbus 1424 The aforementioned means, modules and circuits may be implemented, for example, using some combination of a processor 206 or 236, physical layer drivers 210 or 240 and storage media 208 and 238 illustrated in FIG.", "2 and deployed in a network configuration illustrated by FIG.", "9.It is understood that the specific order or hierarchy of steps in the processes disclosed is an illustration of exemplary approaches.", "Based upon design preferences, it is understood that the specific order or hierarchy of steps in the processes may be rearranged.", "The accompanying method claims present elements of the various steps in a sample order, and are not meant to be limited to the specific order or hierarchy presented.", "The previous description is provided to enable any person skilled in the art to practice the various aspects described herein.", "Various modifications to these aspects will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other aspects.", "Thus, the claims are not intended to be limited to the aspects shown herein, but is to be accorded the full scope consistent with the language claims, wherein reference to an element in the singular is not intended to mean “one and only one” unless specifically so stated, but rather “one or more.” Unless specifically stated otherwise, the term “some” refers to one or more.", "All structural and functional equivalents to the elements of the various aspects described throughout this disclosure that are known or later come to be known to those of ordinary skill in the art are expressly incorporated herein by reference and are intended to be encompassed by the claims.", "Moreover, nothing disclosed herein is intended to be dedicated to the public regardless of whether such disclosure is explicitly recited in the claims.", "No claim element is to be construed as a means plus function unless the element is expressly recited using the phrase “means for.”" ] ]
Patent_15875937
[ [ "PROCESS FOR PREPARING 3-[(4S)-8-BROMO-1-METHYL-6-(2-PYRIDINYL)-4H-IMIDAZO[1,2-a][1,4]BENZODIAZEPIN-4-YL]PROPIONIC ACID METHYL ESTER BENZENESULFONATE", "A process for preparing 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4,-benzodiazepin-3-yl]propionic acid methyl ester at a high conversion rate with good reproducibility by oxidizing 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester in the presence of an oxidation catalyst is provided by defining the ammonium ion content of 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester." ], [ "1-16.", "(canceled) 17.A process for preparing 3-[(S)-7-bromo-2-((2-oxopropyl)amino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester represented by the formula (FK) comprising: (a) reacting a compound of formula (D), with a compound selected from 1-amino-2-propanol, (R)-1-amino-2-propanol, and (S)-1-amino-2-propanol to provide an intermediate compound; and (b) reacting said intermediate compound with at least one oxidizing agent in the presence of at least one oxidation catalyst, wherein said at least one oxidation catalyst is selected from the group consisting of: (i) 2,2,6,6-tetramethylpiperidin-1-ol; (ii) 2,2,6,6-tetramethylpiperidine-1,4-diol; and (iii) a compound of formula (I-1): wherein: R1, R2, and R5 independently represent hydrogen, halogen, hydroxy, C1-3 alkyl or C1-3 alkoxy; R3 represents hydrogen or halogen; and X═R4 represents N—O*, N—OH, or N+═O; wherein the reaction of the intermediate compound with said at least one oxidizing agent and said at least one oxidation catalyst is conducted in a reaction system satisfying at least one of the following conditions (x), (y) and (z): (x) in the absence of an ammonium ion; (y) in the presence of an ammonium ion in a weight ratio of 170 ppm or less relative to the compound; and (z) in the presence of an ammonium ion in a molar ratio of 145% or less relative to the oxidation catalyst.", "18.The process according to claim 17, wherein said oxidation catalyst is selected from 2-azaadamantane-N-oxyl and 2-azaadamantan-2-ol.", "19.The process according to claim 17, wherein said oxidizing agent is sodium hypochlorite.", "20.The process according to claim 17, wherein said oxidizing agent is sodium hypochlorite and said oxidation catalyst is selected from 2-azaadamantane-N-oxyl and 2-azaadamantan-2-ol.", "21.The process according to claim 17, wherein said reaction of said intermediate compound with at least one oxidizing agent in the presence of at least one oxidation catalyst is conducted in a solvent comprising an aprotic solvent.", "22.The process according to claim 21, wherein said solvent comprises methyl acetate or toluene, or a mixture thereof.", "23.The process according to claim 21, wherein said solvent further comprises water." ], [ "<SOH> BACKGROUND ART <EOH>Each reaction step for preparing an active pharmaceutical ingredient should be a step that proceeds with a good reaction yield, is conducted with good reproducibility, can provide a high-purity product, and is thus suited for industrial production.", "Impurities which have appeared in each preparation process can be removed in a purification step, but a preparation process having such a purification step is not always a process suited for industrial production, because the purification step makes the work cumbersome and reduces a working efficiency.", "Moreover, an increase in the frequency of the purification step may reduce a total yield of a desired active pharmaceutical ingredient.", "There is therefore a demand for the establishment of a preparation process in which the number of purification steps is reduced as much as possible and which, as described above, proceeds with a good reaction yield, provides a high-purity product with good reproducibility, and is thus suited for industrial production.", "3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2,-a][1,4]benzodiazepin-4-yl]propionic acid methyl ester benzenesulfonate is a compound having sedative and anesthetic actions.", "Patent Document 1 that discloses a preparation process of the compound describes a process for preparing 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester by subjecting 3-[(S)-7-bromo-2-((R)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]-diazepin-3-yl]propionic acid methyl ester purified by recrystallization to Dess-Martin (Dess-Martin periodinane) oxidation or TEMPO (2,2,6,6-tetramethylpiperidin-N-oxyl) oxidation.", "The Dess-Martin oxidation or TEMPO oxidation used in the above process is a well-known process for converting a secondary alcohol compound into a corresponding ketone compound (Non-patent Documents 1 to 4).", "Although Dess-Martin oxidation is capable of oxidizing a secondary alcohol compound under mild conditions, it is not completely suited for the industrial level production, because as is already known, the reagent itself is potentially explosive.", "On the other hand, it is said that TEMPO oxidation can be conducted under mild conditions and is an oxidation reaction ordinarily usable in the industrial level production.", "It has however been pointed out that TEMPO oxidation of an aromatic ring-containing compound causes chlorination of the aromatic ring as a side reaction and this problem may lead to a reduction in yield of a target compound in TEMPO oxidation (refer to Non-patent Document 5).", "Thus, there is not known a industrially suited process for preparing 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester which is a synthesis intermediate of 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propionic acid methyl ester benzenesulfonate by oxidizing 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester, which is a raw material compound of the intended compound, safely with a high efficiency." ], [ "<SOH> SUMMARY OF INVENTION <EOH>" ], [ "FIELD OF THE INVENTION The present invention relates to a process for preparing 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester by subjecting, to an oxidation reaction, a compound selected from the group consisting of 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester, 3-[(S)-7-bromo-2-((R)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester, and 3-[(S)-7-bromo-2-((S)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester.", "More specifically, the present invention relates to a novel preparation process capable of providing 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester at a high conversion rate (reaction efficiency) with good reproducibility even when an oxidation reaction is conducted using, as a raw material, a compound selected from the group consisting of 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester, 3-[(S)-7-bromo-2-((R)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester, and 3-[(S)-7-bromo-2-((S)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester which are each an unpurified compound.", "BACKGROUND ART Each reaction step for preparing an active pharmaceutical ingredient should be a step that proceeds with a good reaction yield, is conducted with good reproducibility, can provide a high-purity product, and is thus suited for industrial production.", "Impurities which have appeared in each preparation process can be removed in a purification step, but a preparation process having such a purification step is not always a process suited for industrial production, because the purification step makes the work cumbersome and reduces a working efficiency.", "Moreover, an increase in the frequency of the purification step may reduce a total yield of a desired active pharmaceutical ingredient.", "There is therefore a demand for the establishment of a preparation process in which the number of purification steps is reduced as much as possible and which, as described above, proceeds with a good reaction yield, provides a high-purity product with good reproducibility, and is thus suited for industrial production.", "3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2,-a][1,4]benzodiazepin-4-yl]propionic acid methyl ester benzenesulfonate is a compound having sedative and anesthetic actions.", "Patent Document 1 that discloses a preparation process of the compound describes a process for preparing 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester by subjecting 3-[(S)-7-bromo-2-((R)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]-diazepin-3-yl]propionic acid methyl ester purified by recrystallization to Dess-Martin (Dess-Martin periodinane) oxidation or TEMPO (2,2,6,6-tetramethylpiperidin-N-oxyl) oxidation.", "The Dess-Martin oxidation or TEMPO oxidation used in the above process is a well-known process for converting a secondary alcohol compound into a corresponding ketone compound (Non-patent Documents 1 to 4).", "Although Dess-Martin oxidation is capable of oxidizing a secondary alcohol compound under mild conditions, it is not completely suited for the industrial level production, because as is already known, the reagent itself is potentially explosive.", "On the other hand, it is said that TEMPO oxidation can be conducted under mild conditions and is an oxidation reaction ordinarily usable in the industrial level production.", "It has however been pointed out that TEMPO oxidation of an aromatic ring-containing compound causes chlorination of the aromatic ring as a side reaction and this problem may lead to a reduction in yield of a target compound in TEMPO oxidation (refer to Non-patent Document 5).", "Thus, there is not known a industrially suited process for preparing 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester which is a synthesis intermediate of 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propionic acid methyl ester benzenesulfonate by oxidizing 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester, which is a raw material compound of the intended compound, safely with a high efficiency.", "PRIOR ART DOCUMENT Patent Document [Patent Document 1] WO 2011/032692 Non-Patent Documents [Non-patent Document 1] Journal of the American Chemical Society, 128, 8412-8413(2006) [Non-patent Document 2] Journal of the American Chemical Society, 133, 6497-6500(2011) [Non-patent Document 3] Chemical & Pharmaceutical Bulletin, 59, 1570-1573(2011) [Non-patent Document 4] Synthesis, 20, 3545-3555(2010) [Non-patent Document 5] Journal of Organic Chemistry, 64, 2564-2566(1999) SUMMARY OF INVENTION Problems that the Invention is to Solve The present inventors have studied, by using various oxidation catalysts, the safety and reaction efficiency of an oxidation method of 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester (which may hereinafter be abbreviated as “Compound (EM)”) for safely and efficiently obtaining 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester (which may hereinafter be abbreviated as “Compound (FK)”) which is a synthesis intermediate of 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]-benzodiazepin-4-yl]propionic acid methyl ester benzenesulfonate (which may hereinafter be abbreviated as “Compound (P)”) having sedative and anesthetic actions.", "The study suggested that a good result can be obtained by using AZADO (2-azaadamantane-N-oxyl) that similar to TEMPO, belongs to N-oxyl oxidation catalysts.", "It has however been revealed that when an oxidation reaction using AZADO is repeated, reproducibility of a conversion rate (reaction efficiency) cannot be achieved for some reasons in spite of the reaction repeated under the same conditions.", "In short, an object of the present invention is to find a reason why reproducibility of a conversion rate (reaction efficiency) cannot be achieved in an oxidation reaction using AZADO and establish an oxidation method of Compound (EM) which is capable of preparing Compound (FK) at a high conversion rate (reaction efficiency) with good reproducibility, safe, highly efficient, and applicable to industrial production.", "Means for Solving the Problems With a view to achieving the above-mentioned object, the present inventors have extensively studied the reason why the reproducibility of a conversion rate (reaction efficiency) was not achieved in an oxidation reaction using AZADO.", "As a result, it has been found that a slight amount of an ammonium ion mixed in the reaction system impedes the oxidation reaction.", "The study has been made further to find that an oxidation reaction is conducted at a high conversion rate (reaction efficiency) with excellent reproducibility by reducing the amount of an ammonium ion present in the reaction system to a certain amount or less; that reduction of the amount of an ammonium ion can be applied not only to oxidation reactions using AZADO but also to general oxidation reactions using AZADO analogs; and that this reduction can be applied even to general oxidation reactions using N-oxyl oxidation catalysts including TEMPO, leading to the completion of the present invention.", "Described specifically, the present invention relates to: [1] a process for preparing 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester (Compound (FK)) by subjecting, to an oxidation reaction, a compound selected from the group consisting of 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester (“Compound (EM)”), 3-[(S)-7-bromo-2-((R)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester (which may hereinafter be abbreviated as “Compound (E)”), and 3-[(S)-7-bromo-2-((S)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester (which may hereinafter be abbreviated as “Compound (E′)”) in the presence of at least one oxidation catalyst selected from the group consisting of a compound represented by the following formula (I-1), (I-2) or (I-3): (wherein, R1, R2, and R5 each independently represent a hydrogen atom, a halogen, a hydroxyl group, a C1-3 alkyl group, or a C1-3 alkoxy group, R3 represents a hydrogen atom or a halogen, and XR4 represents N—O*, N—OH, or N+═O), 2,2,6,6-tetramethylpiperidin-N-oxyl, 2,2,6,6-tetramethylpiperidin-1-ol, 4-hydroxy-2,2,6,6-tetramethylpiperidin-N-oxyl, and 2,2,6,6-tetramethyl-1,4-piperidinediol, salts thereof, and solvates thereof, wherein the oxidation reaction is conducted in a reaction system satisfying at least one of the following conditions (a) to (c): (a) in the absence of an ammonium ion, (b) in the presence of an ammonium ion in a weight ratio of 170 ppm or less relative to the compound selected from the group consisting of Compound (EM), Compound (E), and Compound (E′) as a compound to be subjected to the oxidation reaction, and (c) in the presence of an ammonium ion in a molar ratio of 145% or less relative to the oxidation catalyst; [2] the preparation process as described above in [1], wherein the compound selected from the group consisting of Compound (EM), Compound (E), and Compound (E′) is an unpurified compound; [3] the preparation process as described above in [1] or [2], wherein the oxidation reaction is conducted at a conversion rate of 98% or more; [4] the preparation process as described above in any one of [1] to [3], wherein Compound (EM) is obtained by conducting an addition reaction between 3-[(S)-7-bromo-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propionic acid methyl ester (which may hereinafter be abbreviated as “Compound (D)”) and 1-aminopropan-2-ol, followed by washing; [5] the preparation process as described above in any one of [1] to [3], wherein Compound (E) is obtained by conducting an addition reaction between Compound (D) and (R)-1-aminopropan-2-ol, followed by washing; [6] the preparation process as described above in any one of [1] to [3], wherein Compound (E′) is obtained by conducting an addition reaction between Compound (D) and (S)-1-aminopropan-2-ol, followed by washing; [7] the preparation process as described above in any one of [4] to [6], wherein washing is conducted with a water soluble solution having a pH of from about 3.5 to about 10.5; [8] the preparation process as described above in [7], wherein the water soluble solution is an aqueous solution of ammonium chloride, an aqueous solution of sodium monohydrogen phosphate, an aqueous solution of sodium dihydrogen phosphate, and/or a phosphate buffer; [9] the preparation process as described above in any one of [1] to [8], wherein the oxidation catalyst is either 2-azaadamantane-N-oxyl or 2-azaadamantan-2-ol; [10] a process for preparing Compound (FK) by subjecting Compound (E) to an oxidation reaction in the presence of an oxidation catalyst which is either 2-azaadamantane-N-oxyl or 2-azaadamantan-2-ol, wherein the Compound (E) is a compound obtained by conducting an addition reaction between Compound (D) and (R)-1-aminopropan-2-ol, followed by washing with a phosphate buffer, [11] the preparation process as described above in [10], wherein Compound (E) is an unpurified compound; [12] Compound (FK), obtained by subjecting a compound selected from the group consisting of Compound (EM), Compound (E), and Compound (E′) to an oxidation reaction in the presence of at least one oxidation catalyst selected from the group consisting of a compound represented by the following formula (I-1), (I-2) or (I-3): (wherein, all the symbols have the same meanings as described above in [1]), 2,2,6,6-tetramethylpiperidin-N-oxyl, 2,2,6,6-tetramethylpiperidin-1-ol, 4-hydroxy-2,2,6,6-tetramethylpiperidin-N-oxyl, and 2,2,6,6-tetramethyl-1,4-piperidinediol, salts thereof, and solvates thereof, wherein the oxidation reaction is conducted in a reaction system satisfying at least one of the following conditions (a) to (c): (a) in the absence of an ammonium ion, (b) in the presence of an ammonium ion in a weight ratio of 170 ppm or less relative to the compound selected from the group consisting of Compound (EM), Compound (E), and Compound (E′) as a compound to be subjected to the oxidation reaction, and (c) in the presence of an ammonium ion in a molar ratio of 145% or less relative to the oxidation catalyst; [13] Compound (FK) as described above in [12], wherein the compound selected from the group consisting of Compound (EM), Compound (E), and Compound (E′) is an unpurified compound; [14] Compound (FK) as describe above in [12] or [13], wherein the oxidation reaction is conducted at a conversion rate of 98% or more; [15] Compound (FK) as described above in any one of [12] to [14], wherein Compound (EM) is obtained by conducting an addition reaction between Compound (D) and 1-aminopropan-2-ol, followed by washing; [16] Compound (FK) as described above in any one of [12] to [14], wherein Compound (E) is obtained by conducting an addition reaction between Compound (D) and (R)-1-aminopropan-2-ol, followed by washing; [17] Compound (FK) as described above in any one of [12] to [14], wherein Compound (E′) is obtained by conducting an addition reaction between Compound (D) and (S)-1-aminopropan-2-ol, followed by washing; [17] Compound (FK) as described above in any one of [15] to [17], wherein washing is conducted with a water soluble solution having a pH of from about 3.5 to about 10.5; [18] Compound (FK) as described above in [18], wherein the water soluble solution is an aqueous solution of ammonium chloride, an aqueous solution of sodium monohydrogen phosphate, an aqueous solution of sodium dihydrogen phosphate, and/or a phosphate buffer, [20] Compound (FK) as described above in any one of [12] to [19], wherein the oxidation catalyst is either 2-azaadamantane-N-oxyl or 2-azaadamantan-2-ol; [21] 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepin-4-yl]propionic acid methyl ester benzenesulfonate (Compound (P)), obtained by the following steps (i) to (iii): (i) a step of conducting an addition reaction between Compound (D) and (R)-1-aminopropan-2-ol and then washing with a phosphate buffer to obtain Compound (E); (ii) a step of subjecting Compound (E) obtained in the step (i) to an oxidation reaction in the presence of an oxidation catalyst which is either 2-azaadamantane-N-oxyl or 2-azaadamantan-2-ol to obtain Compound (FK); and (iii) a step of reacting Compound (FK) obtained in the step (ii) with benzenesulfonic acid to obtain Compound (P); [22] Compound (P) as described above in [21], wherein Compound (E) is an unpurified compound; [23] a reaction composition containing a compound selected from the group consisting of Compound (EM), Compound (E), and Compound (E′), an oxidizing agent, an oxidation catalyst, and a solvent, which contains no ammonium ion or contains an ammonium ion in a weight ratio of 170 ppm or less relative to the compound selected from the group consisting of Compound (EM), Compound (E), and Compound (E′) as the compound to be subjected to the oxidation reaction or in a molar ratio of 145% or less relative to the oxidation catalyst; [24] the reaction composition as described above in [23], for the preparation of Compound (FK); [25] the reaction composition as described above in [23] or [24], wherein the oxidation catalyst is selected from the group consisting of a compound represented by the following formula (I-1), (I-2) or (I-3): (wherein, all the symbols have the same meanings as described above in [1]), 2,2,6,6-tetramethylpiperidin-N-oxyl, 2,2,6,6-tetramethylpiperidin-1-ol, 4-hydroxy-2,2,6,6-tetramethylpiperidin-N-oxyl, and 2,2,6,6-tetramethyl-1,4-piperidinediol, salts thereof, and solvates thereof.", "Effect of the Invention According to the present invention, Compound (FK) can be prepared from a compound selected from the group consisting of Compound (EM), Compound (E), and Compound (E′), even if the compound is an unpurified compound, at a markedly high conversion rate and/or oxidation catalyst efficiency with good reproducibility.", "Described specifically, Compound (FK) can be prepared with good reproducibility and high efficiency by using as a starting material Compound (EM) whose ammonium ion remaining content has been defined and subjecting it to an oxidation reaction while using TEMPO, 2-azaadamantane-N-oxyl (which may hereinafter be abbreviated as “AZADO”) or an analog thereof, which will be described later as an oxidation catalyst.", "This Compound (FK) is an important synthesis intermediate of Compound (P) having both sedative and anesthetic actions.", "Since the preparation process of the present invention can stably supply Compound (FK) safely and with good reproducibility without conducting a particular purification step, it is very useful from the standpoint of industrial productivity of Compound (P) which is an active pharmaceutical ingredient.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a graph plotting an ammonium ion content and a conversion rate from Compound (E) to Compound (FK) in the present invention; and FIG.", "2 is a graph showing both the graph of FIG.", "1 and an approximate curve (linear approximation).", "MODE FOR CARRYING OUT THE INVENTION The present invention will hereinafter be described in detail.", "In the present invention, “3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]-benzodiazepin-4-yl]propionic acid methyl ester benzenesulfonate (Compound (P))” is a compound having a structure represented by the following formula: In the present invention, “3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester (Compound (FK))” is a compound having a structure represented by the following formula: In the present invention, “3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester (Compound (EM))” is a compound having a structure represented by the following formula: and is a mixture having, at any ratio, Compound (E) and Compound (E′) which will be described later.", "In the present invention, “3-[(S)-7-bromo-2-((R)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester (Compound (E))” is a compound having a structure represented by the following formula: In the present invention, “3-[(S)-7-bromo-2-((S)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester (Compound (E′))” is a compound having a structure represented by the following formula: In the present invention, “3-[(S)-7-bromo-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propionic acid methyl ester (Compound (D))” is a compound having a structure represented by the following formula: In the present invention, the term “halogen” means fluorine, chlorine, bromine, or iodine.", "In the present invention, the term “C1-3 alkyl group” means methyl, ethyl, n-propyl, or isopropyl.", "In the present invention, the term “C1-3 alkoxy group” means methoxy, ethoxy, n-propoxy, or isopropoxy.", "In the present invention, examples of the compound represented by the formula (I-1) include AZADO (another name: 2-azatricyclo[3.3.1.13,7]dec-2-yloxidanyl): 2-azaadamantane-N-oxoammonium cation (another name: 2-oxo-2-azoniatricyclo[3.3.1.13,7]decane) (which may hereinafter be abbreviated as “AZADO cation”): 2-azaadamantan-2-ol (another name: 2-azatricyclo[3.3.1.13,7]decan-2-ol) (which may hereinafter be abbreviated as “AZADOH”): 1-methyl-2-azaadamantan-N-oxyl (another name: (1-methyl-2-azatricyclo[3.3.1.13,7]dec-2-yl)oxidanyl) (which may hereinafter be abbreviated as “Me-AZADO”): 1-methyl-2-azaadamantane-N-oxoammonium cation (another name: 1-methyl-2-oxo-2-azoniatricyclo[3.3.1.13,7]decane) (which may hereinafter be abbreviated as “Me-AZADO cation”): 1-methyl-2-azaadamantan-2-ol (another name: 1-methyl-2-azatricyclo[3.3.1.13,7]decan-2-ol) (which may hereinafter be abbreviated as “Me-AZADOH): 5-hydroxy-1-methyl-2-azaadamantane-N-oxyl (another name: (5-hydroxy-1-methyl-2-azatricyclo[3.3.1.13,7]dec-2-yl)oxidanyl) (which may hereinafter be abbreviated as “5-OH-1-Me-AZADO”: 5-hydroxy-1-methyl-2-azaadamantane-N-oxoammonium cation (another name: 5-hydroxy-1-methyl-2-oxo-2-azoniatricyclo[3.3.1.13,7]decane) (which may hereinafter abbreviated as “5-OH-1-Me-AZADO cation”): 5-hydroxy-1-methyl-2-azaadamantan-2-ol (another name: 1-methyl-2-azatricyclo[3.3.1.13,7]decane-2,5-diol) (which may hereinafter be abbreviated as “5-OH-1-Me-AZADOH”): 5-methoxy-1-methyl-2-azaadamantane-N-oxyl (another name: (5-methoxy-1-methyl-2-azatricyclo[3.3.1.13,7]dec-2-yl)oxidanyl) (which may hereinafter be abbreviated as “5-MeO-1-Me-AZADO”): 5-methoxy-1-methyl-2-azaadamantane-N-oxoammonium cation (another name: (5-methoxy-1-methyl-2-oxo-2-azoniatricyclo[3.3.1.13,7]decane) (which may hereinafter be abbreviated as “5-MeO-1-Me-AZADO cation”): 5-methoxy-1-methyl-2-azaadamantan-2-ol (another name: (5-methoxy-1-methyl-2-azatricyclo[3.3.1.13,7]decan-2-ol) (which may hereinafter be abbreviated as “5-MeO-1-Me-AZADOH”): 5-fluoro-1-methyl-2-azaadamantane-N-oxyl (another name: (5-fluoro-1-methyl-2-azatricyclo[3.3.1.13,7]dec-2-yl)oxidanyl) (which may hereinafter be abbreviated as “5-F-1-Me-AZADO”): 5-fluoro-1-methyl-2-azaadamantane-N-oxoammonium cation (another name: (5-fluoro-1-methyl-2-oxo-2-azoniatricyclo[3.3.1.13,7]decane) (which may hereinafter be abbreviated as “5-F-1-Me-AZADO cation): 5-fluoro-1-methyl-2-azaadamantan-2-ol (another name: 5-fluoro-1-methyl-2-azatricyclo[3.3.1.13,7]decan-2-ol) (which may hereinafter be abbreviated as “5-F-1-Me-AZADOH”): 1-fluoro-2-azaadamantane-N-oxyl (another name: (1-fluoro-2-azatricyclo[3.3.1.13,7]dec-2-yl)oxidanyl) (which may hereinafter be abbreviated as “1-F-AZADO”): 1-fluoro-2-azaadamantane-N-oxoammonium cation (another name: 1-fluoro-2-oxo-azoniatricyclo[3.3.1.13′]decane) (which may hereinafter be abbreviated as “1-F-AZADO cation”): 1-fluoro-2-azaadamantan-2-ol (another name: 1-fluoro-2-azatricyclo[3.3.1.13,7]decan-2-ol) (which may hereinafter be abbreviated as “1-F-AZADOH”): 5-fluoro-2-azaadamantane-N-oxyl (another name: (5-fluoro-2-azatricyclo[3.3.1.13,7]dec-2-yl)oxidanyl) (which may hereinafter be abbreviated as “5-F-AZADO”): 5-fluoro-2-azaadamantane-N-oxoammonium cation (another name: 5-fluoro-2-oxo-azoniatricyclo[3.3.1.13,7]decane) (which may hereinafter be abbreviated as “5-F-AZADO cation”): 5-fluoro-2-azaadamantan-2-ol (another name: 5-fluoro-2-azatricyclo[3.3.1.13,7]decan-2-ol) (which may hereinafter be abbreviated as “5-F-AZADOH”): 5,7-difluoro-1-methyl-2-azaadamantane-N-oxyl (another name: (5,7-difluoro-1-methyl-2-azatricyclo[3.3.1.13,7]dec-2-yl)oxidanyl) (which may hereinafter be abbreviated as “5,7-diF-1-Me-AZADO”) 5,7-difluoro-1-methyl-2-azaadamantane-N-oxoammonium cation (another name: (5,7-difluoro-1-methyl-2-oxo-2-azoniatricyclo[3.3.1.13,7]decane) (which may hereinafter be abbreviated as “5,7-diF-1-Me-AZADO cation”): 5,7-difluoro-1-methyl-2-azaadamantan-2-ol (another name: 5,7-difluoro-1-methyl-2-azatricyclo[3.3.1.13,7]decan-2-ol) (which may hereinafter be abbreviated as “5,7-diF-1-Me-AZADOH): 1,3-dimethyl-2-azaadamantane-N-oxyl (another name: (1,3-dimethyl-2-azatricyclo[3.3.1.13,7]dec-2-yl)oxidanyl) (which may hereinafter be abbreviated as “1,3-diMe-AZADO”): 1,3-dimethyl-2-azaadamantane-N-oxoammonium cation (another name: 1,3-dimethyl-2-oxo-2-azoniatricyclo[3.3.1.13,7]decane) (which may hereinafter be abbreviated as “1,3-diMe-AZADO cation): and 1,3-dimethyl-2-azaadamantan-2-ol (another name: 1,3-dimethyl-2-azatricyclo[3.3.1.13,7]decan-2-ol) (which may hereinafter be abbreviated as “1,3-diMe-AZADOH”): In the present invention, the compound represented by the formula (I-2) include 9-aza-noradamantane-N-oxyl (another name: octahydro-2,5-epimino-pentalen-7-yloxidanyl) (which may hereinafter be abbreviated as “Nor-AZADO”): 9-aza-noradamantane-N-oxoammonium cation (another name: 7-oxooctahydro-2,5-epiminopentalenium) (which may hereinafter be abbreviated as “Nor-AZADO cation”): and 9-aza-noradamantan-9-ol (another name: octahydro-2,5-epimino-pentalen-7-ol) (which may hereinafter be abbreviated as “Nor-AZADOH”): In the present invention, the compound represented by the formula (I-3) include 9-azabicyclo-[3.3.1]nonane-N-oxyl (another name: 9-azabicyclo[3.3.1]non-9-yloxidanyl) (which may hereinafter be abbreviated as “ABNO”): 9-azabicyclo-[3.3.1]nonane-N-oxoammonium cation (another name: 9-oxo-9-azoniabicyclo[3.3.1]nonane) (which may hereinafter be abbreviated as “ABNO cation”): and 9-azabicyclo-[3.3.1]nonan-9-ol (another name: 9-azabicyclo[3.3.1]nonan-9-ol) (which may hereinafter be abbreviated as “ABNOH”): In the present invention, “2,2,6,6-tetramethylpiperidine-N-oxyl” is a compound having a structure represented by the following formula: In the present invention, “2,2,6,6-tetramethylpiperidin-1-ol” is a compound having a structure represented by the following formula: In the present invention, “4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl” is a compound having a structure represented by the following formula: In the present invention, “2,2,6,6-tetramethyl-1,4-piperidinediol” is a compound having a structure represented by the following formula: In the present invention, the term “AZADO analogs” means compounds represented by the formula (I-1), (I-2), and (I-3), salts thereof, and solvates thereof.", "In the present invention, the term “oxidation catalyst” means an N-oxyl oxidation catalyst and examples include the above-mentioned AZADO analogs and 2,2,6,6-tetramethylpiperidine-N-oxyl, 2,2,6,6-tetramethylpiperidin-1-ol, 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl, and 2,2,6,6-tetramethyl-1,4-piperidinediol, salts thereof, and solvents thereof.", "These oxidation catalysts are reagents to be used in an oxidation reaction for synthesizing a ketone compound from an alcohol compound.", "In the present invention, the term “weight ratio” means a proportion (ratio) of the weight of a certain substance relative to the weight of a standard substance.", "For example, the phrase “in the presence of an ammonium ion in a weight ratio of 170 ppm or less relative to Compound (EM)” means that “in the presence of an ammonium ion in an amount of 170 μg or less per 1 g of Compound (EM)”.", "In the present invention, the term “molar ratio” means a proportion (percentage) of the number of moles of a certain substance relative to the number of moles of a standard substance.", "For example, the phrase “in the presence of an ammonium ion in a molar ratio of 145% or less relative to the oxidation catalyst” means that “in the presence of an ammonium ion in an amount of 1.45 mol or less per 1 mol of the oxidation catalyst”.", "In the present invention, the term “unpurified” means that Compound (EM), Compound (E) or Compound (E′) obtained by an organic reaction such as addition reaction has not been purified, more specifically, impurities (such as organic matters (for example, an organic compound (byproduct) other than the target compound, an organic compound which is a starting material that has remained after the reaction, and an organic reagent), inorganic matters (for example, sodium chloride, ammonium chloride, sodium hydroxide, and potassium hydroxide), and inorganic ions (for example, a cation such as sodium ion, potassium ion, lithium ion, and ammonium ion and an anion such as chloride ion and bromide ion) have not been removed by a conventional purification method, for example, distillation under reduced pressure, high-performance liquid chromatography using silica gel or magnesium silicate, thin-layer chromatography, ion exchange resin, scavenger resin, column chromatography, or recrystallization, or desalting treatment for not only removing organic matters which are impurities but also removing inorganic matters or inorganic ions.", "In the present invention, the term “conversion rate” means a percent of an original certain substance (raw material) which has been converted into another substance by a chemical reaction, based on the number of moles of the original certain substance (raw material).", "For example, the phrase “a preparation process that has provided a conversion rate of 98%” means “a preparation process in which 98% of a substance used as a raw material has been converted into another substance on the basis of the number of moles”, in other words, “a preparation process in which 2% of a substance used as a raw material has remained on the basis of the number of moles”.", "In the present invention, the term “phosphate buffer” means a solution obtained by mixing an aqueous solution of sodium dihydrogen phosphate and an aqueous solution of sodium monohydrogen phosphate at any ratio and the mixed solution has a pH of from about 5.8 to 8.0.In the present invention, examples of the “oxidizing agent” include sodium hypochlorite (NaOCl), sodium chlorite (NaClO2), sodium bromite (NaBrO2), calcium hypochlorite (Ca(OCl)2), Oxone (trade mark), metachloroperbenzoic acid (MCPBA), iodosylbenzene (PhI═O), iodobenzene diacetate (PhI(OAc)2), orthoperiodic acid (H5IO6), potassium ferricyanide (K3[Fe(CN)6]), and N-chlorosuccinic acid imide (NCS).", "In the present invention, the “solvent” in “the reaction composition containing a compound selected from the group consisting of 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester, 3-[(S)-7-bromo-2-((R)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester, and 3-[(S)-7-bromo-2-((S)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester, an oxidizing agent, an oxidation catalyst, and a solvent”, that is, the “solvent” to be used in the oxidation reaction is an organic solvent (for example, ethyl acetate, methyl acetate, toluene, methylene chloride, dichloroethane, acetonitrile, dimethylsulfoxide, or acetone, or a solvent obtained by mixing these organic solvents as needed) or a mixed solvent of the above-mentioned organic solvent and water.", "In the present invention, the term “reaction composition” means an assembly of organic matters and inorganic matters present in the reaction system of a chemical reaction.", "For example, in an oxidation reaction, the reaction composition of the oxidation reaction contains a starting material, a reaction reagent (such as oxidizing agent), a reaction catalyst (such as oxidation catalyst), and a solvent and it may further contain an inorganic salt (such as ammonium chloride, ammonium bromide, ammonium acetate, ammonium carbonate, sodium monohydrogen phosphate, and sodium dihydrogen phosphate), and an inorganic ion (such as ammonium ion, chloride ion, bromide ion, acetate ion, carbonate ion, phosphate ion, and sodium ion).", "In the present invention, R1 is preferably hydrogen, fluorine, or methyl, more preferably hydrogen or methyl, particularly preferably hydrogen.", "In the present invention, R2 is preferably hydrogen, fluorine, a hydroxyl group, or methoxy, more preferably hydrogen.", "In the present invention, R3 is preferably hydrogen or fluorine, more preferably hydrogen.", "In the present invention, R5 is preferably hydrogen or methyl, more preferably hydrogen.", "In the present invention, X is preferably nitrogen (N) or an ammonium cation (N′), more preferably nitrogen.", "In the present invention, R4 is preferably an oxygen radical (O′), a hydroxyl group (OH), or oxygen (O), more preferably an oxygen radical or a hydroxyl group, particularly preferably a hydroxyl group.", "In the present invention, is a single bond or a double bond, preferably a single bond.", "In the present invention, is preferably N—O* or N—OH, more preferably N—OH.", "In the intention, the compound represented by the formula (I-1) is preferably AZADO, AZADO cation, AZADOH, Me-AZADO, Me-AZADO cation, Me-AZADOH, 5-OH-1-Me-AZADO, 5-OH-1-Me-AZADO cation, 5-OH-1-Me-AZADOH, 5-MeO-1-Me-AZADO, 5-MeO-1-Me-AZADO cation, 5-MeO-1-Me-AZADOH, 5-F-1-Me-AZADO, 5-F-1-Me-AZADO cation, 5-F-1-Me-AZADOH, 1-F-AZADO, 1-F-AZADO cation, 1-F-AZADOH, 5-F-AZADO, 5-F-AZADO cation, 5-F-AZADOH, 5,7-diF-1-Me-AZADO, 5,7-diF-1-Me-AZADO cation, 5,7-diF-1-Me-AZADOH, 1,3-diMe-AZADO, 1,3-diMe-AZADO cation, or 1,3-diMe-AZADOH, more preferably AZADO, AZADO cation, AZADOH, Me-AZADO, Me-AZADO cation, or Me-AZADOH, still more preferably AZADO, AZADO cation, or AZADOH, still more preferably AZADO or AZADOH, particularly preferably AZADOH.", "In the present invention, the compound represented by the formula (I-2) is preferably Nor-AZADO, Nor-AZADO cation, or Nor-AZADOH, more preferably Nor-AZADO.", "In the present invention, the compound represented by the formula (I-3) is preferably ABNO, ABNO cation, or ABNOH, more preferably ABNO.", "In the present invention, the oxidation catalyst is preferably AZADO, AZADO cation, AZADOH, Me-AZADO, Me-AZADO cation, Me-AZADOH, 5-OH-1-Me-AZADO, 5-OH-1-Me-AZADO cation, 5-OH-1-Me-AZADOH, 5-MeO-1-Me-AZADO, 5-MeO-1-Me-AZADO cation, 5-MeO-1-Me-AZADOH, 5-F-1-Me-AZADO, 5-F-1-Me-AZADO cation, 5-F-1-Me-AZADOH, 1-F-AZADO, 1-F-AZADO cation, 1-F-AZADOH, 5-F-AZADO, 5-F-AZADO cation, 5-F-AZADOH, 5,7-diF-1-Me-AZADO, 5,7-diF-1-Me-AZADO cation, 5,7-diF-1-Me-AZADOH, 1,3-diMe-AZADO, 1,3-diMe-AZADO cation, 1,3-diMe-AZADOH, Nor-AZADO, Nor-AZADO cation, Nor-AZADOH, ABNO, ABNO cation, or ABNOH, more preferably AZADO, AZADO cation, AZADOH, Me-AZADO, Me-AZADO cation, Me-AZADOH, Nor-AZADO, or ABNO, still more preferably AZADO, AZADO cation, or AZADOH, still more preferably AZADO or AZADOH, particularly preferably AZADOH.", "In the present invention, the conversion rate is preferably 98% or more, more preferably 98.5% or more, still more preferably 99% or more, still more preferably 99.5% or more, particularly preferably 100%.", "In the present invention, in order to attain the conversion rate falling within the above-mentioned preferred range, it is recommended, in the reaction system of the oxidation reaction, to adjust the weight ratio of an ammonium ion, relative to each of Compound (EM), Compound (E), and Compound (E′), to a predetermined level or less; to adjust the molar ratio of an ammonium ion relative to the oxidation catalyst to a predetermined level or less; or to satisfy both.", "The weight ratio of an ammonium ion relative to each of Compound (EM), Compound (E), and Compound (E′) is at least about 170 ppm or less, preferably about 111 ppm or less, more preferably about 91 ppm or less, still more preferably about 72 ppm or less, still more preferably about 53 ppm or less, particularly preferably about 33 ppm or less.", "The molar ratio of an ammonium ion relative to the oxidation catalyst is at least about 145% or less, preferably about 94% or less, more preferably about 78% or less, still more preferably about 61% or less, still more preferably about 45% or less, particularly preferably about 28% or less.", "Compound (FK) can be obtained from each of Compound (EM), Compound (E), and Compound (E′) at the above-mentioned preferable conversion rate by adjusting the weight ratio of an ammonium ion relative to each of Compound (EM), Compound (E), and Compound (E′) to fall within the above-mentioned range, by adjusting the molar ratio of an ammonium ion relative to the oxidation catalyst to fall within the above-mentioned range, or by satisfying both.", "In the present invention, Compound (EM) to be used in the oxidation reaction is preferably obtained by conducting an addition reaction between Compound (D) and 1-aminopropan-2-ol and then washing.", "In the present invention, Compound (E) to be used in the oxidation reaction is preferably obtained by conducting an addition reaction between Compound (D) and (R)-1-aminopropan-2-ol and then washing.", "In the present invention, Compound (E′) to be used in the oxidation reaction is preferably obtained by conducting an addition reaction between Compound (D) and (S)-1-aminopropan-2-ol or and then washing.", "In the present invention, the term “washing” in the phrase “obtained by conducting an addition reaction between Compound (D) and 1-aminopropan-2-ol, (R)-1-aminopropan-2-ol, or (S)-1-aminopropan-2-ol and then washing” means a work-up operation, which is to be conducted after the addition reaction, with a solution having a pH near a weakly acidic to weakly basic range (from about pH 3.5 to about pH 10.5, preferably from about pH 4.5 to about pH 9.0), particularly preferably a pH near a weakly acidic to neutral range (from about pH 5.5 to about pH 8.0) and having a buffer action.", "The solution used for washing is a water soluble solution and examples include an aqueous solution of ammonium chloride (from about pH 4.5 to pH 6.0), an aqueous solution of sodium monohydrogen phosphate (about pH 9.5), an aqueous solution of sodium dihydrogen phosphate (from about pH 3.8 to about pH 4.5), a phosphate buffer (from about pH 5.8 to about pH 8.0), a potassium phosphate buffer (about pH 10.0), a phosphate buffer saline (about pH 7.4), an acetate buffer (acetic acid+sodium acetate; from about pH 3.6 to pH 5.6), a citrate buffer (citric acid+sodium citrate; from about pH 3.0 to about pH 6.2), a citrate-phosphate buffer (from about pH 2.6 to about pH 7.0), a borate buffer (from about pH 8.0 to about pH 10.3), and a tartrate buffer (from about pH 2.9 to about pH 4.2).", "In the present invention, a washing method is preferably a method of washing with an aqueous solution of ammonium chloride, an aqueous solution of sodium dihydrogen phosphate, an aqueous solution of sodium monohydrogen phosphate, or a phosphate buffer (a mixed solution obtained by mixing an aqueous solution of sodium dihydrogen phosphate and an aqueous solution of sodium monohydrogen phosphate at any ratio); more preferably a method of washing with an aqueous solution of sodium dihydrogen phosphate, an aqueous solution of sodium monohydrogen phosphate, or a phosphate buffer; still more preferably, a method of washing with an aqueous solution of sodium dihydrogen phosphate or a phosphate buffer; particularly preferably a method of washing with a phosphate buffer.", "In the present invention, as is apparent for those skilled in the art, the symbol: represents bonding to the opposite side of the paper plane (that is, α-configuration); the symbol: represents bonding to the near side of the paper plane (that is, β-configuration); the symbol: represents α-configuration or β-configuration; and the symbol: represents a mixture of the α-configuration and the β-configuration at any ratio, unless otherwise noted.", "[Salt] The compound represented by the formula (I-1), (I-2), or (I-3), 2,2,6,6-tetramethylpiperidine-N-oxyl, 2,2,6,6-tetramethylpiperidin-1-ol, 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl, or 2,2,6,6-tetramethyl-1,4-piperidinediol is converted into a salt thereof by a known method.", "The salt is preferably a pharmaceutically acceptable salt.", "The salt is preferably water soluble.", "Examples of the salt include acid addition salts.", "Examples of the acid addition salts include inorganic acid salts such as hydrochloride, hydrobromide, hydroiodide, sulfate, phosphate, nitrate, borate, tetrafluoroborate, perchlorate, antimonate, and hexafluorophosphate and organic acid salts such as acetate, lactate, tartrate, benzoate, citrate, methanesulfonate, ethanesulfonate, trifluoroacetate, benzenesulfonate, toluenesulfonate, isethionate, glucuronate, and gluconate.", "In the present invention, the acid addition salt is preferably an inorganic acid salt or an acetate, more preferably, a hydrochloride, a hydrobromide, a hydroiodide, a sulfate, a phosphate, a nitrate, a borate, a tetrafluoroborate, a perchlorate, an antimonate, a hexafluorophosphate, or an acetate, particularly preferably a hydrochloride, a nitrate, a tetrafluoroborate, or an acetate.", "[Solvate] The compound represented by the formula (I-1), (I-2), or (I-3), 2,2,6,6-tetramethylpiperidine-N-oxyl, 2,2,6,6-tetramethylpiperidin-1-ol, 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl, or 2,2,6,6-tetramethyl-1,4-piperidinediol, or a salt thereof is converted into a solvate thereof by a known method.", "The solvate is preferably nontoxic and water soluble.", "Examples of the suitable solvate include solvates with water or an alcoholic solvent (for example, ethanol).", "Atoms each constituting Compound (D), Compound (EM), Compound (E), Compound (E′), Compound (FK), Compound (P), the formula (I-1), the formula (I-2), and the formula (I-3) may be substituted by an isotope thereof (for example, 2H, 3H, 13C, 14C, 15N, 16I, 17O, or 18O).", "The preparation process according to the present invention will next be described.", "First, a process for preparing Compound (FK) from Compound (EM) according to the present invention is shown by the following reaction scheme 1.Compound (EM) can be prepared readily by a known method, for example, a method shown below in the reaction scheme 2, a method based thereon, the method described in “Comprehensive Organic Transformations: A Guide to Functional Group Preparations 2nd Edition (Richard C. Larock, John Wiley & Sons Inc, 1999)”, or the method described in WO 2000/069836.Incidentally, Compound (EM) may be used as a salt thereof.", "As such a salt, a pharmaceutically acceptable salt, for example, an acid addition salt may be used.", "As the acid addition salt, for example, those described as an acid addition salt in the above column [salt] may be used.", "Compound (EM) or salt thereof used in the reaction scheme 1 may be used as a solvate thereof.", "Examples of the solvate include solvates with water or with an alcoholic solvent (for example, ethanol).", "In the oxidation reaction for preparing Compound (FK) from Compound (EM) described in the reaction scheme 1, using an unpurified Compound (EM) is novel.", "In addition, using an AZADO analog as an oxidation catalyst to be used in the oxidation reaction for preparing Compound (FK) from Compound (EM) is novel.", "Compound (FK) available by this reaction can be prepared, for example, by reacting Compound (EM) which may be unpurified at a temperature of from about −20° C. to 50° C. in an organic solvent (for example, ethyl acetate, methyl acetate, toluene, methylene chloride, dichloroethane, acetonitrile, dimethylsulfoxide, or acetone, or a solvent obtained by mixing the above-mentioned organic solvents as needed) or a mixed solvent of such an organic solvent and water, in the presence or absence of a base (for example, sodium hydrogen carbonate, sodium carbonate, 1,4-diazabicyclo[2.2.2]octane, or potassium hydroxide, or a base obtained by mixing the above-mentioned bases as needed) or an aqueous solution of such a base, in the presence or absence of an inorganic salt (for example, sodium bromide, potassium bromide, potassium chloride, copper chloride, copper bromide, butylammonium bromide, butylammonium chloride, sodium nitrite, or sodium acetate, or an inorganic salt obtained by mixing these inorganic salts as needed), and in the presence of an oxidizing agent (for example, sodium hypochlorite (NaOCl), sodium chlorite (NaClO2), sodium hypobromite (NaBrO2), calcium hypochlorite (Ca(OCl)2), Oxone (trade mark), metachloroperbenzoic acid (MCPBA), iodosylbenzene (PhI═O), iodobenzene diacetate (PhI(OAc)2), orthoperiodic acid (H5IO6), potassium ferricyanide (K3[Fe(CN)6]), or N-chlorosuccinic acid imide (NCS), or an oxidizing agent obtained by mixing the above-mentioned oxidizing agents as needed) and the above-mentioned oxidation catalyst (for example, AZADO analogs (for example, AZADO, Me-AZADO, AZADOH, Nor-AZADO, or ABNO, or an oxidation catalyst obtained by mixing the above-mentioned oxidation catalysts as needed)).", "As another process, Compound (FK) can be prepared, for example, by subjecting Compound (EM) which may be unpurified to an air (oxygen) oxidation reaction at a temperature of from about 0° C. to 80° C. in an organic solvent (for example, ethyl acetate, toluene, methylene chloride, dichloroethane, acetonitrile, dimethylsulfoxide, acetone, or acetic acid, or a solvent obtained by mixing the above-mentioned organic solvents as needed) or a mixed solvent of such an organic solvent and water, in the presence or absence of a base (for example, sodium hydrogen carbonate, sodium carbonate, 1,4-diazabicyclo[2.2.2] octane, or potassium hydroxide, or a base obtained by mixing these bases as needed) or an aqueous solution of such a base, in the presence or absence of an inorganic salt (for example, sodium bromide, potassium bromide, potassium chloride, copper chloride, copper bromide, butylammonium bromide, or butylammonium chloride, or an inorganic salt obtained by mixing the above-mentioned inorganic salts as needed), in the presence of the above-mentioned oxidation catalyst (for example, AZADO analogs (for example, AZADO, Me-AZADO, AZADOH, Nor-AZADO, or ABNO, or an oxidation catalyst obtained by mixing the above-mentioned oxidation catalysts as needed).", "As a further process, Compound (FK) can be prepared by subjecting, instead of Compound (EM), Compound (E) or Compound (E′) to the above-mentioned oxidation reaction.", "The compound subjected to the oxidation reaction in the present invention is preferably Compound (E) or Compound (E′), more preferably Compound (E).", "Compound (EM) can be prepared, for example, by the process shown in the following reaction scheme 2.The reaction for preparing Compound (EM) from Compound (D) in the reaction scheme 2 is a known one.", "A work-up method in the reaction scheme 2 for preparing Compound (FK) at a markedly high conversion rate (reaction efficiency) is however utterly unknown when Compound (EM) obtained by the above reaction, particularly when it is an unpurified compound, is subjected to the oxidation reaction (in the above reaction scheme 1) in the next step.", "Compound (EM) can be prepared, for example, by using Compound (D), adding thereto 1-aminopropan-2-ol, and reacting the resulting mixture at a temperature of from about −80° C. to 50° C. in an organic solvent (for example, tetrahydrofuran (THF), diethyl ether, tert-butyl methyl ether (t-BuOMe), dioxane, hexamethylphosphoric acid triamide (HMPA), acetonitrile, toluene, ethylbenzene, diglyme, heptane, hexane, or cyclohexane, or a solvent obtained by mixing the above-mentioned organic solvents as needed), in the presence of a base (for example, lithium diisopropylamide (LDA), lithium bis(trimethylsilyl)amide (LiN(TMS)2), sodium bis(trimethylsilyl)amide (NaN(TMS)2), potassium bis(trimethylsilyl)amide (KN(TMS)2), n-butyl lithium, sec-butyl lithium, or tert-butyl lithium, or a base obtained by mixing the above-mentioned bases as needed), in the presence or absence of an inorganic salt (for example, lithium chloride, lithium bromide, zinc chloride, or palladium diacetate (Pd(OAc)2), or an inorganic salt obtained by mixing the above-mentioned inorganic salts as needed), in the presence of an activating reagent (for example, trifluoromethanesulfonic anhydride ((CF3SO2)2O), diethyl chlorophosphate ((EtO)2P(O)Cl), trichlorosilane (TMSCl), phosphoryl chloride (P(O)Cl3), or bismorpholinophosphoryl chloridate (BMPC): or a reagent obtained by mixing the above-mentioned activating reagents as needed).", "The work-up method to be conducted after the reaction for preparing Compound (EM) from Compound (D) in the reaction scheme 2 can be positioned as one of the characteristics of the present invention.", "The work-up method is preferably conducted in a water soluble solution near a pH range from weakly acidic to weakly alkaline (from about pH 3.5 to about pH 10.5).", "The water soluble solution is more preferably near a pH range from weakly acidic to weakly alkaline (from about pH 4.5 to about 9.0), particularly preferably near a pH range from weakly acidic to neutral (from about pH 5.5 to about 8.0).", "Such a work-up method can be classified roughly into two methods: that is, a method including a step of quenching with an ammonium ion-containing solution and a method including a step of quenching with an ammonium ion-free solution.", "The method including a step of quenching with an ammonium ion-containing solution can be conducted by adding an aqueous solution of ammonium chloride in a reaction vessel in which the reaction for preparing Compound (EM) from Compound (D) has been conducted by the above-mentioned process to quench and then conducting sufficient water washing of the organic layer obtained by a separation operation.", "It can also be conducted by adding, to an aqueous solution of ammonium chloride, the reaction mixture obtained by the reaction for preparing Compound (EM) from Compound (D), to quench and then subjecting the resulting mixture to sufficient water washing.", "The term “sufficient water washing” as used herein means continuing water washing until the remaining content of an ammonium ion in the organic layer decreases to at least about 170 ppm or less, preferably about 111 ppm or less, more preferably about 91 ppm or less, still more preferably about 72 ppm or less, still more preferably about 53 ppm or less, particularly preferably about 33 ppm or less, relative to Compound (EM); continuing water washing until the molar ratio of an ammonium ion in the organic layer decreases to at least about 145% or less, preferably about 94% or less, more preferably about 78% or less, more preferably about 61% or less, still more preferably 45% or less, particularly preferably about 28% or less, relative to an oxidation catalyst used for the oxidation reaction of Compound (EM); or continuing water washing until both of the above-mentioned conditions are satisfied.", "The method including a step of quenching with an ammonium ion-free solution can be conducted by adding, to a reaction vessel in which the reaction for preparing Compound (EM) from Compound (D) has been conducted, an aqueous solution of sodium dihydrogen phosphate, an aqueous solution of sodium monohydrogen phosphate, a phosphate buffer, a potassium phosphate buffer, a phosphate buffer saline, an acetate buffer (acetic acid+sodium acetate), a citrate buffer (citric acid+sodium citrate), a citrate-phosphate buffer, a borate buffer, or a tartrate buffer to quench and then conducting water washing of the organic layer obtained by a separation operation.", "It can also be conducted by adding the reaction mixture obtained by the reaction for preparing Compound (EM) from Compound (D) to an aqueous solution of sodium dihydrogen phosphate, an aqueous solution of sodium monohydrogen phosphate, a phosphate buffer, a potassium phosphate buffer, a phosphate buffer saline, an acetate buffer (acetic acid+sodium acetate), a citrate buffer (citric acid+sodium citrate), a citrate-phosphate buffer, a borate buffer, or a tartrate buffer to quench and then conducting water washing of the organic layer as described above.", "Different from the water washing conducted when the above-mentioned aqueous solution of ammonium chloride is used, no particular limitation is imposed on the water washing in this operation and water washing at only once is sufficient.", "The solution to be used in such a step of quenching with an ammonium ion-free solution is preferably an aqueous solution of sodium dihydrogen phosphate, an aqueous solution of sodium monohydrogen phosphate, and/or a phosphate buffer, more preferably an aqueous solution of sodium dihydrogen phosphate and/or a phosphate buffer, particularly preferably a phosphate buffer.", "By conducting the work-up so as to create, in the reaction system of a subsequent oxidation reaction, a circumstance containing an ammonium ion as less as possible, the oxidation reaction from Compound (EM) to Compound (FK) can be conducted at a markedly high conversion rate (reaction efficiency) with good reproducibility.", "In the present invention, from the unpurified compound (EM) obtained by the above-mentioned work-up method, Compound (FK) can be prepared even without conducting purification such as distillation, silica gel chromatography, or recrystallization as described above, because the oxidation reaction proceeds at a markedly high conversion rate (reaction efficiency) with good reproducibility.", "In the present invention, Compound (E) obtained by using (R)-1-aminopropan-2-ol or Compound (E′) obtained by using (S)-1-aminopropan-2-ol can be obtained in a manner similar to that of the above-mentioned reaction scheme 2, instead of Compound (EM) obtained by using 1-aminopropan-2-ol in the reaction scheme 2.", "[Use for Pharmaceuticals] Compound (FK) in the present invention is an important synthesis intermediate of Compound (P) having sedative and anesthetic actions.", "Compound (P) is useful as a sedative or an anesthetic.", "This application claims priority to Japanese Patent Application No.", "2013-041492 filed on Mar.", "4, 2013, the entire contents of which are incorporated by reference herein.", "In this specification, all the contents of the patent documents, non-patent documents, and reference documents explicitly cited herein can be cited as a part of the specification.", "Examples The present invention will hereinafter be described by Examples, but it is not limited to or by them.", "The solvent in parentheses shown in the description of separation by chromatography or TLC is an eluting solvent or developing solvent used therefor and a ratio means a ratio by volume.", "The solvent in parentheses shown in the description of NMR is a solvent used in measurement.", "The compound name used herein is named using ACD/Name (trade mark) which is a computer program for naming generally based on the IUPAC rules or named according to IUPAC nomenclature.", "Example 1: Reaction from 3-[(S)-7-bromo-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propionic acid methyl ester (Compound (D)) to 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester (Compound (EM)) To Compound (D) (1.0 mmol) in 1.0 mL of tetrahydrofuran was added bismorpholinophosphoryl chloridate (BMPC) (1.2 mmol).", "At 0° C. or less, a tetrahydrofuran solution (1.8 M, 1.0 mmol, 0.56 mL) of lithium diisopropylamide was added dropwise to the reaction mixture.", "At 0° C., a solution of 1-aminopropan-2-ol (1.3 mmol) in 0.4 mL of tetrahydrofuran was added dropwise to the reaction mixture.", "The resulting reaction mixture was stirred overnight at 0° C. Example 2: Work-Up Method in Synthesis of Compound (EM) Example 2-1: Work-Up Method with Aqueous Solution of Ammonium Chloride To the reaction mixture of Example 1 were added about 16 mL of t-butyl methyl ether and about 10 mL of an aqueous solution of ammonium chloride (concentration: 25%) to separate it into layers.", "The organic layer thus obtained was washed with about 10 mL of an aqueous solution of ammonium chloride and then washed with water so as to decrease the weight ratio of an ammonium ion content in the organic layer to 170 ppm or less relative to Compound (EM).", "The organic layer thus obtained was concentrated to about 1.0 mL under reduced pressure.", "Toluene was added to the organic layer, followed by concentration under reduced pressure to about 1.0 mL.", "The toluene solution thus obtained was cooled to 0° C. The solid thus precipitated was collected by filtration and then dried to obtain Compound (EM) having the following physical properties.", "The measurement procedure of an ammonium ion content will be described later.", "TLC: Rf 0.35 (ethyl acetate); 1H-NMR (CDCl3): δ 8.70-8.60 (m, 1H), 7.88-7.82 (m, 1H), 7.81-7.75 (m, 1H), 7.53-7.47 (m, 1H), 7.40-7.33 (m, 2H), 7.15-7.10 (m, 1H), 5.71-5.65 (m, 1H), 5.20-4.70 (m, 1H), 4.15-3.95 (m, 1H), 3.71 (s, 3H), 3.48-3.38 (m, 1H), 3.33-3.14 (m, 1H), 3.30-3.20 (m, 1H), 2.85-2.73 (m, 1H), 2.66-2.35 (m, 3H), 1.20-1.18 (m, 3H).", "HPLC Conditions Column: YMC-Pack ODS-AQ (length: 25 cm, inner diameter: 4.6 mm, particle size: 3 μm, YMC) Column temperature: 25° C. Mobile phase: 10 mM aqueous potassium dihydrogen phosphate solution/acetonitrile=55/45 Flow rate: 0.7 mL/min Detector: UV 230 nm Injection amount: 5 μL Analysis time: 40 minutes The retention time under the above-mentioned conditions is 12.3 minutes and 12.8 minutes.", "Example 2-2: Work-Up Method with Sodium Dihydrogen Phosphate and/or Phosphate Buffer To the reaction mixture of Example 1 were added about 16 mL of t-butyl methyl ether and about 16 mL of an aqueous solution of sodium dihydrogen phosphate (concentration: 20%) to separate it into layers.", "The organic layer thus obtained was washed with about 10 mL of a phosphate buffer and then washed twice with water (about 5 mL).", "The organic layer thus obtained was concentrated to about 1.0 mL under reduced pressure.", "Toluene was added to the organic layer and the resulting mixture was concentrated to about 1.0 mL under reduced pressure.", "The toluene solution thus obtained was cooled to 0° C. The solid thus precipitated was collected by filtration and then dried to obtain Compound (EM) having the following physical properties.", "TLC: Rf 0.35 (ethyl acetate) 1H-NMR (CDCl3): δ 8.70-8.60 (m, 1H), 7.88-7.82 (m, 1H), 7.81-7.75 (m, 1H), 7.53-7.47 (m, 1H), 7.40-7.33 (m, 2H), 7.15-7.10 (m, 1H), 5.71-5.65 (m, 1H), 5.20-4.70 (m, 1H), 4.15-3.95 (m, 1H), 3.71 (s, 3H), 3.48-3.38 (m, 1H), 3.33-3.14 (m, 1H), 3.30-3.20 (m, 1H), 2.85-2.73 (m, 1H), 2.66-2.35 (m, 3H), 1.20-1.18 (m, 3H).", "HPLC Conditions Column: YMC-Pack ODS-AQ (length: 25 cm, inner diameter: 4.6 mm, particle size: 3 μm, YMC) Column temperature: 25° C. Mobile phase: 10 mM aqueous potassium dihydrogen phosphate solution/acetonitrile=55/45 Flow rate: 0.7 mL/min Detector: UV 230 nm Injection amount: 5 μL Analysis time: 40 minutes The retention time under the above-mentioned conditions is 12.3 minutes and 12.8 minutes.", "Example 3: Preparation of 3-[(S)-7-bromo-2-(2-oxo-propylamino)-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]propionic acid methyl ester (Compound (FK)) from 3-[(S)-7-bromo-2-(2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester (Compound (EM)) Example 3-1: Oxidation Reaction Using AZADO as Oxidation Catalyst To the unpurified compound (EM) (1.0 mmol) obtained in Example 1 and Example 2 in a mixed solvent of 3.4 mL of methyl acetate and 5.7 mL of toluene were added 0.46 mg of AZADO (0.003 mol), 1.9 mL of an aqueous solution of sodium hydrogen carbonate (7.7 wt %), and 6.0 mg of potassium bromide (0.05 mmol).", "At 0° C., 640 mg of an aqueous solution of sodium hypochlorite (14 wt %; 1.2 mmol) was added to the reaction mixture.", "The resulting mixture was stirred at 0° C. for one hour, followed by HPLC to find a conversion rate and confirm disappearance of the raw material.", "To the reaction mixture was added an aqueous solution of sodium thiosulfate to separate it into layers.", "The organic layer thus obtained was washed with an aqueous solution of ammonium chloride.", "The resulting organic layer was concentrated under reduced pressure.", "To the residue thus obtained were added toluene and methanol, followed by azeotropy to obtain Compound (FK) having the following physical properties.", "TLC: Rf 0.45 (ethyl acetate); HPLC Conditions Column: YMC-Pack ODS-AQ (length: 25 cm, inner diameter, 4.6 mm, particle size: 3 Gm, YMC) Column temperature: 25° C. Mobile phase: 10 mM aqueous potassium dihydrogen phosphate solution/acetonitrile=55/45 Flow rate: 0.7 mL/min Detector: UV 230 nm Injection amount: 5 μL Analysis time: 40 minutes The retention time under the above-mentioned conditions is 16.9 minutes.", "Example 3-2: Oxidation Reaction Using AZADOH as Oxidation Catalyst By an operation similar to that of Example 3-1 except for the use of 0.46 mg of AZADOH (0.003 mmol) instead of AZADO, Compound (FK) having the following physical properties was obtained.", "TLC: Rf 0.45 (ethyl acetate); HPLC Conditions Column: YMC-Pack ODS-AQ (length: 25 cm, inner diameter: 4.6 mm, particle size: 3 μm, YMC) Column temperature: 25° C. Mobile phase: 10 mM aqueous potassium dihydrogen phosphate solution/acetonitrile=55/45 Flow rate: 0.7 mL/min Detector: UV 230 nm Injection amount: 5 μL Analysis time: 40 minutes The retention time under the above-mentioned conditions is 16.9 minutes.", "Example 4: Synthesis of 3-[(S)-7-bromo-2-((R)-2-hydroxy-propylamino)-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl]propionic acid methyl ester (“Compound (E)”) By operations similar to those of Example 1 and Example 2 except for the use of (R)-1-aminopropan-2-ol instead of 1-aminopropan-2-ol, Compound (E) having the following physical properties was obtained.", "TLC: Rf 0.35 (ethyl acetate); 1H-NMR (CDCl3): δ 8.66 (ddd, J=4.9, 1.7, 0.9 Hz, 1H), 7.85 (d, J=7.6 Hz, 1H), 7.78 (td, J=7.6, 1.6 Hz, 1H), 7.50 (dd, J=8.8, 2.4 Hz, 1H), 7.38 (d, J=2.4 Hz, 1H), 7.40-7.33 (m, 1H), 7.12 (d, J=8.8 Hz, 1H), 5.69 (t, J=5.4 Hz, 1H), 5.17 (s, 1H), 4.06-3.93 (m, 1H), 3.71 (s, 3H), 3.48-3.38 (m, 1H), 3.33 (dd, J=10.0, 4.0 Hz, 1H), 3.26 (ddd, J=14.2, 6.4, 2.0 Hz, 1H), 2.85-2.73 (m, 1H), 2.66-2.35 (m, 3H), 1.17 (d, J=6.4 Hz, 3H).", "HPLC Conditions Column: YMC-Pack ODS-AQ (length: 25 cm, inner diameter: 4.6 mm, particle size: 3 μm, YMC) Column temperature: 25° C. Mobile phase: 10 mM aqueous potassium dihydrogen phosphate solution/acetonitrile=55/45 Flow rate: 0.7 mL/min Detector: UV 230 nm Injection amount: 5 μL Analysis time: 40 minutes The retention time under the above-mentioned conditions is 12.8 minutes.", "Example 5: Preparation of Compound (FK) from Compound (E) An operation similar to that of Example 3 (Example 3-1 or Example 3-2) was conducted using Compound (E) prepared in Example 4 to obtain Compound (FK) having the following physical properties.", "TLC: Rf 0.45 (ethyl acetate); HPLC Conditions Column: YMC-Pack ODS-AQ (length: 25 cm, inner diameter: 4.6 mm, particle size: 3 μm, YMC) Column temperature: 25° C. Mobile phase: 10 mM aqueous potassium dihydrogen phosphate solution/acetonitrile=55/45 Flow rate: 0.7 mL/min Detector: UV 230 nm Injection amount: 5 μL Analysis time: 40 minutes The retention time under the above-mentioned conditions is 16.9 minutes.", "Example 6: Preparation of Compound (P) from Compound (FK) To Compound (FK) prepared in Example 3 were added 32 mg of benzenesulfonic acid and 0.46 mL of methanol.", "The resulting mixture was stirred at 50° C. for five hours.", "After filtering the reaction mixture, 110 mg of benzenesulfonic acid and 0.2 mL of methanol were added to obtain Compound (P) TLC: Rf 0.42 (n-hexane/ethyl acetate=20/80) 1H-NMR (CDCl3): δ 16.0 (br s, 1H), 8.59 (d, J=4.2 Hz, 1H), 8.18 (d, J=8.4 Hz, 1H), 7.95-7.90 (m, 2H), 7.88-7.84 (m, 1H), 7.84 (dd, J=8.6, 2.2 Hz, 1H), 7.75 (d, J=2.2 Hz, 1H), 7.51-7.48 (m, 1H), 7.50 (d, J=8.6 Hz, 1H), 7.45-7.41 (m, 1H), 7.39-7.35 (m, 3H), 4.41 (dd, J=9.9, 3.9 Hz, 1H), 3.61 (s, 3H), 2.98-2.89 (m, 1H), 2.83-2.68 (m, 3H), 2.42 (s, 3H).", "HPLC Conditions Column: Cadenza CD-18 (length: 15 cm, inner diameter: 4.6 mm, particle size: 3 μm, Imtakt) Column temperature: 40° C. Mobile phase: A: 10 mM aqueous potassium dihydrogen phosphate solution, B: methanol A/B=from 50/50 (0 min) to 30/70 (50 minutes) Flow rate: 1.0 mL/min Detector: UV 230 nm Injection amount: 10 μL Analysis time: 50 minutes The retention time under the above-mentioned conditions is 20.7 minutes.", "Next, methods of measuring an ammonium ion content and calculating a conversion rate will be described, respectively.", "Test Method 1: Measurement of Ammonium Ion Content Standard solutions i to iv were analyzed using the analysis method shown below in a) and calibration curves were made.", "Sample solutions were analyzed and ammonium ion contents in Compound (EM), Compound (E), and Compound (E′) were determined, respectively, from the calibration curves.", "A preparation process b) of the standard solutions and a preparation process c) of the sample solutions are as described below.", "a) Ion Chromatograph Analysis Conditions Column: TSK-GEL IC-Cation (50×4.6 mm i.d.)", "Eluting solution: 2 mmol/L nitric acid Injection amount: 100 μL Flow rate: 1.2 mL/min Oven: 30° C. Polarity: − Response: 1.0 second b) Preparation of Standard Solutions After 100 mg of ammonium chloride was weighed, purified water was added thereto to make the whole volume 100 mL (standard solution i).", "After 1 mL of the resulting standard solution i was weighed, a mixed solution of methanol and water was added thereto to make the whole volume 100 mL (standard solution ii).", "After 10 mL of the resulting standard solution ii was weighed, a mixed solution of methanol and water was added thereto to make the whole volume 100 mL (standard solution iii).", "After 10 mL of the resulting standard solution iii was weighed, a mixed solution of methanol and water was added thereto to make the whole volume 100 mL (standard solution iv).", "c) Preparation of Sample Solutions After 20 mg of each of Compound (EM), Compound (E), and Compound (E′) was weighed, a mixed solution of methanol and water was added thereto to make the whole volume 20 ml.", "The resulting solution was used as a sample solution.", "Test Method 2: Calculation Method of Conversion Rate Conversion   Rate = A FK A FK + A ( EM ,  E ,  or   E ′ ) × 100 [ Equation   1 ] In the above equation, A represents a peak area of each compound in HPLC using the below-described method; AFK represents a peak area of Compound (FK); AEM represents a peak area of Compound (EM); AE represents a peak area of Compound (E); and AE represents a peak area of Compound (E′).", "HPLC Conditions Column: YMC-Pack ODS-AQ (length: 25 cm, inner diameter: 4.6 mm, particle size: 3 μm, YMC) Column temperature: 25° C. Mobile phase: 10 mM aqueous potassium dihydrogen phosphate solution/acetonitrile=55/45 Flow rate: 0.7 mL/min Detector: UV 230 nm Injection amount: 5 μL Analysis time: 40 minutes Example 7: Study on Reproducibility of Conversion Rate (Reaction Efficiency) The following experiment has revealed by using, for example, Compound (E) the reason why a reaction for preparing Compound (FK) from the unpurified Compound (EM), Compound (E), or Compound (E′) does not achieve a conversion rate (reaction efficiency) with reproducibility.", "Experiment of Cause Investigation 1: Addition of Expected Impurity into Compound (E) Experiment of Cause Investigation 1-1: Addition of Ammonium Chloride Ammonium chloride (2.0 mg, 0.038 mmol, weight ratio relative to Compound (E): 2000 ppm) was added to Compound (E) in a mixed solvent of 7.5 mL of methyl acetate, 12.5 mL of toluene, and 0.1 mL of water.", "At 0° C., 13 mg of potassium bromide (0.11 mmol), an aqueous solution of sodium hydrogen carbonate (4 mL, 7.7 wt %), and 0.99 mg of AZADO (0.0065 mmol) were added to the reaction mixture.", "At 0° C., 1.6 g of an aqueous solution of sodium hypochlorite (2.6 mmol, 12.3 wt %) was added to the reaction mixture.", "After stirring for one hour, a conversion rate of the reaction mixture was determined by the above-mentioned test method 2.Experiment of Cause Investigation 1-2: Addition of (R)-1-Aminopropan-2-Ol An operation similar to that of Experiment of cause investigation 1-1 except that ammonium chloride (2.0 mg) was replaced by the same weight of (R)-1-aminopropan-2-ol (2.0 mg) was conducted and a conversion rate was determined using the above-mentioned test method 2.Experiment of Cause Investigation 1-3: No Addition An operation similar to that of Experiment of cause investigation 1-1 was conducted without adding ammonium chloride instead of adding ammonium chloride (2.0 mg) and a conversion rate was determined using the above-mentioned test method 2.The results of the experiment of cause investigation 1 are shown below in Table 1.It has been found from Table 1 that when no ammonium chloride was added (Experiment of cause investigation 1-3) and when (R)-1-aminopropan-2-ol was added (Experiment of cause investigation 1-2), the oxidation reaction proceeded without a problem, a conversion rate was as high as 99.9%, and the reaction efficiency was good.", "When ammonium chloride was added (Experiment of cause investigation 1-1), on the other hand, the conversion rate of the oxidation reaction was 78.5% and the reaction efficiency was not quite satisfactory.", "TABLE 1 Conversion rate Experiment of cause of oxidation investigation 1 Addition or no addition of impurity reaction 1-1 Addition of ammonium chloride 78.5% 1-2 Addition of 99.9% (R)-1-aminopropan-2-ol 1-3 No addition 99.9% Experiment of Cause Investigation 2: Addition of Ammonium Chloride Analog into Experiment of Cause Investigation 2-1: Addition of Ammonium Chloride Ammonium chloride (2.0 mg, 0.038 mmol) was added to Compound (E) (1.0 g, 2.2 mmol) in a mixed solvent of 7.5 mL of methyl acetate, 12.5 mL of toluene, and 0.1 mL of water.", "At 0° C., 13 mg of potassium bromide (0.11 mmol), an aqueous solution of sodium hydrogen carbonate (4 mL, 7.7 wt %), and 0.99 mg of AZADO (0.0065 mmol) were added to the reaction mixture.", "At 0° C., 1.6 g of an aqueous solution of sodium hypochlorite (2.6 mmol, 12.3 wt %) was added to the reaction mixture.", "After stirring for one hour, a conversion rate of the reaction mixture was determined using the above-mentioned test method 2.Experiment of Cause Investigation 2-2: Addition of Ammonium Bromide An operation similar to that of Experiment of cause investigation 2-1 except that ammonium chloride (0.038 mmol) was replaced by the same molar amount of ammonium bromide (3.7 mg, 0.038 mmol) was conducted and a conversion rate was determined using the above-mentioned test method 2.Experiment of Cause Investigation 2-3: Addition of Ammonium Acetate An operation similar to that of Experiment of cause investigation 2-1 except that ammonium chloride (0.038 mmol) was replaced by the same molar amount of ammonium acetate (2.9 mg, 0.038 mmol) was conducted and a conversion rate was determined using the above-mentioned test method 2.Experiment of Cause Investigation 2-4: Addition of Ammonium Carbonate An operation similar to that of Experiment of cause investigation 2-1 except that ammonium chloride (0.038 mmol) was replaced with the same molar amount of ammonium carbonate (3.6 mg, 0.038 mmol) was conducted and a conversion rate was determined using the above-mentioned test method 2.Experiment of Cause Investigation 2-5: Addition of Aqueous Ammonia Solution An operation similar to that of Experiment of cause investigation 2-1 except that ammonium chloride (0.038 mmol) was replaced by the same molar amount of a 28 wt % aqueous ammonia solution (2.3 mL, 0.038 mmol) was conducted and a conversion rate was determined using the above-mentioned test method 2.Experiment of Cause Investigation 2-6: Addition of Sodium Chloride An operation similar to that of Experiment of cause investigation 2-1 except that ammonium chloride (0.038 mmol) was replaced by the same molar amount of sodium chloride (2.2 mg, 0.038 mmol) was conducted and a conversion rate was determined using the above-mentioned test method 2.Experiment of Cause Investigation 2-7: Addition of Hydrochloric Acid An operation similar to that of Experiment of cause investigation 2-1 except that ammonium chloride (0.038 mmol) was replaced by the same molar amount of 6 mol/L hydrochloric acid (0.0063 mL, 0.038 mmol) was conducted and a conversion rate was determined using the above-mentioned test method 2.Experiment of Cause Investigation 2-8: Addition of Tetrabutylammonium Bromide An operation similar to that of Experiment of cause investigation 2-1 except that ammonium chloride (0.038 mmol) was replaced by the same molar amount of tetrabutylammonium bromide (12.1 mg, 0.038 mmol) was conducted and a conversion rate was determined using the above-mentioned test method 2.The results of the experiment of cause investigation 2 are shown below in Table 2.It has been found from Table 2 that in Experiments of cause investigation 2-6 and 2-7, the oxidation reaction proceeded without a problem, the conversion rate was as high as about 99% or more, and the reaction efficiency was good, suggesting that the chloride ion of ammonium chloride is not a substance impeding the oxidation reaction.", "In Experiments of cause investigation 2-2, 2-3, 2-4, and 2-5, on the other hand, the conversion rate of the oxidation reaction was from about 30 to 60% and the reaction efficiency was much inferior, suggesting that the ammonium ion of ammonium chloride was presumed to be a substance impeding the oxidation reaction.", "In Experiment of cause investigation 2-8 in which a tetrabutylammonium ion, that is, the same cation as the ammonium ion was added, the oxidation reaction proceeded without a problem.", "From these findings, a substance impeding the efficient progress of the oxidation reaction was strongly presumed to be an ammonium ion.", "TABLE 2 Conversion rate Experiment of cause Addition of ammonium of oxidation investigation 2 chloride analog reaction 2-1 Ammonium chloride 78.5% 2-2 Ammonium bromide 37.3% 2-3 Ammonium acetate 29.9% 2-4 Ammonium carbonate 59.8% 2-5 Aqueous ammonia solution 55.8% 2-6 Sodium chloride 99.9% 2-7 Hydrochloric acid 98.9% 2-8 Tetrabutylammonium bromide 98.2% Based on the above-mentioned results of Experiments of cause investigation 1 and 2, Experiment 3 was conducted to find a correlation between an ammonium ion content and a conversion rate from Compound (E) to Compound (FK).", "Experiment 3: Experiment on Correlation Between Ammonium Ion Content and Conversion Rate Compound (FK) was prepared by an operation similar to that of Example 3 by using Compound (E) different in lot whose ammonium content had been determined using the above-mentioned test method 1, a conversion rate was calculated using the test method 2, and a correlation between an ammonium ion content and a conversion rate was found.", "The ammonium ion content and a conversion rate of each lot are as shown below in Table 3.Incidentally, for example, an ammonium ion content of 20 ppm in the Experiment 3-1 means that an ammonium ion content is 20 μg relative to 1 g of Compound (E).", "TABLE 3 Conversion rate Experiment Ammonium ion of oxidation 3 (Lot No.)", "content (ppm) reaction (%) 3-1 20 100 3-2 74 98.4 3-3 130 99.0 3-4 163 98.0 3-5 211 94.5 3-6 221 94.3 3-7 243 92.6 3-8 272 95.7 It has been found from the above results that when Compound (E) having an ammonium ion content of about 200 ppm or more is used as a raw material of an oxidation reaction, a conversion rate of the oxidation reaction varies and the oxidation reaction is not stable.", "It has also been found that when Compound (E) having an ammonium ion content of about 170 ppm or less is used as a raw material of an oxidation reaction, on the other hand, a conversion rate of the oxidation reaction is 98% or more and the oxidation reaction is stable with good reproducibility.", "FIG.", "1 shows these results as a graph.", "FIG.", "2 shows both the results of FIG.", "1 and an approximate curve (linear approximation).", "Although a negative relation can be found between an ammonium ion content and a conversion rate from Compound (E) to Compound (FK), it is preferred to understand that the approximate curve (linear approximation) shown in this graph is only one example because there are various ways how to find an approximate curve.", "The following was the equation of the approximate curve in the graph: [conversion rate (%)=−0.0258×(NH4+ content (ppm)+100.87)].", "INDUSTRIAL APPLICABILITY According to the present invention, Compound (FK) can be prepared at a markedly high conversion rate and/or oxidation catalyst efficiency with good reproducibility from a compound selected from the group consisting of Compound (EM), Compound (E), and Compound (E′), even if it is an unpurified compound.", "Compound (FK) is an important synthesis intermediate of Compound (P) having sedative and anesthetic actions.", "Since the preparation process of the present invention can stably supply Compound (FK) with good reproducibility without conducting a particular purification step, it is very useful from the standpoint of industrial productivity of Compound (P) which is an active pharmaceutical ingredient." ] ]
Patent_15875948
[ [ "Crash Event Detection, Response and Reporting Apparatus and Method", "A crash detection system with a mobile communications device configured for periodically interrogating (a) a motion signal to determine whether a change in motion (acceleration or angular rotation) exceeds a predetermined motion threshold and (b) a sound signal to determine whether a sequence of sensed sound signals within a predetermined period matches crash sound indicators of (i) glass breakage and (ii) metal folding, displaying selectable options upon detection of a crash incident, and upon a failure to select within a predetermined period, communicating an identifier and crash incident information dispatch center for dispatching a response servicer." ], [ "1.A system for detection of a crash of a motor vehicle with crash detection response and reporting, comprising: a mobile communications device configured with a sensor that generates a motion signal responsive to motion of the mobile communications device and a sound receiver for receiving a sound signal of sound proximate the mobile communications device, and including software instructions that upon execution monitors for an occurrence of a crash event by periodically interrogating (a) the motion signal to determine whether a change in motion exceeds a predetermined motion threshold and (b) the sound signal to determine whether a sequence of sensed sound signals within a predetermined period matches crash sound indicators of (i) glass breakage and (ii) metal folding; a display that upon determining the occurrence of the crash incident displays a possible event window with a selectable option (a) to return the mobile communications device to monitoring for the occurrence of the crash incident or (b) to confirm the crash incident; upon a failure of selection of one of the selectable options within a predetermined period, communicating by a communications network an identifier associated with the mobile communications device and crash incident information including a location data to a tracking and dispatch center having a pre-registered record of the mobile communications device and configured for receiving and storing the acceleration information and the sound signals on which the crash incident was determined; and a servicer for dispatching by the tracking and dispatch center to a site of the crash incident based on the location data.", "2.The system as recited in claim 1, further comprising a claims service center that receives from the tracking and dispatch center the identifier and crash incident information, the claims service center configured for servicing an insurance claim arising from the crash incident.", "3.The system as recited in claim 1, wherein the confirming of the crash incident comprises communicating crash incident location data to a response dispatch center.", "4.The system as recited in claim 3, further comprising a servicer for providing crash incident services in response to receiving the crash incident location data.", "5.The system as recited in claim 4, wherein the servicer comprises a transport vehicle for transporting a damaged motor vehicle at a site identified by the crash location data.", "6.The system as recited in claim 4, wherein the servicer comprises an insurance claims process service.", "7.The system as recited in claim 1, further comprising an electronic memory device configured for receiving and storing crash incident information.", "8.The system as recited in claim 1, wherein the sensor comprises an accelerometer that generates an acceleration signal as indicative of the motion of the mobile communications device.", "9.The system as recited in claim 1, wherein the sensor comprises a gyroscope that generates an angular rotation signal as indicative of the motion of the mobile communications device.", "10.A system for detecting a crash incident of a motor vehicle with crash detection response and reporting, comprising the steps of: (a) providing a mobile communications device having a sensor that generates an motion signal responsive to motion of the mobile communications device and a sound receiver for receiving a sound signal of sound proximate the mobile communications device, with software instructions configured for execution for monitoring for an occurrence of a crash event; (b) periodically interrogating (a) the motion signal to determine whether a change in motion exceeds a predetermined motion threshold and (b) the sound signal to determine whether a sequence of sensed sound signals within a predetermined period matches crash sound indicators of (i) glass breakage and (ii) metal folding; (c) based on interrogations of the motion signal and the sound signal, determining that crash incident occurred; (d) making an alert with the mobile communications device; (e) determining whether the alert generated a crash response through the mobile communications device, and if not, communicating a location data of the crash incident to a service provider for response; and (f) communicating a status of the service provider response to the mobile communications device.", "11.The system as recited in claim 10, wherein making the alert comprises the mobile communications device emitting a sound.", "12.The system as recited in claim 10, wherein making the alert comprises displaying on a screen of the mobile communications device a possible crash incident window that presents an instruction for making a response through the mobile communications device to confirm the detected crash incident or to deny the detected crash incident.", "13.A motor vehicle crash detection system, comprising: a tracking and dispatch center having a computer processor configured with an electronic memory device that maintains driver information of driver name, address, insurance company and policy number for a plurality of drivers and maintains vehicle crash information of motor vehicle, crash location data, date and time, and optionally one or more sequences of sounds from a crash location, one or more images thereof, for a plurality of crashed motor vehicles; a plurality of mobile communications devices, each associated with a respective one of the plurality of drivers and configured with a sensor that generates a motion signal responsive to motion of the mobile communications device and a sound receiver for receiving a sound signal of sound proximate the mobile communications device; the mobile communications device configured with software instructions that upon execution monitors for an occurrence of a crash event by periodically interrogating (a) the motion signal to determine whether a change in motion exceeds a predetermined motion threshold and (b) the sound signal to determine whether a sequence of sensed sound signals within a predetermined period matches crash sound indicators of (i) glass breakage and (ii) metal folding; a display that upon determining the occurrence of the crash incident displays a possible event window for selection of one of (a) to return the mobile communications device to monitoring for the occurrence of the crash incident and (b) to confirm the crash incident; upon a failure of selection of one of the selectable options within a predetermined period, the mobile communications device communicating by a communications network an identifier associated with the mobile communications device and crash incident information of a location data, date and time to the tracking and dispatch center; and at least one response servicer for dispatching by the tracking and dispatch center to a site of the crash incident based on the location data, the response servicer provides a lantern device having a light, an imaging device, and a communications device, whereby images received by the imaging device communicate by the communications device through the network to the tracking and dispatch center.", "14.The motor vehicle crash detection system as recited in claim 13, wherein the response servicer further provides a vehicle transporter, whereby the crashed motor vehicle may be transported from the crash location.", "15.The motor vehicle crash detection system as recited in claim 13, wherein the imaging device is operable for video.", "16.The motor vehicle crash detection system as recited in claim 13, wherein the imaging device is operable for single frame images.", "17.The motor vehicle crash detection system as recited in claim 13, further comprising an electronic data storage device installed for communication with the imaging device for recording of images prior to communicating the recorded images to the tracking and dispatch center.", "18.The motor vehicle crash detection system as recited in claim 13, further comprising a claims servicer for processing claims arising from the detected crash occurrence.", "19.The motor vehicle crash detection system as recited in claim 13, wherein the sensor comprises an accelerometer that generates an acceleration signal as indicative of the motion of the mobile communications device.", "20.The motor vehicle crash detection system as recited in claim 13, wherein the sensor comprises a gyroscope that generates an angular rotation signal as indicative of the motion of the mobile communications device." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>In recent years, improved roadways, traffic control devices, and safety devices that are installed and operated in motor vehicles have resulted in safer transportation by motor vehicle.", "Nevertheless, incidents and accidents involving car and truck motor vehicles continue to occur.", "These include vehicle-to-vehicle collisions as well as single vehicle accidents.", "While typically such incidents occur in locations where response personnel may be readily directed to provide medical and tow services, some incidents involving disappearance of the motor vehicle and its operation occur (such as a single vehicle accident in which the vehicle leaves the roadway and becomes hidden from view in woods or water).", "Also, monitoring services seek “how am I driving” reports typically for fleet operators to monitor driving activities of vehicle operators but parents having children as new or inexperienced drivers also have become interested in monitoring and reporting on motor vehicle operations.", "While systems having GPS location tracking features and cellular telecommunications devices have been installed in motor vehicles for communications between occupants and a tracking service provider, there are drawbacks to such systems.", "The operator may be injured or blocked from initiating communications.", "Also, the operator may be using a different vehicle such as a rental vehicle.", "Accordingly, there is a need in the art for an improved system and method for detecting occurrences of motor vehicle incidents, responding to detection of motor vehicle incident occurrences, and tracking and reporting on detection of and responses to motor vehicle incident occurrences.", "It is to such that the present invention is directed." ], [ "<SOH> BRIEF SUMMARY OF THE INVENTION <EOH>The present invention meets the needs in the art by providing a system for detection of a crash of a motor vehicle with crash detection response and reporting, comprising a mobile communications device configured with a sensor that generates a motion signal responsive to changes in motion of the mobile communications device and a sound receiver for receiving a sound signal of sound proximate the mobile communications device, and including software instructions that upon execution monitors for an occurrence of a crash event by periodically interrogating (a) the motion signal to determine whether a change in motion exceeds a predetermined motion threshold and (b) the sound signal to determine whether a sequence of sensed sound signals within a predetermined period matches crash sound indicators of (i) glass breakage and (ii) metal folding.", "A display that upon determining the occurrence of the crash incident displays a possible event window with a selectable option (a) to return the mobile communications device to monitoring for the occurrence of the crash incident or (b) to confirm the crash incident.", "Upon a failure of selection of one of the selectable options within a predetermined period, communicating by a communications network an identifier associated with the mobile communications device and crash incident information including a location data to a tracking and dispatch center having a pre-registered record of the mobile communications device and configured for receiving and storing the acceleration information and the sound signals on which the crash incident was determined.", "The tracking and dispatch center is configured to dispatch a servicer to a site of the crash incident based on the location data.", "In another aspect, the present invention provides a motor vehicle crash detection system, comprising a tracking and dispatch center having a computer processor configured with an electronic memory device that maintains driver information of driver name, address, insurance company and policy number for a plurality of drivers and maintains vehicle crash information of motor vehicle, crash location data, date and time, and optionally one or more sequences of sounds from a crash location, one or more images thereof, for a plurality of crashed motor vehicles.", "A plurality of mobile communications devices, each associated with a respective one of the plurality of drivers are each configured with a sensor that generates a motion signal responsive to changes in motion of the mobile communications device and a sound receiver for receiving a sound signal of sound proximate the mobile communications device.", "The mobile communications device configured with software instructions that upon execution monitors for an occurrence of a crash event by periodically interrogating (a) the motion signal to determine whether a change in motion exceeds a predetermined motion threshold and (b) the sound signal to determine whether a sequence of sensed sound signals within a predetermined period matches crash sound indicators of (i) glass breakage and (ii) metal folding.", "Upon determining the occurrence of the crash incident a display displays a possible event window for selection of one of (a) to return the mobile communications device to monitoring for the occurrence of the crash incident and (b) to confirm the crash incident.", "Upon a failure of selection of one of the selectable options within a predetermined period, the mobile communications device communicates by a communications network an identifier associated with the mobile communications device and crash incident information of a location data, date and time to the tracking and dispatch center.", "The tracking and dispatch center dispatches at least one response servicer to a site of the crash incident based on the location data.", "The response servicer provides a lantern device having a light, an imaging device, and a communications device.", "Images received by the imaging device communicate by the communications device through the network to the tracking and dispatch center.", "In yet another aspect, the present invention provides a method system for detecting a crash incident of a motor vehicle with crash detection response and reporting, comprising the steps of: (a) providing a mobile communications device having a sensor that generates a motion signal responsive to motion of the mobile communications device and a sound receiver for receiving a sound signal of sound proximate the mobile communications device, with software instructions configured for execution for monitoring for an occurrence of a crash event; (b) periodically interrogating (a) the motion signal to determine whether a change in motion exceeds a predetermined motion threshold and (b) the sound signal to determine whether a sequence of sensed sound signals within a predetermined period matches crash sound indicators of (i) glass breakage and (ii) metal folding; (c) based on interrogations of the motion signal and the sound signal, determining that the crash incident occurred; (d) making an alert as to the crash incident with the mobile communications device; (e) determining whether the alert generated a crash response through the mobile communications device, and if not, communicating a location data of the crash incident to a service provider for response; and (f) communicating a status of the service provider response to the mobile communications device.", "Objects, advantages, and features of the present invention may be readily determined upon a reading of the following detailed description in conjunction with the drawings and the appended claims." ], [ "TECHNICAL FIELD The present invention relates to apparatus and methods for responding to motor vehicle crash events.", "More particularly, the present invention relates to apparatus and methods for detecting the occurrence of a motor vehicle crash, responding to the detection of the motor vehicle crash, and reporting the detection of the motor vehicle crash.", "BACKGROUND OF THE INVENTION In recent years, improved roadways, traffic control devices, and safety devices that are installed and operated in motor vehicles have resulted in safer transportation by motor vehicle.", "Nevertheless, incidents and accidents involving car and truck motor vehicles continue to occur.", "These include vehicle-to-vehicle collisions as well as single vehicle accidents.", "While typically such incidents occur in locations where response personnel may be readily directed to provide medical and tow services, some incidents involving disappearance of the motor vehicle and its operation occur (such as a single vehicle accident in which the vehicle leaves the roadway and becomes hidden from view in woods or water).", "Also, monitoring services seek “how am I driving” reports typically for fleet operators to monitor driving activities of vehicle operators but parents having children as new or inexperienced drivers also have become interested in monitoring and reporting on motor vehicle operations.", "While systems having GPS location tracking features and cellular telecommunications devices have been installed in motor vehicles for communications between occupants and a tracking service provider, there are drawbacks to such systems.", "The operator may be injured or blocked from initiating communications.", "Also, the operator may be using a different vehicle such as a rental vehicle.", "Accordingly, there is a need in the art for an improved system and method for detecting occurrences of motor vehicle incidents, responding to detection of motor vehicle incident occurrences, and tracking and reporting on detection of and responses to motor vehicle incident occurrences.", "It is to such that the present invention is directed.", "BRIEF SUMMARY OF THE INVENTION The present invention meets the needs in the art by providing a system for detection of a crash of a motor vehicle with crash detection response and reporting, comprising a mobile communications device configured with a sensor that generates a motion signal responsive to changes in motion of the mobile communications device and a sound receiver for receiving a sound signal of sound proximate the mobile communications device, and including software instructions that upon execution monitors for an occurrence of a crash event by periodically interrogating (a) the motion signal to determine whether a change in motion exceeds a predetermined motion threshold and (b) the sound signal to determine whether a sequence of sensed sound signals within a predetermined period matches crash sound indicators of (i) glass breakage and (ii) metal folding.", "A display that upon determining the occurrence of the crash incident displays a possible event window with a selectable option (a) to return the mobile communications device to monitoring for the occurrence of the crash incident or (b) to confirm the crash incident.", "Upon a failure of selection of one of the selectable options within a predetermined period, communicating by a communications network an identifier associated with the mobile communications device and crash incident information including a location data to a tracking and dispatch center having a pre-registered record of the mobile communications device and configured for receiving and storing the acceleration information and the sound signals on which the crash incident was determined.", "The tracking and dispatch center is configured to dispatch a servicer to a site of the crash incident based on the location data.", "In another aspect, the present invention provides a motor vehicle crash detection system, comprising a tracking and dispatch center having a computer processor configured with an electronic memory device that maintains driver information of driver name, address, insurance company and policy number for a plurality of drivers and maintains vehicle crash information of motor vehicle, crash location data, date and time, and optionally one or more sequences of sounds from a crash location, one or more images thereof, for a plurality of crashed motor vehicles.", "A plurality of mobile communications devices, each associated with a respective one of the plurality of drivers are each configured with a sensor that generates a motion signal responsive to changes in motion of the mobile communications device and a sound receiver for receiving a sound signal of sound proximate the mobile communications device.", "The mobile communications device configured with software instructions that upon execution monitors for an occurrence of a crash event by periodically interrogating (a) the motion signal to determine whether a change in motion exceeds a predetermined motion threshold and (b) the sound signal to determine whether a sequence of sensed sound signals within a predetermined period matches crash sound indicators of (i) glass breakage and (ii) metal folding.", "Upon determining the occurrence of the crash incident a display displays a possible event window for selection of one of (a) to return the mobile communications device to monitoring for the occurrence of the crash incident and (b) to confirm the crash incident.", "Upon a failure of selection of one of the selectable options within a predetermined period, the mobile communications device communicates by a communications network an identifier associated with the mobile communications device and crash incident information of a location data, date and time to the tracking and dispatch center.", "The tracking and dispatch center dispatches at least one response servicer to a site of the crash incident based on the location data.", "The response servicer provides a lantern device having a light, an imaging device, and a communications device.", "Images received by the imaging device communicate by the communications device through the network to the tracking and dispatch center.", "In yet another aspect, the present invention provides a method system for detecting a crash incident of a motor vehicle with crash detection response and reporting, comprising the steps of: (a) providing a mobile communications device having a sensor that generates a motion signal responsive to motion of the mobile communications device and a sound receiver for receiving a sound signal of sound proximate the mobile communications device, with software instructions configured for execution for monitoring for an occurrence of a crash event; (b) periodically interrogating (a) the motion signal to determine whether a change in motion exceeds a predetermined motion threshold and (b) the sound signal to determine whether a sequence of sensed sound signals within a predetermined period matches crash sound indicators of (i) glass breakage and (ii) metal folding; (c) based on interrogations of the motion signal and the sound signal, determining that the crash incident occurred; (d) making an alert as to the crash incident with the mobile communications device; (e) determining whether the alert generated a crash response through the mobile communications device, and if not, communicating a location data of the crash incident to a service provider for response; and (f) communicating a status of the service provider response to the mobile communications device.", "Objects, advantages, and features of the present invention may be readily determined upon a reading of the following detailed description in conjunction with the drawings and the appended claims.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates a schematic overview of an illustrative embodiment of a crash detection, response, and reporting apparatus in accordance with the present invention.", "FIG.", "2 illustrates a process flow of an exemplary embodiment of an application for a mobile computer device configured for crash detection, response and reporting in accordance with the present invention.", "FIG.", "3 illustrates a screen image for operating the crash detection, response and reporting application.", "FIG.", "4 illustrates a screen image during monitoring the operation of the crash detection, response and reporting application.", "FIG.", "5 illustrates a crash detected screen displayed when the crash detection, response and reporting application determines that a possible crash event may have occurred.", "FIG.", "6 illustrates a screen image following detection of a possible crash event by the crash detection, response and reporting application.", "FIG.", "7 illustrates a screen image of the crash detection, response and reporting application after a request for assistance.", "FIG.", "8 illustrates a second screen image of the crash detection, response and reporting application after a request for assistance.", "Objects, advantages and features of the present invention of crash event detection, response and reporting apparatus and method will become readily apparent upon a reading of the following detailed description in reference to the drawings and the appended claims.", "DETAILED DESCRIPTION With reference to the drawings, in which like parts have like reference numerals, FIG.", "1 illustrates a schematic overview of an illustrative embodiment of a crash detection, response, and reporting apparatus 10 in accordance with the present invention.", "The apparatus 10 supports motor vehicle insurance and tracking services for drivers of motor vehicles 12 with a computer software application 14 configured for crash detection, response and reporting operable on a mobile communications device 16.The mobile communications device 16 includes a microprocessor device, communications module, and display.", "The mobile communications device includes, but is not limited to cellular telephone, tablet computer, laptop portable computer, or other similar microprocessor device configured with an operating system, information input devices (mouse, keyboard, touchscreen, actual or virtual), and a display device for presentation of information during operation of the application.", "For example, the possession of cellular telephones is becoming more prevalent.", "The application 14 resident on the cellular telephone in the possession of the driver during motor vehicle operation, and operating in a background mode, provides a passively present crash detection, response, and reporting feature for drivers as well as others having an interest in the status of the driver and the motor vehicle.", "The mobile communications device 16 includes conventionally an accelerometer 17a for detecting changes in linear acceleration and alternatively a gyroscope 17b (one or more axis) configured for detecting changes in angular rotation of the device.", "The accelerometer 17a and the gyroscope 17b detect changes in motion of the mobile communications device and thus may indicate changes in the status of the motor vehicle (i.e., especially a potential crash based on rapid changes in acceleration and/or rapid changes in angular rotation).", "The application 14 periodically interrogates and determines changes in motion of the mobile communications device (acceleration and/or angular rotation) by communicating with, and receiving one or more motion signals from the accelerometer 17a and from the gyroscope 17b.", "In an alternate embodiment, the accelerometer 17a and/or gyroscope 17b may be a separate device installed in the motor vehicle, which communicate with the mobile communications device 16.The apparatus 10 includes a central tracking/dispatch center 18, with a computer server or processor 20.The computer server 20 includes conventional memory or storage devices and is configured for maintaining (adding, updating, revising) a database 21 with information retained on the storage device.", "The database 21 of the tracking/dispatch center 18 receives and stores the motion information and the sound signals on which the crash incident was determined, upon communication from the mobile communications device of such information and signals through a communications network.", "Further, the database maintains driver information of driver name, address, insurance company and policy number for a plurality of drivers and maintains vehicle crash information of motor vehicle, crash location data, date and time, and optionally one or more sequences of sounds from a crash location, one or more images thereof, for a plurality of crashed motor vehicles.", "The computer server 20 is further configured for analyzing and reporting on the status of motor vehicles having information tracked though the database of the central tracking/dispatch center 18.The apparatus 10 includes one or more response services.", "These may be independent service providers or dependent providers related to the central tracking/dispatch center 18.The illustrated embodiment includes a plurality of tow truck service/features 22 as a response service.", "The response service includes a tow truck 22 and a portable lantern camera/communications device 24.The portable lantern device 24 includes a high-wattage light 25, a camera 27, and a communications device 29.The light 25 is selectively operable for night illumination.", "The camera 27 operates in video or still modes for imaging of the crash event, the site, the motor vehicle(s) involved, and creating other picture documentation related to the crash event.", "The communications device 29 provides two-way communications, such as cellular, wife, radio, or other, for communicating with the persons involved in the crash event, with the central tracking/dispatch center 18, with the tow service provider, or others as appropriate.", "Live images may be transmitted as appropriate, for example, but not limited to emergency care and services providers or the dispatcher 18.In the illustrated embodiment, the tow truck 23 optionally includes digital video recording and telecommunications equipment 19 (i.e.", "MDVR and multiple cameras) for communicating images to the server 20, as well as capturing multiple video images from the tow truck and from the portable lantern camera 24 that communicates with and through the telecommunications equipment.", "In yet another alternate embodiment, the lantern camera/MDVR 24 provides the on-site imaging functionality and there is no MDVR equipment mounted on the truck except for other wireless cameras carried, for example, in the truck or by other responders, which communicate through the lantern camera/MDVR 24 to the server 20.In an alternate embodiment, the portable lantern device 24 may be embodied in mobile communications device such as a cellphone equipped with a light emitting device, a video imager, and a transceiver device for cellular network communications, and a microprocessor.", "The microprocessor is configured with a software application for selectively activating the imager for receiving images (video or separate image) of a crash site, storing the images and selectively communicating the images through the network to receiver.", "The light provides lighting for night activities at a crash site.", "The apparatus 10 further includes a claims servicer 26 that provides motor vehicle claims information and processing services to insurance carriers and motor vehicle owners and operators such as fleet operators.", "The application 14, dispatch 18, ISP (independent service provider) 22, and the insurance claims servicer 26 communicate through a communications network generally 30 including wireless, cellular, telephony, radio (two-way), world wide web communications devices and connections, and other suitable electronic communications devices.", "The server 20 is configured with the database 21 for tracking motor vehicles and drivers registered with the service, through a fleet operator, an insurance company as a service for its insured, or independently such as parents of young drivers.", "Further, the apparatus 10 may gainfully be used by a fleet operator as an independent separate system.", "FIG.", "2 illustrates a process flow 50 of an exemplary embodiment of the application 14 operable with the mobile communications device 16 for crash detection, response and reporting in accordance with the present invention.", "The driver initiates 52 operation of the application 14.The application 14 may operate in a background mode of the mobile communications device so that other routine uses of the mobile communications device 16 (such as cellphone calls, internet access, email receiving and transmitting, mapping and routing directions, and other conventional uses) may proceed.", "The application 14 monitors 54 for indicators of a crash event.", "In the illustrative embodiment, detection of motion above a preset speed causes the application 14 to commence the crash detection monitoring functions.", "The mobile communications device 16 includes conventionally the accelerometer 17a, and the application 14 periodically interrogates the accelerometer by communicating with, and receiving an acceleration signal from, the accelerometer.", "An alternate embodiment includes the gyroscope 17b that detects changes in angular rotation.", "The application 14 in this embodiment periodically interrogates the gyroscope 17b for receiving angular rotation signals indicating rapid rotation of the mobile communication device (for example, rolling over of a motor vehicle).", "The mobile communications device 16 includes a sound receiver or microphone.", "The crash indicators include the motor vehicle motion signal and the sounds 58 received proximate the mobile communications device 16.The motion signal may be the acceleration 56 signals, the angular rotation signals 57, or both.", "The application 14 periodically receives 60 the motion information of the motor vehicle from the force monitoring device or accelerometer and alternatively the angular rotation signals 57 from the angular rotation measuring device.", "The application 14 also receives audio signals though the microphone.", "Rapid declaration, rapid changes in rotation, and glass breakage/metal folding sounds indicate a possible crash event.", "A crash indicator database 62 provides accident or crash event correlated motion and sounds thresholds.", "The information is processed 64 and compared with standards maintained in the database 62 to determine 65 whether a possible crash event has occurred.", "If not, the apparatus continues monitoring 66 for crash event signals.", "The use of multiple indicators of a crash event facilitates reduction of false alarms.", "Monitoring crash event indications 54 involves detecting sounds with a mobile device microphone that exceed a predetermined threshold, detecting changes in acceleration with 3-axis (x, y, z) accelerometers that exceed a predetermined threshold, and/or detecting changes in angular rotation that exceed a predetermined threshold.", "Upon detecting one or more high threshold events, the application 14 may check a GPS-based speed for evidence that the mobile communications device is slowing or rotating rapidly or has stopped moving.", "If the GPS-based speed is unchanged, the application 14 would reject 82 the detected event and return to crash monitoring 54.If the GPS-based speed indicated slowing/rotation/stopping, the processing of the sound and motion recording files, which would include recording for a predetermined period of pre-event sound and motion information and post-event recording of such information for a second predetermined period.", "In an illustrative embodiment, the application 14 maintains a continuous recording database of the motion and audio signals received during monitoring.", "The database is configured for maintaining a lead portion (pre-event) of a predetermined period preceding the possible crash event and a trailing portion (post-event) of a second predetermined period post-possible crash event.", "The recorded database uploads to the central tracking/dispatch center 18 during notification communication of a possible crash event to the central tracking/dispatch center 18.The database 21 of the tracking/dispatch center 18 receives and stores the motion information and the sound signals on which the crash incident was determined, upon communication from the mobile communications device 16 of such information and signals through a communications network 30.Further, the database 21 maintains driver information of driver name, address, insurance company and policy number for a plurality of drivers and maintains vehicle crash information of motor vehicle, crash location data, date and time, and optionally one or more sequences of sounds from a crash location, one or more images thereof, for a plurality of crashed motor vehicles.", "If the application determines 68 that a possible crash event has occurred, the application alerts 70 the driver.", "Determination of a possible crash event in the illustrative embodiment involves both sound and motion crash indicators being determined as true (i.e., exceeding respective predetermined thresholds).", "An exceeded sound threshold alone or an exceeded acceleration threshold alone or an exceed angular rotation alone may be rejected as indicating a crash event and processing would return to monitor 54.The combination may indicate a crash event.", "The alert 70 presents a visual message 104 (see FIG.", "5) on a display of the mobile communications device 16.The alert 70 may include an unmistakable audio tone at high volume to draw the driver's attention to the mobile communications device 16.The driver may respond in the negative and the application 14 then returns to the monitor 54 processes.", "If the driver confirms the crash event, the application presents 72 selective choices for calling 911 or emergency contact, contact the insurance carrier, request roadside assistance, or cancel, as discussed below in reference to FIG.", "6.If the driver does not respond 72 after a predetermined period of time (for example, but not limitation, a period of 60 seconds), the application 14 initiates assistance.", "This includes notification to emergency centers (such as to local police authorities) 74, notification 76 to the central tracking/dispatch center 18, and initial accident notification 78 to the claims service center 26.The application may also evaluate 80 whether the accelerometer and sounds information should be uploaded to the crash indicator database.", "The driver, upon being alerted to the possible crash event, may selectively respond for the system to ignore 82 the possible crash event (i.e., no crash event occurred); or 83 to initiate 84 telephone contact with appropriate local police authorities; to contact the insurance carrier 85 or to request 86 assistance.", "The application provides updates 88 to the driver as to the status of the requested assistance.", "Such updates for example, may include contact information for a tow truck operator and arrival time.", "The driver may select to cancel 89 the notifications and processing of crash event services by the application 14.The application 14 accordingly synchronizes the crash event with the motorists, the date and time of crash event, the place of the crash event, and the severity of the crash event.", "This information provides a basis for accident reconstruction, predictive indications of potential loss and injury, and also perfects the validity of the report of the crash event by the motorist involved while supporting official investigative reports.", "The detected and recorded motion information (i.e., the acceleration signal and the angular rotation signal) provide additional information useful for accident reconstruction evaluations.", "FIG.", "3 illustrates a screen image 100 for operating the crash detection, response and reporting application 14 on the mobile communications device 16.The application 14 displays an activate button 102.Operating the button 102 causes the application 14 to operate in the background of the mobile communications device 16, monitoring for a possible crash event, and responding appropriately, as discussed above.", "It is to be appreciated that the initiate screen 100 (and the monitoring screen 110 (FIG.", "4) are in an exemplary embodiment of a stand-alone application.", "A production application in an alternate embodiment such as provided to customers of an insurance provider, may embed the application 14 within a hosting application for the insured of the insurance provider or a similar hosting application with other consumer-facing features and services of the provider (for example, display a report of policy terms and limits, provide for changes to policy coverage, add, delete or modify driver and motor vehicle information, and other insurance servicing features.)", "FIG.", "4 illustrates the monitoring screen 110 that may be displayed during the monitor processing of the crash detection, response and reporting application 14.The screen 110 includes a status window 111.The status window displays a short descriptive phrase as to the status of the application 14 shown in Table 1 below: TABLE 1 Status Window Phrases Phrase Definition Crash Sensing - the application 14 is monitoring for a possible Monitoring crash event Crash Detected - the application 14 detects sound and motion Triggered information indicating a crash event may have occurred Crash Sensing - a crash event has occurred; the application 14 Confirmed provides action options for selection by the driver Crash Sensing - the crash event has been reported and status of Reported action options and of response servicers are displayed The window 111 in FIG.", "4 indicates that the application 14 is monitoring for a possible crash event.", "The application 14 monitors sound events, and may provide a real-time signal display 112 on the screen 110.Further, the screen 110 displays 114 the three axis acceleration of the motor vehicle.", "A cancel button 116 causes the application to cease operating.", "A “in-accident” button 118 enables the driver to initiate crash event processing by the application 14, including notification to the central tracking/dispatch center 18 that a crash event has occurred.", "In response to the “in-accident” button 118, the application 14 communicates crash information, vehicle information and driver information using the communications of the mobile communications device 16.A window 119 displays the driver and vehicle information.", "Alternatively, the display may present a graphic (not illustrated) of the motor vehicle based on the detected changes in the angular rotation of the mobile communications device 16.FIG.", "5 illustrates a crash detected screen 103 displayed when the application 14 determines that a possible crash event may have occurred.", "The screen 103 may be accompanied with an unmistakable audio tone at high volume to draw the driver's attention to the mobile device.", "The screen 103 displays a possible event window 104 that includes the time 104a and GPS coordinates 104b as well as the vehicle information 119 window.", "The screen 103 includes a “no accident—disregard” button 106 and an accident confirmation button 105 with text “Yes, I was in an accident.” The driver operates the “I was in an accident” button 105 to confirm the detection of a crash event.", "The driver operates the “no accident—disregard” button if the detection was incorrect as no crash incident had occurred.", "The “I was in an accident” button 118 shown in FIG.", "4 is for circumstances where the driver wants to proceed manually to report a crash event without the application detecting the crash event; FIG.", "5 provides the confirmation “accident” button 105 for the driver to confirm that the detection of the crash event by the application was correct.", "Both buttons 118 and 105 cause the application 14 to proceed to crash event processing in reference to FIG.", "6.The “no-accident—disregard” button 106 causes the application 14 to return to the monitoring screen 110 and monitoring as shown in FIG.", "4.FIG.", "6 illustrates a screen 120 displayed to the driver on the mobile communications device 16 following detection of a possible crash event by the crash detection, response and reporting application 14.The window 111 in FIG.", "6 indicates that the application 14 acknowledges or confirms receiving the crash event notice following the use of the confirm button 118.The screen 120 includes an insurance window 122 that displays the name and address of the insured; the make, model and vehicle identification number of the insured motor vehicle; and the insurance carrier and policy number.", "The screen 120 provides selectively actuated buttons to direct the activities of the application 14.A “call” button 123 causes the application 14 to imitate a telephone call to the insurance carrier.", "A “cancel” button 124 directs the application to resume monitoring for a possible crash event.", "The application 14 notifies the central tracking/dispatch center 18.A “call 911” button 126 directs the application 14 to initiate a telephone call to local emergency services such as local police and ambulance services.", "A “request assistance” button 128 initiates services from independent service providers 22.In the illustrated embodiment, the independent service provider 22 is a roadside assistance service.", "The application 14 communicates this request to the central tracking/dispatch center 18.The information communicated by the application 14 includes the vehicle identification number, the driver information and contact phone number, and the location, time, and event.", "A crash event window 129 displays crash event information including the report time, the location of the crash event (address, if determined), a geographical coordinate designation, and crash severity.", "The “cancel” button 124 cancels the reporting and status monitoring activities.", "Appropriate information for cancelation communicates from the mobile communication device 16, such as to the tracking/dispatch center 18 and/or the service provider 22.FIG.", "7 illustrates a screen 130 of the crash detection, response and reporting application 14 after a request for assistance is selected.", "The window 111 in FIG.", "7 indicates that the application 14 has reported the crash event.", "The screen 130 displays the insurance window 122 and the crash information window 129.Optionally, the screen 130 may display the time of detection of the crash event and the time the crash event was reported to the central tracking/dispatch center 18.The screen 130 includes an update field 134.The application 14 presents in the update field 134 the status of the requested assistance.", "This includes the type 136 of assistance requested, the time 138 the request was made, and the status 140 of the response.", "The screen 130 may include an initiate emergency call button 137.A cancel assistance button 139 communicates a cancellation notice to the independent service provider 22 and to the tracking/dispatch center 18.FIG.", "8 illustrates a second screen 150 of the crash detection, response and reporting application after a request for assistance, depicting updated assistance information 152.This may include the time of dispatch 154 and an estimate time of arrival 156.The update field may also present (not illustrated) the contact information of the tow truck driver.", "A call button 157 initiates telephonic communication with the operator of the tow truck.", "Optionally, a confirm arrival button enables the driver to communicate status information to the tracking/dispatch center 18.A cancel button 159 communicates a cancellation notice to the independent service provider 22 and to the tracking/dispatch center 18.Although not illustrated, the application 14 includes user setup screens for entry of driver and vehicle information.", "This information includes the driver name and address, insurance company and policy, and the vehicle identification number and make and model.", "The information uploads to the database 21 on the server 20.The native application, downloaded and installed on the mobile communications device 16, maintains background processes such as environmental monitoring that occurs.", "The environmental conditions for monitoring may be selected through appropriate control screens.", "For example, environmental monitoring may occur under conditions which correspond to the user driving or riding in a moving vehicle above a specified speed (e.g.", "5 mph).", "Optional detection of known vehicle RF emitters (e.g.", "BT or WiFi) may be used to enhance recognition of in-vehicle operation.", "That is, detection of RF signals may cause the application 14 to commence monitoring.", "In an alternate embodiment, the application 14 operates from a selection button provided through a hosting application such as provided as an SAAS web site of an insurance carrier or fleet operator.", "As discussed above, the environmental monitoring includes periodically receiving and evaluating x, y, z accelerometer outputs and/or gyroscope axis output (such as accelerometer or gyroscope devices embodied in the mobile communications device 16) and microphone (e.g.", "engine sounds, ambient sounds) for communication of sounds for analysis of possible crash events.", "In addition, the application may receive motor vehicle speed signals (either GPS or handset-based cellular assisted) and configured for translating to approximate vehicle x, y, z coordinates and thus speed and angular rotation.", "A determination of a significant possible crash event may be made upon detection of multiple ambient conditions, such as: high negative acceleration in the motor vehicle x or y axis, rapid negative change in vehicle speed, high or rapid changes in angular rotation, and sounds corresponding to vehicle impacts.", "An alternate embodiment includes spectral analysis for sounds of glass breaking and metal shearing, bending, folding, or otherwise experiencing high impact change, in the possible crash event determination.", "The determination is made based on a reasonable match of sounds from the event with sounds from known crash events.", "Such information may be maintained in a crash indicators database.", "Upon determination 65 of a significant possible crash event, actions may be initiated (automatically or selectively) which may include: a.", "Prompting 70 the mobile communications device 16 via screen message 104 and notification sound requesting driver confirmation 105, 106 whether a crash event has occurred and whether the driver wants to place an emergency 911 call.", "b.", "If the user confirms a crash, the application may immediately send 83 a message to third-party for roadside assistance initiation and also to the tracking/dispatch center 18.c.", "If the user does not respond to the application notification (e.g.", "because the driver is injured or otherwise unable to respond), the application may prompt the driver with an audible message to confirm verbally to call 911 via voice command.", "Optionally, the application may be configured to include the user/driver opting into an automatic crash notification feature which activates a speakerphone-based 911 call to permit a 911 operator to interrogate the driver hands-free.", "Upon initiation of the roadside assistance call, the application 14 may be used to communicate the status of roadside assistance response.", "This feature may be subject to the level of integration with the roadside assistance company or other service provider.", "The application of the present invention provides improved reporting of motor vehicle accident and crash information to persons having interest in the driver status (such as, parents, central tracking/dispatch, fleet operators, and others), while providing early initiation and first notice to the insurance claim service of the crash event, and providing dispatch of independent service provider services 22 such as tow truck services, though a machine-to-machine monitor, tracking, and notification system.", "The first notice available through the monitor, tracking, and notification system facilities claims processing by providing the identification of the insured motorist, the motor vehicle involved, the location of the vehicle and the crash event, and updates of the status.", "Further, the application in an alternate embodiment includes video/photo recording features following detection/confirmation of a crash event.", "This enables the driver to generate video/photo image files that may automatically upload to the tracking/dispatch center 18 and servers 20 to complement or substitute for tow truck-generated video/photo information.", "With reference to the drawings and FIGS.", "1 and 2, the system 10 detects the crash of the motor vehicle with crash detection device carried with the motor vehicle for crash response and reporting.", "The driver (or passenger) carries or brings into the motor vehicle the mobile communications device 16 configured with the sensor that generates the motion signal responsive to motion of the mobile communications device and a sound receiver for receiving a sound signal of sound proximate the mobile communications device.", "The motion signal may be the acceleration signal from the accelerometer 17a, the angular rotation signal from the gyroscope 17b, or both.", "The mobile communications device 16 configured with software instructions or application 14 that upon execution monitors for an occurrence of a crash event by periodically interrogating (a) the motion signal to determine whether a change in motion exceeds a predetermined motion threshold and (b) the sound signal to determine whether a sequence of sensed sound signals within a predetermined period matches crash sound indicators of (i) glass breakage and (ii) metal folding.", "A display that upon determining the occurrence of the crash incident displays a possible event window with a selectable option of the driver or passenger (a) to return the mobile communications device to monitoring for the occurrence of the crash incident or (b) to confirm the crash incident.", "Upon a failure of selection of one of the selectable options within a predetermined period, communicating by the communications network 30 an identifier associated with the mobile communications device 16 and crash incident information including the location data to a tracking and dispatch center 18 having a pre-registered record of the mobile communications device 16 and configured for receiving and storing the acceleration information and the sound signals on which the crash incident was determined.", "The servicer 22 dispatched by the tracking and dispatch center 18 responds to the site of the crash incident based on the location data.", "The claims service center 26 is configured for servicing an insurance claim arising from the crash incident as reported by the tracking and dispatch center 18.Additional incident services may be provided, such as providing through the servicer 22 a transport vehicle for transporting a damaged motor vehicle to the crash site and also providing insurance claims process services for the motor vehicle owner, operator and insurer including documentation, images, and accident incident details about the operation of the motor vehicle.", "With reference to FIGS.", "1 and 2, the system 10 in accordance with the present invention operates 52 for detecting a crash incident of the motor vehicle with crash detection response and reporting.", "The system 10 provides (a) the plurality of mobile communications devices 12 each carried by a driver or passenger in the motor vehicle.", "Each mobile communications device 12 has the motion sensor (accelerometer 52 as an acceleration sensor and/or gyroscope as an angular rotation sensor) that generates the motion signal responsive to motion of the mobile communications device 12 and the sound receiver for receiving a sound signal of sound proximate the mobile communications device.", "The mobile communications device 12 is configured with software instructions that upon execution monitors 54 (preferably in the background of the operation thereof) for the occurrence of a crash event.", "The software instructions are configured 64 for (b) periodically interrogating (a) the motion signal to determine whether the change in motion exceeds a predetermined threshold, (that is, of the accelerometer 56 to determine whether a change in acceleration exceeds a predetermined acceleration threshold and/or the gyroscope to determine whether a change in angular rotation exceeds a predetermined rotation threshold), and (b) the sound signal to determine whether a sequence of sensed sound signals within a predetermined period matches crash sound indicators of (i) glass breakage and (ii) metal folding.", "Then, (c) based on the interrogations of the motion signal(s) and the sound signal, the mobile communications device 12 determine 65 whether a crash incident occurred, and if so 68 the display of the mobile communications device 12 alerts the driver 70 and displays a possible event window 104 (see FIG.", "5) for selection by the driver of one of (a) return 106 the mobile communications device to monitoring 54 for the occurrence of a crash event and (b) to confirm 105 the crash event.", "In one aspect the mobile communications device (d) makes an alert, which may be audible or visual.", "In response, (e) determining 71 whether the alert generated a crash response by the driver through the mobile communications device, and if not, 72 communicating a location data of the crash incident to a service provider for response.", "For example, upon a failure of selection of one of the selectable options within a predetermined period, the mobile communications device 12 communicating by a communications network 30 an identifier associated with the mobile communications device and crash incident information of the location data, date and time to the tracking and dispatch center 18 for entry into the database 21.Further, the system 10 includes at least one response servicer 22 for dispatching by the tracking and dispatch center to the site of the crash incident based on the location data, the response servicer 22 providing the lantern device 24 having the light 25, the imaging device 27, and a communications device 29, whereby images received by the imaging device 27 communicate by the communications device 29 through the network 30 to the tracking and dispatch center 18.The images may be video or single frame.", "Further, (f) the tracking and dispatch center 18 communicating a status of the service provider 22 response to the mobile communications device 12.Alternatively, the response servicer 22 may provide the vehicle transporter (tow truck 23) for vehicle pull-out or movement at the crash site and for transport to a repair center or storage facility.", "The tow truck may include an electronic data storage device for communication with the imaging device and recording of images prior to communicating the recorded images to the tracking and dispatch center 18.An alternate embodiment includes alternative reporting and action path for commercial vehicle operators that addresses the difference in procedures for motor vehicles and trucks used in cartage.", "For example, the third party servicer may include cargo insurance carriers, emergency response teams for tracking and fleet operators, hazardous materials handling and clean-up services, salvage and similar such services.", "Such embodiment provides for simultaneous reporting and alternate claim information streams.", "The crash detection, response and reporting apparatus 10 according to the present invention establishes, occupies, and provides an effective interlinked network of a plurality of motor vehicles 12 each tracked locally during motor vehicle operation by a microprocessor-based application 14 that executes software code on the mobile communications device 16 of the driver, featuring communications networked driver/motor vehicle, central tracking/dispatch monitoring center 18, and attendant services including claims servicer 26 for an insurance carrier and support features for drivers such as tow truck services 22, for an end-to-end motor vehicle status tracking and reporting system featuring improved first notice of loss and machine-to-machine communicating between the motor vehicle, the monitoring center, and the services offering independent service providers (tow truck operators or claims servicers, for illustrative non-limiting examples), and enhanced revenue for insurance providers tracking motor vehicle status, incidents, and incident or accident reconstruction, documentation, and adjustment.", "The improved first notice of loss provided by the operation of the automated crash detection application 14 benefits insurance carriers, fleet operators, and individual motor vehicle operators by identifying the insured motorist or driver and the location of the incident involving the driver and the motor vehicle while providing coverage details to improve claims processing efficiencies and advance the handling and resolution of claims though automatic or manual reporting of incident occurrences and communication to service providers of assistance needs.", "The system tracks and monitors vehicle care and logistics, while further assisting with evaluation of accident causes and reconstruction for resolution purposes.", "The application 14 operates 52 in a background mode automatically or upon initiation by a driver and resolves locating insurance information from a wallet or storage within the motor vehicle.", "Independent service providers 22 such as tow truck operators benefit with automated identification of insured drivers, motor vehicle or incident location, and automatic or manual initiation of service support and response.", "Images of service response at the incident location are readily uploaded using the lantern 24 and the video and telecommunications equipment 19 of the service provider 22 to the monitoring center 18 to provide documentation for service fees while potentially reducing claims against service providers.", "Insurance claims servicers 26 obtain automated and seamless communications of identified motorist claimants and improved timely first notice of loss and further benefit with increased efficiency of services dispatch processing and handling of claims resolutions including as appropriate access and uploading of live video and audio from incidents.", "Fleet (as well as individual) motor vehicles operated by drivers registered with the central tracking/dispatch monitoring center 18 are readily monitored, assisted and reported on appropriately.", "Computer networks suitable for use with the embodiments described herein include local area networks (LAN), wide area networks (WAN), Internet, or other connection services and network variations such as the world wide web, the public internet, a private internet, a private computer network, a public network, a mobile network, a cellular network, a value-added network, and the like.", "Computing devices coupled or connected to the network may be any microprocessor controlled device that permits access to the network, including terminal devices, such as personal computers, workstations, servers, mini computers, main-frame computers, laptop computers, mobile computers, palm top computers, hand held computers, mobile phones, TV set-top boxes, or combinations thereof.", "The computer network may include one of more LANs, WANs, Internets, and computers.", "The computers may serve as servers, clients, or a combination thereof.", "The crash detection, response and reporting apparatus and method can be a component of a single system, multiple systems, and/or geographically separate systems.", "The crash detection, response and reporting apparatus and method can also be a subcomponent or subsystem of a single system, multiple systems, and/or geographically separate systems.", "The crash detection, response and reporting components can be coupled to one or more other components (not shown) of a host system or a system coupled to the host system.", "One or more components of the crash detection, response and reporting apparatus and method and/or a corresponding interface, system or application to which the crash detection, response and reporting apparatus is coupled or connected includes and/or runs under and/or in association with a processing system.", "The processing system includes any collection of processor-based devices or computing devices operating together, or components of processing systems or devices, as is known in the art.", "For example, the processing system can include one or more of a portable computer, portable communication device operating in a communication network, and/or a network server.", "The portable computer can be any of a number and/or combination of devices selected from among personal computers, personal digital assistant devices, portable computing devices, and portable communication devices, but is not so limited.", "The processing system can include components within a larger computer system.", "The processing system of an embodiment includes at least one processor and at least one memory device or subsystem.", "The processing system can also include or be coupled to at least one database.", "The term “processor” as generally used herein refers to any logic processing unit, such as one or more central processing units (CPUs), digital signal processors (DSPs), application-specific integrated circuits (ASIC), etc.", "The processor and memory can be monolithically integrated onto a single chip, distributed among a number of chips or components, and/or provided by some combination of algorithms.", "The methods described herein can be implemented in one or more of software algorithm(s), programs, firmware, hardware, components, circuitry, in any combination.", "The components of any system that include the crash detection, response and reporting apparatus and method can be located together or in separate locations.", "Communication paths couple the components and include any medium for communicating or transferring files among the components.", "The communication paths include wireless connections, wired connections, and hybrid wireless/wired connections.", "The communication paths also include couplings or connections to networks including local area networks (LANs), metropolitan area networks (MANs), wide area networks (WANs), proprietary networks, interoffice or backend networks, and the Internet.", "Furthermore, the communication paths include but are not limited to, removable fixed mediums like floppy disks, hard disk drives, and CD-ROM disks, as well as flash RAM, Universal Serial Bus (USB) connections, RS-232 connections, telephone lines, buses, and electronic mail messages.", "Aspects of the crash detection, response and reporting apparatus and corresponding systems and methods described herein may be implemented as functionality programmed into any of a variety of circuitry, including programmable logic devices (PLDs), such as field programmable gate arrays (FPGAs), programmable array logic (PAL) devices, electrically programmable logic and memory devices and standard cell-based devices, as well as application specific integrated circuits (ASICs).", "Some other possibilities for implementing aspects of the crash detection, response and reporting apparatus and method and corresponding systems and methods include: microcontrollers with memory (such as electronically erasable programmable read only memory (EEPROM)), embedded microprocessors, firmware, software, etc.", "Furthermore, aspects of the crash detection, response and reporting apparatus and method and corresponding systems and methods may be embodied in microprocessors having software-based circuit emulation, discrete logic (sequential and combinatorial), custom devices, fuzzy (neural) logic, quantum devices, and hybrids of any of the above device types.", "Of course the underlying device technologies may be provided in a variety of component types, e.g., metal-oxide semiconductor field-effect transistor (MOSFET) technologies like complementary metal-oxide semiconductor (CMOS), bipolar technologies like emitter-coupled logic (ECL), polymer technologies (e.g., silicon-conjugated polymer and metal-conjugated polymer-metal structures), mixed analog and digital, etc.", "It should be noted that any system, method, and/or other components disclosed herein may be described using computer aided design tools and expressed (or represented), as data and/or instructions embodied in various computer-readable media, in terms of their behavioral, register transfer, logic component, transistor, layout geometries, and/or other characteristics.", "Computer-readable media in which such formatted data and/or instructions may be embodied include, but are not limited to, non-volatile storage media in various forms (e.g., optical, magnetic or semiconductor storage media) and carrier waves that may be used to transfer such formatted data and/or instructions through wireless, optical, or wired signaling media or any combination thereof.", "Examples of transfers of such formatted data and/or instructions by carrier waves include, but are not limited to, transfers (uploads, downloads, e-mail, etc.)", "over the Internet and/or other computer networks via one or more data transfer protocols (e.g., HTTP, FTP, SMTP, etc.).", "When received within a computer system via one or more computer-readable media, such data and/or instruction-based expressions of the above described components may be processed by a processing entity (e.g., one or more processors) within the computer system in conjunction with execution of one or more other computer programs.", "Unless the context clearly requires otherwise, throughout the description and the claims, the words “comprise,” “comprising,” and the like are to be construed in an inclusive sense as opposed to an exclusive or exhaustive sense; that is to say, in a sense of “including, but not limited to.” Words using the singular or plural number also include the plural or singular number respectively.", "Additionally, the words “herein,” “hereunder,” “above,” “below,” and words of similar import, when used in this application, refer to this application as a whole and not to any particular portions of this application.", "When the word “or” is used in reference to a list of two or more items, that word covers all of the following interpretations of the word: any of the items in the list, all of the items in the list and any combination of the items in the list.", "The above description of embodiments of the crash detection, response and reporting apparatus and method and the corresponding systems and methods is not intended to be exhaustive or to limit the systems and methods to the precise forms disclosed.", "While specific embodiments of, and examples for, the crash detection, response and reporting apparatus and method and corresponding systems and methods are described herein for illustrative purposes, various equivalent modifications are possible within the scope of the systems and methods, as those skilled in the relevant art will recognize.", "The teachings of the crash detection, response and reporting apparatus and method and corresponding systems and methods provided herein can be applied to other systems and methods, not only for the systems and methods described above.", "The elements and actions of the various embodiments described above can be adapted, modified, and combined to provide further embodiments in accordance with the present invention of the crash detection, response and reporting apparatus and methods and corresponding systems and methods in light of the above detailed description.", "While this invention has been described in detail with particular reference to illustrative, non-limiting embodiments thereof, the principles and modes of operation of the present invention have been described in the foregoing specification.", "The invention is not to be construed as limited to the particular forms disclosed because these are regarded as illustrative rather than restrictive.", "Moreover, those skilled in the art may make modifications, variations and changes thereto without departure from the spirit and scope of the invention as described by the following claims." ] ]
Patent_15875949
[ [ "DATA SYNCHRONIZATION MANAGEMENT", "In general, a data synchronization management system is disclosed in which files (and/or other data) are synchronized among two or more client computing devices in connection with a backup of those files.", "Synchronization polices specify files to be synchronized based on selected criteria including file data, metadata, and location information.", "In general, files are initially copied from a primary client computing device to secondary storage.", "Thereafter, files to be synchronized are identified from the secondary storage, and copied to other client computing devices.", "Additionally, synchronized files may be viewed and accessed through a cloud and/or remote file access interface." ], [ "1.", "(canceled) 2.A data synchronization management system executed by software instructions in one or more hardware processors comprising: client computing device associated with a primary storage device and connected to a secondary storage computing device; secondary storage computing device, wherein the secondary storage computing device includes a media agent, media agent database, and a media agent index, and is associated with a secondary storage device; and the storage manager, wherein the storage manager further includes: a management database, wherein the management database further includes information management policies, synchronization policies, and a management index; a management agent; and a synchronization agent, wherein the synchronization agent manages synchronization of data between the primary storage device associated with the client computing device and the secondary storage device associated with the secondary storage computing device based on synchronization policies, and wherein the synchronization agent restores the secondary copy to another client computing device.", "3.A data synchronization management system of claim 2, wherein the synchronization agent further tracks synchronization information related to the data stored on the primary storage device, and data stored on the secondary storage device.", "4.A data synchronization management system of claim 2, wherein the synchronization agent further tracks conflicts between data located on the primary storage device and data stored on the secondary storage device.", "5.A data synchronization management system of claim 4, wherein the synchronization agent further resolves the conflicts between data located on the primary storage device and data stored on the secondary storage device.", "6.A data synchronization management system of claim 2, wherein the synchronization agent further manages the synchronization policies.", "7.A data synchronization management system of claim 2, wherein the synchronization agent further provides direct access to data stored in secondary storage device through a cloud interface.", "8.A data synchronization management system of claim 2, wherein the synchronization policies are stored in a data structure.", "9.A data synchronization management system of claim 2, wherein the data synchronization management system utilizes the information management policies for specifying and executing information management operations.", "10.A data synchronization management system executed by software instructions in one or more hardware processors comprising: a first client computing device associated with a first primary storage device and connected to a secondary storage computing device; a second client computing device associated with a second primary storage device and connected to the secondary storage computing device; secondary storage computing device, wherein the secondary storage computing device includes a media agent and is associated with a secondary storage device; and the storage manager, wherein the storage manager further includes: a management database, wherein the management database further includes synchronization policies, and a synchronization agent, wherein the synchronization agent, based on at least one of the synchronization policies, creates a secondary copy of data located on the first primary storage device, and automatically restores the secondary copy to the second primary storage device associated with the second client computing device.", "11.A data synchronization management system of claim 10, wherein the synchronization agent restores the secondary copy to the second primary storage device in the native format.", "12.A data synchronization management system executed by software instructions in one or more hardware processors comprising: client computing device associated with a primary storage device and connected to a secondary storage computing device; secondary storage computing device, wherein the secondary storage computing device is associated with a secondary storage device, and includes a media agent; and the storage manager, wherein the storage manager further includes: a management database, wherein the management database further includes synchronization policies, and a synchronization agent, wherein the synchronization agent manages synchronization of data between the primary storage device associated with the client computing device and the secondary storage device associated with the secondary storage computing device based on synchronization policies, and wherein the synchronization agent restores the secondary copy to another client computing device.", "13.A data synchronization management system of claim 12, wherein the management database further includes information management, a management index, and a management agent.", "14.A data synchronization management system of claim 12, wherein the secondary storage computing device includes a media agent database and a media agent index.", "15.A data synchronization management system of claim 12, wherein the synchronization agent further tracks synchronization information related to the data stored on the primary storage device, and data stored on the secondary storage device.", "16.A data synchronization management system of claim 12, wherein the synchronization agent further tracks conflicts between data located on the primary storage device and data stored on the secondary storage device.", "17.A data synchronization management system of claim 16, wherein the synchronization agent further resolves the conflicts between data located on the primary storage device and data stored on the secondary storage device.", "18.A data synchronization management system of claim 12, wherein the synchronization agent further manages the synchronization policies.", "19.A data synchronization management system of claim 12, wherein the synchronization agent further provides direct access to data stored in secondary storage device through a cloud interface.", "20.A data synchronization management system of claim 12, wherein the synchronization policies are stored in a data structure.", "21.A data synchronization management system of claim 12, wherein the data synchronization management system utilizes information management policies for specifying and executing information management operations." ], [ "<SOH> BACKGROUND <EOH>Businesses worldwide recognize the commercial value of their data and seek reliable, cost-effective ways to protect the information stored on their computer networks while minimizing impact on productivity.", "Protecting information is often part of a routine process that is performed within an organization.", "A company might back up critical computing systems such as databases, file servers, web servers, and so on as part of a daily, weekly, or monthly maintenance schedule.", "The company may similarly protect computing systems used by each of its employees, such as those used by an accounting department, marketing department, engineering department, and so forth.", "Given the rapidly expanding volume of data under management, companies also continue to seek innovative techniques for managing data growth, in addition to protecting data.", "For instance, companies often implement migration techniques for moving data to lower cost storage over time and data reduction techniques for reducing redundant data, pruning lower priority data, etc.", "Enterprises also increasingly view their stored data as a valuable asset.", "Along these lines, customers are looking for solutions that not only protect and manage, but also leverage their data.", "For instance, solutions providing data analysis capabilities, improved data presentation and access features, data synchronization, and the like, are in increasing demand." ], [ "<SOH> SUMMARY <EOH>Generally described, aspects of the present disclosure are directed to a data synchronization management system that may synchronize files (and/or other data) among two or more client computing devices, in addition to backing up the files.", "In an embodiment, a user of the data synchronization management system may specify one or more file synchronization policies.", "A file synchronization policy may specify the files that are to be synchronized, as well as the devices and locations to which those files are to be synchronized.", "For example, a user may create file synchronization policy and specify that all the files in a particular directory on their laptop are to be synchronized.", "Further, the user may specify that those files are to be synchronized to their desktop computer.", "The user may also optionally specify a synchronization schedule, and/or a one-way or two-way file synchronization.", "The data synchronization management system may work in conjunction with data backup policies.", "In an embodiment, a file synchronization proceeds as follows.", "Specified files are backed up or otherwise copied from the source client computing device to a secondary backup storage.", "The files to be synchronized are identified based both on the synchronization policy, and whether or not they have changed since the last backup.", "Thus, if a file backed up (and to be synchronized) is unchanged as compared to the previously backed up copy, that file is not synchronized.", "Any files identified for synchronization are synchronized to the one or more destination client computing devices, which are specified according to the synchronization policy of the user.", "In an embodiment, a user may specify the files to be synchronized.", "Files to be synchronized may be directly selected or otherwise identified, or criteria may be specified to indirectly identify the files to be synchronized.", "For instance, without limitation, files may be identified by detecting the existence of specified content within the file (such as the existence of one or more specified terms within a document), and/or by matching metadata associated with the file with one or more specified metadata parameters (such as filename, file owner, directory, creation date, modification date, size, type, location, Global Positioning System (GPS) coordinates, among others).", "The criteria used to identify files to be synchronized can vary.", "For example, files to be synchronized may be identified as the files in a certain directory that were created after a certain date.", "In an embodiment, the data synchronization management system may add location information to files that are backed up.", "Thus, a file to be synchronized may be identified according to the geographic location at which it was created and/or modified.", "Location information may include, for example, GPS coordinates gathered by the client computing device including, for example, a GPS receiver.", "In an embodiment, a user of the data synchronization management system may access synchronized files through a cloud and/or remote file access interface.", "For example, the user may access their files through a web browser after their identity is authenticated.", "In this embodiment, a file list may initially be accessible by the user.", "Thereafter, a user may request access to a particular file.", "At this point the requested file data may be transferred from a secondary storage (backup) to the user's computer so that the user may access the file.", "For purposes of summarizing the disclosure, certain aspects, advantages and novel features thereof have been described herein.", "Of course, it is to be understood that not necessarily all such aspects, advantages or features will be embodied in any particular embodiment of the invention.", "According to an embodiment, a computer-implemented method of synchronizing files between multiple client computers using file data is disclosed, the computer-implemented method comprising: accessing, by a synchronization module executing in computer hardware comprising one or more computer processors, user-defined synchronization criteria for identifying files to synchronize between a first primary storage device associated with a first client computing device and a second primary storage device associated with a second client computing device; reviewing, by the synchronization module, metadata associated with each of one or more files in a secondary copy, the secondary copy created during a secondary copy operation in which the one or more files stored in the first primary storage device are copied to one or more secondary storage devices to create a secondary copy including the one or more files; based at least in part on a review of the accessed metadata, identifying, by the synchronization module, at least one file in the secondary copy that meets the synchronization criteria for synchronization between the first primary storage device and the second primary storage device; accessing the at least one file; and communicating the accessed at least one file to the second client computing device for storage in the second primary storage device to synchronize the at least one file between the first primary storage device and the second primary storage device.", "According to an aspect, said communicating comprises communicating a copy of the at least one file that is accessed from the one or more secondary storage devices.", "According to an aspect, said identifying is in response to the secondary copy operation.", "According to an aspect, at least some of the metadata associated with each of the one or more files in the secondary copy is created following the initiation of the secondary copy operation.", "According to an aspect, at least some of the metadata associated with each of the one or more files in the secondary copy is created by the first client computing device prior to the initiation of the secondary copy operation.", "According to an aspect the method further comprises: determining characteristics associated with each of the one or more files stored in the first primary storage device; after the initiation of the secondary copy operation, for each of the one or more files copied to one or more secondary storage devices: based on the user-defined synchronization criteria and the determined characteristics, generating, by the synchronization module, an indication of whether the file is to be synchronized between the first primary storage device and the second primary storage device; and including the indication with the metadata associated with the file, wherein the at least one file in the secondary copy to synchronize is identified based on the indication.", "According to an aspect, the accessed metadata includes at least one of a file name, a file owner, a file directory, a creation date, a modification date, a file size, a file type, or a geographical location.", "According to an aspect, the method further comprises analyzing the contents of the at least one file, wherein the metadata includes content metadata relating to the analyzed content.", "According to an aspect, the user-defined synchronization criteria specifies files for synchronization based at least in part on the content metadata indicating the existence of one or more terms within the file.", "According to an aspect, the at least one file communicated to the second client computing device replaces a previous version of the at least one file stored in the second primary storage device.", "According to another embodiment, a system for synchronizing files between multiple client computers using file data is disclosed, the system comprising: a data store; and a synchronization module executing in computer hardware comprising one or more computer processors and configured to: access user-defined synchronization criteria from the data store for identifying files to synchronize between a first primary storage device associated with a first client computing device and a second primary storage device associated with a second client computing device; access file data associated with each of one or more files in a secondary copy, the secondary copy created during a secondary copy operation in which the one or more files stored in the first primary storage device are copied to one or more secondary storage devices to create a secondary copy including the one or more files; based at least in part on a review of the accessed metadata, identify at least one file in the secondary copy that meets the synchronization criteria for synchronization between the first primary storage device and the second primary storage device; access the at least one file; and communicate the accessed at least one file to the second client computing device for storage in the second primary storage device to synchronize the at least one file between the first primary storage device and the second primary storage device.", "According to an aspect, the metadata includes content metadata relating to the content of the at least one file and the synchronization criteria specifies files for synchronization based at least in part on content metadata.", "According to an aspect, the user-defined synchronization criteria specifies files for synchronization based at least in part on the content metadata indicating the existence of one or more terms within the file.", "According to an aspect, the accessed file data associated with each of the one or more files in the secondary copy is created following the initiation of the secondary copy operation.", "According to an aspect, the at least one file communicated to the second client computing device replaces a previous version of the at least one file stored in the second primary storage device.", "According to an aspect, the copy of the at least one file that is communicated to the second client computing device is accessed from the one or more secondary storage devices.", "According to an aspect, the identification of the at least one file is performed is in response to the secondary copy operation.", "According to yet another embodiment, a networked data storage system for synchronizing files between multiple client computers using file data is disclosed, the system comprising: a first client computing device; a second client computing device; at least one first primary storage device associated with the first client computing device; at least one second primary storage device associated with the second client computing device; one or more secondary storage devices; and computer hardware comprising one or more computer processors and having a synchronization module executing thereon, the synchronization module configured to: access user-defined synchronization criteria for identifying files to synchronize between a first primary storage device associated with a first client computing device and a second primary storage device associated with a second client computing device; access file data associated with each of the one or more files in the secondary copy, the secondary copy created during a secondary copy operation in which one or more files stored in the first primary storage device are copied to one or more secondary storage devices to create a secondary copy including the one or more files; based at least in part on a review of the accessed file data, identify at least one file in the secondary copy that meets the synchronization criteria for to synchronization between the first primary storage device and the second primary storage device; access the at least one file; and communicate the accessed at least one file to the second client computing device for storage in the second primary storage device to synchronize the at least one file between the first primary storage device and the second primary storage device.", "According to an aspect, the identification of the at least one file is performed in response to the secondary copy operation.", "According to an aspect, the copy of the at least one file that is communicated to the second client computing device is accessed from the one or more secondary storage devices." ], [ "CROSS-REFERENCE TO RELATED APPLICATION Any and all applications for which a foreign or domestic priority claim is identified in the Application Data Sheet as filed with the present application are hereby incorporated by reference under 37 CFR 1.57.BACKGROUND Businesses worldwide recognize the commercial value of their data and seek reliable, cost-effective ways to protect the information stored on their computer networks while minimizing impact on productivity.", "Protecting information is often part of a routine process that is performed within an organization.", "A company might back up critical computing systems such as databases, file servers, web servers, and so on as part of a daily, weekly, or monthly maintenance schedule.", "The company may similarly protect computing systems used by each of its employees, such as those used by an accounting department, marketing department, engineering department, and so forth.", "Given the rapidly expanding volume of data under management, companies also continue to seek innovative techniques for managing data growth, in addition to protecting data.", "For instance, companies often implement migration techniques for moving data to lower cost storage over time and data reduction techniques for reducing redundant data, pruning lower priority data, etc.", "Enterprises also increasingly view their stored data as a valuable asset.", "Along these lines, customers are looking for solutions that not only protect and manage, but also leverage their data.", "For instance, solutions providing data analysis capabilities, improved data presentation and access features, data synchronization, and the like, are in increasing demand.", "SUMMARY Generally described, aspects of the present disclosure are directed to a data synchronization management system that may synchronize files (and/or other data) among two or more client computing devices, in addition to backing up the files.", "In an embodiment, a user of the data synchronization management system may specify one or more file synchronization policies.", "A file synchronization policy may specify the files that are to be synchronized, as well as the devices and locations to which those files are to be synchronized.", "For example, a user may create file synchronization policy and specify that all the files in a particular directory on their laptop are to be synchronized.", "Further, the user may specify that those files are to be synchronized to their desktop computer.", "The user may also optionally specify a synchronization schedule, and/or a one-way or two-way file synchronization.", "The data synchronization management system may work in conjunction with data backup policies.", "In an embodiment, a file synchronization proceeds as follows.", "Specified files are backed up or otherwise copied from the source client computing device to a secondary backup storage.", "The files to be synchronized are identified based both on the synchronization policy, and whether or not they have changed since the last backup.", "Thus, if a file backed up (and to be synchronized) is unchanged as compared to the previously backed up copy, that file is not synchronized.", "Any files identified for synchronization are synchronized to the one or more destination client computing devices, which are specified according to the synchronization policy of the user.", "In an embodiment, a user may specify the files to be synchronized.", "Files to be synchronized may be directly selected or otherwise identified, or criteria may be specified to indirectly identify the files to be synchronized.", "For instance, without limitation, files may be identified by detecting the existence of specified content within the file (such as the existence of one or more specified terms within a document), and/or by matching metadata associated with the file with one or more specified metadata parameters (such as filename, file owner, directory, creation date, modification date, size, type, location, Global Positioning System (GPS) coordinates, among others).", "The criteria used to identify files to be synchronized can vary.", "For example, files to be synchronized may be identified as the files in a certain directory that were created after a certain date.", "In an embodiment, the data synchronization management system may add location information to files that are backed up.", "Thus, a file to be synchronized may be identified according to the geographic location at which it was created and/or modified.", "Location information may include, for example, GPS coordinates gathered by the client computing device including, for example, a GPS receiver.", "In an embodiment, a user of the data synchronization management system may access synchronized files through a cloud and/or remote file access interface.", "For example, the user may access their files through a web browser after their identity is authenticated.", "In this embodiment, a file list may initially be accessible by the user.", "Thereafter, a user may request access to a particular file.", "At this point the requested file data may be transferred from a secondary storage (backup) to the user's computer so that the user may access the file.", "For purposes of summarizing the disclosure, certain aspects, advantages and novel features thereof have been described herein.", "Of course, it is to be understood that not necessarily all such aspects, advantages or features will be embodied in any particular embodiment of the invention.", "According to an embodiment, a computer-implemented method of synchronizing files between multiple client computers using file data is disclosed, the computer-implemented method comprising: accessing, by a synchronization module executing in computer hardware comprising one or more computer processors, user-defined synchronization criteria for identifying files to synchronize between a first primary storage device associated with a first client computing device and a second primary storage device associated with a second client computing device; reviewing, by the synchronization module, metadata associated with each of one or more files in a secondary copy, the secondary copy created during a secondary copy operation in which the one or more files stored in the first primary storage device are copied to one or more secondary storage devices to create a secondary copy including the one or more files; based at least in part on a review of the accessed metadata, identifying, by the synchronization module, at least one file in the secondary copy that meets the synchronization criteria for synchronization between the first primary storage device and the second primary storage device; accessing the at least one file; and communicating the accessed at least one file to the second client computing device for storage in the second primary storage device to synchronize the at least one file between the first primary storage device and the second primary storage device.", "According to an aspect, said communicating comprises communicating a copy of the at least one file that is accessed from the one or more secondary storage devices.", "According to an aspect, said identifying is in response to the secondary copy operation.", "According to an aspect, at least some of the metadata associated with each of the one or more files in the secondary copy is created following the initiation of the secondary copy operation.", "According to an aspect, at least some of the metadata associated with each of the one or more files in the secondary copy is created by the first client computing device prior to the initiation of the secondary copy operation.", "According to an aspect the method further comprises: determining characteristics associated with each of the one or more files stored in the first primary storage device; after the initiation of the secondary copy operation, for each of the one or more files copied to one or more secondary storage devices: based on the user-defined synchronization criteria and the determined characteristics, generating, by the synchronization module, an indication of whether the file is to be synchronized between the first primary storage device and the second primary storage device; and including the indication with the metadata associated with the file, wherein the at least one file in the secondary copy to synchronize is identified based on the indication.", "According to an aspect, the accessed metadata includes at least one of a file name, a file owner, a file directory, a creation date, a modification date, a file size, a file type, or a geographical location.", "According to an aspect, the method further comprises analyzing the contents of the at least one file, wherein the metadata includes content metadata relating to the analyzed content.", "According to an aspect, the user-defined synchronization criteria specifies files for synchronization based at least in part on the content metadata indicating the existence of one or more terms within the file.", "According to an aspect, the at least one file communicated to the second client computing device replaces a previous version of the at least one file stored in the second primary storage device.", "According to another embodiment, a system for synchronizing files between multiple client computers using file data is disclosed, the system comprising: a data store; and a synchronization module executing in computer hardware comprising one or more computer processors and configured to: access user-defined synchronization criteria from the data store for identifying files to synchronize between a first primary storage device associated with a first client computing device and a second primary storage device associated with a second client computing device; access file data associated with each of one or more files in a secondary copy, the secondary copy created during a secondary copy operation in which the one or more files stored in the first primary storage device are copied to one or more secondary storage devices to create a secondary copy including the one or more files; based at least in part on a review of the accessed metadata, identify at least one file in the secondary copy that meets the synchronization criteria for synchronization between the first primary storage device and the second primary storage device; access the at least one file; and communicate the accessed at least one file to the second client computing device for storage in the second primary storage device to synchronize the at least one file between the first primary storage device and the second primary storage device.", "According to an aspect, the metadata includes content metadata relating to the content of the at least one file and the synchronization criteria specifies files for synchronization based at least in part on content metadata.", "According to an aspect, the user-defined synchronization criteria specifies files for synchronization based at least in part on the content metadata indicating the existence of one or more terms within the file.", "According to an aspect, the accessed file data associated with each of the one or more files in the secondary copy is created following the initiation of the secondary copy operation.", "According to an aspect, the at least one file communicated to the second client computing device replaces a previous version of the at least one file stored in the second primary storage device.", "According to an aspect, the copy of the at least one file that is communicated to the second client computing device is accessed from the one or more secondary storage devices.", "According to an aspect, the identification of the at least one file is performed is in response to the secondary copy operation.", "According to yet another embodiment, a networked data storage system for synchronizing files between multiple client computers using file data is disclosed, the system comprising: a first client computing device; a second client computing device; at least one first primary storage device associated with the first client computing device; at least one second primary storage device associated with the second client computing device; one or more secondary storage devices; and computer hardware comprising one or more computer processors and having a synchronization module executing thereon, the synchronization module configured to: access user-defined synchronization criteria for identifying files to synchronize between a first primary storage device associated with a first client computing device and a second primary storage device associated with a second client computing device; access file data associated with each of the one or more files in the secondary copy, the secondary copy created during a secondary copy operation in which one or more files stored in the first primary storage device are copied to one or more secondary storage devices to create a secondary copy including the one or more files; based at least in part on a review of the accessed file data, identify at least one file in the secondary copy that meets the synchronization criteria for to synchronization between the first primary storage device and the second primary storage device; access the at least one file; and communicate the accessed at least one file to the second client computing device for storage in the second primary storage device to synchronize the at least one file between the first primary storage device and the second primary storage device.", "According to an aspect, the identification of the at least one file is performed in response to the secondary copy operation.", "According to an aspect, the copy of the at least one file that is communicated to the second client computing device is accessed from the one or more secondary storage devices.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1A is a block diagram illustrating an exemplary information management system.", "FIG.", "1B is a detailed view of a primary storage device, a secondary storage device, and some examples of primary data and secondary copy data.", "FIG.", "1C is a block diagram of an exemplary information management system including a storage manager, one or more data agents, and one or more media agents.", "FIG.", "1D is a block diagram illustrating a scalable information management system.", "FIG.", "1E illustrates certain secondary copy operations according to an exemplary storage policy.", "FIG.", "2 is a block diagram illustrating an exemplary information management system configured to implement synchronization management, according to an embodiment of the present disclosure.", "FIG.", "3 illustrates an example data synchronization management process, according to an embodiment of the present disclosure.", "FIG.", "4 illustrates an example data synchronization management process including designation of particular files, according to an embodiment of the present disclosure.", "FIG.", "5 illustrates an example data synchronization management process including location metadata, according to an embodiment of the present disclosure.", "FIG.", "6 illustrates an example remote file access process, according to an embodiment of the present disclosure.", "FIGS.", "7A-G illustrate exemplary screenshots of pages of a user interface of a data synchronization management system, according to various embodiments of the present disclosure.", "DETAILED DESCRIPTION Systems and methods are described herein for synchronizing files or other data.", "For instance, techniques are described for synchronizing files between multiple client computing devices in a data storage system.", "The synchronization can be in response to, or otherwise in conjunction with, backup or other secondary copy operations.", "The data synchronization components and techniques may be incorporated within, implemented by, or otherwise compatible with information management systems such as those that will now be described with respect to FIGS.", "1A-1E.", "Data synchronization is described in further detail with respect to FIGS.", "2-7G.", "Information Management System Overview With the increasing importance of protecting and leveraging data, organizations simply cannot afford to take the risk of losing critical data.", "Moreover, runaway data growth and other modern realities make protecting and managing data an increasingly difficult task.", "There is therefore a need for efficient, powerful, and user-friendly solutions for protecting and managing data.", "Depending on the size of the organization, there are typically many data production sources which are under the purview of tens, hundreds, or even thousands of employees or other individuals.", "In the past, individual employees were sometimes responsible for managing and protecting their data.", "A patchwork of hardware and software point solutions have been applied in other cases.", "These solutions were often provided by different vendors and had limited or no interoperability.", "Certain embodiments described herein provide systems and methods capable of addressing these and other shortcomings of prior approaches by implementing unified, organization-wide information management.", "FIG.", "1A shows one such information management system 100, which generally includes combinations of hardware and software configured to protect and manage data and metadata generated and used by the various computing devices in the information management system 100.The organization which employs the information management system 100 may be a corporation or other business entity, non-profit organization, educational institution, household, governmental agency, or the like.", "Generally, the systems and associated components described herein may be compatible with and/or provide some or all of the functionality of the systems and corresponding components described in one or more of the following U.S. patents and patent application publications assigned to CommVault Systems, Inc., each of which is hereby incorporated in its entirety by reference herein: U.S. Pat.", "Pub.", "No.", "2010-0332456, entitled “DATA OBJECT STORE AND SERVER FOR A CLOUD STORAGE ENVIRONMENT, INCLUDING DATA DEDUPLICATION AND DATA MANAGEMENT ACROSS MULTIPLE CLOUD STORAGE SITES”; U.S. Pat.", "No.", "7,035,880, entitled “MODULAR BACKUP AND RETRIEVAL SYSTEM USED IN CONJUNCTION WITH A STORAGE AREA NETWORK”; U.S. Pat.", "No.", "7,343,453, entitled “HIERARCHICAL SYSTEMS AND METHODS FOR PROVIDING A UNIFIED VIEW OF STORAGE INFORMATION”; U.S. Pat.", "No.", "7,395,282, entitled “HIERARCHICAL BACKUP AND RETRIEVAL SYSTEM”; U.S. Pat.", "No.", "7,246,207, entitled “SYSTEM AND METHOD FOR DYNAMICALLY PERFORMING STORAGE OPERATIONS IN A COMPUTER NETWORK”; U.S. Pat.", "No.", "7,747,579, entitled “METABASE FOR FACILITATING DATA CLASSIFICATION”; U.S. Pat.", "No.", "8,229,954, entitled “MANAGING COPIES OF DATA”; U.S. Pat.", "No.", "7,617,262, entitled “SYSTEM AND METHODS FOR MONITORING APPLICATION DATA IN A DATA REPLICATION SYSTEM”; U.S. Pat.", "No.", "7,529,782, entitled “SYSTEM AND METHODS FOR PERFORMING A SNAPSHOT AND FOR RESTORING DATA”; U.S. Pat.", "No.", "8,230,195, entitled “SYSTEM AND METHOD FOR PERFORMING AUXILIARY STORAGE OPERATIONS”; U.S. Pat.", "Pub.", "No.", "2012/0084269, entitled “CONTENT-ALIGNED, BLOCK-BASED DEDUPLICATION”; U.S. Pat.", "Pub.", "No.", "2006/0224846, entitled “SYSTEM AND METHOD TO SUPPORT SINGLE INSTANCE STORAGE OPERATIONS”; U.S. Pat.", "Pub.", "No.", "2009/0329534, entitled “APPLICATION-AWARE AND REMOTE SINGLE INSTANCE DATA MANAGEMENT”; U.S. Pat.", "Pub.", "No.", "2012/0150826, entitled “DISTRIBUTED DEDUPLICATED STORAGE SYSTEM”; U.S. Pat.", "Pub.", "No.", "2012/0150818, entitled “CLIENT-SIDE REPOSITORY IN A NETWORKED DEDUPLICATED STORAGE SYSTEM”; U.S. Pat.", "No.", "8,170,995, entitled “METHOD AND SYSTEM FOR OFFLINE INDEXING OF CONTENT AND CLASSIFYING STORED DATA”; and U.S. Pat.", "No.", "8,156,086, entitled “SYSTEMS AND METHODS FOR STORED DATA VERIFICATION”.", "The illustrated information management system 100 includes one or more client computing device 102 having at least one application 110 executing thereon, and one or more primary storage devices 104 storing primary data 112.The client computing device(s) 102 and the primary storage devices 104 may generally be referred to in some cases as a primary storage subsystem 117.Depending on the context, the term “information management system” can refer to generally all of the illustrated hardware and software components.", "Or, in other instances, the term may refer to only a subset of the illustrated components.", "For instance, in some cases information management system 100 generally refers to a combination of specialized components used to protect, move, manage, manipulate and/or process data and metadata generated by the client computing devices 102.However, the term may generally not refer to the underlying components that generate and/or store the primary data 112, such as the client computing devices 102 themselves, the applications 110 and operating system residing on the client computing devices 102, and the primary storage devices 104.As an example, “information management system” may sometimes refer only to one or more of the following components and corresponding data structures: storage managers, data agents, and media agents.", "These components will be described in further detail below.", "Client Computing Devices There are typically a variety of sources in an organization that produce data to be protected and managed.", "As just one illustrative example, in a corporate environment such data sources can be employee workstations and company servers such as a mail server, a web server, or the like.", "In the information management system 100, the data generation sources include the one or more client computing devices 102.The client computing devices 102 may include, without limitation, one or more: workstations, personal computers, desktop computers, or other types of generally fixed computing systems such as mainframe computers and minicomputers.", "The client computing devices 102 can also include mobile or portable computing devices, such as one or more laptops, tablet computers, personal data assistants, mobile phones (such as smartphones), and other mobile or portable computing devices such as embedded computers, set top boxes, vehicle-mounted devices, wearable computers, etc.", "In some cases, each client computing device 102 is associated with one or more users and/or corresponding user accounts, of employees or other individuals.", "The term “client computing device” is used herein because the information management system 100 generally “serves” the data management and protection needs for the data generated by the client computing devices 102.However, the use of this term does not imply that the client computing devices 102 cannot be “servers” in other respects.", "For instance, a particular client computing device 102 may act as a server with respect to other devices, such as other client computing devices 102.As just a few examples, the client computing devices 102 can include mail servers, file servers, database servers, and web servers.", "The client computing devices 102 may additionally include virtualized and/or cloud computing resources.", "For instance, one or more virtual machines may be provided to the organization by a third-party cloud service vendor.", "Or, in some embodiments, the client computing devices 102 include one or more virtual machine(s) running on a virtual machine host computing device operated by the organization.", "As one example, the organization may use one virtual machine as a database server and another virtual machine as a mail server.", "A virtual machine manager (VMM) (e.g., a Hypervisor) may manage the virtual machines, and reside and execute on the virtual machine host computing device.", "Each client computing device 102 may have one or more applications 110 (e.g., software applications) executing thereon which generate and manipulate the data that is to be protected from loss.", "The applications 110 generally facilitate the operations of an organization (or multiple affiliated organizations), and can include, without limitation, mail server applications (e.g., Microsoft Exchange Server), file server applications, mail client applications (e.g., Microsoft Exchange Client), database applications (e.g., SQL, Oracle, SAP, Lotus Notes Database), word processing applications (e.g., Microsoft Word), spreadsheet applications, financial applications, presentation applications, browser applications, mobile applications, entertainment applications, and so on.", "The applications 110 can include at least one operating system (e.g., Microsoft Windows, Mac OS X, iOS, IBM z/OS, Linux, other Unix-based operating systems, etc.", "), which may support one or more file systems and host the other applications 110.As shown, the client computing devices 102 and other components in the information management system 100 can be connected to one another via one or more communication pathways 114.The communication pathways 114 can include one or more networks or other connection types including as any of following, without limitation: the Internet, a wide area network (WAN), a local area network (LAN), a Storage Area Network (SAN), a Fibre Channel connection, a Small Computer System Interface (SCSI) connection, a virtual private network (VPN), a token ring or TCP/IP based network, an intranet network, a point-to-point link, a cellular network, a wireless data transmission system, a two-way cable system, an interactive kiosk network, a satellite network, a broadband network, a baseband network, other appropriate wired, wireless, or partially wired/wireless computer or telecommunications networks, combinations of the same or the like.", "The communication pathways 114 in some cases may also include application programming interfaces (APIs) including, e.g., cloud service provider APIs, virtual machine management APIs, and hosted service provider APIs.", "Primary Data and Exemplary Primary Storage Devices Primary data 112 according to some embodiments is production data or other “live” data generated by the operating system and other applications 110 residing on a client computing device 102.The primary data 112 is stored on the primary storage device(s) 104 and is organized via a file system supported by the client computing device 102.For instance, the client computing device(s) 102 and corresponding applications 110 may create, access, modify, write, delete, and otherwise use primary data 112.Primary data 112 is generally in the native format of the source application 110.According to certain aspects, primary data 112 is an initial or first (e.g., created before any other copies or before at least one other copy) stored copy of data generated by the source application 110.Primary data 112 in some cases is created substantially directly from data generated by the corresponding source applications 110.The primary data 112 may sometimes be referred to as a “primary copy” in the sense that it is a discrete set of data.", "However, the use of this term does not necessarily imply that the “primary copy” is a copy in the sense that it was copied or otherwise derived from another stored version.", "The primary storage devices 104 storing the primary data 112 may be relatively fast and/or expensive (e.g., a disk drive, a hard-disk array, solid state memory, etc.).", "In addition, primary data 112 may be intended for relatively short term retention (e.g., several hours, days, or weeks).", "According to some embodiments, the client computing device 102 can access primary data 112 from the primary storage device 104 by making conventional file system calls via the operating system.", "Primary data 112 representing files may include structured data (e.g., database files), unstructured data (e.g., documents), and/or semi-structured data.", "Some specific examples are described below with respect to FIG.", "1B.", "It can be useful in performing certain tasks to break the primary data 112 up into units of different granularities.", "In general, primary data 112 can include files, directories, file system volumes, data blocks, extents, or any other types or granularities of data objects.", "As used herein, a “data object” can refer to both (1) any file that is currently addressable by a file system or that was previously addressable by the file system (e.g., an archive file) and (2) a subset of such a file.", "As will be described in further detail, it can also be useful in performing certain functions of the information management system 100 to access and modify metadata within the primary data 112.Metadata generally includes information about data objects or characteristics associated with the data objects.", "Metadata can include, without limitation, one or more of the following: the data owner (e.g., the client or user that generates the data), the last modified time (e.g., the time of the most recent modification of the data object), a data object name (e.g., a file name), a data object size (e.g., a number of bytes of data), information about the content (e.g., an indication as to the existence of a particular search term), to/from information for email (e.g., an email sender, recipient, etc.", "), creation date, file type (e.g., format or application type), last accessed time, application type (e.g., type of application that generated the data object), location/network (e.g., a current, past or future location of the data object and network pathways to/from the data object), frequency of change (e.g., a period in which the data object is modified), business unit (e.g., a group or department that generates, manages or is otherwise associated with the data object), and aging information (e.g., a schedule, such as a time period, in which the data object is migrated to secondary or long term storage), boot sectors, partition layouts, file location within a file folder directory structure, user permissions, owners, groups, access control lists [ACLs]), system metadata (e.g., registry information), combinations of the same or the like.", "In addition to metadata generated by or related to file systems and operating systems, some of the applications 110 maintain indices of metadata for data objects, e.g., metadata associated with individual email messages.", "Thus, each data object may be associated with corresponding metadata.", "The use of metadata to perform classification and other functions is described in greater detail below.", "Each of the client computing devices 102 are associated with and/or in communication with one or more of the primary storage devices 104 storing corresponding primary data 112.A client computing device 102 may be considered to be “associated with” or “in communication with” a primary storage device 104 if it is capable of one or more of: storing data to the primary storage device 104, retrieving data from the primary storage device 104, and modifying data retrieved from a primary storage device 104.The primary storage devices 104 can include, without limitation, disk drives, hard-disk arrays, semiconductor memory (e.g., solid state drives), and network attached storage (NAS) devices.", "In some cases, the primary storage devices 104 form part of a distributed file system.", "The primary storage devices 104 may have relatively fast I/O times and/or are relatively expensive in comparison to the secondary storage devices 108.For example, the information management system 100 may generally regularly access data and metadata stored on primary storage devices 104, whereas data and metadata stored on the secondary storage devices 108 is accessed relatively less frequently.", "In some cases, each primary storage device 104 is dedicated to an associated client computing devices 102.For instance, a primary storage device 104 in one embodiment is a local disk drive of a corresponding client computing device 102.In other cases, one or more primary storage devices 104 can be shared by multiple client computing devices 102.As one example, a primary storage device 104 can be a disk array shared by a group of client computing devices 102, such as one of the following types of disk arrays: EMC Clariion, EMC Symmetrix, EMC Celerra, Dell EqualLogic, IBM XIV, NetApp FAS, HP EVA, and HP 3PAR.", "The information management system 100 may also include hosted services (not shown), which may be hosted in some cases by an entity other than the organization that employs the other components of the information management system 100.For instance, the hosted services may be provided by various online service providers to the organization.", "Such service providers can provide services including social networking services, hosted email services, or hosted productivity applications or other hosted applications).", "Hosted services may include software-as-a-service (SaaS), platform-as-a-service (PaaS), application service providers (ASPs), cloud services, or other mechanisms for delivering functionality via a network.", "As it provides services to users, each hosted service may generate additional data and metadata under management of the information management system 100, e.g., as primary data 112.In some cases, the hosted services may be accessed using one of the applications 110.As an example, a hosted mail service may be accessed via browser running on a client computing device 102.Secondary Copies and Exemplary Secondary Storage Devices The primary data 112 stored on the primary storage devices 104 may be compromised in some cases, such as when an employee deliberately or accidentally deletes or overwrites primary data 112 during their normal course of work.", "Or the primary storage devices 104 can be damaged or otherwise corrupted.", "For recovery and/or regulatory compliance purposes, it is therefore useful to generate copies of the primary data 112.Accordingly, the information management system 100 includes one or more secondary storage computing devices 106 and one or more secondary storage devices 108 configured to create and store one or more secondary copies 116 of the primary data 112 and associated metadata.", "The secondary storage computing devices 106 and the secondary storage devices 108 may be referred to in some cases as a secondary storage subsystem 118.Creation of secondary copies 116 can help meet information management goals, such as: restoring data and/or metadata if an original version (e.g., of primary data 112) is lost (e.g., by deletion, corruption, or disaster); allowing point-in-time recovery; complying with regulatory data retention and electronic discovery (e-discovery) requirements; reducing utilized storage capacity; facilitating organization and search of data; improving user access to data files across multiple computing devices and/or hosted services; and implementing data retention policies.", "Types of secondary copy operations can include, without limitation, backup operations, archive operations, snapshot operations, replication operations (e.g., continuous data replication [CDR]), data retention policies such as information lifecycle management and hierarchical storage management operations, and the like.", "These specific types operations are discussed in greater detail below.", "Regardless of the type of secondary copy operation, the client computing devices 102 access or receive primary data 112 and communicate the data, e.g., over the communication pathways 114, for storage in the secondary storage device(s) 108.A secondary copy 116 can comprise a separate stored copy of application data that is derived from one or more earlier created, stored copies (e.g., derived from primary data 112 or another secondary copy 116).", "Secondary copies 116 can include point-in-time data, and may be intended for relatively long-term retention (e.g., weeks, months or years), before some or all of the data is moved to other storage or is discarded.", "In some cases, a secondary copy 116 is a copy of application data created and stored subsequent to at least one other stored instance (e.g., subsequent to corresponding primary data 112 or to another secondary copy 116), in a different storage device than at least one previous stored copy, and/or remotely from at least one previous stored copy.", "Secondary copies 116 may be stored in relatively slow and/or low cost storage (e.g., magnetic tape).", "A secondary copy 116 may be stored in a backup or archive format, or in some other format different than the native source application format or other primary data format.", "In some cases, secondary copies 116 are indexed so users can browse and restore at another point in time.", "After creation of a secondary copy 116 representative of certain primary data 112, a pointer or other location indicia (e.g., a stub) may be placed in primary data 112, or be otherwise associated with primary data 112 to indicate the current location on the secondary storage device(s) 108.Since an instance a data object or metadata in primary data 112 may change over time as it is modified by an application 110 (or hosted service or the operating system), the information management system 100 may create and manage multiple secondary copies 116 of a particular data object or metadata, each representing the state of the data object in primary data 112 at a particular point in time.", "Moreover, since an instance of a data object in primary data 112 may eventually be deleted from the primary storage device 104 and the file system, the information management system 100 may continue to manage point-in-time representations of that data object, even though the instance in primary data 112 no longer exists.", "For virtualized computing devices the operating system and other applications 110 of the client computing device(s) 102 may execute within or under the management of virtualization software (e.g., a VMM), and the primary storage device(s) 104 may comprise a virtual disk created on a physical storage device.", "The information management system 100 may create secondary copies 116 of the files or other data objects in a virtual disk file and/or secondary copies 116 of the entire virtual disk file itself (e.g., of an entire .vmdk file).", "Secondary copies 116 may be distinguished from corresponding primary data 112 in a variety of ways, some of which will now be described.", "First, as discussed, secondary copies 116 can be stored in a different format (e.g., backup, archive, or other non-native format) than primary data 112.For this or other reasons, secondary copies 116 may not be directly useable by the applications 110 of the client computing device 102, e.g., via standard system calls or otherwise without modification, processing, or other intervention by the information management system 100.Secondary copies 116 are also often stored on a secondary storage device 108 that is inaccessible to the applications 110 running on the client computing devices 102 (and/or hosted services).", "Some secondary copies 116 may be “offline copies,” in that they are not readily available (e.g.", "not mounted to tape or disk).", "Offline copies can include copies of data that the information management system 100 can access without human intervention (e.g.", "tapes within an automated tape library, but not yet mounted in a drive), and copies that the information management system 100 can access only with at least some human intervention (e.g.", "tapes located at an offsite storage site).", "The secondary storage devices 108 can include any suitable type of storage device such as, without limitation, one or more tape libraries, disk drives or other magnetic, non-tape storage devices, optical media storage devices, solid state storage devices, NAS devices, combinations of the same, and the like.", "In some cases, the secondary storage devices 108 are provided in a cloud (e.g.", "a private cloud or one operated by a third-party vendor).", "The secondary storage device(s) 108 in some cases comprises a disk array or a portion thereof.", "In some cases, a single storage device (e.g., a disk array) is used for storing both primary data 112 and at least some secondary copies 116.In one example, a disk array capable of performing hardware snapshots stores primary data 112 and creates and stores hardware snapshots of the primary data 112 as secondary copies 116.The Use of Intermediary Devices for Creating Secondary Copies Creating secondary copies can be a challenging task.", "For instance, there can be hundreds or thousands of client computing devices 102 continually generating large volumes of primary data 112 to be protected.", "Also, there can be significant overhead involved in the creation of secondary copies 116.Moreover, secondary storage devices 108 may be special purpose components, and interacting with them can require specialized intelligence.", "In some cases, the client computing devices 102 interact directly with the secondary storage device 108 to create the secondary copies 116.However, in view of the factors described above, this approach can negatively impact the ability of the client computing devices 102 to serve the applications 110 and produce primary data 112.Further, the client computing devices 102 may not be optimized for interaction with the secondary storage devices 108.Thus, in some embodiments, the information management system 100 includes one or more software and/or hardware components which generally act as intermediaries between the client computing devices 102 and the secondary storage devices 108.In addition to off-loading certain responsibilities from the client computing devices 102, these intermediary components can provide other benefits.", "For instance, as discussed further below with respect to FIG.", "1D, distributing some of the work involved in creating secondary copies 116 can enhance scalability.", "The intermediary components can include one or more secondary storage computing devices 106 as shown in FIG.", "1A and/or one or more media agents, which can be software modules residing on corresponding secondary storage computing devices 106 (or other appropriate devices).", "Media agents are discussed below (e.g., with respect to FIGS.", "1C-1E).", "The secondary storage computing device(s) 106 can comprise any appropriate type of computing device and can include, without limitation, any of the types of fixed and portable computing devices described above with respect to the client computing devices 102.In some cases, the secondary storage computing device(s) 106 include specialized hardware and/or software componentry for interacting with the secondary storage devices 108.To create a secondary copy 116, the client computing device 102 communicates the primary data 112 to be copied (or a processed version thereof) to the designated secondary storage computing device 106, via the communication pathway 114.The secondary storage computing device 106 in turn conveys the received data (or a processed version thereof) to the secondary storage device 108.In some such configurations, the communication pathway 114 between the client computing device 102 and the secondary storage computing device 106 comprises a portion of a LAN, WAN or SAN.", "In other cases, at least some client computing devices 102 communicate directly with the secondary storage devices 108 (e.g., via Fibre Channel or SCSI connections).", "Exemplary Primary Data and an Exemplary Secondary Copy FIG.", "1B is a detailed view showing some specific examples of primary data stored on the primary storage device(s) 104 and secondary copy data stored on the secondary storage device(s) 108, with other components in the system removed for the purposes of illustration.", "Stored on the primary storage device(s) 104 are primary data objects including word processing documents 119A-B, spreadsheets 120, presentation documents 122, video files 124, image files 126, email mailboxes 128 (and corresponding email messages 129A-C), html/xml or other types of markup language files 130, databases 132 and corresponding tables 133A-133C).", "Some or all primary data objects are associated with a primary copy of object metadata (e.g., “Meta1-11”), which may be file system metadata and/or application specific metadata.", "Stored on the secondary storage device(s) 108 are secondary copy objects 134A-C which may include copies of or otherwise represent corresponding primary data objects and metadata.", "As shown, the secondary copy objects 134A-C can individually represent more than one primary data object.", "For example, secondary copy data object 134A represents three separate primary data objects 133C, 122 and 129C (represented as 133C′, 122′ and 129C′, respectively).", "Moreover, as indicated by the prime mark (′), a secondary copy object may store a representation of a primary data object or metadata differently than the original format, e.g., in a compressed, encrypted, deduplicated, or other modified format.", "Exemplary Information Management System Architecture The information management system 100 can incorporate a variety of different hardware and software components, which can in turn be organized with respect to one another in many different configurations, depending on the embodiment.", "There are critical design choices involved in specifying the functional responsibilities of the components and the role of each component in the information management system 100.For instance, as will be discussed, such design choices can impact performance as well as the adaptability of the information management system 100 to data growth or other changing circumstances.", "FIG.", "1C shows an information management system 100 designed according to these considerations and which includes: a central storage or information manager 140 configured to perform certain control functions, one or more data agents 142 executing on the client computing device(s) 102 configured to process primary data 112, and one or more media agents 144 executing on the one or more secondary storage computing devices 106 for performing tasks involving the secondary storage devices 108.Storage Manager As noted, the number of components in the information management system 100 and the amount of data under management can be quite large.", "Managing the components and data is therefore a significant task, and a task that can grow in an often unpredictable fashion as the quantity of components and data scale to meet the needs of the organization.", "For these and other reasons, according to certain embodiments, responsibility for controlling the information management system 100, or at least a significant portion of that responsibility, is allocated to the storage manager 140.By distributing control functionality in this manner, the storage manager 140 can be adapted independently according to changing circumstances.", "Moreover, a host computing device can be selected to best suit the functions of the storage manager 140.These and other advantages are described in further detail below with respect to FIG.", "1D.", "The storage manager 140 may be a software module or other application.", "The storage manager generally initiates, coordinates and/or controls storage and other information management operations performed by the information management system 100, e.g., to protect and control the primary data 112 and secondary copies 116 of data and metadata.", "As shown by the dashed, arrowed lines, the storage manager 140 may communicate with and/or control some or all elements of the information management system 100, such as the data agents 142 and media agents 144.Thus, in certain embodiments, control information originates from the storage manager 140, whereas payload data and metadata is generally communicated between the data agents 142 and the media agents 144 (or otherwise between the client computing device(s) 102 and the secondary storage computing device(s) 106), e.g., at the direction of the storage manager 140.In other embodiments, some information management operations are controlled by other components in the information management system 100 (e.g., the media agent(s) 144 or data agent(s) 142), instead of or in combination with the storage manager 140.According to certain embodiments, the storage manager provides one or more of the following functions: initiating execution of secondary copy operations; managing secondary storage devices 108 and inventory/capacity of the same; allocating secondary storage devices 108 for secondary storage operations; monitoring completion of and providing status reporting related to secondary storage operations; tracking age information relating to secondary copies 116, secondary storage devices 108, and comparing the age information against retention guidelines; tracking movement of data within the information management system 100; tracking logical associations between components in the information management system 100; protecting metadata associated with the information management system 100; and implementing operations management functionality; The storage manager 140 may maintain a database 146 of management-related data and information management policies 148.The database 146 may include a management index 150 or other data structure that stores logical associations between components of the system, user preferences and/or profiles (e.g., preferences regarding encryption, compression, or deduplication of primary or secondary copy data, preferences regarding the scheduling, type, or other aspects of primary or secondary copy or other operations, mappings of particular information management users or user accounts to certain computing devices or other components, etc.", "), management tasks, media containerization, or other useful data.", "For example, the storage manager 140 may use the index 150 to track logical associations between media agents 144 and secondary storage devices 108 and/or movement of data from primary storage devices 104 to secondary storage devices 108.Administrators and other employees may be able to manually configure and initiate certain information management operations on an individual basis.", "But while this may be acceptable for some recovery operations or other relatively less frequent tasks, it is often not workable for implementing on-going organization-wide data protection and management.", "Thus, the information management system 100 may utilize information management policies 148 for specifying and executing information management operations (e.g., on an automated basis).", "Generally, an information management policy 148 can include a data structure or other information source that specifies a set of parameters (e.g., criteria and rules) associated with storage or other information management operations.", "The storage manager database 146 may maintain the information management policies 148 and associated data, although the information management policies 148 can be stored in any appropriate location.", "For instance, a storage policy may be stored as metadata in a media agent database 152 or in a secondary storage device 108 (e.g., as an archive copy) for use in restore operations or other information management operations, depending on the embodiment.", "Information management policies 148 are described further below.", "According to certain embodiments, the storage manager database 146 comprises a relational database (e.g., an SQL database) for tracking metadata, such as metadata associated with secondary copy operations (e.g., what client computing devices 102 and corresponding data were protected).", "This and other metadata may additionally be stored in other locations, such as at the secondary storage computing devices 106 or on the secondary storage devices 108, allowing data recovery without the use of the storage manager 140.As shown, the storage manager 140 may include a jobs agent 156, a user interface 158, and a management agent 154, all of which may be implemented as interconnected software modules or application programs.", "The jobs agent 156 in some embodiments initiates, controls, and/or monitors the status of some or all storage or other information management operations previously performed, currently being performed, or scheduled to be performed by the information management system 100.For instance, the jobs agent 156 may access information management policies 148 to determine when and how to initiate and control secondary copy and other information management operations, as will be discussed further.", "The user interface 158 may include information processing and display software, such as a graphical user interface (“GUI”), an application program interface (“API”), or other interactive interface through which users and system processes can retrieve information about the status of information management operations (e.g., storage operations) or issue instructions to the information management system 100 and its constituent components.", "The storage manager 140 may also track information that permits it to select, designate, or otherwise identify content indices, deduplication databases, or similar databases or resources or data sets within its information management cell (or another cell) to be searched in response to certain queries.", "Such queries may be entered by the user via interaction with the user interface 158.Via the user interface 158, users may optionally issue instructions to the components in the information management system 100 regarding performance of storage and recovery operations.", "For example, a user may modify a schedule concerning the number of pending secondary copy operations.", "As another example, a user may employ the GUI to view the status of pending storage operations or to monitor the status of certain components in the information management system 100 (e.g., the amount of capacity left in a storage device).", "In general, the management agent 154 allows multiple information management systems 100 to communicate with one another.", "For example, the information management system 100 in some cases may be one information management subsystem or “cell” of a network of multiple cells adjacent to one another or otherwise logically related in a WAN or LAN.", "With this arrangement, the cells may be connected to one another through respective management agents 154.For instance, the management agent 154 can provide the storage manager 140 with the ability to communicate with other components within the information management system 100 (and/or other cells within a larger information management system) via network protocols and application programming interfaces (“APIs”) including, e.g., HTTP, HTTPS, FTP, REST, virtualization software APIs, cloud service provider APIs, and hosted service provider APIs.", "Inter-cell communication and hierarchy is described in greater detail in U.S. Pat.", "No.", "7,035,880, which is incorporated by reference herein.", "Data Agents As discussed, a variety of different types of applications 110 can reside on a given client computing device 102, including operating systems, database applications, e-mail applications, and virtual machines, just to name a few.", "And, as part of the as part of the process of creating and restoring secondary copies 116, the client computing devices 102 may be tasked with processing and preparing the primary data 112 from these various different applications 110.Moreover, the nature of the processing/preparation can differ across clients and application types, e.g., due to inherent structural and formatting differences between applications 110.The one or more data agent(s) 142 are therefore advantageously configured in some embodiments to assist in the performance of information management operations based on the type of data that is being protected, at a client-specific and/or application-specific level.", "The data agent 142 may be a software module or component that is generally responsible for managing, initiating, or otherwise assisting in the performance of information management operations.", "For instance, the data agent 142 may take part in performing data storage operations such as the copying, archiving, migrating, replicating of primary data 112 stored in the primary storage device(s) 104.The data agent 142 may receive control information from the storage manager 140, such as commands to transfer copies of data objects, metadata, and other payload data to the media agents 144.In some embodiments, a data agent 142 may be distributed between the client computing device 102 and storage manager 140 (and any other intermediate components) or may be deployed from a remote location or its functions approximated by a remote process that performs some or all of the functions of data agent 142.In addition, a data agent 142 may perform some functions provided by a media agent 144, e.g., encryption and deduplication.", "As indicated, each data agent 142 may be specialized for a particular application 110, and the system can employ multiple data agents 142, each of which may backup, migrate, and recover data associated with a different application 110.For instance, different individual data agents 142 may be designed to handle Microsoft Exchange data, Lotus Notes data, Microsoft Windows file system data, Microsoft Active Directory Objects data, SQL Server data, SharePoint data, Oracle database data, SAP database data, virtual machines and/or associated data, and other types of data.", "A file system data agent, for example, may handle data files and/or other file system information.", "If a client computing device 102 has two or more types of data, one data agent 142 may be used for each data type to copy, archive, migrate, and restore the client computing device 102 data.", "For example, to backup, migrate, and restore all of the data on a Microsoft Exchange server, the client computing device 102 may use one Microsoft Exchange Mailbox data agent 142 to backup the Exchange mailboxes, one Microsoft Exchange Database data agent 142 to backup the Exchange databases, one Microsoft Exchange Public Folder data agent 142 to backup the Exchange Public Folders, and one Microsoft Windows File System data agent 142 to backup the file system of the client computing device 102.In such embodiments, these data agents 142 may be treated as four separate data agents 142 even though they reside on the same client computing device 102.Other embodiments may employ one or more generic data agents 142 that can handle and process data from two or more different applications 110, or that can handle and process multiple data types, instead of or in addition to using specialized data agents 142.For example, one generic data agent 142 may be used to back up, migrate and restore Microsoft Exchange Mailbox data and Microsoft Exchange Database data while another generic data agent may handle Microsoft Exchange Public Folder data and Microsoft Windows File System data.", "Each data agent 142 may be configured to access data and/or metadata stored in the primary storage device(s) 104 associated with the data agent 142 and process the data as appropriate.", "For example, during a secondary copy operation, the data agent 142 may arrange or assemble the data and metadata into one or more files having a certain format (e.g., a particular backup or archive format) before transferring the file(s) to a media agent 144 or other component.", "The file(s) may include a list of files or other metadata.", "Each data agent 142 can also assist in restoring data or metadata to primary storage devices 104 from a secondary copy 116.For instance, the data agent 142 may operate in conjunction with the storage manager 140 and one or more of the media agents 144 to restore data from secondary storage device(s) 108.Media Agents As indicated above with respect to FIG.", "1A, off-loading certain responsibilities from the client computing devices 102 to intermediary components such as the media agent(s) 144 can provide a number of benefits including improved client computing device 102 operation, faster secondary copy operation performance, and enhanced scalability.", "As one specific example which will be discussed below in further detail, the media agent 144 can act as a local cache of copied data and/or metadata that it has stored to the secondary storage device(s) 108, providing improved restore capabilities.", "Generally speaking, a media agent 144 may be implemented as a software module that manages, coordinates, and facilitates the transmission of data, as directed by the storage manager 140, between a client computing device 102 and one or more secondary storage devices 108.Whereas the storage manager 140 controls the operation of the information management system 100, the media agent 144 generally provides a portal to secondary storage devices 108.Media agents 144 can comprise logically and/or physically separate nodes in the information management system 100 (e.g., separate from the client computing devices 102, storage manager 140, and/or secondary storage devices 108).", "In addition, each media agent 144 may reside on a dedicated secondary storage computing device 106 in some cases, while in other embodiments a plurality of media agents 144 reside on the same secondary storage computing device 106.A media agent 144 (and corresponding media agent database 152) may be considered to be “associated with” a particular secondary storage device 108 if that media agent 144 is capable of one or more of: routing and/or storing data to the particular secondary storage device 108, coordinating the routing and/or storing of data to the particular secondary storage device 108, retrieving data from the particular secondary storage device 108, and coordinating the retrieval of data from a particular secondary storage device 108.While media agent(s) 144 are generally associated with one or more secondary storage devices 108, the media agents 144 in certain embodiments are physically separate from the secondary storage devices 108.For instance, the media agents 144 may reside on secondary storage computing devices 106 having different housings or packages than the secondary storage devices 108.In one example, a media agent 144 resides on a first server computer and is in communication with a secondary storage device(s) 108 residing in a separate, rack-mounted RAID-based system.", "In operation, a media agent 144 associated with a particular secondary storage device 108 may instruct the secondary storage device 108 (e.g., a tape library) to use a robotic arm or other retrieval means to load or eject a certain storage media, and to subsequently archive, migrate, or retrieve data to or from that media, e.g., for the purpose of restoring the data to a client computing device 102.The media agent 144 may communicate with a secondary storage device 108 via a suitable communications link, such as a SCSI or Fiber Channel link.", "As shown, each media agent 144 may maintain an associated media agent database 152.The media agent database 152 may be stored in a disk or other storage device (not shown) that is local to the secondary storage computing device 106 on which the media agent 144 resides.", "In other cases, the media agent database 152 is stored remotely from the secondary storage computing device 106.The media agent database 152 can include, among other things, an index 153 including data generated during secondary copy operations and other storage or information management operations.", "The index 153 provides a media agent 144 or other component with a fast and efficient mechanism for locating secondary copies 116 or other data stored in the secondary storage devices 108.In one configuration, a storage manager index 150 or other data structure may store data associating a client computing device 102 with a particular media agent 144 and/or secondary storage device 108, as specified in a storage policy.", "A media agent index 153 or other data structure associated with the particular media agent 144 may in turn include information about the stored data.", "For instance, for each secondary copy 116, the index 153 may include metadata such as a list of the data objects (e.g., files/subdirectories, database objects, mailbox objects, etc.", "), a path to the secondary copy 116 on the corresponding secondary storage device 108, location information indicating where the data objects are stored in the secondary storage device 108, when the data objects were created or modified, etc.", "Thus, the index 153 includes metadata associated with the secondary copies 116 that is readily available for use in storage operations and other activities without having to be first retrieved from the secondary storage device 108.In yet further embodiments, some or all of the data in the index 153 may instead or additionally be stored along with the data in a secondary storage device 108, e.g., with a copy of the index 153.Because the index 153 maintained in the database 152 may operate as a cache, it can also be referred to as an index cache.", "In such cases, information stored in the index cache 153 typically comprises data that reflects certain particulars about storage operations that have occurred relatively recently.", "After some triggering event, such as after a certain period of time elapses, or the index cache 153 reaches a particular size, the index cache 153 may be copied or migrated to a secondary storage device(s) 108.This information may need to be retrieved and uploaded back into the index cache 153 or otherwise restored to a media agent 144 to facilitate retrieval of data from the secondary storage device(s) 108.In some embodiments, the cached information may include format or containerization information related to archives or other files stored on the storage device(s) 108.In this manner, the index cache 153 allows for accelerated restores.", "In some alternative embodiments the media agent 144 generally acts as a coordinator or facilitator of storage operations between client computing devices 102 and corresponding secondary storage devices 108, but does not actually write the data to the secondary storage device 108.For instance, the storage manager 140 (or the media agent 144) may instruct a client computing device 102 and secondary storage device 108 to communicate with one another directly.", "In such a case the client computing device 102 transmits the data directly to the secondary storage device 108 according to the received instructions, and vice versa.", "In some such cases, the media agent 144 may still receive, process, and/or maintain metadata related to the storage operations.", "Moreover, in these embodiments, the payload data can flow through the media agent 144 for the purposes of populating the index cache 153 maintained in the media agent database 152, but not for writing to the secondary storage device 108.The media agent 144 and/or other components such as the storage manager 140 may in some cases incorporate additional functionality, such as data classification, content indexing, deduplication, encryption, compression, and the like.", "Further details regarding these and other functions are described below.", "Distributed, Scalable Architecture As described, certain functions of the information management system 100 can be distributed amongst various physical and/or logical components in the system.", "For instance, one or more of the storage manager 140, data agents 142, and media agents 144 may reside on computing devices that are physically separate from one another.", "This architecture can provide a number of benefits.", "For instance, hardware and software design choices for each distributed component can be targeted to suit its particular function.", "The secondary computing devices 106 on which the media agents 144 reside can be tailored for interaction with associated secondary storage devices 108 and provide fast index cache operation, among other specific tasks.", "Similarly, the client computing device(s) 102 can be selected to effectively service the applications 110 residing thereon, in order to efficiently produce and store primary data 112.Moreover, in some cases, one or more of the individual components in the information management system 100 can be distributed to multiple, separate computing devices.", "As one example, for large file systems where the amount of data stored in the storage management database 146 is relatively large, the management database 146 may be migrated to or otherwise reside on a specialized database server (e.g., an SQL server) separate from a server that implements the other functions of the storage manager 140.This configuration can provide added protection because the database 146 can be protected with standard database utilities (e.g., SQL log shipping or database replication) independent from other functions of the storage manager 140.The database 146 can be efficiently replicated to a remote site for use in the event of a disaster or other data loss incident at the primary site.", "Or the database 146 can be replicated to another computing device within the same site, such as to a higher performance machine in the event that a storage manager host device can no longer service the needs of a growing information management system 100.The distributed architecture also provides both scalability and efficient component utilization.", "FIG.", "1D shows an embodiment of the information management system 100 including a plurality of client computing devices 102 and associated data agents 142 as well as a plurality of secondary storage computing devices 106 and associated media agents 144.Additional components can be added or subtracted based on the evolving needs of the information management system 100.For instance, depending on where bottlenecks are identified, administrators can add additional client computing devices 102, secondary storage devices 106 (and corresponding media agents 144), and/or secondary storage devices 108.Moreover, each client computing device 102 in some embodiments can communicate with any of the media agents 144, e.g., as directed by the storage manager 140.And each media agent 144 may be able to communicate with any of the secondary storage devices 108, e.g., as directed by the storage manager 140.Thus, operations can be routed to the secondary storage devices 108 in a dynamic and highly flexible manner.", "Further examples of scalable systems capable of dynamic storage operations are provided in U.S. Pat.", "No.", "7,246,207, which is incorporated by reference herein.", "In alternative configurations, certain components are not distributed and may instead reside and execute on the same computing device.", "For example, in some embodiments one or more data agents 142 and the storage manager 140 reside on the same client computing device 102.In another embodiment, one or more data agents 142 and one or more media agents 144 reside on a single computing device.", "Exemplary Types of Information Management Operations In order to protect and leverage stored data, the information management system 100 can be configured to perform a variety of information management operations.", "As will be described, these operations can generally include secondary copy and other data movement operations, processing and data manipulation operations, and management operations.", "Data Movement Operations Data movement operations according to certain embodiments are generally operations that involve the copying or migration of data (e.g., payload data) between different locations in the information management system 100.For example, data movement operations can include operations in which stored data is copied, migrated, or otherwise transferred from primary storage device(s) 104 to secondary storage device(s) 108, from secondary storage device(s) 108 to different secondary storage device(s) 108, or from primary storage device(s) 104 to different primary storage device(s) 104.Data movement operations can include by way of example, backup operations, archive operations, information lifecycle management operations such as hierarchical storage management operations, replication operations (e.g., continuous data replication operations), snapshot operations, deduplication operations, single-instancing operations, auxiliary copy operations, and the like.", "As will be discussed, some of these operations involve the copying, migration or other movement of data, without actually creating multiple, distinct copies.", "Nonetheless, some or all of these operations are referred to as “copy” operations for simplicity.", "Backup Operations A backup operation creates a copy of primary data 112 at a particular point in time.", "Each subsequent backup copy may be maintained independently of the first.", "Further, a backup copy in some embodiments is stored in a backup format.", "This can be in contrast to the version in primary data 112 from which the backup copy is derived, and which may instead be stored in a native format of the source application(s) 110.In various cases, backup copies can be stored in a format in which the data is compressed, encrypted, deduplicated, and/or otherwise modified from the original application format.", "For example, a backup copy may be stored in a backup format that facilitates compression and/or efficient long-term storage.", "Backup copies can have relatively long retention periods as compared to primary data 112, and may be stored on media with slower retrieval times than primary data 112 and certain other types of secondary copies 116.On the other hand, backups may have relatively shorter retention periods than some other types of secondary copies 116, such as archive copies (described below).", "Backups may sometimes be stored at on offsite location.", "Backup operations can include full, synthetic or incremental backups.", "A full backup in some embodiments is generally a complete image of the data to be protected.", "However, because full backup copies can consume a relatively large amount of storage, it can be useful to use a full backup copy as a baseline and only store changes relative to the full backup copy for subsequent backup copies.", "For instance, a differential backup operation (or cumulative incremental backup operation) tracks and stores changes that have occurred since the last full backup.", "Differential backups can grow quickly in size, but can provide relatively efficient restore times because a restore can be completed in some cases using only the full backup copy and the latest differential copy.", "An incremental backup operation generally tracks and stores changes since the most recent backup copy of any type, which can greatly reduce storage utilization.", "In some cases, however, restore times can be relatively long in comparison to full or differential backups because completing a restore operation may involve accessing a full backup in addition to multiple incremental backups.", "Any of the above types of backup operations can be at the file-level, e.g., where the information management system 100 generally tracks changes to files at the file-level, and includes copies of files in the backup copy.", "In other cases, block-level backups are employed, where files are broken into constituent blocks, and changes are tracked at the block-level.", "Upon restore, the information management system 100 reassembles the blocks into files in a transparent fashion.", "Far less data may actually be transferred and copied to the secondary storage devices 108 during a block-level copy than during a file-level copy, resulting in faster execution times.", "However, when restoring a block-level copy, the process of locating constituent blocks can sometimes result in longer restore times as compared to file-level backups.", "Similar to backup operations, the other types of secondary copy operations described herein can also be implemented at either the file-level or the block-level.", "Archive Operations Because backup operations generally involve maintaining a version of the copied data in primary data 112 and also maintaining backup copies in secondary storage device(s) 108, they can consume significant storage capacity.", "To help reduce storage consumption, an archive operation according to certain embodiments creates a secondary copy 116 by both copying and removing source data.", "Or, seen another way, archive operations can involve moving some or all of the source data to the archive destination.", "Thus, data satisfying criteria for removal (e.g., data of a threshold age or size) from the source copy may be removed from source storage.", "Archive copies are sometimes stored in an archive format or other non-native application format.", "The source data may be primary data 112 or a secondary copy 116, depending on the situation.", "As with backup copies, archive copies can be stored in a format in which the data is compressed, encrypted, deduplicated, and/or otherwise modified from the original application format.", "In addition, archive copies may be retained for relatively long periods of time (e.g., years) and, in some cases, are never deleted.", "Archive copies are generally retained for longer periods of time than backup copies, for example.", "In certain embodiments, archive copies may be made and kept for extended periods in order to meet compliance regulations.", "Moreover, when primary data 112 is archived, in some cases the archived primary data 112 or a portion thereof is deleted when creating the archive copy.", "Thus, archiving can serve the purpose of freeing up space in the primary storage device(s) 104.Similarly, when a secondary copy 116 is archived, the secondary copy 116 may be deleted, and an archive copy can therefore serve the purpose of freeing up space in secondary storage device(s) 108.In contrast, source copies often remain intact when creating backup copies.", "Snapshot Operations Snapshot operations can provide a relatively lightweight, efficient mechanism for protecting data.", "From an end-user viewpoint, a snapshot may be thought of as an “instant” image of the primary data 112 at a given point in time.", "In one embodiment, a snapshot may generally capture the directory structure of an object in primary data 112 such as a file or volume or other data set at a particular moment in time and may also preserve file attributes and contents.", "A snapshot in some cases is created relatively quickly, e.g., substantially instantly, using a minimum amount of file space, but may still function as a conventional file system backup.", "A snapshot copy in many cases can be made quickly and without significantly impacting primary computing resources because large amounts of data need not be copied or moved.", "In some embodiments, a snapshot may exist as a virtual file system, parallel to the actual file system.", "Users in some cases gain read-only access to the record of files and directories of the snapshot.", "By electing to restore primary data 112 from a snapshot taken at a given point in time, users may also return the current file system to the state of the file system that existed when the snapshot was taken.", "Some types of snapshots do not actually create another physical copy of all the data as it existed at the particular point in time, but may simply create pointers that are able to map files and directories to specific memory locations (e.g., disk blocks) where the data resides, as it existed at the particular point in time.", "For example, a snapshot copy may include a set of pointers derived from the file system or an application.", "Each pointer points to a respective stored data block, so collectively, the set of pointers reflect the storage location and state of the data object (e.g., file(s) or volume(s) or data set(s)) at a particular point in time when the snapshot copy was created.", "In some embodiments, once a snapshot has been taken, subsequent changes to the file system typically do not overwrite the blocks in use at the time of the snapshot.", "Therefore, the initial snapshot may use only a small amount of disk space needed to record a mapping or other data structure representing or otherwise tracking the blocks that correspond to the current state of the file system.", "Additional disk space is usually required only when files and directories are actually modified later.", "Furthermore, when files are modified, typically only the pointers which map to blocks are copied, not the blocks themselves.", "In some embodiments, for example in the case of “copy-on-write” snapshots, when a block changes in primary storage, the block is copied to secondary storage or cached in primary storage before the block is overwritten in primary storage.", "The snapshot mapping of file system data is also updated to reflect the changed block(s) at that particular point in time.", "In some other cases, a snapshot includes a full physical copy of all or substantially all of the data represented by the snapshot.", "Further examples of snapshot operations are provided in U.S. Pat.", "No.", "7,529,782, which is incorporated by reference herein.", "Replication Operations Another type of secondary copy operation is a replication operation.", "Some types of secondary copies 116 are used to periodically capture images of primary data 112 at particular points in time (e.g., backups, archives, and snapshots).", "However, it can also be useful for recovery purposes to protect primary data 112 in a more continuous fashion, by replicating the primary data 112 substantially as changes occur.", "In some cases a replication copy can be a mirror copy, for instance, where changes made to primary data 112 are mirrored to another location (e.g., to secondary storage device(s) 108).", "By copying each write operation to the replication copy, two storage systems are kept synchronized or substantially synchronized so that they are virtually identical at approximately the same time.", "Where entire disk volumes are mirrored, however, mirroring can require significant amount of storage space and utilizes a large amount of processing resources.", "According to some embodiments storage operations are performed on replicated data that represents a recoverable state, or “known good state” of a particular application running on the source system.", "For instance, in certain embodiments, known good replication copies may be viewed as copies of primary data 112.This feature allows the system to directly access, copy, restore, backup or otherwise manipulate the replication copies as if the data was the “live”, primary data 112.This can reduce access time, storage utilization, and impact on source applications 110, among other benefits.", "Based on known good state information, the information management system 100 can replicate sections of application data that represent a recoverable state rather than rote copying of blocks of data.", "Examples of compatible replication operations (e.g., continuous data replication) are provided in U.S. Pat.", "No.", "7,617,262, which is incorporated by reference herein.", "Deduplication/Single-Instancing Operations Another type of data movement operation is deduplication, which is useful to reduce the amount of data within the system.", "For instance, some or all of the above-described secondary storage operations can involve deduplication in some fashion.", "New data is read, broken down into blocks (e.g., sub-file level blocks) of a selected granularity, compared with blocks that are already stored, and only the new blocks are stored.", "Blocks that already exist are represented as pointers to the already stored data.", "In order to stream-line the comparison process, the information management system 100 may calculate and/or store signatures (e.g., hashes) corresponding to the individual data blocks and compare the hashes instead of comparing entire data blocks.", "In some cases, only a single instance of each element is stored, and deduplication operations may therefore be referred to interchangeably as “single-instancing” operations.", "Depending on the implementation, however, deduplication or single-instancing operations can store more than one instance of certain data blocks, but nonetheless significantly reduce data redundancy.", "Moreover, single-instancing in some cases is distinguished from deduplication as a process of analyzing and reducing data at the file level, rather than the sub-file level.", "Depending on the embodiment, deduplication blocks can be of fixed or variable length.", "Using variable length blocks can provide enhanced deduplication by responding to changes in the data stream, but can involve complex processing.", "In some cases, the information management system 100 utilizes a technique for dynamically aligning deduplication blocks (e.g., fixed-length blocks) based on changing content in the data stream, as described in U.S. Pat.", "Pub.", "No.", "2012/0084269, which is incorporated by reference herein.", "The information management system 100 can perform deduplication in a variety of manners at a variety of locations in the information management system 100.For instance, in some embodiments, the information management system 100 implements “target-side” deduplication by deduplicating data (e.g., secondary copies 116) stored in the secondary storage devices 108.In some such cases, the media agents 144 are generally configured to manage the deduplication process.", "For instance, one or more of the media agents 144 maintain a corresponding deduplication database that stores deduplication information (e.g., datablock signatures).", "Examples of such a configuration are provided in U.S. Pat.", "Pub.", "No.", "2012/0150826, which is incorporated by reference herein.", "Deduplication can also be performed on the “source-side” (or “client-side”), e.g., to reduce the amount of traffic between the media agents 144 and the client computing device(s) 102 and/or reduce redundant data stored in the primary storage devices 104.Examples of such deduplication techniques are provided in U.S. Pat.", "Pub.", "No.", "2012/0150818, which is incorporated by reference herein.", "Information Lifecycle Management and Hierarchical Storage Management Operations In some embodiments, files and other data over their lifetime move from more expensive, quick access storage to less expensive, slower access storage.", "Operations associated with moving data through various tiers of storage are sometimes referred to as information lifecycle management (ILM) operations.", "One type of ILM operation is a hierarchical storage management (HSM) operation.", "A HSM operation is generally an operation for automatically moving data between classes of storage devices, such as between high-cost and low-cost storage devices.", "For instance, an HSM operation may involve movement of data from primary storage devices 104 to secondary storage devices 108, or between tiers of secondary storage devices 108.With each tier, the storage devices may be progressively relatively cheaper, have relatively slower access/restore times, etc.", "For example, movement of data between tiers may occur as data becomes less important over time.", "In some embodiments, an HSM operation is similar to an archive operation in that creating an HSM copy may (though not always) involve deleting some of the source data.", "For example, an HSM copy may include data from primary data 112 or a secondary copy 116 that is larger than a given size threshold or older than a given age threshold and that is stored in a backup format.", "Often, and unlike some types of archive copies, HSM data that is removed or aged from the source copy is replaced by a logical reference pointer or stub.", "The reference pointer or stub can be stored in the primary storage device 104 to replace the deleted data in primary data 112 (or other source copy) and to point to or otherwise indicate the new location in a secondary storage device 108.According to one example, files are generally moved between higher and lower cost storage depending on how often the files are accessed.", "When a user requests access to the HSM data that has been removed or migrated, the information management system 100 uses the stub to locate the data and often make recovery of the data appear transparent, even though the HSM data may be stored at a location different from the remaining source data.", "The stub may also include some metadata associated with the corresponding data, so that a file system and/or application can provide some information about the data object and/or a limited-functionality version (e.g., a preview) of the data object.", "An HSM copy may be stored in a format other than the native application format (e.g., where the data is compressed, encrypted, deduplicated, and/or otherwise modified from the original application format).", "In some cases, copies which involve the removal of data from source storage and the maintenance of stub or other logical reference information on source storage may be referred to generally as “on-line archive copies”.", "On the other hand, copies which involve the removal of data from source storage without the maintenance of stub or other logical reference information on source storage may be referred to as “off-line archive copies”.", "Auxiliary Copy and Disaster Recovery Operations An auxiliary copy is generally a copy operation in which a copy is created of an existing secondary copy 116.For instance, an initial or “primary” secondary copy 116 may be generated using or otherwise be derived from primary data 112, whereas an auxiliary copy is generated from the initial secondary copy 116.Auxiliary copies can be used to create additional standby copies of data and may reside on different secondary storage devices 108 than initial secondary copies 116.Thus, auxiliary copies can be used for recovery purposes if initial secondary copies 116 become unavailable.", "Exemplary compatible auxiliary copy techniques are described in further detail in U.S. Pat.", "No.", "8,230,195, which is incorporated by reference herein.", "The information management system 100 may also perform disaster recovery operations that make or retain disaster recovery copies, often as secondary, high-availability disk copies.", "The information management system 100 may create secondary disk copies and store the copies at disaster recovery locations using auxiliary copy or replication operations, such as continuous data replication technologies.", "Depending on the particular data protection goals, disaster recovery locations can be remote from the client computing devices 102 and primary storage devices 104, remote from some or all of the secondary storage devices 108, or both.", "Data Processing and Manipulation Operations As indicated, the information management system 100 can also be configured to implement certain data manipulation operations, which according to certain embodiments are generally operations involving the processing or modification of stored data.", "Some data manipulation operations include content indexing operations and classification operations can be useful in leveraging the data under management to provide enhanced search and other features.", "Other data manipulation operations such as compression and encryption can provide data reduction and security benefits, respectively.", "Data manipulation operations can be different than data movement operations in that they do not necessarily involve the copying, migration or other transfer of data (e.g., primary data 112 or secondary copies 116) between different locations in the system.", "For instance, data manipulation operations may involve processing (e.g., offline processing) or modification of already stored primary data 112 and/or secondary copies 116.However, in some embodiments data manipulation operations are performed in conjunction with data movement operations.", "As one example, the information management system 100 may encrypt data while performing an archive operation.", "Content Indexing In some embodiments, the information management system 100 “content indexes” data stored within the primary data 112 and/or secondary copies 116, providing enhanced search capabilities for data discovery and other purposes.", "The content indexing can be used to identify files or other data objects having pre-defined content (e.g., user-defined keywords or phrases), metadata (e.g., email metadata such as “to”, “from”, “cc”, “bcc”, attachment name, received time, etc.).", "The information management system 100 generally organizes and catalogues the results in a content index, which may be stored within the media agent database 152, for example.", "The content index can also include the storage locations of (or pointer references to) the indexed data in the primary data 112 or secondary copies 116, as appropriate.", "The results may also be stored, in the form of a content index database or otherwise, elsewhere in the information management system 100 (e.g., in the primary storage devices 104, or in the secondary storage device 108).", "Such index data provides the storage manager 140 or another component with an efficient mechanism for locating primary data 112 and/or secondary copies 116 of data objects that match particular criteria.", "For instance, search criteria can be specified by a user through user interface 158 of the storage manager 140.In some cases, the information management system 100 analyzes data and/or metadata in secondary copies 116 to create an “off-line” content index, without significantly impacting the performance of the client computing devices 102.Depending on the embodiment, the system can also implement “on-line” content indexing, e.g., of primary data 112.Examples of compatible content indexing techniques are provided in U.S. Pat.", "No.", "8,170,995, which is incorporated by reference herein.", "Classification Operations—Metabase In order to help leverage the data stored in the information management system 100, one or more components can be configured to scan data and/or associated metadata for classification purposes to populate a metabase of information.", "Such scanned, classified data and/or metadata may be included in a separate database and/or on a separate storage device from primary data 112 (and/or secondary copies 116), such that metabase related operations do not significantly impact performance on other components in the information management system 100.In other cases, the metabase(s) may be stored along with primary data 112 and/or secondary copies 116.Files or other data objects can be associated with user-specified identifiers (e.g., tag entries) in the media agent 144 (or other indices) to facilitate searches of stored data objects.", "Among a number of other benefits, the metabase can also allow efficient, automatic identification of files or other data objects to associate with secondary copy or other information management operations (e.g., in lieu of scanning an entire file system).", "Examples of compatible metabases and data classification operations are provided in U.S. Pat.", "Nos.", "8,229,954 and 7,747,579, which are incorporated by reference herein.", "Encryption Operations The information management system 100 in some cases is configured to process data (e.g., files or other data objects, secondary copies 116, etc.", "), according to an appropriate encryption algorithm (e.g., Blowfish, Advanced Encryption Standard [AES], Triple Data Encryption Standard [3-DES], etc.)", "to limit access and provide data security in the information management system 100.The information management system 100 in some cases encrypts the data at the client level, such that the client computing devices 102 (e.g., the data agents 142) encrypt the data prior to forwarding the data to other components, e.g., before sending the data media agents 144 during a secondary copy operation.", "In such cases, the client computing device 102 may maintain or have access to an encryption key or passphrase for decrypting the data upon restore.", "Encryption can also occur when creating copies of secondary copies, e.g., when creating auxiliary copies.", "In yet further embodiments, the secondary storage devices 108 can implement built-in, high performance hardware encryption.", "Management Operations Certain embodiments leverage the integrated, ubiquitous nature of the information management system 100 to provide useful system-wide management functions.", "As two non-limiting examples, the information management system 100 can be configured to implement operations management and e-discovery functions.", "Operations management can generally include monitoring and managing the health and performance of information management system 100 by, without limitation, performing error tracking, generating granular storage/performance metrics (e.g., job success/failure information, deduplication efficiency, etc.", "), generating storage modeling and costing information, and the like.", "Such information can be provided to users via the user interface 158 in a single, integrated view.", "For instance, the integrated user interface 158 can include an option to show a “virtual view” of the system that graphically depicts the various components in the system using appropriate icons.", "The operations management functionality can facilitate planning and decision-making.", "For example, in some embodiments, a user may view the status of some or all jobs as well as the status of each component of the information management system 100.Users may then plan and make decisions based on this data.", "For instance, a user may view high-level information regarding storage operations for the information management system 100, such as job status, component status, resource status (e.g., network pathways, etc.", "), and other information.", "The user may also drill down or use other means to obtain more detailed information regarding a particular component, job, or the like.", "In some cases the information management system 100 alerts a user such as a system administrator when a particular resource is unavailable or congested.", "For example, a particular primary storage device 104 or secondary storage device 108 might be full or require additional capacity.", "Or a component may be unavailable due to hardware failure, software problems, or other reasons.", "In response, the information management system 100 may suggest solutions to such problems when they occur (or provide a warning prior to occurrence).", "For example, the storage manager 140 may alert the user that a secondary storage device 108 is full or otherwise congested.", "The storage manager 140 may then suggest, based on job and data storage information contained in its database 146, an alternate secondary storage device 108.Other types of corrective actions may include suggesting an alternate data path to a particular primary or secondary storage device 104, 108, or dividing data to be stored among various available primary or secondary storage devices 104, 108 as a load balancing measure or to otherwise optimize storage or retrieval time.", "Such suggestions or corrective actions may be performed automatically, if desired.", "Further examples of some compatible operations management techniques and of interfaces providing an integrated view of an information management system are provided in U.S. Pat.", "No.", "7,343,453, which is incorporated by reference herein.", "In some embodiments, the storage manager 140 implements the operations management functions described herein.", "The information management system 100 can also be configured to perform system-wide e-discovery operations in some embodiments.", "In general, e-discovery operations provide a unified collection and search capability for data in the system, such as data stored in the secondary storage devices 108 (e.g., backups, archives, or other secondary copies 116).", "For example, the information management system 100 may construct and maintain a virtual repository for data stored in the information management system 100 that is integrated across source applications 110, different storage device types, etc.", "According to some embodiments, e-discovery utilizes other techniques described herein, such as data classification and/or content indexing.", "Information Management Policies As indicated previously, an information management policy 148 can include a data structure or other information source that specifies a set of parameters (e.g., criteria and rules) associated with secondary copy or other information management operations.", "One type of information management policy 148 is a storage policy.", "According to certain embodiments, a storage policy generally comprises a logical container that defines (or includes information sufficient to determine) one or more of the following items: (1) what data will be associated with the storage policy; (2) a destination to which the data will be stored; (3) datapath information specifying how the data will be communicated to the destination; (4) the type of storage operation to be performed; and (5) retention information specifying how long the data will be retained at the destination.", "Data associated with a storage policy can be logically organized into groups, which can be referred to as “sub-clients”.", "A sub-client may represent static or dynamic associations of portions of a data volume.", "Sub-clients may represent mutually exclusive portions.", "Thus, in certain embodiments, a portion of data may be given a label and the association is stored as a static entity in an index, database or other storage location.", "Sub-clients may also be used as an effective administrative scheme of organizing data according to data type, department within the enterprise, storage preferences, or the like.", "Depending on the configuration, sub-clients can correspond to files, folders, virtual machines, databases, etc.", "In one exemplary scenario, an administrator may find it preferable to separate e-mail data from financial data using two different sub-clients.", "A storage policy can define where data is stored by specifying a target or destination storage device (or group of storage devices).", "For instance, where the secondary storage device 108 includes a group of disk libraries, the storage policy may specify a particular disk library for storing the sub-clients associated with the policy.", "As another example, where the secondary storage devices 108 include one or more tape libraries, the storage policy may specify a particular tape library for storing the sub-clients associated with the storage policy, and may also specify a drive pool and a tape pool defining a group of tape drives and a group of tapes, respectively, for use in storing the sub-client data.", "Datapath information can also be included in the storage policy.", "For instance, the storage policy may specify network pathways and components to utilize when moving the data to the destination storage device(s).", "In some embodiments, the storage policy specifies one or more media agents 144 for conveying data (e.g., one or more sub-clients) associated with the storage policy between the source (e.g., one or more host client computing devices 102) and destination (e.g., a particular target secondary storage device 108).", "A storage policy can also specify the type(s) of operations associated with the storage policy, such as a backup, archive, snapshot, auxiliary copy, or the like.", "Retention information can specify how long the data will be kept, depending on organizational needs (e.g., a number of days, months, years, etc.)", "The information management policies 148 may also include one or more scheduling policies specifying when and how often to perform operations.", "Scheduling information may specify with what frequency (e.g., hourly, weekly, daily, event-based, etc.)", "or under what triggering conditions secondary copy or other information management operations will take place.", "Scheduling policies in some cases are associated with particular components, such as particular sub-clients, client computing device 102, and the like.", "In one configuration, a separate scheduling policy is maintained for particular sub-clients on a client computing device 102.The scheduling policy specifies that those sub-clients are to be moved to secondary storage devices 108 every hour according to storage policies associated with the respective sub-clients.", "When adding a new client computing device 102, administrators can manually configure information management policies 148 and/or other settings, e.g., via the user interface 158.However, this can be an involved process resulting in delays, and it may be desirable to begin data protecting operations quickly.", "Thus, in some embodiments, the information management system 100 automatically applies a default configuration to client computing device 102.As one example, when a data agent(s) 142 is installed on a client computing devices 102, the installation script may register the client computing device 102 with the storage manager 140, which in turn applies the default configuration to the new client computing device 102.In this manner, data protection operations can begin substantially immediately.", "The default configuration can include a default storage policy, for example, and can specify any appropriate information sufficient to begin data protection operations.", "This can include a type of data protection operation, scheduling information, a target secondary storage device 108, data path information (e.g., a particular media agent 144), and the like.", "Other types of information management policies 148 are possible.", "For instance, the information management policies 148 can also include one or more audit or security policies.", "An audit policy is a set of preferences, rules and/or criteria that protect sensitive data in the information management system 100.For example, an audit policy may define “sensitive objects” as files or objects that contain particular keywords (e.g.", "“confidential,” or “privileged”) and/or are associated with particular keywords (e.g., in metadata) or particular flags (e.g., in metadata identifying a document or email as personal, confidential, etc.).", "An audit policy may further specify rules for handling sensitive objects.", "As an example, an audit policy may require that a reviewer approve the transfer of any sensitive objects to a cloud storage site, and that if approval is denied for a particular sensitive object, the sensitive object should be transferred to a local storage device 104 instead.", "To facilitate this approval, the audit policy may further specify how a secondary storage computing device 106 or other system component should notify a reviewer that a sensitive object is slated for transfer.", "In some implementations, the information management policies 148 may include one or more provisioning policies.", "A provisioning policy can include a set of preferences, priorities, rules, and/or criteria that specify how clients 102 (or groups thereof) may utilize system resources, such as available storage on cloud storage and/or network bandwidth.", "A provisioning policy specifies, for example, data quotas for particular client computing devices 102 (e.g.", "a number of gigabytes that can be stored monthly, quarterly or annually).", "The storage manager 140 or other components may enforce the provisioning policy.", "For instance, the media agents 144 may enforce the policy when transferring data to secondary storage devices 108.If a client computing device 102 exceeds a quota, a budget for the client computing device 102 (or associated department) is adjusted accordingly or an alert may trigger.", "While the above types of information management policies 148 have been described as separate policies, one or more of these can be generally combined into a single information management policy 148.For instance, a storage policy may also include or otherwise be associated with one or more scheduling, audit, or provisioning policies.", "Moreover, while storage policies are typically associated with moving and storing data, other policies may be associated with other types of information management operations.", "The following is a non-exhaustive list of items the information management policies 148 may specify: schedules or other timing information, e.g., specifying when and/or how often to perform information management operations; the type of secondary copy 116 and/or secondary copy format (e.g., snapshot, backup, archive, HSM, etc.", "); a location or a class or quality of storage for storing secondary copies 116 (e.g., one or more particular secondary storage devices 108); preferences regarding whether and how to encrypt, compress, deduplicate, or otherwise modify or transform secondary copies 116; which system components and/or network pathways (e.g., preferred media agents 144) should be used to perform secondary storage operations; resource allocation between different computing devices or other system components used in performing information management operations (e.g., bandwidth allocation, available storage capacity, etc.", "); whether and how to synchronize or otherwise distribute files or other data objects across multiple computing devices or hosted services; and retention information specifying the length of time primary data 112 and/or secondary copies 116 should be retained, e.g., in a particular class or tier of storage devices, or within the information management system 100.Policies can additionally specify or depend on a variety of historical or current criteria that may be used to determine which rules to apply to a particular data object, system component, or information management operation, such as: frequency with which primary data 112 or a secondary copy 116 of a data object or metadata has been or is predicted to be used, accessed, or modified; time-related factors (e.g., aging information such as time since the creation or modification of a data object); deduplication information (e.g., hashes, data blocks, deduplication block size, deduplication efficiency or other metrics); an estimated or historic usage or cost associated with different components (e.g., with secondary storage devices 108); the identity of users, applications 110, client computing devices 102 and/or other computing devices that created, accessed, modified, or otherwise utilized primary data 112 or secondary copies 116; a relative sensitivity (e.g., confidentiality) of a data object, e.g., as determined by its content and/or metadata; the current or historical storage capacity of various storage devices; the current or historical network capacity of network pathways connecting various components within the storage operation cell; access control lists or other security information; and the content of a particular data object (e.g., its textual content) or of metadata associated with the data object.", "Exemplary Storage Policy and Secondary Storage Operations FIG.", "1E shows a data flow data diagram depicting performance of storage operations by an embodiment of an information management system 100, according to an exemplary data storage policy 148A.", "The information management system 100 includes a storage manger 140, a client computing device 102 having a file system data agent 142A and an email data agent 142B residing thereon, a primary storage device 104, two media agents 144A, 144B, and two secondary storage devices 108A, 108B: a disk library 108A and a tape library 108B.", "As shown, the primary storage device 104 includes primary data 112A, 112B associated with a file system sub-client and an email sub-client, respectively.", "As indicated by the dashed box, the second media agent 144B and the tape library 108B are “off-site”, and may therefore be remotely located from the other components in the information management system 100 (e.g., in a different city, office building, etc.).", "In this manner, information stored on the tape library 108B may provide protection in the event of a disaster or other failure.", "The file system sub-client and its associated primary data 112A in certain embodiments generally comprise information generated by the file system and/or operating system of the client computing device 102, and can include, for example, file system data (e.g., regular files, file tables, mount points, etc.", "), operating system data (e.g., registries, event logs, etc.", "), and the like.", "The e-mail sub-client, on the other hand, and its associated primary data 112B, include data generated by an e-mail client application operating on the client computing device 102, and can include mailbox information, folder information, emails, attachments, associated database information, and the like.", "As described above, the sub-clients can be logical containers, and the data included in the corresponding primary data 112A, 112B may or may not be stored contiguously.", "The exemplary storage policy 148A includes a backup copy rule set 160, a disaster recovery copy rule set 162, and a compliance copy rule set 164.The backup copy rule set 160 specifies that it is associated with a file system sub-client 166 and an email sub-client 168.Each of these sub-clients 166, 168 are associated with the particular client computing device 102.The backup copy rule set 160 further specifies that the backup operation will be written to the disk library 108A, and designates a particular media agent 144A to convey the data to the disk library 108A.", "Finally, the backup copy rule set 160 specifies that backup copies created according to the rule set 160 are scheduled to be generated on an hourly basis and to be retained for 30 days.", "In some other embodiments, scheduling information is not included in the storage policy 148A, and is instead specified by a separate scheduling policy.", "The disaster recovery copy rule set 162 is associated with the same two sub-clients 166, 168.However, the disaster recovery copy rule set 162 is associated with the tape library 108B, unlike the backup copy rule set 160.Moreover, the disaster recovery copy rule set 162 specifies that a different media agent 144B than the media agent 144A associated with the backup copy rule set 160 will be used to convey the data to the tape library 108B.", "As indicated, disaster recovery copies created according to the rule set 162 will be retained for 60 days, and will be generated on a daily basis.", "Disaster recovery copies generated according to the disaster recovery copy rule set 162 can provide protection in the event of a disaster or other data-loss event that would affect the backup copy 116A maintained on the disk library 108A.", "The compliance copy rule set 164 is only associated with the email sub-client 166, and not the file system sub-client 168.Compliance copies generated according to the compliance copy rule set 164 will therefore not include primary data 112A from the file system sub-client 166.For instance, the organization may be under an obligation to store maintain copies of email data for a particular period of time (e.g., 10 years) to comply with state or federal regulations, while similar regulations do not apply to the file system data.", "The compliance copy rule set 164 is associated with the same tape library 108B and media agent 144B as the disaster recovery copy rule set 162, although a different storage device or media agent could be used in other embodiments.", "Finally, the compliance copy rule set 164 specifies that copies generated under the compliance copy rule set 164 will be retained for 10 years, and will be generated on a quarterly basis.", "At step 1, the storage manager 140 initiates a backup operation according to the backup copy rule set 160.For instance, a scheduling service running on the storage manager 140 accesses scheduling information from the backup copy rule set 160 or a separate scheduling policy associated with the client computing device 102, and initiates a backup copy operation on an hourly basis.", "Thus, at the scheduled time slot the storage manager 140 sends instructions to the client computing device 102 to begin the backup operation.", "At step 2, the file system data agent 142A and the email data agent 142B residing on the client computing device 102 respond to the instructions received from the storage manager 140 by accessing and processing the primary data 112A, 112B involved in the copy operation from the primary storage device 104.Because the operation is a backup copy operation, the data agent(s) 142A, 142B may format the data into a backup format or otherwise process the data.", "At step 3, the client computing device 102 communicates the retrieved, processed data to the first media agent 144A, as directed by the storage manager 140, according to the backup copy rule set 160.In some other embodiments, the information management system 100 may implement a load-balancing, availability-based, or other appropriate algorithm to select from the available set of media agents 144A, 144B.", "Regardless of the manner the media agent 144A is selected, the storage manager 140 may further keep a record in the storage manager database 140 of the association between the selected media agent 144A and the client computing device 102 and/or between the selected media agent 144A and the backup copy 116A.", "The target media agent 144A receives the data from the client computing device 102, and at step 4 conveys the data to the disk library 108A to create the backup copy 116A, again at the direction of the storage manager 140 and according to the backup copy rule set 160.The secondary storage device 108A can be selected in other ways.", "For instance, the media agent 144A may have a dedicated association with a particular secondary storage device(s), or the storage manager 140 or media agent 144A may select from a plurality of secondary storage devices, e.g., according to availability, using one of the techniques described in U.S. Pat.", "No.", "7,246,207, which is incorporated by reference herein.", "The media agent 144A can also update its index 153 to include data and/or metadata related to the backup copy 116A, such as information indicating where the backup copy 116A resides on the disk library 108A, data and metadata for cache retrieval, etc.", "After the 30 day retention period expires, the storage manager 140 instructs the media agent 144A to delete the backup copy 116A from the disk library 108A.", "At step 5, the storage manager 140 initiates the creation of a disaster recovery copy 116B according to the disaster recovery copy rule set 162.For instance, at step 6, based on instructions received from the storage manager 140 at step 5, the specified media agent 144B retrieves the most recent backup copy 116A from the disk library 108A.", "At step 7, again at the direction of the storage manager 140 and as specified in the disaster recovery copy rule set 162, the media agent 144B uses the retrieved data to create a disaster recovery copy 116B on the tape library 108B.", "In some cases, the disaster recovery copy 116B is a direct, mirror copy of the backup copy 116A, and remains in the backup format.", "In other embodiments, the disaster recovery copy 116C may be generated in some other manner, such as by using the primary data 112A, 112B from the storage device 104 as source data.", "The disaster recovery copy operation is initiated once a day and the disaster recovery copies 116A are deleted after 60 days.", "At step 8, the storage manager 140 initiates the creation of a compliance copy 116C, according to the compliance copy rule set 164.For instance, the storage manager 140 instructs the media agent 144B to create the compliance copy 116C on the tape library 108B at step 9, as specified in the compliance copy rule set 164.In the example, the compliance copy 116C is generated using the disaster recovery copy 116B.", "In other embodiments, the compliance copy 116C is instead generated using either the primary data 112B corresponding to the email sub-client or using the backup copy 116A from the disk library 108A as source data.", "As specified, compliance copies 116C are created quarterly, and are deleted after ten years.", "While not shown in FIG.", "1E, at some later point in time, a restore operation can be initiated involving one or more of the secondary copies 116A, 116B, 116C.", "As one example, a user may manually initiate a restore of the backup copy 116A by interacting with the user interface 158 of the storage manager 140.The storage manager 140 then accesses data in its index 150 (and/or the respective storage policy 148A) associated with the selected backup copy 116A to identify the appropriate media agent 144A and/or secondary storage device 116A.", "In other cases, a media agent may be selected for use in the restore operation based on a load balancing algorithm, an availability based algorithm, or other criteria.", "The selected media agent 144A retrieves the data from the disk library 108A.", "For instance, the media agent 144A may access its index 153 to identify a location of the backup copy 116A on the disk library 108A, or may access location information residing on the disk 108A itself.", "When the backup copy 116A was recently created or accessed, the media agent 144A accesses a cached version of the backup copy 116A residing in the media agent index 153, without having to access the disk library 108A for some or all of the data.", "Once it has retrieved the backup copy 116A, the media agent 144A communicates the data to the source client computing device 102.Upon receipt, the file system data agent 142A and the email data agent 142B may unpackage (e.g., restore from a backup format to the native application format) the data in the backup copy 116A and restore the unpackaged data to the primary storage device 104.Exemplary Secondary Copy Formatting The formatting and structure of secondary copies 116 can vary, depending on the embodiment.", "In some cases, secondary copies 116 are formatted as a series of logical data units or “chunks” (e.g., 512 MB, 1 GB, 2 GB, 4 GB, or 8 GB chunks).", "This can facilitate efficient communication and writing to secondary storage devices 108, e.g., according to resource availability.", "For example, a single secondary copy 116 may be written on a chunk-by-chunk basis to a single secondary storage device 108 or across multiple secondary storage devices 108.In some cases, users can select different chunk sizes, e.g., to improve throughput to tape storage devices.", "Generally, each chunk can include a header and a payload.", "The payload can include files (or other data units) or subsets thereof included in the chunk, whereas the chunk header generally includes metadata relating to the chunk, some or all of which may be derived from the payload.", "For example, during a secondary copy operation, the media agent 144, storage manager 140, or other component may divide the associated files into chunks and generate headers for each chunk by processing the constituent files.", "The headers can include a variety of information such as file identifier(s), volume(s), offset(s), or other information associated with the payload data items, a chunk sequence number, etc.", "Importantly, in addition to being stored with the secondary copy 116 on the secondary storage device 108, the chunk headers 300 can also be stored to the index 153 of the associated media agent(s) 144 and/or the storage manager index 150.This is useful in some cases for providing faster processing of secondary copies 116 during restores or other operations.", "In some cases, once a chunk is successfully transferred to a secondary storage device 108, the secondary storage device 108 returns an indication of receipt, e.g., to the media agent 144 and/or storage manager 140, which may update their respective indexes 150, 153 accordingly.", "During restore, chunks may be processed (e.g., by the media agent 144) according to the information in the chunk header to reassemble the files.", "Additional information relating to chunks can be found in U.S. Pat.", "No.", "8,156,086, which is incorporated by reference herein.", "Data Synchronization Management System FIG.", "2 illustrates a data synchronization management system 200 according to an embodiment of the present disclosure.", "The data synchronization management system 200 can incorporate a variety of different hardware and software components, which can in turn be organized with respect to one another in many different configurations, depending on the embodiment.", "The data synchronization management system 200 of FIG.", "2 includes the storage manager 140, the secondary storage computing device(s) 106, the secondary storage device(s) 108, client computing devices 202A-C, and primary storage devices 204A-C. As described above, the storage manager 140 includes the management database 146 and the management agent 154.Additionally, the storage manager 140 includes a cloud interface 208 and a synchronization agent 210.The management database 146 includes information management policies 148, synchronization policies 151, and the management index 150, as described above.", "The secondary storage computing device(s) 106 include media agent(s) 144 and the media agent database 152, the media agent database 152 also including the index 153.The client computing devices 202A-C each may communicate with the respective primary storage devices 204A-C.", "While three client computing devices 202A-C and three primary storage devices 204A-C are shown for illustrative purposes in FIG.", "2, additional (or fewer) client computing devices and primary storage devices may be present in the data synchronization management system 200.Certain components in the system may communicate with one another via a network 206.For instance, each of the client computing devices 202A-C may communicate with the network 206.Similarly, the storage manager 140 and the secondary storage computing device(s) 106 may communicate with the network 206.Thus, through the network 206 each of the client computing devices 202A-C, the storage manager 140, and the secondary storage computing device(s) 106 may communicate with one-another.", "The network 206 may comprise any wired and/or wireless communications network suitable for data communications, and may include any of the networks, communications link, or communications pathways described herein.", "For example, the network 206 may comprise one or more of a LAN, WAN, cellular data network and/or the Internet, among others.", "Additionally, communication over the network 206 may be accomplished through any suitable communications protocol.", "For example, communication may be serial or parallel, through Universal Serial Bus (USB) (wired or wireless), Ethernet, Bluetooth, Near Field Communications (NFC), radio frequency (RF), infrared, and/or WiFi (such as any 802.1x interface), or combinations thereof, among others.", "As shown by the dotted line in FIG.", "2, the storage manager 140 and the secondary storage computing device(s) 106 may also optionally communicate with one another directly, instead of or in addition to communicating with one another via the network 206, also through any suitable communications network or protocol.", "Storage Manager in the Data Synchronization Management System In general, in the data synchronization management system 200 the storage manager 140 may include all of the functionality and components described above in reference to FIGS.", "1A-E.", "In addition, according to certain embodiments of the data synchronization management system 200, the storage manager 140 provides (among others) one or more of the following functions: tracking synchronization information related to primary copies of data on the primary storage devices 204A-C, and secondary copies of data on the secondary storage device(s) 108; tracking and resolving conflicts between similar pieces of data located in the various storage devices; managing user created data synchronization policies; and providing direct access to data stored in secondary storage device(s) 108 through a cloud interface.", "As described above, the storage manager 140 may maintain a database 146 of management-related data, such as information management and synchronization policies.", "The database 146 may include the management index 150 or other data structure that stores logical associations between components of the system, user preferences, synchronization polices and/or synchronization (and/or user) profiles (e.g., preferences regarding what data is synchronized to which devices, preferences regarding the scheduling, type, or other aspects of data synchronization operations, etc.", "), management tasks, synchronization tasks, or other useful data.", "For example, the storage manager 140 may use the index 150 to track logical associations between media agents 144 and secondary storage devices 108, movement of data from primary storage devices 204A-C to secondary storage device(s) 108, and/or synchronization states of data among the primary storage devices 204A-C.", "Thus, the data synchronization management system 200 may utilize information management policies 148 for specifying and executing information management operations, and synchronization policies 151 for specifying and executing synchronization operations (e.g., on an automated basis).", "Generally, an information management policy 148 can include a data structure or other information source that specifies a set of parameters (e.g., criteria and rules) associated with storage and/or other information management operations.", "Similarly, a synchronization policy 151 can include a data structure or other information source that specifies a set of parameters (e.g., criteria and rules) associated with synchronization operations.", "According to certain embodiments, a synchronization policy 151 generally comprises a logical container that defines (or includes information sufficient to determine) one or more of the following items: (1) what data will be associated with the synchronization policy; (2) source information associated with the data to be synchronized, such as such as the identity of primary storage device(s) 204 and/or client computing device(s) 202 storing or otherwise associated with the data, information indicating where the data is stored (e.g., primary storage address information), and the like; (4) destination information associated with the data, such as the identify of secondary storage device(s), secondary storage devices 106, and/or media agents to which the data will be synchronized; (5) datapath information specifying how the data will be communicated from sources to destinations; (6) the type of synchronization operation to be performed; and (7) the synchronization schedule.", "For example, a synchronization policy may be created by a user of the data synchronization management system 200, in which the user specifies that files and/or data to be synchronized (by specifying for inclusion, for example, files belonging to a particular directory, files having particular content, and/or files having particular associated file metadata) and the devices to which the data will be synchronized (for example, a user may specify that data and/or files associated with client computing device 202A are to be synchronized to the primary storage device 204B associated with the client computing device 202B).", "In general, in the data synchronization management system 200, a user may be identified by a user profile.", "The user profile associated with a user may include, for example, information management policies 148 and/or synchronization policies 151 of the user, an identification of the user (for example, a username), and/or a means of authenticating the identity of the user (for example, a password), among other things.", "Information management policies 148 and/or synchronization policies 151 may be associated with particular users of the data synchronization management system 200, and more than one information management policy 148 and/or synchronization policy 151 may be associated with a particular user.", "In general, synchronization polices 151 in the data synchronization management system 200 are associated with a user profile.", "The user profile may also include other information relevant to the data synchronization management system 200, including for example, backup policies, among other things.", "In the storage manager 140, the management agent 154, synchronization agent 210, and cloud interface 208, may be implemented as interconnected software modules or application programs.", "The synchronization agent 210 in some embodiments initiates, controls, and/or monitors the status of some or all synchronization or other information management operations previously performed, currently being performed, or scheduled to be performed by the data synchronization management system 200.For instance, the synchronization agent 210 may access information management policies 148 to determine when and how to initiate and control synchronization and other information management operations, as will be described further below.", "Although not depicted in FIG.", "2, embodiments of the data synchronization management system 200 generally also include the jobs agent 156 in the storage manager 140, as described above with respect to the information management system 100.Thus, information management operations may be initiated, controlled, and/or monitored by the jobs agent 156 and/or the synchronization agent 210.In an embodiment, the jobs agent 156 and the synchronization agent 210 may be a single unit.", "The cloud interface 208 may include information processing and display software, such as a graphical user interface (“GUI”), an application program interface (“API”), or other interactive interface or portal through which users and system processes may retrieve information about the status of synchronization and/or other information management operations and data (e.g., storage operations and storage locations), retrieve data and/or files directly, view file lists, and/or issue instructions to the data synchronization management system 200 and its constituent components.", "For instance, a user may access the cloud interface 208 via a browser or other application executing on one of the client computing devices 202 or another computing device.", "Via the cloud interface 208, users may optionally issue instructions to the components in the data synchronization management system 200 regarding performance of storage and recovery operations, performance of synchronization operations, and/or accessing of stored data.", "For example, a user may modify a synchronization schedule or may employ the GUI to view the status of pending storage and/or synchronization operations, or to monitor the status of certain components in the data synchronization management system 200.As another example, a user may identify and authenticate themselves (with, for example, a username and password), and view and access files and data (stored in, for example, the secondary storage device(s) 108) associated with the user.", "Data from the cloud interface 208 may be transferred over the network 206.For example, the cloud interface 208 may be accessed by a user over the Internet.", "As with the other components of the data synchronization management system 200, in other embodiments the cloud interface 208 may be located in a different part of the system (for example, in the secondary storage computing device(s) 106).", "Data and/or files may be transferred from the client computing devices 202A-C to the secondary storage device(s) via the media agent(s) 144 (and associated secondary storage computing device(s) 106).", "Thus, for example, during a secondary copy operation, files may be backed up or otherwise transferred from the primary storage device 204A to the secondary storage device(s) 108.During synchronization, the media agent(s) 144, at the direction of the storage manager 140, may communicate the files to be synchronized (e.g., through a restore operation) from the secondary storage device(s) 108 to the destination client computing device(s) 202 for storage in the associated primary storage devices 204.In another embodiment, data and/or files transferred in the data synchronization management system 200 may be transferred directly from one client computing device to another.", "Such a transfer may be under the direction of the storage manager 140.For example, storage manager 140 may direct client computing device 202A to transfer files to be synchronized directly to computing device 202B, e.g., without the use of the media agent(s) 144.Alternatively, the client computing devices 202 may include the components necessary to identify files to be synchronized, and to transfer those files to associated client computing devices directly.", "In this alternative, the storage manager 140 may snoop on the files transferred from one client computing device to another so as to identify files to be copied to secondary storage.", "Other Components in the Data Synchronization Management System As described above with respect to the information management system 100, the client computing devices 202A-C include application(s) 110 and data agent(s) 142 (although they are not depicted in FIG.", "2).", "These application(s) 110 and data agent(s) 142 generally function as described above.", "Additionally, it is to be understood that primary storage devices 204A-C store primary data, as described above.", "Similarly, the secondary storage computing device(s) 106 (including the media agent 144, media agent database 152, and index 153) and the secondary storage device(s) 108 also generally function as described above in the information management system 100.In particular, in the data synchronization management system 200, information management, information processing, information transfer, data movement, secondary copy, and data backup, archive, and other operations in general are carried out in a manner similar to that described above.", "Thus, it is to be understood that the description of the data synchronization management system 200 includes all of the functionality described above with respect to those and other operations, components, and characteristics (such as scalability).", "Exemplary Data Synchronization Management Operations and Processes FIG.", "3 illustrates an example data synchronization management process, according to an embodiment of the present disclosure.", "In general, according to certain embodiments, a data synchronization operation occurs as a result of or in response to a secondary copy operation (e.g., a data backup operation).", "The data synchronization may occur subsequent to, simultaneously with, or may at least partially overlap with the secondary copy operation, depending on the embodiment.", "While data synchronization operations may be described herein as occurring in conjunction with backup operations for the purposes of illustration, data synchronization operations may be compatible with other types of secondary copy operations in addition to backup operations, e.g., archive operations, snapshot operations, replication operations, etc.", "In an embodiment, a secondary copy operation occurs in which a copy of primary data stored in one of the primary storage devices 204A-C is created in the secondary storage device(s) 108.Then, particular identified files are synchronized (e.g., through a restore operation) to the other primary storage devices 204A-C from the secondary storage device(s) 108.This process is described in detail in reference to blocks 302, 304, and 306 below.", "At block 302, a backup operation is initiated for a first client computing device.", "For example, an information management policy 148 may specify that a backup of certain data associated with client computing device 202A is to occur.", "and the storage manager 140 may therefore initiate the backup.", "Alternatively, a user of the client computing device 202A may arbitrarily choose to manually initiate a backup, e.g., using the GUI of the storage manager 140.The data and/or file backup operation generally proceeds as detailed above (for example, as described in reference to FIG.", "1E).", "For example, the files selected for backup by the information management policy 148 may be copied from primary storage device 204A to secondary storage device(s) 108, as directed by the storage manager 140.At block 304, files in the secondary copy (for example, files backed up in the secondary storage device(s) 108) are identified for synchronization.", "Files and/or data to be synchronized are specified by the synchronization policy 151, which can be any of those described above.", "Additionally, the storage manager 140 and/or the media agent(s) 144 compare the files backed up as part of the current backup operation to the previous versions of the files located in the secondary storage device(s) 108.Files that have not changed (e.g., no changes in file contents and/or metadata) are determined to not require synchronization.", "Files that have changed in some way, however, are determined to require synchronization.", "For example, the user of the data synchronization management system 200 may specify that files contained within a particular directory are to be synchronized.", "Those files specified in the synchronization policy by the user will then be compared to previous versions of those files stored in the secondary storage device(s) 108, and files requiring synchronization will be identified by, for example, the storage manager 140 and/or media agent(s) 144.In various embodiments, the files to be synchronized may be identified before the backup is initiated, as the backup is initiated, as the backup is in progress, and/or after the backup is completed.", "Further details regarding the designation and identification of the files to be synchronized are described in reference to FIG.", "4 below.", "At block 306, those files that are identified to be synchronized are restored to specific client computing devices.", "In general, the data and/or file restore operation proceeds as detailed above (for example, as described in reference to FIG.", "1E).", "For example, files may be transferred from the secondary storage device(s) 108 to one or more of the primary storage devices 204A-C.", "User created synchronization policies may specify the specific files to be synchronized, and/or the specific devices to which those files are to be synchronized.", "For example, the user may specify that files in a particular directory on the client computing device 202A are to be synchronized with a particular directory on the client computing device 202B.", "Thus, in an embodiment, the file synchronization among client computing devices (such as client computing devices 202A-C) may be accomplished through a combination of operations similar to the backup and restore operations described above.", "In an embodiment, identified files may not be restored/synchronized from the secondary storage device(s) 108, but rather may be transferred from one client computing device to another directly.", "Thus, although the files to be synchronized may be backed up to the secondary storage device(s) 108, and the backup operation may trigger the synchronization process, the synchronization is performed by transferring the files from the source client computing device to the target client computing device.", "Thus, the bandwidth of the secondary storage computing device(s) 106's connection to the network 206 may advantageously be preserved.", "In certain embodiments, the user may specify multiple synchronization policies.", "For example, the user may specify that files located in directory “alpha” associated with client computing device 202A are to be synchronized with a version of directory “alpha” associated with client computing device 202B, while the files in directory “beta” associated with client computing device 202B are to be synchronized with a version of directory “beta” associated with client computing device 202C.", "Further, in certain embodiments, the user may specify different directories on the client computing devices to be synchronized.", "For example, the user may specify that files located in directory “alpha” associated with client computing device 202A are to be synchronized with directory “gamma” associated with client computing device 202B.", "Additionally, in certain embodiments, the user may synchronize files and/or data among more than two client computing devices.", "For example, the user may specify the particular client computing devices to which files are to be synchronized.", "Alternatively, files may be synchronized to all client computing devices associated with the user of the data synchronization management system 200.Client computing devices associated with the user may be identified, in some embodiments, through the user profile.", "For example, a user may associate themselves with all the client computing devices they own and/or manage by including the identities of those client computing devices in the user's user profile.", "FIG.", "4 illustrates an example data synchronization management process including designation of particular files, according to an embodiment of the present disclosure.", "At block 402, the data synchronization management system 200 receives parameters indicating which files and/or data to synchronize.", "In some embodiments, the user indicates and/or identifies the files, and/or criteria for identifying the files, to be synchronized.", "In some embodiments, the files and/or data to be synchronized may be identified according to some policy, and/or a policy may be automatically created when a new user profile is created and/or a user profile is associated with a particular client computing device (for example, certain types of files, such as photos, may be automatically selected for synchronization when a user profile is created).", "A user may specify the files to be synchronized.", "Files to be synchronized may be directly selected or otherwise identified, or user-defined criteria may be specified to indirectly identify the files to be synchronized.", "For instance, without limitation, files may be identified by detecting the existence of specified content within the file (such as the existence of one or more specified terms within a document), and/or by matching metadata associated with the file with one or more specified metadata parameters (such as filename, file owner, directory, creation date, modification date, size, type, location, Global Positioning System (GPS) coordinates, among others).", "The criteria used to identify files to be synchronized may vary.", "In addition, more than one criteria may be specified to identify files to be synchronized.", "For example, files to be synchronized may be identified as the files in a certain directory that were created after a certain date.", "At block 404, a backup operation is initiated for a first client computing device, similar to the operation of block 302 of FIG.", "3.The files to be backed up may be specified by a backup policy, and may include files other than and/or in addition to those files selected for synchronization.", "In an embodiment, the files designated to be synchronized are automatically included in a backup policy.", "In another embodiment, the backup policy and the synchronization policy are separate, but may be related in some way.", "The backup schedule set by the backup policy may or may not be linked to or associated with the synchronization schedule.", "In an embodiment, the synchronization policy is a subset of the backup policy.", "In an embodiment, multiple synchronization policies and backup policies may exist and/or be associated with a user profile.", "In an embodiment, files to be synchronized according to a synchronization policy are synchronized anytime any scheduled backup occurs (and/or is manually initiated).", "At block 406, the recently created backup copy is processed to identify files to be synchronized based on the received parameters discussed above in relation to block 402.For instance, the media agent 144 accesses the secondary copy from the secondary storage device(s) 108 and process the secondary copy to identify the files for synchronization.", "Similar to block 304 of FIG.", "3, in block 406 the files to be synchronized are thus identified.", "Thus, for example, when the synchronization policy specifies files in directory “delta” are to be synchronized, at block 406 the files in the secondary storage device(s) 108 that are in the designated directory “delta” (i.e., that satisfy the synchronization criteria specified by the policy) and are identified as having changed will be identified for synchronization.", "At block 408, those files that are identified to be synchronized are restored or otherwise transmitted to the target client computing devices, as described above in relation to the operation of block 306 of FIG.", "3.As described above, in an embodiment, identified files may not be restored/synchronized from the secondary storage device(s) 108, but rather may be transferred from one client computing device to another directly.", "In this embodiment the source client computing device may identify the files to be synchronized and communicate the files to the target client computing device(s).", "FIG.", "5 illustrates an example data synchronization management process including location metadata, according to an embodiment of the present disclosure.", "At block 502, the data synchronization management system 200 receives location information indicating which files and/or data to synchronize.", "In some embodiments, the user indicates and/or identifies the files to be synchronized based on the location information.", "In some embodiments, the files and/or data to be synchronized based on location information may be identified according to some policy, and/or may be automatically created when a new user profile is created and/or a user profile is associated with a particular client computing device (for example, certain files created in a particular location, such as documents created at home, may be automatically selected for synchronization when a user profile is created).", "Location information may include, for example, geographical location, personal location (such as, for example, home or work), GPS location, city, and/or state, just to name a few.", "A user may provide the location information in addition to other parameters as described above in reference to block 402 of FIG.", "4.At block 504, a backup operation is initiated for a first client computing device, similar to the operation of block 302 of FIG.", "3, and 404 of FIG.", "4.At block 506, location metadata may be included and/or added to files in the secondary copy.", "In some embodiments, a component of the data synchronization management system 200 adds location information (such as, GPS coordinates) to the metadata associated with files on the client computing devices 202A-C, in the primary copy.", "For example, in an embodiment, data agents on the client computing devices 202A-C may add location metadata to files at the point the files are created, accessed, modified, and/or designated in some other way (such as, for example, designated through a backup and/or synchronization policy).", "In other embodiments, the storage manager 140 or other appropriate component may store location information related to client computing devices 202A-C, and add location metadata to files backed up (or otherwise transferred to secondary storage).", "For example, the storage manager 140 may direct data agents on the client computing devices 202A-C to add location metadata to files when a scheduled backup operation occurs.", "Location information may include, for example, GPS coordinates, an Internet Protocol (IP) address, a street address, a geographic location (such as a city, state, etc.", "), a triangulated location based on mobile tracking with respect to telecommunications base stations, and/or computer-enabled location-based services, among others.", "Location information may be provided by the client computing device.", "Location information may also be provided by a device attached to, embedded in, or otherwise in communication with the client computing device.", "For example, location information may be provided by a GPS receiver, a network adapter, or a cellular network radio, among others.", "Alternatively, location information may be provided manually by a user.", "For example, a user may specify location information for one or more files, and/or may designate location information associated with a particular client computing device.", "In an embodiment, any combination of the above described ways of providing location information may be used.", "At block 508, file location metadata is accessed in the secondary copy (in, for example, the secondary storage device(s) 108).", "The accessed location metadata can then be used to identify files to be synchronized, according to the synchronization policy.", "For example, the user profile may include a synchronization policy that includes synchronization of all files that are created at the user's home GPS coordinates.", "Thus, identified files in the secondary copy may include those with GPS metadata indicating a location associated with, at, or near the user's home.", "At block 510, those files that are identified to be synchronized are restored to the appropriate computing devices, as described above in relation to the operation of block 306 of FIG.", "3.As described above, in an embodiment, identified files may not be restored/synchronized from the secondary storage device(s) 108, but rather may be transferred from one client computing device to another directly.", "In this embodiment, location metadata may be accessed on the client computing device to identify the files to be synchronized directly to other client computing devices.", "Remote File Access Operations and Processes FIG.", "6 illustrates an example remote file access process, according to an embodiment of the present disclosure.", "In some instances, a user of the data synchronization management system 200, through one of the client computing devices 202A-C, may request access to a file that may or may not presently be stored on the one of the client computing devices 202A-C. A file may not be present on one of the client computing devices 202A-C in certain circumstances including circumstances in which, for example, the user is attempting to access the file through the cloud interface 208 and/or the file data has not yet been synchronized to the particular client computing device.", "For example, in certain embodiments a user may utilize a client computing device to view, through the cloud interface 208, a list of files designated for synchronization.", "The list of files designated for synchronization may include files not presently synchronized to the client computing device.", "For example, a file that was recently created on another client computing device may not yet be synchronized to the user's client computing device.", "A user attempting to access files through the cloud interface 208 may thus attempt to access files that are not yet synchronized to the user's client computing device.", "Alternatively, an earlier version of the file desired by the user may be present on the user's client computing device, whereas an updated version has not yet synchronized from another client computing device where it was recently updated.", "In an embodiment, the data synchronization management system 200 may not synchronize all designated files to all client computing devices, but rather may synchronize a file list including, for example, file names and locations, but not the actual file data.", "In this embodiment, file data associated with a particular file may be synchronized to a client computing device at the time of a user's request for that file on that client computing device.", "In another embodiment, the data synchronization management system 200 may initially synchronize a file list, and subsequently synchronize the file data in the background.", "In an embodiment, the user may access a file list from any network 206 connected device, such as laptop computer with a web browser or the like.", "Thus, the user may be able to view a list of files, even though the actual file data may not be present on the network 206 connected device.", "The example remote file access process begins at block 602, at which point a file list is provided to, for example, a user.", "The file list may be provided to the user in any of the examples and embodiments described above.", "The file list may include limited file information, for example, file names, file locations, file modification dates, and/or file sizes, among other things.", "At block 604, a file access request is received from the user.", "For example, a user of the primary storage device 204B or a web browser may view the file list, and see a file that they would like to access.", "The user may then request access to that file by, for example, clicking on or otherwise selecting the file.", "Once the file access request is received, at block 606 the data synchronization management system 200 determines whether the file is locally synchronized.", "This may be accomplished, for example, by a local data agent and/or the storage manager 140.In an embodiment in which the user is attempting to access the file through a web browser and the cloud interface 208, it may be determined whether the requested file is stored in a local cache.", "In some embodiments, the file may be synchronizing in the background, and/or the locally synchronized file may be a version older than the most recent on all synchronized devices.", "In the event the current version of the requested file is locally synchronized, at block 608 the user is provided access to that local file.", "In the event the current version of the requested file is not locally synced, at block 610 the current version of the file is retrieved/synchronized from secondary storage.", "In another embodiment, the file may be retrieved directly from another client computing device, also as described above with respect to synchronization operations.", "Once the requested file is transferred to the user's device, at block 612, the user is provided access to that local copy of the file.", "In an embodiment, the user may optionally manually initiate synchronization of an accessed file.", "For example, when the user has edited the accessed file, the user may optionally manually initiate the transfer of the edited file back to the secondary storage device(s) 108.The edited file may then be synchronized to all related devices according to the synchronization policy.", "The user profile may include synchronization policies specifying those files that are accessible through the remote file access process, as well as those that are not.", "For example, the user may specify that only particular files and/or data are to be available through the cloud interface 208.The user may likely specify that all synchronized files, or no synchronized files are to be available through the cloud interface 208.File Conflicts It may occur during the operation of the data synchronization management system 200 that file conflicts and/or inconsistencies arise.", "For example, the same file may be edited simultaneously in two of the client computing devices 202A-C.", "In this event, each file may be synchronized to the other client computing device, creating a conflict.", "In an embodiment, this conflict may be resolved in an automated fashion.", "For certain file types, the differences may be merged according to any appropriate method.", "In some instances, one or more of the conflicting files may be renamed, and the user notified of the conflict for manual resolution.", "In general, even conflicted files will continue to be synchronized and backed up according to applicable policies.", "Other Embodiments In an embodiment, one or more media agent(s) 144 may manage the synchronization of data and/or files among the client computing devices 202A-C.", "The media agent(s) 144 may determine whether changes have been made to backed up files that are designated for synchronization, and thus may determine whether or not a synchronization/restore operation occurs with respect to the other client computing device.", "In various embodiments, a synchronization policy may include the options for two-way synchronization and/or one-way synchronization.", "In two-way synchronization, files and/or data may be synchronized both to and from a destination.", "For example, a synchronization policy may indicate that files should be two-way synchronized between client computing device 202A and client computing device 202B.", "Thus, any changes on either of the devices would be synchronized to the other device.", "Alternatively, a synchronization policy may indicate that files should be one-way synchronized.", "For example, one-way synchronization from client computing device 202A to client computing device 202B would cause any changes to synchronized files on client computing device 202A to be synchronized to client computing device 202B, but not the other way around.", "Alternatively, a reverse one-way synchronization would cause any changes on client computing device 202B to be synchronized to client computing device 202A, but not the other way around.", "In an embodiment, when a client computing device that is part of a synchronization policy is offline (for example, it is not connected to the network 206, or it is powered down), the data synchronization management system 200 will wait until that client computing device comes back online to synchronize files and data to that client computing device.", "This may be accomplished, for example, through a polling process in which the storage manager 140 (or other component of the data synchronization management system 200) periodically polls the client computing devices 202A-C to determine whether they are connected to the network 206.Alternatively, the client computing devices 202A-C may periodically send notification to the storage manager 140 (or other component of the data synchronization management system 200) when they are connected to the network 206.In an embodiment, the connectedness of the client computing device is not determined until a scheduled or forced backup and/or synchronization occurs.", "In another embodiment, the client computing devices 202A-C send notification to the storage manager 140 (or other component of the data synchronization management system 200) when they are initially connected to the network 206.In an embodiment, all data transferred within the data synchronization management system 200 is encrypted.", "The encrypted data may then be unencrypted when the user is identified and the identity of the user is authenticated.", "Additionally, in an embodiment, the data associated with the data synchronization management system 200 does not leave the ecosystem of the data synchronization management system 200.For example, the data synchronization management system 200 may comprise a local area network and/or enterprise network in which all communications are authenticated and encrypted.", "Thus, no unencrypted data is transferred out of the information management system to, for example, the open internet.", "Further, various data associated with various user profiles may be kept entirely separate (for example, encrypted separately).", "In an embodiment, data and files in the data synchronization management system 200 are deduplicated at the file and/or block level.", "Thus, a file stored in secondary storage device(s) 108 is only stored once, even though it may be synchronized across multiple client computing devices, and although each of those client computing devices may have a separate backup policy involving that file.", "It is to be understood that the various embodiments of the data synchronization management system 200 described may include any or all of the various components of the information management system 100 described above, including, but not limited to, data movement operations, backup operations, archive operations, snapshot operations, replication operations, deduplication operations, data processing and manipulations operations, content indexing, metabase classification operations, encryption operations, and/or management operations.", "User Interface Screenshots FIGS.", "7A-G illustrate exemplary screenshots of pages of the user interface of the data synchronization management system 200, according to various embodiments of the present disclosure.", "In FIGS.", "7A-G, the term ‘cloud folder’ may be understood to refer to, without limitation, synchronization policies as described in the present disclosure.", "Screenshot 700 of FIG.", "7A shows an exemplary page of a user interface of the data synchronization management system 200 including a listing of backup information 702, a current backup status display 704, a listing of backup schedules 706, a listing of content 707, synchronization information 708, and a last seen location window 709.In screenshot 700, user “backup1” has implemented a backup policy on a client computing device.", "The listing of backup information 702 includes the date and time of the last backup, the last backup size, the total backup size, and the date and time this client computing device was last seen online.", "The current backup status display 704 indicates that there is a current backup in process, and no backups are scheduled.", "The backup schedules 706 button allows the user may schedule backups.", "The listing of content 707 field indicates directories that the user has specified for back up.", "The synchronization information 708 field allows the user to set synchronization policies by clicking the “Sync backup1 using Cloud Folders” link.", "The last seen location window 709 shows the client computing devices last seen location.", "The last seen location window 709 indicates that the client computing device associated with user interface of screenshot 700 includes a means of gathering location data that may be associated files to be backed up and/or synchronized.", "The screenshot 710 of FIG.", "7B shows an exemplary page of the user interface when a user chooses to create a synchronization policy, including a select folder path radio button 711, an all backed-up data radio button 712, a two-way sync radio button 714, and one-way sync to cloud folder radio button 716.In screenshot 710, the user has specified a folder/synchronize policy name, “folder1.” Using the select folder path radio button 711, the user may choose particular folders/directories to synchronize.", "By selecting the all backed-up data radio button 712, the user may choose to synchronize all data that is already part of the backup policy.", "Using the two-way sync radio button 714, the user may choose to synchronize file changes both ways (i.e., file changes on this client computing device are synchronized to other client computing devices, and likewise changes on other client computing devices are synchronized to this client computing device).", "Alternatively, the user may use the one-way sync to cloud folder radio button 716 to synchronize files one way (i.e., file changes on this client computing device are synchronized to other client computing devices, but not the other way around).", "Screenshot 720 of FIG.", "7C shows another exemplary page of the user interface when a user chooses the select folder path radio button 711 of the page shown in FIG.", "7B.", "The page includes a listing 721 of backed up content.", "The listing 721 includes a deselected folder 722 and a selected folder 724.The listing shows directories that will be synchronized under the present synchronization policy.", "The deselected folder 722 is a folder/directory that is not selected for synchronization.", "The selected folder 724 is a folder/directory that is selected for synchronization.", "Screenshot 730 of FIG.", "7D shows an exemplary page of the user interface after a synchronization policy/cloud folder “folder1” has been created, as indicated by field 732.Screenshot 740 of FIG.", "7E shows another exemplary page of the user interface in which synchronization policies may be set.", "The page includes a listing of cloud folders including folder1 information tab 741, a listing of synchronization clients 742, a listing of sync options including two-way sync mode 744, only upload contents to cloud folder sync mode 746, and only download contents to cloud folder sync mode 748, and a default directory field 749.Folder1 information tab 741 indicates the current synchronization policy that is being set, as well as the directory path that is being synchronized.", "The listing of synchronization clients 742 indicates the destinations to which the files of the current synchronization policy will be synchronized.", "For each of the four listed synchronization clients 742, the user may select a synchronization mode from the listing of sync options.", "The modes include: two-way sync mode 744 (synchronization both to and from the destination/client), only upload contents to cloud folder sync mode 746 (only synchronize to the destination/client), and only download contents to cloud folder sync mode 748 (only synchronize from the destination/client).", "At default directory 749 the user may set the path of the default download/upload path.", "Screenshot 750 of FIG.", "7F shows yet another exemplary page of user interface in which synchronization policies may be set.", "The page includes two highlighted active cloud folders, indicated by the highlighted folder1 information tab 751 and folder2 information tab 752.The page also includes four inactive cloud folders, indicated by the greyed out folder information tabs 754.Active cloud folders may include those in which files are currently synchronizing, file synchronization is currently paused, and/or a synchronization schedule is set.", "Conversely, inactive cloud folders may include those in which files are not currently synchronizing, file synchronization is not currently paused, and/or a synchronization schedule is not set.", "As shown, multiple synchronization policies (cloud folders) may be set.", "In screenshot 750, folder1 information tab 751 and folder2 information tab 752 indicate folders that are currently active, while folder information tabs 754 indicate those that are currently inactive.", "Screenshot 760 of FIG.", "7G shows an exemplary page of the user interface in which synchronization policies may be set.", "The page includes active cloud folders folder4 and folder 2, indicated by information tabs 761 and 762.The page also includes inactive cloud folders folder 3, folder5, and folder6 indicated by information tab 764.Further, the page includes inactive cloud folder folder1 indicated by information tab 766.Folder4 (indicated by information tab 761) is active and currently synchronizing, while folder2 (indicated by information tab 762) is currently paused (not synchronizing).", "Formerly active (as shown in the page of screenshot 750), folder1 is now inactive, as indicated by information tab 766.Thus, the data synchronization management system 200 advantageously enables synchronization of files and/or data among various client computing devices simultaneously with backups of files and/or data.", "Advantageously, various synchronization policies may be set and adjusted by a user, specifying files to be synchronized based on parameters (file data, contents, and/or metadata) such as, for example, file location, file type, file size, file creation and/or modification, and/or location information.", "Additionally, synchronization policies may specify the devices to which various files should be synchronized.", "Further, the data synchronization management system 200 advantageously enables a user to access synchronized files through a cloud interface 208 from any location.", "Terminology Conditional language, such as, among others, “can,” “could,” “might,” or “may,” unless specifically stated otherwise, or otherwise understood within the context as used, is generally intended to convey that certain embodiments include, while other embodiments do not include, certain features, elements and/or steps.", "Thus, such conditional language is not generally intended to imply that features, elements and/or steps are in any way required for one or more embodiments or that one or more embodiments necessarily include logic for deciding, with or without user input or prompting, whether these features, elements and/or steps are included or are to be performed in any particular embodiment.", "Depending on the embodiment, certain acts, events, or functions of any of the algorithms described herein can be performed in a different sequence, can be added, merged, or left out all together (e.g., not all described acts or events are necessary for the practice of the algorithms).", "Moreover, in certain embodiments, acts or events can be performed concurrently, e.g., through multi-threaded processing, interrupt processing, or multiple processors or processor cores or on other parallel architectures, rather than sequentially.", "Systems and modules described herein may comprise software, firmware, hardware, or any combination(s) of software, firmware, or hardware suitable for the purposes described herein.", "Software and other modules may reside on servers, workstations, personal computers, computerized tablets, PDAs, and other devices suitable for the purposes described herein.", "Software and other modules may be accessible via local memory, via a network, via a browser, or via other means suitable for the purposes described herein.", "Data structures described herein may comprise computer files, variables, programming arrays, programming structures, or any electronic information storage schemes or methods, or any combinations thereof, suitable for the purposes described herein.", "User interface elements described herein may comprise elements from graphical user interfaces, command line interfaces, and other suitable interfaces.", "Further, the processing of the various components of the illustrated systems can be distributed across multiple machines, networks, and other computing resources.", "In addition, two or more components of a system can be combined into fewer components.", "Various components of the illustrated systems can be implemented in one or more virtual machines, rather than in dedicated computer hardware systems.", "Likewise, the data repositories shown can represent physical and/or logical data storage, including, for example, storage area networks or other distributed storage systems.", "Moreover, in some embodiments the connections between the components shown represent possible paths of data flow, rather than actual connections between hardware.", "While some examples of possible connections are shown, any of the subset of the components shown can communicate with any other subset of components in various implementations.", "Embodiments are also described above with reference to flow chart illustrations and/or block diagrams of methods, apparatus (systems) and computer program products.", "Each block of the flow chart illustrations and/or block diagrams, and combinations of blocks in the flow chart illustrations and/or block diagrams, may be implemented by computer program instructions.", "Such instructions may be provided to a processor of a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions, which execute via the processor of the computer or other programmable data processing apparatus, create means for implementing the acts specified in the flow chart and/or block diagram block or blocks.", "These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to operate in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including instruction means which implement the acts specified in the flow chart and/or block diagram block or blocks.", "The computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operations to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the acts specified in the flow chart and/or block diagram block or blocks.", "While certain embodiments have been described, these embodiments have been presented by way of example only, and are not intended to limit the scope of the disclosure.", "Indeed, the novel methods and systems described herein may be embodied in a variety of other forms; furthermore, various omissions, substitutions and changes in the form of the described methods and systems may be made without departing from the spirit of the disclosure.", "The accompanying claims and their equivalents are intended to cover such forms or modifications as would fall within the scope and spirit of the disclosure." ] ]
Patent_15875950
[ [ "Data Processing Method, Apparatus, and System", "A server receives target data sent by a mobile terminal, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal.", "When the amount of change in posture variation is smaller than the preset variation threshold, such fact indicates that the posture when the mobile terminal sends the target data hardly changes compared with the postures that the mobile terminal historically sends the target data to the server.", "As the posture of the mobile terminal is frequently changed during the process of normal use of the mobile terminal, the target data sent by the mobile terminal without posture change is regarded as false data.", "Thus, the present techniques ensure the fairness and efficiency of data processing." ], [ "1.A method comprising: receiving target data sent by a mobile terminal, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal; obtaining a historical parameter set in historical data corresponding to the mobile terminal, the historical parameter set including at least a historical posture parameter of the mobile terminal; and in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determining that the target data is false data.", "2.The method of claim 1, wherein: the parameter set satisfying the preset condition includes at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold.", "3.The method of claim 2, wherein: the target posture parameter includes: an angle α1 between the mobile terminal and a magnetic north; an angle of rotation β1 that the mobile terminal is rotated about a horizontal axis X; and an angle of rotation γ1 that the mobile terminal is rotated about a horizontal axis Z; the historical posture parameter includes: a historical angle α2 between the mobile terminal and the magnetic north; an angle of rotation β2 that the mobile terminal is rotated about the horizontal axis X; and an angle of rotation β2 that the mobile terminal is rotated about the horizontal axis Z; and the posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is determined by using a value calculated from a formula √{square root over ((α−α2)2−(β−β2)2−(γ−γ2)2 )}.", "4.The method of claim 1, wherein: the parameter set further includes a sending time of the target data; and the parameter set satisfying the preset condition includes that a time interval that the mobile terminal sends data is less than a predetermined time length, the time interval being determined by the sending time of the target data and a sending time of historical data in the historical parameter set.", "5.The method of claim 4, wherein a process to determine the time interval includes: using a latest time that the mobile terminal sends data as the sending time of the historical data; and determining a time difference between the sending time of the target data and the sending time of the historical data as the time interval.", "6.The method of claim 1, wherein: the parameter set further includes a location identifier of the mobile terminal; and the parameter set satisfying the preset condition includes that locations of the mobile terminal and a set of historical false terminal are within a preset range according to the location identifier, the set of historical false terminal including one or more historical false terminals.", "7.The method of claim 6, wherein: when the set of historical false terminal includes multiple historical false terminals, a distance between adjacent historical false terminals is less than a preset distance threshold.", "8.The method of claim 5, wherein: the location identifier includes latitude and longitude data when the mobile terminal sends the target data; and a process determining that locations of the mobile terminal and the set of historical false terminal are within the preset range according to the location identifier includes: determining latitude and longitude data of the set of historical false terminal; calculating a distance between the latitude and longitude data of the mobile terminal that sends the target data and the latitude and longitude data of the set of historical false terminal; in response to determining that the distance is less than a preset distance threshold, determining that the locations of the mobile terminal and the set of historical false terminal are within the preset range.", "9.The method of claim 8, wherein the latitude and longitude data of the set of historical false terminal includes latitude and longitude data of center points of shapes of various historical false terminals in the set of historical false terminal.", "10.The method of claim 5, wherein: the location identifier includes a base station identifier of a base station whose coverage includes the mobile terminal when the mobile terminal sends the target data; and a process determining that locations of the mobile terminal and the set of historical false terminal are within the preset range according to the location identifier includes: determining the base station identifier of the set of historical false terminal; in response to determining that the base station identifier of the base station that the mobile terminal uses to send the target data coincides with the base station identifier of the set of historical false terminal, determining that the locations of the mobile terminal and the set of historical false terminal are within the preset range.", "11.The method of claim 10, wherein: the base station identifier is a Cell Global Identifier (CGI); 12.The method of claim 5, wherein: the location identifier includes a WIFI hot spot identifier of a WIFI hot spot whose coverage includes the mobile terminal when the mobile terminal sends the target data; and a process determining that locations of the mobile terminal and the set of historical false terminal are within the preset range according to the location identifier includes: determining a WIFI hot spot identifier of the set of historical false terminal; in response to determining that the WIFI hot spot identifier of the WIFI hot spot that the mobile terminal uses to send the target data coincides with the WIFI hot spot of the set of historical false terminal, determining that the locations of the mobile terminal and the set of historical false terminal are within the preset range.", "13.The method of claim 12, wherein: the WIFI hotspot identifier is a service set identifier (SSID) or a basic service set identification (BSSID).", "14.The method of claim 1, further comprising: after, in response to determining that the parameter set satisfies the preset condition according to the historical parameter set, determining that the target data is false data, blocking the false data; and determining that the mobile terminal is a false terminal.", "15.The method of claim 1, further comprising: in response to determining that the parameter set does not satisfy the preset condition, in response to the target data, sending response information to the mobile terminal.", "16.The method of claim 1, wherein: the target data is target transaction data; and the historical data is the historical transaction data.", "17.A method comprising: generating target data, the target data carrying a parameter set, the parameter set including at least a target posture parameter of a mobile terminal; and sending the target data.", "18.The method of claim 17, wherein: the parameter set is a basis to determine that the target data is false data such that a server obtains a historical parameter set in historical data corresponding to the mobile terminal and, in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data, the historical parameter set including at least a historical posture parameter of the mobile terminal, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold 19.The method of claim 17, wherein the parameter set also includes a sending time of the target data or a location identifier of the mobile terminal.", "20.An apparatus comprising: one or more processors; and one or more memories storing thereon computer-readable instructions that, when executed by the one or more processors, cause the one or more processors to perform acts comprising: receiving target data sent by a mobile terminal, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal; obtaining a historical parameter set in historical data corresponding to the mobile terminal, the historical parameter set including at least a historical posture parameter of the mobile terminal; and in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determining that the target data is false data, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold." ], [ "<SOH> BACKGROUND <EOH>With the development of network technology, electronic business platform is becoming mature and is developing rapidly, and has become an important shopping channel in people's lives.", "When people shop through a electronic business platform, they usually prefer high reputation shops or high sales of merchandise.", "After understanding consumer shopping psychology, criminals send false data electronic to the electronic business platform to achieve or enhance the credibility of shops for selling purposes.", "With the increasing popularity of mobile terminals, criminals have gradually begin to use the mobile terminal to send false data to the electronic business platform to achieve false trading, etc.", "to enhance the credibility of the shops or sales.", "The conventional technologies for identifying false data only identify false data sent by the PC machine.", "Thus, there is a need of a method for identifying false data sent by the mobile terminals." ], [ "<SOH> SUMMARY <EOH>This Summary is provided to introduce a selection of concepts in a simplified form that are further described below in the Detailed Description.", "This Summary is not intended to identify all key features or essential features of the claimed subject matter, nor is it intended to be used alone as an aid in determining the scope of the claimed subject matter.", "The term “technique(s) or technical solution(s)” for instance, may refer to apparatus(s), system(s), method(s) and/or computer-readable instructions as permitted by the context above and throughout the present disclosure.", "The present disclosure provides a method and device for multi-display interaction, which makes the interaction process more vivid and real, which improves the user engagement.", "In view of this, the present disclosure provides a data processing method and apparatus for identifying false data transmitted by mobile terminals, thereby maintaining an ordinary transaction course of an electronic business platform.", "The present disclosure provides the following technical solutions: The present disclosure provides a data processing method comprising: receiving target data sent by a mobile terminal, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal; obtaining historical parameter set in historical data corresponding to the mobile terminal, the historical parameter set including at least a historical posture parameter of the mobile terminal; and in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determining that the target data is false data, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold.", "For example, the target posture parameter includes an angle α 1 between the mobile terminal and the magnetic north, an angle of rotation β 1 that the mobile terminal is rotated about the horizontal axis X, an angle of rotation γ 1 that the mobile terminal is rotated about the horizontal axis Z.", "The historical posture parameter includes a historical angle α 2 between the mobile terminal and the magnetic north, an angle of rotation β 2 that the mobile terminal is rotated about the horizontal axis X, an angle of rotation γ 2 that the mobile terminal is rotated about the horizontal axis Z.", "Thus, the posture variation determined by the target posture parameter and the historical posture parameter is determined, which includes using the value arising from the formula √{square root over ((α−α 2 ) 2 −(β−β 2 ) 2 −(γ−γ 2 ) 2 )} as the posture variation.", "For example, the parameter set also includes a sending time of the target data.", "The parameter set satisfying the preset condition also includes that a time interval that the mobile terminal sends data is less than a predetermined time length.", "The time interval is determined by the sending time of the target data and the sending time of the historical data in the historical parameter set.", "For example, the determining the time interval includes: using a latest time that the mobile terminal sends data as the sending time of the historical data.", "The time difference between the sending time of the target data and the sending time of the historical data.", "For example, the parameter set also includes a location identifier of the mobile terminal.", "The parameter set satisfying the preset condition also includes that the locations of the mobile terminal and the set of historical false terminal are within a preset range according to the location identifier.", "The set of historical false terminal includes one or more historical false terminals.", "For example, when the set of historical false terminal includes multiple historical false terminals, the distance between adjacent historical false terminals is less than a preset distance threshold.", "For example, the location identifier includes latitude and longitude data, a base station identifier, and/or a WIFI hotspot identifier of the mobile terminal when the mobile terminal sends the target data.", "The determining process that the locations of the mobile terminal and the set of historical false terminal are within a preset range according to the location identifier includes: determining latitude and longitude data of the set of historical false terminal; calculating a distance between the latitude and longitude data of the mobile terminal that sends the target data and the latitude and longitude data of the set of historical false terminal; in response to determining that the distance is less than a preset distance threshold, determining that the locations of the mobile terminal and the set of historical false terminal are within the preset range; determining the base station identifier of the set of historical false terminal; in response to determining that the base station identifier of the base station that the mobile terminal uses to send the target data coincides with the base station identifier of the set of historical false terminal, determining that the locations of the mobile terminal and the set of historical false terminal are within the preset range; or determining a WIFI hot spot identifier of the set of historical false terminal; in response to determining that the WIFI hot spot identifier of the WIFI hot spot that the mobile terminal uses to send the target data coincides with the WIFI hot spot of the set of historical false terminal, determining that the locations of the mobile terminal and the set of historical false terminal are within the preset range.", "For example, the latitude and longitude data of the set of historical false terminal includes the latitude and longitude data of the center points of the shapes of various historical false terminals in the set of historical false terminal.", "For example, the base station identifier is the Cell Global Identifier (CGI).", "The WIFI hotspot identifier is the service set identifier SSID or basic service set identification (BSSID).", "For example, if the parameter set meets a preset condition, after determining that the target data is false data, the method further includes: blocking the false data; and determining that the mobile terminal is a false terminal.", "For example, if parameter set does not meet a preset condition, in response to the target data, the response information is sent to the mobile terminal.", "For example, the target data is target transaction data and the historical data is the historical transaction data.", "The present disclosure provides another data processing method comprising: generating target data, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal, the parameter set being a basis to determine that the target data is false data such that a server obtains a historical parameter set in historical data corresponding to the mobile terminal and, in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data, the historical parameter set including at least a historical posture parameter of the mobile terminal, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold; and sending the target data to the server.", "For example, the parameter set also includes a sending time of the target data and/or a location identifier of the mobile terminal.", "For example, the method further includes receiving the response information sent by the server.", "The response information is sent by the server to respond to the target data after the server determines that the parameter set does not satisfy the preset condition.", "For example, the target data is target transaction data and the historical data is the historical transaction data.", "For example, the present disclosure provides a data processing apparatus comprising: a target data receiving module that receives target data sent by a mobile terminal, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal; a historical parameter set obtaining module that obtains a historical parameter set in historical data corresponding to the mobile terminal, the historical parameter set including at least a historical posture parameter of the mobile terminal; and a false data determining module that, in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold.", "For example, the parameter set also includes a sending time of the target data.", "The false data determining module further determines the time interval that the mobile terminal sends data is less than a preset time length.", "The time interval is determined by the sending time of the target data and the sending time of the historical data in the historical parameter set.", "For example, the parameter set also includes a location identifier of the mobile terminal.", "The false data determining module further determines that the locations of the mobile terminal and the set of historical false terminal are within a preset range according to the location identifier.", "The set of historical false terminal includes one or more historical false terminals.", "For example, the data processing apparatus further includes a blocking module that blocks the false data; and a false terminal determining module that determines the mobile terminal as a false terminal.", "For example, the data processing apparatus also includes a response information sending module that, when the parameter set does not satisfy the preset condition, in response to the target data, sends response information to the mobile terminal.", "For example, the target data is target transaction data and the historical data is the historical transaction data.", "The present disclosure provides another data processing apparatus comprising: a target data generating module that generates target data, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal, the parameter set being a basis to determine that the target data is false data such that a server obtains a historical parameter set in historical data corresponding to the mobile terminal and, in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data, the historical parameter set including at least a historical posture parameter of the mobile terminal, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold; and a target data sending module that sends the target data to the server.", "For example, the data processing apparatus also includes a response information sending module that receives response information sent by the server.", "The response information is sent by the server to respond to the target data after the server determines that the parameter set does not satisfy the preset condition.", "For example, the target data is target transaction data and the historical data is the historical transaction data.", "The present disclosure also provides a data processing system including a mobile terminal and a server.", "The mobile terminal generates target data and sends the target data to the server.", "The server receives the target data sent by the mobile terminal, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal; obtains a historical parameter set in historical data corresponding to the mobile terminal, the historical parameter set including at least a historical posture parameter of the mobile terminal; and in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold.", "For example, the target data is target transaction data and the historical data is the historical transaction data.", "In the data processing method of the present disclosure, the server receives the target data carrying the parameter set sent by the mobile terminal.", "The parameter set includes at least a target posture parameter of the mobile terminal.", "In response to determining that the posture variation between the target posture parameter and the historical posture parameter is less than a preset variation threshold, the server determines that the parameter set satisfies the preset condition and determines the target data as false data.", "In this process, the amount of change in posture variation being smaller than the preset variation threshold indicates that the posture that the mobile terminal sends the target data hardly changes compared with the postures that the mobile terminal historically sends the target data to the server.", "As the posture of the mobile terminal is frequently changed during the process of normal use of the mobile terminal, the target data sent by the mobile terminal without posture change is regarded as false data.", "Then the mobile terminal that sends the false data is identified, thereby ensuring the fairness and efficiency of data processing." ], [ "CROSS REFERENCE TO RELATED PATENT APPLICATIONS This application claims priority to and is a continuation of PCT Patent Application No.", "PCT/CN2016/089595, filed on 11 Jul.", "2016, which claims priority to Chinese Patent Application No.", "201510427882.4, filed on 20 Jul.", "2015, entitled “Data Processing Method, Apparatus, and System,” which are hereby incorporated by reference in their entirety.", "TECHNICAL FIELD The present disclosure relates to the field of Internet technologies, and particularly to a data processing method, apparatus, and system.", "BACKGROUND With the development of network technology, electronic business platform is becoming mature and is developing rapidly, and has become an important shopping channel in people's lives.", "When people shop through a electronic business platform, they usually prefer high reputation shops or high sales of merchandise.", "After understanding consumer shopping psychology, criminals send false data electronic to the electronic business platform to achieve or enhance the credibility of shops for selling purposes.", "With the increasing popularity of mobile terminals, criminals have gradually begin to use the mobile terminal to send false data to the electronic business platform to achieve false trading, etc.", "to enhance the credibility of the shops or sales.", "The conventional technologies for identifying false data only identify false data sent by the PC machine.", "Thus, there is a need of a method for identifying false data sent by the mobile terminals.", "SUMMARY This Summary is provided to introduce a selection of concepts in a simplified form that are further described below in the Detailed Description.", "This Summary is not intended to identify all key features or essential features of the claimed subject matter, nor is it intended to be used alone as an aid in determining the scope of the claimed subject matter.", "The term “technique(s) or technical solution(s)” for instance, may refer to apparatus(s), system(s), method(s) and/or computer-readable instructions as permitted by the context above and throughout the present disclosure.", "The present disclosure provides a method and device for multi-display interaction, which makes the interaction process more vivid and real, which improves the user engagement.", "In view of this, the present disclosure provides a data processing method and apparatus for identifying false data transmitted by mobile terminals, thereby maintaining an ordinary transaction course of an electronic business platform.", "The present disclosure provides the following technical solutions: The present disclosure provides a data processing method comprising: receiving target data sent by a mobile terminal, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal; obtaining historical parameter set in historical data corresponding to the mobile terminal, the historical parameter set including at least a historical posture parameter of the mobile terminal; and in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determining that the target data is false data, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold.", "For example, the target posture parameter includes an angle α1 between the mobile terminal and the magnetic north, an angle of rotation β1 that the mobile terminal is rotated about the horizontal axis X, an angle of rotation γ1 that the mobile terminal is rotated about the horizontal axis Z.", "The historical posture parameter includes a historical angle α2 between the mobile terminal and the magnetic north, an angle of rotation β2 that the mobile terminal is rotated about the horizontal axis X, an angle of rotation γ2 that the mobile terminal is rotated about the horizontal axis Z.", "Thus, the posture variation determined by the target posture parameter and the historical posture parameter is determined, which includes using the value arising from the formula √{square root over ((α−α2)2−(β−β2)2−(γ−γ2)2 )} as the posture variation.", "For example, the parameter set also includes a sending time of the target data.", "The parameter set satisfying the preset condition also includes that a time interval that the mobile terminal sends data is less than a predetermined time length.", "The time interval is determined by the sending time of the target data and the sending time of the historical data in the historical parameter set.", "For example, the determining the time interval includes: using a latest time that the mobile terminal sends data as the sending time of the historical data.", "The time difference between the sending time of the target data and the sending time of the historical data.", "For example, the parameter set also includes a location identifier of the mobile terminal.", "The parameter set satisfying the preset condition also includes that the locations of the mobile terminal and the set of historical false terminal are within a preset range according to the location identifier.", "The set of historical false terminal includes one or more historical false terminals.", "For example, when the set of historical false terminal includes multiple historical false terminals, the distance between adjacent historical false terminals is less than a preset distance threshold.", "For example, the location identifier includes latitude and longitude data, a base station identifier, and/or a WIFI hotspot identifier of the mobile terminal when the mobile terminal sends the target data.", "The determining process that the locations of the mobile terminal and the set of historical false terminal are within a preset range according to the location identifier includes: determining latitude and longitude data of the set of historical false terminal; calculating a distance between the latitude and longitude data of the mobile terminal that sends the target data and the latitude and longitude data of the set of historical false terminal; in response to determining that the distance is less than a preset distance threshold, determining that the locations of the mobile terminal and the set of historical false terminal are within the preset range; determining the base station identifier of the set of historical false terminal; in response to determining that the base station identifier of the base station that the mobile terminal uses to send the target data coincides with the base station identifier of the set of historical false terminal, determining that the locations of the mobile terminal and the set of historical false terminal are within the preset range; or determining a WIFI hot spot identifier of the set of historical false terminal; in response to determining that the WIFI hot spot identifier of the WIFI hot spot that the mobile terminal uses to send the target data coincides with the WIFI hot spot of the set of historical false terminal, determining that the locations of the mobile terminal and the set of historical false terminal are within the preset range.", "For example, the latitude and longitude data of the set of historical false terminal includes the latitude and longitude data of the center points of the shapes of various historical false terminals in the set of historical false terminal.", "For example, the base station identifier is the Cell Global Identifier (CGI).", "The WIFI hotspot identifier is the service set identifier SSID or basic service set identification (BSSID).", "For example, if the parameter set meets a preset condition, after determining that the target data is false data, the method further includes: blocking the false data; and determining that the mobile terminal is a false terminal.", "For example, if parameter set does not meet a preset condition, in response to the target data, the response information is sent to the mobile terminal.", "For example, the target data is target transaction data and the historical data is the historical transaction data.", "The present disclosure provides another data processing method comprising: generating target data, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal, the parameter set being a basis to determine that the target data is false data such that a server obtains a historical parameter set in historical data corresponding to the mobile terminal and, in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data, the historical parameter set including at least a historical posture parameter of the mobile terminal, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold; and sending the target data to the server.", "For example, the parameter set also includes a sending time of the target data and/or a location identifier of the mobile terminal.", "For example, the method further includes receiving the response information sent by the server.", "The response information is sent by the server to respond to the target data after the server determines that the parameter set does not satisfy the preset condition.", "For example, the target data is target transaction data and the historical data is the historical transaction data.", "For example, the present disclosure provides a data processing apparatus comprising: a target data receiving module that receives target data sent by a mobile terminal, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal; a historical parameter set obtaining module that obtains a historical parameter set in historical data corresponding to the mobile terminal, the historical parameter set including at least a historical posture parameter of the mobile terminal; and a false data determining module that, in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold.", "For example, the parameter set also includes a sending time of the target data.", "The false data determining module further determines the time interval that the mobile terminal sends data is less than a preset time length.", "The time interval is determined by the sending time of the target data and the sending time of the historical data in the historical parameter set.", "For example, the parameter set also includes a location identifier of the mobile terminal.", "The false data determining module further determines that the locations of the mobile terminal and the set of historical false terminal are within a preset range according to the location identifier.", "The set of historical false terminal includes one or more historical false terminals.", "For example, the data processing apparatus further includes a blocking module that blocks the false data; and a false terminal determining module that determines the mobile terminal as a false terminal.", "For example, the data processing apparatus also includes a response information sending module that, when the parameter set does not satisfy the preset condition, in response to the target data, sends response information to the mobile terminal.", "For example, the target data is target transaction data and the historical data is the historical transaction data.", "The present disclosure provides another data processing apparatus comprising: a target data generating module that generates target data, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal, the parameter set being a basis to determine that the target data is false data such that a server obtains a historical parameter set in historical data corresponding to the mobile terminal and, in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data, the historical parameter set including at least a historical posture parameter of the mobile terminal, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold; and a target data sending module that sends the target data to the server.", "For example, the data processing apparatus also includes a response information sending module that receives response information sent by the server.", "The response information is sent by the server to respond to the target data after the server determines that the parameter set does not satisfy the preset condition.", "For example, the target data is target transaction data and the historical data is the historical transaction data.", "The present disclosure also provides a data processing system including a mobile terminal and a server.", "The mobile terminal generates target data and sends the target data to the server.", "The server receives the target data sent by the mobile terminal, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal; obtains a historical parameter set in historical data corresponding to the mobile terminal, the historical parameter set including at least a historical posture parameter of the mobile terminal; and in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold.", "For example, the target data is target transaction data and the historical data is the historical transaction data.", "In the data processing method of the present disclosure, the server receives the target data carrying the parameter set sent by the mobile terminal.", "The parameter set includes at least a target posture parameter of the mobile terminal.", "In response to determining that the posture variation between the target posture parameter and the historical posture parameter is less than a preset variation threshold, the server determines that the parameter set satisfies the preset condition and determines the target data as false data.", "In this process, the amount of change in posture variation being smaller than the preset variation threshold indicates that the posture that the mobile terminal sends the target data hardly changes compared with the postures that the mobile terminal historically sends the target data to the server.", "As the posture of the mobile terminal is frequently changed during the process of normal use of the mobile terminal, the target data sent by the mobile terminal without posture change is regarded as false data.", "Then the mobile terminal that sends the false data is identified, thereby ensuring the fairness and efficiency of data processing.", "BRIEF DESCRIPTION OF THE DRAWINGS In order to more clearly illustrate the technical solutions in the embodiments of the present disclosure, the accompanying drawings briefly described embodiments or the prior art needed to be used in describing the embodiments.", "Apparently, the drawings in the following description represent only some of embodiments of the present disclosure.", "Those of ordinary skill in the art, without creative efforts, can derive other drawings from these drawings.", "FIG.", "1 is a flowchart illustrating a data processing method according to an example embodiment of the present disclosure; FIG.", "2 is a diagram illustrating posture parameters of a mobile terminal according to an example embodiment of the present disclosure; FIG.", "3 is a flowchart illustrating a method for determining the time interval according to an example embodiment of the present disclosure; FIG.", "4 is a flowchart illustrating another method for determining the time interval according to an example embodiment of the present disclosure; FIG.", "5 is a flowchart illustrating a method for determining that the locations of the mobile terminal and the set of historical false terminal are within a preset range according to the location identifier according to an example embodiment of the present disclosure; FIG.", "6 is a flowchart illustrating another method for determining that the locations of the mobile terminal and the set of historical false terminal are within a preset range according to the location identifier according to an example embodiment of the present disclosure; FIG.", "7 is a flowchart illustrating another method for determining that the locations of the mobile terminal and the set of historical false terminal are within a preset range according to the location identifier according to an example embodiment of the present disclosure; FIG.", "8 is a flowchart illustrating another method for determining that the locations of the mobile terminal and the set of historical false terminal are within a preset range according to the location identifier according to an example embodiment of the present disclosure; FIG.", "9 is a flowchart illustrating a method for determining that the parameter set satisfies the preset condition according to the historical parameter set according to an example embodiment of the present disclosure; FIG.", "10 is a flowchart illustrating another data processing method according to an example embodiment of the present disclosure; FIG.", "11 is a flowchart illustrating another data processing method according to an example embodiment of the present disclosure; FIG.", "12 is a diagram illustrating a data processing apparatus according to an example embodiment of the present disclosure; FIG.", "13 is a diagram illustrating another data processing apparatus according to an example embodiment of the present disclosure; FIG.", "14 is a diagram illustrating another data processing apparatus according to an example embodiment of the present disclosure; and FIG.", "15 is a diagram illustrating a data processing system according to an example embodiment of the present disclosure.", "DETAILED DESCRIPTION In conjunction with the drawings of the present disclosure, the technical solutions in the example embodiments of the present disclosure will be described below.", "Apparently, the described example embodiments are merely a portion of rather than all of the embodiments of the present disclosure.", "All other embodiments obtained by one of ordinary skill in the art without using creative efforts are within the scope of protection of the present disclosure.", "The present disclosure uses the comparison result or calculation result of the parameter set carried by the mobile terminal when sending the target data and the historical parameter set to determine whether the parameter set satisfies the preset condition, and further determine whether the sent target data is false data, thereby achieving the purpose of identifying whether the mobile terminal sends the false data.", "In the present disclosure, the target posture parameter of the mobile terminal is selected as the most important parameter as, in real life, there already exists using a PC by some means to control a plurality of mobile terminals, each mobile terminal using the corresponding account to send false data.", "Under this scenario, the plurality of mobile terminals is typically placed on a table or fixed to the wall, which is, in most cases, in a stationary state and their postures do not change much.", "If the posture parameters of the same mobile terminal in the adjacent two or more times when the mobile terminal sends the data to the server have no or little changes, the mobile terminal is regarded as having status change when sending data, which is further deemed as a false terminal sending false data that is controlled by a PC.", "Thus, the data sent by such mobile terminal is regarded as false data.", "Therefore, the present disclosure uses such characteristic to set the target posture parameter as the basis for identification basis.", "The parameter set includes at least the target posture parameter of the mobile terminal.", "The present disclosure provides a process of a data processing method.", "Referring to FIG.", "1, the data processing method is applied at the server, which includes: Step S102: the target data sent by the mobile terminal is received.", "The target data carries the parameter set.", "The parameter set includes at least the target posture parameter of the mobile terminal.", "The target posture parameter refers to a post parameter when the terminal sends the target data.", "The posture parameter may have multiple forms.", "For example, the posture parameter may be an angle between the terminal and the horizontal surface, such as 30°.", "Or, more strictly speaking, the parameter includes an angle α1 between the mobile terminal and the magnetic north, an angle of rotation β1 that the mobile terminal is rotated about the horizontal axis X, an angle of rotation γ1 that the mobile terminal is rotated about the horizontal axis Z, as shown in FIG.", "2.Step S104: the historical parameter set in historical data corresponding to the mobile terminal is obtained.", "The historical parameter set includes at least a historical posture parameter of the mobile terminal.", "The historical data corresponding to the mobile terminal is the data transmitted between the mobile terminal and the server during the data interaction process prior to the time that the mobile terminal sends the target data, and each time such data is transmitted a parameter set is carried.", "Such parameter set is defined as historical parameter set.", "The historical parameter set includes at least the historical posture parameter of the mobile terminal.", "The historical posture parameter in the historical parameter set may include only the last posture parameter when the mobile terminal sends data to the server in the last time, a preset number of posture parameters when the mobile terminal sends data to the server, or all posture parameters when the mobile terminal sends data to the server.", "Step S106: In response to determining that the parameter set satisfies a preset condition according to the historical parameter set, the target data is determined as false data.", "The process determining whether the parameter set satisfies the preset condition according to the historical parameter set is mainly achieved by analyzing or calculating the same type parameters in the two parameter sets.", "In this example embodiment, the parameter set includes at least the target posture parameter while the historical parameter set includes at least the historical posture parameter.", "The parameter set satisfying the preset condition includes at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold.", "If the posture parameter is an angle between the terminal and the horizontal surface, assuming that the target posture parameter is 30° and the historical posture parameter is 45° , the posture variation is 15°.", "Here, the present disclosure does not restrict which value is used as a minuend or subtrahend.", "Thus, the calculation result does not have a positive or negative sign and an absolute value is sued as long as such value reflects a difference between the two.", "Assuming that the preset variation threshold is 20°, as the posture variation is less than the preset variation threshold, the parameter set satisfies the present threshold and thus the target data is false data.", "If the target posture parameter includes an angle α1 between the mobile terminal and the magnetic north, an angle of rotation β1 that the mobile terminal is rotated about the horizontal axis X, an angle of rotation γ1 that the mobile terminal is rotated about the horizontal axis Z, and the historical posture parameter includes a historical angle α2 between the mobile terminal and the magnetic north, an angle of rotation β2 that the mobile terminal is rotated about the horizontal axis X, an angle of rotation γ2 that the mobile terminal is rotated about the horizontal axis Z, the calculation result from the angle variation Δ of the rotation of the three-dimension space √{square root over ((α−α2)2−(β−β2)2−(γ−γ2)2 )} is used as the posture variation.", "The preset variation threshold may be set as 10°.", "The present disclosure does not restrict to use the above formula to calculate the posture variation.", "For example, the differences between α1 and α2, β1 and β2, γ1 and γ2 are calculated and the average value of the three differences is used as the posture variation.", "In the data processing method of the present disclosure, the server receives the target data carrying the parameter set sent by the mobile terminal.", "The parameter set includes at least the target posture parameter when the mobile terminal sends the target data to the server.", "When the posture variation value between the target posture parameter and the historical posture parameter is less than the preset variation threshold, the posture that the mobile terminal sends the target data this time has almost no change from the posture that the mobile terminal historically sends the target data to the server.", "As the postures of the mobile terminal in normal use change frequently, the target data sent when the posture of the mobile terminal does not change is regarded as false data and the further the mobile terminal is identified as a false terminal.", "Further, the parameter set also includes a sending time of the target data.", "The parameter set satisfying the preset condition also includes that a time interval that the mobile terminal sends data is less than a predetermined time length.", "The time interval is determined by the sending time of the target data and the sending time of the historical data in the historical parameter set.", "The present techniques calculate the time interval that the mobile terminal sends the data as the determination condition.", "As criminal frequently controls the mobile terminal to make orders on the electronic business platform, if the time interval is small, the order frequency is higher, which conforms to the characteristic of sending false data.", "Thus, the present techniques use the time interval that the mobile terminal sends data being less than the preset time length as another determination condition, and use such condition together with the condition that the posture variation is less than the preset variation threshold.", "When both conditions are met, the parameter set is determined to satisfy the preset condition and thus the target6 data is the false data.", "In the example embodiment, the process of determining the time interval may be as shown in FIG.", "3, which includes: Step S302: the last time that the mobile terminal sends data is determined as the sending time of the historical data.", "Suppose the last time that the mobile terminal sends data is t1 and the sending time of the target data is t2.Step S304: The time difference between the sending time of the target data and the sending time of the historical data is determined as the time interval.", "δT=t2−t1 The present disclosure is not limited to determine the time interval only by the method shown in FIG.", "3.The method as shown in FIG.", "4 may also be used, which includes: Step S402: when there are multiple sending times of the historical data, the time intervals of sending times of the adjacent historical data are calculated respectively.", "Step S404: the time interval between the sending time of the target data and the last time that the mobile terminal sends data is calculated.", "Step S406: the average value of all time intervals is calculated.", "The average value is used as the time interval that the mobile terminal sends data.", "The present disclosure does not restrict to use the above two methods to obtain the time interval.", "Any method that calculates the time interval value of the frequency that the mobile terminal sends data is with the protection scope of the present disclosure.", "Compared with the method shown in FIG.", "3, the method shown in FIG.", "4 uses the average value to determine the time interval, which more accurately reflects the frequency that the mobile terminal sends the data within a period of time.", "Based on any of the above example embodiments, the parameter set of the present disclosure may also include a location identifier of the mobile terminal.", "The parameter set satisfying the preset condition also includes that the locations of the mobile terminal and the set of historical false terminal are within a preset range according to the location identifier.", "The set of historical false terminal includes one or more historical false terminals.", "When the set of historical false terminal includes multiple historical false terminals, the distance between adjacent historical false terminals is less than a preset distance threshold.", "The present disclosure uses the location relationship between the mobile terminal and the set of historical false terminal.", "During the process of using a PC machine to control multiple mobile terminals to send false data, multiple mobile terminals need to be connected with the PC through the control cable or wireless local area network.", "Thus, the locations of the multiple mobile terminals are close within a short range.", "Thus, when some historical false terminals are determined and used as the set of historical false terminal, if the locations of the one particular mobile terminals and the historical false terminals in the set of historical false terminal are within a preset range, the locations of the mobile terminal and the historical false terminal are deemed close, and thus the mobile terminal is also deemed as a terminal that sends false data.", "In the example embodiment, the location identifier includes latitude and longitude data, a base station identifier, and/or a WIFI hotspot identifier of the mobile terminal when the mobile terminal sends the target data.", "When the location identifier is the latitude and longitude data when the terminal sends data, the location identifier included in the historical parameter set includes the latitude and longitude data when the false terminal in the set of historical false terminal sends data.", "Then, the determining process that the locations of the mobile terminal and the set of historical false terminal are within a preset range according to the location identifier may be as shown in FIG.", "5, which includes: Step S502: the latitude and longitude data of the set of historical false terminal is determined.", "Step S504: the difference between the latitude and longitude data when the mobile terminal sends the target data and the latitude and longitude data of the set of historical false terminal is calculated.", "Step S506: whether the distance is less than a preset distance threshold is determined.", "If a result is positive, step S508 is performed; if not, step S510 is performed.", "The preset distance threshold may be set to 5 cm, or according to actual situation.", "Step S508: the locations of the mobile terminal and the set of historical false terminal are determined within a preset range.", "Step S510: the locations of the mobile terminal and the set of historical false terminal are determined not within a preset range.", "In this example embodiment, the latitude and longitude data of the set of historical false terminal may be the latitude and longitude data of a predetermined false terminal, or the latitude and longitude data the centers of the shapes covering the various historical false terminals in the set of historical false terminal.", "Such shape may be circle, square, or other shapes as long as they cover all historical false terminals and their centers are ascertainable, which are within the protection scope of the present disclosure.", "When the location identifier is the base station identifier of the base station when the terminal sends data, the location identifier included in the historical parameter set includes the base station identifier of the base station when the false terminal in the set of historical false terminal sends data.", "Then, the determining process that the locations of the mobile terminal and the set of historical false terminal are within a preset range according to the location identifier may be as shown in FIG.", "6, which includes: Step S602: the base station identifier of the set of historical false terminal is determined.", "The base station identifier is CGI.", "Step S604: whether the base station identifier of the base station when the mobile terminal sends target data is consistent with the base station identifier of the base station when the set of historical false terminal sends data is determined.", "If the result is positive, step S606 is performed; otherwise, step S608 is performed.", "Step S606: the locations of the mobile terminal and the set of historical false terminal are determined within a preset range.", "Step S608: the locations of the mobile terminal and the set of historical false terminal are determined not within a preset range.", "When the location identifier is the WIFI hot spot identifier of the WIFI hot spot through which the mobile terminal sends data, the location identifier included in the historical parameter sets includes the WIFI hot spot identifier of the WIFI hot spot through which the false terminal in the set of historical false terminal sends data.", "Then, the determining process that the locations of the mobile terminal and the set of historical false terminal are within a preset range according to the location identifier may be as shown in FIG.", "6, which includes: Step S702: the WIFI hot spot identifier of the set of historical false terminal is determined.", "The WIFI hot spot identifier is the SSID or BSSID.", "Step S704: whether the WIFI hot spot identifier of the WIFI hot spot through which the mobile terminal sends target data is consistent with the WIFI hot spot identifier of the WIFI hot spot through which the set of historical false terminal sends data is determined.", "If a result is positive, step S706 is performed; if not, step S708 is performed.", "Step S706: the locations of the mobile terminal and the set of historical false terminal are determined within a preset range.", "Step S708: the locations of the mobile terminal and the set of historical false terminal are determined not within a preset range.", "The above example embodiment describes from the perspective that the location identifier includes only one form.", "In an actual application, the location identifier may include a combination of any two or all of the above three forms.", "Under such situation, the present techniques consider the determination result of the three situations comprehensively when determining whether locations of the mobile terminal and the set of historical false terminal are within the preset range.", "For example, when the location identifier includes the latitude and longitude data and the base station identifier when the mobile terminal sends the target data, the determination process may be as shown in FIG.", "8, which includes: Step S802: the base station identifier of the set of historical false terminal is determined.", "Step S804: whether the base station identifier of the base station through which the mobile terminal sends target data is consistent with the base station identifier of the base station through which the set of historical false terminal sends data is determined.", "If the result is positive, step S806 is performed; otherwise, step S814 is performed.", "Step S806: the latitude and longitude data of the set of historical false terminal is determined.", "Step S808: the difference between the latitude and longitude data when the mobile terminal sends the target data and the latitude and longitude data of the set of historical false terminal is calculated.", "Step S810: whether the distance is less than a preset distance threshold is determined.", "If a result is positive, step S812 is performed; if not, step S814 is performed.", "Step S812: the locations of the mobile terminal and the set of historical false terminal are determined within a preset range.", "Step S814: the locations of the mobile terminal and the set of historical false terminal are determined not within a preset range.", "In the example embodiment as shown in FIG.", "8, the location identifier includes longitude and latitude data and a base station identifier when the mobile terminal sends the target data.", "Analysis of these two parameters reveals that the latitude and longitude data is a more direct determination parameter, and the base station identity is a parameter indirectly judged by whether the mobile terminal is in the coverage of the base station.", "In addition, the coverage of the base station is a large area, and latitude and longitude data is a very specific parameter value.", "In combination with the characteristics of these two parameters, in the example embodiment as shown in FIG.", "8, the present techniques firstly determine whether the base station identifier of the base station when the mobile terminal sends the target data is consistent with the base station identifier of the base station of the set of historical false terminal to determine whether the mobile terminal and the set of historical false terminal are within the coverage of the same base station.", "If the two are inconsistent, the difference between the two are deemed far away and are directly determined not within the preset range.", "Thus, there is no need to perform the following calculation process.", "If the two are consistent, the present techniques further determine whether the distance between the two is within the preset range according to the latitude and longitude data to determine whether the two are in a very close state.", "That is, the locations of the mobile terminal and the set of historical fake terminal are determined to be within the preset range only when both two determination conditions are satisfied, which improves the accuracy and reliability of the process.", "In this example embodiment, the location identifier only includes the longitude and latitude data and the base station identifier of the base station when the mobile terminal sends the target data as an example.", "The present disclosure does not restrict to perform according to the above process.", "Two determination conditions may also be determined simultaneously.", "When the determination result is that the base station identifiers are consistent and the distance is less than the preset distance value, the locations of the mobile terminal and the set of historical false terminal are within a preset range.", "When the location identifier includes the latitude and longitude data, the base station identifier, and the WIFI hotspot identifier of the mobile terminal when the mobile terminal sends the target data, the sequence of the three determination processes may also be set according to the actual situation.", "Or, the sequence of the three determination processes is not limited.", "The three determination processes may be determined simultaneously.", "When the base station identifiers are consistent, the WIFI hot spot identifiers are consistent, and the distance is less than the preset distance threshold, the locations of the mobile terminal and the set of historical false terminal are determined to be within the preset range.", "Or, if any two conditions are met, the locations of the mobile terminal and the set of historical false terminal are determined to be within the preset range.", "FIG.", "8 is just an illustration example and should not be used to restrict the detailed implementation process.", "Certainly, the present disclosure does not limit the location identifier to only the above three forms, and may also use location information when the mobile terminal sends the target data by using GPRS.", "Based on the foregoing example embodiment, the parameter set disclosed by the present disclosure includes the target posture parameter, the sending time of the target data, and/or the location identifier of the mobile terminal.", "The target posture parameter may be arbitrarily combined with the other two parameters.", "For example, the parameter set includes the target posture parameter and the sending time of the target data.", "Alternatively, the parameter includes the target posture parameter, the sending time of the target data, and/or the location identifier of the mobile terminal.", "Alternatively, the parameter set includes the target posture parameter and the location identifier of the mobile terminal.", "When the parameter set includes different contents, the process of determining that the parameter set satisfies the preset condition according to the historical parameter set is also different.", "In this example embodiment, the parameter set includes the target posture parameter, the sending time of the target data, and the location identifier of the mobile terminal, which is used as an example to illustrate the process.", "The specific process may be as shown in FIG.", "9, which includes: Step S902: whether the posture variance between the target posture parameter and the historical posture parameter in the historical parameter set is less than the preset variation threshold.", "If a result is positive, step S904 is performed; otherwise, step S910 is performed.", "The historical posture parameter includes an angle between the terminal and the horizontal surface, such as 30°, or more strictly speaking, an angle α1 between the mobile terminal and the magnetic north, an angle of rotation β1 that the mobile terminal is rotated about the horizontal axis X, an angle of rotation γ1 that the mobile terminal is rotated about the horizontal axis Z.", "Step S904: whether the time interval that the mobile terminal sends data is less than the preset time length is determined.", "If a result is positive, step S906 is performed; otherwise, step S910 is performed.", "Such process may refer to the example embodiment as shown in FIG.", "2 or FIG.", "3.Step S906: whether the locations of the mobile terminal and the set of historical false terminal are within the preset range is determined.", "If a result is positive, step S908 is performed; otherwise, step S910 is performed.", "Such step may refer to the example embodiments as shown from FIGS.", "3-7.Step S908: the parameter set satisfies the preset condition.", "Step S910: the parameter set does not satisfy the preset condition.", "Similarly, the present disclosure only uses the parameter set that includes the posture parameter set, the sending time of the target data, and the location identifier of the mobile terminal as an example to illustrate to process determining that the parameter set satisfies the preset condition according to the historical parameter set, and does not limit to use the above method to implement the process determining that the parameter set satisfies the preset condition according to the historical parameter set.", "The sequence of the determination process of the three parameters is not determined.", "The three parameters may be determined simultaneously.", "When all of the parameters satisfy condition, or two or one parameter satisfies condition, the parameter set is determined to satisfy the preset condition.", "In addition, the present disclosure does not limit that the parameter set only includes the above three parameters.", "The parameter set may also include the merchant identification or the product identification in the target data.", "The present techniques determine whether the occurrence times of the merchant identification or the product identification are more than the preset number threshold.", "In a false process, the same merchant or product may be repeatedly visited or purchased for multiple time.", "When the occurrence times of the merchant identification or the product identification in the target data are more than the preset number threshold, such data is determined as false data.", "In the above method disclosed by the present disclosure, after the target data is determined as false data, the method also includes the following processing process, as shown in FIG.", "10, which includes: Step S1002: the false data is blocked.", "The false data may be blocked, not processed, or deleted.", "Step S1004: the false terminal is determined as the false terminal.", "The mobile terminal sending the false data is defined as the false terminal so that when the data sent by the false terminal is received again, such data is directly determined as the false data.", "Alternatively, such terminal is added into the set of historical false terminal to help identify false data in the following data processing.", "After the parameter set is determined as not satisfying the preset condition, in response to the target data, the response information is sent to the mobile terminal.", "The present disclosure also provides a data processing method applied at the mobile terminal corresponding to the above data processing method, as shown in FIG.", "11, which includes: Step S1102: the target data is generated.", "The target data carries a parameter set.", "The parameter set includes at least a target posture parameter of the mobile terminal.", "The parameter set is a basis to determine that the target data is false data such that a server obtains a historical parameter set in historical data corresponding to the mobile terminal and, in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data.", "The historical parameter set includes at least a historical posture parameter of the mobile terminal.", "The parameter set satisfying the preset condition includes at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold.", "In addition, the parameter set also includes a sending time of the target data and/or a location identifier of the mobile terminal.", "The parameter set may also include the merchant identification and/or product identification in the target data.", "The present techniques determine whether the occurrence times of the merchant identification or the product identification are more than the preset number threshold.", "The location identifier includes, but is not limited to, the longitude and latitude data, the base station identifier of the base station, and the WIFI hot spot identification of the WIFI hot spot when the mobile terminal sends the target data.", "Certainly, the present disclosure does not limit the location identifier to only the above three forms, and may also use the location information when the mobile terminal sends the target data by using GPRS.", "Step S1104: the target data is sent to the server.", "In the data processing method of the present disclosure, the mobile terminal sends the parameter set together with the target data.", "The parameter set includes at least the target posture parameter when the mobile terminal sends the target data to the server so that the server determines that the target data is false data by using the parameter set.", "Further, the method also includes: Step S1106: the response information sent by the server is received when the parameter set does not satisfy the preset condition according to the historical parameter set.", "In the example embodiments as shown from FIGS.", "1-11, the target data may be target transaction data.", "The historical data may be historical transaction data.", "That is, when the mobile terminal conducts transactions with the server, the server determines whether the transaction data sent by the mobile terminal is false transaction data.", "The present disclosure provides a data processing apparatus 1200 whose structure as shown in FIG.", "12.The data processing apparatus 1200 includes one or more processor(s) 1202 or data processing unit(s) and memory 1204.The data processing apparatus 1200 may further include one or more input/output interface(s) 1206 and one or more network interface(s) 1208.The memory 1204 is an example of computer readable media.", "Computer readable media, including both permanent and non-permanent, removable and non-removable media, may be stored by any method or technology for storage of information.", "The information can be computer readable instructions, data structures, modules of programs, or other data.", "Examples of computer storage media include, but are not limited to, phase change memory (PRAM), static random access memory (SRAM), dynamic random access memory (DRAM), other types of random access memory (RAM), read only memory Such as ROM, EEPROM, flash memory or other memory technology, CD-ROM, DVD, or other optical storage, Magnetic cassettes, magnetic tape magnetic tape storage or other magnetic storage devices, or any other non-transitory medium, may be used to store information that may be accessed by a computing device.", "As defined herein, computer-readable media do not include non-transitory transitory media such as modulated data signals and carriers.", "The memory 1204 may store therein a plurality of modules or units including a target data receiving module 1210, a historical parameter set obtaining module 1212, and a false data determining module 1214.The target data receiving module 1210 receives target data sent by a mobile terminal, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal.", "The target posture parameter refers to a post parameter when the terminal sends the target data.", "The posture parameter may have multiple forms.", "For example, the posture parameter may be an angle between the terminal and the horizontal surface, such as 30°.", "Or, more strictly speaking, the parameter includes an angle α1 between the mobile terminal and the magnetic north, an angle of rotation β1 that the mobile terminal is rotated about the horizontal axis X, an angle of rotation γ1 that the mobile terminal is rotated about the horizontal axis Z, as shown in FIG.", "2.If the posture parameter is an angle between the terminal and the horizontal surface, assuming that the target posture parameter is 30° and the historical posture parameter is 45°, the posture variation is 15°.", "Here, the present disclosure does not restrict which value is used as a minuend or subtrahend.", "Thus, the calculation result does not have a positive or negative sign and an absolute value is sued as long as such value reflects a difference between the two.", "Assuming that the preset variation threshold is 20°, as the posture variation is less than the preset variation threshold, the parameter set satisfies the present threshold and thus the target data is false data.", "If the target posture parameter includes an angle α1 between the mobile terminal and the magnetic north, an angle of rotation β1 that the mobile terminal is rotated about the horizontal axis X, an angle of rotation γ1 that the mobile terminal is rotated about the horizontal axis Z, and the historical posture parameter includes a historical angle α2 between the mobile terminal and the magnetic north, an angle of rotation β2 that the mobile terminal is rotated about the horizontal axis X, an angle of rotation γ2 that the mobile terminal is rotated about the horizontal axis Z, the calculation result from the angle variation Δ of the rotation of the three dimension space √{square root over ((α−α2)2−(β−β2)2−(γ−γ2)2 )} is used as the posture variation.", "The preset variation threshold may be set as 10°.", "The present disclosure does not restrict to use the above formula to calculate the posture variation.", "For example, the differences between α1 and α2, β1 and β2, γ1 and γ2 are calculated and the average value of the three differences is used as the posture variation.", "The historical parameter set obtaining module 1212 obtains a historical parameter set in historical data corresponding to the mobile terminal, the historical parameter set including at least a historical posture parameter of the mobile terminal.", "The historical data corresponding to the mobile terminal is the data transmitted between the mobile terminal and the server during the data interaction process prior to the time that the mobile terminal sends the target data, and each time such data is transmitted a parameter set is carried.", "Such parameter set is defined as historical parameter set.", "The historical parameter set includes at least the historical posture parameter of the mobile terminal.", "The historical posture parameter in the historical parameter set may include only the last posture parameter when the mobile terminal sends data to the server in the last time, a preset number of posture parameters when the mobile terminal sends data to the server, or all posture parameters when the mobile terminal sends data to the server.", "The false data determining module 1214, in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold.", "The parameter set may also include a sending time of the target data.", "The false data determining module 1214 further determines the time interval that the mobile terminal sends data is less than a preset time length.", "The time interval is determined by the sending time of the target data and the sending time of the historical data in the historical parameter set.", "The last time that the mobile terminal sends data may be determined as the sending time of the historical data.", "Suppose the last time that the mobile terminal sends data is t1 and the sending time of the target data is t2, the time difference between the sending time of the target data and the sending time of the historical data is determined as the time interval.", "Alternatively, when there are multiple sending times of the historical data, the time intervals of adjacent sending times of the historical data are calculated respectively.", "The time interval between the sending time of the target data and the last time that the mobile terminal sends data is calculated.", "The average value of all time intervals is calculated.", "The average value is used as the time interval that the mobile terminal sends data.", "Based on the foregoing example embodiment, the parameter set may also include the location identifier of the mobile terminal.", "The false data determining module 1214 further determines whether the locations of the mobile terminal and set of historical false terminal are within the preset range.", "The set of historical false terminal includes one or more historical false terminals.", "In the example embodiment, the location identifier includes latitude and longitude data, a base station identifier, and/or a WIFI hotspot identifier of the mobile terminal when the mobile terminal sends the target data.", "The determining process that the locations of the mobile terminal and the set of historical false terminal are within a preset range according to the location identifier includes: determining latitude and longitude data of the set of historical false terminal; calculating a distance between the latitude and longitude data of the mobile terminal that sends the target data and the latitude and longitude data of the set of historical false terminal; in response to determining that the distance is less than a preset distance threshold, determining that the locations of the mobile terminal and the set of historical false terminal are within the preset range; determining the base station identifier of the set of historical false terminal; in response to determining that the base station identifier of the base station that the mobile terminal uses to send the target data coincides with the base station identifier of the set of historical false terminal, determining that the locations of the mobile terminal and the set of historical false terminal are within the preset range; or determining a WIFI hot spot identifier of the set of historical false terminal; in response to determining that the WIFI hot spot identifier of the WIFI hot spot that the mobile terminal uses to send the target data coincides with the WIFI hot spot of the set of historical false terminal, determining that the locations of the mobile terminal and the set of historical false terminal are within the preset range.", "The detailed process may refer to the example embodiments as shown in FIGS.", "3-7.Alternatively, any of the above two or three determination processes may be combined to set the sequence of determination processes to determine subsequently to obtain the result.", "Alternatively, the sequence of the determination processes is not limited and the determination processes may be conducted simultaneously.", "When the base station identifiers of the mobile terminal and the set of historical false terminal are consistent, the WIFI hot spot identifiers of the mobile terminal and the set of historical false terminal are consistent, and the distance between the mobile terminal and the set of historical false terminal is less than the preset distance threshold, the locations of the mobile terminal and the set of historical false terminal are within the present range.", "Or if any two of the conditions are satisfied, the locations of the mobile terminal and the set of historical false terminal are within the present range.", "As shown from the above example embodiments, the parameter set disclosed by the present disclosure includes the target posture parameter, the sending time of the target data, and/or the location identifier of the mobile terminal.", "The target posture parameter may be arbitrarily combined with the other two parameters.", "For example, the parameter set includes the target posture parameter and the sending time of the target data.", "Alternatively, the parameter set includes the target posture parameter, the sending time of the target data, and the location identifier of the mobile terminal.", "Alternatively, the parameter set includes the target posture parameter and the location identifier of the mobile terminal.", "When the contents included in the parameter set are different, the process determining that the parameter set satisfies the preset condition according to the historical parameter set is also different, which may refer to the process as shown in FIG.", "9.Further, the structure of a data processing apparatus 1300 may be as shown in FIG.", "13.In addition to the modules as shown in FIG.", "12, the data processing apparatus 1300 as shown in FIG.", "13 may further includes the following modules stored on memory 1204: a blocking module 1302 that blocks the false data; a false terminal determining module 1304 that determines the mobile terminal as a false terminal; and a response information sending module 1306 that, when the parameter set does not satisfy the preset condition, in response to the target data, sends response information to the mobile terminal.", "The data processing apparatus disclosed by the present disclosure applies at the server, which receives the target data carrying the parameter set sent by the mobile terminal.", "The parameter set includes at least the target posture parameter when the mobile terminal sends the target data to the server.", "When the posture variation value between the target posture parameter and the historical posture parameter is less than the preset variation threshold, the posture that the mobile terminal sends the target data this time has almost no change from the posture that the mobile terminal historically sends the target data to the server.", "As the postures of the mobile terminal in normal use change frequently, the target data sent when the posture of the mobile terminal does not change is regarded as false data.", "Correspondingly, the present disclosure provides a data processing apparatus 1400 applied at the mobile terminal, whose structure may be as shown in FIG.", "14.The data processing apparatus 1400 includes one or more processor(s) 1402 or data processing unit(s) and memory 1404.The data processing apparatus 1400 may further include one or more input/output interface(s) 1406 and one or more network interface(s) 1408.The memory 1404 is an example of computer readable media.", "The memory 1404 may store therein a plurality of modules or units including a target data generating module 1410 and a target data sending module 1412.The target data generating module 1410 generates target data, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal, the parameter set being a basis to determine that the target data is false data such that a server obtains a historical parameter set in historical data corresponding to the mobile terminal and, in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data, the historical parameter set including at least a historical posture parameter of the mobile terminal, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold.", "The target data sending module 1412 sends the target data to the server.", "Further, the data processing apparatus 1400 may also include a response information receiving module 1414 stored on memory 1404 that receives response information sent by the server.", "The response information is sent by the server to respond to the target data after the server determines that the parameter set does not satisfy the preset condition.", "The data processing apparatus at the mobile terminal may cooperate with the data processing apparatus at the server to achieve the purpose of identifying false data.", "In the example embodiments as shown in FIGS.", "12-14, the target data may be target transaction data.", "The historical data may be historical transaction data.", "That is, when the mobile terminal conducts transactions with the server, the server determines whether the transaction data sent by the mobile terminal is false transaction data.", "The present disclosure also provides a data processing system.", "As shown in FIG.", "15, the data processing process includes the mobile terminal 1502 and the server 1504.The mobile terminal 1502 generates target data and sends the target data to the server.", "The mobile terminal may be a cell phone, a tablet.", "This example embodiment uses the cell phone as an example.", "The server 1504 receives the target data sent by the mobile terminal, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal; obtains a historical parameter set in historical data corresponding to the mobile terminal, the historical parameter set including at least a historical posture parameter of the mobile terminal; and in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data.", "The parameter set satisfying the preset condition includes at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold.", "The operation process of the data processing system may refer to the above method embodiments.", "In the data processing system provided by the present disclosure, the mobile terminal sends the parameter set together with the target data so that the server uses the historical parameter set in the historical data to determine whether the parameter set satisfies the preset condition.", "When the parameter set satisfies the preset condition, the target data is determined as false data, thereby ensuring the fairness and effectiveness of the data processing process.", "In the example embodiment as shown in FIG.", "15, the target data may be target transaction data.", "The historical data may be historical transaction data.", "That is, when the mobile terminal conducts transactions with the server, the server determines whether the transaction data sent by the mobile terminal is false transaction data.", "The functions described in the methods of the example embodiments may be stored in a computing device readable storage medium if implemented in the form of a software functional unit and sold or used as an independent product.", "Based on such understanding, the part of the example embodiments of the present disclosure that makes contributions to the conventional techniques or the part of the technical solution may be embodied in the form of a software product stored in a storage medium and including several instructions for causing a computing device (which may be a personal computer, a server, a mobile computing device, or a network device) to perform all or part of the steps of the method described in each embodiment of the present disclosure.", "The foregoing storage medium includes various media capable of storing program code such as a USB flash disk, a removable hard disk, a read-only memory (ROM), a random-access memory (RAM), a magnetic disk, or an optical disk.", "The example embodiments in the present disclosure are described in a progressive manner.", "Each embodiment focuses on differences from other embodiments, and the same or similar parts among the embodiments may refer to each other.", "The above description of the disclosed example embodiments enables those skilled in the art to make or use the present disclosure.", "Various modifications to these example embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be embodied in other embodiments without departing from the spirit or scope of the present disclosure.", "Therefore, the present disclosure is not limited to these example embodiments shown herein, but rather should cover the broadest scope consistent with the principles and novel features disclosed herein.", "Tie present disclosure may further be understood with clauses as follows.", "Clause 1.A data processing method comprising: receiving target data sent by a mobile terminal, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal; obtaining a historical parameter set in historical data corresponding to the mobile terminal, the historical parameter set including at least a historical posture parameter of the mobile terminal; and in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determining that the target data is false data, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold.", "Clause 2.The method of clause 1, wherein: the target posture parameter includes: an angle α1 between the mobile terminal and a magnetic north; an angle of rotation β1 that the mobile terminal is rotated about a horizontal axis X; and an angle of rotation γ1 that the mobile terminal is rotated about a horizontal axis Z; the historical posture parameter includes: a historical angle α2 between the mobile terminal and the magnetic north; an angle of rotation β2 that the mobile terminal is rotated about the horizontal axis X; and an angle of rotation γ2 that the mobile terminal is rotated about the horizontal axis Z; and the posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is determined by using a value calculated from a formula √{square root over ((α−α2)2−(β−β2)2−(γ−γ2)2 )}.", "Clause 3.The method of clause 1, wherein: the parameter set further includes a sending time of the target data; and the parameter set satisfying the preset condition further includes that a time interval that the mobile terminal sends data is less than a predetermined time length, the time interval being determined by the sending time of the target data and a sending time of historical data in the historical parameter set.", "Clause 4.The method of clause 3, wherein a process to determine the time interval includes: using a latest time that the mobile terminal sends data as the sending time of the historical data; and determining a time difference between the sending time of the target data and the sending time of the historical data as the time interval.", "Clause 5.The method of clause 1 or 3, wherein: the parameter set further includes a location identifier of the mobile terminal; and the parameter set satisfying the preset condition further includes that locations of the mobile terminal and a set of historical false terminal are within a preset range according to the location identifier, the set of historical false terminal including one or more historical false terminals.", "Clause 6.The method of clause 5, wherein: when the set of historical false terminal includes multiple historical false terminals, a distance between adjacent historical false terminals is less than a preset distance threshold.", "Clause 7.The method of clause 6, wherein: the location identifier includes latitude and longitude data, a base station identifier, and/or a WIFI hotspot identifier of the mobile terminal when the mobile terminal sends the target data; and a process determining that locations of the mobile terminal and the set of historical false terminal are within the preset range according to the location identifier includes: determining latitude and longitude data of the set of historical false terminal; calculating a distance between the latitude and longitude data of the mobile terminal that sends the target data and the latitude and longitude data of the set of historical false terminal; in response to determining that the distance is less than a preset distance threshold, determining that the locations of the mobile terminal and the set of historical false terminal are within the preset range; determining the base station identifier of the set of historical false terminal; in response to determining that the base station identifier of the base station that the mobile terminal uses to send the target data coincides with the base station identifier of the set of historical false terminal, determining that the locations of the mobile terminal and the set of historical false terminal are within the preset range; or determining a WIFI hot spot identifier of the set of historical false terminal; in response to determining that the WIFI hot spot identifier of the WIFI hot spot that the mobile terminal uses to send the target data coincides with the WIFI hot spot of the set of historical false terminal, determining that the locations of the mobile terminal and the set of historical false terminal are within the preset range.", "Clause 8.The method of clause 7, wherein the latitude and longitude data of the set of historical false terminal includes latitude and longitude data of center points of shapes of various historical false terminals in the set of historical false terminal.", "Clause 9.The method of clause 7, wherein: the base station identifier is a Cell Global Identifier (CGI); and the WIFI hotspot identifier is a service set identifier (SSID) or a basic service set identification (BS SID).", "Clause 10.The method of clause 1, further comprising: after, in response to determining that the parameter set satisfies the preset condition according to the historical parameter set, determining that the target data is false data, blocking the false data; and determining that the mobile terminal is a false terminal.", "Clause 11.The method of clause 1, further comprising: in response to determining that the parameter set does not satisfy the preset condition, in response to the target data, sending response information to the mobile terminal.", "Clause 12.The method of any of clauses 1-11, wherein: the target data is target transaction data; and the historical data is the historical transaction data.", "Clause 13.A data processing method comprising: generating target data, the target data carrying a parameter set, the parameter set including at least a target posture parameter of a mobile terminal, the parameter set being a basis to determine that the target data is false data such that a server obtains a historical parameter set in historical data corresponding to the mobile terminal and, in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data, the historical parameter set including at least a historical posture parameter of the mobile terminal, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold; and sending the target data to the server.", "Clause 14.The method of clause 13, wherein the parameter set also includes a sending time of the target data and/or a location identifier of the mobile terminal.", "Clause 15.The method of clause 13, further comprising: receiving response information sent by the server, wherein: the response information is sent by the server to respond to the target data after the server determines that the parameter set does not satisfy the preset condition.", "Clause 16.The method of any of clauses 13-15, wherein: the target data is target transaction data; and the historical data is the historical transaction data.", "Clause 17.A data processing apparatus comprising: a target data receiving module that receives target data sent by a mobile terminal, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal; a historical parameter set obtaining module that obtains a historical parameter set in historical data corresponding to the mobile terminal, the historical parameter set including at least a historical posture parameter of the mobile terminal; and a false data determining module that, in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold.", "Clause 18.The apparatus of clause 17, wherein: the parameter set further includes a sending time of the target data; and the false data determining module further determines ae time interval that the mobile terminal sends data is less than a preset time length, the time interval being determined by the sending time of the target data and a sending time of the historical data in the historical parameter set.", "Clause 19.The apparatus of clause 18, wherein: the parameter set further includes a location identifier of the mobile terminal; and the false data determining module further determines that locations of the mobile terminal and the set of historical false terminal are within a preset range according to the location identifier, the set of historical false terminal including one or more historical false terminals.", "Clause 20.The apparatus of clause 17, further comprising: a blocking module that blocks the false data; and a false terminal determining module that determines the mobile terminal as a false terminal.", "Clause 21.The apparatus of clause 17, further comprising: a response information sending module that, when the parameter set does not satisfy the preset condition, in response to the target data, sends response information to the mobile terminal.", "Clause 22.The apparatus of any of clauses 17-21, wherein: the target data is target transaction data; and the historical data is the historical transaction data.", "Clause 23.A data processing apparatus comprising: a target data generating module that generates target data, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal, the parameter set being a basis to determine that the target data is false data such that a server obtains a historical parameter set in historical data corresponding to the mobile terminal and, in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data, the historical parameter set including at least a historical posture parameter of the mobile terminal, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold; and a target data sending module that sends the target data to the server.", "Clause 24.The apparatus of clause 23, further comprising: a response information sending module that receives response information sent by the server, the response information being sent by the server to respond to the target data after the server determines that the parameter set does not satisfy the preset condition.", "Clause 25.The apparatus of clause 23 or 24, wherein: the target data is target transaction data; and the historical data is the historical transaction data.", "Clause 26.A data processing system comprising: a mobile terminal; and a server, wherein: the mobile terminal generates target data and sends the target data to the server; and the server receives the target data sent by the mobile terminal, the target data carrying a parameter set, the parameter set including at least a target posture parameter of the mobile terminal; obtains a historical parameter set in historical data corresponding to the mobile terminal, the historical parameter set including at least a historical posture parameter of the mobile terminal; and in response to determining that the parameter set satisfies a preset condition according to the historical parameter set, determines that the target data is false data, the parameter set satisfying the preset condition including at least that a posture variation between the target posture parameter in the parameter set and the historical posture parameter in the historical parameter set is less than a preset variation threshold.", "Clause 27.The system of clause 26, wherein: the target data is target transaction data; and the historical data is the historical transaction data." ] ]
Patent_15875954
[ [ "Method for Producing a Semiconductor Component and a Semiconductor Component", "A method for producing a plurality of semiconductor components and a semiconductor component are disclosed.", "In an embodiment the component includes a light transmissive carrier, a semiconductor body disposed on the light transmissive carrier, the semiconductor body including a first semiconductor layer, a second semiconductor layer and an active region being arranged between the first semiconductor layer and the second semiconductor layer, wherein the semiconductor body includes a first patterned main surface facing the light transmissive carrier and a second main surface facing away from the carrier and a contact structure including a first contact area and a second contact area arranged on the second main surface, wherein the second contact area is electrically connected to the second semiconductor layer, and wherein the contact structure comprises a via extending from the second main surface throughout the second semiconductor layer and the active region into the first semiconductor layer." ], [ "1.A semiconductor component comprising: a light transmissive carrier; a semiconductor body disposed on the light transmissive carrier, the semiconductor body comprising a first semiconductor layer, a second semiconductor layer and an active region being arranged between the first semiconductor layer and the second semiconductor layer, wherein the semiconductor body comprises a first patterned main surface facing the light transmissive carrier and a second main surface facing away from the carrier; a contact structure comprising a first contact area and a second contact area arranged on the second main surface, wherein the second contact area is electrically connected to the second semiconductor layer, and wherein the contact structure comprises a via, the via being electrically connected to the first contact area and extending from the second main surface throughout the second semiconductor layer and the active region into the first semiconductor layer; and an insulating layer covering a vertical surface of the semiconductor body, wherein the insulating layer comprises a tether or a remnant of the tether, and wherein the semiconductor component is free of a growth substrate.", "2.The semiconductor component according to claim 1, wherein the tether or the remnant of the tether is arranged sideways from the semiconductor body and is embedded in a connecting layer fixing the semiconductor body to the light transmissive carrier.", "3.The semiconductor component according to claim 1, further comprising a first mirror layer and a second mirror layer, wherein the first mirror layer is arranged on a side of the semiconductor body facing the second main surface, wherein the second mirror layer is embedded into the light transmissive carrier, wherein the second mirror layer is arranged sideways from the semiconductor body, and wherein the first mirror layer and the second mirror layer do not overlap.", "4.The semiconductor component according to claim 1, wherein the active region is configured to generate electromagnetic radiation during operation of the semiconductor component.", "5.The semiconductor component according to claim 1, wherein phosphor particles are disposed within the light transmissive carrier.", "6.The semiconductor component according to claim 1, wherein phosphor particles are in a layer disposed on the light transmissive carrier.", "7.A device comprising: a plurality of the semiconductor components according to claim 1, wherein the light transmissive carriers of the semiconductor components are formed as a single common light transmissive carrier.", "8.The semiconductor component according to claim 1, wherein the light transmissive carrier is an interposer or a final board, wherein, during operation of the semiconductor component, the active region is configured to generate electromagnetic radiation which is coupled out from the semiconductor component at a surface of the light transmissive carrier, the surface being remote from the semiconductor body.", "9.The semiconductor component according to claim 1, wherein the tether or the remnant of the tether is embedded in a connecting layer which mechanically fixes the semiconductor body to the light transmissive carrier, wherein the tether or the remnant of the tether is arranged sideways from the semiconductor body and is an additional lateral anchoring structure which enhances the mechanical stability of the connection between the carrier and the semiconductor body.", "10.The semiconductor component according to claim 1, wherein the semiconductor component has a downward emitting configuration and the semiconductor body is arranged on the light transmissive carrier such that its radiation passage area faces the light transmissive carrier and a radiation passage area of the component is formed by a surface of the light transmissive carrier, the surface being remote from the semiconductor body.", "11.A semiconductor component comprising: a light transmissive carrier; a semiconductor body disposed on the light transmissive carrier, the semiconductor body comprising a first semiconductor layer, a second semiconductor layer and an active region being arranged between the first semiconductor layer and the second semiconductor layer, wherein the semiconductor body comprises a first patterned main surface facing the light transmissive carrier and a second main surface facing away from the carrier; a contact structure comprising a first contact area and a second contact area arranged on the second main surface, wherein the second contact area is electrically connected to the second semiconductor layer, and wherein the contact structure comprises a via, the via being electrically connected to the first contact area and extending from the second main surface throughout the second semiconductor layer and the active region into the first semiconductor layer; and an insulating layer covering a vertical surface of the semiconductor body, wherein the insulating layer comprises a structured and mechanically broken tether in regions covering the light transmissive carrier, wherein the semiconductor component is free of a growth substrate, and wherein the light transmissive carrier is an interposer or a final board.", "12.The semiconductor component according to claim 11, wherein the structured and mechanically broken tether is arranged sideways from the semiconductor body and is embedded in a connecting layer fixing the semiconductor body to the light transmissive carrier.", "13.The semiconductor component according to claim 11, wherein, during operation of the semiconductor component, the active region is configured to generate electromagnetic radiation which is coupled out from the semiconductor component at a surface of the light transmissive carrier, the surface being remote from the semiconductor body.", "14.The semiconductor component according to claim 11, wherein the structured and mechanically broken tether is embedded in a connecting layer which mechanically fixes the semiconductor body to the light transmissive carrier, and the structured and mechanically broken tether is arranged sideways from the semiconductor body and is an additional lateral anchoring structure which enhances the mechanical stability of the connection between the carrier and the semiconductor body.", "15.The semiconductor component according to claim 11, wherein the semiconductor component has a downward emitting configuration and the semiconductor body is arranged on the light transmissive carrier such that its radiation passage area faces the light transmissive carrier and a radiation passage area of the component is formed by a surface of the light transmissive carrier, the surface being remote from the semiconductor body.", "16.The semiconductor component according to claim 11, further comprising a first mirror layer and a second mirror layer, wherein the mirror first layer is arranged on a side of the semiconductor body facing the second main surface, wherein the second mirror is embedded into the light transmissive carrier and is arranged sideways from the semiconductor body, and wherein, in a top view, the first mirror layer and the second mirror layer do not overlap.", "17.The semiconductor component according to claim 11, wherein phosphor particles are disposed within the light transmissive carrier.", "18.The semiconductor component according to claim 11, wherein phosphor particles are arranged in a layer disposed on the light transmissive carrier.", "19.A device comprising: a plurality of the semiconductor components according to claim 11, wherein the light transmissive carriers of the semiconductor components are formed as a single common light transmissive carrier." ], [ "<SOH> BACKGROUND <EOH>Area lighting using LEDs necessitates a large number of small LEDs to be die bonded on a carrier.", "This is time-consuming and expensive when using standard methods for producing the LEDs and using standard die bonding techniques." ], [ "<SOH> SUMMARY <EOH>Embodiments of the invention provide a particularly flexible method for producing a semiconductor component or a plurality of semiconductor components.", "Further embodiments provide a semiconductor component which can be produced in a simplified and cost-effective manner.", "According to at least one embodiment of a method for producing a semiconductor component or a plurality of semiconductor components, a substrate is provided.", "The substrate can be patterned or flat.", "For example the substrate is radiation-transmissive, in particular transparent.", "The substrate is, for example, a growth substrate, which may in this case consist inter alia of sapphire or silicon or contain sapphire or silicon.", "According to at least one embodiment of the method for producing the semiconductor component, a semiconductor layer sequence having a first semiconductor layer, a second semiconductor layer and an active region is applied, for instance is grown epitaxially, onto the substrate.", "The semiconductor layer sequence comprises a first main surface facing the substrate and a second main surface facing away from the substrate.", "The first main surface, for example, faces a surface of the substrate.", "The surface of the substrate may be patterned, so that the first main surface is also patterned.", "In particular, the first main surface reproduces a patterned surface of the substrate facing the semiconductor layer sequence.", "The first and second main surfaces in particular delimit the semiconductor layer sequence in a vertical direction.", "A vertical direction is understood to mean a direction which is directed transversely, for instance perpendicularly, to a main extension plane of the active region.", "A lateral direction extends in parallel to the main extension plane of the active region.", "In particular, the lateral direction and the vertical direction are perpendicular to each other.", "For example, the first semiconductor layer is formed as an n-conductive layer and the second semiconductor layer is formed as a p-conductive layer, or vice versa.", "The active region is disposed for instance between the first semiconductor layer and the second semiconductor layer.", "In particular, the active region is a pn-junction zone which is provided for generating or detecting electromagnetic radiation during the operation of the semiconductor component.", "The semiconductor layer sequence is based, for example, on a III-V compound semiconductor material, which comprises at least one element from main group III, such as for example Al, Ga, In, and one element from main group five, such as for example N, P, As.", "In particular, the term “III-V compound semiconductor material” encompasses the group of binary, ternary and quaternary compounds, which contain at least one element from main group III and at least one element from main group five, for example, nitride and phosphide compound semiconductors.", "N-conductive and p-conductive layers may respectively be produced by appropriate doping of the semiconductor material.", "The semiconductor layer sequence may also be based on a II-VI compound semiconductor material.", "According to at least one embodiment of the method, a contact structure comprising at least a first contact area, a second contact area and a via is formed on the side of the second main surface.", "The via is electrically connected for instance to the first contact area.", "For electrically contacting the first semiconductor layer, the via may extend from the second main surface throughout the second semiconductor layer and the active region into the first semiconductor layer.", "It is also possible that the via also extends throughout the first semiconductor layer.", "The second contact area is electrically connected for instance to the second semiconductor layer.", "According to at least one embodiment, the semiconductor layer sequence is structured into a plurality of semiconductor bodies.", "The semiconductor layer sequence may be divided into a plurality of semiconductor bodies, for example, by forming at least one or a plurality of trenches separating the semiconductor bodies in the lateral direction.", "Structuring the semiconductor layer sequence may proceed, for example, by means of an etching and/or a laser separation method, so that at least one mesa trench or a plurality of trenches is formed.", "The trench may extend from the second main surface, remote from the substrate, of the semiconductor layer sequence as far as into the first semiconductor layer or as far as the substrate or as far as into the substrate.", "The trench may be formed such that a bottom surface of the trench is formed by surfaces of the first semiconductor layer and/or of the substrate.", "After structuring the semiconductor layer sequence, the semiconductor bodies are in particular electrically insulated from one another.", "According to at least one embodiment, an insulating layer is applied onto the structured semiconductor layer sequence, wherein the insulating layer covers the trench or the plurality of trenches and vertical surfaces of the semiconductor bodies.", "The insulating layer can be a dielectric layer which contains for instance silicon such as silicon oxide or silicon nitride.", "The insulating layer can be applied to the semiconductor bodies, for example, by sputtering or coating such as chemical or physical vapor deposition.", "According to at least one embodiment, a plurality of tethers is formed by structuring the insulating layer in the region covering the trench.", "In particular, the tethers are formed within the trench or trenches.", "In this case the tethers are arranged laterally from the active regions of the semiconductor bodies in plan view.", "According to at least one embodiment, the substrate is locally detached from the semiconductor bodies.", "Locally detaching the substrate from the semiconductor bodies means that the substrate then is free of a direct physical contact to the semiconductor bodies in particular at least in regions covered by the active regions or the first semiconductor layers of the semiconductor bodies.", "The semiconductor bodies, however, may be still connected to the substrate indirectly, for example, by means of the tethers arranged sideways from the semiconductor bodies.", "The local detachment of the substrate may proceed after the forming of the tethers.", "During and after the step of locally detaching the substrate from the semiconductor bodies, the tethers are in particular attached directly or indirectly to the substrate.", "In this case, the semiconductor bodies may be held in place at least during the step of locally detaching the substrate.", "After the step of locally detaching the substrate from the semiconductor bodies, the substrate is detached from the semiconductor bodies and/or from the semiconductor layer sequence in particular at least in regions which are covered by the active regions of the semiconductor bodies.", "The substrate, however, is preferably attached to the tethers and/or to portions of the first semiconductor layer covered by the tethers.", "In this case, the semiconductor bodies are connected to the substrate preferably only indirectly by means of the tethers.", "Detaching the substrate from the semiconductor bodies may proceed, for example, by means of an etching method or of a laser lift-off method.", "Using a laser lift-off method, radiation is introduced, for example, throughout the substrate, so that a separation zone may be decomposed and the semiconductor bodies can be detached from the substrate.", "According to at least one embodiment, at least one semiconductor body having one first semiconductor layer, one second semiconductor layer and one active region together with one associated contact structure is selectively picked out by separating the tethers from the substrate.", "Separating the tethers from the substrate may be performed by mechanically breaking the tethers or by releasing or dissolving the tethers from the substrate.", "The at least one semiconductor body may be then separated completely from the substrate and transferred to a carrier, such as an interposer or a final board.", "The semiconductor body, which is mechanically connected to the substrate in particular only by means of the tethers, may be selectively removed by a stamp attached to the semiconductor body on the side of its second main surface.", "By lifting away the semiconductor body from the substrate, the tethers attaching the semiconductor body to the substrate can be mechanically broken or released, so that the semiconductor body is separated completely from the substrate.", "It is also possible that a plurality of the semiconductor bodies is selectively removed simultaneously or one after another from the substrate.", "In accordance with at least one embodiment of a method for producing a plurality of semiconductor components each having a semiconductor body, a semiconductor layer sequence is applied on a substrate, wherein the semiconductor layer sequence comprises a first semiconductor layer, a second semiconductor layer and an active region being disposed between the first and the second semiconductor layers.", "A contact structure is formed for electrically contacting the first semiconductor layer and the second semiconductor layer.", "For electrically contacting the first semiconductor layer, by way of example, the contact structure comprises at least one via or a plurality of vias extending throughout the second semiconductor layer and the active region.", "The semiconductor layer sequence is structured into a plurality of semiconductor bodies by forming at least one trench or a plurality of trenches separating the semiconductor bodies.", "An insulating layer is applied onto the semiconductor layer sequence to cover the trench or the plurality of trenches and vertical surfaces of the semiconductor bodies.", "In a next step, a plurality of tethers is formed by structuring the insulating layer in regions covering the trench or the plurality of trenches.", "After forming the tethers, the substrate is locally detached from the semiconductor bodies, while the tethers remain attached to the substrate.", "Each individual semiconductor body or a plurality of the semiconductor bodies may then be selectively picked up from the substrate by separating the tethers from the substrate, wherein the semiconductor body comprises one first semiconductor layer, one second semiconductor layer and one active region together with one associated contact structure.", "Using the tethers' binding to the growth substrate, wherein the tethers connected to the semiconductor bodies are formed after forming a plurality of trenches separating or isolating the semiconductor bodies from each other, each individual semiconductor body may be held in place by the tethers during the step of locally detaching the substrate from the semiconductor bodies.", "In a subsequent step, the semiconductor bodies may be selectively picked up, for example, by a stamp, by breaking or releasing the tethers from the substrate.", "The semiconductor bodies can be transferred one after the other or in a large number simultaneously to a carrier, such as an interposer or a final board.", "According to at least one embodiment, the semiconductor body or a plurality of semiconductor bodies are printed in a downward emitting configuration on a transparent carrier.", "A downward emitting configuration means that the semiconductor body is arranged on the carrier in such a way that its radiation passage area faces the carrier.", "For example, the semiconductor body is applied onto a connecting layer disposed on the carrier.", "The connecting layer may be an adhesive layer and/or an epoxy layer which, for example, is cured after printing the semiconductor body.", "The tethers or remnants of the broken tethers may serve as lateral anchoring structures additionally enhancing the mechanical stability of the connection between a semiconductor body and the carrier.", "According to at least one embodiment, the insulating layer is structured so that the tethers associated with different semiconductor bodies are disconnected.", "It is also possible that at least an anchor bar is formed between the semiconductor bodies by structuring the insulating layer in the region covering the trench or the plurality of trenches, wherein the semiconductor bodies are connected to the anchor bar by the tethers.", "The anchor bar, for example, extends along at least one trench separating the semiconductor bodies.", "The anchor bar additionally contributes to hold the semiconductor bodies in place during the step of separating the substrate from the semiconductor bodies.", "According to at least one embodiment, at least one trench is formed throughout the second semiconductor layer as well as the active region into the first semiconductor layer of the semiconductor layer sequence, so that a bottom surface of the trench is formed at least partially by a surface of the first semiconductor layer.", "Within the trench, the insulating layer may be formed to cover the first semiconductor layer.", "In this case, the tethers may be formed by structuring the insulating layer and in particular also the first semiconductor layer, such that in plan view, the tethers cover the first semiconductor layer within the trench or trenches.", "It is also possible that the insulating layer within the trench or trenches is structured into a plurality of tethers and anchor bars, wherein the anchor bars may cover also the first semiconductor layer within the trench or trenches.", "In this way, the first semiconductor layer within the trench or trenches increases the mechanical strength of the tethers and anchor bars.", "According to at least one embodiment, at least one trench or a plurality of trenches is formed throughout the semiconductor layer sequence, such that a surface, in particular a patterned surface, of the substrate is partially exposed within the trench or trenches.", "By applying the insulating layer covering the trench or the plurality of trenches, the insulating layer may penetrate into the patterned substrate such that the insulating layer and the tethers to be formed are anchored to the substrate.", "An interface between the substrate and the insulating layer is enlarged due to the patterned surface of the substrate, so that an adhesion area for the tethers and/or for the anchor bars on the patterned surface is increased.", "According to at least one embodiment, the substrate is locally detached from the semiconductor bodies by a laser lift-off process.", "The substrate, for example, is formed by a material which is radiation-transmissive, in particular transparent for a radiation used by the laser lift-off process.", "The substrate, for example, contains gallium nitride or silicon carbide or sapphire.", "The radiation may be targeted specifically onto the semiconductor bodies.", "Furthermore, due to different absorption coefficients of the material the semiconductor bodies and of the material of the tethers and/or of the anchor bars, the semiconductor bodies may be separated from the substrate while leaving the tethers and/or the anchor bars remaining attached to the substrate.", "Hence, using a laser lift-off process, the semiconductor bodies can be selectively locally detached from the substrate in a simplified way.", "According to at least one embodiment, the substrate is locally detached from the semiconductor bodies by means of an etching method.", "The semiconductor bodies may be under-etched by a wet etchant.", "In particular, a directional etching method is used for separating the substrate from the semiconductor bodies.", "The tethers and the anchor bars may be designed to take advantage of the directional etching.", "The anchor bars can be formed in such a way that the substrate is etched only in a lateral direction being parallel to the anchor bars and is not etched along a lateral direction which is perpendicular to the anchor bars.", "The substrate in this case may be formed of silicon.", "For the directional etching, wet etchants such as KOH may be used.", "In this way, the substrate may be locally detached from the semiconductor bodies, while the tethers remain attached to the substrate.", "According to at least one embodiment, a combination of etching methods is used to locally detach the substrate form the semiconductor bodies and to pattern the first main surfaces of the semiconductor bodies facing the substrate.", "In this case, the semiconductor layer sequence may be grown onto an unpatterned, for example, a flat or a plane surface of the substrate, so that the first main surface of the semiconductor layer sequence may be unpatterned at first.", "After structuring the semiconductor layer sequence into a plurality of semiconductor bodies, the first main surfaces of the semiconductor bodies facing the substrate may be patterned for example by means of an etching method.", "In particular, the patterning proceeds after the step of forming the plurality of tethers and prior to the step of picking up the semiconductor bodies from the substrate by separating the tethers.", "The patterning of the first main surfaces of the semiconductor bodies may be performed during the step of locally detaching the substrate from the semiconductor bodies or after the step of locally detaching the substrate and prior to the step of separating the tethers.", "It is possible that a single etchant is used for locally detaching the substrate from the semiconductor bodies and for the patterning of the main surfaces of the semiconductor bodies.", "For example, the etchant KOH may be used to detach the substrate containing silicon for instance and simultaneously may be used to pattern the first semiconductor layer containing gallium nitride for instance.", "It is also possible that a combination of two etching processes are used in sequence, namely for locally detaching the substrate at first and then for patterning the first main surfaces of the semiconductor bodies while being connected to the substrate by means of the tethers.", "In accordance with at least one embodiment, the semiconductor component has a contact structure and a semiconductor body arranged on a light transmissive carrier, wherein the semiconductor body comprises a first semiconductor layer, a second semiconductor layer and an active region being arranged between the first semiconductor layer and the second semiconductor layer.", "The semiconductor body comprises a first patterned main surface facing the carrier and a second main surface facing away from the carrier.", "The contact structure comprises a first contact area and a second contact area arranged on the side of the second main surface, wherein the second contact area is electrically connected to the second semiconductor layer.", "The contact structure comprises a via being electrically connected to the first contact area and extends in vertical direction in particular from the second main surface throughout the second semiconductor layer and the active region into the first semiconductor layer.", "At least a vertical surface of the semiconductor body is covered by an insulating layer which comprises a tether or a remnant of the tether.", "Moreover, the semiconductor component is in particular free of a growth substrate.", "Such a semiconductor component can be produced by the methods for producing a semiconductor component described herein.", "Therefore, features described in connection with the methods for producing a semiconductor component or a plurality of semiconductor components can also be used for the semiconductor component, and vice versa.", "According to at least one embodiment, the component comprises a connecting layer which mechanically fixes the semiconductor body to the light transmissive carrier.", "The component comprises in particular at least one or a plurality of tethers or remnants of the tethers being arranged laterally from the semiconductor body and embedded in the connecting layer.", "The tether or remnant of the tether is in particular part of an insulating layer covering an vertical surface of the semiconductor body.", "According to at least one embodiment, the component comprises a mirror layer which is arranged on the side of the second main surface of the semiconductor body.", "Furthermore, the semiconductor component may comprise a further mirror layer which, for example, is embedded into the light transmissive carrier.", "In particular, the further mirror is arranged sideway from the semiconductor body.", "In a plane view, the mirror layer and the further mirror layer are in particular free of overlaps.", "The light transmissive carrier may comprise a plurality of such further mirror layers.", "According to a preferred embodiment, the active region is configured to generate electromagnetic radiation during operation of the semiconductor component.", "The electromagnetic radiation may be coupled out from the semiconductor component at a surface of the light transmissive carrier.", "The efficiency of light out-coupling may be negatively affected by effects of total internal reflection at the surface of the light transmissive carrier.", "Electromagnetic radiation reflected back into the carrier, however, may be reflected by the further mirror layer back to a forward direction resulting in an increase of the efficiency of light out-coupling.", "According to at least one embodiment, phosphor particles and/or scattering particles are disposed between the semiconductor body and a radiation passage area of the semiconductor component.", "The radiation passage area of the component may be formed by the surface of the light transmissive carrier, the surface being remote from the semiconductor body.", "Phosphor particles may absorb electromagnetic radiation emitted by the active region and re-emit an electromagnetic radiation having a longer peak wavelength in comparison with the electromagnetic radiation absorbed by the phosphor particles, so that the component may emit white light in total.", "The phosphor particles and/or the scattering particles may be disposed within the light transmissive carrier.", "Alternatively, the phosphor particles and/or the scattering particles may be embedded in a layer which is disposed between the carrier and the semiconductor body or on the side of the surface of the carrier being remote from the semiconductor body.", "A plurality of the semiconductor bodies may be arranged on a single common light transmissive carrier, so that a device having a plurality of semiconductor components and a common light transmissive carrier is formed.", "The semiconductor bodies may be arranged in the form of a matrix having columns and rows on the single common light transmissive carrier.", "The common light transmissive carrier may comprise a plurality of further mirror layers, wherein the further mirror layers in each case may be arranged between two neighbouring columns or rows of the semiconductor bodies." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This is a divisional application of U.S. patent application Ser.", "No.", "15/009,744 filed Jan. 28, 2016 and issued as U.S. Pat.", "No.", "9,887,180 on Feb. 6, 2018, which claims the benefit of U.S.", "Provisional Application No.", "62/110,358, filed on Jan. 30, 2015, both of which are incorporated herein by reference.", "TECHNICAL FIELD The invention relates to a method for producing a semiconductor component and to a semiconductor component.", "BACKGROUND Area lighting using LEDs necessitates a large number of small LEDs to be die bonded on a carrier.", "This is time-consuming and expensive when using standard methods for producing the LEDs and using standard die bonding techniques.", "SUMMARY Embodiments of the invention provide a particularly flexible method for producing a semiconductor component or a plurality of semiconductor components.", "Further embodiments provide a semiconductor component which can be produced in a simplified and cost-effective manner.", "According to at least one embodiment of a method for producing a semiconductor component or a plurality of semiconductor components, a substrate is provided.", "The substrate can be patterned or flat.", "For example the substrate is radiation-transmissive, in particular transparent.", "The substrate is, for example, a growth substrate, which may in this case consist inter alia of sapphire or silicon or contain sapphire or silicon.", "According to at least one embodiment of the method for producing the semiconductor component, a semiconductor layer sequence having a first semiconductor layer, a second semiconductor layer and an active region is applied, for instance is grown epitaxially, onto the substrate.", "The semiconductor layer sequence comprises a first main surface facing the substrate and a second main surface facing away from the substrate.", "The first main surface, for example, faces a surface of the substrate.", "The surface of the substrate may be patterned, so that the first main surface is also patterned.", "In particular, the first main surface reproduces a patterned surface of the substrate facing the semiconductor layer sequence.", "The first and second main surfaces in particular delimit the semiconductor layer sequence in a vertical direction.", "A vertical direction is understood to mean a direction which is directed transversely, for instance perpendicularly, to a main extension plane of the active region.", "A lateral direction extends in parallel to the main extension plane of the active region.", "In particular, the lateral direction and the vertical direction are perpendicular to each other.", "For example, the first semiconductor layer is formed as an n-conductive layer and the second semiconductor layer is formed as a p-conductive layer, or vice versa.", "The active region is disposed for instance between the first semiconductor layer and the second semiconductor layer.", "In particular, the active region is a pn-junction zone which is provided for generating or detecting electromagnetic radiation during the operation of the semiconductor component.", "The semiconductor layer sequence is based, for example, on a III-V compound semiconductor material, which comprises at least one element from main group III, such as for example Al, Ga, In, and one element from main group five, such as for example N, P, As.", "In particular, the term “III-V compound semiconductor material” encompasses the group of binary, ternary and quaternary compounds, which contain at least one element from main group III and at least one element from main group five, for example, nitride and phosphide compound semiconductors.", "N-conductive and p-conductive layers may respectively be produced by appropriate doping of the semiconductor material.", "The semiconductor layer sequence may also be based on a II-VI compound semiconductor material.", "According to at least one embodiment of the method, a contact structure comprising at least a first contact area, a second contact area and a via is formed on the side of the second main surface.", "The via is electrically connected for instance to the first contact area.", "For electrically contacting the first semiconductor layer, the via may extend from the second main surface throughout the second semiconductor layer and the active region into the first semiconductor layer.", "It is also possible that the via also extends throughout the first semiconductor layer.", "The second contact area is electrically connected for instance to the second semiconductor layer.", "According to at least one embodiment, the semiconductor layer sequence is structured into a plurality of semiconductor bodies.", "The semiconductor layer sequence may be divided into a plurality of semiconductor bodies, for example, by forming at least one or a plurality of trenches separating the semiconductor bodies in the lateral direction.", "Structuring the semiconductor layer sequence may proceed, for example, by means of an etching and/or a laser separation method, so that at least one mesa trench or a plurality of trenches is formed.", "The trench may extend from the second main surface, remote from the substrate, of the semiconductor layer sequence as far as into the first semiconductor layer or as far as the substrate or as far as into the substrate.", "The trench may be formed such that a bottom surface of the trench is formed by surfaces of the first semiconductor layer and/or of the substrate.", "After structuring the semiconductor layer sequence, the semiconductor bodies are in particular electrically insulated from one another.", "According to at least one embodiment, an insulating layer is applied onto the structured semiconductor layer sequence, wherein the insulating layer covers the trench or the plurality of trenches and vertical surfaces of the semiconductor bodies.", "The insulating layer can be a dielectric layer which contains for instance silicon such as silicon oxide or silicon nitride.", "The insulating layer can be applied to the semiconductor bodies, for example, by sputtering or coating such as chemical or physical vapor deposition.", "According to at least one embodiment, a plurality of tethers is formed by structuring the insulating layer in the region covering the trench.", "In particular, the tethers are formed within the trench or trenches.", "In this case the tethers are arranged laterally from the active regions of the semiconductor bodies in plan view.", "According to at least one embodiment, the substrate is locally detached from the semiconductor bodies.", "Locally detaching the substrate from the semiconductor bodies means that the substrate then is free of a direct physical contact to the semiconductor bodies in particular at least in regions covered by the active regions or the first semiconductor layers of the semiconductor bodies.", "The semiconductor bodies, however, may be still connected to the substrate indirectly, for example, by means of the tethers arranged sideways from the semiconductor bodies.", "The local detachment of the substrate may proceed after the forming of the tethers.", "During and after the step of locally detaching the substrate from the semiconductor bodies, the tethers are in particular attached directly or indirectly to the substrate.", "In this case, the semiconductor bodies may be held in place at least during the step of locally detaching the substrate.", "After the step of locally detaching the substrate from the semiconductor bodies, the substrate is detached from the semiconductor bodies and/or from the semiconductor layer sequence in particular at least in regions which are covered by the active regions of the semiconductor bodies.", "The substrate, however, is preferably attached to the tethers and/or to portions of the first semiconductor layer covered by the tethers.", "In this case, the semiconductor bodies are connected to the substrate preferably only indirectly by means of the tethers.", "Detaching the substrate from the semiconductor bodies may proceed, for example, by means of an etching method or of a laser lift-off method.", "Using a laser lift-off method, radiation is introduced, for example, throughout the substrate, so that a separation zone may be decomposed and the semiconductor bodies can be detached from the substrate.", "According to at least one embodiment, at least one semiconductor body having one first semiconductor layer, one second semiconductor layer and one active region together with one associated contact structure is selectively picked out by separating the tethers from the substrate.", "Separating the tethers from the substrate may be performed by mechanically breaking the tethers or by releasing or dissolving the tethers from the substrate.", "The at least one semiconductor body may be then separated completely from the substrate and transferred to a carrier, such as an interposer or a final board.", "The semiconductor body, which is mechanically connected to the substrate in particular only by means of the tethers, may be selectively removed by a stamp attached to the semiconductor body on the side of its second main surface.", "By lifting away the semiconductor body from the substrate, the tethers attaching the semiconductor body to the substrate can be mechanically broken or released, so that the semiconductor body is separated completely from the substrate.", "It is also possible that a plurality of the semiconductor bodies is selectively removed simultaneously or one after another from the substrate.", "In accordance with at least one embodiment of a method for producing a plurality of semiconductor components each having a semiconductor body, a semiconductor layer sequence is applied on a substrate, wherein the semiconductor layer sequence comprises a first semiconductor layer, a second semiconductor layer and an active region being disposed between the first and the second semiconductor layers.", "A contact structure is formed for electrically contacting the first semiconductor layer and the second semiconductor layer.", "For electrically contacting the first semiconductor layer, by way of example, the contact structure comprises at least one via or a plurality of vias extending throughout the second semiconductor layer and the active region.", "The semiconductor layer sequence is structured into a plurality of semiconductor bodies by forming at least one trench or a plurality of trenches separating the semiconductor bodies.", "An insulating layer is applied onto the semiconductor layer sequence to cover the trench or the plurality of trenches and vertical surfaces of the semiconductor bodies.", "In a next step, a plurality of tethers is formed by structuring the insulating layer in regions covering the trench or the plurality of trenches.", "After forming the tethers, the substrate is locally detached from the semiconductor bodies, while the tethers remain attached to the substrate.", "Each individual semiconductor body or a plurality of the semiconductor bodies may then be selectively picked up from the substrate by separating the tethers from the substrate, wherein the semiconductor body comprises one first semiconductor layer, one second semiconductor layer and one active region together with one associated contact structure.", "Using the tethers' binding to the growth substrate, wherein the tethers connected to the semiconductor bodies are formed after forming a plurality of trenches separating or isolating the semiconductor bodies from each other, each individual semiconductor body may be held in place by the tethers during the step of locally detaching the substrate from the semiconductor bodies.", "In a subsequent step, the semiconductor bodies may be selectively picked up, for example, by a stamp, by breaking or releasing the tethers from the substrate.", "The semiconductor bodies can be transferred one after the other or in a large number simultaneously to a carrier, such as an interposer or a final board.", "According to at least one embodiment, the semiconductor body or a plurality of semiconductor bodies are printed in a downward emitting configuration on a transparent carrier.", "A downward emitting configuration means that the semiconductor body is arranged on the carrier in such a way that its radiation passage area faces the carrier.", "For example, the semiconductor body is applied onto a connecting layer disposed on the carrier.", "The connecting layer may be an adhesive layer and/or an epoxy layer which, for example, is cured after printing the semiconductor body.", "The tethers or remnants of the broken tethers may serve as lateral anchoring structures additionally enhancing the mechanical stability of the connection between a semiconductor body and the carrier.", "According to at least one embodiment, the insulating layer is structured so that the tethers associated with different semiconductor bodies are disconnected.", "It is also possible that at least an anchor bar is formed between the semiconductor bodies by structuring the insulating layer in the region covering the trench or the plurality of trenches, wherein the semiconductor bodies are connected to the anchor bar by the tethers.", "The anchor bar, for example, extends along at least one trench separating the semiconductor bodies.", "The anchor bar additionally contributes to hold the semiconductor bodies in place during the step of separating the substrate from the semiconductor bodies.", "According to at least one embodiment, at least one trench is formed throughout the second semiconductor layer as well as the active region into the first semiconductor layer of the semiconductor layer sequence, so that a bottom surface of the trench is formed at least partially by a surface of the first semiconductor layer.", "Within the trench, the insulating layer may be formed to cover the first semiconductor layer.", "In this case, the tethers may be formed by structuring the insulating layer and in particular also the first semiconductor layer, such that in plan view, the tethers cover the first semiconductor layer within the trench or trenches.", "It is also possible that the insulating layer within the trench or trenches is structured into a plurality of tethers and anchor bars, wherein the anchor bars may cover also the first semiconductor layer within the trench or trenches.", "In this way, the first semiconductor layer within the trench or trenches increases the mechanical strength of the tethers and anchor bars.", "According to at least one embodiment, at least one trench or a plurality of trenches is formed throughout the semiconductor layer sequence, such that a surface, in particular a patterned surface, of the substrate is partially exposed within the trench or trenches.", "By applying the insulating layer covering the trench or the plurality of trenches, the insulating layer may penetrate into the patterned substrate such that the insulating layer and the tethers to be formed are anchored to the substrate.", "An interface between the substrate and the insulating layer is enlarged due to the patterned surface of the substrate, so that an adhesion area for the tethers and/or for the anchor bars on the patterned surface is increased.", "According to at least one embodiment, the substrate is locally detached from the semiconductor bodies by a laser lift-off process.", "The substrate, for example, is formed by a material which is radiation-transmissive, in particular transparent for a radiation used by the laser lift-off process.", "The substrate, for example, contains gallium nitride or silicon carbide or sapphire.", "The radiation may be targeted specifically onto the semiconductor bodies.", "Furthermore, due to different absorption coefficients of the material the semiconductor bodies and of the material of the tethers and/or of the anchor bars, the semiconductor bodies may be separated from the substrate while leaving the tethers and/or the anchor bars remaining attached to the substrate.", "Hence, using a laser lift-off process, the semiconductor bodies can be selectively locally detached from the substrate in a simplified way.", "According to at least one embodiment, the substrate is locally detached from the semiconductor bodies by means of an etching method.", "The semiconductor bodies may be under-etched by a wet etchant.", "In particular, a directional etching method is used for separating the substrate from the semiconductor bodies.", "The tethers and the anchor bars may be designed to take advantage of the directional etching.", "The anchor bars can be formed in such a way that the substrate is etched only in a lateral direction being parallel to the anchor bars and is not etched along a lateral direction which is perpendicular to the anchor bars.", "The substrate in this case may be formed of silicon.", "For the directional etching, wet etchants such as KOH may be used.", "In this way, the substrate may be locally detached from the semiconductor bodies, while the tethers remain attached to the substrate.", "According to at least one embodiment, a combination of etching methods is used to locally detach the substrate form the semiconductor bodies and to pattern the first main surfaces of the semiconductor bodies facing the substrate.", "In this case, the semiconductor layer sequence may be grown onto an unpatterned, for example, a flat or a plane surface of the substrate, so that the first main surface of the semiconductor layer sequence may be unpatterned at first.", "After structuring the semiconductor layer sequence into a plurality of semiconductor bodies, the first main surfaces of the semiconductor bodies facing the substrate may be patterned for example by means of an etching method.", "In particular, the patterning proceeds after the step of forming the plurality of tethers and prior to the step of picking up the semiconductor bodies from the substrate by separating the tethers.", "The patterning of the first main surfaces of the semiconductor bodies may be performed during the step of locally detaching the substrate from the semiconductor bodies or after the step of locally detaching the substrate and prior to the step of separating the tethers.", "It is possible that a single etchant is used for locally detaching the substrate from the semiconductor bodies and for the patterning of the main surfaces of the semiconductor bodies.", "For example, the etchant KOH may be used to detach the substrate containing silicon for instance and simultaneously may be used to pattern the first semiconductor layer containing gallium nitride for instance.", "It is also possible that a combination of two etching processes are used in sequence, namely for locally detaching the substrate at first and then for patterning the first main surfaces of the semiconductor bodies while being connected to the substrate by means of the tethers.", "In accordance with at least one embodiment, the semiconductor component has a contact structure and a semiconductor body arranged on a light transmissive carrier, wherein the semiconductor body comprises a first semiconductor layer, a second semiconductor layer and an active region being arranged between the first semiconductor layer and the second semiconductor layer.", "The semiconductor body comprises a first patterned main surface facing the carrier and a second main surface facing away from the carrier.", "The contact structure comprises a first contact area and a second contact area arranged on the side of the second main surface, wherein the second contact area is electrically connected to the second semiconductor layer.", "The contact structure comprises a via being electrically connected to the first contact area and extends in vertical direction in particular from the second main surface throughout the second semiconductor layer and the active region into the first semiconductor layer.", "At least a vertical surface of the semiconductor body is covered by an insulating layer which comprises a tether or a remnant of the tether.", "Moreover, the semiconductor component is in particular free of a growth substrate.", "Such a semiconductor component can be produced by the methods for producing a semiconductor component described herein.", "Therefore, features described in connection with the methods for producing a semiconductor component or a plurality of semiconductor components can also be used for the semiconductor component, and vice versa.", "According to at least one embodiment, the component comprises a connecting layer which mechanically fixes the semiconductor body to the light transmissive carrier.", "The component comprises in particular at least one or a plurality of tethers or remnants of the tethers being arranged laterally from the semiconductor body and embedded in the connecting layer.", "The tether or remnant of the tether is in particular part of an insulating layer covering an vertical surface of the semiconductor body.", "According to at least one embodiment, the component comprises a mirror layer which is arranged on the side of the second main surface of the semiconductor body.", "Furthermore, the semiconductor component may comprise a further mirror layer which, for example, is embedded into the light transmissive carrier.", "In particular, the further mirror is arranged sideway from the semiconductor body.", "In a plane view, the mirror layer and the further mirror layer are in particular free of overlaps.", "The light transmissive carrier may comprise a plurality of such further mirror layers.", "According to a preferred embodiment, the active region is configured to generate electromagnetic radiation during operation of the semiconductor component.", "The electromagnetic radiation may be coupled out from the semiconductor component at a surface of the light transmissive carrier.", "The efficiency of light out-coupling may be negatively affected by effects of total internal reflection at the surface of the light transmissive carrier.", "Electromagnetic radiation reflected back into the carrier, however, may be reflected by the further mirror layer back to a forward direction resulting in an increase of the efficiency of light out-coupling.", "According to at least one embodiment, phosphor particles and/or scattering particles are disposed between the semiconductor body and a radiation passage area of the semiconductor component.", "The radiation passage area of the component may be formed by the surface of the light transmissive carrier, the surface being remote from the semiconductor body.", "Phosphor particles may absorb electromagnetic radiation emitted by the active region and re-emit an electromagnetic radiation having a longer peak wavelength in comparison with the electromagnetic radiation absorbed by the phosphor particles, so that the component may emit white light in total.", "The phosphor particles and/or the scattering particles may be disposed within the light transmissive carrier.", "Alternatively, the phosphor particles and/or the scattering particles may be embedded in a layer which is disposed between the carrier and the semiconductor body or on the side of the surface of the carrier being remote from the semiconductor body.", "A plurality of the semiconductor bodies may be arranged on a single common light transmissive carrier, so that a device having a plurality of semiconductor components and a common light transmissive carrier is formed.", "The semiconductor bodies may be arranged in the form of a matrix having columns and rows on the single common light transmissive carrier.", "The common light transmissive carrier may comprise a plurality of further mirror layers, wherein the further mirror layers in each case may be arranged between two neighbouring columns or rows of the semiconductor bodies.", "BRIEF DESCRIPTION OF THE DRAWINGS For a more complete understanding of embodiments of the present invention, and the advantages thereof, reference is now made to the following descriptions taken in conjunction with the accompanying drawings, in which: FIG.", "1 shows a schematic sectional view of a substrate with a mirror layer and a connection layer according to an embodiment, FIG.", "2 shows a schematic sectional view of the substrate with a dielectric layer according to an embodiment, FIG.", "3 shows a schematic sectional view of the substrate with a passivation layer and a plurality of recesses according to an embodiment, FIG.", "4 shows a schematic sectional view of the substrate with a plurality of openings in the passivation layer and the dielectric layer and a trench forming semiconductor bodies according to an embodiment, FIG.", "5 shows a schematic sectional view of the substrate with a plurality of contact areas formed in the openings and the recesses according to an embodiment, FIG.", "6A shows a schematic sectional view of the substrate with an insulating layer disposed on the semiconductor bodies according to an embodiment, FIG.", "6B shows a top view of a contact structure according to an embodiment, FIG.", "6C shows a top view of a contact structure according to an embodiment, FIG.", "7A shows a schematic sectional view of the substrate being separated from the semiconductor bodies according to an embodiment, FIG.", "7B shows a schematic sectional view of the substrate being separated from the semiconductor bodies according to an embodiment, FIG.", "7C shows a top view of a contact structure after separating the substrate from the semiconductor bodies according to an embodiment, FIG.", "8A shows a schematic sectional view of lifting off a semiconductor body from the substrate according to an embodiment, FIG.", "8B shows a schematic sectional view of lifting off a semiconductor body from the substrate according to an embodiment, FIG.", "9A shows a first exemplified embodiment of a semiconductor component, FIG.", "9B shows a second exemplified embodiment of a semiconductor component, FIG.", "10 shows a third exemplified embodiment of a semiconductor component, FIG.", "11 shows an exemplified embodiment of a semiconductor component with phosphor and/or scattering particles embedded in the carrier, FIG.", "12 shows an exemplified embodiment of a device comprising a plurality of semiconductor components, and FIG.", "13A shows a schematic sectional view illustrating a production step corresponding to FIG.", "1 but with a substrate having a flat surface, FIG.", "13B shows a schematic sectional view illustrating a production step corresponding to FIG.", "6A but with a substrate having a flat surface, FIG.", "13C shows a schematic sectional view illustrating a production step corresponding to FIG.", "13B but with a different insulating layer, FIG.", "13D shows a schematic sectional view illustrating a production step corresponding to FIG.", "13B but with a different trench, FIG.", "13E shows a schematic sectional view illustrating a production step corresponding to FIG.", "7B but with a sequence layer grown on a substrate having a flat surface.", "Identical or similar elements, or elements acting in an identical manner, are provided with the same reference numerals in the figures.", "In each case, the figures are schematic views and are therefore not necessarily true to scale.", "Rather, comparatively small elements, and in particular layer thicknesses, may be illustrated excessively large for clarification purposes.", "DETAILED DESCRIPTION OF ILLUSTRATIVE EMBODIMENTS In FIG.", "1, a substrate 9 is provided.", "The substrate 9 has a surface 91 which is patterned.", "It is also possible that the surface 91 of the substrate 9 is not patterned and is formed as a flat surface.", "The substrate 9 is, for example, radiation-transmissive, in particular transparent for electromagnetic radiation in visible, infrared and/or ultraviolet spectral ranges.", "The substrate 9 may comprise gallium nitride or silicon carbide or sapphire.", "Alternatively, the substrate 9 can be radiation-opaque.", "In this case, the substrate 9 may be a silicon substrate.", "A semiconductor layer sequence 200 is applied onto the surface 91 of the substrate 9.The semiconductor layer sequence 200 comprises a first semiconductor layer 21, a second semiconductor layer 22 and an active region 23 which is disposed between the first semiconductor layer 21 and the second semiconductor layer 22.The first semiconductor layer 21 may be an n-conductive layer and the second semiconductor layer 22 may be a p-conductive layer, or vice versa.", "The active region 23, for example, is configured for generating electromagnetic radiation or for absorbing and transforming electromagnetic radiation into electrical signals or energy.", "The semiconductor layer sequence 200 may be grown epitaxially on the substrate 9.The semiconductor layer sequence 200 has a first main surface 201 facing the substrate 9 and a second main surface 202 which is remote from the substrate 9.The first main surface 201 is patterned which may be formed by a surface of the first semiconductor layer 21 facing substrate 9.A patterned substrate 9 may improve the quality of the epitaxial semiconductor layers of the semiconductor layer sequence 200.Moreover, the semiconductor layer sequence 200 may be grown onto the patterned surface 91 of the substrate 9, such that the first patterned main surface 201 reproduces the patterned surface 91 of the substrate 9.A mirror layer 3 is deposited onto the second main surface 202 remote from the substrate 9.The mirror layer 3 comprises a plurality of sub-regions being laterally separated from one another.", "In particular, the mirror layer 3 comprises a plurality of openings 30.Each of the sub-regions of the mirror layer 3 may be continuous and comprises, for instance, at least one of the openings 30 of the mirror layer 3.The mirror layer 3 is in particular electrically conductive.", "In top view, the mirror layer 3 is covered by a connection layer 4 which is, for example, also electrically conductive.", "The mirror layer 3 and/or the connection layer 4 may contain a metal such as aluminium, rhodium, palladium, silver, gold or platinum or alloys of these elements.", "In FIG.", "2, a dielectric layer 5, for example, a silicon nitride layer or a silicon oxide layer, is applied on the semiconductor layer sequence 200, wherein the dielectric layer 5 covers the connection layer 4 and in particular the semiconductor layer sequence 200 completely.", "In FIG.", "3, a plurality of recesses 24 are formed in regions of the openings 30 of the mirror layer 3.In vertical direction, each recess 24 extends throughout the dielectric layer 5, the second semiconductor layer 22, the active region 23 into the first semiconductor layer 21.The recess 24 forms a blind hole in the semiconductor layer sequence 200, wherein in lateral direction the recess 24 is surrounded by the semiconductor layer sequence 200 for instance completely.", "The recesses 24 may be formed by an etching method, for example, by a dry etching method.", "After forming the recesses 24, a passivation layer 61, for example, a silicon oxide layer such as SiO2 or a silicon nitride layer, is formed to cover vertical surfaces of the recesses 24.It is possible that the passivation layer 61 covers the recesses 24 and the dielectric layer 5 completely.", "In a subsequent step, the passivation layer 61 may be partially removed.", "The passivation layer 61 and the dielectric layer 5 preferably comprise different dielectric materials.", "By way of example, the dielectric layer 5 contains or mainly consists of silicon nitride and the passivation layer 61 contains or mainly consists of silicon oxide.", "In FIG.", "4 the passivation layer 61 is partially removed, for example, by etching, such that the first semiconductor layer 21 is exposed in the regions of the recesses 24.By partially removing the passivation layer 61, the dielectric layer 5 is also at least partially exposed.", "In a next step, the dielectric layer 5 is removed, for example, by etching, in places such that the dielectric layer 5 comprises in addition to first openings 51 in the regions of the recesses 24, a plurality of second openings 52 arranged laterally to the recesses 24.In the second openings 52, an electrically conductive layer such as the connection layer 4 is partially exposed.", "In FIG.", "5, a contact structure 7 comprising a first contact area 71, a second contact area 72 and a via 70 is formed on the side of the second main surface 202 of the semiconductor layer sequence 200.The first contact area 71 and the second contact area 72 are laterally separated and in this way electrically isolated from each other.", "In vertical direction, the second contact area 72 extends through the second opening 52 of the dielectric layer 5 and is electrically connected to the second semiconductor layer 22 by means of the mirror layer 3 and the connection layer 4.The first contact area 71 is deposited outside the recess 24 and is electrically connected to the via 70, wherein the via 70 is arranged inside the recess 24.In vertical direction, the via 70 extends at least from the second main surface 202 throughout the second semiconductor layer 22 and the active region 23 into the first semiconductor layer 21.In particular for testing purposes, the semiconductor layer sequence 200 may be electrically connected to an external current source by means of the first and second contact area 71 and 72 arranged on the second main surface 202 remote from the substrate 9.Within the recess 24, in lateral direction, the via 70 is electrically isolated from the second semiconductor layer 22 and the active region 23 by means of the passivation layer 61 covering vertical surfaces of the recess 24.In FIG.", "5, the semiconductor layer sequence 200 is structured laterally into a plurality of semiconductor bodies 2.Lateral structuring means that the semiconductor layer sequence 200 is divided into a plurality of semiconductor bodies 2 being spaced laterally apart from one another.", "A mesa trench 20 or a plurality of trenches 20 are formed between the semiconductor bodies 2.In vertical direction, the trench 20 extends throughout the semiconductor layer sequence 200 as far as to the substrate, so that the surface 91, in particular the patterned surface 91, of the substrate 9 is partially exposed within the trench 20 or trenches 20.A bottom surface of the trench 20 may be formed by the patterned surface 91 of the substrate 9.The trenches 20 may be formed by an etching method, for instance by a dry, wet or laser etching method, in particular in regions between the sub-regions of the mirror layer 3.The trench 20 may also be formed sideways from the semiconductor layer sequence 200.In FIG.", "6A, an insulating layer 6 is applied onto the semiconductor bodies 2 and onto the substrate 9, wherein the insulating layer 6 covers vertical surfaces of the semiconductor bodies 2 and the trench or trenches 20 arranged laterally to the semiconductor bodies 2.In particular, the insulating layer penetrates into the patterned substrate 9 such that the insulating layer 6 is anchored to the substrate 9 additionally due to the patterned surface 91 of the substrate 9.The insulating layer 6 may also be applied to cover the dielectric layer 5 and the contact structure 7, in particular the second contact area 72, such that a rear side 102 of the component is formed, wherein the rear side 102 is substantially flat, at least outside the recess or recesses 24.The rear side 102 is formed, for example, partially by surfaces of the insulating layer 6 and partially by surfaces of the first and second contact area 71 and 72.On the rear side 102, the first contact area 71 and the second contact area 72 are partially exposed and are electrically contactable.", "After applying the insulating layer 6, a plurality of tethers 63 are formed by structuring the insulating layer 6 at least in a regions covering the trench 20 or trenches.", "The tethers 63 are, in particular, parts of the insulating layer 6 which are arranged laterally to their associated semiconductor body 2.In top view onto the substrate 9, the semiconductor body 2 preferably does not have any overlaps with the tethers 63.The tethers 63 are formed to mechanically fix the semiconductor body 2 to the substrate 9.The tethers 63 may contain a dielectric material such as silicon nitride or silicon oxide, for example, silicon dioxide.", "For structuring the insulating layer 6 covering the trenches 20, a lithography process and/or an etching process may be used.", "In FIG.", "6B, the contact structure 7 comprising the first contact area 71, the via 70 and the second contact area 72 on the rear surface 102 is shown.", "Vertical surfaces of each semiconductor body 2 are covered by the insulating layer 6.The insulating layer 6 is structured into a plurality of laterally separated insulating layers 6 associated with different semiconductor bodies 2.Each semiconductor body 2 comprises on its lateral sides at least one or a plurality of the tethers 63.The insulating layer 6 is structured in regions covering the trenches 20 in such a way that tethers 63 associated with different semiconductor bodies 2 are disconnected.", "This simplifies the process of lifting up any individual semiconductor body 2 without having influence on its neighboring semiconductor bodies 2.In FIG.", "6C, an anchor bar 64 is formed between the semiconductor bodies 2 by structuring the insulating layer 6 in the region covering the trench 20.By way of example, the anchor bar extends along a row of the semiconductor bodies 2 along a lateral direction.", "A plurality of anchor bars 64 may be formed in regions of the trenches 20 between the semiconductor bodies 2.The tethers 63 are connected to the anchor bar 64.In this case neighboring semiconductor bodies 2 may be mechanically connected to each other by the tethers 63 and the anchor bars 64.The tethers 63 and the anchor bars 64 may be designed to take advantage, for example, of a directional etching method which is used for locally detaching the substrate 9 from the semiconductor bodies 2.In FIG.", "7A, the substrate 9 is separated from the semiconductor bodies 2.This can be performed by a laser lift-off process.", "Radiation S can be introduced into the semiconductor bodies 2, in particular into the first semiconductor layers 21 regionally through the substrate 9, such that the first semiconductor layers 21 of the semiconductor bodies 2, in particular of all semiconductor bodies 2 are locally detached from the substrate 9.During the step of separating the substrate 9 the semiconductor bodies 2 are held in place by the tethers 63 which remain attached to the substrate 9.Additionally, a stabilizing carrier 81 may be used which is attached to the rear sides 102 of the semiconductor bodies 2.After detaching the substrate 9 from the semiconductor bodies 2, the first semiconductor layers 21 of the semiconductor bodies 2 are preferably completely separated from the substrate 9, while the tethers 63 remain at least partially attached to the substrate 9.In FIG.", "7B, an etching method may be used for detaching the substrate 9 from the semiconductor bodies 2.For example, the semiconductor body 2 is under-etched by a wet etchant E, which etches the surface 91 of the substrate 9 and/or the first main surface 201 of the semiconductor body 2.For example, a directional etching method is used, wherein the etchant only etches regions covered by the semiconductor body 2.In particular, the tethers 63 and/or the anchor bars 64 are not etched.", "For example, the substrate 9 is a silicon substrate.", "In this case, the tethers 63 and 64 are designed in such a way that the substrate 9 is not etched perpendicular to the anchor bars 64, that is etched only along a lateral direction parallel to the anchor bars 64.For example, a hot wet etchant such as KOH is used for directional etching of the silicon substrate along a direction parallel to the anchor bars 64.In particular, the wet etchant like KOH selectively etches the silicon substrate 9 along <110> directions and is arrested in <112> directions in a (111) plane.", "It is also possible to use an etchant which etches the first semiconductor layer 21 or both the first semiconductor layer 21 and the substrate 9.By under-etching the semiconductor bodies 2, the substrate 9 may be locally detached from the semiconductor bodies 2, wherein the tethers 63 and/or the anchor bars 64 remain at least partially attached to the substrate 9 (FIG.", "7C).", "Using an etchant such as KOH, the first main surface 201 is patterned resulting in an optimal light extraction surface 201.It is also possible to use a combination of two etchants in sequence, one of which is used to etch the substrate 9 and the other etchant is used for patterning the first main surfaces 201 of the semiconductor bodies facing the substrate 9.In FIG.", "8A, a stamp 82 is attached onto the rear side 102 after the stabilizing area 81 has been removed.", "One semiconductor body 2 having one first semiconductor layer 21, one second semiconductor layer 22 and one active region 23 together with the associated contact structure 7 having the via 70 may be selectively picked up by the stamp and lifted from the substrate 9 such that the tethers 63 are separated from the substrate 9.For instance, the tethers 63 are mechanically broken or released from the substrate 9.It is possible that the tethers 63, or at least some remnants of the tethers 63 are detached from the substrate (FIG.", "8B), so that the insulating layer 6 still comprises the tethers 63 or at least some remnants of the tethers 63 after the semiconductor body 2 has been completely removed from the substrate 9.It is also possible to selectively pick up a plurality of semiconductor bodies 2 simultaneously.", "In FIG.", "9A the semiconductor body 2, together with the associated contact structure 7 is transferred to a carrier 1.The semiconductor body 2 is for instance printed onto the carrier 1 such that the patterned first main surface 201 faces the carrier 1.The first main surface 201 is in particular free of any electrical contacts.", "The carrier 1 is formed, for example, as a light transmissive carrier.", "The carrier 1 comprises a connecting layer 13 which is a transparent layer, for instance an adhesive or an epoxy layer.", "After applying the semiconductor body 2 on the carrier 1, the connecting layer 13 may be partially removed and cured.", "The connecting layer 13 fixes the semiconductor body 2 to the carrier 1.The carrier 1 comprises a further mirror 10 or a plurality of further mirrors 10 which may be embedded into the carrier 1.The semiconductor body 2 is arranged on the carrier 1 in a way such that the further mirror 10 or the further mirrors 10 are arranged sideways from the semiconductor body 2.In top view the mirror layer 3, which is disposed on the side of the second main surface 202 of the semiconductor body 2 and the further mirror layers 10 are in particular free of overlaps.", "After applying the semiconductor body 2 onto the carrier 1, the connecting layer 13 may be partially removed and cured.", "After removing the stamp 82, a semiconductor component 100 as shown in FIG.", "9A may be electrically connected to an external electric source by means of the first contact area 71 and the second contact area 72 on the rear side 102 of the semiconductor component 100.FIG.", "9B schematically illustrates a further exemplary embodiment of the semiconductor component 100.This embodiment corresponds substantially to the embodiment of the semiconductor component 100 in FIG.", "9A.", "In contrast thereto, the insulating layer 6 comprises a tether 63 or remnant of the tether 63 which is embedded into the connecting layer 13.The tether 63 or remnant of the tether 63 may serve as an additional lateral anchoring structure which enhances the mechanical stability of the connection between the carrier 1 and the semiconductor body 2.It is also possible that the semiconductor component wo comprises a plurality of tethers 63 or remnants of tethers 63 which are embedded in the connecting layer 13.FIG.", "10 schematically illustrates a further exemplary embodiment of the semiconductor component which substantially corresponds to the embodiment in FIG.", "9A.", "In contrast thereto, the contact structure 7 further comprises a first contact layer 710, a second contact layer 720, a first contact path 721 and a second contact path 722, wherein the first contact layer 710 and the second contact layer 720 are disposed laterally from the semiconductor body 2 on the carrier 1.The first contact layer 710 is electrically connected to the first contact area 71 by the first contact path 721 covering a vertical surface of the semiconductor body 2.The second contact layer 720 is electrically connected to the second contact area 72 by the second contact path 722 covering a vertical surface of the semiconductor body 2.It is also possible that the semiconductor component wo is covered by an additional passivation layer (not shown) which covers, for example, parts of the contact structure 7.In FIG.", "11, the semiconductor component wo comprises phosphor particles 11 and/or scattering particles 12.The phosphor particles 11 and/or the scattering particles 12 may be embedded into a main body of the carrier 1.The carrier 1 comprises a radiation passage area 101 on a side being remote from the semiconductor body 2.Electromagnetic radiation emitted by the active region 23 may be absorbed and re-emitted by the phosphor particles ii and scattered by the scattering particles 12 before leaving the semiconductor component boo, for example, at the radiation passage area 101.It is also possible that the phosphor particles 11 and/or the scattering particles 12 are embedded into the connecting layer 13 or into a layer disposed between the semiconductor body 2 and the carrier 1 or disposed on the radiation passage area 101 of the carrier 1.FIG.", "12 illustrates a device comprising a plurality of semiconductor components 100, wherein the carriers of all the semiconductor components 100 are formed as a single common light transmissive carrier 1.The semiconductor bodies 2 may be arranged in a plurality of rows and columns on the common light transmissive carrier 1.In particular, a plurality of semiconductor bodies 2 may be applied onto the common carrier 1 simultaneously or one after the other.", "The device may comprise a plurality of further mirror layers 10 which are embedded in the common carrier 1 and arranged between the columns and rows of the semiconductor bodies 2.By way of example, in top view, the mirror layers 3 of semiconductor bodies 2 and the further mirror layers 10 of the common carrier are free of overlaps.", "FIGS.", "13A to 13E illustrate some further steps of a method for producing a plurality of semiconductor components 100.The production step illustrated in FIG.", "13A corresponds essentially to the production step described in FIG.", "1.In contrast thereto, the substrate 9 comprises a surface 91 which is not patterned but flat.", "The production step illustrated in FIG.", "13B corresponds substantially to the production step illustrated in FIG.", "6A.", "In contrast thereto, the tethers 63 are formed on the flat surface 91 of the substrate 9.The production step described in FIG.", "13C corresponds substantially to the method step illustrated in FIG.", "13B.", "In contrast thereto, the insulating layer 6 covers the first contact area 71, the second contact area 72 and the via 70 in particular completely, such that the rear side 102 is formed in particular only by an outer surface of the insulating layer 6.The rear side 102 can be formed especially flat in a simplified way, so that in following production steps the stabilizing carrier 81 or the stamp 82 may be easily attached to the semiconductor bodies 2 at the rear side 102.For electrically contacting the component 100, the insulating layer 6 may be removed partially, so that the first and the second contact area 71 and 72 are exposed at least partially.", "The production step illustrated in FIG.", "13D corresponds substantially to the production step described in FIG.", "13D.", "In contrast thereto, the trench 20 or a plurality of trenches 20 are formed in that way that their bottom surfaces are formed partially by exposed portions of the first semiconductor layer 21.The tethers 63 and/or the anchor bars 64 are formed in this case partially by the insulating layer 6 and partially by the first semiconductor layer 21.By doing so the mechanical strength of the tethers 63 and the anchor bars 64 is increased.", "The method step illustrated in FIG.", "13E corresponds substantially to the method step described in FIG.", "7B.", "In contrast thereto, the semiconductor layer sequence 200 has been grown onto a plane or flat surface 91 of the substrate 9, wherein the first main surfaces 201 of the semiconductor bodies 2 are patterned during or after the process of under-etching the semiconductor bodies 2 locally detaching them from the substrate 9.For detaching the substrate 9 from the semiconductor bodies 2 and for patterning the first main surfaces 201, one single etchant or a combination of at least two or more etchants may be used.", "The patterning of the first main surfaces 201 may be performed, while the semiconductor bodies 2 are still connected to the substrate 9 by means of the tethers 63.Using tethers for binding semiconductor bodies to a growth substrate, wherein the tethers are formed within mesa trenches separating the semiconductor bodies, the semiconductor bodies may be held in place during the process of detaching the growth substrate, then selectively picked up and transferred to a carrier, wherein no extra release layers are needed.", "By using the tethers, the method for producing a plurality of semiconductor components may be simplified, resulting in a reduction of production costs.", "While this invention has been described with reference to illustrative embodiments, this description is not intended to be construed in a limiting sense.", "Various modifications and combinations of the illustrative embodiments, as well as other embodiments of the invention, will be apparent to persons skilled in the art upon reference to the description.", "It is therefore intended that the appended claims encompass any such modifications or embodiments." ] ]
Patent_15875955
[ [ "GREASE-LIKE GEL FOR REPELLING INSECTS AND PREVENTING UNDESIRABLE BEHAVIOR IN HOOFED ANIMALS", "Grease-like compositions are provided for repelling insects and preventing undesirable behavior in hoofed animals.", "The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin." ], [ "1-20.", "(canceled) 21.An insect or hoofed animal repelling composition, comprising: 70 to 95 wt.", "% of a base oil selected from the group consisting of white oil, polyalphaolefins, glycols, polyalkylene glycols, alkylated naphthalenes, alkylated benzenes, esters and combinations thereof; 3 to 20 wt.", "% of a thickening agent; 2.0 to 20.0 wt.", "% of a tackifying polymer selected from the group consisting of polybutene, polyalphaolefin, ethylene/propylene copolymer, methacrylate, polyisobutylene, and combinations thereof; 0.005 to 0.5 wt.", "% of a repellent agent selected from the group consisting of capsaicin, piperine, allyl isothiocyanate, allicin, and combinations thereof; and 0.25 to 5 wt.", "% of a solubility improving additive.", "22.The composition of claim 21, wherein the base oil is white oil.", "23.The composition of claim 21, wherein the repellent agent comprises capsaicin.", "24.The composition of claim 21, wherein the repellent agent comprises piperine.", "25.The composition of claim 21, wherein the repelling composition comprises from 1.0-2.0 wt.", "% olefin copolymer as a component of the tackifying polymer.", "26.The composition of claim 21, wherein the thickening agent is an inorganic thickener.", "27.The composition of claim 26, wherein the inorganic thickener is selected from the group consisting of fumed silica, clay, and polytetrafluoroethylene.", "28.The composition of claim 21, wherein the thickening agent is an organic thickener.", "29.The composition of claim 28, wherein the organic thickener is selected from the group consisting of fatty acid complexes of aluminum, lithium, calcium, calcium sulfonate, sodium, titanium, and combinations thereof.", "30.The composition of claim 21, wherein the tackifying polymer has a viscosity at 100° C. of 2500 cSt or more." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Nontoxic insect repellents are a fast growing segment of the building improvement industry, food processing, and food preparation areas.", "Insects are carriers of communicable diseases, and thus preventing them from resting or congregating on the interior or exterior structures of public buildings is particularly important because of health and sanitation concerns.", "Compositions that are effective in repelling insects, while exhibiting acceptable characteristics in terms of appearance, odor, and the like, are not readily formulated.", "If the composition has a strong repellent odor, it can actually be offensive to people within a short distance of the composition, thus reducing the likelihood that the composition will be tolerable in public places.", "If the repellent component is too weak or insufficiently dispersed in the composition, the composition will not be sufficiently effective.", "If a composition does not remain adhered to an insect's exoskeleton after initial contact, the repellent in the composition may not take full effect.", "There are a number of products that have been employed to repel birds.", "In U.S. Patent Publication No.", "2005-0025796, multiple repellent agents are used in a bird repellent composition.", "Capsaicin and menthol are used, in addition to carbomer gel, thickener, and water.", "Another existing composition that contains capsaicin for repelling birds is marketed under the trademark Tanglefoot Bird Repellent™ by The Tanglefoot Company of Grand Rapids, Michigan.", "It is composed of one repelling agent and one combined thickening, filling and dispersing agent.", "However, the composition lacks sufficient dispersion of the repelling agent because it has insufficient types of dispersal agents in the composition to provide maximum dispersal of the repellent.", "It also lacks sufficient tackifying qualities to sufficiently adhere the composition to the targeted species birds.", "Nontoxic repellents for rodents (e.g., mice, rats, moles, voles, squirrels, chipmunks, and the like) are also commercially available.", "Such nontoxic formulations can emit the odor of predators (coyotes, foxes) or emit odors that are unpleasant to rodents (citronella, peppermint, menthol)." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>A grease-like gel that can be applied to any interior or exterior surface to deter insect infestation is of great practical convenience and economic advantage to the building industry.", "Nontoxic deterrents that provide long-lasting effect while not emitting an odor that is offensive to humans are also desirable.", "In a first aspect, a method of repelling an insect is provided, comprising: applying a repelling composition to a surface, the repelling composition comprising 78.0 to 88.0 wt.", "% of a base oil selected from the group consisting of white oil, polyalphaolefins, glycols, polyalkylene glycols, alkylated naphthalenes, alkylated benzenes, esters and combinations thereof, 5.0 to 12.0 wt.", "% of a thickening agent, 5.0 to 10.0 wt.", "% of a tackifying polymer, 0.025 to 0.10 wt.", "% of a repellent agent selected from the group consisting of capsaicin, piperine, allyl isothiocyanate, allicin, and combinations thereof, and 1.0 to 2.0 wt.", "% of a solubility improving additive, whereby an insect is repelled from the surface.", "In an embodiment of the first aspect, the base oil is white oil.", "In an embodiment of the first aspect, the repellent agent is selected from the group consisting of capsaicin and piperine.", "In an embodiment of the first aspect, the repelling composition comprises from 1.0-2.0 wt.", "% olefin copolymer as a component of the tackifying polymer.", "In an embodiment of the first aspect, the thickening agent is selected from the group consisting of an inorganic or organic thickener.", "In an embodiment of the first aspect, the inorganic thickener is selected from the group consisting of fumed silica, clay, and polytetrafluoroethylene.", "In an embodiment of the first aspect, the organic thickener is selected from the group consisting of fatty acid complexes of aluminum, lithium, calcium, calcium sulfonate, sodium, titanium, and combinations thereof.", "In an embodiment of the first aspect, the tackifying polymer is selected from the group consisting of polyisobutylene, polyalphaolefin, polybutene, and ethylene/propylene copolymer.", "In an embodiment of the first aspect, the solubility improving additive is selected from the group consisting of hexane, chloroform, ethylacetate, ethyl ether, acetonitrile, acetone, and ethanol.", "In an embodiment of the first aspect, the repelling composition comprises 83.9 wt.", "% of white oil; 10.0 wt.", "% of fumed silica; 5.0 wt.", "% of a tackifying polymer selected from the group consisting of polybutene, ethylene/propylene copolymer and polyisobutylene; 1.0 wt.", "% of ethanol; and 0.075 wt.", "% of capsaicin.", "In an embodiment of the first aspect, the repelling composition comprises 78.0 to 88.0 wt.", "% of white oil, 5.0 to 12.0 wt.", "% of fumed silica, 5.0 to 10.0 wt.", "% of a tackifying polymer selected from the group consisting of polyisobutylene, polyalphaolefin, polybutene, ethylene/propylene copolymer, and combinations thereof, 0.025 to 0.10 wt.", "% of capsaicin, and 1.0 to 2.0 wt.", "% of ethanol.", "In an embodiment of the first aspect, the repelling composition comprises 83.9 wt.", "% of white oil, 10.0 wt.", "% of fumed silica, 5.0 wt.", "% of polybutene, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the first aspect, the repelling composition comprises 83.9 wt.", "% of white oil, 10.0 wt.", "% of fumed silica, 5.0 wt.", "% of polyisobutylene, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the first aspect, the repelling composition comprises 83.9 wt.", "% of white oil, 10.0 wt.", "% of fumed silica, 5.0 wt.", "% of ethylene/propylene copolymer, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the first aspect, the repelling composition comprises 82.9 wt.", "% of white base oil, 10.0 wt.", "% of a fumed silica, 5.0 wt.", "% of polyalphaolefin, 1.0 wt.", "% of olefin copolymer, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the first aspect, the repelling composition comprises from 1.0-2.0 wt.", "% olefin copolymer as a component of the tackifying polymer.", "In an embodiment of the first aspect, the repelling composition comprises 82.9 wt.", "% of white base oil, 10.0 wt.", "% of a fumed silica, 5.0 wt.", "% of polyalphaolefin, 1.0 wt.", "% of olefin copolymer, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the first aspect, the insect is a cockroach.", "In an embodiment of the first aspect, the insect is exterminated as a result of contacting the repelling composition.", "In a second aspect, a method of repelling a hoofed animal is provided, comprising: applying a repelling composition to a surface, the repelling composition comprising 78.0 to 88.0 wt.", "% of a base oil selected from the group consisting of white oil, polyalphaolefins, glycols, polyalkylene glycols, alkylated naphthalenes, alkylated benzenes, esters and combinations thereof, 5.0 to 12.0 wt.", "% of a thickening agent, 5.0 to 10.0 wt.", "% of a tackifying polymer, 0.025 to 0.10 wt.", "% of a repellent agent selected from the group consisting of capsaicin, piperine, allyl isothiocyanate, allicin, and combinations thereof, and 1.0 to 2.0 wt.", "% of a solubility improving additive, whereby a hoofed animal is repelled from the surface.", "In an embodiment of the second aspect, the base oil is white oil.", "In an embodiment of the second aspect, the repellent agent is selected from the group consisting of capsaicin and piperine.", "In an embodiment of the second aspect, the repelling composition comprises from 1.0-2.0 wt.", "% olefin copolymer as a component of the tackifying polymer.", "In an embodiment of the second aspect, the thickening agent is selected from the group consisting of an inorganic or organic thickener.", "In an embodiment of the second aspect, the inorganic thickener is selected from the group consisting of fumed silica, clay, and polytetrafluoroethylene.", "In an embodiment of the second aspect, the organic thickener is selected from the group consisting of fatty acid complexes of aluminum, lithium, calcium, calcium sulfonate, sodium, titanium, and combinations thereof.", "In an embodiment of the second aspect, the tackifying polymer is selected from the group consisting of polyisobutylene, polyalphaolefin, polybutene, and ethylene/propylene copolymer.", "In an embodiment of the second aspect, the solubility improving additive is selected from the group consisting of hexane, chloroform, ethylacetate, ethyl ether, acetonitrile, acetone, and ethanol.", "In an embodiment of the second aspect, the repelling composition comprises 83.9 wt.", "% of white oil; 10.0 wt.", "% of fumed silica; 5.0 wt.", "% of a tackifying polymer selected from the group consisting of polybutene, ethylene/propylene copolymer and polyisobutylene; 1.0 wt.", "% of ethanol; and 0.075 wt.", "% of capsaicin.", "In an embodiment of the second aspect, the repelling composition comprises 78.0 to 88.0 wt.", "% of white oil, 5.0 to 12.0 wt.", "% of fumed silica, 5.0 to 10.0 wt.", "% of a tackifying polymer selected from the group consisting of polyisobutylene, polyalphaolefin, polybutene, ethylene/propylene copolymer, and combinations thereof, 0.025 to 0.10 wt.", "% of capsaicin, and 1.0 to 2.0 wt.", "% of ethanol.", "In an embodiment of the second aspect, the repelling composition comprises 83.9 wt.", "% of white oil, 10.0 wt.", "% of fumed silica, 5.0 wt.", "% of polybutene, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the second aspect, the repelling composition comprises 83.9 wt.", "% of white oil, 10.0 wt.", "% of fumed silica, 5.0 wt.", "% of polyisobutylene, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the second aspect, the repelling composition comprises 83.9 wt.", "% of white oil, 10.0 wt.", "% of fumed silica, 5.0 wt.", "% of ethylene/propylene copolymer, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the second aspect, the repelling composition comprises 82.9 wt.", "% of white base oil, 10.0 wt.", "% of a fumed silica, 5.0 wt.", "% of polyalphaolefin, 1.0 wt.", "% of olefin copolymer, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the second aspect, the repelling composition comprises from 1.0-2.0 wt.", "% olefin copolymer as a component of the tackifying polymer.", "In an embodiment of the second aspect, the repelling composition comprises 82.9 wt.", "% of white base oil, 10.0 wt.", "% of a fumed silica, 5.0 wt.", "% of polyalphaolefin, 1.0 wt.", "% of olefin copolymer, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the second aspect, the hoofed animal is a horse.", "In an embodiment of the second aspect, repelling the hoofed animal comprises deterring the hoofed animal from at least one undesirable behavior selected from the group consisting of cribbing, wood-chewing, and removing bandages.", "In an embodiment of the second aspect, repelling the hoofed animal comprises deterring the hoofed animal from cribbing.", "In an embodiment of the second aspect, repelling the hoofed animal comprises deterring the hoofed animal from removing bandages.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "INCORPORATION BY REFERENCE TO RELATED APPLICATIONS Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57.This application is a continuation of U.S. application Ser.", "No.", "15/230,258, filed Aug. 5, 2016, which is a continuation of U.S. application Ser.", "No.", "14/796,921, filed Jul.", "10, 2015, now U.S. Pat.", "No.", "9,439,418, which is a continuation of U.S. application Ser.", "No.", "14/491,837, filed Sep. 19, 2014, now U.S. Pat.", "No.", "9,107,407, which is a continuation of U.S. patent application Ser.", "No.", "14/183,412, filed Feb. 18, 2014, now U.S. Pat.", "No.", "8,871,814, which is a continuation of U.S. patent application Ser.", "No.", "13/439,631, filed Apr.", "4, 2012, now U.S. Pat.", "No.", "8,697,752, which is a continuation-in-part of U.S. patent application Ser.", "No.", "13/082,323, filed Apr.", "7, 2011, now U.S. Pat.", "No.", "8,735,427, which claims the benefit of U.S.", "Provisional Application No.", "61/322,779 filed Apr.", "9, 2010 and U.S.", "Provisional Application No.", "61/355,071, filed Jun.", "15, 2010.Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification.", "FIELD OF THE INVENTION Grease-like compositions are provided for repelling insects and preventing undesirable behavior in hoofed animals.", "The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.", "BACKGROUND OF THE INVENTION Nontoxic insect repellents are a fast growing segment of the building improvement industry, food processing, and food preparation areas.", "Insects are carriers of communicable diseases, and thus preventing them from resting or congregating on the interior or exterior structures of public buildings is particularly important because of health and sanitation concerns.", "Compositions that are effective in repelling insects, while exhibiting acceptable characteristics in terms of appearance, odor, and the like, are not readily formulated.", "If the composition has a strong repellent odor, it can actually be offensive to people within a short distance of the composition, thus reducing the likelihood that the composition will be tolerable in public places.", "If the repellent component is too weak or insufficiently dispersed in the composition, the composition will not be sufficiently effective.", "If a composition does not remain adhered to an insect's exoskeleton after initial contact, the repellent in the composition may not take full effect.", "There are a number of products that have been employed to repel birds.", "In U.S. Patent Publication No.", "2005-0025796, multiple repellent agents are used in a bird repellent composition.", "Capsaicin and menthol are used, in addition to carbomer gel, thickener, and water.", "Another existing composition that contains capsaicin for repelling birds is marketed under the trademark Tanglefoot Bird Repellent™ by The Tanglefoot Company of Grand Rapids, Michigan.", "It is composed of one repelling agent and one combined thickening, filling and dispersing agent.", "However, the composition lacks sufficient dispersion of the repelling agent because it has insufficient types of dispersal agents in the composition to provide maximum dispersal of the repellent.", "It also lacks sufficient tackifying qualities to sufficiently adhere the composition to the targeted species birds.", "Nontoxic repellents for rodents (e.g., mice, rats, moles, voles, squirrels, chipmunks, and the like) are also commercially available.", "Such nontoxic formulations can emit the odor of predators (coyotes, foxes) or emit odors that are unpleasant to rodents (citronella, peppermint, menthol).", "SUMMARY OF THE INVENTION A grease-like gel that can be applied to any interior or exterior surface to deter insect infestation is of great practical convenience and economic advantage to the building industry.", "Nontoxic deterrents that provide long-lasting effect while not emitting an odor that is offensive to humans are also desirable.", "In a first aspect, a method of repelling an insect is provided, comprising: applying a repelling composition to a surface, the repelling composition comprising 78.0 to 88.0 wt.", "% of a base oil selected from the group consisting of white oil, polyalphaolefins, glycols, polyalkylene glycols, alkylated naphthalenes, alkylated benzenes, esters and combinations thereof, 5.0 to 12.0 wt.", "% of a thickening agent, 5.0 to 10.0 wt.", "% of a tackifying polymer, 0.025 to 0.10 wt.", "% of a repellent agent selected from the group consisting of capsaicin, piperine, allyl isothiocyanate, allicin, and combinations thereof, and 1.0 to 2.0 wt.", "% of a solubility improving additive, whereby an insect is repelled from the surface.", "In an embodiment of the first aspect, the base oil is white oil.", "In an embodiment of the first aspect, the repellent agent is selected from the group consisting of capsaicin and piperine.", "In an embodiment of the first aspect, the repelling composition comprises from 1.0-2.0 wt.", "% olefin copolymer as a component of the tackifying polymer.", "In an embodiment of the first aspect, the thickening agent is selected from the group consisting of an inorganic or organic thickener.", "In an embodiment of the first aspect, the inorganic thickener is selected from the group consisting of fumed silica, clay, and polytetrafluoroethylene.", "In an embodiment of the first aspect, the organic thickener is selected from the group consisting of fatty acid complexes of aluminum, lithium, calcium, calcium sulfonate, sodium, titanium, and combinations thereof.", "In an embodiment of the first aspect, the tackifying polymer is selected from the group consisting of polyisobutylene, polyalphaolefin, polybutene, and ethylene/propylene copolymer.", "In an embodiment of the first aspect, the solubility improving additive is selected from the group consisting of hexane, chloroform, ethylacetate, ethyl ether, acetonitrile, acetone, and ethanol.", "In an embodiment of the first aspect, the repelling composition comprises 83.9 wt.", "% of white oil; 10.0 wt.", "% of fumed silica; 5.0 wt.", "% of a tackifying polymer selected from the group consisting of polybutene, ethylene/propylene copolymer and polyisobutylene; 1.0 wt.", "% of ethanol; and 0.075 wt.", "% of capsaicin.", "In an embodiment of the first aspect, the repelling composition comprises 78.0 to 88.0 wt.", "% of white oil, 5.0 to 12.0 wt.", "% of fumed silica, 5.0 to 10.0 wt.", "% of a tackifying polymer selected from the group consisting of polyisobutylene, polyalphaolefin, polybutene, ethylene/propylene copolymer, and combinations thereof, 0.025 to 0.10 wt.", "% of capsaicin, and 1.0 to 2.0 wt.", "% of ethanol.", "In an embodiment of the first aspect, the repelling composition comprises 83.9 wt.", "% of white oil, 10.0 wt.", "% of fumed silica, 5.0 wt.", "% of polybutene, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the first aspect, the repelling composition comprises 83.9 wt.", "% of white oil, 10.0 wt.", "% of fumed silica, 5.0 wt.", "% of polyisobutylene, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the first aspect, the repelling composition comprises 83.9 wt.", "% of white oil, 10.0 wt.", "% of fumed silica, 5.0 wt.", "% of ethylene/propylene copolymer, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the first aspect, the repelling composition comprises 82.9 wt.", "% of white base oil, 10.0 wt.", "% of a fumed silica, 5.0 wt.", "% of polyalphaolefin, 1.0 wt.", "% of olefin copolymer, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the first aspect, the repelling composition comprises from 1.0-2.0 wt.", "% olefin copolymer as a component of the tackifying polymer.", "In an embodiment of the first aspect, the repelling composition comprises 82.9 wt.", "% of white base oil, 10.0 wt.", "% of a fumed silica, 5.0 wt.", "% of polyalphaolefin, 1.0 wt.", "% of olefin copolymer, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the first aspect, the insect is a cockroach.", "In an embodiment of the first aspect, the insect is exterminated as a result of contacting the repelling composition.", "In a second aspect, a method of repelling a hoofed animal is provided, comprising: applying a repelling composition to a surface, the repelling composition comprising 78.0 to 88.0 wt.", "% of a base oil selected from the group consisting of white oil, polyalphaolefins, glycols, polyalkylene glycols, alkylated naphthalenes, alkylated benzenes, esters and combinations thereof, 5.0 to 12.0 wt.", "% of a thickening agent, 5.0 to 10.0 wt.", "% of a tackifying polymer, 0.025 to 0.10 wt.", "% of a repellent agent selected from the group consisting of capsaicin, piperine, allyl isothiocyanate, allicin, and combinations thereof, and 1.0 to 2.0 wt.", "% of a solubility improving additive, whereby a hoofed animal is repelled from the surface.", "In an embodiment of the second aspect, the base oil is white oil.", "In an embodiment of the second aspect, the repellent agent is selected from the group consisting of capsaicin and piperine.", "In an embodiment of the second aspect, the repelling composition comprises from 1.0-2.0 wt.", "% olefin copolymer as a component of the tackifying polymer.", "In an embodiment of the second aspect, the thickening agent is selected from the group consisting of an inorganic or organic thickener.", "In an embodiment of the second aspect, the inorganic thickener is selected from the group consisting of fumed silica, clay, and polytetrafluoroethylene.", "In an embodiment of the second aspect, the organic thickener is selected from the group consisting of fatty acid complexes of aluminum, lithium, calcium, calcium sulfonate, sodium, titanium, and combinations thereof.", "In an embodiment of the second aspect, the tackifying polymer is selected from the group consisting of polyisobutylene, polyalphaolefin, polybutene, and ethylene/propylene copolymer.", "In an embodiment of the second aspect, the solubility improving additive is selected from the group consisting of hexane, chloroform, ethylacetate, ethyl ether, acetonitrile, acetone, and ethanol.", "In an embodiment of the second aspect, the repelling composition comprises 83.9 wt.", "% of white oil; 10.0 wt.", "% of fumed silica; 5.0 wt.", "% of a tackifying polymer selected from the group consisting of polybutene, ethylene/propylene copolymer and polyisobutylene; 1.0 wt.", "% of ethanol; and 0.075 wt.", "% of capsaicin.", "In an embodiment of the second aspect, the repelling composition comprises 78.0 to 88.0 wt.", "% of white oil, 5.0 to 12.0 wt.", "% of fumed silica, 5.0 to 10.0 wt.", "% of a tackifying polymer selected from the group consisting of polyisobutylene, polyalphaolefin, polybutene, ethylene/propylene copolymer, and combinations thereof, 0.025 to 0.10 wt.", "% of capsaicin, and 1.0 to 2.0 wt.", "% of ethanol.", "In an embodiment of the second aspect, the repelling composition comprises 83.9 wt.", "% of white oil, 10.0 wt.", "% of fumed silica, 5.0 wt.", "% of polybutene, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the second aspect, the repelling composition comprises 83.9 wt.", "% of white oil, 10.0 wt.", "% of fumed silica, 5.0 wt.", "% of polyisobutylene, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the second aspect, the repelling composition comprises 83.9 wt.", "% of white oil, 10.0 wt.", "% of fumed silica, 5.0 wt.", "% of ethylene/propylene copolymer, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the second aspect, the repelling composition comprises 82.9 wt.", "% of white base oil, 10.0 wt.", "% of a fumed silica, 5.0 wt.", "% of polyalphaolefin, 1.0 wt.", "% of olefin copolymer, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the second aspect, the repelling composition comprises from 1.0-2.0 wt.", "% olefin copolymer as a component of the tackifying polymer.", "In an embodiment of the second aspect, the repelling composition comprises 82.9 wt.", "% of white base oil, 10.0 wt.", "% of a fumed silica, 5.0 wt.", "% of polyalphaolefin, 1.0 wt.", "% of olefin copolymer, 1.0 wt.", "% of ethanol, and 0.075 wt.", "% of capsaicin.", "In an embodiment of the second aspect, the hoofed animal is a horse.", "In an embodiment of the second aspect, repelling the hoofed animal comprises deterring the hoofed animal from at least one undesirable behavior selected from the group consisting of cribbing, wood-chewing, and removing bandages.", "In an embodiment of the second aspect, repelling the hoofed animal comprises deterring the hoofed animal from cribbing.", "In an embodiment of the second aspect, repelling the hoofed animal comprises deterring the hoofed animal from removing bandages.", "DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT The following description and examples illustrate a preferred embodiment of the present invention in detail.", "Those of skill in the art will recognize that there are numerous variations and modifications of this invention that are encompassed by its scope.", "Accordingly, the description of a preferred embodiment should not be deemed to limit the scope of the present invention.", "A repellent composition based on a grease-like gel composition for use on exterior and interior surfaces of a structure, such as homes, restaurants, and office buildings is provided.", "The repellent composition is particularly preferred for use on insects (e.g., cockroaches, ants such as carpenter ants and moisture ants, clothes moths, silverfish, clover mites, bedbugs, termites, carpet beetles, crickets, fleas, dust mites, flies, golden buprestid, house centipede, mosquitoes, powder post beetles, psocids, booklice, spider beetles, granary and rice weevils, flour beetles, meal moths, firebrats, drug store beetles, saw-toothed grain beetles, and the like).", "Unlike conventional repellents that rely on odiferous components such as menthol, the repellents of preferred embodiments rely on a different mechanism of action and thus can be odor-free.", "The repellents of preferred embodiments work by the insect making contact with the composition, which contains capsaicin, white pepper, or other components that produce a strong burning sensation in the mouth upon ingestion, but which are odorless or relatively odor-free.", "Use of menthol and other odiferous components conventionally employed in repellents is avoided, as such components can reduce the effectiveness of a gel repellent composition because it discourages insects from making physical contact with the composition.", "Any of the repellents described herein are also effective at preventing undesirable behavior in hoofed animals (Ungulates), including perissodactyla, artiodactyla, tubulidentata, hyracoidean, sirenia, and proboscidea.", "For example, any of the repellents described herein can be used to prevent undesirable behavior in including horse, zebra, donkey, cattle, bison, rhinoceros, camel, hippopotamus, tapir, goat, pig, sheep, giraffe, okapi, moose, elk, deer, antelope, or gazelle.", "For example, any of the repellents described herein can be used to prevent undesirable behavior in horses.", "The undesirable behavior that is deterred includes any behavior that causes damage to property or the hoofed animal.", "For example, the repellents described herein are capable of deterring hoofed animals from cribbing, wood-chewing, and removing bandages.", "Repellent Additive The repellent ingredient of the compositions of preferred embodiments is preferably capsaicin (8-methyl-N-vanillyl-6-nonenamide).", "It is the active component of chili peppers, which are plants belonging to the genus Capsicum.", "It is an irritant for mammals, including humans, and produces a sensation of burning in any tissue with which it comes into contact.", "Capsaicin and several related compounds are called capsaicinoids and are produced as a secondary metabolite by chili peppers.", "Pure capsaicin is a hydrophobic, colorless, odorless, crystalline to waxy compound.", "Capsaicin is the main capsaicinoid in chili peppers, followed by dihydrocapsaicin.", "These two compounds are also about twice as potent to the taste and nerves as the minor capsaicinoids nordihydrocapsaicin, homodihydrocapsaicin, and homocapsaicin.", "Besides the six natural capsaicinoids, one synthetic member of the capsaicinoid family exists, the vanillylamide of n-nonanoic acid.", "Table 1 provides a listing of several capsaicinoids.", "TABLE 1 Scoville Capsaicinoid name Abbrev.", "heat units Chemical structure Capsaicin C 16,000,000 Dihydrocapsaicin DHC 15,000,000 Nordihydrocapsaicin NDHC 9,100,000 Homodihydrocapsaicin HDHC 8,600,000 Homocapsaicin HC 8,600,000 Nonivamide PAVA Other components exhibiting similar properties can also be used as the repellent ingredient of the compositions of preferred embodiments.", "One such preferred component is piperine, the active piquant chemical in white and black pepper.", "Allyl isothiocyanate, the active piquant chemical in mustard, radishes, horseradish, and wasabi can also be employed, as can allicin, the active piquant flavor chemical in uncooked garlic and onions.", "A particularly preferred repellent additive is capsaicin, due to its lack of odor in purified form.", "Piperine also exhibits minimal odor in purified form.", "In applications where odor is not a concern, allyl isothiocyanate and allicin can advantageously be employed.", "While one repellent additive can advantageously be employed, combinations of two or more additives, e.g., capsaicin and piperine, are also suitable for use.", "The repellent additive(s) typically comprise from about 0.005 wt.", "% or less to 0.5 wt.", "% or more of the repellent formulation, preferably from about 0.025 wt.", "% to about 0.1 wt.", "% of the repellent formulation.", "Solubility Improving Additives Repellent additives are preferably employed in purified form; however, in certain embodiments it can be acceptable to provide at least a portion of the repellent additive in a form of powdered vegetable product (e.g., chili powder).", "The repellent additive can be mixed into to the grease base in powder or other solid form, or in a solubilized form.", "To improve the solubility of the repellent additive or other additives in the grease formulation, in certain embodiments it can be preferred to add an activator agent or other solubility improver to the grease base (the term “solubility improving additive” as employed herein is used to collectively refer to both activator agents and solubility improvers).", "Esters, such as polyol esters can optionally be employed as solubility improving additives.", "Alternatively, if the repellent additive is provided in a purified form, the additive can be dissolved or dispersed in a suitable solvent, which is then mixed into the grease base.", "Suitable solvents for capsaicin include, e.g., hexane, chloroform, ethylacetate, ethyl ether, acetonitrile, acetone, and ethanol.", "Ethanol, petroleum ether, and dichloromethane are solvents for piperine.", "Allyl isothiocyanate and allicin are soluble in most organic solvents and are slightly soluble in water.", "While any suitable solvent for the repellent additive can be employed, if desired, ethanol, e.g., denatured ethanol, is generally preferred as the most environmentally acceptable activator agent.", "When ethanol is provided in denatured form, it can contain ethanol in combination with other additives.", "For example, the denatured ethanol may contain about 1-99% ethanol and about 1-99% additives, about 95% ethanol and about 5% additives, about 90% ethanol and about 10% additives, about 75% ethanol and about 25% additives, about 50% ethanol and about 50% additives.", "Additives employed in denatured alcohol include, for example, methanol, isopropyl alcohol, acetone, methyl ethyl ketone, methyl isobutyl ketone, and denatonium.", "In a preferred embodiment, the denatured ethanol contains 95% ethanol and 5% additives.", "The solubility improving additive(s) typically comprise from about 0.25 wt.", "% or less to 5 wt.", "% or more of the repellent formulation, preferably from about 0.5 wt.", "% to about 3 wt.", "% of the repellent formulation, and more preferably from about 1 wt % to about 2 wt % of the repellent formulation.", "Base Oil Carrier The capsaicin or other repelling ingredient is provided in a grease-like base.", "Preferred grease-like bases include one or more base oil or fluid components as a carrier.", "The oil or base fluid may include any number of materials, which are typically divided into two groups: petroleum derived oils; and synthetic fluids, which are generally chemical reaction products.", "Petroleum derived oils include paraffinic oils, naphthenic oils, and aromatic oils.", "Synthetic fluids including polyalphaolefins, glycols, polyalkylene glycols, alkylated naphthalenes, alkylated benzenes, and esters have been used in compounding oil-based products.", "It is generally preferred to employ base oils that are both low cost and exhibit low toxicity.", "Accordingly, light or heavy grade white oil (a transparent, colorless mineral oil composed mainly of C15-C40 alkanes and cyclic paraffins), preferably of a purity suitable for use in food or cosmetics, is preferably employed as a base oil.", "Alternatively, or in addition to mineral oil, vegetable oils can be utilized.", "Vegetable oils are lipids (esters) derived from plants.", "Suitable vegetable oils include, but are not limited to, coconut oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, rapeseed oil, safflower oil, soybean oil, sunflower oil, almond oil, castor oil, cashew oil, hazelnut oil, macadamia oil, mongongo nut oil, pecan oil, pine nut oil, pistachio oil, walnut oil, bottle gourd oil, buffalo gourd oil, pumpkin seed oil, watermelon seed oil, acai oil, blackcurrant seed oil, borage seed oil, evening primrose oil, amaranth oil, apricot oil, apple seed oil, argan oil, artichoke oil, avocado oil, babassu oil, ben oil, borneo tallow nut oil, cape chestnut oil, carob pod oil, cassia oil, cocoa butter oil, cocklebur oil, cohune oil, coriander seed oil, dika oil, false flax oil, flax seed oil, grape seed oil, hemp oil, kapok seed oil, kenaf seed oil, lallemantia oil, marula oil, meadowfoam seed oil, mustard oil, nutmeg butter, okra seed oil, papaya seed oil, perilla seed oil, pequi oil, pine nut oil, poppyseed oil, prune kernel oil, quinoa oil, ramtil oil, rice bran oil, royle oil, sacha inchi oil, tea seed oil, thistle oil, tigernut oil, tomato seed oil, wheat germ oil, algae oil, copaiba, honge oil, jatropha oil, jojoba oil, milk bush, and petroleum nut oil.", "Polyalphaolefins can be employed as base oil.", "Such polyalphaolefins include high viscosity polyalphaolefins as described in U.S. Pat.", "No.", "4,827,064.For example, high viscosity polyalphaolefins possess a higher viscosity index than conventional polyalphaolefins of similar molecular weight.", "High viscosity polyalphaolefins generally exhibit higher film strengths than conventional viscosity polyalphaolefins are generally of higher viscosity than conventional polyalphaolefins of similar molecular weight, but exhibit lower pour points than the corresponding conventional polyalphaolefins.", "The lower pour point of high viscosity polyalphaolefins makes them suitable for use at lower temperatures than conventional polyalphaolefins.", "High viscosity polyalphaolefins also exhibit superior oxidative stability than conventional polyalphaolefins.", "High viscosity polyalphaolefins are characterized by a uniform molecular structure with low branch ratios.", "The branch ratio is the ratio of methyl (—CH3) to methylene (—CH2—) moieties in the molecular structure).", "High viscosity polyalphaolefins typically possess a branch ratio of less than about 0.19, while conventional polyalphaolefins branch possess a branch ratio greater than 0.2.The polymerization reaction by which high viscosity polyalphaolefins are formed is generally highly specific, resulting in a low number of isomers formed.", "The resulting high viscosity polyalphaolefin product oligomers have an atactic molecular structure of mostly head-to-tail attachments, with some head-to-head connections.", "High viscosity polyalphaolefins generally possess an average molecular weight of from about 300 to about 45,000, a carbon number of from about 30 to 1000, and a viscosity at 100° C. of about 3 to about 5000 cSt.", "The viscosity is typically in the range of about 150 to about 3000 cSt at 100° C. The branch ratio is typically less than 0.19.A high viscosity polyalphaolefin is marketed under the trade name SUPERSYN™ by Exxon Mobil Corporation of Houston, Tex.", "Polyalphaolefin base oils suitable for use in formulations of preferred embodiments include EXXON Mobil Corporation's Spectrasyn™ line of polyalphaolefin fluid.", "Examples of Spectrasyn™ polyalphaolefin fluid include Spectrasyn™ 100, Spectrasyn™ 40, Spectrasyn™ 10, Spectrasyn™ 8, Spectrasyn™ 6, Spectrasyn™ 5, Spectrasyn™ 4, Spectrasyn™ 2C, and Spectrasyn™ 2.The viscosities of the Spectrasyn™ polyalphaolefin fluid vary.", "For example, Spectrasyn™ 100 and Spectrasyn™ 40 have relatively high viscosities.", "Spectrasyn™ 100 has a viscosity of 1240 cSt at 104° F., and Spectrasyn™ 40 has a viscosity of 396 cSt at 104° F. Spectrasyn™ 10, Spectrasyn™ 8, Spectrasyn™ 6, Spectrasyn™ 5, Spectrasyn™ 4, Spectrasyn™ 2C, and Spectrasyn™ 2 have relatively low viscosities.", "For example, Spectrasyn™ 10 has a viscosity of 66 cSt at 104° F., Spectrasyn™ 2 has a viscosity of 5 cSt at 104° F., Spectrasyn™ 2C has a viscosity of 6.4 cSt at 104° F., Spectrasyn™ 4 has a viscosity of 19 cSt at 104° F., Spectrasyn™ 5 has a viscosity of 25 cSt at 104° F., Spectrasyn™ 6 has a viscosity of 31 cSt at 104° F., and Spectrasyn™ 8 has a viscosity of 48 cSt at 104° F. The viscosity of the polyalphaolefin can be selected in order to achieve a formulation with desired characteristics.", "Generally, it is preferred to employ a high viscosity polyalphaolefin so as to provide greater structural integrity, weather resistance and stickiness to the repellant formulation.", "Alkylated naphthalene is generally employed as additional base fluid to impart increased thermal and oxidative stability to a grease composition.", "See, e.g., U.S. Pat.", "No.", "5,177,284 and U.S. Pat.", "No.", "5,457,254.Mono or poly substituted alkylated naphthalenes can be employed.", "Similar to the alkylated naphthalenes are the polymers of alkyl benzenes, such as dodecylbenzenes, tetradecylbenzenes, dinonylbenzenes, di-(2-ethyl-hexyl)-benzenes, and the like.", "Alkylated aromatics are formed by the reaction of olefins or alkyl halides with aromatic compounds, such as benzene.", "Suitable alkylated naphthalenes can be obtained from EXXON Mobil Corporation.", "Alkylated naphthalene fluids suitable for use in formulations of preferred embodiments include EXXON Mobil Corporation's Synesstic™ line of alkylated naphthalene.", "Examples of Synesstic™ alkylated naphthalene fluids include Synesstic™ 5 and Synesstic™ 12.Synesstic™ 12 alkylated naphthalene has a viscosity of 109 cSt at 104° F., and Synesstic™ 5 alkylated naphthalene has a viscosity of 29 cSt at 104° F. One preferred class of synthetic fluid bases is that of synthetic polyolefins, particularly hydrogenated polyalphaolefins, although other synthetic polyolefins may be utilized as well.", "Examples of the synthetic hydrocarbon oils which may be utilized as additional synthetic fluid base oils for the formulations of preferred embodiments are preferably saturated.", "Such oils may be prepared by polymerizing unsaturated monomers (e.g., ethylene) and hydrogenating the resulting polymer prior to use to remove any residual unsaturation from the oil.", "Examples of the saturated hydrocarbon and halo-substituted hydrocarbon oils include polyethylenes, polypropylenes, polybutylenes, propylene-isobutylene copolymers, chlorinated polybutylenes, poly(1-hexenes), poly(1-octenes), poly(1-decenes); polyphenyls such as biphenyls, terphenyls, alkylated polyphenyls, and the like; alkylated diphenyl ethers and alkylated diphenyl sulfides and derivatives, including deuterated and hydrogenated derivatives.", "The hydrogenated polyolefins derived from alphaolefins such as ethylene, propylene, 1-butene, and the like are especially preferred for use as additional synthetic base oils.", "In certain embodiments, however, it may be preferred to use a polyolefin derived from a branched chain monomer, for example, isobutylene.", "Dibasic acid esters can be employed as base oils.", "Polyol esters include molecules containing two or more alcohol moieties, such as trimethylolpropane, neopentylglycol, and pentaerythritol esters.", "Synthetic polyol esters are the reaction product of a fatty acid (e.g., derived from either animal or plant sources) and a synthetic polyol.", "Polyol esters have excellent thermal stability and generally resist hydrolysis and oxidation better than other base stocks.", "Naturally occurring triglycerides and vegetable oils, as discussed above, are in the same chemical family as polyol esters.", "Trimethylolpropane esters may include mono, di, and tri esters.", "Neopentyl glycol esters may include mono and di esters.", "Pentaerythritol esters include mono, di, tri, and tetra esters.", "Dipentaerythritol esters may include up to six ester moieties.", "Preferred esters are typically of those of long chain monobasic fatty acids.", "Esters of C20 or higher acids can be employed, e.g., gondoic acid, eicosadienoic acid, eicosatrienoic acid, eicosatetraenoic acid, eicosapentanoic acid, arachidic acid, arachidonic acid, behenic acid, erucic acid, docosapentanoic acid, docosahexanoic acid, or ligniceric acid, or esters of C18 or lower acids, e.g., butyric acid, caproic acid, caprylic acid, capric acid, lauric acid, myristoleic acid, myristic acid, pentadecanoic acid, palmitic acid, palmitoleic acid, hexadecadienoic acid, hexadecatienoic acid, hexadecatetraenoic acid, margaric acid, margroleic acid, stearic acid, linoleic acid, octadecatetraenoic acid, vaccenic acid, or linolenic acid.", "In certain embodiments, it may be preferred to esterify pentaerythritol with a mixture of different acids.", "Particularly preferred synthetic ester oils are the esters of trimethylol propane, trimethylol butane, trimethylol ethane, pentaerythritol and/or dipentaerythritol with one or more monocarboxylic acids containing from about 5 to 10 carbon atoms.", "Polyol polyesters may be obtained by reacting various polyhydroxy compounds with carboxylic acids.", "When the carboxylic acids are dicarboxylic acids, monohydroxy compounds can be substituted for the polyols.", "For example, synthetic esters include the esters of dicarboxylic acids such as phthalic acid, succinic acid, alkyl succinic acid, alkenyl succinic acid, maleic acid, azelaic acid, suberic acid, sebacic acid, fumaric acid, adipic acid, linoleic acid dimer, malonic acid, alkyl malonic acid, alkenyl malonic acid, and the like.", "These dicarboxylic acids may be reacted with alcohols such as, for example, butanol, hexanol, dodecyl alcohol, 2-ethylhexyl alcohol, and the like.", "Specific examples of such esters include dibutyl adipate, di (2-ethylhexyl) sebacate, di-N-hexyl fumarate, dioctyl sebacate, diisooctyl azelate, diisodecyl azelate, dioctyl phthalate, didecyl phthalate, and the like.", "Silicon-based oils including siloxanes, such as polyalkylsiloxane, polyarylsiloxane, polyalkoxysiloxane, and polyaryloxysiloxane oils and silicone oils may also be suitable for use as additional base oils.", "Specific examples of some suitable polysiloxanes include methyl phenyl silicone, methyl tolyl silicone, methyl ethylphenyl silicone, ethyl phenyl silicone, propyl phenyl silicone, butyl phenyl silicone, and hexyl propylphenyl silicone.", "Preferred silicon-based oils also include silicones such as alkyl phenyl silicones.", "Preferred alkyl groups for alkyl phenyl silicones include aliphatic groups, e.g., methyl, propyl, pentyl, hexyl, decyl, and the like; alicyclic groups, e.g., cyclohexyl, cyclopentyl, and the like; aryl groups, e.g., phenyl, naphthyl, and the like; aralkyl groups; and alkaryl groups, e.g., tolyl, xylyl, and the like; and halogenated, oxygen-containing, and nitrogen-containing organyl groups such as halogenated aryl groups, alkyl and aryl ether groups, aliphatic ester groups, organic acid groups, cyanoalkyl groups, and the like.", "The alkyl groups preferably contain from 1 to about 30 carbon atoms.", "Alkyl phenyl silicones are particularly preferred.", "Alkyl phenyl silicones are particularly preferred, especially those having a viscosity of from about 20, 25, 50, 75, 100, 125, or 150 cSt to about 200, 250, 500, 750, 1000, 1250, 1500, 1750, or 2000 cSt at 25° C. Particularly preferred base oils for use in formulations of preferred embodiments include Dow Corning® Brand Silicone Fluids.", "Silicone fluids from Dow Corning are high-performance, liquid lubricating materials that demonstrate excellent performance over a wide temperature range.", "Dow Corning® 200 Fluid, a dimethyl silicone fluid, is available in a range of viscosities (10 cSt or lower to 1,000 cSt or higher).", "Dow Corning® 510 Fluid, a phenyl methyl silicone fluid, is available in 50 cSt or lower to 30,000 cSt or higher viscosities.", "It functions over a wide range of ambient temperatures (from −51° C. to 204° C.).", "Dow Corning® 550 Fluid is a 125 CS phenyl methyl silicone fluid.", "It resists oxidation and has a wide service temperature range (from −40° C. to 232° C.).", "Dow Corning® 710 Fluid is a 500 CS phenyl methyl silicone fluid with excellent heat stability and resistance to evaporation and oxidation, and functions over a wide temperature range (from −18° C. to 260° C.).", "Dow Corning® FS-1265 Fluid is a fluorosilicon fluid with a viscosity of from 300 cSt or less to 10,000 cSt or more.", "It resists oxidation, harsh chemicals, fuels, and high temperatures, and functions over a temperature range of from −40° C. to 204° C.).", "Particularly preferred white, off-white, and translucent white base oils for use in formulations of preferred embodiments include Dow Corning® Brand Silicone Fluids.", "Dow Corning® Brand Silicone Fluids are available in light to heavy consistencies.", "For example, Dow Corning® 7 Release Compound is a white-translucent light consistency dimethyl silicone compound with a service temperature range of −40° C. to 204° C. and a specific gravity at 25° C. of 1.0.Dow Corning® 4 Electrical Insulating Compound is a white-translucent medium consistency dimethyl silicone compound with a service temperature range of −57° C. to 204° C. and a specific gravity at 25° C. of 1.0.Dow Corning® 111 valve lubricant and sealant is a white-translucent heavy consistency dimethyl silicone compound with a service temperature range of −40° C. to 204° C. and a specific gravity at 25° C. of 1.0.The FDA has permitted Dow Corning® 4 and 7 Electrical Insulating Compounds and Dow Corning® 111 valve lubricant and sealant for food contact and they are listed under NSF Standard 51 for food processing, and NSF 51 for potable water applications.", "Another white, off-white, or translucent white base oil for use in formulations of preferred embodiments is Dow Corning® 112 high performance lube/sealant.", "Dow Corning® 112 sealant is a white-translucent stiff grease-like silicone compound containing an inert amorphous silica filler in combination with selected polydimethyl silicone fluids.", "Dow Corning® 112 has a specific gravity at 25° C. of 1.1.serviceability from −40° C. to 232° C., excellent water and oil resistance, good resistance to most chemicals, and low volatility.", "Instead of or in addition to a base oil, a grease can be employed in formulations of preferred embodiment.", "Such greases typically comprise a base oil and a thickener.", "Particularly preferred greases are designated as suitable for food contact or processing, or potable water applications.", "Dow Corning's® Molycote® BG 20 High Performance Synthetic Grease is an example of a grease that can be used instead of or in addition to a base oil in formulations of preferred embodiments.", "Molycote® BG 20 High Performance Synthetic Grease is a beige synthetic polyolester grease with lithium complex thickener.", "Molycote® BG 20's properties include a wide temperature range if −45° C. to 182° C. Polyethers suitable for use as base oils may include polyphenyl ether fluids, preferably those containing from 3 to 7 benzene rings and from 2 to 6 oxygen atoms, wherein the oxygen atoms link the benzene rings, which may be hydrocarbyl-substituted.", "The hydrocarbyl substituents are preferably free of unsaturated hydrocarbon groups.", "The preferred aliphatic substituents include saturated hydrocarbon groups containing from 1 to 6 carbon atoms, such as ethyl, propyl, butyl, and t-butyl groups.", "Preferred aromatic substituents include aryl groups such as phenyl, tolyl, t-butyl phenyl, and alphacumyl.", "Polyphenyl ethers consisting exclusively of chains of from 3 to 7 benzene rings with at least two oxygen atom joining the benzene rings exhibit superior thermal stability, for example, the polyphenyl ethers such as 1-(p-methylphenoxy)-4-phenoxy benzene and 2,4-diphenoxy-1-methyl benzene; 4-ring polyphenyl ethers such as bis[p-(p-methylphenoxy) phenyl] ether and bis[p-(p-t-butylphenoxy) phenyl] ether, and the like.", "Polyalkylene glycols (also referred to as polyalkylene oxides) are polymers of alkylene oxides.", "Polyalkylene oxides and derivatives thereof wherein the terminal hydroxyl groups have been modified by esterification, etherification, and the like, also constitute a class of synthetic lubricating oils that can be utilized as a component of the base oil.", "These oils include those prepared through polymerization of ethylene oxide and propylene oxide, the alkyl and aryl ethers of these polyoxyalkylene polymers such as methyl polyisopropylene glycol ether having an average molecular weight of about 1000, diphenyl ether of polyethylene glycol having a molecular weight of about 500 to 1000, and diethyl ether of polypropylene glycol having a molecular weight of about 1000 to about 1500.Polyalkylene glycols suitable for use in formulations of preferred embodiments include PLURASAFE® Brand Silicone Fluids from BASF.", "The base fluid may contain as its sole component a single base oil or a mixture of two or more base oils (e.g., of different chemical compositions or same category but different characteristics, e.g., different viscosities, viscosity indexes, molecular weights, produced by different manufacturing processes, and the like).", "In certain embodiments, however, it may be preferred to combine one or more high viscosity polyalphaolefins with one or more other mineral or synthetic base fluids.", "The base oil(s) and/or base fluid(s) typically comprise from about 70 wt.", "% or less to about 95 wt.", "% or more of the repellent formulation, preferably from about 75 wt.", "% to about 90 wt.", "% of the repellent formulation.", "Thickener The base oil is thickened into a grease base by addition of a thickener.", "Thickener systems that can be advantageously employed include fumed silica, hydrophobic fumed silica, modified clay, dye and pigment thickeners, thickeners such as carbon black, graphite, polytetrafluoroethylene (PTFE), polyurea, and the like.", "The thickener can be added to the base oil using methods conventionally employed for preparing greases.", "Generally, a base oil is provided, or a blend of base oils is prepared, and then the thickener is added to the base oil with mixing.", "Silica gel is advantageously employed as it can increase the adhesiveness of the composition, thereby increasing the time of contact between the composition and the target insect or hoofed animal.", "Silica gel is a granular, vitreous, highly porous form of silica.", "Silica gel is commonly employed as a food grade desiccant.", "Fumed silica, also known as pyrogenic silica, is a non-crystalline, fine-grain, low density and high surface area silica.", "Fumed silica has a very strong thickening effect.", "Primary particle size is 5-50 nm.", "The particles are non-porous and have a surface of 50-600 m2/g.", "Density 2.2 g/cm3.Fumed silica is made from flame pyrolysis of silicon tetrachloride or from quartz sand vaporized in a 3000° C. electric arc.", "Fumed silica serves as a universal thickening agent, a thickener in milkshakes, and an anticaking agent in powdered foods.", "Like silica gel, it serves as a desiccant.", "Hydrophobic silica is a silica that has hydrophobic groups chemically bonded to the surface.", "Hydrophobic silica can be made both from fumed and precipitated silica.", "The hydrophobic groups are normally alkyl or polydimethylsiloxane chains.", "The toxicological properties of silicas make them desirable thickening agents for the grease bases of preferred embodiments.", "Fumed silicas suitable for use in formulations of preferred embodiments include AEROSIL 972™ manufactured by Degussa Corporation of Orange, Calif. or CABOSIL TS720™ manufactured by Cabot Corporation of Boston, Mass.", "AEROSIL 972™ is a hydrophobic fumed silica after treated with dimethyldichlorosilane.", "AEROSIL 972™ has a specific surface area of about 110±20 m2/g, an approximate tamped density of about 50 g/l, and an average primary particle size of about 16 nm.", "It is preferable that when using AEROSIL 972™, it is preferably present in the repellent formulation at from about 5.0 to 12.0 wt.", "%, and more desirably at about 10.0 wt.", "%.", "CABOSIL TS720™ is an insoluble white powder having a density of 2.2 g/cm3 at 20° C. It is preferable that when using CABOSIL TS720™, it is preferably present in the repellent formulation at from about 5.0 to 12.0 wt.", "%, and more desirably at about 10.0 wt.", "%.", "Soap thickeners prepared by combining one or more fatty acids with one or more metal metal-containing components, e.g., alkali or alkaline earth metal hydroxides, oxide and/or isopropoxides can also be advantageously employed as low cost, low toxicity additives.", "When a soap thickener is employed, the soap itself can be added to the base oil, or the reactants yielding the soap can be added separately to the base oil and allowed to react.", "In certain embodiments it can be desirable to alter the mixing process and/or parameters, or the sequence of addition of components, as is appreciated by one skilled in the art.", "For example, the reactants yielding the soap may be added separately to different base oil components, or different portions of the base oil blend, then the partially additized blend components may be mixed.", "When reactants yielding soap are employed, the reactants are typically added to the base oil blend, and the mixture is heated to saponify the grease.", "After the saponification reaction reaches a sufficient degree of completion, the grease is allowed to cool and the remaining additives are incorporated into the grease.", "Preferred metal containing components include alkaline earth metal hydroxides, such as calcium hydroxide, which exhibits good water resistance.", "Preferred fatty acids generally include those obtained from vegetable sources which contain from 10 to 22 carbon atoms.", "A single fatty acid or two or more fatty acids can be employed.", "Fatty acids containing 18 carbon atoms are particularly preferred, especially stearic acid or 12-hydroxy stearic acid; however, other fatty acids can advantageously be employed, including but not limited to gondoic acid, eicosadienoic acid, eicosatrienoic acid, eicosatetraenoic acid, eicosapentanoic acid, arachidic acid, arachidonic acid, behenic acid, erucic acid, docosapentanoic acid, docosahexanoic acid, ligniceric acid, butyric acid, caproic acid, caprylic acid, capric acid, lauric acid, myristoleic acid, myristic acid, pentadecanoic acid, palmitic acid, palmitoleic acid, hexadecadienoic acid, hexadecatienoic acid, hexadecatetraenoic acid, margaric acid, margroleic acid, stearic acid, linoleic acid, octadecatetraenoic acid, vaccenic acid, and linolenic acid.", "One or more or more additional fatty acids may be employed to provide a more complex structure to the grease with increased cross-linking.", "Although, higher molecular weight acids can provide additional lubricity to the grease, they are generally inferior as additional complexing acids.", "Accordingly, one or more lower molecular weight fatty acids are used, preferably fatty acids containing from 2 to 10 carbon atoms, so as to provide greater cross-linking.", "Especially preferred is acetic acid.", "To form the grease, the preferred alkaline earth (e.g., calcium) oxide or hydroxide is added to the base oil blend.", "Then, the fatty acids are added.", "The saponification reaction occurs upon heating the metal and fatty acids to a suitable temperature, typically about 175° C. The elevated temperature is then maintained, e.g., for about 20 minutes or until the reaction proceeds to a satisfactory degree of completion.", "The mixture is preferably stirred, either continuously or intermittently, during heating.", "After the resulting soap-containing mixture is cooled, the remaining additives are added.", "The preferred metal complex soap thickener is a calcium complex in which the fatty acid complex is formed by the reaction of calcium hydroxide with several organic acids including acetic acid and 12-hydroxystearic acid.", "The thickener(s) typically comprise from about 3 wt.", "% or less to 20 wt.", "% or more of the repellent formulation, preferably from about 4 wt.", "% to about 15 wt.", "% of the repellent formulation.", "Tackifiers The base greases of preferred embodiments may contain various polymers which function as tackifying agents.", "The addition of polymers may add to the viscosity and also to the adhesive qualities of the composition so that the composition can be applied to both horizontal and vertical surfaces.", "The ability to apply the composition to vertical surfaces enhances its utility because this increases the potential number of surfaces on which the composition may be used.", "Useful tackifying agents include polymers like polybutene, polybutylene (e.g., polyisobutylene), olefin copolymers, methacrylates, polyalphaolefins, and ethylene/propylene copolymers.", "Food grade tackifiers are particularly preferred.", "Tackifiers are generally provided in a suitable carrier, e.g., paraffinic oil, naphthenic oil, while oil, or polyalphaolefin, and can include polyisobutylene in white mineral oil and have a viscosity of, e.g., 2500 cSt @ 100° C. or more (e.g., 3000 or 4000 cSt @ 100° C.).", "The tackifier(s) typically comprise from about 2.0 wt.", "% or less to 20 wt.", "% or more of the repellent formulation, preferably from about 3 wt.", "% to about 15 wt.", "% of the repellent formulation.", "Other Additives Other additives as are known in the lubricating arts may also be employed in the base greases of preferred embodiments.", "These include metal deactivators such as benzotriazole, substituted benzotriazole and 2,5-di-mercapto-1,3,4-thiodiazole, which protect ferrous and nonferrous metal surfaces from corrosion.", "The base grease can also include conventional fillers, thickeners, thixotropic agents, antioxidants, corrosion prevention materials, and the like, depending upon the surface to which the repellent formulation is to be applied.", "Solid lubricant components can be added at any suitable step in the grease manufacturing process, for example, when the thickener is added if the thickener is not a metal soap type which is formed by a chemical reaction in the oil.", "Solid additives are preferably added to the grease with sufficient mixing, working, homogenizing, or the like, to ensure a complete, uniform, and thorough dispersion of solid particles.", "Preferably, solid lubricants are added to the grease after the thickener is formed or added.", "Various compounds known for use as oxidation inhibitors can be utilized in grease formulations of various embodiments, advantageously when the compositions are to be employed in contact with oxidation-sensitive materials.", "These include phenolic antioxidants, amine antioxidants, sulfurized phenolic compounds, and organic phosphites, among others.", "Is it especially preferred that the antioxidant includes predominately or entirely either a hindered phenol antioxidant such as 2,6-di-tert-butylphenol, 4-methyl-2,6-di-tert-butylphenol, 2,4-dimethyl-6-tert-butylphenol, 4,4′-methylenebis(2,6-di-tert-butylphenol), and mixed methylene bridged polyalkyl phenols, or an aromatic amine antioxidant such as the cycloalkyl-di-lower alkyl amines (N,N′-di-lower-alkyl phenylenediamines, such as N,N′-di-sec-butyl-p-phenylenediamine, and its analogs), and phenylenediamines, or a combination of one or more such phenolic antioxidants with one or more such amine antioxidants.", "A variety of corrosion inhibitors are also available for use in the grease formulations of various embodiments, advantageously when the compositions are to be employed in contact with corrosion-sensitive materials.", "Corrosion inhibitors include dimer and trimer acids, such as are produced from tall oil fatty acids, oleic acid, linoleic acid, and the like.", "Other useful types of corrosion inhibitors are the alkenyl succinic acid and alkenyl succinic anhydride corrosion inhibitors such as, for example, tetrapropenylsuccinic acid, tetrapropenylsuccinic anhydride, tetradecenylsuccinic acid, tetradecenylsuccinic anhydride, hexadecenylsuccinic acid, hexadecenylsuccinic anhydride, and the like.", "Also useful are the half esters of alkenyl succinic acids having 8 to 24 carbon atoms in the alkenyl group with alcohols such as the polyglycols.", "Also useful are the aminosuccinic acids or derivatives.", "Preferably a dialkyl ester of an aminosuccinic acid is used containing an alkyl group containing 15-20 carbon atoms or an acyl group which is derived from a saturated or unsaturated carboxylic acid containing 2-10 carbon atoms.", "Most preferred is a dialkylester of an aminosuccinic acid.", "The various additives that can be included in the base greases of preferred embodiments are used in conventional amounts as are known in the grease industry.", "The amounts used in any particular case are preferably sufficient to provide the desired functional property to the grease composition, and such amounts are well known to those skilled in the art.", "Repellent Formulations The repellent formulations of preferred embodiments typically include a carrier agent, an activator agent, a repellent, a thickener, and a tackifying agent, as described above.", "In some embodiments, the activator agent, the carrier agent, and/or the tackifying agent may be omitted from the composition.", "Preferably, the repellent formulation utilizes a white oil.", "White oils include any of various highly refined, colorless mineral or hydrocarbon oils of low volatility and a wide range of viscosities.", "They are typically used for lubrication of food and textile machinery and as medicinal and mineral oils.", "White oils include technical white oils such as USP or Technical Grade white oil, and can be used as a carrier agent/base oil in formulations of preferred embodiments.", "In such embodiments, the white oil is typically present at from about 78.0 to 88.0 wt.", "% in the formulation, and more desirably at about 83.9 wt.", "%.", "In other embodiments, white oil is desirably present at about 82.9 wt.", "% in the formulation.", "The repellent formulation preferably utilizes fumed silica, such as AEROSIL 972™ manufactured by Degussa Corporation of Orange, Calif. or CABOSIL TS720™ manufactured by Cabot Corporation of Boston, Mass.", "When using AEROSIL 972™, it is preferably present in the repellent formulation at from about 5.0 to 12.0 wt.", "%, and more desirably at about 10.0 wt.", "%.", "When using CABOSIL TS720™, it is preferably present in the repellent formulation at from about 5.0 to 12.0 wt.", "%, and more desirably at about 10.0 wt.", "%.", "The repellent composition preferably includes one or more tackifying polymers, preferably an olefin copolymer, polybutene, polyalphaolefin, or polymethacrylate of suitable viscosity.", "The tackifying agent is preferably present in the formulation in total at from 5.0 to 10.0 wt.", "%, and more desirably at about 5.0 wt.", "%.", "The repellent composition preferably includes an activator agent such as denatured ethanol.", "When using denatured ethanol, it is preferably present in the formulation in total at from 1.0 to 2.0 wt.", "%, and more desirably at about 1.0 part by weight.", "The repellent additive in the repellent composition is preferably natural capsaicin.", "When using natural capsaicin, it is preferably present in the formulation in total at from 0.025 to 1.00 wt.", "%, and more desirably at about 0.075 wt.", "%.", "Preferably, the repellent compositions of preferred embodiments contain no menthol, peppermint oil, citronella, or other components that repel insects and hoofed animals by emitting an odor that insects and hoofed animals find offensive.", "The repellent composition may preferably include one or more tackifying polymers, preferably an olefin copolymer, polybutene, polyalphaolefin, or polymethacrylate of suitable viscosity.", "In some embodiments, the repellent formulation utilizes two different tackifiers, preferably polyalphaolefin and an olefin copolymer.", "In such a preferred embodiment, the tackifiers are preferably present in the formulation in total at from about 0.05 wt.", "% to about 10.0 wt.", "%.", "More preferably polyalphaolefin is present in the formulation at about 5.0 wt.", "% and an olefin copolymer is present in the formulation at about 1.0 wt.", "%.", "In preferred embodiments where polyalphaolefin is present in the formulation at about 5.0 wt.", "% and an olefin copolymer is present in the formulation at about 1.0 wt.", "%, the white oil is preferably present at about 82.9 wt.", "%.", "EXAMPLES Although the repellent compositions of preferred embodiments can be made by various methods as will be appreciated by one of skill in the art, the following is an exemplary method for use in preparing a repellent composition of a preferred embodiment comprising technical grade white oil, denatured ethanol, fumed silica, tackifying polymer, and capsaicin.", "In a first step, the full amount of technical grade white oil is added to a mixer.", "In a next step, denatured ethanol and fumed silica are sequentially or concurrently added to the white oil while mixing.", "Next, the mixture is heated up to about 120° F. (49° C.).", "The mixture is maintained at this temperature while mixing until the fumed silica is completely or nearly completely dispersed and the mixture clear.", "Thereafter, the polymer tackifier is added while mixing and maintaining the mixture at about 120° F. (49° C.).", "Mixing at about 120° F. (49° C.) is continued until the polymer is completely or nearly completely dissolved and the mixed product is clear.", "Then, the capsaicin is completely mixed in, and the product is cooled down to about 120° F. (27° C.).", "The repellent composition thus prepared is stable at ambient temperatures in environments supporting insects and hoofed animals.", "The examples below list different exemplary formulations for the deterrent composition of preferred embodiments.", "In the examples below, the column “Component” lists exemplary ingredients for the composition, the column “Mass %” lists desirable parts by weight of the ingredients in the composition and the column “Range Mass %” lists exemplary parts by weight of the ingredients.", "The asterisk “*” indicates that the base oil component is added to bring the total mass % up to 100%, after the other ingredients are accounted for.", "Example 1 Component Mass % Range Mass % Technical Grade/USP White 82.925 78.0-88.0 Oil Denatured Ethanol 1.0 1.0-2.0 Capsaicin (Natural) 0.075 0.025-0.075 Aerosil 972 Fumed Silica 10.0 5.0-12.0 PAO 5.0 5.0-10.0 Olefin Copolymer/Tackifier 1.0 1.0-2.0 Example 2 Component Mass % Range Mass % Technical Grade/USP White 82.925* 78.0-88.0 Oil Denatured Ethanol 1.0 1.0-2.0 Capsaicin (Natural) 0.075 0.025-0.075 CabOSil TS-720 10.0 5.0-12.0 Olefin Copolymer/Tackifier 1.0 1.0-2.0 PAO 5.0 5.0-10.0 Example 3 Component Mass % Range Mass % Technical Grade/USP White 83.925* 78.0-88.0 Oil Denatured Ethanol 1.0 1.0-2.0 Capsaicin (Natural) 0.075 0.025-0.075 Aerosil 972 Fumed Silica 10.0 5.0-12.0 Polybutene 5.0 5.0-10.0 Example 4 Component Mass % Range Mass % Technical Grade/USP White 83.925* 78.0-88.0 Oil Denatured Ethanol 1.0 1.0-2.0 Capsaicin (Natural) 0.075 0.025-0.075 CabOSil TS-720 10.0 5.0-12.0 Polybutene 5.0 5.0-10.0 Example 5 Component Mass % Range Mass % Technical Grade/USP White 83.925* 78.0-88.0 Oil Denatured Ethanol 1.0 1.0-2.0 Capsaicin (Natural) 0.075 0.025-0.075 Aerosil 972 Fumed Silica 10.0 5.0-12.0 Ethylene/Propylene 5.0 5.0-10.0 Copolymer Example 6 Component Mass % Range Mass % Technical Grade/USP White 83.925* 78-88 Oil Denatured Ethanol 1.0 1.0-2.0 Capsaicin (Natural) 0.075 0.025-0.075 CabOSil TS-720 10.0 5.0-12.0 Ethylene/Propylene 5.0 5.0-10.0 Copolymer The repellent compositions of preferred compositions can be applied to surfaces using similar techniques to application of caulk.", "A line, bead, or strip of the repellent composition is applied to a surface in an area where insects are to be repelled.", "When an insect contacts the repellent composition, e.g., by stepping on it, the repellent composition is transferred to the insect's exoskeleton.", "When the insect attempts to remove the repellent composition, e.g., by eating it off, the repellent additive in the repellent composition produces an unpleasant taste, thereby discouraging the insect from contacting the repellent composition again (e.g., attempting to cross a strip of the repellent composition).", "The repellent compositions of preferred compositions can be applied to surfaces using similar techniques to application of caulk.", "A line, bead, or strip of the repellent composition is applied to a surface in an area where insects are desired to be repelled, or where hoofed animals exhibit undesirable behavior.", "When an insect contacts the repellent composition, e.g., by eating it, the repellent additive in the repellent composition produces an unpleasant taste, thereby discouraging the insect from contacting the repellent composition again.", "Similarly the repellent composition can prevent a hoofed animal from contacting the repellent composition again (e.g., using a treated area for cribbing).", "The repellent compositions of preferred embodiments can offer numerous advantages over conventional repellent compositions.", "The repellent compositions of preferred embodiments can be odor free or low odor, enabling them to be employed in areas such as restaurants, stores, and homes where odors would otherwise be offensive or unacceptable.", "The repellent compositions of preferred embodiments are non-toxic and environmentally friendly, making them acceptable for use near soil or water sources (rivers, streams, canals, water features, ground water, etc.", "), or areas inhabited by children, pets (e.g., dogs, cats) or non-pest native species (e.g., native birds, mammals, reptiles, amphibians, fish).", "The repellent compositions of preferred embodiments are tacky, enabling them to remain in place when applied to non-horizontal surfaces (e.g., slanting, vertical, or inverted), and to persist on insects' exoskeletons or hoofed animal when contacted, which increases the repellent effect when the insects and hoofed animals groom themselves to remove the repellent composition.", "The repellent compositions of preferred embodiments are also water resistant, such that they can remain in place and retain their repellency when exposed to the elements (rain, snow).", "The repellent compositions of preferred embodiments are stable and maintain good viscosity/tackiness when exposed to hot or cold ambient conditions.", "In further embodiments, the compositions described above can be used as an insect repellant and the methods described above can be used to repel insects.", "The repellant compositions can be any of the repellant compositions described above, including those containing capsaicin, piperine, allyl isothiocyanate, and/or allicin as a repellant additive.", "While one compositions containing one repellant additive can advantageously be employed, combinations of two or more additives, e.g., capsaicin and piperine, are also suitable for use.", "The compositions and methods described above are effective at repelling a large variety of insects, including fairly resilient insects such as cockroaches.", "The repellant additive can cause insects to be repelled from an area or exterminated in an area.", "In some embodiments, the insects are exterminated.", "The additive can exterminate insects through one or more of metabolic disruption, membrane damage, or nervous system dysfunction.", "Additionally, when formulated as an oil or grease, the composition can block the air holes (spiracles) through which insects breathe, causing them to die from asphyxiation.", "In some cases, oils also may act as poisons, interacting with the fatty acids of the insect and interfering with normal metabolism.", "Oils may also disrupt how the insect feeds.", "In further embodiments, the compositions described above can be used to deter undesirable behavior in hoofed animals.", "The repellant compositions can be any of the repellant compositions described above, including those containing capsaicin, piperine, allyl isothiocyanate, and/or allicin as a repellant additive.", "While one compositions containing one repellant additive can advantageously be employed, combinations of two or more additives, e.g., capsaicin and piperine, are also suitable for use.", "The undesirable behavior includes cribbing, wood-chewing, and removing bandages.", "Cribbing is a behavior in which a hoofed animal may place its mouth on a solid object, arch its neck, and suck in air.", "This behavior can cause many health problems including colic and stomach ulcers.", "The compositions described above can be spread over solid objects that a hoofed animal may be tempted to use for cribbing or wood-chewing.", "Additionally, the compositions described above can be spread over bandages that are placed on a hoofed animal to prevent the hoofed animal from attempting to remove the bandages.", "All references cited herein are incorporated herein by reference in their entirety.", "To the extent publications and patents or patent applications incorporated by reference contradict the disclosure contained in the specification, the specification is intended to supersede and/or take precedence over any such contradictory material.", "Unless otherwise defined, all terms (including technical and scientific terms) are to be given their ordinary and customary meaning to a person of ordinary skill in the art, and are not to be limited to a special or customized meaning unless expressly so defined herein.", "Terms and phrases used in this application, and variations thereof, especially in the appended claims, unless otherwise expressly stated, should be construed as open ended as opposed to limiting.", "As examples of the foregoing, the term ‘including’ should be read to mean ‘including, without limitation,’ ‘including but not limited to,’ or the like; the term ‘comprising’ as used herein is synonymous with ‘including,’ ‘containing,’ or ‘characterized by,’ and is inclusive or open-ended and does not exclude additional, unrecited elements or method steps; the term ‘having’ should be interpreted as ‘having at least;’ the term ‘includes’ should be interpreted as ‘includes but is not limited to;’ the term ‘example’ is used to provide exemplary instances of the item in discussion, not an exhaustive or limiting list thereof; adjectives such as ‘known’, ‘normal’, ‘standard’, and terms of similar meaning should not be construed as limiting the item described to a given time period or to an item available as of a given time, but instead should be read to encompass known, normal, or standard technologies that may be available or known now or at any time in the future; and use of terms like ‘preferably,’ ‘preferred,’ ‘desired,’ or ‘desirable,’ and words of similar meaning should not be understood as implying that certain features are critical, essential, or even important to the structure or function of the invention, but instead as merely intended to highlight alternative or additional features that may or may not be utilized in a particular embodiment of the invention.", "Likewise, a group of items linked with the conjunction ‘and’ should not be read as requiring that each and every one of those items be present in the grouping, but rather should be read as ‘and/or’ unless expressly stated otherwise.", "Similarly, a group of items linked with the conjunction ‘or’ should not be read as requiring mutual exclusivity among that group, but rather should be read as ‘and/or’ unless expressly stated otherwise.", "With respect to the use of substantially any plural and/or singular terms herein, those having skill in the art can translate from the plural to the singular and/or from the singular to the plural as is appropriate to the context and/or application.", "The various singular/plural permutations may be expressly set forth herein for sake of clarity.", "It will be further understood by those within the art that if a specific number of an introduced claim recitation is intended, such an intent will be explicitly recited in the claim, and in the absence of such recitation no such intent is present.", "For example, as an aid to understanding, the following appended claims may contain usage of the introductory phrases “at least one” and “one or more” to introduce claim recitations.", "However, the use of such phrases should not be construed to imply that the introduction of a claim recitation by the indefinite articles “a” or “an” limits any particular claim containing such introduced claim recitation to embodiments containing only one such recitation, even when the same claim includes the introductory phrases “one or more” or “at least one” and indefinite articles such as “a” or “an” (e.g., “a” and/or “an” should typically be interpreted to mean “at least one” or “one or more”); the same holds true for the use of definite articles used to introduce claim recitations.", "In addition, even if a specific number of an introduced claim recitation is explicitly recited, those skilled in the art will recognize that such recitation should typically be interpreted to mean at least the recited number (e.g., the bare recitation of “two recitations,” without other modifiers, typically means at least two recitations, or two or more recitations).", "Furthermore, in those instances where a convention analogous to “at least one of A, B, and C, etc.” is used, in general such a construction is intended in the sense one having skill in the art would understand the convention (e.g., “a system having at least one of A, B, and C” would include but not be limited to systems that have A alone, B alone, C alone, A and B together, A and C together, B and C together, and/or A, B, and C together, etc.).", "In those instances where a convention analogous to “at least one of A, B, or C, etc.” is used, in general such a construction is intended in the sense one having skill in the art would understand the convention (e.g., “a system having at least one of A, B, or C” would include but not be limited to systems that have A alone, B alone, C alone, A and B together, A and C together, B and C together, and/or A, B, and C together, etc.).", "It will be further understood by those within the art that virtually any disjunctive word and/or phrase presenting two or more alternative terms, whether in the description, claims, or drawings, should be understood to contemplate the possibilities of including one of the terms, either of the terms, or both terms.", "For example, the phrase “A or B” will be understood to include the possibilities of “A” or “B” or “A and B.” All numbers expressing quantities of ingredients, reaction conditions, and so forth used in the specification are to be understood as being modified in all instances by the term ‘about.’ Accordingly, unless indicated to the contrary, the numerical parameters set forth herein are approximations that may vary depending upon the desired properties sought to be obtained.", "At the very least, and not as an attempt to limit the application of the doctrine of equivalents to the scope of any claims in any application claiming priority to the present application, each numerical parameter should be construed in light of the number of significant digits and ordinary rounding approaches.", "Furthermore, although the foregoing has been described in some detail by way of illustrations and examples for purposes of clarity and understanding, it is apparent to those skilled in the art that certain changes and modifications may be practiced.", "Therefore, the description and examples should not be construed as limiting the scope of the invention to the specific embodiments and examples described herein, but rather to also cover all modification and alternatives coming with the true scope and spirit of the invention." ] ]
Patent_15875956
[ [ "DOCKING STATION FOR TABLET DEVICE", "A docking station for a tablet device includes a security frame that is releasably connected to a pedestal.", "An upper head portion of the pedestal is rotatable through three degrees of freedom to allow for angular adjustment of the frame as it retains a tablet device.", "Electrical conductivity is maintained through the rotational connection." ], [ "1.A docking station for a tablet device, comprising: a frame assembly for retaining the tablet device, the frame assembly substantially surrounding the tablet device and comprising a first adapter for electrically coupling the tablet device to at least the frame assembly, the first adapter being electrically coupleable to a variety of different types of tablet devices; and a pedestal assembly for releasably connecting the frame assembly to the pedestal assembly via a locking structure disposed on the pedestal assembly to allow the frame assembly to be removed from the pedestal assembly via an associated unlock feature, the pedestal assembly comprising a second adapter positioned to create a detachable connection point for electrically coupling the second adapter to the first adapter while the frame assembly is releasably connected to the pedestal assembly.", "2.The docking station of claim 1, wherein the unlock feature comprises an electronic unlock feature.", "3.The docking station of claim 2, wherein the electronic unlock feature comprises a wireless unlock feature.", "4.The docking station of claim 3, wherein the wireless unlock feature comprises a radio frequency identification (RFID) unlock feature.", "5.The docking station of claim 3, wherein the wireless unlock feature comprises a sensor operable to detect a wireless key.", "6.The docking station of claim 5, wherein the sensor comprises a radio frequency identification (RFID) sensor.", "7.The docking station of claim 5, wherein the sensor activates the locking structure upon detection of the wireless key to allow the frame assembly to be removed from the pedestal assembly.", "8.The docking station of claim 1, wherein the pedestal assembly comprises an electronics control board (ECB) coupleable to one or more electrical connector fittings for providing at least one of the following for the tablet device: power, networking, communication, or a combination thereof.", "9.The docking station of claim 8, wherein the one or more electrical connector fittings comprise one or more of the following: one or more universal serial bus (USB) connector fittings; one or more power connector fittings; one or more network connector fittings; or any combination thereof.", "10.The docking station of claim 1, wherein the pedestal assembly provides at least one electrical connection port for at least one electrical signal.", "11.A docking station for a tablet device, comprising: a frame assembly for retaining the tablet device, the frame assembly substantially surrounding the tablet device and comprising a first adapter having electrically interconnected fittings arranged at opposing sides of the frame assembly for electrically coupling the tablet device to at least the frame assembly, the first adapter being electrically coupleable to a variety of different types of tablet devices; and a pedestal assembly having a head portion for releasably connecting the frame assembly to the pedestal assembly via a locking structure disposed on the head portion to allow the frame assembly to be removed from the pedestal assembly via an associated unlock feature while retaining the tablet device within the frame assembly, the head portion comprising a second adapter positioned to create a detachable connection point at the head portion for electrically coupling the second adapter to the first adapter while the frame assembly is releasably connected to the head portion of the pedestal assembly.", "12.The docking station of claim 11, wherein the unlock feature comprises an electronic unlock feature.", "13.The docking station of claim 12, wherein the electronic unlock feature comprises a wireless unlock feature.", "14.The docking station of claim 13, wherein the wireless unlock feature comprises a radio frequency identification (RFID) unlock feature.", "15.The docking station of claim 13, wherein the wireless unlock feature comprises a sensor operable to detect a wireless key.", "16.The docking station of claim 15, wherein the sensor comprises a radio frequency identification (RFID) sensor.", "17.The docking station of claim 15, wherein the sensor activates the locking structure upon detection of the wireless key to allow the frame assembly to be removed from the pedestal assembly.", "18.The docking station of claim 11, wherein the pedestal assembly comprises an electronics control board (ECB) coupleable to one or more electrical connector fittings for providing at least one of the following for the tablet device: power, networking, communication, or a combination thereof.", "19.The docking station of claim 18, wherein the one or more electrical connector fittings comprise one or more of the following: one or more universal serial bus (USB) connector fittings; one or more power connector fittings; one or more network connector fittings; or any combination thereof.", "20.The docking station of claim 11, wherein the pedestal assembly provides at least one electrical connection port for at least one electrical signal.", "21.A docking station for a tablet device, comprising: a frame assembly for retaining the tablet device and having a framework for carrying the tablet device while retained within the frame assembly, the frame assembly substantially surrounding the tablet device and comprising a first adapter having a first connector fitting positioned at a front side of the frame assembly and a second connector fitting positioned at a back side of the frame assembly, one or more of the first and the second connector fittings being shaped to fit one or more types of tablet devices and capable of electrically coupling the tablet device to at least the frame assembly; and a pedestal assembly comprising a second adapter positioned on a face of a head portion of the pedestal assembly to create a detachable connection point for electrically coupling the second adapter to the first adapter while the frame assembly is releasably connected to the pedestal assembly, the pedestal assembly allowing for three axes of rotation of the frame assembly while releasably connected to the pedestal assembly via a locking structure, the locking structure being disposed between guiding members arranged on the face of the head portion so as to slidably guide the first adapter into the second adapter to create an electrical pathway extending through the frame assembly and the pedestal assembly for connecting the tablet device to at least one source of an electrical signal.", "22.The docking station of claim 21, wherein the framework comprises one or more carrying means arranged on the frame assembly for carrying the tablet device retained within the frame assembly while the frame assembly is removed from the pedestal assembly.", "23.The docking station of claim 21, wherein the rotation of the frame assembly is implemented via one or more portions of the pedestal assembly.", "24.The docking station of claim 21, wherein the locking structure comprises a sensor operable to detect a wireless key.", "25.The docking station of claim 24, wherein the sensor comprises a radio frequency identification (RFID) sensor.", "26.The docking station of claim 24, wherein the sensor activates the locking structure upon detection of the wireless key to allow the frame assembly to be removed from the pedestal assembly." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>In general terms, electronic tablet devices (or “tablets”) have evolved such that they are now performing many of the functions that were formerly performed by laptop or desktop computers.", "The processing capability of tablets now allow them to perform standard business functions.", "Because of their size and portability, one of the problems associated with the use of tablets in a business setting relates to physical security and/or theft of the device itself.", "The design disclosed here addresses these problems." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The following is a summary of the various improvements disclosed in this document.", "The disclosed design is a docking station that is primarily intended to be used in connection with tablet devices.", "Tablet devices are well-known electronic devices.", "They are sometimes called electronic tablets, tablet computers, or just “tablets.” The docking station disclosed here includes a security frame portion for retaining the tablet.", "The security frame portion surrounds the tablet and provides a framework for carrying the tablet from place-to-place while retained within the security frame.", "The frame portion carries or has a first universal adapter that electrically couples the tablet to the frame portion.", "The universal adapter is designed so that it may electrically couple to the different kinds of connection ports that relate to different brands of tablets.", "As a person skilled in the art would know, these connection ports provide a means for transmitting power and data to and from the tablet.", "The docking station also includes a pedestal, or pedestal portion, that normally rests on a workstation surface or the like.", "The pedestal has a connecting head portion that provides a means for releasably connecting the above-described frame portion to the pedestal portion.", "The head portion carries a second universal adapter for electrically coupling the head portion to the first universal adapter on the frame portion, previously described, when the frame portion is connected or “docked” to the pedestal portion.", "Another feature of the design involves a rotational connection between the head portion of the pedestal and a lower base portion of the pedestal.", "The rotational connection enables three degrees of angular orientation or adjustment of the head portion relative to the base portion.", "This, in turn, allows for adjustment of the view angle of the tablet when it is docked.", "The base portion is connectable to or provides electrical connection ports for at least one electrical signal, although preferably, it includes ports for numerous kinds of electrical connections that normally involve power and data.", "A conductor pathway is provided through the base member to the universal adapter carried by the head portion by crossing the rotational connection between the head portion and the base portion.", "This allows electrical connectivity to be maintained regardless of the angular portion of the frame (and tablet) relative to the pedestal.", "Another feature of the design involves locking the frame to the pedestal.", "While this may be accomplished in different ways, the design disclosed here includes an electronic lock for additional security The foregoing summary will become better understood upon review of the attached drawings which are to be taken in conjunction with the written description set forth below." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of and claims priority under 35 USC 120 to U.S. patent application Ser.", "No.", "15/667,436, filed Aug. 2, 2017, entitled “DOCKING STATION FOR TABLET DEVICE,” which is a continuation of U.S. patent application Ser.", "No.", "14/097,171, filed Dec. 4, 2013, now U.S. Pat.", "No.", "9,760,116, entitled “DOCKING STATION FOR TABLET DEVICE,” which claims priority under 35 USC 119 to U.S.", "Provisional Application Ser.", "No.", "61/733,842, filed Dec. 5, 2012, and entitled, “DOCKING STATION FOR TABLET DEVICE,” the entire content of each of which is incorporated herein by reference; this application is related to U.S. Patent Application Ser.", "No.", "xx/xxx,xxx, filed Jan. 19, 2018, with attorney docket number 270.P002C3, entitled “DOCKING STATION FOR TABLET DEVICE.” TECHNICAL FIELD The design disclosed below relates to a docking station for a tablet device.", "More particularly, the design relates to a docking station that allows the tablet device to be used as a work station, or alternatively, the tablet device can be undocked and used remotely from the work station position.", "BACKGROUND OF THE INVENTION In general terms, electronic tablet devices (or “tablets”) have evolved such that they are now performing many of the functions that were formerly performed by laptop or desktop computers.", "The processing capability of tablets now allow them to perform standard business functions.", "Because of their size and portability, one of the problems associated with the use of tablets in a business setting relates to physical security and/or theft of the device itself.", "The design disclosed here addresses these problems.", "SUMMARY OF THE INVENTION The following is a summary of the various improvements disclosed in this document.", "The disclosed design is a docking station that is primarily intended to be used in connection with tablet devices.", "Tablet devices are well-known electronic devices.", "They are sometimes called electronic tablets, tablet computers, or just “tablets.” The docking station disclosed here includes a security frame portion for retaining the tablet.", "The security frame portion surrounds the tablet and provides a framework for carrying the tablet from place-to-place while retained within the security frame.", "The frame portion carries or has a first universal adapter that electrically couples the tablet to the frame portion.", "The universal adapter is designed so that it may electrically couple to the different kinds of connection ports that relate to different brands of tablets.", "As a person skilled in the art would know, these connection ports provide a means for transmitting power and data to and from the tablet.", "The docking station also includes a pedestal, or pedestal portion, that normally rests on a workstation surface or the like.", "The pedestal has a connecting head portion that provides a means for releasably connecting the above-described frame portion to the pedestal portion.", "The head portion carries a second universal adapter for electrically coupling the head portion to the first universal adapter on the frame portion, previously described, when the frame portion is connected or “docked” to the pedestal portion.", "Another feature of the design involves a rotational connection between the head portion of the pedestal and a lower base portion of the pedestal.", "The rotational connection enables three degrees of angular orientation or adjustment of the head portion relative to the base portion.", "This, in turn, allows for adjustment of the view angle of the tablet when it is docked.", "The base portion is connectable to or provides electrical connection ports for at least one electrical signal, although preferably, it includes ports for numerous kinds of electrical connections that normally involve power and data.", "A conductor pathway is provided through the base member to the universal adapter carried by the head portion by crossing the rotational connection between the head portion and the base portion.", "This allows electrical connectivity to be maintained regardless of the angular portion of the frame (and tablet) relative to the pedestal.", "Another feature of the design involves locking the frame to the pedestal.", "While this may be accomplished in different ways, the design disclosed here includes an electronic lock for additional security The foregoing summary will become better understood upon review of the attached drawings which are to be taken in conjunction with the written description set forth below.", "BRIEF DESCRIPTION OF THE DRAWINGS In the drawings, like reference numerals and letters refer to like parts throughout the various views, and wherein: FIG.", "1 is a perspective view of a docking station constructed in accordance with the patent claims; FIG.", "2 is a top view of the docking station; FIG.", "3 is a side view of the docking station; FIG.", "4 is a perspective view of a security frame portion of the docking station that holds or retains a tablet; FIG.", "5 is a perspective view of a back-side part of the security frame portion illustrated in FIG.", "4; FIG.", "6 is a perspective view of an adapter portion of the security frame illustrated in FIG.", "4; FIG.", "7 is a perspective view of the back-side of the security frame portion illustrated in FIG.", "4; FIG.", "8 is a perspective view of a pedestal portion of the docking station illustrated in FIG.", "1; FIG.", "9 is an enlarged view of the head of the pedestal portion illustrated in FIG.", "8; FIG.", "10 is a view like FIG.", "9, but is taken from the back-side perspective of the pedestal portion; FIG.", "11 is a view of the lower portion of the pedestal portion illustrated in FIG.", "8, with a cover removed to reveal an electronics board; FIG.", "12 is a perspective view of the docking station, showing angular rotation of the tablet device; and FIG.", "13 is a top view of FIG.", "12 and shows different rotational positions of the tablet device.", "DETAILED DESCRIPTION Referring now to the drawings, and first to FIG.", "1, indicated generally at 10 is a docking station in accordance with the present disclosure.", "The docking station 10 includes a security frame portion, indicated generally at 12, and a pedestal portion, indicated generally at 14.The pedestal portion 14 surrounds and captures a tablet device 16.The outline of the tablet's screen is indicated by dashed line 18 in FIG.", "1.The activating button on the tablet is indicated at 20.Although the frame 12 is illustrated here as surrounding and capturing the tablet 16, it is to be understood that there could be other physical embodiments that perform the same function without completely surrounding the entire or full periphery of the tablet 16.Referring now to FIGS.", "4-7, further details of the frame portion 12 will now be described.", "FIG.", "4 illustrates the frame portion 12 without the tablet inside (looking at the front).", "As can be seen from the Fig., it has a rectangular peripheral edge 22 that captures the edge of the tablet 16.Depending on the configuration, the edge structure 22 may be provided with built-in openings for different kinds of tablet access ports (for the purpose of pushing buttons on the tablet or accessing jacks, etc.).", "The frame 12 carries a first electrical adapter, indicated generally at 24 in FIGS.", "4 and 6, that provides the needed electrical connection to the tablet 16.The adapter 24 is “universal” in that it has a universal connector fitting 26 that would be shaped to fit a variety of different kinds of tablets (tablet variations are dictated by brand).", "Typically, and as a person skilled in the art would understand, the universal adapter 24 provides power and data connections for the tablet—i.e., power for the device's battery, etc., and data for network or Internet connections, if hard-wired connections are desired.", "The conductors for the universal adapter 24 run through a stem portion 28 (see FIG.", "6 of the universal adapter 24).", "FIG.", "5 illustrates the back-side or back plate 30 of the frame portion 12.It is surrounded by the edge 22 previously described.", "As is shown in FIG.", "5, it has an opening 30 for capturing the universal adapter 24 previously described.", "When all of these components are assembled together, it produces the frame portion of the docking station indicated in FIG.", "4 (the front side) and FIG.", "7 (the back side).", "Referring now to FIG.", "8, reference numeral 14 generally indicates the pedestal portion of the docking station 10.The pedestal portion includes an upper head portion, indicated generally at 36, and a lower base portion, indicated generally at 38.The head portion 36 carries a second universal adapter 40 that connects into a similar connector fitting in a recess of 42 of the first adapter 24.The first adapter 24 releasably rests on protrusions 44, 46 on head portion 36.It has a conventional catch 48 that allows adapter 24 (and therefore, frame 12) to be releasably connected to and from the pedestal portion 14 (via the head 36).", "An advantage to the design is that the portion fitting 40 adjacent the front face 52 of head portion 36 creates a reliable interface connection point for engagement/disengagement of the first universal adapter 24 (and frame portion 12) with the pedestal portion 14.The head portion 36 is designed to rotate at three physical positions.", "The first position is indicated by arrow 50 in FIG.", "9, which illustrates a circular rotation of the front face 52 of the head portion about an axis that would project normally out from face 52.When the frame portion 12 is mounted to the pedestal 14, this arrangement provides one degree of freedom of rotation that would allow the tablet 16 to be rotated between portrait and landscape orientations, if desired.", "Arrow 54 in FIG.", "10 points to another area designed to allow the head 36 to rotate up or down to rotationally lift or lower the screen of the tablet for vertical positioning, as desired.", "Finally, arrow 56 points to a last position for angularly rotating the head about a vertical or upright axis for angularly adjusting the tablet screen 16 from left-to-right, as desired.", "The physical structure of the above rotational connections can take different forms, using different types of pins or moldings that allow one part to rotate relative to another.", "In all cases, what is important about the design is that it allows three degrees of rotation without interfering with the wiring in the pedestal portion.", "FIGS.", "12 and 13 illustrate different possible rotational positions.", "In this last respect, FIG.", "11 illustrates base portion 38 with its cover plate 60 removed, thus exposing an electronics control board (ECB) 58 inside the base portion.", "A series of electrical connector fittings (USB, etc.)", "are electrically connected to the ECB 58 for providing data or power.", "These electrical signals are passed, via wiring, or a wiring harness, up through the body of the pedestal 14, which is hollow.", "The position of the wiring is schematically indicated by dashed line 63 in FIG.", "8.Referring to FIG.", "10, the pedestal 14 has openings 64, 66 that enable the wiring to pass through the head space, and through the physical zone of rotational connections described above.", "This allows rotation without stressing the wiring.", "The wiring connects to a board 67 upon which the second adapter fitting 40 rests.", "The board 67 provides the wiring connections to the fitting 40.Finally, the frame portion 12 could be releasably locked to the pedestal portion via a RFID lock if desired.", "The ECB 58 in the base portion has surface space for a RFID sensor 70 that could detect a wireless keycard, if desired.", "The sensor would activate locks on the head portion, upon detection of the keycard.", "It is to be appreciated that the foregoing description sets forth the best known examples and embodiments.", "It is not intended that any of the foregoing description be used to limit the scope of the patent protection.", "Instead, all patent protection is to be defined solely by the patent claim or claims that follow this description, the interpretation of which is to be made according to the legal rules of patent claim interpretation and the rules and regulations of the U.S. Patent and Trademark Office." ] ]
Patent_15875957
[ [ "METHODS AND APPARATUS TO COOL A VEHICLE HEAT SOURCE", "Methods and apparatus to cool a vehicle heat source are disclosed herein.", "An example apparatus includes a first tank and a second tank.", "The first tank and the second tank are disposed on a vehicle.", "The second tank is in fluid communication with the first tank.", "An engine of the vehicle is to be supplied with fuel from at least one of the first tank or the second tank.", "The example apparatus also includes a cooling system disposed on the vehicle to cool the fuel flowing from the first tank to the second tank.", "The example apparatus further includes a heat exchanger operatively coupled to a heat source disposed on the vehicle.", "The fuel from the second tank is to flow to the first tank via the heat exchanger to cool the heat source." ], [ "1.An apparatus comprising: a first tank disposed on a vehicle; a second tank disposed on the vehicle, the second tank in fluid communication with the first tank, an engine of the vehicle to be supplied with fuel from at least one of the first tank or the second tank; a cooling system disposed on the vehicle to cool fuel flowing from the first tank to the second tank; and a heat exchanger operatively coupled to a heat source disposed on the vehicle, fuel from the second tank to flow to the first tank via the heat exchanger to cool the heat source.", "2.The apparatus of claim 1, further including a first pump and a second pump, the first pump to pump fuel from the first tank toward the second tank at a first flow rate, the second pump to pump fuel from the second tank toward the first tank at a second flow rate greater than the first flow rate.", "3.The apparatus of claim 1, wherein the heat source includes a component of a weapon system.", "4.The apparatus of claim 1, wherein the vehicle is an aircraft.", "5.The apparatus of claim 1, wherein the cooling system includes an evaporator.", "6.The apparatus of claim 1, further including a bypass disposed between the cooling system and the second tank, the bypass to direct cooled fuel into at least one of the second tank or the heat exchanger.", "7.An apparatus comprising: a fuel feed system that includes a feed tank to provide fuel to an engine of an aircraft; and a heat source management system including a first tank to store fuel at a first temperature and a second tank to store cooled fuel at a second temperature less than the first temperature, the heat source management system including a cooling system interposed in a first fuel line between the first tank and the second tank, the heat source management system to cool a heat source of the aircraft via the cooled fuel.", "8.The apparatus of claim 7, wherein the heat source management system is to cool the heat source based on an operating temperature of the heat source.", "9.The apparatus of claim 8, wherein, in response to a determination that the operating temperature is greater than a heat source threshold temperature, the heat source management system is to cause fuel from the second tank having the second temperature to flow to a heat exchanger positioned between the second tank and the first tank to cool the heat source via a second fuel line fluidly coupling the second tank to an inlet of the heat exchanger and an outlet of the heat exchanger to the first tank.", "10.The apparatus of claim 8, wherein the heat source management system is to provide cooled fuel from the second tank to the feed tank prior to flowing fuel in the first tank to the feed tank in response to the operating temperature of the heat source being less than a heat source threshold temperature.", "11.The apparatus of claim 7, wherein the heat source management system is to determine an operational status of the heat source, the operational status including at least one of a pre-operational mode, a standby mode, or an operational mode.", "12.The apparatus of claim 11, wherein in response to the heat source being in the pre-operational mode, the heat source management system is to cause fuel from the second tank to flow to the engine prior to flowing fuel in the first tank to the engine.", "13.The apparatus of claim 11, wherein in response to the operational status of the heat source being in at least one of a standby mode or an operational mode, the heat source management system is to cause fuel from the second tank to flow into a heat exchanger to cool the heat source disposed on the aircraft, the heat exchanger being interposed in a second fuel line that is coupled to the second tank and the first tank.", "14.The apparatus of claim 7, wherein the heat source management system is to substantially empty fuel in the second tank to operate the engine prior to emptying fuel in the first tank.", "15.The apparatus of claim 7, wherein the heat source management system is to fill a portion of the second tank with the fuel from the first tank when the second tank has an amount of fuel less than a volume threshold.", "16.An apparatus comprising: a first tank disposed on a vehicle, the first tank to hold fuel having a first temperature; a second tank disposed on the vehicle, the second tank to hold fuel having a second temperature less than the first temperature, an engine of the vehicle to be supplied with fuel from at least one of the first tank or the second tank; a first fuel line to fluidly couple the first tank and the second tank; a cooling system located between the first tank and the second tank to cool fuel flowing from the first tank to the second tank, the cooling system being interposed in the first fuel line such that the first fuel line is to fluidly couple the first tank and an inlet of the cooling system and the first fuel line is to fluidly couple an outlet of the cooling system to the second tank, the cooling system to cool the fuel flowing from the first tank to a predetermined temperature prior to the fuel entering the second tank; a second fuel line fluidly coupling to the second tank and the first tank; a heat exchanger operatively coupled to a heat source disposed on the vehicle, fuel from the second tank to flow to the first tank via the heat exchanger to cool the heat source, the heat exchanger being interposed in the second fuel line such that the second fuel line fluidly couples the second tank to an inlet of the heat exchanger and the second fuel line fluidly couples an outlet of the heat exchanger to the first tank; a first bypass disposed between the cooling system and the second tank, the first bypass to direct cooled fuel into at least one of the second tank or the heat exchanger; a second bypass disposed between the second tank and the heat exchanger, the second bypass to direct cooled fuel into at least one of a first feed tank or a second feed tank; and a third bypass disposed between the first tank and the cooling system, the third bypass to direct fuel from the first tank into at least one of the first feed tank or the second feed tank.", "17.The apparatus of claim 16, further including a first pump and a second pump, the first pump to pump the fuel from the first tank toward the second tank at a first flow rate, the second pump to pump the fuel from the second tank toward the first tank at a second flow rate greater than the first flow rate.", "18.The apparatus of claim 16, wherein fuel from the second tank is used to supply the engine of the vehicle prior to using fuel from the first tank.", "19.The apparatus of claim 16, further including a heat source management system to direct cooled fuel from at least one of the second tank to the heat source or the cooling system via the first bypass when an operational temperature of the heat source is greater than a threshold temperature.", "20.The apparatus of claim 16, further including a heat source management system to determine if the heat source is in a pre-operational mode, an operational mode or a standby mode, the heat source management system to: (1) provide cooled fuel to the heat source in response to detecting that the heat source is in the operational mode if a volume of cooled fuel in the second tank is greater than a volume threshold; (2) supply the cooled fuel from the second tank to the engine in response to detecting that the heat source is in the pre-operational mode and the volume of the cooled fuel in the second tank is greater than the volume threshold; or (3) supply fuel from the first tank to the second tank in response to detecting that the heat source is in the standby mode and the second tank is not substantially full or stop fuel flow to the second tank from the first tank when the second tank is substantially full." ], [ "<SOH> BACKGROUND <EOH>Generally, during operation of an aircraft engine, fuel flows from a tank to the aircraft engine.", "As the fuel flows from the tank to the aircraft engine, a large quantity of the fuel may be used as a heat sink to cool a fluid employed to operate the aircraft engine and/or other equipment on an aircraft.", "For example, the fuel may pass through a fuel-to-oil heat exchanger between the tank and the engine to cool oil lubricating the aircraft engine.", "Generally, a temperature of the fuel stored in the tank is increased by operating conditions of the aircraft such as, for example, a temperature of an environment in which the aircraft is disposed and/or heat generated by the aircraft.", "Such an increase in fuel temperature may be undesirable for various reasons." ], [ "<SOH> SUMMARY <EOH>An example apparatus disclosed herein includes a first tank and a second tank.", "The first tank and the second tank are disposed on a vehicle.", "The second tank is in fluid communication with the first tank.", "An engine of the vehicle is to be supplied with fuel from the first tank or the second tank.", "The example apparatus also includes a cooling system disposed on the vehicle to cool the fuel flowing from the first tank to the second tank.", "The example apparatus further includes a heat exchanger operatively coupled to a heat source disposed on the vehicle.", "The fuel from the second tank is to flow to the first tank via the heat exchanger to cool the heat source.", "An example apparatus disclosed herein includes a fuel feed system that includes a feed tank to provide fuel to an engine of an aircraft.", "The apparatus includes a heat source management system including a first tank to store fuel at a first temperature and a second tank to store cooled fuel at a second temperature less than the first temperature, the heat source management system including a cooling system interposed in a first fuel line between the first tank and the second tank, the heat source management system to cool a heat source of the aircraft via cooled fuel.", "Another example apparatus disclosed herein includes a first tank disposed on a vehicle, the first tank to hold fuel having a first temperature.", "A second tank is disposed on the vehicle.", "The second tank is to hold fuel having a second temperature less than the first temperature.", "An engine of the vehicle to be supplied with fuel from at least one of the first tank or the second tank.", "A first fuel line is to fluidly couple the first tank and the second tank.", "A cooling system is located between the first tank and the second tank to cool fuel flowing from the first tank to the second tank.", "The cooling system being interposed in the first fuel line such that the first fuel line is to fluidly couple the first tank and an inlet of the cooling system and the first fuel line is to fluidly couple an outlet of the cooling system to the second tank.", "The cooling system to cool the fuel flowing from the first tank to a predetermined temperature prior to the fuel entering the second tank.", "A second fuel line fluidly coupling to the second tank and the first tank.", "A heat exchanger is operatively coupled to a heat source disposed on the vehicle, fuel from the second tank to flow to the first tank via the heat exchanger to cool the heat source, the heat exchanger being interposed in the second fuel line such that the second fuel line fluidly couples the second tank to an inlet of the heat exchanger and the second fuel line fluidly couples an outlet of the heat exchanger to the first tank.", "A first bypass is disposed between the cooling system and the second tank, the first bypass to direct cooled fuel into at least one of the second tank or the heat exchanger.", "A second bypass disposed between the second tank and the heat exchanger, the second bypass to direct cooled fuel into at least one of a first feed tank or a second feed tank.", "A third bypass is disposed between the first tank and the cooling system, the third bypass to direct fuel from the first tank into at least one of the first feed tank or the second feed tank.", "The features, functions and advantages that have been discussed can be achieved independently in various examples or may be combined in yet other examples further details of which can be seen with reference to the following description and drawings." ], [ "RELATED APPLICATION This patent arises from a divisional of U.S. patent application Ser.", "No.", "13/922,960, filed on Jun.", "20, 2013.U.S.", "patent application Ser.", "No.", "13/922,960 is hereby incorporated herein by reference in its entirety.", "STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This disclosure was made with Government support under Contract No.", "FA8650-11-2-2138 awarded by the United States Air Force/Air Force Materiel Command.", "The Government of the United States may have certain rights in this disclosure.", "FIELD This disclosure relates generally to vehicle heat sources and, more particularly, to methods and apparatus to cool a vehicle heat source.", "BACKGROUND Generally, during operation of an aircraft engine, fuel flows from a tank to the aircraft engine.", "As the fuel flows from the tank to the aircraft engine, a large quantity of the fuel may be used as a heat sink to cool a fluid employed to operate the aircraft engine and/or other equipment on an aircraft.", "For example, the fuel may pass through a fuel-to-oil heat exchanger between the tank and the engine to cool oil lubricating the aircraft engine.", "Generally, a temperature of the fuel stored in the tank is increased by operating conditions of the aircraft such as, for example, a temperature of an environment in which the aircraft is disposed and/or heat generated by the aircraft.", "Such an increase in fuel temperature may be undesirable for various reasons.", "SUMMARY An example apparatus disclosed herein includes a first tank and a second tank.", "The first tank and the second tank are disposed on a vehicle.", "The second tank is in fluid communication with the first tank.", "An engine of the vehicle is to be supplied with fuel from the first tank or the second tank.", "The example apparatus also includes a cooling system disposed on the vehicle to cool the fuel flowing from the first tank to the second tank.", "The example apparatus further includes a heat exchanger operatively coupled to a heat source disposed on the vehicle.", "The fuel from the second tank is to flow to the first tank via the heat exchanger to cool the heat source.", "An example apparatus disclosed herein includes a fuel feed system that includes a feed tank to provide fuel to an engine of an aircraft.", "The apparatus includes a heat source management system including a first tank to store fuel at a first temperature and a second tank to store cooled fuel at a second temperature less than the first temperature, the heat source management system including a cooling system interposed in a first fuel line between the first tank and the second tank, the heat source management system to cool a heat source of the aircraft via cooled fuel.", "Another example apparatus disclosed herein includes a first tank disposed on a vehicle, the first tank to hold fuel having a first temperature.", "A second tank is disposed on the vehicle.", "The second tank is to hold fuel having a second temperature less than the first temperature.", "An engine of the vehicle to be supplied with fuel from at least one of the first tank or the second tank.", "A first fuel line is to fluidly couple the first tank and the second tank.", "A cooling system is located between the first tank and the second tank to cool fuel flowing from the first tank to the second tank.", "The cooling system being interposed in the first fuel line such that the first fuel line is to fluidly couple the first tank and an inlet of the cooling system and the first fuel line is to fluidly couple an outlet of the cooling system to the second tank.", "The cooling system to cool the fuel flowing from the first tank to a predetermined temperature prior to the fuel entering the second tank.", "A second fuel line fluidly coupling to the second tank and the first tank.", "A heat exchanger is operatively coupled to a heat source disposed on the vehicle, fuel from the second tank to flow to the first tank via the heat exchanger to cool the heat source, the heat exchanger being interposed in the second fuel line such that the second fuel line fluidly couples the second tank to an inlet of the heat exchanger and the second fuel line fluidly couples an outlet of the heat exchanger to the first tank.", "A first bypass is disposed between the cooling system and the second tank, the first bypass to direct cooled fuel into at least one of the second tank or the heat exchanger.", "A second bypass disposed between the second tank and the heat exchanger, the second bypass to direct cooled fuel into at least one of a first feed tank or a second feed tank.", "A third bypass is disposed between the first tank and the cooling system, the third bypass to direct fuel from the first tank into at least one of the first feed tank or the second feed tank.", "The features, functions and advantages that have been discussed can be achieved independently in various examples or may be combined in yet other examples further details of which can be seen with reference to the following description and drawings.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates an example aircraft in which aspects of the present disclosure may be implemented.", "FIG.", "2 illustrates an example fuel system of the aircraft of FIG.", "1.FIG.", "3 illustrates an example heat source thermal management system of the example aircraft of FIG.", "1.FIG.", "4 is a block diagram representative of the example heat source thermal management system of FIG.", "3 including an example fuel flow controller disclosed herein.", "FIG.", "5 is a flowchart representative of an example method to cool a vehicle heat source.", "FIG.", "6 is a flowchart representative of another example method to cool a vehicle heat source.", "FIG.", "7 is a continuation of the flowchart of FIG.", "6, according to another example method to cool a vehicle heat source.", "FIG.", "8 is a flowchart representative of another example method disclosed herein.", "FIG.", "9 is a continuation of the flowchart of FIG.", "8.FIG.", "10 is a block diagram of an example processor platform capable of executing the methods to implement the flow controller and thermal management system of FIGS.", "3-4.The figures are not to scale.", "Instead, to clarify multiple layers and regions, the thickness of the layers may be enlarged in the drawings.", "Wherever possible, the same reference numbers will be used throughout the drawing(s) and accompanying written description to refer to the same or like parts.", "As used in this patent, stating that any part (e.g., a layer, film, area, or plate) is in any way positioned on (e.g., positioned on, located on, disposed on, or formed on, etc.)", "another part, means that the referenced part is either in contact with the other part, or that the referenced part is above the other part with one or more intermediate part(s) located therebetween.", "Stating that any part is in contact with another part means that there is no intermediate part between the two parts.", "DETAILED DESCRIPTION Methods and apparatus to cool a vehicle heat source are disclosed herein.", "In some examples, fuel stored in a vehicle is cooled from a first temperature to a second temperature, and fuel at or near the second temperature is used to cool a heat source such as, for example, a component of a weapon system disposed on the vehicle.", "In some examples, the fuel is circulated between two tanks disposed on the vehicle to cool the heat source.", "For example, the fuel may be cooled from the first temperature to the second temperature while the fuel is pumped from a first tank to a second tank via a fuel cooling system such as, for example, an evaporator.", "The fuel at the second temperature may be stored in the second tank, and fuel at the first temperature may be stored in the first tank.", "In some examples, the fuel in the first tank and/or the second tank supplies one or more engines of the vehicle with fuel.", "To remove heat generated during operation of the heat source, fuel at the second temperature is pumped from the second tank to a heat source cooling system operatively coupled to the heat source.", "The fuel then flows through the heat source cooling system and returns to the first tank.", "The heat source cooling system may include one or more heat exchangers, and the fuel may function as a heat sink to remove heat from or cool the heat source.", "In some examples, the cold tank is replenished with fuel at the second temperature by pumping fuel from the first tank to the second tank via the fuel cooling system.", "In this manner, the fuel may be repeatedly or substantially continuously cooled and circulated between the first tank and the second tank to cool the heat source.", "In some examples, a power of the heat source is larger than a capacity of a fuel cooling system, and the heat source operates on a limited duty cycle.", "For example, the power of the heat source may be ten times greater than the capacity of the fuel cooling system, and the heat source may operate on a 10 percent duty cycle such as, for example, 1 min heat source operation per 10 minutes of vehicle operation.", "To enable the heat source to transfer a sufficient amount of heat energy to the fuel without sizing the fuel cooling system for a peak heat load of the heat source, a given amount of the fuel that enables the sufficient amount of heat energy to be transferred to the fuel is cooled to a second temperature via the fuel cooling system and stored in the second tank prior to the operation of the heat source.", "As a result, the fuel stored in the second tank provides a thermal energy storage medium.", "In some examples, the fuel cooling system cools the given amount of the fuel over a period of time by transferring or flowing the fuel from the first tank to the second tank through the fuel cooling system.", "The period of time may be determined based on a desired capacity of the fuel cooling system relative to the power of the heat source that, for example, enables reduced energy consumption and/or maximizes range of the vehicle while enabling a predetermined operational capability.", "For example, the capacity of the fuel cooling system may reduce energy consumption by reducing a weight and/or a peak power of the fuel cooling system.", "FIG.", "1 illustrates an example aircraft 100 in which aspects of the present disclosure may be implemented.", "In the illustrated example, the aircraft 100 includes a fuselage 102, a first wing 104 and a second wing 106.A first engine 108 and a second engine 110 are disposed in the fuselage 102 aft of a canopy 112.The example aircraft of FIG.", "1 is a fixed-wing aircraft for military applications.", "However, the example aircraft 100 of FIG.", "1 is merely an example and, thus, the example methods and apparatus to cool a vehicle heat source disclosed herein may be implemented on other types of aircraft such as, for example, helicopters, passenger planes, etc.", "The example methods and apparatus may also be implemented on marine based vehicles and/or land based vehicles such as, for example, ships, tanks and/or any other vehicle.", "FIG.", "2 is a schematic illustrating an example fuel system 200 of the example aircraft 100 of FIG.", "1.The example aircraft 100 of FIG.", "1 utilizes fuel stored in the fuel system 200 to cool a heat source 302 (FIG.", "3) disposed on the aircraft 100.More specifically, the example aircraft 100 includes a heat source thermal management system 300 (FIG.", "3) to cool the fuel from a first temperature to a second temperature less than the first temperature, and the fuel at or near the second temperature (“cooled fuel”) is used to cool the heat source 302.In the illustrated example, two fuel tanks 202 and 204 are employed in the heat source thermal management system 300.The first tank 202 holds fluid having a temperature at or near the first temperature and, thus, is referred herein as “hot” tank 202.The second tank 204 holds fuel having a temperature at or near the second temperature and, thus, is referred herein as “cold” tank 204.In other examples, one or more additional and/or different fuel tanks may be employed in the heat source thermal management system 300.In the illustrated example, the hot tank 202 is disposed on a right side 206 of the aircraft 100 adjacent a longitudinal axis 208 of the aircraft 100.The cold tank 204 may be disposed on a left side 210 of the aircraft 100 adjacent the longitudinal axis 208 of the aircraft 100 and the hot tank 202.In some examples, the cold tank 204 and/or the hot tank 202 are disposed adjacent and/or above a payload or weapons bay.", "In the illustrated example, the hot tank 202 and the cold tank 204 have substantially equal fuel volume capacities to facilitate a balanced left-to-right weight distribution of the example aircraft 100.For example, the hot tank 202 and the cold tank 204 may each hold about 2,600 pounds of fuel.", "In other examples, the hot tank 202 and the cold tank 204 have different fuel volumes and/or are disposed in different locations.", "For example, the cold tank 204 may have a greater fuel capacity or a smaller fuel capacity than the hot tank 202.The cold tank 204 includes thermal insulation 212 to reduce and/or minimize an amount of heat transferred into the fuel stored in the cold tank 204.In some examples, the thermal insulation 212 substantially maintains the fuel in the cold tank 204 at or near the second temperature.", "The thermal insulation 212 may include aerogel insulation, Boeing Rigid Insulation (BRI) and/or any other suitable thermal insulation.", "The thermal insulation 212 may be disposed inside the cold tank 204 and/or substantially surround the cold tank 204.In some examples, the thermal insulation 212 defines a space inside the cold tank 204 to hold the fuel.", "In the illustrated example, the fuel system 200 may include thirteen fuel tanks 202, 204, 214, 216, 218, 220, 222, 224, 226, 228, 230, 232 and 234.The example fuel tanks 202, 204, 214, 216, 218, 220, 222, 224, 226, 228, 230, 232 and 234 may be arranged on the example aircraft 100 substantially symmetrically relative to the longitudinal axis 208 of the aircraft 100.In the illustrated example, six of the fuel tanks 202, 216, 218, 220, 222, and 224 may be disposed on the right side 206 of the example aircraft 100, and six of the fuel tanks 204, 226, 228, 230, 232 and 234 are disposed on the left side 210 of the example aircraft 100.The fuel tank 214 may be disposed on the right side 206 and the left side 210 of the example aircraft 100 and along the longitudinal axis 208.In some examples, when the fuel tanks 202, 204, 214, 216, 218, 220, 222, 224, 226, 228, 230, 232 and 234 are substantially filled with fuel, an amount of fuel on the left side 210 of the aircraft 100 may be substantially the same as an amount of fuel on the right side 206 of the aircraft 100.Thus, the example arrangement of the fuel tanks 202, 204, 214, 216, 218, 220, 222, 224, 226, 228, 230, 232 and 234 on the aircraft 100 may facilitate a left-to-right weight balance of the aircraft 100.In other examples, the fuel tanks 202, 204, 214, 216, 218, 220, 222, 224, 226, 228, 230, 232 and 234 are sized and/or arranged on the aircraft 100 to facilitate other weight distributions.", "Some or all of the example fuel tanks 202, 204, 214, 216, 218, 220, 222, 224, 226, 228, 230, 232 and 234 may be compartments defined by a frame, skin, one or more keels or ribs and/or other structural component(s) of the aircraft 100.In some examples, one or more of the fuel tanks 202, 204, 214, 216, 218, 220, 222, 224, 226, 228, 230, 232 and 234 are containers that are coupled to the example aircraft 100.For example, one or more of the fuel tanks 202, 204, 214, 216, 218, 220, 222, 224, 226, 228, 230, 232 and 234 may be suspended from one of the wings 104 and 106, disposed in a payload or weapon bay, etc.", "The above-noted fuel system 200 is merely one example.", "Thus, other example vehicles used to implement the examples disclosed herein employ different fuel systems having, for example, a different arrangement of fuel tanks, other numbers (e.g., 1, 2, 3, 4, 5, 6, etc.)", "of fuel tanks, fuel tanks disposed at different locations in and/or on the vehicle, etc.", "In some examples, the first engine 108 may be supplied with fuel from one or more of the fuel tanks 204, 226, 228, 230, 232 and 234 on the left side 210 of the aircraft 100 and/or the fuel tank 214 to control or manage a center of gravity of the aircraft 100.Similarly, the second engine 110 may be supplied with fuel from the one or more of the fuel tanks 202, 216, 218, 220, 222, and 224 on the right side 206 of the aircraft 100 and/or the fuel tank 214 to control or manage the center of gravity of the aircraft 100.In the illustrated example, the tank 230 may receive fuel from one or more of fuel tanks 204, 226, 228, 230, 232 and 234 on the left side 210 of the aircraft 100 and/or the tank 214 and direct the fuel to the first engine 108.Thus, the tank 230 is referred herein as first feed tank 230.The tank 220 may receive fuel from one or more of fuel tanks 202, 204, 216, 218, 220, 222, and 224 on the right side 206 of the aircraft 100 and/or the tank 214 and direct the fuel to the second engine 110.Thus, the tank 220 is referred to herein as second feed tank 220.FIG.", "3 is a schematic of the example heat source thermal management system 300 disclosed herein.", "The heat source 302 may be one or more components of a radar system, an electrical power system, a weapon system such as, for example, a direct energy weapon and/or any other heat source disposed on the example aircraft 100.The heat source 302 may generate heat substantially continuously or periodically.", "In some examples, the heat source 302 generates heat when the heat source 302 is selectively operated.", "For example, the weapon system or a radar system may generate heat when activated.", "In some examples, an amount of heat generated by the heat source 302 fluctuates during operation of the aircraft 100.For example, the heat source 302 may generate varying amounts of heat over a given period of time.", "In some examples, to enable proper operation of the heat source 302, a temperature of the heat source 302 is kept below a threshold temperature and/or within a given temperature range (an “operational temperature range”) such as, for example, approximately 68 degrees Fahrenheit to approximately 77 degrees Fahrenheit, or approximately 20 degrees Celsius to approximately 25 degrees Celsius.", "In the illustrated example, the hot tank 202 is in fluid communication with the cold tank 204 via a first fuel path 304 and a second fuel path 306.A fuel cooling system 308 is disposed along the first fuel path 304 between the hot tank 202 and the cold tank 204.The example fuel cooling system 308 includes at least one heat exchanger such as, for example, an air-to-fuel heat exchanger (e.g., a Ram air heat exchanger), a refrigerant-to-fuel heat exchanger (e.g., employing R-134 refrigerant), a water-to-fuel heat exchanger, one or more evaporators and/or any other suitable heat exchanger(s).", "The example fuel cooling system 308 cools the fuel from the first temperature to the second temperature as the fuel flows from the hot tank 202 to the cold tank 204 along the first fuel path 304.In the illustrated example, the hot tank 202 includes a first pump 310 to flow fuel stored in the hot tank 202 through the fuel cooling system 308 and into the cold tank 204.In the illustrated example, a heat source cooling system 312 is disposed along the second fuel path 306.In the illustrated example, the heat source cooling system 312 is operatively coupled to the heat source 302 to transfer heat from the heat source 302 to the fuel, thereby cooling the heat source 302 as the fuel passes along the second fuel path 306.The example heat source cooling system 312 may lower a temperature of the heat source 302 and/or enable the heat source 302 to be maintained in the operational temperature range.", "In some examples, the heat source cooling system 312 includes one or more cooling loops 314.The cooling loop(s) 314 may include one or more heat exchangers, pumps, valves and/or other suitable components to cool the heat source 302 via the fuel.", "In the illustrated example, the cooled fuel is utilized by the heat source cooling system 312 to cool the heat source 302.In some examples, the cooled fuel stored in the cold tank 204 is flowed from the cold tank 204 to the heat source cooling system 312 to cool the heat source 302 to level load a heat load generated by the heat source 302.In the illustrated example, the cold tank 204 includes a second pump 316 to flow the cooled fuel from the cold tank 204 to the heat source cooling system 312.In some examples, the cooled fuel bypasses the cold tank 204 via a first bypass 318.In the illustrated example, the first bypass 318 is disposed between the fuel cooling system 308 and the cold tank 204 along the first fuel path 304.The example first bypass 318 may include a first split 320 to direct cooled fuel from the first fuel path 304 to the second fuel path 306 without flowing the cooled fuel into the cold tank 204.In some examples, the first bypass 318 includes a first valve 322 to control the flow of cooled fuel bypassing the cold tank 204.For example, if the first valve 322 is in a first position, the first bypass 318 may substantially prevent fuel from bypassing the cold tank 204 to fill at least a portion of the cold tank 204 with the cooled fuel.", "If the first valve 322 is in a second position, the first bypass 318 may direct substantially all of the cooled fuel from the fuel cooling system 308 to bypass the cold tank 204 and flow into the heat source cooling system 312.In some examples, the first valve 322 may be in a third position between the first position and the second position in which the first bypass 318 directs some of the cooled fuel to flow into the cold tank 204 and some of the cooled fuel to bypass the cold tank 204.As used herein, the movement of fuel between tanks or conveyed through various fluidic paths or courses can be equivalently described as flowing, transmitting, issuing, conducting, or moving.", "Similarly, the addition of fuel to a tank can be equivalently described as filling or replenishing and the emptying of fuel from a tank can be described as draining or depleting.", "The fuel utilized by the example heat source thermal management system 300 supplies the first engine 108 and/or the second engine 110.In the illustrated example, the first engine 108 receives and/or is fed fuel from the first feed tank 230 during operation of the example aircraft 100.The example second engine 110 may receive and/or be fed fuel from the second feed tank 220.The example cold tank 204 is in fluid communication with the first feed tank 230 and the second feed tank 220 via a second bypass 324.In other examples, the cold tank 204 is in fluid communication with the first feed tank 230, the second feed tank 220, and/or one or more of the other fuel tanks 214, 216, 218, 222, 224, 226, 228, 232, and 234 disposed on the example aircraft 100.In some examples, the second bypass 324 includes a second split 326 and/or a second valve 328 to control the flow of fuel from the cold tank 204 to the first feed tank 230 and/or the second feed tank 220.For example, if the second valve 328 is in a first position, the second valve 328 may substantially prevent fuel in the cold tank 204 from flowing into the first feed tank 230 and/or the second feed tank 220 via the second bypass 324.If the second valve 328 is in a second position, the second bypass 324 may direct substantially all of the fuel flowing from the cold tank 204 to the first feed tank 230 and/or the second feed tank 220.In some examples, the valve may be in a third position between the first position and the second position in which the second bypass 324 directs some of the fuel flowing from the cold tank 204 to flow to the first feed tank 230 and/or the second feed tank 220 and some of the fuel to flow to the heat source cooling system 312.In the illustrated example, the hot tank 202 is in fluid communication with the first feed tank 230 and the second feed tank 220 via a third bypass 330.In other examples, the hot tank 202 is in fluid communication with the first feed tank 230, the second feed tank 220, and/or one or more of the other fuel tanks 214, 216, 218, 222, 224, 226, 228, 232, and 234 disposed on the example aircraft 100.In some examples, the third bypass 330 includes a third split 332 and/or a third valve 334 to control the flow of fuel from the hot tank 202 to the first feed tank 230 and/or the second feed tank 220.For example, if the third valve 334 is in a first position, the third valve 334 may substantially prevent fuel in the hot tank 202 from flowing into the first feed tank 230 and/or the second feed tank 220 via the third bypass 330.If the third valve 334 is in a second position, the third bypass 330 directs substantially all of the fuel flowing from the hot tank 202 to the first feed tank 230 and/or the second feed tank 220.In some examples, the third valve 334 may be in a third position between the first position and the second position in which the third bypass 330 directs some of the fuel flowing from the hot tank 202 to flow to the fuel cooling system 308 and some of the fuel to flow to the first feed tank 230 and/or the second feed tank 220.In the illustrated example, as the fuel flows from the first feed tank 230 to the first engine 108, the fuel is used to cool one or more heat sources 336 via a first heat exchanging system 338.The heat sources 336 may be, for example, components, systems, and/or fluids employed on the aircraft 100.For example, the fuel may be used to cool a generator, hydraulic fluid, oil, etc.", "In some examples, the first heat exchanging system 338 includes one or more heat exchangers, pumps, valves and/or other components.", "Fuel flowing from the second feed tank 220 to the second engine 110 is used to cool one or more heat sources 340 via a second heat exchanging system 342.The heat sources 340 may be, for example, components, systems, and/or fluids employed on the aircraft 100.For example, the fuel may be used to cool a generator, hydraulic fluid, oil, etc.", "In some examples, the second heat exchanging system 342 includes one or more heat exchangers, pumps, valves and/or other suitable components.", "The example heat source thermal management system 300 of FIG.", "3 may also include a fuel flow controller 400 (FIG.", "4).", "As described in greater detail below in conjunction with FIG.", "4, the fuel flow controller 400 controls the flow of fuel through the aircraft 100 and/or example heat source thermal management system 300.For example, the flow controller 400 controls the first pump 310, the second pump 316, the first valve 322, the second valve 328, the third valve 334, and/or other devices to circulate the fuel between the hot tank 202 and the cold tank 204 and/or supply fuel to the first engine 108 and/or the second engine 110.The example aircraft 100 may be operated to carry out a mission.", "The example mission discussed below includes a first stage, a second stage and a third stage in which the example aircraft 100 is used to perform one or more actions.", "For example, the first stage of the mission may include the aircraft 100 taxiing, taking off, flying toward a first destination, etc.", "In some examples, the second stage of the mission includes selectively operating the heat source 302 during flight by, for example, activating a radar system or a weapon system, and the third stage of the mission includes flying the aircraft 100 toward the first destination or a second destination, landing, taxiing, etc.", "However, the example methods and apparatus to cool a heat source disclosed herein may be used in other missions, which may, for example, have other numbers of stages (e.g., 1, 2, 4, 5, etc.", "), involve performing additional and/or different actions, etc.", "During the example mission, the heat source 302 may be in a state or mode such as, for example, a pre-operational mode, a standby mode, an operational mode, a post-operational mode, and/or other modes.", "In some examples, the heat source 302 is cooled based on the mode of the heat source 302, an amount of fuel remaining in the aircraft 100, an action being performed and/or the stage of the mission.", "During the first stage of the mission, the heat source 302 may be in and/or enter the pre-operational mode and/or the standby mode.", "In some examples, the heat source 302 is in the pre-operational mode prior to being cooled below the threshold temperature via the heat source thermal management system 300.For example, the heat source 302 may be in the pre-operational mode prior to flight.", "In some examples, the heat source 302 is in the pre-operational mode until the cold tank 204 is substantially emptied and refilled with cold fuel.", "In some examples, the heat source 302 is in the standby mode when the heat source 302 is within the operational temperature range and the heat source 302 is not being operated.", "In some examples, the fuel utilized to cool the heat source 302 bypasses the cold tank 204 via the first bypass 318 when the heat source 302 is in the pre-operational mode.", "For example, when the heat source 302 is in the pre-operational mode, the heat source 302 is cooled from above the threshold temperature to within the operational temperature range by circulating fuel from the hot tank 202 to the fuel cooling system 308, from the fuel cooling system 308 to the heat source cooling system 312 via the first bypass 318, and from the heat source cooling system 312 to the hot tank 202.In some examples, the fuel is pumped from the hot tank 202 via the first pump 310 through the fuel cooling system 308 at a first flow rate when the heat source 302 is in the pre-operational mode.", "The first flow rate may be, for example, 39.2 pounds per minute.", "In other examples, the first flow rate is other values.", "In some examples, the heat source 302 is heated during the pre-operational mode.", "For example, if the heat source 302 is at a temperature below the operational temperature range and the temperature of the fuel in the hot tank 202 is within or above the operational temperature range, the heat source 302 may be heated by pumping the fuel from the hot tank 202 to the heat source cooling system 312 via, for example, the second fuel flow path 306.Thus, in some examples, the heat source thermal management system 300 may be used to heat the heat source 302.When the temperature of the heat source 302 is within the desired temperature range and the heat source 302 is not being operated, the heat source 302 is in the standby mode.", "In some examples, while the heat source 302 is in the standby mode, the temperature of the heat source 302 is maintained within the desired temperature range by flowing cooled fuel at a second flow rate through the heat source cooling system 312.In some examples, the second flow rate is 23.8 pounds per minute.", "In other examples, the second flow rate is other values.", "The cooled fuel may be flowed to the heat source cooling system 312 from the hot tank 202 via the first bypass 318 and/or from the cold tank 204.In some examples, the temperature of the heat source 302 in the standby mode is maintained within the desired temperature range by periodically flowing cooled fuel through the heat source cooling system 312.In some examples, the heat source 302 is not cooled via the fuel when the heat source 302 is in the standby mode.", "For example, the heat source 302 may not be cooled via the fuel if the heat source 302 does not generate heat when the heat source 302 is in the standby mode.", "During the first stage of the mission, the cold tank 204 and the hot tank 202 may be substantially filled with fuel.", "In some examples, during the first stage of the mission, the fuel stored in the cold tank 204 is supplied to the first engine 108 and/or the second engine 110 while the fuel in the hot tank 202 is used to cool the heat source 302.For example, while the heat source 302 is being cooled by circulating fuel between the hot tank 202 and the heat source cooling system 312 via the first bypass 318, fuel from the cold tank 204 is supplied to the first engine 108 and/or the second engine 110 via the second bypass 324.In some examples, fuel from the cold tank 204 is supplied to the first engine 108 and/or the second engine 110 until the cold tank 204 is substantially empty.", "In some examples, fuel from the hot tank 202 is used to cool the heat source 302 and/or supply the first engine 108 and/or the second engine 110 during the first stage of the mission.", "For example, the fuel from the hot tank 202 may be directed via the third bypass 330 to the first engine 108 and/or the second engine 110 and/or the fuel from the hot tank 202 may be flowed into the cold tank 204.The second stage of the mission may initiate and/or occur after the cold tank 204 has been substantially emptied to supply the first engine 108 and/or the second engine 110 with fuel.", "During the second stage of the mission, the heat source 302 may be in the operational mode or the standby mode.", "In some examples, when the heat source 302 is in the operational mode, the heat source 302 is being operated and generates heat.", "In some examples, the heat source 302 is in the operational mode for a given amount of time (“an operating time”) and then returns to the standby mode.", "Thus, the heat source 302 may periodically operate during the second stage.", "During the second stage of the mission, the fuel from the hot tank 202 is cooled and stored in the cold tank 204.To maintain the heat source 302 within the operational temperature range while the heat source 302 is operating, the cooled fuel is flowed from the cold tank 204 through the heat source cooling system 312 at a third flow rate greater than the first flow rate and the second flow rate.", "For example, the third flow rate may be approximately 1300 pounds per minute.", "However, this is merely an example and, thus, the third flow rate may be other values in other examples.", "In some examples, the cold tank 204 is at least partially filled with the cooled fuel prior to operating the heat source 302.For example, fuel from the hot tank 202 is flowed through the fuel cooling system 308 and into the cold tank 204.In some examples, the cooled fuel is flowed into the cold tank 204 at a fourth flow rate and stored in the cold tank 204 until the heat source 302 is operated.", "In some examples, the fourth flow rate is based on a cooling capacity of the fuel cooling system 308 and/or the first temperature of the fuel stored in the hot tank 202 to enable the fuel to be cooled to the second temperature within a desired amount of time.", "In some examples, the fourth flow rate is about 80 pounds per minute.", "In other examples, the fourth flow rate is other values.", "In some examples, an amount of fuel stored in the cold tank 204 is substantially equal to or greater than an amount of fuel to be flowed through the heat source cooling system 312 to cool the heat source 302 while the heat source 302 is operating.", "When the heat source 302 is operated, the cooled fuel is pumped via the second pump 316 through the heat source cooling system 312 at the third flow rate to absorb at least some of the heat generated by the heat source 302 to maintain the heat source 302 below the threshold temperature and/or within the desired temperature range.", "As the cooled fuel flows through the heat source cooling system 312, the cooled fuel functions as a heat sink and absorbs heat generated by the heat source 302.The cooled fuel then flows from heat source cooling system 312 into the hot tank 202.In some examples, while the cooled fuel is being pumped out of the cold tank 204 to cool the heat source 302, cooled fuel is also pumped into the cold tank 204 from the hot tank 202 at a fifth flow rate such as, for example, 200 pounds per minute to replenish the cold tank 204.In other examples, the cold tank 204 is substantially emptied to cool the heat source 302 over the operating time.", "The cold tank 204 may then be at least partially refilled or replenished with cooled fuel by flowing fuel from the hot tank 202 to the cold tank 204 via the fuel cooling system 308.In some examples, the cooled fuel is stored in the cold tank 204 until the heat source 302 is operated.", "In this manner, the temperature of the heat source 302 may be maintained with the desired temperature range while the heat source 302 is operated one or more times during the second stage of the mission.", "In some examples, during the third stage of the mission, the heat source 302 is in the post-operational mode.", "In some examples, the heat source enters the pre-operational mode and/or the third stage of the mission begins when an amount of fuel remaining in the aircraft 100 is at or below a threshold amount.", "In some examples, the threshold amount is sixteen percent of a total fuel capacity of the aircraft 100.In other examples, the threshold amount corresponds to other percentages of the total fuel capacity of the aircraft 100.In some examples, when the heat source 302 is in the post-operational mode, the fuel in the hot tank 202 and/or the cold tank 204 is supplied to the first engine 108 and/or the second engine 110.Thus, fuel may be flowed into the first feed tank 230 and/or the second feed tank 220 via the second split and/or the third split.", "In some examples, the heat source 302 is cooled by the heat source thermal management system 300 when the heat source 302 is in the post-operational mode.", "In other examples, the heat source 302 is not cooled via the fuel when the heat source 302 is in the post-operational mode.", "During the post-operational mode, cooled fuel may be used to cool the heat source(s) 336, 340 via the first heat exchanging system 338 and the second heat exchanging system 342.In some examples, the cooled fuel sufficiently cools the heat sources(s) 336, 340 in a single pass For example, the cooled fuel may sufficiently cool the heat source(s) 336, 340 without being re-circulated through the first heat exchanging system 338 and/or the second heat exchanging system 342 and, thus, without being reheated.", "As a result, an undesirable increase in the temperature of the fuel or a repeated cycle in which an increase in temperature of the fuel leads to a further increase in temperature of the fuel is substantially prevented and less fuel may be used to cool the heat source(s) 336, 340 than if fuel at the first temperature is employed to cool the heat source(s) 336, 340.Once the cooled fuel flows through the first heat exchanging system 338 and/or the second heat exchanging system 342, the fuel is fed to the first engine 108 and/or the second engine 110.As a result, the example aircraft 100 may conduct the example mission according to a schedule in which approximately 95 percent of the total fuel capacity of the aircraft 100 is used during the mission.", "For example, the aircraft 100 may land following the mission with approximately 5 percent of the total fuel capacity of the aircraft 100 remaining.", "In other examples, the aircraft 100 may use and/or land with other amounts of fuel.", "As discussed above, the flow rate at which the fuel is flowed through the heat source thermal management system 300 via the first pump 310 may be controlled based on an amount of heat generated by the heat source 302 and/or the operational mode of the heat source 302.For example, when the heat source 302 is in the pre-operational mode, the first pump 310 flows the fuel through the fuel cooling system 308 at the first flow rate.", "When the heat source 302 is in the standby mode, the first pump 310 may flow the fuel through the fuel cooling system 308 and the first bypass 318 at a second flow rate to cool the heat source 302.In some examples, when the heat source is in the standby mode, the first pump 310 flows the fuel at the fourth flow rate to fill or replenish at least a portion of the cold tank 204 with cooled fuel.", "When the heat source 302 is in the operating mode, the first pump 310 may flow the fuel at the fourth flow rate to supply the cold tank 204 with cooled fuel while the second pump 316 is flowing cooled fuel through the heat source cooling system 312 at the third flow rate.", "In the illustrated example, the flow rate at which the second pump 316 flows fuel from the cold tank 204 is also based on the amount of heat generated by the heat source 302 and/or operational mode of the heat source 302.For example, when the heat source 302 is in the pre-operational mode, the second pump 316 flows fuel at a sixth flow rate to the first feed tank 230 and/or the second feed tank 220 to supply the first engine 108 and/or the second engine 110 with fuel.", "In some examples, when the heat source 302 is in the standby mode, the second pump 316 flows fuel through the heat source cooling system 312 at the second flow rate.", "When the heat source 302 is in the operational mode, the second pump 316 flows the cooled fuel through the heat source cooling system 312 at the third flow rate.", "In some examples, the first flow rate, the second flow rate, the third flow rate, the fourth flow rate, the fifth flow rate, and/or the six flow rate are adjusted, changed, modulated, varied, and/or fluctuated based on the amount of heat generated by the heat source 302.For example, if the heat generated by the heat source 302 increases while the heat source 302 is operating, the second flow rate may be increased to maintain the temperature of the heat source 302 within the operational range.", "The flow rates and a cooling capacity of the fuel cooling system 308 enable a given amount of the fuel to be cooled from a first temperature to a second temperature in a given amount time.", "The cooling capacity of the fuel cooling system 308 is an amount of heat energy the fuel cooling system 308 can remove from the fuel.", "For example, the fuel cooling system 308 may cool 2,613 pounds of fuel from about 120 degrees Fahrenheit to about 30 degrees Fahrenheit in approximately thirty minutes.", "The flow rates and the cooling capacity of the heat source cooling system 312 enable the heat source 302 to be cooled below the threshold temperature and/or maintain the temperature of the heat source 302 within the operational temperature range.", "The cooling capacity of the heat source cooling system 312 is an amount of heat energy the heat source cooling system 312 can absorb from the heat source 302 via the cooled fuel.", "In some examples, the heat source 302 is selectively and/or periodically operated and/or cooled.", "In other examples, the heat source 302 is substantially continuously operated and/or cooled.", "Thus, the flow rates and the cooling capacities of the fuel cooling system 308 and/or the heat source cooling system 312 employed in the heat source thermal management system 300 may be based on an amount of heat generated by the heat source 302, an operational temperature range of the heat source 302, an operating time of the heat source 302, a frequency of operation of the heat source 302, an amount of space available on a vehicle employing the temperature management system 300 to employ one or more heat exchangers, an amount of fuel available for use in the heat source thermal management system 300, etc.", "While an example manner of implementing the heat source thermal management system 300 is illustrated in FIG.", "3, one or more of the elements, processes and/or devices illustrated in FIG.", "3 may be combined, divided, re-arranged, omitted, eliminated and/or implemented in any other way.", "The example heat source thermal management system 300 of FIG.", "3 may include one or more elements, processes and/or devices in addition to, or instead of, those illustrated in FIG.", "3, and/or may include more than one of any or all of the illustrated elements, processes and devices.", "FIG.", "4 is a block diagram illustrating the example fuel flow controller 400 disclosed herein, which may be used to control the flow of the fuel in the aircraft 100.In the illustrated example, the fuel flow controller 400 is in communication with the first pump 310 of the hot tank 202, a hot tank temperature sensor 402, a hot tank fuel level sensor 404, a cold tank temperature sensor 406, a cold tank fuel level sensor 408, the second pump 316, the first valve 322, the second valve 328, the third valve 334 and one or more vehicle fuel level sensor(s) 410.In the illustrated example, the hot tank temperature sensor 402 is disposed inside the hot tank 202, and the cold tank temperature sensor 406 is disposed inside the cold tank 204.In other examples, the hot tank temperature sensor 402 and/or the cold tank temperature sensor 406 are disposed in other locations within the heat source thermal management system 300.For example, the hot tank temperature sensor 402 may be disposed along the second fuel path 306 (FIG.", "3) downstream of the heat source cooling system 312.In some examples, the cold tank temperature sensor 406 is disposed along the first fuel path 304 (FIG.", "3) downstream of the fuel cooling system 308.In some examples, the fuel flow controller 400 controls the fuel flow into and/or out of the hot tank 202 to cool and/or heat the heat source 302 and/or supply the first engine 108 (FIG.", "1) and/or the second engine 110 (FIG.", "1) with fuel based on a temperature of the hot tank 202, a temperature of the fuel in the hot tank 202, a temperature of the cold tank 204, a temperature of the fuel in the cold tank 204, a level of fuel in the hot tank 202 (e.g., an amount of fuel remaining in the hot tank 202 and/or an amount of space available to receive fuel), a level of fuel in the cold tank 204, a temperature and/or an amount of heat generated by the heat source 302, a mode of operation of the heat source 302 and/or other information.", "In some examples, the fuel flow controller 400 monitors a temperature of the hot tank 202 and/or the temperature of the fuel in the hot tank 202 based on temperature information acquired via the hot tank temperature sensor 402.The example fuel flow controller 400 of FIG.", "4 may also monitor the level of fuel in the hot tank 202 based on information acquired via the hot tank fuel level sensor 404.In some examples, the fuel flow controller 400 controls the fuel flow into and/or out of the cold tank 204 to cool the heat source 302 and/or supply the first engine 108 and/or the second engine 110 with fuel based on the temperature of the hot tank 202, the temperature of the fuel in the hot tank 202, the temperature of the cold tank 204, the temperature of the fuel in the cold tank 204, the level of fuel in the hot tank 202, the level of fuel in the cold tank 204, the temperature and/or amount of heat generated by the heat source 302, the mode of operation of the heat source 302 and/or other information.", "In some examples, the fuel flow controller 400 monitors the temperature of the cold tank 204 and/or the temperature of the fuel in the cold tank 204 based on temperature information acquired via the cold tank temperature sensor 406.The example fuel flow controller 400 of FIG.", "4 may also monitor the level of fuel level in the cold tank 204 by, for example, determining an amount of fuel remaining in the cold tank 204 and/or an amount of space available to receive fuel in the cold tank 204 based on information acquired via the cold tank fuel level sensor 408.For example, if the flow controller 400 determines that the level of fuel in the cold tank 204 is below a first predetermined level, the flow controller 400 may pump fuel from the hot tank 202 to the cold tank 204 via the first pump 310 to substantially fill the cold tank 204.Then, if the temperature of the heat source 302 is above a threshold temperature, the flow controller 400 may pump fuel from the cold tank 204 through the heat source cooling system 312 to cool the heat source 302 and into hot tank 202.If the example flow controller 400 determines that the level of fuel in the cold tank 204 is above the first predetermined level and the level of fuel in the hot tank 202 is above a second predetermined level, the flow controller 400 may supply the first engine 108 and/or the second engine 110 with fuel from the cold tank 204 and/or the hot tank 202 until the level of fuel in the cold tank 204 and/or the hot tank 202 is below the first predetermined level and/or the second predetermined level, respectively.", "Once the level of fuel in the cold tank 204 and/or the hot tank 202 is below the first predetermined level and/or the second predetermined level, respectively, the flow controller 400 may circulate the fuel between the hot tank 202 and the cold tank 204 to cool the heat source 302.In some examples, the flow controller 400 controls different and/or additional devices such as, for example, variable flow pumps, variable position valves, or other devices.", "In some examples, the flow controller 400 employs proportional, integral and/or derivative gain terms.", "In some examples, the flow controller employs table lookup and/or anticipatory control schemes to implement the example heat source thermal management system 300.While an example manner of implementing the example heat source thermal management system 300 of FIG.", "3 is illustrated in FIG.", "4, one or more of the elements, processes and/or devices illustrated in FIG.", "4 may be combined, divided, re-arranged, omitted, eliminated and/or implemented in any other way.", "Further, the example vehicle fuel level sensor(s) 410, the example first bypass 318, the example second bypass 324, the example third bypass 330, the example heat source 302, the example first pump 310, the example hot tank temperature sensor 402, the example hot tank fuel level sensor 404, the example cold tank temperature sensor 406, the example cold tank fuel level sensor 408, the example second pump 316, the example fuel flow controller 400 and/or, more generally, the example heat source thermal management system 300 of FIG.", "4 may be implemented by hardware, software, firmware and/or any combination of hardware, software and/or firmware.", "Thus, for example, any of the example vehicle fuel level sensor(s) 410, the example first bypass 318, the example second bypass 324, the example third bypass 330, the example heat source 302, the example first pump 310, the example hot tank temperature sensor 402, the example hot tank fuel level sensor 404, the example cold tank temperature sensor 406, the example cold tank fuel level sensor 408, the example second pump 316, the example fuel flow controller 400 and/or, more generally, the example heat source thermal management system 300 of FIG.", "4 could be implemented by one or more analog or digital circuit(s), logic circuits, programmable processor(s), application specific integrated circuit(s) (ASIC(s)), programmable logic device(s) (PLD(s)) and/or field programmable logic device(s) (FPLD(s)).", "When reading any of the apparatus or system claims of this patent to cover a purely software and/or firmware implementation, at least one of the example, vehicle fuel level sensor(s) 410, the example first bypass 318, the example second bypass 324, the example third bypass 330, the example heat source 302, the example first pump 310, the example hot tank temperature sensor 402, the example hot tank fuel level sensor 404, the example cold tank temperature sensor 406, the example cold tank fuel level sensor 408, the example second pump 316, the example fuel flow controller 400 and/or, more generally, the example heat source thermal management system 300 of FIG.", "4 is/are hereby expressly defined to include a tangible computer readable storage device or storage disk such as a memory, a digital versatile disk (DVD), a compact disc (CD), a Blu-ray disk, etc.", "storing the software and/or firmware.", "Further still, the example heat source thermal management system 300 of FIG.", "3 may include one or more elements, processes and/or devices in addition to, or instead of, those illustrated in FIG.", "4, and/or may include more than one of any or all of the illustrated elements, processes and devices.", "Flowcharts representative of example methods that may be used to implement the heat source thermal management system 300 of FIG.", "3 are shown in FIGS.", "5-9.The methods may be implemented using machine readable instructions that comprise a program for execution by a processor such as the processor 1012 shown in the example processor platform 1000 discussed below in connection with FIG.", "10.The program may be embodied in software stored on a tangible computer readable storage medium such as a CD-ROM, a floppy disk, a hard drive, a digital versatile disk (DVD), a Blu-ray disk, or a memory associated with the processor 1012, but the entire program and/or parts thereof could alternatively be executed by a device other than the processor 1012 and/or embodied in firmware or dedicated hardware.", "Further, although the example program is described with reference to the flowcharts illustrated in FIGS.", "5-9, many other methods of implementing the example heat source temperature management system 300 may alternatively be used.", "For example, the order of execution of the blocks may be changed, a start and/or an end of each of the methods 500, 600, 800 may occur prior to and/or after different blocks and/or some of the blocks described may be changed, eliminated, or combined.", "As mentioned above, the example methods of FIGS.", "5-9 may be implemented using coded instructions (e.g., computer and/or machine readable instructions) stored on a tangible computer readable storage medium such as a hard disk drive, a flash memory, a read-only memory (ROM), a compact disc (CD), a digital versatile disk (DVD), a cache, a random-access memory (RAM) and/or any other storage device or storage disk in which information is stored for any duration (e.g., for extended time periods, permanently, for brief instances, for temporarily buffering, and/or for caching of the information).", "As used herein, the term tangible computer readable storage medium is expressly defined to include any type of computer readable storage device and/or storage disk and to exclude propagating signals.", "As used herein, “tangible computer readable storage medium” and “tangible machine readable storage medium” are used interchangeably.", "Additionally or alternatively, the example methods of FIGS.", "5-9 may be implemented using coded instructions (e.g., computer and/or machine readable instructions) stored on a non-transitory computer and/or machine readable medium such as a hard disk drive, a flash memory, a read-only memory, a compact disc (CD), a digital versatile disk (DVD), a cache, a random-access memory and/or any other storage device or storage disk in which information is stored for any duration (e.g., for extended time periods, permanently, for brief instances, for temporarily buffering, and/or for caching of the information).", "As used herein, the term non-transitory computer readable medium is expressly defined to include any type of computer readable device or disk and to exclude propagating signals.", "As used herein, when the phrase “at least” is used as the transition term in a preamble of a claim, it is open-ended in the same manner as the term “comprising” is open ended.", "The example method 500 of FIG.", "5 may be used to cool one or more heat sources on a vehicle such as, for example, the heat source 302.The example method 500 of FIG.", "5 begins at block 502 by flowing fuel from a first tank to a second tank via a first fuel path.", "For example, fuel may be flowed from the hot tank 202 to the cold tank 204 via the first fuel path 304.The fuel is cooled from a first temperature to a second temperature along the first fuel path (block 504).", "For example, the fuel is flowed through a heat exchanger of the fuel cooling system 308 disposed along the first fuel path 304.The fuel may be flowed through any type of heat exchanger such as, for example, an air-to-fuel heat exchanger, a refrigerant-to-fuel heat exchanger, etc.", "At block 506, at least a portion of the second tank is filled with the fuel.", "In some examples, the second tank includes the thermal insulation such as, for example, the thermal insulation 212 to reduce and/or minimize an amount of heat energy absorbed by the fuel while the fuel is stored in the second tank.", "At block 508, a heat source is operated.", "For example, a weapon system may be activated, a radar system may be activated, and/or any other heat source(s) may be operated.", "When the heat source is operated, the heat source generates heat.", "At block 510, fuel is flowed from the second tank into a heat exchanger to cool the heat source.", "The heat exchanger may be any type of heat exchanger such as, for example, a water-to-fuel heat exchanger of the heat source cooling system 312 of FIG.", "3.At block 512, the fuel is flowed from the heat exchanger to the first tank.", "Thus, the fuel is circulated between the first tank and the second tank to cool the heat source.", "In some examples, the fuel from the second tank is substantially emptied into the first tank.", "At block 514, at least a portion of the first tank is filled with the fuel.", "The example method 500 of FIG.", "5 then returns to block 502 to enable the heat source to be periodically and/or substantially continuously cooled.", "FIG.", "6 is a flowchart representative of another example method 600 disclosed herein.", "The example method 600 of FIGS.", "6-7 is used to cool the example heat source 302 of FIG.", "3 during a mission having three stages.", "However, the example method 600 of FIGS.", "6-7 may be used to cool any other heat source on any vehicle.", "Also, while the example method 600 of FIGS.", "6-7 involves a mission having three stages, other examples cool one or more heat sources during missions having other numbers of stages (e.g., 1, 2, 4, 5, etc.).", "In the illustrated example, the aircraft 100 is substantially fully fueled during an initial portion of the first stage of the mission.", "For example, the tanks 202, 204, 214, 216, 218, 220, 222, 224, 226, 228, 230, 232 and 234 may be substantially filled with fuel at an outset of the mission.", "In other examples, the aircraft 100 initially has other amounts of fuel.", "For example, the aircraft 100 may be filled with an amount of fuel corresponding to, for example, half, two-thirds, three-quarters, etc.", "of a total fuel capacity of the aircraft 100.As the mission is carried out, the first engine 108 and the second engine 110 are supplied with the fuel, thereby decreasing an amount of fuel remaining on the aircraft 100.In the example method 600 of FIGS.", "6-7, the heat source 302 is cooled based on a mode of operation of the heat source 302 and/or an amount of fuel remaining in the aircraft 100 during the mission.", "The example method 600 of FIG.", "6 begins by determining if the heat source 302 is in the pre-operational mode (block 602).", "In some examples, the heat source 302 is in the pre-operational mode if a temperature of the heat source 302 is above a threshold temperature and/or outside of an operational temperature range.", "In some examples, the heat source 302 is above the threshold temperature during a portion of the mission.", "For example, the heat source 302 may be above the threshold temperature during a first stage of the mission.", "In other examples, the heat source 302 is at or below the threshold temperature throughout the mission and, thus, does not enter the pre-operational mode.", "For example, the heat source 302 may be in the standby mode or the operational mode at the outset of the mission.", "In some examples, the heat source 302 is in the pre-operational mode if hot tank 202 and the cold tank 204 are substantially filled with fuel.", "In some examples, the fuel in the cold tank 204 is supplied to the first engine 108 and/or the second engine 110 during a first stage of a mission when the hot tank 202 and the cold tank 204 are substantially filled with fuel to provide space in the cold tank 204 to receive cooled fuel.", "Thus, in the illustrated example, if it is determined that the heat source 302 is in a pre-operational mode at block 602, fuel is flowed from the cold tank 204 to supply an engine with the fuel (block 604).", "In some examples, fuel is not flowed from the cold tank 204 and/or the hot tank 202 to supply an engine such as, for example, the first engine 108 and/or the second engine 110 with fuel during the first stage of the mission, the second stage of the mission, and/or the third stage of the mission.", "In the illustrated example, if the heat source 302 is in the pre-operational mode, fuel is also flowed from the hot tank 202 to the fuel cooling system 308 to cool the fuel (block 606).", "The fuel cooling system 308 cools the fuel from the first temperature to the second temperature less than the first temperature.", "For example, the fuel cooling system 308 may cool the fuel from 120 degrees Fahrenheit to 30 degrees Fahrenheit.", "The fuel is flowed from the fuel cooling system 308 to the heat source cooling system 312, bypassing the cold tank 204, to cool the heat source 302 (block 608).", "The fuel is returned to the hot tank 202 (block 610).", "If the heat source temperature is above a threshold temperature (block 612), the example method 600 returns to block 606.In some example, the heat source 302 is below the threshold temperature during the first stage of the mission and, therefore, is not cooled via the fuel until the heat source 302 is operated and/or generates heat.", "If the heat source temperature is below the threshold temperature (block 612), the heat source 302 may be in a standby mode or an operational mode and, thus, the example method 600 proceeds to block 700, which is discussed in greater detail below.", "As discussed above in conjunction with block 604, if the heat source 302 is in the pre-operational mode, the fuel is flowed from the cold tank 204 to supply the engine with the fuel.", "In the illustrated example, the cold tank 204 is substantially emptied during the first stage of the mission.", "If it is determined that the cold tank 204 is substantially empty (block 614), fuel is supplied to the engine from another tank (block 616), and the example method 600 proceeds to block 612.For example, the fuel may be supplied by one or more of the tanks 214, 216, 218, 220, 222, 224, 226, 228, 230, 232 and 234 of FIG.", "2.In other examples, the cold tank 204 is not substantially emptied during the first stage of the mission.", "If the heat source 302 is not in the pre-operational mode (block 602) or if the heat source temperature is below the threshold temperature (block 612), it is determined if the heat source 302 is in standby mode (block 700) (FIG.", "7).", "In some examples, the heat source 302 is in the standby mode if the heat source 302 is below the threshold temperature and/or within the operational temperature range and the heat source 302 is not operating.", "In some examples, the heat source 302 enters the standby mode when the example cold tank 204 is substantially empty.", "Referring to FIG.", "7, if the heat source 302 is in the standby mode, it is determined if the cold tank 204 is substantially full (block 702).", "If the cold tank 204 is not substantially full, fuel is flowed from the hot tank 202 to the fuel cooling system 308 to cool the fuel (block 704).", "In some examples, the first pump 310 pumps the fuel from the hot tank 202 at the fourth flow rate.", "At block 706, a portion of the cold tank 204 is filled with the cooled fuel.", "The example method 600 then returns to block 702 and it is determined if the cold tank 204 is substantially full.", "If the cold tank 204 is substantially full, the flow of fuel into the cold tank 204 is stopped (block 707), and the example method 600 returns to block 700.Thus, in the illustrated example, the cold tank 204 is substantially filled with cooled fuel while the heat source 302 is in the standby mode.", "In some examples, a portion of the fuel in the cold tank 204 is flowed from the cold tank 204 to cool the heat source 302 when the heat source 302 is in the standby mode.", "In other examples, the heat source 302 is not cooled via the cooled fuel when the heat source 302 is in the standby mode.", "If the heat source 302 is not in the standby mode, it is determined if the heat source 302 is in an operational mode (block 708).", "In the illustrated example, the heat source 302 enters the operational mode during the second stage of the mission.", "In some examples, the heat source 302 may be in the operational mode during the second stage and/or other stages of the mission.", "For example, the heat source 302 may be in the operational mode substantially throughout the mission, during the first stage and/or the third stage, etc.", "In some examples, the heat source 302 in the operational mode is being selectively operated and generates heat.", "If the heat source 302 is in the operational mode, the fuel in the cold tank 204 is flowed to the heat source cooling system 312 to cool the heat source 302 (block 710).", "In some examples, the second pump 316 pumps the fuel at the third flow rate such as, for example, 1370 pounds per minute.", "In some examples, a flow rate of the cooled fuel pumped by the second pump 316 varies based on amount of heat generated by the heat source 302 while the heat source 302 is in the operational mode.", "The cooled fuel passes through the heat source cooling system 312 and into the hot tank 202.At block 712, the hot tank 202 is at least partially filled with the fuel In the illustrated example, the heat source 302 is cooled based on the amount of fuel remaining in the aircraft 100 during the mission.", "At block 714, it is determined if an amount of fuel remaining on the aircraft 100 is less than a predetermined amount.", "If the amount of fuel remaining is above the predetermined amount, the example method 700 returns to block 706, and at least a portion of the cold tank 204 is filled with cooled fuel.", "In this manner, the heat source 302 may be periodically and/or substantially continuously cooled via the cooled fuel.", "If the amount of fuel remaining is less than the predetermined amount, the heat source 302 enters a post-operational mode (block 716).", "In other examples, the heat source 302 enters the post-operational mode based on other prompts, factors and/or conditions such as, for example, a depletion of weaponry, entering a different stage of the mission, a user command, etc.", "In the illustrated example, if the heat source 302 is in the post-operational mode, the engine is supplied with fuel from at least one of the hot tank 202 or the cold tank 204 (block 718).", "In some examples, fuel is flowed from the cold tank 204 to the first engine 108 via the second bypass 324 and/or fuel is flowed from the hot tank 202 to the second engine 110 via the third bypass 330.In some examples, the fuel is used to cool one or more components and/or fluids such as, for example, hydraulic fluid, oil, etc.", "on the aircraft 100 as the fuel is directed from the heat source thermal management system 300 to the first engine 108 and/or the second engine 110.For example, the fuel may be used to cool the one or more components via the first heat exchanging system 338 and/or the second heat exchanging system 342 of FIG.", "3.FIGS.", "8-9 illustrate a flowchart representative of another example method 800 disclosed herein.", "The example method 800 of FIGS.", "8-9 may be used to cool the example heat source 302 of FIG.", "3 and/or any other vehicle heat source.", "The example method 800 begins by the flow controller 400 determining if the cold tank 204 is substantially full (block 802).", "In other examples, the flow controller 400 determines if the fuel in the cold tank 204 is above and/or below a predetermined level.", "If the cold tank 204 is substantially full, the flow controller 400 determines if a cold tank temperature is at or below a threshold temperature (block 804).", "For example, the flow controller 400 may determine if a temperature of the hot tank 202 and/or a temperature of the fuel in the cold tank 204 is below the threshold temperature.", "If the cold tank temperature is at or below the threshold temperature, the flow controller 400 determines if the hot tank 202 is able to receive fuel from the cold tank 204 (block 806).", "For example, the flow controller 400 may determine a first level of fuel in the hot tank 202 via the hot tank fuel level sensor 404 and a second level of fuel in the cold tank 204 via the cold tank fuel level sensor 408.Based on the first level and the second level, the flow controller 400 may determine if the hot tank 204 has volume available to receive some or all of the fuel in the cold tank 204.If the hot tank 202 is not able to receive fuel from the cold tank 204, an engine is supplied with fuel from the hot tank 202 (block 808).", "For example, the flow controller 400 may control the third valve 334 to enable the fuel to flow from the hot tank 202 to the second feed tank 220 via the third bypass 330.The example method 800 then returns to block 802.If the hot tank 202 is able to receive fuel from the cold tank 204 (block 806), the flow controller 400 determines if the heat source 302 is above a threshold temperature (block 810).", "If the heat source 302 is not above the threshold temperature, the example method 800 returns to block 802.If the heat source 302 is above the threshold temperature, the flow controller 400 flows fuel from the cold tank 204 through the heat source cooling system 312 to the hot tank 202 (block 812).", "As the fuel flows through the heat source cooling system 312, the example heat source 302 is cooled.", "The example method then returns to block 802.Returning to block 802, if the cold tank 204 is not substantially full, the flow controller 400 determines if the fuel level in the hot tank 202 is sufficient to fill the cold tank 204 (block 814).", "If the fuel level in the hot tank 202 is sufficient to fill the cold tank 204, the engine(s) 108, 110 are supplied with fuel from a tank other than the hot tank 202 and the cold tank 204 (block 816).", "For example, the first engine 108 and/or the second engine 110 may be supplied with fuel from one or more of the tanks 214, 216, 218, 220, 222, 224, 226, 228, 230, 232 and 234.Fuel is flowed from the hot tank 202 to the fuel cooling system 308 to cool the fuel (block 818).", "The fuel cooling system 308 cools the fuel.", "The flow controller 400 determines if the heat source 302 is above the threshold temperature (block 820).", "If the heat source 302 is not above the threshold temperature, fuel is flowed from the fuel cooling system 308 to the cold tank 204 (block 822).", "The flow controller 400 determines if the fuel level of the cold tank 204 is above a predetermined level (block 824).", "In some examples, if the fuel level of the cold tank 204 is above the predetermined level, the example heat source 302 may be operated, and the fuel in the cold tank 204 may be used to cool the heat source 302.The example method 800 then returns to block 802.Returning to block 820, if the heat source 302 is above the threshold temperature, the flow controller 400 determines if the cold tank temperature is at or below the threshold temperature (block 826).", "If the cold tank temperature is above the threshold temperature, the flow controller 400 flows fuel from the fuel cooling system 308 to the heat source cooling system 312 (block 828).", "For example, the flow controller 400 may control the second valve 328 to enable the fuel to bypass the cold tank 204.The example method then returns to block 802.If the cold tank temperature is at or below the threshold temperature (block 826), the flow controller 400 flows fuel from the fuel cooling system 308 to the cold tank 204 (block 830).", "Then, flow controller 400 flows fuel from the cold tank 204 through the heat source cooling system 312 to the hot tank (block 812).", "As a result, the heat source 302 is cooled, and the example method returns to block 802.If the cold tank 204 is substantially full (block 802) and the cold tank temperature is at or below the threshold temperature (block 804), the flow controller 400 determines if the fuel level in the hot tank 202 is at or below a threshold level (block 832).", "If the fuel level in the hot tank 204 is above the threshold level, the engine(s) 108, 110 are supplied with fuel from the cold tank 204 (block 834).", "In some examples, if the cold tank 204 is substantially full and the fuel level in the hot tank 202 is above the threshold level, fuel may not be flowed from the cold tank 204 to the hot tank 202 or from the hot tank 202 to the cold tank 204.Thus, the flow controller 400 may control the second valve 328 to flow the fuel to the first feed tank 230 via the second bypass 324 to decrease the level of fuel in the cold tank 204 to enable the cold tank 204 to receive fuel from the hot tank 202.In other examples, fuel from the hot tank 202 is used to supply the engine(s) 108, 110.If the fuel level in the hot tank 202 is below the threshold level, the engine(s) 108, 110 are supplied with fuel from a tank other than the hot tank 202 and the cold tank 204 (block 818).", "If the cold tank 204 is not substantially full (block 802) and the fuel level in the hot tank 202 is not sufficient to fill the cold tank 204, the flow the flow controller 400 determines if a vehicle fuel level is below a predetermined level (block 900).", "For example, the flow controller 400 may determine an amount of fuel remaining in the aircraft 100.If the vehicle fuel level is at or above the predetermined level, the flow controller 400 fills the hot tank 202 with fuel from at least one of the tanks other than the hot tank 202 and the cold tank 204 (block 902).", "For example, the flow controller 400 may fill the hot tank 202 with fuel from one or more of the tanks 214, 216, 218, 220, 222, 224, 226, 228, 230, 232 and 234.In some examples, the flow controller 400 may monitor the vehicle fuel level via the vehicle fuel level sensor(s) 410.If the vehicle fuel level falls below the predetermined level, the flow controller 400 supplies the engine(s) 108, 110 with fuel from the hot tank 202 and the cold tank (block 904).", "FIG.", "10 is a block diagram of an example processor platform 1000 capable of executing the methods of FIGS.", "5-9 to implement the flow controller 400 and/or the heat source thermal management system 200 of FIGS.", "3-4.The processor platform 1000 can be, for example, a server, a computer, an Internet appliance, or any other type of computing device.", "The processor platform 1000 of the illustrated example includes a processor 1012.The processor 1012 of the illustrated example is hardware.", "For example, the processor 1012 can be implemented by one or more integrated circuits, logic circuits, microprocessors or controllers from any desired family or manufacturer.", "The processor 1012 of the illustrated example includes a local memory 1013 (e.g., a cache).", "The processor 1012 of the illustrated example is in communication with a main memory including a volatile memory 1014 and a non-volatile memory 1016 via a bus 1018.The volatile memory 1014 may be implemented by Synchronous Dynamic Random Access Memory (SDRAM), Dynamic Random Access Memory (DRAM), RAMBUS Dynamic Random Access Memory (RDRAM) and/or any other type of random access memory device.", "The non-volatile memory 1016 may be implemented by flash memory and/or any other desired type of memory device.", "Access to the main memory 1014, 1016 is controlled by a memory controller.", "The processor platform 1000 of the illustrated example also includes an interface circuit 1020.The interface circuit 1020 may be implemented by any type of interface standard, such as an Ethernet interface, a universal serial bus (USB), and/or a PCI express interface.", "In the illustrated example, one or more input devices 1022 are connected to the interface circuit 1020.The input device(s) 1022 permit(s) a user to enter data and commands into the processor 1012.The input device(s) can be implemented by, for example, a keyboard, a button, a mouse, a touchscreen, a track-pad, a trackball, isopoint and/or a voice recognition system.", "One or more output devices 1024 are also connected to the interface circuit 1020 of the illustrated example.", "The output devices 1024 can be implemented, for example, by display devices (e.g., a light emitting diode (LED), an organic light emitting diode (OLED), a liquid crystal display, a cathode ray tube display (CRT), a touchscreen, a tactile output device, a light emitting diode (LED), a printer and/or speakers).", "The interface circuit 1020 of the illustrated example, thus, typically includes a graphics driver card, a graphics driver chip or a graphics driver processor.", "The interface circuit 1020 of the illustrated example also includes a communication device such as a transmitter, a receiver, a transceiver, a modem and/or network interface card to facilitate exchange of data with external machines (e.g., computing devices of any kind) via a network 1026 (e.g., an Ethernet connection, a digital subscriber line (DSL), a telephone line, coaxial cable, a cellular telephone system, etc.).", "The processor platform 1000 of the illustrated example also includes one or more mass storage devices 1028 for storing software and/or data.", "Examples of such mass storage devices 1028 include floppy disk drives, hard drive disks, compact disk drives, Blu-ray disk drives, Redundant Disk Array (RAID) systems, and digital versatile disk (DVD) drives.", "The coded instructions 1032 of FIG.", "10 may be stored in the mass storage device 1028, in the volatile memory 1014, in the non-volatile memory 1016, and/or on a removable tangible computer readable storage medium such as a CD or DVD.", "Although certain example methods, apparatus and articles of manufacture have been described herein, the scope of coverage of this patent is not limited thereto.", "On the contrary, this patent covers all methods, apparatus and articles of manufacture fairly falling within the scope of the claims of this patent." ] ]
Patent_15875958
[ [ "INTELLIGENT SENSOR AND CONTROLLER FRAMEWORK FOR THE POWER GRID", "Disclosed below are representative embodiments of methods, apparatus, and systems for monitoring and using data in an electric power grid.", "For example, one disclosed embodiment comprises a sensor for measuring an electrical characteristic of a power line, electrical generator, or electrical device; a network interface; a processor; and one or more computer-readable storage media storing computer-executable instructions.", "In this embodiment, the computer-executable instructions include instructions for implementing an authorization and authentication module for validating a software agent received at the network interface; instructions for implementing one or more agent execution environments for executing agent code that is included with the software agent and that causes data from the sensor to be collected; and instructions for implementing an agent packaging and instantiation module for storing the collected data in a data container of the software agent and for transmitting the software agent, along with the stored data, to a next destination." ], [ "1-19.", "(canceled) 20.A computer-implemented method, comprising: loading data defining an uninitiated software agent, the data defining the uninitiated software agent comprising executable code for performing an agent task; identifying one or more destination nodes to which the software agent is to be transmitted; generating data defining an initiated software agent, the data defining the initiated software agent comprising immutable data that indicates identities of the one or more destination nodes and indicates configuration parameters for the agent task, data indicating an identity of an initiator of the initiated software agent, data indicating an cryptographic signature of the initiated software agent, and the executable code for performing the agent task; and transmitting the data defining the initiated software agent to one of the one or more of the destination nodes.", "21.The method of claim 20, wherein the method is performed by computing hardware associated with a feeder in a power grid and wherein the one or more destination nodes are nodes corresponding to homes powered by the feeder.", "22.The method of claim 20, wherein the data defining the uninitiated software agent includes data indicating a cryptographic signature of the uninitiated software agent signed by a creator of the uninitiated software agent, and wherein the method further comprises determining that the uninitiated software agent is authorized based at least in part on the cryptographic signature of the uninitiated software agent signed by the creator.", "23.The method of claim 20, wherein the data defining the uninitiated software agent and the data defining the initiated software agent include data indicating resource requirements for executing the software agent.", "24.The method of claim 20, wherein one or more of the destination nodes are communicatively coupled to (a) a sensor for measuring an electrical parameter of a power line of a power grid, (b) a sensor for measuring an electrical parameter of a distributed generator coupled to the power grid, (c) an electrical meter for a household coupled to the power grid, (d) a control unit for one or more household electrical devices that receive power from the power grid, or (e) a control unit for controlling power distribution on the power grid.", "25.The method of claim 20, wherein the method is performed by computing hardware associated with a first hierarchical level of a power grid, and wherein the data defining the uninitiated software agent is sent from computing hardware associated with a second hierarchical level of the power grid at a higher level than the first hierarchical level.", "26.The method of claim 25, wherein the data defining the uninitiated software agent includes data indicating a cryptographic signature for the uninitiated software agent generated by the computing hardware associated with the second hierarchical level of the power grid, and wherein the method further comprises determining that the uninitiated software agent is authorized based at least in part on the cryptographic signature for the uninitiated software agent generated by the computing hardware associated with the second hierarchical level of the power grid.", "27.One or more computer-readable media storing computer-executable instructions, which when executed by a computer cause the computer to perform the method of claim 20.28.A circuit comprising computing hardware configured to perform the method of claim 20.29.A computer-implemented method, comprising: generating data defining an uninitiated software agent, the data including executable code for performing an agent task, data indicating an identity of a creator of the uninitiated software agent, and data indicating computing resources required to perform the agent task; and storing the uninitiated software agent on one or more computer-readable storage media.", "30.The method claim 29, wherein the data defining an uninitiated software agent further includes data indicating an cryptographic signature signed by the creator of the uninitiated software agent.", "31.The method claim 29, wherein the agent task is performed at least in part by (a) a sensor for measuring an electrical parameter of a power line of a power grid, (b) a sensor for measuring an electrical parameter of a distributed generator coupled to the power grid, (c) an electrical meter for a household coupled to the power grid, (d) a control unit for one or more household electrical devices that receive power from the power grid, or (e) a power distribution control device coupled to the power grid.", "32.One or more computer-readable media storing computer-executable instructions, which when executed by a computer cause the computer to perform the method of claim 29.33-39.", "(canceled) 40.A method, comprising: receiving information indicative of an energy use goal for one or more distribution power lines in a power network for a time period; receiving information from one or more remote households coupled to respective ones of the distribution power lines, the information from the one or more remote households comprising information indicating an energy demand priority level for each respective remote household; determining an energy demand priority level for a local household; and determining whether to activate one or more electrical devices at the local household during the time period based at least in part on the information indicative of the energy use goal, the information indicating the energy demand priority level for each respective remote household, and the energy demand priority level for the local household.", "41.The method of claim 40, wherein the determination of whether to activate the one or more electrical devices at the local household during the time period is made using a set of rules that is common among the local household and the one or more remote households.", "42.The method of claim 41, wherein the set of rules allows a household with a higher energy demand priority level to draw additional power before a household with a lower energy demand priority level.", "43.The method of claim 40, wherein the determination of whether to activate the one or more electrical devices at the local household during the time period is made using a set of rules that is defined in executable code sent to the local household using a software agent.", "44.The method of claim 40, wherein the information received from the one or more remote households is stored as data in a software agent that is sent by a respective one of the one or more household to the local household via a network.", "45.The method of claim 40, further comprising selectively activating the one or more electrical devices at the local household based on the determination of whether to activate the one or more electrical devices at the local household during the time period.", "46.The method of claim 40, further comprising transmitting information indicative of the energy demand priority level for the local household to the one or more remote households using a software agent.", "47.One or more computer-readable media storing computer-executable instructions, which when executed by a computer cause the computer to perform the method of claim 40.48.A circuit comprising computing hardware configured to perform the method of claim 40." ], [ "<SOH> BACKGROUND <EOH>The number of sensors and controllers connected to the electric power system is expected to grow by several orders of magnitude over the next several years.", "However, the information networks that are currently used to transmit and analyze data on the system are ill-equipped to handle the volume of communications resulting from the increased number of sensors.", "For example, the current information networks are incapable of delivering large amounts of data collected by the sensors in a predictable, time-effective, and reliable manner.", "Without the ability to manage and use data from the sensors, the deployment of sensors into the power grid (e.g., phasor measurement sensors into the transmission system and smart meters into the distribution system) will not result in the desired improvements.", "For example, conventional information networks for power system are incapable of managing two-way power flow, thus hampering efforts to fully utilize distributed generation capabilities (e.g., power generation from home solar panels, electric vehicles, and the like).", "Accordingly, improved systems, methods, and apparatus for managing and using data in an electric power grid are desired." ], [ "<SOH> SUMMARY <EOH>Disclosed below are representative embodiments of methods, apparatus, and systems for monitoring and using data in an electric power grid.", "Certain embodiments, for example, bring intelligence from the control rooms of a utility to devices located at or near customer premises.", "The application of the disclosed embodiments to electrical utilities and to a power grid should not be construed as limiting, however, as the disclosed technology is more generally applicable to other environments in which agent-based data communications are desired.", "Among the exemplary embodiments disclosed herein is a method that comprises receiving data representing a software agent, the data including data indicating a cryptographic signature for the software agent, data indicating resource requirements for executing the software agent, and executable code for performing an agent task; determining that the executable code is authorized for execution; and executing the executable code on a processor, thereby performing the agent task.", "In this exemplary method, the determining that the executable code is authorized for execution comprises verifying that the software agent is authorized using the data indicating the cryptographic signature, and verifying that sufficient computing resources are available for the software agent using the data indicating the resource requirements.", "In certain implementations, the data representing the software agent further comprises data indicating an identity of an initiator of the software agent, and the act of determining that the executable code is authorized for execution further comprises verifying that the initiator is a recognized and authorized initiator using the data indicating the identity of the initiator of the software agent.", "In some implementations, the data representing the software agent further comprises data indicating a cryptographic signature for configuration data of the software agent (the configuration data indicating parameters for the executable code and destination nodes for the software agent), and the act of determining that the executable code is authorized for execution further comprises verifying that the configuration data of the software agent has not been altered using the cryptographic signature for the configuration data.", "In certain implementations, the data representing the software agent further comprises data indicating a cryptographic signature for mutable data of the software agent, and the act of determining that the executable code is authorized for execution further comprises verifying that the mutable data of the software agent has not been altered using the cryptographic signature for the mutable data.", "In some implementations, the method is performed by computing hardware in communication with one of (a) a sensor for measuring an electrical parameter of a power line of a power grid, (b) a sensor for measuring an electrical parameter of a distributed generator coupled to the power grid, (c) an electrical meter for a household coupled to the power grid, (d) a control unit for one or more household electrical devices that receive power from the power grid, or (e) a control unit for controlling power distribution on the power grid.", "In certain implementations, the act of executing the executable code comprises instantiating an instance of an agent execution environment, and executing the executable code in the agent execution environment.", "In some implementations, the agent task is to update agent code for an existing agent.", "In certain implementations, the method further comprises receiving data from a sensor as a result of executing the executable code on the processor; storing the collected data in a mutable data container of the software agent; and transmitting the software agent, along with the collected data, to a next destination in a manner in which the mutable data container is protected from tampering during transmission.", "The sensor in such implementations can be configured to measure an electrical characteristic of a power line, a distributed generator, or an electrical device.", "Another exemplary embodiment disclosed herein is a system comprising a sensor for measuring an electrical characteristic of a power line, electrical generator, or electrical device; a network interface; a processor; and one or more computer-readable storage media storing computer-executable instructions.", "In this embodiment, the computer-executable instructions include instructions for implementing an authorization and authentication module for validating a software agent received at the network interface; instructions for implementing one or more agent execution environments for executing agent code that is included with the software agent and that causes data from the sensor to be collected; and instructions for implementing an agent packaging and instantiation module for storing the collected data in a data container of the software agent and for transmitting the software agent, along with the stored data, to a next destination.", "In certain implementations, the sensor is a phasor measurement sensor.", "In some implementations, the system is part of an electrical meter for a household on a power grid, or a control unit for one or more household electrical devices that receive power from the power grid.", "In further implementations, the system is part of a control unit in communication with a power grid.", "In certain implementations, the one or more computer-readable media further store data indicative of cryptographically verifiable identities, the data indicative of cryptographically verifiable identities being used by the authorization and authentication module to validate the software agent.", "In some implementations, the one or more computer-readable media further store data indicative of a network identity for the next destination, the network identity being used by the agent packaging and instantiation module to transmit the software agent to the next destination.", "In certain implementations, the one or more computer-readable media further store instructions for controlling an information exchange bus that facilitates communication to the one or more agent execution environments.", "In some implementations, the instructions for implementing the one or more agent execution environments include instructions for executing an agent written in a first language in a first execution environment and instructions for executing an agent written in a second language in a second execution environment different from the first execution environment.", "Another of the exemplary embodiments disclosed herein is a method that comprises loading data defining an uninitiated software agent, the data defining the uninitiated software agent comprising executable code for performing an agent task; identifying one or more destination nodes to which the software agent is to be transmitted; generating data defining an initiated software agent, the data defining the initiated software agent comprising immutable data that indicates identities of the one or more destination nodes and further indicates configuration parameters for the agent task, data indicating an identity of an initiator of the initiated software agent, data indicating an cryptographic signature of the initiated software agent, and the executable code for performing the agent task.", "The method further comprises transmitting the data defining the initiated software agent to one of the one or more of the destination nodes.", "In certain implementations, the method is performed by computing hardware associated with a feeder in a power grid and the one or more destination nodes are nodes corresponding to homes powered by the feeder.", "In some implementations, the data defining the uninitiated software agent includes data indicating a cryptographic signature of the uninitiated software agent signed by a creator of the uninitiated software agent, and the method further comprises determining that the uninitiated software agent is authorized based at least in part on the cryptographic signature of the uninitiated software agent signed by the creator.", "In certain implementations, the data defining the uninitiated software agent and the data defining the initiated software agent include data indicating resource requirements for executing the software agent.", "In some implementations, one or more of the destination nodes are communicatively coupled to (a) a sensor for measuring an electrical parameter of a power line of a power grid, (b) a sensor for measuring an electrical parameter of a distributed generator coupled to the power grid, (c) an electrical meter for a household coupled to the power grid, (d) a control unit for one or more household electrical devices that receive power from the power grid, or (e) a control unit for controlling power distribution on the power grid.", "In certain implementations, the method is performed by computing hardware associated with a first hierarchical level of a power grid, and the data defining the uninitiated software agent is sent from computing hardware associated with a second hierarchical level of the power grid at a higher level than the first hierarchical level.", "In some implementations, the data defining the uninitiated software agent includes data indicating a cryptographic signature for the uninitiated software agent generated by the computing hardware associated with the second hierarchical level of the power grid, and the method further comprises determining that the uninitiated software agent is authorized based at least in part on the cryptographic signature for the uninitiated software agent generated by the computing hardware associated with the second hierarchical level of the power grid.", "A further exemplary embodiment disclosed herein is a method that comprises generating data defining an uninitiated software agent, the data including executable code for performing an agent task, data indicating an identity of a creator of the uninitiated software agent, and data indicating computing resources required to perform the agent task; and storing the uninitiated software agent on one or more computer-readable storage media.", "In some implementations, the data defining an uninitiated software agent further includes data indicating a cryptographic signature signed by the creator of the uninitiated software agent.", "In certain implementations, the agent task is performed at least in part by (a) a sensor for measuring an electrical parameter of a power line of a power grid, (b) a sensor for measuring an electrical parameter of a distributed generator coupled to the power grid, (c) an electrical meter for a household coupled to the power grid, (d) a control unit for one or more household electrical devices that receive power from the power grid, or (e) a control unit for controlling power distribution on the power grid.", "Another of the exemplary embodiments disclosed herein is a method that comprises transmitting an outgoing software agent to one or more nodes on a network, wherein at least one of the nodes is communicatively coupled to (a) a sensor for measuring an electrical parameter of a power line of a power grid, (b) a sensor for measuring an electrical parameter of a distributed generator coupled to the power grid, (c) an electrical meter for a household coupled to the power grid, (d) a control unit for one or more household electrical devices that receive power from the power grid, or (e) a power distribution control device coupled to the power grid, and wherein the outgoing software agent includes resource information indicating resources used to execute the software agent and a cryptographic signature for the software agent; and, after the transmission of the outgoing software agent, receiving an incoming software agent that includes data collected from the one or more nodes on the network.", "In some implementations, the outgoing software agent comprises executable code for collecting data indicative of an operational state of one or more distributed generators coupled to the power grid, and the incoming software agent includes the data indicative of the operational state of the one or more distributed generators.", "In certain implementations, the outgoing software agent comprises executable code for collecting data indicative of an operational state of one or more power lines coupled to the power grid, and the incoming software agent includes the data indicative of the operational state of the one or more power lines.", "In some implementations, the outgoing software agent comprises executable code for collecting data indicating one or more of an identity, location, or electrical characteristics of electrical devices associated with each of the one or more nodes, and the incoming software agent includes the data indicating one or more of the identity, location, or electrical characteristics of the electrical devices associated with each of the one or more nodes.", "In certain implementations, the outgoing software agent comprises executable code for collecting data indicative of a fault location among the one or more nodes, and the incoming software agent includes the data indicative of the fault location among the one or more nodes.", "Another of the exemplary methods disclosed herein is a method that comprises receiving information indicative of an energy use goal for one or more distribution power lines in a power network for a time period; receiving information from one or more remote households coupled to respective ones of the distribution power lines, the information from the one or more remote households comprising information indicating an energy demand priority level for each respective remote household; determining an energy demand priority level for a local household; and determining whether to activate one or more electrical devices at the local household during the time period based at least in part on the information indicative of the energy use goal, the information indicating the energy demand priority level for each respective remote household, and the energy demand priority level for the local household.", "In certain implementations, the determination of whether to activate the one or more electrical devices at the local household during the time period is made using a set of rules that is common among the local household and the one or more remote households.", "In some implementations, the set of rules allows a household with a higher energy demand priority level to draw additional power before a household with a lower energy demand priority level.", "In certain implementations, the determination of whether to activate the one or more electrical devices at the local household during the time period is made using a set of rules that is defined in executable code sent to the local household using a software agent.", "In some implementations, the information received from the one or more remote households is stored as data in a software agent that is sent by a respective one of the one or more household to the local household via a network.", "In certain implementations, the method further comprises selectively activating the one or more electrical devices at the local household based on the determination of whether to activate the one or more electrical devices at the local household during the time period.", "In some implementations, the method further comprises transmitting information indicative of the energy demand priority level for the local household to the one or more remote households using a software agent.", "Embodiments of the disclosed methods can be performed using computing hardware, such as a computer processor, application specific integrated circuit, or programmable logic device.", "For example, embodiments of the disclosed methods can be performed by software stored on one or more non-transitory computer-readable media (e.g., one or more volatile memory components (such as DRAM or SRAM) or nonvolatile memory or storage components (such as hard drives)).", "Such software can be executed on a single computer or on a networked computer (e.g., via the Internet, a wide-area network, a local-area network, a client-server network, or other such network).", "Embodiments of the disclosed methods can also be performed by specialized computing hardware (e.g., one or more application specific integrated circuits (“ASICs”) or programmable logic devices (such as field programmable gate arrays (“FPGAs”)) configured to perform any of the disclosed methods).", "Additionally, any intermediate or final result created or modified using any of the disclosed methods can be stored on a non-transitory storage medium (e.g., volatile memory or storage components (such as DRAM or SRAM) or nonvolatile memory or storage components (such as hard drives)) and are considered to be within the scope of this disclosure.", "Furthermore, any of the software embodiments (comprising, for example, computer-executable instructions which when executed by a computer cause the computer to perform any of the disclosed methods), intermediate results, or final results created or modified by the disclosed methods can be transmitted, received, or accessed through a suitable communication means.", "The foregoing and other objects, features, and advantages of the invention will become more apparent from the following detailed description, which proceeds with reference to the accompanying figures." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a divisional of U.S. patent application Ser.", "No.", "14/746,577, filed Jun.", "22, 2015, which is a divisional of prior U.S. patent application Ser.", "No.", "13/204,606, filed Aug. 5, 2011 (now U.S. Pat.", "No.", "9,094,385), which applications are hereby incorporated by reference in their entirety.", "ACKNOWLEDGMENT OF GOVERNMENT SUPPORT This invention was made with Government support under Contract DE-AC05-76RL01830 awarded by the U.S. Department of Energy.", "The Government has certain rights in the invention.", "FIELD This application relates generally to the field of power grid monitoring and control.", "BACKGROUND The number of sensors and controllers connected to the electric power system is expected to grow by several orders of magnitude over the next several years.", "However, the information networks that are currently used to transmit and analyze data on the system are ill-equipped to handle the volume of communications resulting from the increased number of sensors.", "For example, the current information networks are incapable of delivering large amounts of data collected by the sensors in a predictable, time-effective, and reliable manner.", "Without the ability to manage and use data from the sensors, the deployment of sensors into the power grid (e.g., phasor measurement sensors into the transmission system and smart meters into the distribution system) will not result in the desired improvements.", "For example, conventional information networks for power system are incapable of managing two-way power flow, thus hampering efforts to fully utilize distributed generation capabilities (e.g., power generation from home solar panels, electric vehicles, and the like).", "Accordingly, improved systems, methods, and apparatus for managing and using data in an electric power grid are desired.", "SUMMARY Disclosed below are representative embodiments of methods, apparatus, and systems for monitoring and using data in an electric power grid.", "Certain embodiments, for example, bring intelligence from the control rooms of a utility to devices located at or near customer premises.", "The application of the disclosed embodiments to electrical utilities and to a power grid should not be construed as limiting, however, as the disclosed technology is more generally applicable to other environments in which agent-based data communications are desired.", "Among the exemplary embodiments disclosed herein is a method that comprises receiving data representing a software agent, the data including data indicating a cryptographic signature for the software agent, data indicating resource requirements for executing the software agent, and executable code for performing an agent task; determining that the executable code is authorized for execution; and executing the executable code on a processor, thereby performing the agent task.", "In this exemplary method, the determining that the executable code is authorized for execution comprises verifying that the software agent is authorized using the data indicating the cryptographic signature, and verifying that sufficient computing resources are available for the software agent using the data indicating the resource requirements.", "In certain implementations, the data representing the software agent further comprises data indicating an identity of an initiator of the software agent, and the act of determining that the executable code is authorized for execution further comprises verifying that the initiator is a recognized and authorized initiator using the data indicating the identity of the initiator of the software agent.", "In some implementations, the data representing the software agent further comprises data indicating a cryptographic signature for configuration data of the software agent (the configuration data indicating parameters for the executable code and destination nodes for the software agent), and the act of determining that the executable code is authorized for execution further comprises verifying that the configuration data of the software agent has not been altered using the cryptographic signature for the configuration data.", "In certain implementations, the data representing the software agent further comprises data indicating a cryptographic signature for mutable data of the software agent, and the act of determining that the executable code is authorized for execution further comprises verifying that the mutable data of the software agent has not been altered using the cryptographic signature for the mutable data.", "In some implementations, the method is performed by computing hardware in communication with one of (a) a sensor for measuring an electrical parameter of a power line of a power grid, (b) a sensor for measuring an electrical parameter of a distributed generator coupled to the power grid, (c) an electrical meter for a household coupled to the power grid, (d) a control unit for one or more household electrical devices that receive power from the power grid, or (e) a control unit for controlling power distribution on the power grid.", "In certain implementations, the act of executing the executable code comprises instantiating an instance of an agent execution environment, and executing the executable code in the agent execution environment.", "In some implementations, the agent task is to update agent code for an existing agent.", "In certain implementations, the method further comprises receiving data from a sensor as a result of executing the executable code on the processor; storing the collected data in a mutable data container of the software agent; and transmitting the software agent, along with the collected data, to a next destination in a manner in which the mutable data container is protected from tampering during transmission.", "The sensor in such implementations can be configured to measure an electrical characteristic of a power line, a distributed generator, or an electrical device.", "Another exemplary embodiment disclosed herein is a system comprising a sensor for measuring an electrical characteristic of a power line, electrical generator, or electrical device; a network interface; a processor; and one or more computer-readable storage media storing computer-executable instructions.", "In this embodiment, the computer-executable instructions include instructions for implementing an authorization and authentication module for validating a software agent received at the network interface; instructions for implementing one or more agent execution environments for executing agent code that is included with the software agent and that causes data from the sensor to be collected; and instructions for implementing an agent packaging and instantiation module for storing the collected data in a data container of the software agent and for transmitting the software agent, along with the stored data, to a next destination.", "In certain implementations, the sensor is a phasor measurement sensor.", "In some implementations, the system is part of an electrical meter for a household on a power grid, or a control unit for one or more household electrical devices that receive power from the power grid.", "In further implementations, the system is part of a control unit in communication with a power grid.", "In certain implementations, the one or more computer-readable media further store data indicative of cryptographically verifiable identities, the data indicative of cryptographically verifiable identities being used by the authorization and authentication module to validate the software agent.", "In some implementations, the one or more computer-readable media further store data indicative of a network identity for the next destination, the network identity being used by the agent packaging and instantiation module to transmit the software agent to the next destination.", "In certain implementations, the one or more computer-readable media further store instructions for controlling an information exchange bus that facilitates communication to the one or more agent execution environments.", "In some implementations, the instructions for implementing the one or more agent execution environments include instructions for executing an agent written in a first language in a first execution environment and instructions for executing an agent written in a second language in a second execution environment different from the first execution environment.", "Another of the exemplary embodiments disclosed herein is a method that comprises loading data defining an uninitiated software agent, the data defining the uninitiated software agent comprising executable code for performing an agent task; identifying one or more destination nodes to which the software agent is to be transmitted; generating data defining an initiated software agent, the data defining the initiated software agent comprising immutable data that indicates identities of the one or more destination nodes and further indicates configuration parameters for the agent task, data indicating an identity of an initiator of the initiated software agent, data indicating an cryptographic signature of the initiated software agent, and the executable code for performing the agent task.", "The method further comprises transmitting the data defining the initiated software agent to one of the one or more of the destination nodes.", "In certain implementations, the method is performed by computing hardware associated with a feeder in a power grid and the one or more destination nodes are nodes corresponding to homes powered by the feeder.", "In some implementations, the data defining the uninitiated software agent includes data indicating a cryptographic signature of the uninitiated software agent signed by a creator of the uninitiated software agent, and the method further comprises determining that the uninitiated software agent is authorized based at least in part on the cryptographic signature of the uninitiated software agent signed by the creator.", "In certain implementations, the data defining the uninitiated software agent and the data defining the initiated software agent include data indicating resource requirements for executing the software agent.", "In some implementations, one or more of the destination nodes are communicatively coupled to (a) a sensor for measuring an electrical parameter of a power line of a power grid, (b) a sensor for measuring an electrical parameter of a distributed generator coupled to the power grid, (c) an electrical meter for a household coupled to the power grid, (d) a control unit for one or more household electrical devices that receive power from the power grid, or (e) a control unit for controlling power distribution on the power grid.", "In certain implementations, the method is performed by computing hardware associated with a first hierarchical level of a power grid, and the data defining the uninitiated software agent is sent from computing hardware associated with a second hierarchical level of the power grid at a higher level than the first hierarchical level.", "In some implementations, the data defining the uninitiated software agent includes data indicating a cryptographic signature for the uninitiated software agent generated by the computing hardware associated with the second hierarchical level of the power grid, and the method further comprises determining that the uninitiated software agent is authorized based at least in part on the cryptographic signature for the uninitiated software agent generated by the computing hardware associated with the second hierarchical level of the power grid.", "A further exemplary embodiment disclosed herein is a method that comprises generating data defining an uninitiated software agent, the data including executable code for performing an agent task, data indicating an identity of a creator of the uninitiated software agent, and data indicating computing resources required to perform the agent task; and storing the uninitiated software agent on one or more computer-readable storage media.", "In some implementations, the data defining an uninitiated software agent further includes data indicating a cryptographic signature signed by the creator of the uninitiated software agent.", "In certain implementations, the agent task is performed at least in part by (a) a sensor for measuring an electrical parameter of a power line of a power grid, (b) a sensor for measuring an electrical parameter of a distributed generator coupled to the power grid, (c) an electrical meter for a household coupled to the power grid, (d) a control unit for one or more household electrical devices that receive power from the power grid, or (e) a control unit for controlling power distribution on the power grid.", "Another of the exemplary embodiments disclosed herein is a method that comprises transmitting an outgoing software agent to one or more nodes on a network, wherein at least one of the nodes is communicatively coupled to (a) a sensor for measuring an electrical parameter of a power line of a power grid, (b) a sensor for measuring an electrical parameter of a distributed generator coupled to the power grid, (c) an electrical meter for a household coupled to the power grid, (d) a control unit for one or more household electrical devices that receive power from the power grid, or (e) a power distribution control device coupled to the power grid, and wherein the outgoing software agent includes resource information indicating resources used to execute the software agent and a cryptographic signature for the software agent; and, after the transmission of the outgoing software agent, receiving an incoming software agent that includes data collected from the one or more nodes on the network.", "In some implementations, the outgoing software agent comprises executable code for collecting data indicative of an operational state of one or more distributed generators coupled to the power grid, and the incoming software agent includes the data indicative of the operational state of the one or more distributed generators.", "In certain implementations, the outgoing software agent comprises executable code for collecting data indicative of an operational state of one or more power lines coupled to the power grid, and the incoming software agent includes the data indicative of the operational state of the one or more power lines.", "In some implementations, the outgoing software agent comprises executable code for collecting data indicating one or more of an identity, location, or electrical characteristics of electrical devices associated with each of the one or more nodes, and the incoming software agent includes the data indicating one or more of the identity, location, or electrical characteristics of the electrical devices associated with each of the one or more nodes.", "In certain implementations, the outgoing software agent comprises executable code for collecting data indicative of a fault location among the one or more nodes, and the incoming software agent includes the data indicative of the fault location among the one or more nodes.", "Another of the exemplary methods disclosed herein is a method that comprises receiving information indicative of an energy use goal for one or more distribution power lines in a power network for a time period; receiving information from one or more remote households coupled to respective ones of the distribution power lines, the information from the one or more remote households comprising information indicating an energy demand priority level for each respective remote household; determining an energy demand priority level for a local household; and determining whether to activate one or more electrical devices at the local household during the time period based at least in part on the information indicative of the energy use goal, the information indicating the energy demand priority level for each respective remote household, and the energy demand priority level for the local household.", "In certain implementations, the determination of whether to activate the one or more electrical devices at the local household during the time period is made using a set of rules that is common among the local household and the one or more remote households.", "In some implementations, the set of rules allows a household with a higher energy demand priority level to draw additional power before a household with a lower energy demand priority level.", "In certain implementations, the determination of whether to activate the one or more electrical devices at the local household during the time period is made using a set of rules that is defined in executable code sent to the local household using a software agent.", "In some implementations, the information received from the one or more remote households is stored as data in a software agent that is sent by a respective one of the one or more household to the local household via a network.", "In certain implementations, the method further comprises selectively activating the one or more electrical devices at the local household based on the determination of whether to activate the one or more electrical devices at the local household during the time period.", "In some implementations, the method further comprises transmitting information indicative of the energy demand priority level for the local household to the one or more remote households using a software agent.", "Embodiments of the disclosed methods can be performed using computing hardware, such as a computer processor, application specific integrated circuit, or programmable logic device.", "For example, embodiments of the disclosed methods can be performed by software stored on one or more non-transitory computer-readable media (e.g., one or more volatile memory components (such as DRAM or SRAM) or nonvolatile memory or storage components (such as hard drives)).", "Such software can be executed on a single computer or on a networked computer (e.g., via the Internet, a wide-area network, a local-area network, a client-server network, or other such network).", "Embodiments of the disclosed methods can also be performed by specialized computing hardware (e.g., one or more application specific integrated circuits (“ASICs”) or programmable logic devices (such as field programmable gate arrays (“FPGAs”)) configured to perform any of the disclosed methods).", "Additionally, any intermediate or final result created or modified using any of the disclosed methods can be stored on a non-transitory storage medium (e.g., volatile memory or storage components (such as DRAM or SRAM) or nonvolatile memory or storage components (such as hard drives)) and are considered to be within the scope of this disclosure.", "Furthermore, any of the software embodiments (comprising, for example, computer-executable instructions which when executed by a computer cause the computer to perform any of the disclosed methods), intermediate results, or final results created or modified by the disclosed methods can be transmitted, received, or accessed through a suitable communication means.", "The foregoing and other objects, features, and advantages of the invention will become more apparent from the following detailed description, which proceeds with reference to the accompanying figures.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a schematic block diagram of a computing environment that can be used to implement embodiments of the disclosed technology.", "FIG.", "2 is a schematic block diagram illustrating an exemplary hierarchy of scopes of influence according to which agents in embodiments of the disclosed technology are organized.", "FIG.", "3 is a schematic block diagram illustrating an overall architecture of an exemplary software framework in embodiments of the disclosed agent-based system.", "FIG.", "4 is a schematic block diagram illustrating components of an exemplary intelligent sensor or controller agent framework used in embodiments of the disclosed agent-based system.", "FIG.", "5 is another schematic block diagram illustrating components of an exemplary intelligent sensor or controller agent framework used in embodiments of the disclosed agent-based system.", "FIG.", "6 is a schematic block diagram illustrating components of an exemplary agent transport payload for agents used in embodiments of the disclosed agent-based system.", "FIG.", "7 is a schematic block diagram illustrating exemplary basic agent operations performed by a creator and an initiator in embodiments of the disclosed agent-based system.", "FIG.", "8 is a flow chart of an exemplary method for creating an agent according to an embodiment of the disclosed technology.", "FIGS.", "9A and 9B are flow charts for an exemplary method of initiating an agent and receiving an agent according to an embodiment of the disclosed technology.", "FIGS.", "10A and 10B are flow charts for an exemplary method of executing an agent at a node according to an embodiment of the disclosed technology.", "FIG.", "11 is a flow chart for an exemplary method for upgrading an agent according to an embodiment of the disclosed technology.", "FIG.", "12 is a flow chart for an exemplary method of authenticating and authorizing an agent according to an embodiment of the disclosed technology.", "FIGS.", "13A and 13B are flow charts for an exemplary method of performing load sequencing according to an embodiment of the disclosed technology.", "FIG.", "14 shows graphs reporting results from a simulation of embodiments of the disclosed technology.", "FIG.", "15 is a schematic block diagram illustrating the topology and agent movement for one example scenario.", "DETAILED DESCRIPTION I.", "General Considerations Disclosed below are representative embodiments of methods, apparatus, and systems for monitoring and controlling a power grid.", "Particular embodiments are directed toward monitoring and controlling the power grid using an agent-based approach.", "The disclosed methods, apparatus, and systems should not be construed as limiting in any way.", "Instead, the present disclosure is directed toward all novel and nonobvious features and aspects of the various disclosed embodiments, alone and in various combinations and subcombinations with one another.", "Furthermore, any features or aspects of the disclosed embodiments can be used in various combinations and subcombinations with one another.", "The disclosed methods, apparatus, and systems are not limited to any specific aspect or feature or combination thereof, nor do the disclosed embodiments require that any one or more specific advantages be present or problems be solved.", "Although the operations of some of the disclosed methods are described in a particular, sequential order for convenient presentation, it should be understood that this manner of description encompasses rearrangement, unless a particular ordering is required by specific language set forth below.", "For example, operations described sequentially may in some cases be rearranged or performed concurrently.", "Moreover, for the sake of simplicity, the attached figures may not show the various ways in which the disclosed methods can be used in conjunction with other methods.", "Additionally, the description sometimes uses terms like “determine” and “generate” to describe the disclosed methods.", "These terms are high-level abstractions of the actual operations that are performed.", "The actual operations that correspond to these terms may vary depending on the particular implementation and are readily discernible by one of ordinary skill in the art.", "Furthermore, as used herein, the term “and/or” means any one item or combination of items in the phrase.", "Any of the disclosed methods can be implemented using computer-executable instructions stored on one or more computer-readable media (e.g., non-transitory computer-readable media, such as one or more optical media discs, volatile memory components (such as DRAM or SRAM), or nonvolatile memory components (such as hard drives)) and executed on a computer (e.g., any commercially available computer).", "Any of the computer-executable instructions for implementing the disclosed techniques (e.g., the disclosed agent generation, agent execution, agent upgrading, agent authorization, load sequencing, or other techniques) as well as any intermediate or final data created and used during implementation of the disclosed agent-based systems can be stored on one or more computer-readable media (e.g., non-transitory computer-readable media).", "The computer-executable instructions can be part of, for example, a dedicated software application or as part of an agent's transport payload that is accessed or downloaded via a network (e.g., a local-area network, a wide-area network, a client-server network, or other such network).", "Such software can be executed on a single computer (e.g., a computer embedded in or electrically coupled to a sensor, controller, or other device in the power grid) or in network environment.", "For example, the software can be executed by a computer embedded in or communicatively coupled to a sensor for measuring electrical parameters of a power line or electrical device, a synchrophasor sensor, a smart meter, a control unit for a home or household appliance or system (e.g., an air-conditioning unit; heating unit; heating, ventilation, and air conditioning (“HVAC”) system; hot water heater; refrigerator; dish washer; washing machine; dryer; oven; microwave oven; pump; home lighting system; electrical charger; electric vehicle charger; home electrical system; or any other electrical system having variable performance states), a control unit for a distributed generator (e.g., photovoltaic arrays, wind turbines, or electric battery charging systems), a control unit for controlling the distribution of power along the power grid (e.g., a transformer, switch, circuit breaker, or any other device on the power grid configured to perform a control action), and the like.", "Further, any of the control units can also include or receive information from one or more sensors.", "For clarity, only certain selected aspects of the software-based embodiments are described.", "Other details that are well known in the art are omitted.", "For example, it should be understood that the software-based embodiments are not limited to any specific computer language or program.", "For instance, embodiments of the disclosed technology can be implemented by software written in C++, Java, Perl, JavaScript, Adobe Flash, Python, JINI, .NET, Lua or any other suitable programming language.", "Likewise, embodiments of the disclosed technology are not limited to any particular computer or type of hardware.", "Details of suitable computers and hardware are well known and need not be set forth in detail in this disclosure.", "Furthermore, any of the software-based embodiments (comprising, for example, computer-executable instructions which when executed by a computer cause the computer to perform any of the disclosed methods) can be uploaded, downloaded, or remotely accessed through a suitable communication means.", "Such suitable communication means include, for example, the Internet, the World Wide Web, an intranet, software applications, cable (including fiber optic cable), magnetic communications, electromagnetic communications (including RF, microwave, and infrared communications), electronic communications, or other such communication means.", "The disclosed methods can also be implemented by specialized computing hardware that is configured to perform any of the disclosed methods.", "For example, the disclosed methods can be implemented by a computing device comprising an integrated circuit (e.g., an application specific integrated circuit (“ASIC”) or programmable logic device (“PLD”), such as a field programmable gate array (“FPGA”)).", "The integrated circuit or specialized computing hardware can be embedded in or directly coupled to a sensor, control unit, or other device in the power grid.", "For example, the integrated circuit can be embedded in or otherwise coupled to a synchrophasor sensor, smart meter, control unit for a home or household appliance or system, a control unit for a distributed generator, a control unit for controlling power distribution on the grid, or other such device.", "FIG.", "1 illustrates a generalized example of a suitable computing hardware environment 100 for a computing device with which several of the described embodiments can be implemented.", "The computing environment 100 is not intended to suggest any limitation as to the scope of use or functionality of the disclosed technology, as the techniques and tools described herein can be implemented in diverse general-purpose or special-purpose environments that have computing hardware.", "With reference to FIG.", "1, the computing environment 100 includes at least one processing unit 110 and memory 120.In FIG.", "1, this most basic configuration 130 is included within a dashed line.", "The processing unit 110 executes computer-executable instructions.", "In a multi-processing system, multiple processing units execute computer-executable instructions to increase processing power.", "The memory 120 may be volatile memory (e.g., registers, cache, RAM), non-volatile memory (e.g., ROM, EEPROM, flash memory), or some combination of the two.", "The memory 120 stores software 180 for implementing one or more of the described techniques for operating or using the disclosed agent-based systems.", "For example, the memory 120 can store software 180 for implementing any of the disclosed agents or agent control techniques.", "The computing environment can have additional features.", "For example, the computing environment 100 includes storage 140, one or more input devices 150, one or more output devices 160, and one or more communication connections 170.An interconnection mechanism (not shown) such as a bus, controller, or network interconnects the components of the computing environment 100.Typically, operating system software (not shown) provides an operating environment for other software executing in the computing environment 100, and coordinates activities of the components of the computing environment 100.The storage 140 can be removable or non-removable, and includes magnetic disks, magnetic tapes or cassettes, CD-ROMs, DVDs, or any other tangible non-transitory storage medium which can be used to store information and which can be accessed within the computing environment 100.The storage 140 can also store instructions for the software 180 implementing any of the described techniques, systems, or environments.", "The input device(s) 150 can be a touch input device such as a keyboard, mouse, touch screen, pen, or trackball, a voice input device, a scanning device, or another device that provides input to the computing environment 100.The output device(s) 160 can be a display, touch screen, printer, speaker, or another device that provides output from the computing environment 100.The communication connection(s) 170 enable communication over a communication medium to another computing entity.", "The communication medium conveys information such as computer-executable instructions, the agent transport payload, or other data in a modulated data signal.", "A modulated data signal is a signal that has one or more of its characteristics set or changed in such a manner as to encode information in the signal.", "By way of example, and not limitation, communication media include wired or wireless techniques implemented with an electrical, optical, RF, infrared, acoustic, or other carrier.", "The various methods, systems, and interfaces disclosed herein can be described in the general context of computer-executable instructions stored on one or more computer-readable media.", "Computer-readable media are any available media that can be accessed within or by a computing environment.", "By way of example, and not limitation, with the computing environment 100, computer-readable media include tangible non-transitory computer-readable media, such as memory 120 and storage 140.The various methods, systems, and interfaces disclosed herein can also be described in the general context of computer-executable instructions, such as those included in program modules, being executed in a computing environment on a target processor.", "Generally, program modules include routines, programs, libraries, objects, classes, components, data structures, and the like that perform particular tasks or implement particular abstract data types.", "The functionality of the program modules may be combined or split between program modules as desired in various embodiments.", "Computer-executable instructions for program modules may be executed within a local or distributed computing environment.", "II.", "Introduction to the Disclosed Technology Embodiments of the disclosed technology involve adding intelligence to the sensors, controllers, actuators, and other devices (e.g., smart meters, control units for homes and/or household appliances, control units for distributed generators, and control units used to control power distribution on the power grid) being used in the electric power system.", "Using embodiments of the disclosed technology, sensors and/or controllers in the electric power system are capable of sharing information through the various layers of the electric power system.", "Further, the two-way information enabled by the disclosed technology facilitates the integration of distributed resources into the power grid.", "Several techniques are disclosed, including the use of peer-to-peer communication as well as distributed agents.", "Sensors in the power system that can adapted to use embodiments of the disclosed technology include, for example, synchrophasor sensors that are deployed throughout the system, power measurement sensors, current meters, voltage meters, sensors detecting drag or stretch on a transmission line, smart meters, sensors coupled to distributed power generation devices (e.g., photovoltaic arrays, wind turbines, electric vehicle charging stations, and the like), sensors coupled to household devices (e.g., responsive air-conditioning units; heating units; heating, ventilation, and air conditioning (“HVAC”) systems; hot water heaters; refrigerators; dish washers; washing machines; dryers; ovens; microwave ovens; pumps; home lighting systems; electrical chargers; electric vehicle chargers; home electrical systems; or any other electrical system having variable performance states), and the like.", "These sensors can be operable to measure a wide variety of electrical parameters of the power line, generator, or device with which they are associated.", "For example, depending on the application, a sensor can be configured to measure power usage, voltage, current, phase angle, and/or other such electrical parameters.", "Control units in the power system that can be adapted to use embodiments of the disclosed technology include, for example, control units for distributed power generation devices (e.g., photovoltaic arrays, wind turbines, electric vehicle charging stations, and the like), home power management systems, control units for household devices (e.g., responsive air-conditioning units; heating units; heating, ventilation, and air conditioning (“HVAC”) systems; hot water heaters; refrigerators; dish washers; washing machines; dryers; ovens; microwave ovens; pumps; home lighting systems; electrical chargers; electric vehicle chargers; home electrical systems; or any other electrical system having variable performance states), control units for controlling the distribution of power along the power grid (e.g., transformers, switches, circuit breakers, or any other device on the power grid configured to perform a control action), and the like.", "Further, any of the control units can also include or receive information from one or more sensors.", "For example, a control unit for a hot water heater can be coupled to a sensor for measuring a current energy level in the hot water heater.", "In particular embodiments, the disclosed software agents operate on systems with differing levels of computing power.", "The agents can cooperate to bring computation closer to the data.", "The types of computation can include control decisions, data analysis, and/or demand/response decisions.", "When paired with distributed autonomous controllers, the sensors form the basis of an information system that supports deployment of both micro-grids and islanding.", "For example, embodiments of the disclosed technology form the basis for a broad strategy that enables better integration of distributed generation, distribution automation systems, and decentralized control (e.g., microgrids).", "In particular embodiments, the disclosed software platform for implementing software agents is used at the distribution layer of the electric power system, where end customers are being served.", "In general, the agents described herein comprise software entities that are capable of accomplishing a given task on their own.", "Also described herein are embodiments of a software framework (also referred to as a “software platform”) for using agents that is adapted specifically for the power grid network.", "III.", "Exemplary Agent-Based Software Frameworks for Monitoring and Controlling a Power Grid A.", "Introduction In this section, examples of a suitable software platform (or framework) for supporting adaptive and intelligent sensors, controllers, and electric devices on a power grid are described.", "Embodiments of the disclosed software platform involve an agent-based architecture that is capable of autonomous or substantially autonomous operation.", "For example, certain embodiments involve moving the control and decision-making aspects of the power grid toward the edges of the system, thus enhancing distributed operation and increasing both efficiency and reliability.", "For instance, embodiments of the disclosed software agents can operate as distributed entities, which are given a task to complete and which are capable of cooperating with each other to accomplish the task.", "Further, embodiments of the disclosed software platform are designed to support both mobile and stationary agents.", "Some embodiments of the disclosed intelligent sensors, intelligent controllers, and associated agent-based framework are capable of operating autonomously without requiring intervention from a centralized control point.", "They can adapt and tailor their measurement methods based on environmental conditions and perform multiple types of measurements belonging to different domains to enable localized autonomous control while also communicating this information back to a system operations center.", "Alternatively, measurements from multiple single-purpose sensors may be combined by an intelligent sensor aggregator to support legacy sensors that already exist in the power grid The disclosed embodiments of the software platform can exhibit a number of possible advantages, any one or more of which can be present in an implementation of the disclosed technology.", "For example, embodiments of the disclosed software platform can help (1) meet real-time (or substantially real-time) data processing requirements; (2) improve control system response times by locating intelligence closer to the control points; (3) adjust automatically the resolution and frequency of data being sent across the sensor network based on current state of the systems being observed by the sensor; (4) explore new ways of correlating data from multiple domains such as power systems and network security; (5) create the information channels to enable two-way power flows to speed up the integration of distributed generation in the power system; (6) increase the scalability of the information networks in the electric power grid; and/or (7) allow decentralized control to support micro-grids and islanding.", "B.", "Principles of Operation This section describes generally how agents implemented according to embodiments of the disclosed software framework can operate in a power system.", "Before describing the agent operational concepts, the hierarchical organization of embodiments of the disclosed technology are described.", "In particular, the organizational boundary (termed a “scope of influence” or “SOT”) that can be used by agents operating according to the disclosed software framework is described.", "1.Scopes of Influence The electric power system generally follows a fairly hierarchical organizational structure.", "A country is divided into regions.", "In each region, there are typically balancing authorities, regional transmission operators, power generation suppliers, and distribution utilities.", "Within a distribution utility, electric power flows through distribution lines to distribution substations and then to feeder lines that deliver power to customer premises.", "In certain embodiments of the disclosed technology, the intelligence and distributed computing capabilities follow a substantially similar organizational structure.", "In the discussion below, the organizational boundary is referred to as the “scope of influence” or “SOT”.", "In particular, the SOT refers to an organizational boundary within which a set of software agents can communicate, cooperate, and exchange information.", "In certain embodiments, an SOT has one or more non-human “initiators” (e.g., computing entities) that are responsible for initiating and distributing tasks to agents as well as providing ancillary services to the agents within an SOT.", "These ancillary services can include (but are not limited to) agent discovery and directory services, and trust services (e.g., reputation management and trust negotiation).", "An initiator may also participate in network services, such as routing and name resolution.", "In certain embodiments, each SOT has a unique identifier.", "This unique identifier may be constructed by combining a name, a location, and/or a network address.", "In general, the initiator can be implemented using any embodiment of the computing devices described herein (e.g., a computer having an architecture such as shown in FIG.", "1).", "Furthermore, within the SOL the initiator may be located at a central location or a location suitable for the power grid operator to easily control and monitor the initiator (e.g., in a feeder SOI, the initiator can be located at the distribution substation where the feeder originates).", "FIG.", "2 is a schematic block diagram 200 illustrating multiple SOIs.", "In the illustrated embodiment, five SOIs are shown, though more or fewer SOIs can exist.", "In FIG.", "2, the following SOIs are illustrated: utility SOI 210, substation SOI 212, feeder SOI 214, and customer premises SOI 216.Further, even though only a single example of each SOI is illustrated in FIG.", "2, it is to be understood that on account of the hierarchical structure of the power grid, each SOI can include two or more SOIs at the next lower-order hierarchical level.", "For example, within a utility SOI, there can be multiple substation SOIs.", "Within a substation SOI, there can be multiple feeder SOIs.", "Within a feeder SOI, there can be multiple customer premises SOIs.", "Note also that while the utility, substation, and feeder SOIs can be under the same administrative authority, the customer premises SOI is more than likely under a different administrative authority.", "In particular, the customer premises SOI is likely controlled by the customer (e.g., using a home energy management system, multiple responsive home appliances, or the like).", "Also illustrated in FIG.", "2 is a third-party SOI 220, which represents entities that are not utilities and not owned by a utility that perform functions within the power system.", "The third-party SOI 220 can be, for example, a virtual power plant provider (e.g., a group of distributed generation installations that are collectively run by a central control entity).", "Note that a customer may choose to trust a third party SOI, even if the utility serving the customer does not.", "In one exemplary implementation of the software framework (referred to as the “representative framework”), the framework exhibits the characteristics described below.", "It is to be understood, however, that other embodiments within the scope of this disclosure can exhibit only one or more or none of these characteristics.", "In the representative framework, each SOI has at least one initiator that is responsible for assigning tasks and dispatching agents within the SOI.", "The task assignment can be performed on the basis of the agent capabilities (examples of which are discussed more fully below).", "The initiator can also facilitate ancillary services including directory services, trust and reputation management, and communication between this SOI and its parent SOI.", "While the initiator can itself be considered an agent; it is stationary in the representative framework and has closer integration with the software platform than other software agents.", "If there is more than one initiator in an SOI, it is assumed that one of the initiators is selected as the initiator (e.g., by the utility or by the initiators collaborating to choose) with all other initiators in the SOI serving the master initiator.", "Further, in particular implementations, the initiators are provisioned by the administrator of the SOI at system configuration time.", "In the representative framework, the administrator of an SOI can upload/enable agents to be run within an SOI.", "If an administrator manages multiple SOIs, then an agent can be enabled to run within multiple SOIs (e.g., either by separately initiating the agent within each SOI or by initiating a single agent that is assigned to multiple SOIs).", "In the representative framework, each SOI has a policy for determining whether an agent is authorized to run within the SOI.", "This policy is based on factors such as the agent creator's and initiator's trust levels, verification that the agent has not been tampered with and activity-specific authorizations for each type of activity to be performed by the agent.", "Further, the configuration policies module at an SOI can indicate that any agent from a particular creator or SOI is to be trusted (or not).", "Additionally, the configuration policies module for an SOI can have: (1) a policy that describes additional authorization requirements (such as trust negotiation) for allowing agents from other SOIs to execute within the SOI; (2) a policy that defines the specific actions that agents from other SOIs are allowed to perform; (3) a policy that describes the allowed communications between agents within an SOI; and/or (4) a policy that describes the allowed communications between agents within the SOI and agents in other SOIs.", "2.Overview of the Operation of Agents An agent comprises a software entity that is capable of accomplishing a given task on its own.", "In particular, an agent comprises a piece of software (e.g., a set of computer-executable instructions) or software module that acts for a user or other program in a relationship of agency when executed.", "In the representative framework, an agent's purpose is to accomplish a task assigned to it by the initiator in the SOI that the agent resides in.", "An agent is originally programmed by its creator to perform a function or to accomplish a task, but is assigned to a particular task by the initiator.", "The creator may be a vendor, or it could be the utility itself.", "The initiator is typically a static agent (or non-human computing entity) operated by a representative of the utility (e.g., an SOI administrator at a substation SOI or feeder SOI).", "In certain implementations, the initiator has access to a library of agents (e.g., stored locally at the computing device implementing the SOI initiator, or stored remotely and remotely accessed) for performing a variety of functions.", "In particular implementations, the initiator acts according to a task list that comprises a set of one or more tasks.", "The task list can be created, updated, or otherwise maintained by an operator of the SOI serviced by the initiator.", "For example, a task at a feeder SOI may be to check power usage to determine whether there is theft of power on that feeder.", "The task list implemented by the initiator may include tasks that need to be performed periodically (e.g., at scheduled intervals).", "Depending on the tasks to be performed by the initiator, a catalog of agents can be stored and accessed by the initiator, the catalog comprising the appropriate set of agents to perform the task.", "3.Exemplary Operations of an Agent To illustrate the operation of an agent, an exemplary scenario in which an agent is dispatched to perform a task on a series of devices within an SOI and returns with collected information to the initiator is described.", "In this representative example, the task is to collect power outputs from photovoltaic panels on a number of houses in a neighborhood (e.g., at 5-minute intervals) within a feeder SOI.", "Additional details concerning exemplary embodiments of the described agent creation process, agent initiation process, agent execution process, and agent authentication and authorization process are discussed in more detail below in Section IV and with respect to FIGS.", "8-12.FIG.", "15 is a schematic block diagram 1500 illustrating the topology and agent movement for the exemplary scenario.", "In particular, FIG.", "15 illustrates a distribution substation 1510 from which the local feeder 1512 originates.", "The feeder 1512 is operative to distribute power among multiple homes, including homes 1520, 1522, and 1524.The distribution substation 1510 further comprises the initiator 1511 for an SOI associated with the feeder (in this example, the feeder SOI comprises the homes 1520, 1522, 1524).", "In this example, the initiator 1511 is communicatively coupled to intelligent sensors associated with photovoltaic panels on each of the homes 1520, 1522, 1524 via network 1514.The network 1514 can be implemented as a Local Area Network (“LAN”) using wired networking (e.g., using the Ethernet IEEE standard 802.3 or other appropriate standard) or wireless networking (e.g.", "using one of the IEEE standards 802.11a, 802.11b, 802.11g, or 802.11n or other appropriate standard).", "Furthermore, at least part of the network 1514 can be the Internet or a similar public network.", "The initiator 1511 and the intelligent sensors at the homes 1520, 1522, 1524 can be implemented using any of the computing devices or computer architectures described above (e.g., general-purpose computing devices or specialized computing devices (such as ASICs or FPGAs)).", "Further, the computing devices can operate using embodiments of the disclosed agent-based software platform.", "In this example, the initiator 1511 at the feeder SOI selects a distributed generation data collection agent to perform the desired task (e.g., an agent for collecting 5-minute power outputs of photovoltaic panels in a neighborhood).", "The code for the agent can be cryptographically signed by its creator at creation time.", "As part of the agent creation, the creator can also define the resources, such as the processing and memory required for the agent to execute the task, and attach the execution requirements to the agent code.", "The execution requirements are sometimes referred to herein as the “resource requirements” or the “agent execution contract proposal.” The initiator 1511 checks the cryptographic signature for the agent either periodically, or during the agent dispatch process.", "In order to dispatch the agent, the initiator 1511 determines the devices on the feeder 1512 (e.g., the intelligent sensors at homes 1520, 1522, 1524) and provides the path information to the agent.", "The determination of the path and the devices on the feeder 1512 can be accomplished by consulting a directory service module.", "The directory service module can retrieve the path information either by an automated discovery process performed by tasking and transmitting a discovery agent, or by consulting a topology and configuration database (assembled, for example, as a result of the earlier use of a discovery agent).", "The initiator 1511 then constructs the agent transport payload.", "In certain exemplary implementations, the agent transport payload comprises the initiator's identification, the creator's identification, the configuration data for the agent (including its path (comprising a list of one or more destination nodes) and task configuration parameters (comprising parameters set by the initiator for the particular task to be performed by the agent), and an empty data container that the agent uses to store its data as it is sent to one or more destination devices (sometimes referred to as the “mutable data container”).", "Note that the data container can grow as the agent performs its task.", "The agent transport payload can also include data identifying the current source (the sending host, which in this case is the initiator node) and, optionally, the next destination host (e.g., the next destination node on the path) of the agent.", "One or more of the components of the agent transport payload can be cryptographically signed by the creator, the initiator, and/or the current host (which may be the initiator).", "For example, a hash of the agent code and/or the creator identification information can be cryptographically signed by the creator.", "Further, the initiator 1511 can cryptographically sign a hash of the combination of configuration data, initiator identification information, creator identification information, and/or agent code.", "Additionally, the source node (or sending node), which for the initial hop is the initiator, can also fill in the source information (and optionally the next destination information) and sign the entire payload with a further cryptographic signature.", "The initiator 1511 then transfers the agent transport payload to a network services interface for transmission on the network 1514 to the first destination (illustrated as first “hop” 1530 to home 1520).", "The network packets may further be protected during transmission by cryptographic means, such as IPsec or SSL.", "The network will transport the agent transport payload to its destination.", "In certain implementations, if the agent transport payload is larger than the maximum transmission unit of the network, the agent transport payload will be fragmented and re-assembled by the network layer.", "At the destination device, the agent transport payload is received and processed.", "In the illustrated example, the destination device is the intelligent sensor at home 1520.For example, the destination device can verify the source and path information by checking the cryptographic signature of the agent transport payload.", "If the payload is not verified, then it will be discarded (and, in certain embodiments, a security violation event is logged).", "If the payload is verified, the agent instantiation process will begin.", "In one exemplary embodiment, the agent instantiation process comprises one or more of the following acts.", "The destination device (which also operates using an agent-based software platform compatible with or the same as the platform used by the initiator) identifies the identity of the initiator (e.g., by parsing the agent transport payload and identifying the identity of the initiator).", "The destination device authenticates the initiator and the source, verifies that the initiator is an authorized initiator for the device's SOI, and verifies that the source of the agent is the prior node in the path.", "The destination device verifies that the configuration data has not been tampered and verifies that the mutable data container was not changed during transport (e.g., by using the one or more hashes sent with the agent transport payload).", "The destination device extracts the agent execution contract template sent with the agent transport payload and verifies that sufficient resources exist to ensure successful execution of the agent.", "If the checks above succeed, the destination device passes executable agent code and data to an agent execution environment associated with the destination device.", "In particular implementations, parts of the agent transport payload signed by the creator and by the initiator are immutable during the movement of an agent.", "Therefore, the associated immutable agent data is desirably preserved to ensure that the agent can move to a next destination device (e.g., a next hop to a next destination node).", "The destination device then executes the agent code so that the agent completes its task on the device and collects the requested information.", "In particular implementations, the collected data is stored in the mutable data container and travels with the agent.", "In certain implementations, the mutable data container is cryptographically signed at each hop by the source (sender) of the agent transport payload.", "Once the requested data is collected and stored at a destination device, the agent will request movement to its next hop based on its path (which can be part of the immutable configuration data in the agent transport payload).", "In the illustrated example, the next hop is second hop 1532 to the home 1522.In certain implementations, the agent transport payload is recreated in the same fashion as when the agent transport payload was created by the initiator, but the mutable data container and the outer parts of the payload are signed by the source device (e.g., the node on the network that is sending the agent to its next destination node).", "At the next destination device (e.g., at home 1522), the process described above will be repeated until all destination devices have been reached.", "For example, in FIG.", "15, a final hop 1534 to home 1524 is illustrated.", "The agent will then be sent back to the initiator.", "For example, in FIG.", "15, a returning hop 1536 from the home 1524 to the initiator 1511 is illustrated.", "When the agent is received by the initiator 1511, the initiator will verify the source, destination, and the mutable data container as described above.", "The initiator 1511 will also verify the remaining immutable segments of the agent transport payload to (once again) confirm that the agent has not mutated during its travels.", "If all of the checks succeed, the initiator will extract the desired information from the mutable data container, thus completing the agent lifecycle.", "4.Agent Movement and Tasking Between SOIs In this section, an exemplary scenario in which a parent SOI tasks an agent to perform a task on a subset of its child SOIs is described.", "In the exemplary scenario, an initiator at a substation SOI dispatches an agent to perform a software update to all devices in a feeder SOI.", "In this case, the initiator will dispatch the software update agent to the initiator of its child SOI using a procedure substantially similar to that described in the previous section (Section III.B.3).", "In this case, however, because the original initiator of the task belongs to a different SOI, the receiving SOI's initiator will check the authentication and authorization of the sending SOI as part of its policy check.", "Additional details concerning exemplary embodiments of the described agent authentication and authorization process are discussed in more detail below at Section IV.D.5 and with respect to FIG.", "12.One exemplary method for authenticating and authorizing the agent comprises the following method acts, which can be performed alone or in various combinations and sub-combinations with one another.", "When the initiator in an SOI receives an agent from another SOI (e.g., from its parent SOI), the initiator authenticates and authorizes the agent as described in the previous section (Section III.B.3).", "This is possible because logically the initiator in an SOI participates in one or more trust relationships with other SOIs.", "Once the agent is authorized, the initiator of the SOI adds an immutable data container that contains the authorization and authentication credentials of the original initiator of the agent.", "The initiator of the SOI can further sign these credentials to ensure that the devices within that SOI will trust the new agent.", "The initiator can then send the agent to the first device on its path using the procedure described above in the previous section (Section III.B.3).", "5.Exemplary Stationary Agent and Agent Upgrade Scenario A stationary agent is an agent that remains on a single device and does not move once deployed.", "Stationary agents can be upgraded by means of pushing new agent code onto the system to replace an existing agent.", "Because the agent in this scenario is stationary, there are times when the agent will need to be upgraded to enhance its functionality or to improve existing functionality.", "Additional details concerning exemplary embodiments of the described agent update process are discussed in more detail below at Section IV.D.4 and with respect to FIG.", "11.One exemplary procedure for upgrading a stationary agent comprises one or more of the following method acts, which can be performed alone or in various combinations and subcombinations with one another.", "The device with the agent being upgraded receives and validates the agent transport payload (e.g., using the process described above in Section III.B.3).", "The agent transport payload is evaluated to determine if it is an upgrade for an existing agent running on the device platform.", "If the payload comprises an update, the currently executing agent is notified that an upgrade is in progress.", "The currently executing agent can then take a snapshot of its state (e.g., by storing information indicative of its current state) and terminate.", "If the currently executing agent does not support upgrade-in-place functionality, then the device platform can terminate the agent.", "The new agent code can then be made available to the agent execution environment, and the agent execution environment will execute the new agent.", "If the agent supports upgrade-in-place functionality, the upgraded agent will restart from its last-saved state; otherwise, the upgraded agent will restart with a clean data store.", "6.Runaway Agent and Reputation-Based Trust Enhancements In certain embodiments of the disclosed software framework, before an agent is instantiated on a platform, the agent presents its “agent execution contract proposal” (discussed above in Section III.B.3).", "The agent execution contract proposal comprises data indicating the execution resource requirements for the agent.", "A resource monitor associated with the device executing the agent can be used to validate the requirements presented by the agent and to generate data indicating that the resources are available on the device, thus “agreeing” to the proposal (this action can be conceptually viewed as the agent creating a binding contract between the platform and the agent).", "The agent (if desired by the creator of the agent) can then monitor the allocated resources.", "If the agent detects a violation of the agreed-upon resource requirements (conceptually, a violation of the contract), the agent can log an event and/or use an interface provided by the resource monitor to trigger a readjustment of the platform resources.", "The resource monitor associated with the device can also monitor the utilization of the platform resources by all agents operating on the platform.", "If the resource monitor detects an agent that is exceeding its agreed-upon resource requirements, the resource monitor can respond.", "For example, in one particular embodiment, an agent can be determined to exceed its resource allocation limit if it exceeds the limit for a set period of time.", "The resource monitor can send the agent a message (e.g., a data message indicating that the agent is in violation of the resource allocation limit) through the platform and to the agent execution environment.", "The resource monitor can then start a timer to track the agent response.", "When the tracking timer expires, and the agent has not responded, the resource monitor will notify the agent execution environment to terminate the agent.", "The resource monitor can then restart the tracking timer.", "If the tracking timer expires and the agent execution environment has not responded, the resource monitor can terminate the agent through operating system level mechanisms (e.g., a “force quit” mechanism).", "One possible advantage of having control over the trust mechanisms in the agent-based software platform is that reputation-based schemes can be utilized to propagate information about unreliable or faulty agents within an SOI or through the entire system.", "For example, if an agent repeatedly fails to honor the agent execution contract, due to malicious intent or a software bug, this information can be sent back to the initiator of the SOI.", "The initiator can then stop tasking this agent, and the information can also be sent back to the creator of the agent as well.", "C. Capabilities of and Considerations for Embodiments of the Disclosed Software Platform This section describes some of the capabilities that can be realized in embodiments of the disclosed technology and also describes some of the hardware, software, and networking considerations that are involved in implementations of the disclosed technology.", "Although some of these functions and/or capabilities may not be feasible for some devices in the power system, the examples described below illustrate possible functions and capabilities that can be realized using embodiments of the disclosed technology.", "Additionally, due to long equipment replacement cycles in the power industry, it may not be feasible to upgrade all older equipment quickly to enable some or all of the described functionality.", "To help accelerate the deployment of intelligent sensors in the power grid and to help realize at least some of the described functionality, one or more proxy devices can be coupled between legacy devices (e.g., legacy sensors) and control applications in order to provide at least some of the enhanced functionality described.", "This proxy device is sometimes referred to herein as an “intelligent sensor aggregator” (“ISAg”).", "1.Hardware In order for embodiments of the disclosed technology to be flexible and capable of implementation across a wide variety of hardware platforms, the hardware requirements for the software platform used to implement the representative framework are desirably not highly demanding.", "Even so, there may be instances of legacy hardware that are not capable of running the software platform for the representative framework.", "For devices that are not capable of accommodating the agents, an ISAg device can act as a proxy platform and still enable the desired functionality that is required.", "The hardware used to implement embodiments of the disclosed software platform (e.g., the hardware used at sensors or controllers in the power system) can be separated into the central processing unit (“CPU”), memory, storage, and inputs/outputs.", "For CPUs, and according to one exemplary embodiment, a memory management unit (“MMU”) that supports virtual memory, paging, and process memory segmentation is used.", "These MMU capabilities are not very strict, since in the last several years embedded microprocessors from many CPU families (e.g., ARM, PPC, x86) have all gained an MMU.", "One benefit of an MMU in an embedded device is the ability to support memory isolation and segmentation between different processes running on the CPU.", "This enables different agents running on the system to be isolated from each other and improves the cyber security of the platform.", "The memory (e.g., RAM) located on a device used in the power system can be relatively small compared to what is commonly used in consumer applications.", "For instance, in some non-limiting examples, devices with 256 MB or more memory can be used, although embodiments of the disclosed software platform can be sized down to lower memory sizes as well.", "Further, in certain non-limiting exemplary embodiments, the devices have at least 128 MB of non-volatile storage, though the embodiments of the disclosed platform can operate using devices with less storage as well.", "Typically, in control systems, flash memory is used and the operating system is aware of wear associated with flash memory when information is written to the same sectors repeatedly.", "A sensor or controller can have many inputs and outputs.", "Embodiments of the disclosed software platform can be used with sensors or controllers having any number inputs and outputs.", "An ISAg can have many serial and networked inputs.", "Since the sensors or controllers are assumed to be networked, the sensors or controllers used with the disclosed software platform will typically have at least one wired or wireless network interface.", "2.Operating System Embodiments of the disclosed software platform can operate using a wide variety of operating systems.", "For example, in particular non-limiting examples, and given the memory, storage, and CPU capabilities of devices that are present in the power system, the operating system is desirably capable of running on devices with a memory of 256 MB or more and reserves 128 MB or more of memory for the agent framework for agents.", "In other embodiments, the operating system is implemented on devices with less memory.", "3.Diagnostic and Manageability Considerations Embodiments of the disclosed software framework allow for improved diagnostics and management.", "For example, agents can be dispatched to collect data as they move through the system and can then carry that data back to a management station.", "Embodiments of the disclosed software platform are capable of managing the activities of multiple hosted agents (e.g., all hosted agents) in the system.", "This management function can include, for instance, stopping, restarting, or banning any agent deployed in the system.", "4.Information Sharing In certain embodiments of the disclosed software platform, the agents used in the power grid are capable of accomplishing tasks that would normally require large amounts of communication if implementing using a centralized system.", "In order to limit the amount of information being communicated across wide portions of the system, “scopes of influence,” as introduced above, are used to create communication boundaries between groups of sensors and their associated agent initiators.", "Further, the communications that occur in such a “scope of influence” are secure and reliable.", "In certain embodiments, the sensors and/or controllers may be further divided into sub-groups (sometimes referred to as “task groups”) that are task based.", "For example, sensors and/or controllers collaborating on accomplishing load sequencing may belong to a “load sequencing” task group.", "An example method of performing load sequencing is described below with respect to FIGS.", "13A-B.", "5.Runtime Environment As noted above, the software agents used in embodiments of the disclosed software framework can be stationary or roam between sensors and/or controllers in the system.", "Agents are task driven and can be used to accomplish a task that involves many sensors and/or controllers.", "Certain embodiments of the disclosed technology exhibit one or more of the following features: (1) agents are capable of running on multiple CPU architectures as long as agent resource requirements are met (the agents operate with a runtime environment that is independent of the underlying CPU architecture); (2) the agent framework is able to determine whether it has the capabilities to support a particular agent; (3) the agent framework is able to determine if the agent requesting “hosting” is authorized to execute on that platform; (4) the agent framework is able to determine if the agent code has been tampered with; (5) the agent framework allows agents to store information on-board; (6) the agent framework provides access to information collection and dissemination services for the agent; (7) the agent framework is able to allocate (e.g., stochastically) a requested slice of its resources such as memory, storage, processor cycles to an agent; (8) the agent framework is able to detect and terminate an agent that is not behaving according to its agent/platform contract; (9) the agent framework is able to collect and transmit an inventory of agents hosted by the platform; (10) the agent framework can implement a “liveness” check for each agent hosted on the platform in order to detect and terminate malfunctioning agents; and/or (11) the agent framework can provide a protected environment for each agent (e.g., including memory and storage protection).", "6.Configuring, Changing, and Updating Agents Embodiments of the disclosed software platform allow for agents to be easily configured, changed, and updated.", "For example, if smart meter data collection is implemented as an agent, the metrology agent can be updated using embodiments of the disclosed technology without needing to perform a costly and time consuming monolithic firmware upgrade for the entire platform image.", "A new version of an agent can simply be dispatched by means of an update agent that moves through the system.", "An update agent can also perform configuration and change management duties.", "To enable such functionality, embodiments of the disclosed software platform use a well-defined interface for agents such that an agent can be upgraded without needing a complete software update for the entire platform.", "7.Security and Robustness The sensors and controllers in a power system are networked devices.", "In order to allow the sensors and controllers in the system to be able to share information securely, certain embodiments of the disclosed agent-based software framework exhibit one or more of the following features: (1) the agent framework validates agent software as part of the instantiation process; (2) the agent framework periodically validates the software to detect tampered executables if the software framework resides in modifiable storage; (3) the agent framework locks certain memory locations as read-only once the boot process is completed (this may include all cryptographic and authentication libraries and be performed using capabilities in the operating system); (4) the agent framework detects resource exhaustion (either malicious or due to defective software) and take corrective action; (5) for battery operated platforms, the software platform detects behavior that causes battery exhaustion and take corrective action; (6) the agent framework is resilient against misfiring interrupts and can mask a misfiring interrupt (e.g., using interrupt handling mechanisms in the operating system); and/or (7) the agent framework offers memory protection to hosted agents (e.g., using memory protection capabilities in the operating system).", "Additionally, in certain implementations of the disclosed technology, the networked devices desirably handle incoming network traffic at the full data rate supported by their interfaces.", "For example, a sensor that has a 100 Mbps IEEE 802.3 Ethernet interface desirably receives packets at or near that full rate without crashing or hanging.", "Further, the device hardware used in certain embodiments of the disclosed technology includes interfaces that communicate with the agent framework and are used to implement a physical tamper detection warning system that generates an event when physical tampering is detected by tamper detection circuitry.", "Additionally, some embodiments of the disclosed technology are adapted to satisfy the authentication, authorization, and accounting (“AAA”) requirements as discussed in Stouffer, K., et al., “Guide to Industrial Control Systems (‘ICS’) Security, Technical Report Special Publication,” NIST, 800-82 (2008), as well as requirements for communication protocols security.", "Additional cyber security requirements that can be met in certain embodiments can be found in Smart Grid Interoperability Panel Cyber Security Working Group, “Guidelines for Smart Grid Cyber Security,” NIST IR 7628 (2010).", "IV.", "Detailed Description of Exemplary Software Frameworks and Methods for Using Agents A. Overview of Software Platform Components FIG.", "3 is a schematic block diagram 300 showing a generalized view of a hardware/software framework 310 that can be used in embodiments of the disclosed technology.", "In particular, the framework 310 can be used to implement any of the intelligent sensors, controllers, and/or initiators in the system.", "In particular, the framework 310 comprises a base hardware platform 312 that comprises the hardware resources for implementing the software platform and is further coupled to digital and/or analog sensing/control interfaces 314 (e.g., for receiving data sensed at the sensor) and network communication interfaces 316 (e.g., for communicating with the initiator and sensors in the network).", "An operating system 320 is optional, as certain runtime environments can run directly on hardware without the need of an operating system.", "Agent framework 330 is executed on the base hardware platform 312 (optionally in conjunction with the operating system 320).", "The agent framework 330 is the main runtime environment for the agents.", "Exemplary embodiments of the agent framework 330 are described below as framework 400 and framework 500.One or more agent applications (such as applications 332, 334) run using the agent framework 330.In particular embodiments, other applications 336 can also be executed on the base hardware platform 312.FIG.", "4 is a schematic block diagram showing internal components of an exemplary intelligent sensor or controller agent framework 400.The framework 400 can be used as the agent framework 330 in FIG.", "3.The schematic block diagram of FIG.", "4 illustrates the components as a series of layers.", "At the base layer, a hardware direct interface 410 allows the framework to run directly on top of hardware, and an operating system interface 412 allows the framework to operate as a module inside an operating system.", "Agent network communication layer 420 provides a network communication interface, including the necessary cyber security functions for data transport.", "Agent discovery, cooperation, and collaboration layer 430 allows the agents executing in the framework 400 to discover other agents, exchange information securely, and cooperate to accomplish tasks.", "Agent authentication and authorization layer 440 validates that an agent is authorized to execute on the sensor or controller and that the agent has not been tampered with during transit.", "In particular embodiments, the authentication and authorization of the agent is performed by consulting with a resource scheduling and guarantees layer 450.The resource scheduling and guarantees layer 450 determines whether the platform has sufficient resources to accommodate this agent.", "Agent instantiation and mobility layer 460 supports movement of agents between devices.", "Agent execution environment 470 provides all other services that allow an agent to accomplish its tasks.", "One or more agent applications (such as agent applications 480, 482) operate in the agent execution environment 470.FIG.", "5 is another schematic block diagram showing internal modules of an exemplary intelligent sensor or controller agent framework 500.The modules illustrated in framework 500 serve to implement the functionality of the layers illustrated in framework 400.The modules in FIG.", "5 can be categorized as either external facing (interfacing with components outside of the framework), related to security, related to agent support, or related to agent execution.", "In particular embodiments, authentication and authorization module 510, trust store module 512, and configuration policies module 514 represent the security-related modules.", "Network services interface 532 and resource monitor module 530 represent external facing components.", "Directory services module 520, agent packaging and instantiation module 522, information exchange bus 524, and local store 526 represent agent support modules.", "Agent execution environment 540 and its sub-components represent modules related to agent execution.", "In certain exemplary embodiments, the authentication and authorization module 510 validates that an agent is authorized to execute on the device and that the agent has not been tampered with during transit.", "The agent can be authenticated, for example, using a public key pair (e.g., an X.509 public key pair).", "For instance, in particular embodiments, SOI administrators, initiators, and creators each have a public key.", "In certain implementations, the possible hosts in the system also have respective public keys.", "Further, the public keys can be stored in the SOI-level trust store module 512.The trust store module 512 can operate as a whitelist, meaning that keys will only be present for entities for which interaction is approved by the SOI administrator.", "The public keys can also be marked for expiration.", "In certain embodiments, possible hosts in the system (e.g, all possible hosts across the system or in the local SOI) are stored in a directory service module 520, which can be accessed by the authentication and authorization module 510.Further, in particular embodiments, the SOI administrator can store an authoritative policy (e.g., describing all authorized agent interactions) as part of the configuration policies module 514.In certain exemplary embodiments, the trust store module 512 interacts with an SOI administrator in the following manner.", "If a public key for an SOI administrator, agent initiator, agent creator, or other entity to be verified cannot be found in the local trust store (e.g., in the trust store module 152), then a request to the SOI administrator is made to retrieve it.", "If the public key is not in the SOI administrator's trust store, the SOI administrator requests it from one or more of its peer SOI administrators, a utility company having authority over the SOI administrator, and/or a balancing authority with certificate authority.", "An agent initiator can be given the SOI administrator's public key upon startup, and the local SOI administrator is trusted once authenticated.", "During agent instantiation (performed by agent packaging and instantiation module 522), the authorization and authentication module 510 performs one or more of the following services: (1) verifying that the configuration data has not been tampered with; (2) verifying that the mutable data container has not been changed during transport; (3) verifying that the immutable container (including the agent code) has not changed during transport or prior execution; (4) if the SOI of the agent is not the local SOI, verifying the identity, reputation, and authorization of the SOI administrator (e.g., by checking whether the SOI administrator signature matches a public key in a local cache (such as a local trust store 512), checking whether the SOI administrator is trustworthy (by checking data stored in the local trust store 512), and/or checking whether the SOI administrator's agents are allowed to be considered for running in the local SOI (by checking data stored in the local trust store 512); (5) verifying the identity, reputation, and authorization of the agent initiator (e.g., by checking whether the agent initiator signature matches a public key in a local cache (such as the trust store 512), checking whether the agent initiator is authorized to dispatch an agent to the device (by checking data stored in the local trust store 512), and/or checking whether the agent initiator is trustworthy (by checking data stored in the local trust store 512)); (6) verifying the identity, reputation, and authorization of the creator (e.g., by checking whether the agent creator signature matches a public key in a local cache (such as the trust store 512), checking whether the agent creator is authorized to create agents of this type (by checking data stored in the local trust store 512), and/or checking whether the agent creator is trustworthy (by checking data stored in the local trust store 512)); (7) verifying the authorization of the agent (e.g., by verifying that agents of this type are allowed to run within this SOI by checking the configuration policy to determine whether the policy (a) permits the desired agent execution; (b) permits the desired agent execution from the SOI from which the agent was sent; (c) permits the desired communication with other agents, if any, in the SOI; and/or (d) permits the desired communication with other agents, if any, in other SOIs).", "During agent tasking, the authorization and authentication module 510 performs one or more of the following services: (1) verifying the cryptographic signature; and/or (2) checking the reputation of hosts on the proposed agent path.", "Once agent tasking is complete, the authorization and authentication module 510 can also update reputation data for hosts, initiators, and SOIs.", "The authorization and authentication module 510 can perform its function using a wide variety of security technologies (e.g., the Cryptographic Trust Management system available from Pacific Northwest National Laboratories (see, e.g., T. W. Edgar, “Cryptographic Trust Management Requirements Specification,” version 1.1, PNNL-18744 (September 2009)), X.509 certificates, SAML, IPsec, PGP, and the like), trust technologies (e.g., reputation tracking and trust negotiation technologies), and/or policy languages and technologies (e.g., XACML and SPARQL).", "Example encryption technologies that can be used by the authorization and authentication module include RSA, ECC, AES, and/or PGP.", "In certain exemplary embodiments, the configuration policies module 514 is operable to store the policies for what agents are allowed to do at the particular intelligent sensor or controller implementing the framework 500 and to store the allowable actions of the framework 500.The policies for what agents are allowed to do can be based on the reputation of the agent and/or the sensitivity of controls available at the intelligent sensor or controller.", "In certain embodiments, the configuration policies modules 514 can be called by, for example, the authorization and authentication module 510 and the agent packaging and instantiation module 522 to determine if an agent has permission to perform desired actions.", "In certain exemplary embodiments, the agent packaging and instantiation module 522 is operable to allow a message body to be passed to the agent execution mechanism of each agent environment in the agent execution environment 540.For agents moving between platforms, the agent packaging and instantiation module 522 can intercept the normal mechanism, packaging the agent up instead of allowing it to move on its own.", "In certain embodiments, the agent packaging and instantiation module 522 is called by the agent execution environment 540 through information exchange bus 524 when an agent is ready to be sent from the framework 500 to it next destination node.", "The network services interface 532 can also send messages from other platforms to the agent packaging and instantiation module 522 for agents moving onto the framework 500.In certain exemplary embodiments, the information exchange bus 524 serves as the agent execution environment interface and is operable to: (1) allow agents in different environments (e.g., a Python agent environment 542, a JAVA agent environment 544 (such as JADE (Java Agent Development Framework), and/or a binary agent environment 546) to communicate with each other; (2) allow agents to communicate with agents on other platforms; (3) allow the framework 500 to communicate with its agents; and/or (4) receive information from resource monitor 530 indicating that a misbehaving agent in one of the environments is to be shut down.", "In certain embodiments, the information exchange bus 524 can be called by the agent packaging and instantiation module 522, the network services interface 532 (which can send put messages for receipt by the packaging and instantiation module 522), the resource monitor 530 (which can send shutdown notice for the agent execution environment 540), and/or the agent execution environment 540 (which can send messages for other agent or mobility requests).", "In certain exemplary embodiments, the resource monitor module 530 is operable to: (1) help ensure that agent threads do not consume more resources than their contract asked for; (2) shut down misbehaving threads; and (3) utilize operating system level thread monitoring and control.", "In particular embodiments, the resource monitor module 530 is called by the agent packaging and instantiation module 522 (which can send messages to the resource monitor module 530 to determine if there are sufficient resources to satisfy an agent contract) and calls into the information exchange bus 524 to shutdown an agent consuming too many resources.", "In certain exemplary embodiments, the local data store module 526 is operable to store local information both about the framework 500 (e.g., which operates as a node in the power system) and persistent information from agents running at the node.", "In particular embodiments, the local data store module is called by the information exchange bus 524 when an agent wants to store or read longer term information and/or any other module in the framework 500 requesting data to be stored.", "In certain exemplary embodiments, the directory services module 520 is operable to maintain a list of other platforms, agents, and agents by service provided.", "In particular embodiments, the directory services module 520 is called by the agent packaging and instantiation module 522 in order to look up the location of a node an agent wishes to move onto or of a node to which an agent wishes to deliver a message.", "In certain exemplary embodiments, the network services interface 532 is operable to receive information that comes in from the network and route the information to the information exchange bus 524.The network can be implemented as a Local Area Network (“LAN”) using wired networking (e.g., using the Ethernet IEEE standard 802.3 or other appropriate standard) or wireless networking (e.g.", "using one of the IEEE standards 802.11a, 802.11b, 802.11g, or 802.11n or other appropriate standard).", "Furthermore, at least part of the network can be the Internet or a similar public network.", "In particular embodiments, the network services interface 532 is called by an external application or platform (e.g., another node in the system operating with its own instance of framework 500).", "The network services interface can call into information exchange bus 524 (to send message to be picked up by the agent packaging and instantiation module 522).", "In certain exemplary embodiments, agent execution environment 540 is operable to provide one or more specific execution environments in which an agent will run (e.g., a Python agent environment 542, a JAVA agent environment 544 (such as a JADE (Java Agent Development Framework), binary environment 546, and/or any other agent environment (such as JINI, Cougaar, Lua, C++, Squawk, and the like).", "This allows agents written in different languages to be executed using embodiments of the disclosed software platform.", "Further, the agents can be written in their native language and do not require any translation to a common agent environment.", "The agent execution environment 540 can be implemented in part as a plugin or daemon that subscribes to agent instantiation requests from the agent packaging and instantiation module 522 via the information exchange bus 524 (e.g., on receiving a request, the agent execution environment 540 can create an instance of the environment for that agent or add that agent to an existing, compatible environment).", "In particular embodiments, the agent execution environment 540 is called by the agent packaging and instantiation module 522 via the information exchange bus 524.The agent execution environment 540 can be controlled by components in the agent packaging and instantiation module 522.For example, an agent execution environment manager (“AEE manager”) can be part of the agent packaging and instantiation module 522.After validation and resource checking has been completed by the agent packaging and instantiation module 522, the AEE manager can determine the agent execution environment needed by the agent.", "For example, for a JADE agent, the AEE manager can: (1) create a JADE main container; (2) create a JADE manager class which creates the main container; and/or (3) publish a message that an agent wants to move onto the JADE AEE.", "The JADE main controller is operable to listen for JADE agent requests.", "When a JADE agent request is received, if no main container has been created, the JADE manager can create one.", "In order to maintain control, the main container is desirably not a separate process.", "In particular implementations, the JADE main container is part of and started by the JADE controller.", "Further JADE containers can join the JADE platform maintained by this main container.", "In general, a JADE container is created as a place for JADE agents to reside and can be started as a separate process for agents moving onto the platform.", "The JADE container can point to the main container.", "In some implementations, however, outside agents are not run on the main container in case they need to be terminated.", "B. Overview of Components of the Agent Transport Payload FIG.", "6 is a schematic block diagram illustrating the agent transport payload 600 (e.g., the data that is transported with an agent) for an exemplary agent implemented according to the disclosed technology.", "Agent transport payload 600 includes destination identification data 610, source identification data 612, initiator identification data 614, creator identification data 616, agent code 618, immutable data 620 (sometimes referred to as “immutable luggage”), mutable data 622 (sometimes referred to as “mutable luggage”), validation payload data 624, and execution contract data 626.In particular embodiments, one or more of the data components of the payload 600 (alone or in any combination with one another) are signed by the entity that was responsible for the data.", "For instance, in particular embodiments, the destination identification data 610, source identification data 612, and mutable data 622 are signed by the most recent host (or node) that handled the agent transport payload 600 and forwarded it to the current host; the initiator identification data 614, the validation payload data 624, and the execution contract data 626 are signed by the initiator (e.g., the initiator node that originally assigned and transmitted the agent onto the network); and the creator identification data 616 and the agent code data 618 are signed by the creator (e.g., the entity that originally created the agent, such as the utility or utility vendor).", "Hashes for one or more of the data components are also included as part of the cryptographic signatures in the agent transport payload 600.In the illustrated embodiment, the destination identification data 610 comprises data identifying the node the agent is moving onto.", "The source identification data 612 comprises data identifying the node the agent is moved from.", "The initiator identification data 614 comprises data identifying the host (or node) that instantiated the agent.", "In general, the initiator is responsible for setting the available task configuration parameters for the agent, but does not modify the original code of the agent.", "The creator identification data 616 comprises data for identifying the entity that created the agent (e.g., the entity that wrote the original code for the agent, which is typically the utility or a vendor for the utility).", "The creator typically does not instantiate the agent (e.g., by setting its configuration parameters, setting its delivery paths, and sending the agent) but instead writes the original code for the agent, which is then used by initiators in the network.", "The agent code 618 comprises the executable code that when executed performs the desired task for the agent (e.g., the data comprises the actual byte code for the agent that is executed, for instance, by the agent execution environment of the platform).", "The immutable data 620 comprises any task configuration parameters that are used to instantiate and properly run the agent (e.g., the agent path, initial data, initial payloads, and the like).", "The data is termed “immutable” because it does not (or cannot) change during the lifecycle of the agent.", "Further, the data container for the immutable data 620 can be referred to as the immutable data container.", "The mutable data 622 comprises current state, data, or payloads that the agent uses to perform its task.", "The data is termed “mutable” because it can be changed and is typically changed at every node at which the agent stops.", "Further, the data container for the mutable data 622 can be referred to as the mutable data container.", "The validation payload data 624 comprises data that is used to validate that the agent is authentic and authorized to perform its desired actions.", "The validation payload 624 can include a code checksum, credentials, hashes, and the like.", "The execution contract data 626 comprises data indicating the “contract” the agent makes with the platform it is moving onto.", "More specifically, this data can include an identification of the resources (e.g., memory and CPU) required to execute and the actions it wishes to perform.", "Furthermore, in certain implementations and even though the creator initially defines the resource requirements, the initiator confirms the resource requirements needed and modifies them as necessary when it sets the configuration parameters for the agent.", "In use, the resource components of the execution contract data 626 can be used by the resource monitor (e.g., resource monitor module 530) while the actions component can be used by the configuration policy module (e.g., configuration policy module 514).", "C. Agent Operation Overview FIG.", "7 is a schematic block diagram illustrating an exemplary method of creating, tasking, and dispatching an agent.", "The method acts illustrated in FIG.", "7 can be performed by a single entity (e.g., using a single computer) or by multiple different entities (e.g., a creator 720 that is separate from the initiator 722, as illustrated).", "At 710, an agent is created.", "For example, the executable agent code can be written and signed by a creator 720.The execution requirements for executing the agent code can also be determined at this time and stored as part of the agent (e.g., as part of the execution contract data 626 of the agent transport payload 600).", "At 712, the agent is tasked.", "For example, the agent can be selected by an initiator 722 to perform the task for which its agent code is written.", "The agent code may be stored locally at the initiator or in a remote server (such as a central server on the network).", "The configuration parameters for the agent and the path for the agent (e.g., the identity of the nodes on the network that the agent is to be sent to) can be determined and set as part of tasking the agent at 712.This information is typically stored as immutable data (e.g., immutable data 620 stored in an “immutable data container”) and signed by the initiator.", "At 714, the agent is sent to its destination.", "For example, the agent (e.g., comprising the agent transport payload 600) is transmitted on a network through a network services interface to a destination node (which may be the first of several destination nodes for the agent).", "D. Exemplary Operations for Creating, Instantiating, and Upgrading Agents This section introduce more detailed embodiments of performing agent-related actions, including agent creation, agent initiation, agent execution, agent upgrade, and agent validation.", "1.Agent Creation FIG.", "8 is a flow chart showing an exemplary technique 800 for creating an agent.", "Typically, the technique 800 is performed by a vendor or utility.", "At 810, an agent type is defined.", "An agent can belong to one of multiple agent types.", "Agent types can be categorized based on the type of task performed, the network in which the agent operates, or other such bases.", "The agent type can be included as part of the data in the agent transport payload (e.g., as part of the agent code data 618 or the execution contract data 626).", "At 812, the agent actions are defined.", "For example, the desired agent actions can be written as code that is executable in an agent execution environment and that causes the processor implementing the platform to perform the desired task.", "For example, the agent may be used to obtain data from sensors at the node, control one or more operations at the node (e.g., based on the sensed data), or to perform other such tasks.", "Exemplary tasks and actions that can be performed by agents are described in more detail below in Section V. The agent type can be included as part of the data in the agent transport payload (e.g., as part of the agent code data 618).", "At 814, resource requirements for performing the agent action are defined.", "The resource requirements can be determined by simulations of the agent actions, emulations of the agent actions, an analysis of the operations used to perform the desired agent actions and associated memory requirements, or any other suitable mechanism.", "In particular embodiments, the resource requirements are defined as part of the execution contract data (e.g., execution contract data 626) of the agent transport payload.", "At 816, a cryptographic hash of the portion of the payload created by the creator is signed with the creator's private key.", "The creator's asymmetric key pair can be X.509 or PGP, for example, and can be managed using the Cryptographic Trust Management system available from Pacific Northwest National Laboratories.", "Example encryption technologies include RSA, ECC, AES, and/or PGP.", "At 818, the new agent (along with its creator signature) is stored (e.g., on one or more computer-readable storage media).", "The new agent can be transmitted to administrators in the network and stored locally or can be stored at locations that are accessed remotely by administrators in the network.", "In particular implementations, the agent creation procedure 800 makes calls into one or more of an agent type list, an agent action list, a resource list, and/or an agent signing API.", "2.Agent Initiation FIG.", "9A is a flow chart showing an exemplary technique 900 for initiating (or instantiating) an agent.", "Typically, the technique 900 is performed by an SOI administrator.", "At 910, an agent is received.", "For instance, an uninitiated agent for performing a particular task can be loaded by an initiator (e.g., buffered into memory, loaded, or otherwise accessed for further processing).", "Or, an agent from another SOI can be received at a network services interface and loaded at a node in a local SOI.", "At 912, a determination is made as to whether the creator signature is valid.", "For example, the creator's signed hash can be verified by the initiator using the creator's public key and the resulting hash can be compared to a hash of the creator-specific code generated by the initiator.", "In particular implementations, the signature is verified using the Cryptographic Trust Management system available from Pacific Northwest National Laboratories, X.509 certificates, or any other suitable signature encryption/decryption technique.", "If the creator signature is not valid, then the agent is discarded at 914; otherwise, the technique continues to 916.At 916, a determination is made as to whether the agent is from another SOI.", "This determination can be made, for example, by checking the initiator data in the agent transport payload of the agent.", "If the agent is from another SOI, then the SOI is authenticated and authorized at 918.In particular embodiments, the SOI is authenticated and authorized by performing the method 1200 shown in FIG.", "12 or by matching the initiating SOI to a list of authorized SOIs (e.g., stored in the trust store 512).", "If the agent is authorized, then additional trust information is added to the immutable data at 920.For example, information that approves the agent for use in the local SOI is added.", "If the agent is not from another SOI, then the technique 900 proceeds at 922.At 922, the path for the agent is determined.", "For example, if the agent is being used to obtain information from a particular node or to control operation at a particular node, the path (e.g., the identity or network address for the node) can be determined.", "Or, if the agent is to be sent to multiple nodes, a list of the multiple nodes (e.g., the identities or network addresses for the multiple nodes) can be determined.", "This information can be determined, for instance, by accessing a directory service module (e.g., the directory service module 520, which comprises network identification information for the nodes in the network).", "At 924, the agent transport payload is constructed and stored.", "For example, one or more of the initiator data 614, the immutable data 620 (including the agent path and the executable code for performing the desired task for the agent), the validation payload data 624, or the execution contract data 626 are set.", "Further, the destination data 610, the source data 612, and/or the mutable data 622 can be set.", "Any one or more of these data components or combinations thereof can be signed by the initiator.", "At 926, with the agent transport payload constructed, the agent is transmitted to the one or more destination nodes on its agent path (e.g., via the network services interface 532).", "FIG.", "9B is a flow chart showing an exemplary technique 950 for receiving an agent (e.g., a returning agent after being transmitted using technique 900, or any other agent) At 960, the agent is received (e.g., buffered, loaded into memory, or otherwise accessed for further processing).", "For example, the agent can be loaded via the network services interface 532.At 962, a determination is made as to whether the agent code has been tampered with.", "For example, a cryptographic signature sent with the agent transport payload can be checked and verified (e.g., using any of the encryption/decryption techniques mentioned above and using data stored in the trust store 512).", "In particular embodiments, a hash of the agent code can be computed and compared to a signed hash for the agent code sent with the agent transport payload.", "The hash for the agent code can be signed by one or more of the previous host (e.g., the sender), the initiator, or the creator, and can be decrypted using the public keys for these entities.", "The signed hash for any one or more (or all) of the sender, the initiator, or the creator can be used to verify the integrity of the agent code.", "For example, only a hash signed by the creator can be used to verify the agent code.", "If the agent code is not valid, the agent is discarded at 964; if the agent code is valid, the technique 900 continues at 966.At 966, a determination is made as to whether the identity of the initiator is valid.", "For instance, the trust store 512 can be checked to determine whether the identity of the agent's initiator matches an initiator in the trust store.", "If the initiator identity is not valid, the agent is discarded at 968; if the initiator identity is valid, the technique 900 continues at 970.At 970, a determination is made as to whether the initiator is authorized to dispatch an agent to the host and whether the SOI of the initiator matches the SOI of the device.", "For instance, the trust store 512 can be checked to determine whether the agent's initiator is an authorized initiator.", "If the initiator is not authorized, the agent is discarded at 972; if the initiator is authorized, the technique 900 continues at 974.At 974, a determination is made as to whether the immutable data is authentic.", "For instance, a hash of the immutable data can be computed and compared to a signed hash for the immutable data sent with the agent transport payload.", "The hash for the immutable data can be signed by one or more of the previous host (e.g., the sender), the initiator, or the creator, and can be decrypted using the public keys for these entities.", "The signed hash for any one or more (or all) of the sender, the initiator, or the creator can be used to authenticate the immutable data.", "For example, only a hash signed by the initiator can be used to verify the immutable data.", "If the immutable data is not authentic, the agent is discarded at 976; if the immutable data is authentic, the technique 900 continues at 980.At 980, a determination is made as to whether the mutable data is authentic.", "For example, a hash of the mutable data can be computed and compared to a hash sent with the agent transport payload.", "For example, the hash for the mutable data can be signed by the previous host (e.g., the sender) and can be decrypted using the public key for the sender.", "If the mutable data is not authentic, the agent is discarded at 982; if the mutable data is authentic, the technique 900 continues at 984.At 984, data is extracted from the agent.", "For example, data is parsed and extracted from the agent transport payload.", "In particular implementations, the agent creation procedure 900 can be called by calls through the network (e.g., network services interface 532) and can makes calls into one or more of the agent packaging and instantiation module 522, the authentication and authorization module 510, the directory service module 520, and/or the local store 526.3.Agent Execution FIG.", "10A is a flow chart showing an exemplary process 1000 for executing an agent.", "Typically, the process 1000 is performed by a host on the network (e.g., an intelligent sensor or intelligent controller (or other node on the network) that includes computing hardware for implementing the agent-based software platform (e.g., the software platform 500)).", "In general, the agent execution process 1000 includes a set of tasks which first verifies the authorization and authenticity of the agent prior to actual execution.", "Once execution has been competed, data is collected, a new path is selected, the agent payload is reconstructed, and the agent moves to another device.", "At 1010, an agent is received at the current host.", "For instance, the host can receive the agent transport payload for the agent over a network (e.g., via network services interface 532) and identify the host as its destination (e.g., from the destination data 610).", "The agent transport payload can then be loaded by the host (e.g., buffered into memory, loaded, or otherwise accessed for further processing).", "At 1012, the agent is validated using an authentication and authorization process (e.g., the authentication and authorization process 1200 shown in FIG.", "12 and discussed below).", "At 1014, a determination is made as to whether the agent is an agent upgrade.", "If so, then an agent upgrade process is performed at 1016 (e.g., the agent upgrade process shown in FIG.", "11); otherwise, the process proceeds to 1018.At 1018, the agent code is executed, resulting in the agent performing its intended task.", "For example, in particular embodiments, the agent code data 618 can be parsed from the agent transport payload and executed in the appropriate agent execution environment (e.g., agent execution environment 540).", "FIG.", "10B is a flow chart showing an exemplary technique 1050 for processing an agent that has completed its task.", "Typically, the technique 1050 is performed by the same host on the network that received the agent and initiated its execution.", "At 1060, an indication that the agent has completed its task is received (e.g., a flag, variable, or other parameter is set).", "At 1062, information related to the performance of the task is collected.", "For instance, the data requested by the agent may be stored in a certain file or memory location, which is accessed so that the data can be loaded and stored as part of the mutable data 622 in the agent transport payload.", "At 1064, the path for the agent is determined.", "This information can be determined, for instance, by accessing the immutable data (which lists the destination node(s) for the agent) and/or accessing a directory service module (e.g., the directory service module 520, which comprises network identification information for the nodes in the network).", "At 1066, the agent transport payload is constructed and stored.", "For example, the mutable data (e.g., the mutable data 622) can be updated to include the information collected at 1062.Further, the current host can sign the mutable data with a cryptographic signature At 1068, with the updated agent transport payload constructed, the agent is transmitted (e.g., via the network services interface 532) to the next destination node on its agent path (or back to the initiator if there are no further destination nodes).", "In particular embodiments, the agent execution process is called by the network module (e.g., network services interface 532) when an agent arrives at the host (or node) of the network.", "The agent execution process can call into one or more of a validation and authentication process (e.g., authentication and authorization process 1200 shown in FIG.", "12), agent upgrade process (e.g., agent upgrade process 1100 shown in FIG.", "11), agent execution process (e.g., an execute agent process performed by the agent execution environment 540), network process (e.g., a process for moving the agent to a next device performed by the network module 532), information exchange bus (e.g., a process for collecting data performed by the information exchange bus 524), directory services process (e.g., a process for selecting a new device performed by the directory service module 520), and/or payload construction process (e.g., a process for payload construction performed by agent packaging and instantiation module 522).", "4.Agent Upgrade FIG.", "11 is a flow chart showing an exemplary process 1100 for upgrading an agent.", "Typically, the process 1100 is performed by a host on the network (e.g., an intelligent sensor or intelligent controller (or other node on the network) that includes computing hardware for implementing the agent-based software platform (e.g., the software platform 500)).", "In particular implementations, this is a common module for all platforms and checks for an upgrade agent.", "If the agent is authentic and authorized, this process then upgrades the agent.", "At 1110, a determination is made as to whether the agent upgrade is for an agent on the current host.", "If the upgrade agent is not for an agent on the current host, then the agent upgrade is discarded at 1112; if the upgrade agent is for an agent on the current host, then the process proceeds at 1114.At 1114, a snapshot of the state of the agent is made (e.g., by storing information indicative of the current state of the agent, which may be currently executing).", "The agent can then terminate.", "At 1116, a determination is made as to whether the agent has terminated.", "An agent that does not support upgrade-in-place functionality, for example, may not terminate.", "If the agent has not terminated, then the agent is forcibly terminated at 1118 (e.g., by the operating system or the platform forcibly stopping further execution of the agent code).", "If the agent has terminated, then the method continues at 1120.At 1120, the agent upgrade is performed and the agent is reinitiated.", "The agent upgrade can be performed by replacing one or more components (or the entirety) of the agent code and/or adding new agent code.", "Re-initiation can occur by the upgraded agent being executed in its appropriate agent execution environment.", "At 1122, a determination is made as to whether the upgraded agent has started executing again.", "If so, then, at 1124, the state of the agent is restored from the stored snapshot; otherwise, the agent will be restarted from a clean data store when it starts again.", "In particular implementations, the agent upgrade process is called by the agent packaging and instantiation module 522.The agent upgrade process can call into one or more of an agent snapshot process, a resource manager process (e.g., an “agent run check” process and/or “agent termination” process performed by the resource manager), agent execution process (e.g., a “start new agent” process or “restore agent from snapshot” process performed by the agent execution environment 540) 5.Agent Validation FIG.", "12 is a flow chart showing an exemplary technique 1200 for performing an authentication and authorization process.", "Typically, the technique 1200 is performed by a host on the network (e.g., an intelligent sensor or intelligent controller (or other node on the network) that includes computing hardware for implementing the agent-based software platform (e.g., the software platform 500)) when an agent is received.", "In particular embodiments, the technique 1200 is performed by the authentication and authorization module 510 in the software platform 500.In particular implementation, the authentication and authorization process 1200 is part of a common module for validation of authentication, authorization, and identity.", "At 1210, a determination is made as to whether the agent signature is valid.", "For example, a cryptographic signature sent with the agent transport payload can be checked and verified (e.g., using public key data stored in the trust store 512).", "The agent signature can be the signature from one or more of the creator, the initiator, and/or the previous host (e.g., the sender).", "If the agent signature is not valid, the agent is discarded at 1212; if the agent signature is valid, the technique 1200 continues at 1214.At 1214, a determination is made as to whether the identity of the initiator is valid.", "For instance, the trust store 512 can be checked to determine whether the identity of the agent's initiator matches an initiator in the trust store.", "If the initiator identity is not valid, the agent is discarded at 1216; if the initiator identity is valid, the technique 1200 continues at 1218.At 1218, a determination is made as to whether the initiator is authorized to dispatch an agent to the host and whether the SOI of the initiator matches the SOI of the device.", "For instance, the trust store 512 can be checked to determine whether the agent's initiator is an authorized initiator.", "If the initiator is not authorized, the agent is discarded at 1220; if the initiator is authorized, the technique 1200 continues at 1222.At 1222, a determination is made as to whether the configuration data included with the immutable data is authentic.", "For instance, a hash of the configuration data can be created and compared to a decrypted hash for the configuration data sent with the agent transport payload.", "The hash for the configuration data can be signed by one or more of the previous host (e.g., the sender), the initiator, or the creator, and can be decrypted using the public keys for these entities.", "The signed hash for any one or more (or all) of the sender, the initiator, or the creator can be used to authenticate the configuration data.", "If the configuration data is not authentic, the agent is discarded at 1224; if the immutable data is authentic, the technique 1200 continues at 1226.At 1226, a determination is made as to whether the mutable data is authentic.", "For example, a hash of the mutable data can be created and compared to a hash sent with the agent transport payload.", "For example, the hash for the mutable data can be signed by the previous host (e.g., the sender) and can be decrypted using the public key for the sender.", "If the mutable data is not authentic, the agent is discarded at 1228; if the mutable data is authentic, the technique 1200 continues at 1230.At 1230, a determination is made as to whether resources are available to perform the agent's task.", "For example, the resource requirements stored as part of the execution contract data 626 in the agent transport payload can be extracted and compared to available resources using information from the resource monitor 530.If sufficient resources do not exist, the agent is discarded at 1232; if sufficient resources exist, then the technique 1200 generates an indication that the agent is authorized and authenticated (e.g., by setting a flag, variable, or other parameter) In particular implementations, the process 1200 is called by an agent initiation process (e.g., agent initiation process 900 shown in FIG.", "9) and/or by an agent execution process (e.g., agent execution process 1000 shown in FIG.", "10).", "The authentication and authorization process 1200 can call into one or more of the following: a signature validation process, an authorization validation process, a data authorization validation process, a data authentication process, and/or a resource manager process (e.g., an “are resources available” process performed by the resource monitor module 530).", "V. Exemplary Applications for Embodiments of the Disclosed Intelligent Sensors and Controllers In this section, exemplary applications for the disclosed agent-based, intelligent sensors and intelligent controllers are described.", "The applications disclosed in this section are not to be construed as an exhaustive list, but are illustrative of the operation and capabilities of the disclosed technology.", "A.", "Distributed Generation as a Forecastable Resource Currently, there is uncertainty about the integration of distributed resources such as rooftop solar panels, end-customer wind turbines, end-customer battery storage, and plug-in hybrid electric vehicles (“PHEVs”).", "For example, an electricity generator plugged into the electric power system at the distribution layer is treated as “negative” load.", "This means that it is not actively accounted for and is not integrated into the electricity operations planning like a bulk power generator.", "Specifically, even when ample capacity is available from distributed resources in the distribution system, the current system is unable to accommodate this capacity by flowing power from the distribution system back to the transmission system and to a different location where the power may be needed.", "One exemplary application of the disclosed technology is to forecast and aggregate distributed resources that are connected (electrically) to the distribution system.", "In one implementation, this application can be performed using an embodiment of the disclosed software framework and can have the following components: (1) a forecaster/historian agent located at the distribution substation; (2) resource availability agents that gather a list of distributed resources and monitor their status in real time; and (3) resource integration agents that are responsible for collecting resource generation information.", "The collected information can then be made available to the forecaster located at the distribution substation.", "For instance, the distributed resource forecaster can collect information generated by the agents and use this information for generating forecasts for the resources at a variety of future times (e.g., 60 minutes ahead, 360 minutes ahead, 24 hours ahead, or any other forward-looking time interval).", "A variety of forecasting techniques can be used to generate the forecast as are known in the art.", "These forecasts can be made available to the utility system operations center and can be treated similar to a forecast coming from a bulk power generator.", "B. Sequencing Load in the Distribution System Consumer loads are largely resources that are not under the control of the utility.", "A demand/response architecture uses two-way communication between the utilities and consumers and allows the utility to shed certain loads during peak loads.", "One side effect of this type of technology, however, is that the loads get synchronized and the resulting power draw on the feeders has large peaks and valleys.", "This causes almost the opposite effect of the desired resource management goals.", "To control consumer loads more effectively, one application of the disclosed technology is to use the agent-based framework to sequence certain types of consumer base loads, providing a more stable equivalent load to the sub-transmission system.", "For instance, consider a neighborhood in which each of the water heaters has an intelligent controller allowing for intra-feeder communication.", "Through an automatic negotiation process between two or more controllers, the intelligent controllers can determine that they have peak usage in the morning and rather than all turning on at the same time, they can generate a time-slicing sequence that allows the water heaters to heat water one (or two, or more) at a time.", "Additionally, the intelligent controllers can be aware of typical usage times and pre-heat in a similar fashion.", "In particular implementations, if the temperature drops below some threshold, a device can drop out of the time-slicing mode and activate the water heater.", "Overall, however, the general use would be coordinated.", "Such time-slicing can not only be applied to water heater operation, but also to other controlled appliances (e.g., HVAC systems, dishwashers, washer and dryers, battery chargers, and the like).", "Further, a substation can receive knowledge of the time-slicing behavior on a feeder and use it for its own planning needs.", "In one example implementation, an agent-based framework can provide one or more of the following capabilities for performing load sequencing: (1) consumer-level distributed agent technology that can describe a load's characteristics (e.g., time of day, duration, frequency, seasonal adjustment, and the like); (2) sequencing and voting to develop a time-slicing scheme (e.g., based on load characteristics); and (3) automatic grouping of intelligent sensors and/or controllers into “smart” groups (e.g., based on the number of sensors and controllers in group, the sensors and controllers being on the same feeder, and the like).", "An exemplary embodiment of a load sequencing method is described below with respect to FIGS.", "13A and 13B.", "C. Goal-Based Demand Response There are two types of demand-response schemes currently employed in the electric power system.", "The traditional demand-response schemes are based on direct load control where a utility triggers a responsive asset to turn on and off by means of a communication channel.", "A second type of demand response uses a price signal to elicit customer behavior that results in a reduction of load through voluntary means.", "Note that while direct load control is deterministic, price-signal-based demand response is non-deterministic.", "In one exemplary implementation, the disclosed distributed agent technology is used for a collaborative demand response scheme with interacting agents that work together to achieve a demand management goal and confirm the amount of load reduction to the rest of the utility network, thereby alleviating the non-deterministic nature of price based demand response.", "For example, a zone controller can be identified as an entity that sets demand reduction goals for the zones that are under its control/influence.", "The zone controller can assign a load reduction goal to its subsidiaries, and this zone reduction goal can flow through the system from a first tier (which could be interpreted as a region controlled by a balancing authority) to one or more second-tier zones (e.g., utilities) and down to lower tiers (e.g., individual distribution substations).", "The agent framework can be extended to equipment located at customer premises as well.", "At each tier, the zone controllers can be implemented as “software agents”.", "The software agents can collaborate with each other, exchange information (securely), and iterate until desired goals are reached.", "In particular implementations, the amount of demand response achieved is collected and communicated up the zonal hierarchy to the first-tier zone controller.", "Therefore, the zone controller does not need to rely on metering observations to see whether the demand response scheme is working.", "Further, agents for each household can have different settings for different priorities (maintain power level vs. take advantage of price).", "Aggregate results of the interaction of those agents can be the response for the “neighborhood”.", "In some implementations, the agents at the residences collaborate with each other to prevent oscillatory load behaviors by coordinating when loads come online and go offline.", "The agents may also use a price signal for the communication of a demand response goal between tiers in the zonal hierarchy.", "In particular implementations, the collaborative demand response system is implementable at various layers of the electric power system, capable of communicating upward or downwards in the hierarchy, capable of moving and deploying agents based on other goals throughout the system (e.g., triggering of PHEVs to charge, or battery storage elements to charge), capable of crossing (or at least communicating across) organizational boundaries, and/or capable of accomplishing a goal/task in a short period of time (e.g., less than 300 seconds).", "In particular implementations, the zone controller agent is configured to communicate with agents in the levels above and below and/or to receive state information for agents below it in the hierarchy in order to form its state which it then reports to the hierarchy above.", "Further, the zone controller agent can be configured to receive a demand response goal from an agent higher in the hierarchy (which could be a human operator).", "The agent can then access its resources and task other agents to determine what its potential response can be.", "Further, the zone controller agent can be configured to receive a task from the above hierarchy and to distribute this to agents below.", "Further, the zone controller can be configured to request agents below for an estimate on demand reduction (which may ask agents below them), to aggregate the estimates, and to return the aggregated estimate.", "D. Automatic Topology Discovery Topology refers to the interconnection of resources in an electrical network.", "Traditionally, engineers explicitly define each of the interconnect possibilities.", "For instance, a SCADA engineer typically has to explicitly define each “tag” (voltage, current, and so on) within a substation, along with what electrical device it corresponds to (transmission line 47, or breaker 134, etc.).", "This process of explicitly defining the tags is both time consuming and susceptible to being quickly out-of-date.", "The difficulty in maintaining definitions for all tags in the system becomes more challenging when one considers a future electrical system filled with distributed generators constantly being added to the system and causing a need for updates to the network settings.", "In embodiments of the disclosed agent-based system, agents are used to facilitate the automatic discovery of data and topological interconnections.", "In particular implementations, an agent is programmed to have (or collect) knowledge of the electrical characteristics of the asset it is associated with, the location of the asset in the network, and/or the physical world identification of the asset.", "Further, the agent is programmed to advertise its available data upon request.", "Such embodiments can be used to reduce the barriers to wide area management as well as localized distribution level distributed generation.", "E. Localized State Estimation State estimation is a tool currently used by utilities in the control center to evaluate the stability of the electrical grid.", "In embodiments of the disclosed agent-based system, agents are used to collect state data.", "For example, the state eigenvalues (or other values) for a given substation can be measured directly in real-time by agents on the one or more feeders of the substation.", "These eigenvalues can then be transferred to the control center for a real-time state view of the power system.", "F. Automatic Fault Location Fault location typically refers to the ability to determine the physical location of the fault.", "Simple fault locators are attached to aerial power system lines and will trip a flag (or light up with blinking LEDs) during an unusually high current event, such as a short circuit.", "A lineman will use these indicators to manually locate a fault (typically on a distribution network).", "In exemplary embodiments of the disclosed agent-based system, agents are used to perform fault location on a distribution network.", "In certain implementations, the agent sensors have knowledge of their location on the electric power topology.", "Inter-agent communication during fault events could then be used to locate the effected sensors during an event.", "This information can assist utilities in the mitigation of a distribution-level outage, as well as provide a foundation technology for automatic outage management.", "In such implementations, the agents are configured to collect or have knowledge of their location on the power system, to have network connectivity, and to have a process for sending information about its state and location to a utility.", "G. Distribution-Level Wide-Area Protection Distribution refers to the low-level power system supply which feeds consumers, such as what is connected to the average house.", "Due to the numerous connections, the distribution network utilizes low cost electrical protection devices such as fuses and recloses.", "These devices have performed satisfactory in the past; however, they have shortcomings for needs of consumer-level distributed generation.", "In exemplary embodiments of the disclosed agent-based system, an agent is used to provide information that identifies the status of the distribution network at various nodes on the network.", "Such information could be collected by a common aggregator with the ability to detect abnormal conditions.", "If such a condition is detected, a backchannel communication can inform an agent on a distributed generator's controller to stop or to switch from delivering power into the power system to delivering power to one or more homes directly connected to the generator, thus mitigating a power system hazard.", "In particular implementations, load sensor are capable of publishing load parameters and allowing for remote control during safety events, generation sensors are capable of being coordinated, and a sequencer sensor is able to coordinate generation and load sensors as well as integrating with any existing SCADA infrastructure.", "VI.", "Example Implementation of an Agent for Performing Load Sharing This section describes exemplary methods for performing load sharing according to embodiments of the disclosed technology.", "The exemplary methods are described using the example of a substation that provides power to several homes.", "The substation receives energy goals from upstream (e.g., from a regional distributor) which the substation must meet to ensure smoother energy use throughout the grid.", "When the substation detects that energy use will be above the goal, it can send conserve signals to its houses asking them to reduce consumption.", "In this example, a house receives its energy from the substation.", "A house can have several appliances (e.g., an HVAC, refrigerator, and the like) as well as a base load which takes into account all other uses (e.g., lighting, television, and the like).", "In the discussion below, only water heaters are considered as controllable devices, but the agent-based scheme can be adapted to include other controllable devices as well (e.g., an HVAC system, electric vehicle chargers, and the like).", "In this example, the water heater draws power from its house.", "The water heater can be in one of two states: waiting or heating.", "While waiting, the water heater monitors the energy of the water (e.g., the temperature of the water, or a value based on the temperature and volume of the water in the heater) to determine if the energy is at its goal.", "If the water energy drops below a tank energy goal, then the heater enters the “heating” state, where it heats the water until it reaches the goal.", "Once the energy of the tank is at the goal, it goes back to the “waiting” state.", "The water heaters in this example also have a “low water mark” signal, which indicates that the tank energy is critically low.", "In this example, if a water heater is under its low water mark, its house will ignore a conserve request.", "Further, in this example, the inhabitants of the house are assumed to “consume” the resources of the house.", "For instance, each resident has a schedule for when they will take a shower which has the effect of reducing the energy in the water heaters tank.", "The example discussion in this section uses a “token”-based system.", "The token can be a software representation of a token and can be transmitted to agents associated with other homes.", "A house possessing a token (e.g., a house being assigned to the representation of the token) can draw its requested load from the substation.", "A house not possessing a token cannot draw its requested load from the substation.", "Furthermore, in the example below, a token allows a house to draw its required load for a set number of time cycles (e.g., 2-100 time cycles).", "The value of a token can begin at the total number of time cycles available with the token (e.g., 10).", "As a token is used for a given time cycle, the value of the token is decremented (e.g., decremented by one).", "When the token's value is 0, the token expires.", "Each token can have the same starting value, or can be individually tailored for a particular energy usage (e.g., the token can represent the number of time cycles necessary for raising the energy level of a water heater from its current state to its desired energy level).", "In one exemplary embodiment, an agent associated with the water heater is responsible for determining whether to operate the water heater or not.", "In one implementation, the decision-making process is performed at fixed time intervals (e.g., every 10 minutes, 5 minutes, 1 minute, 30 seconds, 10 seconds, 1 second, or any other period of time).", "For every time interval (also referred to as “ticks” or “time cycles”), there is a sequence of agent actions that happen.", "Water heaters in a waiting state enter a heating state if their tank energy is below goal.", "Water heaters in a heating state enter a waiting state if the tank is at its respective goal.", "Next, houses estimate their energy usage based on the state of their water heaters and their base energy usage.", "The substation receives these estimates and compares them against their load goal.", "If the total is over the load goal, the substation enters a conserve state.", "The substation in the conserve state sends a “conserve” signal to its houses and enters a monitor state if their estimate is under goal or a conserve timeout has elapsed.", "In certain embodiments, a house receiving a conserve signal polls its appliances as to their ability to conserve.", "Water heaters willing to conserve are maintained or switched back to their wait state.", "Several different exemplary techniques can be used by the agent at a house to control energy usage and attempt to keep the usage under the goal.", "Three exemplary techniques are described below: the global signal technique, the individual signal technique, and the cooperative technique.", "It should be understood that these techniques are introduced for illustrative purposes, and that additional or variations of these techniques are possible.", "According to the global signal technique, if the substation detects that energy use is over goal, then for some fixed period (e.g., 20 minutes, 10 minutes, 5 minutes, or any other period of time), the substation will send a conserve signal (such as a “high energy price” signal) to the houses that it controls (e.g., all houses).", "At each time cycle, a house can decide whether or not to honor the request.", "For instance, if “low water mark” signals are being honored, then the house will always ignore a conserve request if its water heaters energy is too low.", "According to the individual signal technique, at every time cycle that a substation detects energy use is over goal, it sends a conserve signal (such as a “high energy price” signal) individually to all houses that it serves.", "If a house chooses to respect the signal, then the house controls the water heater so it is shut off for some fixed period (e.g., 20 minutes, 10 minutes, or any other period of time).", "The conserve signal can be ignored if the “low water mark” is reached.", "According to the cooperative technique, household agents cooperate with one another in order to meet the substation's energy goal.", "For example, using a set of rules common to all the agents (and defined, for example, in the agent code 618 of the agent transport payload), an agent individually decides whether or not to claim an energy use token (e.g., for a current time cycle or a next upcoming time cycle).", "While the agent maintains the token, that house is allowed to meet its energy needs.", "According to one embodiment of the cooperative strategy, the houses follow the rules and respect assignment of the tokens.", "The global and individual techniques can also be run this way, but this leads to poor behavior.", "For instance, if all houses respect the conserve signal, then they will eventually synchronize, causing them all to turn on at once.", "If this causes the energy goal to be exceeded, then the substation will send out a conserve signal, causing all water heaters to turn off.", "The resulting pattern is one of spikes where all heaters turn on, then periods of inactivity while all heaters conserve.", "To overcome this problem, each house could have a random probability during each time cycle of respecting the conserve signal.", "In particular embodiments, household agents operating using the cooperative technique use a “belief-desire-intent” model of agent behavior.", "According to this model, the “belief” of the agent is based on states of the other agents (e.g., energy use, priority), the “desire” of the agent is based on the goals of the agent (e.g., to meet its substation's energy use goal while still maintaining quality of service to its resident), and the “intent” of the agent is based on their available actions (e.g., run their appliances or to conserve).", "In each time cycle, the household agents for the substation send their estimated energy use and their priority.", "In one implementation, the priority sent by an agent is (or corresponds to) the energy level of the water heater(s) in its associated home.", "This information forms each agent's beliefs about the current needs of their neighbors.", "Each agent then evaluates these beliefs against the desire to meet the energy goal of the substation while also keeping quality of service for their residents.", "To do this, each agent can operate using a common set of rules.", "FIGS.", "13A and 13B illustrate one exemplary process 1300 used by an agent to determine whether it should take an energy-use token.", "At 1310, an energy goal is received.", "For instance, the energy goal can be sent from the substation and stored locally at the agent's host until changed.", "At 1311, information from the other houses is received.", "The information received can include, for example, the identity of the house, the estimated energy use for the house, the priority of the house (e.g., the energy level of the water heater), the low water mark for the house, the tank energy goal for the house, and an indication of whether the house is using a token for the upcoming cycle (e.g., the next time cycle).", "At 1312, the base load required from each house is subtracted from the energy goal.", "At 1314, the energy for houses with a token for the upcoming time cycle is subtracted from the remainder of the energy determined at 1312.At 1316, a determination is made as to whether any energy remains.", "For example, in particular implementations, a determination can be made whether the remaining energy is sufficient to perform any of the estimated energy usages from the remaining houses without tokens.", "If there is insufficient energy, then the procedure is complete, and the houses with tokens run their appliances in the next time cycle but decrement their token value at 1317; if energy remains, the process proceeds at 1318.At 1318, a list of houses with no token is generated.", "At 1320, a determination is made as to whether any houses in the list are below the low water mark.", "If one or more houses are below the low water mark, then the process proceeds at 1322; otherwise, the process proceeds at 1332.At 1322, the house having a current energy level farthest from the low water mark is selected.", "At 1324, a determination is made as to whether the selected house is the house controlled by the agent.", "If so, the agent claims a token at 1326 and subtracts its energy usage from the remaining energy at 1328; otherwise, the agent just subtracts the selected house's energy usage from the remaining energy at 1328.At 1329, the selected house is removed from the list.", "At 1330, a determination is made as to whether any energy remains.", "For example, in particular implementations, a determination can be made whether the remaining energy is sufficient to perform any of the estimated energy usages from the remaining houses without tokens.", "If there is insufficient energy, then the procedure is complete, and the houses with tokens run their appliances in the next time cycle but decrement their token value at 1317; if energy remains, the process repeats at 1320.At 1332, a determination is made as to whether any houses in the list are below their tank energy goals.", "If one or more houses are below their respective tank energy goals, then the process proceeds at 1334; otherwise, the process proceeds at 1317, where houses with tokens run their appliances in the next time cycle but decrement their token value.", "At 1334, the house having a tank energy goal closest to (or farthest from) its respective tank energy goal is selected.", "At 1336, a determination is made as to whether the selected house is the house controlled by the agent.", "If so, the agent claims a token at 1338 and subtracts its energy usage from the remaining energy at 1340; otherwise, the agent just subtracts the selected house's energy usage from the remaining energy at 1340.At 1342, the selected house is removed from the list.", "At 1344, a determination is made as to whether any energy remains.", "For example, in particular implementations, a determination can be made whether the remaining energy is sufficient to perform any of the estimated energy usages from the remaining houses without tokens.", "If there is insufficient energy, then the procedure is complete, and the houses with tokens run their appliances in the next time cycle but decrement their token value at 1317; if energy remains, the process repeats at 1332.Acting by the rules set forth in process 1300 means that priority is given to those houses with the worst quality of service.", "This prevents “sacrificing” a house so that others may reach their goals faster.", "It also means that once a minimum is met, priority goes to the houses closest to reaching their goal in order to take them out of the equation.", "This simplifies the latter stages of planning.", "To test the exemplary method shown in FIG.", "13, a simulation was performed.", "In the simulation, the water heater was modeled as a 40 Gallon tank with two 4.5 KW heating elements.", "The first law of Thermodynamics, conservation of energy, provides the basis for calculating the water heater's load characteristics.", "The change in enthalpy is the energy required to heat the water to the desired 50° C. output based on the following equation: ΔH=mcpΔT (1) where ΔH is the change in enthalpy (J), m is the mass of the water (kg), cp is the specific heat of water at constant pressure (J/mol*K), ΔT is the change in temperature (° C.).", "For the 160 L tank (roughly equivalent to 40 Gallons) with an incoming water temperature of 10° C. and outgoing temperature of 50° C., the change in energy is approximately 30.8 MJ.", "Using the tank's 4.5 KW heating element will thus take approximately 114 minutes to heat the tank from an initial state.", "To model the usage requirements, the following parameters were used.", "The standard shower consumes 12 gallons of hot water, which in turn requires 9.6 MJ of energy to restore the tank to its heated condition, or 35.6 minutes to return a fully heated state.", "In other words, if the shower lasted 5 minutes, during that time the tank experienced a loss of energy at the rate of approximately 32 KW.", "The simulation was performed considering a single substation.", "Runs were done with the substation having 5 houses for each of the three techniques introduced above.", "Energy goals of 30, 35, and 45 were used.", "Each house had a baseload of 5 kW/s and each water heater consumed 4.5 kW/s when heating water in the tank.", "Residents took showers randomly between 6 a.m. and 7 a.m. with a random duration from 5 to 15 minutes.", "However, the behavior of the residents was consistent for each strategy during a run.", "The worst case for every system is when there is only enough room in the energy goal to run one house's water heater.", "As shown in Table 1 below and in FIG.", "14, the cooperative strategy performed in a more stable way than the other two strategies by avoiding peaks in demand.", "In particular, FIG.", "14 shows a representational snapshot of behavior for the global signal technique, the individual signal technique, and the cooperative technique.", "As shown in graph 1410, the global signal technique exhibited behavior that is desirably avoided: large initial spikes which trigger a conserve signal.", "After the 10-minute wait time, there was again a spike as all the water heaters turn on again then settle into chaotic behavior as water heaters decide to honor the signal or not.", "As shown in graph 1420, the individual signal technique still exhibited an initial peak, but the behavior is still much smoother than the global signal techniques.", "The number of time cycles the energy usage was over the goal is still very high especially when water heaters fall below their low water mark.", "As shown in graph 1430, the cooperative technique exhibited stable behavior and stayed at the load goal or below until all water heaters had recharged themselves.", "The model created for this simulation was not intended to be an exhaustive recreation of the power grid.", "TABLE 1 Average peak energy use, time cycles over load goal, and recovery time for different agent operational techniques given a load goal Energy Peak Time Cycles Recovery Goal Technique Energy Above Goal Time 40 Global-signal 64.7 6633.8 11:39 40 Individual-signal 58.4 4875.8 14:58 40 Cooperative 39.5 0 14:34 45 Global-signal 65.6 5058.4 10:18 45 Individual-signal 59.3 3974.4 12:58 45 Cooperative 44 0 10:33 60 Global-signal 64.7 642.4 8:38 60 Individual-signal 62 84.6 8:55 60 Cooperative 57.5 0 8:29 VII.", "Concluding Remarks Having described and illustrated the principles of the disclosed technology in the detailed description and accompanying drawings, it will be recognized that the various embodiments can be modified in arrangement and detail without departing from such principles.", "In view of the many possible embodiments to which the principles of the disclosed invention may be applied, it should be recognized that the illustrated embodiments are only preferred examples of the invention and should not be taken as limiting the scope of the invention.", "Rather, the scope of the invention is defined by the following claims and their equivalents.", "We therefore claim as our invention all that comes within the scope and spirit of these claims and their equivalents." ] ]
Patent_15875959
[ [ "BONE CONDUCTION DEVICE SUPPORT", "A prosthetic support, including a structure configured to apply a clamping force to a head of a recipient while extending about a back of at least one of a head or neck of the recipient such that output generated by a device supported by the structure is directed into skin of the recipient at a location behind an ear canal of the recipient that covers the mastoid bone of the recipient." ], [ "1.A prosthetic support, comprising: a structure configured to apply a clamping force to a head of a recipient while extending about a back of at least one of a head or neck of the recipient such that output generated by a device supported by the structure is directed into skin of the recipient at a location behind an ear canal of the recipient that covers the temporal bone of the recipient.", "2.The prosthetic support of claim 1, wherein: the structure is elastically flexibly biased such that the clamping force results from deformation of the structure due to interference of the structure with the head of the recipient relative to a geometry of the structure in a relaxed state.", "3.The prosthetic support of claim 2, wherein: the structure is generally “U” shaped, “C” shaped or segmented circle shaped in the relaxed state.", "4.The prosthetic support of claim 1, further comprising: a skin interface portion that is at least one of part of or directly attached to the structure, the skin interface portion being located on the support such that it abuts skin of the recipient at a location behind an ear canal of the recipient covering the temporal bone of the recipient when the clamping force is applied to the head of the recipient.", "5.The prosthetic support of claim 4, wherein: at least a substantial amount of the clamping force applied to the head of the recipient is applied through the skin interface portion.", "6.The prosthetic support of claim 4, wherein: the output includes vibrations generated by a bone conduction device; the skin interface portion is configured to transcutaneously transmit the vibrations into the skin of the recipient, from which the vibrations enter the temporal bone of the recipient, in amounts to provoke a hearing percept in the recipient, the vibrations traveling through the skin interface portion.", "7.The prosthetic support of claim 1, further comprising: a device attachment portion attached to or part of the structure, wherein the attachment portion is configured to removably attach the device to the prosthetic support, wherein the device is a medical device.", "8.The prosthetic support of claim 7, wherein: the medical device is a bone conduction device including a coupling apparatus; and the device attachment portion is configured to removably attach the coupling apparatus of the bone conduction device to the prosthetic support.", "9.The prosthetic support of claim 8, wherein: the attachment portion is configured to removably snap couple the coupling apparatus to the support.", "10.The prosthetic support of claim 1, wherein the device is a bone conduction device that generates vibrations and the output includes the generated vibrations, the prosthetic support further comprising: a skin interface portion that is part of or directly attached to the structure such that it abuts skin covering the temporal bone at a location behind an ear canal of the recipient, wherein a substantial amount of the clamping is applied via the skin interface portion, wherein the prosthetic support is configured to conduct the generated vibrations from the bone conduction device, through the skin interface portion and into the skin of the recipient, from which the vibrations enter the temporal bone of the recipient, in amounts to provoke a hearing percept in the recipient.", "11.The prosthetic support of claim 10, further comprising: a device attachment portion attached to or part of the structure, wherein the attachment portion is configured to removably attach the bone conduction device to the prosthetic support, wherein the skin interface portion and the device attachment portion are part of a modular assembly movably attached to the structure.", "12.The prosthetic support of claim 7, further comprising: a second device attachment portion at least one of attached to or part of the structure, wherein the second device attachment portion is configured to removably attach a second device to the prosthetic support, wherein the second device attachment portion is located on the structure substantially symmetrical with respect to the device attachment portion, and wherein the second device is a second medical device.", "13.The prosthetic support of claim 12, wherein: the medical device is a first bone conduction device including a first coupling apparatus; the device attachment portion is configured to removably attach the first coupling apparatus of the first bone conduction device to the support; the second medical device is a second bone conduction device including a second coupling apparatus; and the second device attachment portion is configured to removably attach the second coupling apparatus of the second bone conduction device to the support.", "14.The prosthetic support of claim 4, wherein: the support is configured to enable a recipient to adjust a location of the skin interface portion relative to the structure.", "15.The prosthetic support of claim 14, wherein: the skin interface portion is part of a module that is releasably secured to a given location of the structure, the module including a device attachment portion configured to removably attach the device to the prosthetic support; the support is configured to enable the module to be released from securement to the given location of the structure and moved to and releasably secured to another location of the structure, thereby enabling the recipient to adjust a location of the skin interface portion relative to the structure; and the device is a medical device.", "16.The prosthetic support of claim 14, wherein: the skin interface portion is slidably attached to the structure; and the support is configured with at least one of a friction fit or an interference fit between the skin interface portion and the structure that enables the skin interface portion to slide along the structure upon application of sufficient force to the skin interface portion to overcome the fit, thereby enabling the recipient to adjust a location of the skin interface portion relative to the structure.", "17.The prosthetic support of claim 1, wherein: the structure includes a plurality of sub-structures, at least one of which is spatially adjustable relative to the other.", "18.The prosthetic support of claim 17, wherein: the plurality of sub-structures include at least a first sub-structure and a second sub-structure; and the first sub-structure is configured to telescope towards and away from the second sub-structure to enable a location of a component of the prosthetic support linked to the first sub-structure to be moved relative to the second sub-structure.", "19.The prosthetic support of claim 4, wherein the structure comprises: a first sub-structure on which the skin interface portion is mounted; and a second-sub structure, wherein the first sub-structure is configured to telescope towards and away from the second sub-structure to enable a location of the skin interface portion to be moved relative to the second sub-structure.", "20.The prosthetic support of claim 4, wherein: the device is a bone conduction device including a coupling apparatus; and the skin interface portion comprises: an attachment portion configured to attach the coupling apparatus of the bone conduction device to the skin interface portion; a body portion configured to connect the skin interface portion to the structure; and an adhesive portion configured to adhesively removably retain the skin interface portion to skin of the recipient.", "21.The prosthetic support of claim 1, wherein the output is configured to at least one of stimulate an organ or stimulate a device implanted in the recipient.", "22.A medical device, comprising: the prosthetic support of claim 1; and the device, wherein the device includes a telecoil, wherein the clamping force is sufficient to hold the telecoil in proximity to the skin to place the telecoil into transcutaneous electromagnetic communication with an implanted medical device implanted beneath the skin of the recipient.", "23.A headset for a bone conduction device, comprising: a headset configured to support at least one bone conduction device and configured to provide a clamping force reactive against a head of the recipient sufficient to transmit vibrations from the bone conduction device into skin of the recipient at a location where the skin covers the temporal bone behind an ear canal of the recipient, wherein the headset is configured such that a center of gravity of the headset, during normal use, is located behind and, with respect to a vertical direction, at least one of about level with or below the location.", "24.The headset of claim 23, wherein: the headset is configured to maintain a position of the headset, relative to the recipient, such that the vibrations are transmitted into the skin of the recipient without a component extending about a top of the head.", "25.The headset of claim 24, wherein: the headset is configured to maintain the position while the recipient is subjected to 5 G-forces in the vertical direction.", "26.The headset of claim 23, wherein: the headset is configured to snap couple to the bone conduction device supported by the headset.", "27.The headset of claim 23, wherein: the headset includes a structure configured to extend about a back of at least one of a head or neck of the recipient; an attachment portion configured to removably attach the at least one bone conduction device to the support; and the headset is configured such that the attachment portion articulates relative to the structure.", "28.The headset of claim 23, wherein: the headset is configured to substantially vibrationally isolate the headset from the vibrations.", "29.A hearing prosthesis, comprising: a bone conduction device; and means for supporting the bone conduction device such that vibrations from the bone conduction device are transferred into skin of a recipient of the bone conduction device covering the temporal bone at a location behind an ear canal of the recipient, wherein the means is completely external to the recipient.", "30.The hearing prosthesis of claim 29, wherein: the bone conduction device is removably snap-coupled to the means for supporting the bone conduction device." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>In one aspect of the present invention, there is a prosthetic support, comprising a structure configured to apply a clamping force to a head of a recipient while extending about a back of at least one of a head or neck of the recipient such that output generated by a device supported by the structure is directed into skin of the recipient at a location behind an ear canal of the recipient that covers the mastoid bone of the recipient.", "In another aspect of the present invention, there is a headset for a bone conduction device, comprising a headset configured to support at least one bone conduction device and configured provide a clamping force reactive against a head of the recipient sufficient to transmit vibrations from the bone conduction device into skin of the recipient at a location where the skin covers the mastoid bone behind an ear canal of the recipient, wherein the headset is configured such that a center of gravity of the headset, during normal use, is located behind and, with respect to a vertical direction, at least one of about level with or below the location.", "In another aspect of the present invention, there is a hearing prosthesis, comprising a bone conduction device; and means for supporting the bone conduction device such that vibrations from the bone conduction device are transferred into skin of a recipient of the bone conduction device covering the mastoid bone at a location behind an ear canal of the recipient, wherein the means is completely external to the recipient." ], [ "BACKGROUND Field of the invention The present invention relates generally to hearing prostheses and, more particularly, to a support for bone conduction hearing prostheses.", "Related Art For persons who cannot benefit from traditional acoustic hearing aids, there are other types of commercially available hearing prostheses such as, for example, bone conduction hearing prostheses(commonly referred to as “bone conduction devices”).", "Bone conduction devices mechanically transmit sound information to a recipient's cochlea by transferring vibrations to a person's skull.", "This enables the hearing prosthesis to be effective regardless of whether there is disease or damage in the middle ear.", "Traditionally, bone conduction devices transfer vibrations from an external vibrator to the skull through a bone conduction implant that penetrates the skin and is physically attached to both the vibrator and the skull.", "Typically, the external vibrator is connected to the percutaneous bone conduction implant located behind the outer ear facilitating the efficient transfer of sound via the skull to the cochlea.", "The bone conduction implant connecting the vibrator to the skull generally comprises two components: a bone attachment piece (e.g., bone fixture/fixture) that is attached or implanted directly to the skull, and a skin penetrating piece attached to the bone attachment piece, commonly referred to as an abutment.", "SUMMARY In one aspect of the present invention, there is a prosthetic support, comprising a structure configured to apply a clamping force to a head of a recipient while extending about a back of at least one of a head or neck of the recipient such that output generated by a device supported by the structure is directed into skin of the recipient at a location behind an ear canal of the recipient that covers the mastoid bone of the recipient.", "In another aspect of the present invention, there is a headset for a bone conduction device, comprising a headset configured to support at least one bone conduction device and configured provide a clamping force reactive against a head of the recipient sufficient to transmit vibrations from the bone conduction device into skin of the recipient at a location where the skin covers the mastoid bone behind an ear canal of the recipient, wherein the headset is configured such that a center of gravity of the headset, during normal use, is located behind and, with respect to a vertical direction, at least one of about level with or below the location.", "In another aspect of the present invention, there is a hearing prosthesis, comprising a bone conduction device; and means for supporting the bone conduction device such that vibrations from the bone conduction device are transferred into skin of a recipient of the bone conduction device covering the mastoid bone at a location behind an ear canal of the recipient, wherein the means is completely external to the recipient.", "BRIEF DESCRIPTION OF THE DRAWINGS Embodiments of the present invention are described herein with reference to the attached drawing sheets in which: FIG.", "1 is a perspective view of a percutaneous bone conduction device with which embodiments may be used; FIG.", "2 depicts a side view and a cross-sectional view of a bone conduction device used with an exemplary embodiment; FIG.", "3A depicts an isometric view of a support according to an exemplary embodiment; FIG.", "3B depicts a top view of the support depicted in FIG.", "3A; FIG.", "3C depicts the support of FIGS.", "3A and 3B worn as intended on a recipient; FIG.", "4 depicts a cross-sectional view of a skin interface portion of the embodiment of FIG.", "3A; FIG.", "5 depicts an isometric view of a hearing prosthesis using the support of FIG.", "3A; FIG.", "6 depicts an isometric view of a modular skin interface portion usable with some embodiments of the support detailed herein; FIG.", "7A depicts an alternate embodiment of a support in which structure providing a clamping force on the recipient includes a plurality of substructures; FIG.", "7B depicts an alternate embodiment of a support in which structure providing a clamping force on the recipient includes a substructure that articulates relative to another substructure; and FIG.", "8 presents an exemplary flowchart for an exemplary method according to an embodiment.", "DETAILED DESCRIPTION In an exemplary embodiment, there is a prosthetic support, such as a support for a bone conduction device.", "The support is configured to apply a clamping force to a head of a recipient while extending about a back of at least one of a head or neck of the recipient.", "The clamping force is sufficient to permit, in the case of a support for a bone conduction device, vibrations generated by the bone conduction device to be directed into skin of the recipient at a location behind an ear canal of the recipient covering the mastoid bone of the recipient to stimulate the cochlea of the recipient, thereby providing a hearing percept.", "In an exemplary embodiment, the structure of the support is in the form of a resiliently flexible arch that extends from one side of the recipient's head to the other side of the recipient's head.", "The resilient nature of the arch provides the clamping force when the head of the recipient is interposed inside the arch.", "The clamping force is sufficient to hold the arch in place without a component that extends in front of the head of the recipient and/or a component that extends above the top of the recipient.", "In an exemplary embodiment, the support is configured to enable one or more bone conduction devices to removably snap couple to the support, thus permitting the support to be utilized with existing bone conduction devices (such as, for example, percutaneous bone conduction devices that utilize a snap-couple feature).", "Further, the support may be adjusted without the use of tools so as to adjust a location of a skin interface portion of the support.", "Additional details of the support are provided below, but first, a brief discussion of an exemplary bone conduction device with which some exemplary supports may be utilized will now be provided.", "FIG.", "1 is a perspective view of a bone conduction device 100 in which embodiments of the present invention may be implemented.", "As shown, the recipient has an outer ear 101, a middle ear 102 and an inner ear 103.Elements of outer ear 101, middle ear 102 and inner ear 103 are described below, followed by a description of bone conduction device 100.In a fully functional human hearing anatomy, outer ear 101 comprises an auricle 105 and an ear canal 106.A sound wave or acoustic pressure 107 is collected by auricle 105 and channeled into and through ear canal 106.Disposed across the distal end of ear canal 106 is a tympanic membrane 104 which vibrates in response to acoustic wave 107.This vibration is coupled to oval window or fenestra ovalis 210 through three bones of middle ear 102, collectively referred to as the ossicles 111 and comprising the malleus 112, the incus 113 and the stapes 114.The ossicles 111 of middle ear 102 serve to filter and amplify acoustic wave 107, causing oval window 210 to vibrate.", "Such vibration sets up waves of fluid motion within cochlea 139.Such fluid motion, in turn, activates hair cells (not shown) that line the inside of cochlea 139.Activation of the hair cells causes appropriate nerve impulses to be transferred through the spiral ganglion cells and auditory nerve 116 to the brain (not shown), where they are perceived as sound.", "FIG.", "1 also illustrates the positioning of bone conduction device 100 relative to outer ear 101, middle ear 102 and inner ear 103 of a recipient of device 100.As shown, bone conduction device 100 is positioned behind outer ear 101 of the recipient and comprises a sound input element 126 to receive sound signals.", "Sound input element may comprise, for example, a microphone, telecoil, etc.", "In an exemplary embodiment, sound input element 126 may be located, for example, on or in bone conduction device 100, or on a cable extending from bone conduction device 100.In an exemplary embodiment, bone conduction device 100 comprises an operationally removable component removably attached to a bone conduction implant.", "By operationally removably attaches, it is meant that it is removable in such a manner that the recipient can relatively easily attach and remove the operationally removable component during normal use of the bone conduction device 100.This as contrasted with how the bone conduction implant is attached to the skull, which is attached via a bone screw.", "The bone conduction device includes a sound processor (not shown), a vibrating electromagnetic actuator (not shown) and/or various other operational components, such as sound input device 126.More particularly, sound input device 126 (e.g., a microphone) converts received sound signals into electrical signals.", "These electrical signals are processed by the sound processor.", "The sound processor generates control signals which cause the actuator to vibrate.", "In other words, the actuator converts the electrical signals into mechanical motion to impart vibrations to the recipient's skull.", "As illustrated, bone conduction device 100 further includes a coupling apparatus 140 configured to operationally removably attach the bone conduction device to a bone conduction implant (also referred to as an anchor system and/or a fixation system) which is implanted in the recipient.", "In the embodiment of HG.", "1, coupling apparatus 140 is coupled to the bone conduction implant (not shown) implanted in the recipient.", "Briefly, an exemplary bone conduction implant may include a percutaneous abutment attached to a bone fixture via a screw, the bone fixture being fixed to the recipient's skull bone 136.The abutment extends from the bone fixture which is screwed into bone 136, through muscle 134, fat 128 and skin 232 so that coupling apparatus 140 may be attached thereto.", "Such a percutaneous abutment provides an attachment location for coupling apparatus 140 that facilitates efficient transmission of mechanical force.", "FIG.", "2 depicts additional details of an exemplary embodiment of a bone conduction device 100 usable with at least some embodiments as detailed herein and variations thereof Particularly, bone conduction device 100 is a percutaneous bone conduction device that includes a coupling apparatus 140 configured to attach the bone conduction device 100 to an abutment connected to a bone fixture implanted in the recipient.", "As illustrated, the coupling apparatus 140 includes a coupling 142 in the form of a snap coupling configured to “snap couple” to a bone fixture system on the recipient.", "In an embodiment, the coupling 142 corresponds to the coupling described in U.S. patent application Ser.", "No.", "12/177,091 assigned to Cochlear Limited.", "In an alternate embodiment, a snap coupling such as that described in U.S. patent application Ser.", "No.", "12/167,796 assigned to Cochlear Limited is used.", "In yet a further alternate embodiment, a magnetic coupling such as that described in U.S. patent application Ser.", "No.", "12/167,851 assigned to Cochlear Limited is used instead of or in addition to coupling 241 or the snap coupling of U.S. patent application Ser.", "No.", "12/167,796.The coupling apparatus 140 is mechanically coupled, via mechanical coupling shaft 143, to a vibrating actuator (not shown) within the bone conduction device 100.In an exemplary embodiment, the vibrating actuator is a device that converts electrical signals into vibration.", "In operation, sound input element 126 converts sound into electrical signals.", "Specifically, the bone conduction device provides these electrical signals to the vibrating actuator, or to a sound processor that processes the electrical signals, and then provides those processed signals to a vibrating actuator.", "The vibrating actuator converts the electrical signals (processed or unprocessed) into vibrations.", "Because vibrating actuator is mechanically coupled to coupling apparatus 140, the vibrations are transferred from the vibrating actuator to the coupling apparatus 140 and then to the recipient via the bone fixture system (not shown).", "FIG.", "3A depicts an exemplary embodiment of a bone conduction device support 300.It is noted that while most embodiments detailed herein will be described in terms of a bone conduction device support, other embodiments include a support fur other types of medical devices.", "Such exemplary medical device supports may include, for example, a support for an external component of a cochlear implant, a support for an external component for a middle ear implant, etc., examples of some of these being described in further detail below.", "Still further, some embodiments are directed towards prosthetic supports used to support luxury and/or functional devices where there is no medical necessity for such devices (e.g., bone conduction devices used as an alternate method of stimulating the cochlea in a person with normal hearing capability).", "While the just-mentioned examples are described in terms of hearing prostheses, it is noted that other medical device supports consistent with the teachings herein and variations thereof may be practiced to support other types of medical devices or other devices other than hearing prosthesis components.", "Referring to FIGS.", "3A and 3B, bone conduction device support 300 includes a structure 310 that is generally circular shaped and is segmented at one location.", "Bone conduction device support 300 includes an elongated structure 310 in a form that is resiliently flexible such that the outer diameter of the generally circular shaped structure 310 may be resiliently expanded from that depicted in FIG.", "3A and 3B/ends 301 and 302 may be moved away from each other from the location depicted in FIG.", "3A and 3B.", "That is, the configuration of the elongated structure 310 depicted in FIGS.", "3A and 3B depicts the elongated structure 310 in a relaxed state where no exterior forces are applied to the elongated structure 310, such as the force applied thereto by the head of a recipient.", "In this regard, bone conduction device support 300 is configured to be placed around a portion of a head of a recipient 3000 as may be seen in FIG.", "3C.", "Elongated structure 310 corresponds to structure that is flexibly biased such that a clamping force results on the recipient's head in reaction to the deformation of the elongated structure outward (i.e., expanded outer diameter) due to interference of the elongated structure 310 with the head of the recipient relative to the geometry of the elongated structure 310 in a relaxed state.", "In an exemplary embodiment, elongated structure 310 is constructed, arranged and dimensioned such that it will apply a sufficient clamping force to the head of a recipient such that the support 300 will be retained to the head of the recipient to permit efficacious functionality of the device supported by the support, as will be further detailed below.", "In an exemplary embodiment, the structure is configured to apply a clamping force, where such force may vary with head size, with the force being greater when used with heads of larger size owing to the greater deformation of the structure (for supports of the same design used on different heads).", "Additional specifics of ergonomic/human factors features pertaining to variations in head size of recipients are discussed in greater detail below.", "Elongated structure 310 corresponds to structure that may be made entirely out of a material that is elastically deformable in a manner sufficient to practice embodiments detailed herein and variations thereof.", "In yet other embodiments, elongated structure 310 may be made out of metal such as aluminum, flexible steel (e.g., spring steel), or other types of metals and/or metal alloys and/or non-metals that will permit the elongated structure 310 to elastically deform in accordance with embodiments detailed herein and variations thereof.", "In yet other embodiments, the elongated structure 310 may be a composite structure made of metal strands encased in plastic or rubber or some other material that will provide the requisite elastic deformations and/or ergonomic features.", "Any type of material may be used to form the elongated structure 310 providing the embodiments detailed herein and variations thereof may be practiced.", "As noted above and may be seen in FIGS.", "3A and 3B, elongated structure 310 is in the general shape of a segmented circle when the elongated structure 310 is in a relaxed state (e.g., when no head of a recipient is interposed inside the elongated structure 310).", "When a head of a recipient is interposed inside elongated structure 310/interposed between the ends 301 and 302 of the elongated structure 310, the elongated structure 310 deforms from the generally segmented circle shape of its relaxed state to a “C” shape or a “U” shape.", "It is noted that when the elongated structure 310 is referred to in the relaxed state, the relaxed state includes a state where ends 301 and 302 are contacting each other, thus preventing the elongated structure 310 from elastically deforming further inward (i.e., the overall outside diameter of the elongated structure 310 would decrease more but for contact between the ends of the elongated structure 310).", "Accordingly as used herein, the phrase relaxed state refers to the state of the elongated structure 310 when there is no other object that is not part of the bone conduction device support 300 interposed inside elongated structure 310/in between ends 301 and 302 of elongated structure 310.While the Elongated structure 310 of FIGS.", "3A and 3B have been depicted and described in terms of a structure that forms a segmented circle when in the relaxed state, other embodiments may utilize a structure that is generally “C” shaped or generally “U” shaped when the elongated structure 310 is the in the relaxed state, Any size or shape of an elongated structure 310 may be used in some embodiments providing that such an elongated structure will enable the embodiments detailed herein and variations thereof to be practiced.", "Indeed, in other embodiments, other types of structure other than an elongated structure may be utilized.", "In this regard, structure corresponding to, for example, a partial helmet (such as a helmet that only covers a back of a head), a full helmet (e.g., U.S. football helmet, bicycle helmet, war fighter helmet, etc.)", "may be utilized as structure for a medical device support.", "Any type of structure that provides the clamping capabilities and/or adjustment capabilities detailed herein and variations thereof and permits the medical device supported thereby to have efficacy may be used in some embodiments.", "From FIGS.", "3A-3C, it can be seen that the embodiments of the support 300 depicted therein correspond to an embodiment that utilizes an elongated structure 310 that substantially extends parallel to a plane.", "However, in other embodiments, structure 310 may extend in a varying matter.", "By way of example and not by way of limitation, support 300 may extend downwards in front of the ear of the recipient.", "That is, instead of extending parallel to a plane to which the rest of the structure 310 extends in a parallel manner, the portions of structure 310 making up sections 314 may extend downward, or alternatively, upward, or may extend in both directions.", "In an alternate embodiment, the mid-portions of structure 310 (e.g., those portions which would be located in the back when placed on recipient 3000) may extend downward such that a portion of the structure 310 rests on the location of the recipient at or between the shoulders and the beginning of the neck of the recipient 3000, thereby providing some additional support in the vertical direction against gravity and/or downward vertical acceleration for the support 300.Any configuration of structure 310 may be used in some embodiments providing that the embodiments detailed herein and variations thereof may be practiced.", "With reference to FIGS.", "3B and 3C, it will be seen that support 300 includes section 312 that corresponds to portions of the support 300 that are located, for at least the most part, behind the ear canal of the recipient 3000 when the support 300 is worn by the recipient (where ‘behind’ is with reference to the vertical direction when the recipient is looking directly forward).", "Further, support 300 includes section 314 that corresponds to portions of the support 300 that are located, for at least the most part, in front of the ear canal of the recipient 3000 when the support 300 is worn by the recipient (where ‘in front’ is with reference to the vertical direction when the recipient is looking directly forward).", "Sections 314 include the foam pad 350, as may be seen.", "It is noted that in other embodiments, the structure 310 may stop at or about at the ends of section 312.That is, some embodiments of the support 300 may not have sections 314 that extend in front of the ear canal of the recipient 3000.Further, in embodiments that have sections 314, these sections may not extend as far in front of the ear canal of the recipient 3000 as depicted in the FIGs., while in other embodiments, section 314 may extend even further in front of the ear canal than that depicted in the FIGS.", "It is noted that in the embodiments depicted herein, the elongated structure is depicted as a structure that extends from one side of the support to the other side of the support, in other embodiments, the elongated structure 310 may extend only a portion of the way about the support, where another structure having a different configuration or even the same configuration may be connected to structure 310, this alternate structure extending away from structure 310.Support 300 includes skin interface portions 320.A portion or all of skin interface portions 320 may be part of the structure of elongated structure 310 (e.g., monolithic therewith) or may be a component that is attached to the structure of the elongated structure 310 (that is, skin interface portions 320 may be separate components mechanically attached to the elongated structure), or may be a combination thereof.", "Skin interface portions 320 are located at positions on support 300 and configured such that the inner surfaces of the skin interface portions 320 abut skin of the recipient at a location behind the ear canal of the recipient where the skin covers the mastoid bone of the recipient.", "This may be seen in FIG.", "3C, which depicts placement of the support 300 about the head of a recipient 3000 so as to enable one or more bone conduction devices (not shown) supported by the support to provide a hearing percept to the recipient 3000 as will be detailed further below.", "Still with reference to the skin interface portions 320, in the embodiment depicted in FIGS.", "3A and 3B, a substantial amount (including all) of the aforementioned clamping force that results from the structure of the elongated structure 310 due to interference of the structure 310 with the head of a recipient is applied through the skin interface portions 320.It is noted that in some embodiments, there may be ancillary contact between other parts of support 300/other parts of elongated structure 310 and the head and/or body of the recipient, as will be described below.", "That is, the fact that the clamping force applied to the head of the recipient is applied substantially through the skin interface portion does not exclude ancillary contact and even ancillary clamping force applied by other portions of the support 300.In this regard, the exemplary embodiment of the support 300 depicted in FIGS.", "3A and 3B includes pads 350 located at ends 301 and 302 of the elongated structure 310.Pads 350 may be made of foam, silicone, or other type of material that cushions or otherwise provides an ergonomic interface between the support 300 and the skin of the head of the recipient.", "In some embodiments, some clamping force applied by the support 300 to the head is transferred through the foam pads 350, while in other embodiments, the pads 350 primarily are utilized to provide an additional area of friction between the skin of the recipient and the support so as to provide a reaction against, for example, downward movements of the support.", "Indeed, in some embodiments, pads 350 provide additional stability to the support 300 relative to the head of the recipient.", "Referring to FIG.", "4, which depicts a cross section taken through skin interface portion 320 of support 300, with reference to the cross-sectional indication depicted in FIG.", "3A, it can be seen that skin interface portion 320 includes a portion 421 that extends from the general profile of elongated structure 310.Skin interface portion includes an adhesive 440 that enhances adherence of the skin interface portion 320 to the skin of the recipient at a location behind the ear canal of the recipient 3000.In this regard, FIG.", "4 depicts an exemplary embodiment where a portion of skin interface portion is monolithic with structure 310 and a portion (adhesive 440) that is attached to structure 310.It is noted that in some embodiments, adhesive 440 is not present in the skin interface portion and/or is located at other locations (e.g.", "at ends 301 and 302 of the elongated structure 310).", "Also, in some embodiments, adhesive 440 may be covered with a seal or the like that is removable to expose the adhesive just prior to use.", "It is noted that a pad may be positioned over adhesive 440 where the adhesive is used to adhere the pad to the elongated structure 310 and/or element 440 may be a pad that is mechanically connected to elongated structure 310.Such a pad may not include adhesive on the skin side.", "Note further that element 440 may be a pad molded to elongated structure 310 and/or part of elongated structure 310.As may be seen in FIG.", "4, skin interface portion 320 includes a bone conduction device attachment portion 330 configured to removably attach the coupling apparatus 140 of bone conduction device 100 to the support 300.FIG.", "5 depicts bone conduction devices 100 attached to support 300 at the bone conduction device attachment portions 330.While the embodiment depicted in FIG.", "4 will be described in terms of the bone conduction device attachment portion 330 being part of the skin interface portion 320, alternate embodiments may be practiced where the bone conduction device attachment portion 330 is a separate component (i.e., it is not part of the skin interface portion 320).", "It is noted that while the bone conduction device attachment portion 330 is depicted as a separate structure relative to the elongated structure 3110 (e.g., the structure of attachment portion 330 may be interference fitted or screw fitted, etc., into a bore into elongated structure 310) in other embodiments, bone conduction device attachment portion 330 may be part of the elongated structure 310 (e.g., it may be machined directly into metal or plastic or otherwise formed into the metal or plastic of the elongated structure 310).", "An exemplary bone conduction device attachment portion 330 corresponds to, at least in part, the receptacle portion of a percutaneous abutment utilized in a percutaneous bone conduction implant.", "In an exemplary embodiment, bone conduction device attachment portion 330 is configured to enable removable attachment to the coupling in a manner substantially the same as that taught by and/or as would be understood to be a variation consistent with, the teachings of U.S. patent application Ser.", "No.", "12/177,091 and/or Ser.", "No.", "12/167,796 and/or Ser.", "No.", "12/167,851 assigned to Cochlear Limited.", "By way of example, bone conduction device attachment portion 330 may enable snap-coupling/decoupling to/from a bone conduction device, magnetic coupling/decoupling to/from a bone conduction device, etc.", "In some embodiments, bone conduction device attachment portion 330 may correspond to any type of attachment portion that will permit a bone conduction device to be attached and/or detached to/from the support 300.With respect to the embodiment depicted in FIG.", "4, bone conduction device attachment portion 330 may function in a manner substantially the same as a percutaneous abutment utilized in a percutaneous bone conduction implant.", "The bone conduction device attachment portion 330 may have a geometry, at least with respect to the receptacle portion of the bone conduction device attachment portion 330, substantially similar to (including the same as) that of an abutment of a percutaneous bone conduction hearing prosthesis.", "This is the case, for example, with respect to the transmission of vibrations from the bone conduction device 100 into the support 300 via connection of the bone conduction device 100 to the bone conduction device attachment portion 330.Additional features of the functionality of the bone conduction device attachment portion 330 will be described below.", "In the embodiments of FIGS.", "3A-C, the support 300 is used to support a bone conduction device so that output from a medical device, such as, for example, vibratory waves (also referred to herein as vibrations) may be directed into the skin (through, for example, the skin interface portions).", "As will be detailed further below, the support may be used to transmit other types of output generated by a device supported by the support.", "Such output may include electromagnetic waves, waves of a magnetic inductance field, etc.", "It is noted that in some embodiments, transmission of the aforementioned waves is performed where the path of wave transmission follows a path comprised substantially entirely of (including entirely of) physical contact between the support and/or or the device generating the support and the skin (which includes hair interposed between the skin).", "This as contrasted to, for example, speaker head phones which rely on air transmission to transmit sound to the outer ear.", "Any device, system or method that will permit a bone conduction device as detailed herein and in variations thereof to be attached to the support 300 so as to permit embodiments detailed herein and variations thereof to be practiced may be utilized in some embodiments.", "In an exemplary embodiment, the support 300 corresponds to a headset configured such that the center of gravity of the headset, during normal use, with and/or without bone conduction devices attached thereto, is located behind and, with respect to a vertical direction, at least one of about level with or below a location where vibrations transmitted from a bone conduction device supported by the headset are transmitted into skin of the recipient where the skin covers the mastoid bone behind an ear canal of the recipient.", "Such an exemplary support is depicted in FIG.", "3C, where center of gravity 370 is located as depicted.", "FIG.", "5 depicts bone conduction devices 100 removably attached to bone conduction device support 300, thereby forming a bone conduction device, herein prosthesis 500.As may be seen, two (2) bone conduction devices 100 are attached at locations on the support 300 such that the bone conduction devices 100 are located at substantially symmetrical locations.", "By substantially symmetrical, it is meant symmetrical with respect to a plane that bisects the device 300 through about the center of the segmented circle shape of the elongated structure 310 such that symmetrical portions of the elongated structure 310 would result.", "It is noted that while the support 300 described herein includes two bone conduction device attachment portions 330 fur respective attachment to two bone conduction devices 100, other embodiments may only include one or may include three or more bone conduction device attachment portions.", "Further while the two bone conduction device attachment portions 330 are presented such that they are positioned at symmetrical locations, in other embodiments the bone conduction device attachment portions 330 may not be so symmetrically positioned.", "In the same vein, while the skin interface portions 320 described herein are presented as being symmetrical, in other embodiments, skin interface portion 320 may not be symmetrical.", "Still further, while two skin interface portion 320 have been described as being included in the support 300, other embodiments may include only one skin interface portion 320 or may include three or more skin interface portions 320.The relationship between skin interface portions 320 and bone conduction devices 100 will now be described.", "In the embodiment of FIGS.", "3A to 5, the skin interface portions 320 are configured to transfer vibrations generated from the bone conduction devices from the respective bone conduction devices 100 in closest proximity thereto, into the support 300 and then into the skin of the recipient, after which those vibrations are transferred from the skin of the recipient into the mastoid bone of the recipient such that a hearing percept may be evoked as in a manner analogous to that which may be evoked via the percutaneous bone conduction device detailed above with respect to FIG.", "1 (except that skin is interposed between the mechanical path from the bone conduction device and the mastoid bone).", "Accordingly, in some embodiments, the clamping force supplied by the support 300 reacted through skin interface portions 320 in contact with the skin of the recipient is such that an effective amount of the vibrations generated by the bone conduction devices is transferred from the support 300 into the skin, the effective amount being sufficient to evoke the hearing percept.", "The embodiments of FIGS.", "3A to 5 are such that the bone conduction device attachment portions 330, and thus the bone conduction devices 100 when attached to support 300, are aligned/substantially aligned with the skin interface portions 320 and/or the distance between the bone conduction device attachment portions 330 and the skin interface portions 320 is a minimum/substantially a minimum.", "In other embodiments, the bone conduction device attachment portions 330 may be offset from the skin interface portions 320.This may be the case for one or two or three or more of the bone conduction device attachment portions 330 relative to the skin interface portions 320.In some embodiments, any location of the bone conduction device attachment portions 330 relative to the skin interface portions 320 may be utilized such that in embodiments detailed herein and variations thereof may be practiced.", "In an alternate embodiment, support 300 may be configured such that the support 300 does not include skin interface portions hut instead the support 300 is configured to attach to bone conduction devices 100 to which separate skin interface portion(s) are attached thereto.", "That is, vibrations generated by the bone conduction devices 100, at least those utilized to produce the hearing percept, are not transferred through the support 300 as would be the case in the embodiment depicted in FIG.", "5, but are instead transferred from the bone conduction device to those separate skin interface portions attached directly to the bone conduction device 100.Thus, support 300 might attach, for example, to the housing of the bone conduction devices without contacting the coupling apparatus 140/coupling 142.In an alternate embodiment, the support 300 may attach at the coupling apparatus 140, coupling 142, but may be vibrationally isolated therefrom.", "In such an embodiment, vibrations could travel through the coupling apparatus 140/coupling 142 and into the separate skin interface portions attached to the couplings 142, passing by the support 300.An exemplary embodiment of the separate skin interface portion may correspond to module 620 when removed from support 600, described further below.", "Accordingly, in some embodiments, support 300 is a support configured such that the vibrations generated by bone conduction devices 100 are transferred into the skin of the recipient at locations behind the ear canal of the recipient, where the skin covers the mastoid bone, regardless of whether a substantial amount (including any) of the vibrations generated by the bone conduction devices 100 travel through the support.", "Still, with regard to the embodiment of FIGS.", "3A to 5, in an exemplary embodiment, by way of example only and not by way of limitation, vibrations are generated from the respective bone conduction devices 100 which are transferred into the support 300 via the bone conduction device attachment portions 330.The vibrations then travel from the bone conduction device attachment portions 330 into structure of the support (e.g., into the skin interface portions 320).", "Again, embodiments of the support 300 may be such that the bone conduction devices 100 are offset from the skin interface portions such that the vibrations are transmitted through at least a portion of the structure 310 of the support 300 in the axial direction (i.e., paralleling the circumference of the structure 310).", "The vibrations travel from the skin interface portions 320 into the skin of the recipient, and then into the mastoid bone of the recipient.", "The vibrations then travel from the mastoid bone of the recipient directly to and/or through other tissue, to the cochlea of the recipient to evoke a hearing percept in the recipient.", "It is further noted that the aforementioned vibration path may also include vibrations traveling through a skin penetrating abutment connected to a bone fixture implanted into the mastoid bone and/or into a bone fixture or a plate implanted beneath the skin of the recipient at the mastoid bone.", "Such a scenario may exist, for example, where an abutment is being “rested” and vibrations travel through the skin parallel to the mastoid bone and into the abutment.", "Such a scenario may also exist in an embodiment where the support 300 is used with a passive transcutaneous bone conduction device such as that disclosed in U.S. patent application Ser.", "No.", "13/114,633.In such an exemplary embodiment, skin interface portions may be configured to transfer vibrations from the skin interface portions to the implantable component 350 of that application so as to evoke a hearing percept as disclosed therein.", "In this regard, in an exemplary embodiment, support 300 functions to support an external device 340 as disclosed therein proximate the implantable component 350.In this regard, support 300 may be further used to support an external device 440 at skin behind the ear canal and covering the mastoid bone as detailed in U.S. patent application Ser.", "No.", "13/114,633 to achieve the hearing percept functionality detailed in that application.", "Positioning of the skin interface portions at skin behind the ear canal and covering the mastoid bone will now be described with respect to embodiments that permit adjustment of the skin interface portions relative to other portions of the support.", "FIG.", "6 depicts an alternate embodiment of a bone conduction device support.", "Specifically, FIG.", "6 depicts a portion of a bone conduction device support 600 that includes a modularized skin interface portion 620 that is configured to be controllably moved relative to elongated structure 610 as will now be described.", "In the embodiment depicted in FIG.", "6, elongated structure 610 is an elongated piece of resiliently flexible metal having a substantially rectangular cross section lying on a plane normal to the direction of elongation of the structure 610.Module 620 includes a skin interface portion and a bone conduction device attachment portion 630.In an exemplary embodiment, module 620 may structurally correspond to the portions identified within the 320 bracket depicted in FIG.", "4.Accordingly, the skin interface portion of module 620 may correspond to or may be a variation thereof of those described herein (e.g., it may include an adhesive layer as detailed above) and bone conduction device attachment portion 630 may correspond to bone conduction device attachment portion 330 detailed above and/or variations thereof.", "Support 600 is configured to permit controlled adjustment of a location of module 620 along the length of the elongated structure 610.In the exemplary embodiment of FIG.", "6, support 600 is configured such that a friction fit and/or a positive interference fit is established between structure 610 and module 620.These fits enable module 620, and thus the skin interface portion thereof, to slide along the elongated structure 610 upon application of a sufficient force to module 620 to overcome the respective friction fit or interference fit.", "By friction fit, it is meant that a diameter of the module 620 at surfaces of the module 620 that interface with structure 610, in a relaxed state (e.g., not in contact with structure 610), are less than respective dimensions of surfaces of the elongated structure 610 that interface with module 620, in a relaxed state (e.g., not in contact with module 620), and/or visa-versa.", "Thus, a compressive force is applied by the module 620 to the structure 610 and a tensile force is applied by the structure 610 to the module 620.These forces are sufficient to generate sufficient friction to hold the module 620 in place relative to the structure 610 when a minimal amount of force is applied to module 620 relative to structure 610, but will permit module 620 to move relative to structure 610 upon application of a sufficient force such as may be applied by the hands of a user of bone conduction device support 600.", "(Some human factors issues relating to the bone conduction device supports detailed herein will be described in further detail below.)", "By positive interference fit, it is meant a fit where a portion of module 620 or a component of module 620 is located within a general outer profile of elongated structure 610, or vice-versa, as will be described in greater detail with respect to the embodiment of FIG.", "7A below.", "An exemplary embodiment of a positive interference fit may include a ratchet mechanism.", "An exemplary ratchet mechanism that may be used with module 620 includes an elastically deformable tooth that is configured to extend into one of a plurality of grooves located on the outer or inner surface (relative to the head of the recipient) of structure 610.This tooth is of sufficient rigidity to ensure that the module 620 remains fixed in a given location along the structure 610 under the application of a minimal force to module 620, but upon the application of sufficient force to module 620, the tooth elastically deforms (or a support of the tooth elastically deforms) to permit the tooth to be removed from the given groove in structure 610, thereby permitting module 620 to be moved along structure 610 to a desired location where the tooth fits into a new groove.", "The force required to deform the tooth (or the support) is such that the module 620 will remain at a desired location along structure 610 until the recipient or other user of the support 600 affirmatively attempts to change the location of module 620 relative to structure 610.In an alternate embodiment, a positive interference includes, for example, a bolt supported by module 620 that may be screwed into a hole of a series of holes in structure 610, or visa versa.", "In this regard, an alternate embodiment of a friction fit includes a bolt supported by module 620 that may be screwed down onto structure 610 with a sufficient force to prevent module 620 from sliding relative to structure 610, By unscrewing the bolt, the friction created by the friction fit may be adjusted so that the module 620 may slide relative to the structure 610.Any device, system or method which will permit module 620, and thus skin interface portion, of the bone conduction device support to be adjusted in accordance with the embodiments herein and variations thereof may be used in some embodiments.", "It is noted that this is also the case with respect to other portions of the support that move relative to one another, as detailed herein and variations thereof.", "As may be seen, the embodiment of FIG.", "6 includes a foam cushion 650 located at the end of elongated structure 610.It is noted that while FIG.", "6 depicts a portion of one side of a support 600, the configuration depicted in FIG.", "6 may be also found on the other side of the exemplary support 600.However, in other embodiments, the configuration in FIG.", "6 may be unique to one side of the support 600, the other side having a module 620 and/or a skin interface portion 320 being fixed relative to a given location with respect to structure 610.Alternatively or in addition to this, the other side of support 600 may not have a skin interface portion/may have a different skin interface portion from that on the other side and/or may not have a module 620.FIG.", "7A depicts a portion of an exemplary embodiment of a bone conduction device support 700a where the clamping force applied to the recipient's head is established by a structure comprising a plurality of sub-structures, As may be seen, support 700 includes structure 710a, a portion of which is depicted in FIG.", "7A, that in turn includes substructure 711 and substructure 713.Substructure 711 and substructure 713 have cross-sectional configurations, on planes normal to the direction of extension of structure 710a, that are substantially identical in configuration to each other.", "Substructure 711 and substructure 713 are connected to one another via substructure 715.Substructure 715 has overall outer diameters which are less than respective diameters of substructure 711 and 713.As may be seen, substructure 715 includes a plurality of grooves 717 that are located in substructure 715.The embodiment depicted in FIG.", "7A is an embodiment where substructure 715 is fixedly mounted to substructure 711 and substructure 713 telescopes with respect to substructure 715, thus permitting the location of substructure 711 to be varied relative to substructure 713.In this regard, substructure 715 is a male component that extends into substructure 713, which corresponds to a female component.", "It is noted that while the embodiment of FIG.", "7A includes two telescoping sections (one of which is not shown), embodiments may be practiced where there is only a single telescoping section (e.g., positioned such that it is located about the back of the head or neck of the recipient) or where there are three or more telescoping sections.", "Such embodiments may have a sub-structure that telescopes into another sub-structure which further telescopes into yet another sub-structure, and so on.", "The position of substructure 713, relative to substructure 715 and thus substructure 711, is maintained via a positive interference fit in the form of a ratchet system.", "Grooves 717 of substructure 715 permit a tooth or a plurality of teeth (not shown) attached to substructure 713 to elastically fit into those grooves, thereby maintaining a position of substructure 711 relative to substructure 713 while also permitting the location of substructure 711 to be varied with respect to that of substructure 713 in accordance with the teachings above with respect to an interference fit.", "In an exemplary embodiment, a recipient or other user of the support 700a holds substructure 713 in one hand and holds substructure 711 in his or her other hand and applies a compressive force and/or a tensile force to the structure 700a to change the position of substructure 711 to move it towards or away from, respectively, substructure 713.It is noted that in an alternate embodiment, substructure 715 could be originally connected to substructure 713 and substructure 711 could telescope with respect to substructure 715, or both substructure 711 and substructure 713 could telescope with respect to substructure 715.Any device, system or method that will permit the location of substructure 711 to be changed relative to substructure 713, or vice versa, while also permitting the locations of those structures to be maintained as detailed herein and variations thereof, may be used in some embodiments.", "From FIG.", "7A, it can be understood that moving the position of substructure 711 changes the position of skin interface portion 720 and pad 750.Thus, the position of skin interface portion 720 relative to the recipient may be adjusted such that the position of skin interface portion 720 will correspond to a location behind the ear canal of the recipient on skin covering the mastoid bone of the recipient.", "In the embodiment of FIG.", "7A, skin interface portion 720 may be modularized as detailed herein and variations thereof, with element 721 permitting the modularized skin interface portion 720 to be offset from the clamping structure of the bone conduction device support 700a, as shown.", "The embodiment of FIG.", "7A depicts a support portion 721 located between substructure 711 and skin interface portion 720.Support portion 721 may be configured to vibrationally isolate skin interface portion 720 from the remainder of the support 700a.", "In an exemplary embodiment, bone conduction device attachment portion 730 is located in skin interface portion 720 and is not connected to substructure 711 and support portion 721.For example, a bore may extend through substructure 711 and through support portion 721 to provide clearance between the coupling apparatus 140 of bone conduction device 100.In an exemplary embodiment applicable to all embodiments detailed herein and variations thereof, support portion 721 permits the distance between skin interface portion 720 and the rest of the structure of support 700a to be controllably adjusted.", "Thus, groove 717 of the interference fit permit axial adjustment of the location of the skin interface portion 720 while support portion 721 permits the radial adjustment of the location of the skin interface portion 721.In the embodiments depicted in FIG.", "7A, support portion 721 may include a screw type mechanism that permits skin interface portion 720 to be screwed inward towards substructure 711 or outward from substructure 711 thereby changing the distance between skin interface portion 720 and substructure 711.Other embodiments may use other devices, such as, for example, a rack and pinion system to change the distance of skin interface portion 720 relative to substructure 711.Any device, system or method that may be utilized to change the radial distance of skin interface portion 720 relative to substructure 711 may be used to practice some embodiments herein and variations thereof.", "It is noted that in embodiments where the skin interface portion and/or other components of the support are adjustable, markings may be included on the support that indicate the extent of adjustment from a baseline.", "For example, with respect to FIG.", "6, element 610 may include markings to indicate the position of module 620.Still further by example, with respect to FIG.", "7A, grooves 717 may be marked so as to indicate position of substructure 711 and/or substructure 713 relative to substructure 715.Such an embodiment may have utility in the event that a recipient accidently adjusts the position of the module 620 or substructure 713 or 711, thus permitting the recipient to reposition the module or substructure.", "FIG.", "7B depicts another embodiment of a bone conduction device support 700b.", "Particularly bone conduction device support 700b includes a structure, a portion of which is shown in FIG.", "7B as structure 710b, that includes substructure 719 (again a portion of which is shown in FIG.", "7B) and substructure 723.Substructure 723 articulates with respect to substructure 719.Particularly, hinge 725 permits substructure 723 to articulate relative to substructure 719 and/or visa-versa.", "Hinge 725 may be in the form of a barrel hinge, a pivot hinge, a piano hinge or any other type of hinge.", "The hinge pin of these respective hinges may be fixed to substructure 723 or substructure 719 or both in the case of a multi-hinge pin hinge 725.In an alternate embodiment, hinge 725 is established by making a portion that is integral to substructure 723 and/or substructure 719 more elastically deformable than other portions of substructure 723 and/or substructure 719.Alternatively, the hinge portion 725 may simply be a portion that is as elastically deformable as the other portions, and basic human factors dictate that this portion is the portion that will hinge.", "Any device, system or method that will permit substructure 723 to articulate with respect to substructure 719 may be practiced with at least some embodiments detailed herein and variations thereof.", "In an embodiment utilizing the articulating substructure 723, the location of skin interface portion 320 and an end 701 of substructure 723, relative to the rest of the support, 700b, may be changed to better conform to the head of a recipient relative to the conformance obtained without the articulating ability of the substructures.", "While the embodiment depicted in FIG.", "7B depicts a substructure 723 that articulates in the general plane on which the structure of the support extends, other embodiments may permit substructure 723 to articulate in and out of that plane, alternatively or in addition to the depicted articulation.", "It will be seen from FIG.", "7B, in some embodiments, substructure 723 can only articulate to a certain angle relative to substructure 719 because a portion of the bone conduction device 100 attached at attachment point 330 may contact substructure 719.In this regard, the articulation depicted in FIG.", "7B may be considered exaggerated and thus not to scale in some embodiments.", "However in other embodiments the location of bone conduction device attachment portion 330 may be such that there is clearance between the bone conduction device 100 and the rest of the Support 700.In an exemplary embodiment of the bone conduction device support 700b of FIG.", "7B and/or variations thereof, substructure 723 and its opposite substructure on the other side of the bone conduction device 700b are utilized to transmit the clamping force generated by the support 700b to the head of the recipient either at the location of the skin interface portion 320 substantially entirely (including entirely) or at the skin interface portion 320 and the end 701 of substructure 723 (or to a pad that may be located at the end of substructure 701).", "Alternatively, this clamping force may be distributed at points between the end 701 and the location of skin interface portion 320.It is noted that in some embodiments, any of the features of the various supports detailed herein may be combined with any other of the features of the various supports detailed herein.", "By way of example, a support may include the telescoping feature of the embodiment of FIG.", "7A along with the hinge feature of the embodiment of FIG.", "7B.", "As noted above, embodiments detailed herein and variations thereof may be applicable to support devices for other types of hearing prostheses and/or other types of medical devices.", "By way of example and not by way of limitation, one or more of all of the supports detailed herein and/or variations thereof may be applicable to support an external component of a cochlear implant and or an external component of an active transcutaneous bone conduction device.", "Such an external component may include a telecoil.", "The support may be configured to position the telecoil at a location behind the ear canal of the recipient on skin of the recipient covering the mastoid bone at a location proximate to an implantable component of the cochlear implant.", "This implantable component/a portion of the implantable component may include a telecoil as well.", "Thus, the supports detailed herein and/or variations thereof may be utilized to position an external telecoil proximate to and in alignment with the implanted telecoil.", "Such an embodiment may be utilized, by way of example, in a scenario where the implanted magnet is unfeasible and/or where an implanted magnet has otherwise failed for a given reason, where the implanted magnet would otherwise be used to align and/or hold the external component against the skin of the recipient.", "Embodiments of the supports detailed herein and/or variations thereof may be utilized in instances where recipients are evaluating bone conduction hearing prosthesis, either in a unilateral and/or a bilateral and/or multilateral configuration.", "Such supports may be utilized in the case of recipients awaiting surgery for a percutaneous bone conduction implant and/or a transcutaneous bone conduction implant.", "Such supports may be utilized by way of example for children whose mastoid bones and/or other bones are not of sufficient thickness and/or sufficient strength to receive the implanted portion of a bone conduction prostheses.", "Indeed in an exemplary embodiment the supports detailed herein and/or variations thereof may be utilized with adults or children who have developed an infection with respect to the implanted portion of the bone conduction device and/or who are simply in need of resting the implant abutment.", "Some of the embodiments detailed herein and variations thereof may be utilized to provide a bilateral bone conduction hearing prosthesis.", "Thus, such a support may be utilized to test (evaluate) a bilateral hearing prosthesis.", "Such may be done, in some embodiments, without any additional parts or connectors to be added to a given support.", "In this regard, while the supports detailed herein have been detailed in terms of having the ability to connect two or more bone conduction devices thereto (e.g., permitting the establishment of a bilateral bone conduction hearing prosthesis), it is noted that in some embodiments, even though the supports have two or more bone conduction device attachment portions, such supports may be utilized with only one bone conduction device attached thereto thus permitting the same support to be utilized in a unilateral configuration and/or a bilateral configuration.", "An embodiment of the supports detailed herein and variations thereof are sized and dimensioned and otherwise configured to permit use of a given support on a child and an adult without any specific adjustments and/or any clinical measurement of the recipient's head.", "That is, a given support may be issued to a recipient irrespective of whether that recipient is a child or an adult (i.e., irrespective of the size of the child's head/development of the organs of the recipient's head), where the recipient himself or herself or a semi-trained or even untrained person may sufficiently adjust the support so as to obtain a sufficient efficacy of the hearing prosthesis vis-à-vis a hearing percept obtained by a bone conduction device.", "That is, because the supports detailed herein and variations thereof permit adjustment of the skin interface location and/or permit the entire system to be moved relative to the recipient's head so as to position a given skin interface portion at a desired location, specific training and/or skills may not be needed to utilize some embodiments.", "Indeed, in some embodiments, a trial and error approach can be recommended for recipients, because the adjustments to the support 300 are relatively easily made compared to other support systems for other bone conduction hearing prostheses.", "At least some embodiments of the supports detailed herein and variations thereof are sized and dimensioned and otherwise configured to conform to the head of a statistically average (mean or median) human being in a given population.", "In an exemplary embodiment, there are supports detailed herein and variations thereof that are sized and dimensioned and otherwise configured to conform to the head of a statistically average sized human as well as the head of a human being falling within one-half of a standard deviation larger and/or smaller from the statistically average sized human.", "In yet other embodiments, such supports are sized and dimensioned and otherwise configured to conform to the head of a statistically average sized human as well as the head of a human having a head size falling within one standard deviation larger and/or smaller than the average head size.", "In exemplary embodiments, there is a support as detailed herein and/or variations thereof that is sized, dimensioned, and/or otherwise configured to conform to a statistically average size head of a human being of a given population and a head larger and/or smaller than that that falls within about 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9 and 3.0 and/or more standard deviations from the statistically sized average, without additional parts and/or without the need to remove parts (i.e., only adjustments are made as detailed herein) With respect to a given population, such a population may include, in some embodiments, the population of the entire world.", "In other embodiments, it may be directed to an ethnic populace such as for example Caucasians, Mongoloids and/or Negroids.", "In yet other embodiments, the aforementioned population may be limited to a geographic region such as North America, South America, Asia, Europe, Africa and/or Australia.", "In yet other embodiments, the population may be limited to citizens and/or residents of specific countries, such as the United States, Australia, Canada, the United.", "Kingdom, France, Germany, Spain, Sweden, Italy, China, India, Japan, Mexico, etc.", "The population may be limited to adults, may be limited to children, may be limited to adolescents or may be limited to the combination thereof (e.g.", "adolescents and adults, children and adolescents).", "In some embodiments, the population may be limited to humans above a certain age, such as, for example above one year old, above 18 months old, above 2 years old, above 2.5 years old, above 3 years old, above 3.5 years old, above 4 years old, above 4.5 years old, above 5 years old, above 5.5 years old, above 6 years old, above 6.5 years old, above 7 years old, above 7.5 years old, above 8 years old, above 9 years old, above 10 years old, above 11 years old, above 12 years old, above 13 years old, above 14 years old, above 15 years old, and or above 16 years old.", "It is noted that the just described examples of populations, in some embodiments, are combined in any variety.", "By way of example, an exemplary population may include Caucasians having U.S. citizenship that are older than 6 years old.", "It is also noted that the aforementioned populations may be bifurcated between male and female and the above mentioned populations may be further bifurcated into subpopulations (e.g.", "non-Hispanic Caucasians, Hispanic Caucasians).", "Any population group may be utilized in some embodiments detailed herein.", "At least some of the embodiments of the supports detailed herein and variations thereof are configured to provide a clamping force to one or more of the aforementioned populations and/or combinations and/or sub-combinations thereof of recipients such that the support retained relative to the head of the recipient is retained at substantially the same place on the recipient being subjected to an acceleration in the horizontal and/or vertical direction (up or down) and/or in vectors between such that the medical device supported by the support maintains efficacy.", "By way of example only and not by way of limitation, an exemplary support may retain itself (and the medical device it supports) to the head of the recipient without substantially moving (where substantially moving results in a significant degradation of the performance of the hearing prosthesis of which the support is a part) when subjected to an upward and/or downward and/or horizontal forward and/or horizontal backward acceleration that corresponds to 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.5, 3.0, 3.5, 4.0, 5.0, 6.0, 7.0, 8.0, 9.0 and/or 10.0 G-forces, at least some of which may be experienced in the event of the recipient standing from a seated position and/or visa-versa, the recipient walking and/or running up or down stairs.", "Such G-forces may be experienced, for example, where the recipient is subjected to even greater accelerations, such as may be obtained in the event of the recipient jumping up or down (which may be experienced while running, playing basketball, jumping from a jungle gym, etc.).", "At least in some embodiments of the present invention, where the support arches around the back of the recipient's head passing through a location, in the vertical direction, between the head and the shoulders of the recipients/in the neck region (vertically speaking) of the recipient, improved cosmetic results are obtained vis-à-vis supports that arch about the top of the head.", "For example, because the support is not worn across the entire head, such as in the case with headphones and the like, the support is less visible than other types of supports used for other devices and or devices detailed herein.", "In an exemplary embodiment, the supports detailed herein and variations thereof may be configured such that the support maintains a position of the device supported thereon to permit efficacious functionality of the device vis-à-vis the recipient without a component extending about a top of the head.", "Such an embodiment may be configured to maintain its position relative to the recipient after the recipient is subjected to 2G-forces in the vertical direction.", "It is noted that the aforementioned performance features, vis-à-vis retention when subjected to G-forces, are achieved without ancillary support of the support (e.g., the recipient is not holding the support to his or her head, etc.", "), By normal use, it is meant use as prescribed, for example, by an audiologist, a surgeon, the manufacturer of the device as approved by a major underwriting entity (e.g., Underwriters Laboratory in the U.S.), etc.", "It is noted that in the embodiments of the supports detailed herein having adjustable components such that, for example, the location of the skin interface portion may be adjusted relative to the rest of the support, such adjustment permits at least in some embodiments the supports to be applicable to the above mentioned populations without reconstructing the support/adding components/removing components from the support, Thus, in an exemplary embodiment there is a self-contained support that may be issued to a wide range of populations of recipients without medical measurement of the recipient's head.", "That is, an exact size of a recipient's head need not be determined.", "In some embodiments of the supports detailed herein and variations thereof, sides of the support may be labeled to indicate which sides of the support should be positioned relative to a side of a recipient.", "Such labeling may be in words and/or in symbols (e.g., L, R, sides of the head depicted in a pictorial, etc.).", "In some embodiments, the supports detailed herein and variations thereof are configured to be single use products and/or disposable products.", "That is, at least some supports detailed herein and variations thereof are configured such that they are to be disposed of after utilization of the support by a recipient is completed.", "That is, such supports need not be shared between different recipients.", "Such an exemplary embodiment reduces the need for enhanced cleaning of such supports as might otherwise be the case for shared supports.", "FIG.", "8 presents an exemplary flow chart 800 representing, by way of example only and not by way of limitation, an exemplary method of utilizing the supports detailed herein and variations thereof.", "At step 810, a practitioner in the bone conduction hearing prostheses arts (e.g., an audiologist, an audiological surgeon, a nurse, etc.)", "provides a recipient with a bone conduction hearing prosthesis including a support as detailed herein and variations thereof and one or more bone conduction devices supported thereby.", "It is noted that the term “providing” as used in this method includes both obtaining the prosthesis and directly giving the prosthesis to the recipient and enabling the recipient to obtain the prosthesis on his or her own (e.g., providing the recipient with a prescription for the prosthesis).", "At step 820, the practitioner directs the recipient to wear the first bone conduction hearing prosthesis during every day (normal) usage such the hearing prosthesis extends around a back of a head of the recipient without extending all the way in front of the head of the recipient and without extending all the way over a top of the head of the recipient.", "At step 830, the practitioner evaluates the efficacy of the hearing prosthesis after at least two days of the recipient wearing and using the hearing prosthesis for substantial portions of the two days as directed.", "An exemplary method further includes repeating some or all of steps 810 for a number of different recipients, where the respective provided bone conduction device hearing prostheses are of a design that is duplicative.", "Further, in practicing such a method, such a method may include providing such hearing prostheses to recipients having different sized heads.", "By way of example, the recipients of a first group of, say, 10 recipients, may be adult males having heads with circumferences in a horizontal plane bisecting an opening of an ear canal of the recipient of a first value or more.", "Further by way of example, the recipients of a second group may be of, say, 10 recipients, may be child males having heads with circumferences in a horizontal plane bisecting an opening of an ear canal of the recipient of a second value or less, where the second value is about two-thirds the value of the first value.", "Because of at least some features as detailed herein and variations thereof of at least some embodiments of the supports detailed herein and variations thereof, the same hearing prosthesis may be provided to both children and adults of substantially different head sizes.", "While various embodiments of the present invention have been described above, it should be understood that they have been presented by way of example only, and not limitation.", "It will be apparent to persons skilled in the relevant art that various changes in form and detail can be made therein without departing from the spirit and scope of the invention.", "Thus, the breadth and scope of the present invention should not be limited by any of the above-described exemplary embodiments, but should be defined only in accordance with the following claims and their equivalents." ] ]
Patent_15875960
[ [ "TRANSFORMABLE ORTHOPEDIC BRACE FOR INJURY PREVENTION", "An orthopedic brace for preventing injury to a wearer including a body having a series of liquid filled regions, the body having a first more flexible state wherein the liquid filled regions contain a liquid material and a second more rigid state wherein the liquid within the regions is hardened to a second harder state, the body transformable from the first state to the second state upon receiving a force which exceeds a predetermined value.", "A chemical reaction or an isothermal process can cause the phase change." ], [ "1.An orthopedic brace for preventing injury to a wearer comprising a body having a series of liquid filled regions, the body having a first more flexible state wherein the liquid filled regions contain a liquid material and a second more rigid state wherein the liquid within the regions is hardened to a second harder state, the body transformable from the first state to the second state upon receiving a force which exceeds a predetermined value.", "2-20.", "(canceled)" ], [ "<SOH> BACKGROUND <EOH>This application claims the benefit of provisional application 61/940,406, filed Feb. 15, 2014, the entire contents of which are incorporated herein by reference.", "cross-reference-to-related-applications description=\"Cross Reference To Related Applications\" end=\"tail\"?" ], [ "<SOH> SUMMARY <EOH>The present invention provides a brace having a liquid filled material that is transformed from a first soft state to a hardened second state upon application of a force exceeding a threshold force.", "The force can be internal or external.", "In one aspect, the present invention provides an orthopedic brace for preventing injury to the wearer comprising a body having a series of liquid filled regions, the body having a first more flexible state wherein the liquid filled regions contain a liquid material and a second more rigid state wherein the liquid within the regions is hardened to a second harder state.", "The body is transformable from the first state to the second state upon receiving a force which exceeds a predetermined value.", "The force can be an external force or an internal force applied to the body.", "In one embodiment, the liquid filled regions are enclosed compartments arranged in a substantially vertical orientation.", "In another embodiment, the liquid filled elements are enclosed compartments arranged in a substantially horizontal orientation.", "In another embodiment, the liquid filled elements are compartments arranged in a substantially diagonal orientation.", "In some embodiments, at least one sensor is positioned in or on the body to detect the force applied to the body.", "The sensor can measure the applied force and send a signal to activate the liquid if the force exceeds the predetermined value In some embodiments, the liquid is transformed to a more rigid state by a chemical reaction effected by mixing with a second liquid.", "In other embodiments, the liquid is transformed to a more rigid state by an isothermal process, i.e., effected by changing the temperature of the liquid.", "In some embodiments, a second liquid is pumped into the liquid filled compartments to cause hardening of the liquid.", "In other embodiments, the second liquid is mixed with the liquid in the compartments by rupturing of a membrane containing the second liquid.", "In accordance with another aspect, the present invention provides an orthopedic brace for preventing injury to a joint of a wearer, the brace comprising a body having a series of liquid filled regions positioned internal of an outer surface of the body.", "The body has a first more flexible state wherein the liquid filled regions contain a liquid material and a second more rigid state wherein the liquid within the regions undergoes a phase transformation to a solid state to transform the flexible brace to a rigid protective device to withstand further impact on the joint of a wearer of the brace.", "The body is transformable from the first state to the second state upon receiving a force which exceeds a preset value.", "At least one sensor is carried by the body for detecting and measuring at least one of an external or an internal force applied to the brace and determining if such force exceeds the preset value.", "The at least one sensor sends a first signal to effect transformation of the liquid to the solid state if the force exceeds the preset value and refrains from sending the first signal if the force does not exceed a preset value so that the liquid is maintained in its liquid state and the brace is not transformed to the more rigid state to maintain the mobility of the wearer.", "In some embodiments, the at least one sensor comprises a plurality of sensors carried by the body and spaced apart to detect impact to various regions of the body.", "In some embodiments, the phase change is an isothermal process; in other embodiments, the phase change is caused by a chemical reaction.", "In some embodiments, the chemical reaction is effected by mixing of a second liquid within the liquid filled regions.", "In accordance with another aspect of the present invention, a method for protecting a joint of the wearer from an excessive force applied to the joint is provided, the method comprising: providing a brace having a liquid filled section; measuring an external or an internal force applied to the brace; comparing the applied external or internal force to a predetermined value; and transforming the liquid filled section to a solid filled section to rigidify the brace if the measured applied force exceeds the predetermined value.", "In some embodiments, the liquid filled section includes a plurality of compartments containing the liquid therein.", "In some embodiments, the brace includes a sensor, and the sensor measures the applied external or internal force.", "In some embodiments, the sensor sends a signal to an activator if the applied force exceeds a predetermined value." ], [ "BACKGROUND This application claims the benefit of provisional application 61/940,406, filed Feb. 15, 2014, the entire contents of which are incorporated herein by reference.", "TECHNICAL FIELD This application relates to an orthopedic brace for injury prevention and more particularly to an orthopedic brace that can be transformed from a softer to harder state to prevent injury.", "BACKGROUND OF RELATED ART Braces for use to protect the knee, ankle or other parts of the body are known.", "These braces are typically composed of a rigid material designed to prevent injury to the knee or ankle upon impact by an external force.", "The braces are also designed to prevent injury caused by an internal force such as severe or sudden knee or ankle rotation.", "That is, since external or internal forces cause abnormal stress or strain on ligaments and/or joints, and can lead to tissue tear or rupture, or other damage, these prior braces are designed to provide a rigid support to limit such damage.", "Although known rigid braces can protect the knee or ankle, they severely inhibit motion.", "They are also stiff and heavy and therefore uncomfortable to wear.", "Consequently, people oftentimes will not wear such uncomfortable mobile affecting braces, and accept the risk of injury.", "Additionally, oftentimes it is only necessary to have such support if the knee or ankle is subject to excessive stress, but not required during normal activity.", "However since the user does not know when such stress might occur, the user is forced to wear the cumbersome brace at all times in anticipation of such excessive force and thus unnecessarily has his or her mobility reduced.", "Alternatively, due to the reduced mobility and discomfort, the user might decide not to wear the brace, taking the risk of severe injury if the knee or ankle is impacted without the support of the brace.", "For athletes the choice is even more difficult as they need to choose between a) not wearing a brace and subjecting themselves to risk of injury, and potentially career ending injury, or b) wearing a motion restricting brace which adversely affects their athletic performance.", "In some instances, because of the rigid brace, the athlete may not even be able to participate in the athletic activity.", "Therefore, it would be advantageous to provide a brace that is sufficiently lightweight and flexible so as to be comfortable to the user and not adversely affect motion and mobility, while still providing maximum protection to the knee or ankle to prevent injury if subject to excessive force.", "SUMMARY The present invention provides a brace having a liquid filled material that is transformed from a first soft state to a hardened second state upon application of a force exceeding a threshold force.", "The force can be internal or external.", "In one aspect, the present invention provides an orthopedic brace for preventing injury to the wearer comprising a body having a series of liquid filled regions, the body having a first more flexible state wherein the liquid filled regions contain a liquid material and a second more rigid state wherein the liquid within the regions is hardened to a second harder state.", "The body is transformable from the first state to the second state upon receiving a force which exceeds a predetermined value.", "The force can be an external force or an internal force applied to the body.", "In one embodiment, the liquid filled regions are enclosed compartments arranged in a substantially vertical orientation.", "In another embodiment, the liquid filled elements are enclosed compartments arranged in a substantially horizontal orientation.", "In another embodiment, the liquid filled elements are compartments arranged in a substantially diagonal orientation.", "In some embodiments, at least one sensor is positioned in or on the body to detect the force applied to the body.", "The sensor can measure the applied force and send a signal to activate the liquid if the force exceeds the predetermined value In some embodiments, the liquid is transformed to a more rigid state by a chemical reaction effected by mixing with a second liquid.", "In other embodiments, the liquid is transformed to a more rigid state by an isothermal process, i.e., effected by changing the temperature of the liquid.", "In some embodiments, a second liquid is pumped into the liquid filled compartments to cause hardening of the liquid.", "In other embodiments, the second liquid is mixed with the liquid in the compartments by rupturing of a membrane containing the second liquid.", "In accordance with another aspect, the present invention provides an orthopedic brace for preventing injury to a joint of a wearer, the brace comprising a body having a series of liquid filled regions positioned internal of an outer surface of the body.", "The body has a first more flexible state wherein the liquid filled regions contain a liquid material and a second more rigid state wherein the liquid within the regions undergoes a phase transformation to a solid state to transform the flexible brace to a rigid protective device to withstand further impact on the joint of a wearer of the brace.", "The body is transformable from the first state to the second state upon receiving a force which exceeds a preset value.", "At least one sensor is carried by the body for detecting and measuring at least one of an external or an internal force applied to the brace and determining if such force exceeds the preset value.", "The at least one sensor sends a first signal to effect transformation of the liquid to the solid state if the force exceeds the preset value and refrains from sending the first signal if the force does not exceed a preset value so that the liquid is maintained in its liquid state and the brace is not transformed to the more rigid state to maintain the mobility of the wearer.", "In some embodiments, the at least one sensor comprises a plurality of sensors carried by the body and spaced apart to detect impact to various regions of the body.", "In some embodiments, the phase change is an isothermal process; in other embodiments, the phase change is caused by a chemical reaction.", "In some embodiments, the chemical reaction is effected by mixing of a second liquid within the liquid filled regions.", "In accordance with another aspect of the present invention, a method for protecting a joint of the wearer from an excessive force applied to the joint is provided, the method comprising: providing a brace having a liquid filled section; measuring an external or an internal force applied to the brace; comparing the applied external or internal force to a predetermined value; and transforming the liquid filled section to a solid filled section to rigidify the brace if the measured applied force exceeds the predetermined value.", "In some embodiments, the liquid filled section includes a plurality of compartments containing the liquid therein.", "In some embodiments, the brace includes a sensor, and the sensor measures the applied external or internal force.", "In some embodiments, the sensor sends a signal to an activator if the applied force exceeds a predetermined value.", "BRIEF DESCRIPTION OF THE DRAWINGS Preferred embodiment(s) of the present disclosure are described herein with reference to the drawings wherein: FIG.", "1A is a side perspective view of a knee brace of a first embodiment of the present invention, shown in a flexible state and with the liquid columns (compartments) positioned in a substantially vertical orientation; FIG.", "1B is a side perspective view similar to FIG.", "1A showing the knee brace in the hardened state; FIG.", "1C is a cross-sectional view taken along line 1C-1C of FIG.", "1A; FIG.", "2 is a side perspective view of the knee brace of FIG.", "1A shown positioned on a person's knee; FIG.", "3A is a front view of an alternate embodiment of the knee brace of the present invention having the liquid columns positioned in a substantially diagonal orientation, and shown in the flexible state; FIG.", "3B is a front view similar to FIG.", "3A showing the knee brace in the hardened state; FIG.", "4A is a front view of another alternate embodiment of the knee brace of the present invention having the liquid columns positioned in a substantially horizontal orientation, and shown in the flexible state; FIG.", "4B is a front view similar to FIG.", "4A showing the knee brace in the hardened state; FIGS.", "5A and 5B show respectively a rotation force and a direct force applied to the knee causing the brace to transform to a hardened state, and further showing the sensors in phantom lines which are omitted from FIGS.", "1-4B for clarity; FIG.", "6 is a side perspective view of an alternate embodiment of the knee brace of the present invention; FIG.", "7 is a side perspective view of another alternate embodiment of the knee brace of the present invention; FIG.", "8 is a side perspective view of another alternate embodiment of the knee brace of the present invention; FIG.", "9A is a close up view of a portion of the one of the compartments of the brace of FIG.", "8 showing a force applied to the brace; FIG.", "9B is a view similar to FIG.", "9A showing rupturing of the internal wall to cause mixing of a second material with the fluid in the compartment; FIG.", "9C is a view similar to FIG.", "9A showing the fluid transformed to a hardened state within the compartment; FIG.", "10 is a perspective view of another alternate embodiment of the knee brace of the present invention; FIG.", "11A is a close up view of the one of the compartments of FIG.", "10, and showing schematically the sensor and the container for storing a second material; FIG.", "11B is a view similar to FIG.", "11A showing the liquid in the compartment transformed to a harder material as a result of mixing with the second material; FIG.", "12 is a perspective view of an ankle brace of the present invention, shown in a flexible state and with the liquid columns (compartments) positioned in a substantially vertical orientation; FIG.", "13A is a perspective view of the ankle brace of FIG.", "12 shown on a person's ankle in a flexible state; FIG.", "13B is a perspective view similar to FIG.", "12 showing the ankle brace in the hardened state; and FIG.", "14 is a flow chart illustrating the use of the knee brace of the present invention.", "DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS Referring now in detail to the drawings where like reference numerals identify similar or like components throughout the several views, several different embodiments of the orthopedic braces of the present invention are described herein.", "The braces of the present invention are designed to be placed over the joint, e.g., ankle or knee, in a flexible state, and maintained in such state.", "The brace remains in the flexible state until it receives a sufficient impact, at which point it transforms to a more rigid state to protect the joint.", "This is achieved by a transformation of the liquid within the brace to a solid state.", "Various ways to cause the phase change from liquid to solid are disclosed herein by way of example, although other ways to achieve such phase transformation can be utilized.", "The braces include liquid contained in columns or compartments which provide flexibility to the brace so as not to inhibit the wearer's mobility.", "When the brace is transformed to the hardened state, the columns form a rigid structure which thereby protects the joint.", "Thus, automatically, the brace is transformed from a flexible brace in which the wearer's motion and mobility are not affected so the wearer can participate uninhibited/unrestrained in activities, including athletic activities, to a rigid state which effectively “locks” the brace and limits movement/motion, thus protecting the joint.", "As can be appreciated, the present invention therefore provides a protective rigid brace on an automatic as needed basis.", "Note that where there are multiple identical components in the particular Figure, e.g., sensors, compartments, only a few are labeled for clarity.", "Turning now to a first embodiment of the knee brace of the present invention, and with reference to FIGS.", "1A-2, the knee brace is designated generally by reference numeral 10 and includes a plurality of columns or compartments 12 embedded in the wall of the brace 10 between an outer wall 14 and an inner wall 16.Contained within the columns 12 is a liquid 18.The liquid is preferably a liquid metal.", "One type of metal that can be utilized is gallium which undergoes a phase transformation in response to temperature change.", "Other metals are also contemplated.", "Alternatively, the liquid can be a polymer or plastic which undergoes a phase transformation upon temperature change, provided the hardened state of such material is sufficient to protect the knee.", "As an alternative to temperature change to effect transformation from a liquid to a solid, chemical reactions are also contemplated such as by impact or as a result of the mixing of two liquids.", "These are discussed in more detail below.", "In the liquid state, the brace 10 remains flexible so as to not adversely affect mobility of the wearer.", "The columns 12 are shown extending substantially vertically, preferably extending the entire length, or substantially the entire length of the brace 10.Alternatively, the columns can extend in other orientations such as in a substantially diagonal orientation as in brace 40 of FIGS.", "3A-3B or in a substantially horizontal orientation as in brace 60 of FIGS.", "4A-4B.", "FIG.", "1A illustrates the columns 12 filled with liquid in a liquid state to maintain the flexibility of the brace 10, the columns sealed to keep the liquid within the individual compartments.", "Likewise, FIG.", "3A illustrates the sealed columns 42 filled with liquid 44 in a liquid state to maintain the flexibility of the brace 40 and FIG.", "4A illustrates the sealed columns 62 filled with liquid 64 in a liquid state to maintain the flexibility of the brace 60.As shown, preferably the columns extend along or across the entire region of the brace so that the entire knee and adjacent regions are protected.", "However, it is also contemplated that the columns can extend less than the entire length or provided only in certain regions of the brace so that only select regions of the brace are solidified.", "Additionally, the columns 12, 42, and 62 are shown having a width 15, 45, and 65, respectively.", "However, it is also contemplated that the columns can have a shorter width, thereby enabling more columns to be provided, or have a wider width, providing fewer columns.", "Further, the columns need not be of uniform width, but can have varying width.", "Such varying width can provide regions of differing hardness to accommodate various regions of the knee, if desired.", "FIGS.", "5A and 5B illustrate the type of impact that can cause the hardening of the liquid within the compartments.", "In FIG.", "5A a rotational force of sufficient magnitude will trigger a response for solidifying the liquid within the columns 12 (or columns 42 and 62).", "This rotation can be caused by an external impact or by internal impact on the brace such as by rotation or twisting of the wearer's knee.", "In FIG.", "5B a direct impact, e.g., an external impact, of sufficient force will trigger hardening of the liquid within the columns 12 (or columns 42 and 62).", "FIG.", "14 provides a flow chart to explain generally the function and use of the brace 10.Note the flow chart explains the use of the brace with liquid metal, it being understood as noted above, that other hardenable non-metal materials can be utilized.", "With reference to FIG.", "14, brace 10 is initially in a soft state.", "If an external or internal force if applied, a sensor within the brace 10, e.g., sensors 18 of FIGS.", "5A and 5B, detects such force and measures the force.", "If the force does not exceed a preset threshold or predetermined value (magnitude), then the brace remains in its softer more flexible state and no signal is sent by the sensor to activate the metal.", "However, if the measured force exceeds a preset threshold/predetermined value, a signal is sent to a controller (not shown) position in or on the brace, to activate the liquid to transform it to a hardened state.", "Activation of the liquid to transform it to a hardened state can occur in a variety of different ways as described herein.", "As shown in FIG.", "6, one way to harden the liquid is to provide a cooling mechanism to cool the liquid.", "In this embodiment, sensors 38, like sensors 18 of FIG.", "1, are positioned internally of brace 30, and located at various dispersed regions within the brace 30 to sense impact at the various regions.", "After detecting and measuring the force and determining it exceeds a predetermined or preset value, sensor 38 will send a signal to a controller (not shown).", "The controller in turn will send a signal to activate the cooling chambers 35 which surround each of the compartments 32.Such cooling of chambers 35 causes cooling of the liquid 34 in the liquid compartments 32.Upon cooling, the liquid 34 hardens, thereby forming rigid compartments and forming a protective somewhat cage-like structure.", "In the alternate embodiment of FIG.", "7, brace 50 has a single cooling chamber 53 within the brace 50.This single cooling chamber 53 functions to cool the liquid within the compartments 52 when activated in response to the force detection by the sensors 58.The cooling chamber 53 can be provided within the wall of the brace 50 or alternatively formed internal of the internal wall of the brace 50.Alternatively, more than one cooling chamber can be provided to cool the brace 50.Brace 50 therefore differs from brace 30 in that in brace 30, each liquid filled compartment 32 is partially or fully surrounded by a cooling chamber while in brace 50, cooling of the chamber positioned within the brace 50 cools the entire brace which in turn cools the liquid within the compartments.", "FIG.", "10-11B illustrates another alternate way of transforming the liquid within the compartments of the brace.", "In this embodiment, sensors 78, positioned within brace 70, detect and measure the force of impact, or rotational force, and compare it to a predetermined or preset value.", "If it exceeds such value, a signal is sent to the pump within chamber 76 to actuate the pump for pumping liquid 75 from chamber 76 through tubing 77 into the liquid filled compartment 72.A valve can be provided to seal the compartments 72 until liquid 75 is pumped therein.", "Once the pumped liquid 77 mixes with the liquid 74 in the compartments 72, a chemical reaction causes a hardening of the material within the compartments 72 and thus transforms the flexible brace 70 into a hardened cage-like structure.", "Such activation of the liquid 74 within the compartments 72 is shown schematically in FIGS.", "11A and 11B, which illustrate one of the plurality of compartments 12.If a sufficient force is detected by sensor 78, a signal is sent to activate a pump (not shown) within the chamber 76 to pump liquid 75 from chamber 76, through tubing 77, and into the chamber 72 containing liquid 74 to thereby mix liquid 75 with liquid 74.A single or multiple pumps and chambers can be provided.", "As an alternate to a pump to mix a second liquid with the liquid in the compartments, a rupturable wall or membrane could be provided.", "The brace in this embodiment would avoid the need for sensors and a controller.", "In this embodiment, brace 80 has a series of inner compartments 82, each surrounded by an outer compartment 86, and sharing a common wall.", "That is, the external wall 81 of the inner compartment 82 forms the internal wall of outer compartment 86.Wall 81 is made of a material which ruptures when a sufficient force is applied.", "In this manner, upon application of a sufficient force, the wall (membrane) 81 would break, enabling the liquid 84 of compartment 82 to mix with the liquid 85 contained in the outer compartment 86.Such mixing of the liquids causes a chemical reaction which results in a phase transformation to harden the liquid.", "In another embodiment, the liquid filled compartments are activated by an excessive bending or movement of the compartments which causes a chemical reaction as the movement (energy) provides a trigger for spontaneous transformation to a solid state.", "The liquid ferrous material in the compartments can also be activated for transformation into a solid state by electric charge, polarization or other inducement methods.", "The braces disclosed herein in some embodiments can be manually returned to the relaxed liquid state, i.e., manually overriding the transformed solid state.", "Note the control unit communicating with the sensors for controlling operation, i.e., controlling activation of the liquid through polarization, electric charge, pumping fluid, etc., can be software based and programmed to activate the liquid automatically in an as needed basis in response to signals received from the force detecting/measuring sensors.", "FIGS.", "12-13B illustrate an alternate embodiment of the brace for use in supporting a person's ankle.", "In this embodiment, ankle brace 90 is similar to the brace 10 of FIG.", "1, except it is shaped to be fitted on a user's ankle.", "That is, brace 90 has a plurality of liquid filled compartments 92.The liquid 94 can be a metal or non-metal as described above with respect to the knee braces.", "The liquid can be transformed to a harder state in any of the ways described above and thus the brace 80 can include sensors 98, similar to the sensors 18 of FIG.", "5A (or similar to sensors 38 or 88), which are spaced apart internally within the brace 90.Cooling, fluid mixing, or other methods to harden the liquid can be utilized in the ankle brace in the same way as in the knee brace to transform the ankle brace from the softer more flexible state of FIG.", "13A to the harder more rigid state of FIG.", "13B.", "The flow chart of FIG.", "14 is likewise applicable to the ankle brace 90 of FIG.", "12.The compartments 92 of brace 90 are shown extending vertically in the ankle region, but alternatively can extend diagonally, horizontally, or in other directions as in the knee brace described above.", "As shown, preferably the columns extend along or across the entire region of the brace so that the entire ankle and adjacent regions are protected.", "However, it is also contemplated that the columns can extend less than the entire length or provided only in certain regions of the brace so that only select regions of the brace are solidified.", "Additionally, the columns 92 are shown having a width 95.However, it is also contemplated that the columns can have a shorter width, thereby enabling more columns to be provided, or have thicker width, providing fewer columns.", "Further, the columns need not be of uniform width, but can have varying width.", "Such varying width can provide regions of differing hardness to accommodate various regions of the ankle and adjacent regions, if desired.", "Note for simplicity the sensors are not shown on all the Figures, it being understood that Figures illustrating views of the same embodiment would have the sensors.", "Also, the sensors illustrated are just one example of how the sensors are positioned, it being understood that a different number of sensors and different locations are also contemplated.", "While the above description contains many specifics, those specifics should not be construed as limitations on the scope of the disclosure, but merely as exemplifications of preferred embodiments thereof.", "For example, those skilled in the art will envision many other possible variations that are within the scope and spirit of the disclosure as defined by the claims appended hereto." ] ]
Patent_15875962
[ [ "TREATMENT COUCH WITH LOCALIZATION ARRAY", "Fiducial localization methods and apparatus are described." ], [ "1.An apparatus, comprising: a treatment couch; and a localization array integrated within the treatment couch.", "2.The apparatus of claim 1, wherein the treatment couch is a robotic couch.", "3.The apparatus of claim 2, wherein the treatment couch has at least five degrees of freedom of movement.", "4.The apparatus of claim 1, wherein the localization array includes at least one receiver coil and at least one transmitter coil.", "5.The apparatus of claim 1, wherein the localization array is covered.", "6.The apparatus of claim 1, wherein the localization array is centered within the treatment couch.", "7.The apparatus of claim 1, further comprising an additional localization array being either integrated within or coupled to the treatment couch.", "8.An apparatus, comprising: a treatment couch; and a localization array positioned above the treatment couch.", "9.The apparatus of claim 8, further comprising a positioning apparatus coupled with the localization array and configured to allow movement of the localization array along at least one axis parallel to a surface of the treatment couch.", "10.The apparatus of claim 8, wherein the positioning apparatus is further configured to allow positioning of the localization array beyond an imaging field of an imaging device.", "11.The apparatus of claim 8, wherein the treatment couch is a robotic couch.", "12.The apparatus of claim 8, wherein the treatment couch has at least five degrees of freedom of movement.", "13.The apparatus of claim 8, further comprising a mechanical arm coupled to the localization array configured to move the localization array independently of the treatment couch.", "14.The apparatus of claim 8, wherein the localization array includes at least one receiver coil and at least one transmitter coil.", "15.The apparatus of claim 8, further comprising an electromagnetic tracking system operatively coupled with the localization array.", "16.A method, comprising: providing a localization array in substantially an optimal position; and maintaining the localization array at substantially the optimal position by controlling movement of the localization array.", "17.The method of claim 16, wherein the localization array is integrated within a treatment couch such that the localization array is immobilized with respect to the treatment couch and controlling movement of the localization array comprises moving the treatment couch.", "18.The method of claim 16, wherein the controlling movement of the localization array comprises moving an arm coupled to the localization array.", "19.The method of claim 16, further comprising using the localization array to locate at least one fiducial marker.", "20.The method of claim 16, wherein maintaining the localization array at substantially the optimal position comprises tolerating or compensating for deviations of the localization array from the optimal position.", "21.The method of claim 16, further comprising: determining the optimal position for the localization array; and moving the localization array to substantially the optimal position.", "22.The method of claim 21, wherein determining the optimal position comprises determining a position where a detection field of the localization array encompasses at least one fiducial marker.", "23.The method of claim 21, wherein the optimal position is based on a desired characteristic of a signal received by the localization array from at least one fiducial marker.", "24.The method of claim 21, wherein the optimal position chosen to avoid obstruction by the localization array of imaging equipment or equipment relative to the localization array.", "25.The method of claim 16, wherein maintaining the localization array at substantially the optimal position is performed for at least a portion of a treatment session.", "26.The method of claim 18, further comprising moving a treatment couch independently of maintaining the localization array wherein a detection field of the localization array continues to encompass at least one fiducial marker when moving the treatment couch." ], [ "<SOH> BACKGROUND <EOH>Radiotherapy and radiosurgery are non-invasive radiation treatment options widely used to treat patients with a variety of tumors such as brain tumor, lung tumor, and liver tumor.", "Fiducial tracking is one among a variety of conventional tracking methods utilized in performing radiation treatments.", "Electromagnetic tracking systems are used to track the positions of fiducials in near real time (e.g., 10 Hz).", "In one type of system (i.e., Calypso® 4D Localization System, available from Calypso, of Seattle, Wash.), an array of four transmitter coils spread out in space induces a resonance in a fiducial or transponder coil system.", "When the magnetic field is switched off, the transponder signal during relaxation is sensed by an array of receiver coils and used to establish the position of the transponder.", "In the Calypso 4D Localization System, the transmitter and receiver coils are embedded in an array wired to a common device, and the fiducials or transponders are wireless.", "A tracking system may provide the positions of fiducials or transponders that are implanted in a patient before acquisition of a treatment planning computed tomography (CT) scan, for example for radiation therapy.", "The fiducial positions are known relative to the transmitter coils or electromagnetic localization array.", "If the transmitter coil or array position is known in the treatment room, the fiducial positions relative to the treatment room isocenter (treatment room coordinate system origin) can be obtained.", "The fiducial positions can then be used to guide treatment, for example, by directing a radiation beam at a target tracked by reference to the fiducial positions.", "In such a tracking system, inappropriate placement of the localization array may cause problems such as susceptibility to interference in the array or physical obstruction of other elements of the treatment system.", "Another problem with electromagnetic tracking systems is that the accuracy of the position and orientation information is affected by changes in the magnetic field other than those created by the transmitter coils.", "Perturbations in the magnetic field can be caused by the presence of metal (for example, in radiation therapy, a gantry or robotic manipulator and a linear accelerator) or other conductive material (for example, a treatment table top made out of conductive material).", "Thus the position information reported by an electromagnetic tracking system in practical use, for example, tracking a target region inside a patient during radiation therapy, can have a higher error than a system specification determined in a carefully controlled laboratory setting." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>The present invention is illustrated by way of example, and not by way of limitation, in the figures of the accompanying drawings.", "FIG.", "1 illustrates a treatment delivery system including localization array for tracking implanted fiducials according to one embodiment of the invention.", "FIG.", "2 illustrates a localization array integrated within a treatment couch according to one embodiment of the invention.", "FIG.", "3A illustrates a localization array mounted underneath a treatment couch using a motorized attachment mechanism according to one embodiment of the invention.", "FIG.", "3B illustrates a localization array mounted underneath a treatment couch using a motorized attachment mechanism according to one embodiment of the invention where the localization array is positioned beyond an imaging field of an imaging device.", "FIG.", "3C illustrates a localization array mounted underneath a treatment couch using a motorized attachment mechanism according to one embodiment of the invention where the localization array is rotated beyond an imaging field of an imaging device.", "FIG.", "4 illustrates a localization array attached to a treatment couch by an attachment mechanism according to one embodiment of the invention.", "FIG.", "5 is a flow chart illustrating a process for using a localization array and treatment couch assembly according to one embodiment of the invention.", "FIG.", "6 illustrates one embodiment of a treatment delivery system with an electromagnetic tracking system capable of compensating for positional information error.", "FIG.", "7 illustrates one embodiment of a localization array with embedded fiducial markers.", "FIG.", "8 illustrates one embodiment of a treatment delivery system with an electromagnetic tracking system capable of compensating for positional information error.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "REFERENCE TO RELATED APPLICATIONS This application is a divisional of U.S. patent application Ser.", "No.", "12/214,771, which claims the benefit of U.S.", "Provisional Patent Application No.", "60/936,388, which are hereby incorporated by reference.", "TECHNICAL FIELD Embodiments of the present invention relate to the field of radiation treatment, and in particular, to the positioning of an electromagnetic localization array for use in image guided radiation treatment utilizing wireless transponders.", "BACKGROUND Radiotherapy and radiosurgery are non-invasive radiation treatment options widely used to treat patients with a variety of tumors such as brain tumor, lung tumor, and liver tumor.", "Fiducial tracking is one among a variety of conventional tracking methods utilized in performing radiation treatments.", "Electromagnetic tracking systems are used to track the positions of fiducials in near real time (e.g., 10 Hz).", "In one type of system (i.e., Calypso® 4D Localization System, available from Calypso, of Seattle, Wash.), an array of four transmitter coils spread out in space induces a resonance in a fiducial or transponder coil system.", "When the magnetic field is switched off, the transponder signal during relaxation is sensed by an array of receiver coils and used to establish the position of the transponder.", "In the Calypso 4D Localization System, the transmitter and receiver coils are embedded in an array wired to a common device, and the fiducials or transponders are wireless.", "A tracking system may provide the positions of fiducials or transponders that are implanted in a patient before acquisition of a treatment planning computed tomography (CT) scan, for example for radiation therapy.", "The fiducial positions are known relative to the transmitter coils or electromagnetic localization array.", "If the transmitter coil or array position is known in the treatment room, the fiducial positions relative to the treatment room isocenter (treatment room coordinate system origin) can be obtained.", "The fiducial positions can then be used to guide treatment, for example, by directing a radiation beam at a target tracked by reference to the fiducial positions.", "In such a tracking system, inappropriate placement of the localization array may cause problems such as susceptibility to interference in the array or physical obstruction of other elements of the treatment system.", "Another problem with electromagnetic tracking systems is that the accuracy of the position and orientation information is affected by changes in the magnetic field other than those created by the transmitter coils.", "Perturbations in the magnetic field can be caused by the presence of metal (for example, in radiation therapy, a gantry or robotic manipulator and a linear accelerator) or other conductive material (for example, a treatment table top made out of conductive material).", "Thus the position information reported by an electromagnetic tracking system in practical use, for example, tracking a target region inside a patient during radiation therapy, can have a higher error than a system specification determined in a carefully controlled laboratory setting.", "BRIEF DESCRIPTION OF THE DRAWINGS The present invention is illustrated by way of example, and not by way of limitation, in the figures of the accompanying drawings.", "FIG.", "1 illustrates a treatment delivery system including localization array for tracking implanted fiducials according to one embodiment of the invention.", "FIG.", "2 illustrates a localization array integrated within a treatment couch according to one embodiment of the invention.", "FIG.", "3A illustrates a localization array mounted underneath a treatment couch using a motorized attachment mechanism according to one embodiment of the invention.", "FIG.", "3B illustrates a localization array mounted underneath a treatment couch using a motorized attachment mechanism according to one embodiment of the invention where the localization array is positioned beyond an imaging field of an imaging device.", "FIG.", "3C illustrates a localization array mounted underneath a treatment couch using a motorized attachment mechanism according to one embodiment of the invention where the localization array is rotated beyond an imaging field of an imaging device.", "FIG.", "4 illustrates a localization array attached to a treatment couch by an attachment mechanism according to one embodiment of the invention.", "FIG.", "5 is a flow chart illustrating a process for using a localization array and treatment couch assembly according to one embodiment of the invention.", "FIG.", "6 illustrates one embodiment of a treatment delivery system with an electromagnetic tracking system capable of compensating for positional information error.", "FIG.", "7 illustrates one embodiment of a localization array with embedded fiducial markers.", "FIG.", "8 illustrates one embodiment of a treatment delivery system with an electromagnetic tracking system capable of compensating for positional information error.", "DETAILED DESCRIPTION Described herein is a method and apparatus for positioning a localization array for use in image guided radiation treatment utilizing wireless transponders.", "The following description sets forth numerous specific details such as examples of specific systems, components, methods, and so forth, in order to provide a good understanding of several embodiments of the present invention.", "It will be apparent to one skilled in the art, however, that at least some embodiments of the present invention may be practiced without these specific details.", "In other instances, well-known components or methods are not described in detail or are presented in simple block diagram format in order to avoid unnecessarily obscuring the present invention.", "Thus, the specific details set forth are merely exemplary.", "Particular implementations may vary from these exemplary details and still be contemplated to be within the spirit and scope of the present invention.", "According to one embodiment of the present invention, a localization array to be used for tracking fiducial markers may be coupled with a treatment couch.", "For example, the localization array may be contained within or attached underneath or above the treatment couch.", "Such an arrangement may ensure that the localization array maintains its position with respect to the treatment couch, even if the treatment couch moves.", "Thus, the position of the localization array in the treatment room can be tracked with reference to the treatment couch, rather than tracked independently.", "Attachment of the localization array to the treatment couch may also eliminate the need for additional equipment or structures for supporting the array.", "The presence of such equipment or structures in the treatment room may block imaging equipment, such as an x-ray imager, or may physically obstruct moving equipment, such as a robotic arm for positioning a linear accelerator (LINAC).", "Accordingly, attachment of the localization array to the treatment couch may also reduce the likelihood of collisions between these pieces of equipment.", "Many approaches may be used to couple a localization array to a treatment couch at a desired position.", "For example, in one embodiment, the localization array may be contained within the treatment couch.", "In other embodiments, the localization array may be mounted underneath or above the treatment couch.", "Alternatively, the localization array may also be laid on top of the treatment couch.", "In this case, a patient undergoing radiation treatment may then lie on top of the localization array.", "A pad or other covering may be used to separate the patient and the localization array.", "The localization array may further be coupled to the treatment couch using an attachment mechanism that allows the localization array to be repositioned while remaining attached to the treatment couch.", "In other embodiments, the attachment mechanism may also allow the localization array to be detached from the treatment couch entirely and then reattached to the treatment couch at a different location.", "FIG.", "1 illustrates a radiation treatment delivery system including a localization array for tracking fiducial markers implanted in a patient's body, according to one embodiment of the invention.", "Treatment delivery system 100 includes robotic arm 101, linear accelerator (LINAC) 102, treatment couch 104 for supporting patient 103, localization array 105 for detection position of implanted fiducial markers 106, and processing unit 107.Robotic arm 101 carries a LINAC 102 that is capable of producing a beam suitable for use in radiation treatment.", "Robotic arm 101 is capable of maintaining the direction of the beam of LINAC 102 at a desired target, for example, a tumor within the body of patient 103.Robotic arm 101 may also respond to signals from a target tracking system, such as processing unit 107, to compensate for movement of the target during the treatment process.", "Treatment couch 104 may be used to support the body of patient 103 during the treatment process and may be a robotic treatment couch.", "For example, the treatment couch 104 may be a robotic couch capable of movement with at least five degrees of freedom.", "Alternatively, the treatment couch may be a robotic couch capable of movement with less than five degrees of freedom (e.g., four, three, or fewer degrees of freedom).", "In an embodiment where the treatment couch can be repositioned using a robotic arm, the position of the treatment couch in the treatment room can be determined using mechanical encoders such as sensors attached to the robot arm.", "The sensors may determine the position of the treatment couch and the localization array attached to the couch based on the joint orientations of the robotic arm.", "The treatment couch 104 may also respond to signals from a target tracking system to help compensate for movement of the target.", "Alternatively, treatment couch 104 may be another type of treatment couch, such as the Axum® treatment couch developed by Accuray, Inc. of California.", "Alternatively, other types of treatment tables may be used.", "According to one embodiment of the invention, a localization array 105 may be attached to the treatment couch 104.For example, localization array 105 may be attached to the underside of treatment couch 104 so that the detection field, a volume within which fiducial tracking is most effective, of localization array 105 is directed upwards through the treatment couch 104 and the body of patient 103.The localization array 105 may be placed so that its detection field encompasses implanted fiducial markers 106, which are implanted within the body of patient 103.The localization array can then be used to track the movement of implanted fiducial markers 106, and may include transmitter coils, receiver coils, or both transmitter and receiver coils for this purpose.", "Alternatively, transmitter coils may be removed from localization array 105, so long as the signal from the transmitter coils can still reach the implanted fiducial markers 106.Processing unit 107 may be used to collect tracking data from localization array 105 and direct robotic arm 101 to reposition the beam of LINAC 102 according to the most recently determined target position.", "The position of the target may, for example, be determined in reference to the implanted fiducials 106 if the target has a known location with respect to the implanted fiducials 106.FIG.", "2 illustrates a treatment couch assembly including an integrated localization array according to one embodiment of the invention.", "Treatment couch assembly 200 includes localization array 201, which is contained within treatment couch 202.Localization array 201 contains electromagnetic coils 203 which may be used for tracking of fiducial markers located within detection field 204.Electromagnetic coils 203 may include transmitter coils, receiver coils, or a combination of transmitter and receiver coils.", "In FIG.", "2, localization array 201 is exposed for clarity, although in some embodiments, localization array 201 may be concealed beneath the surface of treatment couch 202.Alternatively, localization array 201 may also be laid on top of treatment couch 202 and may or may not be secured to treatment couch 202.Whether laid on top or integrated within treatment couch 202, localization array 201 may be covered.", "For example, localization array 201 may be covered to protect from physical damage or for aesthetic reasons.", "The covering material may be chosen to have minimal effect on the fiducial tracking capability of the localization array 201.The covering material may also be chosen for the comfort of a patient 103 or to protect the patient 103 or the localization array 201.For example, the covering may be a pad placed over the localization array 201.Localization array 201 may also be centered with respect to treatment couch 202 along one or more axes of treatment couch 202.For example, localization array 201 may be centered along the width of treatment couch 202.Localization array 201 may, in one embodiment, cover or underlie only a portion of the surface of treatment couch 202.Alternatively, localization array 201 may cover or underlie the entire surface of treatment couch 202.While in one embodiment, treatment couch 202 contains only one localization array 201, other embodiments of treatment couch 202 may contain more than one localization array 201.During a treatment session, a patient 103 may lie on treatment couch 202 so that implanted fiducial markers 106 implanted in the body of patient 103 are within the detection field 204 of localization array 201.Localization array 201 may then be used to track the locations of implanted fiducials 106.FIG.", "3A illustrates a treatment couch assembly that includes a localization array mounted underneath the surface of a treatment couch according to one embodiment of the invention.", "Treatment couch assembly 300 includes a localization array 301 mounted underneath a treatment couch 302.Localization array 301 may be attached to a positioning mechanism 303 through an extension arm 304.Positioning mechanism 303 may be mounted on a platform 305 attached to treatment couch 302.Localization array 301 may be positioned underneath the surface of treatment couch 302 so that the detection field of localization array 301 extends through and above the surface of treatment couch 302.Localization array 301 may include transmitter coils, receiver coils, or both transmitter and receiver coils.", "Localization array 301 may also be attached to a positioning mechanism 303.In one embodiment, positioning mechanism 303 may be mounted on platform 305.Alternatively, positioning mechanism 303 may be mounted on the underside of treatment couch 302.Platform 305 may be rigidly attached to treatment couch 302 so that positioning mechanism 303 does not move with respect to treatment couch 302.Thus, repositioning of localization array 301 may occur solely through the operation of positioning mechanism 303.In alternative embodiments, positioning mechanism 303 may be attached to treatment couch 302 in a manner that allows movement between treatment couch 302 and positioning mechanism 303 and localization array 301.For example, treatment couch 302 may be mounted on slides that allow treatment couch 302 to move along the x-axis 310 with respect to positioning mechanism 303 and localization array 301.Positioning mechanism 303 may operate to move localization array 301 with respect to the treatment couch 302.For example, positioning mechanism 303 may move localization array 301 along the x-axis 310 or y-axis 311.Thus, during a radiation treatment session, the localization array 301 may be moved to a desired position so that its detection field may encompass fiducial markers being tracked without moving the patient or the treatment couch 302.Positioning mechanism 303 may also operate to move localization array 301 outside the imaging field of other imaging devices in the treatment room.", "For example, if an x-ray imager is in use, the localization array 301 may be moved out of the imaging field of the x-ray imager so that the localization array 301 is not captured in the x-ray image.", "Localization array 301 may also be moved for other reasons, such as to avoid obstructing moving equipment or personnel.", "Positioning mechanism 303 may also operate to move localization array 301 in the direction indicated by z-axis 312 in order to bring localization array 301 closer to or farther away from treatment couch 302.Positioning mechanism 303 may in one embodiment be implemented using an X-Y table.", "Alternatively, other mechanisms such as robots or non-motorized manual positioning mechanisms may be used.", "Positioning mechanism 303 may also accept inputs from a computer or other device in order to automate the movement of localization array 301 during a treatment session.", "Furthermore, positioning mechanism 303 may also send signals to another device to indicate the position of localization array 301.In one embodiment, mechanical encoders are used to determine the position of the localization array in the treatment room.", "For example, positioning mechanism 303 may utilize servo motors capable of indicating the rotational positions of the motors, which can then be used to calculate the position of the localization array 301.Alternatively, other methods for determining the location of localization array 310 may be used in conjunction with positioning mechanism 303, such as positioning marks or optical sensors.", "Localization array 301 may be attached to positioning mechanism 303 using an extension arm 304.Extension arm 304 may be used so that localization array 301 is kept away from positioning mechanism 303.For example, in cases where the operation or structure of positioning mechanism 303 may degrade the electromagnetic signals received by localization array 301, extension arm 304 may enable localization array 301 to be sufficiently removed from positioning mechanism 303 so that the electromagnetic signals are unaffected by positioning mechanism 303.Alternatively, localization array 301 may in other embodiments be attached to positioning mechanism 303 without using extension arm 304.FIG.", "3B illustrates a treatment couch assembly where the localization array is positioned beyond an imaging field of an imaging device according to one embodiment of the invention.", "Imaging device 306 is configured to capture images from within imaging field 307.Imaging device 306 may be a device such as an x-ray imager.", "Localization array 301 may be moved using positioning mechanism 303 so that localization array 301 is positioned beyond imaging field 307.With the localization array 301 in this position, imaging device 306 may avoid capturing localization array 301 in an image.", "For example, imaging device 306 may be used to capture images of a patient's anatomy while the patient is lying on treatment couch 302.In this case, allowing localization array 301 to remain in the imaging field may obscure the anatomical features which are the desired subject of the resulting image.", "FIG.", "3C illustrates a treatment couch assembly having a localization array that is rotated beyond an imaging field of an imaging device according to one embodiment of the invention.", "A rotational movement may also be used to position localization array 301 outside the imaging field 307 of imaging device 306.For example, positioning mechanism 303 may include a swivel connection to allow positioning mechanism 303 to swing localization array 301 out of the imaging field 307.FIG.", "4 illustrates a treatment couch assembly including a localization array that is secured to the treatment couch using an attachment mechanism.", "Treatment couch assembly 400 includes treatment couch 401 having a number of attachment points such as attachment point 402, clips 403 and 404, a number of positioning marks such as positioning mark 405, localization array 406, and slides 407 and 408.Clips 403 and 404 and slides 407 and 408 constitute an attachment mechanism for securing localization array 406 to treatment couch 401.Localization array 406 has a detection field 409.Treatment couch 401 may have a number of attachment points such as attachment point 402, where clips 403 and 404 may be attached.", "Localization array 406 may then be attached to clips 403 and 404.The attachment points may be located at evenly spaced positions on both sides of treatment couch 401.Each attachment point may also have a corresponding positioning mark such as positioning mark 405.The positioning marks may also be labeled with numbers or other symbols used to identify the attachment points.", "Identifying attachment points where clips 403 and 404 are attached may further facilitate determining the location of the localization array 406 with respect to treatment couch 401.This relative location may ultimately be used to locate fiducial markers such as implanted fiducials 106 tracked by the localization array 406 with respect to the beam of LINAC 102 during a radiation treatment session.", "In one embodiment, the position of the localization array 406 with respect to the treatment couch may be determined using mechanical encoders.", "For example, the attachment points or clips 403 and 404 may have sensors to indicate to which attachment points the localization array 406 is attached.", "Alternatively, if the position of the localization array 406 relative to the treatment couch is known, the position of the couch in the treatment room can be determined using mechanical encoders.", "For example, if the couch is movable on a track, sensors on the track can be used to identify the position of the couch on the sliders.", "The position of the localization array in the treatment room then can be determined by reference to the position of the treatment couch.", "The clips 403 and 404 may be attached to the attachment points using fasteners.", "For example, hooks or screw-type fasteners may be used to attach clips 403 and 404 to the attachment points.", "Other types of fasteners may also be used.", "The fasteners may be selected based on their ability to support the weight of localization array 406 and clips 403 and 404.In one embodiment, clips 403 and 404 may be separate from localization array 406 such that clips 403 and 404 may be attached to treatment couch 401 independently from localization array 406.In other embodiments, clips 403 and 404 and localization array 406 may be a single assembly to be attached to treatment couch 401 in a single piece.", "Localization array 406 may be repositioned along the x-axis 310 with respect to the treatment couch 401 by detaching clips 403 and 404, and then reattaching clips 403 and 404 at different attachment points.", "Localization array 406 may also be repositioned along the z-axis 312 by exchanging clips 403 and 404 with a set of shorter or longer clips.", "Alternatively, clips 403 and 404 may be adjustable in length so that the same clips 403 and 404 may be used to adjust the position of localization array 406 along the z-axis 312.Localization array 406 may be equipped with slides 407 and 408 to support localization array 406 on clips 403 and 404 while allowing localization array 406 to be repositioned along the y-axis 311 relative to the treatment couch 401.Using these and other mechanisms known in the art, localization array 406 may be repositioned so that its detection field 409 is in an optimal position for tracking a set of fiducial markers.", "FIG.", "5 is a flow chart illustrating a process for setting up and using an electromagnetic localization array and treatment couch assembly according to one embodiment of the invention.", "Localization array setup process 500 begins with block 501, where an optimal position for a localization array such as localization array 105 is determined.", "In one embodiment, the optimal position for localization array 105 may be a position where the detection field of localization array 105 encompasses implanted fiducial markers 106.Alternatively, an optimal position for a localization array may be determined based on other factors or a combination of factors.", "For example, the optimal position may be determined based on a desired characteristic of a signal received by the localization array 105 from the implanted fiducials 106.The optimal position may also be chosen to avoid obstruction by the localization array 105 of imaging equipment or moving equipment such as robotic arm 101.After the optimal position for the localization array is identified in block 501, execution proceeds to block 502, where positioning marks may be used to identify an attachment location for the localization array.", "For example, in one embodiment, positioning marks such as positioning mark 405 may identify one or more attachment points such as attachment point 402 where clips 403 and 404 may be attached so that localization array 406 is positioned at the optimal position.", "In other embodiments, positioning marks may not be required to identify an attachment location because the localization array may already be attached to the treatment couch.", "For example, the localization array may be integrated into the treatment couch, such as localization array 201, or the localization array may be designed to remain attached to the treatment couch between treatment sessions.", "In these cases, localization array setup process 500 may not require block 502.Following block 502 is block 503, where the localization array may be attached to the attachment location identified in block 502.For example, clips 403 and 404 supporting localization array 406 may be attached to attachment points identified in block 502 so that the localization array 406 can be positioned at the optimal position identified in block 501.In some embodiments, localization array setup process 500 may not require block 503 because the localization array may already be attached to the treatment couch.", "From block 503, execution may proceed to block 504, where the localization array may be moved to the identified optimal position.", "At this stage, the localization array may already be attached to the treatment couch.", "Thus, moving the localization array to the optimal position identified in block 501 may entail using a positioning mechanism, such as positioning mechanism 303 or slides 407 and 408, to move the localization array along one or more axes in relation to the treatment couch.", "After the localization array has been moved to the optimal position, execution may proceed to block 505, where the localization array is maintained at the optimal position during a treatment session.", "The position of the localization array may be maintained in accord with block 505 for only a portion of the entire treatment session.", "For example, if the fiducial markers move during the treatment session, the position of the localization array may be adjusted to compensate for the movement before the end of the treatment session.", "Furthermore, the localization array needs only to be sufficiently stationary to allow tracking of fiducial markers.", "For example, processing unit 107 or another part of the tracking system may tolerate or compensate for small movements of the localization array 105.The position of the localization array may be maintained by physically immobilizing the localization array with respect to the treatment couch.", "For example, if the localization array is attached to the treatment couch through a positioning mechanism such as positioning mechanism 303, the positioning mechanism may be turned off or locked in place.", "If the localization array is equipped with slides such as slides 407 and 408, then the slides may be locked, clamped, or otherwise immobilized to prevent movement of the localization array.", "Alternatively, the localization array may maintain its position without further action.", "For example, locking or clamping of slides 407 and 408 may not be required if friction is sufficient to prevent undesired movement of localization array 406.Also, if the localization array is integrated into the treatment couch, such as localization array 201, the localization array may already be immobilized with respect to the treatment couch.", "While the localization array is being maintained in a known position, the localization array may be used to track locations of fiducial markers relative to the localization array, as provided in block 506.If the position of the localization array relative to the treatment couch and the position of the treatment couch relative to other equipment are also known, then the locations of the tracked fiducial markers relative to other equipment may be determined.", "For example, the locations of the fiducial markers may be determined relative to the location of a LINAC administering radiation treatment.", "Block 506 may also be repeated during the course of the treatment session so that the location of the fiducial markers can be periodically updated.", "Thus, maintaining the localization array in a stable position relative to the treatment couch may eliminate the need for recalculating or re-detecting the positional offset of the localization array from the treatment couch each time the locations of the fiducial markers are determined.", "Furthermore, if the localization array is attached to the treatment couch, the localization array may maintain its positional offset relative to the treatment couch even if the treatment couch is moved during the treatment session.", "Another advantage of maintaining the positional offset between the localization array and the treatment table is that the fiducial markers within the detection field of the localization array may remain within the detection field of the localization array even if the treatment couch is moved.", "For example, implanted fiducial markers 106 within patient 103 lying on treatment couch 104 may be encompassed by the detection field of localization array 105.If localization array 105 is attached to treatment couch 104, then patient 103, implanted fiducials 106, localization array 105, and the detection field of localization array 105 may all move concurrently with treatment couch 104.Thus, the detection field will continue to encompass the implanted markers 106 even if the treatment couch 104 is moved, facilitating reliable tracking of the implanted fiducials 106.By tracking the locations of fiducial markers, a treatment delivery system such as treatment delivery system 100 may then use robotic arm 101 to position LINAC 102 to deliver radiation to a target that can be located with reference to the implanted fiducials 106.FIG.", "6 illustrates one embodiment of a treatment delivery system with a localization array.", "Treatment delivery system 600 is configured to compensate for positional information error in an electromagnetic tracking system resulting from perturbations in the electromagnetic tracking system's magnetic field.", "Such distortions of the magnetic field tend to increase error in the determination of the position of implanted fiducials by the electromagnetic tracking system.", "The electromagnetic tracking system of treatment delivery system 600 may include a processing unit 107, localization array 105.In one embodiment, the bias or offset error caused by perturbations in the magnetic field may be initially compensated by calibrating or characterizing the effect of the treatment delivery system (e.g., gantry system or robot-mounted LINAC 102), which could for example be a one-time procedure involving precalibration and storage of distortion offset for one or more possible positions of a gantry or robotic arm.", "In some embodiments, electromagnetic disturbances caused by equipment can be minimized by constructing the equipment from low conductivity or non-conductive materials.", "For example, the treatment couch 104 may be constructed from Kevlar.", "As compared to other light-weight materials, such as carbon-fiber, Kevlar is less conductive and thus tends to cause less distortion in the electromagnetic field.", "Nevertheless, additional sources of magnetic field distortion may not be accounted for through material selection for the treatment couch.", "A possible additional source of error is metal implants inside a patient (e.g., hip prosthesis), for which changing the material of the treatment couch or precalibrating the system may not be feasible.", "In another embodiment, an independent fiducial localization method is used in order to compute the distortion offset.", "The positions of the implanted fiducial may obtained through use of an imaging system (e.g., X-ray, x-ray computed tomography, etc.)", "that can localize the implanted fiducials with very high accuracy (e.g., several tenths of a millimeter or better).", "The difference between the imaging acquired implanted fiducial positions and the fiducial positions determined using localization array 105 is, thus, the bias or offset of the electromagnetic tracking positions.", "An x-ray imager is discussed hereafter for ease of explanation purposes.", "It should be noted again that other imaging modalities and systems such as cone-beam CT (i.e., x-ray imaging system rotated about the patient to generate a cone-beam CT) and ultrasound may be used.", "One embodiment of an X-ray imaging system includes both an X-ray source and an X-ray detector panel.", "Treatment delivery system 600 includes X-ray sources 610 and X-ray detector panels 611.The X-ray sources 610 may be mounted angularly apart, for example, about 90 degrees apart, and aimed through the treatment target (e.g., tumor within the patient) toward the X-ray detector panels 611.Alternatively, a single large detector may be used that would be illuminated by each of the X-ray sources 610.In the single detector imaging system, the X-ray sources 610 may be positioned apart at an angle less than 90 degrees to keep both images on the single detector surface.", "The detector panels 611 may be placed below the treatment target (e.g., on the floor), on the treatment couch 104, or underneath the LINAC 102, and the X-ray sources 610 may be positioned above the treatment target (e.g., the ceiling of the treatment room), to minimize magnification of the images and, therefore, the required size of the detector panels 611.In an alternative embodiment, the positions of the X-ray sources 610 and the detector panels 611 may be reversed, e.g.", "the X-ray sources 610 below the treatment target and the detector panels 611 above the treatment target.", "In another embodiment, the detector panels 611 are arranged in a manner such that they move into position for imaging and are moved out of the way during positioning of the LINAC 102 or the treatment couch 104 or during delivery of the radiation beam from the LINAC 102.By using two X-ray imagers, which could be mounted approximately orthogonally, the 2D positions of the implanted fiducials 106 in the X-ray images can be back projected to obtain their 3D positions in the treatment room.", "The fiducial positions obtained using x-ray image localization can be known with very high accuracy (several tenths of a millimeter or better).", "The difference between the X-ray image-based fiducial positions and the fiducial positions determined using localization array 105 is thus the bias or offset of the electromagnetic tracking positions.", "In one embodiment, the electromagnetic bias or offset is calculated by processing unit 107, which may be connected to localization array 105 and X-ray detector panels 611.Thus, processing unit 107 may receive the locations of the implanted fiducials 106 as determined by the localization array 105 and as determined by X-ray imaging.", "Processing unit 107 may further use the calculated electromagnetic bias or offset in controlling robotic arm 101 to direct the beam of LINAC 102 at a treatment target.", "The electromagnetic bias often changes slowly with spatial location.", "Thus, for small motions, the offset can be used to correct the real-time electromagnetic tracking positions, as determined using the localization array 105.Since electromagnetic tracking with the localization array 105 does not involve radiation exposure to the patient, it may be used to track the positions of implanted fiducials 106 in near real time.", "The use of electromagnetic tracking to avoid the use of X-ray imaging is desirable because very frequent X-ray images of the patient may result in excessive radiation exposure to the patient.", "Any bias in the electromagnetic tracking positions can be corrected by taking occasional X-ray images to locate the implanted fiducials 106 with greater accuracy.", "The frequency of the X-ray images can be varied as necessary, for example, at every position of the treatment delivery system (e.g., gantry or LINAC 102).", "Alternatively, X-ray images may be captured periodically over time.", "New X-ray images could also be acquired whenever the electromagnetic tracking fiducials move beyond a certain threshold.", "Note that using an X-ray imaging system also requires that the treatment couch (e.g., in the form of a table or chair) be relatively radiolucent.", "In order to determine the fiducial positions relative to the treatment room coordinate system, the position of localization array 105 in the treatment room needs to be known.", "The location of the localization array 105 can be obtained, for example, by tracking the array with an optical tracking system.", "However, this requires a line of sight between the array and the optical system.", "Placing the localization array 105 under the patient 103 is desirable for many reasons.", "This placement reduces potential collision issues with the treatment delivery system (gantry system or robotic arm 101 with LINAC 102).", "Placing the localization array 105 under the patient 103 could be accomplished by placing the array 105 on the treatment couch 104 and placing a pad over the array 105.The localization array 105 could also be integrated into the treatment couch 104.The localization array 105 may be movable to accommodate different patient sizes and setup positions and different treatment target positions.", "For example, localization array 105 could be placed in a platform or housing such that it can be easily moved along the long axis of the table and possibly also along the short axis of the table.", "Placing the array 105 under the patient 103, whether on or integrated into the treatment couch 104, may require a non-optical method for obtaining the position of the array 105 in the treatment room.", "One non-optical method for tracking the position of array 105 is to use one or more (e.g., two) X-ray imagers.", "FIG.", "7 illustrates one embodiment of a localization array 700 that can be tracked using X-ray imaging.", "Localization array 700 includes fiducial markers 701 that are located outside of patient 103, and also includes electromagnetic coils 203.Localization array 700 is integrated in treatment couch 202 so that detection field 204 encompasses an area above treatment couch 202.With external fiducial markers 701 embedded in array 700, the position of array 700 can be tracked using a tracking device such as an X-ray imager.", "It should be noted that the term “external fiducial markers” is used herein to distinguish from the implanted fiducials that are internal to a patient.", "Accordingly, an external fiducial marker is one which is disposed outside of a patient's body.", "External fiducial markers 701 may be made from a radio-opaque material so that external fiducials 701 will appear in X-ray images.", "By using two X-ray imagers, which could be mounted approximately orthogonally, the 2D positions of the external fiducials 701 in the X-ray images can be back projected to obtain their 3D positions.", "The 3D positions are transformed to the treatment room coordinate system and, thus, the position of the localization array 700 in the treatment room coordinate system is determined.", "Such transformations are known in the art; accordingly, a detailed description is not provided herein.", "Alternatively, electromagnetic coils 203 in the array 700 could be used as fiducials to be tracked by a tracking device.", "If the tracking device is an X-ray imager, the coils may be uniquely distinguishable radiographically.", "For example, each of the electromagnetic coils 203 may have a unique shape so that the coil and its position can be uniquely identified in an X-ray image.", "The position of localization array 700 could be determined with other methods as well.", "In one embodiment, if the localization array 700 is integrated into the treatment couch 202 and is movable with respect to treatment couch 202, a position tracking device may include mechanical encoders which can be used to obtain the position of the localization array 700 relative to the treatment couch 202.Mechanical encoders may also be used to determine the position of treatment couch 202 in the treatment room.", "Treatment couch 202 could be a conventional treatment table, or could be a table top mounted on a robotic manipulator.", "Thus, the position of localization array 700 relative to the treatment room coordinate system and the positions of implanted fiducial markers 106 in patient 103 relative to localization array 700, as electromagnetically tracked by the localization array, can be used to determine the positions of implanted fiducials 106 relative to the treatment room coordinate system.", "In addition, bias or offset error in the electromagnetically tracked position of the implanted fiducials 106 caused by disturbances in the electromagnetic field can be corrected by using occasional X-ray images to more accurately locate the implanted fiducials 106.This method for determining the location of the implanted fiducials 106 may be used not only with localization arrays that are integrated with treatment couch 104, but also with localization arrays that are not coupled to the treatment couch 104.FIG.", "8 illustrates a treatment delivery system capable of tracking the location of fiducial markers using a localization array external to the treatment couch, in conjunction with X-ray imaging according to one embodiment of the invention.", "Treatment delivery system 800 includes electromagnetic tracking system 810 connected to localization array 811.Localization array 811 has a detection field 812 that extends downwards to encompass implanted fiducials 106.Treatment delivery system 800 also includes X-ray imagers comprising X-ray sources 610 and X-ray detector panels 611.Localization array 811 may be similar to localization array 700, having electromagnetic coils that can be used to determine the positions of implanted fiducials 106.Localization array 811 is not attached to treatment couch 104, and thus may be moved independently of treatment couch 104.In one embodiment, localization array 811 is mechanically supported by electromagnetic tracking system 810.For example, localization array 811 may be mounted on an adjustable arm 813 connected to electromagnetic tracking system 810, which allows localization array 811 to be situated above patient 103.Accordingly, localization array 811 may have a detection field 812 that extends downward to encompass implanted fiducials 106 so that localization array 811 can track the positions of implanted fiducials 106.Electromagnetic tracking system 810 that is attached to localization array 811 may be an external unit containing electronics, such as drive circuitry and sensors used during the operation of localization array 811.Electromagnetic tracking system 810 may receive fiducial positions from localization array 811, and may further be connected to processing unit 107 so that the fiducial positions can be transmitted to processing unit 107.At processing unit 107, the fiducial positions can be used to control the movement of robotic arm 101.Localization array 811 may also be affected by disturbances in the electromagnetic field, such that error is increased in the electromagnetically tracked positions of the implanted fiducials 106.X-ray imagers comprising X-ray sources 610 and X-ray detector panels 611 can be used to compensate for bias or offset caused by such electromagnetic disturbances.", "By using two X-ray imagers mounted approximately orthogonally, the 2D positions of the implanted fiducials 106 in the X-ray images can be back projected to obtain their 3D positions in the treatment room with high accuracy.", "The difference between the X-ray image-based fiducial positions and the fiducial positions determined using localization array 811 is thus the bias or offset of the electromagnetic tracking positions.", "This electromagnetic bias or offset may be calculated by processing unit 107, which receives the positions of implanted fiducials 106 as determined by the localization array 105 and the X-ray imaging system.", "The offset can then be used to correct the real-time electromagnetically tracked positions, as determined using the localization array 811.Any bias in the electromagnetically tracked positions can be corrected by taking occasional X-ray images to locate the implanted fiducials 106 with greater accuracy.", "The frequency of the X-ray images can be varied as necessary, for example, at every spatial position of the treatment delivery system (e.g., gantry or LINAC 102).", "New X-ray images could also be acquired whenever the electromagnetically tracked implanted fiducials 106 move beyond a certain positional threshold.", "The resulting corrected positions of implanted fiducials 106 can be used by processing unit 107 to control robotic arm 101.Using these positions, processing unit 107 may direct robotic arm to aim LINAC 102 so that the beam of LINAC 102 intersects a treatment target that can be located by reference to the implanted fiducials 106.Alternatively, treatment delivery system 100 may be a type of system other than a robotic arm-based system.", "For example, treatment delivery system 100 may be a gantry-based (isocentric) intensity modulated radiotherapy (IMRT) system.", "In a gantry based system, a radiation source (e.g., a LINAC) is mounted on the gantry in such a way that it rotates in a plane corresponding to an axial slice of the patient.", "Radiation is then delivered from several positions on the circular plane of rotation.", "In IMRT, the shape of the radiation beam is defined by a multi-leaf collimator that allows portions of the beam to be blocked, so that the remaining beam incident on the patient has a pre-defined shape.", "The resulting system generates arbitrarily shaped radiation beams that intersect each other at the isocenter to deliver a dose distribution to the target region.", "In IMRT planning, the optimization algorithm selects subsets of the main beam and determines the amount of time that the patient should be exposed to each subset, so that the prescribed dose constraints are best met.", "In one particular embodiment, the gantry-based system may have a gimbaled radiation source head assembly.", "It should be noted that the methods and apparatus described herein are not limited to use only with medical diagnostic imaging and treatment.", "In alternative embodiments, the methods and apparatus herein may be used in applications outside of the medical technology field, such as industrial imaging and non-destructive testing of materials.", "In such applications, for example, “treatment” may refer generally to the effectuation of an operation controlled by the treatment planning system, such as the application of a beam (e.g., radiation, acoustic, etc.)", "and “target” may refer to a non-anatomical object or area.", "Certain embodiments may be implemented as a computer program product that may include instructions stored on a computer-readable medium.", "These instructions may be used to program a general-purpose or special-purpose processor to perform the described operations.", "A computer-readable medium includes any mechanism for storing or transmitting information in a form (e.g., software, processing application) readable by a computer.", "The computer-readable medium may include, but is not limited to, magnetic storage medium (e.g., floppy diskette); optical storage medium (e.g., CD-ROM); magneto-optical storage medium; read-only memory (ROM); random-access memory (RAM); erasable programmable memory (e.g., EPROM and EEPROM); flash memory; or another type of medium suitable for storing electronic instructions.", "Additionally, some embodiments may be practiced in distributed computing environments where the computer-readable medium is stored on and/or executed by more than one computer system.", "In addition, the information transferred between computer systems may either be pulled or pushed across the communication medium connecting the computer systems.", "Although the operations of the method(s) herein are shown and described in a particular order, the order of the operations of each method may be altered so that certain operations may be performed in an inverse order or so that certain operation may be performed, at least in part, concurrently with other operations.", "In another embodiment, instructions or sub-operations of distinct operations may be in an intermittent and/or alternating manner.", "In the foregoing specification, the invention has been described with reference to specific exemplary embodiments thereof.", "It will, however, be evident that various modifications and changes may be made thereto without departing from the broader spirit and scope of the invention as set forth in the appended claims.", "The specification and drawings are, accordingly, to be regarded in an illustrative sense rather than a restrictive sense." ] ]
Patent_15875966
[ [ "INTERACTIVELY PREDICTING FIELDS IN A FORM", "Methods, apparatuses, and embodiments related to interactively predicting fields in a form.", "A computer system received an image of a form.", "A user moves a cursor to a first field of the form, and the computer system automatically displays a predicted location of the field, including a bounding box that represents a boundary of the field.", "The computer system further predicts the field name/label based on text in the document.", "The user clicks on the field to indicate that he wants to digitize the field.", "When needed, the user interactively modifies the size of the bounding box that represents the extent of the field, changes the name/label of the field.", "Once finalized, the user can cause the field information (e.g., the bounding box coordinate, the bounding box location, the name/label of the field, etc.)", "to be written to a database." ], [ "1-7.", "(canceled) 8.A method comprising: receiving, by a computer system, binary data that represents an image of a form; executing an image analysis algorithm, by the computer system, that reads the binary data, that identifies visual data based on the binary data, and that analyzes the visual data to determine which of the visual data represent visual line segments; creating a data structure, by the computer system, based on an identification of the visual line segments; receiving data, by the computer system, that indicates a location of a cursor on a display and that indicates a particular location of the image; predicting a location and a boundary of a field of the form, by the computer system, by: accessing a first element of the data structure, based on the particular location of the image, to identify a visual line segment to use in a determination of a predicted location of the field; and accessing a second element of the data structure, based on a location of the visual line segment, to obtain information regarding other visual line segments to use in a determination of a predicted boundary of the field; and causing the predicted boundary of the field to be displayed at a location of the image determined based on the predicted location of the field.", "9.The method of claim 8, wherein said accessing the first element includes accessing an element of the data structure that is associated with the particular location of the image, wherein said accessing the second element includes accessing the data structure to identify visual line segments that are relevant to a determination of the boundary, wherein the data that indicates the location of the cursor is data from a mouse that controls the cursor, and wherein the particular location of the image is a rectangular portion of the image that includes a plurality of pixels of the image.", "10.The method of claim 8, wherein the particular location of the image is a location of a pixel of the image.", "11.The method of claim 8, further comprising: executing an optical character recognition (OCR) algorithm on a portion of the image that is determined based on coordinates of the predicted boundary; and determining a predicted label of the field based on results of said executing of the OCR algorithm and based on a character input by a user to indicate a label of the field; and causing the predicted label to be displayed.", "12.The method of claim 11, further comprising: in response to receipt of data that indicates an intent of the user to create the field, writing data that indicate the predicted boundary and the predicted label to a database that is associated with the image.", "13.The method of claim 12, further comprising: receiving a second image of a filled out version of the form; accessing the database to determine the coordinates of the predicted boundary; executing the OCR algorithm on a portion of the second image that is determined based on the coordinates; determining a value of the field based on said executing the OCR algorithm on the portion of the second image; and writing the value to the database to associate the value with the predicted label.", "14.The method of claim 8, wherein the portion of the second image being determined based on the coordinates includes being determined based on an oversizing of the predicted boundary.", "15.The method of claim 8, wherein the cursor indicating the particular location of the image includes the cursor being located within a predetermined distance of the particular location.", "16.The method of claim 8, wherein the field is one of a plurality of fields of a table, wherein a subset of the visual line segments indicate the plurality of fields of the table, and wherein the rectangular portion of the image includes the plurality of fields of the table.", "17.The method of claim 8, further comprising: accessing the data structure to identify a plurality of visual line segments that indicate a plurality of fields of a table; predicting a location and boundary of each of the plurality of fields of the table; and displaying the boundary of said each of the plurality of fields.", "18-23.", "(canceled) 24.A user interface method for digitizing a form based on image data of the form comprising: rendering, on a display, a document including image data of a first blank form, wherein the image data is segmented into a plurality of blocks based on a coordinate system data structure; receiving user input including a position of a cursor within a first block of the image data of the plurality of blocks identifying, by a processor via image analysis, a number of line segments visually represented within the first block of the image data; determining, by the processor, a first line segment of the number of line segments within the first block having a nearby position to the position of the cursor; and generating, by the processor, an input receiving field within the image data bounded by the first line segment.", "25.The method of claim 24, further comprising: determining, by the processor, a second line segment of the number of line segments within the first block having a nearby position to the position of the cursor and intersecting the first line segment; and wherein the input receiving field within the image data is bounded by the first and second line segment.", "26.The method of claim 24, wherein said receiving is triggered by a click from the cursor.", "27.The method of claim 24, wherein said generating the input receiving field further comprises: writing coordinates that define a boundary of the input receiving field to a database that is associated with the document; and determining a label for the input receiving field by: executing an optical character recognition (OCR) on a portion of the image that is determined based on the coordinates of the rectangular box that represents the input receiving field; based on results of said executing the OCR algorithm, displaying a suggested label for the input receiving field; and based on an indication to use the suggested label, writing the suggested label to the database.", "28.The method of claim 24, further comprising: receiving text input via the input receiving field; and saving the text input to the document.", "29.The method of claim 24, further comprising: determining the extent of the input receiving field based on additional line segments that complete a polygon with the first line segment.", "30.The method of claim 24, wherein the input receiving field is a predetermined sized positioned based on the position of the cursor and the first line segment.", "31.The method of claim 24, further comprising: identifying, by a processor via image analysis, one or more text strings visually represented within the first block of the image data; identifying a closest text string to the first line segment; and wherein the input receiving field is further bounded by the closest text string.", "32.A computing system comprising: a processor; and a memory coupled to the processor and storing instructions which, when executed by the processor, cause the computing system to perform operations including: receiving, via the networking interface, a document including image data of a first form; executing a pixel value comparison on the image data to identify a plurality of line segments thereon; receiving an indication of a particular location of the image data; comparing the particular location with a set of locations of the plurality of line segments to identify a nearest line segment to the particular location; generating an input field on the document bounded at least by the nearest line segment.", "33.The system of claim 32, wherein the memory further storing instructions which, when executed by the processor, cause the computing system to further perform: identifying an intersecting line segment of the plurality of line segments, wherein the intersecting line segment intersects the nearest line segment; and wherein the input field within the image data is bounded by the intersecting line segment.", "34.The system of claim 32, wherein the particular location is based on a user input click from a cursor.", "35.The system of claim 32, wherein said generating the input field further comprises: writing coordinates that define a boundary of the input field to a database that is associated with the image data; and determining a label for the input field by: executing an optical character recognition (OCR) on a portion of the image that is determined based on the coordinates of the rectangular box that represents the input field; based on results of said executing the OCR algorithm, displaying a suggested label for the input field; and based on an indication to use the suggested label, writing the suggested label to the database.", "36.The system of claim 32, wherein the memory further storing instructions which, when executed by the processor, cause the computing system to further perform: receiving text input via the input field; and saving the text input to the document.", "37.The system of claim 32, wherein the memory further storing instructions which, when executed by the processor, cause the computing system to further perform: determining the extent of the input field based on additional line segments that complete a polygon with the nearest line segment.", "38.The system of claim 32, wherein the input field is a predetermined sized positioned based on the particular location and the nearest line segment.", "39.The system of claim 32, wherein the memory further storing instructions which, when executed by the processor, cause the computing system to further perform: identifying via image analysis, one or more text strings visually represented within the image data; identifying a nearest text string to the nearest line segment; and wherein the input field is further bounded by the nearest text string." ], [ "<SOH> BACKGROUND <EOH>Filling out paper forms is a part of life.", "A trip to a doctor's office, to the department of motor vehicles (DMV), to an office of a potential new employer, etc., often involves filling out a paper form.", "Such forms have fields for people to provide information, such as a field for a person's name, another for his address, yet another for his phone number, etc.", "An employee of the doctor, the DMV, etc.", "often electronically captures the information entered on the form by manually entering the information into a computer.", "Once electronically captured, the information can be added to a database, a spreadsheet, an electronic document, etc., where the information can be stored for future reference." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>One or more embodiments are illustrated by way of example in the figures of the accompanying drawings, in which like references indicate similar elements.", "FIGS.", "1A-D are flow diagrams illustrating an example process of determining a location of a field on a form based on an image of the form, consistent with various embodiments.", "FIG.", "2 is diagram that illustrates a mapping between an image of a form and an associated data structure, consistent with various embodiments.", "FIG.", "3 is an illustration of a blank school registration form, consistent with various embodiments.", "FIGS.", "4A and 4B are illustrations of a Department of Motor Vehicles (DMV) form, consistent with various embodiments.", "FIG.", "5 is an illustration of a blank DMV form, consistent with various embodiments.", "FIG.", "6 is an illustration of a pH Indicator data table, consistent with various embodiments.", "FIG.", "7 in an illustration of a disease data table, consistent with various embodiments.", "FIG.", "8 is a block diagram illustrating an example of a processing system in which at least some operations described herein can be implemented, consistent with various embodiments.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "14/824,493, entitled “INTERACTIVELY PREDICTING FIELDS IN A FORM,” filed Aug. 12, 2015, which is incorporated herein by reference in its entirety.", "BACKGROUND Filling out paper forms is a part of life.", "A trip to a doctor's office, to the department of motor vehicles (DMV), to an office of a potential new employer, etc., often involves filling out a paper form.", "Such forms have fields for people to provide information, such as a field for a person's name, another for his address, yet another for his phone number, etc.", "An employee of the doctor, the DMV, etc.", "often electronically captures the information entered on the form by manually entering the information into a computer.", "Once electronically captured, the information can be added to a database, a spreadsheet, an electronic document, etc., where the information can be stored for future reference.", "BRIEF DESCRIPTION OF THE DRAWINGS One or more embodiments are illustrated by way of example in the figures of the accompanying drawings, in which like references indicate similar elements.", "FIGS.", "1A-D are flow diagrams illustrating an example process of determining a location of a field on a form based on an image of the form, consistent with various embodiments.", "FIG.", "2 is diagram that illustrates a mapping between an image of a form and an associated data structure, consistent with various embodiments.", "FIG.", "3 is an illustration of a blank school registration form, consistent with various embodiments.", "FIGS.", "4A and 4B are illustrations of a Department of Motor Vehicles (DMV) form, consistent with various embodiments.", "FIG.", "5 is an illustration of a blank DMV form, consistent with various embodiments.", "FIG.", "6 is an illustration of a pH Indicator data table, consistent with various embodiments.", "FIG.", "7 in an illustration of a disease data table, consistent with various embodiments.", "FIG.", "8 is a block diagram illustrating an example of a processing system in which at least some operations described herein can be implemented, consistent with various embodiments.", "DETAILED DESCRIPTION Introduced here is technology related to automatically identifying fields and/or tables in an image of a paper form.", "The image can be obtained, for example, by scanning or photographing the form.", "A field is a space on a form for an item of information to be entered, such as by being written or typed in the field.", "In some embodiments, a field is additionally a space on a form that contains label information related to a table.", "A field can be a standalone field, a location in a table for placing data, a location in a table that contains text that identifies a row or column of a table, etc.", "Examples of fields include a name field, an address field, a driver's license number field, a social security number field, a comment field, a symptom description field, a date field, a signature field, a row one column one field in a table, a row two column five field in a table, a field of a table that contains text where the text is used as part of labels of fields in a row or column of the table, etc.", "After a person fills out a form, which entails entering data/information in the various fields, the data/information often needs be to electronically captured and stored, such as in a database, spreadsheet, electronic document, etc.", "To improve the productivity of electronically capturing form data/information, it is desirable to automatically extract and capture information from a filled out form (i.e., a “completed” form).", "In a first example process for digitizing a form, a user obtains an image of a form by scanning the form.", "The form is preferably blank, but in some embodiments can also be filled out.", "The user views the image of the form using a computer.", "The user uses a mouse to enter a first box that defines the bounds of a first field, uses the mouse to enter a second box that defines the bounds of a second field, etc.", "The “bounds” or “boundary” of a field is one way to define the “location” of the field.", "The user next provides an identify/label for each box.", "For example, the user selects the first box using the mouse, and enters “name” using a keyboard, thereby identifying/labeling the first box as the “name” field.", "The user next selects the second box and enters “phone number”, thereby defining the second box as the “phone number” field.", "The form also includes a ten by ten data table.", "The user one by one selects boxes that represent the boundary/location of each of the one hundred fields of the data table, and types in the identity/label of each of the fields.", "For example, the user selects the row one column one field box and types “R1C1” to identify the field as the row 1 column 1 field.", "Once all of the fields of the form have been located and identified, the user, using the computer, creates a digitized representation of the form, which includes the locations and identities of all of the fields.", "Once the form has been digitized, the information entered in the various fields can be automatically extracted from an image of a completed version of the form.", "In an example, a computer system obtains an image of a completed form by scanning the completed form.", "The computer matches and aligns the image with a digitized representation of the form.", "Once matched and aligned, the locations and identities of the various fields from the digitized representation of the form can be used to locate the corresponding fields on the completed form.", "For example, (X,Y) coordinates of the “name” field box, or the “R1C1” field box, can be used to locate an area on the completed form where a person's name or the row one column one table data is expected to appear.", "Optical character recognition (OCR) can be run on an area of the form that is based on the field boundary, and the person's name or the row one column one table data can be automatically extracted based on the OCR results.", "For example, the boundary of the field can be oversized by a predetermined amount, and OCR can be run on the area of the form that overlaps with the oversized boundary box to determine text that appears within the oversized boundary box.", "Further, because the digitized representation of the form includes an identity of each field, text entered in each field can be automatically stored in the proper location in a database entry.", "For example, a database entry can be created for a particular completed form.", "A person entered “John Doe” in the “name” field, and “2.0” in the “R1C1” field of this particular completed form.", "An OCR of the “name” and “R1C1” fields of this particular completed form determined that the text in these field is, respectively, “John Doe” and “2.0”.", "The computer system writes “John Doe” to the “name” field, and “2.0” to the “R1C1” field, of the database entry for this particular completed form.", "In a second example that advantageously utilizes the techniques disclosed in this application, a user similarly obtains an image of a form by scanning the form.", "The form is preferably blank, but in some embodiments can also be filled out.", "The user views the image of the form using a computer.", "The user moves a cursor to a first field of the form, and the computer system automatically displays a predicted location of the field, including a bounding box that represents the boundary of the field.", "The computer system further predicts the field name/label based on text in the document.", "The user clicks on the field to indicate that he wants to digitize the field.", "In some embodiments, the user can interactively modify the size of the bounding box that represents the extent of the field, and can change the name/label of the field.", "Once finalized, the user can cause the field information (e.g., the bounding box coordinate, the bounding box location, the name/label of the field, etc.)", "to be written to a database.", "The user now wishes to digitize a table of the form.", "The user depresses a click/select indicator of a mouse outside one corner of the table and moves the cursor to outside the opposite corner of the table, which causes a table indicator box to be drawn such that the box encloses the table.", "The computer system predicts the locations of fields of the table, as well as field names/labels for the fields.", "The user indicates that he wants to digitize the fields of the table.", "In some embodiments, the user can interactively modify the size of the bounding boxes that represent the extents of the fields of the table, and can change the name/label of the fields of the table.", "Once finalized, the user can cause the field information (e.g., the bounding box coordinates, the bounding box locations, the name/label of the fields, etc.)", "for fields of the table to be written to a database.", "References in this description to “an embodiment”, “one embodiment”, or the like, mean that the particular feature, function, structure or characteristic being described is included in at least one embodiment of the present invention.", "Occurrences of such phrases in this specification do not necessarily all refer to the same embodiment.", "On the other hand, the embodiments referred to also are not necessarily mutually exclusive.", "Further, in this description the term “cause” and variations thereof refer to either direct causation or indirect causation.", "For example, a computer system can “cause” an action by sending a message to a second computer system that commands, requests, or prompts the second computer system to perform the action.", "Any number of intermediary devices may examine and/or relay the message during this process.", "In this regard, a device can “cause” an action even though it may not be known to the device whether the action will ultimately be executed.", "Note that in this description, any references to sending or transmitting a message, signal, etc.", "to another device (recipient device) means that the message is sent with the intention that its information content ultimately be delivered to the recipient device; hence, such references do not mean that the message must be sent directly to the recipient device.", "That is, unless stated otherwise, there can be one or more intermediary entities that receive and forward the message/signal, either “as is” or in modified form, prior to its delivery to the recipient device.", "This clarification also applies to any references herein to receiving a message/signal from another device; i.e., direct point-to-point communication is not required unless stated otherwise herein.", "FIGS.", "1A-D are flow diagrams illustrating an example process of determining a location of a field of a form based on an image of the form, consistent with various embodiments.", "At block 110, a computer system receives binary data that represents an image of a form, such as form 300 of FIG.", "3.The binary data can be created in any compatible manner, such as by scanning the form, taking a photo of the form, etc.", "The binary data can be from a scanner, camera, etc.", "that is coupled to and/or integrated with the computer system, can be from a remote computer system, can be from a mobile device such as a smart phone or tablet, etc.", "The remote computer can have a scanner, camera, etc.", "that is coupled to and/or integrated with the remote computer system, and that can be used to obtain an image of a form based on a scan or photograph of the form.", "In some embodiments, the image includes meta-data that identifies visual data, such as meta-data that identifies locations of lines, fields in the form, etc.", "In other embodiments, the image includes no meta-data that identifies visual data, such as locations of lines, locations and/or extents of fields in the form, etc.", "In such embodiments, the process of FIGS.", "1A-D advantageously is able to extract visual data from the image without relying on or needing meta-data that identifies or helps to identify the visual data.", "At block 130, the computer system creates a data structure to represent the form.", "In some embodiments, the data structure is structured to enable efficient location of fields based on interactive user input.", "In one example usage scenario, a user views an image of a form during a process of digitizing the form.", "When the user moves a cursor over a possible location of a field of the form, the data structure can be structured to enable a fast and efficient prediction and display of a possible field.", "Digitizing a form can include storing data related to fields of a form, such as locations of fields, boundaries of fields, labels of fields, etc., at a data structure to facilitate automated or semi-automated extraction of data written/typed/etc.", "at the fields of a filled-out version of the form.", "In some embodiments, the data structure is organized so that adjacent portions of an image map to adjacent elements of a data structure.", "For example, data structure 230 of FIG.", "2 is organized so that adjacent “portions” of image 220 map to adjacent elements of data structure 230.Each square of image 220 represents a “portion” of image 220, and each square of data structure 230 represents an element of data structure 230.Each corner of each square of image 220, such as the square at index (0,0), or the square at index (8,8), is coincident with a grid of image 220.Grid points 225 identifies examples of three grids, also referred to as grid points.", "As can be seen at mapping 210 and mapping 215, two adjacent “portions” of image 220 (e.g., portion (0,0) and portion (1,0)) map to adjacent elements of data structure 230 (e.g., element (0,0) and element (1,0)).", "Blocks 132-138 represent a flow diagram to perform the operation of block 130.At block 132, the computer system analyzes the image of the form.", "Features of a data structure can be determined by a computer system based on the analysis of the image.", "For example, features of a data structure, such as the number of elements of the data structure, the organization of the data structure, the data associated with each element, etc.", "can be determined based on an analysis of the image.", "In some embodiments, the computer system determines a data structure based on a grid that the computer system determines based on the image of the form.", "A grid can define the “portions” of an image.", "In FIG.", "2 for example, grid points of image 220, such as grid points 225, define “portions” of image 220, where each non-overlapping square of image 220 represents one of the “portions” of image 220.The computer system can determine the size of a grid based on an analysis of the image.", "For example, a grid can be set based on the size of a pixel of the image (e.g., grid=1 pixel×1 pixel), the size of a grouping of pixels of the image (e.g., grid=3×3 pixels), a measured portion of the image (e.g., grid=0.1 mm×0.1 mm), a percentage of a size of the image (e.g., the X grid=1% of the X dimension of the image, and the Y grid=1% of the Y dimension of the image), etc.", "When the grid is a pixel, one of the “portions” of image 220 includes data of the pixel that overlaps with one of the squares of image 220.When the grid is group of 3×3 pixels, one of the “portions” of image 220 includes data of the 9 pixels that overlap with one of the squares of image 220.Etc.", "While the current discussion focuses on a regular grid whose grid points define squares, a grid can have various characteristics that are determined based on any of various other data.", "For example, a grid can define a set of non-overlapping rectangles, such as when the grid is 2 pixels by 1 pixel.", "As another example, the grid can be irregular.", "For example, the grid of FIG.", "7 can be coincident with the line intersections of FIG.", "7, where the lines and associated line intersections are irregularly spaced.", "The computer system can determine a data structure (block 134) based on results of the analysis of block 132.In some embodiments, the computer system determines the data structure to enable data of each “portion” of the image to map to a different element of the data structure, and to enable adjacent “portions” of the image map to adjacent elements of the data structure.", "Data structure 230 of FIG.", "2 is an example of such a data structure.", "The computer system can determine any of various types of data structures, such as a linked list, an array, a hash table, etc.", "Further, the data structure can be based on any of various attributes of the image, such as the color(s) of the image, the size of the image, the resolution of the image, etc.", "In some embodiments, two elements of a data structure are considered to be adjacent when the index of each of the elements differs by one unit.", "For example, in data structure 230, the index is an ordered pair.", "For data structure 230, two elements are considered adjacent when one number of the ordered pair differs by one unit, and the other number of the ordered pair is the same.", "For example, element (0,0) is adjacent to element (1,0) because one number of the ordered pair (the first number in this example) differs by one unit, and the other number of the ordered pair is the same.", "Similarly, element (0,0) is adjacent to element (0,1) because one number of the ordered pair (the second number in this example) differs by one unit, and the other number of the ordered pair is the same.", "As discussed above, the data structure can be organized so that the relative locations of the “portions” of the image are reflected in the organization of the data structure.", "When a document, such as a form, is scanned, photographed, etc., the resulting image has a certain resolution.", "For example, the resolution of the image can be 2048 pixels by 1536 pixels, for a total of 3,145,728 pixels (or 3.1 Megapixels).", "In some embodiments, the computer system determines the grid size so that the grid matches the size of a pixel.", "In such an embodiment, each pixel of the image is associated with a particular row and column of the 2048 pixel×1536 pixel image of the form.", "In this example, a pixel located at numbered pair (0,0) is located at the bottom-left of the image, and a pixel located at (2047,1535) is located at the top-right of the photo.", "As is shown in FIG.", "2, adjacent portions (0,0) and (1,0) of image 220 map to adjacent elements (0,0) and (1,0) of data structure 230.When the portion is a pixel, adjacent pixels (0,0) and (1,0) of the image map to adjacent elements (0,0) and (1,0) of the data structure.", "At block 136, the computer system identifies a line segment.", "Some algorithms for predicting fields in a form use locations of lines on the form to predict or determine a location of a field, and a boundary of the field.", "The location of the field is where the field is located on the image of the form.", "The location can be any location associated with the field, such as the location of the middle of the field, the bottom left corner of the field, the location of a line that defines a boundary of the field, such as a bottom line of a field, etc.", "The boundary of the field defines an area on the image where a user is expected to input (e.g., write, type, etc.)", "a value for the field.", "Some embodiments of the process of FIG.", "1 are interactive, in that user input is required during the process.", "In preparation for an interactive session, a computer system can pre-populate a data structure with data derived from an image to be digitized to enable a faster and more efficient interactive user experience.", "Some embodiments advantageously load data of the form in memory in preparation for an interactive session.", "Loading the data of the form in memory, such as by loading a data structure that contains data of the form, and organizing the data to efficiently support an interactive session, can enable a much faster and responsive interactive user experience.", "Some embodiments of the process of FIG.", "1 use locations of line segments of the form in predicting or determining field locations and boundaries.", "In order to facilitate an improved interactive user experience, qualifying line segments can be stored in a data structure that is organized/structured to efficiently support an interactive session.", "Returning to block 126, in some embodiments, the computer system identifies all visible line segments of a form that meet a certain criteria.", "The computer system does this by analyzing the binary data of the image of the form to identify line segments that are visible on the form.", "Identifying line segments is well known in the art, with one example of an algorithm for doing so being a Hough Line Transform, which can be found at http://docs.opencv.org/doc/tutorials/imgproc/imgtrans/hough_lines/hough_lines.html.", "A second example of a line extractor can be found at http://docs.opencv.org/master/db/d73/classcv_1_1LineSegmentDetector.html.", "As line segments are found, they can be evaluated to determine if they meet certain criteria.", "For example, lines that do not extend a pre-determined distance may be filtered out, lines that do not run sufficiently or substantially straight in the X or Y dimension may be filtered out, lines that are or are not of a certain color or color range may be filtered out, lines that are or are not of a certain style (such as a dashed line) may be filtered out, etc.", "In some embodiments, a line is deemed to run sufficiently straight when its length in the primary direction in which the line runs is at least 600% of the length that it traverses in the non-primary direction.", "For example, a line that extends 3 inches in the X dimension may be filtered out if the difference between the maximum and minimum Y coordinates of the line segment is more than 0.5 inches.", "In some embodiments, once a line segment is determined and passes all line segment filters, the line segment is mapped to a data structure element (block 138).", "As discussed above, data of a “portion” of an image that is determined based on a grid can be mapped to an element of a data structure.", "Once the line segment is determined, the computer system determines which “portions” of the image the line passes through, and maps the line to the elements that are mapped to those “portions.” For example, where the grid is a pixel and a line runs through 1000 pixels, the line can be mapped to each of the 1000 pixels.", "The data stored at each element can include, e.g., a link to a data structure element that includes the data of the line segment, information regarding the portion of the line segment that passes through the portion of the image that maps to the element, etc.", "In some embodiments, this process is repeated for all line segments of the form, such that, once completed, the data structure includes line segment information for all line segments that met the criteria and were not filtered out.", "Once the process is complete, the data structure of such embodiments includes information regarding all the line segments that meet the criteria, thereby advantageously enabling an enhanced interactive user experience.", "At block 150, the computer system predicts a location of a field of the form.", "Any computing device, such as a remote computer system, a mobile device, etc.", "can be used to perform the operation of block 150.A mobile device can be any mobile computing device, such as a laptop computer, a smart phone, a tablet, etc.", "In some embodiments, the operations of all blocks of FIG.", "1 are performed by a computer system.", "In other embodiments, the operations of blocks 110-138 are performed by a server, and the operations of blocks 150-195 are performed by a computing device, such as a laptop computer, a desktop computer, a smart phone, a tablet, etc.", "In other embodiments, various computers perform the operations of the various blocks of FIG.", "1A-D.", "Blocks 152-158 represent a flow diagram to perform the operation of block 150.At block 152, a computer system determines a location of a cursor.", "In some embodiments, when a user begins an interactive session to digitize a form, the user views an image of the form.", "The image of the form can be displayed by any of various applications that can display images, such as an image viewer, a photo viewer, a PDF viewer, a web browser, a word processor, etc.", "The process of digitizing the form includes identifying relevant fields of the form that a user may want to automatically extract from a filled out version of the form.", "The user guides a cursor over a field, in this example field 305 of FIG.", "3.When the cursor hovers over and/or stays substantially at a selected location on the image, the computer system determines the location of the cursor, such as the location of the cursor on the image.", "Based on the location of the cursor, the computer system determines a “portion” of the image (block 154).", "The “portion” of the image can be a portion of the image that is located at the location of the cursor.", "For example, when the grid of image 300 of FIG.", "3 is a pixel and the user hovers a cursor over field 305, the computer system determines the coordinate of the cursor.", "Based on the coordinate of the cursor, and based on the size of the grid (in this example, a pixel), the computer system determines that the coordinate of the cursor intersects a particular pixel of the image (i.e., the pixel being the “portion” of the image).", "In various embodiments, the portion of the image that is determined at block 154 can be a grid, multiple grids, part of the image that is within a defined distance the location of the cursor, etc.", "At block 156, the computer system determines a location of a field based on a location of nearby line segments, and at block 158 determines an extent of the field.", "In a first example, a field is encircled by line segments.", "An example of such a field is field 405 of FIG.", "4A, where a user would enter the “MAKE” of an automobile on a DMV form.", "As discussed above, the location of the field can be any location associated with the field, such as the location of the middle of the field, the bottom left corner of the field, the location of a line that defines a boundary of the field, the location of an extent of the field, etc.", "In this example, the location of the field is the location of the line segment at the bottom of the field.", "Further, the data structure of block 130 is organized so that adjacent portions of an image map to adjacent elements of a data structure to enable a fast and efficient prediction and display of a possible field.", "In other words, when a first “portion” of the image is located “below” a second “portion” of the image, the element that maps to the first portion will be “below” the element that maps to the second portion.", "For example, in FIG.", "2, the portion of image 220 at index (0,0) is “below” the portion of image 220 at index (0,1).", "Accordingly, the element of data structure 230 at index (0,0) is also “below” the element at index (0,1).", "Based on the cursor location of block 152, and the associated “portion” of the image, the computer system accesses a data structure element associated with the “portion” of the image to determine if the element is mapped to a line segment.", "In this example, when the element is mapped to a line segment, the location of the line segment is determined and the location of the field is based on the location of this nearby line segment (block 156).", "The location of the field can be based on or can be any location characteristic of the line segment, such as a coordinate of a predetermined point on the line segment (e.g., the middle, left end, right end, etc.", "of the line segment), a location of the line segment, a location of the “portion” of the image that maps to the line segment, etc.", "When the element is not mapped to a line segment, the computer system begins walking “down” elements of the data structure to find a line segment that is “below” the element.", "In this example, the index of an element of the data structure has the format index(X,Y).", "The computer system can walk “down” elements of the structure by decrementing Y.", "For example, if the starting element has an index of (1000,900), the next element when walking “down” elements of the data structure will have an index of (1000,899).", "As the computer system walks down elements of the data structure, it determines whether the next lower element maps to a line segment.", "If not, the computer system continues to the next lower element.", "Once the computer system identifies an element that maps to a line segment, the computer system in this example determines the location of the line segment and bases the location of the field on the location of this nearby line segment (block 156).", "Once the “lower” line segment is identified, the computer system determines an extent of the field (block 158).", "In this first example, the computer system walks “up” elements of the data structure until it finds a line segment “above” the lower line segment.", "The computer system then walks “left” and “right” until it finds line segments that are “left” and “right” of the starting element.", "When the four line segments form a box, the extent of the field is based on the four line segments.", "For example, the extent of the field can be defined as the box formed by the four line segments, or by taking the box formed by the four line segments and over sizing or under sizing the box to determine the extent and/or boundary of the field.", "In a second example, a field is bounded on two or three sides by line segments.", "Examples of such fields include fields 410 and 415 of FIG.", "4A.", "In such examples, the location of nearby line segments and the location of the field are determined in a manner similar to the first example (block 156).", "However, when searching in a direction where the field is not bounded by a line, no line is found.", "When the computer system is in the process of determining the extent of the field (block 158), each discovered bounding line determines an extent of the field in one dimension.", "The extent of the field in directions where no bounding line was discovered is determined based on the end points of the bounding lines.", "For fields 410 and 415, the left extent is set to be coincident to the left ends of the top and bottom bounding line segments.", "For field 415, the right extent is similarly set to be coincident to the right ends of the top and bottom bounding line segments.", "In a third example, a field is bounded on one side by a line segment.", "An example of such a field is field 305 of FIG.", "3.In such an example, the location of nearby line segments and the location of the field are determined in a manner similar to the first example (block 156).", "However, when searching in a direction where the field is not bounded by a line, no line is found in that direction.", "When determining the extent of such a field (block 156), a computer system can set the left and right ends of the field to be coincident with the left and right ends of the discovered bounding line segment.", "The top of the extent of the field can be determined in any of several ways.", "For example, the height can be determined based on the height of text that is associated with the field.", "For field 305, the top extent of the field can be set based on the text to the left of the field, “Child's Name,” which is the text associated with field 305.The height of the field can be set equal to the height of the associated text, can be set to be a multiple of the height of the associated text (e.g., 1.5 times the height of the associated text), etc.", "As another example, the height can be determined based on the average or median height of text in the document.", "For example, the height of the field can be set equal to the median or average height of text in the document, can be set to be a multiple of the median or average height of the text in the document (e.g., 1.5 times the height of the median or average text height), etc.", "In a forth example, a field includes extraneous line segments.", "An example of such a field is field 505 of FIG.", "5.Field 505 includes line segments to denote where each character should be placed.", "In such a case, a detected nearby line segment can be filtered based on certain criteria.", "The filtering can happen prior to block 156.For example, when the line segments that form the top and bottom extents of field 505 are located, the Y dimension distance between the two line segments can be determined.", "When searching for line segments in the left or right direction, any detected vertical line segments that have a length less than a predetermined portion of the distance between the top and bottom extent line segments, such as 25% or 50% of the distance, can be filtered.", "Once the extraneous line segments are filtered, field 505 is determined in a manner similar to field 415.In a fifth example, a field is bounded on one side by a line segment, and on an opposite side by one or more line segments whose lengths are different than or are offset from the boundary line segment of the first side.", "Examples of such fields include fields 310 and 315 of FIG.", "3.In such cases, where one or more line segments are found in the vertical direction (block 156) which do not match the length and/or do not line up with the bottom line segment (e.g., the upper line segment is the same length, but is shifted in the left or right directions as compared to the bottom line segment), any of various techniques can be used to determine the upper extent of the field (block 158).", "For example, the upper extent of the field can be determined in a manner similar to the third example where the extent is based on the height of text in the document.", "As another example, the upper extent of the field can be set to be coincident with the line segment(s) found in the vertical direction, or to be coincident with the lowest line segment found in the vertical direction.", "When determining whether two line segments have the same length, or are shifted, the comparison between the line segments can include an error threshold, which can be a predetermined absolute amount, can be a predetermined relative amount, etc.", "For example, the error threshold can be 0.1 inches, can be 10% of the length of the line segment, etc.", "In a sixth example, multiple fields are bounded on the top and bottom by line segments that extend the length of the multiple fields, and are not bounded on the left or right.", "An example of such a field is field 420 of FIG.", "4A, which is bounded on the top and bottom by line segments that extend past the fields for APPLICANT'S SIGNATURE, for PRINTED NAME, and for DATE.", "In such a case, a computer system can determine the left and right extent of each field based on text associated with the fields or by the ends of the top and bottom boundary line segments (block 158).", "For example, a computer system can determine that multiple text fields are associated with the top and bottom boundary line segments based on spacing between the text.", "A computer system can evaluate the space between words, and when space between some words associated with a line segment or field exceeds a predetermined threshold, the computer system can determine that the large spacing indicates a new field.", "The threshold can be an absolute amount (e.g., a spacing more than 0.25 inches in the original image or when printed), can be a relative amount (e.g., a spacing more than two times the height of the text, more than 6 times the median spacing between words, etc.", "), among other amounts.", "Line segments 425-440 of FIG.", "4B are examples of line segments that represent the left and right extents of the multiple fields of field 420.In a seventh example, a field is part of a table.", "Examples of such fields include fields 605 and 620 of table 600 of FIG.", "6, and field 705 of table 700 of FIG.", "7.In such cases, a table can be automatically or semi-automatically detected.", "When tables 600 or 700 are automatically detected, a user can place a cursor over a field of the table, such as field 605 or field 705, and a computer system can determine the location of the cursor (block 152).", "The computer system can determine a portion of the image based on the cursor location (block 154) in a manner similar to some of the above examples.", "When determining a field based on locations of nearby line segments (block 156), which can be done in a manner similar to the first example where the field is encircled by line segments, a computer system can continue to search in the upper, lower, right, and left directions and can determine, based on the location of detected line segments, that field 605 is part of table 600, or that field 705 is part of table 700.For example, when the computer system searched in the right direction, the computer system can detect a series of similarly sized line segments.", "By doing similar searches in the left, upper, and lower directions the computer system can detect other line segments of the table in a similar manner, and, based on the detected line segments, can determine a location and extent of the table.", "When tables 600 or 700 are semi-automatically or interactively detected, a computer system can receive input from a user that indicates an existence and location of the table.", "For example, when determining a location of a cursor (block 152), a computer system can also determine that a user drew a box with a mouse or other device to indicate a table.", "For table 600/700, a user can click slightly below and to the left of the bottom left corner of table 600/700 (e.g., below and to the left of field 615/715), can continue to depress the click indicator while moving the cursor to slightly above and to the right of the top right corner of table 600/700 (e.g., above and to the right of field 610/710), where he releases the click indicator, thereby indicating a first and a second corner of a rectangle that indicates an extent of a table, in this example table 600/700.The computer can analyze line segments that are within the indicated drawn bounding rectangle to determine both the location and extent of table 600/700, as well as the location and extent of each of the fields of the table, such as field 605/705 (blocks 156 and 158).", "In table 600/700, each field is encircled by line segments, and the location and boundary of field 605/705 can be determined in a manner similar to the first example where a field is encircled by line segments.", "In some embodiments, X and Y dimensions of table 600/700 are determined, and lines that run less than a predetermined amount, such as 75% of a table dimension, are filtered.", "For example, if a line runs in the X dimension less than 75% of the X dimension of the table, or if a line runs in the Y dimension less than 75% of the Y dimension of the table, the line can be filtered out.", "At block 170, a computer system predicts a label for the field.", "Blocks 172-176 represent a flow diagram for performing the operation of block 170.A computer system can select a field based on a location of a cursor on the image of the form (block 172).", "The location of the cursor at block 172 can be the same location of the cursor at block 152, or can be a different location, for example, due to the cursor moving slightly.", "The field can be the field of block 156.The computer system can run OCR on part or all of the image to determine text of the image (block 174).", "OCR can be run on the contents of a field when a user indicates a selection of the field, can be run on the entire document during creation of a data structure at block 130, or can be run at any of various other times.", "The contents of the field can be defined by the extent of the field as determined at block 158, by under sizing or over sizing the extent of the field of block 158, e.g., over sizing the extent of the field by 50% of the height of the field, or by another method.", "A label for a field can be predicted in any of various ways (block 176).", "For example, the label can be predicted based on text that is located nearby to or at the field.", "As an example, prediction of labels for fields 305 and 310 of FIG.", "3 can be based on an analysis of text/field patterns in a row of document 300 that includes the field.", "A computer system can determine that the text CHILD'S NAME is followed by field 305, which is followed by CHILD'S SOCIAL SECURITY #, which is followed by another field.", "The computer system, based on this pattern of text/field/text/field, can predict that the first text (i.e., CHILD'S NAME) is a label for the first field (i.e., field 305), and that the second text is a label for the second field.", "As another example, a prediction of the label for field 315 can be similarly based on an analysis of text/field patterns in a row of document 300.A computer system can determine that the text PARENTS ARE: is followed by a first field, which is followed by MARRIED, which is followed by a second field, which is followed by SINGLE, which is followed by a third field, which is followed by SEPARATED, which is followed by a forth field, which is followed by DIVORCED.", "In this example, with there being text to both the left and right of each field, the computer system can additionally base a prediction of a label for a field on text punctuation.", "In this case, based on the first text ending in a colon (i.e., “:”), the computer system can predict that the text that follows each field is the label for the field, and that the label for field 315 is DIVORCED.", "As yet another example, a prediction of the label for field 405 of FIG.", "4A can be based on text that is located within the bounds of the field.", "A computer system can determine that the text MAKE lies within the boundary of field 405, and can predict that MAKE is the label for field 405.The bounds/boundary of the field can be defined by the extent of the field as determined at block 158, by a sizing of the extent of the field of block 158, or by another method.", "As yet another example, a prediction of a label for field 420 of FIG.", "4A can be based on text that is located within the bounds of the multiple fields of field 420, as is represented by line segments 425-440 of FIG.", "4B.", "In this example, a label for the first of the multiple fields of field 420 is APPLICANT'S SIGNATURE, a label for the second of the multiple fields is PRINTED NAME, and a label for the third of the multiple fields is DATE.", "A label for a field in a table, such as fields 605 or 620 of table 600 of FIG.", "6, or field 705 of table 700 of FIG.", "7, can be based on text in the outermost row(s) and column(s) of the table.", "In the example of FIG.", "6, area 625, which includes the text SAMPLES, and area 635, which includes the text PH INDICATORS, are not part of table 600.The line segments that define the extents of areas 625 and 635 and do not define the extent of table 600 (i.e., the “625/635 line segments”), are not part of table 600 in this example and can be filtered in any of several ways.", "For example, when a user draws a box using a mouse or other device to indicate a table, the user can draw the box so that it does not include the entirety of areas 625 and 635.A computer system can filter the 625/635 line segments based on their not being fully contained within the drawn box.", "In another example, a user draws the box so that it includes all of areas 625 and 635.In this example, a computer system can filter the 625/635 line segments based on the Y-dimension of area 625, and the X-dimension of area 635, not matching the X and Y dimensions of fields of table 600.In other words, the computer system can analyze fields that it finds within the drawn table indication box.", "When the computer system finds a number of abutting fields that are laid out in a table configuration, it can keep those fields, and it can filter out fields that do not match the table pattern.", "In this example, the 625/635 line segments that define boundaries of area 625 will be filtered out due to the Y dimension of area 625 not matching the Y dimension of fields of table 600.Additionally, the 625/635 line segments that define boundaries of area 635 will be filtered out due to the X dimension of area 635 not matching the X dimension of fields of table 600.This filtering will leave line segments that form the boundaries of the fields that form the rows and columns of the table.", "Contents of fields that are in the outermost row(s) and column(s) can be analyzed to predict labels for the fields of table 600 (block 176).", "A computer system analyzes table 600 and determines that fields of the left most column and top most row of table 600 include text.", "The computer system can base the labels of the fields of table 600 on the text found in these fields.", "For example, a label of field 605 can be set to “PH METER” “SODIUM CARBONATE NA2CO3”, with “PH METER” being predicted as part of the label for all fields in column 630 that are below the top most row, and with “SODIUM CARBONATE NA2CO3” being predicted as part of the label for all fields of row 640 to the right of the left most column.", "As a second example, a label of field 620 can be “RED CABBAGE EXTRACT” “MILK OF MAGNESIA MG(OH)2”.", "Labels for fields of table 700 are handled in a manner similar to the fields of table 600.In the example of FIG.", "7, a label of field 705 can be set to “NEW CASES” “MALARIA”, with “NEW CASES” being predicted as part of the label for all fields in column 720 below the top-most row of table 700, and with “SODIUM CARBONATE NA2CO3” being predicted as part of the label for all fields in row 725 to the right of the left most column of table 700.At block 190, the computer system displays a boundary that represents the field.", "The boundary can be the extent determined at block 158 of FIG.", "1C, can be the extent oversized or undersized by a predetermined amount, etc.", "For example, the boundary can be determined by oversizing the extent of the field by 0.25 inches, by undersizing the extent of the field by 10% of the height of the extent, etc.", "The boundary can be displayed in response to the user placing the cursor at a location of the field, by the user hovering the cursor or keeping the cursor substantially still over the field, etc.", "At block 195 the user digitizes the form.", "Digitizing a form can include, for example, storing data related to fields of a form, such as locations of fields, boundaries of fields, labels of fields, etc., at a data structure, such as to facilitate automated or semi-automated extraction of data written/typed/etc.", "at the fields of a filled-out version of the form.", "The data structure can be the data structure of block 130, or can be another data structure.", "For example, the computer system can create a data structure element for a field, such as for field 305 of FIG.", "3.The data structure element can include members.", "For example, as part of digitizing the form, the computer system can create members of the data structure element.", "For example, the computer system can create a member that defines the boundary of the field, another member that defines the field label, another memory that stores the location of the field, etc.", "The data structure of block 195 can be stored to disk for future use, such as when filled out versions of the form are received and the filled out values of the various fields are extracted from the form and added to a database.", "FIG.", "8 is a high-level block diagram showing an example of a processing device 800 that can represent a system to run any of the methods/algorithms described above.", "A system may include two or more processing devices such as represented in FIG.", "8, which may be coupled to each other via a network or multiple networks.", "A network can be referred to as a communication network.", "In the illustrated embodiment, the processing device 800 includes one or more processors 810, memory 811, a communication device 812, and one or more input/output (I/O) devices 813, all coupled to each other through an interconnect 814.The interconnect 814 may be or include one or more conductive traces, buses, point-to-point connections, controllers, adapters and/or other conventional connection devices.", "Each processor 810 may be or include, for example, one or more general-purpose programmable microprocessors or microprocessor cores, microcontrollers, application specific integrated circuits (ASICs), programmable gate arrays, or the like, or a combination of such devices.", "The processor(s) 810 control the overall operation of the processing device 800.Memory 811 may be or include one or more physical storage devices, which may be in the form of random access memory (RAM), read-only memory (ROM) (which may be erasable and programmable), flash memory, miniature hard disk drive, or other suitable type of storage device, or a combination of such devices.", "Memory 811 may store data and instructions that configure the processor(s) 810 to execute operations in accordance with the techniques described above.", "The communication device 812 may be or include, for example, an Ethernet adapter, cable modem, Wi-Fi adapter, cellular transceiver, Bluetooth transceiver, or the like, or a combination thereof.", "Depending on the specific nature and purpose of the processing device 800, the I/O devices 813 can include devices such as a display (which may be a touch screen display), audio speaker, keyboard, mouse or other pointing device, microphone, camera, etc.", "Unless contrary to physical possibility, it is envisioned that (i) the methods/steps described above may be performed in any sequence and/or in any combination, and that (ii) the components of respective embodiments may be combined in any manner.", "The techniques introduced above can be implemented by programmable circuitry programmed/configured by software and/or firmware, or entirely by special-purpose circuitry, or by a combination of such forms.", "Such special-purpose circuitry (if any) can be in the form of, for example, one or more application-specific integrated circuits (ASICs), programmable logic devices (PLDs), field-programmable gate arrays (FPGAs), etc.", "Software or firmware to implement the techniques introduced here may be stored on a machine-readable storage medium and may be executed by one or more general-purpose or special-purpose programmable microprocessors.", "A “machine-readable medium”, as the term is used herein, includes any mechanism that can store information in a form accessible by a machine (a machine may be, for example, a computer, network device, cellular phone, personal digital assistant (PDA), manufacturing tool, any device with one or more processors, etc.).", "For example, a machine-accessible medium includes recordable/non-recordable media (e.g., read-only memory (ROM); random access memory (RAM); magnetic disk storage media; optical storage media; flash memory devices; etc.", "), etc.", "Note that any and all of the embodiments described above can be combined with each other, except to the extent that it may be stated otherwise above or to the extent that any such embodiments might be mutually exclusive in function and/or structure.", "Although the present invention has been described with reference to specific exemplary embodiments, it will be recognized that the invention is not limited to the embodiments described, but can be practiced with modification and alteration within the spirit and scope of the appended claims.", "Accordingly, the specification and drawings are to be regarded in an illustrative sense rather than a restrictive sense." ] ]
Patent_15875969
[ [ "ANTI-PD-1 ANTIBODIES AND THEIR USES", "The present disclosure provides novel anti-PD-1 antibodies, compositions including the new antibodies, nucleic acids encoding the antibodies, and methods of making and using the same." ], [ "1.-21.", "(canceled) 22.A method of treating a cancer, comprising administering to a patient in need thereof a therapeutically effective amount of an anti-PD-1 binding protein, wherein the binding protein comprises (i) a VH chain comprising three CDRs; and (ii) a VL chain comprising three CDRs, wherein: VH CDR#1 is (SEQ ID NO: 11) GYTFTHYGMN; VH CDR#2 is (SEQ ID NO: 12) WVNTYTGEPTYADDFKG; VH CDR#3 is (SEQ ID NO: 13) EGEGLGFGD; VL CDR#1 is (SEQ ID NO: 14) RSSQSIVHSHGDTYLE; VL CDR#2 is (SEQ ID NO: 15) KVSNRFS; and VL CDR#3 is (SEQ ID NO: 16) FQGSHIPVT.", "23.The method of claim 22, wherein the cancer is selected from bladder cancer, breast cancer, head and neck cancer, kidney cancer, lung cancer, lymphoma, melanoma, and stomach cancer.", "24.The method of claim 23, wherein the lung cancer is non-small cell lung cancer.", "25.The method of claim 21, in which the anti-PD-1 binding protein is administered intravenously." ], [ "<SOH> 4.BACKGROUND <EOH>Cancer therapies comprise a wide range of therapeutic approaches, including surgery, radiation, and chemotherapy.", "While the various approaches allow a broad selection of treatments to be available to the medical practitioner to treat the cancer, existing therapeutics suffer from a number of disadvantages, such as a lack of selectivity of targeting cancer cells over normal, healthy cells, and the development of resistance by the cancer to the treatment.", "Recent approaches based on targeted therapeutics, which interfere with cellular processes of cancer cells preferentially over normal cells, have led to chemotherapeutic regimens with fewer side effects as compared to non-targeted therapies such as radiation treatment.", "Cancer immunotherapy has emerged as a promising therapeutic approach to complement existing standards of care.", "See, e.g., Miller, et al.", "Cancer Cell, 27, 439-449 (2015).", "Such immunotherapy approaches include the development of antibodies used to modulate the immune system to kill cancer cells.", "For example, interaction of PD-1, a type I cell surface receptor, with either of its two ligands, PD-L1 or PD-L2, results in a dominant negative checkpoint signal that limits subsequent antigen receptor-driven cellular activation.", "The ligands for PD-1 are differentially expressed on various tissues and cell types, including antigen-presenting cells of the immune system, and are upregulated on many types of tumor cells.", "Upregulation of PD-L1 within the tumor microenvironment is a proposed mechanism of tumors to subvert protective anti-tumor immune responses by the host.", "Antibodies directed at PD-1 that block the interaction of the receptor with either of its ligands result in inhibition of negative signaling.", "In vitro inhibition of the PD-1 mediated checkpoint signal has been demonstrated to result in prolonged antigen-specific T cell activation.", "In vivo PD-1 blockade has been shown to enhance anti-tumor immune responses in both syngeneic mouse tumor models and in human clinical trials.", "Anti-tumor immune responses in patients with solid tumors have been enhanced by anti-PD-1 treatment.", "There are two approved and marketed antagonistic anti-PD-1 monoclonal antibodies: nivolumab (OPDIVO®) and pembrolizumab (KEYTRUDA®), with approvals in the US and the European Union to treat diseases such as unresectable or metastatic melanoma and metastatic non-small cell lung cancer.", "Treatment of patients with these agents has resulted in anti-tumor responses as measured by improvement in either progression free survival and/or overall survival.", "The recent failure of OPDIVO® to slow progression of advanced lung cancer in a treatment-naïve patient population in a clinical trial comparing OPDIVO® with conventional chemotherapy highlights the need for alternative approaches and additional cancer treatments to complement existing therapeutic standards of care." ], [ "<SOH> 5.SUMMARY <EOH>The present disclosure provides anti-PD-1 antibodies and binding fragments thereof that specifically bind to PD-1.The amino acid sequences of exemplary CDRs, as well as the amino acid sequence of the V H and V L regions of the heavy and light chains of exemplary anti-PD-1 antibodies are provided in the Detailed Description below.", "Antibodies provided herein interfere with the interaction of the PD-1 receptor with either of its ligands (PD-L1, SEQ ID NO:3; PD-L2, SEQ ID NO:4), resulting in inhibition of negative signaling and upregulation of the adaptive immune response.", "The anti-PD-1 antibodies may include modifications and/or mutations that alter the properties of the antibodies, such as increase half-life, increase or decrease ADCC, etc., as is known in the art.", "Nucleic acids comprising nucleotide sequences encoding the anti-PD-1 antibodies of the disclosure are provided herein, as are vectors comprising nucleic acids.", "Additionally, prokaryotic and eukaryotic host cells transformed with a vector comprising a nucleotide sequence encoding a disclosed anti-PD-1 antibody are provided herein, as well as eukaryotic (such as mammalian) host cells engineered to express the nucleotide sequences.", "Methods of producing antibodies, by culturing host cells and recovering the antibodies are also provided, and discussed further in the Detailed Description below.", "In another aspect, the present disclosure provides compositions including the anti-PD-1 antibodies described herein.", "The compositions generally comprise one or more anti-PD-1 antibody as described herein, and/or salts thereof, and one or more excipients, carriers or diluents.", "The present disclosure provides methods of treating subjects, such as human subjects, diagnosed with a solid tumor or a blood malignancy with an anti-PD-1 antibody.", "The method generally involves administering to the subject an amount of an anti-PD-1 antibody described herein effective to provide therapeutic benefit.", "The subject may be diagnosed with any one of a number of solid tumors or blood malignancies that may be newly diagnosed, relapsed, or relapsed and refractory.", "An anti-PD-1 antibody is typically administered as an intravenous infusion twice a week, once a week, once every two weeks, once every three weeks, once every four weeks, once every five weeks, once every six weeks, once every seven weeks, or once every eight weeks.", "The anti-PD-1 antibodies may be administered as single therapeutic agents (monotherapy) or adjunctive to or with other therapeutic agents typically, but not necessarily, those used for the treatment of a solid tumor or blood malignancy.", "Therapeutic agents typically will be used at their approved dose, route of administration, and frequency of administration, but may be used at lower dosages.", "The anti-PD-1 antibodies may be administered via a variety of routes or modes of administration, including but not limited to, intravenous infusion and/or injection, intratumoral injection, and subcutaneous injection.", "The amount administered will depend upon the route of administration, the dosing schedule, the type of cancer being treated, the stage of the cancer being treated, and other parameters such as the age and weight of the patient, as is well known in the art.", "Specific exemplary dosing schedules expected to provide therapeutic benefit are provided in the Detailed Description." ], [ "1.CROSS REFERENCE TO RELATED APPLICATIONS This application claims the benefit under 35 U.S.C.", "§ 119(e) of U.S.", "Provisional Application No.", "62/394,314, filed Sep. 14, 2016, the contents of which are incorporated herein in its entirety by reference thereto.", "2.SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety.", "Said ASCII copy, created on Aug. 10, 2017, is named 381493-327US_SL.txt and is 32,733 bytes in size.", "3.TECHNICAL FIELD The present application pertains to, among other things, novel anti-PD-1 antibodies, compositions including the new antibodies, nucleic acids encoding the antibodies, and methods of making and using the same.", "4.BACKGROUND Cancer therapies comprise a wide range of therapeutic approaches, including surgery, radiation, and chemotherapy.", "While the various approaches allow a broad selection of treatments to be available to the medical practitioner to treat the cancer, existing therapeutics suffer from a number of disadvantages, such as a lack of selectivity of targeting cancer cells over normal, healthy cells, and the development of resistance by the cancer to the treatment.", "Recent approaches based on targeted therapeutics, which interfere with cellular processes of cancer cells preferentially over normal cells, have led to chemotherapeutic regimens with fewer side effects as compared to non-targeted therapies such as radiation treatment.", "Cancer immunotherapy has emerged as a promising therapeutic approach to complement existing standards of care.", "See, e.g., Miller, et al.", "Cancer Cell, 27, 439-449 (2015).", "Such immunotherapy approaches include the development of antibodies used to modulate the immune system to kill cancer cells.", "For example, interaction of PD-1, a type I cell surface receptor, with either of its two ligands, PD-L1 or PD-L2, results in a dominant negative checkpoint signal that limits subsequent antigen receptor-driven cellular activation.", "The ligands for PD-1 are differentially expressed on various tissues and cell types, including antigen-presenting cells of the immune system, and are upregulated on many types of tumor cells.", "Upregulation of PD-L1 within the tumor microenvironment is a proposed mechanism of tumors to subvert protective anti-tumor immune responses by the host.", "Antibodies directed at PD-1 that block the interaction of the receptor with either of its ligands result in inhibition of negative signaling.", "In vitro inhibition of the PD-1 mediated checkpoint signal has been demonstrated to result in prolonged antigen-specific T cell activation.", "In vivo PD-1 blockade has been shown to enhance anti-tumor immune responses in both syngeneic mouse tumor models and in human clinical trials.", "Anti-tumor immune responses in patients with solid tumors have been enhanced by anti-PD-1 treatment.", "There are two approved and marketed antagonistic anti-PD-1 monoclonal antibodies: nivolumab (OPDIVO®) and pembrolizumab (KEYTRUDA®), with approvals in the US and the European Union to treat diseases such as unresectable or metastatic melanoma and metastatic non-small cell lung cancer.", "Treatment of patients with these agents has resulted in anti-tumor responses as measured by improvement in either progression free survival and/or overall survival.", "The recent failure of OPDIVO® to slow progression of advanced lung cancer in a treatment-naïve patient population in a clinical trial comparing OPDIVO® with conventional chemotherapy highlights the need for alternative approaches and additional cancer treatments to complement existing therapeutic standards of care.", "5.SUMMARY The present disclosure provides anti-PD-1 antibodies and binding fragments thereof that specifically bind to PD-1.The amino acid sequences of exemplary CDRs, as well as the amino acid sequence of the VH and VL regions of the heavy and light chains of exemplary anti-PD-1 antibodies are provided in the Detailed Description below.", "Antibodies provided herein interfere with the interaction of the PD-1 receptor with either of its ligands (PD-L1, SEQ ID NO:3; PD-L2, SEQ ID NO:4), resulting in inhibition of negative signaling and upregulation of the adaptive immune response.", "The anti-PD-1 antibodies may include modifications and/or mutations that alter the properties of the antibodies, such as increase half-life, increase or decrease ADCC, etc., as is known in the art.", "Nucleic acids comprising nucleotide sequences encoding the anti-PD-1 antibodies of the disclosure are provided herein, as are vectors comprising nucleic acids.", "Additionally, prokaryotic and eukaryotic host cells transformed with a vector comprising a nucleotide sequence encoding a disclosed anti-PD-1 antibody are provided herein, as well as eukaryotic (such as mammalian) host cells engineered to express the nucleotide sequences.", "Methods of producing antibodies, by culturing host cells and recovering the antibodies are also provided, and discussed further in the Detailed Description below.", "In another aspect, the present disclosure provides compositions including the anti-PD-1 antibodies described herein.", "The compositions generally comprise one or more anti-PD-1 antibody as described herein, and/or salts thereof, and one or more excipients, carriers or diluents.", "The present disclosure provides methods of treating subjects, such as human subjects, diagnosed with a solid tumor or a blood malignancy with an anti-PD-1 antibody.", "The method generally involves administering to the subject an amount of an anti-PD-1 antibody described herein effective to provide therapeutic benefit.", "The subject may be diagnosed with any one of a number of solid tumors or blood malignancies that may be newly diagnosed, relapsed, or relapsed and refractory.", "An anti-PD-1 antibody is typically administered as an intravenous infusion twice a week, once a week, once every two weeks, once every three weeks, once every four weeks, once every five weeks, once every six weeks, once every seven weeks, or once every eight weeks.", "The anti-PD-1 antibodies may be administered as single therapeutic agents (monotherapy) or adjunctive to or with other therapeutic agents typically, but not necessarily, those used for the treatment of a solid tumor or blood malignancy.", "Therapeutic agents typically will be used at their approved dose, route of administration, and frequency of administration, but may be used at lower dosages.", "The anti-PD-1 antibodies may be administered via a variety of routes or modes of administration, including but not limited to, intravenous infusion and/or injection, intratumoral injection, and subcutaneous injection.", "The amount administered will depend upon the route of administration, the dosing schedule, the type of cancer being treated, the stage of the cancer being treated, and other parameters such as the age and weight of the patient, as is well known in the art.", "Specific exemplary dosing schedules expected to provide therapeutic benefit are provided in the Detailed Description.", "6.BRIEF DESCRIPTION OF THE FIGURES FIGS.", "1A-1B show the amino acid sequences of human PD-1 (SEQ ID NO:1), murine PD-1 (SEQ ID NO:2), human PD-L1 (SEQ ID NO:3), and human PD-L2 (SEQ ID NO:4).", "FIG.", "1A depicts the sequences of human and murine PD-1; FIG.", "1B depicts the sequences of human PD-L1 and PD-L2.FIG.", "2 provides amino acid sequences of VH and VL regions in exemplary anti-PD-1 antibodies of the disclosure.", "FIGS.", "3A-3C show the effects of oxidative and variable temperature conditions on exemplary humanized antibody Hu12A11.2b1 and its point mutations at Kabat 99 in CDR-H3.FIG.", "3A depicts binding to PD-1 in Jurkat cells of Hu12A11.2b1 stored at −80, 5, 25, or 40° C. for 30 days or after being subjected to oxidative conditions (1% hydrogen peroxide, “1% HP”; or 1% tert-butyl hydroperoxide, “1% TBHP”); FIG.", "3B depicts binding of anti-PD-1 antibodies Hu12A11.2b1, Hu12A11.2b2, Hu12A11.2b3, and Hu12A11.2b4; FIG.", "3C depicts the binding of Hu12A11.2b4 to PD-1 in Jurkat cells after incubation at −80, 5, 25, or 40° C. for 30 days.", "FIGS.", "4A-4B show the biological activity of nivolumab and Hu12A11.2b4 in mixed leukocyte response (MLR) and tetanus toxoid antigen recall assays.", "FIG.", "4A shows enhancement in IL-2 or interferon-gamma (IFN-γ) levels after treatment with 10 μg/mL of nivolumab, Hu12A11.2b4, or isotype control in mixed leukocyte cultures.", "FIG.", "4B shows dose-dependent response of nivolumab, Hu12A11.2b4, or isotype control on IFN-γ enhancement in tetanus toxoid response assay.", "7.DETAILED DESCRIPTION The present disclosure concerns antibodies and fragments that specifically bind PD-1, compositions comprising the antibodies, polynucleotides encoding anti-PD-1 antibodies, host cells capable of producing the antibodies, methods and compositions useful for making the antibodies and binding fragments, and various methods of using the same.", "As will be appreciated by skilled artisans, antibodies are “modular” in nature.", "Throughout the disclosure, various specific embodiments of the various “modules” composing the antibodies are described.", "As specific non-limiting examples, various specific embodiments of VH CDRs, VH chains, VL CDRs and VL chains are described.", "It is intended that all of the specific embodiments may be combined with each other as though each specific combination were explicitly described individually.", "7.1.Abbreviations The antibodies, binding fragments, and polynucleotides described herein are, in many embodiments, described by way of their respective polypeptide or polynucleotide sequences.", "Unless indicated otherwise, polypeptide sequences are provided in N→C orientation; polynucleotide sequences in 5′→3′ orientation.", "For polypeptide sequences, the conventional three or one-letter abbreviations for the genetically encoded amino acids may be used, as noted in TABLE 1, below.", "TABLE 1 Encoded Amino Acid Abbreviations Amino Acid Three Letter Abbreviation One-Letter Abbreviation Alanine Ala A Arginine Arg R Asparagine Asn N Aspartic acid Asp D Cysteine Cys C Glutamic acid Glu E Glutamine Gln Q Glycine Gly G Histidine His H Isoleucine Ile I Leucine Leu L Lysine Lys K Methionine Met M Phenylalanine Phe F Proline Pro P Serine Ser S Threonine Thr T Tryptophan Trp W Tyrosine Tyr Y Valine Val V Certain sequences are defined by structural formulae specifying amino acid residues belonging to certain classes (e.g., aliphatic, hydrophobic, etc.).", "The various classes to which the genetically encoded amino acids belong as used herein are noted in TABLE 2, below.", "Some amino acids may belong to more than one class.", "Cysteine, which contains a sulfhydryl group, and proline, which is conformationally constrained, are not assigned classes.", "TABLE 2 Encoded Amino Acid Classes Class Amino Acids Aliphatic A, I, L, V Aromatic F, Y, W Non-Polar M, A, I, L, V Polar N, Q, S, T Basic H, K, R Acidic D, E Small A, G The abbreviations used for the various exemplary antibodies disclosed herein are provided in TABLE 3, below: TABLE 3 Antibody Abbreviations Clone/Name Abbreviation VH Sequence (FIG.", "2) VL Sequence (FIG.", "2) Mouse 12A11 Mu12A11 Mu12A11 VH SEQ ID NO: 31 Mu12A11 VL SEQ ID NO: 41 Humanized 12A11.1b Hu12A11.1b Hu12A11.1b VH SEQ ID NO: 32 Hu12A11.1a VL SEQ ID NO: 42 Humanized 12A11.2b Hu12A11.2b1 Hu12A11.2b VH SEQ ID NO: 33 Hu12A11.1a VL SEQ ID NO: 42 with mouse CDRs Humanized 12A11.2b Hu12A11.2b2 Hu12A11.2b VH SEQ ID NO: 34 Hu12A11.1a VL SEQ ID NO: 42 with M99I in CDR-H3 M99I variant Humanized 12A11.2b Hu12A11.2b3 Hu12A11.2b VH SEQ ID NO: 35 Hu12A11.1a VL SEQ ID NO: 42 with M99V in CDR-H3 M99V variant Humanized 12A11.2b Hu12A11.2b4 Hu12A11.2b VH SEQ ID NO: 36 Hu12A11.1a VL SEQ ID NO: 42 with M99L in CDR-H3 M99L variant 7.2.Definitions Unless otherwise defined herein, scientific and technical terms used in connection with the present disclosure shall have the meanings that are commonly understood by those of ordinary skill in the art.", "7.3.Anti-PD-1 Antibodies and Binding Fragments In one aspect, the disclosure concerns antibodies and/or binding fragments thereof that specifically bind programmed cell death protein 1 (PD-1) receptor (also known as PDCD1, CD279, PD1, SLEB2, or SLE1).", "As used herein, the term “antibody” (Ab) refers to an immunoglobulin molecule that specifically binds to a particular antigen—here, PD-1.In some embodiments, the anti-PD-1 antibodies of the disclosure bind to human PD-1 and thereby modulate the immune system.", "The resulting immune system response is cytotoxic to tumor cells.", "Anti-PD-1 antibodies of the disclosure comprise complementarity determining regions (CDRs), also known as hypervariable regions, in both the light chain and the heavy chain variable domains.", "The more highly conserved portions of variable domains are called the framework (FR).", "As is known in the art, the amino acid position/boundary delineating a hypervariable region of an antibody can vary, depending on the context and the various definitions known in the art.", "Some positions within a variable domain may be viewed as hybrid hypervariable positions in that these positions can be deemed to be within a hypervariable region under one set of criteria while being deemed to be outside a hypervariable region under a different set of criteria.", "One or more of these positions can also be found in extended hypervariable regions.", "The disclosure provides antibodies comprising modifications in these hybrid hypervariable positions.", "The variable domains of native heavy and light chains each comprise four FR regions, largely by adopting a β-sheet configuration, connected by three CDRs, which form loops connecting, and in some cases forming part of, the β-sheet structure.", "The CDRs in each chain are held together in close proximity by the FR regions and, with the CDRs from the other chain, contribute to the formation of the target binding site of antibodies.", "See Kabat et al., Sequences of Proteins of Immunological Interest (National Institute of Health, Bethesda, Md.", "1987).", "As used herein, numbering of immunoglobulin amino acid residues is done according to the immunoglobulin amino acid residue numbering system of Kabat et al.", "unless otherwise indicated.", "The antibodies of the disclosure may be polyclonal, monoclonal, genetically engineered, and/or otherwise modified in nature, including but not limited to chimeric antibodies, humanized antibodies, human antibodies, single chain antibodies, etc.", "In various embodiments, the antibodies comprise all or a portion of a constant region of an antibody.", "In some embodiments, the constant region is an isotype selected from: IgA (e.g., IgA1 or IgA2), IgD, IgE, IgG (e.g., IgG1, IgG2, IgG3 or IgG4), and IgM.", "In specific embodiments, the antibodies described herein comprise an IgG1.In other embodiments, the anti-PD-1 antibodies comprise an IgG2.In yet other embodiments, the anti-PD-1 antibodies comprise an IgG4.As used herein, the “constant region” of an antibody includes the natural constant region, allotypes or natural variants, such as D356E and L358M, or A431G in human IgG1.See, e.g., Jefferis and Lefranc, MAbs, 1(4): 332-338 (July-August 2009).", "The light constant region of an anti-PD-1 antibody may be a kappa (κ) light region or a lambda (λ) region.", "A λ light region can be any one of the known subtypes, e.g., λ1, λ2, λ3, or λ4.In some embodiments, the anti-PD-1 antibody comprises a kappa (κ) light region.", "The term “monoclonal antibody” as used herein is not limited to antibodies produced through hybridoma technology.", "A monoclonal antibody is derived from a single clone, including any eukaryotic, prokaryotic, or phage clone, by any means available or known in the art.", "Monoclonal antibodies useful with the present disclosure can be prepared using a wide variety of techniques known in the art including the use of hybridoma, recombinant, and phage display technologies, or a combination thereof.", "In many uses of the present disclosure, including in vivo use of the anti-PD-1 antibodies in humans, chimeric, humanized, or human antibodies can suitably be used.", "The term “chimeric” antibody as used herein refers to an antibody having variable sequences derived from a non-human immunoglobulin, such as a rat or a mouse antibody, and human immunoglobulin constant regions, typically chosen from a human immunoglobulin template.", "Methods for producing chimeric antibodies are known in the art.", "See, e.g., Morrison, 1985, Science 229(4719):1202-7; Oi et al., 1986, BioTechniques 4:214-221; Gillies et al., 1985, J. Immunol.", "Methods 125:191-202; U.S. Pat.", "Nos.", "5,807,715; 4,816,567; and 4,816,397.“Humanized” forms of non-human (e.g., murine) antibodies are chimeric immunoglobulins that contain minimal sequences derived from non-human immunoglobulin.", "In general, a humanized antibody will comprise substantially all of at least one, and typically two, variable domains, in which all or substantially all of the CDR regions correspond to those of a non-human immunoglobulin and all or substantially all of the FR regions are those of a human immunoglobulin sequence.", "The humanized antibody can also comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin consensus sequence.", "Methods of antibody humanization are known in the art.", "See, e.g., Riechmann et al., 1988, Nature 332:323-7; U.S. Pat.", "Nos.", "5,530,101; 5,585,089; 5,693,761; 5,693,762; and U.S. Pat.", "No.", "6,180,370 to Queen et al.", "; EP239400; PCT publication WO 91/09967; U.S. Pat.", "No.", "5,225,539; EP592106; EP519596; Padlan, 1991, Mol.", "Immunol., 28:489-498; Studnicka et al., 1994, Prot.", "Eng.", "7:805-814; Roguska et al., 1994, Proc.", "Natl.", "Acad.", "Sci.", "91:969-973; and U.S. Pat.", "No.", "5,565,332.“Human antibodies” include antibodies having the amino acid sequence of a human immunoglobulin and include antibodies isolated from human immunoglobulin libraries or from animals transgenic for one or more human immunoglobulins and that do not express endogenous immunoglobulins.", "Human antibodies can be made by a variety of methods known in the art including phage display methods using antibody libraries derived from human immunoglobulin sequences.", "See U.S. Pat.", "Nos.", "4,444,887 and 4,716,111; and PCT publications WO 98/46645; WO 98/50433; WO 98/24893; WO 98/16654; WO 96/34096; WO 96/33735; and WO 91/10741.Human antibodies can also be produced using transgenic mice which are incapable of expressing functional endogenous immunoglobulins but which can express human immunoglobulin genes.", "See, e.g., PCT publications WO 98/24893; WO 92/01047; WO 96/34096; WO 96/33735; U.S. Pat.", "Nos.", "5,413,923; 5,625,126; 5,633,425; 5,569,825; 5,661,016; 5,545,806; 5,814,318; 5,885,793; 5,916,771; and 5,939,598.In addition, companies such as LakePharma, Inc. (Belmont, Calif.) or Creative BioLabs (Shirley, N.Y.) can be engaged to provide human antibodies directed against a selected antigen using technology similar to that described above.", "Fully human antibodies that recognize a selected epitope can be generated using a technique referred to as “guided selection.” In this approach, a selected non-human monoclonal antibody, e.g., a mouse antibody, is used to guide the selection of a completely human antibody recognizing the same epitope (see, Jespers et al., 1988, Biotechnology 12:899-903).", "Anti-PD-1 antibodies of the disclosure include full-length (intact) antibody molecules.", "In some embodiments, the present disclosure also includes anti-PD-1 binding fragments that are capable of specifically binding PD-1.Examples of antibody binding fragments include by way of example and not limitation, Fab, Fab′, F(ab′)2, Fv fragments, single chain Fv fragments and single domain fragments.", "An Fab fragment contains the constant domain of the light chain and the first constant domain (CH1) of the heavy chain.", "Fab′ fragments differ from Fab fragments by the addition of a few residues at the carboxyl terminus of the heavy chain CH1 domain including one or more cysteines from the antibody hinge region.", "F(ab′) fragments are produced by cleavage of the disulfide bond at the hinge cysteines of the F(ab′)2 pepsin digestion product.", "Additional chemical couplings of antibody fragments are known to those of ordinary skill in the art.", "Fab and F(ab′)2 fragments lack the Fc fragment of an intact antibody, clear more rapidly from the circulation of animals, and may have less non-specific tissue binding than an intact antibody (see, e.g., Wahl et al., 1983, J. Nucl.", "Med.", "24:316).", "An “Fv” fragment is the minimum fragment of an antibody that contains a complete target recognition and binding site.", "This region consists of a dimer of one heavy and one light chain variable domain in a tight, non-covalent association (VH-VL dimer).", "It is in this configuration that the three CDRs of each variable domain interact to define a target binding site on the surface of the VH-VL dimer.", "Often, the six CDRs confer target binding specificity to the antibody.", "However, in some instances even a single variable domain (or half of an Fv comprising only three CDRs specific for a target) can have the ability to recognize and bind target, although at a lower affinity than the entire binding site.", "“Single-chain Fv” or “scFv” antibody binding fragments comprise the VH and VL domains of an antibody, where these domains are present in a single polypeptide chain.", "Generally, the Fv polypeptide further comprises a polypeptide linker between the VH and VL domains which enables the scFv to form the desired structure for target binding.", "“Single domain antibodies” are composed of a single VH or VL domains which exhibit sufficient affinity to PD-1.In a specific embodiment, the single domain antibody is a camelized antibody (See, e.g., Riechmann, 1999, Journal of Immunological Methods 231:25-38).", "The anti-PD-1 antibodies of the disclosure include derivatized antibodies.", "For example, but not by way of limitation, derivatized antibodies are typically modified by glycosylation, acetylation, pegylation, phosphorylation, amidation, derivatization by known protecting/blocking groups, proteolytic cleavage, linkage to a cellular ligand or other protein.", "Any of numerous chemical modifications can be carried out by known techniques, including, but not limited to, specific chemical cleavage, acetylation, formylation, metabolic synthesis of tunicamycin, etc.", "Additionally, the derivative can contain one or more non-natural amino acids, e.g., using ambrx technology (See, e.g., Wolfson, 2006, Chem.", "Biol.", "13(10):1011-2).", "The anti-PD-1 antibodies or binding fragments may be antibodies or fragments whose sequences have been modified to alter at least one constant region-mediated biological effector function.", "For example, in some embodiments, an anti-PD-1 antibody may be modified to reduce at least one constant region-mediated biological effector function relative to the unmodified antibody, e.g., reduced binding to one or more of the Fc receptors (FcγR) such as FcγRI, FcγRIIA, FcγRIIB, FcγRIIIA and/or FcγRIIIB.", "FcγR binding can be reduced by mutating the immunoglobulin constant region segment of the antibody at particular regions necessary for FcγR interactions (See, e.g., Canfield and Morrison, 1991, J. Exp.", "Med.", "173:1483-1491; and Lund et al., 1991, J. Immunol.", "147:2657-2662).", "Reduction in FcγR binding ability of the antibody can also reduce other effector functions which rely on FcγR interactions, such as opsonization, phagocytosis and antigen-dependent cellular cytotoxicity (“ADCC”).", "The anti-PD-1 antibody or binding fragment described herein include antibodies that have been modified to acquire or improve at least one constant region-mediated biological effector function relative to an unmodified antibody, e.g., to enhance FcγR interactions (See, e.g., US Patent Appl.", "No.", "2006/0134709).", "For example, an anti-PD-1 antibody of the disclosure can have a constant region that binds FcγRI, FcγRIIA, FcγRIIB, FcγRIIIA and/or FcγRIIIB with greater affinity than the corresponding wild type constant region.", "Thus, antibodies of the disclosure may have alterations in biological activity that result in increased or decreased opsonization, phagocytosis, or ADCC.", "Such alterations are known in the art.", "For example, modifications in antibodies that reduce ADCC activity are described in U.S. Pat.", "No.", "5,834,597.An exemplary ADCC lowering variant corresponds to “mutant 3” (also known as “M3,” shown in FIG.", "4 of U.S. Pat.", "No.", "5,834,597) in which residues 234 and 237 (using EU numbering) are substituted with alanines.", "A mutant 3 (also known as “M3”) variation may be used in a number of antibody isotypes, e.g., IgG2.Additional substitutions that can modify FcγR binding and/or ADCC effector function of an anti-PD-1 antibody include the K322A substitution or the L234A and L235A double substitution in the Fc region.", "See, e.g., Hezareh, et al.", "J.", "Virol., 75 (24): 12161-12168 (2001).", "In some embodiments, the anti-PD-1 antibodies of the disclosure have low levels of, or lack, fucose.", "Antibodies lacking fucose have been correlated with enhanced ADCC activity, especially at low doses of antibody.", "See Shields et al., 2002, J. Biol.", "Chem.", "277:26733-26740; Shinkawa et al., 2003, J. Biol.", "Chem.", "278:3466-73.Methods of preparing fucose-less antibodies include growth in rat myeloma YB2/0 cells (ATCC CRL 1662).", "YB2/0 cells express low levels of FUT8 mRNA, which encodes α-1,6-fucosyltransferase, an enzyme necessary for fucosylation of polypeptides.", "The anti-PD-1 antibodies of the disclosure can comprise modified (or variant) CH2 domains or entire Fc domains that include amino acid substitutions that increase binding to FcγRIIB and/or reduced binding to FcγRIIIA as compared to the binding of a corresponding wild-type CH2 or Fc region.", "Variant CH2 or variant Fc domains have been described in U.S. Patent Appl.", "No.", "2014/0377253.A variant CH2 or variant Fc domain typically includes one or more substitutions at position 263, position 266, position 273, and position 305, wherein the numbering of the residues in the Fc domain is that of the EU index as in Kabat.", "In some embodiments, the anti-PD-1 antibodies comprise one or more substitutions selected from V263L, V266L, V273C, V273E, V273F, V273L, V273M, V273S, V273Y, V305K, and V305W, relative to the wild-type CH2 domain.", "In specific embodiments, the one or more substitutions of the CH2 domain are selected from V263L, V273E, V273F, V273M, V273S, and V273Y, relative to the CH2 domain of a human IgG1.For example, the one or more substitutions of an IgG1 CH2 domain can be V273E.", "In another specific embodiment, the anti-PD-1 antibody of the disclosure comprises a variant IgG1 hinge region comprising the amino acid substitution V263L.", "Other examples of variant CH2 or variant Fc domains that can afford increased binding to FcγRIIB and/or reduced binding to FcγRIIIA as compared to the binding of a corresponding wild-type CH2 or Fc region include those found in Vonderheide, et al.", "Clin.", "Cancer Res., 19(5), 1035-1043 (2013), such as S267E or S267E/L328F in human IgG1.Anti-PD-1 antibodies or binding fragments that comprise a human IgG4 constant region can comprise the S228P mutation, which has been reported to prevent Fab arm exchange.", "See, e.g., Silva, J P et al.", "Journal of Biological Chemistry, 290(9), 5462-5469 (2015).", "In some embodiments, the anti-PD-1 antibodies or binding fragments include modifications that increase or decrease their binding affinities to the fetal Fc receptor, FcRn, for example, by mutating the immunoglobulin constant region segment at particular regions involved in FcRn interactions (see, e.g., WO 2005/123780).", "In particular embodiments, an anti-PD-1 antibody of the IgG class is mutated such that at least one of amino acid residues 250, 314, and 428 of the heavy chain constant region is substituted alone, or in any combinations thereof, such as at positions 250 and 428, or at positions 250 and 314, or at positions 314 and 428, or at positions 250, 314, and 428, with positions 250 and 428 a specific combination.", "For position 250, the substituting amino acid residue can be any amino acid residue other than threonine, including, but not limited to, alanine, cysteine, aspartic acid, glutamic acid, phenylalanine, glycine, histidine, isoleucine, lysine, leucine, methionine, asparagine, proline, glutamine, arginine, serine, valine, tryptophan, or tyrosine.", "For position 314, the substituting amino acid residue can be any amino acid residue other than leucine, including, but not limited to, alanine, cysteine, aspartic acid, glutamic acid, phenylalanine, glycine, histidine, isoleucine, lysine, methionine, asparagine, proline, glutamine, arginine, serine, threonine, valine, tryptophan, or tyrosine.", "For position 428, the substituting amino acid residues can be any amino acid residue other than methionine, including, but not limited to, alanine, cysteine, aspartic acid, glutamic acid, phenylalanine, glycine, histidine, isoleucine, lysine, leucine, asparagine, proline, glutamine, arginine, serine, threonine, valine, tryptophan, or tyrosine.", "An exemplary substitution known to modify Fc effector function is the Fc substitution M428L, which can occur in combination with the Fc substitution T250Q.", "Additional specific combinations of suitable amino acid substitutions are identified in Table 1 of U.S. Pat.", "No.", "7,217,797.Such mutations increase binding to FcRn, which protects the antibody from degradation and increases its half-life.", "An anti-PD-1 antibody may have one or more amino acids inserted into one or more of its CDRs, for example as described in Jung and Plückthun, 1997, Protein Engineering 10:9, 959-966; Yazaki et al., 2004, Protein Eng.", "Des Sel.", "17(5):481-9.Epub 2004 Aug. 17; and U.S. Pat.", "Appl.", "No.", "2007/0280931.Anti-PD-1 antibodies with high affinity for human PD-1 may be desirable for therapeutic and diagnostic uses.", "Accordingly, the present disclosure contemplates antibodies having a high binding affinity to human PD-1.In specific embodiments, the anti-PD-1 antibodies that bind human PD-1 with an affinity of at least about 100 nM, but may exhibit higher affinity, for example, at least about 90 nM, 80 nM, 70 nM, 60 nM, 50 nM, 40 nM, 30 nM, 25 nM, 20 nM, 15 nM, 10 nM, 7 nM, 6 nM, 5 nM, 4 nM, 3 nM, 2 nM, 1 nM, 0.1 nM, 0.01 nM, or even higher.", "In some embodiments, the antibodies bind human PD-1 with an affinity in the range of about 1 pM to about 100 nM, or an affinity ranging between any of the foregoing values.", "Affinity of anti-PD-1 antibodies for human PD-1 can be determined using techniques well known in the art or described herein, such as for example, but not by way of limitation, ELISA, isothermal titration calorimetry (ITC), surface plasmon resonance, or fluorescent polarization assay.", "Anti-PD-1 antibodies generally comprise a heavy chain comprising a variable region (VH) having three complementarity determining regions (“CDRs”) referred to herein (in N→C order) as VH CDR#1, VH CDR#2, and VH CDR#3, and a light chain comprising a variable region (VL) having three complementarity determining regions referred to herein (in N→C order) as VL CDR#1, VL CDR#2, and VL CDR#3.The amino acid sequences of exemplary CDRs, as well as the amino acid sequence of the VH and VL regions of the heavy and light chains of exemplary anti-PD-1 are provided herein.", "Specific embodiments of anti-PD-1 antibodies include these exemplary CDRs and/or VH and/or VL sequences, as well as antibodies that compete for binding human PD-1 with such antibodies.", "In some embodiments, an anti-PD-1 antibody is suitable for administration to humans.", "In a specific embodiment, the anti-PD-1 antibody is humanized.", "In some embodiments, the amino acid sequences of the CDRs of an anti-PD-1 antibody are selected from the following sequences: CDR Sequence (N→C) Identifier VH CDR#1: GYTFTHYGMN (SEQ ID NO: 11) VH CDR#2: WVNTYTGEPTYADDFKG (SEQ ID NO: 12) VH CDR#3: EGEGLGFGD (SEQ ID NO: 13) EGEGIGFGD (SEQ ID NO: 21) EGEGVGFGD (SEQ ID NO: 22) EGEGMGFGD (SEQ ID NO: 23) VL CDR#1: RSSQSIVHSHGDTYLE (SEQ ID NO: 14) VL CDR#2: KVSNRFS (SEQ ID NO: 15) VL CDR#3: FQGSHIPVT (SEQ ID NO: 16) Specific exemplary embodiments of anti-PD-1 antibodies with the above CDRs are described herein.", "In some embodiments, an anti-PD-1 antibody has the CDRs of SEQ ID NOS: 11, 12, 13, 14, 15, and 16.In some embodiments, an anti-PD-1 antibody has the CDRs of SEQ ID NOS: 11, 12, 21, 14, 15, and 16.In some embodiments, an anti-PD-1 antibody has the CDRs of SEQ ID NOS: 11, 12, 22, 14, 15, and 16.In some embodiments, an anti-PD-1 antibody has the CDRs of SEQ ID NOS: 11, 12, 23, 14, 15, and 16.In some embodiments, each CDR of an anti-PD-1 antibody, independently of the others, is selected to correspond in sequence to the respective CDR of an antibody provided in TABLE 3.In some embodiments, an anti-PD-1 antibody is an IgG, and has a VH and VL corresponding in sequence to the VH and VL of an antibody provided in TABLE 3.In some embodiments, an anti-PD-1 antibody comprises a VH chain corresponding in sequence to SEQ ID NO:31; and a VL chain corresponding in sequence to SEQ ID NO:41.In some embodiments, an anti-PD-1 antibody comprises a VH chain corresponding in sequence to SEQ ID NO:32; and a VL chain corresponding in sequence to SEQ ID NO:42.In some embodiments, an anti-PD-1 antibody comprises a VH chain corresponding in sequence to SEQ ID NO:33; and a VL chain corresponding in sequence to SEQ ID NO:42.In some embodiments, an anti-PD-1 antibody comprises a VH chain corresponding in sequence to SEQ ID NO:34; and a VL chain corresponding in sequence to SEQ ID NO:42.In some embodiments, an anti-PD-1 antibody comprises a VH chain corresponding in sequence to SEQ ID NO:35; and a VL chain corresponding in sequence to SEQ ID NO:42.In some embodiments, an anti-PD-1 antibody comprises a VH chain corresponding in sequence to SEQ ID NO:36; and a VL chain corresponding in sequence to SEQ ID NO:42.Certain mutations of a VH or VL sequence in an anti-PD-1 antibody described herein would be understood by a person of skill to afford anti-PD-1 antibodies within the scope of the disclosure.", "Mutations may include amino acid substitutions, additions, or deletions from a VH or VL sequence as disclosed herein while retaining significant anti-PD-1 activity.", "Accordingly, in some embodiments, an anti-PD-1 antibody comprises a VH sequence having at least 85%, at least 90%, at least 93%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the VH sequence of any one of the antibodies shown in TABLE 3.An anti-PD-1 antibody can comprise a VH sequence having up to 8, up to 7, up to 6, up to 5, up to 4, up to 3, or up to 2 mutations compared with the VH sequence of any one of the antibodies shown in TABLE 3.In some embodiments, an anti-PD-1 antibody can comprise a VH sequence having 5 or fewer, 4 or fewer, 3 or fewer, or 2 or fewer mutations compared with the VH sequence of any one of the antibodies shown in TABLE 3.In some embodiments, an anti-PD-1 antibody comprises a VL sequence having at least 85%, at least 90%, at least 93%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the VL sequence of any one of the antibodies shown in TABLE 3.An anti-PD-1 antibody can comprise a VL sequence having up to 8, up to 7, up to 6, up to 5, up to 4, up to 3, or up to 2 mutations compared with the VL sequence of any one of the antibodies shown in TABLE 3.In some embodiments, an anti-PD-1 antibody can comprise a VL sequence having 5 or fewer, 4 or fewer, 3 or fewer, or 2 or fewer mutations compared with the VL sequence of any one of the antibodies shown in TABLE 3.In some embodiments, an anti-PD-1 antibody comprises a heavy chain amino acid sequence according to: (SEQ ID NO: 51) EIQLVQSGAEVKKPGSSVKVSCKASGYTFTHYGMNWVRQAPGQGLEWVGW VNTYTGEPTYADDFKGRLTFTLDTSTSTAYMELSSLRSEDTAVYYCTREG EGLGFGDWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDY FPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYI CNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKD TLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNST YRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVY TLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLD SDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK; and a light chain amino acid sequence according to: (SEQ ID NO: 61) DVVMTQSPLSLPVTPGEPASISCRSSQSIVHSHGDTYLEWYLQKPGQSPQ LLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHIP VTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAK VQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACE VTHQGLSSPVTKSFNRGEC, wherein the underlined amino acids represent the CDRs and the italicized amino acids represent the constant regions.", "Post-translational modifications to the sequences of an anti-PD-1 antibody may occur, such as cleavage of one or more (e.g., 1, 2, 3, or more) amino acid residues on the C-terminal end of the antibody heavy chain.", "In some embodiments, an anti-PD-1 antibody comprises a heavy chain amino acid sequence according to: (SEQ ID NO: 52) EIQLVQSGAEVKKPGSSVKVSCKASGYTFTHYGMNWVRQAPGQGLEWVGW VNTYTGEPTYADDFKGRLTFTLDTSTSTAYMELSSLRSEDTAVYYCTREGE GLGFGDWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFP EPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNV NHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMI SRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVS VLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSR EENITKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFF LYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG; and a light chain amino acid sequence according to: (SEQ ID NO: 61) DVVMTQSPLSLPVTPGEPASISCRSSQSIVHSHGDTYLEWYLQKPGQSPQ LLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHIP VTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAK VQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACE VTHQGLSSPVTKSFNRGEC, wherein the underlined amino acids represent the CDRs and the italicized amino acids represent the constant regions.", "Additional post-translational modifications of an anti-PD-1 antibody may include glycosylation.", "Common biantennary complexes can be composed of a core structure having two N-acetylglucosamine (GlcNAc), three mannose, and two GlcNAc residues that are β-1,2 linked to α-6 mannose and α-3 mannose to form two antennae.", "One or more fucose (Fuc), galactose (Gal), high mannose glycans Man-5 or Man-9, bisecting GlcNAc, and sialic acid including N-acetylneuraminic acid (NANA) or N-glycolylneuraminic acid (NGNA) residues may be attached to the core.", "N-linked glycoforms may include G0 (protein having a core biantennary glycosylation structure), G0F (fucosylated G0), G0F GlcNAc, G1 (protein having a core glycosylation structure with one galactose residue), G1F (fucosylated G1), G2 (protein having a core glycosylation structure with two galactose residues), and/or G2F (fucosylated G2).", "In some embodiments, an anti-PD-1 antibody has a G0F glycan.", "In some embodiments, the anti-PD-1 antibodies compete for binding human PD-1 in in vitro assays with a reference antibody.", "In some embodiments, the anti-PD-1 antibodies compete for binding human PD-1 on cells expressing human PD-1.The reference antibody may be any of the anti-PD-1 antibodies described herein.", "In some embodiments, the reference antibody is an antibody provided in TABLE 3.In specific embodiments, the reference antibody is selected from mouse antibody 12A11 (“Mu12A11”).", "In some embodiments, the reference antibody is a humanized version of Mu12A11.In a specific embodiment, the reference antibody is humanized antibody 12A11.1b (“Hu12A11.1b”) or humanized antibody 12A11.2b M99L (“Hu12A11.2b4”).", "In some embodiments, the anti-PD-1 antibodies antagonize, e.g., inhibit, human PD-1 (SEQ ID NO:1).", "PD-1 receptor antagonism can occur by a number of mechanisms, for example, by inhibiting binding of PD-1 by human PD-L1 (SEQ ID NO:3) or PD-L2 (SEQ ID NO:4).", "The anti-PD-1 antibodies described herein generally bind specifically to human PD-1.Cross reactivity of the antibodies for binding to PD-1 from other species, for example, from monkey, e.g., cynomolgus monkey, may offer advantages, such as the ability to test in monkey animal models for biological activity.", "Such animal model testing may be used to screen anti-PD-1 antibodies to select properties related to efficacy, e.g., favorable pharmacokinetics, or those related to safety, e.g., decreased hepatic toxicity.", "In some embodiments, the anti-PD-1 antibodies bind to cynomolgus PD-1 as well as human PD-1.Assays for competition include, but are not limited to, a radioactive material labeled immunoassay (RIA), an enzyme-linked immunosorbent assay (ELISA), a sandwich ELISA, fluorescence activated cell sorting (FACS) assays, and surface plasmon resonance assays.", "In conducting an antibody competition assay between a reference antibody and a test antibody (irrespective of species or isotype), one may first label the reference with a detectable label, such as a fluorophore, biotin or an enzymatic (or even radioactive) label to enable subsequent identification.", "In this case, cells expressing human PD-1 are incubated with unlabeled test antibody, labeled reference antibody is added, and the intensity of the bound label is measured.", "If the test antibody competes with the labeled reference antibody by binding to an overlapping epitope, the intensity will be decreased relative to a control reaction carried out without test antibody.", "In a specific embodiment of this assay, the concentration of labeled reference antibody that yields 80% of maximal binding (“conc80%”) under the assay conditions (e.g., a specified density of cells) is first determined, and a competition assay carried out with 10× conc80% of unlabeled test antibody and conc80% of labeled reference antibody.", "The inhibition can be expressed as an inhibition constant, or Ki, which is calculated according to the following formula: Ki=IC50/(1+[reference Ab concentration]/Kd), where IC50 is the concentration of test antibody that yields a 50% reduction in binding of the reference antibody and Kd is the dissociation constant of the reference antibody, a measure of its affinity for human PD-1.Antibodies that compete with anti-PD-1 antibodies disclosed herein can have a Ki from 10 pM to 10 nM under assay conditions described herein.", "In various embodiments, a test antibody is considered to compete with a reference antibody if it decreases binding of the reference antibody by at least about 20% or more, for example, by at least about 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95% or even more, or by a percentage ranging between any of the foregoing values, at a reference antibody concentration that is 80% of maximal binding under the specific assay conditions used, and a test antibody concentration that is 10-fold higher than the reference antibody concentration.", "A specific assay and assay conditions useful for assessing whether an antibody competes for binding human PD-1 with a reference antibody as described herein is provided in Section 8.1.5.7.4.Polynucleotides Encoding the Anti-PD-1 Antibodies, Expression Systems and Methods of Making the Antibodies The present disclosure encompasses nucleic acid molecules encoding immunoglobulin light and heavy chain genes for anti-PD-1 antibodies, vectors comprising such nucleic acids, and host cells capable of producing the anti-PD-1 antibodies of the disclosure.", "An anti-PD-1 antibody of the disclosure can be prepared by recombinant expression of immunoglobulin light and heavy chain genes in a host cell.", "To express an antibody recombinantly, a host cell is transfected with one or more recombinant expression vectors carrying DNA fragments encoding the immunoglobulin light and heavy chains of the antibody such that the light and heavy chains are expressed in the host cell and, optionally, secreted into the medium in which the host cells are cultured, from which medium the antibodies can be recovered.", "Standard recombinant DNA methodologies are used to obtain antibody heavy and light chain genes, incorporate these genes into recombinant expression vectors and introduce the vectors into host cells, such as those described in Molecular Cloning; A Laboratory Manual, Second Edition (Sambrook, Fritsch and Maniatis (eds), Cold Spring Harbor, N. Y., 1989), Current Protocols in Molecular Biology (Ausubel, F. M. et al., eds., Greene Publishing Associates, 1989) and in U.S. Pat.", "No.", "4,816,397.To generate nucleic acids encoding such anti-PD-1 antibodies, DNA fragments encoding the light and heavy chain variable regions are first obtained.", "These DNAs can be obtained by amplification and modification of germline DNA or cDNA encoding light and heavy chain variable sequences, for example using the polymerase chain reaction (PCR).", "Germline DNA sequences for human heavy and light chain variable region genes are known in the art (See, e.g., the “VBASE” human germline sequence database; see also Kabat, E. A. et al., 1991, Sequences of Proteins of Immunological Interest, Fifth Edition, U.S. Department of Health and Human Services, NIH Publication No.", "91-3242; Tomlinson et al., 1992, J. Mol.", "Biol.", "22T:116-198; and Cox et al., 1994, Eur.", "J. Immunol.", "24:827-836; the contents of each of which are incorporated herein by reference).", "Once DNA fragments encoding anti-PD-1 antibody-related VH and VL segments are obtained, these DNA fragments can be further manipulated by standard recombinant DNA techniques, for example to convert the variable region genes to full-length antibody chain genes, to Fab fragment genes or to a scFv gene.", "In these manipulations, a VL- or VH-encoding DNA fragment is operatively linked to another DNA fragment encoding another protein, such as an antibody constant region or a flexible linker.", "The term “operatively linked,” as used in this context, is intended to mean that the two DNA fragments are joined such that the amino acid sequences encoded by the two DNA fragments remain in-frame.", "The isolated DNA encoding the VH region can be converted to a full-length heavy chain gene by operatively linking the VH-encoding DNA to another DNA molecule encoding heavy chain constant regions (CH1, CH2, CH3 and, optionally, CH4).", "The sequences of human heavy chain constant region genes are known in the art (See, e.g., Kabat, E. A., et al., 1991, Sequences of Proteins of Immunological Interest, Fifth Edition, U.S. Department of Health and Human Services, NIH Publication No.", "91-3242) and DNA fragments encompassing these regions can be obtained by standard PCR amplification.", "The heavy chain constant region can be an IgG1, IgG2, IgG3, IgG4, IgA, IgE, IgM or IgD constant region, but in certain embodiments is an IgG1 or IgG4.For a Fab fragment heavy chain gene, the VH-encoding DNA can be operatively linked to another DNA molecule encoding only the heavy chain CH1 constant region.", "The isolated DNA encoding the VL region can be converted to a full-length light chain gene (as well as a Fab light chain gene) by operatively linking the VL-encoding DNA to another DNA molecule encoding the light chain constant region, CL.", "The sequences of human light chain constant region genes are known in the art (See, e.g., Kabat, et al., 1991, Sequences of Proteins of Immunological Interest, Fifth Edition, U.S. Department of Health and Human Services, NIH Publication No.", "91-3242) and DNA fragments encompassing these regions can be obtained by standard PCR amplification.", "The light chain constant region can be a kappa or lambda constant region, but in certain embodiments is a kappa constant region.", "To create a scFv gene, the VH- and VL-encoding DNA fragments are operatively linked to another fragment encoding a flexible linker, e.g., encoding the amino acid sequence (Gly4˜Ser)3 (SEQ ID NO:5), such that the VH and VL sequences can be expressed as a contiguous single-chain protein, with the VL and VH regions joined by the flexible linker (See, e.g., Bird et al., 1988, Science 242:423-426; Huston et al., 1988, Proc.", "Natl.", "Acad.", "Sci.", "USA 85:5879-5883; McCafferty et al., 1990, Nature 348:552-554).", "To express the anti-PD-1 antibodies of the disclosure, DNAs encoding partial or full-length light and heavy chains, obtained as described above, are inserted into expression vectors such that the genes are operatively linked to transcriptional and translational control sequences.", "In this context, the term “operatively linked” is intended to mean that an antibody gene is ligated into a vector such that transcriptional and translational control sequences within the vector serve their intended function of regulating the transcription and translation of the antibody gene.", "The expression vector and expression control sequences are chosen to be compatible with the expression host cell used.", "The antibody light chain gene and the antibody heavy chain gene can be inserted into separate vectors or, more typically, both genes are inserted into the same expression vector.", "The antibody genes are inserted into the expression vector by standard methods (e.g., ligation of complementary restriction sites on the antibody gene fragment and vector, or blunt end ligation if no restriction sites are present).", "Prior to insertion of the anti-PD-1 antibody-related light or heavy chain sequences, the expression vector can already carry antibody constant region sequences.", "For example, one approach to converting the anti-PD-1 monoclonal antibody-related VH and VL sequences to full-length antibody genes is to insert them into expression vectors already encoding heavy chain constant and light chain constant regions, respectively, such that the VH segment is operatively linked to the CH segment(s) within the vector and the VL segment is operatively linked to the CL segment within the vector.", "Additionally or alternatively, the recombinant expression vector can encode a signal peptide that facilitates secretion of the antibody chain from a host cell.", "The antibody chain gene can be cloned into the vector such that the signal peptide is linked in-frame to the amino terminus of the antibody chain gene.", "The signal peptide can be an immunoglobulin signal peptide or a heterologous signal peptide (i.e., a signal peptide from a non-immunoglobulin protein).", "In addition to the antibody chain genes, the recombinant expression vectors of the disclosure carry regulatory sequences that control the expression of the antibody chain genes in a host cell.", "The term “regulatory sequence” is intended to include promoters, enhancers and other expression control elements (e.g., polyadenylation signals) that control the transcription or translation of the antibody chain genes.", "Such regulatory sequences are described, for example, in Goeddel, Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif., 1990.It will be appreciated by those skilled in the art that the design of the expression vector, including the selection of regulatory sequences may depend on such factors as the choice of the host cell to be transformed, the level of expression of protein desired, etc.", "Suitable regulatory sequences for mammalian host cell expression include viral elements that direct high levels of protein expression in mammalian cells, such as promoters and/or enhancers derived from cytomegalovirus (CMV) (such as the CMV promoter/enhancer), Simian Virus 40 (SV40) (such as the SV40 promoter/enhancer), adenovirus, (e.g., the adenovirus major late promoter (AdMLP)) and polyoma.", "For further description of viral regulatory elements, and sequences thereof, see, e.g., U.S. Pat.", "No.", "5,168,062 by Stinski, U.S. Pat.", "No.", "4,510,245 by Bell et al., and U.S. Pat.", "No.", "4,968,615 by Schaffner et al.", "In addition to the antibody chain genes and regulatory sequences, the recombinant expression vectors of the disclosure can carry additional sequences, such as sequences that regulate replication of the vector in host cells (e.g., origins of replication) and selectable marker genes.", "The selectable marker gene facilitates selection of host cells into which the vector has been introduced (See, e.g., U.S. Pat.", "Nos.", "4,399,216, 4,634,665 and 5,179,017, all by Axel et al.).", "For example, typically the selectable marker gene confers resistance to drugs, such as G418, hygromycin or methotrexate, on a host cell into which the vector has been introduced.", "Suitable selectable marker genes include the dihydrofolate reductase (DHFR) gene (for use in DHFR− host cells with methotrexate selection/amplification) and the neo gene (for G418 selection).", "For expression of the light and heavy chains, the expression vector(s) encoding the heavy and light chains is transfected into a host cell by standard techniques.", "The various forms of the term “transfection” are intended to encompass a wide variety of techniques commonly used for the introduction of exogenous DNA into a prokaryotic or eukaryotic host cell, e.g., electroporation, lipofection, calcium-phosphate precipitation, DEAE-dextran transfection and the like.", "It is possible to express the antibodies of the disclosure in either prokaryotic or eukaryotic host cells.", "In certain embodiments, expression of antibodies is performed in eukaryotic cells, e.g., mammalian host cells, of optimal secretion of a properly folded and immunologically active antibody.", "Exemplary mammalian host cells for expressing the recombinant antibodies of the disclosure include Chinese Hamster Ovary (CHO cells) (including DHFR− CHO cells, described in Urlaub and Chasin, 1980, Proc.", "Natl.", "Acad.", "Sci.", "USA 77:4216-4220, used with a DHFR selectable marker, e.g., as described in Kaufman and Sharp, 1982, Mol.", "Biol.", "159:601-621), NSO myeloma cells, COS cells and SP2 cells.", "When recombinant expression vectors encoding antibody genes are introduced into mammalian host cells, the antibodies are produced by culturing the host cells for a period of time sufficient to allow for expression of the antibody in the host cells or secretion of the antibody into the culture medium in which the host cells are grown.", "Antibodies can be recovered from the culture medium using standard protein purification methods.", "Host cells can also be used to produce portions of intact antibodies, such as Fab fragments or scFv molecules.", "It is understood that variations on the above procedure are within the scope of the present disclosure.", "For example, it can be desirable to transfect a host cell with DNA encoding either the light chain or the heavy chain (but not both) of an anti-PD-1 antibody of this disclosure.", "Recombinant DNA technology can also be used to remove some or all of the DNA encoding either or both of the light and heavy chains that is not necessary for binding to human PD-1.The molecules expressed from such truncated DNA molecules are also encompassed by the antibodies of the disclosure.", "For recombinant expression of an anti-PD-1 antibody of the disclosure, the host cell can be co-transfected with two expression vectors of the disclosure, the first vector encoding a heavy chain derived polypeptide and the second vector encoding a light chain derived polypeptide.", "The two vectors can contain identical selectable markers, or they can each contain a separate selectable marker.", "Alternatively, a single vector can be used which encodes both heavy and light chain polypeptides.", "Once a nucleic acid encoding one or more portions of an anti-PD-1 antibody has been obtained, further alterations or mutations can be introduced into the coding sequence, for example to generate nucleic acids encoding antibodies with different CDR sequences, antibodies with reduced affinity to the Fc receptor, or antibodies of different subclasses.", "The anti-PD-1 antibodies of the disclosure can also be produced by chemical synthesis (e.g., by the methods described in Solid Phase Peptide Synthesis, 2nd ed., 1984 The Pierce Chemical Co., Rockford, Ill.).", "Variant antibodies can also be generated using a cell-free platform (See, e.g., Chu et al., Biochemia No.", "2, 2001 (Roche Molecular Biologicals) and Murray et al., 2013, Current Opinion in Chemical Biology, 17:420-426).", "Once an anti-PD-1 antibody of the disclosure has been produced by recombinant expression, it can be purified by any method known in the art for purification of an immunoglobulin molecule, for example, by chromatography (e.g., ion exchange, affinity, and sizing column chromatography), centrifugation, differential solubility, or by any other standard technique for the purification of proteins.", "Further, the anti-PD-1 antibodies of the present disclosure can be fused to heterologous polypeptide sequences described herein or otherwise known in the art to facilitate purification.", "Once isolated, the anti-PD-1 antibody can, if desired, be further purified, e.g., by high performance liquid chromatography (see, e.g., Fisher, Laboratory Techniques In Biochemistry And Molecular Biology, Work and Burdon, eds., Elsevier, 1980), or by gel filtration chromatography on a Superdex™ 75 column (Pharmacia Biotech AB, Uppsala, Sweden).", "7.5.Pharmaceutical Compositions The anti-PD-1 antibodies described herein may be in the form of compositions comprising the antibody and one or more carriers, excipients and/or diluents.", "The compositions may be formulated for specific uses, such as for veterinary uses or pharmaceutical uses in humans.", "The form of the composition (e.g., dry powder, liquid formulation, etc.)", "and the excipients, diluents and/or carriers used will depend upon the intended uses of the antibody and, for therapeutic uses, the mode of administration.", "For therapeutic uses, the compositions may be supplied as part of a sterile, pharmaceutical composition that includes a pharmaceutically acceptable carrier.", "This composition can be in any suitable form (depending upon the desired method of administering it to a patient).", "The pharmaceutical composition can be administered to a patient by a variety of routes such as orally, transdermally, subcutaneously, intranasally, intravenously, intramuscularly, intratumorally, intrathecally, topically or locally.", "The most suitable route for administration in any given case will depend on the particular antibody, the subject, and the nature and severity of the disease and the physical condition of the subject.", "Typically, the pharmaceutical composition will be administered intravenously or subcutaneously.", "Pharmaceutical compositions can be conveniently presented in unit dosage forms containing a predetermined amount of an anti-PD-1 antibody described herein per dose.", "The quantity of anti-PD-1 antibody included in a unit dose will depend on the disease being treated, as well as other factors as are well known in the art.", "Such unit dosages may be in the form of a lyophilized dry powder containing an amount of antibody suitable for a single administration, or in the form of a liquid.", "Dry powder unit dosage forms may be packaged in a kit with a syringe, a suitable quantity of diluent and/or other components useful for administration.", "Unit dosages in liquid form may be conveniently supplied in the form of a syringe pre-filled with a quantity of the anti-PD-1 antibody suitable for a single administration.", "The pharmaceutical compositions may also be supplied in bulk form containing quantities of anti-PD-1 antibody suitable for multiple administrations.", "Pharmaceutical compositions may be prepared for storage as lyophilized formulations or aqueous solutions by mixing an antibody having the desired degree of purity with optional pharmaceutically-acceptable carriers, excipients or stabilizers typically employed in the art (all of which are referred to herein as “carriers”), i.e., buffering agents, stabilizing agents, preservatives, isotonifiers, non-ionic detergents, antioxidants, and other miscellaneous additives.", "See, Remington's Pharmaceutical Sciences, 16th edition (Osol, ed.", "1980).", "Such additives should be nontoxic to the recipients at the dosages and concentrations employed.", "Buffering agents help to maintain the pH in the range which approximates physiological conditions.", "They may be present at a wide variety of concentrations, but will typically be present in concentrations ranging from about 2 mM to about 50 mM.", "Suitable buffering agents for use with the present disclosure include both organic and inorganic acids and salts thereof such as citrate buffers (e.g., monosodium citrate-disodium citrate mixture, citric acid-trisodium citrate mixture, citric acid-monosodium citrate mixture, etc.", "), succinate buffers (e.g., succinic acid-monosodium succinate mixture, succinic acid-sodium hydroxide mixture, succinic acid-disodium succinate mixture, etc.", "), tartrate buffers (e.g., tartaric acid-sodium tartrate mixture, tartaric acid-potassium tartrate mixture, tartaric acid-sodium hydroxide mixture, etc.", "), phosphate buffers (e.g., phosphoric acid-monosodium phosphate mixture, phosphoric acid-disodium phosphate mixture, monosodium phosphate-disodium phosphate mixture, etc.", "), gluconate buffers (e.g., gluconic acid-sodium gluconate mixture, gluconic acid-sodium hydroxide mixture, gluconic acid-potassium gluconate mixture, etc.", "), oxalate buffer (e.g., oxalic acid-sodium oxalate mixture, oxalic acid-sodium hydroxide mixture, oxalic acid-potassium oxalate mixture, etc.", "), lactate buffers (e.g., lactic acid-sodium lactate mixture, lactic acid-sodium hydroxide mixture, lactic acid-potassium lactate mixture, etc.)", "and acetate buffers (e.g., acetic acid-sodium acetate mixture, acetic acid-sodium hydroxide mixture, etc.).", "Additionally, fumarate buffers, histidine buffers and trimethylamine salts such as 2-amino-2-hydroxymethyl-propane-1,3-diol (i.e., Tris, THAM, or tris(hydroxymethyl)aminomethane) can be used.", "Isotonicifiers sometimes known as “stabilizers” can be added to ensure isotonicity of liquid compositions of the present disclosure and include polyhydric sugar alcohols, for example trihydric or higher sugar alcohols, such as glycerin, erythritol, arabitol, xylitol, sorbitol and mannitol.", "Stabilizers refer to a broad category of excipients which can range in function from a bulking agent to an additive which solubilizes the therapeutic agent or helps to prevent denaturation or adherence to the container wall.", "Typical stabilizers can be polyhydric sugar alcohols (enumerated above); amino acids such as arginine, lysine, glycine, glutamine, asparagine, histidine, alanine, ornithine, leucine, 2-phenylalanine, glutamic acid, threonine, etc., organic sugars or sugar alcohols, such as lactose, trehalose, stachyose, mannitol, sorbitol, xylitol, ribitol, myoinositol, galactitol, glycerol and the like, including cyclitols such as inositol; polyethylene glycol; amino acid polymers; sulfur containing reducing agents, such as urea, glutathione, thioctic acid, sodium thioglycolate, thioglycerol, α-monothioglycerol and sodium thiosulfate; low molecular weight polypeptides (e.g., peptides of 10 residues or fewer); hydrophilic polymers, such as polyvinylpyrrolidone monosaccharides, such as xylose, mannose, fructose, glucose; disaccharides such as lactose, maltose, sucrose and trehalose; and trisaccacharides such as raffinose; and polysaccharides such as dextran.", "Stabilizers may be present in amounts ranging from 0.5 to 10 weight % per weight of anti-PD-1 antibody.", "Non-ionic surfactants or detergents (also known as “wetting agents”) may be added to help solubilize the glycoprotein as well as to protect the glycoprotein against agitation-induced aggregation, which also permits the formulation to be exposed to shear surface stressed without causing denaturation of the protein.", "Suitable non-ionic surfactants include polysorbates (20, 80, etc.", "), poloxamers (184, 188 etc.", "), and pluronic polyols.", "Non-ionic surfactants may be present in a range of about 0.05 mg/mL to about 1.0 mg/mL.", "A specific exemplary embodiment of an aqueous composition suitable for administration via intravenous infusion comprises 20 mg/mL of an anti-PD-1 antibody comprising a heavy chain sequence of SEQ ID NO:51 or SEQ ID NO:52, and a light chain sequence of SEQ ID NO:61, 15 mM histidine pH 5.7, 8.0% (w/v) sucrose, and 0.05% (w/v) polysorbate 80.The composition may be in the form of a lyophilized powder that, upon reconstitution with sterile water or other solution suitable for injection or infusion (for example, 0.9% saline, Ringer's solution, lactated Ringer's solution, etc.)", "provides the above aqueous composition.", "The composition, or other embodiments of compositions, may also be in the form of a syringe or other device suitable for injection and/or infusion pre-filled with a quantity of composition suitable for a single administration of the anti-PD-1 antibody.", "7.6.Methods of Use 7.6.1.Therapeutic Benefit Data provided herein demonstrate that the disclosed anti-PD-1 antibodies antagonize PD-1 in the presence of cancer cells and exert potent anticancer activity against cancers such as solid tumors and blood malignancies in vivo.", "Accordingly, the anti-PD-1 antibodies, binding fragments, and/or pharmaceutical compositions comprising the anti-PD-1 antibodies may be used therapeutically to treat solid tumors or blood malignancies.", "In some embodiments, the method involves administering to a human patient having a solid tumor an amount of an anti-PD-1 antibody that antagonizes PD-1, and kills tumor cells at a rate effective to provide therapeutic benefit.", "Solid tumors that may be treated with the anti-PD-1 antibody include, but are not limited to, adrenal cancers, bladder cancers, bone cancers, brain cancers, breast cancers (e.g., triple negative breast cancer), cervical cancers, colorectal cancers, endometrial cancers, esophageal cancers, eye cancers, gastric cancers, head and neck cancers, kidney cancers (e.g., advanced renal cell carcinoma), liver cancers (e.g., hepatocellular carcinoma, cholangiocarcinoma), lung cancers (e.g., non-small cell lung cancer, mesothelioma, small cell lung cancer), head and neck cancers, melanomas (e.g., unresectable or metastatic melanoma, advanced malignant melanoma), oral cancers, ovarian cancers, penile cancers, prostate cancers, pancreatic cancers, skin cancers (e.g., Merkel cell carcinoma), testicular cancers, thyroid cancers, uterine cancers, vaginal cancers, and tumors with evidence of DNA mismatch repair deficiency.", "The cancers may be comprised of tumor cells that express PD-L1 or PD-L2, cancers comprised of tumor cells that do not express PD-L1 or PD-L2, or cancers comprised of tumor cells, some of which express PD-L1 or PD-L2 and some of which do not.", "The cancer may be newly diagnosed and naïve to treatment, or may be relapsed, refractory, or relapsed and refractory, or a metastatic form of a solid tumor.", "In some embodiments, the solid tumor is selected from bladder cancer, breast cancer, head and neck cancer, kidney cancer, lung cancer, lymphoma, melanoma, and gastric cancer.", "In some embodiments, the solid tumor is selected from: melanoma (e.g., unresectable or metastatic melanoma), lung cancer (e.g., non-small cell lung cancer), and renal cell carcinoma (e.g., advanced renal cell carcinoma).", "In some embodiments, the solid tumor is selected from triple negative breast cancer, ovarian cancer, hepatocellular carcinoma, gastric cancer, small cell lung cancer, mesothelioma, cholangiocarcinoma, Merkel cell carcinoma and tumors with evidence of DNA mismatch repair deficiency.", "In certain embodiments, the melanoma is BRAF V600 wild-type unresectable or metastatic melanoma.", "In other certain embodiments, the melanoma is BRAF V600 mutation-positive unresectable or metastatic melanoma.", "In certain embodiments, the lung cancer is metastatic non-small cell lung cancer with progression on or after platinum-based chemotherapy.", "In certain embodiments, the lung cancer is locally advanced or metastatic non-small cell lung cancer that has failed platinum-based therapy and is naïve to a PD-1 targeting agent.", "In certain embodiments, the head and neck cancer is metastatic (disseminated) head and neck squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx that is considered incurable by local therapies.", "In certain embodiments, the renal cell carcinoma is advanced renal cell carcinoma that has received prior anti-angiogenic therapy.", "In some embodiments, the method of the disclosure involves administering to a human patient having a blood malignancy an amount of an anti-PD-1 antibody that antagonizes PD-1, and kills malignant cells at a rate effective to provide therapeutic benefit.", "The cancers may be comprised of malignant cells that express PD-L1 or PD-L2, cancers comprised of malignant cells that do not express PD-L1 or PD-L2, or cancers comprised of malignant cells, some of which express PD-L1 or PD-L2 and some of which do not.", "The cancer may be newly diagnosed and naïve to treatment, or may be relapsed, refractory, or relapsed and refractory, or a metastatic form of a blood malignancy.", "Blood-borne malignancies that may be treated with the anti-PD-1 antibody include, but are not limited to, myelomas (e.g., multiple myeloma), lymphomas (e.g., Hodgkin's lymphoma, non-Hodgkin's lymphoma, Waldenström's macroglobulinemia, mantle cell lymphoma), leukemias (e.g., chronic lymphocytic leukemia, acute myeloid leukemia, acute lymphocytic leukemia), and myelodysplastic syndromes.", "As discussed above, the presently disclosed anti-PD-1 antibodies modulate an immunological response.", "Accordingly, patients having compromised immune systems may be excluded from treatment.", "In some embodiments, a patient is excluded after meeting one or more of the following criteria: (1) Active or prior documented autoimmune disease (including, but not limited to, inflammatory bowel disease, celiac disease, Wegener syndrome) within the past 2 years.", "(Subjects with childhood atopy or asthma, vitiligo, alopecia, Hashimoto syndrome, Grave's disease, or psoriasis not requiring systemic treatment (within the past 2 years) are not excluded); (2) History of primary immunodeficiency, bone marrow transplantation, chronic lymphocytic leukemia, solid organ transplantation, or previous clinical diagnosis of tuberculosis; (3) History of a coagulopathy or a platelet disorder; (4) Confirmed positive test results for human immunodeficiency virus (HIV), or subjects with chronic or active hepatitis B or C. (Subjects who have a history of hepatitis B or C who have documented cures after anti-viral therapy may be enrolled); (5) Prior grade ≥3 immune-mediated neurotoxicity or pneumonitis while receiving immunotherapy (including but not limited to agents directed against CTLA-4, PD-L1, or PD-1).", "In addition, any other prior grade ≥3 immune-mediated adverse event while receiving immunotherapy that has not resolved or become asymptomatic within 3 months; (6) Receipt of live, attenuated vaccine within 28 days prior to the first dose of the anti-PD-1 antibody.", "An anti-PD-1 antibody of the disclosure may be administered alone (monotherapy) or adjunctive to, or with, other anti-cancer therapies and/or targeted or non-targeted anti-cancer agents.", "When administered as an anti-PD-1 monotherapy, one or more antibodies may be used.", "Whether administered as monotherapy or adjunctive to, or with, other therapies or agents, an amount of anti-PD-1 antibody is administered such that the overall treatment regimen provides therapeutic benefit.", "By therapeutic benefit is meant that the use of anti-PD-1 antibodies to treat cancer in a patient results in any demonstrated clinical benefit compared with no therapy (when appropriate) or to a known standard of care.", "Clinical benefit can be assessed by any method known to one of ordinary skill in the art.", "In one embodiment, clinical benefit is assessed based on objective response rate (ORR) (determined using RECIST version 1.1), duration of response (DOR), progression-free survival (PFS), and/or overall survival (OS).", "In some embodiments, a complete response indicates therapeutic benefit.", "In some embodiments, a partial response indicates therapeutic benefit.", "In some embodiments, stable disease indicates therapeutic benefit.", "In some embodiments, an increase in overall survival indicates therapeutic benefit.", "In some embodiments, therapeutic benefit may constitute an improvement in time to disease progression and/or an improvement in symptoms or quality of life.", "In other embodiments, therapeutic benefit may not translate to an increased period of disease control, but rather a markedly reduced symptom burden resulting in improved quality of life.", "As will be apparent to those of skill in the art, a therapeutic benefit may be observed using the anti-PD-1 antibodies alone (monotherapy) or adjunctive to, or with, other anti-cancer therapies and/or targeted or non-targeted anti-cancer agents.", "Typically, therapeutic benefit is assessed using standard clinical tests designed to measure the response to a new treatment for cancer.", "To assess the therapeutic benefits of the anti-PD-1 antibodies described herein one or a combination of the following tests can be used: (1) the Response Evaluation Criteria In Solid Tumors (RECIST) version 1.1, (2) immune-related RECIST (irRECIST), (3) the Eastern Cooperative Oncology Group (ECOG) Performance Status, (4) immune-related response criteria (irRC), (5) disease evaluable by assessment of tumor antigens, (6) validated patient reported outcome scales, and/or (7) Kaplan-Meier estimates for overall survival and progression free survival.", "Assessment of the change in tumor burden is an important feature of the clinical evaluation of cancer therapeutics.", "Both tumor shrinkage (objective response) and time to the development of disease progression are important endpoints in cancer clinical trials.", "Standardized response criteria, known as RECIST (Response Evaluation Criteria in Solid Tumors), were published in 2000.An update (RECIST 1.1) was released in 2009.RECIST criteria are typically used in clinical trials where objective response is the primary study endpoint, as well as in trials where assessment of stable disease, tumor progression or time to progression analyses are undertaken because these outcome measures are based on an assessment of anatomical tumor burden and its change over the course of the trial.", "TABLE 4 provides the definitions of the response criteria used to determine objective tumor response to a study drug, such as the anti-PD-1 antibodies described herein.", "TABLE 4 Response Criteria Complete Response Disappearance of all target lesions.", "Any pathological lymph nodes (CR) (whether target or non-target) must have reduction in short axis to <10 mm.", "Partial Response At least a 30% decrease in the sum of diameters of target lesions, taking as (PR) reference the baseline sum diameters.", "Progressive Disease At least a 20% increase in the sum of diameters of target lesions, taking as (PD) reference the smallest sum on study (this includes the baseline sum if that is the smallest on study).", "In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm.", "(Note: the appearance of one or more new lesions is also considered progression).", "Stable Disease Neither sufficient shrinkage to qualify for PR nor sufficient increase to (SD) qualify for PD, taking as reference the smallest sum diameters while on study.", "Secondary outcome measures that can be used to determine the therapeutic benefit of the anti-PD-1 antibodies described herein include, Objective Response Rate (ORR), Progression Free Survival (PFS), Overall Survival (OS), Duration of Overall Response (DOR), and Depth of Response (DpR).", "ORR is defined as the proportion of the participants who achieve a complete response (CR) or partial response (PR).", "PFS is defined as the time from the first dose date of an anti-PD-1 antibody to either disease progression or death, whichever occurs first.", "OS is defined as the length of time from either the date of diagnosis or the start of treatment for a disease, that patients diagnosed with the disease are still alive.", "DOR is defined as the time from the participant's initial CR or PR to the time of disease progression.", "DpR is defined as the percentage of tumor shrinkage observed at the maximal response point compared to baseline tumor load.", "Clinical endpoints for both ORR and PFS can be determined based on RECIST 1.1 criteria described above.", "Additional criteria that may be used for clinical evaluation specific to cancer patients undergoing immune therapy treatment include the standardized immune-related RECIST (irRECIST) criteria.", "See, e.g., Nishino, M. et al.", "Eur.", "J.", "Radiol., 84(7), pages 1259-1268 (2015 July).", "These guidelines modified the RECIST 1.1 criteria above with consideration of potential immunomodulatory effects.", "TABLE 5 provides the definitions of the response criteria used to determine objective tumor response to an immunomodulatory drug, such as the anti-PD-1 antibodies described herein.", "TABLE 5 Response Criteria Complete Response Complete disappearance of all measurable and non-measurable lesions.", "(irCR) Lymph nodes must decrease to <10 mm in short axis.", "Partial Response Decrease of ≤30% in total measured tumor burden relative to baseline, (irPR) non-target lesions are irNN, and no unequivocal progression of new non- measurable lesions Progressive Disease At least a 20% increase and at least 5 mm absolute increase in TMTB (irPD) compared to nadir, or irPD for non-target or new non-measurable lesions.", "Confirmation of progression is recommended at least 4 weeks after the first irPD assessment.", "Non-irCR or non- No target disease was identified at baseline and at follow-up the patient irPD (irNN) fails to meet criteria for irCR or irPD Stable Disease Neither sufficient shrinkage to qualify for irPR nor sufficient increase to (irSD) qualify for irPD, taking as reference the smallest sum diameters while on study.", "irNE Used in exceptional cases where insufficient data exists.", "The ECOG Scale of Performance Status shown in TABLE 6 is used to describe a patient's level of functioning in terms of their ability to care for themselves, daily activity, and physical ability.", "The scale was developed by the Eastern Cooperative Oncology Group (ECOG), now part of the ECOG-ACRIN Cancer Research Group, and published in 1982.TABLE 6 Grade ECOG Performance Status 0 Fully active, able to carry on all pre-disease performance without restriction 1 Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work 2 Ambulatory and capable of all selfcare but unable to carry out any work activities; up and about more than 50% of waking hours 3 Capable of only limited selfcare; confined to bed or chair more than 50% of waking hours 4 Completely disabled; cannot carry on any selfcare; totally confined to bed or chair 5 Dead Another set of criteria that can be used to characterize fully and to determine response to immunotherapeutic agents, such as antibody-based cancer therapies, is the immune-related response criteria (irRC), which was developed for measurement of solid tumors in 2009, and updated in 2013 (Wolchok, et al.", "Clin.", "Cancer Res.", "2009; 15(23): 7412-7420 and Nishino, et al.", "Clin.", "Cancer Res.", "2013; 19(14): 3936-3943).", "The updated irRC criteria are typically used to assess the effect of an immunotherapeutic agent, such as an anti-PD-1 antibody described herein, on tumor burden, and defines response according to TABLE 7.TABLE 7 Response Criteria Complete Response Disappearance of all target lesions in two consecutive observations not less (CR) than 4 weeks apart Partial Response At least a 30% decrease in the sum of the longest diameters of target (PR) lesions, taking as reference the baseline sum diameters.", "Progressive Disease At least a 20% increase in the sum of diameters of target lesions, taking as (PD) reference the smallest sum on study (this includes the baseline sum if that is the smallest on study).", "(Note: the appearance of one or more new lesions is not considered progression.", "The measurement of new lesions is included in the sum of the measurements).", "Stable Disease Neither sufficient shrinkage to qualify for PR nor sufficient increase to (SD) qualify for PD, taking as reference the smallest sum diameters while on study.", "Tumor antigens that can be used to evaluate the therapeutic benefit of the anti-PD-1 antibodies described herein include ApoE, CD11c, CD40, CD45 (PTPRC), CD49D (ITGA4), CD80, CSF1R, CTSD, GZMB, Ly86, MS4A7, PIK3AP1, PIK3CD, CD74, CCL5, CCR5, CXCL10, IFNG, IL10RA1, IL-6, ACTA2, COL7A1, LOX, LRRC15, MCPT8, MMP10, NOG, SERPINE1, STAT1, TGFBR1, CTSS, PGF, VEGFA, C1QA, C1QB, ANGPTL4, EGLN, ANGPTL4, EGLN3, BNIP3, AIF1, CCL5, CXCL10, CXCL11, IFI6, PLOD2, KISS1R, STC2, DDIT4, OX40, OX40L, PFKFB3, PGK1, PDK1, AKR1C1, AKR1C2, CADM1, CDH11, COL6A3, CTGF, HMOX1, KRT33A, LUM, WNT5A, IGFBP3, MMP14, CDCP1, PDGFRA, TCF4, TGF, TGFB1, TGFB2, CD11b, ADGRE1 (EMR1, F4/80), CD86, CD68, MHC-Class II, CD3, HLA-DR, CD4, CD3, CD5, CD19, CD7, CD8, CD16, TCRαβ, TCRγδ, PD-1, PD-L1, CTLA-4, acid phosphatase, ACTH, alkaline phosphatase, alpha-fetoprotein CA-125, CA15-3, CA19-9, CA-195, C-212, CA-549, calcitonin, catecholamines, cathepsin-D, CEA, ERBB2 (HER2/neu), chromagranin-A, c-Myc, EGFR, ERA (estrogen receptor assay), ferritin, gastrin, 5-HIAA, hCG, alpha-HCG, beta-HCG, HVA, LDH1-5, NSE (neuron specific enolase), pancreatic polypeptide, PLAP, PLP, PRA (progesterone receptor A), proinsulin C-peptide, PSA, SMA, SCC, thyroglobulin, TDT, TPA, and alpha-TSH.", "These tumor antigens can be assessed at the DNA, RNA or protein level using DNA sequencing techniques, RNA sequencing techniques, gene chip microarray, PCR based methods, flow cytometry or immunohistochemistry methods as known to experts in the art.", "One exemplary therapeutic benefit resulting from the use of anti-PD-1 antibodies described herein to treat solid tumors, whether administered as monotherapy or adjunctive to, or with, other therapies or agents, is a complete response.", "Another exemplary therapeutic benefit resulting from the use of anti-PD-1 antibodies described herein to treat solid tumors, whether administered as monotherapy or adjunctive to, or with, other therapies or agents, is a partial response.", "Validated patient reported outcome scales can also be used to denote response provided by each patient through a specific reporting system.", "Rather than being disease focused, such outcome scales are concerned with retained function while managing a chronic condition.", "One non-limiting example of a validated patient reported outcome scale is PROMIS® (Patient Reported Outcomes Measurement Information System) from the United States National Institutes of Health.", "For example, PROMIS® Physical Function Instrument for adult cancer patients can evaluate self-reported capabilities for the functioning of upper extremities (e.g., dexterity), lower extremities (e.g., walking or mobility), and central regions (e.g., neck, back mobility), and includes routine daily activities, such as running errands.", "Kaplan-Meier curves (Kaplan and Meier, J.", "Am.", "Stat.", "Assoc.", "1958; 53(282): 457-481) can also be used to estimate overall survival and progression free survival for cancer patients undergoing anti-PD-1 antibody therapy in comparison to standard of care.", "7.6.2.Adjunctive Therapies The anti-PD-1 antibodies may be used adjunctive to, or with, other agents or treatments having anti-cancer properties.", "When used adjunctively, the anti-PD-1 antibody and other agent(s) may be formulated together in a single, combination pharmaceutical formulation, or may be formulated and administered separately, either on a single coordinated dosing regimen or on different dosing regimens.", "Agents administered adjunctive to or with the anti-PD-1 antibodies will typically have complementary activities to the anti-PD-1 antibodies such that the antibodies and other agents do not adversely affect each other.", "Agents that may be used adjunctively with anti-PD-1 antibodies include, but are not limited to, alkylating agents, angiogenesis inhibitors, antibodies, antimetabolites, antimitotics, antiproliferatives, antivirals, aurora kinase inhibitors, apoptosis promoters (for example, Bcl-2 family inhibitors), activators of death receptor pathway, Bcr-Abl kinase inhibitors, BiTE (Bi-Specific T cell Engager) antibodies, antibody drug conjugates, biologic response modifiers, Bruton's tyrosine kinase (BTK) inhibitors, cyclin-dependent kinase inhibitors, cell cycle inhibitors, cyclooxygenase-2 inhibitors, DVDs, leukemia viral oncogene homolog (ErbB2) receptor inhibitors, growth factor inhibitors, heat shock protein (HSP)-90 inhibitors, histone deacetylase (HDAC) inhibitors, hormonal therapies, immunologicals, inhibitors of inhibitors of apoptosis proteins (IAPs), intercalating antibiotics, kinase inhibitors, kinesin inhibitors, Jak2 inhibitors, mammalian target of rapamycin inhibitors, microRNAs, mitogen-activated extracellular signal-regulated kinase inhibitors, multivalent binding proteins, non-steroidal anti-inflammatory drugs (NSAIDs), poly ADP (adenosine diphosphate)-ribose polymerase (PARP) inhibitors, platinum chemotherapeutics, polo-like kinase (Plk) inhibitors, phosphoinositide-3 kinase (PI3K) inhibitors, proteasome inhibitors, purine analogs, pyrimidine analogs, receptor tyrosine kinase inhibitors, retinoids/deltoids plant alkaloids, small inhibitory ribonucleic acids (siRNAs), topoisomerase inhibitors, ubiquitin ligase inhibitors, and the like, as well as combinations of one or more of these agents.", "BiTE antibodies are bispecific antibodies that direct T-cells to attack cancer cells by simultaneously binding the two cells.", "The T-cell then attacks the target cancer cell.", "Examples of BiTE antibodies include adecatumumab (Micromet MT201), blinatumomab (Micromet MT103) and the like.", "Without being limited by theory, one of the mechanisms by which T-cells elicit apoptosis of the target cancer cell is by exocytosis of cytolytic granule components, which include perforin and granzyme B. SiRNAs are molecules having endogenous RNA bases or chemically modified nucleotides.", "The modifications do not abolish cellular activity, but rather impart increased stability and/or increased cellular potency.", "Examples of chemical modifications include phosphorothioate groups, 2′-deoxynucleotide, 2′-OCH3-containing ribonucleotides, 2′-F-ribonucleotides, 2′-methoxyethyl ribonucleotides, combinations thereof and the like.", "The siRNA can have varying lengths (e.g., 10-200 bps) and structures (e.g., hairpins, single/double strands, bulges, nicks/gaps, mismatches) and are processed in cells to provide active gene silencing.", "A double-stranded siRNA (dsRNA) can have the same number of nucleotides on each strand (blunt ends) or asymmetric ends (overhangs).", "The overhang of 1-2 nucleotides can be present on the sense and/or the antisense strand, as well as present on the 5′- and/or the 3′-ends of a given strand.", "Multivalent binding proteins are binding proteins comprising two or more antigen binding sites.", "Multivalent binding proteins are engineered to have the three or more antigen binding sites and are generally not naturally occurring antibodies.", "The term “multispecific binding protein” means a binding protein capable of binding two or more related or unrelated targets.", "Dual variable domain (DVD) binding proteins are tetravalent or multivalent binding proteins binding proteins comprising two or more antigen binding sites.", "Such DVDs may be monospecific (i.e., capable of binding one antigen) or multispecific (i.e., capable of binding two or more antigens).", "DVD binding proteins comprising two heavy chain DVD polypeptides and two light chain DVD polypeptides are referred to as DVD Ig's.", "Each half of a DVD Ig comprises a heavy chain DVD polypeptide, a light chain DVD polypeptide, and two antigen binding sites.", "Each binding site comprises a heavy chain variable domain and a light chain variable domain with a total of 6 CDRs involved in antigen binding per antigen binding site.", "Alkylating agents include, but are not limited to, altretamine, AMD-473, AP-5280, apaziquone, bendamustine, brostallicin, busulfan, carboquone, carmustine (BCNU), chlorambucil, CLORETAZINE® (laromustine, VNP 40101M), cyclophosphamide, dacarbazine, estramustine, fotemustine, glufosfamide, ifosfamide, KW-2170, lomustine (CCNU), mafosfamide, melphalan, mitobronitol, mitolactol, nimustine, nitrogen mustard N-oxide, ranimustine, temozolomide, thiotepa, TREANDA® (bendamustine), treosulfan, and trofosfamide.", "Angiogenesis inhibitors include, but are not limited to, endothelial-specific receptor tyrosine kinase (Tie-2) inhibitors, epidermal growth factor receptor (EGFR) inhibitors, vascular endothelial growth factor receptor (VEGF) inhibitors, delta-like ligand 4 (DLL4) inhibitors, insulin growth factor-2 receptor (IGFR-2) inhibitors, matrix metalloproteinase-2 (MMP-2) inhibitors, matrix metalloproteinase-9 (MMP-9) inhibitors, platelet-derived growth factor receptor (PDGFR) inhibitors, thrombospondin analogs, and vascular endothelial growth factor receptor tyrosine kinase (VEGFR) inhibitors.", "Antibody drug conjugates include, but are not limited to, those that target c-Met kinase (e.g., ADCs described in U.S. Pat.", "No.", "7,615,529), LRRC15, CD30 (e.g., ADCETRIS® (brentuximab vedotin)), CS1 (e.g., ADCs described in US publication no.", "20160122430), DLL3 (e.g., rovalpituzumab tesirine (ROVA-T)), HER2 (e.g., KADCYLA® (trastuzumab emtansine)), EGFR (e.g., ADCs described in US publication no.", "20150337042), and prolactin receptor (e.g., ADCs described in US publication no.", "20140227294).", "Antimetabolites include, but are not limited to, ALIMTA® (pemetrexed disodium, LY231514, MTA), 5-azacitidine, XELODA® (capecitabine), carmofur, LEUSTAT® (cladribine), clofarabine, cytarabine, cytarabine ocfosfate, cytosine arabinoside, decitabine, deferoxamine, doxifluridine, eflornithine, EICAR (5-ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide), enocitabine, ethnylcytidine, fludarabine, 5-fluorouracil alone or in combination with leucovorin, GEMZAR® (gemcitabine), hydroxyurea, ALKERAN® (melphalan), mercaptopurine, 6-mercaptopurine riboside, methotrexate, mycophenolic acid, nelarabine, nolatrexed, ocfosfate, pelitrexol, pentostatin, raltitrexed, ribavirin, triapine, trimetrexate, S-1, tiazofurin, tegafur, TS-1, vidarabine, and UFT.", "Antivirals include, but are not limited to, ritonavir, acyclovir, cidofovir, ganciclovir, foscarnet, zidovudine, ribavirin, and hydroxychloroquine.", "Aurora kinase inhibitors include, but are not limited to, ABT-348, AZD-1152, MLN-8054, VX-680, Aurora A-specific kinase inhibitors, Aurora B-specific kinase inhibitors and pan-Aurora kinase inhibitors.", "Bcl-2 protein inhibitors include, but are not limited to, ABT-263 (navitoclax), AT-101 ((−)gossypol), GENASENSE® (G3139 or oblimersen (Bcl-2-targeting antisense oligonucleotide)), IPI-194, IPI-565, N-(4-(4-((4′-chloro(1,1′-biphenyl)-2-yl)methyl)piperazin-1-yl)benzoyl)-4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl)amino)-3-nitrobenzene sulfonamide), N-(4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohex-1-en-1-yl)methyl)piperazin-1-yl)benzoyl)-4-(((1R)-3-(morpholin-4-yl)-1-((phenylsulfanyl)methyl)propyl)amino)-3-((trifluoromethyl)sulfonyl)benzene sulfonamide, venetoclax and GX-070 (obatoclax).", "Bcr-Abl kinase inhibitors include, but are not limited to, DASATINIB® (BMS-354825) and GLEEVEC® (imatinib).", "BTK inhibitors include, but are not limited to, ibrutinib and acalabrutinib.", "CDK inhibitors include, but are not limited to, AZD-5438, BMI-1040, BMS-032, BMS-387, CVT-2584, flavopyridol, GPC-286199, MCS-5A, PD0332991, PHA-690509, seliciclib (CYC-202, R-roscovitine), and ZK-304709.COX-2 inhibitors include, but are not limited to, ABT-963, ARCOXIA® (etoricoxib), BEXTRA® (valdecoxib), BMS347070, CELEBREX® (celecoxib), COX-189 (lumiracoxib), CT-3, DERAMAXX® (deracoxib), JTE-522, 4-methyl-2-(3,4-dimethylphenyl)-1-(4-sulfamoylphenyl-1H-pyrrole), MK-663 (etoricoxib), NS-398, parecoxib, RS-57067, SC-58125, SD-8381, SVT-2016, S-2474, T-614, and VIOXX® (rofecoxib).", "EGFR inhibitors include, but are not limited to, ABX-EGF, anti-EGFR immunoliposomes, EGF-vaccine, EMD-7200, ERBITUX® (cetuximab), HR3, IgA antibodies, IRESSA® (gefitinib), TARCEVA® (erlotinib or OSI-774), TAGRISSO® (osimertinib), TP-38, EGFR fusion protein, and TYKERB® (lapatinib).", "ErbB2 receptor inhibitors include, but are not limited to, CP-724-714, CI-1033 (canertinib), HERCEPTIN® (trastuzumab), TYKERB® (lapatinib), OMNITARG® (2C4, pertuzumab), TAK-165, GW-572016 (ionafarnib), GW-282974, EKB-569, PI-166, dHER2 (HER2 vaccine), APC-8024 (HER-2 vaccine), anti-HER/2neu bispecific antibody, B7.her2IgG3, AS HER2 trifunctional bispecific antibodies, mAB AR-209, and mAB 2B-1.Histone deacetylase inhibitors include, but are not limited to, depsipeptide, LAQ-824, MS-275, trapoxin, suberoylanilide hydroxamic acid (SAHA), TSA, and valproic acid.", "HSP-90 inhibitors include, but are not limited to, 17-AAG-nab, 17-AAG, CNF-101, CNF-1010, CNF-2024, 17-DMAG, geldanamycin, IPI-504, KOS-953, MYCOGRAB® (human recombinant antibody to HSP-90), NCS-683664, PU24FC1, PU-3, radicicol, SNX-2112, STA-9090, and VER49009.Inhibitors of apoptosis proteins include, but are not limited to, HGS1029, GDC-0145, GDC-0152, LCL-161, and LBW-242.Activators of death receptor pathway include, but are not limited to, TRAIL, antibodies or other agents that target TRAIL or death receptors (e.g., DR4 and DR5) such as Apomab, conatumumab, ETR2-ST01, GDC0145 (lexatumumab), HGS-1029, LBY-135, PRO-1762 and trastuzumab.", "Kinesin inhibitors include, but are not limited to, Eg5 inhibitors such as AZD4877, ARRY-520; and CENPE inhibitors such as GSK923295A.", "JAK-2 inhibitors include, but are not limited to, CEP-701 (lesaurtinib), XL019 and INCB018424.MEK inhibitors include, but are not limited to, ARRY-142886, ARRY-438162, PD-325901, and PD-98059.mTOR inhibitors include, but are not limited to, AP-23573, CCI-779, everolimus, RAD-001, rapamycin, temsirolimus, ATP-competitive TORC1/TORC2 inhibitors, including PI-103, PP242, PP30, and Torin 1.Non-steroidal anti-inflammatory drugs include, but are not limited to, AMIGESIC® (salsalate), DOLOBID® (diflunisal), MOTRIN® (ibuprofen), ORUDIS® (ketoprofen), RELAFEN® (nabumetone), FELDENE® (piroxicam), ibuprofen cream, ALEVE® (naproxen) and NAPROSYN® (naproxen), VOLTAREN® (diclofenac), INDOCIN® (indomethacin), CLINORIL® (sulindac), TOLECTIN® (tolmetin), LODINE® (etodolac), TORADOL® (ketorolac), and DAYPRO® (oxaprozin).", "PDGFR inhibitors include, but are not limited to, C-451, CP-673 and CP-868596.Platinum chemotherapeutics include, but are not limited to, cisplatin, ELOXATIN® (oxaliplatin) eptaplatin, lobaplatin, nedaplatin, PARAPLATIN® (carboplatin), satraplatin, and picoplatin.", "Polo-like kinase inhibitors include, but are not limited to, BI-2536.Phosphoinositide-3 kinase (PI3K) inhibitors include, but are not limited to, wortmannin, LY294002, XL-147, CAL-120, ONC-21, AEZS-127, ETP-45658, PX-866, GDC-0941, BGT226, BEZ235, and XL765.Thrombospondin analogs include, but are not limited to, ABT-510, ABT-567, ABT-898, and TSP-1.VEGFR inhibitors include, but are not limited to, ABT-869, AEE-788, ANGIOZYME™ (a ribozyme that inhibits angiogenesis (Ribozyme Pharmaceuticals (Boulder, Colo.) and Chiron (Emeryville, Calif.)), axitinib (AG-13736), AZD-2171, CP-547,632, CYRAMZA® (ramucirumab), IM-862, MACUGEN® (pegaptamib), NEXAVAR® (sorafenib, BAY43-9006), pazopanib (GW-786034), vatalanib (PTK-787, ZK-222584), SUTENT® (sunitinib, SU-11248), STIVARGA® (regorafenib), VEGF trap, and ZACTIMA™ (vandetanib, ZD-6474).", "Antibiotics include, but are not limited to, intercalating antibiotics aclarubicin, actinomycin D, amrubicin, annamycin, adriamycin, BLENOXANE® (bleomycin), daunorubicin, CAELYX® or MYOCET® (liposomal doxorubicin), elsamitrucin, epirbucin, glarbuicin, ZAVEDOS® (idarubicin), mitomycin C, nemorubicin, neocarzinostatin, peplomycin, pirarubicin, rebeccamycin, stimalamer, streptozocin, VALSTAR® (valrubicin), and zinostatin.", "Topoisomerase inhibitors include, but are not limited to, aclarubicin, 9-aminocamptothecin, amonafide, amsacrine, becatecarin, belotecan, BN-80915, CAMPTOSAR® (irinotecan hydrochloride), camptothecin, CARDIOXANE® (dexrazoxine), diflomotecan, edotecarin, ELLENCE® or PHARMORUBICIN® (epirubicin), etoposide, exatecan, 10-hydroxycamptothecin, gimatecan, lurtotecan, mitoxantrone, Onivyde™ (liposomal irinotecan), orathecin, pirarbucin, pixantrone, rubitecan, sobuzoxane, SN-38, tafluposide, and topotecan.", "Antibodies include, but are not limited to, AVASTIN® (bevacizumab), CD40-specific antibodies, chTNT-1/B, denosumab, ERBITUX® (cetuximab), HUMAX-CD4® (zanolimumab), IGF1R-specific antibodies, lintuzumab, OX-40 specific antibodies, PANOREX® (edrecolomab), RENCAREX® (WX G250), RITUXAN® (rituximab), ticilimumab, trastuzumab, pertuzumab, VECTIBIX® (panitumumab) and CD20 antibodies types I and II.", "Hormonal therapies include, but are not limited to, ARIMIDEX® (anastrozole), AROMASIN® (exemestane), arzoxifene, CASODEX® (bicalutamide), CETROTIDE® (cetrorelix), degarelix, deslorelin, DESOPAN® (trilostane), dexamethasone, DROGENIL® (flutamide), EVISTA® (raloxifene), AFEMA™ (fadrozole), FARESTON® (toremifene), FASLODEX® (fulvestrant), FEMARA® (letrozole), formestane, glucocorticoids, HECTOROL® (doxercalciferol), RENAGEL® (sevelamer carbonate), lasofoxifene, leuprolide acetate, MEGACE® (megesterol), MIFEPREX® (mifepristone), NILANDRON™ (nilutamide), NOLVADEX® (tamoxifen citrate), PLENAXIS™ (abarelix), prednisone, PROPECIA® (finasteride), rilostane, SUPREFACT® (buserelin), TRELSTAR® (luteinizing hormone releasing hormone (LHRH)), VANTAS® (Histrelin implant), VETORYL® (trilostane or modrastane), and ZOLADEX® (fosrelin, goserelin).", "Deltoids and retinoids include, but are not limited to, seocalcitol (EB1089, CB1093), lexacalcitrol (KH1060), fenretinide, PANRETIN® (aliretinoin), ATRAGEN® (liposomal tretinoin), TARGRETIN® (bexarotene), and LGD-1550.PARP inhibitors include, but are not limited to, ABT-888 (veliparib), KU-59436, AZD-2281 (olaparib), AG-014699 (rucaparib), MK4827 (niraparib), BMN-673 (talazoparib), iniparib, BSI-201, BGP-15, INO-1001, and ONO-2231.Plant alkaloids include, but are not limited to, vincristine, vinblastine, vindesine, and vinorelbine.", "Proteasome inhibitors include, but are not limited to, VELCADE® (bortezomib), KYPROLIS® (carfilzomib), MG132, NPI-0052, and PR-171.Examples of immunologicals include, but are not limited to, interferons, immune checkpoint inhibitors, co-stimulatory agents, and other immune-enhancing agents.", "Interferons include interferon alpha, interferon alpha-2a, interferon alpha-2b, interferon beta, interferon gamma-1a, ACTIMMUNE® (interferon gamma-1b) or interferon gamma-n1, combinations thereof and the like.", "Immune check point inhibitors include antibodies that target PD-L1 (e.g., durvalumab, atezolizumab, avelumab, MEDI4736, MSB0010718C and MPDL3280A), and CTLA4 (cytotoxic lymphocyte antigen 4; e.g., ipilimumab, tremelimumab).", "Co-stimulatory agents include, but are not limited to, antibodies against CD3, CD40, CD40L, CD27, CD28, CSF1R, CD137 (e.g., urelumab), B7H1, GITR, ICOS, CD80, CD86, OX40, OX40L, CD70, HLA-DR, LIGHT, LIGHT-R, TIM3, A2AR, NKG2A, KIR (e.g., lirilumab), TGF-β (e.g., fresolimumab) and combinations thereof.", "Other agents include, but are not limited to, ALFAFERONE® (IFN-α), BAM-002 (oxidized glutathione), BEROMUN® (tasonermin), BEXXAR® (tositumomab), CAMPATH® (alemtuzumab), dacarbazine, denileukin, epratuzumab, GRANOCYTE® (lenograstim), lentinan, leukocyte alpha interferon, imiquimod, melanoma vaccine, mitumomab, molgramostim, MYLOTARG™ (gemtuzumab ozogamicin), NEUPOGEN® (filgrastim), OncoVAC-CL, OVAREX® (oregovomab), pemtumomab (Y-muHMFG1), PROVENGE® (sipuleucel-T), sargaramostim, sizofilan, teceleukin, THERACYS® (Bacillus Calmette-Guerin), ubenimex, VIRULIZIN® (immunotherapeutic, Lorus Pharmaceuticals), Z-100 (Specific Substance of Maruyama (SSM)), WF-10 (Tetrachlorodecaoxide (TCDO)), PROLEUKIN® (aldesleukin), ZADAXIN® (thymalfasin), ZINBRYTA® (daclizumab high-yield process), and ZEVALIN® (90Y-Ibritumomab tiuxetan).", "Biological response modifiers are agents that modify defense mechanisms of living organisms or biological responses, such as survival, growth or differentiation of tissue cells to direct them to have anti-tumor activity and include, but are not limited to, krestin, lentinan, sizofiran, picibanil PF-3512676 (CpG-8954), and ubenimex.", "Pyrimidine analogs include, but are not limited to, cytarabine (ara C or Arabinoside C), cytosine arabinoside, doxifluridine, FLUDARA® (fludarabine), 5-FU (5-fluorouracil), floxuridine, GEMZAR® (gemcitabine), TOMUDEX® (ratitrexed), and TROXATYL™ (triacetyluridine troxacitabine).", "Purine analogs include, but are not limited to, LANVIS® (thioguanine) and PURINETHOL® (mercaptopurine).", "Antimitotic agents include, but are not limited to, batabulin, epothilone D (KOS-862), N-(2-((4-hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide, ixabepilone (BMS 247550), TAXOL® (paclitaxel), TAXOTERE® (docetaxel), PNU100940 (109881), patupilone, XRP-9881 (larotaxel), vinflunine, and ZK-EPO (synthetic epothilone).", "Ubiquitin ligase inhibitors include, but are not limited to, MDM2 inhibitors, such as nutlins, and NEDD8 inhibitors such as MLN4924.Anti-PD-1 antibodies may also be used to enhance the efficacy of radiation therapy.", "Examples of radiation therapy include external beam radiation therapy, internal radiation therapy (i.e., brachytherapy) and systemic radiation therapy.", "Anti-PD-1 antibodies may be administered adjunctive to or with other chemotherapeutic agents such as ABRAXANE™ (ABI-007), ABT-100 (farnesyl transferase inhibitor), ADVEXIN® (Ad5CMV-p53 vaccine), ALTOCOR® or MEVACOR® (lovastatin), AMPLIGEN® (poly I:poly C12U, a synthetic RNA), APTOSYN® (exisulind), AREDIA® (pamidronic acid), arglabin, L-asparaginase, atamestane (1-methyl-3,17-dione-androsta-1,4-diene), AVAGE® (tazarotene), AVE-8062 (combreastatin derivative) BEC2 (mitumomab), cachectin or cachexin (tumor necrosis factor), canvaxin (vaccine), CEAVAC® (cancer vaccine), CELEUK® (celmoleukin), CEPLENE® (histamine dihydrochloride), CERVARIX® (human papillomavirus vaccine), CHOP® (C: CYTOXAN® (cyclophosphamide); H: ADRIAMYCIN® (hydroxydoxorubicin); O: Vincristine (ONCOVIN®); P: prednisone), CYPAT™ (cyproterone acetate), combrestatin A4P, DAB(389)EGF (catalytic and translocation domains of diphtheria toxin fused via a His-Ala linker to human epidermal growth factor) or TransMID-107R™ (diphtheria toxins), dacarbazine, dactinomycin, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), eniluracil, EVIZON™ (squalamine lactate), DIMERICINE® (T4N5 liposome lotion), discodermolide, DX-8951f (exatecan mesylate), enzastaurin, EPO906 (epithilone B), GARDASIL® (quadrivalent human papillomavirus (Types 6, 11, 16, 18) recombinant vaccine), GASTRIMMUNE®, GENASENSE®, GMK (ganglioside conjugate vaccine), GVAX® (prostate cancer vaccine), halofuginone, histrelin, hydroxycarbamide, ibandronic acid, IGN-101, IL-13-PE38, IL-13-PE38QQR (cintredekin besudotox), IL-13-pseudomonas exotoxin, interferon-α, interferon-γ, JUNOVAN™ or MEPACT™ (mifamurtide), lonafarnib, 5,10-methylenetetrahydrofolate, miltefosine (hexadecylphosphocholine), NEOVASTAT® (AE-941), NEUTREXIN® (trimetrexate glucuronate), NIPENT® (pentostatin), ONCONASE® (a ribonuclease enzyme), ONCOPHAGE® (melanoma vaccine treatment), ONCOVAX® (IL-2 Vaccine), ORATHECIN™ (rubitecan), OSIDEM® (antibody-based cell drug), OVAREX® MAb (murine monoclonal antibody), paclitaxel, PANDIMEX™ (aglycone saponins from ginseng comprising 20(S)protopanaxadiol (aPPD) and 20(S)protopanaxatriol (aPPT)), panitumumab, PANVAC®-VF (investigational cancer vaccine), pegaspargase, PEG Interferon A, phenoxodiol, procarbazine, rebimastat, REMOVAB® (catumaxomab), REVLIMID® (lenalidomide), RSR13 (efaproxiral), SOMATULINE® LA (lanreotide), SORIATANE® (acitretin), staurosporine (Streptomyces staurospores), talabostat (PT100), TARGRETIN® (bexarotene), TAXOPREXIN® (DHA-paclitaxel), TELCYTA® (canfosfamide, TLK286), temilifene, TEMODAR® (temozolomide), tesmilifene, thalidomide, THERATOPE® (STn-KLH), thymitaq (2-amino-3,4-dihydro-6-methyl-4-oxo-5-(4-pyridylthio)quinazoline dihydrochloride), TNFERADE™ (adenovector: DNA carrier containing the gene for tumor necrosis factor-α), TRACLEER® or ZAVESCA® (bosentan), tretinoin (Retin-A), tetrandrine, TRISENOX® (arsenic trioxide), VIRULIZIN®, ukrain (derivative of alkaloids from the greater celandine plant), vitaxin (anti-alphavbeta3 antibody), XCYTRIN® (motexafin gadolinium), XINLAY™ (atrasentan), XYOTAX™ (paclitaxel poliglumex), YONDELIS® (trabectedin), ZD-6126, ZINECARD® (dexrazoxane), ZOMETA® (zolendronic acid), and zorubicin, as well as combinations of any of these agents.", "In some embodiments, an anti-PD-1 antibody is administered adjunctive to or with an antibody-drug conjugate targeting c-Met kinase for treating non-small cell lung cancer, head and neck cancer, pancreatic cancer, colorectal cancer, or gastric cancer.", "In some embodiments, an anti-PD-1 antibody is administered adjunctive to or with an antibody-drug conjugate targeting LRRC15 for treating non-small cell lung cancer, head and neck cancer, pancreatic cancer, sarcoma, triple negative breast cancer, or melanoma.", "In some embodiments, an anti-PD-1 antibody is administered adjunctive to or with an antibody-drug conjugate targeting EGFR for treating glioblastoma.", "In some embodiments, an anti-PD-1 antibody is administered adjunctive to or with an antibody-drug conjugate targeting CS1 for treating a blood malignancy such as multiple myeloma.", "In some embodiments, an anti-PD-1 antibody is administered adjunctive to or with an antibody-drug conjugate targeting DLL3 for treating small cell lung cancer or glioblastoma.", "In some embodiments, an anti-PD-1 antibody is administered adjunctive to or with an anti-CD40 protein for treating head and neck cancer, lung cancer (such as adenocarcinoma, non-small cell lung cancer, mesothelioma, small cell lung cancer), melanoma, ovarian cancer or pancreatic cancer.", "In some embodiments, an anti-PD-1 antibody is administered adjunctive to or with venetoclax for treating a blood malignancy such as chronic lymphocytic leukemia.", "In some embodiments, an anti-PD-1 antibody is administered adjunctive to or with ibrutinib for treating a blood malignancy, such as chronic lymphocytic leukemia, mantle cell lymphoma, or Waldenström's macroglobulinemia, or a solid tumor.", "In some embodiments, an anti-PD-1 antibody is administered adjunctive to or with ipilimumab and an antibody-drug conjugate targeting c-Met kinase for treating non-small cell lung cancer.", "In some embodiments, an anti-PD-1 antibody is administered adjunctive to or with ipilimumab and an antibody-drug conjugate targeting LRRC15 for treating non-small cell lung cancer.", "7.7.Dosages and Administration Regimens The amount of anti-PD-1 antibodies administered will depend upon a variety of factors, including but not limited to, the particular type of solid tumor treated, the stage of the solid tumor being treated, the mode of administration, the frequency of administration, the desired therapeutic benefit, and other parameters such as the age, weight and other characteristics of the patient, etc.", "Determination of dosages effective to provide therapeutic benefit for specific modes and frequency of administration is within the capabilities of those skilled in the art.", "Dosages effective to provide therapeutic benefit may be estimated initially from in vivo animal models or clinical.", "Suitable animal models for a wide variety of diseases are known in the art.", "The anti-PD-1 antibodies disclosed herein may be administered by any route appropriate to the condition to be treated.", "In some embodiments, the anti-PD-1 antibody is any one of the humanized antibodies listed in TABLE 3.In a specific embodiment, the anti-PD-1 antibody has a heavy chain according to SEQ ID NO:51 or SEQ ID NO:52, and a light chain according to SEQ ID NO:61.An anti-PD-1 antibody will typically be administered parenterally, i.e., infusion, subcutaneous, intramuscular, intravenous (IV), intradermal, intrathecal, bolus, intratumoral injection or epidural ((Shire et al., 2004, J. Pharm.", "Sciences 93(6):1390-1402)).", "In one embodiment, an anti-PD-1 antibody is provided as a lyophilized powder in a vial.", "The vials may contain 100 mg, 110 mg, 120 mg, 150 mg, 200 mg, 250 mg, 300 mg, or 400 mg of anti-PD-1 antibody.", "Prior to administration, the lyophilized powder is reconstituted with sterile water for injection (SWFI) or other suitable medium to provide a solution containing 20 mg/mL anti-PD-1 antibody.", "In some embodiments, the resulting reconstituted solution is further diluted with saline or other suitable medium for infusion and administered via an IV infusion twice every 7 days, once every 7 days, once every 14 days, once every 21 days, once every 28 days, once every 35 days, once every 42 days, once every 49 days, or once every 56 days.", "In some embodiments, for the first cycle, the infusion occurs over 90 minutes.", "In some embodiments, subsequent infusions are over 60 minutes.", "In some embodiments, the anti-PD-1 antibody is administered as an IV infusion once every 7 days at 0.1 mg/kg, 0.5 mg/kg, 1.0 mg/kg, 2.0 mg/kg, 3.0 mg/kg, 4.0 mg/kg, 5.0 mg/kg, 6.0 mg/kg, 8.0 mg/kg, or 10.0 mg/kg.", "In some embodiments, the anti-PD-1 antibody is administered as an IV infusion once every 14 days at 0.1 mg/kg, 0.5 mg/kg, 1.0 mg/kg, 2.0 mg/kg, 3.0 mg/kg, 4.0 mg/kg, 5.0 mg/kg, 6.0 mg/kg, 8.0 mg/kg, or 10.0 mg/kg.", "In some embodiments, the anti-PD-1 antibody is administered as an IV infusion once every 21 days at 0.1 mg/kg, 0.5 mg/kg, 1.0 mg/kg, 2.0 mg/kg, 3.0 mg/kg, 4.0 mg/kg, 5.0 mg/kg, 6.0 mg/kg, 8.0 mg/kg, or 10.0 mg/kg.", "In some embodiments, the anti-PD-1 antibody is administered as an IV infusion once every 28 days at 0.1 mg/kg, 0.5 mg/kg, 1.0 mg/kg, 2.0 mg/kg, 3.0 mg/kg, 4.0 mg/kg, 5.0 mg/kg, 6.0 mg/kg, 8.0 mg/kg, or 10.0 mg/kg.", "In one exemplary embodiment, an anti-PD-1 antibody is used adjunctive to ipilimumab (YERVOY®) to treat non-small cell lung cancer.", "The anti-PD-1 antibody is administered via IV infusion once every 21 days at 1.0 mg/kg or 3.0 mg/kg.", "Ipilimumab is administered by intravenous infusion at a dose of 1 mg/kg once every three weeks for four doses.", "Subsequent to the last ipilimumab dose, the anti-PD-1 antibody is administered via IV infusion once every 14 days at 1.0 mg/kg or 3.0 mg/kg.", "The adjunctive anti-PD-1 antibody/ipilimumab therapy is continued until disease progression or no longer tolerated by the patient.", "In one exemplary embodiment, an anti-PD-1 antibody is used adjunctive to ipilimumab (YERVOY®) to treat non-small cell lung cancer.", "The anti-PD-1 antibody is administered via IV infusion once every 14 days at 1.0 mg/kg or 3.0 mg/kg.", "Ipilimumab is administered by intravenous infusion at a dose of 1 mg/kg once every six weeks for four doses.", "The adjunctive anti-PD-1 antibody/ipilimumab therapy is continued until disease progression or no longer tolerated by the patient.", "In one exemplary embodiment, an anti-PD-1 antibody is used adjunctive to ipilimumab (YERVOY®) to treat non-small cell lung cancer.", "The anti-PD-1 antibody is administered via IV infusion once every 14 days at 1.0 mg/kg or 3.0 mg/kg.", "Ipilimumab is administered by intravenous infusion at a dose of 1 mg/kg once every twelve weeks for four doses.", "The adjunctive anti-PD-1 antibody/ipilimumab therapy is continued until disease progression or no longer tolerated by the patient.", "When administered adjunctive to or with other agents, such as other chemotherapeutic agents, the anti-PD-1 antibodies may be administered on the same schedule as the other agent(s), or on a different schedule.", "When administered on the same schedule, the anti-PD-1 antibody may be administered before, after, or concurrently with the other agent.", "In some embodiments where an anti-PD-1 antibody is administered adjunctive to, or with, standards of care, the anti-PD-1 antibody may be initiated prior to commencement of the standard therapy, for example a day, several days, a week, several weeks, a month, or even several months before commencement of standard of care therapy.", "In some embodiments where an anti-PD-1 antibody is administered adjunctive to, or with, standards of care, the anti-PD-1 antibody may be initiated after commencement of the standard therapy, for example a day, several days, a week, several weeks, a month, or even several months after commencement of standard of care therapy.", "As will be appreciated by those of skill in the art, the recommended dosages for the various agents described above may need to be adjusted to optimize patient response and maximize therapeutic benefit.", "7.8.Exemplary Embodiments The following are exemplary enumerated embodiments of the present disclosure.", "1.An anti-PD-1 binding protein which comprises (i) a VH chain comprising three CDRs; and (ii) a VL chain comprising three CDRs, wherein: VH CDR#1 is GYTFTHYGMN (SEQ ID NO:11); VH CDR#2 is WVNTYTGEPTYADDFKG (SEQ ID NO:12); VH CDR#3 is EGEGLGFGD (SEQ ID NO:13); VL CDR#1 is RSSQSIVHSHGDTYLE (SEQ ID NO:14); VL CDR#2 is KVSNRFS (SEQ ID NO:15); and VL CDR#3 is FQGSHIPVT (SEQ ID NO:16).", "2.The anti-PD-1 binding protein of embodiment 1, which comprises a VH chain corresponding in sequence to SEQ ID NO:31; and a VL chain corresponding in sequence to SEQ ID NO:41.3.The anti-PD-1 binding protein of embodiment 1, which is humanized.", "4.The anti-PD-1 binding protein of embodiment 3, which comprises a VH chain corresponding in sequence to SEQ ID NO:36; and a VL chain corresponding in sequence to SEQ ID NO:42.5.An anti-PD-1 binding protein which comprises (i) a VH chain comprising three CDRs; and (ii) a VL chain comprising three CDRs, wherein: VH CDR#1 is GYTFTHYGMN (SEQ ID NO:11); VH CDR#2 is WVNTYTGEPTYADDFKG (SEQ ID NO:12); VH CDR#3 is EGEGMGFGD (SEQ ID NO:23); VL CDR#1 is RSSQSIVHSHGDTYLE (SEQ ID NO:14); VL CDR#2 is KVSNRFS (SEQ ID NO:15); and VL CDR#3 is FQGSHIPVT (SEQ ID NO:16).", "6.The anti-PD-1 binding protein of embodiment 5, which comprises a VH chain corresponding in sequence to SEQ ID NO:33; and a VL chain corresponding in sequence to SEQ ID NO:42.7.The anti-PD-1 binding protein of any one of embodiments 1 to 6, which is an IgG.", "8.The anti-PD-1 binding protein of embodiment 7, which is an IgG1, optionally comprising a variant CH2 domain comprising the amino acid substitutions L234A and L235A.", "9.The anti-PD-1 binding protein of embodiment 7, which is an IgG4, optionally comprising a variant Fc region comprising the amino acid substitution S228P.", "10.The anti-PD-1 binding protein of embodiment 8 which comprises a heavy chain corresponding to the sequence of SEQ ID NO:51 or SEQ ID NO:52, and a light chain corresponding to the sequence of SEQ ID NO:61.11.The anti-PD-1 binding protein of any one of embodiments 1 to 10 which has a KD of less than about 100 nM.", "12.The anti-PD-1 binding protein of embodiment 11 which has a KD of less than about 10 nM.", "13.A pharmaceutical composition comprising the anti-PD-1 binding protein of any one of embodiments 1 to 12, and a pharmaceutically acceptable carrier.", "14.A nucleic acid comprising a nucleotide sequence encoding the anti-PD-1 binding protein of any one of embodiments 1 to 12.15.A vector comprising the nucleic acid of embodiment 14.16.A prokaryotic host cell transformed with the vector of embodiment 15.17.A eukaryotic host cell transformed with the vector of embodiment 15.18.A eukaryotic host cell engineered to express the nucleic acid of embodiment 14.19.The eukaryotic host cell of embodiment 18 which is a mammalian host cell.", "20.A method of producing an anti-PD-1 binding protein thereof, comprising: (a) culturing the host cell of embodiment 17 or embodiment 18 and (b) recovering the anti-PD-1 binding protein.", "21.A method of activating the immune system, comprising administering to a patient in need thereof the anti-PD-1 binding protein of any one of embodiments 1 to 12, or the pharmaceutical composition according to embodiment 13.22.A method of treating a cancer, comprising administering to a patient in need thereof the anti-PD-1 binding protein of any one of embodiments 1 to 12, or the pharmaceutical composition according to embodiment 13.23.The method of embodiment 22, wherein the cancer is selected from bladder cancer, breast cancer, head and neck cancer, kidney cancer, lung cancer, lymphoma, melanoma, and stomach cancer.", "24.The method of embodiment 23, wherein the lung cancer is non-small cell lung cancer.", "25.The method of embodiment 22, in which the anti-PD-1 binding protein is administered as a monotherapy.", "26.The method of embodiment 22, in which the anti-PD-1 binding protein is administered adjunctive to or with another agent commonly used to treat the cancer.", "27.The method of embodiment 26, in which the other agent is selected from radiation, chemotherapy, an antibody drug conjugate, an anti-CD40 antibody, an anti-CTLA-4 antibody and an anti-OX40 antibody.", "28.The method of embodiment 27, in which the chemotherapy is cisplatin, carboplatin, paclitaxel, docetaxel, gemcitabine, vinorelbine, vinblastine, irinotecan, etoposide, or pemetrexed, or a pharmaceutically acceptable salt thereof.", "29.The method of embodiment 27, in which the antibody drug conjugate targets c-Met kinase.", "30.The method of embodiment 27, in which the antibody drug conjugate targets LRRC15.31.The method of embodiment 27, in which the antibody drug conjugate targets EGFR.", "32.The method of embodiment 27, in which the antibody drug conjugate targets CS1.33.The method of embodiment 27, in which the antibody drug conjugate is rovalpituzumab tesirine.", "34.The method of embodiment 27, in which the anti-CTLA-4 antibody is ipilimumab.", "8.EXAMPLES The following Examples, which highlight certain features and properties of embodiments of the anti-PD-1 antibodies described herein are provided for purposes of illustration, and not limitation.", "Example 1: Materials and Methods 8.1.1.Antibody Binding to Plate Bound Human PD-1 by ELISA Immunolon 4×HB 96 well plates were coated with 1 ug/ml of human PD-1 Fc fusion in at 4° C. overnight.", "Plates were blocked with PBS containing 1% BSA for 30 minutes at room temperature and then washed three times with PBS containing 0.1% Tween 20 (PBST) using a plate washer.", "PD-1-coated plates were then incubated with indicated concentrations of antibodies at room temperature (RT) for one hour.", "Plates were washed four times with PBST and then incubated for 1 hour at room temperature with 100 μL of goat anti-human Fab fragment specific-biotin prepared to a dilution of 1:5000 in PBS containing 1% BSA.", "Plates were washed five times in PBST and 100 μL of a 1:1000 dilution of Streptavidin-HRP was added to each well and incubated for 30 minutes at RT.", "Plates were washed five times in PBST and 100 μL of TMB One Component were added to each well and incubated at RT until color developed (approximately 5-10 minutes).", "Optical density (OD) was read at 650 nm using Spectromax190 (Molecular Devices).", "8.1.2.Antibody Binding to Cell Surface Expressed Human PD-1 PD-1 expressing Jurkat cells were harvested from flasks and resuspended to 2×106 cells/mL in PBS containing 1% BSA.", "100 μL of cells were added to a round bottom 96 well plate containing 100 μL of titrated test antibody or isotype control.", "Cells were incubated with antibodies at room temperature for 25 minutes and then washed twice with PBS containing 1% BSA.", "The cell pellet was resuspended in 100 μL of a 1:250 diluted secondary antibody goat anti-human Fab PE.", "Following 25 minutes incubation at RT, cells were washed twice with PBS containing 1% BSA and resuspended in 200 μL of 1% BSA.", "Cells were analyzed using Becton Dickinson FACSCanto flow cytometer.", "Data was analyzed using BD FACSDiva software (version 8.0.1).", "8.1.3.Antibody Binding to Plate Bound Cynomolgus Monkey PD-1 by ELISA Immunolon 4×HB 96-well plates were coated with 1 μg/mL of cynomolgus PD-1 Fc fusion in DPBS at 4° C. overnight.", "Plates were blocked with PBS containing 1% BSA for 30 minutes at RT and then washed three times with PBST (PBS Tween 20 0.1%) using a plate washer.", "PD-1-coated plates were then incubated with indicated concentrations of antibodies at room temperature for one hour.", "Plates were washed four times with PBST and then incubated for 1 hour at RT with 100 μL of goat anti-human Fab fragment specific biotin prepared to a dilution of 1:5000 in PBS containing 1% BSA.", "Plates were washed five times in PBST and 100 μL of a 1:1000 dilution of Streptavidin-HRP was added to each well and incubated for 30 minutes at RT.", "Plates were subsequently washed five times in PBST and 100 μL of TMB.", "One component was added to each well and incubated at RT until color developed (approximately 5-10 minutes).", "Optical density (OD) was read at 650 nm using a Spectromax190 (Molecular Devices).", "8.1.4.Antibody Binding to Activated Human CD4+ T Cells Human peripheral blood mononuclear cells (PBMCs) were isolated from buffy coats purchased from Stanford Blood Center (Palo Alto, Calif.).", "Briefly, buffy coats were diluted in a 1:1 ratio with PBS without magnesium and calcium.", "Diluted blood (30 mL) was layered over 15 mL of 90% Ficoll-Paque Plus prepared in PBS without magnesium and calcium contained in SepMate tubes.", "The tubes were spun at 1200 g for 10 minutes.", "The interphase was collected and washed twice in 1× PBS.", "PBMC were cultured at 2×106 cells/mL for 48 hrs in RPMI media containing 10% HI FCS with 1 μg/mL PHA and 50 U/mL recombinant human IL-2.The cells were collected, washed and incubated with antibodies at RT for 25 minutes.", "Labeled cells were washed twice with PBS containing 1% BSA.", "Cells were resuspended in 100 μL of PBS+1% BSA and a 1:250 dilution of PE conjugated goat anti-human Fab fragment and anti-CD4-FITC were added.", "After 30 minutes, cells were washed twice with PBS containing 1% BSA and resuspended in 200 μL of 1% BSA.", "Cells were analyzed using Becton Dickinson FACSCanto flow cytometer.", "Data was analyzed using BD FACSDiva software (version 8.0.1).", "8.1.5.Binding Affinity for PD-1 by Surface Plasmon Resonance The binding kinetics of anti-PD-1 antibodies for recombinant soluble PD-1 ECD (extracellular domain) were determined by surface plasmon resonance-based measurements made on Biacore T200 instrument at 25° C. using an anti-Fc capture assay approach.", "Recombinant extracellular domains of human PD-1 (residues 1-167) and cynomolgus PD-1 (residues 21-167) were purchased from a commercial source and further purified by gel filtration in 10 mM HEPES, pH 7.4, 150 mM NaCl, 3 mM EDTA.", "Chip preparation and binding kinetic measurements were made in the assay buffer HBS-EP+(10 mM HEPES, pH 7.4, 150 mM NaCl, 3 mM EDTA, 0.05% Tween 20).", "For anti-Fc capture chip preparation, approximately 2000 RU of goat anti-human IgG Fc polyclonal antibody diluted to 25 μg/mL in 10 mM sodium acetate (pH 4.5), was directly immobilized across a CMS biosensor chip using a standard amine coupling kit according to manufacturer's instructions and procedures.", "Unreacted moieties on the biosensor surface were blocked with ethanolamine.", "For binding kinetics measurements, each assay cycle comprises the following steps: (1) capture of test antibody on test surface only; (2) analyte injection (PD-1 ECD or buffer only) over both reference and test surface, 240 μL at 80 μL/min, after which the dissociation was monitored for 900 seconds at 80 μL/min; and (3) regeneration of capture surface by 10 mM glycine hydrochloride, pH 1.5 injections over both reference and test surface.", "During the assay, all measurements were referenced against the capture surface alone (i.e., with no captured test antibody) and buffer-only injections were used for double referencing.", "PD-1 injections ranged in concentration from 900 nM to 11.1 nM in a randomized 3-fold dilution series.", "Data were processed and fitted globally to a 1:1 binding model using Biacore T200 Evaluation software to determine the binding kinetic rate constants, ka (M−1·sec−1) and kd (sec−1), and the equilibrium dissociation constant KD (M).", "8.1.6.Blocking of PD-1 Interaction with PD-L1 and PD-L2 Human PD-lexpressing HEK 293G cells were harvested from confluent flasks.", "Cells were resuspended in PBS at a concentration of 2×106 cells/mL.", "Cells (1×105) were added to each well of a 96-well V bottom plate and cells were blocked for 15 min at 4° C. using human FcR block.", "In separate plates, test antibodies and isotype control solutions were prepared using a 3-fold serial dilution of the 20 μg/mL starting concentration.", "Cells were washed in 1×PBS and 50 μL of the prepared antibody dilutions and 50 μL of the PD-L1 His-tagged or PD-L2 His-tagged ligands (10 μg/ml) were added to the plate containing cells.", "Cells were incubated at 4° C. for 30 minutes and washed twice with 1×PBS.", "Anti-His APC antibody (50 μL) prepared at a dilution of 1:50 in PBS was added to each well and incubated for 30 minutes at 4° C. The cells were washed twice, resuspended in PBS and acquired on LSR II Fortessa (BD Biosciences, San Jose, Calif.).", "8.1.7.Allogeneic Human Mixed Lymphocyte Reaction (MLR) Assay Using Purified CD4 T Cells and Dendritic Cells Human PBMCs were isolated from buffy coats purchased from Stanford Blood Center (Palo Alto, Calif.).", "Briefly, buffy coats were diluted in a 1:1 ratio with PBS without magnesium and calcium.", "Diluted blood (30 mL) was layered over 15 mL of 90% Ficoll-Paque Plus prepared in PBS without magnesium and calcium contained in SepMate tubes.", "The tubes were spun at 1200 g for 10 minutes.", "The interphase was collected and washed twice in 1×PBS.", "Cells were resuspended at 1×108 per mL in AIM-V media containing beta mercaptoethanol.", "Dendritic cells (DCs) were derived by culturing plastic adherent PBMCs in T75 flasks in the presence of 80 ng/mL GM-CSF and 50 ng/mL IL-4 for 7 days.", "On day 5, 50 pg/mL IL-1α and 200 pg/mL TNF-α was added to the DC cultures.", "On day 7, DCs were harvested from flasks, irradiated for 7.3 minutes at 414 R/min, and resuspended to a final concentration of 1×105 cells/mL in complete media (RPMI with L Glutamine containing 10% FBS, 1× non-essential vitamins, 1% Pen/Strep solution, 1% sodium pyruvate, 1% HEPES).", "Allogeneic human CD4 T cells were isolated using the CD4 T cell isolation kit.", "DCs (1×104/well) and purified CD4 T cells (1×105/well) were added to a U bottom plate.", "Test antibody or isotype control (10 μg/mL) was added to the plate containing DCs and T cells.", "After five days of incubation, supernatant was collected and analyzed for IL-2 and IFN-γ using Milliplex cytometric bead array kit.", "IFN-γ was measured using BioRad Bioplex System (Bioplex manager 6.0).", "8.1.8.Antigen Recall Response to Tetanus Toxoid Human PBMCs were isolated from buffy coats purchased from Stanford Blood Center as previously described.", "Cells were resuspended to a final concentration of 2×106 cells/mL in AIM-V media containing beta mercaptoethanol.", "PBMCs (2×105) were used per well with 0.2 μg/mL tetanus toxoid.", "Antibody was titrated and the plates were incubated for five days.", "Supernatants were collected on day 5 and assessed for IFN-γ using a Milliplex cytometric bead array kit.", "IFN-γ was measured using BioRad Bioplex System (Bioplex manager 6.0).", "Example 2: Generation and Humanization of Mouse Anti-PD-1 Antibodies Mice were immunized according to the methods known in the art (E. Harlow, D. Lane.", "Antibody: A Laboratory Manual, (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1998)).", "Isotype of each monoclonal antibody was determined using the Mouse Isotyping kit (Roche).", "Hybridoma clones producing antibodies of interest were purified and further characterized for affinity by surface plasmon resonance and ligand competition (ELISA).", "Cloning and construction of the expression vector were accomplished by methods known in the art for expression of recombinant monoclonal antibodies.", "Humanization of the antibody V region was carried out as outlined by Queen, C. et al.", "(Proc.", "Natl.", "Acad.", "Sci.", "USA, 1989; 86:10029-10033).", "The canonical structures of the CDRs were determined according to Huang et al.", "(Methods, 2005; 36:35-42).", "Human variable germline sequences with the same or most similar CDR canonical structures were identified, and appropriate human VH, VL, and J segment sequences were selected to provide the frameworks for the anti-PD-1 variable region.", "At framework positions in which the computer model suggested significant contact with the CDRs, the amino acids from the murine anti-PD-1 V regions were substituted for the original human framework amino acids (back-mutations).", "Full amino acid sequences of the VH and VL regions of exemplary mouse and humanized antibodies are shown in FIG.", "2.Anti-PD-1 mouse antibody Mu12A11 was humanized according to the method described above.", "The humanized versions of Mu12A11 VH were Hu12A11.1b VH and Hu12A11.2b VH.", "Hu12A11.1b VH had VH 7-4-1 framework regions, with four back mutations of V2I, M48V, F67L, and A93T.", "Hu12A11.2b VH had VH 1-69 framework regions, with seven back mutations of V2I, M48V, V67L, I69F, A71L, E73T, and A93T.", "Either of the two humanized VH could be combined with humanized light chain Hu12A11.1a VL which had VL 2-28 framework regions, with one back mutation of I2V.", "Example 3: Stability of the Anti-PD-1 Antibodies Stability of exemplary antibodies were determined by measuring PD-1 binding of the antibodies after treatment under oxidative or variable temperature conditions.", "An assessment of liability motifs identified a conserved methionine residue at Kabat position 99 (M99) that was believed to be both solvent exposed and prone to deamidation.", "Samples of the M99 parent antibody Hu12A11.2b1 were exposed to accelerated degradation conditions to enhance potential deamidation (FIG.", "3A).", "The samples treated with 1% hydrogen peroxide (1% HP) or 1% tert-butyl hydroperoxide (1% TBHP) demonstrated loss of binding affinity, suggesting the potential for oxidation of the methionine-99 residue.", "A set of antibodies containing point mutations at position M99 were constructed, including isoleucine (M99I, Hu12A11.2b2 having a VH according to SEQ ID NO:34), valine (M99V, Hu12A11.2b3 having a VH according to SEQ ID NO:35), and leucine (M99L, Hu12A11.2b4 having a VH according to SEQ ID NO:36) mutations.", "The antibody variants were screened for binding to human PD-1 transfected Jurkat cells and EC50 values were determined (FIG.", "3B).", "All three point mutation-containing antibodies bound to cell surface PD-1 similarly, but the M99L variant antibody showed higher binding activity as compared to M99V or M99I variants.", "The M99L variant Hu12A11.2b4 was found to retain fully binding capacity after temperature stability testing (FIG.", "3C).", "Incubation of Hu12A11.2b4 at −80, 5, 25, or 40° C. afforded no significant loss of activity in terms of EC50 or maximal fluorescence intensity (MFI).", "Example 4: Binding Affinity of the Anti-PD-1 Antibodies Table 4-1 below shows in vitro binding affinity data of exemplary antibody Hu12A11.2b4 in comparison to literature anti-PD-1 antibody nivolumab prepared according to the procedures found in U.S. Pat.", "No.", "9,073,994.Hu12A11.2b4 exhibited similar binding properties to PD-1 as compared to nivolumab according to surface plasmon resonance, ELISA assay with human (Hu) or cynomolgus (Cyno) PD-1, or in human Jurkat cells as measured in the assays of Example 1.TABLE 4-1 Binding Properties of Select Antibodies against PD-1 Hu ELISA Hu ELISA Cyno SPR EC50 OD650 ELISA Hu Jurkat Antibody KD (M)* (pM) max EC50 (pM) EC50 (pM) Nivolumab 2.9E−09 101 2.2 70 56 Hu12A11.2b4 2.1E−09 197 2.9 102 45 *SPR = surface plasmon resonance as determined according to Example 1; exponential notation shown (e.g., 3.0E−09 = 3.0 × 10−9).", "Example 5: Biological Activity of Anti-PD-1 Antibody Hu12A11.2b4 Hu12A11.2b4 was evaluated for biological activity in a number of in vitro human cell assays described in Example 1.As shown in Table 5-1, Hu12A11.2b4 demonstrated 180 pM binding to PD-1 in CD4+ T cells.", "In addition, the anti-PD-1 activity of Hu12A11.2b4 was shown to be mediated at least in part by its ability to block PD-L1 or PD-L2 interaction with PD-1 as assessed by flow cytometry.", "This biological activity was consistent with the activity of Hu12A11.2b4 in recombinant Jurkat T cells expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of human PD-1 (Jurkat NFAT assay).", "TABLE 5-1 Biological Activity of Exemplary anti-PD-1 Antibodies CD4+ T-cell PD-L1 PD-L2 binding blocking blocking Jurkat NFAT Antibody EC50 (pM) (μg/mL) (μg/mL) EC50 (μg/mL) Nivolumab 180 0.106 0.233 15 ± 20 Hu12A11.2b4 180 0.045 0.132 4.5 ± 6.5 Anti-PD-1 antibody Hu12A11.2b4 further demonstrated an enhancement in immunological response in in vitro assays.", "As shown in FIG.", "4A, treatment with 10 μg/mL of Hu12A11.2b4 in mixed leukocyte cultures effected a significant increase in IL-2 as well as an IFN-γ increase of about 7.4-fold.", "FIG.", "4B shows that Hu12A11.2b4 exhibited a tetanus toxoid recall response of about 6-fold over no antibody treatment at 10 μg/mL, with an EC50=161 ng/mL.", "The in vitro biological activity observed for Hu12A11.2b4 was similar to that measured for the nivolumab used in Example 4.With respect to immunological response, the comparison antibody nivolumab exhibited an IFN-γ increase of about 5.6-fold in MLR, and a tetanus toxoid recall response of about 6-fold over no antibody treatment at 10 μg/mL, with an EC50=218 ng/mL.", "All publications, patents, patent applications and other documents cited in this application are hereby incorporated by reference in their entireties for all purposes to the same extent as if each individual publication, patent, patent application or other document were individually indicated to be incorporated by reference for all purposes.", "While various specific embodiments have been illustrated and described, it will be appreciated that various changes can be made without departing from the spirit and scope of the invention(s)." ] ]
Patent_15875970
[ [ "METHOD AND SYSTEM FOR PORTIONING WORKPIECES USING REFERENCE SHAPE AS A DIRECTLY CONTROLLED CHARACTERISTIC", "A method and system are provided for automatically portioning workpieces, such as food products, by simulating portioning the workpieces in accordance with the one or more desired shapes of the final piece(s) as a directly controlled physical characteristic (parameter/specification) as well as one or more resulting indirectly controlled physical characteristics (parameters/specifications).", "The desired shape(s) of the final piece(s) are defined by a plurality of manipulatable reference coordinates.", "A workpiece is scanned to obtain scanning information, then portioning of the workpiece is simulated in accordance with the desired shape(s) of the final piece(s) defined by the directly controlled reference coordinates, thereby to determine the one or more indirectly controlled physical characteristics of the one or more final pieces to be portioned from the workpiece.", "The simulated portioning of the workpiece is performed for multiple combinations of directly controlled shapes as defined by the modified or edited reference coordinates and indirectly controlled physical characteristics until an acceptable set of a directly controlled shape and resulting one or more indirectly controlled physical characteristics is determined." ], [ "1.A method of automatically portioning a food product into one or more final pieces based on an adjustable two-dimensional reference shape plus at least one additional physical criteria for the one or more final pieces, comprising: (a) using a user-interface to select an adjustable two-dimensional reference shape into which a food product is to be portioned, the adjustable two-dimensional reference shape being defined by a plurality of specified discrete points located along an outline of the adjustable two-dimensional reference shape, wherein the outline of the adjustable two-dimensional reference shape is displayed on an output display; (b) permitting a user to optionally edit the user-entered, adjustable two-dimensional reference shape comprising using the user-interface to move the outline of the user-entered two-dimensional reference shape as displayed on the output display, to result in a change of the shape of the two-dimensional reference shape as shown on the output display of: (c) retaining data pertaining to the two-dimensional reference shape in computer memory; (d) selecting at least one additional physical criteria, in addition to the adjustable two-dimensional reference shape, used to portion the food product into one or more final pieces, said at least one additional physical criteria selected from the group consisting of: the weight of the final piece; the maximum weight of the final piece; the minimum weight of the final piece; the length of the final piece; the maximum length of the final piece; the minimum length of the final piece; the width of the final piece, the maximum width of the final piece; the minimum width of the final piece; the height of the final piece; the maximum height of the final piece, the minimum height of the final piece, the thickness of the final piece, the maximum thickness of the final piece; the minimum thickness of the final piece; (e) determining a cut path to portion the food product into one or more final pieces having the user-entered two-dimensional reference shape as retained in the computer memory and as optionally edited by the user and meeting the at least one additional selected physical criteria of the one or more final pieces; and (f) portioning the food product into one or more final pieces according to the determined cut path.", "2.The method of claim 1, comprising changing the shape of the two-dimensional reference shape as shown on the output display by a technique selected from the group consisting of: (a) selecting one or more locations along the two-dimensional outline of the reference shape and using the user-interface system to move the one or more selected locations to a new location shown on the output display, thereby to edit the shape of the adjustable two-dimensional reference shape as shown on the output display; and (b) selecting one or more of locations along the outline of the two-dimensional reference shape as shown on the output display and using the user-interface to specify new locations for said one or more selected locations along the outline of the two-dimensional reference shape, thereby to edit the shape of the adjustable two-dimensional reference shape shown on the output display.", "3.The method of claim 1, wherein the user-interface system comprises a scanner system, and step (a) comprises scanning in the adjustable two-dimensional reference shape using the scanner system.", "4.The method of claim 3, wherein the adjustable two-dimensional reference shape is formed of a food product or food product simulation material that has been cut or formed into the reference shape.", "5.The method of claim 1, wherein the user using the user-interface system selects the adjustable two-dimensional reference shape from a library of reference shapes.", "6.The method of claim 1, wherein the user-interface system is configured to allow a user to draw an outline of the adjustable two-dimensional reference shape.", "7.The method of claim 1, wherein the user-interface system is configured to allow a user to enter the X and Y coordinate locations along an outline of the adjustable two-dimensional reference shape in X-Y space.", "8.The method of claim 1, wherein step (e) of determining a cut path comprises scaling up or down the size of the adjustable two-dimensional reference shape on a food product while maintaining the shape of the adjustable two-dimensional reference shape until a predetermined weight or weight range for the portioned food product is achieved.", "9.A system for automatically portioning a food product into one or more final pieces based on an adjustable two-dimensional reference shape and at least one additional physical criteria of the one or more final pieces, comprising: a cutter for portioning the food product; and a processor coupled to the cutter, the processor being associated with a memory and user interface system, and controlled by computer-executable instructions for performing the steps of: (a) permitting a user to enter, using the user interface system, an adjustable two-dimensional reference shape into which a food product is to be portioned, (b) permitting a user to optionally edit the user-entered, adjustable two-dimensional reference shape by manipulating an outline of the user-entered, adjustable two-dimensional reference shape as displayed on the user-interface system, the user permitted to use the user-interface system to alter the outline of the user-entered, adjustable two-dimensional reference shape thereby to change the shape of the two-dimensional reference shape, while shown on the user interface system, (c) recording the user entered and optionally user edited, the two-dimensional reference shape in the memory; (d) selecting at least one additional physical criteria for the one or more final pieces in addition to the adjustable two-dimensional reference shape used to portion the food product into one or more final pieces selected from the group consisting of: the weight of the final piece; the maximum weight of the final piece; the minimum weight of the final piece; the length of the final piece; the maximum length of the final piece; the minimum length of the final piece; the width of the final piece, the maximum width of the final piece; the minimum width of the final piece; the height of the final piece; the maximum height of the final piece, the minimum height of the final piece, the thickness of the final piece, the maximum thickness of the final piece; the minimum thickness of the final piece; (e) determining a cut path to portion the food product into one or more final pieces having the user entered two-dimensional reference shape as recorded in the memory and as optionally edited by the user and meeting the at least one additional selected physical criteria of the one or more final pieces in addition to the adjustable two-dimensional reference shape used to portion the food product; and (f) controlling the cutter to portion the food product according to the determined cut path.", "10.The system of claim 9, permitting the user to alter the two-dimensional reference shape, as shown on the output display, by a technique selected from the group consisting of: (a) selecting one or more locations along the outline of the two-dimensional reference shape shown on the output display and using the user-interface system to move the one or more specified locations along the outline to a new location shown on the output display, thereby to edit the shape of the adjustable two-dimensional reference shape; and (b) selecting one or more locations along the outline of the adjustable two-dimensional reference shape shown on the output display and using the user-interface system to specify new locations for said one or more selected locations thereby to edit the shape of the adjustable two-dimensional reference shape while shown on the output display.", "11.The system of claim 9, wherein the user-interface system comprises a scanner system, and step (a) comprises scanning in an adjustable two-dimensional reference shape using the scanner system.", "12.The system of claim 9, wherein the user using the user-interface system selects a two-dimensional reference shape from a library of reference shapes.", "13.The system of claim 9, wherein the user-interface device is configured to allow a user to draw an outline of the adjustable two-dimensional reference shape.", "14.The system of claim 9, wherein the user-interface device is configured to allow a user to enter the X and Y coordinate locations along the outline of the adjustable two-dimensional reference shape in X-Y space.", "15.The system of claim 9, further comprising scaling up or down the size of the adjustable two-dimensional reference shape on a food product while maintaining the shape of the adjustable two-dimensional reference shape until a predetermined weight or weight range for the portioned food product is achieved.", "16.A non-transitory computer-readable medium including computer-executable instructions for portioning a food product into one or more final pieces based on an adjustable two-dimensional reference shape and at least one additional physical parameter of the one or more final pieces, said instructions which, when loaded onto a computer cause the computer to perform the steps comprising: (a) permitting a user to enter, via a user-interface system, an adjustable two-dimensional reference shape into which a food product is to be portioned; and (b) permitting a user to optionally edit the user-entered, adjustable two-dimensional reference shape to change the shape of the adjustable two-dimensional reference shape while displayed on an output display.", "17.The computer-readable medium according to claim 16, wherein permitting a user to optionally edit the user-entered, adjustable two-dimensional reference shape by a technique selected from the group consisting of: (a) selecting one or more locations along an outline of the two-dimensional reference shape shown on the output display and using the user-interface system to move the one or more specified locations to a new location on the output display, thereby to edit the shape of the adjustable two-dimensional reference shape; and (b) selecting one or more locations along the outline of the adjustable two-dimensional reference shape shown on the output display and using the user-interface system to specify new locations for the one or more selected locations thereby to edit the shape of the adjustable two-dimensional reference shape while shown on the output display.", "18.The computer-readable medium of claim 16, wherein step (a) comprises scanning in the adjustable two-dimensional reference shape using a scanner system.", "19.The computer-readable medium of claim 16, wherein the user using the user-interface system selects a two-dimensional reference shape from a library of reference shapes.", "20.The computer-readable medium of claim 16, wherein step (a) comprises using the user-interface system to draw an outline of the adjustable two-dimensional reference shape.", "21.The computer-readable medium of claim 16, wherein step (a) comprises using the user-interface system, the X and Y coordinate values of locations along an outline of the adjustable two-dimensional reference shape in X-Y space.", "22.The computer-readable medium of claim 16, wherein said instructions cause the computer to scale up or down the size of the adjustable two-dimensional reference shape on a food product while maintaining the shape of the adjustable two-dimensional reference shape until a predetermined weight or weight range for the portioned food product is achieved." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Workpieces, including food products, are portioned or otherwise cut into smaller pieces by processors in accordance with customer needs.", "Also, excess fat, bone, and other foreign or undesired materials are routinely trimmed from food products.", "It is usually highly desirable to portion and/or trim the workpieces into uniform sizes, for example, for steaks to be served at restaurants or chicken fillets used in frozen dinners or in chicken burgers.", "Much of the portioning/trimming of workpieces, in particular food products, is now carried out with the use of high-speed portioning machines.", "These machines use various scanning techniques to ascertain the size and shape of the food product as it is being advanced on a moving conveyor.", "This information is analyzed with the aid of a computer to determine how to most efficiently portion the food product into optimum sizes.", "For example, a customer may desire chicken breast portions in two different weight sizes, but with no fat or with a limited amount of acceptable fat.", "The chicken breast is scanned as it moves on an infeed conveyor belt and a determination is made through the use of a computer as to how best to portion the chicken breast to the weights desired by the customer, with no or limited amount of fat, so as to use the chicken breast most effectively.", "Portioning and/or trimming of the workpiece can be carried out by various cutting devices, including high-speed liquid jet cutters (liquids may include, for example, water or liquid nitrogen) or rotary or reciprocating blades, after the food product is transferred from the infeed to a cutting conveyor.", "Once the portioning/trimming has occurred, the resulting portions are off-loaded from the cutting conveyor and placed on a take-away conveyor for further processing or, perhaps, to be placed in a storage bin.", "Portioning machines of the foregoing type are known in the art.", "Such portioning machines, or portions thereof, are disclosed in prior patents, for example, U.S. Pat.", "Nos.", "4,962,568 and 5,868,056, which are incorporated by reference herein.", "Typically, the workpieces are first carried by an infeed conveyor past a scanning station, whereat the workpieces are scanned to ascertain selected physical parameters, for example, their size and shape, and then to determine their weight, typically by utilizing an assumed density for the workpieces.", "In addition, it is possible to locate discontinuities (including voids), foreign material, and undesirable material in the workpiece, for example, bones or fat in a meat portion.", "The scanning can be carried out utilizing a variety of techniques, including a video camera to view a workpiece illuminated by one or more light sources.", "The data and information measured/gathered by the scanning devices are transmitted to a computer, typically on board the portioning apparatus, which records the location of the workpiece on the conveyor as well as the shape and other parameters of the workpiece.", "With this information, the computer determines how to optimally cut or portion the workpiece at the portioning station, and the portioning may be carried out by various types of cutting/portioning devices.", "Automatic portioning systems of food products, such as boneless chicken breasts, should be capable of cutting the products into uniform shape, weight, and other parameters as provided by their users.", "Oftentimes, the users have finished samples that exemplify the users' particular needs, such as a sample having a desired shape.", "Some conventional portioning systems use fixed forms to portion products into a specific shape.", "A form is like a cookie cutter that is used to stamp out a particular shape, and then the cut piece is trimmed to a desired thickness by various types of knives or other devices.", "The use of fixed forms is cumbersome, in that each form is usable to produce only one shape, and thus many forms are required for producing various shapes.", "Also, each form “stamps out” pieces only to a particular shape, without considering, for example, the resulting weight.", "Hand cutting is also available for portioning food products into particular shapes, but hand cutting the products into both uniform shape and uniform weight is very difficult.", "Accordingly, a need exists for an improved portioning system, which is capable of cutting workpieces to a specific shape, and of growing, shrinking, or otherwise altering the shape in order to achieve one or more additional dependently related parameters such as weight.", "Preferably, such a portioning system permits a user to readily define the particular shape, and other dependently related parameters, to which workpieces are to be portioned.", "The general problem of workpiece portioning, and in particular food workpiece portioning, is to fit acceptable or desired portions into highly variable workpieces and then cut them and at the same time utilize as much of the food workpieces as possible.", "The workpieces to be processed, including food workpieces, vary in every dimension, have random defects, and have areas of fat and cartilage that must be avoided.", "The thickness varies throughout each workpiece in addition to the average thickness varying from workpiece to workpiece.", "Processors of the workpieces, for example meat workpieces, expect the portions to be of a narrow weight range, to maximize the number of portions they can sell without dissatisfying anyone.", "Their customers expect the meat portions to be of a specific shape or close enough to it with a fairly narrow thickness range so that standardized processing can occur, such as a cooking process that will yield uniformly cooked meat.", "If the meat is to be placed in a bun, it is expected that the plan-view area of the meat portion should be compatible with the bun rather than disappearing inside or hanging over the bun excessively.", "Also, it is undesirable that large pieces of fat or cartilage or bone exist in a portion.", "Further, tears, holes, and other defects are unattractive in a portion as well.", "In addition, it is expected that the waste resulting from the portioning process is minimized.", "These issues are sought to be addressed by the methods and systems discussed below." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>According to a further aspect of the present invention, the step of simulating portioning of the workpiece according to the shape of the desired final piece(s) as a directly controlled physical characteristic and calculating the one or more resulting indirectly controlled characteristics of the one or more final pieces to be portioned is repeated for multiple combinations of the one or more directly controlled shape characteristics.", "Each such combination is rated based on how closely the combination achieves the desired one or more directly controlled shape characteristics and/or the one or more indirectly controlled characteristics.", "In this regard, one or more algorithms are used to select potentially acceptable one or more directly controlled shape characteristics until an acceptable level of one or more directly controlled shape characteristics and one or more indirectly controlled characteristics are determined.", "In another aspect of the present invention, each combination is rated according to an optimization function as applied to one or more of the one or more directly controlled shape characteristics and one or more indirectly controlled characteristics, with the optimization function rating of the one or more directly controlled shape characteristics and one or more indirectly controlled characteristics related to the deviation of the one or more directly controlled shape characteristics and one or more indirectly controlled characteristics from an ideal characteristic level or range.", "In a further aspect of the present invention, a weighting factor can be imposed on the one or more directly controlled shape characteristics as well as the one or more indirectly controlled characteristics.", "According to a still further aspect, the present invention permits a user to define a desired (reference) shape(s) into which the workpieces are to be portioned, by identifying a plurality of reference coordinates of the desired reference shape(s).", "Further, the user is allowed to edit the positions of some or all of the reference coordinates to define a refined or modified shape(s) template to be used in further processing.", "To this end, the user can interrupt the normal operation of the automatic portioning system at any time to edit the desired shape(s).", "The desired shape is stored in computer memory and subsequently used to control the downstream cutting/portioning equipment of the portioning system to cut the workpieces into the desired shape.", "Alternatively, the reference shape(s) or modified shape is automatically edited by the optimization function being used.", "Simultaneously with the editing of the reference shape or the modified shape, the optimization function is capable of moving the reference/modified shape(s) about the workpiece to achieve a best fit of the reference/modified shape(s) on the workpiece.", "The end result is achieving final pieces of desired shape and other desired directly controlled physical characteristics of the final pieces, as well as desired indirectly controlled physical characteristics of the final pieces." ], [ "FIELD OF THE INVENTION The present invention relates generally to processing workpieces such as food products, and more specifically, to portioning workpieces into pieces, while also considering the desired shape of the portioned pieces as a directly controlled characteristic.", "BACKGROUND OF THE INVENTION Workpieces, including food products, are portioned or otherwise cut into smaller pieces by processors in accordance with customer needs.", "Also, excess fat, bone, and other foreign or undesired materials are routinely trimmed from food products.", "It is usually highly desirable to portion and/or trim the workpieces into uniform sizes, for example, for steaks to be served at restaurants or chicken fillets used in frozen dinners or in chicken burgers.", "Much of the portioning/trimming of workpieces, in particular food products, is now carried out with the use of high-speed portioning machines.", "These machines use various scanning techniques to ascertain the size and shape of the food product as it is being advanced on a moving conveyor.", "This information is analyzed with the aid of a computer to determine how to most efficiently portion the food product into optimum sizes.", "For example, a customer may desire chicken breast portions in two different weight sizes, but with no fat or with a limited amount of acceptable fat.", "The chicken breast is scanned as it moves on an infeed conveyor belt and a determination is made through the use of a computer as to how best to portion the chicken breast to the weights desired by the customer, with no or limited amount of fat, so as to use the chicken breast most effectively.", "Portioning and/or trimming of the workpiece can be carried out by various cutting devices, including high-speed liquid jet cutters (liquids may include, for example, water or liquid nitrogen) or rotary or reciprocating blades, after the food product is transferred from the infeed to a cutting conveyor.", "Once the portioning/trimming has occurred, the resulting portions are off-loaded from the cutting conveyor and placed on a take-away conveyor for further processing or, perhaps, to be placed in a storage bin.", "Portioning machines of the foregoing type are known in the art.", "Such portioning machines, or portions thereof, are disclosed in prior patents, for example, U.S. Pat.", "Nos.", "4,962,568 and 5,868,056, which are incorporated by reference herein.", "Typically, the workpieces are first carried by an infeed conveyor past a scanning station, whereat the workpieces are scanned to ascertain selected physical parameters, for example, their size and shape, and then to determine their weight, typically by utilizing an assumed density for the workpieces.", "In addition, it is possible to locate discontinuities (including voids), foreign material, and undesirable material in the workpiece, for example, bones or fat in a meat portion.", "The scanning can be carried out utilizing a variety of techniques, including a video camera to view a workpiece illuminated by one or more light sources.", "The data and information measured/gathered by the scanning devices are transmitted to a computer, typically on board the portioning apparatus, which records the location of the workpiece on the conveyor as well as the shape and other parameters of the workpiece.", "With this information, the computer determines how to optimally cut or portion the workpiece at the portioning station, and the portioning may be carried out by various types of cutting/portioning devices.", "Automatic portioning systems of food products, such as boneless chicken breasts, should be capable of cutting the products into uniform shape, weight, and other parameters as provided by their users.", "Oftentimes, the users have finished samples that exemplify the users' particular needs, such as a sample having a desired shape.", "Some conventional portioning systems use fixed forms to portion products into a specific shape.", "A form is like a cookie cutter that is used to stamp out a particular shape, and then the cut piece is trimmed to a desired thickness by various types of knives or other devices.", "The use of fixed forms is cumbersome, in that each form is usable to produce only one shape, and thus many forms are required for producing various shapes.", "Also, each form “stamps out” pieces only to a particular shape, without considering, for example, the resulting weight.", "Hand cutting is also available for portioning food products into particular shapes, but hand cutting the products into both uniform shape and uniform weight is very difficult.", "Accordingly, a need exists for an improved portioning system, which is capable of cutting workpieces to a specific shape, and of growing, shrinking, or otherwise altering the shape in order to achieve one or more additional dependently related parameters such as weight.", "Preferably, such a portioning system permits a user to readily define the particular shape, and other dependently related parameters, to which workpieces are to be portioned.", "The general problem of workpiece portioning, and in particular food workpiece portioning, is to fit acceptable or desired portions into highly variable workpieces and then cut them and at the same time utilize as much of the food workpieces as possible.", "The workpieces to be processed, including food workpieces, vary in every dimension, have random defects, and have areas of fat and cartilage that must be avoided.", "The thickness varies throughout each workpiece in addition to the average thickness varying from workpiece to workpiece.", "Processors of the workpieces, for example meat workpieces, expect the portions to be of a narrow weight range, to maximize the number of portions they can sell without dissatisfying anyone.", "Their customers expect the meat portions to be of a specific shape or close enough to it with a fairly narrow thickness range so that standardized processing can occur, such as a cooking process that will yield uniformly cooked meat.", "If the meat is to be placed in a bun, it is expected that the plan-view area of the meat portion should be compatible with the bun rather than disappearing inside or hanging over the bun excessively.", "Also, it is undesirable that large pieces of fat or cartilage or bone exist in a portion.", "Further, tears, holes, and other defects are unattractive in a portion as well.", "In addition, it is expected that the waste resulting from the portioning process is minimized.", "These issues are sought to be addressed by the methods and systems discussed below.", "SUMMARY OF THE INVENTION According to a further aspect of the present invention, the step of simulating portioning of the workpiece according to the shape of the desired final piece(s) as a directly controlled physical characteristic and calculating the one or more resulting indirectly controlled characteristics of the one or more final pieces to be portioned is repeated for multiple combinations of the one or more directly controlled shape characteristics.", "Each such combination is rated based on how closely the combination achieves the desired one or more directly controlled shape characteristics and/or the one or more indirectly controlled characteristics.", "In this regard, one or more algorithms are used to select potentially acceptable one or more directly controlled shape characteristics until an acceptable level of one or more directly controlled shape characteristics and one or more indirectly controlled characteristics are determined.", "In another aspect of the present invention, each combination is rated according to an optimization function as applied to one or more of the one or more directly controlled shape characteristics and one or more indirectly controlled characteristics, with the optimization function rating of the one or more directly controlled shape characteristics and one or more indirectly controlled characteristics related to the deviation of the one or more directly controlled shape characteristics and one or more indirectly controlled characteristics from an ideal characteristic level or range.", "In a further aspect of the present invention, a weighting factor can be imposed on the one or more directly controlled shape characteristics as well as the one or more indirectly controlled characteristics.", "According to a still further aspect, the present invention permits a user to define a desired (reference) shape(s) into which the workpieces are to be portioned, by identifying a plurality of reference coordinates of the desired reference shape(s).", "Further, the user is allowed to edit the positions of some or all of the reference coordinates to define a refined or modified shape(s) template to be used in further processing.", "To this end, the user can interrupt the normal operation of the automatic portioning system at any time to edit the desired shape(s).", "The desired shape is stored in computer memory and subsequently used to control the downstream cutting/portioning equipment of the portioning system to cut the workpieces into the desired shape.", "Alternatively, the reference shape(s) or modified shape is automatically edited by the optimization function being used.", "Simultaneously with the editing of the reference shape or the modified shape, the optimization function is capable of moving the reference/modified shape(s) about the workpiece to achieve a best fit of the reference/modified shape(s) on the workpiece.", "The end result is achieving final pieces of desired shape and other desired directly controlled physical characteristics of the final pieces, as well as desired indirectly controlled physical characteristics of the final pieces.", "BRIEF DESCRIPTION OF THE DRAWINGS The foregoing aspects and many of the attendant advantages of this invention will become more readily appreciated by reference to the following detailed description, when taken in conjunction with the accompanying drawings, wherein: FIG.", "1 illustrates a system suitable for use in performing a method of the present invention; FIG.", "2 is a flow chart illustrating a routine for evaluating the effects of cutting to certain specifications on the final product characteristics, which are not directly controlled by the portioning process, prior to performing an actual cut, according to a further aspect of the present invention; FIG.", "3 is a sample simulated screen shot, displayed on a monitor of the portioning system according to one embodiment of the present invention, defining a shape cutting path in a connect-the-dots model; FIG.", "4 is a sample simulated screen shot of a shape cutting path, which has been modified from that shown in FIG.", "3, by including a notch into the shape of FIG.", "3; FIG.", "5 illustrates a method of calculating the conformance between a reference shape and actual position shape; FIG.", "6 is a screen shot of a reference shape defined by a plurality of reference coordinates and a shaping algorithm; FIG.", "7 is a flow chart illustrating a routine for evaluating the effects on indirectly controlled parameters or specifications of a workpiece based on selected directly controlled shape parameters or specifications prior to performing an actual cut, according to another aspect of the present invention; FIG.", "8 illustrates a graphical user interface that may be employed with the systems and methods of the present invention, including that illustrated in FIG.", "7; and FIGS.", "9A through 9F illustrate several of the hundreds of iterations that a cost minimization algorithm performs in a very short time span in seeking a best fit of final pieces defined by reference points on a work piece.", "DETAILED DESCRIPTION OF THE EXEMPLARY EMBODIMENTS With respect to the terminology used in the present application, for the most part, the word “parameter” is used to refer to a physical characteristic or feature such as length, width, thickness, weight or color.", "Also for the most part, the word “specification” refers to a particular parameter value or range, such as a length of between 110 and 120 mm, a weight that is no more than 30 grams, or the color blue.", "Also, in accordance with the present application, a specific instance of a parameter will have a value; the value may or may not lie within a particular specification.", "In spite of the foregoing, it is within the scope of the present application to intermingle the use of the word “parameter” with the use of the word “specification.” For example, if the word “specification” is being utilized, this word should be interpreted broadly enough to also encompass the word “parameter,” and vice-versa.", "Also, in the present application, the word “characteristic” shall be a generic term that refers to “parameter” and/or “specification.” Also, as is apparent in the present application, the term “portion” (as derived from a workpiece) has the same meaning as the terms “piece” or “final piece” or “portioned piece.” FIG.", "1 schematically illustrates a system 10 suitable for implementing one embodiment of the present invention.", "The system 10 includes a conveyor 12 for carrying a workpiece 14 or “WP” to be portioned thereon, a scanner 16 for scanning the workpiece 14, and a cutter 18 for portioning the workpiece 14 into one or more pieces.", "Although a singular conveyor 12 is shown, multiple conveyors may be used with system 10.The conveyor 12, scanner 16, and cutter 18 are coupled to, and controlled by, a processor 20.Generally, the scanner 16 scans in the workpiece 14 to produce scanning information representative of the workpiece, and forwards the scanning information to the processor 20.The processor 20 analyzes the scanning information to calculate an optimal cut path to portion the workpiece 14 into one or more desirable pieces.", "Then, the processor 20 controls the cutter 18 to portion the workpiece 14 according to the calculated cut path.", "As illustrated, the processor includes an input device 22 (keyboard, mouse, etc.)", "and an output device 24 (monitor, printer, etc.).", "Also, other processing tools or equipment 26 can be utilized in addition to, or in place of, cutter 18.Further, additional scanners 28 and 30 can be employed to scan the workpiece and/or portions cut therefrom later along the processing line.", "The present invention is directed generally to a system and method for cutting workpieces to a particular or approximate shape, while considering one or more other parameters (e.g., weight, length, width, height, etc.).", "Describing the foregoing in more detail, the scanning system may be of a variety of different types, including a video camera (as discussed above) to view a workpiece 14 illuminated by one or more light sources.", "Light from the light source is extended across the moving conveyor belt to define a sharp shadow or light stripe line.", "When no workpiece is being carried by the infeed conveyor, the shadow line/light stripe forms a straight line across the conveyor belt.", "However, when a workpiece passes across the shadow line/light stripe, the upper, irregular surface of the workpiece produces an irregular shadow line/light stripe as viewed by a video camera directed downwardly at an angle on the workpiece and the shadow line/light stripe.", "The video camera detects the displacement of the shadow line/light stripe from the position it would occupy if no workpiece were present on the conveyor belt.", "This displacement represents the thickness (height) of the workpiece.", "The width of the workpiece is determined by the width of the irregular shadow line/light stripe.", "The length of the workpiece is determined by the length of belt travel that shadow lines/light stripes are created by the workpiece.", "In this regard, an encoder 32 is integrated into the conveyor, with the encoder generating pulses at fixed distance intervals corresponding to the forward movement of the conveyor.", "In lieu of a video camera, the scanner 16 may utilize an X-ray apparatus (not shown) for determining the physical characteristics of the workpiece, including its shape, mass, and weight.", "X-rays may be passed through the object in the direction of an X-ray detector (not shown).", "Such X-rays are attenuated by the workpiece in proportion to the mass thereof.", "The X-ray detector is capable of measuring the intensity of the X-rays received thereby, after passing through the workpiece.", "This information is utilized to determine the overall shape and size of the workpiece 14, as well as the mass thereof.", "An example of such an X-ray scanning device is disclosed in U.S. Pat.", "No.", "5,585,603, incorporated by reference herein.", "The foregoing scanning systems are known in the art and, thus, are not novel per se.", "However, the use of these scanning systems in conjunction with the other aspects of the described embodiments are believed to be new.", "The data and information measured/gathered by the scanning device(s) is transmitted to the processor 20, which records the location of the workpiece 14 on the conveyor 12 as well as the shape, length, width, thickness, size, outer perimeter, area, weight (typically by using a predicted density of the workpiece) and other physical parameters/specifications of interest pertaining to the workpiece.", "Processor 20 can be used to determine and record these physical parameters/specifications with respect to the workpiece as it exists on the conveyor 12 as well as determine these physical parameters/specifications for the workpiece or for portions cut from the workpiece after further processing or after completion of processing.", "For example, if the workpiece 14 is in the form of a raw chicken breast, fish fillet, or similar workpiece, processor 20 can be used to determine the size, shape, length, width, thickness, area, outer perimeter, and weight of the workpiece, or portions thereof, after cooking, whether such cooking is by steaming, frying, baking, roasting, grilling, boiling, etc.", "As noted above, data concerning the desired workpiece, or portion parameters/specifications, as well as the effect on workpieces and/or portions of further processing, may be stored in the memory portion 34 of the processor 20.The information stored in memory can readily be selected by user via user interface 22, for example, when changing product lines.", "For instance, the user may be processing chicken breasts for a particular customer who may require specifications for the portions to be cut from the chicken breasts.", "When the order for that customer is filled, the user may switch the mode of the computer to meet the specifications of a different customer.", "The switch may be automated and triggered by a counter that keeps track of the number of product portions that have been processed, or the switch may be carried out manually to allow the user time to retool any apparatus or recalibrate the equipment.", "The system 10 can be used to process (e.g., portion) workpieces 14 according to the present disclosure.", "In this regard, the decision process in determining where to locate desired portions on a workpiece can be thought of in terms of directly controlled physical parameters (and specifications) and indirectly controlled physical parameters (and specifications).", "For example, in algebra, Y is said to be a function of X or Y=F(X).", "The directly controlled physical parameters (specifications) are the independent variables, such as “X.” The indirectly controlled physical parameters (specifications) are the dependent variables, such as “Y,” and result from the input of the directly controlled physical parameters (specifications).", "In the context of the present invention, directly controlled physical parameters (specifications) represent actions that occur when the workpiece is processed, e.g., portioned or sliced.", "Having made cuts (or simulated the cuts) of the workpiece, the resulting portions have properties that constitute the indirectly controlled physical parameters (specifications).", "In accordance with the present invention, it is possible to consider the effect of meeting (or controlling) user-specified directly controlled physical parameters (specifications) and other resulting physical parameters (specifications) that are not directly controlled, prior to cutting.", "Specifically, the present invention further offers methods that may be used when a workpiece is being processed by cutting, trimming, slicing, etc., and it is desired that the resulting cut, trimmed, sliced, or otherwise processed product has particular characteristics not directly controlled by the cutting, trimming, slicing, or other process.", "Non-limiting examples of directly controlled physical parameters and specifications include: 1.Portion specification(s): Shape of the piece or portion; Reference coordinates that define the shape of the piece or portion; Zoom range (size) of shape in one-dimension of the two-dimensional shape of the piece or portion; Zoom range (size) of shape in the other dimension of the two-dimensional shape of the piece or portion; Zoom range in two dimensions (size) simultaneously (enlarge or decrease size of shape of the piece or portion).", "2.Positioning (location) of portion to be achieved from workpiece: Cross belt (X direction) range of the shape of the piece or portion relative to some references; Down belt (Y direction) range of the shape of the piece or portion relative to some references; Angular orientation range of the shape of the piece or portion relative to some references.", "3.Number of pieces or portions to be achieved from the workpiece.", "4.Angle of water jet cutter nozzles.", "As noted above, the portioning and/or trimming and/or slicing of a workpiece can be carried out by using high-speed water jet cutters.", "While most cutting with high-speed water jet cutters is carried out with the cutters in a vertical orientation and thus disposed normally or transversely to the workpiece, it is possible to use the high-speed water jet cutters that are set at a fixed angle from vertical, or actively control the angles of the cutters from vertical.", "If the angle of the water jet cutter is actively controlled, then such angle would be one of the user-controlled parameters.", "Examples of indirectly controlled physical parameters and specifications (properties of the portions where cutting, slicing, trimming, etc., has been simulated): 1.Weight of the piece or portion.", "2.Shape conformance of the cut, trim, slice, central portion, including any natural edges.", "3.Average thickness of the piece or portion.", "4.Maximum or peak thickness of the piece or portion.", "5.Roughness or flatness, as in variability of thickness of the piece or portion.", "6.Length of the piece or portion.", "7.Width of the piece or portion.", "8.Size (length and/or width of the piece or portion).", "9.Plan-view area of the piece or portion.", "10.Amount of fat in the piece or portion.", "11.Program errors.", "12.Down-belt cutter travel required.", "13.Holes, tears, concavity, bones, cartilage, etc., in the piece or portion.", "It is to be understood that some of these examples of indirectly controlled physical parameters can also be utilized as directly controlled parameters, such as, for example, weight, size, length, and/or width.", "In many applications where a combination of two or more physical characteristics (or parameters/specifications) of the finished product are sought (e.g., shape, weight, size, length, width, etc.", "), it may be that one or more of these characteristics are directly controllable, and others are indirect results of the cutting, trimming, slicing, etc., process.", "For example, in trimming of chicken breasts, the shape and weight of the resulting trimmed piece may be directly controllable, but the thickness of the resulting piece may not be directly controlled, and thus may vary among multiple final products.", "According to a further aspect of the present invention, where one or more physical characteristics cannot be directly controlled and yet are the results of controlling the directly controllable physical characteristics, the directly controllable physical characteristics are selected so as to optimize the indirectly controlled physical characteristics.", "Specifically, in circumstances where more than one option exists for values of the directly controllable physical characteristics, and where a simulation can be performed to assess the resulting indirectly controlled physical characteristics prior to actually performing the cutting operations, then it is possible to achieve target values or ranges for all physical characteristics.", "The present invention provides a method of accomplishing this, where the indirectly controlled physical characteristics are measured and classified into one of several categories.", "FIG.", "2 is a flow chart illustrating a general process of evaluating what effects cutting a workpiece according to certain parameters/specifications will have on the cut piece's other physical characteristics, which are not directly controlled by the cutting process, to ensure that the final piece will have desirable indirectly controlled physical characteristics.", "In step 40, a user requests to cut workpieces by directly controlling certain parameters (e.g., shape, weight, position, angular orientation, number of portions to be obtained from the work product, etc.)", "so that they fall within one of multiple acceptable categories, such as by ensuring that one of multiple specification requirements DS1, DS2, .", ".", ".", "or DSn is met.", "Further, the user requests that the pieces cut to the specification requirements DS1, DS2, .", ".", ".", "or DSn need to have one or more resulting indirectly controlled characteristic(s) (e.g., thickness, weight, shape, conformance, etc.", "), IS1, IS2, .", ".", ".", "or ISn.", "Then, for each scanned workpiece (block 42), in block 44, cutting the workpiece according to one or more of the directly controlled physical specifications (DS1, DS2, .", ".", ".", "or DSn) is simulated, and the resulting indirectly controlled physical specification(s) is calculated.", "For example, cutting according to the specification DS1 (e.g., shape) is simulated, and the indirectly controlled physical specification (e.g., thickness) resulting from cutting to the specification DS1 is calculated.", "If an acceptable combination of DS1, DS2, .", ".", ".", "or DSn and IS1, IS2, .", ".", ".", "or ISn is found, then the acceptable combination may be selected as the combination according to which the subsequent cut is to be performed.", "Various methods for selecting one combination are possible.", "For example, it is possible to continue the simulation and calculation process until the first acceptable combination is found.", "Alternatively, a value function (or its negative/opposite, a cost function) may be used to rank multiple alternative solutions.", "(Value and/or cost functions are also referred to herein as optimization functions.)", "According to this variation, cutting to the multiple specification requirements (DS1, DS2, .", ".", ".", "or DSn, in this example) is simulated, and the resulting indirectly controlled physical specification(s) (e.g., thickness) are calculated for each simulation and compared to the acceptable indirectly controlled specification(s) (IS1, IS2, .", ".", ".", "or ISn).", "If multiple acceptable combinations exist, a suitable value function is used to select the most preferable combination.", "After the acceptable, optimal combination of DS1, DS2, .", ".", ".", "or DSn and IS1, IS2, .", ".", ".", "or ISn is found, then proceeding to step 46, the portioning system is used to perform an actual cut according to the selected combination of the directly controlled and indirectly controlled physical specifications.", "As a further aspect of the present invention, each of the characteristics, i.e., parameters/specifications, both direct and indirect, can potentially have an acceptable range rather than just a single acceptable value.", "It is possible to define a “cost” function that has a value of zero at the center or other location of each range of each specification, with an increasing “cost” as the simulated values of the parameters deviate from the center or other location of the specification range.", "Further, a weighting factor can be applied to the “cost” from each of the parameters.", "Finally, the “weighted costs” are combined, such as by addition, to give a “total cost.” Thus, for each combination of the directly controlled physical characteristic and resulting indirectly controlled physical characteristic, there is a single “total cost” amount associated with the simulated cutting/trimming/slicing, etc., result.", "For example, if there are two directly controlled specification requirements, DS1 and DS2, and two resulting indirectly controlled specification requirements, IS1 and IS2, and each as a weighting factor, the total cost might be calculated by the simple equation: (Weight 1*DS1)+(Weight 2*DS2)+(Weight 3*IS1)+(Weight 4*IS2).", "It is to be understood that the term “cost” as used herein refers to the negative or opposite of the word “value” discussed above.", "These terms are related in the sense that with respect to a particular specification, an increase in the “cost” corresponds to a decrease in the “value.” The cost function definition could take almost any form, including one-sided definitions where the characteristic can never be above or below a threshold, and the target (zero cost) value is something other than the middle of a range.", "An example of this exists from packaged grocery goods where it is legally required that a container not contain less than the labeled amount.", "However, it is clearly in the interest of the product producer to be as close as possible to the labeled amount.", "Examples of three cost functions that can be used include: 1.The cost increases with deviation from the range midpoint, and continues increasing for parameter values beyond the range; 2.The cost increases from a deviation from the range midpoint, with “hard” limits (for example, large step function cost increase) at the range limits; 3.There is no cost associated with values within the range, with “hard” limits at the range limits.", "The “total cost” number is used with a multi-dimensional optimization technique, such as the “Gradient Descent” minimization algorithm, to find an optimal choice of directly controlled parameters/specifications.", "Within a limited number of steps or iterations, it is possible to find the optimal solution without having to consider all of the perhaps thousands of potential combinations of directly controlled parameter values.", "Examples of non-linear algorithms similar to Gradient Descent include the Gauss-Newton method, the BFGS method, and the Levenberg-Marquardt method.", "Other algorithms or analysis methods that may be utilized in this regard include, for example, Nelder-Mead method, differential evolutions methods, genetic algorithms, and particle swarm optimization.", "Of course, in the range of interest, linear algorithms and analysis techniques can be used to arrive at an optimum choice of directly controlled physical parameters It is to be understood that in the above description of identifying optimum directly controlled and/or indirectly controlled physical parameters and specifications, a cost function analysis has been utilized.", "However, it is also to be understood that the negative or opposite concept of a value function could be utilized instead.", "In this case, a multi-dimensional maximization technique or algorithm would be utilized to arrive at optimal directly and/or indirectly controlled parameters/specifications.", "There can be dependencies between/among the parameters that can be exploited to simplify the solution methods.", "An example of this is aspect ratio, length and width, each being a parameter despite their obvious dependence.", "The user may only need to specify length and width ranges, with the aspect ratio being “worked out” in the software.", "There are instances in which particular parameters are chosen as directly controlled parameters.", "Two examples are set forth below.", "To simplify the present discussion, the examples include only one portion to be derived from a workpiece and only one parameter/specification for the portion.", "As a first example, the primary method is to start with a specified shape as a directly controlled physical parameters and zoom the shape in or out in one dimension, such as width; zoom the shape in or out in a second dimension, such as length; move the shape across the workpiece; move the shape lengthwise of the workpiece; and/or rotate the shape to various angles.", "Even though weight is one of the main physical parameters that may be targeted, this analysis allows weight to be an indirectly controlled physical parameter, which depends on various degrees of zooming and moving about the workpiece to locate an acceptable thickness for the portion.", "This is considered to be an efficient analysis method.", "An alternative methodology is to begin with a specified shape as a directly controlled physical parameter, as further directly controlled parameters utilize weight, aspect ratio (ratio of length over width), movement of the shape up and down the length of the workpiece, movement of the shape across the width of the workpiece, and/or rotation of the shape to various angles.", "In the background, in a separate algorithm, the zoom (enlargement or reduction) on the shape is adjusted, until a specified weight or weight range is achieved.", "In this alternative method, “zoom” is then an indirectly controlled physical parameter.", "The shape of the desired portion(s) is often one primary, if not the primary, directly controlled physical parameter sought to be achieved.", "In this regard, the overall shape of the workpiece can be determined, as described above, by scanning the workpiece and then using the processor 20 to analyze the data produced from the scanner 16.In this manner, it is possible to determine if the specified or reference shape of the desired portion(s) can be positioned on the workpiece and what location or locations are satisfactory in this regard.", "Moreover, a specified portion shape can be enlarged or decreased by zooming in and out in one dimension, such as width or length, or in both dimensions.", "In addition, the specified portion shape can be moved about the workpiece both laterally and lengthwise of the workpiece.", "Also, the specified or reference portion shape may be rotated about the Y-axis in an effort to better place the specified shape on the workpiece.", "In seeking to place the specified shape of the portion on the workpiece, these steps consider the reference shape in its entirety, including the entire area occupied by the reference shape, as well as the outer perimeter and contours of the reference shape.", "As will be appreciated, a significant amount of computer processing power is needed to carry out the foregoing analysis at an acceptable speed.", "Rather than considering the shape of the reference piece or portion as a whole in the foregoing analysis, an alternative is to define the portion reference shape by a few control coordinates or points located about the outer perimeter of the portion reference shape.", "FIG.", "3 provides an example of a reference shape of a portion defined by control coordinates or points using a Cartesian coordinates system.", "In this regard, the X- and Y-coordinates of 48 points about the perimeter of the workpiece WP are defined.", "These coordinates can be displayed on a screen 60 displayed on monitor 24.The shape defined by the coordinates is shown in a shape window 62 of screen 60.Each of the coordinates can be numbered, and the first coordinate could be defined as the starting point.", "The unit or scale system used in FIG.", "3 consists of millimeters.", "However, other units of measurement can be used, for example, inches.", "In addition, although the coordinate system of FIG.", "3 is illustrated in terms of a Cartesian coordinate system, any other suitable coordinate system may also be utilized, such as a Polar coordinate system.", "The reference shape of FIG.", "3, as defined by its control points or coordinates, may be stored in the memory unit 34 of processor 20.Of course, other reference shapes as defined by control points may also be stored in memory.", "As discussed herein, a plurality of shaped final pieces may be portioned from a single workpiece or section of a single workpiece.", "The user may choose to edit the control points of a reference shape during or before application of the thus modified reference shape to the workpieces to be portioned.", "This editing may be as a result of a customer change or preference in the shape of the final pieces, or perhaps may reflect the user's knowledge of the physical attributes of the current set of workpieces to be portioned.", "The reference shape can be edited in a number of different ways.", "For example, the user can utilize the “Move This Point” icon 64 on the screen 60, and select one of the points or coordinates, which will then be highlighted (see, for example, Point 7 highlighted in the example of FIG.", "3).", "The user may then utilize the arrow keys provided on a standard keyboard, or use the mouse to move the selected point in the X-Y space.", "For example, pressing the “right” arrow key once will move the point in the Plus-X direction by a certain increment; for example, 0.1 millimeter, while pressing the “up” arrow key once will move the point in the Plus-Y direction by a certain increment.", "Alternatively, referring to FIG.", "4, the user may select the X or Y value of a reference point to be edited, and then simply type in a new value directly onto the listing shown in screen 60 of FIG.", "4.For example, the user may select the X and Y values for points 20, 21, and 22 by, for example, highlighting Section 70 on the screen 60, and then directly entering new X and Y values to the listing.", "As the user enters such new values, the shape outlined in window 62 changes to correspond to the new X and Y values of these points.", "Once the editing of the reference shape has been completed to the satisfaction of the user, the user may select a “save this shape” icon 72, positioned on screen 60, to save the modified shape into memory 34.Of course, the program may allow the user to have the X and Y values automatically saved during the editing process.", "As noted above, a library of reference shapes may be stored in memory 34, and such shapes may be edited by the user.", "In addition, it is possible to create a new shape by defining the X and Y coordinates for all control points, for example, points 1-48 in FIGS.", "3 and 4.Although FIGS.", "3 and 4 illustrate a reference shape defined by 48 control points, it is to be understood that a fewer or greater number of control points may be utilized to define the reference shape.", "For example, as few as 3 points may be sufficient, depending on the shape of the desired final portion, or perhaps up to 10, 12 or even a larger number of control points may be utilized if the final shape is relatively complex.", "Of course, the greater number of control points utilized, the greater the processing capability would be needed to apply the reference shape to workpieces in a timely manner.", "Once the reference shape has been edited, certain of the control points may be accented.", "The purpose of such accented control points is to modify the edited shape, for example by moving the accent points in or out.", "Such movement of the accent points is useful to modify the edited shape to accommodate the shape of the workpiece or to achieve one or more other directly or indirectly controlled parameters, such as weight, thickness, or avoidance of undesired physical features (such as cartilage, bone, or fat) on the workpiece.", "The computer analysis system being used can move the accent points to fit the workpiece, as well as based on other criteria.", "Also, applicants have found that the use of reference coordinates to define desired shapes of the final pieces makes it possible to readily change the shape of the final pieces when fitting final pieces on a workpiece.", "Sometimes a slight adjustment in shape will tend to be a much better “fit” of the shape on the workpiece, while at the same time avoiding tears, voids, cartilage, etc., in the workpiece.", "This results in a better yield from the workpiece.", "As noted above, one of the identified indirectly controlled physical parameters or specifications is the shape conformance of the final piece to the initial reference shape; in other words, the extent to which the shape of the final piece deviates from the desired or ideal reference shape.", "This information is also employed in the optimization analysis used with a cost or value function to analyze for optimal combinations of directly or indirectly controlled physical parameters or specifications.", "For “one dimensional” parameters or characteristics, such as weight, length, width or thickness, the deviation of the parameter or characteristic from a mid-point or defined zero cost point is easily analyzed.", "But, for the shape of the desired final piece, the deviation or conformance thereof from a desired reference shape is not as simply analyzed.", "However, there are numerous techniques for analyzing such conformance or deviation.", "One such analysis may look at each of the control points of the reference shape versus the location of the corresponding control points of the proposed final shape once the reference shape has been adjusted into a modified shape and placed on the workpiece at a potential, acceptable location.", "The deviation between the control points of the reference shape and the corresponding boundary or edge of the proposed final piece can be measured.", "In this regard, in the example shown in FIG.", "5, control point number 80A is located within the boundary of the proposed final piece 78 at corresponding location 78A, and this distance deviation is noted.", "Correspondingly, control point No.", "80F is beyond the boundary of the perimeter of the proposed final piece 78 at corresponding location 78F.", "The distance that the control point 80F is exterior of proposed final piece 78 is noted.", "This analysis is carried out for all of the control points 30A-30H of the reference shape shown in FIG.", "5.Moreover, this analysis also can be carried out at other locations along the perimeter of reference shape, such as at the unnumbered locations shown in FIG.", "5.Thereafter, the mean and standard deviation that the control points vary from the corresponding location on the workpiece (potential final shape) is calculated.", "These values may be used to determine whether the reference shape being utilized is within an acceptable conformance range.", "Another example of analyzing the conformance of the reference shape on the workpiece includes calculating a Root-Mean-Square (RMS) error between each of the reference points and the corresponding points on the proposed final piece.", "In this analysis the reference shape can be considered as a whole or perhaps be divided into sections, for instance into quadrants as shown in FIG.", "5.Thereafter, for each of the reference shape quadrants, the difference in the position of the control points relative to the actual corresponding location on the proposed final piece is calculated.", "This difference can be readily calculated by using the X-Y coordinates of the position of each of the reference points as the square root of the sum of the squares of X and Y errors.", "Thereafter, the square values of these distances are summed up and the sum is divided by the number of corresponding points, and finally the square root of the quotient is taken as the RMS error value between the reference shape and the proposed final shape.", "As an alternative to the foregoing analysis method, maximum RMS error value allowable between the reference shape and a potential final shape may be selected and used to define the acceptable shape requirements.", "Thus, unlike the previous described method, in which maximum RMS value was calculated based on an actual comparison between a reference shape and a proposed final shape, in this alternative method, the maximum RMS error value may simply be selected or predetermined by the user.", "In essence, the acceptable shape requirement is being defined in terms of the percentage of the area of the final piece not conforming to the reference shape.", "In another example, the acceptable shape requirements may be defined based on a reference shape, by taking the perimeter of the reference shape as providing the mean positional values and by further selecting a standard deviation value that defines acceptable deviation from the mean positional values.", "In this example, a confidence limit may be defined in terms of the standard deviation in each of various perimeter points along the reference shape.", "The user can modify the allowable shape variation by changing the confidence limit or the number of allowable standard deviations.", "Of course, other methods of defining acceptable shape requirements based on a reference shape will be apparent to one skilled in the art.", "As discussed above, an optimization function in terms of a cost function or a value function can be used to rank multiple alternative potential final piece configurations portioned from a workpiece.", "Of course, the optimization function can be applied with respect to the use of control points in defining acceptable shapes for final pieces.", "In this regard, shape conformance can be one component in an overall optimization function.", "With respect to a cost function analysis, a cost can be associated with how far a proposed final shape deviates from a reference shape using a conformance analysis, for example, one of the methods described above.", "In the cost function, a zero value can be ascribed to the situation in which the proposed final portion shape matches the reference shape.", "As the proposed final shape deviates from the reference shape, costs can be ascribed to such deviation whether in a linear relationship or otherwise.", "Moreover, the cost function can also take into consideration whether the shape of the proposed final piece is larger than or smaller than the reference shape.", "In this regard, if it is important to have a minimum size or shape, the cost associated with a proposed final piece having a shape smaller than the reference shape can be set at a higher cost in deviating from the reference shape in terms of the final shape being larger than the reference shape.", "In essence, a weighting factor is applied for proposed final shapes that are smaller than the reference shape.", "Of course, although shape may be a directly controlled physical characteristic, indirectly controlled physical characteristics may also be of importance.", "For example, an indirectly controlled physical characteristic might be the weight of the final piece, the average thickness of the final piece, the maximum thickness of the final piece, the amount of fat in the final piece, the conformance of the shape of the final piece to the desired reference shape, etc.", "These indirectly controlled physical characteristics may also be considered in the cost analysis, and also be weighted in value, just as directly controlled physical characteristics may be weighted in value.", "As such, as discussed above, for each combination of shape as a directly controlled physical characteristic and the resulting indirectly controlled physical characteristic(s), a ‘total cost’ amount associated with the proposed final piece can be determined.", "Also, although this portion of the discussion focused on a “cost” analysis, it is to be understood that the analysis may instead be carried out in terms of a value function.", "FIG.", "6 is a further example of the present disclosure wherein a portion shape 100 is defined by six control points 101, 102, 103, 104, 105, and 106.Straight lines are used to connect the control points, resulting in an irregularly shaped hexagon.", "A curve-fitting algorithm is then utilized to interconnect the control points in a smooth reference shape.", "In the present example, the smooth reference shape lies beyond the exterior of the hexagon.", "The reference shape 100 is then applied to workpieces.", "To this end, shape conformance rules are utilized that allow for deviation from the shape 100 with a weighted cost function (or value function) associated with such deviation.", "In this regard, the coordinates of the control points can be moved relative to each other to thereby alter the reference shape.", "Also, the control points can be moved as a set about the workpiece in seeking a best fit of the modified reference shape on the workpiece.", "Driven by an optimization algorithm, the overall cost function being used is sought to be minimized as the control points are moved relative to each other, as well as as a set about the workpiece.", "In addition to seeking to minimize the cost function due to deviation of a proposed portion shape from the beginning or reference shape, as in the examples discussed above, other specifications may also be considered in the optimization algorithm, including indirectly controlled weighted physical specifications such as weight, thickness, roughness, etc.", "Thus, the optimization algorithm typically will be composed of selected directly and indirectly controlled physical characteristics.", "Generally, these will be one component and one weighting factor for each such directly controlled and indirectly controlled characteristic that composes the optimization function.", "Such components can be combined in an additive manner (e.g., weight1*component1+weight2*component2), or in some other manner that combines the algorithm components in a manner to reflect importance, value, cost, etc., of the directly and/or indirectly controlled characteristics composing the optimization algorithm.", "Moreover, various template rules may be utilized in addition to shape conformance rules.", "These template rules can pertain to one or more desired outer perimeter configurations of the portion piece.", "The template can be quite simple, for example, a desired length and width or, as another example, a length range and a width range.", "As a further example, the template can be in the shape of a bun or roll, and the proposed portion piece can be a chicken breast, a beef patty, a fish fillet, or other food product to be placed on or within the bun or roll.", "In addition, the bun can be of various shapes, for example, circular, square, oval, rectangular, etc.", "For certain types of food items, including various types of sandwiches served at fast food restaurants, it is desirable that the meat, poultry, or fish is visible, and even extend beyond the perimeter of the bun, roll, etc., so that the meat, poultry, or fish is not hidden inside the bun, roll, etc.", "On the other hand, it is not desirable if the meat, poultry, or fish extend too far beyond the perimeter of the bun, roll, etc.", "Examples of various shapes of buns and rolls are shown in U.S. Pat.", "No.", "7,949,414, incorporated herein by reference.", "The '414 patent also shows various meat, fish, poultry, etc., items placed on the buns and rolls illustrated.", "The '414 patent discusses various shape-based conformance rules that may be applied to the portioned pieces relative to coverage of the bun or roll by the portion pieces.", "Such conformance rules may be utilized with respect to reference shapes defined by selected control points in accordance with the present disclosure.", "As noted above, perhaps one of the simplest executions of the present method, the coordinates of the control points are moved about the workpiece as a set, as well as relative to each other, by an optimization algorithm in an effort to minimize the associated overall cost function being employed.", "Rather than utilizing only the movements of such control points, applicants have found that acceptable solutions can be facilitated by applying up to four additional directly controlled shape related parameters, including zooming of the shape (enlarging or reduction), rotation of the shape, and moving the shape as a whole in the x direction and/or y direction.", "While simply moving the control points directly can eventually achieve the same result as using these additional shape parameters, applicants have found that utilizing these four additional directly controlled shape parameters as a group often results in reaching an acceptable solution more quickly.", "Of course, not all four additional directly controlled shape parameters need be used.", "Rather, one or more of these additional shape parameters may be employed, such as zoom in the x direction or zoom in the y direction, rather than a single undistorted zoom in both the x and y directions simultaneously.", "Moreover, the optimization algorithm is capable of determining what new value for the reference points to try next to seek to minimize the overall cost function.", "The optimization algorithm recommends new values for each of the directly controlled physical parameters based on previous values and upon the computed value of the cost function.", "With a new set of directly controlled physical parameters recommended by the algorithm, the indirectly controlled physical parameters are calculated and then a new cost function value is calculated using the directly and indirectly controlled physical parameter values.", "This new value is used by the optimization algorithm to recommend another set of new values for each of the directly controlled parameters.", "As will be appreciated, a change in the values of the reference points results in a change in the reference shape into a modified shape, as well as perhaps a change in the location and perhaps also orientation of the modified shape on the work product.", "FIG.", "7 is a flow chart illustrating one example of a process or method for determining how to cut a workpiece based on shape of the portioned piece as defined by control points as a directly controlled physical characteristic to achieve desired one or more indirectly controlled characteristics (parameters or specifications) of the resulting portioned piece.", "Although the example pertains to cutting a workpiece, other processes may be applied to the workpiece, either in conjunction with cutting or in lieu of cutting, such as trimming the workpiece, slicing the workpiece, or performing one or more other operations on the workpiece.", "In step 120, a user requests to cut the workpieces by directly controlling the shape of the portion on the workpiece, or number of portions to be derived from the workpiece, so that the resulting portion(s) meet the desired shape criteria.", "In the process, in step 122, the user inputs the control points of the desired shape of the portioned piece as directly controlled characteristics.", "Next in step 124, the user inputs one or more resulting indirectly controlled characteristics IC1, IC2 .", ".", ".", "ICn (parameters or specifications) to be met by the portions that meet the desired shape requirement.", "Next at step 125, the user optionally identifies control points that can be accented.", "These control points can be manipulated, for example, by the processor, to modify the reference shape as needed to best fit the reference shape on the workpiece or to best achieve one or more indirectly controlled parameters.", "Next at step 126, the user inputs acceptable ranges or values for the conformance of the shape of the final pieces relative to the reference shape.", "As discussed below, this can be performed using a graphical user interface, for example, as shown in FIG.", "8.Next in step 128, acceptable values or ranges for the one or more indirectly controlled characteristics IC1, IC2 .", ".", ".", "ICn (parameters or specifications) are inputted.", "Next in step 130, a conformance function can be assigned to the directly controlled shape parameter.", "Also, optimization functions can be assigned to the one or more indirectly controlled characteristics (parameters or specifications).", "As discussed above, the conformance and optimization functions can be in the form of a cost function.", "As an example, the cost function can have a value of zero at the center of the range of each specification, with an increasing cost as the simulated value of the parameter in question deviates from the center of the specification range.", "Also, as discussed above, the cost function definition can take many other forms, including one-sided “definitions” where parameters can never be above or below a threshold value, and the target (zero cost) value is other than at the middle of a range.", "Next at step 132, a weighting factor can be assigned to one or more of the costs of a parameter, thereby to establish that some cost factors are more important or less important than other cost factors.", "Then for the scanned workpiece (block 134), in block 136, simulating the cutting of the workpiece occurs according to the directly controlled shape parameter, and the resulting indirectly controlled physical characteristics IC1, IC2 .", ".", ".", "ICn (parameters or specifications) are calculated or determined using, for example, processor 20.For example, cutting according to the shapes 108, 110, 112 and 114 shown in FIG.", "9A, positioned on workpiece 116 is simulated and the indirectly controlled physical parameter IC (e.g., weight) resulting from the cutting to the specified shapes is calculated.", "This may be carried out by seeking to minimize the “total cost” of the resulting portion using a multi-dimensional minimization technique.", "In this technique, the accent points of the reference shapes can be moved relative to the entire reference shape.", "Alternatively, or in addition, the entire reference shapes can be moved linearly, rotated, zoomed in or out in size and/or zoomed in one direction.", "In this manner, a minimum cost or an acceptable cost can be achieved, typically after a discrete number of calculation iterations.", "This eliminates the need to perform calculations for every possible reference shape variation.", "FIGS.", "9A through 9F illustrate iterations of this optimization process as controlled by the processor, wherein four final pieces 108, 110, 112 and 114 are placed on a workpiece 116 that is quite irregular in shape.", "The algorithm used in the cost minimization analysis is capable of selecting new values for some or all of the control points that define the reference shape.", "This reduces the number of analysis iterations that are needed to arrive at an acceptable solution for the shapes and placements of the reference shapes on the workpiece.", "This analysis must be carried out very quickly to meet acceptable production goals and schedules, typically well within one second.", "After an acceptable and/or optimal combination of shape and indirectly controlled physical parameters and specifications is arrived at (see FIG.", "9F), then, at step 138, the portioning system is used to perform cutting according to the selected combination for the shape(s).", "As discussed above, optimization functions (cost value functions) can be assigned to one or more of the directly controlled shape and/or indirectly controlled physical characteristics (parameters or specifications) to achieve certain desired end results, for example to obtain the highest yield from the workpiece in terms of utilization of the workpiece.", "Other end goals may include portioning the workpiece to obtain the highest value from the workpiece.", "In this regard, certain final piece shapes and sizes portioned from the workpiece may be more valuable than others.", "For example, cutting a section of the workpiece into the shape of a sandwich portion may be more valuable than cutting the same section of the workpiece into the shape of nuggets or strips.", "Another goal might be to fulfill a customer's order.", "For example, a customer may have ordered a certain number of sandwich-shaped portions, a certain number of strip-shaped portions, and a certain number of nugget-shaped portions.", "As such, the optimization functions that are applied to the directly controlled shape and/or indirectly controlled characteristics may be designed with this in mind.", "Moreover, under the present invention, it is possible to simultaneously run multiple optimization function analyses on the workpiece when seeking desired end results.", "Based on such analyses, it may be that characteristics of the most desirable of the various analyses results will be chosen, or perhaps the characteristics corresponding to the first analysis that results in an acceptable solution may be chosen as the strategy for portioning the workpiece.", "As another alternative, the characteristics that result in the larger number of end pieces of a desired shape or that provides a desired set of final pieces that meet the desired shape characteristic(s) might be chosen.", "The portioning method and system of the present disclosure also may be operated with a plurality of optimization function analyses running at the same time on the workpiece, to quickly meet the shape parameter(s) and the indirectly controlled parameters.", "For example, one analysis may be seeking to position two final portions per workpiece, and if an acceptable solution with respect to the final pieces is not achieved, then the workpiece may be analyzed for positioning one final piece on the workpiece.", "In reference to FIGS.", "9A through 9F, if an acceptable solution could not be reached to place four final pieces on the workpiece, then analysis could have been carried out seeking perhaps to locate three, or even two, final pieces on the workpiece.", "Another alternative analysis may be attempting to place two 65 gram final pieces on the workpiece or two 105 gram final portions on the workpiece.", "Perhaps the two 65 gram portions would result in a low yield (resulting in significant trim or waste), and the 105 gram portions may result in a high yield or perhaps the two 105 gram portions would not fit on the workpiece.", "Thus, different sets of specifications are being applied to the workpiece at the same time using different optimization functions.", "FIG.", "8 shows a portion of a graphical user interface (GUI) 140 that may be used in conjunction with the present invention.", "In the GUI of FIG.", "8, the column of parameters 142 extending down the left side of the GUI (weight, length, width, angle, etc.)", "are indirectly controlled parameters that contribute to the cost function.", "By repeatedly pushing the touch screen buttons, such as weight button 144, the weight value toggles through having a padlock symbol, such as 146 on button 144, no symbol on button 150, or an “X” symbol 152 on shape conformance button 154.The lack of a symbol on button 150 corresponds to the first cost function described above, the padlock symbol 146 on button 144 corresponds to the second function described above, and the “X” symbol 152 on button 154 corresponds to the conformance cost function described above.", "The columns in FIG.", "8 labeled low 156 and high 158 contain user-settable values of the minimum and maximum value per product specifications of the end products.", "The horizontal lines 166A through 166H, each with a triangular shape disposed thereon, show a short-term average value of recent settings so that the user can visualize the process of the present invention that is occurring.", "The actual values being achieved, as well as the set range for the parameters and the weighting coefficients, can be retained by the processor being utilized, for example, processor 20, and displayed to the user using a GUI on, for example, output device 24 or other display, such as a tablet (not shown).", "This data can be shown in list format or in various graphical formats that show the distribution of that data over time or over recent work products.", "Also, statistical analysis of the data can be carried out and displayed.", "Such statistical information might include, for example, mean, medium, and standard deviation values.", "Such information can be analyzed and displayed to show how well the desired parameters and specifications are being met as well as what trade-offs are taking place to arrive at the final pieces portioned from the work product.", "It will be appreciated that the foregoing information would be very valuable to have available during the portioning of work products, including if the value, range, and/or importance of one or more directly controlled and/or indirectly controlled parameters are changed.", "The rectangularly shaped sliders 168 located under the “Importance” header 170 let the user adjust the weighting coefficients in the optimization function for individual parameters.", "The system of the present invention seeks to keep the specifications within bounds, particularly for the parameters that are given the greater importance.", "However, algorithms cannot “create” input portions that do not exist given the parameters and specifications specified.", "Thus, for example, if the thickness of the workpiece is too thin throughout the entire workpiece such that within the length and width limits it is not possible to achieve the desired weight, some other solution will have to be sought.", "In the example of FIG.", "8, the Weight parameter is set to be near the center of the range (see 166A), but the Length and Width parameters (see 166B and 166C) are above the center of their ranges because the workpiece is too thin.", "The Weight value is closer to the center of the range than the Length and Width values because Weight was given a greater importance.", "The shape that is being zoomed and moved about the workpiece may be specified in terms of shape conformance.", "In FIG.", "8, specific physical parameters may be considered in portioning a workpiece.", "Not all of these parameters need be considered in each instance that workpieces are being portioned.", "Also, other sets of parameters may be used in conjunction with a portioning system or machine.", "Also, it is anticipated that the system operator will set the specification ranges in columns 156 and 158 as well as the weighting level (Importance) column 170.Moreover, these settings may be changed quite often, for example, to adjust for changes in the physical attributes or types of workpieces being processed.", "In some situations, such as end portions to be placed in a “family pack” of retail meat packages, there is little desire for close weight control of the portions.", "In such an instance, the weight setting along the “Importance line” may be moved all the way to the left, and some other parameter's importance moved up the scale (to the right).", "Another situation with a different need for weight control is when an adaptive slicer follows a portioner.", "In that situation, the portioner computer plans for having the slicer bring the weight to the correct level so that the importance of the Length and Width parameters would increase and the Weight simply needs to be greater than or equal to the desired final weight.", "The preset invention can also be utilized to optimally position or lay out a grid of nuggets on the workpiece, whether at a location on part of the workpiece or on the entire workpiece.", "In this regard, an initial nugget grid can be laid out on the workpiece approximately to the correct size to achieve the desired weight and aspect ratio or other shape criteria.", "The nuggets do not necessarily have to be rectangular in shape, but can be of other shapes, for example, square, triangular, round, etc.", "A cost function can be applied to the nuggets based on meeting the desired shape, size, weight, aspect ratio, or other criteria applied to the nuggets.", "With this cost function, the coordinates of the grid intersections of the nuggets can be varied as the independent variable, or “directly controlled parameters.” The cost function is designed to increase cost as individual nuggets of the grid are out of specification.", "The cost function can be designed to monitor both the total cost of the collection of nuggets, and the cost associated with each nugget.", "Successive optimization determinations can be made by movement of the grid pattern about the workpiece.", "After each optimization calculation, the highest cost nugget or nuggets can be identified and eliminated prior to the next optimization.", "Such highest cost nugget or nuggets will be located along the outside of the grid pattern.", "This typically would reduce the number of grid intersections and sharpen the focus on the remaining potential nuggets.", "Also, the convergence criteria for each of the optimization iterations could be relaxed somewhat to reduce the processing time for each optimization calculation.", "Once all of the nuggets in the grid are within a desired cost structure, optimization is completed, and the nuggets can be cut.", "Also, any part of the workpiece that is not to be used as nuggets can be cut in a way that is easy for either personnel or machinery to identify such trim portions of the workpiece as not being a nugget, so as to eliminate the likelihood that such trim portions will be mixed with good nuggets.", "In the foregoing methodology for optimizing the location of nuggets on a workpiece, rather than moving the entire grid pattern as a unit, the reference points of individual nuggets could be moved, thereby for each such nugget investigated, determining its aspect ratio, shape conformance and weight, and other desired specifications, either sequentially or simultaneously.", "In this technique, the nuggets of the grid pattern can vary with respect to other nuggets in size, shape, aspect ratio, weight, etc.", "While the preferred embodiments of the invention have been illustrated and described, it will be appreciated that various changes can be made therein without departing from the spirit and scope of the invention.", "In this regard, the steps of the methods described herein can be carried out in sequences other than specified.", "Also, one or more of the specified steps can be deleted or modified from that described herein.", "Also, other modifications can be made to the methods described herein." ] ]
Patent_15875974
[ [ "LOCALIZATION ARRAY POSITION IN TREATMENT ROOM COORDINATE SYSTEM", "Localization array position determination in a treatment room coordinate system is described.", "A method may include imaging, using an imaging system, a position of one or more markers integrated with a localization array in a treatment room and transforming the position of the one or more markers to a treatment room coordinate system.", "The method also includes determining the position of the localization array in the treatment room coordinate system based on the transforming." ], [ "1.A method, comprising: imaging, using an imaging system, a position of one or more markers integrated with a localization array in a treatment room; transforming the position of the one or more markers to a treatment room coordinate system; and determining the position of the localization array in the treatment room coordinate system based on the transforming.", "2.The method of claim 1, further comprising tracking the position of the one or more markers integrated with the localization array.", "3.The method of claim 1, wherein the markers are radiographically distinguishable coils of the localization array.", "4.The method of claim 1, wherein the markers are external fiducial markers integrated with the localization array.", "5.The method of claim 1, wherein the localization array is integrated with a treatment couch.", "6.The method of claim 4, wherein the localization array is an external unit separate from a treatment couch.", "7.The method of claim 1, wherein the imaging system comprises an X-ray imaging system.", "8.The method of claim 1, wherein the imaging system comprises a computed tomography system.", "9.An apparatus, comprising: a processing unit to: receive an image of a position of one or more markers integrated with a localization array in a treatment room; transform the position of the one or more markers to a treatment room coordinate system; and determine the position of the localization array in the treatment room coordinate system based on the transform.", "10.The apparatus of claim 9, further comprising: an imaging system, operatively coupled with the processing unit, to acquire the image.", "11.The apparatus of claim 10, wherein the imaging system comprises a computed tomography system.", "12.The apparatus of claim 10, wherein the imaging system comprises an X-ray imaging system.", "13.The apparatus of claim 10, wherein the processing unit is further to track the position of the one or more markers integrated with the localization array.", "14.The apparatus of claim 10, further comprising the localization array.", "15.The apparatus of claim 10, wherein the markers are radiographically distinguishable coils of the localization array.", "16.The apparatus of claim 10, further comprising a treatment couch, wherein the localization array is integrated with a treatment couch.", "17.A non-transitory computer readable medium having instructions that when executed cause a processing unit to: receive an image of a position of one or more markers integrated with a localization array in a treatment room; transform the position of the one or more markers to a treatment room coordinate system; and determine the position of the localization array in the treatment room coordinate system based on the transform.", "18.The non-transitory computer readable medium of claim 17, wherein the instructions that when executed cause a processing unit further to track the position of the one or more markers integrated with the localization array.", "19.The non-transitory computer readable medium of claim 17, wherein the instructions that when executed cause a processing unit further to acquire the image.", "20.The non-transitory computer readable medium of claim 17, wherein the localization array is integrated with a treatment couch." ], [ "<SOH> BACKGROUND <EOH>Radiotherapy and radiosurgery are non-invasive radiation treatment options widely used to treat patients with a variety of tumors such as brain tumor, lung tumor, and liver tumor.", "Fiducial tracking is one among a variety of conventional tracking methods utilized in performing radiation treatments.", "Electromagnetic tracking systems are used to track the positions of fiducials in near real time (e.g., 10 Hz).", "In one type of system (i.e., Calypso® 4D Localization System, available from Calypso, of Seattle, Wash.), an array of four transmitter coils spread out in space induces a resonance in a fiducial or transponder coil system.", "When the magnetic field is switched off, the transponder signal during relaxation is sensed by an array of receiver coils and used to establish the position of the transponder.", "In the Calypso 4D Localization System, the transmitter and receiver coils are embedded in an array wired to a common device, and the fiducials or transponders are wireless.", "A tracking system may provide the positions of fiducials or transponders that are implanted in a patient before acquisition of a treatment planning computed tomography (CT) scan, for example for radiation therapy.", "The fiducial positions are known relative to the transmitter coils or electromagnetic localization array.", "If the transmitter coil or array position is known in the treatment room, the fiducial positions relative to the treatment room isocenter (treatment room coordinate system origin) can be obtained.", "The fiducial positions can then be used to guide treatment, for example, by directing a radiation beam at a target tracked by reference to the fiducial positions.", "In such a tracking system, inappropriate placement of the localization array may cause problems such as susceptibility to interference in the array or physical obstruction of other elements of the treatment system.", "Another problem with electromagnetic tracking systems is that the accuracy of the position and orientation information is affected by changes in the magnetic field other than those created by the transmitter coils.", "Perturbations in the magnetic field can be caused by the presence of metal (for example, in radiation therapy, a gantry or robotic manipulator and a linear accelerator) or other conductive material (for example, a treatment table top made out of conductive material).", "Thus the position information reported by an electromagnetic tracking system in practical use, for example, tracking a target region inside a patient during radiation therapy, can have a higher error than a system specification determined in a carefully controlled laboratory setting." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>The present invention is illustrated by way of example, and not by way of limitation, in the figures of the accompanying drawings.", "FIG.", "1 illustrates a treatment delivery system including localization array for tracking implanted fiducials according to one embodiment of the invention.", "FIG.", "2 illustrates a localization array integrated within a treatment couch according to one embodiment of the invention.", "FIG.", "3A illustrates a localization array mounted underneath a treatment couch using a motorized attachment mechanism according to one embodiment of the invention.", "FIG.", "3B illustrates a localization array mounted underneath a treatment couch using a motorized attachment mechanism according to one embodiment of the invention where the localization array is positioned beyond an imaging field of an imaging device.", "FIG.", "3C illustrates a localization array mounted underneath a treatment couch using a motorized attachment mechanism according to one embodiment of the invention where the localization array is rotated beyond an imaging field of an imaging device.", "FIG.", "4 illustrates a localization array attached to a treatment couch by an attachment mechanism according to one embodiment of the invention.", "FIG.", "5 is a flow chart illustrating a process for using a localization array and treatment couch assembly according to one embodiment of the invention.", "FIG.", "6 illustrates one embodiment of a treatment delivery system with an electromagnetic tracking system capable of compensating for positional information error.", "FIG.", "7 illustrates one embodiment of a localization array with embedded fiducial markers.", "FIG.", "8 illustrates one embodiment of a treatment delivery system with an electromagnetic tracking system capable of compensating for positional information error.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "REFERENCE TO RELATED APPLICATIONS This application is a divisional of U.S. patent application Ser.", "No.", "12/214,771, which claims the benefit of U.S.", "Provisional Patent Application No.", "60/936,388, which are hereby incorporated by reference.", "TECHNICAL FIELD Embodiments of the present invention relate to the field of radiation treatment, and in particular, to the positioning of an electromagnetic localization array for use in image guided radiation treatment utilizing wireless transponders.", "BACKGROUND Radiotherapy and radiosurgery are non-invasive radiation treatment options widely used to treat patients with a variety of tumors such as brain tumor, lung tumor, and liver tumor.", "Fiducial tracking is one among a variety of conventional tracking methods utilized in performing radiation treatments.", "Electromagnetic tracking systems are used to track the positions of fiducials in near real time (e.g., 10 Hz).", "In one type of system (i.e., Calypso® 4D Localization System, available from Calypso, of Seattle, Wash.), an array of four transmitter coils spread out in space induces a resonance in a fiducial or transponder coil system.", "When the magnetic field is switched off, the transponder signal during relaxation is sensed by an array of receiver coils and used to establish the position of the transponder.", "In the Calypso 4D Localization System, the transmitter and receiver coils are embedded in an array wired to a common device, and the fiducials or transponders are wireless.", "A tracking system may provide the positions of fiducials or transponders that are implanted in a patient before acquisition of a treatment planning computed tomography (CT) scan, for example for radiation therapy.", "The fiducial positions are known relative to the transmitter coils or electromagnetic localization array.", "If the transmitter coil or array position is known in the treatment room, the fiducial positions relative to the treatment room isocenter (treatment room coordinate system origin) can be obtained.", "The fiducial positions can then be used to guide treatment, for example, by directing a radiation beam at a target tracked by reference to the fiducial positions.", "In such a tracking system, inappropriate placement of the localization array may cause problems such as susceptibility to interference in the array or physical obstruction of other elements of the treatment system.", "Another problem with electromagnetic tracking systems is that the accuracy of the position and orientation information is affected by changes in the magnetic field other than those created by the transmitter coils.", "Perturbations in the magnetic field can be caused by the presence of metal (for example, in radiation therapy, a gantry or robotic manipulator and a linear accelerator) or other conductive material (for example, a treatment table top made out of conductive material).", "Thus the position information reported by an electromagnetic tracking system in practical use, for example, tracking a target region inside a patient during radiation therapy, can have a higher error than a system specification determined in a carefully controlled laboratory setting.", "BRIEF DESCRIPTION OF THE DRAWINGS The present invention is illustrated by way of example, and not by way of limitation, in the figures of the accompanying drawings.", "FIG.", "1 illustrates a treatment delivery system including localization array for tracking implanted fiducials according to one embodiment of the invention.", "FIG.", "2 illustrates a localization array integrated within a treatment couch according to one embodiment of the invention.", "FIG.", "3A illustrates a localization array mounted underneath a treatment couch using a motorized attachment mechanism according to one embodiment of the invention.", "FIG.", "3B illustrates a localization array mounted underneath a treatment couch using a motorized attachment mechanism according to one embodiment of the invention where the localization array is positioned beyond an imaging field of an imaging device.", "FIG.", "3C illustrates a localization array mounted underneath a treatment couch using a motorized attachment mechanism according to one embodiment of the invention where the localization array is rotated beyond an imaging field of an imaging device.", "FIG.", "4 illustrates a localization array attached to a treatment couch by an attachment mechanism according to one embodiment of the invention.", "FIG.", "5 is a flow chart illustrating a process for using a localization array and treatment couch assembly according to one embodiment of the invention.", "FIG.", "6 illustrates one embodiment of a treatment delivery system with an electromagnetic tracking system capable of compensating for positional information error.", "FIG.", "7 illustrates one embodiment of a localization array with embedded fiducial markers.", "FIG.", "8 illustrates one embodiment of a treatment delivery system with an electromagnetic tracking system capable of compensating for positional information error.", "DETAILED DESCRIPTION Described herein is a method and apparatus for positioning a localization array for use in image guided radiation treatment utilizing wireless transponders.", "The following description sets forth numerous specific details such as examples of specific systems, components, methods, and so forth, in order to provide a good understanding of several embodiments of the present invention.", "It will be apparent to one skilled in the art, however, that at least some embodiments of the present invention may be practiced without these specific details.", "In other instances, well-known components or methods are not described in detail or are presented in simple block diagram format in order to avoid unnecessarily obscuring the present invention.", "Thus, the specific details set forth are merely exemplary.", "Particular implementations may vary from these exemplary details and still be contemplated to be within the spirit and scope of the present invention.", "According to one embodiment of the present invention, a localization array to be used for tracking fiducial markers may be coupled with a treatment couch.", "For example, the localization array may be contained within or attached underneath or above the treatment couch.", "Such an arrangement may ensure that the localization array maintains its position with respect to the treatment couch, even if the treatment couch moves.", "Thus, the position of the localization array in the treatment room can be tracked with reference to the treatment couch, rather than tracked independently.", "Attachment of the localization array to the treatment couch may also eliminate the need for additional equipment or structures for supporting the array.", "The presence of such equipment or structures in the treatment room may block imaging equipment, such as an x-ray imager, or may physically obstruct moving equipment, such as a robotic arm for positioning a linear accelerator (LINAC).", "Accordingly, attachment of the localization array to the treatment couch may also reduce the likelihood of collisions between these pieces of equipment.", "Many approaches may be used to couple a localization array to a treatment couch at a desired position.", "For example, in one embodiment, the localization array may be contained within the treatment couch.", "In other embodiments, the localization array may be mounted underneath or above the treatment couch.", "Alternatively, the localization array may also be laid on top of the treatment couch.", "In this case, a patient undergoing radiation treatment may then lie on top of the localization array.", "A pad or other covering may be used to separate the patient and the localization array.", "The localization array may further be coupled to the treatment couch using an attachment mechanism that allows the localization array to be repositioned while remaining attached to the treatment couch.", "In other embodiments, the attachment mechanism may also allow the localization array to be detached from the treatment couch entirely and then reattached to the treatment couch at a different location.", "FIG.", "1 illustrates a radiation treatment delivery system including a localization array for tracking fiducial markers implanted in a patient's body, according to one embodiment of the invention.", "Treatment delivery system 100 includes robotic arm 101, linear accelerator (LINAC) 102, treatment couch 104 for supporting patient 103, localization array 105 for detection position of implanted fiducial markers 106, and processing unit 107.Robotic arm 101 carries a LINAC 102 that is capable of producing a beam suitable for use in radiation treatment.", "Robotic arm 101 is capable of maintaining the direction of the beam of LINAC 102 at a desired target, for example, a tumor within the body of patient 103.Robotic arm 101 may also respond to signals from a target tracking system, such as processing unit 107, to compensate for movement of the target during the treatment process.", "Treatment couch 104 may be used to support the body of patient 103 during the treatment process and may be a robotic treatment couch.", "For example, the treatment couch 104 may be a robotic couch capable of movement with at least five degrees of freedom.", "Alternatively, the treatment couch may be a robotic couch capable of movement with less than five degrees of freedom (e.g., four, three, or fewer degrees of freedom).", "In an embodiment where the treatment couch can be repositioned using a robotic arm, the position of the treatment couch in the treatment room can be determined using mechanical encoders such as sensors attached to the robot arm.", "The sensors may determine the position of the treatment couch and the localization array attached to the couch based on the joint orientations of the robotic arm.", "The treatment couch 104 may also respond to signals from a target tracking system to help compensate for movement of the target.", "Alternatively, treatment couch 104 may be another type of treatment couch, such as the Axum® treatment couch developed by Accuray, Inc. of Calif. Alternatively, other types of treatment tables may be used.", "According to one embodiment of the invention, a localization array 105 may be attached to the treatment couch 104.For example, localization array 105 may be attached to the underside of treatment couch 104 so that the detection field, a volume within which fiducial tracking is most effective, of localization array 105 is directed upwards through the treatment couch 104 and the body of patient 103.The localization array 105 may be placed so that its detection field encompasses implanted fiducial markers 106, which are implanted within the body of patient 103.The localization array can then be used to track the movement of implanted fiducial markers 106, and may include transmitter coils, receiver coils, or both transmitter and receiver coils for this purpose.", "Alternatively, transmitter coils may be removed from localization array 105, so long as the signal from the transmitter coils can still reach the implanted fiducial markers 106.Processing unit 107 may be used to collect tracking data from localization array 105 and direct robotic arm 101 to reposition the beam of LINAC 102 according to the most recently determined target position.", "The position of the target may, for example, be determined in reference to the implanted fiducials 106 if the target has a known location with respect to the implanted fiducials 106.FIG.", "2 illustrates a treatment couch assembly including an integrated localization array according to one embodiment of the invention.", "Treatment couch assembly 200 includes localization array 201, which is contained within treatment couch 202.Localization array 201 contains electromagnetic coils 203 which may be used for tracking of fiducial markers located within detection field 204.Electromagnetic coils 203 may include transmitter coils, receiver coils, or a combination of transmitter and receiver coils.", "In FIG.", "2, localization array 201 is exposed for clarity, although in some embodiments, localization array 201 may be concealed beneath the surface of treatment couch 202.Alternatively, localization array 201 may also be laid on top of treatment couch 202 and may or may not be secured to treatment couch 202.Whether laid on top or integrated within treatment couch 202, localization array 201 may be covered.", "For example, localization array 201 may be covered to protect from physical damage or for aesthetic reasons.", "The covering material may be chosen to have minimal effect on the fiducial tracking capability of the localization array 201.The covering material may also be chosen for the comfort of a patient 103 or to protect the patient 103 or the localization array 201.For example, the covering may be a pad placed over the localization array 201.Localization array 201 may also be centered with respect to treatment couch 202 along one or more axes of treatment couch 202.For example, localization array 201 may be centered along the width of treatment couch 202.Localization array 201 may, in one embodiment, cover or underlie only a portion of the surface of treatment couch 202.Alternatively, localization array 201 may cover or underlie the entire surface of treatment couch 202.While in one embodiment, treatment couch 202 contains only one localization array 201, other embodiments of treatment couch 202 may contain more than one localization array 201.During a treatment session, a patient 103 may lie on treatment couch 202 so that implanted fiducial markers 106 implanted in the body of patient 103 are within the detection field 204 of localization array 201.Localization array 201 may then be used to track the locations of implanted fiducials 106.FIG.", "3A illustrates a treatment couch assembly that includes a localization array mounted underneath the surface of a treatment couch according to one embodiment of the invention.", "Treatment couch assembly 300 includes a localization array 301 mounted underneath a treatment couch 302.Localization array 301 may be attached to a positioning mechanism 303 through an extension arm 304.Positioning mechanism 303 may be mounted on a platform 305 attached to treatment couch 302.Localization array 301 may be positioned underneath the surface of treatment couch 302 so that the detection field of localization array 301 extends through and above the surface of treatment couch 302.Localization array 301 may include transmitter coils, receiver coils, or both transmitter and receiver coils.", "Localization array 301 may also be attached to a positioning mechanism 303.In one embodiment, positioning mechanism 303 may be mounted on platform 305.Alternatively, positioning mechanism 303 may be mounted on the underside of treatment couch 302.Platform 305 may be rigidly attached to treatment couch 302 so that positioning mechanism 303 does not move with respect to treatment couch 302.Thus, repositioning of localization array 301 may occur solely through the operation of positioning mechanism 303.In alternative embodiments, positioning mechanism 303 may be attached to treatment couch 302 in a manner that allows movement between treatment couch 302 and positioning mechanism 303 and localization array 301.For example, treatment couch 302 may be mounted on slides that allow treatment couch 302 to move along the x-axis 310 with respect to positioning mechanism 303 and localization array 301.Positioning mechanism 303 may operate to move localization array 301 with respect to the treatment couch 302.For example, positioning mechanism 303 may move localization array 301 along the x-axis 310 or y-axis 311.Thus, during a radiation treatment session, the localization array 301 may be moved to a desired position so that its detection field may encompass fiducial markers being tracked without moving the patient or the treatment couch 302.Positioning mechanism 303 may also operate to move localization array 301 outside the imaging field of other imaging devices in the treatment room.", "For example, if an x-ray imager is in use, the localization array 301 may be moved out of the imaging field of the x-ray imager so that the localization array 301 is not captured in the x-ray image.", "Localization array 301 may also be moved for other reasons, such as to avoid obstructing moving equipment or personnel.", "Positioning mechanism 303 may also operate to move localization array 301 in the direction indicated by z-axis 312 in order to bring localization array 301 closer to or farther away from treatment couch 302.Positioning mechanism 303 may in one embodiment be implemented using an X-Y table.", "Alternatively, other mechanisms such as robots or non-motorized manual positioning mechanisms may be used.", "Positioning mechanism 303 may also accept inputs from a computer or other device in order to automate the movement of localization array 301 during a treatment session.", "Furthermore, positioning mechanism 303 may also send signals to another device to indicate the position of localization array 301.In one embodiment, mechanical encoders are used to determine the position of the localization array in the treatment room.", "For example, positioning mechanism 303 may utilize servo motors capable of indicating the rotational positions of the motors, which can then be used to calculate the position of the localization array 301.Alternatively, other methods for determining the location of localization array 310 may be used in conjunction with positioning mechanism 303, such as positioning marks or optical sensors.", "Localization array 301 may be attached to positioning mechanism 303 using an extension arm 304.Extension arm 304 may be used so that localization array 301 is kept away from positioning mechanism 303.For example, in cases where the operation or structure of positioning mechanism 303 may degrade the electromagnetic signals received by localization array 301, extension arm 304 may enable localization array 301 to be sufficiently removed from positioning mechanism 303 so that the electromagnetic signals are unaffected by positioning mechanism 303.Alternatively, localization array 301 may in other embodiments be attached to positioning mechanism 303 without using extension arm 304.FIG.", "3B illustrates a treatment couch assembly where the localization array is positioned beyond an imaging field of an imaging device according to one embodiment of the invention.", "Imaging device 306 is configured to capture images from within imaging field 307.Imaging device 306 may be a device such as an x-ray imager.", "Localization array 301 may be moved using positioning mechanism 303 so that localization array 301 is positioned beyond imaging field 307.With the localization array 301 in this position, imaging device 306 may avoid capturing localization array 301 in an image.", "For example, imaging device 306 may be used to capture images of a patient's anatomy while the patient is lying on treatment couch 302.In this case, allowing localization array 301 to remain in the imaging field may obscure the anatomical features which are the desired subject of the resulting image.", "FIG.", "3C illustrates a treatment couch assembly having a localization array that is rotated beyond an imaging field of an imaging device according to one embodiment of the invention.", "A rotational movement may also be used to position localization array 301 outside the imaging field 307 of imaging device 306.For example, positioning mechanism 303 may include a swivel connection to allow positioning mechanism 303 to swing localization array 301 out of the imaging field 307.FIG.", "4 illustrates a treatment couch assembly including a localization array that is secured to the treatment couch using an attachment mechanism.", "Treatment couch assembly 400 includes treatment couch 401 having a number of attachment points such as attachment point 402, clips 403 and 404, a number of positioning marks such as positioning mark 405, localization array 406, and slides 407 and 408.Clips 403 and 404 and slides 407 and 408 constitute an attachment mechanism for securing localization array 406 to treatment couch 401.Localization array 406 has a detection field 409.Treatment couch 401 may have a number of attachment points such as attachment point 402, where clips 403 and 404 may be attached.", "Localization array 406 may then be attached to clips 403 and 404.The attachment points may be located at evenly spaced positions on both sides of treatment couch 401.Each attachment point may also have a corresponding positioning mark such as positioning mark 405.The positioning marks may also be labeled with numbers or other symbols used to identify the attachment points.", "Identifying attachment points where clips 403 and 404 are attached may further facilitate determining the location of the localization array 406 with respect to treatment couch 401.This relative location may ultimately be used to locate fiducial markers such as implanted fiducials 106 tracked by the localization array 406 with respect to the beam of LINAC 102 during a radiation treatment session.", "In one embodiment, the position of the localization array 406 with respect to the treatment couch may be determined using mechanical encoders.", "For example, the attachment points or clips 403 and 404 may have sensors to indicate to which attachment points the localization array 406 is attached.", "Alternatively, if the position of the localization array 406 relative to the treatment couch is known, the position of the couch in the treatment room can be determined using mechanical encoders.", "For example, if the couch is movable on a track, sensors on the track can be used to identify the position of the couch on the sliders.", "The position of the localization array in the treatment room then can be determined by reference to the position of the treatment couch.", "The clips 403 and 404 may be attached to the attachment points using fasteners.", "For example, hooks or screw-type fasteners may be used to attach clips 403 and 404 to the attachment points.", "Other types of fasteners may also be used.", "The fasteners may be selected based on their ability to support the weight of localization array 406 and clips 403 and 404.In one embodiment, clips 403 and 404 may be separate from localization array 406 such that clips 403 and 404 may be attached to treatment couch 401 independently from localization array 406.In other embodiments, clips 403 and 404 and localization array 406 may be a single assembly to be attached to treatment couch 401 in a single piece.", "Localization array 406 may be repositioned along the x-axis 310 with respect to the treatment couch 401 by detaching clips 403 and 404, and then reattaching clips 403 and 404 at different attachment points.", "Localization array 406 may also be repositioned along the z-axis 312 by exchanging clips 403 and 404 with a set of shorter or longer clips.", "Alternatively, clips 403 and 404 may be adjustable in length so that the same clips 403 and 404 may be used to adjust the position of localization array 406 along the z-axis 312.Localization array 406 may be equipped with slides 407 and 408 to support localization array 406 on clips 403 and 404 while allowing localization array 406 to be repositioned along the y-axis 311 relative to the treatment couch 401.Using these and other mechanisms known in the art, localization array 406 may be repositioned so that its detection field 409 is in an optimal position for tracking a set of fiducial markers.", "FIG.", "5 is a flow chart illustrating a process for setting up and using an electromagnetic localization array and treatment couch assembly according to one embodiment of the invention.", "Localization array setup process 500 begins with block 501, where an optimal position for a localization array such as localization array 105 is determined.", "In one embodiment, the optimal position for localization array 105 may be a position where the detection field of localization array 105 encompasses implanted fiducial markers 106.Alternatively, an optimal position for a localization array may be determined based on other factors or a combination of factors.", "For example, the optimal position may be determined based on a desired characteristic of a signal received by the localization array 105 from the implanted fiducials 106.The optimal position may also be chosen to avoid obstruction by the localization array 105 of imaging equipment or moving equipment such as robotic arm 101.After the optimal position for the localization array is identified in block 501, execution proceeds to block 502, where positioning marks may be used to identify an attachment location for the localization array.", "For example, in one embodiment, positioning marks such as positioning mark 405 may identify one or more attachment points such as attachment point 402 where clips 403 and 404 may be attached so that localization array 406 is positioned at the optimal position.", "In other embodiments, positioning marks may not be required to identify an attachment location because the localization array may already be attached to the treatment couch.", "For example, the localization array may be integrated into the treatment couch, such as localization array 201, or the localization array may be designed to remain attached to the treatment couch between treatment sessions.", "In these cases, localization array setup process 500 may not require block 502.Following block 502 is block 503, where the localization array may be attached to the attachment location identified in block 502.For example, clips 403 and 404 supporting localization array 406 may be attached to attachment points identified in block 502 so that the localization array 406 can be positioned at the optimal position identified in block 501.In some embodiments, localization array setup process 500 may not require block 503 because the localization array may already be attached to the treatment couch.", "From block 503, execution may proceed to block 504, where the localization array may be moved to the identified optimal position.", "At this stage, the localization array may already be attached to the treatment couch.", "Thus, moving the localization array to the optimal position identified in block 501 may entail using a positioning mechanism, such as positioning mechanism 303 or slides 407 and 408, to move the localization array along one or more axes in relation to the treatment couch.", "After the localization array has been moved to the optimal position, execution may proceed to block 505, where the localization array is maintained at the optimal position during a treatment session.", "The position of the localization array may be maintained in accord with block 505 for only a portion of the entire treatment session.", "For example, if the fiducial markers move during the treatment session, the position of the localization array may be adjusted to compensate for the movement before the end of the treatment session.", "Furthermore, the localization array needs only to be sufficiently stationary to allow tracking of fiducial markers.", "For example, processing unit 107 or another part of the tracking system may tolerate or compensate for small movements of the localization array 105.The position of the localization array may be maintained by physically immobilizing the localization array with respect to the treatment couch.", "For example, if the localization array is attached to the treatment couch through a positioning mechanism such as positioning mechanism 303, the positioning mechanism may be turned off or locked in place.", "If the localization array is equipped with slides such as slides 407 and 408, then the slides may be locked, clamped, or otherwise immobilized to prevent movement of the localization array.", "Alternatively, the localization array may maintain its position without further action.", "For example, locking or clamping of slides 407 and 408 may not be required if friction is sufficient to prevent undesired movement of localization array 406.Also, if the localization array is integrated into the treatment couch, such as localization array 201, the localization array may already be immobilized with respect to the treatment couch.", "While the localization array is being maintained in a known position, the localization array may be used to track locations of fiducial markers relative to the localization array, as provided in block 506.If the position of the localization array relative to the treatment couch and the position of the treatment couch relative to other equipment are also known, then the locations of the tracked fiducial markers relative to other equipment may be determined.", "For example, the locations of the fiducial markers may be determined relative to the location of a LINAC administering radiation treatment.", "Block 506 may also be repeated during the course of the treatment session so that the location of the fiducial markers can be periodically updated.", "Thus, maintaining the localization array in a stable position relative to the treatment couch may eliminate the need for recalculating or re-detecting the positional offset of the localization array from the treatment couch each time the locations of the fiducial markers are determined.", "Furthermore, if the localization array is attached to the treatment couch, the localization array may maintain its positional offset relative to the treatment couch even if the treatment couch is moved during the treatment session.", "Another advantage of maintaining the positional offset between the localization array and the treatment table is that the fiducial markers within the detection field of the localization array may remain within the detection field of the localization array even if the treatment couch is moved.", "For example, implanted fiducial markers 106 within patient 103 lying on treatment couch 104 may be encompassed by the detection field of localization array 105.If localization array 105 is attached to treatment couch 104, then patient 103, implanted fiducials 106, localization array 105, and the detection field of localization array 105 may all move concurrently with treatment couch 104.Thus, the detection field will continue to encompass the implanted markers 106 even if the treatment couch 104 is moved, facilitating reliable tracking of the implanted fiducials 106.By tracking the locations of fiducial markers, a treatment delivery system such as treatment delivery system 100 may then use robotic arm 101 to position LINAC 102 to deliver radiation to a target that can be located with reference to the implanted fiducials 106.FIG.", "6 illustrates one embodiment of a treatment delivery system with a localization array.", "Treatment delivery system 600 is configured to compensate for positional information error in an electromagnetic tracking system resulting from perturbations in the electromagnetic tracking system's magnetic field.", "Such distortions of the magnetic field tend to increase error in the determination of the position of implanted fiducials by the electromagnetic tracking system.", "The electromagnetic tracking system of treatment delivery system 600 may include a processing unit 107, localization array 105.In one embodiment, the bias or offset error caused by perturbations in the magnetic field may be initially compensated by calibrating or characterizing the effect of the treatment delivery system (e.g., gantry system or robot-mounted LINAC 102), which could for example be a one-time procedure involving precalibration and storage of distortion offset for one or more possible positions of a gantry or robotic arm.", "In some embodiments, electromagnetic disturbances caused by equipment can be minimized by constructing the equipment from low conductivity or non-conductive materials.", "For example, the treatment couch 104 may be constructed from Kevlar.", "As compared to other light-weight materials, such as carbon-fiber, Kevlar is less conductive and thus tends to cause less distortion in the electromagnetic field.", "Nevertheless, additional sources of magnetic field distortion may not be accounted for through material selection for the treatment couch.", "A possible additional source of error is metal implants inside a patient (e.g., hip prosthesis), for which changing the material of the treatment couch or precalibrating the system may not be feasible.", "In another embodiment, an independent fiducial localization method is used in order to compute the distortion offset.", "The positions of the implanted fiducial may obtained through use of an imaging system (e.g., X-ray, x-ray computed tomography, etc.)", "that can localize the implanted fiducials with very high accuracy (e.g., several tenths of a millimeter or better).", "The difference between the imaging acquired implanted fiducial positions and the fiducial positions determined using localization array 105 is, thus, the bias or offset of the electromagnetic tracking positions.", "An x-ray imager is discussed hereafter for ease of explanation purposes.", "It should be noted again that other imaging modalities and systems such as cone-beam CT (i.e., x-ray imaging system rotated about the patient to generate a cone-beam CT) and ultrasound may be used.", "One embodiment of an X-ray imaging system includes both an X-ray source and an X-ray detector panel.", "Treatment delivery system 600 includes X-ray sources 610 and X-ray detector panels 611.The X-ray sources 610 may be mounted angularly apart, for example, about 90 degrees apart, and aimed through the treatment target (e.g., tumor within the patient) toward the X-ray detector panels 611.Alternatively, a single large detector may be used that would be illuminated by each of the X-ray sources 610.In the single detector imaging system, the X-ray sources 610 may be positioned apart at an angle less than 90 degrees to keep both images on the single detector surface.", "The detector panels 611 may be placed below the treatment target (e.g., on the floor), on the treatment couch 104, or underneath the LINAC 102, and the X-ray sources 610 may be positioned above the treatment target (e.g., the ceiling of the treatment room), to minimize magnification of the images and, therefore, the required size of the detector panels 611.In an alternative embodiment, the positions of the X-ray sources 610 and the detector panels 611 may be reversed, e.g.", "the X-ray sources 610 below the treatment target and the detector panels 611 above the treatment target.", "In another embodiment, the detector panels 611 are arranged in a manner such that they move into position for imaging and are moved out of the way during positioning of the LINAC 102 or the treatment couch 104 or during delivery of the radiation beam from the LINAC 102.By using two X-ray imagers, which could be mounted approximately orthogonally, the 2D positions of the implanted fiducials 106 in the X-ray images can be back projected to obtain their 3D positions in the treatment room.", "The fiducial positions obtained using x-ray image localization can be known with very high accuracy (several tenths of a millimeter or better).", "The difference between the X-ray image-based fiducial positions and the fiducial positions determined using localization array 105 is thus the bias or offset of the electromagnetic tracking positions.", "In one embodiment, the electromagnetic bias or offset is calculated by processing unit 107, which may be connected to localization array 105 and X-ray detector panels 611.Thus, processing unit 107 may receive the locations of the implanted fiducials 106 as determined by the localization array 105 and as determined by X-ray imaging.", "Processing unit 107 may further use the calculated electromagnetic bias or offset in controlling robotic arm 101 to direct the beam of LINAC 102 at a treatment target.", "The electromagnetic bias often changes slowly with spatial location.", "Thus, for small motions, the offset can be used to correct the real-time electromagnetic tracking positions, as determined using the localization array 105.Since electromagnetic tracking with the localization array 105 does not involve radiation exposure to the patient, it may be used to track the positions of implanted fiducials 106 in near real time.", "The use of electromagnetic tracking to avoid the use of X-ray imaging is desirable because very frequent X-ray images of the patient may result in excessive radiation exposure to the patient.", "Any bias in the electromagnetic tracking positions can be corrected by taking occasional X-ray images to locate the implanted fiducials 106 with greater accuracy.", "The frequency of the X-ray images can be varied as necessary, for example, at every position of the treatment delivery system (e.g., gantry or LINAC 102).", "Alternatively, X-ray images may be captured periodically over time.", "New X-ray images could also be acquired whenever the electromagnetic tracking fiducials move beyond a certain threshold.", "Note that using an X-ray imaging system also requires that the treatment couch (e.g., in the form of a table or chair) be relatively radiolucent.", "In order to determine the fiducial positions relative to the treatment room coordinate system, the position of localization array 105 in the treatment room needs to be known.", "The location of the localization array 105 can be obtained, for example, by tracking the array with an optical tracking system.", "However, this requires a line of sight between the array and the optical system.", "Placing the localization array 105 under the patient 103 is desirable for many reasons.", "This placement reduces potential collision issues with the treatment delivery system (gantry system or robotic arm 101 with LINAC 102).", "Placing the localization array 105 under the patient 103 could be accomplished by placing the array 105 on the treatment couch 104 and placing a pad over the array 105.The localization array 105 could also be integrated into the treatment couch 104.The localization array 105 may be movable to accommodate different patient sizes and setup positions and different treatment target positions.", "For example, localization array 105 could be placed in a platform or housing such that it can be easily moved along the long axis of the table and possibly also along the short axis of the table.", "Placing the array 105 under the patient 103, whether on or integrated into the treatment couch 104, may require a non-optical method for obtaining the position of the array 105 in the treatment room.", "One non-optical method for tracking the position of array 105 is to use one or more (e.g., two) X-ray imagers.", "FIG.", "7 illustrates one embodiment of a localization array 700 that can be tracked using X-ray imaging.", "Localization array 700 includes fiducial markers 701 that are located outside of patient 103, and also includes electromagnetic coils 203.Localization array 700 is integrated in treatment couch 202 so that detection field 204 encompasses an area above treatment couch 202.With external fiducial markers 701 embedded in array 700, the position of array 700 can be tracked using a tracking device such as an X-ray imager.", "It should be noted that the term “external fiducial markers” is used herein to distinguish from the implanted fiducials that are internal to a patient.", "Accordingly, an external fiducial marker is one which is disposed outside of a patient's body.", "External fiducial markers 701 may be made from a radio-opaque material so that external fiducials 701 will appear in X-ray images.", "By using two X-ray imagers, which could be mounted approximately orthogonally, the 2D positions of the external fiducials 701 in the X-ray images can be back projected to obtain their 3D positions.", "The 3D positions are transformed to the treatment room coordinate system and, thus, the position of the localization array 700 in the treatment room coordinate system is determined.", "Such transformations are known in the art; accordingly, a detailed description is not provided herein.", "Alternatively, electromagnetic coils 203 in the array 700 could be used as fiducials to be tracked by a tracking device.", "If the tracking device is an X-ray imager, the coils may be uniquely distinguishable radiographically.", "For example, each of the electromagnetic coils 203 may have a unique shape so that the coil and its position can be uniquely identified in an X-ray image.", "The position of localization array 700 could be determined with other methods as well.", "In one embodiment, if the localization array 700 is integrated into the treatment couch 202 and is movable with respect to treatment couch 202, a position tracking device may include mechanical encoders which can be used to obtain the position of the localization array 700 relative to the treatment couch 202.Mechanical encoders may also be used to determine the position of treatment couch 202 in the treatment room.", "Treatment couch 202 could be a conventional treatment table, or could be a table top mounted on a robotic manipulator.", "Thus, the position of localization array 700 relative to the treatment room coordinate system and the positions of implanted fiducial markers 106 in patient 103 relative to localization array 700, as electromagnetically tracked by the localization array, can be used to determine the positions of implanted fiducials 106 relative to the treatment room coordinate system.", "In addition, bias or offset error in the electromagnetically tracked position of the implanted fiducials 106 caused by disturbances in the electromagnetic field can be corrected by using occasional X-ray images to more accurately locate the implanted fiducials 106.This method for determining the location of the implanted fiducials 106 may be used not only with localization arrays that are integrated with treatment couch 104, but also with localization arrays that are not coupled to the treatment couch 104.FIG.", "8 illustrates a treatment delivery system capable of tracking the location of fiducial markers using a localization array external to the treatment couch, in conjunction with X-ray imaging according to one embodiment of the invention.", "Treatment delivery system 800 includes electromagnetic tracking system 810 connected to localization array 811.Localization array 811 has a detection field 812 that extends downwards to encompass implanted fiducials 106.Treatment delivery system 800 also includes X-ray imagers comprising X-ray sources 610 and X-ray detector panels 611.Localization array 811 may be similar to localization array 700, having electromagnetic coils that can be used to determine the positions of implanted fiducials 106.Localization array 811 is not attached to treatment couch 104, and thus may be moved independently of treatment couch 104.In one embodiment, localization array 811 is mechanically supported by electromagnetic tracking system 810.For example, localization array 811 may be mounted on an adjustable arm 813 connected to electromagnetic tracking system 810, which allows localization array 811 to be situated above patient 103.Accordingly, localization array 811 may have a detection field 812 that extends downward to encompass implanted fiducials 106 so that localization array 811 can track the positions of implanted fiducials 106.Electromagnetic tracking system 810 that is attached to localization array 811 may be an external unit containing electronics, such as drive circuitry and sensors used during the operation of localization array 811.Electromagnetic tracking system 810 may receive fiducial positions from localization array 811, and may further be connected to processing unit 107 so that the fiducial positions can be transmitted to processing unit 107.At processing unit 107, the fiducial positions can be used to control the movement of robotic arm 101.Localization array 811 may also be affected by disturbances in the electromagnetic field, such that error is increased in the electromagnetically tracked positions of the implanted fiducials 106.X-ray imagers comprising X-ray sources 610 and X-ray detector panels 611 can be used to compensate for bias or offset caused by such electromagnetic disturbances.", "By using two X-ray imagers mounted approximately orthogonally, the 2D positions of the implanted fiducials 106 in the X-ray images can be back projected to obtain their 3D positions in the treatment room with high accuracy.", "The difference between the X-ray image-based fiducial positions and the fiducial positions determined using localization array 811 is thus the bias or offset of the electromagnetic tracking positions.", "This electromagnetic bias or offset may be calculated by processing unit 107, which receives the positions of implanted fiducials 106 as determined by the localization array 105 and the X-ray imaging system.", "The offset can then be used to correct the real-time electromagnetically tracked positions, as determined using the localization array 811.Any bias in the electromagnetically tracked positions can be corrected by taking occasional X-ray images to locate the implanted fiducials 106 with greater accuracy.", "The frequency of the X-ray images can be varied as necessary, for example, at every spatial position of the treatment delivery system (e.g., gantry or LINAC 102).", "New X-ray images could also be acquired whenever the electromagnetically tracked implanted fiducials 106 move beyond a certain positional threshold.", "The resulting corrected positions of implanted fiducials 106 can be used by processing unit 107 to control robotic arm 101.Using these positions, processing unit 107 may direct robotic arm to aim LINAC 102 so that the beam of LINAC 102 intersects a treatment target that can be located by reference to the implanted fiducials 106.Alternatively, treatment delivery system 100 may be a type of system other than a robotic arm-based system.", "For example, treatment delivery system 100 may be a gantry-based (isocentric) intensity modulated radiotherapy (IMRT) system.", "In a gantry based system, a radiation source (e.g., a LINAC) is mounted on the gantry in such a way that it rotates in a plane corresponding to an axial slice of the patient.", "Radiation is then delivered from several positions on the circular plane of rotation.", "In IMRT, the shape of the radiation beam is defined by a multi-leaf collimator that allows portions of the beam to be blocked, so that the remaining beam incident on the patient has a pre-defined shape.", "The resulting system generates arbitrarily shaped radiation beams that intersect each other at the isocenter to deliver a dose distribution to the target region.", "In IMRT planning, the optimization algorithm selects subsets of the main beam and determines the amount of time that the patient should be exposed to each subset, so that the prescribed dose constraints are best met.", "In one particular embodiment, the gantry-based system may have a gimbaled radiation source head assembly.", "It should be noted that the methods and apparatus described herein are not limited to use only with medical diagnostic imaging and treatment.", "In alternative embodiments, the methods and apparatus herein may be used in applications outside of the medical technology field, such as industrial imaging and non-destructive testing of materials.", "In such applications, for example, “treatment” may refer generally to the effectuation of an operation controlled by the treatment planning system, such as the application of a beam (e.g., radiation, acoustic, etc.)", "and “target” may refer to a non-anatomical object or area.", "Certain embodiments may be implemented as a computer program product that may include instructions stored on a computer-readable medium.", "These instructions may be used to program a general-purpose or special-purpose processor to perform the described operations.", "A computer-readable medium includes any mechanism for storing or transmitting information in a form (e.g., software, processing application) readable by a computer.", "The computer-readable medium may include, but is not limited to, magnetic storage medium (e.g., floppy diskette); optical storage medium (e.g., CD-ROM); magneto-optical storage medium; read-only memory (ROM); random-access memory (RAM); erasable programmable memory (e.g., EPROM and EEPROM); flash memory; or another type of medium suitable for storing electronic instructions.", "Additionally, some embodiments may be practiced in distributed computing environments where the computer-readable medium is stored on and/or executed by more than one computer system.", "In addition, the information transferred between computer systems may either be pulled or pushed across the communication medium connecting the computer systems.", "Although the operations of the method(s) herein are shown and described in a particular order, the order of the operations of each method may be altered so that certain operations may be performed in an inverse order or so that certain operation may be performed, at least in part, concurrently with other operations.", "In another embodiment, instructions or sub-operations of distinct operations may be in an intermittent and/or alternating manner.", "In the foregoing specification, the invention has been described with reference to specific exemplary embodiments thereof.", "It will, however, be evident that various modifications and changes may be made thereto without departing from the broader spirit and scope of the invention as set forth in the appended claims.", "The specification and drawings are, accordingly, to be regarded in an illustrative sense rather than a restrictive sense." ] ]
Patent_15875975
[ [ "INCREMENTAL LOGIN AND AUTHENTICATION TO USER PORTAL WITHOUT USERNAME/PASSWORD", "A first set of records is identified as being associated with a first asset.", "A second set of records is obtained, with the second set of records being associated with a second asset.", "A confidence score is computed based at least in part on the first set of records.", "As a result of the confidence score exceeding a threshold, an interface is caused to prompt a user associated with the first asset to confirm control of the second asset.", "In response to receiving a confirmation via the interface, a message is sent to a destination associated with the second asset.", "A response received is determined to indicate that the second asset is controlled by the user.", "The second set of records is associated additionally with the first asset.", "The interface is updated to display details about the first set of records and the second set of records." ], [ "1.A computer-implemented method, comprising: identifying that a first set of records is associated with a first asset; obtaining a second set of records, the second set of records being associated with a second asset different from the first asset; computing, based at least in part on the first set of records and the second set of records, a confidence score that indicates a likelihood that the second set of records and the first set of records are associated with a same user; causing, as a result of the confidence score exceeding a threshold, an interface to prompt a user associated with the first asset to confirm control of the second asset; sending, in response to receiving a confirmation via the interface, a message to a destination associated with the second asset; determining that a response received indicates that the second asset is controlled by the user associated with the first asset; associating the second set of records additionally with the first asset; and updating the interface to display details about the first set of records and the second set of records.", "2.The computer-implemented method of claim 1, wherein sending the message to the destination includes transmitting the message via an address associated with the second asset.", "3.The computer-implemented method of claim 1, wherein the second asset is one of a computing device or an account.", "4.The computer-implemented method of claim 1, wherein the confidence score is based at least in part on output received in response to providing, as input to a plurality of decision trees, details associated with the first set of records and the second set of records.", "5.The computer-implemented method of claim 4, wherein: the plurality of decision trees comprise a random forest; and the output is a result of votes by the plurality of decision trees of the random forest.", "6.The computer-implemented method of claim 5, further comprising, as a result of determining that the response received indicates that the second asset is controlled by the user, storing the second set of records with a set of historical records usable to train the random forest.", "7.A system, comprising: one or more processors; and memory including executable instructions that, if executed by the one or more processors, cause the system to: identify that a first set of records is associated with a first asset; obtain a second set of records, the second set of records being associated with a second asset different from the first asset; compute, based at least in part on the first set of records and the second set of records, a confidence score that indicates a likelihood that the second set of records is associated with a same user as the first set of records; as a result of the confidence score exceeding a threshold, cause an interface to prompt a user associated with the first asset to confirm control of the second asset; send, in response to receiving a confirmation via the interface, a message to a destination associated with the second asset; and as a result of a determination that a response received indicates that the second asset is controlled by the user: associate the second set of records additionally with the first asset; and update the interface to display details about the first set of records and the second set of records.", "8.The system of claim 7, wherein the executable instructions that update the interface cause the system to display details about the first set of records simultaneous with details about the second set of records.", "9.The system of claim 7, wherein the executable instructions that associate the second set of records additionally with the first asset include updating a database containing the second set of records to indicate that the second set of records is associated with the first asset in addition to the second asset.", "10.The system of claim 7, wherein: the message includes a confirmation code; and the executable instructions that includes instructions that cause the system to make the determination that the response received indicates that the second asset is controlled by the user based at least in part on the response including a match to the confirmation code.", "11.The system of claim 7, wherein: the first set of records indicates that the first asset is associated with both a first user and a second user; and the executable instructions further include instructions that cause the system to cause an interface to prompt the user to provide information usable to determine which of the first user or the second user is the user.", "12.The system of claim 7, wherein the executable instructions further cause the system to, as a result of the response received failing to indicate that the second asset is controlled by the user, disassociate the second set of records from the first set of records.", "13.The system of claim 7, wherein the executable instructions that cause the system to compute the confidence score include instructions that cause the system to compute the confidence score as a result of passing details of the first set of records and the second set of records as input to a random forest having a ground truth value corresponding to a user identity.", "14.The system of claim 13, wherein the executable instructions further cause the system to retrain the random forest from a set of historical records that includes the first set of records.", "15.The system of claim 14, wherein the executable instructions that cause the system to retrain the random forest further cause the system to, as a result of the response received failing to indicate that the second asset is controlled by the user, retrain the random forest from the set of historical records disregarding the second set of records.", "16.A non-transitory computer-readable storage medium having stored thereon executable instructions that, if executed by one or more processors of a computer system, cause the computer system to at least: identify that a first set of records is associated with a first asset; obtain a second set of records, the second set of records being associated with a second asset different from the first asset; compute, based at least in part on the first set of records, a confidence score that indicates a likelihood that the second set of records is associated with the first set of records; as a result of the confidence score exceeding a threshold, cause an interface to prompt a user associated with the first asset to confirm control of the second asset; send, in response to receiving a confirmation via the interface, a message to a destination associated with the second asset; determine that a response received indicates that the second asset is controlled by the user; associate the second set of records additionally with the first asset; and update the interface to display details about the first set of records and the second set of records.", "17.The non-transitory computer-readable storage medium of claim 16, wherein the second asset is associated with an address indicating the destination to which communications can be transmitted.", "18.The non-transitory computer-readable storage medium of claim 17, wherein: the executable instructions that send the message to the destination include instructions that cause the computer system to transmit the message to the destination via the address; and the executable instructions that cause the computer system to determine that the response indicates that the second asset is controlled by the user includes instructions that cause the computer system to determine that the response indicates the message was received at the destination.", "19.The non-transitory computer-readable storage medium of claim 16, wherein the second set of records was recorded prior to the first set of records.", "20.The non-transitory computer-readable storage medium of claim 16, wherein the executable instructions further cause the computer system to associate the first set of records additionally with the second asset." ], [ "<SOH> BACKGROUND <EOH>In order to make a purchase from an online merchant, a user is often required, or at least prompted, to create an account with the merchant.", "If the user wishes to view details about previous purchases, such as estimated delivery date, tracking numbers, date, and amount of purchase, and so on, the user is often required to login to the account using a username and password.", "However, user names and/or passwords may not be top-of-mind information; that is, user names and/or passwords may be difficult to remember, especially if the user has other accounts with other merchants or online services.", "Moreover, if the user loses or forgets either the username or password to the account, the process for regaining access to the account can be cumbersome.", "Furthermore, if the user forgets that he/she already has an account with the merchant, the user may end up creating duplicate accounts, but will only be able to access details about purchases associated with the particular account and not details of all purchases from the merchant made by the user.", "Additionally, if the user makes purchases from multiple merchants, the user must view details of the purchases separately at each of the merchants' website." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>Various embodiments in accordance with the present disclosure will be described with reference to the drawings, in which: FIG.", "1 illustrates an example of a user with two assets logging in with one of them in accordance with an embodiment; FIG.", "2 illustrates an example of an unauthorized entity denied access to an account in accordance with an embodiment; FIG.", "3 illustrates an example of shared assets in accordance with an embodiment; FIG.", "4 illustrates an example of a user who has lost access to an asset in accordance with an embodiment; FIG.", "5 illustrates an example of an invoice web page in accordance with an embodiment; FIG.", "6 illustrates an example of a confirmation message in accordance with an embodiment; FIG.", "7 is a flowchart that illustrates an example of asset verification in accordance with an embodiment; and FIG.", "8 illustrates an environment in which various embodiments can be implemented.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS REFERENCE TO RELATED APPLICATION This application is a continuation of U.S. patent application Ser.", "No.", "14/820,468, filed on Aug. 6, 2015, entitled “INCREMENTAL LOGIN AND AUTHENTICATION TO USER PORTAL WITHOUT USERNAME/PASSWORD,” which claims the benefit of U.S.", "Provisional Application No.", "62/187,620, filed on Jul.", "1, 2015, entitled “INCREMENTAL LOGIN AND AUTHENTICATION TO USER PORTAL WITHOUT USERNAME/PASSWORD,” the disclosures of which are incorporated by reference herein in their entirety.", "BACKGROUND In order to make a purchase from an online merchant, a user is often required, or at least prompted, to create an account with the merchant.", "If the user wishes to view details about previous purchases, such as estimated delivery date, tracking numbers, date, and amount of purchase, and so on, the user is often required to login to the account using a username and password.", "However, user names and/or passwords may not be top-of-mind information; that is, user names and/or passwords may be difficult to remember, especially if the user has other accounts with other merchants or online services.", "Moreover, if the user loses or forgets either the username or password to the account, the process for regaining access to the account can be cumbersome.", "Furthermore, if the user forgets that he/she already has an account with the merchant, the user may end up creating duplicate accounts, but will only be able to access details about purchases associated with the particular account and not details of all purchases from the merchant made by the user.", "Additionally, if the user makes purchases from multiple merchants, the user must view details of the purchases separately at each of the merchants' website.", "BRIEF DESCRIPTION OF THE DRAWINGS Various embodiments in accordance with the present disclosure will be described with reference to the drawings, in which: FIG.", "1 illustrates an example of a user with two assets logging in with one of them in accordance with an embodiment; FIG.", "2 illustrates an example of an unauthorized entity denied access to an account in accordance with an embodiment; FIG.", "3 illustrates an example of shared assets in accordance with an embodiment; FIG.", "4 illustrates an example of a user who has lost access to an asset in accordance with an embodiment; FIG.", "5 illustrates an example of an invoice web page in accordance with an embodiment; FIG.", "6 illustrates an example of a confirmation message in accordance with an embodiment; FIG.", "7 is a flowchart that illustrates an example of asset verification in accordance with an embodiment; and FIG.", "8 illustrates an environment in which various embodiments can be implemented.", "DETAILED DESCRIPTION In the following description, various embodiments will be described.", "For purposes of explanation, specific configurations and details are set forth in order to provide a thorough understanding of the embodiments.", "However, it will also be apparent to one skilled in the art that the embodiments may be practiced without the specific details.", "Furthermore, well-known features may be omitted or simplified in order not to obscure the embodiment being described.", "Techniques described and suggested include a system and method that receives requests from users to view details associated with a first transaction conducted by the user (e.g., a purchase of items or services from an online merchant via a browser).", "The request may be in the form of a user logging into a web interface using at least some information that corresponds to a first asset (first asset information) that is provable by the user to be under the control of the user.", "Examples of such assets may be mobile telephone or an email account, and the asset information corresponding to the asset may be a mobile telephone number or an email address.", "Information provided by the user at login may include other identifying information, such as a birthdate or a national identity number.", "Based on the first asset information provided at login, the system of the present disclosure may be able to match transactions conducted by the user using such first asset information.", "The system of the present disclosure may also be able to identify other transactions appearing to be, as determined by the system, associated with the same user but being associated with information corresponding to a second asset (second asset information), different than the first asset.", "The system of the present disclosure may request confirmation that the second asset is also under the control of the user.", "Upon receiving confirmation from the user, both the first and the second asset information may be associated with a single identity by the system of the present disclosure.", "Consequently, both assets may be effectively associated with transactions made in conjunction with either asset, and logging in using either the first asset information or second asset information will allow the user to view details about transactions associated with either asset.", "Techniques described and suggested in the present disclosure improve the field of computing, specifically the field of user authentication and security, by determining user identity and authenticity by confirming assets associated with transactions that are under the current control of the user and avoiding the use of complex passwords that may be insecurely protected or easily forgotten by users.", "Additionally, techniques described and suggested in the present disclosure improve the efficiency of computing systems by performing secure authentication without the need for managing sets of credentials.", "Moreover, techniques described and suggested in the present disclosure are necessarily rooted in computer technology in order to overcome problems specifically arising with usability of interfaces by determining an identity of the user only from a minimum amount of top-of-mind information input by the user.", "FIG.", "1 illustrates a scenario 100 of an embodiment of the present disclosure.", "Specifically, FIG.", "1 depicts a user 102 who is conducting a first transaction 108A using first asset information 106A linked to an identity 110 of the user 102 that is associated with a user account 112, and a second transaction 108B associated with second asset information 106B also linked to the identity 110.In an example of an application of the present disclosure, the user 102 may visit an online merchant to make a purchase of one or more products offered for sale by the online merchant.", "The purchasing process may involve collecting information input by the user 102 (e.g., user name, email address, telephone number, country, billing address, delivery address, etc.)", "and information intrinsic to the first transaction 108A itself (e.g., item type, item price, item quantity, payment method, etc.).", "Additional information related to the first transaction 108A may also be collected, such as Internet protocol address of the device that the user is using to conduct the purchase, geolocation data (e.g., via a global positioning system about the user device), current date, and current time.", "In embodiments of the present disclosure, when a transaction is finalized, this information may be tied to the first transaction 108A (e.g., stored in a data store in association with the first transaction 108A).", "When a user seeks to log in to view details (e.g., an invoice, tracking information, total price, payment method, etc.)", "of the first transaction 108A later, the system may prompt the user 102 authenticate him/herself by inputting identifying information corresponding to an asset of the user, such as a telephone number or an email address that was input at the time of the first transaction 108A, and/or other identifying information (such as a birthdate or national identity number).", "The identifying information is intended to confirm that the user 102 seeking to view details about the first transaction 108A is actually the same user as the user who conducted the first transaction 108A.", "Such identifying information may include information corresponding to an asset of the user (also referred to as asset information).", "In the present disclosure, the term, “asset,” may refer to an item, account, or other tangible or intangible property, having identifying asset information, that can be proven to be under the control of the user 102.For example, an asset may be a telephone, an email account, a residence, a social media account, or other asset.", "The term, “asset information,” may refer to data assigned to the specific tangible or intangible property (e.g., a device, an account, etc.)", "under the control of the user 102 that may operate as an address (or other reference information) indicating a location to which communications can be transmitted, or some other identifier usable to confirm that the asset is under the control of the user 102.For example, a telephone number may be a unique series of numbers assigned to a device owned by or under the control of the user 102.Likewise, an email address may be a unique string of characters assigned to an email mailbox owned by or under the control of the user 102.Examples of asset information may include information such as a telephone number, an email address, a residential address, a social media uniform resource locator (URL), and an OAuth token.", "In the context of the present disclosure, assets may be confirmed, using the asset information, as being under the control of the user.", "Proving “control” of the asset in this context may involve acknowledging receipt and consumption of communications directed to the asset via the asset information.", "Confirmation that the user 102 entering the identifying information is the same user as a user who conducted the first transaction 108A may be obtained through a challenge-response authentication based on the identifying information.", "For example, a message (e.g., “Reply to this message to confirm,” “Enter the following confirmation code on the website,” etc.)", "may be sent to a respective telephone number or email address (i.e., asset information), and the user 102 may follow the instructions in the message to confirm that the user 102 has control of the asset.", "Although the present disclosure frequently refers to telephone numbers and email addresses as asset information, it is contemplated that other information could be used for verification.", "For example, a residential address could be considered asset information, in which case, a letter containing a confirmation code could be sent to the address by postal mail.", "Upon receiving and opening the letter, the user could enter the confirmation code into a screen of the merchant to confirm receipt of the letter at the specified address.", "Although the present disclosure uses examples of telephone numbers and email addresses as the asset information 106A-06B, it is contemplated as within the scope of the present disclosure that other information owned by or under the control of the user 102 can be considered as an asset in this context.", "For example, an OAuth access token may also be an asset associated with a transaction.", "On the other hand, a given name, a family name, or even a combination of given name and a family name may not be considered to be an asset in the context of the present disclosure, because such names cannot be reliably and/or easily verified as belonging to the user 102 attempting to view transaction information.", "Even a national identification number, such as a Social Security number in the United States, may not be sufficient to act as an asset, because it is not easily provable as being under the control of the user 102, unlike a telephone number or an email address which may be verified as being under the control of the user 102 with little difficulty (e.g., by verifying receipt of a message sent to the respective number or address).", "Other examples of assets that may be associated with the transaction may include a residence or other building (e.g., verifiable by sending a confirmation code in a letter to a postal address), or a URL of a personal social media Internet page.", "The record matching service 104 may be a record matching service for identifying users as users associated with other transactions based on occurrences of key details associated with a current transaction, of the type described within the Appendix A of U.S.", "Provisional Application No.", "62/187,620, incorporated herein by reference, which are hereby incorporated herein by reference in their entirety.", "In this manner, the record matching service 104 is able to match users with their previous purchases without the need for cumbersome login and credential verification processes.", "For example, when the user 102 is identified by the record matching service 104 as likely to be a same user as a user associated with a second transaction 108B, based on key details associated with the first and second transactions 108A-08B, embodiments of the present disclosure may determine whether to allow the user 102 to view information about the second transaction 108B potentially associated with the user 102 (pending further confirmation).", "That is, in order to confirm that the user 102 is not simply trying to impersonate a previous user in order to obtain details about the second transaction 108B, in some embodiments, the system of the present disclosure can prompt the user 102 for proof of ownership or control of the second asset information 106B provided with the second transaction 108B.", "For example, if the system of the present disclosure determines, based on a first email address provided by the user 102, that the user 102 may also be associated with the second transaction 108B conducted using a second email address the system may send a message to the second email address requesting validation that the current user owns or is in control of the second email address.", "Upon such confirmation, the system may then link/associate both the first and second email addresses with the identity of the user 102, such that in the future the user 102 can use either address as an asset to view previous transactions associated with either address.", "In some embodiments, rather than automatically sending a message to the second email address, the user 102 may be prompted by the merchant website/interface with a message similar to, “Have you used this [alternate email address/telephone number] for a previous transaction?", "If so, click here to validate,” and, after clicking, a message may be sent to the second email address or telephone number for validation in the manner described above.", "In some embodiments, portions of the second email address or telephone number may be obfuscated as an additional security precaution.", "Note that the first and second asset need not be the same type of asset.", "For example, the user 102 may have used a telephone number as the second asset information 106 and be using an email address for the first asset information 106A, and upon confirmation, in a manner described above, that the first and second asset information 106A-06B are associated with the same user and they may be linked to the same user account.", "The system of the present disclosure may be implemented as an automated payment system provided as a service to one or more merchants, such as through a software widget embedded into the merchants' online checkout web pages.", "One advantage provided by the system of the present disclosure is that the system may be used by multiple merchants, and, in this way, the user account 112 may be linked to transactions at all participating merchants without requiring the user 102 to create/register separate accounts with each merchant.", "Another advantage provided by the system of the present disclosure is that separate transactions may be identified as being potentially associated with the same user merely from details of the first transaction 108A, and then the separate transactions may be linked to the same user account upon confirmation that they are indeed associated with the same user.", "Although it is contemplated that usernames and/or passwords may be additionally or alternatively utilized by embodiments of the present disclosure, in many embodiments, the user account 112 may be created as an account without recourse to a conventional process of establishing a shared secret (e.g., username/password) between the user and the service provider in order for the user to have administrative access to the account.", "Consequently, the user may be able to “log in,” in this sense, to the user account 112 to view the user's transaction details by confirming control of an asset (e.g., an asset associated with the first asset 106A) associated with the transaction.", "Confirming control of the asset, combined with, in some cases, any details associated with the session (e.g.", "Internet protocol address of the user device, any identifying information provided, geolocation data, etc.)", "may be used by embodiments of the present disclosure to determine, with sufficient certainty (e.g., confidence score exceeding a threshold) that the identity of the user attempting to access the user account 112 is the user authorized to access the account, that credential (e.g., username/password) verification may not be required (i.e., superfluous).", "In this way, the system of the present disclosure can avoid the complexity of managing one or more sets of credentials for each user, and improve security by avoiding the need for complex password requirements and passwords, which may be insecurely protected or easily forgotten by users.", "Furthermore, any details input by the user may simply be top-of-mind information (e.g., email address, telephone number, etc.)", "or information already associated with the transaction (e.g., items selected for purchase, payment method, etc.", "), thereby improving usability of the interface for the user.", "In some implementations, proving access to a credential may be optional.", "That is, in some embodiments, the system may determine, based at least in part on certain criteria, that the user must prove access to a certain credential (e.g., password and/or username combination, fingerprint, gesture, retina scan, voice recognition, other biometric information, etc.)", "to log in to view details of a transaction.", "In some cases, such determination may be made if the certain criteria indicates that additional security or additional assurances as to the identity of the user are warranted (e.g., user is logging in from a device having a different Internet protocol address that has been previously used by user before, user is logging in from a public network or network determined by the system to be unsecured, predetermined threshold amount of time (e.g., 30 days), etc.)", "has passed since the user last logged on, etc.).", "In some implementations, the user may be logged in via a Federated authentication system provided by a Credential Service Provider.", "In some implementations, the user may be logged automatically without having to supply credentials or other personal information, as the system may recognize the user based on obtained information, such as the user's Internet protocol address, a HyperText Transfer Protocol cookie stored on the user device, and/or other information, such as browsing history, which may identify the user to the system with a satisfactory degree of certainty (i.e., likelihood that the user is correctly identified exceeds a threshold).", "The user 102 may be an individual or some other entity authorized to conduct the first transaction 108A and view details about the first transaction 108A in accordance with permissions granted by the user account 112.Each of the first and second asset information 106A-06B may be an email address, telephone number, token, integrated circuit card identifier, or other information associated with an asset that can be confirmed as being owned by or under the control of the user 102.The first and second transactions 108A-08B may be any of a variety of transactions that may be conducted with the aid of an electronic device (e.g., personal computer, mobile phone, such as the computing device 800 of FIG.", "8).", "Examples of such transactions include purchasing one or more items or services from an online merchant/vendor, selling one or more items or services through an online marketplace, making a purchase in a physical store or marketplace using the electronic device to finalize payment, and so on.", "As an example, the first transaction 108A may be a current purchase of a topcoat and a top hat by the user 102, who used an email address as the first asset information 106A when making the purchase, and the second transaction 108B may be a previous sale of black shades and white gloves by the user, who used a mobile phone number as the second asset information 106B.", "In the scenario 100, the user 102 is in the process of conducting the first transaction 108A.", "During this process the record matching service 104 may determine that details associated with the first transaction 108A suggest that the second transaction 108B may also be associated with the user 102.Upon this determination, the record matching service 104 may send a message to the user 102 inquiring whether the user 102 also owns or is in control of the second asset.", "This message sent to the user 102 may include instructions or other information for verifying the second asset information 106B; for example, the message may be sent to the second asset and may include a temporary verification code that the user 102 can input as confirmation into a corresponding field in a user interface in communication with the record matching service 104.After the user 102 has been confirmed to be an owner of or otherwise in control of the second asset, the user 102 may be permitted by the record matching service 104 to view details about the second transaction 108B.", "Once the record matching service 104 confirms that the user 102 is the same user associated with the second transaction 108B, the record matching service may link the first and second transactions 108A-08B to the same identity (the identity 110).", "The identity 110 may be a unique identifier used to link the user 102 with the user account 112.The user account 112 may be one or more records containing data about the user 102, such as name, address, username, password, and other profile information.", "FIG.", "2 illustrates a scenario 200 of an embodiment of the present disclosure.", "Specifically, FIG.", "2 depicts an unauthorized entity attempting to access details of a second transaction 208B by performing a first transaction 208A using first asset information 206A in an attempt to impersonate a user associated with the second transaction 208B.", "The record matching service 204 may be a service such as the record matching service 104 of FIG.", "1.The unauthorized entity 214 may be a user attempting to gain access to information to which the unauthorized entity 214 has insufficient permissions to access.", "The first and second asset information 206A-06B may be information that can be readily proven to be owned by or under the control of an entity associated with a corresponding transaction, such as an email address or telephone number.", "An automobile vehicle identification number may be an example of data that is insufficient to operate as an asset in this context because, although it may be unique and assigned to a specific entity, it may not be readily proven (e.g., it does not provide a means to send/receive messages or other methods of confirmation) as being under the control of the entity associated with the transaction.", "The first transaction 208A may be a purchase or a sale or some other type of transaction that the unauthorized entity 214 is conducting in an attempt to deceive the record matching service 204 into concluding that the unauthorized entity 214 is also associated with the second transaction 208B, which, in this scenario 200, is not the case.", "The second transaction 208 may be a purchase, sale, or any other transaction previously made by a different user than the unauthorized entity 214.The second transaction 208B was made in conjunction with the second asset information 206B, which, as can be seen in FIG.", "2, is not under the control of the unauthorized entity 214.Because the unauthorized entity 214 does not have control of the second asset, the unauthorized entity 214 is forced to use a different asset, the first asset information 206A instead.", "As noted, the unauthorized entity 214 may have structured the first transaction 208A in an attempt to impersonate the user associated with the second transaction 208B.", "For example, the unauthorized entity 214 may have input the same given name, family name, and postcode as the user associated with the second transaction 208B, and may have even configured the user device to impersonate an Internet protocol address of the user associated with the second transaction 208B.", "Additionally, other transaction details of the first transaction 208A may be designed to be similar to the second transaction 208B; for example, if the unauthorized entity 214 is somehow aware that part of the second transaction 208B includes a particular game console, the first transaction 208A may include game media that is compatible with the particular game console.", "Taken as a whole, the record matching service 204 may conclude, in a manner described in Appendix A of U.S.", "Provisional Application No.", "62/187,620, incorporated herein by reference, that the unauthorized entity 214 is likely the same user as associated with the second transaction 208B.", "However, the system of the present disclosure may be configured to further confirm the identity of the unauthorized entity 214 before permitting the unauthorized entity 214 access to the details of the second transaction 208B.", "To this end, the unauthorized entity 214 may be prompted, as part of the transaction interface, to confirm whether the unauthorized entity is associated with the second asset.", "If the unauthorized entity 214 does not confirm control of the second asset, the unauthorized entity 214 will not be permitted to view details of the second transaction 208B, and furthermore, will not be linked to the identity associated with the second transaction 208B (the second identity 210B), and consequently be unable to access the second user account 212B.", "If the unauthorized entity 214 agrees to confirm control of the second asset, a confirmation message or code may be sent to the second asset that provides a way to confirm receipt of the message or code.", "However, because the unauthorized entity 214 in this scenario 200 is not in control of the second asset, the unauthorized entity 214 will not receive the confirmation message or code and consequently will not be able to confirm receipt of the message or code.", "Thus, the unauthorized entity 214 will again be thwarted and be unable to access details of the second transaction 208B or the second user account 212B.", "As a result, the unauthorized entity 214 will be viewed by the system of the present disclosure as having a separate identity than the user associated with the second transaction 208B, and the system may associate the unauthorized entity 214 with a separate identity (the first identity 210A) and account (the first account 212A), in isolation from the second identity 210B and the second user account 212B.", "FIG.", "3 illustrates a scenario 300 of an embodiment of the present disclosure.", "Specifically, FIG.", "3 depicts the scenario 300 of a first user 302A who conducts a first transaction 308A using first asset information 306A and conducts a second transaction 308B using second asset information 306B that is shared with a second user 302B.", "The second user 302B conducts a third transaction 308C using the second asset information 306B and conducts a fourth transaction 308D using third asset information 306C that is shared with a third user 302C.", "The third user 302C conducts a fifth transaction 308E using the third asset information 306C.", "One of the functions of the record matching service 304 is to match the users 302A-02C to respective user identities 310A-10C.", "The record matching service 304 may be a service such as the record matching service 104 of FIG.", "1.The asset information 306A-06C may be asset information such as telephone numbers and email addresses under the control of respective users.", "The users 302A-02C may be any of a variety of individuals who conduct transactions in a manner described within the present disclosure.", "As can be seen in the scenario 300, the first asset information 306A is only assigned to the first user 302A.", "Transactions conducted by the first user 302A using the first asset information 306A can be readily identified and confirmed by the record matching service 304 as corresponding to the first identity 310A.", "However, it can be seen that the second asset is shared by both the first user 302A and the second user 302B.", "For example, the first user 302A and the second user 302B may be a husband and a wife respectively sharing a family email address or mobile phone.", "As another example, the first asset information 306A may be a personal email address for the first user 302A; whereas the second asset information 306B may be a corporate email address shared among multiple users 302A-02B.", "The record matching service 304 has the task of determining which of the identities 310A-10B correspond to the transactions 308A-08C, and which details of which of the transactions 308A-08C to allow the users 302A-02C access to.", "As can be seen in the scenario 300, the second transaction 308B and the third transaction 308C were conducted using the same asset information (the second asset information 306B).", "However, based on details associated with each of the transactions 308B-08C, the record matching service 304 has determined that it is likely that the transactions 308B-08C are not associated with the same user.", "Therefore, the second transaction 308B has been associated with the first identity 310A and the third transaction 308C has been associated with the second user identity 310B.", "Consequently, in some embodiments, a user who attempts to log into the record matching service 304 using the second asset information 306B, may only be allowed to view transaction details associated with the second asset information 306B.", "In other embodiments, if the first user 302A logs into the record matching service 304 using the second asset information 306B and seeks to access details about the first transaction 308A, the system of the present disclosure will begin the process to confirm that the first user 302A is the user associated with the first transaction 308A by sending a confirmation message to the first asset associated with the first asset information 306A.", "Upon receiving the confirmation message, the first user 302A can confirm that the first asset associated with the first asset information 306A is under the control of the first user 302A (in one of the various ways described in the present disclosure), whereupon the system of the present disclosure can allow the first user 302A access to the details of the first transaction 308A.", "However, the second user 302B logging into the system using the second asset information 306B would be unable to access details about the first transaction 308A because the second user 302 would not be able to prove control of the first asset associated with the first asset information.", "Likewise, if the first user 302A logging into the record matching service 304 using the first asset information 306A seeks to access details of the second transaction 308B, the system of the present disclosure may send a confirmation message to the second asset.", "However, if the second asset is currently under the control of the second user 302B, confirmation may not be received by the first user 302A.", "In such a situation, in order for the second transaction 308B to be associated with the first identity 310A of the first user 302A, the first user 302A may wait until the first user has control of the second asset.", "Upon confirmation that the second transaction 308B and the second asset information 306B are associated with the first user 302A, both the first and second transactions 308A-08B may be linked to the first identity 310A.", "In some implementations, if a user logs into the record matching service 304 seeking to view details regarding the second transaction 308B, because the second transaction 308B is tied to the first identity 310A of the first user 302A and because the record matching service has a data indicating that the first user 302A is also in possession of the first asset information 306A, the record matching service may send a confirmation to the first asset information 306A in order to confirm that the user is the first user 302A associated with the second transaction 308B, and not another user (e.g., the second user 302B).", "In some embodiments, the record matching service will additionally or alternatively ask for additional identifying information from the user (e.g., national identity number, password, etc.)", "in order to confirm the identity of the user who logged in using the second asset information 306B.", "For example, if one of the users 302A-02B logs in using the second asset information 306B, before determining whether to show details of the second transaction 308B or the third transaction 308C, the system of the present disclosure may request certain information in order to determine the identity of the user, such as the national identity number.", "The system may be configured to prompt the user for types of information determined to have a high probability of distinguishing users (e.g., the first user 302A and the second user 302B) from each other, such as birthdate, middle name, name of a parent, item, or amount of a most recent previous transaction, etc.", "If the information corresponds to the first user 302A, the first user 302A will be able to access the details of the second transaction 308B, but will be unable to access details of the third transaction 308C.", "Similarly, if the information corresponds to the second user 302B, the second user 302B will be able to access details of third transaction 308C but unable to access details of the second transaction 308B.", "In the unlikely event that an asset, such as the asset associated with the second asset information 306B, is mistakenly associated with the first identity 310A of the first user 302A, in some embodiments the system allows the first user 302A to correct the mistake.", "That is, the system may present a list of assets that it believes are associated with the first user 302A, and the first user 302A may be presented with an option to disassociate any asset not belonging to the first user 302A.", "Similarly, the fourth transaction 308D and the fifth transaction 308E were conducted using the same asset information (the third asset information 306C), but the record matching service 304 has determined that they were made by separate users, the second user 302B and the third user 302C respectively.", "That is, the third asset information 306C may be shared between both users 302B-02C.", "If the second user 302B logs into the record matching service using the third asset information 306C and seeks to view details regarding the third transaction 308C made using the second asset information 306B, the system of the present disclosure may send a confirmation to the second asset to ensure that the user attempting to view details about the third transaction 308C is the second user 302B and not some other user.", "In some embodiments, during a transaction, if the system of the present disclosure is unable to match the transaction with a known user, the system may create a new user identity associated with the user.", "Thus, it is possible for the same user to have multiple user identities, and if the user logged in using an asset associated with one user identity, the user may be unable to access transactions associated with a different user identity even if the same user conducted the transaction.", "In this manner, the system of the present disclosure will err on the side of data protection.", "However, in some implementations, the system of the present disclosure may permit corrections to misidentified users.", "For example, if the second user 302B and 302C are actually the same user, the second user 302B may notify the system (e.g., through an application programming interface or remote procedure call) that details for certain transactions associated with the third asset information 306C (i.e., the fifth transaction 308E) appear to be missing when the second user 302B is logged into the system and viewing transactions.", "The system of the present disclosure may perform steps to confirm that the second user 302B is indeed the user associated with the fifth transaction 308E, and, upon successful confirmation, may merge the third identity 310C with the second user identity 310B to correct the misidentification.", "In some embodiments, an interface for the users may allow the users to correct/merge misidentified identities.", "For example, the record matching service 304 may make a determination whether a user is the same user as a previous user based on probabilities determined by votes of a random forest of the supervised model exceeding a probability threshold.", "There may be situations where some transactions were close to the probability threshold but did not exceed the probability threshold.", "In those cases, when a user logs in, the system may present the user with a list of asset information or basic details of one or more transactions that approached the probability threshold, and the system may prompt the user to confirm or deny whether the user is associated with the particular asset or transaction.", "Upon confirmation, the misidentified identities may be merged with the user identity.", "In some implementations, there may be a hierarchical relationship between users who share an asset for conducting transactions.", "For example, the second user 302B may be a parent of the first user 302A and the third user 302C.", "In these implementations, the system of the present disclosure may store information indicating that the second user 302B is also allowed to access transactions made using asset information shared by the second user 302B (e.g., the second asset information 306B and the third asset information 306C).", "In such implementations, the second user 302B may be able to view details about the second transaction 308B and the fourth transaction 308D even though the transactions were conducted by the first user 302A and the third user 302C, because the transactions 308B-08C were conducted using asset information indicated in the system as being owned by the second user 302B.", "In some embodiments, the user identities 310A-10C reflect a determination that certain transactions have the appearance of being related and being associated with a particular user, and the user identities 310A-10C may not actually be associated with any identifier or similar data.", "Consequently the user identity 310A-10C may not be stored (e.g., in a data store) within the system, but may be generated at any time or generated on the fly whenever a user logs into the system to determine transactions associated with that user.", "In some cases, the record matching service 304 may determine that it has likely misidentified users as the same user.", "For example, if the first user and a second user are twins, data collected during initial transactions by each of the users may result in a determination by the record matching service 304 that the users are a single user.", "However, after the first user and/or the second user conduct one or more subsequent transactions, the record matching service 304 may determine that the users are actually distinct users.", "In this event, upon the next login by one of the users, the system may prompt the user for confirmation that certain of the transactions are actually not associated with the user who is logged in.", "Upon this confirmation, the system may then correctly assign the transactions to separate first and second users.", "FIG.", "4 illustrates a scenario 400 of an embodiment of the present disclosure.", "Specifically, FIG.", "4 depicts a user 402 who has conducted a first transaction 408A, a second transaction 408B, and a third transaction 408C using first asset information 406A, and conducted a fourth transaction 408D using second asset information 406B.", "In the scenario, the user 402 has lost access to the first asset.", "For example, the user 402 may have changed to a different Internet service provider and lost his email mailbox at that address (the first asset information 406A) as a consequence.", "As another example, the user 402 may have obtained a new mobile phone with a new number and no longer has access to the mobile phone with the old number (the first asset information 406A).", "In such an example, the user may be unable to access the transactions 408A-08C without contacting a customer service representative with the ability to reassign the transactions 408A-08C to a new asset upon further confirmation of the identity of the user 402.However, if the fourth transaction 408D, conducted using the second asset information 406B, was conducted while the user 402 still had control of the first asset and was validated during the fourth transaction 408D, the system may automatically allow the user 402 to access any of the transactions 408A-08C, because both asset information 406B-06A were validated in a same session by the user 402 before the first asset was lost.", "In some embodiments, where the first asset ends up in the hands of an unauthorized user (e.g., stolen, hacked, sold, etc.", "), the unauthorized user would be unable to view details about (i.e., denied access to) the transactions 408A-08D unless the unauthorized user had additional identifying information about the user 402 (e.g., national identity number, password, etc.).", "That is, logging into the system of the present disclosure may require more than just possession of an asset for authentication.", "Furthermore, the user 402, upon losing the first asset, may notify customer service or other administrative entity for the record matching service 404 about the loss, and upon verification of the identity of the user 402, the second asset 406 may be blocked (i.e., denied access to).", "That is, it may no longer be considered by the system as a valid asset for login and access.", "Alternatively, in some embodiments where logging in may require only asset information and top-of-mind information, an unauthorized user, with access to the asset knowledge of top-of-mind information of the valid used, may be able to log in, but may only be able to view details about transaction associated with the asset.", "Note, in some of these embodiments, successful and/or failed attempts to access details about transactions associated with a validated asset may cause a notification to be sent to one or more other validated assets of the user.", "In this manner, should an asset fall into the hands of an unauthorized user, the valid user may be promptly notified, via the user's other assets, of unauthorized access attempts using that asset.", "In some of these embodiments, the user may be able to customize the types of notifications (e.g., successful access, unsuccessful access attempt, etc.)", "should be sent to which of the user's assets.", "FIG.", "5 illustrates an invoice interface 500 of an embodiment of the present disclosure.", "As illustrated in FIG.", "5, the invoice interface 500, the interface includes sets of details 516 corresponding to previous purchases by the user (“Mac Bethad”) that are associated with a first asset information (“m.bethad@example.org”), and a list of other assets 506 that have been determined by the system to likely be associated with the user.", "Note that the invoice interface may be a web interface, a mobile application interface, or any such interface configured for execution on a computing device such as the computing device 800 of FIG.", "8.As shown in FIG.", "5, the list of assets may be displayed in a message box 518 with at least one control 524 (e.g., “validate” button) for initiating a process for validating the asset information corresponding to the other assets.", "The message box 518 may also include at least one field 522 for entering in a confirmation code to confirm a corresponding asset.", "It is contemplated that a separate interface may be launched for inputting the confirmation code in response to triggering the at least one control 524.The other assets 506 may correspond to a telephone, an email inbox, or other asset under the control of the user.", "The set of details 516 may include invoices, and may include information such as asset information used when conducting the particular transaction, items transacted, quantity, price, total price, tracking information, and so on.", "Although FIG.", "5 illustrates an invoice interface, it is contemplated that the invoice interface 500 may be alternatively an interface for different types of transactions other than purchases and other aspects of beyond invoices.", "For example, the invoice interface 500 may be a seller's interface for a user who sells items or services through an online marketplace, and may include details on items sold to customers, inventory purchased from suppliers, contracts executed, and other such transactions.", "The set of details 516 may include content/details of transactions that are associated with a confirmed/validated asset of the user.", "In the example shown in FIG.", "5, the set of details 516 show two invoices associated with a first asset of the user, the email destination at address “m.bethad@example.org.” As an asset, such as a second asset, is confirmed as being under the control of the user, details of transactions associated with the newly-confirmed asset may be included in the set of details 516 and the invoice interface 500 may be updated to reflect/display the added details.", "In this manner, the assets for both the first (previously confirmed) asset and second (newly confirmed) may be simultaneously presented in the invoice interface 500.Note that “simultaneously presented” in this context does not necessarily indicate that content associated with both assets are concurrently or synchronously output to the interface, but rather that there is at least some duration of time where the content associated with both assets is present within the invoice interface 500.In some embodiments, the system of the present disclosure may be used to confirm an identity of a user for separate transactions conducted with one or more merchants for the purpose of consolidating billing.", "That is, in example illustrated in FIG.", "5, if the user validates the assets corresponding to “bethad-mac@example.com,” “scottishplay@example.com,” and “212-555-7665,” the billing for transactions associated with those assets may be consolidated with the bills for “Cauldron Cleaning Supplies” and “Banquo's Animal Supply,” by a billing system such that the user need only pay one bill to fulfill the payment obligations to all merchants associated with those transactions.", "In some embodiments, the invoice interface 500 may allow the user to input and verify new assets to be associated with the transactions.", "For example, if a user is replacing an old email address with a new email address, or has an alternate email address, the user may enter the new/alternate email address into a corresponding field (not shown) in the invoice interface 500, and the system may associate the new/alternate email account with the transactions upon successful execution of a confirmation workflow for the new/alternate asset.", "As noted in the present disclosure, in some implementations, a user may deny association with some transactions associated with an asset.", "For example, a husband, who shares an asset with a wife, may deny being associated with transactions made by the wife (e.g., through a control on the interface).", "In such a case, the details of denied transactions may be removed from the set of details, and the invoice interface 500 may be updated to remove the invoices.", "The message box 518 may also include controls (not shown) for the user to indicate assets that are not associated with the user.", "For example, if the user does not recognize the phone number “212-555-7665,” the user may click a control to notify the system that the asset has been mistakenly associated with the user by the system and does not actually belong to the user.", "The system of the present disclosure may then disassociate that asset from the identity of the user by updating one or more tables of a database (e.g., for example, assigning a new user identifier to the transaction or transactions associated with the asset, associating the asset with the next most-likely user, as determined by a supervised model of embodiments of Appendix A of U.S.", "Provisional Application No.", "62/187,620, incorporated herein by reference, or by setting flag on a field in an asset confirmation table of a database that indicates that the asset has been denied by the user), and the asset may subsequently may no longer be listed in the invoice interface 500 as an asset to validate.", "Confirmation of assets and denial of assets by users as described in the present disclosure may provide data for training the random forest of the supervised model so that it can make improve the accuracy of its determinations of user identities.", "As described in detail in the embodiments of Appendix A of U.S.", "Provisional Application No.", "62/187,620, some supervised models may be configured to determine whether two or more transactions should be associated with the same user identity, based on details associated with the transactions (e.g., given name, family name, address, Internet protocol address, birthdate, date/time of purchase, total price of the purchase, etc.).", "The random forests of the supervised models may have been trained using historical records of past transactions having at least one ground truth value.", "As explained in Appendix A of U.S.", "Provisional Application No.", "62/187,620, a “ground truth value” may refer to a value that unambiguously corresponds to a target value/objective, which in this case may be an identity of the user.", "In the present disclosure, upon confirmation of an asset by a user associated with a particular user identity, the user identity can be considered a ground truth value because the user has unambiguously confirmed that the user identity corresponds to the user.", "This ground truth value and associated data may be subsequently utilized to update/retrain the supervised model so that, over time, the accuracy of the supervised model improves.", "Similarly, when an asset is denied by a user (i.e., the user indicates the user is not associated with the asset), this too provides data that may be used to improve the accuracy of the supervised model.", "For example, transactions associated with this asset may be re-assigned to the next most likely user, and upon confirmation by that user, ground truth may be considered to be established and the supervised model can be updated/retrained with the new ground truth value.", "Alternatively, if transactions corresponding to the asset were previously used to update the supervised model (i.e., if the system incorrectly assumed that ground truth had been established for those transactions), upon denial of the asset by the user, those transactions may be disassociated from the user and may be disregarded when the supervised model is retrained/updated.", "In some implementations, an interface such as the invoice interface 500 may allow the user to confirm or deny/disavow transactions in addition to or alternative to assets.", "For example, in a situation where multiple users share the same asset (e.g., husband and wife), such as the asset 306B of FIG.", "3 shared by users 302A-02B, a first user 302A may notice that one or more transactions (e.g., the second transaction 308B) have been mistakenly associated with the first user identity 310A, when in actuality, the one or more transactions should be associated with the second user 302B (i.e., the second user identity 310B).", "The first user 302A, using functionality provided in an interface, may notify the system that the transaction should not be associated with the first user identity 310A.", "In response to receiving the notification, the system may disassociate the second transaction 308B from the first user identity 310A.", "In some cases, the system may update the association of the second transaction 308B to be associated with the second user identity 310B.", "In some of these cases, the system may prompt the second user 302B to confirm that the second transaction 308B should indeed be associated with the second user 302B before making that association.", "In any case, ground truth values for the transaction data corresponding to the second transaction 308B may be changed, and consequently the supervised model may be updated/retrained using the changed transaction data in a manner described above in order to improve the accuracy of the supervised model.", "The supervised model may be updated/retrained regularly (e.g., nightly, weekly, monthly) or irregularly from transaction data where ground truth has been established in a manner described above.", "That is, in addition to or alternative to the original historical data used to train the random forest of the supervised model, the random forest include data collected from transactions conducted by embodiments of the systems of Appendix A of U.S.", "Provisional Application No.", "62/187,620, incorporated herein by reference, and by feedback received from users of the system of the present disclosure that unambiguously connect assets and/or transactions to a particular user identity.", "FIG.", "6 illustrates an email interface 600 with an inbox containing a confirmation email message 622 received by a user in order to confirm an asset under the control of the user.", "In particular, the confirmation email message 622 has been sent to the email address given by the asset information (bethad-mac@example.com).", "The email message includes a confirmation code of “1606,” which the user may subsequently input into a field such as the at least one field 522 of an interface similar to the invoice interface 500 of FIG.", "5 to prove that the user has control of the email mailbox corresponding to that address.", "The confirmation code in the confirmation email message 622 may be configured to expire after a certain time in order to reduce the risk of unauthorized access to the email mailbox.", "Furthermore, other methods of confirmation control of the asset are also contemplated; for example, the confirmation email message 622 may contain a link with the session key that, when activated, automatically opens a browser window and confirms the receipt of the confirmation email message 622.As noted, the asset need not necessarily be an email mailbox, and in the case where the asset is a mobile telephone, rather than the confirmation email message 622, a confirmation text message may be sent to the user with a similar type of confirmation code.", "Likewise, the confirmation code may expire after a certain time period.", "In an event where the asset information is a geographical address, the confirmation message with the confirmation code may be sent by postal mail.", "FIG.", "7 is a flowchart illustrating an example of a process 700 for confirming an asset in accordance with various embodiments.", "Some or all of the process 700 (or any other processes described, or variations and/or combinations of those processes) may be performed under the control of one or more computer systems configured with executable instructions and/or other data, and may be implemented as executable instructions executing collectively on one or more processors.", "For example, some or all of process 700 may be performed by any suitable system, such as the computing device 800 of FIG.", "8.The executable instructions and/or other data may be stored on a non-transitory computer-readable storage medium (e.g., a computer program persistently stored on magnetic, optical, or flash media).", "In 702, the system performing the process 700 may receive a login request from a user wishing to view details of a previously conducted transaction, such as an invoice for a purchase of one or more items or services from an online merchant website.", "The login request may be submitted as a result of interaction with the website or other user interface and may be, for instance, a HyperText Transfer Protocol request or other electronic request submitted by a computer system that displays the user interface.", "The login request may include asset information corresponding to a first asset, such as an email address corresponding to an email mailbox or a telephone number corresponding to a mobile telephone.", "The asset information corresponding to the first asset, in some cases, may be the asset information that was input by the user at the time the transaction was conducted.", "In other cases, the asset information may be asset information that was confirmed as being associated with an asset under the control of the user according to the confirmation workflow of 712 (below).", "As noted above, examples of asset information include email addresses, telephone numbers, and may further include information such as geographical addresses, retina scans, fingerprints, and other biometric information.", "The login request may also include additional information that at least partially authenticates the user thereby indicating the likelihood that the user logging in is indeed the user that corresponds to the asset information, and not an unauthorized entity attempting to impersonate the user.", "For example, the user may make the login request also providing, into a website form or other user interface (e.g., mobile application) information such as a birthdate, a national identity number, password, a maiden name of the user's mother, name of the street the user grew up on, or some other information unlikely to be known by entities other than the user, and stored by the system for use in confirming identity of the user.", "Further included in the operations of 702 are obtaining a user identifier for the user based on information provided with the request.", "In some implementations, the user identifier may be obtained by querying a database for a user identifier associated with identifying information provided with the request (e.g., national identity number, password, fingerprint, etc.).", "In other implementations, the user identifier may be obtained by passing information received in the request through a supervised model similar to the supervised model described in the Appendix A of U.S.", "Provisional Application No.", "62/187,620, incorporated herein by reference, and receiving, as output, the user identifier that is determined to be likely associated with the user.", "In still other implementations, the user identifier may be obtained by querying a transaction database based on information provided with the request, such as the asset information.", "For example, the query may be a query to obtain a distinct user identifier associated with the particular email address passed as the asset information with the request.", "It is contemplated that there may be other methods of obtaining a user identifier in response to the request.", "Note that if the user identifier is unable to be obtained (e.g., no record returned from the query to obtain the distinct user identifier because no user identifiers were able to be matched to information that was received with the request and/or information received with the request was unable to be matched to a user matching with a high enough confidence score, as determined by a supervised model of the system of Appendix A of U.S.", "Provisional Application No.", "62/187,620 or the present disclosure), the system may determine that it is likely an attempt by an unauthorized user to log in as the legitimate user, and in such a case the system may terminate the process, or perform other security measures, and not proceed to the next operation.", "In the context of the process 700, “querying” may refer to a structured query language (SQL) query, some other database query, an application programming interface request (e.g., a web service request) to a service that vends such data, or some other method of obtaining data from a data store.", "The database may be an organized collection of data, such as tables, stored procedures, reports, views, and other database objects.", "Note that any structure configured to store and retrieve data in the manner described may be used, including file systems, relational databases, non-relational databases, object-oriented databases, comma delimited files, and other files.", "In some implementations, the structure may be a distributed data store.", "Note that the user identifier may have been generated by a supervised model in accordance with an embodiment of the system of Appendix A of U.S.", "Provisional Application No.", "62/187,620, incorporated herein by reference.", "For example, during the course of executing or recording the transaction, a record matching service of the system of Appendix A of U.S.", "Provisional Application No.", "62/187,620 may determine, based on details (which may include asset information) associated with the transaction, whether the transaction is a first transaction conducted by the user, or whether the user is the same as a user associated with one or more previous transactions, based on stored details about the previous transactions.", "The determination may be made by a likelihood/probability of the user being the same, as determined from votes of a random forest of a supervised model, exceeding a threshold (e.g., 90%).", "If the likelihood does not exceed the threshold, the system may consider the user to be a new user of the system and create a new identity for the user.", "However, if the user is determined likely to be the same user, the new transaction may be associated with an identity shared by the one or more previous transactions.", "Note that, determining transactions associated with the same user may be performed asynchronously relative to the performance of the process 700, and may occur over time as the user engages in transactions at various times, perhaps with different merchants.", "For instance, each time the user engages in a transaction involving an online payment system, the online payment system may determine that the transaction is associated with the user and store the transaction in association with the user (e.g., by associating the transaction with an identifier of the user) in a database.", "Furthermore, asset information (e.g., email address, telephone number, etc.)", "may also be stored with the transaction in association with the user.", "In 703, the system performing the process 700 may determine whether the asset associated with the first asset information (i.e., the asset information provided by the user in the login request of 702) has been confirmed as being under the control of the user.", "In other words, the system may determine whether this is the first time that the user has attempted to log in using the first asset information.", "Note that embodiments of the present disclosure may be implemented in a distributed computing environment, thus it is contemplated that in some implementations, the system receiving the request may be a different system than the system making the determination whether the asset has been confirmed.", "For example, the system performing the process 700 may make an application programming interface call to a backend server or service requesting the determination, which, in return, may make the determination and provide the result to the system performing the process 700.Note too, in some implementations, confirmation of the first asset information in accordance with the confirmation workflow of 712 may not be performed on initial login to verify the first asset, because the system may presume, based on information provided with the login information in 702, that the first asset is already under the control of the user.", "In other implementations, confirmation in accordance with the confirmation workflow of 712 of the first asset information may be performed each time the user logs in with that asset information.", "In some embodiments, the request to log in may itself include information confirming ownership of an asset, such as if the request includes biometric information or if the user interface collects such information before the request is submitted to the system performing the process 700.In some implementations of the present disclosure, a database table (“confirmation table”) with at least fields for a user identifier and asset information or asset identifier may be present for storing whether assets are confirmed or not.", "In some cases, the table may include additional fields, such as fields for asset type, confirmation status, and so on.", "In some cases, if the user has not previously logged in with an asset, the user may not yet have an entry in the confirmation table.", "Thus, upon initial login by the user, the system performing the process 700 may execute a query on the confirmation table to determine whether the first asset has already been confirmed (i.e., information in the confirmation table associated with the first asset information indicating that the asset has been confirmed) in association with the identity of user logging in (e.g., in some cases, this may simply be an entry of the asset information in the confirmation table in association with the user identifier associated with the user, in other cases this may include a check of a confirmation status field in the confirmation table associated with the asset information and an identifier associated with the user, etc.).", "As noted above, it is contemplated that embodiments of the present disclosure may be implemented in a distributed computing environment; e.g., some portions of the process 700 may be performed by a web server while other portions of the process 700 may be performed by one or more database servers.", "Thus, the query in some implementations may be performed by a different system than the system that received the request of 702.For example, the system performing the process 700 may make an application programming interface call requesting the query to a backend server or service, which, in return, may make the perform the query and provide records returned to the system performing the process 700.Thus, if the query returns no records or if the query returns a confirmation status of unconfirmed, the system performing the process may proceed to 712.Otherwise, if the first asset has been determined to be confirmed, the system performing the process may proceed to 704.In 704, the system may query the confirmation table to obtain a set of records containing asset information of confirmed assets.", "As noted above, in some implementations the query may be performed by a separate system (e.g., database server, or some other backend server or service).", "Note that in some implementations, this list of asset information may have already been obtained when the confirmation table was queried in 703.For example, the confirmation table was queried in 703 against the user identifier, and a set of records containing asset information corresponding to confirmed assets may have been obtained.", "If the set of records was an empty set or if an examination of the set of records revealed that the first asset was not a member of the set, the system performing the process would have instead proceeded to 712 from 703.Consequently, at 704 the set of records containing asset information of confirmed assets may have already been obtained.", "Alternatively, rather than using a confirmation table, each transaction record in the transaction database corresponding to transactions performed by the user may be linked to or include asset information for confirmed assets for those transactions.", "Note that, in the context of FIG.", "7, a “confirmed asset” may refer to an asset of which the user has proven ownership or has proven possession and control.", "Next, the system may obtain a set of transactions that correspond to the confirmed assets obtained above.", "For example, a user may have input a telephone number as asset information when purchasing new shoes from an online merchant at a first time.", "At a second time, the user may have input an email address as asset information when purchasing a brand-new bag in another online purchase.", "An embodiment of the system of Appendix A, as previously described, may determine that the orders for the new shoes and brand-new bag are likely from the same user, and consequently assign the same user identifier to both transactions.", "In this example, upon logging in with the telephone number to check the order status of the new shoes, the system performing the process 700 may confirm the mobile phone (first asset) corresponding to the telephone number.", "For example, the system may cause a short message service (SMS) message to be sent to the telephone number, or may utilize another method of confirmation, such as described below.", "Upon confirmation of the mobile phone, the system performing the process 700 may retrieve the transaction corresponding to the new shoes.", "However, the transaction corresponding to the brand-new bag may not be retrieved, because the asset associated with the brand-new bag transaction, the email account, has not yet been confirmed.", "At a time after the user also confirms the email account corresponding to the email address, if the user logs in using either the asset information of the telephone number or the email address, the system may retrieve both the transaction corresponding to the new shoes and the transaction corresponding to the brand-new bag.", "The details for the transactions may be displayed in an interface such as the invoice interface 500 of FIG.", "5.In 712, the system performing the process 700 may perform a confirmation workflow to confirm the asset corresponding to the asset information received in the login request of 702.As has been described in the present disclosure, the confirmation workflow may include sending a message to a location indicated by the asset information being confirmed.", "For example, the system may send a text message (e.g., an SMS message) to a device associated with a provided telephone number, or may send an email message to an email account/mailbox corresponding to a provided email address.", "A method by which the user can confirm receipt of the message, consumption of the message, and consent to associate the asset with the user identifier includes providing a unique code (e.g., a one-time password) in the message, and the user can input the unique code into a field of a webpage, submit the unique code from the webpage to the system performing the process 700, and the system can confirm that the received code matches the code that was sent.", "If the code does not match, the asset is not confirmed and the process 700 may be terminated and/or other security precautions may be executed by the system.", "In some cases, the unique code may be configured to expire after a certain amount of time, and in such cases, even if the unique code received does match the unique code sent, the asset may not be confirmed, as described above, because the unique code has expired.", "Similarly, a uniform resource locator may be embedded as a link in the message, and rather than requiring the user to manually enter a code into an interface, the message link may be clicked or otherwise activated by the user from the asset, which may cause a webpage to open and submit confirmation data to the system performing the process 700.As still another example, the system may place an automated voice call to a telephone associated with the telephone number, and automated voice call may provide an audio code (e.g., series of numbers and/or letters, one or more words, a phrase, etc.)", "to the user who answers the telephone, and the audio code may be entered in a similar manner as unique code provided in a text message.", "It is contemplated that other methods of confirming an asset, based on the provided asset information, are possible.", "Once the asset has been confirmed, the system performing the process may store data indicating the confirmation of that asset.", "For example, the system may insert a record in the confirmation table that includes at least the user identity and the asset information that was just confirmed.", "As noted, in some implementations, the system may additionally insert information indicating the type of asset associated with the asset information and/or set a status flag indicating that the asset has been confirmed.", "Note that in other implementations where asset information and information indicating confirmation of assets are stored on a per transaction basis, the system at this stage may update corresponding transactions to indicate that assets have been confirmed.", "Thus, in either case, when a user logs in with asset information corresponding to any asset that has been confirmed for the user, the user may be provided access to details of all transactions that correspond to confirmed assets for that user.", "In 710, the system performing the process 700 may determine whether there are additional unconfirmed assets (e.g., second assets) associated with the user identifier.", "This determination may be made by querying a transaction database for asset information (e.g., phone number, email address, etc.)", "provided with transactions that corresponded to the user (i.e., have been associated with the user identifier), but where the asset information provided with those transactions is not present within the set of asset information for confirmed assets, described above.", "As noted above, the actual determination and/or query may be performed by a separate system than the system performing the process 700.For example, the system performing the process 700 may be a web server and the determination and/or query may be performed by a backend server or service.", "Thus, it is contemplated that embodiments of the present disclosure may be implemented in a distributed computing environment.", "Thus, in the example above, after the user confirms control of the telephone associated with the telephone number, the system may determine, by performing a query of the transactions associated with the customer identifier, that the email address corresponding to the brand-new bag transaction has not been confirmed.", "In another example, expanding on the example above, after the user has confirmed the telephone number associated with the purchase of the new shoes, the user purchases a pair of cheap sunglasses in a third transaction.", "In this third transaction, the user provides a second email address, different from the first email address provided for the brand-new bag transaction, as asset information for this third transaction.", "If the user logs into the system of the present disclosure using the first email address (i.e., the one that corresponds to the brand-new bag transaction), in the operations of 710, the system may discover the second email address during the query of the transaction database for asset information corresponding to unconfirmed assets.", "In such cases, the system may proceed to 711, whereupon the system may provide the user with the ability to confirm an asset corresponding to the newly discovered asset information (i.e., the email address).", "As depicted in the invoice interface 500 of FIG.", "5, this may include listing asset information associated with unconfirmed assets, and providing controls to the user that initiate the confirmation workflow of 712 for that asset.", "It is contemplated various other manners of providing users with the ability to confirm unconfirmed assets are possible.", "In additional or alternative embodiments, a user may only be able to access details corresponding to transactions associated with assets that were confirmed during a particular login session.", "For example, at a first time, a user logs into the system of the present disclosure with first asset information and confirms assets associated with the first asset information (first asset) as well as assets associated with second and third asset information (second and third assets).", "At a second time, the user logs into the system of the present disclosure using fourth asset information and confirms the asset associated with the fourth asset information.", "However, because the fourth asset was not confirmed at the first time (e.g., the transaction corresponding to the fourth asset may have occurred after the transactions associated with the first, second, and third assets), and because none of the first, second, and third assets have been confirmed at the second time, the user may be unable to view the transactions associated with the first, second, and third assets (i.e., they are not yet linked together).", "However, at the second time, the user may be prompted (e.g., via a web interface) to confirm any of the first, second, and third assets, and upon confirming any of those assets, all four assets may be linked (e.g., stored in association with each other in a database), and the user may be able to view details from any of the first, second, third, and fourth assets.", "Likewise, if the user logs in at a third time using asset information associated with any of the first, second, or third assets, the user may be prompted to confirm the fourth asset, and, upon confirmation, the user may be able to view details from any of the first, second, third, and fourth assets (e.g., because they will all be linked together).", "In short, until such time as the system performing the process 700 receives confirmation that the assets associated with one or more transactions are under the control of the user, the system may deny access to details of the associated one or more transactions.", "After the system receives acknowledgement (e.g., input of a matching confirmation code into a user interface, indication that the user has clicked on an appropriate link in a message sent to a location indicated by asset information, receiving a reply to a sent message, etc.)", "that the assets are under the control of the user, the system may update relevant database records to indicate that the assets have been confirmed for the user.", "In some implementations, the update to relevant database records may include updating one or more transaction tables, whereas in other implementations the update to relevant database records may include updating one or more asset confirmation tables separate from the transaction tables.", "In either case, the user may subsequently be provided access to details of the transactions associated with the newly-confirmed assets.", "In other words, as a result of storing the information indicating that the assets have been confirmed, the user may be enabled to view all transactions associated with any confirmed asset simply by logging in using one of confirmed assets.", "Once an asset has been confirmed, if the user subsequently logs in using the associated asset information, that asset may not need to be reconfirmed.", "However, in some implementations, the system performing the process 700 may force the user to reconfirm assets on a periodic (e.g., once every three months) or stochastic basis for security purposes, or may force the user to reconfirm assets based on the occurrence of certain events or fulfillment of certain conditions (e.g., user logs in from an Internet protocol address that is not recognized by the system as being previously associated with the user, a number of failed login attempts exceed the threshold, etc.).", "Note further that one or more of the operations performed in 702-13 may be performed in various orders and combinations, including in parallel.", "Note also that, unless otherwise specified, use of expressions regarding executable instructions (also referred to as code, applications, agents, etc.)", "performing operations that instructions do not ordinarily perform unaided (e.g., transmission of data, calculations, etc.)", "in the context of describing disclosed embodiments denote that the instructions are being executed by a machine (e.g., computer configured with processors that process the instructions), thereby causing the machine to perform the specified operations.", "Embodiments of the disclosure can be described in view of the following clauses: 1.A computer-implemented method, comprising: under the control of one or more computer systems configured with executable instructions, receiving a plurality of field values generated based at least in part on first user input, the plurality of field values including a field value corresponding to a first asset associated with a user; performing a first workflow to verify control of the first asset by the user; selecting, from a plurality of transactions, a first set of transactions associated with both the user and the first asset; determining a second asset associated with the user; updating a user interface to present, simultaneously, first content representing the first set of transactions and second content representing the second asset associated with the user; receiving a selection of the second asset made via the updated user interface; performing a second workflow to verify control of the second asset by the user, the second workflow comprising: sending a message to a location associated with the second asset; and receiving information that verifies acknowledgement of receipt of the message; and contingent on receiving the information that verifies acknowledgment of receipt of the message: selecting, from the plurality of transactions, a second set of transactions associated with both the user and the second asset; and updating the user interface to present, simultaneously, the first content and second content representing the second set of transactions.", "2.The computer-implemented method of clause 1, wherein: the plurality of field values is a first plurality of field values; the field value is a first field value; the method further comprising: receiving a second plurality of field values generated based at least in part second user input, the second plurality of field values including a second field value corresponding to either the first asset or the second asset; without performing any of the first workflow or the second workflow: selecting from the plurality of transactions, the first set of transactions and the second set of transactions; and presenting content representing the first set of transactions and the second set of transactions in the user interface.", "3.The computer-implemented method of clause 1 or 2, wherein the plurality of field values lack values for both username and password.", "4.The computer-implemented method of any of clauses 1 to 3, further comprising, contingent on receiving the information that verifies acknowledgment of receipt of the message, updating a database storing the plurality of transactions such that one or more records in the database indirectly associating the first set of transactions with the second set of transaction by indicating confirmation of control by the user of both the first asset and the second asset.", "5.A system, comprising: one or more processors; memory including instructions that, when executed by the one or more processors, cause the system to: obtain a field value corresponding to a first asset associated with a user; select, from a plurality of records, a first set of records associated with the user and the first asset; determine a second asset associated with the user; present a user interface that includes content representing the first set of records and an option to verify the second asset; in response to receiving a selection of the option, perform a confirmation workflow to verify control of the second asset by the user; and as a result of successful execution of the confirmation workflow: select, from the plurality of records, a second set of records associated with the user and the second asset; and update the user interface to include content representing the second set of records.", "6.The system of clause 5, wherein the confirmation workflow includes: causing an electronic message to be transmitted to one or more of an email account or a mobile device, wherein the electronic message includes a confirmation code; receiving a code from a device via an interface to the system; and based at least in part on whether the code matches the confirmation code, outputting at least one value that indicates either the successful execution or an unsuccessful execution of the confirmation workflow.", "7.The system of clause 5 or 6, wherein instructions further include instructions that cause the system to, as a result of successful execution of the confirmation workflow: update an association of the first set of records to include the second asset; and update an association of the second set of records to include the first asset.", "8.The system of any of clauses 5 to 7, wherein the instructions that cause the system to determine the second asset associated with the user further include instructions that cause the system to determine, based at least in part on a confidence score provided by a random forest, that the second set of records are associated with a same user as the first set of records.", "9.The system of clauses 8, wherein the instructions further include instructions that cause the system to, as a result of the successful execution of the confirmation workflow, include the second set of records, using an identity of the user as a ground truth value, in a set of historical records used to train training the random forest.", "10.The system of any of clauses 5 to 8, wherein the instructions further include instructions that cause the system to, in response to receiving an instruction to disassociate the first asset: disassociate the first asset from the first set of records; and disassociate the first asset from the second set of records.", "11.The system of clause 10, wherein the instructions further include instructions that cause the system to, as a result of receiving a request to access the first set of records or the second set of records, wherein the request includes a field value corresponding to the second asset: select the first set of records and the second set of records from a plurality of records; and present the user interface that includes the content representing the first set of records and the second set of records.", "12.The system of clause 10 or 11, wherein the instructions further include instructions that cause the system to, as a result of receiving a request to access the first set of records or the second set of records, wherein the request includes a field value corresponding to the disassociated first asset, blocking access to the first set of records and the second set of records.", "13.A non-transitory computer-readable storage medium having stored thereon executable instructions that, when executed by one or more processors of a computer system, cause the computer system to at least: obtain first asset information that corresponds to a first asset associated with a user; determine a first set of records associated with the user and the first asset; determine a second set of records associated with the user, the second set of records including second asset information corresponding to a second asset; and based at least in part on obtaining confirmation from the user that the second asset is under the control of the user: associate both the first set of records and the second set of records with both the first asset information and the second asset information; and provide, to a computing device associated with the user, details about the first set of records and the second set of records.", "14.The non-transitory computer-readable storage medium of clause 13, wherein: the user is a current user; the first asset is shared by a first user and a second user; and the instructions further include instructions that cause the computer system to: obtain distinguishing information corresponding to the current user; and determine which of the first user or the second user is the current user based at least in part on the distinguishing information.", "15.The non-transitory computer-readable storage medium of clause 13 or 14, wherein the instructions further include instructions that cause the computer system to determine from a database that the first asset has not been verified in association with the user; attempt to verify that the first asset is under the control of the user by performing an asset confirmation workflow based at least in part on the first asset information; and based at least in part on successful verification of the first asset, indicate in the database that the first asset has been verified.", "16.The non-transitory computer-readable storage medium of any of clauses 13 to 15, wherein the instructions include instructions that cause the computer system to: determine whether confirmation has been obtained from the user that the second asset is under the control of the user; and based at least in part on a determination that the confirmation has not been obtained, successfully perform a confirmation workflow to obtain the confirmation.", "17.The non-transitory computer-readable storage medium of any of clauses 13 to 16, wherein the instructions further include instructions that cause the computer system to, based at least in part on obtaining denial from the user that the second asset is under the control of the user: disassociate the second set of records from the first set of records; and provide, to the user, details about the first set of records.", "18.The non-transitory computer-readable storage medium of any of clauses 13 to 17, wherein the instructions that cause the computer system to determine the second set of records associated with the user include instructions that cause the computer system to determine, based at least in part on a confidence score exceeding a threshold, wherein the confidence score is produced by a random forest trained on a plurality of records, that the second set of records and the first set of records correspond to a same user.", "19.The non-transitory computer-readable storage medium of clause 18, wherein: each of the plurality of records include at least one record comprising a set of field values corresponding to a transaction, wherein the set of field values include a ground truth value corresponding to a user identity; at least some of the field values of the second set of records include an identity of the user; and the instructions further include instructions that cause the computer system to, based at least in part on obtaining confirmation from the user that the second asset is under the control of the user, retrain the random forest to include the at least some field values of the second set of records, wherein the identity of the user is the ground truth value.", "20.The non-transitory computer-readable storage medium of clause 18 or 19, wherein: each of the plurality of records include at least one record comprising a set of field values corresponding to a transaction, wherein the set of field values include a ground truth value corresponding to a user identity; and the instructions further include instructions that cause the computer system to, based at least in part on obtaining denial from the user that the second asset is under the control of the user, retrain the random forest to exclude field values of the second set of records as having a ground truth value corresponding to an identity of the user.", "FIG.", "8 is an illustrative, simplified block diagram of an example computing device 800 that may be used to practice at least one embodiment of the present disclosure.", "In various embodiments, the computing device 800 may be used to implement any of the systems illustrated herein and described above.", "For example, the computing device 800 may be configured for use as a data server, a web server, a portable computing device, a personal computer, or any electronic computing device.", "As shown in FIG.", "8, the computing device 800 may include one or more processors 802 that may be configured to communicate with, and are operatively coupled to, a number of peripheral subsystems via a bus subsystem 804.The processors 802 may be utilized for the traversal of decision trees in random forest of supervised models in embodiments of the present disclosure (e.g., cause the evaluation of inverse document frequencies of various search terms, etc.).", "These peripheral subsystems may include a storage subsystem 806, comprising a memory subsystem 808 and a file storage subsystem 810, one or more user interface input devices 812, one or more user interface output devices 814, and a network interface subsystem 816.Such storage subsystem 806 may be used for temporary or long-term storage of information such as details associated with transactions described in the present disclosure, databases of historical records described in the present disclosure, and storage of decision rules of the supervised models in the present disclosure).", "The bus subsystem 804 may provide a mechanism for enabling the various components and subsystems of computing device 800 to communicate with each other as intended.", "Although the bus subsystem 804 is shown schematically as a single bus, alternative embodiments of the bus subsystem may utilize multiple busses.", "The network interface subsystem 816 may provide an interface to other computing devices and networks.", "The network interface subsystem 816 may serve as an interface for receiving data from, and transmitting data to, other systems from the computing device 800.For example, the network interface subsystem 816 may enable a data technician to connect the device to a wireless network such that the data technician may be able to transmit and receive data while in a remote location, such as a user data center.", "The bus subsystem 804 may be utilized for communicating data, such as details, search terms, and so on to the supervised model of the present disclosure, and may be utilized for communicating the output of the supervised model to the one or more processors 802 and to merchants and/or creditors via the network interface subsystem 816.The user interface input devices 812 may include one or more user input devices, such as a keyboard, pointing devices such as an integrated mouse, trackball, touchpad, or graphics tablet, a scanner, a barcode scanner, a touch screen incorporated into the display, audio input devices such as voice recognition systems, microphones, and other types of input devices.", "In general, use of the term “input device” is intended to include all possible types of devices and mechanisms for inputting information to the computing device 800.The one or more user interface output devices 814 may include a display subsystem, a printer, or non-visual displays such as audio output devices, etc.", "The display subsystem may be a cathode ray tube (CRT), a flat-panel device such as a liquid crystal display (LCD), light emitting diode (LED) display, or a projection or other display device.", "In general, use of the term “output device” is intended to include all possible types of devices and mechanisms for outputting information from the computing device 800.The one or more output devices 814 may be used, for example, to present user interfaces to facilitate user interaction with applications performing processes described herein and variations therein, when such interaction may be appropriate.", "The storage subsystem 806 may provide a computer-readable storage medium for storing the basic programming and data constructs that may provide the functionality of at least one embodiment of the present disclosure.", "The applications (programs, code modules, instructions) that, when executed by one or more processors, may provide the functionality of one or more embodiments of the present disclosure, and may be stored in the storage subsystem 806.These application modules or instructions may be executed by the one or more processors 802.The storage subsystem 806 may additionally provide a repository for storing data used in accordance with the present disclosure.", "The storage subsystem 806 may comprise a memory subsystem 808 and a file/disk storage subsystem 810.The memory subsystem 808 may include a number of memories, including a main random access memory (RAM) 818 for storage of instructions and data during program execution and a read only memory (ROM) 820 in which fixed instructions may be stored.", "The file storage subsystem 810 may provide a non-transitory persistent (non-volatile) storage for program and data files, and may include a hard disk drive, a floppy disk drive along with associated removable media, a Compact Disk Read Only Memory (CD-ROM) drive, an optical drive, removable media cartridges, and other like storage media.", "The computing device 800 may include at least one local clock 824.The local clock 824 may be a counter that represents the number of ticks that have transpired from a particular starting date and may be located integrally within the computing device 800.The local clock 824 may be used to synchronize data transfers in the processors for the computing device 800 and all of the subsystems included therein at specific clock pulses and may be used to coordinate synchronous operations between the computing device 800 and other systems in a data center.", "In one embodiment, the local clock 824 is an atomic clock.", "In another embodiment, the local clock is a programmable interval timer.", "The computing device 800 may be of various types, including a portable computer device, tablet computer, a workstation, or any other device described below.", "Additionally, the computing device 800 may include another device that may be connected to the computing device 800 through one or more ports (e.g., USB, a headphone jack, Lightning connector, etc.).", "The device that may be connected to the computing device 800 may include a plurality of ports configured to accept fiber-optic connectors.", "Accordingly, this device may be configured to convert optical signals to electrical signals that may be transmitted through the port connecting the device to the computing device 800 for processing.", "Due to the ever-changing nature of computers and networks, the description of the computing device 800 depicted in FIG.", "8 is intended only as a specific example for purposes of illustrating the preferred embodiment of the device.", "Many other configurations having more or fewer components than the system depicted in FIG.", "8 are possible.", "The specification and drawings are, accordingly, to be regarded in an illustrative rather than a restrictive sense.", "However, it will be evident that various modifications and changes may be made thereunto without departing from the broader spirit and scope of the invention as set forth in the claims.", "Other variations are within the spirit of the present disclosure.", "Thus, while the disclosed techniques are susceptible to various modifications and alternative constructions, certain illustrated embodiments thereof are shown in the drawings and have been described above in detail.", "It should be understood, however, that there is no intention to limit the invention to the specific form or forms disclosed, but on the contrary, the intention is to cover all modifications, alternative constructions and equivalents falling within the spirit and scope of the invention, as defined in the appended claims.", "The use of the terms “a” and “an” and “the” and similar referents in the context of describing the disclosed embodiments (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context.", "The terms “comprising,” “having,” “including” and “containing” are to be construed as open-ended terms (i.e., meaning “including, but not limited to,”) unless otherwise noted.", "The term “connected,” when unmodified and referring to physical connections, is to be construed as partly or wholly contained within, attached to or joined together, even if there is something intervening.", "Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein and each separate value is incorporated into the specification as if it were individually recited herein.", "The use of the term “set” (e.g., “a set of items”) or “subset” unless otherwise noted or contradicted by context, is to be construed as a nonempty collection comprising one or more members.", "Further, unless otherwise noted or contradicted by context, the term “subset” of a corresponding set does not necessarily denote a proper subset of the corresponding set, but the subset and the corresponding set may be equal.", "Conjunctive language, such as phrases of the form “at least one of A, B, and C,” or “at least one of A, B and C,” unless specifically stated otherwise or otherwise clearly contradicted by context, is otherwise understood with the context as used in general to present that an item, term, etc., may be either A or B or C, or any nonempty subset of the set of A and B and C. For instance, in the illustrative example of a set having three members, the conjunctive phrases “at least one of A, B, and C” and “at least one of A, B and C” refer to any of the following sets: {A}, {B}, {C}, {A, B}, {A, C}, {B, C}, {A, B, C}.", "Thus, such conjunctive language is not generally intended to imply that certain embodiments require at least one of A, at least one of B and at least one of C each to be present.", "Operations of processes described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context.", "Processes described herein (or variations and/or combinations thereof) may be performed under the control of one or more computer systems configured with executable instructions and may be implemented as code (e.g., executable instructions, one or more computer programs or one or more applications) executing collectively on one or more processors, by hardware or combinations thereof.", "The code may be stored on a computer-readable storage medium, for example, in the form of a computer program comprising a plurality of instructions executable by one or more processors.", "The computer-readable storage medium may be non-transitory.", "The use of any and all examples, or exemplary language (e.g., “such as”) provided herein, is intended merely to better illuminate embodiments of the invention and does not pose a limitation on the scope of the invention unless otherwise claimed.", "No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the invention.", "Embodiments of this disclosure are described herein, including the best mode known to the inventors for carrying out the invention.", "Variations of those embodiments may become apparent to those of ordinary skill in the art upon reading the foregoing description.", "The inventors expect skilled artisans to employ such variations as appropriate and the inventors intend for embodiments of the present disclosure to be practiced otherwise than as specifically described herein.", "Accordingly, the scope of the present disclosure includes all modifications and equivalents of the subject matter recited in the claims appended hereto as permitted by applicable law.", "Moreover, any combination of the above-described elements in all possible variations thereof is encompassed by the scope of the present disclosure unless otherwise indicated herein or otherwise clearly contradicted by context.", "All references, including publications, patent applications, and patents, cited herein are hereby incorporated by reference to the same extent as if each reference were individually and specifically indicated to be incorporated by reference and were set forth in its entirety herein." ] ]
Patent_15875977
[ [ "SYSTEM AND METHODS FOR DIRECT CONNECTIONS BETWEEN PREVIOUSLY UNCONNECTED NETWORK DEVICES ACROSS ONE OR MORE UNKNOWN NETWORKS", "The invention presented herein is a system and method for automatically discovering communication capabilities for direct communication between endpoints across one or more unknown networks, the system comprising: a plurality of network enabled endpoints configured with a module in wireless communication with a management database, the module configured to establish a communication path for direct communication between the network-enabled endpoints, independent of a NAT router.", "Also disclosed is a system and method for indirect connectionless bi-directional messaging over an unknown network infrastructure for communicating a message communication between a querying device and a database, wherein communication is enabled without the requirement for direct access to the database for either obtaining or placing information; and where the message communication comprises an unlimited amount of discreet and selectable information elements; and without requiring or issuing a direct acknowledgement of a receipt from the database of the communication message received." ], [ "1.A system configured for automatically discovering communication capabilities for direct communication between endpoints across one or more unknown networks, the system comprising: a plurality of network enabled endpoints configured with a module in network communication with a management database, the module configured to establish a communication path for direct communication between the network-enabled endpoints, independent of a NAT router.", "2.The system of claim 1, wherein the endpoints are one or both of network enabled devices or applications.", "3.The module of claim 3, wherein the module is configured for performing a set of operations, comprising: assessing the network to discover behavioral traits of a NAT router of a network associated with the endpoints, comprising: collecting public IP address; assessing a number of hops; sending a stream of packets embedded with an authenticated source mac address within the contents of the packets across a range of ports to a public server; discovering port information of the endpoints based on the packets and sending port information to the server; permitting the endpoints to exchange information received on the designated server regarding an endpoint; and performing an iterative operational cycle until establishing a connection path between two previously unconnected endpoints, the operation cycle comprising: a public detection to determine if one endpoint is using a public IP Address or is located in a network that allows a connection to the device on an available port, including TCP 80, 443 and UDP 53; a port mapping operation comparing sending a series of packets, sent from one endpoint in incremental ports upwards and in reverse from another endpoint in incremental ports downwards to assess if the packets intersect on a port, thereby synchronizing the endpoints on a single port, so that the incoming packets appear to be in response to the outgoing packet, thereby allowing a hand-off to occur between two endpoints; and completing a TTL manipulation operation comprising: utilizing the number of hops required to get from a local network to the public server, defining and sending packets from the local network to the public server with a first set of packets having a manipulated TTL, thereby causing the packet to be dropped in transit and to allow the NAT router to see outgoing traffic and opening holes in the NAT router, and in turn establishing, based on the open holes in the NAT router identified, a “normal” value thereby allowing packet transmission from both ends, attempting to make an end to end connection so that once established a tunnel between the endpoints is created using the same source and destination IP address and ports.", "4.A method for establishing a direct connection between previously unconnected network-enabled endpoints, comprising performing, via a module stored on the unconnected network-enabled endpoints a public detection step for establishing a public connection and if available allowing the enabled device to utilize the public port to create a direct link between the devices; and if no connection is established then allowing, via the module, a port mapping and synchronization operation to establish a stream of packets sent from each endpoint until the packets intersect on the same port and are synchronized so that the incoming packets appear to be in response to the outgoing packet; and if no connection is established, completing a TTL manipulation operation comprising: utilizing the number of hops required to get from a local network to the public server, defining and sending packets from the local network to the public server with a first set of packets having a manipulated TTL, thereby causing the packet to be dropped in transit and to allow the NAT router to see outgoing traffic and opening holes in the NAT router, and in turn establishing, based on the open holes in the NAT router identified, a “normal” value thereby allowing packet transmission from both ends, attempting to make an end to end connection so that once established a tunnel between the endpoints is created using the same source and destination IP address and ports.", "5.A computer-implemented product for use with a network-enabled device, said product comprising the module of claim 3, wherein the module is configured for automatically discovering communication capabilities between network-enabled devices whereon the module operates and is stored, for a direct communication link between the previously unconnected endpoints across one or more unknown networks, the module configured to establish a communication path for direct communication between the network-enabled endpoints, independent of a NAT router" ], [ "<SOH> BACKGROUND <EOH>In applications where there is a tunnel to a remote network it is often desirable to have traffic destined for the non-tunneled network to simply egress the local router towards the Internet.", "In typical VPN or Tunnel networks this is called a split-tunnel.", "Split tunneling is a computer networking concept which allows a VPN user to access a public network, e.g., the Internet, and a local LAN or WAN at the same time, using the same physical network connection.", "This connection service is usually facilitated through a program such as a VPN client software application.", "In VPNs, there are basically two types of virtual tunnels that enable secure data transmission: full tunnels and split tunnels.", "In full tunnel mode, a remote user.", "establishes an Internet connection from a client device, such as a PC, which then runs through the VPN.", "This naturally includes the user's private data traffic.", "As a result, every time the user scans the web, it is done through the VPN gateway.", "For example, suppose a user utilizes a remote access VPN software client connecting to a corporate network using a hotel wireless network.", "The user with split tunneling enabled is able to connect to file servers, database servers, mail servers and other servers on the corporate network through the VPN connection.", "When the user connects to Internet resources (web sites, FTP sites, etc.)", "the connection request goes directly out the gateway provided by the local network.", "Usually, this network traffic behavior is accomplished via routing statements.", "But, in a transparent tunnel network architecture where there is no routing and a split-tunnel configuration would require manual configuration of all the network elements along the path.", "Split tunneling has a variety of advantages.", "It only transmits data that actually requires the protection of a VPN, and it enables strict separation of corporate Internet traffic and private Internet use.", "Split tunneling manageability, however, depends on the quality of the implemented VPN components." ], [ "<SOH> SUMMARY <EOH>The invention presented herein permits split-routing to occur without any changes, modifications, or configuration of the requesting host, network stacks, network architectures and routing and forwarding behavior.", "The invention is carried out by way of a Module that intercepts the normal and standard DHCP communication between a requesting device and a DHCP server, and substitutes the elements within the server response with the Module's own elements.", "These substitute elements leverage the behavior of standard protocols to gain desired device network behavior.", "Existing methods known in the art require setup of multiple LAN servers and/or routers (network elements) each with their own connectivity information or modification to the hosts to make use of split-tunnel.", "There is no known automatic method for dynamic IP addressing schemes.", "Also, the fixed methods also are a waste of limited network resources.", "There are no known methods which provide selectivity on a host basis to force some hosts to be use the tunnel exclusively in a compulsory mode and others to use the split tunnel while coexisting on the same LAN.", "Described herein is a method of substituting network addressing elements with predefined information, thereby managing the flow of network traffic as it seeks egress to an alternate network, comprising: presenting an interface for intercepting a reply to a devices-DHCP request; substituting the reply with predefined information; and enabling a split-tunnel; substituting an IP address of an issuing DHCP server with an IP address of a local terminal; and forwarding resulting traffic on from the local terminal to a predetermined interface based on a destination of that address.", "Also described is a computer software product for use with a computer, said computer software product comprising, and a module constructed and arranged to be embedded into a computer program, wherein the module is operable to provide substitution addressing elements to a DHCP-requesting device.", "Another embodiment of the present invention is a computer-readable storage medium storing an executable computer program module for enabling substituting network addressing elements, the module comprising: an intercept sub-module configured to manage DHCP information between networks; an elements sub-module configured to obtain and establish the network items to be substituted; and a substitution sub-module configured to perform the operations of deconstructing, substituting, and rebuilding packets with predefined information, thereby allowing the module to manage the flow of network traffic as it seeks egress to an alternate network.", "Yet another embodiment of the present invention is a method to permit split-routing to occur without any changes, modifications or configuration of a requesting host, network stack, network architecture, and routing and forwarding behavior, the method comprising: presenting a module to intercept the normal and standard DHCP communication between a requesting device and a DHCP server, wherein the module is configured for substituting the elements within the server response with the module's own elements, thereby directing traffic through an alternate route.", "The summary is an overview of the concept in a simplified form and not intended to identify essential features of the claimed subject matter, nor is it necessarily intended to be used as an aid in determining the scope of the claimed subject matter." ], [ "RELATED APPLICATIONS This is a continuation application of U.S. patent application Ser.", "No.", "15/206,830 filed Jul.", "11, 2016, which is a continuation of U.S. patent application Ser.", "No.", "14/185,395 filed Feb. 20, 2014, which in turn claims priority to U.S.", "Provisional Patent Application No.", "61/767,229 filed on Feb. 20, 2013, the contents of which are hereby incorporated by reference in its entirety.", "FIELD OF INVENTION This application relates to the technical field of network communications; in particular, to Dynamic Host Configuration Protocol (DHCP) and network address modification.", "BACKGROUND In applications where there is a tunnel to a remote network it is often desirable to have traffic destined for the non-tunneled network to simply egress the local router towards the Internet.", "In typical VPN or Tunnel networks this is called a split-tunnel.", "Split tunneling is a computer networking concept which allows a VPN user to access a public network, e.g., the Internet, and a local LAN or WAN at the same time, using the same physical network connection.", "This connection service is usually facilitated through a program such as a VPN client software application.", "In VPNs, there are basically two types of virtual tunnels that enable secure data transmission: full tunnels and split tunnels.", "In full tunnel mode, a remote user.", "establishes an Internet connection from a client device, such as a PC, which then runs through the VPN.", "This naturally includes the user's private data traffic.", "As a result, every time the user scans the web, it is done through the VPN gateway.", "For example, suppose a user utilizes a remote access VPN software client connecting to a corporate network using a hotel wireless network.", "The user with split tunneling enabled is able to connect to file servers, database servers, mail servers and other servers on the corporate network through the VPN connection.", "When the user connects to Internet resources (web sites, FTP sites, etc.)", "the connection request goes directly out the gateway provided by the local network.", "Usually, this network traffic behavior is accomplished via routing statements.", "But, in a transparent tunnel network architecture where there is no routing and a split-tunnel configuration would require manual configuration of all the network elements along the path.", "Split tunneling has a variety of advantages.", "It only transmits data that actually requires the protection of a VPN, and it enables strict separation of corporate Internet traffic and private Internet use.", "Split tunneling manageability, however, depends on the quality of the implemented VPN components.", "SUMMARY The invention presented herein permits split-routing to occur without any changes, modifications, or configuration of the requesting host, network stacks, network architectures and routing and forwarding behavior.", "The invention is carried out by way of a Module that intercepts the normal and standard DHCP communication between a requesting device and a DHCP server, and substitutes the elements within the server response with the Module's own elements.", "These substitute elements leverage the behavior of standard protocols to gain desired device network behavior.", "Existing methods known in the art require setup of multiple LAN servers and/or routers (network elements) each with their own connectivity information or modification to the hosts to make use of split-tunnel.", "There is no known automatic method for dynamic IP addressing schemes.", "Also, the fixed methods also are a waste of limited network resources.", "There are no known methods which provide selectivity on a host basis to force some hosts to be use the tunnel exclusively in a compulsory mode and others to use the split tunnel while coexisting on the same LAN.", "Described herein is a method of substituting network addressing elements with predefined information, thereby managing the flow of network traffic as it seeks egress to an alternate network, comprising: presenting an interface for intercepting a reply to a devices-DHCP request; substituting the reply with predefined information; and enabling a split-tunnel; substituting an IP address of an issuing DHCP server with an IP address of a local terminal; and forwarding resulting traffic on from the local terminal to a predetermined interface based on a destination of that address.", "Also described is a computer software product for use with a computer, said computer software product comprising, and a module constructed and arranged to be embedded into a computer program, wherein the module is operable to provide substitution addressing elements to a DHCP-requesting device.", "Another embodiment of the present invention is a computer-readable storage medium storing an executable computer program module for enabling substituting network addressing elements, the module comprising: an intercept sub-module configured to manage DHCP information between networks; an elements sub-module configured to obtain and establish the network items to be substituted; and a substitution sub-module configured to perform the operations of deconstructing, substituting, and rebuilding packets with predefined information, thereby allowing the module to manage the flow of network traffic as it seeks egress to an alternate network.", "Yet another embodiment of the present invention is a method to permit split-routing to occur without any changes, modifications or configuration of a requesting host, network stack, network architecture, and routing and forwarding behavior, the method comprising: presenting a module to intercept the normal and standard DHCP communication between a requesting device and a DHCP server, wherein the module is configured for substituting the elements within the server response with the module's own elements, thereby directing traffic through an alternate route.", "The summary is an overview of the concept in a simplified form and not intended to identify essential features of the claimed subject matter, nor is it necessarily intended to be used as an aid in determining the scope of the claimed subject matter.", "BRIEF DESCRIPTION OF THE DRAWINGS The detailed description is described with reference to the accompanying drawings.", "In the drawings, the left-most digit of a reference number identifies the figure to which the reference number first appears.", "FIG.", "1 shows an example communication environment in which the present invention can be implemented; FIG.", "2 shows an exemplary overview of behavior of a network-attached device on a local network (i.e., a non-tunnel network).", "FIG.", "3 shows an exemplary overview of behavior of network-attached devices when a compulsory VPN is activated.", "FIG.", "4 an overview of the Module of the present invention and sub-modules.", "FIG.", "5 shows and exemplary overview of one embodiment of the Module of the present invention, the flow of steps and the flow of traffic.", "FIG.", "6 shows an exemplary overview of network-attached devices operating using one embodiment of the present invention that includes a Remote Module.", "FIG.", "7 shows an exemplary overview of network attached devices operating using one embodiment of the present invention that includes a Direct Tunnel Module.", "DETAILED DESCRIPTION A network based device needs to have certain mandatory addressing and connectivity information in order to communicate on any network.", "On a local area network (LAN) this device will send out a query asking for this network connectivity information.", "A server on the LAN will respond with this information which is local to this LAN.", "In all cases, this addressing and connectivity information assumes that the network based device is local and would behave as a local device.", "In situations where a compulsory (all traffic if forced) tunnel VPN or Tunnel is installed all of the remote network traffic from remote devices is sent to the headquarters network.", "When a network based device needs it connectivity information in this environment it will receive its addressing and connectivity query response —not from the local server—but the remote server at the headquarters.", "As such all network traffic from the remote site will traverse the tunnel even traffic not destined for use or processing by that network (compulsory tunneling).", "In many cases it is desired to have only the network traffic for the remote network traverse the tunnel whilst all non-remote network traffic (local traffic) automatically traverse via its local network connection.", "This is often called a split-tunnel where there are two different paths for flows to traverse.", "The present invention is designed to automatically enforce the split-tunnel behavior on networks with multiple DHCP servers.", "In order to have specified devices (indicated in a list of specified devices in the process) or all devices on a network, at any time, be able to use this split-tunnel, the connectivity certain parameters must be modified prior to delivery to that host so that the desired information received by the device ensures its proper behavior of either compulsory or split-tunnel behavior.", "When a VPN or Tunnel is installed a hosts' connectivity query will traverse the compulsory tunnel to the headend LAN.", "A server on this LAN will respond with connectivity information towards the querying remote host/devices for its local headend network.", "The invention will automatically substitute the appropriate parameters so that the querying host's behavior will automatically use the tunnel for remote traffic and the split-tunnel for non-remote network traffic.", "The present invention does not require modification to the headend LAN server, the remote network, or the queried host/device.", "Existing methods known in the art require setup of multiple LAN servers and/or routers (network elements) each with their own connectivity information or modification to the hosts to make use of split-tunnel.", "There is no known automatic method for having a single automatic address scheme across multiple networks and/or multiple gateways.", "Also, the fixed methods also are a waste of limited network resources.", "There not known methods which provide selectivity on a host basis to force some hosts to be use the tunnel exclusively in a compulsory mode and others to use the split tunnel while coexisting on the same LAN (layer-2 environment.}", "Definitions The following terms are used to describe different aspects of the invention and the environment in which the invention operates.", "These terms are used for explanation purposes only and are not intended to limit the scope for any aspect of the invention.", "IP refers to Internet Protocol used for network communications.", "IP Address refers to the unique address issued to hosts, devices applications and used for bi-direction or unidirectional communications between those hosts, devices, or applications.", "Device or devices refer to any host, device or application that uses or makes use of IP for communications.", "End-point device or devices refer to some application or device that provides the ability to begin or end a tunnel.", "Tunnel refers to the transparent bridged link between networks as provided by software.", "A bridged-link creates a single logical network although not physically co-located.", "Module refers to one particular embodiment of the invention, which refers to computer program logic for providing a specified functionality.", "One or more variations of the Module can be implemented in hardware, firmware, and/or software.", "The module is typically stored on a computer-readable storage medium such as the storage device, loaded into memory, and executed by a processor.", "Modules are referred to herein as S1, S2, S3, S4, S5, and the nomenclature is for illustrative purposes; other identification means could be assigned to the various Modules, such as M1, M2, and the like.", "An interface refers to a point of logical or logical/physical connection.", "Typically, the term interface is used in reference to an Ethernet or Ethernet-like port.", "This reference assumes that the interface structures present an IP-based behavior posture.", "A predetermined interface refers to either an automatic or manual configuration of the invention process to supply the desired information to the requesting host so that its traffic goes out the desired interface based on the traffic type offered.", "A packet refers to binary data capable of being routed through a computer network.", "To improve communication performance and reliability, each message sent between two network devices is often subdivided into packets by the underlying hardware and software.", "Illustrative Network Environment The present invention works within a typical network configuration and operationally performs the task of substituting a default router from an issuing DHCP server with an IP address of a local terminal.", "This allows the local terminal to forward outgoing traffic to a specific interlace (Internet or tunnel) based on the destination of the address.", "Consider the following typical network drawing shown in FIG.", "1, where each network is independent with its own DHCP server on its network.", "As used in this description, a device may take a variety of forms including, but not limited to, computing devices, mobile phones such as smart phones, tablet, desktop and laptop computers, media devices or any application or source operating on a processor such as mobile-phone application or various other applications as would be appreciated by those skilled in the art.", "On each network, when a device attaches it will issue a DHCP request.", "If present, a DHCP server will respond with various network connectivity-information for the device.", "The basic information required for network connectivity include: an IP address and netmask; one or more DNS addresses; and a default gateway.", "When a Tunnel is initiated it will request a DHCP address from the local network from where it is attached.", "For example, based on FIG.", "1, Device 8 will obtain DHCP information from DHCP server 1; Device 9 will obtain DHCP information from DHCP server 7.When a tunnel is created between the end-point devices 8 and 9 the attached Device 10 obtains its address from the native network DHCP server (Device 7) with the information for its network.", "Therefore, it may be desirable for some Device 10 users traffic not destined for the native network—via the tunnel—to simply egress the local router (Device 3) normally.", "But the DHCP information offered over the tunnel would force all Device 10's traffic to traverse the tunnel and egress via the native network's router {Device 6).", "Therefore, in many instances, the traffic flow from Device 10 would normally be presented to network 2, and only to use the tunnel for traffic destined to network 6.Employing the invention as described herein, Device 8 would intercept the DHCP communication destined for DHCP server 7, and substitute the proper network elements to facilitate the split-tunnel operation.", "Networks represent any type of communication network, including wire-based (i.e., fiber optic, cable, etc.", "), wireless (i.e., cellular, WiFi, Bluetooth, etc) or combinations thereof.", "Hosts represent any type of client or server computing device on the network.", "Each host may be configured to send and receive data.", "A host may be a dedicated server or router through which incoming or outgoing messages are routed on behalf of a client device, user, or application and use any suitable addressing protocol or layer.", "A server generally represents a name server that hosts a network service such as providing response to queries against a directory service.", "This may include addressing components such as IP addresses, amongst others as would be recognized by one skilled in the art.", "Hosts and server also represent any suitable computing device, which includes one or more processors and the ability to access a computer-readable media.", "Processors interact with computer-readable media to execute instructions that facilitate functionality of each router or server.", "Processors may be distributed in more than one computer system and over a network.", "Computer readable media may include any suitable computer-storage media including volatile and non-volatile memory, removable and non-removable media and any combination thereof.", "In another embodiment, computer readable media may include communication media that may embody computer readable instructions, data structures, program modules, or other data in a modulated data signal.", "Standard/Typical Behavior of Network Attached Devices on a Local Network FIG.", "2 shows a typical network when a device seeks to access the Internet.", "Within the operating firmware of a device or application there will be several functions attempting to establish the device on the network.", "In order to establish a device on the network the industry has standardized on the DHCP protocol to provide device/application connectivity information.", "Once a device has the basic information of a unique IP address, netmask, and at least one DNS address it can completely access any other Internet address anywhere in the world.", "The networking and computing industry has standardized on DHCP as the preferred method for distributing connectivity information to devices which require and ask for this network connectivity information.", "When a device wishes to establish network connectivity its firmware will transmit to an available connection (either physical or logical) a DHCP disc very request.", "As the device does not yet have any network information it sends this out as a broadcast to any listening DHCP server.", "A DHCP server is a preconfigured network service existing on the local network.", "As it is setup for the local network, any devices requesting this connectivity information will receive the appropriate information to properly function.", "After the device is connected, or has its connectivity information, the applications are free to communicate with the Internet via local resources and services.", "Network-based services are used to support devices, applications, etc.", "These services are accessed via a physical or logical connection point, however these services may be found all on a single machine.", "The arrangement does not affect operation.", "Standard/Typical Behavior of Network Attached Devices when a Compulsory VPN is Activated FIG.", "3 shows a network where a compulsory VPN is implemented ALL traffic is forced to the non-native network.", "Thus, any devices/applications will communicate with the network services—not locally—but through the VPN.", "Additionally, all network based application traffic will traverse over the VPN even for traffic not required or destined for the non-native network.", "Network Behavior Employing the Exemplary Module When using the Exemplary Module, traffic ONLY destined for the non-native network will traverse the tunnel.", "This is called a split-tunnel.", "The key advantage of the Exemplary Module is that the Module can operate automatically without pre configuration.", "FIG.", "4 shows an overview of the Module 400 and sub-modules.", "In one embodiment, Module 400 comprises various elements (sub-modules), designated S1, S2 and S3.In one embodiment, S1 {Intercept sub-module 402) comprises an intercept sub-module configured to manage the DHCP information between networks.", "In another embodiment, S2 (Elements sub-module 404) comprises a substitution elements sub-module configured to obtain and establish the network items to be substituted.", "In one embodiment, this sub-module may be configured to obtain these either statically (e.g., manually configured) or dynamically through pre-fetching from the DHCP server.", "In another embodiment, remote configuration of the S2 Elements sub-module, via a Remote Module, is described further herein.", "In yet another embodiment, S3 (Substitution sub-module 406) comprises a substitution sub-module configured to perform the operations of deconstructing, substituting, and rebuilding the packets.", "FIG.", "5 shows an exemplary Module's configuration elements, and shows the traffic patterns for both the connectivity enquiry and the automatic traffic to both native or non-native resources (See FIG.", "Legend).", "The Module's configuration elements contain the substitution elements to be provided to the device.", "These elements can be pre-configured, automatically learned, or a combination of both, as described further below.", "Depending on the implementation and form of distribution, the configuration of the module can be performed in different ways (for example: by setting properties of an embeddable component, by writing or modifying source code, by writing or modifying one or more configuration files, etc).", "Some or all of the configuration parameters may also be preset in the module, bundled with the module or hard-coded into the module.", "In one embodiment, the module resides on a computing device which processes incoming and outgoing network messages as an application, firmware, or software.", "The module and sub-module assemblies are used at different phases of the communications cycle and operate when those phases are initiated or operated by the network messaging.", "Remote Query of Pre-Defined Information Via Remote Module In another embodiment, predefined information can be queried in a database for retrieval as needed.", "This operation is carried out by way of a Remote Module 600, shown as S4 in FIG.", "6.The Remote Module 600 provides remote or centralized automatic query for acquisition of elements.", "Remote Module 600 places information for later retrieval, or query for information it may use for its own operation.", "In one embodiment, Remote Module 600 uses the Domain Name System (DNS) system TXT data type to create a message based bi-directional communication system.", "The DNS system allows for the retrieval of network information in a recursive manner attempting to resolve a queried host name.", "The DNS request (for any data type) can and will traverse through multiple random servers until it gets to the DNS server that is authoritative for that domain.", "Once that authoritative DNS server is found it attempt to honor the request with the stored information from its database.", "Remote Module codes various host names within a domain via a structure and places an associated TXT record also encoded with the desired information.", "For a remote fielded device to obtain information it is seeking it merely issues a standard DNS TXT record request for a coded-host name full-qualified-domain.", "The request, if available, will be delivered by the authoritative DNS server back to the querying device.", "Additionally, the DNS system can be used to create a standard DNS NSUPDATE record to permit the remote addition or modification of data, in real time, from a remote device.", "The inherent nature of DNS, and its recursion, is a key benefit of the connectionless communications path.", "The module leverages this to provide a connectionless peer-to-peer or peer-to-many information management front-end.", "Example A device in city X configured with a Remote Module S4—with Remote Module in the “on” position.", "The device will obtain it's public IP address on its main interface (not module specific) The device will then create a DNS NSUPDATE record to a user specified domain—this is example.com—to push the learned knowledge of what it has just learned—it's public IP.", "The update will send the devices Ethernet MAC address plus an pre-pend as the HOST part (pip.xx-xx-xx-xx-xx-xx.example.net) with the INFO text record data as“<publicIP.y.y.y.y>” Any other device anywhere looking to contact this specific unit can use the same DNS system and simply ask for the INFO record of pip.xx-xx-xx-xx-xx-xx.example.net for which will be returned <publicIP.y.y.y.y>.", "An unlimited of host pre-pends and INFO text record formats can used to allow for direct addressing of such things (but not limited to) as DHCP hosts, DHCP gateways, System Uptime Status, Firmware updates, or logging.", "Thus, also envisioned in the present invention—by way of Remote Module 600—is a method for indirect connectionless bi-directional messaging over unknown network infrastructures.", "Where the method communicates with a database without the requirement for direct access to that database for either obtaining or placing information; and where the communications can contain an unlimited amount of discreet and selectable information elements; and where there is no direct acknowledgement of receipt of communications.", "In one embodiment, the method codes discreet information elements as host names within a full-qualified-domain-name places an associated TXT record also encoded with the desired information; where remote device to obtain information it is seeking it merely issues a standard DNS TXT record request to any DNS server for a coded-host name full-qualified-domain; where the request will be delivered by the authoritative DNS server back to the querying device thorough one or more DNS servers.", "In another embodiment, the method can be used to create a standard DNS NSUPDATE record to permit the remote addition or modification of data, in real time, from a remote device.", "Alternate Embodiment for Establishing Tunnel to Non-Native Network When a host is installed on the network there are situations where it will desire to communicate directly with another peer across that network.", "The network infrastructure may not permit this direct communication through a variety of known and/or unknown limitations.", "Often these limitations are out of the control of the each host's network providers.", "This situation is particularly difficult when creating a virtual private network (VPN) tunnel between sites as NAT or Firewall gateways are free to make outbound connections but block any ad-hoc in-bound connections.", "Thus, also envisioned in the present invention is a Direct Tunnel Module 700, shown as S5 in FIG.", "7.The Direct Tunnel Module 700 permits one or more network devices to automatically discover capabilities for communications directly between associated end-points across one or more unknown networks even if both end points are behind a NAT or Firewall.", "It is important to note that Remote Module 700 does not require a relay or a special protocol for tunneling and can be used with standard or proprietary tunneling methods.", "When two VPN network device wish to establish a direct peer-to-peer connection for the purpose of tunnel connectivity it is necessary that one endpoint receives the initial setup request from end-point towards its peer-endpoint.", "Often this is referred as client and server communications with the initiating device is the client and the receiving device is the server.", "Most networks operate with a Network Address Translator (NAT) and create a private IP address network for its hosts.", "For an endpoint initiating an outbound network connection, meaning the message traverses the private network toward the public IP through the NAT, communications are unimpeded.", "When a public-to-private connection is to be initially established a NAT router will block this connection as it does not recognize the connection or which host on the private network it should send it to.", "In one embodiment, when Direct Tunnel Module 700 is operating within two separate peer-devices, each device will initially and individually contact an offsite management server that can proxy the information between the two endpoints.", "They will exchange capabilities and information and begin a sequence of agreed upon outbound connections.", "The endpoint with the lower Ethernet MAC address will become the server with its peer the client.", "Each device will establish a sequence connection towards each other until one connection is discovered sufficient to establish direct endpoint-to-endpoint connectivity.", "At this point, the VPN or Tunnel can be initiated with the underlying networking transport already established.", "In another embodiment, Direct Tunnel Module 700 facilitates the automatic creation of bi-directional direct peer-to-peer network connections through Internet Protocol based network address translators.", "In yet another embodiment, Module 700 provides a method that permits one or more devices to automatically discover capabilities for communications directly between associated end-points across one or more unknown networks even if both end points are behind a NAT or Firewall, wherein the method does not require a server or relay function outside of each device network or a special protocol for the creation of a VPN, tunneling, or any other application.", "Module 700 is further configured so that each device will generate identity communications to a separate database; and each device will create multiple outbound communications sessions; and each device will report to the separate database the status and information of the initiated sessions; and each device will attempt connections on all of the sessions.", "A successful connection response will generate a handoff in each device to the requesting application.", "Reference herein to “example”, “embodiments” or similar formulations means that a particular feature, structure, operation or characteristic described in connection with the example, is included in at least one implementation in this description.", "Thus, the appearance of such phrases or formulations herein is not necessarily all referring to the same example.", "Further, various particular features, structures, operations or characteristics may be combined in any suitable manner in one or more examples, and or embodiments." ] ]
Patent_15875978
[ [ "CEILING PANEL ASSEMBLY AND MOUNTING SYSTEM THEREFOR", "A module for mounting within a ceiling panel assembly.", "The module includes an upper mounting frame that includes a main body portion that defines a central opening, a lower mounting frame that is at least partially received in the central opening of the upper mounting frame, and a latch assembly.", "The main body portion of the upper mounting frame includes a flange extending outwardly therefrom.", "The lower mounting frame is pivotable with respect to the upper mounting frame between a first position and a second position.", "The latch assembly is associated with a first end of the upper mounting frame and the lower mounting frame.", "When the latch assembly is released the lower mounting frame pivots from the first position to the second position." ], [ "1.A module for mounting within a ceiling panel assembly, the module comprising: an upper mounting frame that includes a main body portion that includes an inner surface that defines a central opening having a central opening axis, wherein the main body portion includes a flange extending outwardly therefrom, wherein the flange extends outwardly from and approximately perpendicular to the central opening axis such that when the module is mounted in a ceiling panel assembly a bottom surface of the flange is parallel to a top surface of the ceiling panel assembly, and wherein the upper mounting frame includes opposing first and second ends, and opposing first and second sides, a lower mounting frame that is at least partially received in the central opening of the upper mounting frame, wherein the lower mounting frame includes a first end and a second end, wherein the lower mounting frame is pivotable about a pivot point with respect to the upper mounting frame between a first position and a second position, wherein the pivot point is located closer to the second end than the first end, wherein one the upper mounting frame includes at least one upper curved hinge member extending therefrom, wherein the lower mounting frame includes at least one lower curved hinge member that is engaged with the upper curved hinge member, such that the lower mounting frame can pivot with respect to the upper mounting frame, and a latch assembly that is associated with the first end of the upper mounting frame and the lower mounting frame, wherein when the latch assembly is released the lower mounting frame pivots from the first position to the second position, wherein the latch assembly includes a latch member that is mounted within a protrusion on the upper mounting frame and a ledge that is disposed on the lower mounting frame, wherein the protrusion defines a latch pocket in which an engagement surface on the latch member is positioned, and wherein the engagement surface is accessible via an opening defined in the protrusion.", "2.The module of claim 1 wherein a stationary portion of the latch member is received in a receiver opening, and wherein the receiver opening is separated from the latch pocket by a divider.", "3.The module of claim 1 further comprising a bezel that includes tabs extending upwardly therefrom, wherein the tabs are received in channels defined in the upper mounting frame.", "4.The module of claim 1 wherein the flange of the upper mounting frame includes at least one electrical connection cylinder extending upwardly from an upper surface thereof.", "5.The module of claim 1 wherein a component is mounted in the lower mounting frame, wherein the component is at least one of an oxygen mask, a speaker, a smoke detector, an air extractor or a light, and wherein the component is pivotable together with the lower mounting frame between the first position and the second position.", "6.The module of claim 1 further comprising a second latch assembly that is associated with the first end of the upper mounting frame and the lower mounting frame, wherein when both the latch assembly and the second latch assembly are released the lower mounting frame pivots from the first position to the second position, wherein the second latch assembly includes a second latch member that is mounted within a second protrusion on the upper mounting frame and a second ledge that is disposed on the lower mounting frame, wherein the second protrusion defines a second latch pocket in which a second engagement surface on the second latch member is positioned, and wherein the second engagement surface is accessible via a second opening defined in the second protrusion." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Commercial aircraft, such as the Airbus A320 or Boeing 737, are typically constructed from modular components, the size, weight and construction of which are dictated by many considerations, including fuselage dimensions, aesthetic and safety.", "Many of these requirements are imposed by law or regulation.", "Aircraft components, such as overhead stowage compartments, seats, lavatories, galleys, lighting systems, etc.", "are all required to function within strictly confined spaces.", "Manufacturers of aircraft are constantly refining interior aircraft designs to achieve more comfort and utility for passengers and crew within carrier-imposed restraints on cost, weight, maintenance down-time, and safety.", "Commercial passenger aircraft generally include lavatories for use by passengers and crew that include a ceiling that may have components such as a light, smoke detector and or speaker therein.", "Typically, each of the components is individually mounted in its own unique way in the ceiling panel.", "They each require a different set of hardware, different set of fasteners and inserts.", "Therefore, the look, is not uniform." ], [ "<SOH> SUMMARY OF THE PREFERRED EMBODIMENTS <EOH>In accordance with a first aspect of the present invention there is provided a module for mounting within a ceiling panel assembly.", "The module includes an upper mounting frame that includes a main body portion that defines a central opening, a lower mounting frame that is at least partially received in the central opening of the upper mounting frame, and a latch assembly.", "The main body portion of the upper mounting frame includes a flange extending outwardly therefrom.", "The lower mounting frame is pivotable with respect to the upper mounting frame between a first position and a second position.", "The latch assembly is associated with a first end of the upper mounting frame and the lower mounting frame.", "When the latch assembly is released the lower mounting frame pivots from the first position to the second position.", "In a preferred embodiment, one of the upper mounting frame and lower mounting frame includes two pivot pins extending inwardly therefrom and the other of the upper mounting frame and the lower mounting frame includes two pivot openings defined therein.", "The pivot pins are received in the pivot openings.", "Preferably, the pivot openings comprise a pivot slot that is open to an outside of the upper mounting frame or the lower mounting frame.", "In a preferred embodiment, the pivot pins extend inwardly from the main body portion of the upper mounting frame into the central opening and the pivot openings are defined in the lower mounting frame.", "In a preferred embodiment, the latch assembly includes a latch member that is mounted on one of the lower mounting frame or the upper mounting frame and a ledge that is disposed on the other of the lower mounting frame or the upper mounting frame.", "Preferably, the latch member is mounted within a protrusion on the upper mounting frame.", "The protrusion defines a latch pocket in which an engagement surface on the latch member is positioned.", "The engagement surface is accessible via an opening defined in the protrusion.", "Preferably, a stationary portion of the latch member is received in a receiver opening that is separated from the latch pocket by a divider.", "In a preferred embodiment, the module also includes a bezel that includes tabs extending upwardly therefrom.", "The tabs are received in channels defined in the upper mounting frame.", "Preferably, the first end of the lower mounting frame includes alignment tabs extending therefrom that are received in alignment openings defined in the upper mounting frame and the upper mounting frame includes at least one electrical connection cylinder extending upwardly from an upper surface thereof.", "In another preferred embodiment, the upper mounting frame and lower mounting frame include complementary curved hinge members disposed on the second ends thereof.", "In a preferred embodiment, the module includes a component that is mounted in the lower mounting frame.", "The component is at least one of an oxygen mask, a speaker, a smoke detector, an air extractor or a light and the component is pivotable together with the lower mounting frame between the first position and the second position.", "In accordance with another aspect of the present invention there is provided a module for mounting within a ceiling panel assembly that includes an upper mounting frame and a lower mounting frame.", "The upper mounting frame includes a main body portion that defines a central opening.", "The main body portion includes a flange extending outwardly therefrom and the upper mounting frame includes a first end and a second end.", "Two pivot pins extending inwardly from the main body portion into the central opening and a latch member is mounted within a protrusion on the first end of the upper mounting frame.", "The lower mounting frame is at least partially received in the central opening of the upper mounting frame and includes a first end and a second end.", "The first end includes a ledge that is engaged with the latch member of the upper mounting frame.", "The lower mounting frame includes two pivot openings defined therein that are communicated with pivot slots that are open to an outside of the lower mounting frame, and the pivot pins are received in the pivot openings.", "The lower mounting frame is pivotable with respect to the upper mounting frame between a first position and a second position.", "In accordance with another aspect of the present invention there is provided a lower mounting frame for use with a mounting system that includes an upper mounting frame.", "The lower mounting frame includes a main body portion that includes first, second, third and fourth sides, a bottom surface and a top edge, a ledge that is positioned on the first side of the main body portion, and first and second pivot slots defined in the third and fourth sides of the main body portion.", "The first and second pivot slots each have a first portion that extends generally parallel to the bottom surface of the main body portion and a second portion that angles upwardly from the first portion and is open to the top edge of the main body portion.", "Preferably, the lower mounting frame includes alignment tabs extending upwardly therefrom that are adapted to be received in alignment openings defined in the upper mounting frame.", "In a preferred embodiment, the bottom surface of the main body portion includes at least one of an opening for receiving a grill, a speaker grill or a light cover.", "The present invention provides a generally uniform system that allows the mounting of different components of different sizes.", "For example, in the commercial aircraft industry there are a number of different speakers that are typically used.", "The present invention allows all of these speakers to be mounted, where before there were three different mounting styles for each speaker.", "In the present invention, each of the components can be removed individually.", "Each component has its own pivot and latching system, which is beneficial for maintenance.", "It also allows for different looks.", "A bezel can be used if desired." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "15/011,215, filed Jan. 29, 2016, which claims the benefit of U.S.", "Provisional Application No.", "62/110,380, filed Jan. 30, 2015, the entireties of which are incorporated by reference herein.", "FIELD OF THE INVENTION The present invention relates generally to a ceiling module, and more particularly to a ceiling module for use with a lavatory in an aircraft.", "BACKGROUND OF THE INVENTION Commercial aircraft, such as the Airbus A320 or Boeing 737, are typically constructed from modular components, the size, weight and construction of which are dictated by many considerations, including fuselage dimensions, aesthetic and safety.", "Many of these requirements are imposed by law or regulation.", "Aircraft components, such as overhead stowage compartments, seats, lavatories, galleys, lighting systems, etc.", "are all required to function within strictly confined spaces.", "Manufacturers of aircraft are constantly refining interior aircraft designs to achieve more comfort and utility for passengers and crew within carrier-imposed restraints on cost, weight, maintenance down-time, and safety.", "Commercial passenger aircraft generally include lavatories for use by passengers and crew that include a ceiling that may have components such as a light, smoke detector and or speaker therein.", "Typically, each of the components is individually mounted in its own unique way in the ceiling panel.", "They each require a different set of hardware, different set of fasteners and inserts.", "Therefore, the look, is not uniform.", "SUMMARY OF THE PREFERRED EMBODIMENTS In accordance with a first aspect of the present invention there is provided a module for mounting within a ceiling panel assembly.", "The module includes an upper mounting frame that includes a main body portion that defines a central opening, a lower mounting frame that is at least partially received in the central opening of the upper mounting frame, and a latch assembly.", "The main body portion of the upper mounting frame includes a flange extending outwardly therefrom.", "The lower mounting frame is pivotable with respect to the upper mounting frame between a first position and a second position.", "The latch assembly is associated with a first end of the upper mounting frame and the lower mounting frame.", "When the latch assembly is released the lower mounting frame pivots from the first position to the second position.", "In a preferred embodiment, one of the upper mounting frame and lower mounting frame includes two pivot pins extending inwardly therefrom and the other of the upper mounting frame and the lower mounting frame includes two pivot openings defined therein.", "The pivot pins are received in the pivot openings.", "Preferably, the pivot openings comprise a pivot slot that is open to an outside of the upper mounting frame or the lower mounting frame.", "In a preferred embodiment, the pivot pins extend inwardly from the main body portion of the upper mounting frame into the central opening and the pivot openings are defined in the lower mounting frame.", "In a preferred embodiment, the latch assembly includes a latch member that is mounted on one of the lower mounting frame or the upper mounting frame and a ledge that is disposed on the other of the lower mounting frame or the upper mounting frame.", "Preferably, the latch member is mounted within a protrusion on the upper mounting frame.", "The protrusion defines a latch pocket in which an engagement surface on the latch member is positioned.", "The engagement surface is accessible via an opening defined in the protrusion.", "Preferably, a stationary portion of the latch member is received in a receiver opening that is separated from the latch pocket by a divider.", "In a preferred embodiment, the module also includes a bezel that includes tabs extending upwardly therefrom.", "The tabs are received in channels defined in the upper mounting frame.", "Preferably, the first end of the lower mounting frame includes alignment tabs extending therefrom that are received in alignment openings defined in the upper mounting frame and the upper mounting frame includes at least one electrical connection cylinder extending upwardly from an upper surface thereof.", "In another preferred embodiment, the upper mounting frame and lower mounting frame include complementary curved hinge members disposed on the second ends thereof.", "In a preferred embodiment, the module includes a component that is mounted in the lower mounting frame.", "The component is at least one of an oxygen mask, a speaker, a smoke detector, an air extractor or a light and the component is pivotable together with the lower mounting frame between the first position and the second position.", "In accordance with another aspect of the present invention there is provided a module for mounting within a ceiling panel assembly that includes an upper mounting frame and a lower mounting frame.", "The upper mounting frame includes a main body portion that defines a central opening.", "The main body portion includes a flange extending outwardly therefrom and the upper mounting frame includes a first end and a second end.", "Two pivot pins extending inwardly from the main body portion into the central opening and a latch member is mounted within a protrusion on the first end of the upper mounting frame.", "The lower mounting frame is at least partially received in the central opening of the upper mounting frame and includes a first end and a second end.", "The first end includes a ledge that is engaged with the latch member of the upper mounting frame.", "The lower mounting frame includes two pivot openings defined therein that are communicated with pivot slots that are open to an outside of the lower mounting frame, and the pivot pins are received in the pivot openings.", "The lower mounting frame is pivotable with respect to the upper mounting frame between a first position and a second position.", "In accordance with another aspect of the present invention there is provided a lower mounting frame for use with a mounting system that includes an upper mounting frame.", "The lower mounting frame includes a main body portion that includes first, second, third and fourth sides, a bottom surface and a top edge, a ledge that is positioned on the first side of the main body portion, and first and second pivot slots defined in the third and fourth sides of the main body portion.", "The first and second pivot slots each have a first portion that extends generally parallel to the bottom surface of the main body portion and a second portion that angles upwardly from the first portion and is open to the top edge of the main body portion.", "Preferably, the lower mounting frame includes alignment tabs extending upwardly therefrom that are adapted to be received in alignment openings defined in the upper mounting frame.", "In a preferred embodiment, the bottom surface of the main body portion includes at least one of an opening for receiving a grill, a speaker grill or a light cover.", "The present invention provides a generally uniform system that allows the mounting of different components of different sizes.", "For example, in the commercial aircraft industry there are a number of different speakers that are typically used.", "The present invention allows all of these speakers to be mounted, where before there were three different mounting styles for each speaker.", "In the present invention, each of the components can be removed individually.", "Each component has its own pivot and latching system, which is beneficial for maintenance.", "It also allows for different looks.", "A bezel can be used if desired.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a front perspective view of ceiling module in accordance with a preferred embodiment of the present invention; FIG.", "2 is a rear perspective view of the ceiling module of FIG.", "1; FIG.", "3 is a front exploded perspective view of the ceiling module of FIG.", "1; FIG.", "4 is a rear exploded perspective view of the ceiling module of FIG.", "1; FIG.", "5A is a cross-sectional side elevational view showing the lower mounting frame being connected to the upper mounting frame; FIG.", "5B is a cross-sectional side elevational view showing the lower mounting frame pivoting from the second position (the maintenance position) to the first position (the operation position); FIG.", "6 is an exploded view of the air extractor module; FIG.", "7 is an exploded view of the oxygen module; FIG.", "8 is an exploded view of the speaker module; FIG.", "9 is an exploded view of the light module; and FIG.", "10 is a perspective view showing the ceiling module of FIG.", "1 used in an aircraft lavatory.", "Like numerals refer to like parts throughout the several views of the drawings.", "DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The following description and drawings are illustrative and are not to be construed as limiting.", "Numerous specific details are described to provide a thorough understanding of the disclosure.", "However, in certain instances, well-known or conventional details are not described in order to avoid obscuring the description.", "References to one or an embodiment in the present disclosure can be, but not necessarily are references to the same embodiment; and, such references mean at least one of the embodiments.", "Reference in this specification to “one embodiment” or “an embodiment” means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment of the-disclosure.", "The appearances of the phrase “in one embodiment” in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments.", "Moreover, various features are described which may be exhibited by some embodiments and not by others.", "Similarly, various requirements are described which may be requirements for some embodiments but not other embodiments.", "The terms used in this specification generally have their ordinary meanings in the art, within the context of the disclosure, and in the specific context where each term is used.", "Certain terms that are used to describe the disclosure are discussed below, or elsewhere in the specification, to provide additional guidance to the practitioner regarding the description of the disclosure.", "For convenience, certain terms may be highlighted, for example using italics and/or quotation marks: The use of highlighting has no influence on the scope and meaning of a term; the scope and meaning of a term is the same, in the same context, whether or not it is highlighted.", "It will be appreciated that the same thing can be said in more than one way.", "Consequently, alternative language and synonyms may be used for any one or more of the terms discussed herein.", "No special significance is to be placed upon whether or not a term is elaborated or discussed herein.", "Synonyms for certain terms are provided.", "A recital of one or more synonyms does not exclude the use of other synonyms.", "The use of examples anywhere in this specification including examples of any terms discussed herein is illustrative only, and is not intended to further limit the scope and meaning of the disclosure or of any exemplified term.", "Likewise, the disclosure is not limited to various embodiments given in this specification.", "Without intent to further limit the scope of the disclosure, examples of instruments, apparatus, methods and their related results according to the embodiments of the present disclosure are given below.", "Note that titles or subtitles may be used in the examples for convenience of a reader, which in no way should limit the scope of the disclosure.", "Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure pertains.", "In the case of conflict, the present document, including definitions, will control.", "It will be appreciated that terms such as “front,” “back,” “top,” “bottom,” “side,” “short,” “long,” “up,” “down,” “aft,” “forward,” “inboard,” “outboard” and “below” used herein are merely for ease of description and refer to the orientation of the components as shown in the figures.", "It should be understood that any orientation of the components described herein is within the scope of the present invention.", "FIGS.", "1-10 show a ceiling module or ceiling panel assembly 10 in accordance with a preferred embodiment of the present invention.", "In an exemplary embodiment, the ceiling module can be used in a modular aircraft lavatory, such as the one taught in U.S. Patent Publication No.", "2014/0196206, published on Jul.", "17, 2014, the entirety of which is incorporated by reference herein in its entirety.", "However, this is not a limitation and the ceiling module can be used elsewhere.", "As shown in FIGS.", "1-2, in a preferred embodiment, the ceiling panel assembly 10 generally includes a panel 12 and a plurality of modular components that each include a similar mounting system for mounting the component in the panel 12.It will be appreciated that the number and types of components are not limiting on the present invention.", "However, for exemplary purposes only, the drawings show an air extractor module 14, a speaker module 16, a light module 18 and an oxygen module 20.The system can be used to mount other components, such as smoke detectors, personal service units, flight attendant call and other buttons, etc.", "As shown in FIGS.", "3-4, each module includes a lower mounting frame 22 and an upper mounting frame 24.The lower and upper mounting frames 22 and 24 for each component are sized and shaped differently, but each of the lower and upper mounting frames 22 and 24 work together to provide a system to mount the component within the panel 12.In a preferred embodiment, one or more of the modules also includes a bezel 26 that mates with and mounts on the upper mounting frame 24 (or the lower mounting frame 22).", "The bezel 26 can be included or excluded depending on the desired look of the ceiling panel assembly 10.To receive the individual modules, the panel 12 includes an air extractor module opening 14a, a speaker module opening 16a, a light module opening 18a and an oxygen module opening 20a.", "The openings also include cutouts for any protrusions on the upper mounting frame 24.As shown in FIGS.", "3-9, the upper mounting frames 24 each include a main body portion 30 that is sized to be received in the opening in the panel 12 and includes a central opening 31 and a flange 32 that extends outwardly therefrom.", "The flange 32 includes a bottom surface 32a that rests against the top surface of the ceiling panel 12 and is typically bonded thereto.", "The individual components (air extractor, light, speaker, etc.)", "are mounted or connected to the lower mounting frame 22.As will described below, the lower mounting frame 22 for each component may be different.", "However, each of the lower mounting frames 22 have similar features that allow the lower mounting frames 22 to hingedly connect and be latched to the upper mounting frames 24.The lower mounting frame 22 is sized to be at least partially received in the central opening 31 (i.e., it has a smaller width and length dimension than the upper mounting frame 24).", "The lower and upper mounting frames 22 and 24 include a first end that includes a latch assembly 34 and a second end that includes a pivot or hinge assembly 36.Any type of latch assembly that allows the lower mounting frame 22 to latch to the upper mounting frame 24 is within the scope of the present invention.", "Furthermore, any type of pivot assembly that allows the lower mounting frame 22 (and the component therein) to pivot with respect to the upper mounting frame 24 between a first position (where it is latched in place and operational) and a second position (where it is hinged downwardly for maintenance or removal) is within the scope of the present invention.", "As shown in FIGS.", "5A-5B, in a preferred embodiment, the latch assembly 34 includes a pivotable latch member 38 on the upper mounting frame 24 and a ledge 40 that is captured by the latch member 38 on the lower mounting frame 22.The latch member 38 includes a stationary portion 41 that is received in a receiver opening 42 and a latch portion 43 that is received in a latch pocket 44.The latch pocket 44 and receiver opening 42 are open to the inner surface of the main body portion 30 of the upper mounting frame 24 and are defined in a protrusion 45 that extends from the main body portion 30.The latch pocket 44 and receiver opening 42 are separated by a divider 46.This arrangement holds the stationary portion 41 within receiver opening 42 and allows the latch portion 43 to flex or pivot within latch pocket 44.The latch portion 43 includes a beak 48 that mates with or captures the ledge 40 on the lower mounting frame 22 in the first position.", "The latch portion 43 also includes an engagement surface 47.To release the lower mounting frame 22 a small object such as the tip of a pen or a paper clip is inserted into a release opening 50 that is defined in the protrusion 45 and/or main body portion 30 and communicated with the latch pocket 44.Once the object is inserted through the release opening 50 it contacts the engagement surface 47 and pivots the beak 48 so that it disengages from the ledge 40.Gravity then causes the lower mounting frame 22 to pivot downwardly, as is shown in FIG.", "5B in hidden lines.", "In another embodiment, the latch member 38 can be on the lower mounting frame 22 and the ledge 40 can be on the upper mounting frame 24.In a preferred embodiment, the hinge assembly 36 includes opposing pivot pins 52 located on the second end of the upper mounting frame 24 and complementary pivot openings 54 and slots 56 defined in the second end of the lower mounting frame 22.Preferably, the pivot pins 52 protrude inwardly into central opening 31.However, the pivot pins 52 can also protrude or extend outwardly.", "As shown in FIG.", "5A, to connect the lower mounting frame 22 to the upper mounting frame 24, the open end of the slots 56 are positioned over the pivot pins 52 and the lower mounting frame 22 is then moved downwardly into place so that the pivot pins 52 move all the way to the closed end of the slots 56 (referred to herein as the pivot openings 54).", "In a preferred embodiment, the slots 56 include a portion that is parallel to the upper and lower surfaces of the lower mounting frame 22 and a portion that is angled relative thereto.", "In another embodiment, the slots 56 can be omitted and only closed pivot openings 54 can be used.", "As shown in FIG.", "5B, the lower mounting frame is then pivoted upwardly from the second position (shown in hidden lines) to the first position (shown in solid lines) where the ledge 40 engages the beak 48 of the latch member 38.When moving to the first position, an inclined edge on the ledge 40 pushes against an inclined edge on the beak 48 to pivot the beak 48 out of the way so the beak 48 and ledge 40 can engage one another.", "As shown in FIGS.", "5-9, in a preferred embodiment, the lower mounting frames 22 include a main body portion 88 that includes first 88a, second 88b, third 88c and fourth sides 88d, a bottom surface 88e and a top edge 88f.", "As shown, the ledge 40 is preferably positioned on the first side 88a and the pivot slots 56 (and pivot openings 54) are defined in the third 88c and fourth sides 88d of the main body portion 88.The first portion of the pivot slots 56 extends generally parallel to the bottom surface 88e of the main body portion 88 and the second portion of the pivot slots 56 extends or angles upwardly from the first portion and is open to the top edge 88f of the main body portion 88.As shown in FIGS.", "3-9, in a preferred embodiment, the upper mounting frames 24 include a plurality of electrical connection cylinders 58 thereon.", "The cylinders 58 are provisions for wiring.", "A preexisting zip-tie mount for wires clips into the cylinders 58.They basically receive a small loop with a built-in zip-tie that has a Christmas tree shaped wire harness on the end of it that clicks/fits into that cylinder.", "This allows wiring to be run between the individual components.", "In a preferred embodiment, the bezels 26 include tabs 60 extending therefrom that are received in channels 62 defined in the upper mounting frames 24.In a preferred embodiment, the lower mounting frames 22 also include alignment tabs 64 extending upwardly therefrom that are received in alignment openings 66 in the upper mounting frame.", "This helps align the lower mounting frame 22 with the upper mounting frame 24 so that the latch member 38 properly aligns with the ledge 40.With reference to FIG.", "6, the air extractor module 14 includes the lower mounting frame 22, the upper mounting frame 24, the bezel 26 and the air extractor assembly 28.The air extractor assembly 28 is mounted within the lower mounting frame 22 and includes a grill 68 that snap fits onto the lower mounting frame 22.The lower mounting frame 22 includes the slots 56 and pivot openings 54 defined therein, as well as ledge 40.With reference to FIG.", "7, the oxygen module 20 includes the upper mounting frame 24, the lower mounting frame 22 and the oxygen box 70 (which includes components such as the oxygen mask).", "The lower mounting frame 22 of the oxygen module 20 includes two ledges 40 for mating with two latch members 38 on the upper mounting frame 24.The hinge assembly 36 is different than the hinge assembly 36 on the other three components.", "The hinge assembly 36 includes complementary upper and lower curved hinge members 72 and 74 that engage one another and allow the lower mounting frame 22 and oxygen box 70 to pivot with respect to the upper mounting frame 24.As shown, the oxygen box 70 is attached to the lower mounting frame 22 by threaded fasteners.", "With reference to FIG.", "8, the speaker module 16 includes the lower mounting frame 22, the upper mounting frame 24, the bezel 26 and the speaker 76.The lower mounting frame 22 includes the slots 56 and pivot openings 54 defined therein as well as the speaker grill 78 and ledge 40.With reference to FIG.", "9, the light module 18 includes the lower mounting frame 22, the upper mounting frame 24, the bezel 26 and the light assembly 80, which includes a housing 82 and lights 84 (e.g., LEDs) therein.", "The lower mounting frame 22 includes the slots 56 and pivot openings 54 defined therein as well as the lens cover 86 and ledge 40.FIG.", "10 shows the entire ceiling panel assembly 10 inserted into the shell of a lavatory 100.Unless the context clearly requires otherwise, throughout the description and the claims, the words “comprise,” “comprising,” and the like are to be construed in an inclusive sense, as opposed to an exclusive or exhaustive sense; that is to say, in the sense of “including, but not limited to.” As used herein, the terms “connected,” “coupled,” or any variant thereof, means any connection or coupling, either direct or indirect, between two or more elements; the coupling of connection between the elements can be physical, logical, or a combination thereof.", "Additionally, the words “herein,” “above,” “below,” and words of similar import, when used in this application, shall refer to this application as a whole and not to any particular portions of this application.", "Where the context permits, words in the above Detailed Description of the Preferred Embodiments using the singular or plural number may also include the plural or singular number respectively.", "The word “or” in reference to a list of two or more items, covers all of the following interpretations of the word: any of the items in the list, all of the items in the list, and any combination of the items in the list.", "The above-detailed description of embodiments of the disclosure is not intended to be exhaustive or to limit the teachings to the precise form disclosed above.", "While specific embodiments of and examples for the disclosure are described above for illustrative purposes, various equivalent modifications are possible within the scope of the disclosure, as those skilled in the relevant art will recognize.", "Further, any specific numbers noted herein are only examples: alternative implementations may employ differing values, measurements or ranges.", "The teachings of the disclosure provided herein can be applied to other systems, not necessarily the system described above.", "The elements and acts of the various embodiments described above can be combined to provide further embodiments.", "Any measurements described or used herein are merely exemplary and not a limitation on the present invention.", "Other measurements can be used.", "Further, any specific materials noted herein are only examples: alternative implementations may employ differing materials.", "Any patents and applications and other references noted above, including any that may be listed in accompanying filing papers, are incorporated herein by reference in their entirety.", "Aspects of the disclosure can be modified, if necessary, to employ the systems, functions, and concepts of the various references described above to provide yet further embodiments of the disclosure.", "These and other changes can be made to the disclosure in light of the above Detailed Description of the Preferred Embodiments.", "While the above description describes certain embodiments of the disclosure, and describes the best mode contemplated, no matter how detailed the above appears in text, the teachings can be practiced in many ways.", "Details of the system may vary considerably in its implementation details, while still being encompassed by the subject matter disclosed herein.", "As noted above, particular terminology used when describing certain features or aspects of the disclosure should not be taken to imply that the terminology is being redefined herein to be restricted to any specific characteristics, features or aspects of the disclosure with which that terminology is associated.", "In general, the terms used in the following claims should not be construed to limit the disclosures to the specific embodiments disclosed in the specification unless the above Detailed Description of the Preferred Embodiments section explicitly defines such terms.", "Accordingly, the actual scope of the disclosure encompasses not only the disclosed embodiments, but also all equivalent ways of practicing or implementing the disclosure under the claims.", "Accordingly, although exemplary embodiments of the invention have been shown and described, it is to be understood that all the terms used herein are descriptive rather than limiting, and that many changes, modifications, and substitutions may be made by one having ordinary skill in the art without departing from the spirit and scope of the invention." ] ]
Patent_15875980
[ [ "TOUCH FREE OPERATION OF ABLATOR WORKSTATION BY USE OF DEPTH SENSORS", "An inventive system and method for touch free operation of an ablation workstation is presented.", "The system can comprise a depth sensor for detecting a movement, motion software to receive the detected movement from the depth sensor, deduce a gesture based on the detected movement, and filter the gesture to accept an applicable gesture, and client software to receive the applicable gesture at a client computer in an ablation workstation for performing a task in accordance with client logic based on the applicable gesture.", "The system can also comprise hardware for making the detected movement an applicable gesture.", "The system can also comprise voice recognition providing voice input for enabling the client to perform the task based on the voice input in conjunction with the applicable gesture.", "The applicable gesture can be a movement authorized using facial recognition." ], [ "1.A system for touch-free operation of an ablator workstation by an associated user, comprising: a depth sensor configured to detect an initial location and a subsequent location of a body part of the associated user; and a processor with a memory device, wherein the memory device is configured to store instructions that, when executed by the processor, cause the processor to: receive the detected initial location and the detected subsequent location of the body part, deduce a gesture based on the detected initial location and the detected subsequent location, validate the gesture based on a physical characteristic of the gesture, predict a location of a subsequent user movement location based on an initial user movement location, authorize the gesture as being from the associated user when the subsequent user movement location is within the predicted location, authorize the gesture as being from the associated user based on facial recognition when the subsequent user movement location is outside the predicted location, cause the ablator workstation to perform an ablator task after the gesture is validated and authorized.", "2.The system of claim 1, wherein the ablator task with which the gesture is defined is based on a state of the processor.", "3.The system of claim 1, wherein the gesture is authorized when a hardware device is operated during the gesture.", "4.The system of claim 1, wherein a different ablator task is caused to be performed when voice input is received in conjunction with the gesture.", "5.The system of claim 1, wherein the ablator workstation is disassociated from the associated user after a period of motionlessness.", "6.The system of claim 1, wherein the ablator task is caused to be performed when the gesture is defined.", "7.The system of claim 1, wherein association of the ablator workstation to the user gives the user control of the ablator workstation.", "8.The system of claim 1, wherein the task is one of changing power settings of an electrode, changing maximum allowed temperature for the electrode, changing ablation mode, electrode selection for ablation, and electrode deselection for ablation.", "9.The system of claim 1, wherein the gesture is at least one of a head motion, a hand motion, and a body motion.", "10.A non-transitory computer readable storage device storing a program of instructions executable by a machine to perform a method for touch-free operation of an ablator workstation by an associated user, comprising: detecting an initial location and a subsequent location of a body part of the associated user; receiving the detected initial location and the detected subsequent location of the body part, deducing a gesture based on the detected initial location and the detected subsequent location, validating the gesture based on a physical characteristic of the gesture, predicting a location of a subsequent user movement location based on an initial user movement location, authorizing the gesture as being from the associated user when the subsequent user movement location is within the predicted location, authorizing the gesture as being from the associated user based on facial recognition when the subsequent user movement location is outside the predicted location, causing the ablator workstation to perform an ablator task after the gesture is validated and authorized.", "11.The non-transitory computer readable storage device of claim 10, wherein the ablator task with which the gesture is defined is based on a state of the processor.", "12.The non-transitory computer readable storage device of claim 10, wherein the gesture is authorized when a hardware device is operated during the gesture.", "13.The non-transitory computer readable storage device of claim 10, wherein a different ablator task is caused to be performed when voice input is received in conjunction with the gesture.", "14.The non-transitory computer readable storage device of claim 10, wherein the ablator workstation is disassociated from the associated user after a period of motionlessness.", "15.The non-transitory computer readable storage device of claim 10, wherein the ablator task is caused to be performed when the gesture is defined.", "16.The non-transitory computer readable storage device of claim 10, wherein association of the ablator workstation to the user gives the user control of the ablator workstation.", "17.The non-transitory computer readable storage device of claim 10, wherein the task is one of changing power settings of an electrode, changing maximum allowed temperature for the electrode, changing ablation mode, electrode selection for ablation, and electrode deselection for ablation.", "18.The non-transitory computer readable storage device of claim 10, wherein the gesture is at least one of a head motion, a hand motion, and a body motion.", "19.A non-transitory computer readable storage device storing a program of instructions executable by a machine to perform a method for touch-free operation of an ablator workstation by an associated user, comprising: detecting location and motion movements of a body part of the associated user, receiving detected location and motion movements of the body part, deducing a gesture based on the received motion movement of the body part, validating the gesture based on a physical characteristic of the gesture, determining whether the validated gesture is defined with an ablator task, causing the ablator workstation to perform the ablator task, comparing a difference between an initial movement location and a subsequent movement location, authorizing the gesture as being from the associated user when the difference is within a predicted location, and associating the ablator workstation to the user, thereby giving control of the ablator workstation to the associated user, wherein the ablator workstation is disassociated from the associated user after a period of motionlessness.", "20.The non-transitory computer readable storage device of claim 19, wherein a different ablator task is caused to be performed when voice input is received in conjunction with the gesture." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>In an operating room, the physician needs to stay sterile; hence he or she cannot physically access a computer for assistance during surgery.", "Accordingly, any task the physician wants to perform using computer applications on operating room devices, such as an ablator workstation, must actually be performed by another.", "There is a need for the physician to be able to operate these devices without physically touching the device or its accessories, e.g., its keyboard, screen, mouse, etc." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>An inventive system and method for touch free operation of an ablator workstation is presented.", "The system comprises a depth sensor for detecting a movement, a motion software module operable to receive the detected movement from the depth sensor, deduce a gesture based on the detected movement, and filter the gesture to accept an applicable gesture, and a client software module operable to receive the applicable gesture at a client computer in or associated with the ablator workstation for performing a task in accordance with client logic based on the applicable gesture.", "In one aspect, the task is one of changing power settings of one or more electrodes, changing maximum allowed temperature for one or more electrodes, changing ablation mode between unipolar and bipolar, selecting and deselecting electrodes for ablation.", "In one aspect, the movement is at least one of a head motion, a hand motion and a body motion and the gesture is further deduced based on a short history.", "In one aspect, the system further comprises hardware for making the detected movement an applicable gesture.", "In one aspect, the applicable gesture is one or more of the detected movement performed by a user determined to be authorized using facial recognition, and a recognized gesture in accordance with the client logic.", "In one aspect, filtering of the gesture is performed by determining whether the gesture is authorized and valid.", "In one aspect the system further comprises a client communication module for receiving the application gesture at the client computer.", "In one aspect, the system further comprises voice recognition providing voice input for enabling the client to perform the task based on the voice input in conjunction with the applicable gesture.", "An inventive method for touch free operation of an ablator workstation comprises detecting a movement using a depth sensor, deducing, using a CPU, a gesture based on the detected movement, filtering the gesture to accept an applicable gesture, receiving the applicable gesture at a client in the ablator workstation, and performing a task in accordance with client logic based on the applicable gesture.", "A computer readable storage medium storing a program of instructions executable by a machine to perform one or more methods described herein also may be provided." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "13/347,987 filed Jan. 11, 2012, the entire contents of which is incorporated herein by reference.", "This application is related to commonly-owned, co-pending U.S. patent application Ser.", "No.", "13/347,943 filed on Jan. 11, 2012 now U.S. Pat.", "No.", "9,625,993 entitled TOUCH FREE OPERATION OF DEVICES BY USE OF DEPTH SENSORS, the entire contents and disclosure of which is expressly incorporated by reference herein as if fully set forth herein.", "FIELD OF THE INVENTION The present invention relates generally to touch free operation of operating room devices by using depth sensors and, in some situations, voice recognition.", "BACKGROUND OF THE INVENTION In an operating room, the physician needs to stay sterile; hence he or she cannot physically access a computer for assistance during surgery.", "Accordingly, any task the physician wants to perform using computer applications on operating room devices, such as an ablator workstation, must actually be performed by another.", "There is a need for the physician to be able to operate these devices without physically touching the device or its accessories, e.g., its keyboard, screen, mouse, etc.", "SUMMARY OF THE INVENTION An inventive system and method for touch free operation of an ablator workstation is presented.", "The system comprises a depth sensor for detecting a movement, a motion software module operable to receive the detected movement from the depth sensor, deduce a gesture based on the detected movement, and filter the gesture to accept an applicable gesture, and a client software module operable to receive the applicable gesture at a client computer in or associated with the ablator workstation for performing a task in accordance with client logic based on the applicable gesture.", "In one aspect, the task is one of changing power settings of one or more electrodes, changing maximum allowed temperature for one or more electrodes, changing ablation mode between unipolar and bipolar, selecting and deselecting electrodes for ablation.", "In one aspect, the movement is at least one of a head motion, a hand motion and a body motion and the gesture is further deduced based on a short history.", "In one aspect, the system further comprises hardware for making the detected movement an applicable gesture.", "In one aspect, the applicable gesture is one or more of the detected movement performed by a user determined to be authorized using facial recognition, and a recognized gesture in accordance with the client logic.", "In one aspect, filtering of the gesture is performed by determining whether the gesture is authorized and valid.", "In one aspect the system further comprises a client communication module for receiving the application gesture at the client computer.", "In one aspect, the system further comprises voice recognition providing voice input for enabling the client to perform the task based on the voice input in conjunction with the applicable gesture.", "An inventive method for touch free operation of an ablator workstation comprises detecting a movement using a depth sensor, deducing, using a CPU, a gesture based on the detected movement, filtering the gesture to accept an applicable gesture, receiving the applicable gesture at a client in the ablator workstation, and performing a task in accordance with client logic based on the applicable gesture.", "A computer readable storage medium storing a program of instructions executable by a machine to perform one or more methods described herein also may be provided.", "BRIEF DESCRIPTION OF THE DRAWINGS The present invention will be more fully understood from the following detailed description of the embodiments thereof, taken together with the drawings.", "Further features as well as the structure and operation of various embodiments are described in detail below with reference to the accompanying drawings.", "In the drawings, like reference numbers indicate identical or functionally similar elements.", "FIG.", "1 is a block diagram of an embodiment of the inventive system.", "FIG.", "2 is a block diagram of another embodiment of the inventive system.", "FIG.", "3 is a flow diagram of the inventive method.", "DETAILED DESCRIPTION An inventive technique for touch free operation of an ablator workstation is presented.", "In accordance with this novel technology, a person can perform the ablator workstation functions without touching any computer apparatus, e.g., a monitor, a keyboard, a mouse, etc.", "As shown in FIG.", "1, the system in one embodiment comprises various components including a depth sensor 10, a computer or CPU 12, a communication medium 14 and a client computer 16 which is part of the ablator workstation.", "A Motion Detection Software Module 18 can reside in the CPU 12.The client computer 16 can control a Target Software Module 20.A Communication Client Module 22 can reside in the client computer 16.In one embodiment, the system can also include voice recognition, such as a microphone or a microphone array 28.The depth sensor 10 typically includes a depth-aware camera that not only records images but also records depth, allowing 3D representation of the recorded images.", "As is known to one skilled in the art, a depth sensor is connected to a computer which uses the depth map from the sensor to deduce motion, e.g., hand gestures, poses and positions of a user.", "In a medical setting, the user can be the system operator, generally a physician.", "In one embodiment of the present invention, the depth sensor tracks movements of the head as well as the hands.", "In another embodiment, the depth sensor tracks not only the hands and head but also the overall body location, such as movement toward and/or away from the computer screen or monitor.", "In one embodiment, the depth sensor 10 can be implemented using modules or middleware such as Microsoft® Kinect, ASUS® Xtion PRO, or ASUS® Xtion PRO LIVE.", "More than one depth sensor can be used in parallel to extend occlusion handling, field of view and accuracy.", "Any sensor, such as a camera which can provide a depth map with sufficient detail in real time, may be fitted for use with the inventive system.", "The depth sensor obtains location information and forwards this information to CPU 12 for processing as discussed below.", "As is known to one skilled in the art, software and a driver provided by the depth sensor 10 can be used to obtain this location information.", "The Motion Detection Software Module or Motion Software 18 in the CPU 12 obtains the location information, such as locations of the operator's relevant body parts, e.g., hand, head, feet, etc., a few times a second, from the depth sensor 10.Each received motion and/or body location is tracked and saved to a short history of movements file or data set.", "The motion software can include software that uses the data detected as movements of the body parts from the motion software 18 along with the short history of movements data to deduce more complex movements and process the data into significant gestures, such as a motion forward, a circular motion of the hand, or a nod with the head.", "For example, linear movements and/or circular movements of the hand are detected and parameters are calculated to quantify these movements.", "The motion software associates particular attributes, such as the extent of the movement, the time it was captured, its speed and/or duration, etc., with each gesture.", "The system can be associated with a specific user by using body tracking, that is, starting from an initial configuration, tracking a user's individual movements, and ensuring that only motions by that specific user are responded to.", "For example, locations of the body and movements are tracked and so long as the differences from locations in the previous frame are small enough, the movements are assumed to be the same person.", "The system can also be associated with a specific user by employing face detection and/or recognition with the camera in the depth sensor.", "The system can use face detection and/or recognition to verify that the body is the one associated with the recognized face in each state or position.", "These techniques can be combined, for example, using body tracking while the movements are small and, whenever there is an uncertainty, using face detection and/or recognition to find the correct user, and then continue as before.", "The Motion Detection Software Module 18 can also include a filter that can decide which motions or movements to accept and which need to be ignored or filtered out as not applicable, e.g., invalid and/or unauthorized.", "An invalid, e.g., irrelevant, motion can be a motion that is not acceptable to the Motion Detection Software Module 18.For example, if a motion is too small or slow to filter uncontrollable natural movements of the user, then this motion would be invalid or irrelevant.", "An unauthorized motion is a motion that is not performed by the proper user and/or not performed in accordance with predetermined conditions.", "For example, for safety and/or security, certain motions can require physical input and/or interaction with a corresponding hardware device, such as the pressing of a foot pedal during a particular hand motion and/or at a given time during the procedure.", "In one embodiment when multiple cameras are used and one camera has a view of the physician's full body, it could be determined whether the specific physician provided the appropriate physical input.", "This security measure, e.g., requiring physical input in addition to detected motions, trusts that the people in the room are not trying to tamper with the system; instead, the security measure provides extra security to prevent critical functions from happening unintentionally, in case the physician/user made some gesture by mistake.", "Connecting a hardware device to the system can prevent unwanted actions by the system, as indicated above.", "This can be critical in medical software.", "The hardware device (not shown), e.g., a foot pedal, could be connected to the client computer 16 and/or the ablator workstation which it is responsible for receiving and interpreting the device actions, e.g., foot pedal presses, etc., and using these actions for the internal logic of the client.", "The hardware device could also be connected to the CPU 12 doing the motion detection and its software in which case the device state could be sent with the motions detected and/or some motions could be filtered according to the state of the device.", "The motions not filtered out are sent through the communication medium 14 to the communications client module 20 at the client computer 16.The communication medium 14 can be a serial, local area network (LAN), wireless LAN (WLAN), Bluetooth, wireless, etc.", "The client computer 16 receives the interpreted motions, e.g., gesture.", "The Target Software Module 20 determines if the received motion is valid.", "An invalid motion can be a motion that is not defined within the Target Software Module 20.For example, when one client software module is active, then a motion toward the screen can be defined to change the mode to unipolar, but if another client were active, this motion toward the screen may not be defined so that this motion would be inappropriate or irrelevant.", "In addition, an invalid motion can be one that is not permitted unless certain preconditions are met.", "For example, when a hardware device is connected to the client computer, a motion can be permitted or valid only when it is performed in conjunction with an action of the hardware device; for example, a wave motion may only be valid when it is performed while a foot pedal of a hardware device is pressed.", "Client logic, e.g., Target Software Module 20, determines how to respond to each recognized, e.g., valid, gesture.", "The Target Software Module 20 is associated with the ablator workstation and the client logic may be able to perform tasks such as changing the power settings, selecting and deselecting electrodes, changing the maximum allowed temperature per electrode, etc.", "Accordingly, the client software may determine, using its logic, that if the gesture is a fist, the client logic can perform the task of selecting an electrode, and if the gesture is an upward hand motion, the client logic can perform the task of increasing the temperature of the selected electrode.", "To operate the inventive system, the user must first gain control and activate touch free operation.", "To gain control, the user makes the system acknowledge that the user will be sending instructions.", "The system then responds to the instructions which are, as discussed above, in the form of different hand gestures and/or head and/or other body movements.", "Control can be released when it is no longer needed or after a period of motionlessness is detected.", "Gaining control can be achieved by either using a focusing gesture, for example, a hand wave or head movement, or by use of hardware, such as a foot pedal that enables control while pressed, or by a voice command.", "The motions detected by the system do not have fixed functions.", "The system associates meaning to each gesture, pose or movement depending on its context according to the function and mode in which the user is currently operating the client computer 16.For example, while the user is operating the client in selection mode, a head movement may change the mode from unipolar to bipolar and vice versa.", "During the time that the touch free control is activated, a visual indication can be shown to the user.", "Optionally, an audible indication may be given upon activation and deactivation of the touch free control.", "In one embodiment, the hands free operation can be augmented with voice input which could be used separately or in conjunction with detected motions.", "Microsoft® Kinect, for example, has peripheral microphones and can detect the direction from which the voice recognized came.", "This and/or other voice recognition techniques can be used to capture voice commands and selectively filter the voice commands from the user.", "The voice commands can be combined with the gestures.", "For example, the user could say “Ablator Power” and then move his hand up and down to control the power.", "In another example, the user could say “Ablator Temperature” and then move his hand up and down to control the temperature setting.", "Yet another example could be the user saying “Ablator Electrodes”, and the motion of the hand left and right would highlight the electrode controls on the screen and a “press forward” will toggle the selection.", "In another example, the user could say “Ablator Electrodes None/Even/Odd/All” will select or deselect electrodes appropriately.", "The client computer performs all the logic in deciding what each motion means in conjunction with the most recently recognized voice command.", "In one version of this embodiment, some commands may be performed by the use of voice commands only or gestures only e.g., setting the ablation mode can be performed just by saying “Ablator Bipolar” or “Ablator Unipolar” without the need for a gesture.", "FIG.", "2 shows an embodiment having modules of both the CPU and the client computer in one workstation 26.The system in the embodiment shown in FIG.", "2 has the Depth Sensor 10, Voice Recognition 24, Motion Detection Software Module 18 and Target Software Module 20, having the same functionality as those components in FIG.", "1.In this embodiment, however, only one workstation 26 is used and the Target Software Module 20 contains a client communication module.", "The invention is not limited to either the configuration of FIG.", "1 or FIG.", "2.Multiple CPUs, each having one or more modules, can also be used.", "FIG.", "3 is a flow diagram of the inventive method.", "In step SI, the user gains control of the touch free control system, typically by performing a motion, a voice command or pressing a foot pedal.", "In step S2, movement, including change of location, is detected by the depth sensor 10 and transmitted to the CPU 12.In step S3, the CPU tracks and saves a short history of the movements and/or location changes.", "In step S4, the CPU 12 uses the motion software to deduce, from the received motion in accordance with the short history, a more complex movement or gesture.", "In steps S5 and S6, filtering is performed.", "In step S5, it is determined whether the gesture is performed by the authorized or proper user by determining whether the movement is within a predicted location and/or by performing facial recognition.", "If the gesture is determined to be by the authorized user (S5=YES), then processing continues at step S6 where the gesture is validated by the CPU.", "If the gesture is valid (S6=YES), then it is sent to the client computer and additional motion tracking is resumed at step S3.At step S7, the gesture is received at the communication client module on the client computer.", "If the gesture is recognized by the active Target Software Module (S8=YES), then, at step S9, the client computer performs a device function or operation, e.g., task, at the ablator workstation in accordance with the client logic or Target Software Module, based on the deduced gesture.", "These tasks include, but are not limited to, changing the power settings of one or more electrodes, changing the maximum allowed temperature for one or more electrodes, changing the ablator mode (unipolar or bipolar), selecting and deselecting electrodes for ablator, etc.", "Once the motion software sends the gesture to the client computer (when S6=YES), the motion software goes back to responding to the next detected motion and/or body location.", "In one embodiment, performing an authorized movement also requires determining if the movement is performed in conjunction with hardware such as another device.", "In this embodiment, an authorized movement must include both a complex movement deduced by the software and an additional action, such as stepping on a foot pedal.", "This authorization can be performed after step S5, when S5=YES, and before step S6.If the detected movement is not authorized (S5=NO) or the detected movement is not valid (S6=NO), processing continues at step S3.If the gesture is not recognized by the client software (S8=NO), then no task is performed.", "The inventive system advantageously enables tasks to be performed by an operating room device using head tracking and/or other motion detection techniques allowing the doctor or other system user to perform certain actions while still using at least one of his hands for catheter navigation.", "Beneficially, the system can filter and forward gestures for allowed personnel only.", "This ensures that the system is only controlled by the intended people.", "Hand gestures and head movements and other actions by other people can be ignored.", "Various aspects of the present disclosure may be embodied as a program, software, or computer instructions embodied or stored in a computer or machine usable or readable medium, which causes the computer or machine to perform the steps of the method when executed on the computer, processor, and/or machine.", "A program storage device readable by a machine, e.g., a computer readable medium, tangibly embodying a program of instructions executable by the machine to perform various functionalities and methods described in the present disclosure is also provided.", "The system and method of the present disclosure may be implemented and run on a general-purpose computer or special-purpose computer system.", "The computer system may be any type of known or will be known systems and may typically include a processor, memory device, a storage device, input/output devices, internal buses, and/or a communications interface for communicating with other computer systems in conjunction with communication hardware and software, etc.", "The system also may be implemented on a virtual computer system, colloquially known as a cloud.", "The computer readable medium is a computer readable storage device, which may be, for example, a magnetic, optical, electronic, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any suitable combination of the foregoing; however, the computer readable storage device is not limited to these examples.", "Additional particular examples of the computer readable storage device can include: a portable computer diskette, a hard disk, a magnetic storage device, a portable compact disc read-only memory (CD-ROM), a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or Flash memory), an electrical connection having one or more wires, an optical fiber, an optical storage device, or any appropriate combination of the foregoing; however, the computer readable storage medium is also not limited to these examples.", "Any tangible medium that can contain, or store a program for use by or in connection with an instruction execution system, apparatus, or device could be a computer readable storage device.", "The terms “computer system” and “computer network” as may be used in the present application may include a variety of combinations of fixed and/or portable computer hardware, software, peripherals, and storage devices.", "The computer system may include a plurality of individual components that are networked or otherwise linked to perform collaboratively, or may include one or more stand-alone components.", "The hardware and software components of the computer system of the present application may include and may be included within fixed and portable devices such as desktop, laptop, and/or server, and network of servers (cloud).", "A module may be a component of a device, software, program, or system that implements some “functionality”, which can be embodied as software, hardware, firmware, electronic circuitry, or etc.", "The embodiments described above are illustrative examples and it should not be construed that the present invention is limited to these particular embodiments.", "Thus, various changes and modifications may be effected by one skilled in the art without departing from the spirit or scope of the invention as defined in the appended claims." ] ]
Patent_15875988
[ [ "DOCKING STATION FOR TABLET DEVICE", "A docking station for a tablet device includes a security frame that is releasably connected to a pedestal.", "An upper head portion of the pedestal is rotatable through three degrees of freedom to allow for angular adjustment of the frame as it retains a tablet device.", "Electrical conductivity is maintained through the rotational connection." ], [ "1.A docking station for a tablet device, the docking station comprising: a frame assembly for retaining the tablet device, the frame assembly including a frame adapter and a first electrical connection, the frame adapter being electrically connectable to the tablet device via the first electrical connection; a pedestal assembly including a head portion and a base portion, the head portion being connected to the base portion, the head portion including a pedestal adapter and a second electrical connection, the pedestal adapter being electrically connectable to a power source via the second electrical connection, the pedestal adapter being releasably connectable to the frame adapter; the pedestal adapter and the frame adapter being configured such that the pedestal assembly and the frame assembly are electrically connected whenever the pedestal adapter is connected to the frame adapter, the pedestal adapter and the frame adapter being configured such that the pedestal assembly is electrically unconnected to the frame assembly whenever the pedestal adapter is not connected to the frame adapter; the frame assembly being positionable relative to the base portion of the pedestal assembly in a landscape orientation and in a rotated orientation, the rotated orientation being different from the landscape orientation, the pedestal assembly and the frame assembly being configured such that the pedestal adapter and the frame adapter are connected to each other when the frame assembly is in the landscape orientation, the pedestal assembly and the frame assembly being configured such that the pedestal adapter and the frame adapter are connected to each other when the frame assembly is in the rotated orientation, the frame assembly being electrically connected to the pedestal assembly when the frame assembly is in the landscape orientation, the frame assembly being electrically connected to the pedestal assembly when the frame assembly is in the rotated orientation.", "2.The docking station as set forth in claim 1 wherein the docking station further comprises a lock assembly moveable between a locked condition and an unlocked condition, the lock assembly being configured to lock the frame assembly to the pedestal assembly in the locked condition, the lock assembly being configured to permit detachment of the frame assembly from the pedestal assembly when the lock assembly is in the unlocked condition.", "3.The docking station as set forth in claim 1 wherein the frame adapter includes a first electrical interface and the pedestal adapter includes a second electrical interface, the first electrical interface being configured to connect with the second electrical interface in a manner such that the pedestal assembly and the frame assembly are electrically connected when the pedestal adapter is connected to the frame adapter.", "4.The docking station as set forth in claim 1 wherein the head portion of the pedestal assembly is configured to pivot about a horizontal axis to adjust a vertical position of the frame assembly when the pedestal adapter is connected to the frame adapter.", "5.The docking station as set forth in claim 1 wherein the head portion further comprises a face, a head portion axis being generally normal to the face, the frame assembly being generally normal to the head portion axis when in the landscape orientation, the frame assembly being generally normal to the head portion axis when in the rotated orientation.", "6.A docking station for a tablet device, the docking station comprising: a frame assembly for retaining the tablet device, the frame assembly including a frame adapter, a first electrical connection and a first electrical interface, the first electrical interface being electrically connectable to the tablet device via the first electrical connection; a pedestal assembly including a head portion and a base portion, the head portion being connected to the base portion, the head portion including a pedestal adapter, a second electrical connection and a second electrical interface, the second electrical interface being electrically connectable to a power source via the second electrical connection, the pedestal adapter being releasably connectable to the frame adapter; the first electrical interface being electrically connected to the second electrical interface whenever the pedestal adapter is connected to the frame adapter, the first electrical interface being electrically unconnected to the second electrical interface whenever the pedestal adapter is not connected to the frame adapter; the frame assembly being positionable relative to the base portion of the pedestal assembly in a landscape orientation and in a rotated orientation, the rotated orientation being different from the landscape orientation, the pedestal assembly and the frame assembly being configured such that the pedestal adapter and the frame adapter are connected to each other when the frame assembly is in the landscape orientation, the pedestal assembly and the frame assembly being configured such that the pedestal adapter and the frame adapter are connected to each other when the frame assembly is in the rotated orientation, the frame assembly being electrically connected to the pedestal assembly when the frame assembly is in the landscape orientation, the frame assembly being electrically connected to the pedestal assembly when the frame assembly is in the rotated orientation.", "7.The docking station as set forth in claim 6 wherein the docking station further comprises a lock assembly moveable between a locked condition and an unlocked condition, the lock assembly being configured to lock the frame assembly to the pedestal assembly in the locked condition, the lock assembly being configured to permit detachment of the frame assembly from the pedestal assembly when the lock assembly is in the unlocked condition.", "8.The docking station as set forth in claim 7 wherein the lock assembly comprises a sensor configured to receive a wireless signal, the lock assembly being configured to move from the locked condition to the unlocked condition upon the sensor receiving the wireless signal.", "9.The docking station as set forth in claim 8 wherein the sensor is configured to receive an RFID signal.", "10.The docking station as set forth in claim 6 wherein the first electrical interface is a first connector fitting and the second electrical interface is a second connector fitting.", "11.The docking station as set forth in claim 10 wherein the first connector fitting is a female connector fitting and the second connector fitting is a male connector fitting.", "12.The docking station as set forth in claim 6 wherein the first electrical connection includes a connector fitting, the connector fitting being connectable to the tablet device.", "13.The docking station as set forth in claim 12 wherein the frame assembly further includes a stem portion, the connector fitting being electrically connected to the frame adapter via the stem portion.", "14.The docking station as set forth in claim 6 wherein the first electrical interface forms a portion of the frame adapter and the second electrical interface forms a portion of the pedestal adapter.", "15.The docking station as set forth in claim 6 wherein the head portion further comprises a face, a head portion axis being generally normal to the face, the frame assembly being generally normal to the head portion axis when in the landscape orientation, the frame assembly being generally normal to the head portion axis when in the rotated orientation.", "16.A docking station for a tablet device, the docking station comprising: a frame assembly for retaining the tablet device, the frame assembly including a frame adapter, a first electrical connection and a first electrical interface, the first electrical interface being electrically connectable to the tablet device via the first electrical connection; a pedestal assembly including a head portion and a base portion, the head portion being connected to the base portion, the head portion including a pedestal adapter, a second electrical connection and a second electrical interface, the second electrical interface being electrically connectable to a power source via the second electrical connection, the pedestal adapter being releasably connectable to the frame adapter; the first electrical interface being electrically connected to the second electrical interface whenever the pedestal adapter is connected to the frame adapter, the first electrical interface being electrically unconnected to the second electrical interface whenever the pedestal adapter is not connected to the frame adapter; the head portion being configured such that the frame assembly is rotatable relative to the base portion of the pedestal assembly between a landscape orientation and a rotated orientation while the frame adapter is connected to the pedestal adapter, the rotated orientation being different from the landscape orientation, the pedestal assembly and the frame assembly being configured such that the pedestal adapter and the frame adapter are connected to each other when the frame assembly is in the landscape orientation, the pedestal assembly and the frame assembly being configured such that the pedestal adapter and the frame adapter are connected to each other when the frame assembly is in the rotated orientation, the first electrical interface being electrically connected to the second electrical interface when the frame assembly is in the landscape orientation, the first electrical interface being electrically connected to the second electrical interface when the frame assembly is in the rotated orientation.", "17.The docking station as set forth in claim 16 wherein the docking station further comprises a lock assembly moveable between a locked condition and an unlocked condition, the lock assembly being configured to lock the frame assembly to the pedestal assembly in the locked condition, the lock assembly being configured to permit the detachment of the frame assembly from the pedestal assembly when the lock assembly is in the unlocked condition.", "18.The docking station as set forth in claim 17 wherein the lock assembly comprises a sensor configured to receive a wireless signal, the lock assembly being configured to move from the locked condition to the unlocked condition upon the sensor receiving the wireless signal.", "19.The docking station as set forth in claim 16 wherein the frame assembly further includes a front portion and a back portion, the front portion being connectable to the back portion, the frame assembly being configured to sandwich the tablet device between the front portion and the back portion when the front portion is connected to the back portion.", "20.The docking station as set forth in claim 19 wherein the frame adapter is connected to the back portion.", "21.The docking station as set forth in claim 16 wherein the head portion of the pedestal assembly further includes a protrusion, the frame adapter of the frame assembly being configured to engage the protrusion when the frame adapter is connected to the pedestal adapter.", "22.The docking station as set forth in claim 16 wherein the base portion of the pedestal assembly includes a hollow portion.", "23.The docking station as set forth in claim 22 wherein the second electrical connection includes a cable, the cable extending through the hollow portion.", "24.The docking station as set forth in claim 16 wherein the first electrical connection includes a connector fitting, the connector fitting being connectable to the tablet device.", "25.The docking station as set forth in claim 24 wherein the frame assembly further includes a stem portion, the connector fitting being electrically connected to the frame adapter via the stem portion.", "26.The docking station as set forth in claim 16 wherein the first electrical interface is a first connector fitting and the second electrical interface is a second connector fitting, the second connector fitting being connectable to the first connector fitting.", "27.The docking station as set forth in claim 26 wherein the first connector fitting is a female connector fitting and the second connector fitting is a male connector fitting, the male connector fitting being insertable into the female connector fitting.", "28.The docking station as set forth in claim 16 wherein the rotated orientation is a portrait orientation.", "29.The docking station as set forth in claim 16 wherein the head portion of the pedestal assembly is configured to pivot about a horizontal axis to adjust a vertical position of the frame assembly when the pedestal adapter is connected to the frame adapter.", "30.The docking station as set forth in claim 16 wherein the frame assembly further includes a front portion connectable to a back portion, the frame assembly being configured such that the front portion and the back portion collectively surround the tablet device when the front portion is connected to the back portion, the frame adapter being connected to the back portion." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>In general terms, electronic tablet devices (or “tablets”) have evolved such that they are now performing many of the functions that were formerly performed by laptop or desktop computers.", "The processing capability of tablets now allow them to perform standard business functions.", "Because of their size and portability, one of the problems associated with the use of tablets in a business setting relates to physical security and/or theft of the device itself.", "The design disclosed here addresses these problems." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The following is a summary of the various improvements disclosed in this document.", "The disclosed design is a docking station that is primarily intended to be used in connection with tablet devices.", "Tablet devices are well-known electronic devices.", "They are sometimes called electronic tablets, tablet computers, or just “tablets.” The docking station disclosed here includes a security frame portion for retaining the tablet.", "The security frame portion surrounds the tablet and provides a framework for carrying the tablet from place-to-place while retained within the security frame.", "The frame portion carries or has a first universal adapter that electrically couples the tablet to the frame portion.", "The universal adapter is designed so that it may electrically couple to the different kinds of connection ports that relate to different brands of tablets.", "As a person skilled in the art would know, these connection ports provide a means for transmitting power and data to and from the tablet.", "The docking station also includes a pedestal, or pedestal portion, that normally rests on a workstation surface or the like.", "The pedestal has a connecting head portion that provides a means for releasably connecting the above-described frame portion to the pedestal portion.", "The head portion carries a second universal adapter for electrically coupling the head portion to the first universal adapter on the frame portion, previously described, when the frame portion is connected or “docked” to the pedestal portion.", "Another feature of the design involves a rotational connection between the head portion of the pedestal and a lower base portion of the pedestal.", "The rotational connection enables three degrees of angular orientation or adjustment of the head portion relative to the base portion.", "This, in turn, allows for adjustment of the view angle of the tablet when it is docked.", "The base portion is connectable to or provides electrical connection ports for at least one electrical signal, although preferably, it includes ports for numerous kinds of electrical connections that normally involve power and data.", "A conductor pathway is provided through the base member to the universal adapter carried by the head portion by crossing the rotational connection between the head portion and the base portion.", "This allows electrical connectivity to be maintained regardless of the angular portion of the frame (and tablet) relative to the pedestal.", "Another feature of the design involves locking the frame to the pedestal.", "While this may be accomplished in different ways, the design disclosed here includes an electronic lock for additional security The foregoing summary will become better understood upon review of the attached drawings which are to be taken in conjunction with the written description set forth below." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of and claims priority under 35 USC 120 to U.S. patent application Ser.", "No.", "15/667,436, filed Aug. 2, 2017, entitled “DOCKING STATION FOR TABLET DEVICE,” which is a continuation of U.S. patent application Ser.", "No.", "14/097,171, filed Dec. 4, 2013, now U.S. Pat.", "No.", "9,760,116, entitled “DOCKING STATION FOR TABLET DEVICE,” which claims priority under 35 USC 119 to U.S.", "Provisional Application Ser.", "No.", "61/733,842, filed Dec. 5, 2012, and entitled, “DOCKING STATION FOR TABLET DEVICE,” the entire content of each of which is incorporated herein by reference; this application is related to U.S. patent application Ser.", "No.", "15/875,957, filed Jan. 19, 2018, with attorney docket number 270.P002C2, entitled “DOCKING STATION FOR TABLET DEVICE.” TECHNICAL FIELD The design disclosed below relates to a docking station for a tablet device.", "More particularly, the design relates to a docking station that allows the tablet device to be used as a work station, or alternatively, the tablet device can be undocked and used remotely from the work station position.", "BACKGROUND OF THE INVENTION In general terms, electronic tablet devices (or “tablets”) have evolved such that they are now performing many of the functions that were formerly performed by laptop or desktop computers.", "The processing capability of tablets now allow them to perform standard business functions.", "Because of their size and portability, one of the problems associated with the use of tablets in a business setting relates to physical security and/or theft of the device itself.", "The design disclosed here addresses these problems.", "SUMMARY OF THE INVENTION The following is a summary of the various improvements disclosed in this document.", "The disclosed design is a docking station that is primarily intended to be used in connection with tablet devices.", "Tablet devices are well-known electronic devices.", "They are sometimes called electronic tablets, tablet computers, or just “tablets.” The docking station disclosed here includes a security frame portion for retaining the tablet.", "The security frame portion surrounds the tablet and provides a framework for carrying the tablet from place-to-place while retained within the security frame.", "The frame portion carries or has a first universal adapter that electrically couples the tablet to the frame portion.", "The universal adapter is designed so that it may electrically couple to the different kinds of connection ports that relate to different brands of tablets.", "As a person skilled in the art would know, these connection ports provide a means for transmitting power and data to and from the tablet.", "The docking station also includes a pedestal, or pedestal portion, that normally rests on a workstation surface or the like.", "The pedestal has a connecting head portion that provides a means for releasably connecting the above-described frame portion to the pedestal portion.", "The head portion carries a second universal adapter for electrically coupling the head portion to the first universal adapter on the frame portion, previously described, when the frame portion is connected or “docked” to the pedestal portion.", "Another feature of the design involves a rotational connection between the head portion of the pedestal and a lower base portion of the pedestal.", "The rotational connection enables three degrees of angular orientation or adjustment of the head portion relative to the base portion.", "This, in turn, allows for adjustment of the view angle of the tablet when it is docked.", "The base portion is connectable to or provides electrical connection ports for at least one electrical signal, although preferably, it includes ports for numerous kinds of electrical connections that normally involve power and data.", "A conductor pathway is provided through the base member to the universal adapter carried by the head portion by crossing the rotational connection between the head portion and the base portion.", "This allows electrical connectivity to be maintained regardless of the angular portion of the frame (and tablet) relative to the pedestal.", "Another feature of the design involves locking the frame to the pedestal.", "While this may be accomplished in different ways, the design disclosed here includes an electronic lock for additional security The foregoing summary will become better understood upon review of the attached drawings which are to be taken in conjunction with the written description set forth below.", "BRIEF DESCRIPTION OF THE DRAWINGS In the drawings, like reference numerals and letters refer to like parts throughout the various views, and wherein: FIG.", "1 is a perspective view of a docking station constructed in accordance with the patent claims; FIG.", "2 is a top view of the docking station; FIG.", "3 is a side view of the docking station; FIG.", "4 is a perspective view of a security frame portion of the docking station that holds or retains a tablet; FIG.", "5 is a perspective view of a back-side part of the security frame portion illustrated in FIG.", "4; FIG.", "6 is a perspective view of an adapter portion of the security frame illustrated in FIG.", "4; FIG.", "7 is a perspective view of the back-side of the security frame portion illustrated in FIG.", "4; FIG.", "8 is a perspective view of a pedestal portion of the docking station illustrated in FIG.", "1; FIG.", "9 is an enlarged view of the head of the pedestal portion illustrated in FIG.", "8; FIG.", "10 is a view like FIG.", "9, but is taken from the back-side perspective of the pedestal portion; FIG.", "11 is a view of the lower portion of the pedestal portion illustrated in FIG.", "8, with a cover removed to reveal an electronics board; FIG.", "12 is a perspective view of the docking station, showing angular rotation of the tablet device; and FIG.", "13 is a top view of FIG.", "12 and shows different rotational positions of the tablet device.", "DETAILED DESCRIPTION Referring now to the drawings, and first to FIG.", "1, indicated generally at 10 is a docking station in accordance with the present disclosure.", "The docking station 10 includes a security frame portion, indicated generally at 12, and a pedestal portion, indicated generally at 14.The pedestal portion 14 surrounds and captures a tablet device 16.The outline of the tablet's screen is indicated by dashed line 18 in FIG.", "1.The activating button on the tablet is indicated at 20.Although the frame 12 is illustrated here as surrounding and capturing the tablet 16, it is to be understood that there could be other physical embodiments that perform the same function without completely surrounding the entire or full periphery of the tablet 16.Referring now to FIGS.", "4-7, further details of the frame portion 12 will now be described.", "FIG.", "4 illustrates the frame portion 12 without the tablet inside (looking at the front).", "As can be seen from the Fig., it has a rectangular peripheral edge 22 that captures the edge of the tablet 16.Depending on the configuration, the edge structure 22 may be provided with built-in openings for different kinds of tablet access ports (for the purpose of pushing buttons on the tablet or accessing jacks, etc.).", "The frame 12 carries a first electrical adapter, indicated generally at 24 in FIGS.", "4 and 6, that provides the needed electrical connection to the tablet 16.The adapter 24 is “universal” in that it has a universal connector fitting 26 that would be shaped to fit a variety of different kinds of tablets (tablet variations are dictated by brand).", "Typically, and as a person skilled in the art would understand, the universal adapter 24 provides power and data connections for the tablet—i.e., power for the device's battery, etc., and data for network or Internet connections, if hard-wired connections are desired.", "The conductors for the universal adapter 24 run through a stem portion 28 (see FIG.", "6 of the universal adapter 24).", "FIG.", "5 illustrates the back-side or back plate 30 of the frame portion 12.It is surrounded by the edge 22 previously described.", "As is shown in FIG.", "5, it has an opening 30 for capturing the universal adapter 24 previously described.", "When all of these components are assembled together, it produces the frame portion of the docking station indicated in FIG.", "4 (the front side) and FIG.", "7 (the back side).", "Referring now to FIG.", "8, reference numeral 14 generally indicates the pedestal portion of the docking station 10.The pedestal portion includes an upper head portion, indicated generally at 36, and a lower base portion, indicated generally at 38.The head portion 36 carries a second universal adapter 40 that connects into a similar connector fitting in a recess of 42 of the first adapter 24.The first adapter 24 releasably rests on protrusions 44, 46 on head portion 36.It has a conventional catch 48 that allows adapter 24 (and therefore, frame 12) to be releasably connected to and from the pedestal portion 14 (via the head 36).", "An advantage to the design is that the portion fitting 40 adjacent the front face 52 of head portion 36 creates a reliable interface connection point for engagement/disengagement of the first universal adapter 24 (and frame portion 12) with the pedestal portion 14.The head portion 36 is designed to rotate at three physical positions.", "The first position is indicated by arrow 50 in FIG.", "9, which illustrates a circular rotation of the front face 52 of the head portion about an axis that would project normally out from face 52.When the frame portion 12 is mounted to the pedestal 14, this arrangement provides one degree of freedom of rotation that would allow the tablet 16 to be rotated between portrait and landscape orientations, if desired.", "Arrow 54 in FIG.", "10 points to another area designed to allow the head 36 to rotate up or down to rotationally lift or lower the screen of the tablet for vertical positioning, as desired.", "Finally, arrow 56 points to a last position for angularly rotating the head about a vertical or upright axis for angularly adjusting the tablet screen 16 from left-to-right, as desired.", "The physical structure of the above rotational connections can take different forms, using different types of pins or moldings that allow one part to rotate relative to another.", "In all cases, what is important about the design is that it allows three degrees of rotation without interfering with the wiring in the pedestal portion.", "FIGS.", "12 and 13 illustrate different possible rotational positions.", "In this last respect, FIG.", "11 illustrates base portion 38 with its cover plate 60 removed, thus exposing an electronics control board (ECB) 58 inside the base portion.", "A series of electrical connector fittings (USB, etc.)", "are electrically connected to the ECB 58 for providing data or power.", "These electrical signals are passed, via wiring, or a wiring harness, up through the body of the pedestal 14, which is hollow.", "The position of the wiring is schematically indicated by dashed line 63 in FIG.", "8.Referring to FIG.", "10, the pedestal 14 has openings 64, 66 that enable the wiring to pass through the head space, and through the physical zone of rotational connections described above.", "This allows rotation without stressing the wiring.", "The wiring connects to a board 67 upon which the second adapter fitting 40 rests.", "The board 67 provides the wiring connections to the fitting 40.Finally, the frame portion 12 could be releasably locked to the pedestal portion via a RFID lock if desired.", "The ECB 58 in the base portion has surface space for a RFID sensor 70 that could detect a wireless keycard, if desired.", "The sensor would activate locks on the head portion, upon detection of the keycard.", "It is to be appreciated that the foregoing description sets forth the best known examples and embodiments.", "It is not intended that any of the foregoing description be used to limit the scope of the patent protection.", "Instead, all patent protection is to be defined solely by the patent claim or claims that follow this description, the interpretation of which is to be made according to the legal rules of patent claim interpretation and the rules and regulations of the U.S. Patent and Trademark Office." ] ]
Patent_15875990
[ [ "UPDATING EXECUTION OF TASKS OF AN AGRICULTURAL PRESCRIPTION", "A method begins by a computing device allocating a plurality of tasks of an agricultural prescription for a farming geographic area to a fleet of farming equipment.", "While executing tasks of the plurality of tasks, the method continues with at least some of the fleet of farming equipment collecting task execution data.", "Based on the task execution data, the method continues with the computing device updating at least one of the agricultural prescription, the plurality of tasks, and the allocation of at least one task of the plurality of tasks." ], [ "1.A method for customizing an agricultural prescription based on data records and weather data for a geographic region, the method comprising: determining one or more time periods within an agricultural lifecycle set forth in an agricultural prescription for a geographic region; obtaining data records for the geographic region; wherein the data records are associated with the one or more time periods, and include one or more of: time stamped temperature levels, time stamped soil moisture levels, time stamped soil nutrient levels, or time stamped location information; obtaining weather data for the geographic region; based on the data records and the weather data, determining one or more growth factors for the one or more time periods; applying a deterministic function to the one or more growth factors to predict an accumulated growth metric for the geographic region; based on the accumulated growth metric for the geographic region, estimating a harvest-ready time for a probable harvest in the geographic region; and based on the harvest-ready time and the agricultural prescription, generating an updated agricultural prescription that prescribes steps for attaining the probable harvest at the harvest-ready time.", "2.The method of claim 1, wherein determining the one or more growth factors for the one or more time periods comprises determining, based on the data records for the geographic region, one or more of: soil moisture levels, soil nutrient levels, temperature levels, or sunlight intensity levels.", "3.The method of claim 1, wherein the deterministic function that is applied to the one or more growth factors to predict the accumulated growth metric for the geographic region is selected based on location information associated with the geographical region, a time of year, and an expected accuracy level; and wherein applying the deterministic function to the one or more growth factors to predict the accumulated growth metric for the geographic region comprises adjusting the one or more growth factors for the one or more time periods and applying the deterministic function to one or more adjusted growth factors until the expected accuracy level is achieved.", "4.The method of claim 1, wherein the agricultural prescription comprises one or more of: a planting plan; a tillage plan; a crop transportation plan; a speed plan; a fertilizing plan; a watering plan; a weeding plan; or a harvesting plan.", "5.The method of claim 1, wherein the agricultural prescription comprises task execution data which comprises at least one of: adherence information regarding performance of an allocated task of a plurality of tasks; farm equipment sensor data; farm equipment location information; or farm equipment operational data.", "6.The method of claim 5, further comprising: interpreting the task execution data in accordance with expected performance of the agricultural prescription to produce an actual performance level; determining whether the actual performance level meets the expected performance; and in response to determining that the actual performance level does not meet the expected performance, determining whether to update the agricultural prescription, the plurality of tasks, or an allocation of at least one task of the plurality of tasks.", "7.The method of claim 5, further comprising: interpreting the task execution data in accordance with expected performance of the agricultural prescription to determine whether one or more of: combine waste, planting errors, or application data meets the expected performance; and in response to determining that the one or more of: the combine waste, the planting errors, and the application data does not meet the expected performance, determining whether to update the agricultural prescription, the plurality of tasks, or an allocation of at least one task of the plurality of tasks.", "8.The method of claim 5, further comprising: updating the plurality of tasks by one or more of: adding a new task to the plurality of tasks; deleting an existing task of the plurality of tasks; or modifying a task of the plurality of tasks.", "9.The method of claim 5, further comprising: updating the agricultural prescription by one or more of: changing execution scheduling of one or more tasks of the plurality of tasks; adding, deleting, or modifying one or more planting steps; adding, deleting, or modifying one or more speed steps; adding, deleting, or modifying one or more fertilizing steps; adding, deleting, or modifying one or more watering steps; adding, deleting, or modifying one or more weeding steps; or adding, deleting, or modifying one or more harvesting steps.", "10.The method of claim 5, further comprising: updating an allocation of at least one task of the plurality of tasks by one or more of: reallocating an unexecuted task of the plurality of tasks from one piece of farming equipment to another piece of farming equipment of a fleet of farming equipment; reallocating a partially completed task of the plurality of tasks from the one piece of farming equipment to other piece of farming equipment of the fleet of farming equipment; or allocating a new task to one of the fleet of farming equipment.", "11.One or more non-transitory computer-readable storage media storing one or more computer instructions which, when executed by one or more processors, cause the one or more processors to perform: determining one or more time periods within an agricultural lifecycle set forth in an agricultural prescription for a geographic region; obtaining data records for the geographic region; wherein the data records are associated with the one or more time periods, and include one or more of: time stamped temperature levels, time stamped soil moisture levels, time stamped soil nutrient levels, or time stamped location information; obtaining weather data for the geographic region; based on the data records and the weather data, determining one or more growth factors for the one or more time periods; applying a deterministic function to the one or more growth factors to predict an accumulated growth metric for the geographic region; based on the accumulated growth metric for the geographic region, estimating a harvest-ready time for a probable harvest in the geographic region; and based on the harvest-ready time and the agricultural prescription, generating an updated agricultural prescription that prescribes steps for attaining the probable harvest at the harvest-ready time.", "12.The one or more non-transitory computer-readable storage media of claim 11, storing additional instructions which, when executed by the one or more processors, cause the one or more processors to perform: determining, based on the data records for the geographic region, one or more of: soil moisture levels, soil nutrient levels, temperature levels, or sunlight intensity levels.", "13.The one or more non-transitory computer-readable storage media of claim 11, wherein the deterministic function that is applied to the one or more growth factors to predict the accumulated growth metric for the geographic region is selected based on location information associated with the geographical region, a time of year, and an expected accuracy level; and wherein applying the deterministic function to the one or more growth factors to predict the accumulated growth metric for the geographic region comprises adjusting the one or more growth factors for the one or more time periods and applying the deterministic function to one or more adjusted growth factors until the expected accuracy level is achieved.", "14.The one or more non-transitory computer-readable storage media of claim 11, wherein the agricultural prescription comprises one or more of: a planting plan; a tillage plan; a crop transportation plan; a speed plan; a fertilizing plan; a watering plan; a weeding plan; or a harvesting plan.", "15.The one or more non-transitory computer-readable storage media of claim 11, wherein the agricultural prescription comprises task execution data which comprises at least one of: adherence information regarding performance of an allocated task of a plurality of tasks; farm equipment sensor data; farm equipment location information; or farm equipment operational data.", "16.The one or more non-transitory computer-readable storage media of claim 15, storing additional instructions which, when executed by the one or more processors, cause the one or more processors to perform: interpreting the task execution data in accordance with expected performance of the agricultural prescription to produce an actual performance level; determining whether the actual performance level meets the expected performance; and in response to determining that the actual performance level does not meet the expected performance, determining whether to update the agricultural prescription, the plurality of tasks, or an allocation of at least one task of the plurality of tasks.", "17.The one or more non-transitory computer-readable storage media of claim 15, storing additional instructions which, when executed by the one or more processors, cause the one or more processors to perform: interpreting the task execution data in accordance with expected performance of the agricultural prescription to determine whether one or more of: combine waste, planting errors, or application data meets the expected performance; and in response to determining that the one or more of: the combine waste, the planting errors, and the application data does not meet the expected performance, determining whether to update the agricultural prescription, the plurality of tasks, or an allocation of at least one task of the plurality of tasks.", "18.The one or more non-transitory computer-readable storage media of claim 15, storing additional instructions which, when executed by the one or more processors, cause the one or more processors to perform: updating the plurality of tasks by one or more of: adding a new task to the plurality of tasks; deleting an existing task of the plurality of tasks; or modifying a task of the plurality of tasks.", "19.The one or more non-transitory computer-readable storage media of claim 15, storing additional instructions which, when executed by the one or more processors, cause the one or more processors to perform: updating the agricultural prescription by one or more of: changing execution scheduling of one or more tasks of the plurality of tasks; adding, deleting, or modifying one or more planting steps; adding, deleting, or modifying one or more speed steps; adding, deleting, or modifying one or more fertilizing steps; adding, deleting, or modifying one or more watering steps; adding, deleting, or modifying one or more weeding steps; or adding, deleting, or modifying one or more harvesting steps.", "20.The one or more non-transitory computer-readable storage media of claim 15, storing additional instructions which, when executed by the one or more processors, cause the one or more processors to perform: updating an allocation of at least one task of the plurality of tasks by one or more of: reallocating an unexecuted task of the plurality of tasks from one piece of farming equipment to another piece of farming equipment of a fleet of farming equipment; reallocating a partially completed task of the plurality of tasks from the one piece of farming equipment to other piece of farming equipment of the fleet of farming equipment; or allocating a new task to one of the fleet of farming equipment." ], [ "<SOH> TECHNICAL FIELD OF THE INVENTION <EOH>This invention relates generally to computing systems utilized in agriculture and more particularly to utilization of computing systems to prescribe aspects of an agriculture life cycle to provide improved results of the agriculture life cycle." ], [ "<SOH> BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWING(S) <EOH>FIG.", "1 is a schematic block diagram of an embodiment of a computing system in accordance with the present invention; FIG.", "2 is a diagram illustrating an embodiment of a plurality of geographic regions in accordance with the present invention; FIG.", "3 is a diagram illustrating an embodiment of a plurality of sub-geographic regions in accordance with the present invention; FIG.", "4 is a schematic block diagram of an embodiment of a user device in accordance with the present invention; FIG.", "5 is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "6 is a diagram illustrating an embodiment of a drive path for an associated geographic region in accordance with the present invention; FIG.", "7 is a diagram illustrating a relationship between a user device and tracks along a drive path in accordance with the present invention; FIG.", "8 is a diagram illustrating an example of a structure of a data record in accordance with the present invention; FIG.", "9 is a schematic block diagram of an embodiment of an application unit and an associated storage unit in accordance with the present invention; FIG.", "10 is a diagram illustrating another embodiment of a drive path for an associated geographic region in accordance with the present invention; FIG.", "11 is a diagram illustrating a relationship between a user device, an actuator set, and tracks along a drive path in accordance with the present invention; FIG.", "12A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "12B is a schematic block diagram of an embodiment of a drive unit in accordance with the present invention; FIG.", "12C is a flowchart illustrating an example of collecting data to generate an agricultural prescription in accordance with the present invention; FIG.", "12D is a flowchart illustrating another example of collecting data to generate an agricultural prescription in accordance with the present invention; FIG.", "13A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIGS.", "13B-C are diagrams of agricultural prescription resource mapping in accordance with the present invention; FIG.", "13D is a flowchart illustrating an example of updating resource assignments in accordance with the present invention; FIGS.", "13E-F are flowcharts illustrating an example of updating execution of tasks of an agricultural prescription in accordance with the present invention; FIG.", "14A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "14B is a flowchart illustrating an example of identifying an unfavorable crop harvesting output level in accordance with the present invention; FIG.", "15A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "15B is a flowchart illustrating an example of identifying an unfavorable crop planting level in accordance with the present invention; FIG.", "16A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "16B is a flowchart illustrating an example of identifying an unfavorable applicant application level in accordance with the present invention; FIG.", "17A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "17B is a flowchart illustrating an example of generating a tillage agricultural prescription in accordance with the present invention; FIG.", "18A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "18B is a flowchart illustrating an example of generating a scouting agricultural prescription in accordance with the present invention; FIG.", "19A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "19B is a flowchart illustrating an example of generating an updated agricultural prescription based on forecasted weather conditions in accordance with the present invention; FIG.", "20A is a schematic block diagram of another embodiment of a user device in accordance with the present invention; FIG.", "20B is a schematic block diagram of an embodiment of an application processing module in accordance with the present invention; FIG.", "20C is a flowchart illustrating an example of opportunistic acquisition of location information enabling data collection to generate an agricultural prescription in accordance with the present invention; FIG.", "21A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "21B is a flowchart illustrating an example of generating a nitrogen application agricultural prescription in accordance with the present invention; FIG.", "22A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "22B is a flowchart illustrating an example of generating a harvest agricultural prescription in accordance with the present invention; FIG.", "23A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "23B is a flowchart illustrating an example of determining crop harvesting yield in accordance with the present invention; FIG.", "24A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "24B is a flowchart illustrating an example of optimizing crop harvesting yield in accordance with the present invention; FIG.", "25A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "25B is a diagram illustrating an example of correcting sensor data in accordance with the present invention; FIG.", "25C is a flowchart illustrating an example of improving accuracy of crop harvesting sensor data in accordance with the present invention; FIG.", "26A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "26B is a flowchart illustrating an example of improving accuracy of crop yield data in accordance with the present invention; FIG.", "27A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "27B is a flowchart illustrating another example of improving accuracy of crop yield data in accordance with the present invention; FIG.", "28A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; and FIG.", "28B is a flowchart illustrating an example of chain of custody crop tracking in accordance with the present invention.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS REFERENCE TO RELATED PATENTS This application claims the benefit under 35 U.S.C.", "§ 120 as a continuation of application Ser.", "No.", "14/810,809, filed Jul.", "28, 2015, which claims the benefit under 35 U.S.C.", "119(e) of provisional 62/046,346, entitled “UTILIZING SENSOR DATA TO GENERATE AN AGRICULTURAL PRESCRIPTION”, filed Sep. 5, 2014; and U.S.", "Provisional Application No.", "62/052,034, entitled “DETERMINING CROP HARVESTING YIELD”, filed Sep. 18, 2014, both of which are hereby incorporated herein by reference in their entirety and made part of the present U.S. Utility Patent Application for all purposes.", "TECHNICAL FIELD OF THE INVENTION This invention relates generally to computing systems utilized in agriculture and more particularly to utilization of computing systems to prescribe aspects of an agriculture life cycle to provide improved results of the agriculture life cycle.", "DESCRIPTION OF RELATED ART Agriculture is known to include cultivation of plants to sustain and enhance human life.", "The cultivation of plants includes executing numerous steps of the agriculture lifecycle, such as, land management, irrigation, fertilization, planting, and harvesting.", "Effectiveness of the agriculture lifecycle may depend upon process control of the execution of the numerous steps and further depend upon numerous conditions, such as, available sunlight, water availability, temperature ranges, wind speeds, soil type, soil nutrients, and other factors.", "Computing devices are known to gather data, store the data, process the data, and communicate the data.", "Examples of a computing device includes embedded farming equipment electronics, a smart phone, a tablet computer, a laptop computer, a personal computer, a storage server, and/or a data processing server.", "Basically, any device that includes a computing unit, one or more interfaces, and a memory system may be deemed a computing device.", "As is further known, computing devices may be utilized to gather data associated with the agriculture lifecycle and to process the gathered data.", "Such processed data may be utilized to understand cause and effect relationships associated with the effectiveness of the agriculture lifecycle.", "BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWING(S) FIG.", "1 is a schematic block diagram of an embodiment of a computing system in accordance with the present invention; FIG.", "2 is a diagram illustrating an embodiment of a plurality of geographic regions in accordance with the present invention; FIG.", "3 is a diagram illustrating an embodiment of a plurality of sub-geographic regions in accordance with the present invention; FIG.", "4 is a schematic block diagram of an embodiment of a user device in accordance with the present invention; FIG.", "5 is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "6 is a diagram illustrating an embodiment of a drive path for an associated geographic region in accordance with the present invention; FIG.", "7 is a diagram illustrating a relationship between a user device and tracks along a drive path in accordance with the present invention; FIG.", "8 is a diagram illustrating an example of a structure of a data record in accordance with the present invention; FIG.", "9 is a schematic block diagram of an embodiment of an application unit and an associated storage unit in accordance with the present invention; FIG.", "10 is a diagram illustrating another embodiment of a drive path for an associated geographic region in accordance with the present invention; FIG.", "11 is a diagram illustrating a relationship between a user device, an actuator set, and tracks along a drive path in accordance with the present invention; FIG.", "12A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "12B is a schematic block diagram of an embodiment of a drive unit in accordance with the present invention; FIG.", "12C is a flowchart illustrating an example of collecting data to generate an agricultural prescription in accordance with the present invention; FIG.", "12D is a flowchart illustrating another example of collecting data to generate an agricultural prescription in accordance with the present invention; FIG.", "13A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIGS.", "13B-C are diagrams of agricultural prescription resource mapping in accordance with the present invention; FIG.", "13D is a flowchart illustrating an example of updating resource assignments in accordance with the present invention; FIGS.", "13E-F are flowcharts illustrating an example of updating execution of tasks of an agricultural prescription in accordance with the present invention; FIG.", "14A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "14B is a flowchart illustrating an example of identifying an unfavorable crop harvesting output level in accordance with the present invention; FIG.", "15A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "15B is a flowchart illustrating an example of identifying an unfavorable crop planting level in accordance with the present invention; FIG.", "16A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "16B is a flowchart illustrating an example of identifying an unfavorable applicant application level in accordance with the present invention; FIG.", "17A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "17B is a flowchart illustrating an example of generating a tillage agricultural prescription in accordance with the present invention; FIG.", "18A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "18B is a flowchart illustrating an example of generating a scouting agricultural prescription in accordance with the present invention; FIG.", "19A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "19B is a flowchart illustrating an example of generating an updated agricultural prescription based on forecasted weather conditions in accordance with the present invention; FIG.", "20A is a schematic block diagram of another embodiment of a user device in accordance with the present invention; FIG.", "20B is a schematic block diagram of an embodiment of an application processing module in accordance with the present invention; FIG.", "20C is a flowchart illustrating an example of opportunistic acquisition of location information enabling data collection to generate an agricultural prescription in accordance with the present invention; FIG.", "21A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "21B is a flowchart illustrating an example of generating a nitrogen application agricultural prescription in accordance with the present invention; FIG.", "22A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "22B is a flowchart illustrating an example of generating a harvest agricultural prescription in accordance with the present invention; FIG.", "23A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "23B is a flowchart illustrating an example of determining crop harvesting yield in accordance with the present invention; FIG.", "24A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "24B is a flowchart illustrating an example of optimizing crop harvesting yield in accordance with the present invention; FIG.", "25A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "25B is a diagram illustrating an example of correcting sensor data in accordance with the present invention; FIG.", "25C is a flowchart illustrating an example of improving accuracy of crop harvesting sensor data in accordance with the present invention; FIG.", "26A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "26B is a flowchart illustrating an example of improving accuracy of crop yield data in accordance with the present invention; FIG.", "27A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; FIG.", "27B is a flowchart illustrating another example of improving accuracy of crop yield data in accordance with the present invention; FIG.", "28A is a schematic block diagram of another embodiment of a computing system in accordance with the present invention; and FIG.", "28B is a flowchart illustrating an example of chain of custody crop tracking in accordance with the present invention.", "DETAILED DESCRIPTION OF THE INVENTION FIG.", "1 is a schematic block diagram of an embodiment of a distributed computing system 10 that includes at least one wireless location network 18, one or more wireless communication networks 1, 2, etc., a network 24, an application unit 16, a storage unit 36, a plurality of user devices 14, and a plurality of user devices associated with geographic regions 1-R (e.g., user devices 1-1A, 1-1C, 1-2A, 1-2C, etc.", "associated with geographic region 1, user devices 2-1A, 2-1B, 2-1C, 2-2A, 2-2C, etc.", "associated with geographic region 2).", "Hereafter, the user devices associated with the geographic regions and the user devices 14 may be referred to interchangeably as the user devices.", "The components of the computing system 10 are coupled via the network 24, which may include one or more of wireless and/or wireline communications systems, one or more private communications systems, a public internet system, one or more local area networks (LAN), and one or more wide area networks (WAN).", "Each wireless communications network includes one or more of a public wireless communication system and a private wireless communication system and may operate in accordance with one or more wireless industry standards including universal mobile telecommunications system (UMTS), global system for mobile communications (GSM), long term evolution (LTE), wideband code division multiplexing (WCDMA), IEEE 802.11, IEEE 802.16.Each wireless communication network 1-R sends wireless communications signals 42 to the user devices and receives wireless communications signals 42 from the user devices to communicate data messages 44 and/or application messages 46.The user devices associated with the geographic regions may send and receive the wireless communications signals 42 directly between two or more user devices.", "Alternatively, or in addition to, the two user devices may communicate interface information 40 directly via a wireline interface between the two user devices.", "For instance, user device 2-1A communicates the interface information 40 with the user device 2-1B when the user device 2-1A and the user device 2-1B are operably coupled with the wireline interface.", "The wireless location network 18 includes one or more of a public wireless location system (e.g., global positioning satellite (GPS), a cellular network) and a private wireless location system (e.g., wireless beacon, a wireless local area network (WLAN)).", "The wireless location network 18 sends wireless location signals 38 to at least some of the plurality of user devices to enable determination of location information.", "The application unit 16 and storage unit 36 include a processing module (e.g., an application processing module) and memory to support execution of one or more applications (e.g., an agricultural lifecycle optimization application) and storage of information.", "Each user device may be a portable computing device (e.g., embedded farming equipment electronics, a farming equipment interface dongle, embedded vehicular electronics, a smart phone, a tablet computer, a laptop, a handheld computer, and/or any other portable device that includes a computing unit) and/or a fixed computing device (e.g., a desktop computer, a cable television set-top box, an application server, an internet television user interface and/or any other fixed device that includes a computing unit).", "Such a portable or fixed computing device includes one or more of a computing unit (e.g., providing processing module functionality), one or more wireless modems, sensors, and one or more user interfaces.", "The user device is discussed in greater detail with reference to FIG.", "4.Farming equipment (e.g., farm equipment) includes any machinery, apparatus, and/or tool associated with agriculture.", "For example, the farming equipment may include one or more of a tractor, a seed planter, a fertilizer dispenser (e.g., fertilizing equipment), a soil tiller, watering equipment, a combine, and a harvesting mechanism (e.g., harvesting equipment).", "As an example of user device implementation, user devices 1-1A, 1-2A, 2-1A, and 2-2A includes embedded farming equipment electronics associated with farm tractors.", "As another example, user devices 1-1C, 2-1C, 1-2C, and 2-2C include smart phones.", "As yet another specific example, user device 2-1B includes a tractor interface dongle.", "The user device 14, the application unit 16, and the storage unit 36, may be implemented in a variety of ways.", "For example, a first user device includes a computing unit, which includes the application unit 16.As another example, a second user device includes another computing unit, which includes the storage unit 36.As yet another example, a third user device includes yet another computing unit that includes the application unit 16 and the storage unit 36.As a still further example, a still further computing unit includes the application unit 16 and the storage unit 36.In general and with respect to optimization of the agricultural lifecycle, the computing system 10 supports at least five example functions: capturing data, analyzing data, producing an analysis summary, producing an agricultural prescription, and utilizing the agricultural prescription in the execution of the steps associated with the agricultural lifecycle.", "In accordance with these functions, agricultural prescriptions can be created that are relevant in relationship to likely planting lifecycles and may be utilized to enhance the effectiveness of the overall agricultural lifecycle.", "The first example function includes the computing system 10 capturing data.", "In this example, the user device 1-1A receives wireless location signals 38 and determines location information (e.g., location coordinates, a timestamp, identification of geographic region 1) therefrom.", "Having produced the location information, the user device 1-1A captures data associated with one or more steps of the agricultural lifecycle within the geographic region 1 and generates wireless communication signals 42 based on one or more of the data and the location information.", "As a specific example, the user device 1-1A traverses at least a portion of the geographic region 1 and captures sensor data as the captured data when the embedded control electronics for the farm tractor includes the user device 1-1A.", "Alternatively, the user device 1-1A stores at least a portion of the captured data in a local memory.", "The wireless communication signals 42 from user device 1-1A are received by a user device 1-1C.", "The user device 1-1C extracts the data from the received wireless communication signals 42 from the user device 1-1A and subsequently generates wireless communication signals 42 for transmission to the wireless communication network 1, where the wireless communication signals 42 are based on the data.", "The wireless communication network 1 receives the wireless communication signals 42 from the user device 1-1C and decodes the wireless communication signals 42 to reproduce the data.", "Having reproduced the data, the wireless communication network 1 sends a data message 44, via the network 24, to the storage unit 36, where the data message 44 includes the reproduced data.", "Alternatively, or in addition to, the user device 1-2A functions in a similar fashion as the user device 1-1A to capture further data within the geographic region 1, and to send, via a user device 1-2C, the wireless communication network 1, and the network, the further captured data to the storage unit 36.Having received one or more of the data message 44 from the user device 1-1A and another data message from the user device 1-2A, the storage unit 36 extracts the reproduced data from the data message 44 of the user device 1-1A and/or extracts the further captured data from the other data message 44 from the user device 1-2A to produce data from the geographic region 1.Having obtained the data from geographic region 1, the storage unit 36 generates data records based on the data from geographic region 1.Having generated the data records, the storage unit 36 facilitates storage of the data records in at least one of a local memory associated with the storage unit, the application unit, one or more user devices, another storage unit, and in a storage system.", "As a specific example, the storage unit 36 stores the data records in the local memory of the storage unit and sends, via the network 24, an information message 48 to a user device 14 associated with the geographic region 1, where the information message 48 includes the data record.", "In another example of operation of the capturing of the data, a user device 2-1A captures data associated with the geographic region 2 and sends interface information 40 to the user device 2-1B, where the interface information 40 includes the captured data associated with the geographic region 2 and location information associated with the user device 2-1A.", "Alternatively, or in addition to, the user device 2-1A stores at least a portion of the interface information 40 in a local memory of the user device 2-1A.", "The user device 2-1B sends, using the wireless communication signals 42, the captured data to the user device 2-1C.", "Alternatively, or in addition to, the user device 2-1B stores at least the portion of the interface information 40 in a local memory of the user device 2-1B.", "Alternatively, the user device 2-1B sends, using the wireless communication signals 42, the interface information 40 to the communication network 2.The user device 2-1C sends, using the wireless communication signals 42, the interface information 40 that includes the captured data to the wireless communication network 2 when the user device 2-1B sends the captured data to the user device 2-1C.", "The wireless communication network 2 sends the captured data, via the network 24, to the storage unit 36.Alternatively, the user device 2-1C sends, using the wireless communication signals 42, the captured data to the wireless communication network 1 where the wireless communication network 1 sends the captured data, via the network 24, to the storage unit 36.In a similar fashion, a user device 2-2A captures further data within the geographic region 2, and sends the captured further data, via one or more of the user device 2-2C, the wireless communication network 2, and the network 24, to the storage unit 36.The storage unit 36 receives data and/or captured further data from one or more of the user devices 2-1A and 2-2A to produce data from the geographic region 2.Having obtained the data from geographic region 2, the storage unit 36 generates data records based on the data from geographic region 2 and facilitates storage of the data records from the geographic region 2 in at least one of the local memory associated with the storage unit, the application unit, the one or more user devices, another storage unit, and in the storage system.", "As a specific example, the storage unit 36 stores the data records associated with the geographic region 2 in the local memory of the storage unit and sends, via the network 24, another information message 48 to another user device 14 associated with the geographic region 2, where the other information message 48 includes the data record associated with the geographic region 2.The second example function includes the computing system 10 analyzing the data.", "In an example of operation, the user device 14 associated with geographic region 1 issues an application message 46, via the network 24, to the application unit 16, where the application message 46 requests an analysis of the agricultural lifecycle for the geographic region 1.The application unit 16 obtains the information message 48 from the storage unit 36, where the information message 48 includes one or more of data records associated with the geographic region 1 and historical summaries associated with the geographic region 1.Such historical summaries include one or more of a result of a previous analysis, a summary of a previous analysis, and a summary of a previous agricultural prescription.", "Alternatively, or in addition to, the application unit 16 obtains another information message 48 from the storage unit 36, where the other information message 48 includes one or more data records associated with one or more other geographic regions.", "As a specific example, the application unit 16 obtains data records associated with geographic regions that are immediately proximally adjacent to the geographic region 1.Having obtained the one or more of the data records and the historical summaries, the application unit 16 performs one or more analysis functions on the data records and/or the historical summaries to produce an analysis.", "The analysis functions includes one or more of a filtering function, correlation function, a comparing function, a transformation function, a mathematical function, a logical function, an identification function, a listing function, a searching function, an estimation function, a probability density generating function, a trend analysis function, and any other function that may be utilized in assisting in analyzing the data records and/or the historical summaries to provide insights to improving the effectiveness of the steps of the agricultural lifecycle.", "As a specific example, the application unit 16 compares corn crop yield rates for the geographic region 1 and the geographic region 2 for a similar set of conditions (e.g., soil type, weather) and for differing approaches to the steps of the agricultural lifecycle to produce the analysis.", "Alternatively, or in addition to, the application unit 16 facilitates storage of the analysis in the storage unit 36 (e.g., to facilitate subsequent retrieval as history summaries).", "The third example function includes the computing system 10 producing the analysis summary.", "In an example of operation, having produced the analysis, the application unit 16 may obtain one or more further information messages 48 from the storage unit 36, where the one or more further information messages 48 includes one or more previous analysis summaries.", "Having obtained the further information messages 48, the application unit 16 summarizes the analysis to produce the analysis summary based on one or more of the analysis, the application message, and the previous analysis summaries.", "As a specific example, the application unit summarizes the analysis to produce a corn crop yield analysis summary for a previous year using a similar format in accordance with the previous analysis summaries, when the application message 46 from the user device 14 associated with the geographic region 1 requests a corn crop yield analysis for the previous year.", "Alternatively, or in addition to, the application unit 16 facilitates storage of the analysis summary in the storage unit 36 (e.g., to facilitate subsequent retrieval as history summaries).", "The fourth example function includes the computing system 10 producing the agricultural prescription.", "In an example of operation, having produced the analysis summary, the application unit 16 may obtain still further information messages 48 from the storage unit 36, where the still further information messages 48 includes one or more previous agricultural prescriptions.", "Having obtained the further information messages 48, the application unit 16 generates the agricultural prescription based on one or more of the analysis summary, the application message 46, and the previous agricultural prescriptions.", "The generating may include further analysis.", "As a specific example, the application unit 16 analyzes a previous agricultural prescription for the previous year, and the summary analysis for the previous year indicating results of utilizing the previous agricultural prescription, to produce a corn crop optimization prescription for a current year.", "For instance, the corn crop optimization prescription indicates which hybrid corn type to plant, when to plant, how to plant (e.g., including a density level of planting seeds), and a recommended procedure for harvesting.", "Having produced the agricultural prescription, the application unit 16 may send, via the network 24, yet another application message 46 to the user device 14 associated with the geographic region 1, where the yet another application message 46 includes the agricultural prescription.", "Alternatively, or in addition to, the application unit 16 facilitates storage of the agricultural prescription in the storage unit 36 (e.g., to facilitate subsequent retrieval as history summaries).", "The fifth example function includes the computing system 10 utilizing the agricultural prescription.", "In an example of operation, the application unit 16 generates another data message 44, where the other data message 44 includes the agricultural prescription.", "The agricultural prescription may be represented in a variety of formats including one or more of hypertext markup language, text, graphics, typographic maps, and a machine-readable format to facilitate some level of automation.", "For instance, the agricultural prescription includes the recommended steps of the agricultural lifecycle in a machine-readable format that is compatible with a particular set of farming machinery including one or more of farm tractors, soil maintenance machinery, fertilizer application machinery, planting machinery (e.g., a planter), and crop harvesting machinery (e.g., a combine).", "Having generated the other data message 44, the application unit 16 sends, via the network 24 and the wireless communication network 1 (e.g., using the wireless communication signals), the other data message 44 to the user device 1-1C.", "Having received the other data message 44, the user device 1-1C distributes the agricultural prescription to one or more of a user interface associated with the user device 1-1C (e.g., to display to an operator of farm machinery) and to user device 1-1A.", "Having received the agricultural prescription, the user device 1-1A extracts control information from the agricultural prescription.", "Having obtained the control information, the user device 1-1A outputs the control information to an actuator set associated with one or more varieties of farming machinery to facilitate the automation of the one or more steps of the agricultural lifecycle.", "The outputting of the control information to the actuator set is discussed in greater detail with reference to FIG.", "11.FIG.", "2 is a diagram illustrating an embodiment of a plurality of geographic regions, where one or more of the geographic regions include the geographic regions 1-R of FIG.", "1.The plurality of geographic regions may include any number of geographic regions spanning relatively small areas (e.g., a few acres per region), relatively large areas (e.g., tens of thousands of acres or more per region), or any size in between.", "Two or more geographic regions may be associated with common characteristics.", "For example, each geographic region may include a common geographic region size or a unique geographic region size.", "Two or more geographic regions may overlap such that a common portion is included in each of the two or more geographic regions.", "Each geographic region may include two or more sub-geographic regions.", "Each geographic region may be associated with region characteristics.", "The region characteristics include one or more of a natural water supply level, a man-made irrigation water supply level, an average number of sun-days, an average sun intensity level, a soil type, a soil nutrient level, a previous utilization history, a crop yield rate, an insect affect level, an average altitude level, and average temperature level, and any other metric associated with characteristics that may affect the efficiency of the agricultural lifecycle.", "Two or more regions may share common and/or similar region characteristics.", "For example, adjacent geographic regions have a higher probability of sharing more common region characteristics than non-adjacent geographic regions.", "As another example, a series of geographic regions that include a common waterway (e.g., a lake, a river) may share more common region characteristics.", "Each geographic region may be associated with varying groups of user devices utilized in the primary steps of the computing system 10 of FIG.", "1.For example, a common first user device is associated with operation within geographic regions 1 and 2.As another example, a unique second user device is associated with operation within geographic region 2 and a unique third user device is associated with operation within geographic region 3.FIG.", "3 is a diagram illustrating an embodiment of a geographic region divided into any number of sub-geographic regions.", "Hereafter, a sub-geographic region may be referred to interchangeably as a geographic sub-region.", "For example, geographic region 1 includes geographic sub-regions 1-1, 1-2, 1-3, 1-4, etc.", "Each geographic sub-region may include any number of user devices that operate within the sub-region.", "For example, the geographic sub-region 1-1 includes a user device 1-1A and a user device 1-1C; the geographic sub-region 1-2 includes a user device 1-2A and a user device 1-2C; the geographic sub-region 1-3 includes a user device 1-3A, a user device 1-3B operably coupled with the user device 1-3A to exchange interface information 40, and a user device 1-3C; and the geographic sub-region 1-4 includes a user device 1-4A and a user device 1-4C.", "As another example, each geographic sub-region may include a common group of user devices such that the common group of user devices traverses each geographic sub-region of the geographic region.", "FIG.", "4 is a schematic block diagram of an embodiment of a user device (e.g., 12, 14 or any other user device).", "The user device includes a user interface output 50, a user interface input 52, one or more sensors 1-S, an interface 54, a computing unit 26, one or more wireless communications modems 1-M, and at least one wireless location modem 56.The user interface output 50 may include a single interface output device or a plurality of interface output devices to present user output 60.The interface output device may include one or more of a display, a touch screen, a speaker, an earpiece, a motor, an indicator light, a light emitting diode (LED), a transducer, and a digital indicator.", "For instance, the interface output device includes a color touch screen display capable of rendering static images and/or full-motion video.", "The user interface input 52 may include a single interface input device or a plurality of interface input devices to capture user input 62.The interface input device includes one or more of a touch screen sensor array, a keyboard, a microphone, a fingerprint reader, a trackball, a mouse sensor, an image sensor, a pushbutton, and a selector switch.", "For instance, the interface input device includes a touch screen sensor array associated with the color touch screen display.", "Each sensor includes capabilities for sensing one or more of a magnetic field (e.g., a compass), motion (e.g., an accelerometer), temperature, pressure, altitude, humidity, moisture, an image, visible light, infrared light, an electromagnetic field, ultrasonic sound, weight, density, a chemical type, fluid flow volume, execution of a step of the agricultural lifecycle, a stream of images (e.g., capture video), biometrics, proximity, capacitance, gases, radiation, pathogens, light levels, bio hazards, DNA, wind speed, wind direction, and characteristics of an object to support object detection and/or object identification.", "The sensors 1-S output sensor data 1-S to the computing unit 26.For example, a first sensor outputs sensor data 1 that includes a video stream when the first sensor includes an image capture device.", "As another example, a second sensor outputs sensor data 2 that includes a moisture level indicator when the second sensor includes a moisture detector.", "As yet another example, a third sensor outputs sensor data 3 that includes tractor pitch, tractor yaw, tractor roll, tractor velocity, tractor acceleration, tractor position, tractor inclination, tractor tilt, tractor orientation tractor impact (e.g.", "shock) when the third sensor includes the accelerometer and the embedded control electronics of a farming tractor includes the user device.", "The interface 54 provides an external wireline interface to the computing unit such that interface information 40 may be communicated with one or more other devices operably coupled to the interface 54.Each device includes one or more other user devices.", "For example, another user device is associated with embedded sensor and control electronics of a farming planting mechanism.", "As another example, the other user device is associated with embedded control electronics of a farming fertilizing mechanism.", "As yet another example, the other user device is associated with embedded control electronics of a farming harvesting mechanism.", "As a still further example, the other user device is associated with the embedded control electronics of the farming tractor.", "The interface 54 may operate in accordance with one or more industry interface protocol standards such as on-board diagnostics (OBD), controller area network (CAN), or any other industry interface protocol standard.", "For instance, the interface operably couples to a CAN interface of a farming tractor such that the interface information 40 may be exchanged between the computing unit 26 and the embedded control electronics of the farming tractor.", "The interface information 40 includes one or more of further sensor data, an agricultural prescription, and control information (e.g., one or more steps of an agricultural lifecycle).", "As a specific example, the interface 54 couples the computing unit 26 to the farming fertilizing mechanism such that the computing unit 26 receives sensor data from a sensor array associated with the farming fertilizing mechanism that monitors fertilization steps of the agricultural lifecycle.", "Each wireless communication modem 1-M may include a single wireless transceiver or a plurality of wireless transceivers.", "Alternatively, or in addition to, each communication modem may include one or more wireless transmitters.", "The wireless transceiver and/or transmitter encodes wireless messages to produce wireless communication signals and the wireless transceiver further receives other wireless communication signals for decoding into corresponding wireless messages.", "The wireless transceiver and/or transmitter may operate in accordance with one or more wireless industry standards including universal mobile telecommunications system (UMTS), global system for mobile communications (GSM), long term evolution (LTE), wideband code division multiplexing (WCDMA), IEEE 802.11, IEEE 802.16, and Bluetooth.", "For example, the wireless communication modem 1 encodes the wireless messages 1 for transmission as Bluetooth wireless communication signals to a local user device and the wireless communication modem 2 encodes the wireless messages 2 for transmission as LTE wireless communication signals to a wireless communication network.", "The wireless location modem 56 may include one or more of a single wireless location receiver, a single wireless location transceiver, a plurality of wireless location receivers, and a plurality of wireless location transceivers.", "The wireless location receiver and wireless location transceiver may operate in accordance with one or more wireless location technologies including GPS, WiFi, angle of arrival, time difference of arrival, signal strength, and beaconing to produce location information 64.The computing unit 26 includes an application processing module 34, a memory 58, and one or more internal interfaces to one or more of the user interface output 50, the user interface input 52, the sensors 1-S, the interface 54, the wireless communication modems 1-M, and the wireless location modem 56.The memory 58 provides a non-transitory computer readable storage medium that stores operational instructions that are executed by the processing module 34.The memory 58 may include a single memory device or a plurality of memory devices.", "Each memory device is associated with a memory type including one or more of a read-only memory, random access memory, volatile memory, non-volatile memory, cache memory, and/or any device that stores digital information.", "Each memory device may be implemented utilizing one or more technologies including static random access memory (SRAM), dynamic random access memory (DRAM), NAND flash memory, magnetic memory (e.g., a hard disk), and optical memory (e.g., an optical disc) that stores digital information.", "The memory device may be removable (e.g., a universal serial bus flash drive) to facilitate transfer of data between the computing unit 26 and other entities that may operably coupled with the removable memory device.", "FIG.", "5 is a schematic block diagram of another embodiment of a computing system that includes the wireless location network 18, the wireless communication network 1, the network 24, the application unit 16, the storage unit 36, and the user device 14 that is associated with geographic region 1-1.Within the geographic region 1-1 are the user device 1-1A (e.g., embedded control electronics of a farming tractor) and the user device 1-1C (e.g., a smart phone utilized by an operator of the farming tractor).", "In an example of operation of performing one of the five example functions, the user device 1-1A determines location information based on receiving wireless location signals 38 from the wireless location network 18 and captures sensor data (e.g., farming tractor accelerometer data, soil moisture levels, soil chemical content, etc.)", "along a drive path 1-1 for at least a portion of the geographic region 1-1.The drive path 1-1 includes a geographic path of the user device 1-1A when the user device 1-1A operates within the geographic region 1.The drive path may include two or more sub-drive paths.", "For example, a first sub-drive path traverses the geographic region 1-1 from west to east and a second sub-drive path traverses the geographic region 1-1 from east to west.", "The user device 1-1A may monitor the drive path (e.g., passively monitoring along a path taken by the farming tractor) or may provide the drive path (e.g., where an agricultural prescription includes control information to invoke operation of the farming tractor along the drive path).", "The drive path 1-1 may be obtained by the user device 1-1A in a variety of ways including one or more of determining a specific drive path in accordance with the agricultural prescription 80, utilizing a predetermined drive path (e.g., the drive path for geographic region 1-1 from a list), generating a random drive path, utilizing a previous drive path associated with geographic region 1-1 (e.g., obtaining a historical summary), and receiving the agricultural prescription 80 that includes control information associated with the drive path.", "As a specific example, the user device 1-1A utilizes the drive path 1-1 from the agricultural prescription 80 while an associated farming tractor and tilling machinery is tilling the soil of at least a portion of the geographic region 1-1.Having captured the sensor data, the user device 1-1A sends, using, for example, Bluetooth wireless communication signals, the captured sensor data to the user device 1-1C.", "The user device 1-1C sends, utilizing, for example, long-term evolution (LTE) wireless communication signals, the captured sensor data 70 via the wireless communication network 1 and the network 24 to the storage unit 36.The application processing module 34 of the storage unit 36 processes the captured sensor data 70 to produce data records 74 for storage in the memory of the storage unit 36.Alternatively, a removable memory of the user device 1-1A is utilized to temporarily store the captured sensor data 70.The removable memory is operably coupled to the storage unit 36 to facilitate transfer of the captured sensor data 70 to the application processing module 34 of the storage unit 36.For example, the removable memory device is directly interfaced to the storage unit 36.As another example, the removal memory device is interfaced to the user device 14 associated with the geographic region 1-1 and the user device 14 facilitates sending, via the network 24, the captured sensor data 70 to the storage unit 36.The application processing module 34 of the user device 14 associated with the geographic region 1-1 receives a user input to invoke a request for an analysis and generation of an agricultural prescription 80.The application processing module 34 of the user device 14 generates guidance 72 based on the request and other desired characteristics (e.g., a crop list, a time frame, equipment availability, chemical availability, and soil management operational ranges available) of the agricultural prescription 80 for the geographic region 1-1.The user device 14 sends, via the network 24, the guidance 72 to the application unit 16.The application processing module 34 of the application unit 16 obtains the data records 74 for the geographic region 1-1 from the storage unit 36 based on the guidance 72.The application processing module 34 of the application unit 16 may further obtain historical summaries 76 with regards to the geographic region 1-1 based on the guidance 72.Having obtained the guidance 72, the data records 74, and/or the historical summaries 76, the application processing module 34 of the application unit 16 produces an analysis based on the data records 74 and/or the historical summaries 76.The application processing module 34 of the application unit 16 processes the analysis in accordance with the guidance 72 and/or the historical summaries 76 to produce an analysis summary 78.The application processing module 34 of the application unit 16 facilitates storage of the analysis summary 78 by the storage unit 36 to enable subsequent recovery of the historical summaries 76 that includes the analysis summary 78.Having produced the analysis summary 78, the application processing module 34 of the application unit 16 processes the analysis summary 78 in accordance with the guidance 72 and the historical summaries 76 to produce the agricultural prescription 80.The agricultural prescription 80 may further include a plurality of steps, where each step includes one or more actions, and for each action, one or more required preconditions to execute the action.", "Such steps may be executed in parallel, in series, and in a combination in accordance with the preconditions for execution.", "The preconditions for execution of the action includes required conditions to enable execution of the action (e.g., when to execute the action) including one or more of a current date match, a current date within a date range, a time within a time range, a current data sensor value within a desired range (i.e., a current temperature within a temperature range), an actuator readiness state, distance from a previously executed step (i.e., seed dispensing population of seeds per acre), and elapsed time since a previously executed step).", "For example, a precondition for planting a short growing seed at a later date has occurred within a growing season.", "Each action includes what to do and how to do it (e.g., when to do it is a precondition).", "As such, each action includes one or more of dispensing particular one or more materials (i.e.", "a gas, a liquid, a slurry, a solid), how to dispense the material (i.e., distance between dispensing points, distance between parallel dispensing tracks), collect sensor data, and manipulate another object (i.e.", "management practices including one or more of: tilling, irrigation control, sunlight control), activate a variant of an electromagnet field).", "The liquids include chemical compounds such as fertilizers and pesticides.", "The pesticides include one or more of insecticides (e.g., insect killers), herbicides (e.g., weed killers), and fungicides (e.g., to kill or inhibit fungi).", "The solids include one or more of seed, fertilizer powder, and manure.", "The seeds include a plurality of hybrid seed types and may vary from growing season to growing season.", "Having produced the agricultural prescription 80, the application processing module 34 of the application unit 16 sends, via the network 24, one or more of the analysis summary 78 and the agricultural prescription 80 to the user device 14.The application processing module 34 of the application unit 16 may further send the agricultural prescription 80, via the network 24 and the wireless communication network 1, to the user device 1-1C for utilization in performing of one or more steps of the agricultural lifecycle in accordance with the agricultural prescription 80.For example, the user device 1-1C displays a portion of the agricultural prescription 80 and sends control information of the agricultural prescription, via wireless signals 42, to the user device 1-1A to automate a portion of the execution of at least some of the steps of the agricultural lifecycle.", "For the example, the user device 1-1A issues control information to a set of actuators to dispense fertilizer in accordance with the agricultural prescription 80.For instance, to control dispensing a specified volume of liquid fertilizer in a specified date range in a specified geometric pattern for at least a portion of the geographic region 1-1 as the user device 1-1A versus the drive path 1-1.FIG.", "6 is a diagram illustrating an embodiment of a drive path 1-1 for an associated geographic region 1-1.In an example of operation, the user device 1-1A of FIG.", "1 traverses the drive path 1-1 when executing steps of an agricultural lifecycle.", "The traversing of the drive path 1-1 may be in accordance with an agricultural prescription.", "The drive path 1-1 includes a plurality of corresponding drive paths 1-1-1, 1-1-2, 1-1-3, 1-1-4, etc.", "Each corresponding drive path may be associated with a portion of the overall drive path such that the corresponding drive path is associated with favorable attributes.", "Such favorable attributes include one or more of minimizing waste by including fewer turnaround sections or deleting sections that link one corresponding drive path to another, minimizing fuel usage, minimizing soil erosion, maximizing crop yield, and maximizing overall efficiency of executing one or more steps of an agricultural lifecycle.", "For example, drive path 1-1-1 extends from a western edge of the geographic region 1-1 to an eastern edge of the geographic region 1-1 such that a farming tractor traversing the drive path 1-1-1 minimizes an amount of time to cover acreage associated with drive path 1-1-1 (e.g., driving in a substantially straight line).", "The user device 1-1A includes an array of sensors that are utilized along the drive path 1-1 to capture sensor data in accordance with a data capture scheme.", "The agricultural prescription may include the data capture scheme.", "The data capture scheme includes one or more of where to capture sensor data (e.g., coordinates, distance between capturing), when to capture sensor data (e.g., how often, precondition trigger), which sensors to capture sensor data from (e.g., selecting particular sensors based on a step of an agricultural lifecycle), and how to capture the sensor data (e.g., instantaneous sample, average sample, another mathematical distribution applied to sample data).", "The user device 1-1A may utilize the array of sensors to capture the sensor data for as many as each pass along the drive path 1-1 when operating within the geographic region 1-1 to execute at least some of the steps of the agricultural lifecycle.", "For example, the user device 1-1A captures sensor data while one or more of the following steps of the agricultural lifecycle are executed: initiating a planting cycle by tilling soil, applying fertilizer, applying pesticide, planting a primary crop, simultaneously applying fertilizer while planting the primary crop, planting a cover crop (e.g.", "utilized to minimize soil erosion and enhance soil nutrients), managing irrigation, harvesting according to a time schedule, harvesting based on detecting a crop condition trigger (e.g., crop moisture content), tilling the soil after harvesting, and applying fertilizer after harvesting.", "The capturing of the sensor data may be unique for each of the corresponding drive paths.", "For example, the data capture scheme indicates to capture the sensor data from all sensors along the drive path 1-1-1 every one tenth of an inch to produce data capture points 1,1, 1,2, 1,3, 1,4, etc.", "When capturing the sensor data at periodic distance intervals, one of the data sensors may be utilized to measure the distance between data capture points to trigger capture of a next set of sensor data at a next data capture point.", "As another example, the data capture scheme indicates to capture the sensor data from sensors 1, 3, 5, and 7 along the drive path 1-1-2 every two seconds.", "As yet another example, the data capture scheme indicates to capture the sensor data from sensors 2 and 4 along the drive path 1-1 when sensor data from sensor 1 is interpreted to detect that a particular chemical density level is less than a low chemical density threshold level.", "FIG.", "7 is a diagram illustrating a relationship between the user device 1-1A and tracks 1-7 along the drive path 1-1-1.The user device 1-1A includes the application processing module 34, an array of sensors 1-7, sensor L, sensor R, and sensor ALL to capture corresponding sensor data 70 along the drive path 1-1-1 as the user device 1-1A traverses the drive path 1-1-1 in accordance with a velocity 1-1-1.The velocity 1-1-1 may be established as at least one of a random velocity, a predetermined velocity, and an instantaneous velocity in accordance with a velocity schedule.", "An agricultural prescription may include the velocity schedule for each corresponding drive path or portion thereof.", "The drive path 1-1-1 is associated with the tracks 1-7 and may include further tracks.", "Each track is a virtual path substantially parallel with the drive path 1-1-1.A center track (e.g., track 4) may further align with the drive path 1-1-1 and each other track runs in parallel to the center track, where each track is separated from another track by a potentially unique distance d (e.g., different distances between different tracks in a typical range of a few centimeters to many meters).", "For example, track 3 is separated from track 4 by distance d3-4 of 8 inches and track 4 is separated from track 5 by distance d4-5 of 20 inches.", "The agricultural prescription may include a number of tracks, each of the distances that separate the tracks, and a track to sensor mapping.", "Each sensor is associated with one or more tracks.", "For example, sensor 1 is associated with track 1, sensor 2 is associated with track 2, sensor 3 is associated with track 3, etc.", "through sensor 7 is associated with track 7; sensor L is associated with tracks 1-4; sensor R is associated with tracks 4-7; and sensor ALL is associated with tracks 1-7.Each sensor may include capabilities to sense one or more attributes associated with one or more of the tracks in accordance with the track mapping.", "For example, sensors 1-7 include image sensors to detect and enable identification of objects (e.g., desired and undesired) along tracks 1-7, sensor L includes an ultrasonic sensor to detect objects associated with tracks 1-4, sensor R includes an ultrasonic sensor to detect objects associated with tracks 4-7, and sensor ALL includes an accelerometer to provide inertia information with regards to a farming tractor associated with the user device 1-1A (e.g., to enable precision location determination).", "The application processing module 34 captures the sensor data 70 from the array of sensors from time to time in accordance with a data capture scheme.", "The application processing module 34 processes the sensor data 70 in accordance with a sensor data processing scheme.", "The agricultural prescription may include the sensor data processing scheme.", "The application processing module 34 obtains the sensor data processing scheme by at least one of accessing a predetermination, initiating a query, receiving a query response, receiving the agricultural prescription, and determining the agricultural prescription.", "The sensor data processing scheme includes one or more of locally storing at least a portion of the sensor data, outputting at least some of the sensor data, identifying a portion of the sensor data for analysis, analyzing the identified portion of the sensor data to produce an analysis, summarizing the analysis to produce an analysis summary, and generating an updated agricultural prescription.", "As a specific example of capturing the sensor data 70, the application processing module 34 captures the sensor data 70 from the array of sensors at a data capture point 1,1 for each of the tracks 1-7, where the distance between tracks is 8 inches; captures the sensor data 70 from the array of sensors at a data capture point 1, 2 for each of the tracks 1-7, where the distance between tracks is adjusted to 6 inches, from sensor L, from sensor R, and from sensor ALL; captures the sensor data 70 from the array of sensors at a data capture point 1, 3 for each of the tracks 1-7, where the distance between tracks is maintained at 6 inches, and the velocity 1-1-1 is suggested from 8 miles per hour (MPH) to 11 MPH; etc.", "FIG.", "8 is a diagram illustrating an example of a structure of a geographic region 1-1 data record, where the data records 74 may include the geographic region 1-1 data record.", "The geographic region 1-1 data record includes a plurality of drive path data records 1-1-1, 1-1-2, 1-1-3, etc.", "Each drive path data record is associated with a plurality of corresponding drive paths of a drive path associated with the geographic region 1-1.Each drive path data record includes data capture point data records.", "For example, the drive path 1-1-1 data record includes data capture point data records for data capture points 1,1, 1,2, 1,3, 1,4, etc.", "Each data capture data record includes the sensor data 70 for a sensor array corresponding to a user device associated with capture of the sensor data.", "For example, the data capture point data records for the drive path 1-1-1 data record includes sensor data 1-8, sensor data L, sensor data R, sensor data ALL, and may include further data associated with data capture point 1,1.The further data may include one or more of a timestamp corresponding to capturing of the sensor data, a timestamp corresponding to receiving of the captured sensor data, location information associated with the data capture point, an identifier of a user device associated with the sensor array, identifiers for each sensor of the sensor array, an identifier associated with another user device that is associated with the user device, an identifier of the geographic region, an identifier of the drive path data record, an identifier of the data capture point, a data owner identifier, an access control list, security credentials, security information (e.g., a signed certificate, an encryption key, an encryption key seed), and any other data to facilitate optimization of an agricultural lifecycle.", "FIG.", "9 is a schematic block diagram of an embodiment of the application unit 16 and of the storage unit 36, where the application unit 16 and the storage unit 36 include corresponding application processing modules 34 and may include the memory 58.Alternatively, a single computing device may include each application processing module 34 and each memory 58.The application processing module 34 of the application unit 16 includes an analyzing module 81, an analysis summary generating module 82, and a prescription generating module 84.The application processing module 34 of the storage unit 36 includes a data collecting module 86 and a history summarizing module 88.The application unit 16 and storage unit 36 perform at least some steps associated with the five example functions of the computing system 10.In an example of operation, the data collecting module 86 receives sensor data 70 from one or more user devices associated with a geographic region of a plurality of geographic regions.", "The data collecting module 86 generates one or more data records 74 based on the sensor data 70 and stores the one or more data records 74 in the memory 58 of the storage unit 36.The analyzing module 81 receives guidance 72 from a user device (e.g., the user device 14 of FIG.", "1) associated with the geographic region.", "For example, the guidance 72 includes a request for an analysis and conditions of the analysis.", "The analyzing module 81 obtains data records 74 from the data collecting module 86 based on the guidance 72 and may further obtain a historical summary 76 from the history summarizing module 88 based on the guidance 72.Hereafter, the historical summary 76 may be interchangeably referred to as a history summary.", "For example, the analyzing module 81 issues a data records request to the data collecting module 86 with regards to the geographic region and receives the data records 74 from the data collecting module 86, where the received data records 74 are associated with the geographic region and adjacent geographic regions to the geographic region.", "As another example, the analyzing module 81 issues a history summary request to the history summarizing module 88 and receives the historical summary 76 with regards to the geographic region and the adjacent geographic regions from the history summarizing module 88.Having obtained the data records 74 and the historical summary 76, analyzing module 81 analyzes one or more of the data records 74 and the historical summary 76 to produce an analysis 90 in accordance with the guidance 72.For example, the analyzing module 81 identifies results from the data records 74 and correlates the results to specific steps of an agricultural lifecycle of the historical summary 76 to produce the analysis 90, where the analysis 90 indicates results and associated steps.", "The analysis summary generating module 82 obtains another historical summary 76 from the history summarizing module 88, where the other historical summary 76 includes a previous analysis summary associated with the geographic region.", "Having received the historical summary 76, the analysis summary generating module 82 summarizes the analysis 90 in accordance with one or more of the guidance 72 and the historical summary 76 to produce an analysis summary 78.For example, the analysis summary generating module 82 determines probabilities of favorable results associated with the steps based on previous sets of results and steps.", "The history summarizing module 88 may obtain the analysis summary 78 and process the analysis summary 78 to produce a further historical summary 76 for storage in the memory 58 of the storage unit 36.The prescription generating module 84 obtains yet another historical summary 76 from the history summarizing module 88, where the yet another historical summary 76 may include one or more previous agricultural prescriptions associated with the geographic region and/or agricultural prescriptions associated with the adjacent geographic regions.", "Having received the analysis summary 78 and the yet another historical summary 76, the prescription generating module 84 generates an agricultural prescription 80 for the geographic region based on one or more of the analysis summary 78, the yet another historical summary 76, and the guidance 72.For example, the prescription generating module 84 utilizes the probabilities of favorable results associated with the steps to recommend steps of the agricultural lifecycle associated with the geographic region and in accordance with the guidance 72 (e.g., for a specific desired crop type).", "The agricultural prescription 80 may include one or more of steps, actions associated with each step, and preconditions for each action.", "The prescription generating module 84 outputs the agricultural prescription 80 which may include sending the agricultural prescription 80 to the history summarizing module 88.When receiving the agricultural prescription 80, the history summarizing module 88 processes the agricultural prescription 80 to produce an updated historical summary 76 for storage in the memory 58.FIG.", "10 is a diagram illustrating another embodiment of the drive path 1-1 for associated geographic region 1-1.The user device 1-1A captures sensor data at the plurality of data capture points along each associated drive path of the drive path 1-1 and provides action data along at least some of the associated drive paths.", "The user device enables execution of the action data along each associated drive path in accordance with an agricultural prescription.", "The action data includes one or more steps of an agricultural lifecycle, and may further include actions and associated preconditions for each action.", "For example, an action may include depositing a specified volume of liquid fertilizer along the drive path 1-1-1 at specific intervals.", "As another example, the action may include planting seeds of a desired crop at a specific soil depth at specified intervals along the drive path 1-1-2.For instance, a specified average number of seeds are deposited along the drive path 1-1-2 in accordance with action data 2, 4 followed by depositing further seeds along the drive path 1-1-2 in accordance with action data 2, 3 etc.", "FIG.", "11 is a diagram illustrating a relationship between the user device 1-1A, an actuator set 92, and the tracks 1-7 along the drive path 1-1-1.In an embodiment, the actuator set 92 includes a set of actuators 1-7, actuator L, actuator R, and actuator ALL.", "Each actuator is operable to perform an action in accordance with control information 94 including one or more of dispensing fluid (e.g., fertilizer, pesticide, fungicide), dispensing a solid (e.g., planting a seed), and manipulating soil (e.g., tilling).", "An agricultural prescription 80 includes the control information 94 that includes the actions of the planting.", "The user device 1-1A includes the sensor array of FIG.", "7 and the application processing module 34 of FIG.", "7.The control information 94 further includes one or more instructions with regards to implementation of actions performed by the actuators.", "The instructions includes one or more of setting a distance d between the tracks, planting a seed at a specified planting depth, dispensing a specified volume of a liquid within a linear distance along a track, setting a velocity 1-1-1 of traversing of the drive path 1-1-1 in accordance with a velocity schedule, modifying the velocity 1-1-1 based on real-time sensor data, and utilizing one or more sensors to detect preconditions to enable execution of one or more actions.", "The user device 1-1A and the actuator set 92 share a common implementation association.", "For example, embedded control electronics of a farming tractor includes the user device 1-1A and a farming planting mechanism, propelled by the farming tractor, includes the actuator set 92, where the actuator set 92 facilitates actions associated with planting along the drive path 1-1-1.Each actuator may be associated with one or more of the tracks 1-7.For example, actuator 1 is associated with track 1, actuator 2 is associated with track 2, etc.", "through actuator 7 is associated with track 7, actuator L is associated with tracks 1-4, actuator R is associated with tracks 4-7, and actuator ALL is associated with tracks 1-7.For example, actuators 1-7 include planting actuators, actuator L includes a mechanism to simultaneously adjust a position of actuators 1-4 (e.g., lift left, lower left), actuator R includes a mechanism to simultaneously adjust a position of actuators 4-7 (e.g., lift right, lower right), and actuator ALL includes a mechanism to simultaneously adjust a position of actuators 1-7 (e.g., lift all, lower all).", "In an example of operation, the application processing module 34 of the user device 1-1A extracts the control information 94 from the received agricultural prescription 80 and activates the actuator set 92 with the control information 94.As the user device 1-1A and the actuator set 92 traverses the drive path 1-1-1 at velocity 1-1-1, the actuator set 92 performs the actions of the control information 94 (e.g., plants seeds along the tracks) in accordance with a plurality of action data 1,1, 1,2, 1,3, 1,4, etc., and the application processing module 34 captures sensor data 70 from the array of sensors at data capture points 1,1, 1,2, 1,3, 1,4, etc.", "The application processing module 34 may update the control information 94 based on the captured sensor data 70.For example, the application processing module modifies a planting depth of the control information 94 based on a moisture sensor data value and in accordance with the agricultural prescription 80.FIG.", "12A is a schematic block diagram of another embodiment of a computing system that includes the wireless location network 18 of FIG.", "5, a geographic region 2-1, the wireless communication network 2 of FIG.", "1, the network 24 of FIG.", "1, the user device 14 of FIG.", "5, the application unit 16 of FIG.", "5, and the storage unit 36 of FIG.", "5.The geographic region 2-1 includes the user devices 2-1A, 2-1B, and 2-1C of FIG.", "5, where the user device 2-1A traverses the drive path 2-1 of FIG.", "5.Each of the user device 14, the application unit 16, and the storage unit 36 include the application processing module 34 of FIG.", "5.The storage unit 36 further includes the memory 58 of FIG.", "5.The computing system is operable to collect data to generate an agricultural prescription for the geographic region 2-1.In an example of operation of the collecting of the data to generate the agricultural prescription, the user device 2-1B obtains one or more prescriptions associated with the geographic region 2-1.For example, the application processing module 34 of the application unit 16 generates the one or more prescriptions and sends the one or more prescriptions, via the network 24, to the wireless communication network 2.The wireless communication network 2 sends wireless communication signals 42 to the user device 2-1C, where the wireless communication signals 42 includes the one or more prescriptions.", "The user device 2-1C sends further wireless communication signals 42 to the user device 2-1B, where the further wireless communication signals 42 include the one or more prescriptions.", "Having obtained the one or more prescriptions associated with the geographic region 2-1, the user device 2-1B interprets received data, via interface information 40, from the user device 2-1A to produce raw sensor data sets for the geographic region 2-1.For example, the user device 2-1B receives the interface information 40 from the user device 2-1B during traversal of the drive path 2-1 to produce the raw sensor data sets.", "Having produced the raw sensor data sets, the user device 2-1B obtains location information associated with the raw sensor data sets.", "The obtaining includes at least one of interpreting the received data and interpreting wireless location signals 38 received directly from the wireless location network 18.Having obtained the location information, the user device 2-1B associates the raw sensor data sets with the obtained location information to produce location enabled sensor data sets.", "For example, the user device 2-1B tags each sensor data value with a corresponding location coordinate, where the sensor data value pertains to the location coordinate.", "Having produced the location enabled sensor data sets, the user device 2-1B stores the location enabled sensor data sets in a local memory.", "Having stored the location enabled sensor data sets, the user device 2-1B identifies at least one prescription of the one or more prescriptions associated with the location information.", "For example, the user device 2-1B identifies location coordinates of a prescription that substantially match location information of the location enabled sensor data sets.", "For instance, the user device 2-1B identifies a prescription associated with geographic region 2-1.Having identified the at least one prescription, the user device 2-1B associates the identified prescription with the location enabled sensor data sets to produce prescription based location enabled sensor data sets.", "For example, the user device 2-1B tags the location enabled sensor data sets with an identifier of the identified prescription to produce the prescription based location enabled sensor data sets.", "Having produced the location enabled sensor data sets, the user device 2-1B performs a filtering function on the prescription based location enabled sensor data sets in accordance with a filter identifier of the identified prescription to produce sensor data sets for the geographic region 2-1.For example, the user device 2-1B discards one or more portions of sensor data not associated with the prescription while retaining other portions of the sensor data associated with the prescription.", "Having performed the filtering function, the user device 2-1B sends, via the user device 2-1C, by wireless communication network 2, and the network 24, the sensor data sets for geographic region 2-1 to the storage unit 36 for storage and subsequent processing by the application unit 16 to produce at least one of a new prescription and an updated prescription.", "For example, the application unit receives guidance 72 from the user device with regards to the geographic region 2-1 (e.g., an instruction to collect sensor data), obtains data records 2 that includes the sensor data sets for geographic region 2-1, generates the at least one of the new prescription and the updated prescription, and sends, via the network 24, the at least one of the new prescription and the updated prescription to the user device 14 and, via the wireless network 2 and the user device 2-1C, to the user device 2-1B for further execution of steps within the geographic region 2-1.The operation of the user device 2-1B is discussed in greater detail with reference to FIG.", "12B.", "FIG.", "12B is a schematic block diagram of an embodiment of a drive unit 120 that includes a first interface 124, the computing unit 26 of FIG.", "5, and a second interface 126.The drive unit 120 may be implemented utilizing the user device 2-1B of FIG.", "12A.", "The first interface 124 includes a controller area network (CAN) bus interface 110 to establish a first communication path with farm equipment (e.g., any equipment associated with execution of one or more steps of an agricultural prescription associated with an agricultural lifecycle such as the user device 2-1A of FIG.", "12A, i.e., a farming tractor).", "The first communication path may be utilized to communicate one or more of sensor data and controller data between the farm equipment and the drive unit 120, where one or more sensors associated with the farm equipment produce sensor data and one or more controllers associated with the farm equipment produces the controller data.", "The one or more sensors and the one or more controllers may conform to a very sensor types and various controller types in accordance with a farm equipment type.", "For example, when the farm equipment includes a tractor, examples of sensor types includes engine speed, fuel consumption, an area/distance counter (e.g., GPS, radar), power take off (PTO), tractor hydraulics (e.g., pressure, flow), hydraulic pump speed, wheel speed, and wheel slippage; and examples of controllers includes hydraulic directional, pressure, and flow controllers, hydraulic pump speed, speed controller, hitch position controller, and a wheel position controller.", "As another example, when the farm equipment includes seed planting equipment (e.g., a planter, a drill, an air seeder), examples of sensor types includes speed sensors (e.g., optical, other electromagnetic sensors, impacts sensors), downforce sensors (e.g., load pins, load cells, pressure sensors), soil property sensors, (e.g., reflectivity sensors, moisture sensors, electrical conductivity sensors, optical residue sensors, temperature sensors), component operating criteria sensors (e.g., planting depth sensors, and downforce cylinder pressure sensors, seed disc speed sensors, seed drive motor encoder, seed conveyor system speed sensors, vacuum level sensors), and pesticide application sensors (e.g., optical, other electromagnetic sensors, impacts sensors); and examples of controllers includes toolbar fold controller (e.g., valves associated with hydraulic cylinders), downforce controllers (e.g., valves associated with pneumatic cylinders, airbags, hydraulic cylinders) for applying downforce applied to individual row units or entire planter frame, planting depth controller (e.g., linear actuator), metering controllers (e.g., electric seed meter drive motors, hydraulic seed meter drive motors, swath control clutches), hybrid selection controllers (e.g., seed meter drive motors, actuators selectively allowing or preventing seed or air/seed mixture from delivering seed to or from seed meters or central bulk hoppers), seed conveyor system controllers (e.g., belt seed delivery conveyor motor), marker controllers (e.g., pneumatic/hydraulic actuator), and pesticide application rate controller (e.g., metering drive controller, orifice size/position controller).", "As another example, when the farm equipment includes tillage equipment (e.g., a tiller), examples of sensor types includes tool (e.g., shank, disc) position sensors (e.g., depth, gang angle, lateral spacing), downforce sensors, and draft force sensors; and examples of controller types includes downforce controllers and tool position controllers (e.g., depth, gang angle, lateral spacing).", "As another example, when the farm equipment includes fertilizing or insecticide application equipment (e.g., un-planter starter fertilizer system, subsoil fertilizer applicator, fertilizer spreader), examples of sensor types includes fluid system criteria sensors (e.g., flow, pressure) sensors associated with a tank, sectional order system-wide supply line, and row-specific supply line, kinematic sensors (e.g., accelerometers disposed on a sprayer boom); and example of controller types includes pump speed controllers, valve (e.g., pressure control, flow control, directional) controller, and position actuators (e.g., boom height, subsoil depth).", "As another example, when the farm equipment includes harvesting equipment (e.g., a harvester), examples of sensor types includes a yield monitor (e.g., impact plate strain gauge or position sensors, capacitive flow sensor, load/weight sensor or torque sensor associated with elevator or auger, optical or other electromagnetic grain height sensors), grain moisture sensors (e.g., capacitive sensors), a grain loss sensor (e.g., impact, optical, capacitive), header operating criteria sensors (e.g., header height, header type, deck plate gap, feeder speed, reel speed), separator operating criteria sensors (e.g., concave clearance, rotor speed, shoe clearance, chaffer clearance), auger position/operation/speed sensors, and an engine speed sensor; and examples of controllers includes header operating criteria controllers (e.g., header height, header type, deck plate, feeder speed, reel speed), separator operating criteria controllers (e.g., concave clearance, rotor speed, shoe clearance, chaffer clearance), and auger position/operation/speed controllers.", "As another example, when the farm equipment includes a grain cart, examples of the sensor types includes weight sensors and auger position/operation/speed sensors; and examples of controller types includes auger position/operation/speed controllers.", "Alternatively, or in addition to, the first interface 124 may be implemented utilizing an on-board diagnostics (OBD) interface or any other de facto or de jure industry standard interface.", "The computing unit 26 includes the application processing module 34 of FIG.", "5 and the memory 58 of FIG.", "5.The second interface 126 includes a Bluetooth wireless location modem 1 to establish a second communication path with a portable computing device 122 (e.g., the user device 2-1C of FIG.", "12A).", "Alternatively, or in addition to, the second interface 126 includes at least one of a Wi-Fi indication modem, a 60 GHz communication modem, an infrared communication modem, any other wireless connectivity wireless communication modem, and a wireline interface (e.g., a universal serial bus (USB) interface) may be utilized in lieu of the Bluetooth wireless communication modem 1.The user device 2-1B is operable to facilitate the collecting of the data to generate the agricultural prescription.", "In an example of operation of the facilitating of the collecting of the data to generate the agricultural prescription, the Bluetooth wireless communication modem 1 interprets Bluetooth wireless communication signals 116 from the user device 2-1C to produce wireless messages 1, where the wireless messages 1 have been encoded with one or more agricultural prescriptions.", "The application processing module 34 extracts the one or more agricultural prescriptions from the wireless messages 1 and stores the one or more agricultural prescriptions in the memory 58.Having received the one or more agricultural prescriptions, the CAN bus interface 110 receives CAN data 114 from the user device 2-1A to produce interface information 40.The application processing module 34 interprets the interface information 40 to produce raw sensor data sets.", "For example, the application processing module 34 decodes the interface information 40 in accordance with a CAN industry standard to produce the raw sensor data sets.", "Having produced the raw sensor data sets, the application processing module 34 interprets the raw sensor data sets to produce location information.", "As a specific example, the application processing module 34 extracts coordinated universal time (UTC) and global positioning system (GPS) coordinates from the CAN data 114, where the user device 2-1A receives the GPS location signals 112 to produce the UTC.", "As another specific example, the application processing module 34 synchronizes a local time with the extracted UTC to produce a synchronized local time and further processes (e.g., interpolation, geolocation refinement) the extracted GPS coordinates utilizing the synchronized local time to provide the location information.", "Having produced the location information, the application processing module 34 associates the raw sensor data sets with the obtained location information to produce location enabled sensor data sets.", "For example, the application processing module tags sensor data with corresponding UTC and GPS location coordinates of time-of-receipt to produce the location enabled sensor data sets.", "Having produced the location enabled sensor data sets, the application processing module 34 stores the location enabled sensor data sets in the memory 58.The application processing module 34 identifies at least one prescription of the one or more prescriptions associated with the location information.", "For example, the application processing module 34 identifies a geographic location area associated with the prescription that is substantially the same as the obtained location information.", "Having identified the prescription, the application processing module 34 associates the identified prescription with the location enabled sensor data sets to produce prescription based location enabled sensor data sets.", "For example, the application processing module 34 tags the location enabled sensor data sets with an identifier of the identified prescription to produce these prescription based location enabled sensor data sets.", "Having produced the prescription based location enabled sensor data sets, the application processing module 34 performs a filtering function on the prescription based location enabled sensor data sets in accordance with a filter identifier of the identified prescription to produce sensor data sets.", "For example, the application processing module 34 discards one or more portions of sensor data and not associated with the prescription.", "Alternatively, the application processing module 34 applies a null filter to prevent discarding any sensor data.", "The application processing module 34 generates further wireless messages 1 based on the sensor data sets.", "Having produced the further wireless messages 1, the application processing module 34 sends the further wireless messages 1 to the Bluetooth wireless communication modem 1 for transmission to the user device 2-1C for retransmission, via any one or more wireless industry standards, including fourth-generation (4G) wireless communication signals 118, to a storage unit for storage and subsequent processing to produce at least one of an updated agricultural prescription and a new agricultural prescription.", "In another example of operation of the facilitating of the collecting of the data by the drive unit 120 to generate the agricultural prescription, the drive unit 120 receives, via the first interface 124 of the drive unit 120, data from farm equipment to produce agricultural data.", "For example, the CAN bus interface 110 receives the CAN data 114 from the user device 2-1A (e.g., a tractor) and produces interface information for at least temporary storage in the memory 58, where the CAN data 114 and the interface information 40 includes the data.", "The agricultural data may include one or more of location information, timestamp information, terrain information, soil sampling information, accelerometer information, gyroscope information, velocity information, weather information, magnetic field information, imaging data, chemical detection, fluid flow volume, sensor data, and execution phase of an agricultural prescription.", "The producing of the agricultural data may include the drive unit 120 receiving, via the second interface 126 of the drive unit 120, additional data from the portable computing device 122.For example, the computing unit 26 receives wireless messages 1 (e.g., including the additional data) from the Bluetooth wireless communication modem 1, where the Bluetooth wireless location modem 1 interprets Bluetooth wireless communication signals 116 received from the user device 2-1C.", "Having received the additional data, the application processing module 34 integrates the additional data with the data to produce the agricultural data.", "The producing of the agricultural data may further include the drive unit 120 receiving, via the first interface 124 of the drive unit 120, first location information from the farm equipment.", "For example, the CAN bus interface 110 receives the CAN data 114 from the user device 2-1A to produce interface information 40 that includes the first location information, where the user device 2-1A interprets the GPS wireless location signals 112 (e.g., GPS wireless location signals 1) to produce the first location information (e.g., location information 1).", "Alternatively, the user device 2-1A produces the CAN data 114 to include null first location information when the GPS wireless location signals 112 are unavailable to the user device 2-1A or when the user device 2-1A is unable to interpret the GPS wireless location signals 112.Having received the first location information, the drive unit 120 receives, via the second interface 126 of the drive unit 120, second location information (e.g., location information 2) from the portable computing device 122.For example, the Bluetooth wireless communication modem 1 receives Bluetooth wireless communication signals 116 to produce the wireless messages 1 that includes the second location information, where the user device 2-1C interprets the GPS wireless location signals 112 (e.g., GPS wireless location signals 2 of proximal location to the GPS wireless location signals 1) to produce the second location information.", "Having received the wireless messages 1, the application processing module 34 processes the wireless messages 1 to produce the second location information.", "For example, the application processing module 34 extracts the second location information from the wireless messages 1.As another example, the application processing module 34 facilitates conversion of the wireless messages 1 into a format associated with the CAN data 114, where the second location information is represented in received interface information 40.As another example, the application processing module 34 interprets the wireless messages 1 as the format of the CAN data 114 utilizing the CAN bus industry standard to produce the second location information, when the portable computing device 122 encodes the second location information utilizing the CAN bus industry standard.", "Having received the first and second location information, the drive unit 120 integrates the first and second location information into composite location information (e.g., location information 388 of FIG.", "20B) as part of the agricultural data.", "The receiving of the first and second location information and producing of the composite location information is discussed in greater detail with reference to FIGS.", "20A-C. Having produced the agricultural data, the drive unit 120 determines a filtering constraint based on one or more parameters selected from a plurality of lists of agricultural parameters.", "The plurality of lists of agricultural parameters includes two or more of a list of crop cycle parameters, a list of types of agricultural prescription parameters, and a list of types of farm equipment.", "The list of crop cycle parameters includes one or more of a planting cycle, a harvesting cycle, a tending cycle, a fertilizing cycle, a watering cycle, and a weeding cycle.", "The list of types of agricultural prescription parameters includes one or more of a planting plan, a tillage plan, a crop transportation plan, a speed plan, a fertilizing plan, a watering plan, a weeding plan, and a harvesting plan (e.g., each plan may include a geographic location, a pattern of traversal of the geographic location, a distribution pattern, a volume of distribution specification, and a schedule).", "The list of types of farm equipment includes one or more of planting equipment, a tractor, fertilizing equipment, watering equipment, weeding equipment, and harvesting equipment, etc.", "The selecting the one or more parameters may include the drive unit 120 receiving, via the second interface 126 of the drive unit 120, an instruction to collect a particular type of data.", "For example, the computing unit 26 receives a wireless message 1 that includes the instruction to collect the particular data from the Bluetooth wireless location modem 1, where the Bluetooth wireless communication modem 1 receives Bluetooth wireless communication signals 116 that includes the instruction from the user device 2-1C, and where the user device 2-1C receives 4G wireless communication signals 118 that includes the instruction.", "Having received the instruction, the drive unit 120 selects the one or more parameters based on the instruction.", "For example, the application processing module 34 includes the planting cycle, the planting plan, and the planting equipment parameters in the filtering constraint when the received instruction includes a gather planting information instruction.", "Having determined the filtering constraint, the drive unit 120 filters the agricultural data based on the filtering constraint to produce filtered agricultural data.", "For example, the application processing module 34 retrieves the agricultural data from the memory 58 and filters the agricultural data using the planting parameters to produce the filtered agricultural data with regards to the planting information.", "Having produced the filtered agricultural data, the drive unit 120 determines processing of the filtered agricultural data.", "The processing of the filtered agricultural data includes processing of the filtered agricultural data by the drive unit 120 and/or processing of the filtered agricultural data by a host server (e.g., the application unit 16).", "The determining may be based on one or more of a received instruction, a value of a portion of the filtered agricultural data (e.g., a comparison of the value to a value threshold is favorable to trigger the processing determining), an ability level of the user device 2-1A to execute a modified agricultural prescription versus an existing agricultural prescription, and a level of a number of further farm equipment required to execute the existing agricultural prescription.", "For example, the drive unit 120 determines to process the filtered agricultural data locally (e.g., by the drive unit 120) when a change to the existing agricultural prescription is feasible.", "As another example, the drive unit 120 determines to have the filtered agricultural data processed by the host server (e.g., the application unit 16 of FIG.", "12A) when the existing agricultural prescription includes an indicator for the host server to modify existing agricultural prescriptions.", "Having determined the processing of the filtered agricultural data, the drive unit 120 facilitates the executing of the processing of the filtered agricultural data.", "As an example of determining the processing of the filtered agricultural data and the executing the processing of the filtered agricultural data, the application processing module 34 determines that the filtered agricultural data is to be processed by the drive unit 120 for modifying the existing agricultural prescription, modifies the existing agricultural prescription in accordance with the filtered agricultural data to produce the modified agricultural prescription, and outputs, via the first interface 124 of the drive unit 120, the modified agricultural prescription to the farm equipment (e.g., sends the modified agricultural prescription and/or steps associated with the modified agricultural prescription to the user device 2-1A encoded as CAN data 114).", "As another example of the determining the processing of the filtered agricultural data and the executing the processing of the filtered agricultural data, the application processing module 34 determines that the filtered agricultural data is to be processed by the host server, and outputs, via the second interface 126 of the drive unit 120, the filtered agricultural data to the host server (e.g., generates wireless messages 1 to include the filtered agricultural data, the Bluetooth wireless communication modem 1 sends Bluetooth wireless communication signals 116 that includes the filtered agricultural data to the user device 2-1C, the user device 2-1C sends 4G wireless communication signals 118 that includes the filtered agricultural data to the host server).", "Having sent the filtered agricultural prescription, the drive unit 120 receives, via the second interface 126 of the drive unit 120, a new agricultural prescription or a modified agricultural prescription from the host server (e.g., the application processing module 34 receives further wireless messages 1 that includes the modified agricultural prescription), and outputs, via the first interface 124 of the drive unit 120, the new agricultural prescription or the modified agricultural prescription to the farm equipment (e.g., using the interface information 40 to the CAN bus interface 110 and encoded as CAN data 114 to the user device 2-1A).", "FIG.", "12C is a flowchart illustrating an example of collecting data to generate an agricultural prescription.", "The method begins or continues at step 140 where a processing module (e.g., of a user device) obtains one or more agricultural prescriptions.", "The obtaining includes at least one of initiating a query, receiving a query response, and autonomously receiving the one or more agricultural prescriptions.", "The method continues at step 142 where the processing module interprets received data to produce raw sensor data sets of a current geographic region.", "For example, the processing module converts received data into information using an associated protocol standard.", "The method continues at step 144 where the processing module obtains location information of the current geographic region.", "As a specific example, the processing module interprets the received data to extract UTC and location coordinates.", "As another specific example, the processing module interprets received wireless location signals to produce the UTC and location coordinates.", "The method continues at step 146 where the processing module associates the raw sensor data sets with the obtained location information to produce location enabled sensor data sets.", "As a specific example, the processing module attaches time tags of time arrival and location coordinates to portions of the raw sensor data set to produce the location enabled sensor data sets.", "The method continues at step 148 where the processing module stores the location enabled sensor data sets available memory.", "The method continues at step 150 where the processing module identifies at least one agricultural prescription associated with the location information.", "As a specific example, the processing module identifies a region of the prescription that substantially matches a region of the location information.", "The method continues at step 152 where the processing module associates the identified agricultural prescription with the location enabled sensor data sets to produce prescription based location enabled sensor data sets.", "As a specific example, the processing module tags the location enabled sensor data sets with an identifier of the identified agricultural prescription.", "The method continues at step 154 where the processing module performs a filtering function on the prescription based location enabled sensor data sets in accordance with a filter identifier of the identified agricultural prescription to produce sensory data sets for the current geographic location.", "As a specific example, the processing module identifies portions of the data associated with the agricultural prescription and discards remaining portions.", "The method continues at step 156 where the processing module sends the sensor data sets to a storage unit for storage and subsequent processing of the sensor data sets to produce at least one of an updated prescription and a new prescription.", "As a specific example, the processing module sends the sensor data sets via a wireless link to another user device for retransmission, via a wireless network, to the storage unit.", "As another specific example, the processing module sends, via a wireline connection, the sensor data sets to yet another user device for retransmission to the storage unit.", "FIG.", "12D is a flowchart illustrating another example of collecting data to generate an agricultural prescription.", "In particular, a method is presented for use in conjunction with one or more functions and features described in conjunction with FIGS.", "1-11, 12A-C, and also FIG.", "12D.", "The method begins at step 160 where a processing module of one or more processing modules of a drive unit and/or of one or more computing devices affiliated with farm equipment receives (e.g., via a first interface of the drive unit) data from the farm equipment to produce agricultural data.", "The producing of the agricultural data may include the processing module receiving (e.g., via a second interface of the drive unit) additional data from a portable computing device (e.g., a smart phone carried by a farm equipment operator, a laptop) and integrating the additional data with the data to produce the agricultural data.", "The producing of the agricultural data may further include the processing module receiving (e.g., via the first interface of the drive unit) first location information from the farm equipment, receiving (e.g., via the second interface of the drive unit) second location information from the portable computing device, and integrating the first and second location information into composite location information.", "The method continues at step 162 where the processing module determines a filtering constraint based on one or more parameters selected from a plurality of lists of agricultural parameters.", "The selecting the one or more parameters may include the processing module receiving (e.g., via a second interface of the drive unit) an instruction to collect a particular type of data and selecting the one or more parameters based on the instruction.", "The method continues at step 164 where the processing module filters the agricultural data based on the filtering constraint to produce filtered agricultural data.", "The method continues at step 166 where the processing module determines processing of the filtered agricultural data.", "As an example of the determining the processing of the filtered agricultural data, the processing module determines that the filtered agricultural data is to be processed by the drive unit for modifying an existing agricultural prescription.", "As another example of the determining the processing of the filtered agricultural data, the processing module determines that the filtered agricultural data is to be processed by a host server.", "The method branches to step 172 when the processing module determines that the filtered agricultural data is to be processed by the host server.", "The method continues to step 168 when the processing module determines that the filtered agricultural data is to be processed by the drive unit.", "When determining that the filtered agricultural data is to be processed by the drive unit for modifying the existing agricultural prescription, the method continues at step 168 where the processing module initiates execution of the processing of the filtered agricultural data by modifying the existing agricultural prescription in accordance with the filtered agricultural data to produce a modified agricultural prescription.", "The method continues at step 170 where the processing module outputs (e.g., via the first interface of the drive unit) the modified agricultural prescription to the farm equipment.", "When determining that the filtered agricultural data is to be processed by a host server, the method continues at step 172 where the processing module initiates the execution of the processing of the filtered agricultural data by outputting (e.g., via the second interface of the drive unit) the filtered agricultural data to the computing device (e.g., for processing by one or more of the computing device as the host server and another remote computing device as the host server).", "The method continues at step 174 where the processing module receives (e.g., via the second interface of the drive unit) a new agricultural prescription or a modified agricultural prescription.", "The method continues at step 176 where the processing module outputs (e.g., via the first interface of the drive unit) the new agricultural prescription or the modified agricultural prescription to the farm equipment.", "The method described above in conjunction with the processing module can alternatively be performed by other modules of the one or more computing devices affiliated with the farm equipment or by other devices associated with general agricultural equipment.", "In addition, at least one memory section (e.g., a non-transitory computer readable storage medium) that stores operational instructions can, when executed by one or more processing modules of the one or more computing devices affiliated with the farm equipment, cause the one or more computing devices to perform any or all of the method steps described above.", "FIG.", "13A is a schematic block diagram of another embodiment of a computing system that includes the geographic region 1 of FIG.", "1, the wireless communication network 1 of FIG.", "1, the network 24 of FIG.", "1, the user device 14 of FIG.", "5, the application unit 16 of FIG.", "5, and the storage unit 36 of FIG.", "5.The user device 14, the application unit 16, and the storage unit 36 include the application processing module 34 of FIG.", "5.Hereafter, the application unit 16 may be interchangeably referred to as a computing device.", "The storage unit 36 further includes the memory 58 of FIG.", "5.The geographic region 1 covers a farming geographic area and includes a fleet of farming equipment (e.g., agricultural equipment).", "The fleet of farming equipment includes at least associated user devices 1-1A, 1-2A, 1-1C, and 1-2C of FIG.", "1, and actuators 1A and 2A, where actuator set 1A is associated with user devices 1-1A, and actuator set 2A is associated with user device 1-2A.", "The geographic region 1 may include further associations of user devices and actuators.", "The user device 1-1A traverses portions of drive paths 1, 2, and 3 with a velocity of A within the geographic region 1 in accordance with an agricultural prescription 1A and the user device 1-2A traverses portions of drive paths 2 and 3 with a velocity of B within the geographic region 1 in accordance with an agricultural prescription 2A.", "The agricultural prescriptions 1A and 2A are discussed in greater detail with reference to FIG.", "13B.", "The computing system is operable to update resource assignments associated with an agricultural prescription (e.g., modifying assignment of steps of the agricultural prescriptions to the user devices).", "In an example of operation of the updating of the resource assignments, the application unit 16 generates the agricultural prescriptions 1A and 2A based on data records 1 and guidance 72 from the user device 14, where the agricultural prescriptions includes action data that includes a plurality of steps to be executed by at least one of user devices 1-1A and 1-2A.", "The data records 1 include historical sensor data sets for region 1, received from resources associated with geographic region 1.Having generated the prescriptions, the application unit 16 determines an availability level of resources (e.g., tractor availability, combine availability, fertilizer applicator availability, and task execution capacity level for resources) for assignment of portions of the agricultural prescriptions.", "The determining may be based on one or more of initiating a query, interpreting the received query response, performing a lookup, interpreting a schedule, and estimating.", "Having determined the availability level, the application unit 16 selects one or more resources based on the availability levels (e.g., prioritizes selection of resources associated with the most favorable availability levels).", "For each selected resource, the application unit 16 assigned to a portion of the agricultural prescription, where each portion of the agricultural prescription includes a schedule for at least some of the plurality of steps and schedule time frames for at least some of the steps.", "For example, the application unit partitions the plurality of steps between the resources based on the availability levels and sends the assigned portions of the steps to the resources.", "For instance, the application unit sends the prescriptions 1A and 2A, via the network 24 and the wireless communication network 1, to the user devices 1-1A and 1-2A.", "While the resources are executing the agricultural prescription, the application unit 16 monitors subsequently generated data records from the assigned resources.", "For example, the application unit receives data records 1 that includes subsequent sensor data sets for region 1.For instance, user device 1-1A sends sensor data sets as steps are executed along one or more of the drive paths 1-3.When a time difference between actual execution of a subset of steps and scheduled execution of the subset of steps exceeds a time threshold (e.g., detection of the unfavorable schedule adherence), the application unit 16 updates the availability level of the resources.", "For example, the application unit 16 detects unfavorable schedule adherence (e.g., too far behind schedule, too far ahead of schedule, unnecessarily idling) by the user device 1-1A while executing the steps of the prescription 1-A.", "The application unit 16 may issue an analysis summary 78 that includes a schedule adherence alert, via the network 24, to the user device 14 (e.g., associated with a farm foreman).", "Having updated the availability level of the resources, the application unit 16 re-assigns un-executed portions (e.g., unexecuted steps) of the agricultural prescription to produce updated prescriptions based on the updated availability level of the resources.", "For example, the application unit 16 re-partitions remaining steps based on the updated availability levels and sends the re-assigned remaining steps to the assigned resources.", "For instance, the application unit 16 moves steps associated with drive paths 2 and 3 from assignment with user device 1-1A over to user device 1-2A.", "Having produced the updated prescriptions, the application unit 16 sends the updated prescriptions to the user devices 1-1A and 1-2A for subsequent execution.", "In another example of operation of the updating of the resource assignments associated with the agricultural prescription the computing device (e.g., application unit 16) allocates a plurality of tasks of the agricultural prescription for the farming geographic area to the fleet of farming equipment.", "The agricultural prescription includes one or more of a planting plan, a tillage plan, a crop transportation plan, a speed plan, a fertilizing plan, a watering plan, a weeding plan, and a harvesting plan.", "The allocating the plurality of tasks includes the computing device obtaining capabilities of each piece of farm equipment of the fleet of farming equipment and affiliating a task of the plurality of tasks with a piece of farm equipment based on the capabilities of the piece of farm equipment.", "The obtaining capabilities of a piece of farm equipment may include a variety of approaches.", "A first approach to obtain the capabilities of the farm equipment includes determining an estimated task efficiency (e.g., acres per hour) with which the equipment can perform the task.", "The estimated task efficiency may be based on a width or number of row units of the implement and/or a maximum recommended speed of operation of the implement.", "For example, a planter equipped with a seed-to-ground conveying system may be associated with a greater recommended speed of operation (e.g., 10 miles per hour) and thus a greater estimated task efficiency than a planter equipped only with seed tubes.", "Affiliating the task with a piece of farm equipment based on the estimated task efficiency may include determining an available amount of time (e.g., based on weather or a previously established schedule) and affiliating the task to a piece of farm equipment (e.g., an implement) having an estimated task efficiency sufficient to complete the task within the available amount of time.", "A second approach to obtain the capabilities of the farm equipment includes identifying a spatially varying criterion of a prescription (e.g., planting population, seed type, down force, depth) for one or more fields and determining whether each piece of farm equipment can effectively execute tasks affiliated with a crop input prescription.", "For example, a spatially varying criterion may be identified where a prescription for a single field requires planting a first seed type in a first sub-region of the field and a planting a second seed type in a second sub-region of the field (i.e., a “multi-hybrid planting prescription”).", "Affiliating a task with a piece of farm equipment based on a spatially varying criterion of a prescription may comprise identifying a piece of farm equipment that is capable of varying that criterion (e.g., on-the-go) during the task according to the prescription.", "For example, upon identifying a multi-hybrid planting prescription associated with a field, a planting task associated with that field may be affiliated with a planting implement having the capability to change seed types during the planting operation.", "As a further example of the allocating of the tasks, the application unit 16 allocates a first step to the user device 1-1A when the first step is most efficiently executed by the user device 1-1A and allocates a second step to the user device 1-2A when the second step is most efficiently executed by the user device 1-2A.", "While executing tasks of the plurality of tasks, at least some of the fleet of farming equipment collects task execution data (e.g., sensor data sets for region 1).", "In some embodiments, task execution data may include data gathered during execution of a task.", "The gathered data may be gathered as the sole purpose of the task, a primary purpose of the task, or a non-primary purpose of the task.", "The task execution data may be gathered during (or in some embodiments, before or after) the task and may be gathered by sensors mounted to the farming equipment and/or implement carrying out the task.", "The task execution data gathered by sensors mounted to the farming equipment is preferably associated with locations reported by a global positioning system in order to enable mapping of the gathered data.", "The task execution data includes at least one of adherence information regarding performance of an allocated task of the plurality of tasks (e.g., a piece of farming equipment determines whether it is ahead or behind a schedule of execution of one or more tasks), farm equipment sensor data (e.g., combine waste data, applicator data, planter data), farm equipment location information (e.g., GPS sensor data, Gyro sensor data, etc.", "), farm equipment operational data (e.g., data received from a tractor engine controller).", "The adherence information regarding performance of the allocated task of the plurality of tasks may include task performance data (e.g., planting performance such as planting population, hybrid type, seed meter performance, applied row unit down force or implement ride roughness; harvest performance such as yield per acre, grain moisture, grain loss or harvested area per unit of time).", "The task execution data may further include environmental data gathered (e.g., during the task) such as soil data (e.g., soil moisture, soil electrical conductivity, soil temperature, soil organic matter content, soil components, soil density, soil reflectivity) and/or atmospheric data (ambient temperature, ambient dew point, ambient humidity, precipitation, sunlight).", "As an example of the farming equipment collecting the task execution data, the user device 1-2A collects combine waste data as the sensor data sets for region 1 and sends the sensor data sets for region 1, using the user device 1-2C, via the wireless communication network 1 and the network 24, to the application unit 16.As another example, the user device 1-1A collects timestamps associated with execution of steps of the agricultural prescription 1A, compares the timestamps to scheduled timestamps of the steps, indicates unfavorable schedule adherence when a timestamp compares unfavorably to a schedule timestamp, and sends unfavorable schedule adherence information as the sensor data sets for region 1 to the application unit 16.Based on the task execution data, the computing device updates at least one of the agricultural prescription, the plurality of tasks, and the allocation of at least one task of the plurality of tasks.", "The updating includes a plurality of updating approaches.", "In a first updating approach, the application unit 16 interprets the task execution data in accordance with expected performance of the agricultural prescription to produce an actual performance level and when the actual performance level is unfavorable, the application unit 16 determines whether to update the agricultural prescription, the plurality of tasks, or the allocation of at least one task of the plurality of tasks.", "The determining may include selecting one or more of the updating of the agriculture prescription, the updating of the plurality of task, and the allocation of the at least one task of the plurality of tasks.", "The selecting may be based on one or more of a predetermination, an estimated crop yield, resource availability, geographic sub-region availability (e.g., based on weather conditions, etc.", "), and updated resource capability levels.", "For example, the application unit 16 selects a second piece of farm equipment to execute a task originally assigned to a first piece of farm equipment when the first piece of farm equipment is unavailable or has fallen behind schedule of execution of previously assigned tasks.", "As another example, the application unit 16 adds an additional fertilizing step as another task to compensate for changing soil conditions as indicated by the task execution data.", "In a second updating approach, the application unit 16 gathers weather information, determines that weather is either adversely affecting execution of one or more tasks of the plurality of tasks (e.g., actual adverse effect) or may adversely affect future execution of the one or more tasks of the plurality of tasks (e.g., pending adverse effect).", "Having determined the actual or pending adverse effect, to minimize the adverse effects of the weather, the application unit 16 updates the at least one of the agricultural prescription (e.g., one or more prescriptions), the plurality of tasks, and the allocation of at least one task of the plurality of tasks.", "The updating to minimize the adverse effects of the weather is discussed in greater detail with reference to FIGS.", "19A-B.", "The determining that the weather is adversely affecting or may adversely affect execution of one or more tasks may include determining and/or estimating a workability index (e.g., a field-specific, task-specific, and/or implement-specific workability index).", "Field workability conditions may indicate a degree to which a field or section of a field may be worked for a given time of year using one or more pieces of farm equipment.", "Field historical precipitation data, field predicted precipitation, and field temperatures may be retrieved over a predetermined period of time and used to determine a workability index.", "For example, the workability index may be used to derive three values of workability for particular fields, tasks or implements.", "A first value of workability includes a value of “good” workability indicating a high likelihood that field conditions are acceptable for use of the equipment during an upcoming time interval.", "A second value of workability includes a value of “Check” workability indicating that field conditions may not be ideal for the use of the equipment during an upcoming time interval.", "A third value of workability includes a value of “stop” workability indicating that field conditions are not suitable for work during an upcoming time interval.", "Determined values of workability may vary depending upon the task.", "For example, planting and tilling typically require a low level of muddiness and may require a higher workability index to achieve a value of “good” than activities that allow for a higher level of muddiness.", "In some embodiments, workability indices are distinctly calculated for each activity based on a distinct set of factors.", "For example, a workability index for planting may correlate to predicted temperature over the next 60 hours while a workability index for harvesting may be correlated to precipitation alone.", "In a third updating approach, the application unit 16 interprets the task execution data to detect one or more of: unfavorable combine waste (e.g., not harvesting an optimal level of corn), unfavorable planting errors (e.g., not planning on of seeds in a particular geographic sub-region), and unfavorable application data (e.g., dispensing of an applicant such as liquid fertilizer).", "When the one or more of: unfavorable combine waste, unfavorable planting errors, and unfavorable application data is detected, the application unit 16 determines whether to update the agricultural prescription, the plurality of tasks, or the allocation of at least one task of the plurality of tasks.", "The updating when the unfavorable combine waste is detected is discussed in greater detail with reference to FIGS.", "14A-B.", "The updating when the unfavorable planting errors are detected is discussed in greater detail with reference to FIGS.", "15A-B.", "The updating when the unfavorable application data is detected is discussed in greater detail with reference to FIGS.", "16A-B.", "When updating the plurality of tasks, the application unit 16 updates the plurality of tasks by one or more of adding a new task to the plurality of tasks, deleting an existing task of the plurality of tasks and modifying a task of the plurality of tasks.", "When updating the agricultural prescription, the application unit 16 updates the agricultural prescription by one or more of changing execution scheduling of one or more tasks of the plurality of tasks; adding, deleting, or modifying one or more planting steps; adding, deleting, or modifying one or more speed steps; adding, deleting, or modifying one or more fertilizing steps; adding, deleting, or modifying one or more watering steps; adding, deleting, or modifying one or more weeding steps; and adding, deleting, or modifying one or more harvesting steps.", "When updating the allocation of the at least one task of the plurality of tasks, the application unit 16 updates the allocation of the at least one task of the plurality of tasks by one or more of reallocating an unexecuted task of the plurality of tasks from one piece of farming equipment to another piece of farming equipment of the fleet of farming equipment, reallocating a partially completed task of the plurality of tasks from the one piece of farming equipment to the other piece of farming equipment of the fleet of farming equipment, and allocating a new task to one of the fleet of farming equipment.", "The updating of the allocation of the at least one task of the plurality of tasks is discussed in greater detail with reference to FIGS.", "13B-C. FIGS.", "13B-C are a diagram of agricultural prescription resource mapping where the prescriptions 1A and 2A include initially assigned action data for user devices 1-1A and 1-2A in accordance with the agricultural prescription.", "For example, the user device 1-1A is assigned to perform action data 1,1, 1,2, 1,3 along drive path 1, action data 2,1 and 2,2 along drive path 2, and action data 3,4 along drive path 3 while user device 1-2A is assigned to perform further action data 2,3, 2,4, and 2,5 along the drive path 2 and further action data 3,1, 3,2, and 3,3 along the drive path 3.FIG.", "13B illustrates an example of operation, the user device 1-1A falls behind schedule while executing the assigned tasks along the drive paths 1-3 and reports sensor data to the application unit of FIG.", "13A, where the sensor data includes task execution indications.", "The user device 1-2A performs tasks of prescription 2A in accordance with scheduled time frames and reports sensor data to the application unit.", "FIG.", "13C illustrates the reallocation of scheduled tasks based on updated resource availability.", "For example, the prescription 1A is modified to discard the action data steps associated with drive paths 2 and 3 while the prescription 2A is modified to add the action steps discarded from the prescription 1A such that the user device 1-2A is assigned to execution of the action steps for drive paths 2 and 3.FIG.", "13D is a flowchart illustrating an example of updating resource assignments.", "The method begins or continues at step 180 where a processing module (e.g., of an application unit) generates an agricultural prescription based on obtained data records and guidance.", "For example, the application unit obtains the data records from a storage unit, where the data records include sensor data associated with a geographic region.", "The application unit analyzes the data records in accordance with received guidance to produce an analysis.", "The application unit summarizes the analysis based on a historical summary for the geographic region.", "The application unit generates the prescription based on the analysis summary, the guidance, and the historical summary, where the prescription includes a plurality of steps and a schedule of time frames associated with the steps.", "The application unit stores the agricultural prescription.", "The method continues at step 182 where the processing module determines a level of availability of resources for assignment of portions of the agricultural prescription.", "For example, the processing module identifies resources associated with the geographic region, and, for each identified resource, the processing module determines a task execution capacity level as the level of availability for the resource, where the task execution capacity level is associated with a task type of the agricultural prescription.", "For each resource, the method continues at step 184 where the processing module assigns a portion of the agricultural prescription where each portion includes an execution schedule for steps associated with the portion.", "For example, the processing module identifies the portion of the agricultural prescription that includes a group of associated steps (e.g., of a common sub-geographic region, for a common task type), determines goals for execution of steps of the agricultural prescription (e.g., to adhere to a schedule, to be achieved under a maximum cost level, to be achieved utilizing the available materials, and to be achieved utilizing the available resources), allocates the portion to one or more of the resources based on the associated level of availability of the resources that optimizes the achievement of the desired goals, issues the assigned portions of the agricultural prescription to the resource (e.g., sends a schedule of steps to a tractor), and stores the assignments.", "While the resources are executing the agricultural prescription, the method continues at step 186 where the processing module monitors subsequent data records generated by the resources.", "For example, the processing module receives sensor data sets directly from the resources.", "As another example, the processing module recovers stored data records from the storage unit that includes recent sensor data sets associated with the executing of the agricultural prescription.", "The method continues at step 187 where the processing module detects an unfavorable schedule adherence based on the subsequent data records.", "For example, the processing module interprets the subsequent data records to identify actual execution of steps, compares the actual execution to the execution schedule for the steps associated with the agricultural prescription to produce a difference, and indicates unfavorable schedule adherence when the difference is greater than a difference threshold level (e.g., behind schedule, ahead of schedule).", "As another example, the processing module detects an unfavorable goal adherence for goals unrelated to the time schedule (e.g., too costly, too many raw materials being utilized, etc.).", "The method continues at step 188 where the processing module determines an updated level of availability of the resources.", "For example, for each identified resource, the processing module re-determines the task execution capacity level as the level of availability for the resource.", "For instance, a resource may be idling even though it has many unexecuted pending tasks.", "As another instance, another resource may have completed all tasks.", "The method continues at step 189 where the processing module re-assigns one or more unexecuted portions of the agricultural prescription based on the updated level of availability of the resources.", "For example, the processing module identifies the unexecuted portion of the agricultural prescription associated with the unfavorable schedule adherence, determines goals for execution of the steps of the agricultural prescription, re-allocates the portion to one or more of the resources based on the associated level of availability of the resources that optimizes the achievement of the desired goals, issues re-assigned portions of the agricultural prescription to the resources (e.g., send an up to date schedule of steps to another tractor), and stores the updated assignments.", "FIGS.", "13E-F are flowcharts illustrating an example of updating execution of tasks of an agricultural prescription.", "In particular, a method is presented for use in conjunction with one or more functions and features described in conjunction with FIGS.", "1-12D, 13A-D, and also FIGS.", "13E-F.", "The method begins or continues with FIG.", "13E at step 191 where a processing module of one or more processing modules of one or more computing devices affiliated with agriculture equipment (e.g., a fleet of farming equipment) allocates a plurality of tasks of an agricultural prescription for a farming geographic area to a fleet of farming equipment.", "The allocating of the plurality of tasks includes the processing module obtaining capabilities of each piece of farm equipment of the fleet of farming equipment and affiliating a task of the plurality of tasks with a piece of farm equipment based on the capabilities of the piece of farm equipment.", "While executing tasks of the plurality of tasks, the method continues at step 193 where at least some of the fleet of farming equipment collects task execution data.", "For example, a combine collects combine waste data as the task execution data and sends the task execution data to the processing module.", "Based on the task execution data, the method continues at step 195 where the processing module updates at least one of the agricultural prescription, the plurality of tasks, and the allocation of at least one task of the plurality of tasks.", "The updating is discussed in greater detail with reference to FIG.", "13F.", "FIG.", "13F is a flowchart that further illustrates the updating of the execution of the tasks of the agricultural prescription.", "In particular, FIG.", "13F further illustrates the updating of the at least one of the agricultural prescription, the plurality of task, and the allocation of the at least one task of the plurality of tasks of step 195 of FIG.", "13E.", "The method begins or continues at step 197 where the processing module of the one or more processing modules of the one or more computing devices affiliated with the agriculture equipment (e.g., the fleet of farming equipment) interprets the task execution data in accordance with expected performance of the agricultural prescription to produce an actual performance level.", "For example, the processing module compares the actual performance level to a scheduled performance level to identify an unfavorable schedule adherence.", "When the actual performance level is unfavorable, the method continues at step 199 where the processing module determines whether to update the agricultural prescription, the plurality of tasks, or the allocation of at least one task of the plurality of tasks.", "The method continues to one or more of steps to 211-215 in accordance with the determining.", "Alternatively, the method begins or continues at step 201 where the processing module gathers weather information.", "For example, the processing module receives weather data from a weather forecast unit (e.g., weather forecast unit 358 of FIG.", "19A).", "The method continues at step 203 where the processing module determines that weather is adversely affecting (e.g., or may soon adversely affect) execution of one or more tasks of the plurality of tasks.", "For example, the processing module determines that heavy rain is headed towards a first sub-region of the geographic region, where the heavy rain may adversely affect the execution of steps associated with the first sub-region.", "To minimize the adverse effects of the weather, the method continues at step 205 where the processing module updates the at least one of the agricultural prescription, the plurality of tasks, and the allocation of at least one task of the plurality of tasks.", "For example, the processing module determines to redeploy a resource associated with the first sub-region to another sub-region to execute steps associated with the other sub-region where adverse weather is not expected.", "The updating to minimize the adverse effects of the weather is discussed in greater detail with reference to FIGS.", "19A-B.", "The method continues to one or more of steps to 211-215 in accordance with the determining.", "Alternatively, the method begins or continues at step 207 where the processing module interprets the task execution data to detect one or more of: unfavorable combine waste, unfavorable planting errors, and unfavorable application data.", "When the one or more of: unfavorable combine waste, unfavorable planting errors, and unfavorable application data is detected, the method continues at step 209 where the processing module determines whether to update the agricultural prescription, the plurality of tasks, or the allocation of at least one task of the plurality of tasks.", "For example, the processing module determines to update a task of the plurality of tasks associated with establishing combine settings when the interpreting of the task execution data identifies unfavorable combine waste.", "The updating when the unfavorable combine waste is detected is discussed in greater detail with reference to FIGS.", "14A-B.", "The updating when the unfavorable planting errors are detected is discussed in greater detail with reference to FIGS.", "15A-B.", "The updating when the unfavorable application data is detected is discussed in greater detail with reference to FIGS.", "16A-B.", "When updating the plurality of tasks, the method continues at step 211 where the processing module updates the plurality of tasks by one or more of adding a new task to the plurality of tasks, deleting an existing task of the plurality of tasks, and modifying a task of the plurality of tasks.", "When updating the agricultural prescription, the method continues at step 213 where the processing module updates the agricultural prescription by one or more of changing execution scheduling of one or more tasks of the plurality of tasks; adding, deleting, or modifying one or more planting steps; adding, deleting, or modifying one or more speed steps; adding, deleting, or modifying one or more fertilizing steps; adding, deleting, or modifying one or more watering steps; adding, deleting, or modifying one or more weeding steps; and adding, deleting, or modifying one or more harvesting steps.", "When updating the allocation of at least one task of the plurality of tasks, the method continues at step 215 where the processing module updates the allocation of the at least one task of the plurality of tasks by one or more of reallocating an unexecuted task of the plurality of tasks from one piece of farming equipment to another piece of farming equipment of the fleet of farming equipment, reallocating a partially completed task of the plurality of tasks from the one piece of farming equipment to the other piece of farming equipment of the fleet of farming equipment, and allocating a new task to one of the fleet of farming equipment.", "The method described above in conjunction with the processing module can alternatively be performed by other modules of the one or more computing devices affiliated with the fleet of farming equipment or by other devices associated with general agricultural equipment.", "In addition, at least one memory section (e.g., a non-transitory computer readable storage medium) that stores operational instructions can, when executed by one or more processing modules of the one or more computing devices affiliated with the farming equipment, cause the one or more computing devices to perform any or all of the method steps described above.", "FIG.", "14A is a schematic block diagram of another embodiment of a computing system that includes the geographic region 1 of FIG.", "1, the wireless communication network 1 of FIG.", "1, the network 24 of FIG.", "1, the user 14 device of FIG.", "5, the application unit 16 of FIG.", "5, and the storage unit 36 of FIG.", "5.The geographic region 1 includes associated user devices 1-1A, and 1-1C of FIG.", "1, with a combine actuator set 1A.", "The geographic region 1 may further include a user device 1-1B to provide communication and processing of information between the user device 1-1C and the user device 1-1A in a similar fashion as user device 2-1B provides processing and communication between user devices 2-1C and 2-1A of FIG.", "12A.", "The user device 1-1A includes sensors 190, the application processing module 34 of FIG.", "4, and the wireless communication modem 1 of FIG.", "4.The sensors 190 include at least some of the sensors 1-7 of FIG.", "7.The user device 1-1A traverses portions of a drive path 1 within the geographic region 1 in accordance with an agricultural prescription 1.The computing system is operable to identify an unfavorable crop harvesting output level.", "In an example of operation of the identifying of the unfavorable crop harvesting output level, the user device 1-1A facilitates execution of the prescription 1 with regards to combining a crop for harvesting.", "For example, the user device 1-1A receives the prescription 1 from the wireless communication modem 1, where the application unit 16 sends, via the network 24, the prescription 1 to the wireless communication network 1, where the wireless communication network 1 sends wireless communication signals 42, that includes the prescription 1, to the user device 1-1C, and where the user device 1-1C issues further wireless communication signals 42, that includes the prescription 1, to the wireless communication modem 1.Having received the prescription 1, the application processing module 34 of the user device 1-1A issues control information 196 to the combine actuator set 1A based on the prescription 1.The control information 196 may include one or more settings for the combine.", "The settings include one or more of chaffer position, sieve position, concave spacing, and thresher revolutions per minute (RPM).", "The combine actuator set 1A may further operate in accordance with local settings 194 provided by an operator of the combine.", "As such, the combine operates in accordance with one or more of the local settings 194 and the control information 196.Having issued the control information 196 to the combine actuator set 1A, the application processing module 34 interprets sensor data 192 from the sensors 190 and combine status 198 to generate output data 200 and waste data 202 collectively as task execution data.", "The output data 200 includes a rate of crops produced (e.g., by count, by volume, by weight).", "The waste data 202 includes a rate of crops wasted.", "The application processing module 34 sends one or more of the sensor data 192, the output data 200, and the waste data 202 as data sets for region 1 to the storage unit 36 for storage in the memory 58 and subsequent delivery as data records 1 to the application unit 16 for further processing.", "When the output data 200 compares unfavorably to expected output data of the prescription 1 and/or when the waste data 202 compares unfavorably to expected waste data of the prescription 1, the application processing module 34 of the user device 1-1A facilitates corrective action.", "The facilitating includes selecting the action and executing the selected action.", "The selecting may be based on one or more of a predetermination, instructions extracted from the prescription 1, guidance 72 from the user device 14, and a magnitude level of the unfavorable comparison.", "The actions includes identifying a settings template 204 based on the local settings 194, issuing a settings alert 206 to one or more of the user device 14 and the storage unit 36, and executing another prescription (e.g., prescription 2) received from the application unit 16 and/or determined by the user device 1-1A based on the prescription 1.For example, the prescription 2 may include corrective action to override the local settings 194 with new control information 196 to optimize the output data 200 and waste data 202.FIG.", "14B is a flowchart illustrating an example of identifying an unfavorable crop harvesting output level.", "The method begins or continues at step 210 where a processing module (e.g., of an agricultural resource user device) facilitates execution of an agricultural prescription within a local resource that includes a combine to harvest crops.", "For example, the processing module issues control information to a combine actuator based on the agricultural prescription.", "While executing the agricultural prescription, the method continues at step 212 where the processing module interprets sensor data and combine status to generate output data and waste data associated with harvesting crops.", "The interpreting includes determining a level of crop output as the output data based on the combine status in the sensor data and determining a level of crop waste as the waste data based on the combine status in the sensor data.", "The method continues at step 214 where the processing module detects an unfavorable comparison of the output data and the waste data with expected output data and expected waste data of the agricultural prescription.", "For example, the processing module extracts the expected output data and the expected waste data from the agricultural prescription, compares the output data to the expected output data, compares the expected waste data to the waste data, and indicates the unfavorable comparison when a difference of either comparison is greater than a difference threshold level (e.g., too little crop output, too much waste).", "The method continues at step 216 where the processing module identifies a settings template based on local settings of the combine.", "For example, the processing module receives the local settings from the combine and compares the received local settings to a plurality of settings templates to identify the settings template.", "The method continues at step 218 where the processing module issues a settings alert that includes the settings template to a managing user device.", "For example, the processing module generates the settings alert to include one or more of the settings template and the difference of the unfavorable comparison.", "The method continues at step 220 where the processing module obtains an updated agricultural prescription.", "For example, the processing module sends one or more of the output data and the waste data to an application unit and receives the updated agricultural prescription.", "As another example, the processing module generates the updated agricultural prescription based on one or more of the agricultural prescription, the output data, the waste data, and the sensor data.", "For instance, the processing module generates updated control information to affect one or more settings of the combine to improve output and reduce waste.", "The method continues at step 222 where the processing module facilitates execution of the updated agricultural prescription within the local resource.", "For example, the processing module overwrites local settings with the updated control information of the updated agricultural prescription.", "FIG.", "15A is a schematic block diagram of another embodiment of a computing system that includes the geographic region 1 of FIG.", "1, the wireless communication network 1 of FIG.", "1, the network 24 of FIG.", "1, the user device 14 of FIG.", "5, the application unit 16 of FIG.", "5, and the storage unit 36 of FIG.", "5.The geographic region 1 includes associated user devices 1-1A, and 1-1C of FIG.", "1, with a planter actuator set 1A.", "The geographic region 1 may further include a user device 1-1B to provide communication and processing of information between the user device 1-1C and the user device 1-1A in a similar fashion as user device 2-1B provides processing and communication between user devices 2-1C and 2-1A of FIG.", "12A.", "The user device 1-1A includes sensors 190, the application processing module 34 of FIG.", "4, and the wireless communication modem 1 of FIG.", "4.The sensors 190 include at least some of the sensors 1-7 of FIG.", "7.The user device 1-1A traverses portions of a drive path 1 within the geographic region 1 in accordance with an agricultural prescription 1.The computing system is operable to identify an unfavorable crop planting level.", "In an example of operation of the identifying of the unfavorable crop planting level, the user device 1-1A facilitates execution of the prescription 1 with regards to planting a crop.", "For example, the user device 1-1A receives the prescription 1 from the wireless communication modem 1, where the application unit 16 sends, via the network 24, the prescription 1 to the wireless communication network 1, where the wireless communication network 1 sends wireless communication signals 42, that includes the prescription 1, to the user device 1-1C, and where the user device 1-1C issues further wireless communication signals 42, that includes the prescription 1, to the wireless communication modem 1.Having received the prescription 1, the application processing module 34 of the user device 1-1A issues control information 242 to the planter actuator set 1A based on the prescription 1.The control information 242 may include one or more settings for the planter.", "The settings include one or more of population, speed, depth, and downforce pressure.", "The planter actuator set 1A may further operate in accordance with local settings 240 provided by an operator of the planter.", "As such, the planter operates in accordance with one or more of the local settings 240 and the control information 242.Having issued the control information 242 to the planter actuator set 1A, the application processing module 34 interprets sensor data 192 of the sensors 190 and planter status 244 to generate error data 246 as task execution data.", "The error data 246 includes a difference between actual in desired planting rates.", "The application processing module 34 sends one or more of the sensor data 192 and the error data 246 as data sets for region 1 to the storage unit 36 for storage and subsequent delivery as data records 1 to the application unit 16 for further processing.", "When the error data 246 compares unfavorably to expected error data of the prescription 1, the application processing module 34 of the user device 1-1A facilitates corrective action.", "The facilitating includes selecting the action and executing the selected action.", "The selecting may be based on one or more of a predetermination, instructions extracted from the prescription 1, guidance 72 from the user device 14, and a magnitude level of the unfavorable comparison.", "The actions includes identifying a settings template 248 based on the local settings 240, issuing a settings alert 250 to one or more of the user device 14 and the storage unit 36, and executing another prescription (e.g., prescription 2) received from the application unit 16 and/or determined by the user device 1-1A based on the prescription 1.For example, the prescription 2 may include corrective action to override the local settings 240 with new control information 242 to optimize the error data 246.FIG.", "15B is a flowchart illustrating an example of identifying an unfavorable crop planting level.", "The method begins or continues at step 260 where a processing module (e.g., of an agricultural resource user device) facilitates execution of an agricultural prescription within a local resource that includes a planter to plant crops.", "For example, the processing module issues control information to a planter actuator based on the agricultural prescription.", "While executing the agricultural prescription, the method continues at step 262 where the processing module interprets sensor data and planter status to generate error data associated with planting crops.", "The interpreting includes determining a level of crop planting based on the planter status and the sensor data, and determining a difference between the level of crop planting and a desired level of crop planting from the agricultural prescription as the error data.", "The method continues at step 264 where the processing module detects an unfavorable comparison of the error data with expected error data of the agricultural prescription.", "For example, the processing module extracts the expected error data from the agricultural prescription, compares the error data to the expected error data, and indicates the unfavorable comparison when a difference of the comparison is greater than a difference threshold level (e.g., too little crop planted, too much crop planted).", "The method continues at step 266 where the processing module identifies a settings template based on local settings of the planter.", "For example, the processing module receives the local settings from the planter and compares the received local settings to a plurality of settings templates to identify the settings template.", "The method continues at step 268 where the processing module issues a settings alert that includes the settings template to a managing user device.", "For example, the processing module generates the settings alert to include one or more of the settings template and the difference of the unfavorable comparison.", "The method continues at step 270 where the processing module obtains an updated agricultural prescription.", "For example, the processing module sends the error data to the application unit and receives the updated agricultural prescription.", "As another example, the processing module generates the updated agricultural prescription based on one or more of the agricultural prescription, the error data, and the sensor data.", "For instance, the processing module generates updated control information to affect one or more settings of the planter to improve planting accuracy.", "The method continues at step 272 where the processing module facilitates execution of the updated agricultural prescription within the local resource.", "For example, the processing module overwrites local settings with the updated control information of the updated agricultural prescription.", "FIG.", "16A is a schematic block diagram of another embodiment of a computing system that includes the geographic region 1 of FIG.", "1, the wireless communication network 1 of FIG.", "1, the network 24 of FIG.", "1, the user device 14 of FIG.", "5, the application unit 16 of FIG.", "5, and the storage unit 36 of FIG.", "5.The geographic region 1 includes associated user devices 1-1A, and 1-1C of FIG.", "1, with an applicator actuator set 1A.", "The geographic region 1 may further include a user device 1-1B to provide communication and processing of information between the user device 1-1C and the user device 1-1A in a similar fashion as user device 2-1B provides processing and communication between user devices 2-1C and 2-1A of FIG.", "12A.", "The user device 1-1A includes sensors 190, the application processing module 34 of FIG.", "4, and the wireless communication modem 1 of FIG.", "4.The sensors 190 include at least some of the sensors 1-7 of FIG.", "7.The user device 1-1A traverses portions of a drive path 1 within the geographic region 1 in accordance with an agricultural prescription 1.The computing system is operable to identify an unfavorable applicant application level.", "The applicant includes any one of a solid, a liquid, and a gas applied to one or more portions of a geographic region associated with an agricultural lifecycle.", "Examples of the applicant includes fertilizer, fungicide, pesticide, and water.", "In an example of operation of the identifying of the unfavorable applicant application level, the user device 1-1A facilitates execution of the prescription 1 with regards to applying the applicant.", "For example, the user device 1-1A receives the prescription 1 from the wireless communication modem 1, where the application unit sends, via the network 24, the prescription 1 to the wireless communication network 1, where the wireless communication network 1 sends wireless communication signals 42, that includes the prescription 1, to the user device 1-1C, and where the user device 1-1C issues further wireless communication signals 42, that includes the prescription 1, to the wireless communication modem 1.Having received the prescription 1, the application processing module 34 of the user device 1-1A issues control information 282 to the applicator actuator set 1A based on the prescription 1.The control information 282 may include one or more settings for the applicator.", "The settings includes one or more of the volume of applicant per unit of area, volume of applicant per linear distance, speed, and volume of applicant applied over a given time frame.", "The planter actuator set 1A may further operate in accordance with local settings 280 provided by an operator of the applicator.", "As such, the applicator operates in accordance with one or more of the local settings 280 and the control information 282.Having issued the control information 282 to the applicator actuator set 1A, the application processing module 34 interprets sensor data 192 from the sensors 190 and applicator status 284 to generate error data 286 as task execution data.", "The error data 286 includes a difference between actual and desired application rates.", "The application processing module 34 sends one or more of the sensor data 192 and the error data 286 as data sets for region 1 to the storage unit 36 for storage in the memory 58 and subsequent delivery as data records 1 to the application unit 16 for further processing.", "When the error data 286 compares unfavorably to expected error data of the prescription 1, the application processing module 34 of the user device 1-1A facilitates corrective action.", "The facilitating includes selecting the action and executing the selected action.", "The selecting may be based on one or more of a predetermination, instructions extracted from the prescription 1, guidance 72 from the user device 14, and a magnitude level of the unfavorable comparison.", "The actions include identifying a settings template 288 based on the local settings 280, issuing a settings alert 290 to one or more of the user device 14 and the storage unit 36, and executing another prescription (e.g., prescription 2) received from the application unit 16 and/or determined by the user device 1-1A based on the prescription 1.For example, the prescription 2 may include corrective action to override the local settings 280 with new control information 282 to optimize the error data 286.FIG.", "16B is a flowchart illustrating an example of identifying an unfavorable applicant application level.", "The method begins or continues at step 300 where a processing module (e.g., of an agricultural resource user device) facilitates execution of an agricultural prescription within a local resource that includes an applicator to apply the applicant.", "For example, the processing module issues control information to an applicator actuator based on the agricultural prescription.", "While executing the agricultural prescription, the method continues at step 302 where the processing module interprets sensor data and applicator status to generate error data associated with applying the applicant.", "The interpreting includes determining a level of application of the applicant based on the applicator status and the sensor data, and determining a difference between the level of application of the applicant and a desired level of application of the applicant from the agricultural prescription as the error data.", "The method continues at step 304 where the processing module detects an unfavorable comparison of the error data with expected error data of the agricultural prescription.", "For example, the processing module extracts the expected error data from the agricultural prescription, compares the error data to the expected error data, and indicates the unfavorable comparison when a difference of the comparison is greater than a difference threshold level (e.g., too little applicant applied, too much applicant applied).", "The method continues at step 306 where the processing module identifies a settings template based on local settings of the applicator.", "For example, the processing module receives the local settings from the applicator and compares the received local settings to a plurality of settings templates to identify the settings template.", "The method continues at step 308 where the processing module issues a settings alert that includes the settings template to a managing user device.", "For example, the processing module generates the settings alert to include one or more of the settings template and the difference of the unfavorable comparison.", "The method continues at step 310 where the processing module obtains an updated agricultural prescription.", "For example, the processing module sends the error data to the application unit and receives the updated agricultural prescription.", "As another example, the processing module generates the updated agricultural prescription based on one or more of the agricultural prescription, the error data, and the sensor data.", "For instance, the processing module generates updated control information to affect one or more settings of the applicator to improve applicant application accuracy.", "The method continues at step 312 where the processing module facilitates execution of the updated agricultural prescription within the local resource.", "For example, the processing module overwrites local settings with the updated control information of the updated agricultural prescription.", "FIG.", "17A is a schematic block diagram of another embodiment of a computing system that includes the geographic region 1 of FIG.", "1, the wireless communication network 1 of FIG.", "1, the network 24 of FIG.", "1, the user device 14 of FIG.", "5, the application unit 16 of FIG.", "5, and the storage unit 36 of FIG.", "5.The geographic region 1 includes associated user devices 1-1A, and 1-1C of FIG.", "1, with a sensors set 1A, an actuator set 1A, and an auxiliary resource 1A.", "The auxiliary resource 1A includes an agricultural lifecycle resource.", "Examples of the auxiliary resource includes a grain cart, a crop wagon, and a fertilizer container trailer.", "The geographic region 1 further includes associated user devices 1-2A, and 1-2C of FIG.", "1, with a sensors set 2A and a tillage actuator set 2A.", "The geographic region 1 may further include a user device 1-1B to provide communication and processing of information between the user device 1-1C and the user device 1-1A in a similar fashion as user device 2-1B provides processing and communication between user devices 2-1C and 2-1A of FIG.", "12A.", "The sensors sets 1A and 2A include at least some of the sensors 1-7 of FIG.", "7.The user devices 1-1A and 1-2A traverse portions of a drive path 1 within the geographic region 1 with respect to velocities A and B in accordance with one or more agricultural prescriptions.", "The computing system is operable to generate a tillage agricultural prescription.", "In an example of operation of the generating of the tillage agricultural prescription, the application processing module 34 of the application unit 16 (e.g., hereafter referred to interchangeably as the application unit) obtains data records 1 for the geographic region 1, where the data records 1 includes auxiliary data 1 and sensor data 1 from the user device 1-1A.", "The auxiliary data 1 includes one or more of an auxiliary resource type indicator (e.g., grain cart vs. crop wagon, etc.", "), an estimated weight of the auxiliary resource (e.g., in kilograms, in pounds; at different times, and average over a time frame), a tire pattern (e.g., number of tires, tire width, separation between adjacent tires, separation between front and rear tires, etc.", "), and an estimated soil compaction level (e.g., as a function of the auxiliary resource type, the estimated weight, the tire pattern, and estimated rainfall volume and timing).", "In an example of obtaining the auxiliary data 1, the application unit 16 receives data records 1 from the storage unit 36, where the storage unit 36 receives the auxiliary data 1, via the network 24 from the wireless communication network 1, where the wireless communication network receives wireless communication signals 42 from the user device 1-1C, and where the wireless communication signals 42 includes the auxiliary data 1.Having obtained the data records 1, the application unit 16 identifies a plurality of geographic region traversals by one or more auxiliary resources based on the auxiliary data 1.For example, the application unit 16 identifies the number of traversals by the user device 1-1A along the drive path 1, where each traversal includes the auxiliary resource 1A.", "For each traversal, the application unit 16 estimates a level of soil impact (e.g., compaction of the soil).", "The estimating may be based on one or more of the auxiliary resource type, the estimated weight, the tire pattern, and the estimated soil compaction level when available.", "As a specific example, the application processing module 34 of the application unit 16 applies a deterministic function (e.g., a hashing function, a hash-based message authentication code, a sponge function, a logical function, a mask generating function) to the auxiliary resource type, the estimated weight, and the tire pattern to produce the estimated level of soil impact along the drive path 1.As another specific example, the application processing module 34 of the application unit 16 performs a table lookup based on the auxiliary resource type, the estimated weight, and the tire pattern to produce the estimated level of soil impact along the drive path 1.Having generated the estimated level of soil impact levels for each traversal, the application unit generates an aggregate level of soil impact based on the plurality of traversals.", "For example, the application processing module 34 of the application unit 16 applies a further deterministic function to each of the estimated levels of soil impact for each traversal to produce the aggregate level of soil impact.", "Having generated the aggregate level of soil impact, the application unit 16 generates a tillage prescription 1 based on the aggregate level of soil impact in one or more of guidance 72 from the user device 14 (e.g., a desired level of soil compaction after tillage), the sensor data, historical summaries, and rainfall level information (e.g., where more rainfall lessons the compaction in accordance with a rainfall compaction impact estimator).", "Having generated the tillage prescription 1 the application unit sends, via the network 24 and the wireless communication network 1, the tillage prescription 1 to the user device 1-2A for execution within a geographic region 1 along the drive path 1 with velocity B, where the user device 1-2A issues control information to the tillage actuator set 2A to implement tillage steps in accordance with the aggregate level of soil impact.", "For example, the tillage steps include utilizing a higher than average level of downforce when the aggregate level of soil impact indicates a higher than average level of soil compaction.", "FIG.", "17B is a flowchart illustrating an example of generating a tillage agricultural prescription.", "The method begins or continues at step 320 where a processing module (e.g., of an application unit) obtains agricultural data records for a geographic region, where the records includes auxiliary resource data.", "For example, the processing module receives the agricultural data records from one or more user devices associated with one or more auxiliary resources.", "As another example, the processing module receives the agricultural data records from a storage unit in response to issuing a query.", "The method continues at step 322 where the processing module identifies a plurality of geographic region traversals by one or more auxiliary resources based on the agricultural data records.", "For example, the processing module analyzes the agricultural data records to identify sensor data associated with each traversal (e.g., including raw sensor data, GPS coordinates, and timing).", "For each traversal, the method continues at step 324 where the processing module determines a level of soil impact within the geographic region.", "For example, the processing module analyzes the auxiliary data associated with the traversal, where the auxiliary data includes a composite of an auxiliary resource type, and estimated weight, and a tire pattern indicator.", "For instance, the processing module identifies a composite pattern and performs a lookup based on the identified composite pattern to produce the level of soil impact.", "The method continues at step 326 where the processing module generates an aggregate level of soil impact based on the plurality of traversals.", "For example, the processing module determines additive effects of soil impact from each traversal along a common drive path.", "For instance, the processing module adds a deterministic function to provide the additive effects of a plurality of traversals along the common drive path.", "The method continues at step 328 where the processing module generates a tillage prescription based on the aggregate level of soil impact.", "For example, the processing module generates the tillage prescription based on one or more of a desired level of tillage, the sensor data, historical summaries, and estimated soil moisture based on rainfall information associated with the geographic region.", "The tillage prescription includes execution steps including one or more of speed, drive path, depth, and a number of traversals along a common drive path.", "The method continues at step 330 where the processing module issues the tillage prescription to a user device for utilization of one or more tillage execution steps within the geographic region.", "For example, the processing module sends the tillage prescription to the user device that is assigned to execute steps of the tillage prescription within the geographic region.", "As another example, the processing module sends the tillage prescription to a managing user device FIG.", "18A is a schematic block diagram of another embodiment of a computing system that includes the user device 1-1A of FIG.", "1, the sensors set 1A of FIG.", "17A, the actuator set 1A of FIG.", "13A, the user device 1-1C of FIG.", "1, the user device 1-2A of FIG.", "1, the sensors set 2A of FIG.", "17A, the actuator set 2A of FIG.", "13A, the user device 1-2C of FIG.", "1, the geographic regions 1-1, 1-2, and 1-3 of geographic region 1 of FIG.", "3, the wireless communication network 1 of FIG.", "1, the network 24 of FIG.", "1, the user device 14 of FIG.", "5, the application unit 16 of FIG.", "5, and the storage unit 36 of FIG.", "5.The computing system may further include a user device 1-1B to provide communication and processing of information between the user device 1-1C and the user device 1-1A in a similar fashion as user device 2-1B provides processing and communication between user devices 2-1C and 2-1A of FIG.", "12A.", "The user device 1-1A traverses a drive path 1 within the geographic regions 1-1 through 1-3 in accordance with one or more agricultural prescriptions.", "The computing system is operable to generate a scouting agricultural prescription.", "In an example of operation of the generating of the scouting of the agricultural prescription, the application processing module 34 of the application unit 16 obtains data records 1 associated with execution of a prescription 1 for one or more portions of a geographic region, where the data records 1 includes one or more of sensor data 1 and historical summaries.", "Hereafter, the application processing module 34 of the application unit may 16 be interchangeably referred to as the application unit 16.In an example of the obtaining, the application unit 16 receives the data records 1 from the storage unit, where the storage unit receives the sensor data 1, via the network 24, from the wireless communication network 1, where the wireless communication network 1 receives wireless communication signals 42 from the user device 1-1C, where the wireless communication signals 42 includes the sensor data 1, and where the user device 1-1A generates the sensor data 1 based on data from the sensors set 1A as the user device 1-1A executes the prescription 1.The prescription 1 includes execution steps associated with collecting the data within the geographic regions 1-1 through 1-3.The application unit 16 generates the prescription 1 based on previous data records 1 and guidance 72 from the user device 14.Having obtained the data records 1, the application unit 16 identifies a group of geographic regions associated with similar traits.", "The traits include one or more of soil conditions, moisture levels, crop yield rates, soil nutrient levels, geographic proximity, crop types, elevation, and terrain variance.", "As a specific example, the application unit 16 identifies geographic regions 1-1 through 1-3 as the group of associated regions when the geographic regions 1-1 through 1-3 share common crop types.", "Having identified the group of geographic regions with the similar traits, the application unit 16 selects one of the geographic regions for further data collection.", "The selecting may be based on one or more of a random selection, a round-robin approach, proximity of the geographic region to a farming resource (e.g., to a tractor, a farmer), and availability of the geographic region to the farming resource (e.g., ready for scouting).", "For example, the application unit 16 selects geographic region 1-3 when a distance between the geographic region 1-3 and the user device 1-2A is favorable (e.g., less than a distance threshold level).", "Having selected the geographic region, the application unit 16 facilitates collection of further data 1 from the selected geographic region 1-3.As a specific example, the application unit 16 generates an updated prescription 1 and sends the updated prescription 1 to user device 1-2A (e.g., an available resource within a favorable proximity of the selected geographic region), where the updated prescription 1 indicates to collect data along a drive path 2 within the selected geographic region 1-3.The user device 1-2A collects the further data 1.As a specific example of the collecting of the further data 1, the user device 1-2A collects data from the sensors set 2A as the further data 1 and sends the further data 1 to the application unit 16 (e.g., directly via the wireless communication network 1 and network or indirectly via the storage unit 36 as well).", "As another specific example of the collecting of the further data 1, the user device 1-2A receives manual data input for the selected geographic region.", "For instance, a farmer enters crop condition data and soil condition data into at least one of the user device 1-2C and the user device 1-2A after scouting the geographic region 1-3 in accordance with the updated prescription 1 along drive path 2.Having received the further data 1, the application unit 16 modifies the agricultural prescription 1 to produce a further updated prescription 1 for the group of geographic regions 1-1 through 1-3 based on the further data 1 and the prescription 1.Having produced the further updated prescription 1, the application unit 16 sends the further updated prescription 1 to the user device 1-1A for execution within the geographic regions 1-1 through 1-3.FIG.", "18B is a flowchart illustrating an example of generating a scouting agricultural prescription.", "The method begins or continues at step 340 where a processing module (e.g., of an application unit) obtains data records for one or more sub-geographic regions while an agricultural prescription is being executed.", "The data records include one or more of sensor data and historical summaries associated with the one or more sub-geographic regions.", "Such historical summaries may include one or more of a percentage of weeds killed, number of weeds killed, and timing of one or more growth stages for desired crops.", "The obtaining includes at least one of receiving the data records from one or more resources and acquiring from a storage unit.", "The method continues at step 342 where the processing module identifies a group of sub-geographic regions associated with similar traits.", "As a specific example, the processing module determines traits of the sub-geographic regions based on the data records and identifies sub-geographic regions associated with common traits where trait values of the common traits compare favorably to each other (e.g., within a trait threshold level).", "The method continues at step 344 where the processing module selects one sub-geographic region of the group of sub-geographic regions for further data collection.", "For example, the processing module identifies traits of a sub-geographic region that compares favorably to trait values of the group of sub-geographic regions.", "The method continues at step 346 where the processing module facilitates collection of the further data from the selected sub-geographic region.", "As a specific example, the processing module issues an updated prescription that includes one or more execution steps to collect further data from a primary user device and/or another user device associated with the selected sub-geographic region, and receives the further data.", "As another specific example, the processing module retrieves the further data from a storage unit.", "The method continues at step 348 where the processing module modifies the agricultural prescription for the group of sub-geographic regions to produce a further update a prescription based on the further data collected from the selected sub-geographic region.", "For example, the processing module determines changes to a plurality of steps associated with the agricultural prescription that, when executed, provide optimal results based on the further data.", "The method continues at step 350 where the processing module facilitates execution of the further updated prescription.", "For example, the processing module sends the further updated prescription to one or more user devices associated with the group of sub-geographic regions for execution.", "FIG.", "19A is a schematic block diagram of another embodiment of a computing system that includes the user device 1-1A of FIG.", "1, the sensors set 1A of FIG.", "17A, the actuator set 1A of FIG.", "13A, the user device 1-1C of FIG.", "1, the geographic regions 1-1 through 1-9 of geographic region 1 of FIG.", "3, the wireless communication network 1 of FIG.", "1, the network of FIG.", "1, the user device 14 of FIG.", "5, the application unit 16 of FIG.", "5, the storage unit 36 of FIG.", "5, and a weather forecast unit 358.In the user device 14, the application unit 16, and the storage unit 16 includes the application processing module 34 of FIG.", "4.The computing system may further include a user device 1-1B to provide communication and processing of information between the user device 1-1C and the user device 1-1A in a similar fashion as user device 2-1B provides processing and communication between user devices 2-1C and 2-1A of FIG.", "12A.", "The user device 1-1A traverses a drive path within the geographic regions 1-1 through 1-9 in accordance with an agricultural prescription 1.The weather forecast unit 358 includes one or more of a National Weather Service information server, a micro-cast information server, and a local weather computer.", "The computing system is operable to generate an updated agricultural prescription based on forecasted weather conditions.", "In an example of operation of the generating of the updated agricultural prescription, the application unit obtains associated data records 1 for an agricultural prescription 1 for a plurality of geographic regions.", "For example, the application unit receives data records 1 that includes sensor data 1 received from via user device 1-1C from the user device 1-1A as the user device 1-1A executes the prescription 1 along a drive path.", "The data records may include one or more of current speed, current location, and un-executed prescription steps.", "For example, the user device 1-1A send sensor data 1 to the storage unit 36 for storage in memory 58 for geographic region 1-2 when the user device 1-1A is currently operating within the geographic region 1-2 and collecting data via the sensors set 1A.", "Alternatively, or in addition to, other user devices may operate within the plurality of geographic regions and send further sensor data to the storage unit 36 providing further data records 1 to the application unit 16.Having obtained the data records 1, the application unit 16 identifies a resource executing steps of the agricultural prescription 1 based on one or more of guidance 72 from the user device 14 and the data records 1.For example, the application unit 16 identifies the user device 1-1A based on the sensor data 1 from the user device 1-1A that includes identity of the user device 1-1A.", "Having identified the resource executing the steps, the application unit 16 obtains weather data 1 for the plurality of geographic regions.", "For example, the application unit 16 receives further data records 1, where the application unit 16 receives further data records 1 from the storage unit 36, where the storage unit 36 receives weather data 1, via the network 24, from the weather forecast unit 358.In an instance, the weather data 1 includes a micro forecast (e.g., real time and/or predicted weather conditions) for each of the geographic regions 1-1 through 1-9.Having obtained the weather data 1, the application unit 16 identifies pending un-executed steps of the agricultural prescription 1 associated with one or more geographic regions associated with unfavorable weather data.", "The identifying includes detecting the unfavorable weather data from the weather data 1 and correlating the unfavorable weather data with one or more of the geographic regions (e.g., by location and time).", "As a specific example, the application unit identifies geographic regions 1-6, 1-8, and 1-9 associated with the unfavorable weather data in the next 15 minutes and identifies steps of the agricultural prescription 1 to collect sensor data within the identified geographic regions 1-6, 1-8, and 1-9.Having identified the pending steps associated with the unfavorable weather, the application unit 16 modifies the agricultural prescription 1 regarding the pending steps to produce an updated agricultural prescription 1, where the update includes one or more of a change is speed, and updated right path to avoid the one or more geographic regions with the unfavorable weather data, and a suspension of one or more execution steps.", "As a specific example, the application unit modifies the prescription 1 to suspend steps associated with geographic regions 1-3, 1-6, 1-8, and 1-9, while updating the drive path and speed to move from geographic region 1-2 to geographic regions 1-5, 1-4, and 1-7 to perform un-executed steps associated with the geographic regions 1-2, 1-5, 1-4, and 1-7.Having modified the agricultural prescription 1 to produce the updated agricultural prescription 1, the application unit 16 sends, via the network 24 and the wireless communication network 1 using wireless communication signals 42, the updated prescription 1 to the user device 1-1A for immediate execution to avoid the predicted unfavorable weather.", "FIG.", "19B is a flowchart illustrating an example of generating an updated agricultural prescription based on forecasted weather conditions.", "The method begins or continues at step 360 where a processing module (e.g., of an application unit) obtains data records associated with an agricultural prescription for a plurality of sub-geographic regions.", "As a specific example, the processing module recovers the data records from a storage unit.", "As another example, the processing module receives sensor data from a resource executing steps of the agricultural prescription within at least one of the plurality of sub-geographic regions.", "The method continues at step 362 where the processing module identifies a resource that is executing steps of the agricultural prescription based on the data records.", "For example, the processing module interprets the data records to identify a resource associated with current execution of the agricultural prescription as the identified resource.", "The method continues at step 364 where the processing module obtains weather data for the plurality of sub-geographic regions.", "As a specific example, the processing module determines an identity of the plurality of sub-geographic regions and receives the weather data based on the identity of the plurality of sub-geographic regions.", "The method continues at step 366 where the processing module identifies pending steps of the agricultural prescription associated with one or more sub-geographic regions with unfavorable weather data.", "As a specific example, the processing module identifies one or more areas associated with an unfavorable weather forecast (e.g., rain, high winds, conditions unfavorable for execution of steps of the agricultural prescription, etc.)", "and interprets the agricultural prescription to identify the pending steps associated with the one or more identified areas.", "The method continues at step 368 where the processing module modifies the agricultural prescription with regards to the one or more pending steps to produce an updated agricultural prescription.", "The processing module performs the update to include one or more of changing speed of a current product path, generating an updated drive path to avoid the one or more areas associated with the unfavorable weather forecast while executing steps in areas associated with the favorable weather forecast.", "The method continues at step 370 where the processing module facilitates execution of the updated agricultural prescription by the resource.", "As a specific example, the processing module sends the updated agricultural prescription to the resource for execution of steps associated with the updated agricultural prescription.", "Alternatively, or in addition to, the processing module sends the updated agricultural prescription as an alert to the user device and/or to other user devices associated directly with the plurality of sub-geographic regions.", "The sending of an updated agricultural prescription may include sending the agricultural prescription to one or more user devices associated with a common geographic region to facilitate one or more of execution of steps associated with the updated agricultural prescription, based on awareness of assignments of the one or more execution steps to specific user devices, and awareness of a condition and/or status of previous execution of steps of the agricultural prescription and/or status of any attribute associated with the common geographic region.", "FIG.", "20A is a schematic block diagram of another embodiment of a user device that includes the controller area network (CAN) bus interface 110 of FIG.", "12B, the computing unit 26 of FIG.", "5, and the Bluetooth wireless location modem 1 of FIG.", "12B.", "Alternatively, at least one of a Wi-Fi indication modem, a 60 GHz communication modem, an infrared communication modem, any other wireless connectivity wireless communication modem, and a wireline interface (e.g., a universal serial bus (USB) interface) may be utilized in lieu of the Bluetooth wireless communication modem 1.The computing unit 26 includes the application processing module 34 of FIG.", "5 and the memory 58 of FIG.", "5.Alternatively, or in addition to, the user device 2-1B may include an on-board diagnostics (OBD) interface.", "The user device 2-1B is operable to facilitate the collecting of data (e.g., sensor data, location data, time data) to generate an agricultural prescription.", "In an example of operation of the facilitating of the collecting of the data to generate the agricultural prescription, the Bluetooth wireless communication modem 1 interprets Bluetooth wireless communication signals 116 from the user device 2-1C to produce wireless messages 1, where the wireless messages 1 have been encoded with one or more agricultural prescriptions.", "The application processing module 34 extracts the one or more prescriptions from the wireless messages 1 and stores the one or more prescriptions in the memory 58.Having received the one or more prescriptions, the CAN bus interface 110 receives CAN data 114 from the user device 2-1A to produce interface information 40.The application processing module 34 interprets the interface information 40 to produce raw sensor data sets.", "For example, the application processing module 34 decodes the interface information 40 in accordance with a CAN industry standard to produce the raw sensor data sets.", "Having produced the raw sensor data sets, the application processing module 34 obtains location information 1 from the user device 2-1A.", "The location information 1 includes one or more of coordinated universal time (UTC) and GPS coordinates, where the user device 2-1A receives GPS wireless location signals 1 and generates the location information 1 based on the received GPS wireless location signals 1.As a specific example, at least one of the CAN bus interface 110 and the computing unit 26 receives the location information 1 from the user device 2-1A.", "As another specific example, the CAN bus interface 110 receives further CAN data 114 that includes the location information 1 and interprets the further CAN data 114 to produce further interface information 40 that includes the location information 1.The user device 2-1A utilizes at least one of extracted UTC and local time associated with at least one of the user device 2-1A and the user device 2-1C to facilitate associating of sensor data with GPS coordinates and timestamps.", "Having received the location information 1, the application processing module receives location information 2 from the user device 2-1C.", "As a specific example, the application processing module 34 interprets further wireless messages 1 that includes the location information 2, where the Bluetooth wireless communication modem 1 receives further Bluetooth wireless communication signals 116 that includes the location information 2 from the user device 2-1C, and where the user device 2-1C receives GPS wireless location signals 2 and generates the location information 2 based on the received GPS wireless location signals 2.As another specific example of receiving the location information 2, the application processing module 34 receives the location information 2 from the Bluetooth wireless communication modem 1, where the Bluetooth wireless communication modem 1 receives the further Bluetooth wireless communication signals 116 from the user device 2-1C, where the further Bluetooth wireless communication signals 116 includes the location information 2.Having received the location information 1 and 2, the application processing module 34 generates error information associated with the location information 1 and 2 and selects at least one of the location information 1 and 2 based on the error information to produce location information.", "The selecting of the at least one of the location information 1 and 2 is discussed in greater detail with reference to FIG.", "20B.", "Having produced the location information, the application processing module 34 associates the raw sensor data sets with the location information to produce location enabled sensor data sets.", "For example, the application processing module tags sensor data with corresponding UTC and GPS location coordinates of time of receipt to produce the location enabled sensor data sets.", "Having produced the location enabled sensor data sets, the application processing module 34 stores the location enabled sensor data sets in the memory 58.The application processing module 34 identifies at least one prescription of the one or more prescriptions associated with the location information.", "For example, the application processing module 34 identifies a geographic location area associated with the prescription that is substantially the same as the obtained location information.", "Having identified the prescription, the application processing module 34 associates the identified prescription with the location enabled sensor data sets to produce prescription based location enabled sensor data sets.", "For example, the application processing module 34 tags the location enabled sensor data sets with an identifier of the identified prescription to produce the prescription based location enabled sensor data sets.", "Having produced the prescription based location enabled sensor data sets, the application processing module 34 may perform a filtering function on the prescription based location enabled sensor data sets in accordance with a filter identifier of the identified prescription to produce sensor data sets.", "For example, the application processing module 34 discards one or more portions of sensor data and not associated with the prescription.", "Alternatively, the application processing module 34 applies a null filter to prevent discarding any sensor data.", "The application processing module 34 generates still further wireless messages 1 based on the sensor data sets.", "Having produced the still further wireless messages 1, the application processing module 34 sends the still further wireless messages 1 to the Bluetooth wireless communication modem 1 for transmission to the user device 2-1C for retransmission via fourth-generation (4G) wireless communication signals 118 to a storage unit for storage and subsequent processing to produce at least one of an updated agricultural prescription and a new agricultural prescription.", "FIG.", "20B is a schematic block diagram of an embodiment of the application processing module 34 of FIG.", "20A that includes a location information error module 380, a location information switching module 382, an interpretation module 384, and a storage module 386.The application processing module 34 functions to generate error information associated with the location information 1 and 2 and selects at least one of the location information 1 and 2 based on the error information to produce location information for storage.", "In an example of operation, the interpretation module 384 interprets the interface information 40 to produce sensor data sets.", "As a specific example, the interpretation module 384 decodes the interface information 40 in accordance with an industry CAN standard to produce the raw sensor data 390.The location information error module 380 analyzes the location information 1 and 2 to generate generates error information 1, 2.The analyzing includes one or more of detecting a signal dropout, estimating a location accuracy, comparing the location accuracy to one or more accuracy threshold levels, identifying a number of received satellites, generating a likelihood of spoofing level, and estimating a time accuracy.", "The analyzing may further include comparing a first portion of location information 1 to another portion of location information 2 and comparing the first portion of location information 1 to a first portion of the location information 2.The location information switching module 382 selects at least one of the location information 1 and location information 2 based on the error information 1, 2 to produce location information 388 (e.g., composite location information as discussed with reference to FIG.", "12B).", "The selecting may be in accordance with a selection approach.", "The selection approach includes one or more of selecting an error free signal, selecting a signal with a lowest level of errors, selecting a signal with a level of errors below a low error threshold level, selecting both, selecting either, combining to produce a lower net error level, and interleaving.", "The storage module 386 combines the location information 388 and the raw sensor data 390 to produce location enabled sensor data 392 for storage in the memory 58.As a specific example, the storage module 386 tags a first portion of the raw sensor data with a first portion of the location information, where absolute timing information is substantially the same for the first portions.", "FIG.", "20C is a flowchart illustrating an example of opportunistic acquisition of location information enabling data collection to generate an agricultural prescription, that include similar steps to FIG.", "12C.", "The method begins or continues with the steps 140-142 of FIG.", "12C where a processing module (e.g., an application processing module of a user device) obtains one or more agricultural prescriptions and interprets received data to produce raw sensor data sets of a current geographic region.", "The method continues at step 410 where the processing module obtains location information of the current geographic region from two or more sources.", "For example, the processing module interprets the received data to extract the location information.", "As another example, the processing module receives further location information from another user device.", "The method continues at step 412 where the processing module determines error information for the location information of each of the two or more sources.", "For example, the processing module analyzes the location information to identify one or more error conditions (e.g., location dropouts, unfavorable location accuracy, too few satellites, etc.).", "The method continues at step 414 where the processing module processes the location information of the two or more sources based on the error information to produce location information.", "The processing includes at least one of selecting and combining to provide a location accuracy level greater than a minimum accuracy threshold level.", "The method continues with steps 146-152 of FIG.", "12C where the processing module associates the raw sensor data sets with the obtained location information to produce location enabled sensor data sets, stores the location enabled sensor data sets in the local memory, identifies at least one agricultural prescription associated with the location information, and associates the identified agricultural prescription with the location enabled sensor data sets to produce prescription based location enabled sensor data sets.", "The method may further continue with steps 154-156 of FIG.", "12C where the processing module performs a filtering function on the prescription based location enabled sensor data sets in accordance with a filter identifier of the identified agricultural prescription to produce sensor data sets for the current geographic region and sends the sensor data sets to a storage unit for storage and subsequent processing of the sensor data sets to produce at least one of an updated prescription and a new prescription.", "FIG.", "21A is a schematic block diagram of another embodiment of a computing system that includes associated user devices 1-1A, and 1-1C of FIG.", "1, a gyro sensor set 1A, and a tillage actuator set 1A, the geographic region 1 of FIG.", "1, the wireless communication network 1 of FIG.", "1, the network 24 of FIG.", "1, the user device 14 of FIG.", "5, the application unit 16 of FIG.", "5, the storage unit 36 of FIG.", "5, and the weather forecast unit 358 of FIG.", "19A.", "The computing system may further include a user device 1-1B to provide communication and processing of information between the user device 1-1C and the user device 1-1A in a similar fashion as user device 2-1B provides processing and communication between user devices 2-1C and 2-1A of FIG.", "12A.", "The sensors include at least some of the sensors 1-7 of FIG.", "7.The user device 1-1A traverses portions of a drive path 1 within a geographic region 1 in accordance with an agricultural prescription 1 at various times 1, 2, etc.", "through time x.", "The computing system is operable to generate a nitrogen application agricultural prescription.", "In an example of operation of generating the nitrogen application agricultural prescription, the application processing module 34 of the application unit 16 obtains data records 1 for the geographic region 1, where the data records 1 includes sensor data 1 from the user device 1-1A collected at various times from transversals of the geographic region 1.The sensor data 1 includes one or more of gyro data 1, tillage data 1, image data 1, and planter data 1.The gyro data 1 includes one or more of gyroscope output data (e.g., acceleration, velocity, distance, pitch, yaw, etc.)", "and location information (e.g., GPS coordinates, timestamp information).", "The tillage data 1 includes torque level data.", "The planter data 1 includes further torque level data.", "The image data 1 includes soil images.", "The obtaining of the data records 1 includes at least one of receiving the data records 1 from the storage unit 36 and interpreting received sensor data 1, where the application processing module 34 receives the sensor data 1 directly from the user device 1-1A.", "Having obtained the data records 1, the application processing module 34 of the application unit 16 interprets the data records 1 to produce composite torque levels based on the tillage data and the planter data.", "For instance, the application processing module 34 produces a time stamped torque level histogram for each transversal.", "Having produced the composite torque levels, the application processing module 34 of the application unit 16 interprets the data records 1 to produce bare soil images based on the image data.", "For instance, the application processing module produces time stamped images along each transversal, where the time stamped images include image of the soil of the geographic region along the drive path.", "Having produced the bare soil images, the application processing module 34 of the application unit 16 interprets the data records 1 to produce a topographic map for the geographic region 1.For example, the application processing module 34 interprets the gyroscope output and location information to produce linear elevation data along each transversal and aggregates the linear elevation data along the transversals to produce the topographic map for the geographic region 1.Alternatively, the application processing module 34 of the application unit 16 receives the topographic map from the storage unit 36 and/or from another server.", "Further alternatively, the application processing module 34 of the application unit 16 utilizes location information from the user device 1-1A to produce the topographic map, where the GPS coordinates of the location information includes z direction information for elevation.", "Having obtained the topographic map, the application processing module 34 of the application unit 16 interprets weather data 1 to produce rainfall data for the geographic region 1 (e.g., timing for amounts of rain for one or more portions of the geographic region 1).", "As a specific example, the application processing module 34 receives, via the network 24, the weather data 1 from the weather forecast unit 358, where weather data 1 includes rainfall history for the geographic region 1.Having produced the rainfall data, the application processing module 34 of the application unit 16 analyzes the bare soil images and the composite torque levels to determine an amount of organic material associated with portions of the geographic region 1.As a specific example, the application processing module 34 compares a series of bare soil images of a portion of the geographic region 1 to a plurality of template soil images to identify a corresponding template image and compares a series of composite torque levels of the portion of the geographic region 1 to a plurality of template torque levels to identify a corresponding template torque level.", "Having identified the template image and template torque level for the portion, the application processing module 34 performs a lookup to determine the amount of organic material for the portion based on the identified template image and template torque level.", "Having produced the amount of organic material associated with portions of the geographic region 1, the application processing module of the application generates a nitrogen application prescription as an updated prescription 1 based on one or more of guidance 72 from the user device 14 (e.g., an instruction to produce the nitrogen application prescription), the amount of organic material associated with the portions, the topographic map, and the rainfall data.", "As a specific example, the application processing module 34 determines a gradient along the drive path 1 based on the topographic map and performs a deterministic function on the amount of organic material, the gradient, and the rainfall data to produce and intermediate result.", "Having produced the intermediate result, the application processing module 34 performs a lookup using the intermediate result to produce an amount of nitrogen to apply to a portion corresponding to the gradient.", "Having produced the updated prescription 1, the application processing module 34 of the application unit 16 facilitates execution of the updated prescription 1.As a specific example, the application processing module 34 of the application unit 16 sends, via the network 24, the updated prescription 1 to the user device 14 and via the wireless communication network 1 using the wireless communication signals 42 to the user device 1-1C such that at time x the user device 1-1A issues control information to the nitrogen actuator set 1A, where the nitrogen actuator set 1A applies the amount of nitrogen along the drive path 1 in accordance with the updated prescription 1.FIG.", "21B is a flowchart illustrating an example of generating a nitrogen application agricultural prescription.", "The method begins or continues at step 440 where a processing module (e.g., of an application processing module of an application unit) obtains associated data records for a plurality of transfer cells of a geographic region associated with an agricultural prescription.", "For example, the processing module receives the data records directly from a user device.", "As another example, the processing module receives the data records from a storage unit.", "The data records include one or more of image data, tillage data, planter data, gyro data, and location information.", "The method continues at step 442 where the processing module interprets the data records to produce torque levels based on tillage data and planter data.", "For example, the processing module interprets one or more of the tillage data and the planter data to produce torque levels associated with portions of the geographic region.", "The method continues at step 444 where the processing module interprets the data records to produce bare soil images based on image data.", "For example, the processing module extracts bare soil images from the image data.", "The method continues at step 446 where the processing module obtains a topographic map for the geographic region.", "As a specific example, the processing module recovers the topographic map from the storage unit.", "As another specific example, the processing module generates the topographic map based on the gyro data and the location information.", "The method continues at step 448 for the processing module interprets weather data to produce rainfall data for the geographic region.", "As a specific example, the processing module extracts historical rainfall levels and timing of rainfall to produce the rainfall data.", "The method continues at step 450 where the processing module analyzes the bare soil images and the torque levels to determine an amount of organic material associated with a portion of the geographic region.", "As a specific example, the processing module compares the bare soil images with reference bare soil images to identify a substantially similar reference bare soil image and performs a lookup to determine an organic material level associated with the identified reference bare soil image.", "As another specific example, the processing module compares the torque levels with reference torque levels to identify a substantially similar reference torque level and performs a lookup of an organic material level associated with the identified reference torque level.", "The method continues at step 452 where the processing module generates a nitrogen application prescription as an updated prescription based on one or more of the amount of organic material, the topographic map, and the rainfall data.", "As a specific example, the processing module applies a deterministic function to the amount of organic material, topographic characteristics for a given portion of the geographic region from the topographic map, and the rainfall data to produce and intermediate result.", "The processing module accesses a nitrogen prescription table utilizing the intermediate result to recover a nitrogen level prescription for the given portion of the geographic region.", "The method continues at step 454 where the processing module facilitates execution of the updated prescription.", "As a specific example, the processing module sends the updated prescription to a user device to implement steps of the updated prescription with regards to the nitrogen prescription.", "FIG.", "22A is a schematic block diagram of another embodiment of a computing system that includes associated user devices 1-1A, and 1-1C of FIG.", "1, the sensors set 1A of FIG.", "17A, the tillage actuator set 1A of FIG.", "21A, the combine actuator set 1A of FIG.", "14A, the geographic region 1 of FIG.", "1, the wireless communication network 1 of FIG.", "1, the network 24 of FIG.", "1, the user device 14 of FIG.", "5, the application unit 16 of FIG.", "5, the storage unit 36 of FIG.", "5, and the weather forecast unit 358 of FIG.", "19A.", "The computing system may further include a user device 1-1B to provide communication and processing of information between the user device 1-1C and the user device 1-1A in a similar fashion as user device 2-1B provides processing and communication between user devices 2-1C and 2-1A of FIG.", "12A.", "The sensors include at least some of the sensors 1-7 of FIG.", "7.The user device 1-1A traverses portions of a drive path 1 within a geographic region 1 in accordance with an agricultural prescription 1 at various times 1, 2, etc.", "through time x.", "The computing system is operable to generate a harvest agricultural prescription.", "In an example of the generating of the harvest agricultural prescription, the application processing module 34 of the application unit 16 obtains data records 1 for the geographic region 1, where the data records 1 includes sensor data 1 from the user device 1-1A collected at various times from transversals of the geographic region 1.The sensor data 1 includes one or more of timestamped temperature levels, timestamped soil moisture levels, and time stamped soil nutrient levels.", "The obtaining of the data records 1 includes at least one of receiving the data records 1 from the storage unit 36 and interpreting received sensor data 1, where the application processing module 34 receives the sensor data 1 directly from the user device 1-1A.", "Having obtained the data records 1, the application processing module 34 of the application unit 16 obtains a unit of time (e.g., an hour, a minute) for an agricultural lifecycle, where a plurality of units of time range from a first unit of time to a present unit of time.", "The first unit of time corresponds to an initial planting of a crop.", "The present unit of time may refer to an intermediate time after planting but before harvesting.", "A future unit of time includes a time of harvesting.", "The obtaining of the unit of time includes at least one of selecting based on a predetermination (e.g., from the agriculture prescription 1), and determining that an expected variance level of growth factors is expected to be less than a variance threshold level.", "For each unit of time, the application processing module 34 of the application unit 16 determines values of a set of growth factors based on one or more of the data records 1 and weather data 1.The weather data 1 includes one or more of sunlight intensity level per unit time, temperature level per unit of time, and rainfall history for the geographic region 1.The application processing module 34 extracts the weather data 1 one from the data records 1.Alternatively, the application processing module 34 receives, via the network 24, the weather data 1 directly from the weather forecast unit 358.The growth factors include one or more of a sunlight intensity level, a temperature level, a soil moisture level, and a soil nutrient level.", "For example, the application processing module interprets the data records 1 to produce the soil moisture level and the soil nutrient level.", "As another example, the application processing module 34 interprets obtains the weather data 1 and interprets the weather data 1 to produce historical weather information (e.g., temperature per unit of time, sunlight intensity level per unit of time based on one or more of cloud cover and hours of sunlight based on the day of year for the geographic region 1).", "For each unit of time, the application processing module 34 of the application unit 16 applies a deterministic function to the set of growth factors to produce a corresponding predictive growth unit (PGU).", "As a specific example, the application processing module generates the PGU in accordance with a formula: PGU=a*sunlight level+b*temp+c*moisture level temperature level+d*nutrient where a, b, c, and d are constants associated with the set of growth factors.", "The application processing module 34 of the application unit 16 sums each corresponding PGU for the units of time from the first unit of time to the present unit of time to produce a current accumulated predictive growth metric (PGM).", "As a specific example, the application processing module generates the PGM in accordance with a formula: PGM=PGU1+PGU2+PGU3+through PGU current unit of time The application processing module 34 of the application unit 16 estimates a harvest ready unit of time based on one or more of a portion of the predictive growth units for at least some of the previous units of time (e.g., a trend), predictive values of growth factors for future units of time (e.g., based on history), and guidance 72 from the user device 14.As a specific example, the application processing module 34 estimates the harvest ready unit of time to be 10 days from the current unit of time when the PGM value is 2,457, a desired PGM harvest value is 3100, and an expected trend for the PGM is to move from 2,457 to 3,100 and 10 days based on historical data.", "Having estimated a harvest timeframe based on the harvest ready unit of time, the application processing module 34 of the application unit 16 generates an updated prescription 1 based on the prescription 1 and the estimated harvest timeframe, such that the updated prescription 1 includes harvest execution steps in 10 days.", "Having generated the updated prescription 1, the application processing module 34 of the application unit 16 sends, via the network 24, the updated prescription 1 to the user device 14 and further sends, via the wireless communication network 1 using wireless communication signals 42, the updated prescription 1 to the user device 1-1A such that the user device 1-1A issues control information to the combine actuator set 1A in accordance with a harvest prescription 1 portion of the updated prescription 1.FIG.", "22B is a flowchart illustrating an example of generating a harvest agricultural prescription.", "The method begins or continues at step 470 where a processing module (e.g., of an application processing module of an application unit) obtains associated data records for a plurality of traversals of a geographic region associated with an agricultural prescription.", "The obtaining includes at least one of receiving the data records directly from the user device and recovering the data records from a storage unit.", "The data records includes one or more of time stamped temperature levels, time stamped soil moisture levels, time stamped soil nutrient levels, and location information for each of the times and values.", "The method continues at step 472 where the processing module determines a unit of time for an agricultural lifecycle associated with the agricultural prescription.", "The determining may be based on one or more of a predetermination and a unit of time such that an expected variance level of growth factors is less than a variance threshold level.", "For each unit of time of the agricultural lifecycle, the method continues at step 474 where the processing module determines values of a set of growth factors based on one or more of the data records and weather data.", "The determining includes interpreting the data records to produce one or more of a soil moisture level and a soil nutrient level.", "The determining may further include interpreting the weather data to produce a temperature per unit of time and a sunlight intensity level per unit of time.", "For each unit of time, the method continues at step 476 where the processing module applies a deterministic function to the set of growth factors to produce a corresponding predictive growth unit.", "As a specific example, the processing module selects the deterministic function based on one or more of a predetermination, location information associated with the geographic region, a time of year, and an expected accuracy level.", "The processing module utilizes the selected deterministic function to manipulate the growth factors producing the predictive growth unit, where the deterministic function may include a combination of constants and deterministic mathematical functions.", "The method continues at step 478 where the processing module sums each predictive growth unit to produce a current accumulated predictive growth metric.", "As a specific example, the processing module adds values for a predictive growth unit associated with units of time 1 through a current unit of time to produce the current accumulated predictive growth metric.", "The method continues at step 480 where the processing module estimates a harvest ready timeframe based on one or more of a portion of the predictive growth units for at least some of the previous units of time and predictive values of growth factors for future units of time.", "As a specific example, the processing module interprets a trend from the portion of the predicted growth units and extends the trend based on the predicted values of growth factors for future units of time based on interpreting historical summaries.", "Alternatively, or in addition to, the processing module generates an updated agricultural prescription based on the agricultural prescription and the harvest ready timeframe and sends the updated agricultural prescription to a user device for execution, where the updated agricultural prescription includes harvest execution steps associated with the harvest ready timeframe.", "FIG.", "23A is a schematic block diagram of another embodiment of a computing system that includes the geographic region 1 of FIG.", "1, the wireless communication network 1 of FIG.", "1, the network 24 of FIG.", "1, the user device 14 of FIG.", "5, the application unit 16 of FIG.", "5, and the storage unit 36 of FIG.", "5.The geographic region 1 includes a harvest apparatus set 490 and user device 1-1C of FIG.", "1.The harvest apparatus set 490 includes the user device 1-1A of FIG.", "1, a sensors set 1A, a harvest actuator set 1A, and an auxiliary resource 1A.", "The geographic region 1 may further include a user device 1-1B to provide one or more of communication, processing, and discovery of other like proximal user devices, where the communication includes transfer of information between the user device 1-1C and the user device 1-1A in a similar fashion as user device 2-1B provides processing and communication between user devices 2-1C and 2-1A of FIG.", "12A.", "The user device 1-1A includes the application processing module 34 of FIG.", "4 and the wireless communication modem 1 of FIG.", "4.The sensors set 1A include at least some of the sensors 1-7 of FIG.", "7.The harvest actuator set 1A includes one or more actuators associated with at least one of a combine and any crop harvesting machine.", "The auxiliary resource 1A includes any other agricultural resource that may be associated with the harvest apparatus set such as one or more of a grain cart, a harvest crop wagon, a fertilizer transporter, a water transporter, etc.", "The user device 1-1A traverses portions of a drive path 1 within the geographic region 1 in accordance with an agricultural prescription 1.The computing system is operable to determine crop harvesting yield.", "In an example of operation of the determining of the crop harvesting yield, the application unit 16 (e.g., the application processing module 34 of the application unit 16) obtains data records 1 for the geographic region 1 where the agricultural prescription 1 is being executed by the harvest apparatus set 490, and where the application unit generates the agricultural prescription 1 based on guidance 72 from the device 14 (e.g., a primary user device).", "The obtaining includes at least one of receiving sensor data 1 from the harvest apparatus set 490 and receiving the data records 1 from the storage unit 36.For example, the user device 1-1C sends the sensor data 1, transmitting wireless communication signals 42 via the wireless location network 1, and via the network 24, to the storage unit 36 for storage in the memory 58 where the storage unit 36 aggregates the sensor data 1 and historical summaries (e.g., similar previously stored sensor data for the geographic region 1) to produce the data records 1, and where the storage unit 36 sends the data records 1, via the network 24, to the application unit 16.The sensor data 1 includes one or more of moisture data 1 (e.g., a moisture level for each of a plurality of locations), unloading auger data 1 (e.g., location information associated with auger activation, time duration of auger activation, auger revolutions per minute (RPM), estimated number of wet bushels unloaded per unit of time), and auxiliary data 1 (e.g., an auxiliary resource identifier, an auxiliary resource weight and timestamp).", "The data records 1 includes one or more of the unloading auger data, the moisture data, the auxiliary data, and historical summaries (e.g., a calibration of previous augur data and actual crop yield data).", "Having obtained the data records 1, the application unit 16 generates intermediate estimated yield data based on one or more of the data records 1 and guidance 72 from the user device 14 (e.g., desired yield data type, desired yield data units, etc.).", "For example, the application unit 16 determines an estimated number of wet bushels harvested per acre based on one or more of an amount of auger time of the unloading auger data and gross weight of a crop wagon extracted from the auxiliary data.", "Having generated the intermediate estimated yield data, the application unit 16 generates yield data 1 (e.g., bushels of crops per acre) based on the intermediate estimated yield data and one or more of the moisture data and the historical summaries.", "For example, the application unit 16 extracts the calibration from the historical summaries and utilizes the moisture data to update the estimated wet bushels to determine the yield data 1 based on the updated estimated wet bushels and the historical summaries for resulting non-wet bushels.", "Having generated the yield data 1, the application unit 16 sends the yield data 1 to one or more of a primary user device (e.g., user device 14) and the harvest apparatus set 490.For example, the application unit sends, via the network 24 and the wireless communication network 1, the yield data 1 to the user device 1-1C for transfer to the harvest apparatus set 490 for further processing and/or visualization by at least one of the user device 1-1A and the user device 1-1C.", "For instance, the user device 1-1C displays a map of the geographic region 1 where the map overlays the yield data (e.g., varying colors represent varying levels of yield).", "Having issued the yield data, the application unit 16 updates the agricultural prescription based on the yield data to produce another agricultural prescription 1 (e.g., an updated agricultural prescription 1), where the updated agricultural prescription 1 includes modifications to steps of the agricultural prescription to optimize harvesting based on the yield data.", "For instance, the modifications to the steps include updated control information for the harvest actuator set 1A.", "Having updated the agricultural prescription, the application unit sends, via the network and the wireless communication network 1, the updated agricultural prescription to one or more of the harvest apparatus set and the primary user device.", "FIG.", "23B is a flowchart illustrating an example of determining crop harvesting yield.", "The method begins or continues at step 500 where a processing module (e.g., an application processing module of at least one of an application unit and a user device), for an agricultural prescription of a geographic region, obtains data records associated with harvesting steps of the agricultural prescription, where the data records includes unloading auger data as a result of a harvesting step.", "The obtaining includes at least one of receiving the data records directly from a user device and recovering the data records from a storage unit.", "The data records include one or more of unloading auger data, moisture data, auxiliary data, and historical summaries.", "The method continues at step 502 where the processing module generates intermediate estimated yield data based on the data records.", "For example, the processing module, for a given portion of the geographic region, multiplies a number of seconds of unloading auger activation time by a number of wet bushels per second factor to generate the intermediate estimated yield data.", "The factor may be verified based on the auxiliary data that includes gross weight changes of harvested crops for the given portion of the geographic region.", "The method continues at step 504 where the processing module generates yield data based on the intermediate estimated yield data and one or more of moisture data and historical summaries.", "For example, the processing module, for the given portion of the geographic region, extracts a calibration from the historical summaries and multiplies the calibration by the number of wet bushels to produce the yield the data of non-wet bushels per acre.", "The method continues at step 506 where the processing module sends the yield data to one or more of a primary user device and a user device associated with the harvesting steps.", "For example, the processing module sends the yield data to a user device associated with the harvesting steps for operator display.", "The method continues at step 508 where the processing module updates the agricultural prescription based on the yield data to produce an updated agricultural prescription.", "For example, the processing module analyzes the yield data to update one or more steps of the agricultural prescription to favorably improve the yield data for subsequent determinations.", "The method continues at step 510 where the processing module facilitates execution of the updated agricultural prescription.", "For example, the processing module sends the updated prescription to a user device associated with execution of one or more agricultural prescriptions within the geographic region.", "FIG.", "24A is a schematic block diagram of another embodiment of a computing system that includes the geographic region 1 of FIG.", "1, the wireless communication network 1 of FIG.", "1, the network 24 of FIG.", "1, the user device 14 of FIG.", "5, the application unit 16 of FIG.", "5, and the storage unit 36 of FIG.", "5.The geographic region 1 includes harvest apparatus sets 1-2 and user device 1-1C and 1-2C of FIG.", "1.Each harvest apparatus set includes the user device 1-1A or 1-2A of FIG.", "1, a sensor set 1A or 2A, a harvest actuator set 1A or 2A, and an auxiliary resource 1A or 2A.", "The geographic region 1 may further include a user device 1-1B and/or 1-2B to provide one or more of communication, processing, and discovery of other like proximal user devices, where the communication includes transfer of information between the user device 1-1C and the user device 1-1A over the user device 1-2C and the user device 1-2A in a similar fashion as user device 2-1B provides processing and communication between user devices 2-1C and 2-1A of FIG.", "12A.", "The user devices 1-1A and 1-2A includes the application processing module 34 of FIG.", "4 and the wireless communication modem 1 of FIG.", "4.The sensors sets 1A and 2A include at least some of the sensors 1-7 of FIG.", "7.The harvest actuator sets 1A and 2A includes one or more actuators associated with at least one of a combine and any crop harvesting machine.", "The auxiliary resources 1A and 2A includes any other agricultural resource that may be associated with the harvest apparatus set such as one or more of a grain cart, a harvest crop wagon, a fertilizer transporter, a water transporter, etc.", "The user device 1-1A traverses portions of a drive path 1 within the geographic region 1 in accordance with an agricultural prescription 1 and the user device 1-2A traverses portions of a drive path 2 within the geographic region 1 in accordance with an agricultural prescription 2.The computing system is operable to optimize crop harvesting yield.", "In an example of operation of the optimizing of the crop harvesting yield, the application unit 16 (e.g., the application processing module 34 of the application unit 16) obtains harvest data records for a geographic region where one or more agricultural prescriptions are being executed by a plurality of harvest apparatus sets, and where the application unit 16 generates the one or more agricultural prescriptions (e.g., agricultural prescriptions 1-2) based on guidance 72 from the user device 14 (e.g., a primary user device).", "The obtaining includes at least one of receiving the harvest data records from the harvest apparatus sets 1-2 and receiving the harvest data records from the storage unit 36.For example, the user device 1-1C sends harvest sensor data 1, transmitting wireless communication signals 42 via the wireless location network 1, and via the network 24, to the storage unit 36 for storage in the memory 58 where the storage unit 36 aggregates the harvest data 1, harvest data 2 (e.g., from the harvest apparatus set 2) and the historical summaries (e.g., similar previously stored sensor data for the geographic region 1) to produce data records 1, 2, and where the storage unit 36 sends the data records 1, 2 via the network 24, to the application unit 16.The harvest data includes one or more of moisture data (e.g., a moisture level for each of a plurality of locations), unloading auger data (e.g., location information associated with auger activation, time duration of auger activation, auger revolutions per minute (RPM), estimated number of wet bushels unloaded per unit of time), and auxiliary data (e.g., an auxiliary resource identifier, an auxiliary resource weight and timestamp).", "The data records 1, 2 includes one or more of the unloading auger data, the moisture data, the auxiliary data, and historical summaries (e.g., a calibration of previous augur data and actual crop yield data).", "Having obtained the data records 1, 2, the application unit 16 generates, for each harvest apparatus set, yield data based on the data records 1, 2.For example, the application unit 16 determines an estimated wet bushels harvested per acre based on one or more of an amount of auger time of the unloading auger data 1 and gross weight of a crop wagon (e.g., aux resource 1A) extracted from auxiliary data 1 and generates non-wet bushels per acre harvested as yield data 1 based on a calibration for wet bushels harvested.", "Having generated the yield data 1, 2, the application unit 16 sends, for each harvest apparatus set, corresponding yield data to one or more of the primary user device 14 and the harvest apparatus set.", "For example, the application unit 16 sends, via the network 24 and the wireless communication network 1, the yield data 1 to the user device 1-1C for transfer to the harvest apparatus set 1 or further processing and/or visualization by at least one of the user device 1-1A and the user device 1-1C.", "For instance, the user device 1-1A displays a map of the geographic region 1 where the map overlays the yield data 1 (e.g., varying colors represent varying levels of yield).", "Similarly, user device 1-2C displays the map of the geographic region 1 where the map overlays the yield data 2 having received the yield data 2 from the application unit.", "Having sent the yield data, the application unit 16, for one or more of the agricultural prescriptions, updates the agricultural prescription based on all yield data to produce another agricultural prescription (e.g., an updated agricultural prescription), where the updated agricultural prescription includes modifications to steps of the agricultural prescription to optimize harvesting based on all of the yield data.", "For instance, the modifications to the steps of updated prescriptions 1-2 includes updated control information for the harvest actuator sets 1A and 2A.", "Having updated the agricultural prescription, the application unit 16 sends, via the network 24 and the wireless communication network 1, the updated agricultural prescriptions 1-2 to the harvest apparatus sets 1-2 and the primary user device 14.FIG.", "24B is a flowchart illustrating an example of optimizing crop harvesting yield.", "The method begins or continues at step 520 where a processing module (e.g., an application processing module of at least one of an application unit and a user device), for one or more agricultural prescriptions of a geographic region, obtains harvest data records associated with harvesting steps executed by a plurality of harvest apparatus sets.", "The obtaining includes at least one of receiving directly from a user device and recovering from a storage unit.", "The harvest data records include one or more of unloading auger data, moisture data, auxiliary data, and historical summaries.", "For each harvest apparatus set, the method continues at step 522 where the processing module generates corresponding yield data based on associated harvest data records.", "For example, for a given portion of the geographic region, the processing module multiplies a number of seconds of unloading auger activation by a number of wet bushels per second factor to estimate a number of wet bushels, and multiplies the number of estimated wet bushels by a calibration from historical summaries to produce non-wet bushels per acre harvested as the yield data.", "For each harvest apparatus set, the method continues at step 524 where the processing module sends the corresponding yield data to one or more of the harvest apparatus set and a primary user device.", "For example, the processing module sends the yield data to a user device associated with the harvesting steps for operator display to facilitate optimizing operation of the harvest apparatus set.", "For one or more of the agricultural prescriptions, the method continues at step 526 where the processing module updates the agricultural prescription based on all yield the data to produce one or more updated agricultural prescriptions.", "For example, the processing module compares harvest steps and corresponding yield data to identify harvest steps associated with favorable yield data and modifies a corresponding agricultural prescription to include the harvest steps associated with the favorable yield data.", "The method continues at step 528 where the processing module facilitates execution of any updated agricultural prescription.", "For example, the processing module sends the updated prescription to a user device to implement steps of the updated prescription with regards to achieving improved yields.", "FIG.", "25A is a schematic block diagram of another embodiment of a computing system that includes the geographic region 1 of FIG.", "1, the wireless communication network 1 of FIG.", "1, the network 24 of FIG.", "1, the user device 14 of FIG.", "5, the application unit 16 of FIG.", "5, and the storage unit 36 of FIG.", "5.The geographic region 1 includes a harvest apparatus set 1 and user device 1-1C of FIG.", "1.The harvest apparatus set 1 includes the user device 1-1A of FIG.", "1, sensors set 1A of FIG.", "23A, the harvest actuator set 1A of FIG.", "23A, and the auxiliary resource 1A of FIG.", "23A.", "The geographic region 1 may further include a user device 1-1B to provide one or more of communication, processing, and discovery of other like proximal user devices, where the communication includes transfer of information between the user device 1-1C and the user device 1-1A in a similar fashion as user device 2-1B provides processing and communication between user devices 2-1C and 2-1A of FIG.", "12A.", "The user device 1-1A includes the application processing module 34 of FIG.", "4 and the wireless communication modem 1 of FIG.", "4.The sensors set 1A include at least some of the sensors 1-7 of FIG.", "7.The harvest actuator set 1A includes one or more actuators associated with at least one of a combine and any crop harvesting machine.", "The auxiliary resource 1A includes any other agricultural resource that may be associated with the harvest apparatus set such as one or more of a grain cart, a harvested crop wagon, a fertilizer transporter, a water transporter, etc.", "The user device 1-1A traverses portions of a drive path 1_1 in a traversal direction within the geographic region 1 and traverses portions of a drive path 1_2 in an opposite traversal direction (e.g., adjacent to and in parallel with right path 1_1 but traversed in the opposite traversal direction) in accordance with an agricultural prescription 1.The computing system is operable to improve accuracy of crop harvesting sensor data from the harvest apparatus set 1.In an example of operation of the improving of the accuracy of the crop harvesting sensor data, at least one of the application unit 16 (e.g., the application processing module 34 of the application unit 16) and a user device (e.g., the user device 1-1A, the user device 1-1C) obtains harvest data records for at least two adjacent traversals of a portion of the geographic region 1 by the harvest apparatus set 1, where the harvest data records includes one or more of, by each of the plurality of locations within the portion of the geographic region (e.g., as indicated by location information), crop flow rate, crop moisture data, the auxiliary data, historical summaries, and an accuracy estimate (e.g., a confidence interval for a particular distance or time metric value).", "The historical summaries may include a calibration of previous auger data and actual yield data.", "For example, the application unit 16 receives data records 1 from the storage unit 36, where the storage unit 36 aggregates received harvest data 1_1, 1_2 (e.g., received via wireless communication signals 42 over the wireless location network 1 and via the network 24), and historical summaries retrieved from the memory 58 to produce the data records 1, and where the harvest apparatus set 1 issues the harvest data 1_1 to the storage unit 36 for storage in the memory 58 and the harvest apparatus set 2 issues the harvest data 1_2 to the storage unit 36.Having obtained the harvest data records, the application unit 16 updates the harvest data records to correct locations of sensor data measurements based on one or more of the guidance 72 from user device 14 and the harvest data records for the at least two adjacent traversals to produce corrected harvest data records.", "For example, the application unit 16 determines a time and/or distance-based adjustment factor that accounts for delays within harvesting equipment associated with the harvest actuator set and/or sensors set between a time of ingestion of a crop for harvesting and measuring of a particular metric of the harvest data.", "For example, a measurement of crop flow rate may be delayed by five seconds.", "As another example, a measurement of harvested crop moisture levels may be delayed by as much as 10 seconds.", "The updating of the harvest data records to correct locations of sensor data measurements is discussed in greater detail with reference to FIG.", "25B.", "Having produced the corrected harvest data records, the application unit 16 generates calibration data 1 based on the adjustment factor of the updating of the harvest data records.", "For example, the application unit determines a distance adjustment factor as the calibration data 1.As another example, the application unit determines a time adjustment factor as the calibration data 1.Having generated the calibration data 1, the application unit sends the calibration data 1 to the harvest apparatus set 1 to facilitate obtaining of improve accuracy harvest data records.", "FIG.", "25B is a diagram illustrating an example of correcting sensor data where measured sensor data magnitude 540 for a traversal direction 546 and an opposite traversal direction 548 is displayed by linear position 542 (e.g., along the traversal).", "In an example of the correcting of the sensor data, a data point from each of two or more measured sensor data (e.g., crop flow level) is identified that maximizes a likelihood of correlation to a common location area of a portion of a geographic region.", "For example, identifying matching data points 1 and 2 of the traversal direction curve and the opposite traversal direction curve.", "For each of the identified data points, associated positions corresponding to locations of the measured sensor data are identified (e.g., at two distances along the linear position).", "For each data point, an actual position is identified based on one or more of the identified positions of the data points, linear velocity of a sensor array measuring the sensor data while traversing the identified positions, and a relative processing speed associated with ingestion of a harvested crop (e.g., revolutions per minute (RPM) of a combine that draws the crop from the ground past one or more sensors such as a flowmeter and a moisture meter.", "For example, an actual position 1 is identified as corresponding to the position 1 and an actual position 2 is identified as corresponding to the position 2.In an instance, actual positions 1 and 2 may be substantially a common position along the linear position 542 when RPM levels and velocities associated with each of the traversals are substantially the same.", "Having identified the actual positions, a distance adjustment factor is determined for each traversal based on the identified actual position and an associate identified data point.", "For example, the distance adjustment factor associated with the opposite traversal direction is a difference between the actual position 1 and the position 1.Having determined the distance adjustment factor, the measured sensor data is updated for the portion of the geographic region based on the distance adjustment factors to produce corrected sensor data magnitude 544, where indicated linear positions correspond to actual positions rather than positions of the sensor array when the measurement was produced.", "FIG.", "25C is a flowchart illustrating an example of improving accuracy of crop harvesting sensor data.", "The method begins or continues at step 560 where a processing module (e.g., an application processing module of at least one of an application unit and a user device) obtains harvest data records for at least two adjacent traversals of a portion of a geographic region by a harvest apparatus set.", "The obtaining includes at least one of receiving the harvest data directly from a user device of the harvest apparatus set and recovering the harvest data records from a storage unit.", "The harvest data records include one or more of crop flow rate, crop moisture data, auxiliary data, and historical summaries.", "The method continues at step 562 where the processing module identifies data points from the at least two adjacent traversals correlated to a common location area.", "For example, the processing module identifies data points associated with uncorrected location information that is within the common location area with substantially the same sensor data.", "For each identified data point, the method continues at step 564 where the processing module identifies associated positions corresponding to locations of measured sensor data.", "For example, the processing module extracts uncorrected location information associated with the measured sensor data.", "The method continues at step 566 where the processing module determines an actual position of the common location area based on one or more of the identified positions of the data points, linear velocity of the harvest apparatus set, and a relative processing speed metric associated with ingestion of a harvested crop.", "The determining includes calculating an actual position between two data points.", "For example, the processing module determines the position to be in the middle of two data points when the velocities of opposite traversals are substantially the same.", "The method continues at step 568 where the processing module determines a distance adjustment factor based on the identified actual position of the common location area and an associated identified data point.", "For example, the processing module determines a distance from a data point to the middle of the two data points when the velocities are substantially the same.", "The method continues at step 570 where the processing module updates the measured sensor data of the portion of the geographic region based on the distance adjustment factor to produce corrected harvest data records.", "For example, the processing module adjusts the uncorrected the location information by the amount of the distance adjustment factor to produce corrected location information of the corrected harvest data records.", "The method continues at step 572 where the processing module generates crop yield data based on the corrected harvest data records.", "For example, the processing module interprets the corrected harvest data records to produce the crop yield data.", "The method continues at step 574 where the processing module generates calibration data based on the distance adjustment factor.", "For example, the processing module includes the distance adjustment factor in the calibration data.", "The method continues at step 576 where the processing module sends the calibration data to the harvest apparatus set to facilitate obtaining of subsequent harvest data records that includes improved accuracy sensor data.", "For example, the processing module includes the calibration data and instructions to utilize the calibration data to produce subsequent harvest data records with corrected location information and an indicator that the location information has been corrected.", "FIG.", "26A is a schematic block diagram of another embodiment of a computing system that includes the geographic region 1 of FIG.", "1, the wireless communication network 1 of FIG.", "1, the network 24 of FIG.", "1, the user device 14 of FIG.", "5, the application unit 16 of FIG.", "5, and the storage unit 36 of FIG.", "5.The geographic region 1 includes harvest apparatus sets 1-2 and user devices 1-1C and 1-2C of FIG.", "1.Each harvest apparatus set includes the user device 1-1A or 1-2A of FIG.", "1, the sensors set 1A or 2A of FIG.", "24A, the harvest actuator set 1A or 2A of FIG.", "24A, and the auxiliary resource 1A or 2A of FIG.", "24A.", "The geographic region 1 may further include a user device 1-1B and/or 1-2B to provide one or more of communication, processing, and discovery of other like proximal user devices, where the communication includes transfer of information between the user device 1-1C and the user device 1-1A over the user device 1-2C and the user device 1-2A in a similar fashion as user device 2-1B provides processing and communication between user devices 2-1C and 2-1A of FIG.", "12A.", "The user devices 1-1A and 1-2A includes the application processing module 34 of FIG.", "4 and the wireless communication modem 1 of FIG.", "4.The sensors sets 1A and 2A include at least some of the sensors 1-7 of FIG.", "7.The harvest actuator sets 1A and 2A includes one or more actuators associated with at least one of a combine and any crop harvesting machine.", "The auxiliary resources 1A and 2A includes any other agricultural resource that may be associated with the harvest apparatus set such as one or more of a grain cart, a harvest crop wagon, a fertilizer transporter, a water transporter, etc.", "The user device 1-1A traverses portions of a drive path 1 within the geographic region 1 in accordance with a first agricultural prescription and the user device 1-2A traverses portions of a drive path 2 within the geographic region 1 in accordance with one or more of a second agricultural prescription and the first agricultural prescription.", "The computing system is operable to improve accuracy of crop yield data.", "In an example of operation of the improving of the accuracy of the crop yield data, the application processing module 34 of at least one of the application unit 16 and any user device obtains data records 1 for harvesting of a portion of the geographic region 1 by the harvest apparatus set 1.The harvesting may be carried out in accordance with a prescription based on guidance 72 from a primary user device (e.g., the user device 14).", "The data records 1 includes sensor data 1 obtained by at least one of receiving the sensor data 1 from the harvest apparatus set 1 (e.g., via wireless communication signals 42 over the wireless location network 1 and the network 24) and retrieving the sensor data 1 from the memory of the storage unit.", "The sensor data 1 includes one or more of a fuel flow rate, a combine revolutions per minute (RPM), a combine torque level, a combine velocity, a combine pitch, a combine yaw, a combine heading bearing, a combine roll, a combine altitude, and a terrain gradient.", "Having obtained the data records 1 for the harvesting, the application unit 16 obtains yield data that corresponds to the data records.", "The obtaining includes at least one of determining and retrieving.", "The yield data includes at least one of an estimated crop yield level and an actual crop yield level.", "For example, the application unit 16 recovers the actual crop yield data from the storage unit subsequent to the storage unit receiving the crop yield data.", "Having obtained the yield data, the application unit 16 determines correlation data 1 that associates the data records 1 to the yield data for the portion of the geographic region.", "For example, the application unit 16 identifies an amount of crop yielded for levels of consumed fuel, applied torque, and average velocity to produce the correlation data 1.Having produced the correlation data 1, the application unit 16 sends, via the network 24 and the wireless communication network 1, the correlation data 1 to the harvest apparatus set 2, where the harvest apparatus set 2 generates harvest information 2 based on the sensor data of the harvest apparatus set 2 and the correlation data 1.The harvest information 2 includes at least one of an estimated crop flow rate, a corrected crop flow rate, an estimated crop yield level (e.g., bushels per acre), and a corrected crop yield level.", "For example, the user device 1-2A (e.g., or user device 1-2B, or user device 1-2C) applies a correction function to the sensor data 2 in accordance with the correlation data 1 to produce the harvest information 2.Alternatively, or in addition to, the application unit 16 sends the correlation data 1 to the harvest apparatus set 1 such that the harvest apparatus set 1 applies the correction function to subsequently obtained sensor data 1 in accordance with the correlation data 1 to produce harvest information 1.Having sent the correlation data 1 to the harvest apparatus set 2, the application unit 16 obtains the harvest information 2.The obtaining includes at least one of receiving the harvest information 2 directly from the harvest apparatus set 2 (e.g., via wireless communication signals 42 over the wireless communication network 1 and the network 24) and extracting the harvest information 2 from the data records 2 retrieved from the storage unit 36.FIG.", "26B is a flowchart illustrating an example of improving accuracy of crop yield data.", "The method begins or continues at step 590 where a processing module (e.g., an application processing module of at least one of an application unit and a user device), for an agricultural prescription of a geographic region, obtains data records associated with harvesting of a portion of a geographic region by a first harvest apparatus set.", "The obtaining includes receiving the data records directly from the first harvest apparatus set and retrieving the data records from a storage unit.", "The data records include sensor data associated with the harvesting including one or more of a fuel flow rate, an RPM, a torque level, a velocity level, a pitch level, a yaw level, a bearing, a roll level, an altitude, a terrain gradient and historical summaries of previously collected data records associated with the portion of the geographic region.", "The method continues at step 592 where the processing module obtains yield data that corresponds to the data records.", "The yield data includes estimated and/or actual yield statistics with regards to a rate of crops harvested as a function of area and/or linear distance (e.g., bushels per acre, bushels per linear harvest distance).", "The obtaining includes at least one of determining, receiving, and retrieving from the storage unit.", "The method continues at step 594 where the processing module determines correlation data that correlates the data records to the yield data for the portion of the geographic region.", "For example, the processing module solves for a linear equation of factors of the data records that results in an acceptable estimation of the yield data, extracts coefficients of the linear equations, and generates the correlation data to include a model of the linear equation that includes the extracted coefficients.", "The method continues at step 596 where the processing module sends the correlation data to at least a second harvest apparatus set, where the second harvest apparatus set generates harvest information and/or yield data based on sensor data of the second harvest apparatus set and the correlation data.", "For example, the second harvest apparatus set utilizes the linear equation and extracted coefficients on the sensor data of the second harvest apparatus set to produce the yield information.", "The method continues at step 598 where the processing module receives the harvest information from the second harvest apparatus set.", "For example, the second harvest apparatus set sends the harvest information to one or more of an application unit, a storage unit, a primary user device, and one or more other of the harvest apparatus sets.", "The second harvest apparatus set may further display the yield data to an operator of the second harvest apparatus set to facilitate optimization of settings of one or more elements of the second harvest apparatus set to provide further yield efficiencies.", "FIG.", "27A is a schematic block diagram of another embodiment of a computing system that includes the geographic region 1 of FIG.", "1, the wireless communication network 1 of FIG.", "1, the network 24 of FIG.", "1, the user device 14 of FIG.", "5, the application unit 16 of FIG.", "5, and the storage unit 36 of FIG.", "5.The geographic region 1 includes harvest apparatus sets 1-2 and user devices 1-1C and 1-2C of FIG.", "1.Each harvest apparatus set includes the user device 1-1A or 1-2A of FIG.", "1, the sensors set 1A or 2A of FIG.", "24A, the harvest actuator set 1A or 2A of FIG.", "24A, and the auxiliary resource 1A or 2A of FIG.", "24A.", "The geographic region 1 may further include a user device 1-1B and/or 1-2B to provide one or more of communication, processing, and discovery of other like proximal user devices, where the communication includes transfer of information between the user device 1-1C and the user device 1-1A over the user device 1-2C and the user device 1-2A in a similar fashion as user device 2-1B provides processing and communication between user devices 2-1C and 2-1A of FIG.", "12A.", "The user devices 1-1A and 1-2A includes the application processing module 34 of FIG.", "4 and the wireless communication modem 1 of FIG.", "4.The sensors sets 1A and 2A include at least some of the sensors 1-7 of FIG.", "7.The harvest actuator sets 1A and 2A includes one or more actuators associated with at least one of a combine and any crop harvesting machine.", "The auxiliary resources 1A and 2A includes any other agricultural resource that may be associated with the harvest apparatus set such as one or more of a grain cart, a harvest crop wagon, a fertilizer transporter, a water transporter, etc.", "The user device 1-1A traverses a drive path 1_1 and a drive path 1_2 within the geographic region 1 in accordance with a first agricultural prescription, where the drive paths 1_1 and 1_2 are substantially adjacent paths (e.g., in the same or opposite directions).", "The user device 1-2A traverses portions of a drive path 2 within the geographic region 1 in accordance with one or more of a second agricultural prescription and the first agricultural prescription.", "The computing system is operable to improve accuracy of crop yield data.", "In an example of operation of the improving of the accuracy of the crop yield data, the application processing module 34 of at least one of the application unit 16 and any user device obtains data records for two or more traversals of harvesting of a portion of the geographic region 1 by the harvest apparatus set 1.For example, the application unit retrieves data records 1 from the storage unit 36, where the data records 1 includes sensor data 1_1 associated with the drive path 1_1 and sensor data 1_2 associated with the drive path 1_2, received via wireless communication signals 42 over the wireless location network 1 and the network 24 by the storage unit 36.The harvesting may be carried out in accordance with the first prescription based on guidance 72 from the user device 14 (e.g., a primary user device).", "The data records 1_1 and 1_2 includes sensor data produced by the harvest apparatus set.", "The sensor data includes one or more of a fuel flow rate, a combine revolutions per minute (RPM), a combine torque level, a combine velocity, a combine pitch, a combine yaw, a combine bearing, a combine roll, a combine altitude, and a terrain gradient.", "Having obtained the data records 1 for the two or more traversals of the harvesting, the application unit 16 obtains yield data that corresponds to the data records 1.The obtaining includes at least one of determining and retrieving.", "The yield data includes at least one of an estimated crop yield level and an actual crop yield level.", "For example, the application unit 16 recovers the actual crop yield data from the storage unit subsequent to the storage unit receiving the crop yield data.", "Having obtained the yield data, the application unit 16 determines correlation data 1 that associates the data records 1 for the two or more traversals, with regards to terrain changes, to the yield data for the portion of the geographic region.", "For example, the application unit 16 identifies an amount of crop yielded for a range of a terrain gradient for adjacent drive paths, levels of consumed fuel, applied torque, and average velocity to produce the correlation data 1.Having produced the correlation data 1, the application unit 16 sends, via the network 24 and the wireless communication network 1 via further wireless communication signals 42, the correlation data 1 to the harvest apparatus set 2, where the harvest apparatus set 2 generates harvest information 2 based on sensor data, including a terrain gradient, of the harvest apparatus set 2 and the correlation data 1.The harvest information 2 includes at least one of an estimated crop flow rate, a corrected crop flow rate, an estimated crop yield level (e.g., bushels per acre), and a corrected crop yield level.", "For example, the user device 1-2A (e.g., or user device 1-2B, or user device 1-2C) applies a correction function to sensor data 2 in accordance with the correlation data 1 to produce the harvest information 2.Alternatively, or in addition to, the application unit 16 sends the correlation data 1 to the harvest apparatus set 1 such that the harvest apparatus set 1 applies the correction function to subsequently obtained sensor data 1_x in accordance with the correlation data 1 to produce harvest information 1.Having sent the correlation data 1 to the harvest apparatus set 2, the application unit 16 obtains the harvest information 2.The obtaining includes at least one of receiving the harvest information 2 directly from the harvest apparatus set 2 (e.g., via the wireless communication network 1 and the network 24) and extracting the harvest information 2 from the data records 2 retrieved from the storage unit 36.FIG.", "27B is a flowchart illustrating another example of improving accuracy of crop yield data, which include similar steps to FIG.", "26B.", "The method begins or continues at step 610 where a processing module (e.g., an application processing module of at least one of an application unit and a user device), for an agricultural prescription of a geographic region, obtains data records associated with two or more traversals of harvesting a portion of a geographic region by a first harvest apparatus set, where the portion is associated with a terrain gradient greater than a terrain gradient threshold level.", "The obtaining includes at least one of receiving the data records directly from the first harvest apparatus set and retrieving the data records from a storage unit.", "The method continues at step 612 where the processing module obtains yield data that corresponds to the data records for each of the two or more traversals.", "The obtaining includes at least one of determining the yield data and retrieving the yield data from the storage unit.", "The yield data includes one or more of estimated and actual yield statistics (e.g., actual bushels per acre).", "The method continues at step 614 where the processing module determines correlation data that correlates the data records for each of the two or more traversals to the yield data for the portion of the geographic region.", "For example, the processing module solves for a linear equation of factors of the data records that results in an acceptable estimation of the yield data, extracts coefficients of the linear equations for all the traversals, and generates the correlation data to include a model of the linear equation that includes the extracted coefficients.", "The method continues with the steps 596-598 of FIG.", "26B where the processing module sends the correlation data to at least a second harvest apparatus set, where the second harvest apparatus set generates the harvest information and/or yield data based on sensor data of the second harvest apparatus set and the correlation data, and the processing module receives the harvest information from the second harvest apparatus set.", "FIG.", "28A is a schematic block diagram of another embodiment of a computing system that includes the geographic region 1 of FIG.", "1, the wireless communication network 1 of FIG.", "1, the network 24 of FIG.", "1, the user device 14 of FIG.", "5, the application unit 16 of FIG.", "5, and the storage unit 36 of FIG.", "5.The geographic region 1 includes a planting apparatus set 620, a harvesting apparatus set 622, a transport apparatus set 624, and user devices 1-1C, 1-2C, and 1-3C of FIG.", "1.The planting apparatus set 620 includes the user device 1-1A of FIG.", "1, the sensors set 1A of FIG.", "24A, a planting actuator set 1A, and the auxiliary resource 1A of FIG.", "24A.", "The planting actuator set 1A includes any apparatus to plant seeds.", "For instance, the planting actuator set 1A includes a planter and the auxiliary resource 1A includes a seed bin.", "The harvesting apparatus set 622 includes the user device 1-2A of FIG.", "1, the sensors set 2A of FIG.", "24A, the harvest actuator set 2A of FIG.", "24A, and the auxiliary resource 2A of FIG.", "24A.", "For instance, the harvest actuator set 2A includes a combine and the auxiliary resource 2A includes a crop cart.", "The transport apparatus set 624 includes the user device 1-3A of FIG.", "1, a sensors set 3A associated with the user device 1-3A, a transport actuator set 2A, and an auxiliary resource 3A.", "For instance, the user device 1-3A includes a truck, the sensors set 3A includes sensors associated with the truck, the transport actuator set 3A includes actuators for moving and transporting harvested crops (e.g., others, chute gates, liftgates, etc.", "), and the auxiliary resource 3A includes a shipping container for harvested crops.", "Alternatively, or in addition to, two or more transport apparatus sets 624 may be utilized to transport the harvested crops.", "A common auxiliary resource may be utilized when the two or more transport apparatus sets 624 are utilized.", "For example, the auxiliary resource 3A may be disassociated with a first transport apparatus set 624 and associated with a second transport apparatus set 624 in the course of transporting the harvested crops.", "For instance, a trailer containing harvested crops is disconnected from a first tractor (e.g., user device 1-3A1) along a drive path 3 and is connected to a second tractor (e.g., user device 1-3A2) along the drive path 3 as the harvested crops are transported.", "The geographic region 1 may further include a user device 1-1B, 1-2B, and/or 1-3B to provide one or more of communication, processing, and discovery of other like proximal user devices, where the communication includes transfer of information between the user devices 1-1C, 1-2C, and 1-3C and the user devices 1-1A, 1-2A, and 1-3A in a similar fashion as user device 2-1B provides processing and communication between user devices 2-1C and 2-1A of FIG.", "12A.", "The user devices 1-1A, 1-2A, and 1-3A includes the application processing module 34 of FIG.", "4 and the wireless communication modem 1 of FIG.", "4.The sensors sets 1A, 2A, and 3A include at least some of the sensors 1-7 of FIG.", "7.The user device 1-1A traverses a drive path 1 within the geographic region 1 in accordance with a first agricultural prescription 1, the user device 1-2A traverses a drive path 2 within the geographic region 1 in accordance with a second agricultural prescription 2, and the user device 1-3A traverses the drive path 3 which may be partially in accordance with a third agricultural prescription 3.The computing system is operable to track harvested crops utilizing a chain of custody approach.", "In an example of operation of the tracking of the harvested crops, the application unit 16 obtains data records 1 associated with execution of the agricultural prescription 1 by the planting apparatus set 620.The data records 1 includes data 1.The data 1 includes static and dynamic data associated with one or more of the user device 1-1A, the sensors set 1A, the planting actuator set 1A, and the auxiliary resource 1A.", "The static and dynamic data includes one or more of location information, timestamp information, sensor data, auxiliary data, and identifiers.", "The obtaining includes at least one of directly receiving, via wireless communication signals 42 over the wireless communication network 1 and the network, the data 1 from the planting apparatus set 620 and retrieving the data records 1 from the storage unit 36.Having obtained the data records 1, the application unit 16 identifies a planting location of a lot (e.g., an identified portion of a larger production) and a seed hybrid associated with the planting apparatus set 620.For example, the application unit 16 identifies the auxiliary resource affiliated with the planting apparatus set 620, where the identified auxiliary resource has been previously associated with the lot of the seed hybrid.", "For instance, the application unit 16 interprets historical location information associated with the seed bin.", "Having identified the lot and seed hybrid associated with the planting location, the application unit 16 obtains data records 2 associated with execution of the agricultural prescription 2 by the harvesting apparatus set 622.The data records 2 includes data 2.The data 2 includes static and dynamic data associated with one or more of the user device 1-2A, the sensors set 2A, the harvest actuator set 2A, and the auxiliary resource 2A.", "The obtaining includes at least one of directly receiving, via further wireless communication signals 42 over the wireless communication network 1 and the network, the data 2 from the harvesting apparatus set 622 and retrieving the data records 2 from the storage unit 36.For a harvested crop associated with the planting location, the application unit 16 identifies the lot and seed hybrid.", "For example, the application unit 16 performs a lookup of the lot and seed hybrid based on location information of the data records 2.Having identified the lot and the seed hybrid, the application unit 16 identifies the auxiliary resource 2A of the harvesting apparatus set 622 that is associated with the harvested crops.", "For example, the application unit 16 extracts an identifier of the auxiliary resource 2A, that holds the harvested crops, from the data records 2.Having identified the auxiliary resource 2A, the application unit 16 identifies subsequent auxiliary resources associated with transport of the harvested crop in accordance with the agricultural prescription 3 and/or guidance 72 from user device 14.For example, the application unit 16 obtains data records 3, where the data records 3 includes data 3, interprets data records 3 and data records 2 to detect one or more of substantially similar location information, loading and/or unloading and transfer of crops, and proximal location by discovery of short range wireless communication signals (e.g., between two or more of the user device 1-2B and user device 1-3B).", "For a final auxiliary resource 3A of the transport of the harvested crops, the application unit identifies (e.g., look up of records from the above identification steps) the lot and seed hybrid as the harvested crops arrive at a final destination associated with the transporting.", "FIG.", "28B is a flowchart illustrating an example of chain of custody crop tracking.", "The method begins or continues at step 630 where a processing module (e.g., an application processing module of at least one of an application unit and a user device), obtains first data records associated with execution of a first agricultural prescription by a planting apparatus set.", "The obtaining includes at least one of receiving the first data records directly from the planting apparatus set and retrieving the first data records from a storage unit.", "The method continues at step 632 where the processing module identifies a planting location of a lot and a seed hybrid associated with the planting apparatus set.", "For example, the processing module determines an identifier of an auxiliary resource associated with the first data records by utilizing short range wireless discovery, identifies the lot and seed hybrid associated with the identified auxiliary resource (e.g., a lookup), and utilizes location information of the auxiliary resource (e.g., from the first data records) to produce the planting location associated with the identified lot and seed hybrid.", "The processing module may store a record that includes one or more of the planting location, the identified lot, the identified seed hybrid, and the identified auxiliary resource.", "The method continues at step 634 where the processing module obtains second data records associated with execution of a second prescription by a harvesting apparatus set.", "The obtaining includes at least one of receiving the second data records directly from the harvesting apparatus set and retrieving the second data records from the storage unit.", "The second data records includes one or more of identifiers of elements of the harvesting apparatus set and location information associated with harvesting crops to produce location information of harvested crops.", "For a harvested crop associated with the planting location, the method continues at step 636 where the processing module identifies the lot and the seed hybrid based on the second data records.", "For example, the processing module identifies a location information of the second data records that is substantially the same as the planting location, performs a lookup of the lot and seed hybrid identifiers corresponding to the planting location, and associates harvested crops with the lot and seed hybrid identifiers.", "The associating may include storing a new record and/or updating the stored record to include the identified location information of the harvested crops, planting location, the identified lot, and the identified seed hybrid.", "The method continues at step 638 where the processing module identifies an auxiliary resource of the harvesting apparatus set that is associated with the harvested crop.", "For example, the processing module interprets the second data records to extract an identifier of the auxiliary resource associated with temporary storage of the harvested crops, where the location information (e.g., GPS coordinates) is compared or short range wireless discovery is interpreted to identify a proximal auxiliary resource as the auxiliary resource.", "The method continues at step 640 where the processing module identifies subsequent auxiliary resources associated with transport of the harvested crop in accordance with execution of a third agricultural prescription.", "For example, the processing module interprets third data records from a transport apparatus set to extract an identifier of one or more subsequent auxiliary resources associated with transport of the harvested crop, where the location information is compared or short range wireless discovery is interpreted to identify further proximal auxiliary resources as the identified subsequent auxiliary resources.", "The method continues at step 642 where the processing module identifies the lot and the seed hybrid associated with a final step of harvested crop transport.", "For example, the processing module interprets further third data records to extract further identifiers of yet another auxiliary resource associated with the final step of transporting the harvested crop and performs a record lookup to identify the associated lot and seed hybrid, where location information is compared or short range wireless discovery is interpreted to identify and even further proximal auxiliary resource as the identified other auxiliary resource.", "As may be used herein, the terms “substantially” and “approximately” provides an industry-accepted tolerance for its corresponding term and/or relativity between items.", "Such an industry-accepted tolerance ranges from less than one percent to fifty percent and corresponds to, but is not limited to, component values, integrated circuit process variations, temperature variations, rise and fall times, and/or thermal noise.", "Such relativity between items ranges from a difference of a few percent to magnitude differences.", "As may also be used herein, the term(s) “operably coupled to”, “coupled to”, and/or “coupling” includes direct coupling between items and/or indirect coupling between items via an intervening item (e.g., an item includes, but is not limited to, a component, an element, a circuit, and/or a module) where, for indirect coupling, the intervening item does not modify the information of a signal but may adjust its current level, voltage level, and/or power level.", "As may further be used herein, inferred coupling (i.e., where one element is coupled to another element by inference) includes direct and indirect coupling between two items in the same manner as “coupled to”.", "As may even further be used herein, the term “operable to” or “operably coupled to” indicates that an item includes one or more of power connections, input(s), output(s), etc., to perform, when activated, one or more its corresponding functions and may further include inferred coupling to one or more other items.", "As may still further be used herein, the term “associated with”, includes direct and/or indirect coupling of separate items and/or one item being embedded within another item.", "As may be used herein, the term “compares favorably”, indicates that a comparison between two or more items, signals, etc., provides a desired relationship.", "For example, when the desired relationship is that signal 1 has a greater magnitude than signal 2, a favorable comparison may be achieved when the magnitude of signal 1 is greater than that of signal 2 or when the magnitude of signal 2 is less than that of signal 1.As may also be used herein, the terms “processing module”, “processing circuit”, and/or “processing unit” may be a single processing device or a plurality of processing devices.", "Such a processing device may be a microprocessor, micro-controller, digital signal processor, microcomputer, central processing unit, field programmable gate array, programmable logic device, state machine, logic circuitry, analog circuitry, digital circuitry, and/or any device that manipulates signals (analog and/or digital) based on hard coding of the circuitry and/or operational instructions.", "The processing module, module, processing circuit, and/or processing unit may be, or further include, memory and/or an integrated memory element, which may be a single memory device, a plurality of memory devices, and/or embedded circuitry of another processing module, module, processing circuit, and/or processing unit.", "Such a memory device may be a read-only memory, random access memory, volatile memory, non-volatile memory, static memory, dynamic memory, flash memory, cache memory, and/or any device that stores digital information.", "Note that if the processing module, module, processing circuit, and/or processing unit includes more than one processing device, the processing devices may be centrally located (e.g., directly coupled together via a wired and/or wireless bus structure) or may be distributedly located (e.g., cloud computing via indirect coupling via a local area network and/or a wide area network).", "Further note that if the processing module, module, processing circuit, and/or processing unit implements one or more of its functions via a state machine, analog circuitry, digital circuitry, and/or logic circuitry, the memory and/or memory element storing the corresponding operational instructions may be embedded within, or external to, the circuitry comprising the state machine, analog circuitry, digital circuitry, and/or logic circuitry.", "Still further note that, the memory element may store, and the processing module, module, processing circuit, and/or processing unit executes, hard coded and/or operational instructions corresponding to at least some of the steps and/or functions illustrated in one or more of the Figures.", "Such a memory device or memory element can be included in an article of manufacture.", "The present invention has been described above with the aid of method steps illustrating the performance of specified functions and relationships thereof.", "The boundaries and sequence of these functional building blocks and method steps have been arbitrarily defined herein for convenience of description.", "Alternate boundaries and sequences can be defined so long as the specified functions and relationships are appropriately performed.", "Any such alternate boundaries or sequences are thus within the scope and spirit of the claimed invention.", "Further, the boundaries of these functional building blocks have been arbitrarily defined for convenience of description.", "Alternate boundaries could be defined as long as the certain significant functions are appropriately performed.", "Similarly, flow diagram blocks may also have been arbitrarily defined herein to illustrate certain significant functionality.", "To the extent used, the flow diagram block boundaries and sequence could have been defined otherwise and still perform the certain significant functionality.", "Such alternate definitions of both functional building blocks and flow diagram blocks and sequences are thus within the scope and spirit of the claimed invention.", "One of average skill in the art will also recognize that the functional building blocks, and other illustrative blocks, modules and components herein, can be implemented as illustrated or by discrete components, application specific integrated circuits, processors executing appropriate software and the like or any combination thereof.", "The present invention may have also been described, at least in part, in terms of one or more embodiments.", "An embodiment of the present invention is used herein to illustrate the present invention, an aspect thereof, a feature thereof, a concept thereof, and/or an example thereof.", "A physical embodiment of an apparatus, an article of manufacture, a machine, and/or of a process that embodies the present invention may include one or more of the aspects, features, concepts, examples, etc.", "described with reference to one or more of the embodiments discussed herein.", "Further, from figure to figure, the embodiments may incorporate the same or similarly named functions, steps, modules, etc.", "that may use the same or different reference numbers and, as such, the functions, steps, modules, etc.", "may be the same or similar functions, steps, modules, etc.", "or different ones.", "While the transistors in the above described figure(s) is/are shown as field effect transistors (FETs), as one of ordinary skill in the art will appreciate, the transistors may be implemented using any type of transistor structure including, but not limited to, bipolar, metal oxide semiconductor field effect transistors (MOSFET), N-well transistors, P-well transistors, enhancement mode, depletion mode, and zero voltage threshold (VT) transistors.", "Unless specifically stated to the contra, signals to, from, and/or between elements in a figure of any of the figures presented herein may be analog or digital, continuous time or discrete time, and single-ended or differential.", "For instance, if a signal path is shown as a single-ended path, it also represents a differential signal path.", "Similarly, if a signal path is shown as a differential path, it also represents a single-ended signal path.", "While one or more particular architectures are described herein, other architectures can likewise be implemented that use one or more data buses not expressly shown, direct connectivity between elements, and/or indirect coupling between other elements as recognized by one of average skill in the art.", "The term “module” is used in the description of the various embodiments of the present invention.", "A module includes a processing module, a functional block, hardware, and/or software stored on memory for performing one or more functions as may be described herein.", "Note that, if the module is implemented via hardware, the hardware may operate independently and/or in conjunction software and/or firmware.", "As used herein, a module may contain one or more sub-modules, each of which may be one or more modules.", "While particular combinations of various functions and features of the present invention have been expressly described herein, other combinations of these features and functions are likewise possible.", "The present invention is not limited by the particular examples disclosed herein and expressly incorporates these other combinations." ] ]
Patent_15875993
[ [ "ASYMMETRIC SESSION CREDENTIALS", "Techniques for using short-term credentials using asymmetric session keys are described herein.", "A request for a short-term credential is received that is digitally signed with a different credential.", "In response to the request, short-term credential data is generated and populated with a public session key corresponding to a private session key.", "The short-term credential data is then encrypted with a session encryption key to produce the short-term credential token, which can then be used by the requester as a short-term credential for subsequent requests." ], [ "1.A computer-implemented method, comprising: generating, based at least on an encryption key and as a result of a request to establish a session, credential data usable to authenticate messages within the session; and providing, in response to the request, the credential data to at least: cause extraction of the encryption key from the credential data; and cause authentication of the messages in the session using the encryption key.", "2.The computer-implemented method of claim 1, wherein the credential data is valid for a predetermined amount of time.", "3.The computer-implemented method of claim 1, further comprising: generating additional requests, while the credential data is valid, to authenticate additional messages.", "4.The computer-implemented method of claim 1, further comprising: in response to determining that the credential data has been comprised, invalidating the credential data; and sending a request for new credential data.", "5.A system, comprising: memory to store instructions that, if executed by one or more processors of the system, cause the system to: generate, based at least on an encryption key and as a result of a request to establish a session, credential data usable to authenticate messages within the session; and provide, in response to the request, the credential data to at least: cause extraction of the encryption key from the credential data; and cause authentication of the messages in the session using the encryption key.", "6.The system of claim 5, wherein the credential data is valid for a predetermined amount of time.", "7.The system of claim 5, wherein the instructions that, if executed by one or more processors of the system, further cause the system to: generate additional requests, while the credential data is valid, to authenticate additional messages.", "8.The system of claim 5, wherein the instructions that, if executed by one or more processors of the system, further cause the system to: in response to determining that the credential data has been comprised, invalidating the credential data; and send a request for new credential data.", "9.The system of claim 5, wherein the request to establish the session is digitally signed using a long-term key associated with an account of a requestor.", "10.The system of claim 9, wherein the instructions that, if executed by one or more processors of the system, further cause the system to: verify, at a security service, a digital signature associated with the request to establish the session.", "11.The system of claim 10, wherein in response to the security service verifying the request, the security service generates the credential data.", "12.The system of claim 11, wherein in response to the security service generating the credential data, the security service encrypts the generated credential data using a session encryption key.", "13.A non-transitory computer-readable storage medium having stored thereon executable instructions that, as a result of being executed by one or more processors of a computer system, cause the computer system to at least: generate, based at least on an encryption key and as a result of a request to establish a session, credential data usable to authenticate messages within the session; and provide, in response to the request, the credential data to at least: cause extraction of the encryption key from the credential data; and cause authentication of the messages in the session using the encryption key.", "14.The non-transitory computer-readable storage medium of claim 13, wherein the credential data is valid for a predetermined amount of time.", "15.The non-transitory computer-readable storage medium of claim 13, wherein the instructions further comprise instructions that, as a result of being executed by the one or more processors, cause the computer system to: generate additional requests, while the credential data is valid, to authenticate additional messages.", "16.The non-transitory computer-readable storage medium of claim 13, wherein the instructions further comprise instructions that, as a result of being executed by the one or more processors, cause the computer system to: in response to determining that the credential data has been comprised, invalidating the credential data; and send a request for new credential data.", "17.The non-transitory computer-readable storage medium of claim 13, wherein the request to establish the session is digitally signed using a long-term key associated with an account of a requestor.", "18.The non-transitory computer-readable storage medium of claim 17, wherein the instructions that, if executed by one or more processors of the system, further cause the system to: verify, at a security service, a digital signature associated with the request to establish the session.", "19.The non-transitory computer-readable storage medium of claim 18, wherein in response to the security service verifying the request, the security service generates the credential data.", "20.The non-transitory computer-readable storage medium of claim 19, wherein in response to the security service generating the credential data, the security service encrypts the generated credential data using a session encryption key." ], [ "<SOH> BACKGROUND <EOH>Modern computer systems typically have different services and resources that can be accessed by users of the computer system.", "When users request access to the services and resources, such requests are generally verified before access is granted so that a user does not gain access to services and resources not granted by the set of permissions associated with that user account.", "One system typically used for providing secure access to services and resources is based on creating short-term session credentials that are associated with a user.", "Once a session is established, a user can use the session credentials associated with the session to issue multiple requests over the life of that session.", "Typically, session credentials are encrypted and include a secret key that is used to sign each of the multiple requests over the life of the session.", "A drawback of such sessions and the associated session credentials is that any service that can decrypt the session credentials can have access to the secret key.", "Since decrypting the session credentials is typically required to verify a request, when the secret key is a symmetric key, the secret key can be used by services to improperly sign additional requests.", "For example, a service can receive a request and decrypt the session credentials associated with the request to extract the secret key for the purposes of verifying the request.", "However, the service may also use the extracted secret key to generate requests to other services, even though such requests may not necessarily originate from the owner of the session." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>Various techniques will be described with reference to the drawings, in which: FIG.", "1 illustrates an environment where session credentials are generated; FIG.", "2 illustrates an environment where requests are validated using session credentials; FIG.", "3 illustrates a diagram showing encryption operations associated with using session credentials; FIG.", "4 illustrates a diagram showing decryption operations associated with using session credentials; FIG.", "5 illustrates a process for validating requests using session credentials; FIG.", "6 illustrates a process for using a session token to generate resource requests using session credentials; FIG.", "7 illustrates an environment where session credentials are generated with asymmetric keys; FIG.", "8 illustrates an environment where requests are validated using session credentials with asymmetric keys; FIG.", "9 illustrates a diagram showing encryption operations associated with using session credentials with asymmetric keys; FIG.", "10 illustrates a process for validating requests using session credentials with asymmetric keys; FIG.", "11 illustrates an environment where a session associated with a region is retrieved using session credentials; FIG.", "12 illustrates an environment where a retrieved session is used across regions using session credentials; FIG.", "13 illustrates an environment where session data is used across regions to generate a cross-region session using session credentials; FIG.", "14 illustrates a process for generating a cross-region session using session credentials; FIG.", "15 illustrates a process for extracting session data from a cross-region session using session credentials; FIG.", "16 illustrates an environment where a cross-region session is validated using session credentials; FIG.", "17 illustrates an environment where a service intercepts a session using session credentials; FIG.", "18 illustrates an environment where an account key and a global key are used to generate a session key for use in generating session credentials; FIG.", "19 illustrates an environment where an account key is distributed to different regions for use in isolating regions using session credentials; FIG.", "20 illustrates a process for distributing an account key to different regions for use in isolating regions using session credentials; FIG.", "21 illustrates an environment where global session keys are combined with account keys to generate session credentials; FIG.", "22 illustrates an environment where global session keys are combined with account keys to generate session credentials; FIG.", "23 illustrates an environment where global session keys are maintained for use in generating session credentials; FIG.", "24 illustrates an environment where sessions are expired using session credentials; FIG.", "25 illustrates a process for rotating session credentials; FIG.", "26 illustrates an environment where a plurality of session keys can be invalidated using session credentials; FIG.", "27 illustrates an environment where a plurality of invalidated session keys can be regenerated using session credentials; FIG.", "28 illustrates a process for invalidating and regenerating a plurality of session keys using session credentials; FIG.", "29 illustrates an environment where account keys are invalidated in association with session credentials; FIG.", "30 illustrates an environment where cross-region roles are assumed across regions using session credentials; FIG.", "31 illustrates an environment where policies associated with cross-region roles are applied using session credentials; FIG.", "32 illustrates an environment where a cross-region role is assumed using session credentials; FIG.", "33 illustrates an environment where a cross-region role is used to access resources across regions using session credentials; FIG.", "34 illustrates a process for using a cross-region role session token to generate resource requests using session credentials; and FIG.", "35 illustrates an environment in which various embodiments can be implemented.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "14/958,872, filed Dec. 3, 2015, entitled “ASYMMETRIC SESSION CREDENTIALS,” which incorporates by reference for all purposes the full disclosure of co-pending U.S. patent application Ser.", "No.", "14/958,887, filed Dec. 3, 2015, entitled “CROSS-REGION ROLES,” co-pending U.S. patent application Ser.", "No.", "14/958,888, filed Dec. 3, 2015, entitled “CROSS-REGION CACHE OF REGIONAL SESSIONS,” and co-pending U.S. patent application Ser.", "No.", "14/958,892, filed Dec. 3, 2015, entitled “PERSONALIZING GLOBAL SESSION IDENTIFIERS.” BACKGROUND Modern computer systems typically have different services and resources that can be accessed by users of the computer system.", "When users request access to the services and resources, such requests are generally verified before access is granted so that a user does not gain access to services and resources not granted by the set of permissions associated with that user account.", "One system typically used for providing secure access to services and resources is based on creating short-term session credentials that are associated with a user.", "Once a session is established, a user can use the session credentials associated with the session to issue multiple requests over the life of that session.", "Typically, session credentials are encrypted and include a secret key that is used to sign each of the multiple requests over the life of the session.", "A drawback of such sessions and the associated session credentials is that any service that can decrypt the session credentials can have access to the secret key.", "Since decrypting the session credentials is typically required to verify a request, when the secret key is a symmetric key, the secret key can be used by services to improperly sign additional requests.", "For example, a service can receive a request and decrypt the session credentials associated with the request to extract the secret key for the purposes of verifying the request.", "However, the service may also use the extracted secret key to generate requests to other services, even though such requests may not necessarily originate from the owner of the session.", "BRIEF DESCRIPTION OF THE DRAWINGS Various techniques will be described with reference to the drawings, in which: FIG.", "1 illustrates an environment where session credentials are generated; FIG.", "2 illustrates an environment where requests are validated using session credentials; FIG.", "3 illustrates a diagram showing encryption operations associated with using session credentials; FIG.", "4 illustrates a diagram showing decryption operations associated with using session credentials; FIG.", "5 illustrates a process for validating requests using session credentials; FIG.", "6 illustrates a process for using a session token to generate resource requests using session credentials; FIG.", "7 illustrates an environment where session credentials are generated with asymmetric keys; FIG.", "8 illustrates an environment where requests are validated using session credentials with asymmetric keys; FIG.", "9 illustrates a diagram showing encryption operations associated with using session credentials with asymmetric keys; FIG.", "10 illustrates a process for validating requests using session credentials with asymmetric keys; FIG.", "11 illustrates an environment where a session associated with a region is retrieved using session credentials; FIG.", "12 illustrates an environment where a retrieved session is used across regions using session credentials; FIG.", "13 illustrates an environment where session data is used across regions to generate a cross-region session using session credentials; FIG.", "14 illustrates a process for generating a cross-region session using session credentials; FIG.", "15 illustrates a process for extracting session data from a cross-region session using session credentials; FIG.", "16 illustrates an environment where a cross-region session is validated using session credentials; FIG.", "17 illustrates an environment where a service intercepts a session using session credentials; FIG.", "18 illustrates an environment where an account key and a global key are used to generate a session key for use in generating session credentials; FIG.", "19 illustrates an environment where an account key is distributed to different regions for use in isolating regions using session credentials; FIG.", "20 illustrates a process for distributing an account key to different regions for use in isolating regions using session credentials; FIG.", "21 illustrates an environment where global session keys are combined with account keys to generate session credentials; FIG.", "22 illustrates an environment where global session keys are combined with account keys to generate session credentials; FIG.", "23 illustrates an environment where global session keys are maintained for use in generating session credentials; FIG.", "24 illustrates an environment where sessions are expired using session credentials; FIG.", "25 illustrates a process for rotating session credentials; FIG.", "26 illustrates an environment where a plurality of session keys can be invalidated using session credentials; FIG.", "27 illustrates an environment where a plurality of invalidated session keys can be regenerated using session credentials; FIG.", "28 illustrates a process for invalidating and regenerating a plurality of session keys using session credentials; FIG.", "29 illustrates an environment where account keys are invalidated in association with session credentials; FIG.", "30 illustrates an environment where cross-region roles are assumed across regions using session credentials; FIG.", "31 illustrates an environment where policies associated with cross-region roles are applied using session credentials; FIG.", "32 illustrates an environment where a cross-region role is assumed using session credentials; FIG.", "33 illustrates an environment where a cross-region role is used to access resources across regions using session credentials; FIG.", "34 illustrates a process for using a cross-region role session token to generate resource requests using session credentials; and FIG.", "35 illustrates an environment in which various embodiments can be implemented.", "DETAILED DESCRIPTION This disclosure relates to managing message authentication within a computing resource service provider environment using short-term credentials.", "The short-term credentials are generated based on long-term credentials and can be used within a computer system or across computer system boundaries.", "The short-term credentials can also be secured so that they may be used in untrusted environments without compromising either the short-term credentials or the underlying long-term credentials.", "The short-term credentials can also be partially based on other, short-term credentials so that, for example, they can be regularly expired and efficiently invalidated at an individual, account, regional, or global scale.", "The short term credentials can also be used to assign and validate short-term access to user roles so that a user can have access to resources in a region or location that the user may not generally have access to.", "A request from a customer of a computing resource service provider for access to computing resources of the computing resource service provider is typically signed or authenticated by a key and that key is used to verify the request prior to executing or fulfilling the request.", "One method of signing the request is to use a long-term secret key that is maintained as a shared secret between the customer and the computing resource service provider.", "In this method, the customer signs the request using the long-term secret key and sends the request and the signature to the computing resource service provider.", "The computing resource service provider then verifies the signature using the same secret key and, if the signature is verified, the computing resource service provider executes or fulfills the request by, for example, providing resources, executing applications, or performing operations associated with the request.", "One potential drawback of using long-term credentials to provide access is that, if the long-term credentials are compromised, they provide a mechanism for the detection of unauthorized access by an unauthorized agent.", "Another potential drawback of using such long-term credentials is that, if they are used for multiple transactions by a customer, the likelihood of their being compromised may increase.", "A third potential drawback of using such long-term credentials is that, in the interest of increasing their security, the cryptographic operations associated with such long-term credentials can become very computationally expensive if, for example, larger keys and/or more complicated key-generation algorithms are used.", "Using short-term credentials such as those provided by session credentials helps alleviate some of the potential drawbacks of using long-terms credentials as message authenticators.", "One example of how a customer may obtain short-term session credentials that may be used as message authenticators is the customer may first generate a request for a session, and sign the request with a long-term secret key such as, for example, an account key.", "The request may then be sent to a security service which verifies the request signature.", "If the verification is successful, the security service can then generate a set of session data (also referred to herein as “short-term credential data”) that includes a session key and encrypt the short-term credential data to produce a short-term credential such as a session credential (also referred to herein as a “session token”).", "The session token is encrypted with a session encryption key that is available only to the computing resource service provider and provided to the customer.", "The encryption of the session token prevents the customer from accessing the session data in the session token.", "The customer is also provided with a session key which is cryptographically related to the session key in the session data.", "When the customer sends a message using the session token, the session token is sent with the message and digitally signed with the session key sent to the customer.", "The computing resource service provider then extracts the session key from the session token using the secret encryption key and verifies the digital signature of the message using the extracted session key.", "If the digital signature is verified, the message is processed.", "Using short-term credentials provided by session tokens, the customer can sign messages and have them authenticated without compromising long-term credentials.", "The long-term credentials (e.g., a password, a private key, or a certificate) are used to generate the request for the session token and the session token is only valid for a determined period of time.", "One example of how a session can be used by a customer is, a customer can request the session token using the username and password of the customer (i.e., the long-term credential) and can also request that the session be active for a certain time period (e.g., 36 hours).", "During the 36-hour period, the customer can generate messages and requests for resources using the session token and signed by the session key.", "Each request can be verified by the computing resource service provider without compromising the long-term key so, for example, the customer could generate thousands or millions of messages during the 36-hour period, and still have his or her username and password used only once.", "If, due to some circumstances, the short-term credentials in the session become compromised, the session token can be invalidated quickly and the customer can simply request a new session token.", "In an example of how session tokens can be used as message authenticators, the copy of the session key in the session data that is encrypted in the session token may be the same as the copy of the session key that is returned to the customer.", "This type of symmetric key session token maintains the security of short-term credentials with the session encryption key.", "While the customer has access to the session key that is sent from the computing resource service provider, the customer does not have access to the session key in the session token.", "The session key that the customer has access to can be used to digitally sign messages and requests for resources, but such messages and requests will not be verified if the session key in the session token does not match the digital signature.", "Thus, the session key cannot be used to digitally sign messages without the session token and the session token cannot be used without the signature of the session key.", "In another example of how session tokens can be used as message authenticators, the copy of the session key in the session data that is encrypted in the session token may one of a pair of session keys that form a public key encryption pair where the private key is maintained as a secret and the public key is used to verify the private key.", "In this type of asymmetric key session token, the session key in the session data is a public key and the session key that is provided to the customer is a corresponding private key.", "The security of the private key is maintained by the customer and the security of the public key is maintained within the session token with a session encryption key.", "As with a symmetric key session token, the session key that the customer has access to can be used to digitally sign messages and requests for resources, but such messages and requests will not be verified if the session key in the session token does not match the digital signature.", "In the case of asymmetric key session tokens, the public key in the session token can be used to verify the digital signature generated by the private key.", "In a first example of an asymmetric session token, the private key and the public key can be generated by the computing resource service provider and sent to the customer.", "In a second example of an asymmetric session token, the customer can maintain the private key for signing requests and provide the public key to the computing resource service provider for inclusion in the session token.", "Symmetric key session tokens and asymmetric key session tokens can be used to provide short-term credentials for users and/or customers in several different ways.", "In a first example, a customer or user in one zone (or region) of a computing resource service provider can obtain short-term credentials in that region, and can then use those region-specific short-term credentials to authenticate message and/or generate resource requests in other regions.", "Because the other regions may not have access to the session encryption keys of the original region, they may not normally be able to extract the session key from the session token to verify the digital signature.", "However, by sending a request to the original region to extract the session key from the session token, the message or request can be authenticated by the original region and then the short-term credentials used in the other regions.", "Similarly, customers can use session tokens across regions to authenticate access to resources in defined roles.", "For example, a user in a first region may create a set of permissions for access to resources in a second region such as, for example, the ability to access a particular database.", "This set of permissions defines a role for access to those resources and other users can assume that role to access the resources.", "Symmetric and asymmetric session tokens can be used across regions to access the role by providing an identifier associated with the role to the other users in other regions (i.e., regions different than where the resources are located).", "When the other users use the identifier associated with the role to assume the role, a symmetric or asymmetric session token can be generated, providing short-term credentials for the access.", "Such short-term credentials can also provide access to resources in untrusted regions such as, for example, external regions because the short-term credentials can all be both generated and verified in trusted regions, thereby protecting any sensitive information such as encryption keys from being accessed in the untrusted regions.", "Other aspects of symmetric and asymmetric session tokens can also be used to control access to customer credentials, to limit those credentials to certain regions, to personalize those credentials to customers, accounts, or roles, and/or to maintain those credentials, are also described in the present disclosure.", "For example, by encrypting a session token with a combination of encryption keys that are global, regional, and/or account-specific, only a customer associated with that account or in that region may be able to use that session token.", "Similarly, by encrypting a session token with a combination of encryption keys, the session tokens (and thus, the short-term credentials) may be quickly invalidated by discarding one of the encryption keys while keeping the others that may still be valid and/or usable.", "In the preceding and following description, various techniques are described.", "For purposes of explanation, specific configurations and details are set forth in order to provide a thorough understanding of possible ways of implementing the techniques.", "However, it will also be apparent that the techniques described below may be practiced in different configurations without the specific details.", "Furthermore, well-known features may be omitted or simplified to avoid obscuring the techniques being described.", "FIG.", "1 illustrates an example environment 100 where session credentials are generated in accordance with an embodiment.", "A customer 102 of a computing resource service provider 104 may generate a session request 108 (also referred to herein as a “request for a session”) from a security service that may be used as a short-term credential (also referred to as a “session token”) and which may be used to authenticate messages from the customer 102 to the computing resource service provider 104 and which may also be used to generate requests for resources from the computing resource service provider 104.In some embodiments, the computing resource service provider 104 may provide a distributed, virtualized, and/or datacenter environment within which one or more applications, processes, services, virtual machines, and/or other such computer system entities may be executed.", "In some embodiments, the customer 102 may be a person, or may be a process running on one or more remote computer systems, or may be some other computer system entity, user, or process.", "The commands to connect to the computer system instance may originate from an outside computer system and/or server, or may originate from an entity, user, or process on a remote network location, or may originate from an entity, user, or process within the computing resource service provider 104.The command to connect to the computing resource service provider 104 may be generated by a computer system client device associated with the customer 102, or may originate as a result of an automatic process, or may originate as a result of a combination of these and/or other such origin entities.", "In some embodiments, the command or commands to initiate the connection to the computing resource service provider 104 may be sent to the one or more services associated with and/or provided by the computing resource service provider 104, without the intervention of the customer 102.The commands to initiate the connection to the services may originate from the same origin as the commands to connect to the computing resource service provider 104, or may originate from another computer system and/or server, or may originate from a different entity, user, or process on the same or a different remote network location, or may originate from a different entity, user, or process within the computing resource service provider 104, or may originate from a different user of a computer system client device, or may originate as a result of a combination of these and/or other such same and/or different entities.", "The customer 102 may request connection to the computing resource service provider 104 via one or more connections and, in some embodiments, via one or more networks and/or entities associated therewith, such as servers connected to the network, either directly or indirectly.", "The computer system client device that may request access to the services may include any device that is capable of connecting with a computer system via a network, including at least servers, laptops, mobile devices such as smartphones or tablets, other smart devices such as smart watches, smart televisions, set-top boxes, video game consoles and other such network-enabled smart devices, distributed computer systems and components thereof, abstracted components such as guest computer systems or virtual machines, and/or other types of computing devices and/or components.", "The network may include, for example, a local network, an internal network, a public network such as the Internet, or other networks such as those listed or described below.", "The network may also operate in accordance with various protocols such as those listed or described below.", "The computing resource service provider 104 may provide access to one or more host machines, as well as provide access to one or more virtual machine (VM) instances as may be operating thereon.", "The services provided by the computing resource service provider 104 may also be implemented as and/or may utilize one or more VM instances as may be operating on the host machines.", "For example, the computing resource service provider 104 may provide a variety of services to the customer 102 and the customer 102 may communicate with the computing resource service provider 104 via an interface such as a web services interface or any other type of interface.", "While the example environment illustrated in FIG.", "1 shows a single connection or interface used to generate the session request 108 from the computing resource service provider 104, each of the services provided by the computing resource service provider 104 may have its own interface and, generally, subsets of the services may have corresponding interfaces in addition to or as an alternative to the single interface.", "The computing resource service provider 104 may provide various services to its users or customers (e.g., the customer 102).", "The services provided by the computing resource service provider 104 may include, but may not be limited to, virtual computer system services, block-level data storage services, cryptography services, on-demand data storage services, notification services, authentication services, policy management services, security services, or other services.", "Not all embodiments described may include all of these services, and additional services may be provided in addition to or as an alternative to the services explicitly described.", "As described above, each of the services may include one or more web service interfaces that enable the customer 102 to submit appropriately configured API requests to the various services through web service requests.", "In addition, each of the services may include one or more service interfaces that enable the services to access each other (e.g., to enable a virtual machine instance provided by the virtual computer system service to request credentials from a security service such as the security service 106).", "The security service 106 may be one of a plurality of services provided by the computing resource service provider 104 and may be configured to facilitate secure access to the services and/or other resources associated with the computing resource service provider 104.For example, the security service 106 may be configured to control access to resources of the computing resource service provider 104, may be configured to authenticate messages sent to the computing resource service provider 104, may be configured to verify credentials of customers such as the customer 102, may be configured to provide secure storage for credentials, may be configured to generate credentials, and may be configured to perform other security related operations associated with the computing resource service provider 104.For example, the security service 106 may generate cryptographic keys such as those described herein, may receive cryptographic keys from customers and/or other services, may maintain cryptographic keys as a service, and/or may use such cryptographic keys to validate requests and digital signatures of requests and messages.", "It should be noted that, as used herein, a “cryptographic key” may refer to a symmetric key, an asymmetric key, or some other authentication credential (e.g., a username and password or a certificate) and may be referred to simply as a “key.” In an embodiment, a security service maintains cryptographic keys as a secret within the security service by, for example, storing the key in a hardware security module (“HSM”).", "In another embodiment, a security service maintains cryptographic keys as a secret within the security service by being configured to not expose the key (e.g., because the security service is programmed to not provide the keys).", "In another embodiment, a security service maintains cryptographic keys as a secret within the security service by, for example, deleting the keys in the event of an intrusion.", "The session request 108 may be digitally signed 134 by the customer so that the security service 106 may validate the session request 110.In the example illustrated in FIG.", "1, the session request 108 is digitally signed 134 with a customer long-term key 132 associated with the customer 102.A customer long-term key 132 is a secure credential with a long-term period of validity (e.g., three months, six months, or more) that is uniquely associated with the customer 102.In another embodiment, the session request 108 is digitally signed 134 with a username and password of an account associated with the customer 102.In another embodiment, the session request is digitally signed 134 with a short-term credential such as those described herein (i.e., a session request 108 may be digitally signed 134 by a session token that may be specific to such requests).", "In another embodiment, the session request is digitally signed with a public key cryptography key pair that includes a public long-term key and a private long-term key.", "In another embodiment, the session request is digitally signed 134 by a certificate such as, for example, an X.509 certificate, or some other public or identify certificate.", "In another embodiment, the session request is digitally signed 134 by a combination of such cryptographic methods.", "As may be contemplated, the examples of cryptographic methods that may be used to digitally sign the session request described herein are illustrative examples and other such cryptographic methods that may be used to digitally sign the session request may be considered as within the scope of the present disclosure.", "When the security service 106 receives the session request 108 that is digitally signed 134 by, for example, the customer long-term key 132, the security service may first validate the request 110.Operations to validate the request 110 may include, but may not be limited to validating the identity of the customer 102, validating that the customer 102 is authorized to generate the session request 108, validating that the customer account used to generate the request is authorized to generate the session request 108, and/or validating that the request came from a computing device associated with the customer 102 that is authorized to generate the session request 108.In the example illustrated in FIG.", "1, the security service 106 validates the request by verifying that the session request 108 is digitally signed 134 by the customer long-term key 132 and that the customer long-term key 136 is being used by the customer 102 associated with the key.", "Although not illustrated in FIG.", "1, in the event that the session request 108 is not valid (i.e., that one or more of the operations to validate the request 110 yield a result indicating the request is not valid), an error may be generated and/or one or more notifications may be sent to the customer, an administrator, or some other such entity.", "If the session Request 108 is valid 112, the security service 106 may then process 114 the request.", "The security service 106 may first process 114 the request by obtaining a session key 116 and a session encryption key 120.The session key 116 may be any cryptographic key, certificate, or credential.", "The session key 116 may be generated by the security service 106, may be provided by another service of the computing resource service provider 104, or may be provided by the customer 102.The session encryption key 120 may also be any cryptographic key, certificate, or credential and may be generated by the security service 106 or may be provided by another service by the computing resource service provider 104.In an embodiment, the session key 116 and/or the session encryption key 120 are generated by dedicated hardware and/or software within the computing resource service provider 104 environment configured to generate such keys.", "The security service 106 may then store the session key 116 in a set of session data 124 and may encrypt 118 the session data 124 using the session encryption key 120 to generate 122 a session token 126.Each of these operations is described in more detail below, as is the set of session data 124.The security service 106 may then provide 130 the session token 126 to the customer 102.In the example illustrated in FIG.", "1, because the session token 126 is encrypted using the session encryption key 120, the customer cannot access the session data 124 and may not otherwise alter the session data 124, including the session key 116 stored in the session data 124.Additionally, the security service 106 may provide 128 the session key 116 to the customer 102 so that the customer 102 can use the session key 116 to digitally sign messages and/or requests that are combined with the session token 126 as described herein.", "The examples described below illustrate how the short-term credentials in the session token 126 are combined with the digital signature of the session key 116 to verify requests and/or authenticate messages.", "FIG.", "2 illustrates an example environment 200 where requests are validated using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A customer 202 may use the session token described above to generate a signed request 204.The signed request 204, which includes the session token, is signed by the session key 218.The signed request is illustrated herein with a “lock” symbol in a circle, which represents the session token and the “pen and line” symbol in the square, which represents the digital signature.", "As discussed herein, numerous variations of the cryptographic operations described herein utilize symmetric and/or asymmetric cryptographic primitives.", "Symmetric key algorithms may include various schemes for performing cryptographic operations on data including block ciphers, stream ciphers and digital signature schemes.", "Example symmetric key algorithms include the advanced encryption standard (AES), the data encryption standard (DES), triple DES (3DES), Serpent, Twofish, blowfish, CAST5, RC4, and the international data encryption algorithm (IDEA).", "Symmetric key algorithms may also include those used to generate output of one way functions and include algorithms that utilize hash-based message authentication codes (HMACs), message authentication codes (MACs) in general, PBKDF2 and Bcrypt.", "Asymmetric key algorithms may also include various schemes for performing cryptographic operations on data.", "Example algorithms include those that utilize the Diffie-Hellman key exchange protocol, the digital signature standard (DSS), the digital signature algorithm, the ElGamal algorithm, various elliptic curve algorithms, password-authenticated key agreement techniques, the pallier cryptosystem, the RSA encryption algorithm (PKCS#1), the Cramer-Shoup cryptosystem, the YAK authenticated key agreement protocol, the NTRUEncrypt cryptosystem, the McEliece cryptosystem, and others.", "Elliptic curve cryptography algorithms include the elliptic curve Diffie-Hellman (ECDH) key agreement scheme, the Elliptic Curve Integrated Encryption Scheme (ECIES), the Elliptic Curve Digital Signature Algorithm (ECDSA), the ECMQV key agreement scheme, and the ECQV implicit certificate scheme.", "Other algorithms and combinations of algorithms for symmetric and/or asymmetric cryptographic primitives are considered as being within the scope of the present disclosure and the above is not intended to be an exhaustive list.", "It should be noted that that the term “digital signature” includes any information usable to cryptographically verify authenticity of a message including information generated using an RSA-based digital scheme (such as RSA-PSS), the digital signature algorithm (DSA) and the elliptic curve digital signature algorithm, the ElGamal signature scheme, the Schnorr signature scheme, the Pointcheval-Stern signature algorithm, the Rabin signature algorithm, pairing-based digital signature schemes (such as the Boneh-Lynn-Schacham signature scheme), undeniable digital signature schemes, and others.", "Further, message authentication codes (such as hash-based message authentication codes (HMACs), keyed cryptographic hash functions, and other types of information may also be used as digital signatures.", "As with the above, other algorithms and combinations of algorithms used to provide digital signatures are also considered as being within the scope of the present disclosure and the above is not intended to be an exhaustive list.", "In various embodiments, data objects such as session tokens may be cryptographically verifiable.", "In one example, cryptographically verifiable data objects are created to be cryptographically verifiable by the system to which the data object is to be provided or another system that operates in conjunction with the system to which the data object is to be provided.", "For example, the data object may be encrypted so as to be decryptable by the system that will cryptographically verify the data object, where the ability to decrypt the data object serves as cryptographic verification of the data object.", "As another example, the data object may be digitally signed (thereby producing a digital signature of the data object) such that the digital signature is verifiable by the system that will cryptographically verify the data object.", "In other examples, both encryption and digital signatures are used for cryptographic verifiability and/or security.", "In such examples, the key used to encrypt and/or digitally sign the data object may vary in accordance with various embodiments and the same key is not necessarily used for both encryption and digital signing, where applicable.", "In some embodiments, a key used to encrypt the data object is a public key of a public/private key pair where the private key of the key pair is maintained securely by the system to which the data object is to be provided, thereby enabling the system to decrypt the data object using the private key of the key pair.", "Using the public key to encrypt the data object may include generating a symmetric key, using the symmetric key to encrypt the data object, and encrypting the symmetric key using the public key, where the encrypted symmetric key is provided to a system with the encrypted data object to enable the system to use the corresponding private key to decrypt the symmetric key and use the decrypted symmetric key to decrypt the data object.", "Further, in some embodiments, the data object is digitally signed using a private key of a public/private key pair corresponding to the computer system that encrypts and/or digitally signs the data object (e.g., a user device).", "For example, an application may be provisioned with the private key and the data object may include a certificate for the private key for use by a system for verification of the digital signature of the data object.", "Other variations, including variations where a symmetric key shared between the user computer and the system that cryptographically verifies the data object can be used to encrypt and/or digitally sign the data object.", "The signed request 204 may be received by a security service 220, which may be the same as the security service 106 described in connection with FIG.", "1.The security service 220 may first verify the session token 206 by extracting the session key 210 from the session token 208 that is included in the signed request 204.The security service 220 may extract the session key 210 from the session token 208 by decrypting the session token using the session encryption key.", "The session encryption key, which may be the same as the session encryption key 120 described in connection with FIG.", "1, may be maintained as a secret by the security service 220 using one or more of the methods described herein.", "It should be noted that, unless otherwise specified or made clear from context, “decrypting the session token using the session encryption key” includes decrypting the session token using the same session encryption key that was used to encrypt the session token (i.e., using a symmetric session encryption key), decrypting the session token using a decryption key that corresponds to the session encryption key (i.e., using an asymmetric session encryption key), decrypting the session token using a combination of keys that were used to encrypt the session token (i.e., using multiple session encryption keys), or a combination of these and/or other such cryptographic operations usable to extract the session key from the session token.", "The security service 220 may then verify 212 the signature 214 of the signed request 204 by using the extracted session key 216 obtained by extracting the session key 210 from the session token 208 that is included in the signed request 204 by obtaining the session key 210 from the extracted session data.", "The security service 220 may validate the signature 222 of the signed request by, for example, using the extracted session key 216 to perform a cryptographic operation to validate the digital signature generated by the session key 218.The security service 220 may also validate the signature 222 by using the session key 218 to perform an encryption operation on a data item and then using the extracted session key 216 to perform a corresponding decryption operation on the encrypted data item.", "The security service 220 may also validate the signature 222 by comparing the session key 218 to the extracted session key 216.Finally, if the security service 220 is able to verify the session token 206 and is able to verify 212 the signature 214, the security service may process the request 224 by, for example, providing resources associated with the request and/or forwarding the request to another service of the computing resource service provider.", "In an embodiment, the signed request 204 includes a request for resources from a computing resource service provider such as the computing resource service provider 104 described in connection with FIG.", "1.The request for resources may include an identifier for the resource and/or an identifier for the customer 202.The request for resources may also include a set of policies or permissions for access to the resources or those policies or permissions may be determined after the request for resource is received by the computing resource service provider.", "For example, the request for resources may include a request, by the customer 202, to access a data store provided by a data storage service of the computing resource service provider.", "The request for resources may further specify that the customer desires read-write access to the data store provided by the data storage service of the computing resource service provider.", "Because having read-write access to a data store can have potentially harmful effects, verifying the request using the short-term credentials provided by the session token can help ensure that the customer 202 is authorized to access such resources.", "In another embodiment, the signed request 204 includes a message that is received by the computing resource service provider such as the computing resource service provider 104 described in connection with FIG.", "1 and that must be authenticated by the security service 220 before being processed by the computing resource service provider.", "The message may include an identifier for the customer 202, may include a destination for the message, and may include the content of the message.", "For example, the message may be a message, from the customer 202, to restart one or more virtual machine instances associated with the customer 202.Because restarting virtual machine instances can have harmful effects, authenticating the message using the short-term credentials provided by the session token can help ensure that the customer 202 is authorized to restart the virtual machine instances.", "In an embodiment, the operations to verify the session token 206 and to verify 212 the signature 214 before processing the request 224 (or authorizing the message) are performed by the security service 220 prior to sending the request or the message to a different service of the computing resource service provider.", "In another embodiment, the operations to verify the session token 206 and to verify 212 the signature 214 are performed by the security service 220 after the different service of the computing resource service provider has received the request or the message.", "That is, the different service of the computing resource service provider receives the request or message and forwards the request or message to the security service 220 for verification of the session token and signature.", "In another embodiment, the different service may be configured to verify the session token 206 and/or to verify 212 the signature 214 by, for example, obtaining the session encryption key from the security service.", "FIG.", "3 illustrates an example diagram 300 showing encryption operations associated with using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "The first part of the example diagram 300 illustrated in FIG.", "3 shows how a session key and a session encryption key are used to produce the session token as described above.", "The operations illustrated in the first part of the example diagram 300 may be performed by a security service such as the security service 106 described in connection with FIG.", "1.The session key 302 is added to the unencrypted session data 304.The unencrypted session data (also referred to herein more simply as the “session data”) may contain additional data and/or metadata associated with the session including, but not limited to, identifiers associated with users (or customers), identifiers associated with user (or customer) accounts, identifiers associated with resources, zones of operation (also referred to herein as “regions”) of the computing resource service provider where the session may be used, policies associated with the session, permissions associated with the session, roles associated with the session, keys used to generate the session token, expiration conditions (e.g., dates or times) associated with the session, or other such data and/or metadata associated with the session.", "The session data 304 may be encrypted using the session encryption key 306 as described herein to produce the session token 308.Although not illustrated in the first part of the example diagram 300, the session encryption key may also be preserved as a secret within the security service, stored in a session encryption keychain, or otherwise maintained for later use in the verification operations.", "It should be noted that the session key 302 and the session encryption key 306 are different keys.", "The session key 302 is stored in the session data 304 and is, in some embodiments, provided to the customer.", "The session encryption key 306 is used to encrypt the session data 304 to produce the session token 308 and is maintained as a secret (i.e., is not provided to the customer).", "The second part of the example diagram 300 illustrated in FIG.", "3 shows how some parts of the data sent to the customer 310 in response to the request for the session token are accessible to the customer 310, while some parts of the data sent to the customer 310 in response to the request for the session token are not accessible to the customer 310.In the example illustrated in the second part of the example diagram 300 illustrated in FIG.", "3, the session token 314 is not accessible to the customer 310 as illustrated by the “x-shaped mark” next to the session token 314.The session token 314 may be usable by the customer 310 to generate signed requests as described above, but the customer 310 may not be able to extract the session data 304 to produce extracted session data from the session token because the customer 310 may not have access to the session encryption key 306 (or a corresponding session decryption key).", "Conversely, in the example illustrated in the second part of the example diagram 300 illustrated in FIG.", "3, the session key 312 is accessible to the customer 310 as illustrated by the “check mark” next to the session key 312.The session key 312 may be usable by the customer 310 to digitally sign requests for resources as described above and/or to digitally sign messages also as described above.", "As used herein, the terms “digital signature” and “digitally signing” refer to the process of performing one or more mathematical operations (i.e., cryptographic operations) to provide a means for authenticating the request and/or the message.", "If the digital signature is valid (i.e., it is verified), a service such as the security service 106 described in connection with FIG.", "1 can verify that the request or message was generated by the customer, that the customer cannot later repudiate the message (i.e., cannot later deny that the customer sent the message), and that the message was not tampered with in transit.", "A session key can be used to digitally sign a request or message by using a signing algorithm associated with a digital signature scheme combined with the session key.", "The digital signature can then be verified using a corresponding signature verification algorithm with the session key (or with a corresponding key).", "The third part of the example diagram 300 illustrated in FIG.", "3 shows how the signed request is generated using the session token and signed with the session key.", "In the example illustrated in the third part of the example diagram 300 illustrated in FIG.", "3, the session token 316 is combined with a request 318, and digitally signed 322 using the session key 320.The process to digitally sign the request using the session key 320 may include encrypting the request 318 using the session key 320 based on the signing algorithm associated with the digital signature scheme.", "The process to digitally sign a message using the session key 320 may also include encrypting the message using the session key 320 based on the signing algorithm associated with the digital signature scheme.", "In an embodiment, the signing algorithm used to sign messages is different than the signing algorithm used to sign requests such as the request 318.FIG.", "4 illustrates an example diagram 400 showing decryption operations associated with using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A signed request 402 may be received and the session token 404 used to generate the request may be extracted from the signed request 402.The session data 408 may then be extracted from the session token by using the session encryption key 406.In an embodiment, the session encryption key 406 is the same key that was used to encrypt the session token as described above.", "In another embodiment, the session encryption key 406 is a key corresponding to the key that was used to encrypt the session token but that is different than the key that was used to encrypt the session token.", "For example, the session encryption key 406 and the key that was used to encrypt the session token may be two keys of a public key cryptography key pair, where one of the keys is a public key of the public key cryptography key pair and the other key is a private key of the public key cryptography key pair.", "In such an example, the public key of the public key cryptography key pair may be generated to match the private key of the public key cryptography key pair by, for example, performing one or more key generation operations on the private key to produce the public key.", "After the session data 408 is extracted from the session token by using the session encryption key 406, the session key 412 from the session data 408 extracted from the session token 404 may be used to validate 414 the digital signature 410 as described above.", "In the example illustrated in FIG.", "4, the session key 412 (also referred to herein as the “extracted session key”) may be used to validate 414 the digital signature 410 by using the session key 412 in conjunction with a digital signature verification algorithm associated with the digital signature scheme used to digitally sign the signed request 402 (e.g., Diffie-Hellman, RSA cryptography, Hash trees, Rabin signatures, GMR signatures, elliptic curve cryptography, or some other digital signature scheme).", "As may be contemplated, the digital signature schemes described herein are merely illustrative examples and other such digital signature schemes may be considered as within the scope of the present disclosure.", "FIG.", "5 illustrates an example process 500 for validating requests using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A security service such as the security service 106 described in connection with FIG.", "1 may perform the process illustrated in FIG.", "5.The security service may first receive a request for a session 502 (also referred to herein as receiving a request for a “session token”).", "In an embodiment, the request for a session token is signed with a digital signature using a credential associated with the requester such as, for example, the customer long-term key described above.", "In such an embodiment, the request may first be validated 504 by verifying the credential to ensure that the request for the session was properly generated, that it was generated by the customer, and/or that it was not tampered with during transmission.", "A request that is not valid 506 may cause the security service to generate an error 508 in response to the invalid request.", "The security service may generate an error 508 and send a report of the error to the customer, or to an administrative account associated with the customer, or to a computing device associated with the customer, or to a message log system or service associated with the customer.", "The security service may also communicate the error to the customer using an email, a short message service (“SMS”) message, a console message, an application programming interface (“API”) call (also referred to herein as an application programming interface request), a webservice call, a library call, or some other such communication modality.", "Similarly, the security service may generate an error 508 and report the error to a user, account, device, or message log service associated with the security service and/or with the computing resource service provider.", "For example, a report of the error may be sent to an access monitoring service that monitors attempted access to resources associated with the computing resource service provider in order to identify potential malicious attacks.", "As may be contemplated, the actions taken by the security service in response to a request that is not valid described herein are illustrative examples and other such responses to requests that are not valid may be considered as within the scope of the present disclosure.", "If the request for a session token is valid because, for example, the credentials associated with the request are verified, the security service may then obtain 510 a session key for the session.", "In an embodiment, the session key is obtained by generating the session key using a key generation algorithm associated with the encryption scheme for the session keys.", "In another embodiment, the session key is obtained by selecting the session key from a plurality of pre-generated session keys.", "In another embodiment, the session key is received from the requester (e.g., the customer) associated with the request for the session token.", "In such an embodiment, the session key may be included with the request for the session token or the session key may be received by the security service in response to a request sent to the customer.", "After obtaining the session key, the security service may then store 512 the session key in the session data as described above.", "The security service may then obtain 514 a session encryption key usable to encrypt the session data to produce the session token.", "In an embodiment, the session encryption key is obtained by generating the session encryption key using a key generation algorithm associated with the encryption scheme for the session encryption keys.", "In such an embodiment, the encryption scheme for the session encryption keys may be different from the encryption scheme for the session keys.", "In another embodiment, the session encryption key is obtained by selecting the session encryption key from a plurality of pre-generated session encryption keys.", "In another embodiment, the session encryption key is generated from a combination of personal and global keys as described below.", "In an embodiment, the session encryption key is a designated key of a plurality of keys maintained by the security service in a session encryption keychain.", "For example, a plurality of session encryption keys may be maintained by the security service in a session keychain with a corresponding time interval.", "Periodically (e.g., each hour) a new session encryption key may be generated and stored in the session encryption keychain and an oldest session encryption key (i.e., the key that was generated the longest time ago) may be deleted, invalidated, or otherwise removed from use.", "In such an embodiment, the newest key may be designated for use as the session encryption key (i.e., may be the only key used to encrypt the session data to generate the session token) while the other keys may be used to decrypt the session token to extract the session data.", "After obtaining the session encryption key, the security service may then use the session encryption key to encrypt 516 the session data to generate the session token as described above.", "The security service may then verify 518 the session token by performing one or more cryptographic operations on the session token (e.g., the security service may use the session encryption key and/or a corresponding key to decrypt the session token and compare the results to the session data).", "If the security service is not able to verify 518 the session token, the security service may generate 508 an error as described above.", "If the security service is able to verify 518 the session token, the security service may provide 520 the session token and the session key to the requester.", "In an embodiment where the requester has provided the session key, the security service may provide 520 only the session token to the requester.", "FIG.", "6 illustrates an example process 600 for using a session token to generate resource requests using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A security service such as the security service 106 described in connection with FIG.", "1 may perform the process illustrated in FIG.", "6.The security service may first receive 602 a request for resources or a message as described above.", "The request for resources or the message may be digitally signed by a session key and may also be generated using a session token, also as described above.", "Next, the security service may extract 604 the session key from the session token used to generate the session token and may validate 606 the digital signature using the extracted session key.", "If the signature is valid 608 (i.e., if the request or the message is authenticated), the security service may next process 610 the request or the message by, for example, providing access to the resources, processing the message, or performing some other action.", "If the signature is not valid 608 (i.e., if the request or the message is not authenticated) the security service may generate 612 an error as described above.", "FIG.", "7 illustrates an environment 700 where session credentials are generated with asymmetric keys using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A customer 702 of a computing resource service provider 704 may generate a session request 708 from a security service that may be used as a short-term credential and which may be used to authenticate messages from the customer 702 to the computing resource service provider 704 and which may also be used to generate requests for resources from the computing resource service provider 704.The customer 702, the computing resource service provider 704, and the security service 706 may be the same as the customer 102, the computing resource service provider 104, and the security service 106 described above in connection with FIG.", "1.The session request 708 may be digitally signed 734 by the customer so that the security service 706 may validate 710 the session request.", "In the example illustrated in FIG.", "7, the session request 708 is digitally signed 734 with a customer long-term key 732 associated with the customer 702.As described above, a customer long-term key 732 is a secure credential with a long-term period of validity (e.g., three months, six months, or more) that is uniquely associated with the customer 702.In another embodiment, the session request 708 is digitally signed 734 with a username and password of an account associated with the customer 702.In another embodiment, the session request is digitally signed 734 with a short-term credential such as those described herein (i.e., a session request 708 may be digitally signed 734 by a session token that may be specific to such requests).", "In another embodiment, the session request is digitally signed 734 by a certificate such as, for example, an X.509 certificate, or some other public or identify certificate.", "In another embodiment, the session request is digitally signed 734 by a combination of such cryptographic methods.", "As may be contemplated, the examples of cryptographic methods that may be used to digitally sign the session request described herein are illustrative examples and other such cryptographic methods that may be used to digitally sign the session request may be considered as within the scope of the present disclosure.", "When the security service 706 receives the session request 708 that is digitally signed 734 by, for example, the customer long-term key 732, the security service may first validate 710 the session request.", "Operations to validate 710 the session request may include, but may not be limited to validating the identity of the customer 702, validating that the customer 702 is authorized to generate the session request 708, validating that the customer account used to generate the request is authorized to generate the session request 708, and/or validating that the request came from a computing device associated with the customer 702 that is authorized to generate the session request 708.In the example illustrated in FIG.", "7, the security service 706 validates the request by verifying that the session request 708 is digitally signed 734 by the customer long-term key 732 and that the customer long-term key 736 is being used by the customer 702 associated with the key.", "Although not illustrated in FIG.", "7, in the event that the session request 708 is not valid (i.e., that one or more of the operations to validate 710 the session request may yield a result indicating the request is not valid), an error may be generated and/or one or more notifications may be sent to the customer, an administrator, or some other such entity.", "If the session request 708 is valid 712, the security service 706 may then process 714 the request.", "The security service 706 may first process 714 the request by obtaining a session key pair 716 and a session encryption key 720.The session key pair 716 may be any cryptographic key, certificate, or credential with a public entity (e.g., a public key) and a private entity (e.g., a private key).", "The session key pair 716 may be generated by the security service 706 or may be provided by another service of the computing resource service provider 704.In embodiment, the public key portion of the session key pair 716 may be provided by the customer 702 while the private key portion of the session key pair 716 may be maintained as a secret by the customer 702.The session encryption key 720 may also be any cryptographic key, certificate, or credential and may be generated by the security service 706 or may be provided by another service by the computing resource service provider 704.In an embodiment, the session key pair 716 and/or the session encryption key 720 are generated by dedicated hardware and/or software within the computing resource service provider 704 environment configured to generate such keys.", "The security service 706 may then store 718 the public session key of the session key pair 716 in a set of session data 724 and may encrypt 722 the session data 724 using the session encryption key 720 to generate 722 a session token 726.The security service 706 may then provide 730 the session token 726 to the customer 702.In the example illustrated in FIG.", "7, because the session token 726 is encrypted using the session encryption key 720, the customer cannot access the session data 724 and may not otherwise alter the session data 724, including the public session key of the session key pair 716 stored in the session data 724.Additionally, the security service 706 may provide 728 the private session key of the session key pair 716 to the customer 702 so that the customer 702 can use the private session key of the session key pair 716 to digitally sign messages and/or requests that are combined with the session token 726 as described herein.", "In an embodiment where the customer provides the public session key to the security service and maintains the private session key as a secret, the security service does not provide 728 the private session key of the session key pair 716 to the customer 702.The examples described below illustrate how the short-term credentials in the session token 726 are combined with the digital signature of the private session key of the session key pair 716 to verify requests and/or authenticate messages.", "FIG.", "8 illustrates an environment 800 where requests are validated using session credentials with asymmetric keys using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A customer 802 may use the session token described above to generate a signed request 804.The signed request 804, which includes the session token, is signed by the private session key 818.The signed request is illustrated herein with a “lock” symbol in a circle, which represents the session token and the “pen and line” symbol in the square, which represents the digital signature.", "The signed request 804 may be received by a security service 820, which may be the same as the security service 106 described in connection with FIG.", "1.The security service 820 may first verify the session token 806 by extracting the public session key 810 from the session token 808 that is included in the signed request 804.The security service 820 may extract the public session key 810 from the session token 808 to produce an extracted public key by, for example, decrypting the session token using the session encryption key or a session decryption key corresponding to the session encryption key.", "The session encryption key, which may be the same as the session encryption key 120 described in connection with FIG.", "1, may be maintained as a secret by the security service 820 using one or more of the methods described herein.", "The security service 820 may then verify 812 the signature 814 of the signed request 804 by using the extracted public session key 816 obtained by extracting the public session key 810 from the session token 808 that is included in the signed request 804.The security service 820 may validate the signature 822 of the signed request by, for example, using the extracted public session key 816 to perform a cryptographic operation to validate the digital signature generated by the private session key 818.If the security service 820 is able to verify the session token 806 and is able to verify 812 the signature 814, the security service may process the request 824 by, for example, providing resources associated with the request and/or forwarding the request to another service of the computing resource service provider.", "In an embodiment, the operations to verify the session token 806 and to verify 812 the signature 814 before processing the request 824 (or authorizing the message) are performed by the security service 820 prior to sending the request or the message to a different service of the computing resource service provider.", "In another embodiment, the operations to verify the session token 806 and to verify 812 the signature 814 are performed by the security service 820 after the different service of the computing resource service provider has received the request or the message.", "That is, the different service of the computing resource service provider receives the request or message and forwards the request or message to the security service 820 for verification of the session token and signature.", "In another embodiment, the different service may be configured to verify the session token 806 and/or to verify 812 the signature 814 by, for example, obtaining the session encryption key from the security service.", "FIG.", "9 illustrates a diagram 900 showing encryption operations associated with using session credentials with asymmetric keys using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "The first part of the diagram 900 illustrated in FIG.", "9 shows how a public session key and a session encryption key are used to produce the session token as described above.", "The operations illustrated in the first part of the diagram 900 may be performed by a security service such as the security service 106 described in connection with FIG.", "1 The public session key 902 is added to the unencrypted session data 904.The session data 904 may be encrypted using the session encryption key 906 as described herein to produce the session token 908.As described above, although not illustrated in the first part of the diagram 900, the session encryption key may also be preserved as a secret within the security service, stored in a session encryption keychain, or otherwise maintained for later use in the verification operations.", "It should be noted that the public session key 902 and the session encryption key 906 are different keys.", "The public session key 902 is stored in the session data 904 and is accessible by the customer.", "The session encryption key 906 is used to encrypt the session data 904 to produce the session token 908 and is maintained as a secret (i.e., is not accessible by the customer).", "The second part of the diagram 900 illustrated in FIG.", "9 shows how some parts of the data sent to the customer 910 in response to the request for the session token are accessible to the customer 910, while some parts of the data sent to the customer 910 in response to the request for the session token are not accessible to the customer 910.In the example illustrated in the second part of the diagram 900 illustrated in FIG.", "9, the session token 914 is not accessible to the customer 910 as illustrated by the “x-shaped mark” next to the session token 914.The session token 914 may be usable by the customer 910 to generate signed requests as described above, but the customer 910 may not be able to extract the session data 904 from the session token because the customer 910 may not have access to the session encryption key 906 (or a corresponding session decryption key).", "Conversely, in the example illustrated in the second part of the diagram 900 illustrated in FIG.", "9, the private session key 912 is accessible to the customer 910 as illustrated by the “check mark” next to the private session key 912.As described above, the private session key may be provided by the customer in some embodiments.", "The private session key 912 may be usable by the customer 910 to digitally sign requests for resources as described above and/or to digitally sign messages also as described above.", "The third part of the diagram 900 illustrated in FIG.", "9 shows how the signed request is generated using the session token and signed with the private session key.", "In the example illustrated in the third part of the diagram 900 illustrated in FIG.", "9, the session token 916 is combined with a request 918, and digitally signed 922 using the private session key 920.The process to digitally sign the request using the private session key 920 may include encrypting the request 918 using the private session key 920 based on the signing algorithm associated with the digital signature scheme.", "The process to digitally sign a message using the private session key 920 may also include encrypting the message using the private session key 920 based on the signing algorithm associated with the digital signature scheme.", "In an embodiment, the signing algorithm used to sign messages is different than the signing algorithm used to sign requests such as the request 918.FIG.", "10 illustrates a process 1000 for validating requests using session credentials with asymmetric keys using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A security service such as the security service 106 described in connection with FIG.", "1 may perform the process illustrated in FIG.", "10.The security service may first receive a request for a session 1002 (also referred to herein as receiving a request for a “session token”).", "In an embodiment, the request for a session token is signed with a digital signature using a credential associated with the requester such as, for example, the customer long-term key described above.", "In such an embodiment, the request may first be validated 1004 by verifying the credential to ensure that the request for the session was properly generated, that it was generated by the customer, and/or that it was not tampered with during transmission.", "A request that is not valid 1006 may cause the security service to generate an error 1008 in response to the invalid request as described above.", "If the request for a session token is valid because, for example, the credentials associated with the request are verified, the security service may then obtain 1010 a pair of session keys for the session.", "In an embodiment, the pair of session keys is obtained by generating the session keys using a key generation algorithm associated with the encryption scheme for the session keys.", "In such an embodiment, the private session key may be generated first and the public session key generated based at least in part on the private session key.", "In another embodiment, the session keys are obtained by selecting one or both of the session keys from a plurality of pre-generated session keys.", "In another embodiment, the private and/or the public session keys are received from the requester (e.g., the customer) associated with the request for the session token.", "In such an embodiment, the session keys may be included with the request for the session token or the session keys may be received by the security service in response to a request sent to the customer.", "After obtaining the session keys, the security service may then store 1012 the public session key in the session data as described above.", "The security service may then obtain 1014 a session encryption key usable to encrypt the session data to produce the session token.", "In an embodiment, the session encryption key is obtained by generating the session encryption key using a key generation algorithm associated with the encryption scheme for the session encryption keys.", "In such an embodiment, the encryption scheme for the session encryption keys may be different from the encryption scheme for the session keys.", "In another embodiment, the session encryption key is obtained by selecting the session encryption key from a plurality of pre-generated session encryption keys.", "In another embodiment, the session encryption key is generated from a combination of personal and global keys as described below.", "After obtaining the session encryption key, the security service may then use the session encryption key to encrypt 1016 the session data to generate the session token as described above.", "The security service may also verify 1018 the session token by performing one or more cryptographic operations on the session token (e.g., the security service may use the session encryption key and/or a corresponding key to decrypt the session token and compare the results to the session data).", "If the security service is not able to verify 1018 the session token, the security service may generate 1008 an error as described above.", "If the security service is able to verify 1018 the session token, the security service may provide 1020 the session token and the private session key to the requester.", "In an embodiment where the requester has provided the private session key, the security service may provide 1020 only the session token to the requester.", "FIG.", "11 illustrates an example environment 1100 where a session associated with a region is retrieved using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "As used herein, a “region” is a logical and/or physical partitioning of the resources provided by a computing resource service provider.", "As described above, a computing resource service provider may host a variety of services and provide a variety of resources in multiple locations.", "Each of these locations may include one or more regions (also referred to herein as “zones”), which are logical and/or physical partitions of the services and/or resources.", "For example, a first datacenter in a first location (a physical or geographical location) may encompass a single region, which may be identified by that datacenter and/or that location.", "Conversely, a second datacenter in a second location may encompass multiple logical regions.", "Additionally, a region may include multiple physical locations such as, for example, a region identified by a collection of datacenters in one or more countries (e.g., “Western Europe”).", "Regions provide additional data security for customers by limiting access to resources to users or accounts within that region.", "For example, a customer may have multiple customer accounts and may have data and/or resources located in multiple regions.", "Such a customer may have a default policy that limits access to the resources in a first region to accounts that are authorized in that first region and that limits access to the resources in a second region to accounts that are authorized in that second region.", "Thus, a first region user account would not have access to second region resources and a second region user account would not have access to first region resources.", "In the example illustrated in FIG.", "11, a customer 1102 uses a customer credential (e.g., a long-term key) to sign a session request 1104 as described above.", "The customer 1102 may issue a request from an account authorized in the first region (referred to herein as a “first region account”) to a first region security service 1106 (i.e., a security service in that first region) that has authorization credentials usable to validate the account in the first region.", "It should be noted that an account that is not authorized in a particular region (e.g., the first region) may not generally be used to access services and/or resources in that region because there is no method to validate the customer credentials in that first region in order to determine whether the account is authorized to access those services and/or resources.", "Services generally have a policy to deny unknown users and, when accounts are regional, those accounts are unknown in regions where they are not authorized.", "It should also be noted that an account may be authorized in multiple regions by propagating authorization credentials usable to authorize the account to those multiple regions.", "The first region security service 1106 may validate 1108 the session request 1104 by validating the digital signature of the session request as described above.", "The first region security service 1106 may also validate 1110 that the customer 1102 is authorized for the first region, also as described above.", "In an embodiment, when the security service validates the session request by validating the digital signature of the session request, that serves to validate 1110 that the customer 1102 is authorized for the first region.", "In an embodiment, the first region security service 1106 validates the customer before validating the session request.", "In another embodiment, the first region security service 1106 validates the session request before validating the customer.", "After the request and/or the customer is validated, the first region security service 1106 may provide 1112 a session token 1114 to the customer as described above and may also, in some embodiments, provide the session key used for signing requests and messages.", "The session token 1114 may be usable only in the first region or may be usable in multiple regions.", "The region or regions where the session token is usable may be included in the session data that is encrypted to produce the session token.", "The region or regions where the session token is usable may also be stored in a policy and permission service so that, for example, the service records a session identifier and associates a list of allowable regions where the session token may be used with that session identifier.", "The region or regions where the session token is usable may also be determined by where the session encryption key (i.e., the key used to encrypt the session token) or a corresponding session decryption key (i.e., the key corresponding to the key used to encrypt the session token that may be used to decrypt the session token) may be propagated.", "That is, if the session encryption key or the session decryption key is propagated only to the first region, then the session token may generally only be usable in that first region.", "FIG.", "12 illustrates an example environment 1200 where a retrieved session is used across regions using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A customer 1202 may use a session token such as the session token 1114 described in connection with FIG.", "11 to generate 1204 a request.", "In the example illustrated in FIG.", "12, the customer account is authorized in the first region, the customer account is not authorized in the second region, and the session token is generated in first region.", "The request illustrated in FIG.", "12 is denoted as a first region signed request 1206, meaning that the request is generated in the first region, signed with first region credentials (in this case, the first region session key provided by the security service) and includes a session token usable in the first region.", "In the second region 1208, a service such as the security service 106 described in connection with FIG.", "1 may determine that the signature and/or the session token is not usable in the second region 1208 and that the signature and/or the session token is associated with a first region 1220.The service may then request 1210 that the first region 1220 provide a session usable in the second region.", "The customer account associated with the customer 1202 and used to generate 1204 the request may be authorized in the second region 1208.In an embodiment, the service in the second region 1208 will validate the customer prior to generating the request 1210 to the first region 1220 to provide a session usable in the second region.", "In another embodiment, the service in the second region 1208 will validate the customer after receiving a response to the request 1210 to the first region 1220 to provide a session usable in the second region.", "The request 1214 to the first region 1220 to provide a session usable in the second region may be a signed request such as those described herein.", "The request 1214 may be digitally signed 1218 by a second region credential and may include the first region signed request 1216 which may be the same as the first region signed request 1206.The request 1214 to the first region 1220 to provide a session usable in the second region and that is signed 1218 by a second region credential is denoted as a second region signed request, meaning that the request is digitally signed in the second region.", "In the example illustrated in FIG.", "12, the request 1214 to the first region 1220 to provide a session usable in the second region includes a request that is denoted as a first region signed request 1216, meaning that it is digitally signed with first region credentials (in this case, the first region session key provided by the security service) and includes a session token usable in the first region.", "It should be noted that the credentials used to sign the request 1214 to the first region 1220 to provide a session usable in the second region must be verifiable in the first region so that, for example, a first region may validate the request 1214.In an embodiment, the request 1214 to the first region 1220 to provide a session usable in the second region is signed by a private key associated with the second region.", "In such an embodiment, the service in the second region configured to validate the request 1214 may do so by obtaining a corresponding public key from the second region such as, for example, a key corresponding to the private key used to digitally sign the request 1214.When the request 1214 to the first region 1220 to provide a session usable in the second region is received at the first region 1220, a service (e.g., a security service) of the first region 1220 may validate the request as described above and then may decrypt 1222 the session token to extract the session data.", "The service of the first region 1220 may then encrypt 1224 the session data using credentials usable in the second region 1208.In an embodiment, the service of the first region 1220 uses a public key provided by the second region 1208 to encrypt the 1224 the session so that a service in the second region 1208 can use a corresponding private key to decrypt the session and generate a session usable in the second region 1208.After the second region 1208 receives the encrypted second region session token 1226, the second region 1208 may decrypt the encrypted second region session token 1226 and may use the session to process 1230 the request.", "In an embodiment, the second region 1208 caches 1228 the decrypted second region session token (also referred to herein as a cached session token) so that the session token may be used to process further requests.", "In another embodiment, the second region 1208 discards the decrypted second region second token after processing the request so that the session token may not be used to process further requests.", "FIG.", "13 illustrates an example environment 1300 where session data is used across regions to generate a cross-region session using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A service such as the security service 106 described in connection with FIG.", "1 generates a cross-region resource request.", "A cross-region resource request is a request where a second region signed request 1304 that contains a first region signed request 1306 is used to provide a session usable in the second region from the request generated in the first region as described above.", "In the example illustrated in FIG.", "13, the second region signed request 1304 is a request to the first region 1308 to provide a session usable in the second region 1302 and the first region signed request 1306 is a request for resources or a message to the second region as described above in connection with FIG.", "12.A service of the first region 1308 may first decrypt 1312 the session token using the session encryption key 1314 as described herein.", "The resulting session data 1316 may then be encrypted 1318 using a session encryption key selected so that the second region 1302 can use the session.", "In the example illustrated in FIG.", "13, the first region 1308 uses a second region public key 1320 that is obtained from the second region 1302 to encrypt the session data 1316.The resulting session includes the session data 1316, but is a second region session 1322 due to being encrypted by the second region public key 1320.When the second region session 1322 is received at the second region 1302, a service of the second region 1302 may then use the second region private key 1324 that corresponds to the second region public key to extract the session data, validate 1326 the session and use 1328 the session to process requests and/or authenticate messages.", "FIG.", "14 illustrates an example process 1400 for generating a cross-region session using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "One or more security services such as the security service 106 described in connection with FIG.", "1 may perform a part of the process described in FIG.", "14.A computing device associated with a customer such as the customer 102 described in connection with FIG.", "1 may also perform a part of the process described in FIG.", "14.The example process 1400 illustrated in FIG.", "14 shows the actions of the customer 1402 (e.g., of a device associated with a user account of the customer), the actions of a service (e.g., a security service such as the security service 106 described in connection with FIG.", "1) of a first region 1408, and the actions of a service (e.g., a security service such as the security service 106 described in connection with FIG.", "1) of a second region 1416 to request, generate, and use a cross-region session such as those described above.", "The customer 1402 may first request 1404 a session from the first region 1408 using credentials verifiable in the first region 1408 such as, for example, a long-term session key that is verifiable in the first region 1408.It should be noted that, as used herein, the actions of the customer 1402 to send and/or receive requests and responses from the services may be understood to be sent and/or received from a computing device associated with the user account of the customer.", "Similarly, the actions ascribed to the first region 1408 and/or the second region 1416 may be understood to be performed by the services associated with the respective regions such as, for example, the security services.", "The service in the first region 1408 may receive the request and, after validating the request, may generate 1406 a session token as described above.", "The service in the first region 1408 may then send 1410 the session token to the customer 1402 also as described above.", "The customer 1402 may then receive 1412 the session token and may use the session token generated to send 1414 a signed request to the second region 1416 using the session token such as the first region signed request 1206 described in connection with FIG.", "12.The service in the second region 1416 may first verify 1418 the signed request and may then identify 1420 the origin session (e.g., the first region 1408) based at least in part on, for example, a region identifier included in the signed request.", "The service in the second region 1416 may then send 1422 a signed request for a new session usable in the second region 1416 to the identified first region 1408 as described above.", "The signed request for a new session usable in the second region 1416 sent from the second region 1416 to the first region 1408 may be a second region signed request such as the second region signed request 1214 described in connection with FIG.", "12.The service in the first region 1408 may then verify 1424 the second region signed request and may extract 1426 the session data using the session encryption key used to generate 1406 the session token or a session decryption key corresponding to the session encryption key used to generate 1406 the session token.", "Finally, the service in the first region 1408 encrypt 1428 the session data into a session token usable in the second region 1416 using, for example, a public key of the second session as described above and may send 1430 the encrypted session token usable in the second region to the service in the second region 1416.When the service in the second region 1416 receives the encrypted session token usable in the second region, the service in the second region 1416 may decrypt 1432 the encrypted session token usable in the second region using, for example, a private key corresponding to public key that was used by the service of the first region 1408 to encrypt the encrypted session token usable in the second region.", "The service of the second region 1416 may then cache 1434 the decrypted session token as a cached session token for later use and may also use the decrypted session token to respond 1436 to the request for resources.", "The customer 1402 may receive 1438 the response to the request, which may include access to resources, an indication that a message was authenticated, or some other response.", "FIG.", "15 illustrates an example process 1500 for extracting session data from a cross-region session using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A security service such as the security service 106 described in connection with FIG.", "1 may perform the process described in FIG.", "15.A service of a first region may receive 1502 a signed request for a new session from a second region and may verify 1504 the request as described above.", "If the request is not verified 1506, an error may be generated 1508 such as the error 508 described in connection with FIG.", "5.If the request is verified 1506, the service of the first region may decrypt 1510 the session token using a session encryption key or a key corresponding to the session encryption key and extract 1512 the session data including, but not limited to, a session key of a symmetric session, a public session key of an asymmetric session, a session identifier, a region identifier, or a combination of data items as described herein.", "The service of the first region may then use credentials provided by the second region (also referred to herein as the “other region”) to encrypt 1514 a new session token that is usable in the other region.", "Finally, the service of the first region may send 1516 the new session token to the other region so that the new session may be used in the other region to provide access to resources in response to resource requests from the customer and/or to authenticate messages from the customer.", "FIG.", "16 illustrates an example environment 1600 where a cross-region session is validated using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "The example illustrated in FIG.", "16 follows after the example illustrated in FIG.", "11 where a session associated with a region is retrieved using session credentials.", "In the example illustrated in FIG.", "11, a customer uses a customer credential to sign a session request (i.e., a request for a session token).", "The first region security service may then validate the session request and also validate that the customer is authorized for the first region.", "After the request and/or the customer is validated, the first region security service may provide a session token to the customer and may also, in some embodiments, provide the session key used for signing requests and messages.", "The session token described in connection with FIG.", "11 may be usable only in the first region or may be usable in multiple regions as described above.", "A customer 1602 may use a session token such as the session token 1114 described in connection with FIG.", "11 to generate 1604 a request.", "In the example illustrated in FIG.", "16, the customer account is authorized in the first region, the customer account is not authorized in the third region (which may be different than the second region described in connection with FIG.", "11), and the session token is generated in first region.", "The customer account may not be authorized in the third region because, for example, the third region may be an untrusted region (i.e., may be a region that the computing resource service provider, the customer, or both the customer and the computing resource service provider do not wish to have data and or credentials stored or accessed therein).", "The request illustrated in FIG.", "16 is denoted as a first region signed request 1606, meaning that the request is generated in the first region, signed with first region credentials (in this case, the first region session key provided by the security service) and includes a session token usable in the first region.", "In the third region 1608, a service such as the security service 106 described in connection with FIG.", "1 may determine that the signature and/or the session token is not usable in the third region 1608 and that the signature and/or the session token is associated with a first region 1620 as described above.", "The service may then request 1610 that the first region 1620 provide a session usable in the third region 1608.The request 1614 may be digitally signed 1618 by a third region credential as described above.", "The request 1614 to the first region 1620 to provide a session usable in the third region and that is signed 1618 by a third region credential is denoted as a third region signed request, meaning that the request is digitally signed in the third region.", "In the example illustrated in FIG.", "16, the request 1614 to the first region 1620 to provide a session usable in the third region includes a request that is denoted as a first region signed request 1616, meaning that it is digitally signed with first region credentials (in this case, the first region session key provided by the security service) and includes a session token usable in the first region.", "When the request 1614 to the first region 1620 to provide a session usable in the third region is received at the first region 1620, a service (e.g., a security service) of the first region 1620 may first determine whether the request is allowed 1622 based on an access policy 1630 associated with the first region 1620.For example, if the account associated with the customer 1602 is not authorized to operate in the third region 1608, the request may not be allowed 1622.In another example, if the third region is an untrusted region (i.e., the third region is not trusted by the computing resource service provider or by the customer 1602), the request may not be allowed 1622.In a third example, if the request is a request for resources and the resources are not available in the third region 1608, the request may not be allowed 1622.As may be contemplated, the reasons why a request may not be allowed that are described herein are illustrated examples and other such reasons why a request may not be allowed may be considered as within the scope of the present disclosure.", "If the request is not allowed 1622, the service associated with the first region 1620 may generate 1624 an error as described above.", "Conversely, if the request is allowed 1622, the service of the first region may process 1626 the request by, for example, validating the request, decrypting the session token to extract the session data, and encrypting the session data using credentials usable in the third region 1608 as described above at least in connection with FIG.", "12.After the third region 1608 receives the encrypted third region session token 1628, the third region 1608 may decrypt the encrypted third region session token and may use 1632 the session to process requests and/or to authenticate messages.", "FIG.", "17 illustrates an example environment 1700 where a service intercepts a session using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A customer 1702 uses a signed first region session 1704 to connect to a first region 1706 and, during transmission of the request, the session is intercepted 1708 and sent 1710 to a third region 1712.In the example illustrated in FIG.", "17, a service in the third region 1712 (e.g., a security service such as the security service 106 described in connection with FIG.", "1), may have the first region session 1714, but may not able to perform any operations associated with that session.", "For example, the third region may not be able to perform operations to verify the signature 1716 of the first region session 1714 because the third region 1712 may not have access to the necessary credentials.", "As described above, the session key used to sign the first region session 1714 may be, for example, a symmetric key or an asymmetric key.", "If the session key used to sign the first region session is a symmetric key, the service in the third region 1712 may not have access to the verifying key (e.g., the session key 1724) because that key is stored in the encrypted session token and the encrypted session token cannot be decrypted without the session encryption key 1722 or a decryption key corresponding to the session encryption key 1722.Unless the service in the third region 1712 can obtain the session encryption key 1722 or a decryption key corresponding to the session encryption key 1722 as described above, the service in the third region 1712 cannot verify the symmetric session key.", "It should be noted that, if the session key used to sign the first region session is an asymmetric key, the service in the third region 1712 may be able to obtain access to the verifying key if that verifying key is, for example, a public key 1726 corresponding to the private key used to sign the first region session.", "However, the service in the third region 1712 may still not be able to extract the session data 1718 and/or use that session data to generate a new request 1720 without access to the session encryption key 1722 or a decryption key corresponding to the session encryption key 1722.Again, unless the service in the third region 1712 is able to obtain the session encryption key 1722 or a decryption key corresponding to the session encryption key 1722 as described above, the service in the third region 1712 may not extract the session data 1718 from the encrypted session token and also may not generate a new request 1720 to, for example, masquerade as a service in the first region 1706.In the example illustrated in FIG.", "17, the session is intercepted 1708 during transmission of the request by, for example, a malicious actor.", "However, the operations illustrated in the third region 1712 that cannot be performed because of lack of access to the first region session credentials (e.g., the session encryption key 1722 and/or the session key 1724) may also be not performable if the signed first region session 1704 was deliberately sent to the third region (e.g., in a request for resources), or if the account associated with the customer 1702 is not authorized in the third region 1712, or for some other reason.", "FIG.", "18 illustrates an example environment 1800 where an account key and a global key are used to generate a session key for use in generating session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "As described above, a session encryption key is used to encrypt the session data 1808 that contains the session key 1806, which may be a symmetric session key or a public key of an asymmetric session key pair.", "The resulting session token 1812 and, in some embodiments, the session key 1806 are sent to the customer 1814 so that the customer 1814 can use the session token 1812 and the session key 1806 to generate signed requests for resources and/or to authenticate messages.", "In the example illustrated in FIG.", "18, the session encryption key 1810 used to encrypt the session data 1808 to produce the session token 1812 is generated from two different keys.", "The first key is an account key 1802, which is a credential associated with the customer 1814 or a user account associated with the customer 1814.The account key 1802 may be a key uniquely associated with the customer 1814 and/or the user account associated with the customer so that, for example, each customer and/or each user account has a key only used for that customer or that user account.", "In an embodiment, a single account key is assigned to each customer so that each customer has one unique account key (i.e., no two customers have the same account key).", "In another embodiment, a single account key is assigned to each user account so that each user account has one unique account key (i.e., no two user accounts have the same account key).", "In another embodiment, each customer has multiple account keys that are not shared with any other account key.", "For example, a customer may have multiple roles, users, identities, or accounts associated with the customer.", "In such an example, the customer may assign account keys according to policies or procedures associated with those roles, users, identities, or accounts.", "In yet another embodiment, each user account has multiple account keys that are not shared with other user accounts.", "An account key may be generated by a service such as the security service 106 described in connection with FIG.", "1, and may be maintained as secrets by that service so that, for example, they are uniquely associated with a user account but never communicated to a user associated with that account.", "The second key used to generate the session encryption key is a global session key 1804 which may be maintained as a secret by the security service as described above.", "It should be noted that a global session key should not be construed as meaning a key corresponding to a session key such as the session key 116 described in connection with FIG.", "1.A global session key is used to generate, and is only related to, a session encryption key such as the session encryption key 120 described in connection with FIG.", "1.The global session key 1804 may be shared by a plurality of regions such as those described above.", "For example, in a computing resource service provider environment where there are four regions as described above, the global session key 1804 may be shared with each of the four regions and used by a security service in each of the four regions to generate session encryption keys as described herein.", "It should be noted that, although the examples illustrated and described herein show the generation of the session encryption key 1810 from the account key 1802 and the global session key 1804, this is not to imply that a session encryption key 1810 must be generated as a separate operation from the operation of encrypting the session data 1808 to produce the session token 1812.For example, the session data 1808 can, in some embodiments, be encrypted using the account key 1802 and the global session key 1804 to produce the session token 1812 without the intermediary step of generating the session encryption key 1810.FIG.", "19 illustrates an example environment 1900 where an account key is distributed to different regions for use in isolating regions using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "In the example illustrated in FIG.", "19, a global session key 1904 is propagated (i.e., made available to) a first region 1906, a second region 1910, and a third region 1912.The first region 1906, the second region 1910, and the third region 1912 are regions that are trusted by the computing resource service provider.", "As used herein, a region that is “trusted” by the computing resource service provider is a region where, for example, proper security protocols have been implemented.", "A region may be “untrusted” if, for example, it has become compromised or it has not implemented the proper safety protocols, or it is outside of the computing resource service provider environment (e.g., if it is a third party region).", "In the example illustrated in FIG.", "19, there is a fourth region 1914 that is untrusted (also referred to herein as “not trusted”) and the global session key has not been propagated to this fourth region 1914 so that the fourth region 1914 may not be able to encrypt session data to produce session tokens as described herein.", "In the example illustrated in FIG.", "19, the global session key 1904 is shown as a single global session key that is propagated to the first region 1906, the second region 1910, and the third region 1912 and that is not propagated to the fourth region 1914.In an embodiment, each region has a different global session key (also referred to herein as a “regional session key”).", "In another embodiment, each region has a regional session key in addition to the global session key 1904.In another embodiment, the global session key 1904 is one of a plurality of global session keys maintained in, for example, a session encryption keychain as described herein.", "In the example illustrated in FIG.", "19, an account key 1902 is propagated to the first region 1906, the second region 1910, and the fourth region 1914 according to a set of policies and permissions 1908.The first region 1906 and the second region 1910 are regions that are trusted by the customer and thus are regions that, by the policies and permissions 1908, are regions where the customer or a user account associated with the customer may request a session token.", "Conversely, the third region 1912 is a region that, while trusted by the computing resource service provider, is not trusted by the customer.", "For example, the customer may have resources in the third region that should not be made available to a first region only user account as described herein.", "The policies and permissions 1908 associated with the user account may, in this example, be configured to prevent the user account from being able to generate a session token in the third region and, therefore, the third region may be untrusted by the customer for this account (also referred to herein as “restricted”).", "In the example illustrated in FIG.", "19, the account key 1902 is shown as being propagated to the fourth region 1914 because, even though the fourth region 1914 may be untrusted by the computing resource service provider, the fourth region 1914 may be trusted by the customer.", "It should be noted that the account key being present in the fourth region 1914 may still preclude session tokens being generated in the fourth region due to the fact that the global session key 1904 is not present in the fourth region 1914.FIG.", "20 illustrates an example process 2000 for distributing an account key to different regions for use in isolating regions using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A security service such as the security service 106 described in connection with FIG.", "1 may perform the process illustrated in FIG.", "20.The security service may first receive 2002 a request for a session and may verify 2004 that request as described above.", "A request that is not valid 2006 may cause the security service to generate an error 2014 in response to the invalid request.", "The security service may generate an error 2014 and send a report of the error to the customer and/or to the computing resource service provider as described above in connection with FIG.", "5.A request that is valid 2006 may cause the security service verify 2008 the region by determining if the region is an untrusted region 2010 (i.e., a region not trusted by the computing resource service provider) and/or if the region is a restricted region 2012 (i.e., a region not trusted by the customer).", "A region may be determined to be an untrusted region 2010 because, for example, there are policies and/or permissions explicitly stating such or because, for example, the global session key is not present in the region.", "Similarly, a region may be determined to be a restricted region 2012 because, for example, there are policies and/or permissions explicitly stating such or because, for example, the account key is not present in the region.", "If the region is an untrusted region 2010 and/or if the region is a restricted region 2012, the security service may generate an error 2014 and send a report of the error to the customer and/or to the computing resource service provider.", "Conversely, if the region is not an untrusted region 2010 and if the region is not a restricted region 2012, the security service may use the global session key and the account key to generate 2016 a session token as described above.", "FIG.", "21 illustrates an example environment 2100 where global session keys are combined with account keys to generate session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "An account key 2102 may be combined with a first global session key 2104 to produce a first session encryption key 2106, which may be used to encrypt 2108 session data to produce a first session token 2110 as described above.", "In an embodiment, the first session encryption key 2106 is generated on demand when the session token is requested.", "In another embodiment, the first session encryption key 2106 is generated in response to a request such as, for example, a first request for a session token and is stored by a service such as the security service for later use (e.g., for later decryption of the session token).", "In another embodiment, the account key 2102 and the first global session key 2104 are used to encrypt 2108 the session data directly, without producing an intermediary first session encryption key such as the first session encryption key 2106.In another embodiment, the account key 2102 and/or the first global session key 2104 are discarded after a period of time, or a number of uses, or according to some other security policy.", "In the example illustrated in FIG.", "21, the first global session key 2104 may be valid only for a predetermined amount of time and, after that predetermined amount of time has expired and a timeout 2112 occurs, a second global session key 2114 may be generated, which may be combined with the account key 2102 to produce a second session encryption key 2116.The second session encryption key 2116 may then be used to encrypt 2118 session data to produce a second session token 2120 as described above.", "Although not illustrated in FIG.", "21, the second global session key 2114 may also be generated as a result of a key generation event that may be generated by the computing resource service provider or a service operating therein.", "A key generation event may be a key rotation event, a key timeout event, a key invalidation event, a keychain update event, or some other key generation event.", "An example of a key generation event is a key rotation event, where on a periodic basis (e.g., hourly) the oldest key (based on a creation time associated with the key) is removed or invalidated and a new key (with a new creation time) is generated.", "Another example of a key generation event is a keychain update event, where one or more keys in a keychain are updated according to one or more update criteria.", "A key generation event may be generated by a security service, causing a global session key such as the first global session key 2104 to be replaced with a new global session key when a region is compromised and/or potentially compromised.", "Similarly, a key generation event may be generated by a policy service, causing a global session key such as the first global session key 2104 to be replaced with a new global session key when one or more policies regarding access to a region have changed.", "In an embodiment, the removal and/or replacement of a global session key causes the session tokens encrypted with that session key to be invalidated.", "In another embodiment, a global session key that is removed and/or replaced remains available for some time in order to extract session data from session tokens encrypted with that global session key.", "FIG.", "22 illustrates an example environment 2200 where global session keys are combined with account keys to generate session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A first account key 2202 may be combined with a global session key 2204 to produce a first session encryption key 2206, which may be used to encrypt 2208 session data to produce a first session token 2210 as described above.", "Just as with the first global session key 2104 described in connection with FIG.", "21, the first account key 2202 may be valid only for a predetermined amount of time and, after that predetermined amount of time has expired and a timeout 2212 occurs, a second account key 2214 may be generated, which may be combined with the global session key 2204 to produce a second session encryption key 2216.The second session encryption key 2216 may then be used to encrypt 2218 session data to produce a second session token 2220 as described above.", "It should be noted that while the timeout 2112 described in connection with FIG.", "21 may be on the order of several hours (e.g., twelve, twenty-four, or thirty-six hours), the timeout 2212 may be on the order of several months (e.g., two, three, or six months).", "The longer timeout 2212 associated with an account key as compared to the timeout 2112 associated with a global session key may be based at least in part on there being only a few global session keys that are valid at one time (e.g., keys for the last twenty-four or thirty-six hours) while there may be millions of account keys when, for example, each user account of a computing resource service provider has a different unique account key.", "Because there may be many more account keys in a computing resource service provider environment, they may be used for longer periods of time than global session keys.", "FIG.", "23 illustrates an example environment 2300 where global session keys are maintained for use in generating session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "In the example illustrated in FIG.", "23, a global session keychain 2302 stores a plurality of global session keys, one of which is the oldest 2304 global session key (i.e., the global session key that was generated least recently) and one of which is the newest 2306 global session key (i.e., the global session key that was generated the most recently).", "When a key generation event such as a timeout 2308 occurs, the global session keychain 2302 may be updated by, for example, invalidating 2310 the oldest 2304 global session key designating the next oldest global session key 2312 as the new oldest 2314 global session key, generating 2318 a new global session key, designating that new global session key as the newest 2320 global session key, and changing the designation of the former newest global session key 2316.In an embodiment, only the newest global session key is used to encrypt session tokens and the other global session keys in the global session keychain are used to decrypt session tokens.", "In such an embodiment, using the example illustrated in FIG.", "23, a session token is encrypted using the newest 2306 global session key immediately before the timeout 2308 and is encrypted using the newest 2320 global session immediately after the timeout 2308 (and, until the next key generation event occurs).", "FIG.", "24 illustrates an example environment 2400 where sessions are expired using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A customer 2402 may first generate a signed request 2404 using a session token as described herein.", "In the example illustrated in FIG.", "24, the session token used to generate the signed request 2404 was generated using a session encryption key 2414, which may be one of a plurality of session encryption keys 2408.In an embodiment, the session encryption keys 2408 and the session encryption key 2414 are generated using a global session key and an account key as described at least in connection with FIG.", "18.The signed request 2404 may be verified 2410 by a service 2406 (e.g., a security service such as the security service 106 described in connection with FIG.", "1) and the signed request may be processed 2412 because the session encryption key 2414 is still valid and is still one of the plurality of session encryption keys 2408.Conversely, after one or more key generation events such as a timeout 2416, the session encryption key 2414 may become an invalid session encryption key 2430, and may be replaced by one or more new session encryption keys in the plurality of session encryption keys 2428.For example, if a new session encryption key is generated every hour, and each session encryption key is valid for twenty-four hours, then there may be twenty-four session encryption keys in the plurality of session encryption keys 2428.In such an example, after twenty-four hours pass, the first session token used to generate the signed request 2404 may no longer be valid due to the session encryption key 2414 having expired.", "In the example illustrated in FIG.", "24, if the customer 2418 uses the session token generated using the session encryption key 2414 to generate a signed request 2420 after the session encryption key 2414 has expired and become the invalid session encryption key 2430, the service 2422 may not be able to verify 2424 the signed request 2420 (because, for example, the session token may not be decrypted) and, accordingly, the service 2422 may not process the request 2426.FIG.", "25 illustrates an example process 2500 for rotating session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A security service such as the security service 106 described in connection with FIG.", "1 may perform the process illustrated in FIG.", "25.The security service may first generate 2502 the session encryption key from the global session key and the account key as described at least in connection with FIG.", "18.If after a time period has expired and/or after a key generation event has occurred, the security service may generate new session encryption keys.", "For example, if a session encryption key expires or becomes invalid because of a global key timeout 2504, the security service may generate 2508 one or more replacement session encryption keys.", "Similarly, if a session encryption key expires or becomes invalid because of an account key timeout 2506, the security service may also generate 2508 one or more replacement session encryption keys.", "The security service may next receive 2510 one or more signed requests using session tokens encrypted with the one or more session encryption keys as described above.", "It should be noted that, although the process illustrated in FIG.", "25 shows the security service receiving the signed requests after a time period has expired and/or after a key generation event has occurred, the security service may generate new session encryption keys, the steps in the process to respond to a global key timeout 2504 and/or an account key timeout 2506 as well as to generate 2508 one or more replacement session encryption keys may occur before, during, or after the steps in the process to receive 2510 one or more signed requests using session tokens encrypted with the one or more session encryption keys.", "After receiving the one or more signed requests, the security service may verify the session using a session encryption key corresponding to the session encryption key that was used to encrypt the session token associated with the signed request as described herein.", "If the session is verified (i.e., if the session token is validated), then the security service may process the request 2516.Conversely, if the session is not verified, the security service may generate an error 2518 as described above.", "FIG.", "26 illustrates an example environment 2600 where a plurality of session keys can be invalidated using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "In the example illustrated in FIG.", "26, a global session key 2602 may be combined with account keys 2604 to generate session encryption keys 2606 as described above.", "The session encryption keys 2606 may remain valid and the session tokens generated using the session encryption keys 2606 may also remain valid for a time period.", "When the time period has expired, the global session key 2602 may be invalidated 2608 and may become an invalid global session key 2610.As a result of the global session key 2602 becoming an invalid global session key 2610, the session encryption keys generated from the invalid global session key 2610 and the account keys 2604 may become invalid session encryption keys 2612 and session tokens generate using the formerly valid, but now invalid, session encryption keys such as the invalid session encryption keys 2612 may also become invalid due to being unverifiable.", "FIG.", "27 illustrates an example environment 2700 where a plurality of invalidated session keys can be regenerated using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "The example illustrated in FIG.", "27 continues from the example illustrated in FIG.", "26, where a global session key is an invalid global session key 2704 and, as a result, the session encryption keys generated from the invalid global session key 2704 and the account keys 2702 are invalid session encryption keys 2706.After the global session key has become an invalid global session key 2704, the security service may generate 2708 a new global session key 2710 to replace the invalid global session key 2704 and may use the new global session key 2710 combined with the account keys 2702 to generate 2712 session encryption keys 2714 as needed.", "It should be noted that, in the examples illustrated in FIGS.", "26 and 27, the account keys were not changed.", "As described above, an account may have a much longer period of validity than a global session key.", "Additionally, a computing resource service provider may provide thousands or millions of account keys and, accordingly, it may be considerably more efficient to regenerate session encryption keys by invalidating global session keys.", "It should also be noted that session encryption keys may be generated as needed within a computing resource service provider environment.", "For example, a customer may use a user account to request a session token as described herein and may use that session token for a short period of time (e.g., two hours).", "Because of the expiration of global session keys, that session token may expire after, for example, twenty-four hours.", "If the customer does not use the session token again in that twenty-four hour period, the session encryption key used to generate the session token and corresponding to the account key for the user account may not be regenerated at the end of that twenty-four hour period (e.g., as a replacement for the expired or invalidated session encryption key).", "In an embodiment, the session encryption key used to generate session tokens corresponding to a user account is generated only when the customer generates a signed request using the previous session token.", "In such an embodiment, a session token may include an expiration time that may trigger such a regeneration of the session token.", "FIG.", "28 illustrates an example process 2800 for invalidating and regenerating a plurality of session keys using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A security service such as the security service 106 described in connection with FIG.", "1 may perform the process illustrated in FIG.", "28.The security service may first generate 2802 session encryption keys using the global session key and the account keys as described above.", "The security service may next determine whether to invalidate 2804 one or more global session keys.", "If the security service does determine to invalidate 2804 one or more global session keys, the security service may first invalidate 2806 the selected global session key or keys, may generate 2808 one or more new global session keys to replace the invalidated global session keys and may begin the process of generating replacement session encryption keys as needed such as, for example, when a customer generates a request using a session token that was generated with a now invalid session encryption key as described above.", "The security service may next receive 2812 a request for resources or a message as described above.", "It should be noted that, although the process illustrated in FIG.", "28 shows the security service receiving a signed request or message after checking for invalidated global keys, the checking for invalidated global keys may be performed before, during, or after the processing of the requests.", "The request for resources or the message may be digitally signed by a session key and may also be generated using a session token, also as described above.", "Next, the security service may extract 2814 the session key from the session token used to generate the session token and may validate 2816 the digital signature.", "If the signature is valid 2818 (i.e., if the request or the message is authenticated), the security service may next process 2810 the request or the message by, for example, providing access to the resources, processing the message, or performing some other action.", "If the signature is not valid 2818 (i.e., if the request or the message is not authenticated) the security service may generate 2822 an error as described above.", "FIG.", "29 illustrates an example environment 2900 where account keys are invalidated in association with session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "In the example illustrated in FIG.", "29, a global session key 2904 may be used with one or more account keys 2902 to generate a corresponding one or more session encryption keys 2908 as described above.", "A security service may then invalidate 2908 one or more of the account keys 2910 to invalidate one or more session encryption keys 2914 generated with the account keys 2910 and a global session key 2912.In contrast to the example illustrated in FIGS.", "26 and 27 where all session encryption keys were invalidated by invalidating the global session key, the example illustrated in FIG.", "29 shows the selecting invalidation of session encryption keys and, accordingly, of session tokens generated using those invalidated session encryption keys.", "For example, a computing resource service provider may determine that one or more accounts associated with a customer may have been compromised.", "Invalidating the account keys associated with those compromised accounts renders the credentials associated with those accounts (e.g., the session tokens) invalid.", "Similarly, a customer may determine that one or more user accounts should not have access to short-term credentials and may invalidate the account keys associated with those accounts.", "FIG.", "30 illustrates an example environment 3000 where cross-region roles are assumed across regions using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A first customer 3002 in a first region 3006 may create 3004 a role.", "The role 3008 may have a role identifier 3014 (illustrated herein as a circle with the letters “ID” inside) and a set of permissions 3010 for access to a set of customer resources 3012 in the first region.", "The customer resources 3012 are a set of resources associated with the first customer 3002.For example, a customer may have a resource such as a database that is configured to store data associated with a webservice (e.g., a database that records each transaction for each user of the webservice).", "The customer may create first role for this database that provides permissions to read, but not write, data from the database.", "The customer may additionally create a second role for this database that provides permissions to read and write data to and from the database.", "The customer may additionally create a third role for this database that provides permissions to alter the database, including adding and removing records and changing the data schema (e.g., an “administrator” role).", "A user of a user account may then assume one or more of these roles to have access to the database.", "For example, a user may assume the first role if the user only requires permission to read data from the database.", "Using the first role, the user could analyze, but not alter, the data in the database.", "Similarly, a user may assume the second role if the user requires permissions to read from and write to the database.", "Using the second role, the user could update records in the database.", "The third role could be assumed to allow the user to alter the structure of the database to, for example, add a new table to the database schema.", "Each of the roles may have a set of permissions associated with access to the resources and may also have a set of access policies associated with the role so that, for example, only designated users and/or user accounts may have access to the role.", "These access policies may be enforced using credentials such as those described herein (e.g., keys, sessions, etc.).", "The access policies and the permissions associated with the roles are described in more detail below.", "The role identifier 3014 may be used to identify the role in other regions.", "For example, the role 3008 may be propagated to a second region 3022 (where it is identified as the role 3020) and may also be propagated to a third region 3030 (where it is identified as the role 3024).", "In an embodiment, a role can only be assumed in regions where the role has been propagated because regions where the role has not been propagated may not have access to the permissions associated with the role.", "In the example illustrated in FIG.", "30, the role has access to customer resources 3012 in the first region 3006 and customer resources 3028 in the third region 3030.The role 3024, which is the same as the role 3014, may have a set of permissions 3026 for access to a set of customer resources 3028 in the third region.", "The set of customer resources 3028 are a set of resources associated with the first customer 3002, but present in the third region.", "In the example illustrated in FIG.", "30, no customer resources associated with the first customer 3002 are present in the second region 3022.When a second customer 3016 in the second region 3022 assumes the role 3018 based at least in part on the role identifier 3014, the access policies associated with the role determine whether the second customer 3016 may assume the role.", "If the second customer 3016 assumes the role 3018, the second customer 3016 may have all of the permissions associated with the role so that, for example, the second customer 3016 may access the customer resources 3012 in the first region 3006 and may also access the customer resources 3028 in the third region 3030.It should be noted that the second customer 3016 does not have an account in the first region 3006 or in the third region 3030, but still may be authenticated to assume the role and access the resources by assuming the role.", "In the example illustrated in FIG.", "30, the role identifier 3014 is provided to the second customer 3016 in the second region 3022 so that the second customer 3016 in the second region may assume the role.", "In an embodiment, the role identifier is provided to the second customer by storing the role in a database of role identifiers.", "In another embodiment, the role identifier is provided to the second customer by sending the role identifier in an email, or a SMS message, or a console message, or using some other such communications methodology.", "In such an embodiment, the role identifier may be sent using an encryption method such as those described herein.", "In another embodiment, the role identifier is provided to the second customer by publishing the role identifier in documentation associated with the customer resources 3028.For example, the customer resources 3028 may have a webpage documenting the use of the resources that may include the role identifier to use when requesting access to the resources.", "As may be contemplated, the methods of providing the role identifier described herein are illustrative examples and other such methods of providing the role identifier may be considered as within the scope of the present disclosure.", "FIG.", "31 illustrates an example environment 3100 where policies associated with cross-region roles are applied using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "The role 3102 has a role identifier 3104, an allowed users policy 3106, and one or more allowed resources policies 3114.In the example illustrated in FIG.", "31, the allowed users policy 3106 indicates that a first user 3108 may assume the role 3102, a second user 3110 may also assume the role 3102, and a third user 3112 may not assume the role 3102.The third user 3112 may be, for example, an untrusted user or may simply be associated with an account that should not have access to the permissions associated with the role.", "The allowed users policy 3106 may include a default policy to deny all users not explicitly allowed by the policy so that only users explicitly granted access to the role may assume the role.", "In the example illustrated in FIG.", "31, the allowed resources policies 3114 specify a set of permissions for access to a set of resources associated with the role.", "The permissions may be specific to, and based at least in part on, a region, a user, a resource, a resource type, or a combination of these and/or other such factors.", "For example, a set of permissions 3116 for a resource 3118 may specify that users from, for example, a first region may have unrestricted access to the resource 3118 and users from, for example, a second region may have restricted access to the resource 3118.Similarly, a set of permissions 3120 for a resource 3122 may specify that the role 3102 as assumed by the first user 3108 has different access permissions than the role 3102 as assumed by the second user 3110.As may be contemplated, the types of permissions granted by assuming a role described herein are merely illustrative examples and other types of permissions granted by assuming a role may be considered as within the scope of the present disclosure.", "FIG.", "32 illustrates an example environment 3200 where a cross-region role is assumed using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A second customer 3202, which may be the same as the second customer 3016 described in connection with FIG.", "30, may send a signed request 3204 to assume a role 3206 to a security service 3208 of a second region 3220, which may be the same as the second region 3022 described in connection with FIG.", "30.The security service 3208 of the second region 3220 may first verify that the role 3214 exists in the second region 3220 before verifying the request 3204, verifying that the second customer 3202 has permission to assume the role 3214, and validating the signature of the signed request 3204.If the signed request 3204 is valid (i.e., if all of the verifications pass), the security service may generate a session associated with the role (designated herein as a role session 3212) using the methods described above.", "In an embodiment, the security service 3208 includes the role identifier in the session data prior to encrypting the session data to produce the session token as described above.", "In another embodiment, the security service 3208 provides the role identifier separate from the session token.", "In the example illustrated in FIG.", "32, the role 3214 provides access 3216 to customer resources 3218 in a third region 3222, but the second customer 3202 does not have an account in the third region 3222.Access to the customer resources 3218 are provided to the second customer 3202 using the mechanism of the second customer 3202 assuming the role 3214.FIG.", "33 illustrates an example environment 3300 where a cross-region role is used to access resources across regions using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A customer 3302 may use a role session 3304 to generate a signed request 3308 and send 3306 the signed request to a region 3310 where the resources 3324 are located.", "A service of the region 3310 may verify 3312 the session using the techniques described herein and may validate 3314 that the customer 3302 may have access to the role 3318 based at least in part on the permissions associated with the role 3318.If the session is verified and the access is validated, access 3320 to the resources 3324 may be provided to the customer 3302 using the access 3322 to the resources 3324 provided by the role 3318.In the example illustrated in FIG.", "33, the role session 3304 provides the credentials associated with assuming the role 3318 using the short-term credentials provided by the session token.", "In an embodiment, the credentials associated with assuming the role 3318 are provided by a username and password associated with the customer 3302.In another embodiment, the credentials associated with assuming the role 3318 are provided by a certificate associated with the customer 3302.In another embodiment, the credentials associated with assuming the role 3318 are provided by a long-term key associated with the customer 3302.In such an embodiment, the credentials associated with assuming the role 3318 may be a symmetric key or may be an asymmetric key pair.", "FIG.", "34 illustrates an example process 3400 for using a cross-region role session token to generate resource requests using session credentials as described in connection with FIG.", "1 and in accordance with an embodiment.", "A security service such as the security service 106 described in connection with FIG.", "1 may perform the process illustrated in FIG.", "34.The security service may first receive 3402 a request for resources signed by a session key and using a role session token as described above.", "The request for resources may be digitally signed by a session key, may be generated using a session token, and may include a role identifier, also as described above.", "Next, the security service may extract 3404 the session key from the session token used to generate the session token and may verify 3406 the digital signature using the extracted session key.", "If the request is valid 3408 (i.e., if the request is authenticated), the security service may next determine 3410 whether the permissions associated with the request allow such access.", "If the access is allowed 3412, the service may provide 3416 access to the resources using the role.", "If the request is not valid 3408 or if the access is not allowed 3412, the security service may generate 3414 an error as described above.", "FIG.", "35 illustrates aspects of an example environment 3500 for implementing aspects in accordance with various embodiments.", "As will be appreciated, although a web-based environment is used for purposes of explanation, different environments may be used, as appropriate, to implement various embodiments.", "The environment includes an electronic client device 3502, which can include any appropriate device operable to send and/or receive requests, messages, or information over an appropriate network 3504 and, in some embodiments, convey information back to a user of the device.", "Examples of such client devices include personal computers, cell phones, handheld messaging devices, laptop computers, tablet computers, set-top boxes, personal data assistants, embedded computer systems, electronic book readers, and the like.", "The network can include any appropriate network, including an intranet, the Internet, a cellular network, a local area network, a satellite network or any other such network and/or combination thereof.", "Components used for such a system can depend at least in part upon the type of network and/or environment selected.", "Many protocols and components for communicating via such a network are well known and will not be discussed herein in detail.", "Communication over the network can be enabled by wired or wireless connections and combinations thereof.", "In this example, the network includes the Internet and/or other publicly-addressable communications network, as the environment includes a web server 3506 for receiving requests and serving content in response thereto, although for other networks an alternative device serving a similar purpose could be used as would be apparent to one of ordinary skill in the art.", "The illustrative environment includes at least one application server 3508 and a data store 3510.It should be understood that there can be several application servers, layers or other elements, processes or components, which may be chained or otherwise configured, which can interact to perform tasks such as obtaining data from an appropriate data store.", "Servers, as used herein, may be implemented in various ways, such as hardware devices or virtual computer systems.", "In some contexts, servers may refer to a programming module being executed on a computer system.", "As used herein, unless otherwise stated or clear from context, the term “data store” refers to any device or combination of devices capable of storing, accessing and retrieving data, which may include any combination and number of data servers, databases, data storage devices and data storage media, in any standard, distributed, virtual or clustered environment.", "The application server can include any appropriate hardware, software and firmware for integrating with the data store as needed to execute aspects of one or more applications for the client device, handling some or all of the data access and business logic for an application.", "The application server may provide access control services in cooperation with the data store and is able to generate content including, but not limited to, text, graphics, audio, video and/or other content usable to be provided to the user, which may be served to the user by the web server in the form of HyperText Markup Language (“HTML”), Extensible Markup Language (“XML”), JavaScript, Cascading Style Sheets (“C SS”), JavaScript Object Notation (JSON), and/or another appropriate client-side structured language.", "Content transferred to a client device may be processed by the client device to provide the content in one or more forms including, but not limited to, forms that are perceptible to the user audibly, visually and/or through other senses.", "The handling of all requests and responses, as well as the delivery of content between the client device 3502 and the application server 3508, can be handled by the web server using PHP: Hypertext Preprocessor (“PHP”), Python, Ruby, Perl, Java, HTML, XML, JSON, and/or another appropriate server-side structured language in this example.", "Further, operations described herein as being performed by a single device may, unless otherwise clear from context, be performed collectively by multiple devices, which may form a distributed and/or virtual system.", "The data store 3510 can include several separate data tables, databases, data documents, dynamic data storage schemes and/or other data storage mechanisms and media for storing data relating to a particular aspect of the present disclosure.", "For example, the data store illustrated may include mechanisms for storing production data 3512 and user information 3516, which can be used to serve content for the production side.", "The data store also is shown to include a mechanism for storing log data 3514, which can be used for reporting, analysis, or other such purposes.", "It should be understood that there can be many other aspects that may need to be stored in the data store, such as page image information and access rights information, which can be stored in any of the above listed mechanisms as appropriate or in additional mechanisms in the data store 3510.The data store 3510 is operable, through logic associated therewith, to receive instructions from the application server 3508 and obtain, update or otherwise process data in response thereto.", "The application server 3508 may provide static, dynamic, or a combination of static and dynamic data in response to the received instructions.", "Dynamic data, such as data used in web logs (blogs), shopping applications, news services, and other such applications may be generated by server-side structured languages as described herein or may be provided by a content management system (“CMS”) operating on, or under the control of, the application server.", "In one example, a user, through a device operated by the user, might submit a search request for a certain type of item.", "In this case, the data store might access the user information to verify the identity of the user and can access the catalog detail information to obtain information about items of that type.", "The information then can be returned to the user, such as in a results listing on a web page that the user is able to view via a browser on the user device 3502.Information for a particular item of interest can be viewed in a dedicated page or window of the browser.", "It should be noted, however, that embodiments of the present disclosure are not necessarily limited to the context of web pages, but may be more generally applicable to processing requests in general, where the requests are not necessarily requests for content.", "Each server typically will include an operating system that provides executable program instructions for the general administration and operation of that server and typically will include a computer-readable storage medium (e.g., a hard disk, random access memory, read only memory, etc.)", "storing instructions that, when executed (i.e., as a result of being executed) by a processor of the server, allow the server to perform its intended functions.", "The environment, in one embodiment, is a distributed and/or virtual computing environment utilizing several computer systems and components that are interconnected via communication links, using one or more computer networks or direct connections.", "However, it will be appreciated by those of ordinary skill in the art that such a system could operate equally well in a system having fewer or a greater number of components than are illustrated in FIG.", "35.Thus, the depiction of the system 3500 in FIG.", "35 should be taken as being illustrative in nature and not limiting to the scope of the disclosure.", "The various embodiments further can be implemented in a wide variety of operating environments, which in some cases can include one or more user computers, computing devices or processing devices which can be used to operate any of a number of applications.", "User or client devices can include any of a number of computers, such as desktop, laptop or tablet computers running a standard operating system, as well as cellular, wireless and handheld devices running mobile software and capable of supporting a number of networking and messaging protocols.", "Such a system also can include a number of workstations running any of a variety of commercially-available operating systems and other known applications for purposes such as development and database management.", "These devices also can include other electronic devices, such as dummy terminals, thin-clients, gaming systems and other devices capable of communicating via a network.", "These devices also can include virtual devices such as virtual machines, hypervisors and other virtual devices capable of communicating via a network.", "Various embodiments of the present disclosure utilize at least one network that would be familiar to those skilled in the art for supporting communications using any of a variety of commercially-available protocols, such as Transmission Control Protocol/Internet Protocol (“TCP/IP”), User Datagram Protocol (“UDP”), protocols operating in various layers of the Open System Interconnection (“OSI”) model, File Transfer Protocol (“FTP”), Universal Plug and Play (“UpnP”), Network File System (“NFS”), Common Internet File System (“CIFS”), and AppleTalk.", "The network can be, for example, a local area network, a wide-area network, a virtual private network, the Internet, an intranet, an extranet, a public switched telephone network, an infrared network, a wireless network, a satellite network, and any combination thereof.", "In some embodiments, connection-oriented protocols may be used to communicate between network endpoints.", "Connection-oriented protocols (sometimes called connection-based protocols) are capable of transmitting data in an ordered stream.", "Connection-oriented protocols can be reliable or unreliable.", "For example, the TCP protocol is a reliable connection-oriented protocol.", "Asynchronous Transfer Mode (“ATM”) and Frame Relay are unreliable connection-oriented protocols.", "Connection-oriented protocols are in contrast to packet-oriented protocols such as UDP that transmit packets without a guaranteed ordering.", "In embodiments utilizing a web server, the web server can run any of a variety of server or mid-tier applications, including Hypertext Transfer Protocol (“HTTP”) servers, FTP servers, Common Gateway Interface (“CGP”) servers, data servers, Java servers, Apache servers, and business application servers.", "The server(s) also may be capable of executing programs or scripts in response to requests from user devices, such as by executing one or more web applications that may be implemented as one or more scripts or programs written in any programming language, such as Java®, C, C#, or C++, or any scripting language, such as Ruby, PHP, Perl, Python or TCL, as well as combinations thereof.", "The server(s) may also include database servers, including without limitation those commercially available from Oracle®, Microsoft®, Sybase®, and IBM® as well as open-source servers such as MySQL, Postgres, SQLite, MongoDB, and any other server capable of storing, retrieving, and accessing structured or unstructured data.", "Database servers may include table-based servers, document-based servers, unstructured servers, relational servers, non-relational servers, or combinations of these and/or other database servers.", "The environment can include a variety of data stores and other memory and storage media as discussed above.", "These can reside in a variety of locations, such as on a storage medium local to (and/or resident in) one or more of the computers or remote from any or all of the computers across the network.", "In a particular set of embodiments, the information may reside in a storage-area network (“SAN”) familiar to those skilled in the art.", "Similarly, any necessary files for performing the functions attributed to the computers, servers or other network devices may be stored locally and/or remotely, as appropriate.", "Where a system includes computerized devices, each such device can include hardware elements that may be electrically coupled via a bus, the elements including, for example, at least one central processing unit (“CPU” or “processor”), at least one input device (e.g., a mouse, keyboard, controller, touch screen, or keypad) and at least one output device (e.g., a display device, printer, or speaker).", "Such a system may also include one or more storage devices, such as disk drives, optical storage devices, and solid-state storage devices such as random access memory (“RAM”) or read-only memory (“ROM”), as well as removable media devices, memory cards, flash cards, etc.", "Such devices also can include a computer-readable storage media reader, a communications device (e.g., a modem, a network card (wireless or wired), an infrared communication device, etc.", "), and working memory as described above.", "The computer-readable storage media reader can be connected with, or configured to receive, a computer-readable storage medium, representing remote, local, fixed, and/or removable storage devices as well as storage media for temporarily and/or more permanently containing, storing, transmitting, and retrieving computer-readable information.", "The system and various devices also typically will include a number of software applications, modules, services, or other elements located within at least one working memory device, including an operating system and application programs, such as a client application or web browser.", "In addition, customized hardware might also be used and/or particular elements might be implemented in hardware, software (including portable software, such as applets) or both.", "Further, connection to other computing devices such as network input/output devices may be employed.", "Storage media and computer readable media for containing code, or portions of code, can include any appropriate media known or used in the art, including storage media and communication media, such as, but not limited to, volatile and non-volatile, removable and non-removable media implemented in any method or technology for storage and/or transmission of information such as computer readable instructions, data structures, program modules or other data, including RAM, ROM, Electrically Erasable Programmable Read-Only Memory (“EEPROM”), flash memory or other memory technology, Compact Disc Read-Only Memory (“CD-ROM”), digital versatile disk (DVD) or other optical storage, magnetic cassettes, magnetic tape, magnetic disk storage or other magnetic storage devices or any other medium which can be used to store the desired information and which can be accessed by the system device.", "Based on the disclosure and teachings provided herein, a person of ordinary skill in the art will appreciate other ways and/or methods to implement the various embodiments.", "The specification and drawings are, accordingly, to be regarded in an illustrative rather than a restrictive sense.", "It will, however, be evident that various modifications and changes may be made thereunto without departing from the broader spirit and scope of the invention as set forth in the claims.", "Other variations are within the spirit of the present disclosure.", "Thus, while the disclosed techniques are susceptible to various modifications and alternative constructions, certain illustrated embodiments thereof are shown in the drawings and have been described above in detail.", "It should be understood, however, that there is no intention to limit the invention to the specific form or forms disclosed, but on the contrary, the intention is to cover all modifications, alternative constructions, and equivalents falling within the spirit and scope of the invention, as defined in the appended claims.", "The use of the terms “a” and “an” and “the” and similar referents in the context of describing the disclosed embodiments (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context.", "The terms “comprising,” “having,” “including,” and “containing” are to be construed as open-ended terms (i.e., meaning “including, but not limited to,”) unless otherwise noted.", "The term “connected,” when unmodified and referring to physical connections, is to be construed as partly or wholly contained within, attached to, or joined together, even if there is something intervening.", "Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein and each separate value is incorporated into the specification as if it were individually recited herein.", "The use of the term “set” (e.g., “a set of items”) or “subset” unless otherwise noted or contradicted by context, is to be construed as a nonempty collection comprising one or more members.", "Further, unless otherwise noted or contradicted by context, the term “subset” of a corresponding set does not necessarily denote a proper subset of the corresponding set, but the subset and the corresponding set may be equal.", "Conjunctive language, such as phrases of the form “at least one of A, B, and C,” or “at least one of A, B and C,” unless specifically stated otherwise or otherwise clearly contradicted by context, is otherwise understood with the context as used in general to present that an item, term, etc., may be either A or B or C, or any nonempty subset of the set of A and B and C. For instance, in the illustrative example of a set having three members, the conjunctive phrases “at least one of A, B, and C” and “at least one of A, B and C” refer to any of the following sets: {A}, {B}, {C}, {A, B}, {A, C}, {B, C}, {A, B, C}.", "Thus, such conjunctive language is not generally intended to imply that certain embodiments require at least one of A, at least one of B and at least one of C each to be present.", "Operations of processes described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context.", "Processes described herein (or variations and/or combinations thereof) may be performed under the control of one or more computer systems configured with executable instructions and may be implemented as code (e.g., executable instructions, one or more computer programs or one or more applications) executing collectively on one or more processors, by hardware or combinations thereof.", "The code may be stored on a computer-readable storage medium, for example, in the form of a computer program comprising a plurality of instructions executable by one or more processors.", "The computer-readable storage medium may be non-transitory.", "In some embodiments, the code is stored on set of one or more non-transitory computer-readable storage media having stored thereon executable instructions that, when executed (i.e., as a result of being executed) by one or more processors of a computer system, cause the computer system to perform operations described herein.", "The set of non-transitory computer-readable storage media may comprise multiple non-transitory computer-readable storage media and one or more of individual non-transitory storage media of the multiple non-transitory computer-readable storage media may lack all of the code while the multiple non-transitory computer-readable storage media collectively store all of the code.", "Accordingly, in some examples, computer systems are configured to implement one or more services that singly or collectively perform operations of processes described herein.", "Such computer systems may, for instance, be configured with applicable hardware and/or software that enable the performance of the operations.", "Further, computer systems that implement various embodiments of the present disclosure may, in some examples, be single devices and, in other examples, be distributed computer systems comprising multiple devices that operate differently such that the distributed computer system performs the operations described herein and such that a single device may not perform all operations.", "The use of any and all examples, or exemplary language (e.g., “such as”) provided herein, is intended merely to better illuminate embodiments of the invention and does not pose a limitation on the scope of the invention unless otherwise claimed.", "No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the invention.", "Embodiments of this disclosure are described herein, including the best mode known to the inventors for carrying out the invention.", "Variations of those embodiments may become apparent to those of ordinary skill in the art upon reading the foregoing description.", "The inventors expect skilled artisans to employ such variations as appropriate and the inventors intend for embodiments of the present disclosure to be practiced otherwise than as specifically described herein.", "Accordingly, the scope of the present disclosure includes all modifications and equivalents of the subject matter recited in the claims appended hereto as permitted by applicable law.", "Moreover, any combination of the above-described elements in all possible variations thereof is encompassed by the scope of the present disclosure unless otherwise indicated herein or otherwise clearly contradicted by context.", "All references, including publications, patent applications, and patents, cited herein are hereby incorporated by reference to the same extent as if each reference were individually and specifically indicated to be incorporated by reference and were set forth in its entirety herein." ] ]
Patent_15875995
[ [ "PROVIDING PRE-COMPUTED HOTWORD MODELS", "Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for obtaining, for each of multiple words or sub-words, audio data corresponding to multiple users speaking the word or sub-word; training, for each of the multiple words or sub-words, a pre-computed hotword model for the word or sub-word based on the audio data for the word or sub-word; receiving a candidate hotword from a computing device; identifying one or more pre-computed hotword models that correspond to the candidate hotword; and providing the identified, pre-computed hotword models to the computing device." ], [ "1.", "(canceled) 2.A computer-implemented method comprising: receiving, by a server-based hotword configuration engine, text that a user has typed or entered by touch input into a mobile computing device or digital assistant device for use as a custom hotword, wherein a custom hotword is personalized term that, when spoken in advance of a voice command, initiates a wake up process on the mobile computing device or digital assistant device for processing the voice command; obtaining, by the server-based hotword configuration engine, a hotword detection model that was previously trained to detect the custom hotword being spoken without using any audio samples of the user speaking the custom hotword; and providing, by the server-based hotword configuration engine, the hotword detection model to the mobile computing device or the digital assistant device for use in detecting the custom hotword being spoken by the user.", "3.The method of claim 2, wherein the text is typed or entered into the mobile computing device or digital assistant device in response to a prompt.", "4.The method of claim 2, wherein the text comprises two or more words.", "5.The method of claim 2, wherein the hotword detection model is trained based on portions of audio samples of other users speaking other words that are not the custom hotword.", "6.The method of claim 2, wherein the hotword detection model comprises a pre-computed model that was already stored in a vocabulary database when the text was typed or entered.", "7.The method of claim 2, comprising receiving and processing a voice command that (i) was preceded by the custom hotword in an utterance that was received by the mobile computing device or the digital assistant device, and (ii) was received after the hotword detection model was provided to the mobile computing device or the digital assistant device.", "8.A system comprising: one or more computers; and a non-transitory computer-readable medium coupled to the one or more computers having instructions stored thereon which, when executed by the one or more computers, cause the one or more computers to perform operations comprising: receiving, by a server-based hotword configuration engine, text that a user has typed or entered by touch input into a mobile computing device or digital assistant device for use as a custom hotword, wherein a custom hotword is personalized term that, when spoken in advance of a voice command, initiates a wake up process on the mobile computing device or digital assistant device for processing the voice command; obtaining, by the server-based hotword configuration engine, a hotword detection model that was previously trained to detect the custom hotword being spoken without using any audio samples of the user speaking the custom hotword; and providing, by the server-based hotword configuration engine, the hotword detection model to the mobile computing device or the digital assistant device for use in detecting the custom hotword being spoken by the user.", "9.The system of claim 8, wherein the text is typed or entered into the mobile computing device or digital assistant device in response to a prompt.", "10.The system of claim 8, wherein the text comprises two or more words.", "11.The system of claim 8, wherein the hotword detection model is trained based on portions of audio samples of other users speaking other words that are not the custom hotword.", "12.The system of claim 8, wherein the hotword detection model comprises a pre-computed model that was already stored in a vocabulary database when the text was typed or entered.", "13.The system of claim 8, comprising receiving and processing a voice command that (i) was preceded by the custom hotword in an utterance that was received by the mobile computing device or the digital assistant device, and (ii) was received after the hotword detection model was provided to the mobile computing device or the digital assistant device.", "14.A non-transitory computer storage medium encoded with a computer program, the computer program comprising instructions that when executed by one or more processors cause the one or more processors to perform operations comprising: receiving, by a server-based hotword configuration engine, text that a user has typed or entered by touch input into a mobile computing device or digital assistant device for use as a custom hotword, wherein a custom hotword is personalized term that, when spoken in advance of a voice command, initiates a wake up process on the mobile computing device or digital assistant device for processing the voice command; obtaining, by the server-based hotword configuration engine, a hotword detection model that was previously trained to detect the custom hotword being spoken without using any audio samples of the user speaking the custom hotword; and providing, by the server-based hotword configuration engine, the hotword detection model to the mobile computing device or the digital assistant device for use in detecting the custom hotword being spoken by the user.", "15.The medium of claim 14, wherein the text is typed or entered into the mobile computing device or digital assistant device in response to a prompt.", "16.The medium of claim 14, wherein the text comprises two or more words.", "17.The medium of claim 14, wherein the hotword detection model is trained based on portions of audio samples of other users speaking other words that are not the custom hotword.", "18.The medium of claim 14, wherein the hotword detection model comprises a pre-computed model that was already stored in a vocabulary database when the text was typed or entered.", "19.The medium of claim 14, comprising receiving and processing a voice command that (i) was preceded by the custom hotword in an utterance that was received by the mobile computing device or the digital assistant device, and (ii) was received after the hotword detection model was provided to the mobile computing device or the digital assistant device." ], [ "<SOH> BACKGROUND <EOH>The reality of a speech-enabled home or other environment—that is, one in which a user need only speak a query or command out loud and a computer-based system will field and answer the query and/or cause the command to be performed—is upon us.", "A speech-enabled environment (e.g., home, workplace, school, etc.)", "can be implemented using a network of connected microphone devices distributed throughout the various rooms or areas of the environment.", "Through such a network of microphones, a user has the power to orally query the system from essentially anywhere in the environment without the need to have a computer or other device in front of him/her or even nearby.", "For example, while cooking in the kitchen, a user might ask the system “how many milliliters in three cups?” and, in response, receive an answer from the system, e.g., in the form of synthesized voice output.", "Alternatively, a user might ask the system questions such as “when does my nearest gas station close,” or, upon preparing to leave the house, “should I wear a coat today?” Further, a user may ask a query of the system, and/or issue a command, that relates to the user's personal information.", "For example, a user might ask the system “when is my meeting with John?” or command the system “remind me to call John when I get back home.” In a speech-enabled environment, a user's manner of interacting with the system is designed to be primarily, if not exclusively, by means of voice input.", "Consequently, a system which potentially picks up all utterances made in the environment, including those not directed to the system, must have some way of discerning when any given utterance is directed at the system as opposed, e.g., to being directed an individual present in the environment.", "One way to accomplish this is to use a “hotword” (also referred to as an “attention word” or “voice action initiation command”), which by agreement is reserved as a predetermined term that is spoken to invoke the attention of the system.", "In one example environment, the hotword used to invoke the system's attention is the word “Google.” Consequently, each time the word “Google” is spoken, it is picked up by one of the microphones, and is conveyed to the system, which performs speech recognition techniques to determine whether the hotword was spoken and, if so, awaits an ensuing command or query.", "Accordingly, utterances directed at the system take the general form [HOTWORD] [QUERY], where “HOTWORD” in this example is “Google” and “QUERY” can be any question, command, declaration, or other request that can be speech recognized, parsed and acted on by the system, either alone or in conjunction with a server over network." ], [ "<SOH> SUMMARY <EOH>According to some innovative aspects of the subject matter described in this specification, a system can provide pre-computed hotword models to a mobile computing device, such that the mobile computing device can detect a candidate hotword spoken by a user associated with the mobile computing device through an analysis of the acoustic features of a portion of an utterance, without requiring the portion to be transcribed or semantically interpreted.", "The hotword models can be generated based on audio data obtained from multiple users speaking multiple words or sub-words, including words or sub-words that make up the candidate hotword.", "In some examples, a user desires to make the words “start computer” a hotword to initiate a “wake up” process on a mobile computing device, such as a smartphone.", "The user speaks the words “start computer” and, in response, the system can identify pre-computed hotword models associated with the term “start computer,” or of the constituent words “start” and “computer.” The system can provide the pre-computed hotword models to the mobile computing device such that the mobile computing device can detect whether a further utterance corresponds to the hotword “start computer,” and correspondingly wake up the mobile computing device.", "Innovative aspects of the subject matter described in this specification may be embodied in methods that include the actions of obtaining, for each of multiple words or sub-words, audio data corresponding to multiple users speaking the word or sub-word; training, for each of the multiple words or sub-words, a pre-computed hotword model for the word or sub-word based on the audio data for the word or sub-word; receiving a candidate hotword from a computing device; identifying one or more pre-computed hotword models that correspond to the candidate hotword; and providing the identified, pre-computed hotword models to the computing device.", "Other embodiments of these aspects include corresponding systems, apparatus, and computer programs, configured to perform the actions of the methods, encoded on computer storage devices.", "These and other embodiments may each optionally include one or more of the following features.", "For instance, identifying the one or more pre-computed hotword models includes obtaining two or more sub-words that correspond to the candidate hotword; and obtaining, for each of the two or more sub-words that correspond to the candidate hotword, a pre-computed hotword model that corresponds to the sub-word.", "Receiving the candidate hotword from the computing device after training, for each of the multiple words or sub-words, the pre-computed hotword model for the word or sub-word.", "Receiving the candidate hotword from the mobile computing includes receiving audio data corresponding to the candidate hotword.", "Receiving the candidate hotword from the computing device includes receiving the candidate hotword including two or more words from the computing device.", "Identifying one or more pre-computed hotword models that correspond to each word of the two or more words of the candidate hotword; and providing the identified, pre-computed hotword models that correspond to each word of the two or more words of the candidate hotword to the computing device.", "Providing, to the computing device, instructions defining a processing routine of the identified, pre-computed hotword models that correspond to each word of the two or more words of the candidate hotword.", "The instructions include instructions to sequentially process the identified, pre-computed hotword models that correspond to each word of the two or more words of the candidate hotword.", "The instructions include a processing order to sequentially process the identified, pre-computed hotword models that correspond to each word of the two or more words of the candidate hotword.", "The features further include, for instance, dynamically creating one or more hotword models that correspond to one or more words of the two or more words of the candidate hotword; and providing the dynamically created one or more hotword models that correspond to one or more words of the two or more words of the candidate hotword to the computing device.", "Dynamically creating the one or more hotword models that correspond to the one or more words of the two or more words of the candidate hotword after receiving the candidate hotword from the computing device.", "Training, for each of the multiple words or sub-words, the pre-computed hotword model for the word or sub-word, further includes for each word or sub-word of the multiple words or sub-words, obtaining, for each user of the multiple users, a transcription of the audio data of the user speaking the word or sub-word; associating, for each user of the multiple users, the audio data of the user speaking the word or sub-word with the transcription of the audio data of the user speaking the word or sub-word; and generating a particular pre-computed hotword model corresponding to the word or sub-word based on i) the audio data corresponding to each of the multiple users speaking the word or sub-word and ii) the transcription associated with the audio data corresponding to each of the multiple users speaking the word or sub-word.", "The details of one or more embodiments of the subject matter described in this specification are set forth in the accompanying drawings and the description below.", "Other potential features, aspects, and advantages of the subject matter will become apparent from the description, the drawings, and the claims." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. application Ser.", "No.", "15/463,786, filed on Mar.", "20, 2017, which is a continuation of U.S. application Ser.", "No.", "15/288,241, filed on Oct. 7, 2016 (now U.S. Pat.", "No.", "9,646,612), which is a continuation of U.S. application Ser.", "No.", "15/001,894, filed on Jan. 20, 2016 (now U.S. Pat.", "No.", "9,520,130), which is a continuation of U.S. application Ser.", "No.", "14/340,833, filed on Jul.", "25, 2014 (now U.S. Pat.", "No.", "9,263,042).", "The disclosures of the prior applications are considered part of and are incorporated by reference in the disclosure of this application.", "FIELD The present disclosure generally relates to speech recognition.", "BACKGROUND The reality of a speech-enabled home or other environment—that is, one in which a user need only speak a query or command out loud and a computer-based system will field and answer the query and/or cause the command to be performed—is upon us.", "A speech-enabled environment (e.g., home, workplace, school, etc.)", "can be implemented using a network of connected microphone devices distributed throughout the various rooms or areas of the environment.", "Through such a network of microphones, a user has the power to orally query the system from essentially anywhere in the environment without the need to have a computer or other device in front of him/her or even nearby.", "For example, while cooking in the kitchen, a user might ask the system “how many milliliters in three cups?” and, in response, receive an answer from the system, e.g., in the form of synthesized voice output.", "Alternatively, a user might ask the system questions such as “when does my nearest gas station close,” or, upon preparing to leave the house, “should I wear a coat today?” Further, a user may ask a query of the system, and/or issue a command, that relates to the user's personal information.", "For example, a user might ask the system “when is my meeting with John?” or command the system “remind me to call John when I get back home.” In a speech-enabled environment, a user's manner of interacting with the system is designed to be primarily, if not exclusively, by means of voice input.", "Consequently, a system which potentially picks up all utterances made in the environment, including those not directed to the system, must have some way of discerning when any given utterance is directed at the system as opposed, e.g., to being directed an individual present in the environment.", "One way to accomplish this is to use a “hotword” (also referred to as an “attention word” or “voice action initiation command”), which by agreement is reserved as a predetermined term that is spoken to invoke the attention of the system.", "In one example environment, the hotword used to invoke the system's attention is the word “Google.” Consequently, each time the word “Google” is spoken, it is picked up by one of the microphones, and is conveyed to the system, which performs speech recognition techniques to determine whether the hotword was spoken and, if so, awaits an ensuing command or query.", "Accordingly, utterances directed at the system take the general form [HOTWORD] [QUERY], where “HOTWORD” in this example is “Google” and “QUERY” can be any question, command, declaration, or other request that can be speech recognized, parsed and acted on by the system, either alone or in conjunction with a server over network.", "SUMMARY According to some innovative aspects of the subject matter described in this specification, a system can provide pre-computed hotword models to a mobile computing device, such that the mobile computing device can detect a candidate hotword spoken by a user associated with the mobile computing device through an analysis of the acoustic features of a portion of an utterance, without requiring the portion to be transcribed or semantically interpreted.", "The hotword models can be generated based on audio data obtained from multiple users speaking multiple words or sub-words, including words or sub-words that make up the candidate hotword.", "In some examples, a user desires to make the words “start computer” a hotword to initiate a “wake up” process on a mobile computing device, such as a smartphone.", "The user speaks the words “start computer” and, in response, the system can identify pre-computed hotword models associated with the term “start computer,” or of the constituent words “start” and “computer.” The system can provide the pre-computed hotword models to the mobile computing device such that the mobile computing device can detect whether a further utterance corresponds to the hotword “start computer,” and correspondingly wake up the mobile computing device.", "Innovative aspects of the subject matter described in this specification may be embodied in methods that include the actions of obtaining, for each of multiple words or sub-words, audio data corresponding to multiple users speaking the word or sub-word; training, for each of the multiple words or sub-words, a pre-computed hotword model for the word or sub-word based on the audio data for the word or sub-word; receiving a candidate hotword from a computing device; identifying one or more pre-computed hotword models that correspond to the candidate hotword; and providing the identified, pre-computed hotword models to the computing device.", "Other embodiments of these aspects include corresponding systems, apparatus, and computer programs, configured to perform the actions of the methods, encoded on computer storage devices.", "These and other embodiments may each optionally include one or more of the following features.", "For instance, identifying the one or more pre-computed hotword models includes obtaining two or more sub-words that correspond to the candidate hotword; and obtaining, for each of the two or more sub-words that correspond to the candidate hotword, a pre-computed hotword model that corresponds to the sub-word.", "Receiving the candidate hotword from the computing device after training, for each of the multiple words or sub-words, the pre-computed hotword model for the word or sub-word.", "Receiving the candidate hotword from the mobile computing includes receiving audio data corresponding to the candidate hotword.", "Receiving the candidate hotword from the computing device includes receiving the candidate hotword including two or more words from the computing device.", "Identifying one or more pre-computed hotword models that correspond to each word of the two or more words of the candidate hotword; and providing the identified, pre-computed hotword models that correspond to each word of the two or more words of the candidate hotword to the computing device.", "Providing, to the computing device, instructions defining a processing routine of the identified, pre-computed hotword models that correspond to each word of the two or more words of the candidate hotword.", "The instructions include instructions to sequentially process the identified, pre-computed hotword models that correspond to each word of the two or more words of the candidate hotword.", "The instructions include a processing order to sequentially process the identified, pre-computed hotword models that correspond to each word of the two or more words of the candidate hotword.", "The features further include, for instance, dynamically creating one or more hotword models that correspond to one or more words of the two or more words of the candidate hotword; and providing the dynamically created one or more hotword models that correspond to one or more words of the two or more words of the candidate hotword to the computing device.", "Dynamically creating the one or more hotword models that correspond to the one or more words of the two or more words of the candidate hotword after receiving the candidate hotword from the computing device.", "Training, for each of the multiple words or sub-words, the pre-computed hotword model for the word or sub-word, further includes for each word or sub-word of the multiple words or sub-words, obtaining, for each user of the multiple users, a transcription of the audio data of the user speaking the word or sub-word; associating, for each user of the multiple users, the audio data of the user speaking the word or sub-word with the transcription of the audio data of the user speaking the word or sub-word; and generating a particular pre-computed hotword model corresponding to the word or sub-word based on i) the audio data corresponding to each of the multiple users speaking the word or sub-word and ii) the transcription associated with the audio data corresponding to each of the multiple users speaking the word or sub-word.", "The details of one or more embodiments of the subject matter described in this specification are set forth in the accompanying drawings and the description below.", "Other potential features, aspects, and advantages of the subject matter will become apparent from the description, the drawings, and the claims.", "DESCRIPTION OF DRAWINGS FIG.", "1 depicts an example system for providing hotword models.", "FIG.", "2 depicts an example graphical user interface for identifying a user provided hotword.", "FIG.", "3 depicts an example flowchart for providing hotword models.", "FIG.", "4 depicts a computer device and a mobile computer device that may be used to implement the techniques described here.", "In the drawings, like reference symbols indicate like elements throughout.", "DETAILED DESCRIPTION FIG.", "1 depicts a system 100 for providing pre-computed hotword models.", "In some examples, the system 100 includes mobile computing devices 102, 104, 106, a speech recognition engine 108, a vocabulary database 110, and a hotword configuration engine 112.In some examples, any of the mobile computing devices 102, 104, 106 may be a portable computer, a smartphone, a tablet-computing device, or a wearable computing device.", "Each of the mobile computing devices 102, 104, 106 are associated with a respective user 114, 116, 118.The mobile computing devices 102, 104, 106 can include any audio detection means, e.g., a microphone, for detecting utterances from the respective associated user 114, 116, 118.The mobile computing devices 102 and 104 are in communication with the speech recognition engine 108, e.g., over one or more networks, and the mobile computing device 106 is in communication with the hotword configuration engine 112, e.g., over one or more networks.", "In some implementations, the speech recognition engine 108 obtains, for each of multiple words or sub-words, audio data that corresponds to multiple users speaking the word or sub-words, during operation (A).", "Specifically, the speech recognition engine 108 obtains audio data from the mobile computing devices 102 and 104 that correspond, respectively, to the users 114 and 116 speaking words or sub-words, e.g., over one or more networks.", "In some examples, the user 114 and the user 116 each say one or more words that the mobile computing device 102 and mobile computing device 104, respectively detect.", "In some examples, the users 114 and 116 speak the words or sub-words during any interaction with the mobile computing devices 102 and 104, respectively, e.g., submitting voice queries for voice commands.", "In some examples, in addition to obtain the audio data associated with the users 114 and 116 speaking the words or sub-words, the speech recognition engine 108 obtains a locale of the users 114 and 116 from the mobile computing device 102 and 104.The locale can include the approximate current location of the user when speaking the words or sub-words, or a location associated with a profile of the user.", "For example, the user 114 says the utterance 150 of “start my car” and the user 116 says the utterance 152 of “where do I buy a computer?” The mobile computing device 102 detects the utterance 150 of “start my car” to generate waveform data 120 that represents the detected utterance 150; and the mobile computing device 104 detects the utterance 152 of “where do I buy a computer?” to generate waveform data 122 that represents the detected utterance 152.The mobile computing devices 102 and 104 transmit the waveforms 120 and 122, respectively, to the speech recognition engine 108, e.g., over one or more networks.", "In some examples, the speech recognition engine 108, for each word or sub-word of the multiple words or sub-words, obtains, for each user of the multiple users, a transcription of the audio data of the user speaking the word or the sub-word, during operation (B).", "Specifically, the speech recognition engine 108 processes the received audio data, including generating a transcription of an utterance of words or sub-words associated with the audio data.", "Generating the transcription of the audio data of the user speaking the word or the sub-word can include transcribing the utterance into text or text-related data.", "In other words, the speech recognition engine 108 can provide a representation of natural language in written form of the utterance associated with the audio data.", "For example, the speech recognition engine 108 transcribes the waveforms 120 and 122, as received from the mobile computing devices 102 and 104, respectively.", "That is, the speech recognition engine 108 transcribes the waveform 120 to generate the transcription 124 of “start my car” and transcribes the waveform 122 to generate the transcription 126 of “where do I buy a computer?” In some examples, the speech recognition engine 108, for each word or sub-word of the multiple words or sub-words, associates, for each user of the multiple users, the audio data of the user speaking the word or sub-word with the transcription of the audio data of the user speaking the word or sub-word, during operation (C).", "For example, the speech recognition engine 108 associates the waveform 160 with the transcription 124 and associates the waveform 162 with the transcription 126.In some examples, the waveform 160 is substantially the same as the waveform 120, and the waveform 162 is substantially the same as the waveform 122.In some examples, the waveform 160 is a processed version (e.g., by the speech recognition engine 108) of the waveform 120, and the waveform 162 is a processed version (e.g., by the speech recognition engine 108) of the waveform 122.In some examples, the speech recognition engine 108 associates a portion of the waveform 160 with a corresponding portion of the transcription 124.That is, for each word, or sub-word, of the waveform 160, the speech recognition engine 108 associates the corresponding portion of the transcription 124 with the word, or sub-word.", "For example, the speech recognition engine 108 associates a portion of the waveform 160 for each of the words “start,” “my,” “car” with the corresponding portion of the transcription 124.Similarly, the speech recognition engine 108 associates a portion of the waveform 162 for each of the words “where,” “do,” “I,” “buy,” “a,” “computer” with the corresponding portion of the transcription 126.In some examples, the speech recognition engine 108 associates a portion of the waveform 160 for each of the sub-words, e.g., phoneme or tri-phone level, of each word, e.g., “st-ah-rt” of the word “start,” with the corresponding portion of the transcription.", "Similarly, in some examples, the speech recognition engine 108 associates a portion of the waveform 162 for each of the sub-words, e.g., phoneme or tri-phone level, of each word, e.g., “kom-pyu-ter” of the word “computer,” with the corresponding portion of the transcription.” In some examples, associating the audio data of the user speaking the word or sub-word with the transcription of the audio data of the user speaking the word or sub-word includes storing the association in a database, or a table.", "Specifically, the speech recognition engine 108 provides the transcription 124 and the waveform 160 to the vocabulary database 110 such that the vocabulary database 110 stores an association between the waveform 160 and the transcription 124.Similarly, the speech recognition engine 108 provides the transcription 126 and the waveform 162 to the vocabulary database 110 such that the vocabulary database 110 stores an association between the waveform 162 and the transcription 126.In some examples, the speech recognition engine 108 provides the locale associated with the word or sub-words of the transcription 124 (e.g., the locale of the user 114) to the vocabulary database 110 such that the vocabulary database 110 additionally stores an association between the waveform 160, the transcription 124, and the respective locale.", "Similarly, the speech recognition engine 108 provides the locale associated with the word or sub-words of the transcription 126 (e.g., the locale of the user 116) to the vocabulary database 110 such that the vocabulary database 110 additionally stores an association between the waveform 162, the transcription 126, and the respective locale In some examples, the vocabulary database 110 indicates an association between a portion of the waveform 160 with a corresponding portion of the transcription 124.That is, for each word, or sub-word, of the waveform 160, the vocabulary database 110 stores an association of the portion of the waveform 160 with a corresponding portion of the transcription 124 with the word, or sub-word.", "For example, the vocabulary database 110 stores an association of a portion of the waveform 160 for each of the words “start,” “my,” “car” with the corresponding portion of the transcription 124.Similarly, the vocabulary database 110 stores an association of a portion of the waveform 162 for each of the words “where,” “do,” “I,” “buy,” “a,” “computer” with the corresponding portion of the transcription 126.In some implementations, the hotword configuration engine 112 trains, for each of the multiple words or sub-words, a pre-computed hotword model for the word or sub-word, during operation (D).", "Specifically, the hotword configuration engine 112 is in communication with the vocabulary database 110, and obtains, for each word or sub-word stored by the vocabulary database 110, the audio data of each user of the multiple users speaking the word or sub-word and the associated transcription of the audio data.", "For example, the hotword configuration engine 112 obtains, from the vocabulary database 110, the waveform 160 and the associated transcription 124, and further obtains the waveform 162 and the associated transcription 126.In some examples, for each word or sub-word stored by the vocabulary database 110, the hotword configuration engine 112 generates a pre-computed hotword model corresponding to the word or sub-word.", "Specifically, the hotword configuration engine 112 generates the pre-computed hotword model for each word or sub-word based on i) the audio data corresponding to each of the multiple users speaking the word or sub-word and ii) the transcription associated with the audio data corresponding to each of the multiple users speaking the word or sub-word.", "In some examples, the pre-computed hotword model can be a classifier such as a neural network, or a support vector machine (SVM).", "For example, the hotword configuration engine 112 generates a pre-computed hotword model corresponding to each word or sub-word of the waveforms 160 and 162.In some examples, for the word “start” of the waveform 160, the hotword configuration engine 112 generates a pre-computed hotword model for the word based on i) the audio data corresponding to the user 114 speaking the word “start” (e.g., the portion of the waveform 160 corresponding to the user 114 speaking the word “start”) and ii) the transcription associated with the audio data corresponding to the user 114 speaking the word “start.” Additionally, the hotword configuration engine 112 can generate a pre-computed hotword model for the remaining words “my” and “car” of the waveform 160, as well as each sub-word (of each word) of the waveform 160, e.g., “st-ah-rt” of the word “start.” Additionally, in some examples, for the word “computer” of the waveform 162, the hotword configuration engine 112 generates a pre-computed hotword model for the word based on i) the audio data corresponding to the user 116 speaking the word “computer” (e.g., the portion of the waveform 162 corresponding to the user 116 speaking the word “computer”) and ii) the transcription associated with the audio data corresponding to the user 116 speaking the word “computer.” Additionally, the hotword configuration engine 112 can generate a pre-computed hotword model for the remaining words “where,” “do,” “I,” “buy” and “a” of the waveform 162, as well as each sub-word of the waveform 160, e.g., “kom-pyu-ter” of the word “computer.” The hotword configuration engine 112, after pre-computing the hotword models for one or more words stored by the vocabulary database 110, provides the pre-computed hotword models 128 to the vocabulary database 110 such that the vocabulary database 110 stores or otherwise indicates an association between the words or sub-words and the corresponding pre-computed hotword models 128.That is, for each word or sub-word of the waveforms 160 and 162, the vocabulary database 110 stores an association between each of the words or sub-words (e.g., of the waveforms 160 and 162) and the corresponding pre-computed hotword models 128.In some examples, the vocabulary database 110 stores, for each word or sub-word of the waveforms 160 and 162, an association between i) the portion of the waveform corresponding to the word or sub-word, ii) the corresponding transcription of the portion of the waveform, and iii) the corresponding pre-computed hotword model.", "For example, for the word “start” of the waveform 160, the vocabulary database 110 stores i) an association of a portion of the waveform 160 corresponding to the word “start,” ii) a portion of the transcription 124 corresponding to the word “start,” and iii) a pre-computed hotword model 128 for the word “start.” In some implementations, the hotword configuration engine 112 receives a candidate hotword 129 from the mobile computing device 106, during operation (E).", "Specifically, the hotword configuration engine 112 receives, e.g., over one or more networks, data from the mobile computing device 106 that corresponds to the user 118 providing the candidate hotword 129.In some examples, the mobile computing device 106 provides a graphical user interface 180 to the user 118 that provides for display of text 182 to prompt the user 118 to provide a hotword.", "For example, the text 182 includes “Please say your desired Hotword.” In response, the user 118 says the candidate hotword 129 that the mobile computing device 106 detects, and transmits to the hotword configuration engine 112.For example, the user 118 says the utterance 170 of “start computer” that corresponds to the candidate hotword 129.The mobile computing device 106 detects the utterance 170 of “start computer” and generates a waveform 130 that represents the detected utterance 170.The mobile computing device 106 transmits the waveform 130 to the hotword configuration engine 112, e.g., over one or more networks.", "In some examples, the user 118 provides text-based input to the mobile computing device 106, e.g., via a graphical user interface of the mobile computing device 106, that corresponds to the candidate hotword 129.For example, the user 118 inputs via a keyboard, virtual or tactile, the text of “start computer.” The mobile computing device 106 transmits the text-based candidate hotword 129 of “start computer” to the hotword configuration engine 112, e.g., over one or more networks.", "In some examples, the hotword configuration engine 112 receives the candidate hotword from the mobile computing device 106 after training, for each of the multiple words or sub-words, the pre-computed hotword model for the word or sub-word.", "Specifically, the hotword configuration engine 112 receives the candidate hotword 129 from the mobile computing device 106 after the hotword configuration engine 112 generates the pre-computed hotword models 128 corresponding to each of the words or sub-words stored by the vocabulary database 110.For example, the hotword configuration engine 112 receives the candidate hotword 129 of “start computer” from the mobile computing device 106 after training, for each of the multiple words or sub-words of the waveforms 160 and 162, the pre-computed hotword models 128 for the word or sub-word.", "In some examples, the hotword configuration engine 112 receives the candidate hotword 129 that includes two or more words from the mobile computing device 106.For example, the hotword configuration engine 112 receives the candidate hotword 129 of “start computer” that includes two words (e.g., “start” and “computer”).", "In some examples, the hotword configuration engine 112 receives the candidate hotword 129 that includes a single word from the mobile computing device 106.In some examples, the hotword configuration engine 112 obtains two or more sub-words that correspond to the candidate hotword 129.That is, the hotword configuration engine 112 processes the candidate hotword 129 to identify sub-words of the candidate hotword 129.For example, for the candidate hotword 129 of “start computer,” the hotword configuration engine 112 can obtain the sub-words of “st-ah-rt” for the word “start” of the candidate hotword 129 and further obtain the sub-words of “kom-pyu-ter” for the word “computer” of the candidate hotword 129.In some implementations, the hotword configuration engine 112 identifies one or more pre-computed hotword models that correspond to the candidate hotword 129, at operation (F).", "Specifically, the hotword configuration engine 112 accesses the vocabulary database 110 to identify one or more of the pre-computed hotword models 128 that are stored by the vocabulary database 110 and that correspond to the candidate hotword 129.The hotword configuration engine 112 retrieves the pre-computed hotword models 128 from the vocabulary database 110, e.g., over one or more networks.", "In some examples, the hotword configuration engine 112 identifies the pre-computed hotword models 128 that are associated with the words, or sub-words, of the candidate hotword 129.The hotword configuration engine 112 can identify the pre-computed hotword models 128 by matching the words, or sub-words, of the candidate hotword 129 with the words, or sub-words, that are stored by the vocabulary database 110.In some examples, the hotword configuration engine 112 identifies the pre-computed hotword models 128 that correspond to the utterance 170 of the candidate hotword 129 provided by the user 118.That is, the hotword configuration engine 112 identifies the one or more pre-computed hotword models 128 based on the waveform 130 that represents the detected utterance 170 of the candidate hotword 129.In the illustrated example, the hotword configuration engine 112 identifies one or more pre-computed hotword models 128 stored by the vocabulary database 110 that correspond to the utterance 170 of “start computer.” In some examples, when the candidate hotword includes two or more words, the hotword configuration engine 112 identifies the pre-computed hotword models that correspond to each word of the two or more words.", "That is, each word of the two or more words of the candidate hotword 129 corresponds to a pre-computed hotword model 128 stored by the vocabulary database 110.For example, the candidate hotword 129 includes two words, e.g., “start” and “computer.” To that end, the hotword configuration engine 112 identifies a first pre-computed hotword model 128 stored by the vocabulary database 110 corresponding to the word “start” and a second pre-computed hotword model 128 stored by the vocabulary database 110 corresponding to the word “computer.” In some examples, the hotword configuration engine 112 identifies a pre-computed hotword model 128 stored by the vocabulary database 110 corresponding to the both words “start computer.” In some examples, the hotword configuration engine 112 identifies the one or more pre-computed hotword models 128 that correspond to the utterance 170 of the candidate hotword 129 by matching at least a portion of the waveform 130 to at least a portion of waveforms stored by the vocabulary database 110.Matching the waveform 130 to waveforms stored by the vocabulary database 110 can include performing an audio-based comparison between the waveform 130 and the waveforms stored by the vocabulary database 110 to identify a matching waveform stored by the vocabulary database 110 to the waveform 130.In some examples, the audio-based comparison between the waveform 130 and the waveforms stored by the vocabulary database 110 can be performed by an audio processing engine that is in communication with the hotword configuration engine 112, e.g., over one or more networks.", "To that end, upon the hotword configuration engine 112 identifying a matching waveform stored by the vocabulary database 110 to the waveform 130, the hotword configuration engine 112 identifies the pre-computed hotword models 128 associated with the matching waveform.", "In some examples, the hotword configuration engine 112 identifies the one or more pre-computed hotword models 128 that correspond to the utterance 170 of the candidate hotword 129 by applying one or more of the pre-computed hotword models 128 stored by the vocabulary database 110 to the utterance 170 to identify the pre-computed hotword models 128 corresponding with a highest confidence score relative to the remaining pre-computed hotword models 128.The confidence score indicates the likelihood that the identified pre-computed hotword model 128 corresponds to the utterance 170.For example, the hotword configuration engine 112 can match the waveform 130 to a portion of one or more of the waveforms 160 and 162 that are stored by the vocabulary database 110.Specifically, the hotword configuration engine 112 can match a portion of the waveform 130 that corresponds to the word “start” with a portion of the waveform 160 stored by the vocabulary database 110 that corresponds to the word “start.” Based on this matching, the hotword configuration engine 112 can identify the corresponding pre-computed hotword model 128 that is associated with the portion of the waveform 160 for the word “start.” Similarly, the hotword configuration engine 112 can match a portion of the waveform 130 that corresponds to the word “computer” with a portion of the waveform 162 stored by the vocabulary database 110 that corresponds to the word “computer.” Based on this matching, the hotword configuration engine 112 can identify the corresponding pre-computed hotword model 128 that is associated with the portion of the waveform 162 for the word “computer.” In some examples, the hotword configuration engine 112 identifies the one or more pre-computed hotword models 128 that correspond to the utterance of the candidate hotword 129 by matching at least a portion of a transcription of the waveform 130 to at least a portion of transcriptions stored by the vocabulary database 110.Specifically, the hotword configuration engine 112 can provide the waveform 130 to a speech recognition engine, e.g., the speech recognition engine 108, such that speech recognition engine 108 transcribes the waveform 130.To that end, matching the transcription of the waveform 130 to transcriptions stored by the vocabulary database 110 can include comparing the transcription of the waveform 130 to the transcriptions stored by the vocabulary database 110 to identify a matching transcription stored by the vocabulary database 110 to the waveform 130.To that end, upon the hotword configuration engine 112 identifying a matching transcription stored by the vocabulary database 110 to the transcription of the waveform 130, the hotword configuration engine 112 identifies the pre-computed hotword models 128 associated with the matching transcription.", "For example, the hotword configuration engine 112 can match the transcription of the waveform 130 to a portion of one or more of the transcriptions 124 and 126 that are stored by the vocabulary database 110.Specifically, the hotword configuration engine 112 can match a portion of the transcription of the waveform 130 that corresponds to the word “start” with a portion of the transcription 124 stored by the vocabulary database 110 that corresponds to the word “start.” Based on this matching, the hotword configuration engine 112 can identify the corresponding pre-computed hotword model 128 that is associated with the portion of the transcription 124 for the word “start.” Similarly, the hotword configuration engine 112 can match a portion of the transcription of the waveform 130 that corresponds to the word “computer” with a portion of the transcription 126 stored by the vocabulary database 110 that corresponds to the word “computer.” Based on this matching, the hotword configuration engine 112 can identify the corresponding pre-computed hotword model 128 that is associated with the portion of the transcription 126 for the word “computer.” In some examples, matching the words, or sub-words, of the candidate hotword 129 with words, or sub-words, that are stored by the vocabulary database 110 can include determining a full match between the words, or sub-words, of the candidate hotword 129 with words, or sub-words that are stored by the vocabulary database 110.In some examples, matching the words, or sub-words, of the candidate hotword 129 with words, or sub-words, that are stored by the vocabulary database 110 can include determining a partial match between the words, or sub-words, of the candidate hotword 129 with words, or sub-words that are stored by the vocabulary database 110.In some examples, the hotword configuration engine 112 obtains the pre-computed hotword models 128 for the sub-words that correspond to the candidate hotword 129.As mentioned above, for the candidate hotword 129 of “start computer,” the hotword configuration engine 112 identifies the sub-words of “st-ah-rt” for the word “start” of the candidate hotword 129 and further identifies the sub-words of “kom-pyu-ter” for the word “computer” of the candidate hotword 129.To that end, the hotword configuration engine 112 accesses the vocabulary database 110 to identify the pre-computed hotword models 128 that are stored by the vocabulary database 110 and that correspond to the sub-words of the candidate hotword 129.The hotword configuration engine 112 can identify the pre-computed hotword models 128 by matching the sub-words of the candidate hotword 129 with the sub-words that are stored by the vocabulary database 110 and are associated with the pre-computed hotword models 128.For example, the hotword configuration engine 112 identifies the one or more pre-computed hotword models 128 stored by the vocabulary database 110 that correspond to the each of the sub-words of “st-ah-rt” for the word “start” of the candidate hotword 129 and each of the sub-words of “kom-pyu-ter” for the word “computer” of the candidate hotword 129.In some implementations, the hotword configuration engine 112 provides the identified, pre-computed hotword models to the mobile computing device 106, at operation (G).", "Specifically, the hotword configuration engine 112 provides the pre-computed hotword models 134, e.g., a subset of the pre-computed hotword models 128, corresponding to the candidate hotword 129 to the mobile computing device 106, e.g., over one or more networks.", "For example, the hotword configuration engine 112 can provide the pre-computed hotword models 134 that correspond to the candidate hotword 129 of “start computer” to the mobile computing device 106.In some examples, the hotword configuration engine 112 provides the identified, pre-computed hotword models 134 that correspond to each word of the two or more words of the candidate hotword 129 to the mobile computing device 106.For example, the candidate hotword 129 includes two words, e.g., “start” and “computer,” and the hotword configuration engine 112 provides the pre-computed hotword models 134 that correspond to each word.", "That is, the hotword configuration engine 112 provides a first pre-computed hotword model 134 corresponding to the word “start” and a second pre-computed hotword model 134 corresponding to the word “computer” to the mobile computing device 106.In some examples, the identified, pre-computed hotword models 134 are provided to the mobile computing device 106 based on a type of the mobile computing device 106.For example, a lower-end, or lower processing power, mobile computing device is more suitable to receive an appropriate version (e.g., smaller neural network) of the pre-computed hotword models 134 such that the mobile computing device is able to appropriately process the pre-computed hotword models 134.In some examples, the mobile computing device 106 can receive two or more pre-computed hotword models 134 in response to a command (or query) from the user 118.That is, the user 118 can provide a command such as “navigate to coffee house” to the mobile computing device 106.In response, the mobile computing device 106 can receive pre-computed hotword models 134 that correspond to two differing locations of coffee houses that are proximate to the user's 118 current location.", "For example, the mobile computing device 106 can receive a pre-computed hotword model 135 for “Palo Alto” and a pre-computed hotword model 134 for “Mountain View.” The mobile computing device 106 can provide both location options to the user 118 (e.g., via sound or the graphical user interface of the mobile computing device 106).", "The user 118 can provide an utterance of one of the locations that the mobile computing device 106 can detect via the received pre-computed hotword models 134, as described above.", "In some examples, by generating the pre-computed hotword models 128 and providing the same to the vocabulary database 110, the pre-computed hotword models are instantaneously available (or nearly instantaneously available) for identifying hotwords from utterances, e.g., by the mobile computing device 106.For example, the mobile computing device 106 is able to instantaneously obtain the hotword models that correspond to the words “start” and “computer” such that the mobile computing device 106 is able to appropriately process the utterance 170 close to detection of utterance 170.In some examples, by generating the pre-computed hotword models 128 trained on utterances of other users (e.g., users 114 and 116) that are not available to the mobile computing device 106, the pre-computed hotword models 128 employed by the mobile computing device 106 to process the utterance 170 can be more robust as compared to hotword models 128 trained on utterances only provided by the user 118.In some examples, the hotword configuration engine 112 provides, to the mobile computing device 106, instructions 136 that define a processing routine of the pre-computed hotword models 134.That is, the instructions 136 define how the mobile computing device 106 is to appropriately process the pre-computed hotword models 134.In some examples, the pre-computed hotword models 134 detect hotwords (e.g., of utterances) based on an analysis of underlying acoustic features (e.g., mel-frequency cepstrum coefficients) of an input utterance (e.g., utterance 170).", "In some examples, the instructions 136 include instructions to sequentially process the hotword models 134, and further include a processing order of the hotword models 134.For example, the instructions 136 can include instructions to initially process the pre-computed hotword model 134 corresponding to the word “start” and subsequently process the pre-computed hotword model 134 corresponding to the word “computer.” In some examples, the instructions 136 include instructions to parallel process the hotword models 134.For example, the instructions 136 can include instructions to process the pre-computed hotword model 134 corresponding to the word “start” and process the pre-computed hotword model 134 corresponding to the word “computer” in parallel, e.g., at substantially the same time.", "In some examples, the instructions 136 include instructions to process the hotword models 134 such that a second hotword model 134 corresponding to the word “computer” is processed only when a first hotword model 134 detects the hotword “start.” In other words, upon detection of the word “computer” by the first hotword model 134, the mobile computing device 106 triggers processing of the second hotword model 134 corresponding to the word “computer.” The mobile computing device 106 receives the pre-computed hotword models 134, and in some examples, the instructions 136, from the hotword configuration engine 112, e.g., over one or more networks.", "The mobile computing device 106 stores the pre-computed models 134 in memory of the mobile computing device 106.Thus, upon detection of an utterance by the user 118 at a later time (e.g., after receiving the pre-computed hotword models 134), the mobile computing device 106 can appropriately process the utterance in view of the pre-computed hotword models 134 to determine whether the utterance corresponds to the candidate hotword 129.In some further implementations, the hotword configuration engine 112 dynamically creates one or more of the hotword models that correspond to candidate hotword 129.That is, in response to receiving the candidate hotword 129 from the mobile computing device 106, the hotword configuration engine 112 dynamically creates a hotword model that corresponds to one or more words of the candidate hotword 129.In some examples, the hotword configuration engine 112 dynamically creates the hotword models for the candidate hotword 129 based on i) the waveform 130 and ii) an obtained transcription of the waveform 130, e.g., from the speech recognition engine 108.For example, for the word “start” of the waveform 130, the hotword configuration engine 112 dynamically creates a hotword model for the word based on i) a portion of the waveform 130 corresponding to the user 118 speaking the word “start” and ii) a transcription associated with the waveform 130 corresponding to the user 118 speaking the word “start.” In some examples, as mentioned above, the hotword configuration engine 112 matches at least a portion of the waveform 130 to at least a portion of the waveforms stored by the vocabulary database 110.Upon the matching, the hotword configuration engine 112 can further identify a portion of the corresponding transcription associated with the matched waveform that is stored by the vocabulary database 110.To that end, the hotword configuration engine 112 dynamically creates the hotword model corresponding to the candidate hotword 129 based on i) the matched waveform and ii) the corresponding transcription associated with the matched waveform.", "For example, the hotword configuration engine 112 can identify a portion of the waveform 160 stored by the vocabulary database 110 corresponding to the word “start” and further identify the corresponding transcription 124 of the portion of the waveform 160 that includes the word “start.” The hotword configuration engine 112 can dynamically create the hotword model for the word “start” of the candidate hotword 129 based on i) the portion of the waveform 160 stored by the vocabulary database 110 corresponding to the word “start” and ii) the corresponding transcription 124 that includes the word “start.” In some examples, as mentioned above, the hotword configuration engine 112 matches at least a portion of a transcription of the waveform 130 to at least a portion of transcriptions stored by the vocabulary database 110.Upon the matching, the hotword configuration engine 112 can further identify the corresponding waveform associated with the matched transcription that is stored by the vocabulary database 110.To that end, the hotword configuration engine 112 dynamically creates the hotword model corresponding to the candidate hotword 129 based on i) the matched transcription and ii) the corresponding waveform associated with the matched transcription.", "For example, the hotword configuration engine 112 can identify a portion of the transcription 124 stored by the vocabulary database 110 corresponding to the word “start” and further identify the corresponding portion of the waveform 160 that includes the word “start.” The hotword configuration engine 112 can dynamically create the hotword model for the word “start” of the candidate hotword 129 based on i) the portion of the transcription 124 stored by the vocabulary database 110 corresponding to the word “start” and ii) the corresponding portion of the waveform 160 that includes the word “start.” In some examples, the hotword configuration engine 112 provides the dynamically created hotword models to the mobile computing device 106, e.g., over one or more networks.", "For example, the hotword configuration engine 112 can provide dynamically created hotword models 134 that correspond to the word “start” of the candidate hotword “start computer” to the mobile computing device 106.In some examples, the hotword configuration engine 112 can provide i) the dynamically created hotword model that corresponds to the word “start” of the candidate hotword 129 “start computer” and provide ii) the pre-computed hotword model 134 that corresponds to the word “computer” of the candidate hotword 129 “start computer” to the mobile computing device 106.In some examples, the hotword configuration engine 112 dynamically creates the hotword models that correspond to the candidate hotword 129 after receiving the candidate hotword 129 from the mobile computing device 106.For example, the hotword configuration engine 112 dynamically creates the hotword models that correspond to the candidate hotword 129 of “start computer” after receiving the candidate hotword 129 from the mobile computing device 106.FIG.", "2 illustrates example graphical user interface (GUI) 202 of a mobile computing device 204 for identifying a user provided hotword.", "The mobile computing device 204 can be similar to the mobile computing device 106 of FIG.", "1.To that end, the mobile computing device 204 provides a first GUI 202a to a user 206 associated with the mobile computing device 204 that provides for display initiation of the process to identify the user provided hotword to be associated with an action (e.g., a process performed at least partially by the mobile computing device 204).", "In some examples, the first GUI 202a includes text 208 indicating to the user 206 to provide a hotword.", "For example, the text 208 includes “What would you like your Hotword to be to initiate a web search?” The user 206 provides an utterance 210 that the mobile computing device 204 detects.", "For example, the user 206 says the utterance 210 of “go gadget go” that the user 206 desires to be a hotword to initiate a web search.", "In response to detecting the utterance 210, the mobile computing device 204 provides a second GUI 202b to the user 206 that provides for display a proposed transcription of the detected utterance 210.In some examples, the second GUI 202b includes text 212 indicating to the user 206 to confirm, or reject, a transcription of the utterance 210.For example, the text 212 includes “We think you said ‘Go gadget go.’ If yes, please hit confirm button.", "If no, please hit reject button, and speak Hotword again.” To that end, the second GUI 202b further includes selectable buttons 214 and 216 that the user 206 is able to select to indicate whether to confirm that the transcription is correct, or reject the transcription.", "For example, upon selection of the selectable button 214 by the user 206, the mobile computing device 204 receives a confirmation that the transcription of “Go gadget go” corresponds to the utterance 210.Further, for example, upon selection of the selectable button 216 by the user 206, the mobile computing device 204 receives a rejection of the transcription corresponding to the utterance 210, e.g., an incorrect or inaccurate transcription.", "In some examples, the proposed transcription of the detected utterance 210 is not provided to the user 206 via the second GUI 202b.", "In response to receiving a confirmation that the transcription is correct, the mobile computing device 204 provides a third GUI 202c to the user 206 that provides for display a confirmation of the transcription of the detected utterance 210.In some examples, the third GUI 202c includes text 218 indicating to the user 206 that the user 206 has confirmed that the transcription of the utterance 210 is correct.", "For example, the text 218 includes “We have confirmed that your Hotword is ‘Go gadget go.’” Thus, the words “Go gadget go” have been established as associated with a hotword, and further associated with an action of initiating a web search.", "After establishing the hotword by the user 206, the user 206 can provide a hotword 220, e.g., via an utterance or text-input, to the mobile computing device 206, e.g., after identifying the user provided hotword.", "For example, the hotword 220 can include the words “go gadget go.” Thus, in response to receiving the hotword 220 of “go gadget go,” the mobile computing device 206 causes one or more actions to be performed, including initiating a web search, and provides a fourth GUI 202d to the user 206 that provides for display a description of the action to be taken associated with receiving the hotword 220.In some examples, the fourth GUI 202d includes text 222 of “Starting Search .", ".", ".", ".” FIG.", "3 depicts a flowchart of an example process 300 for providing hotword models.", "The example process 300 can be executed using one or more computing devices.", "For example, the mobile computing device 102, 104, 106, the speech recognition engine 108, and the hotword configuration engine 112 can be used to execute the example process 500.For each of multiple words or sub-words, audio data corresponding to multiple users speaking the word or sub-word is obtained (302).", "For example, the speech recognition engine 208 obtains the waveforms 120 and 122 from the mobile computing devices 102 and 104, respectively, that correspond to the user 114 speaking the utterance 150 of “start my car” and the user 116 speaking the utterance 152 of “where do I buy a computer.” For each of the multiple words or sub-words, a pre-computed hotword model for the word or sub-word is trained based on the audio for the word or sub-word (304).", "For example, the hotword configuration engine 112 trains a pre-computed hotword model for each word or sub-word based on the waveforms 120 and 122.A candidate hotword is received from a mobile computing device (306).", "For example, the hotword configuration engine 112 receives the candidate hotword 129 of “start computer” from the mobile computing device 106.One or more pre-computed hotword models are identified that correspond to the candidate hotword (308).", "For example, the hotword configuration engine 112 identifies the pre-computed hotword models 128 stored by the vocabulary database 110 that correspond to the candidate hotword 129 of “start computer.” The identified, pre-computed hotword models are provided to the mobile computing device (310).", "For example, the hotword configuration engine 112 provides the pre-computed hotword models 134 to the mobile computing device 106.FIG.", "4 shows an example of a generic computer device 400 and a generic mobile computer device 450, which may be used with the techniques described here.", "Computing device 400 is intended to represent various forms of digital computers, such as laptops, desktops, workstations, personal digital assistants, servers, blade servers, mainframes, and other appropriate computers.", "Computing device 450 is intended to represent various forms of mobile devices, such as personal digital assistants, cellular telephones, smartphones, and other similar computing devices.", "The components shown here, their connections and relationships, and their functions, are meant to be exemplary only, and are not meant to limit implementations of the inventions described and/or claimed in this document.", "Computing device 400 includes a processor 402, memory 404, a storage device 406, a high-speed interface 408 connecting to memory 404 and high-speed expansion ports 410, and a low speed interface 412 connecting to low speed bus 414 and storage device 406.Each of the components 402, 404, 406, 408, 410, and 412, are interconnected using various busses, and may be mounted on a common motherboard or in other manners as appropriate.", "The processor 402 may process instructions for execution within the computing device 400, including instructions stored in the memory 404 or on the storage device 406 to display graphical information for a GUI on an external input/output device, such as display 416 coupled to high speed interface 408.In other implementations, multiple processors and/or multiple buses may be used, as appropriate, along with multiple memories and types of memory.", "Also, multiple computing devices 400 may be connected, with each device providing portions of the necessary operations (e.g., as a server bank, a group of blade servers, or a multi-processor system).", "The memory 404 stores information within the computing device 400.In one implementation, the memory 404 is a volatile memory unit or units.", "In another implementation, the memory 404 is a non-volatile memory unit or units.", "The memory 404 may also be another form of computer-readable medium, such as a magnetic or optical disk.", "The storage device 406 is capable of providing mass storage for the computing device 400.In one implementation, the storage device 406 may be or contain a computer-readable medium, such as a floppy disk device, a hard disk device, an optical disk device, or a tape device, a flash memory or other similar solid state memory device, or an array of devices, including devices in a storage area network or other configurations.", "A computer program product may be tangibly embodied in an information carrier.", "The computer program product may also contain instructions that, when executed, perform one or more methods, such as those described above.", "The information carrier is a computer- or machine-readable medium, such as the memory 404, the storage device 406, or a memory on processor 402.The high speed controller 408 manages bandwidth-intensive operations for the computing device 400, while the low speed controller 412 manages lower bandwidth-intensive operations.", "Such allocation of functions is exemplary only.", "In one implementation, the high-speed controller 408 is coupled to memory 404, display 416 (e.g., through a graphics processor or accelerator), and to high-speed expansion ports 410, which may accept various expansion cards (not shown).", "In the implementation, low-speed controller 412 is coupled to storage device 406 and low-speed expansion port 414.The low-speed expansion port, which may include various communication ports (e.g., USB, Bluetooth, Ethernet, wireless Ethernet) may be coupled to one or more input/output devices, such as a keyboard, a pointing device, a scanner, or a networking device such as a switch or router, e.g., through a network adapter.", "The computing device 400 may be implemented in a number of different forms, as shown in the figure.", "For example, it may be implemented as a standard server 420, or multiple times in a group of such servers.", "It may also be implemented as part of a rack server system 424.In addition, it may be implemented in a personal computer such as a laptop computer 422.Alternatively, components from computing device 400 may be combined with other components in a mobile device (not shown), such as device 450.Each of such devices may contain one or more of computing device 400, 450, and an entire system may be made up of multiple computing devices 400, 450 communicating with each other.", "Computing device 450 includes a processor 452, memory 464, an input/output device such as a display 454, a communication interface 466, and a transceiver 468, among other components.", "The device 450 may also be provided with a storage device, such as a microdrive or other device, to provide additional storage.", "Each of the components 450, 452, 464, 454, 466, and 468, are interconnected using various buses, and several of the components may be mounted on a common motherboard or in other manners as appropriate.", "The processor 452 may execute instructions within the computing device 640, including instructions stored in the memory 464.The processor may be implemented as a chipset of chips that include separate and multiple analog and digital processors.", "The processor may provide, for example, for coordination of the other components of the device 450, such as control of user interfaces, applications run by device 450, and wireless communication by device 450.Processor 452 may communicate with a user through control interface 648 and display interface 456 coupled to a display 454.The display 454 may be, for example, a TFT LCD (Thin-Film-Transistor Liquid Crystal Display) or an OLED (Organic Light Emitting Diode) display, or other appropriate display technology.", "The display interface 456 may comprise appropriate circuitry for driving the display 454 to present graphical and other information to a user.", "The control interface 458 may receive commands from a user and convert them for submission to the processor 452.In addition, an external interface 462 may be provide in communication with processor 452, so as to enable near area communication of device 450 with other devices.", "External interface 462 may provide, for example, for wired communication in some implementations, or for wireless communication in other implementations, and multiple interfaces may also be used.", "The memory 464 stores information within the computing device 450.The memory 464 may be implemented as one or more of a computer-readable medium or media, a volatile memory unit or units, or a non-volatile memory unit or units.", "Expansion memory 454 may also be provided and connected to device 450 through expansion interface 452, which may include, for example, a SIMM (Single In Line Memory Module) card interface.", "Such expansion memory 454 may provide extra storage space for device 450, or may also store applications or other information for device 450.Specifically, expansion memory 454 may include instructions to carry out or supplement the processes described above, and may include secure information also.", "Thus, for example, expansion memory 454 may be provide as a security module for device 450, and may be programmed with instructions that permit secure use of device 450.In addition, secure applications may be provided via the SIMM cards, along with additional information, such as placing identifying information on the SIMM card in a non-hackable manner.", "The memory may include, for example, flash memory and/or NVRAM memory, as discussed below.", "In one implementation, a computer program product is tangibly embodied in an information carrier.", "The computer program product contains instructions that, when executed, perform one or more methods, such as those described above.", "The information carrier is a computer- or machine-readable medium, such as the memory 464, expansion memory 454, memory on processor 452, or a propagated signal that may be received, for example, over transceiver 468 or external interface 462.Device 450 may communicate wirelessly through communication interface 466, which may include digital signal processing circuitry where necessary.", "Communication interface 466 may provide for communications under various modes or protocols, such as GSM voice calls, SMS, EMS, or MMS messaging, CDMA, TDMA, PDC, WCDMA, CDMA2000, or GPRS, among others.", "Such communication may occur, for example, through radio-frequency transceiver 468.In addition, short-range communication may occur, such as using a Bluetooth, WiFi, or other such transceiver (not shown).", "In addition, GPS (Global Positioning System) receiver module 450 may provide additional navigation- and location-related wireless data to device 450, which may be used as appropriate by applications running on device 450.Device 450 may also communicate audibly using audio codec 460, which may receive spoken information from a user and convert it to usable digital information.", "Audio codec 460 may likewise generate audible sound for a user, such as through a speaker, e.g., in a handset of device 450.Such sound may include sound from voice telephone calls, may include recorded sound (e.g., voice messages, music files, etc.)", "and may also include sound generated by applications operating on device 450.The computing device 450 may be implemented in a number of different forms, as shown in the figure.", "For example, it may be implemented as a cellular telephone 480.It may also be implemented as part of a smartphone 482, personal digital assistant, or other similar mobile device.", "Various implementations of the systems and techniques described here may be realized in digital electronic circuitry, integrated circuitry, specially designed ASICs (application specific integrated circuits), computer hardware, firmware, software, and/or combinations thereof.", "These various implementations may include implementation in one or more computer programs that are executable and/or interpretable on a programmable system including at least one programmable processor, which may be special or general purpose, coupled to receive data and instructions from, and to transmit data and instructions to, a storage system, at least one input device, and at least one output device.", "These computer programs (also known as programs, software, software applications or code) include machine instructions for a programmable processor, and may be implemented in a high-level procedural and/or object-oriented programming language, and/or in assembly/machine language.", "As used herein, the terms “machine-readable medium” “computer-readable medium” refers to any computer program product, apparatus and/or device (e.g., magnetic discs, optical disks, memory, Programmable Logic Devices (PLDs)) used to provide machine instructions and/or data to a programmable processor, including a machine-readable medium that receives machine instructions as a machine-readable signal.", "The term “machine-readable signal” refers to any signal used to provide machine instructions and/or data to a programmable processor.", "To provide for interaction with a user, the systems and techniques described here may be implemented on a computer having a display device (e.g., a CRT (cathode ray tube) or LCD (liquid crystal display) monitor) for displaying information to the user and a keyboard and a pointing device (e.g., a mouse or a trackball) by which the user may provide input to the computer.", "Other kinds of devices may be used to provide for interaction with a user as well; for example, feedback provided to the user may be any form of sensory feedback (e.g., visual feedback, auditory feedback, or tactile feedback); and input from the user may be received in any form, including acoustic, speech, or tactile input.", "The systems and techniques described here may be implemented in a computing system that includes a back end component (e.g., as a data server), or that includes a middleware component (e.g., an application server), or that includes a front end component (e.g., a client computer having a graphical user interface or a Web browser through which a user may interact with an implementation of the systems and techniques described here), or any combination of such back end, middleware, or front end components.", "The components of the system may be interconnected by any form or medium of digital data communication (e.g., a communication network).", "Examples of communication networks include a local area network (“LAN”), a wide area network (“WAN”), and the Internet.", "The computing system may include clients and servers.", "A client and server are generally remote from each other and typically interact through a communication network.", "The relationship of client and server arises by virtue of computer programs running on the respective computers and having a client-server relationship to each other.", "While this disclosure includes some specifics, these should not be construed as limitations on the scope of the disclosure or of what may be claimed, but rather as descriptions of features of example implementations of the disclosure.", "Certain features that are described in this disclosure in the context of separate implementations can also be provided in combination in a single implementation.", "Conversely, various features that are described in the context of a single implementation can also be provided in multiple implementations separately or in any suitable subcombination.", "Moreover, although features may be described above as acting in certain combinations and even initially claimed as such, one or more features from a claimed combination can in some cases be excised from the combination, and the claimed combination may be directed to a subcombination or variation of a subcombination.", "Similarly, while operations are depicted in the drawings in a particular order, this should not be understood as requiring that such operations be performed in the particular order shown or in sequential order, or that all illustrated operations be performed, to achieve desirable results.", "In certain circumstances, multitasking and parallel processing may be advantageous.", "Moreover, the separation of various system components in the implementations described above should not be understood as requiring such separation in all implementations, and it should be understood that the described program components and systems can generally be integrated together in a single software product or packaged into multiple software products.", "Thus, particular implementations of the present disclosure have been described.", "Other implementations are within the scope of the following claims.", "For example, the actions recited in the claims can be performed in a different order and still achieve desirable results.", "A number of implementations have been described.", "Nevertheless, it will be understood that various modifications may be made without departing from the spirit and scope of the disclosure.", "For example, various forms of the flows shown above may be used, with steps re-ordered, added, or removed.", "Accordingly, other implementations are within the scope of the following claims." ] ]
Patent_15875996
[ [ "INFORMATION PROCESSING APPARATUS, METHOD FOR CONTROLLING THE SAME, AND STORAGE MEDIUM", "An information processing apparatus having a touch panel display includes a first detection unit configured to detect that an object touches the touch panel display, and a second detection unit configured to detect that the object touches an area of a display item on the touch panel display and then detect that the object moves outside the area of the display item while touching the touch panel display.", "When the display item is in a flick or drag operation detectable area, the information processing apparatus performs control not to carry out processing associated with the display item in response to the detection by the second detection unit." ], [ "1.An information processing apparatus, comprising: a touch panel display which is able to display a first area and a second area; a detection unit configured to detect that an instruction object touches the touch panel display, and configured to detect that the instruction object having been held in contact with the touch panel display is detached therefrom; and a control unit configured to, in a case where the detection unit detects that an instruction object touches an area of a display item on the touch panel display, select the display item which exists in the touched area, wherein the control unit performs control to carry out processing associated with the selected display item in a case where the selected display item is in the first are, the detection unit detects that the instruction object is detached from the touch panel display without a moving distance of the instruction object reaching a predetermined threshold value, and performs control to carry out processing associated with the selected display item in a case where the selected display item is in the first are, the moving distance of the instruction object reaches the predetermined threshold value without detecting, by the detecting unit, that the instruction object is detached from the touch panel display, and wherein the control unit performs control to carry out processing associated with the selected display item in a case where the selected display item is in the second are, the detection unit detects that the instruction object is detached from the touch panel display without the moving distance of the instruction object reaching the predetermined threshold value, and does not perform control to carry out processing associated with the selected display item in a case where the selected display item is in the second are, the moving distance of the instruction object reaches the predetermined threshold value without detecting, by the detection unit, that the instruction object is detached from the touch panel display.", "2.The information processing apparatus according to claim 1, wherein, in a case where the selected display item is in the second are, the moving distance of the instruction object reaches the predetermined threshold value without detecting, by the detecting unit, that the instruction object is detached from the touch panel display, the control unit scrolls the selected display item.", "3.The information processing apparatus according to claim 1, wherein, in a case where the selected display item is in the second are, the moving distance of the instruction object reaches the predetermined threshold value without detecting, by the detecting unit, that the instruction object is detached from the touch panel display, the control unit changes the currently displayed page to another page.", "4.The information processing apparatus according to claim 1, further comprising: a display control unit configured to, in a case where the selected display item is in the second are, the detection unit detects that the instruction object touches the area of the selected display item, indicate in an identifiable manner that the display item is selected, wherein, in a case where the selected display item is in the second are, the moving distance of the instruction object reaches the predetermined threshold value, the display control unit indicates in an identifiable manner that the selection of the display item is canceled.", "5.The information processing apparatus according to claim 1, wherein the first area is an area which can detect a flick operation, and the second area is an area which cannot detect the flick operation.", "6.A control method for controlling an information processing apparatus which has a touch panel display which is able to display a first area and a second area, comprising: detecting that an instruction object touches the touch panel display; detecting that the instruction object having been held in contact with the touch panel display is detached therefrom; selecting, in a case where it is detected that an instruction object touches an area of a display item on the touch panel display, the display item which exists in the touched area; carrying out processing associated with the selected display item in a case where the selected display item is in the first are, it is detected that the instruction object is detached from the touch panel display without a moving distance of the instruction object reaching a predetermined threshold value, and carrying out processing associated with the selected display item in a case where the selected display item is in the first are, the moving distance of the instruction object reaches the predetermined threshold value without detecting that the instruction object is detached from the touch panel display; and carrying out processing associated with the selected display item in a case where the selected display item is in the second are, it is detected that the instruction object is detached from the touch panel display without the moving distance of the instruction object reaching the predetermined threshold value, wherein processing associated with the selected display item is not carried out in a case where the selected display item is in the second are, the moving distance of the instruction object reaches the predetermined threshold value without detecting that the instruction object is detached from the touch panel display.", "7.A non-transitory computer-readable storage medium storing a program for causing a computer to execute a method for controlling an information processing apparatus which has a touch panel display which is able to display a first area and a second area, comprising: detecting that an instruction object touches the touch panel display; detecting that the instruction object having been held in contact with the touch panel display is detached therefrom; selecting, in a case where it is detected that an instruction object touches an area of a display item on the touch panel display, the display item which exists in the touched area; carrying out processing associated with the selected display item in a case where the selected display item is in the first are, it is detected that the instruction object is detached from the touch panel display without a moving distance of the instruction object reaching a predetermined threshold value, and carrying out processing associated with the selected display item in a case where the selected display item is in the first are, the moving distance of the instruction object reaches the predetermined threshold value without detecting that the instruction object is detached from the touch panel display; and carrying out processing associated with the selected display item in a case where the selected display item is in the second are, it is detected that the instruction object is detached from the touch panel display without the moving distance of the instruction object reaching the predetermined threshold value, wherein processing associated with the selected display item is not carried out in a case where the selected display item is in the second are, the moving distance of the instruction object reaches the predetermined threshold value without detecting that the instruction object is detached from the touch panel display." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present disclosure is directed to preventing selection of a display item from being canceled despite the user's intention and to preventing processing associated with a display item from being performed despite the user's intention when a flick or drag operation is performed on the display item.", "According to an aspect of the present disclosure, an information processing apparatus having a touch panel display includes a first detection unit configured to detect that an instruction object touches the touch panel display, a second detection unit configured to detect that the instruction object is moving while touching the touch panel display, and a third detection unit configured to detect that the instruction object having been held in contact with the display is detached therefrom.", "The information processing apparatus further includes a control unit configured to, in a case where the first detection unit detects that an instruction object touches an area of a display item on the touch panel display and then the second detection unit detects that the instruction object is moving while touching the touch panel display, perform control to carry out processing associated with the display item when the third detection unit detects that the instruction object is detached from the touch panel display before a moving distance of the instruction object reaches a predetermined threshold value, and not to perform control to carry out processing associated with the display item when the moving distance of the instruction object reaches the predetermined threshold value before the third detection unit detects that the instruction object is detached from the touch panel display.", "Further features of the present disclosure will become apparent from the following description of exemplary embodiments with reference to the attached drawings." ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application is a Continuation of U.S. application Ser.", "No.", "14/793,442, filed Jul.", "7, 2015, which claims the benefit of priority from Japanese Patent Application No.", "2014-142729 filed Jul.", "10, 2014, which are each hereby incorporated by reference herein in their entireties.", "BACKGROUND OF THE INVENTION Field of the Invention The present disclosure generally relates to information processing and, more particularly, to an information processing apparatus having a touch panel display, a method for controlling the information processing apparatus, and a storage medium.", "Description of the Related Art In recent years, image forming apparatuses having a touch panel display have been commonly used.", "Such an image forming apparatus is provided with various applications such as copy, print, scan, and FAX transmission.", "A user is able to make setting for each application and instruct the apparatus to start processing of each application by performing touch operations on software buttons on the touch panel display.", "Button control on a touch panel display will be described below with reference to FIGS.", "7A to 7D.", "FIG.", "7A illustrates an appearance of the touch panel display.", "The touch panel display includes a touch panel area 701 which is comprised of a liquid crystal display (LCD) and a touch panel stuck thereon.", "The touch panel display further includes software buttons 702 and 703.FIGS.", "7B and 7C are sectional views illustrating the touch panel taken along a line 704 illustrated in FIG.", "7A, and touch operations by the user.", "A section 706 is equivalent to a line 707, and a width 705 of the button 702 in the X direction is equivalent to a button 708.Since the software buttons 702 and 703 on the touch panel display are 2-dimensionally formed, to make determinations in the X and the Y directions, it is necessary to detect a touch position.", "However, since these determinations are similarly handled, one-dimensional representations are used to simplify descriptions in FIGS.", "7B and 7C.", "Generally, there are the following two different cases in button determination: A.", "When the apparatus detects that a button area is pressed by the finger of a user, the apparatus performs processing associated with the pressed button.", "B.", "When the apparatus detects that a button area is pressed by the finger of a user and then the finger is detached from the relevant button area, the apparatus performs processing associated with the pressed button.", "In a case of A, since the button operation by the user is input as soon as the user touches the button, the user can feel a light touch input.", "For example, when a calculator having large buttons is displayed, the feeling of operation can be improved.", "However, in a case of A, even if the user touches a button by mistake, the button operation by the user is input as soon as the button is touched.", "To address this problem, the method in a case of B is used to provide accuracy in button depression.", "Case B is a case which is a subject of exemplary embodiments of the present invention and will be described in detail below.", "FIG.", "7B illustrates a case where the user touches a button area (709) with the finger and then detaches the finger from the button area (710).", "In this case, when the apparatus detects that the finger touches the button area, the relevant button is put in the selection state.", "Then, when the apparatus detects that the finger is detached from the button area, the apparatus performs processing associated with the selected button.", "For example, when a copy button on a menu screen is selected, the screen changes to a copy application setting screen.", "When a color setting button on the copy application setting screen is selected, the screen changes to a color setting screen.", "FIGS.", "7C and 7D illustrate a case where the user touches a button area (711) with the finger, moves the finger outside the button area while keeping it in contact with the button area, and then detaches the finger (712).", "In this case, when the apparatus detects that the finger has been moved outside the button area as illustrated in FIG.", "7C, the button selection is canceled.", "Therefore, if the user presses a button by mistake, the user is able to cancel execution of processing associated with the button by moving the finger out of the button area while keeping it in contact with the button area, and then detaching the finger.", "However, in a case of a small-sized button such as the button 703, the user's finger may be moved out of the button area by slight motion of the finger although the user thinks the finger is detached from the button area after touching the button inside the button area.", "As a result, the execution of processing associated with the button will be canceled despite the user's intention.", "To solve such a problem, an image forming apparatus performs control in the following way.", "When the apparatus detects that the finger of a user touches a button area and then the finger is moved out of the button area, the apparatus performs processing associated with the button as illustrated in FIG.", "7D.", "By performing such control, even if the user operates a small-sized button, the execution of processing associated with the button can be prevented from being canceled despite the user's intention.", "Lately, some image forming apparatuses have a touch panel display supporting flick operations.", "A flick operation refers to an operation in which the user quickly flips the surface of the touch panel display with the finger.", "Japanese Patent Application Laid-Open No.", "2011-210009 discusses an image forming apparatus which is provided with a plurality of applications such as copy and print, and displays a menu screen arranging icons for selecting applications to be used.", "Japanese Patent Application Laid-Open No.", "2011-210009 discusses a technique for smoothly scrolling the screen with a flick operation to change pages when icons do not fit into one page of the menu screen, so that the user can select an arbitrary application out of the plurality of applications provided by the image forming apparatus.", "However, when it is enabled to perform flick operations in an image forming apparatus which performs button control as illustrated in FIG.", "7D, the following problems will arise.", "More specifically, in a case where the user performs the flick operation in a button area, processing associated with the button will be performed when the user moves the finger out of the relevant button area.", "As a result, although the user performs a flick operation to change a page, processing associated with the button will be performed despite the user's intention.", "Such a problem is not limited to a button, and may commonly arise with any display item which is scrollable by a flick or drag operation and is associated with processing to be performed when pressed by the user.", "SUMMARY OF THE INVENTION The present disclosure is directed to preventing selection of a display item from being canceled despite the user's intention and to preventing processing associated with a display item from being performed despite the user's intention when a flick or drag operation is performed on the display item.", "According to an aspect of the present disclosure, an information processing apparatus having a touch panel display includes a first detection unit configured to detect that an instruction object touches the touch panel display, a second detection unit configured to detect that the instruction object is moving while touching the touch panel display, and a third detection unit configured to detect that the instruction object having been held in contact with the display is detached therefrom.", "The information processing apparatus further includes a control unit configured to, in a case where the first detection unit detects that an instruction object touches an area of a display item on the touch panel display and then the second detection unit detects that the instruction object is moving while touching the touch panel display, perform control to carry out processing associated with the display item when the third detection unit detects that the instruction object is detached from the touch panel display before a moving distance of the instruction object reaches a predetermined threshold value, and not to perform control to carry out processing associated with the display item when the moving distance of the instruction object reaches the predetermined threshold value before the third detection unit detects that the instruction object is detached from the touch panel display.", "Further features of the present disclosure will become apparent from the following description of exemplary embodiments with reference to the attached drawings.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates a hardware configuration of an image forming apparatus according to exemplary embodiments of the present invention.", "FIGS.", "2A, 2B, and 2C illustrate examples of a custom menu screen displayed on a display of the image forming apparatus according to exemplary embodiments of the present invention.", "FIG.", "3 illustrates an example of a copy application setting screen displayed on the display of the image forming apparatus according to exemplary embodiments of the present invention.", "FIGS.", "4A and 4B illustrate problems of the present invention.", "FIG.", "5 is a flowchart illustrating operations of an image forming apparatus according to a first exemplary embodiment.", "FIG.", "6 is a flowchart illustrating operations of an image forming apparatus according to a second exemplary embodiment.", "FIGS.", "7A, 7B, 7C, and 7D illustrate button control on a touch panel display.", "DESCRIPTION OF THE EMBODIMENTS Various exemplary embodiments, features, and aspects of the disclosure will be described in detail below with reference to the drawings.", "A first exemplary embodiment will be described below.", "FIG.", "1 illustrates a hardware configuration of an image forming apparatus 101 to which each exemplary embodiment of the present invention is applicable.", "A central processing unit (CPU) 111, a random access memory (RAM) 112, a read only memory (ROM) 113, an input unit 114, a display control unit 115, an external memory interface (I/F) 116, a printer I/F 117, a scanner I/F 118, and a communication I/F controller 119 are connected to a system bus 110.Further, a touch panel 120, a display 121, an external memory 122, a printer 123, and a scanner 124 are connected to the system bus 110.Each unit connected to the system bus 110 is configured to enable transmitting and receiving data to/from other units via the system bus 110.As used herein, the term “unit” generally refers to any combination of software, firmware, hardware, or other component, such as circuitry, that is used to effectuate a purpose.", "The ROM 113, a nonvolatile memory, stores in respective predetermined areas image data, non-image data, and various programs for operation to be executed by the CPU 111.The RAM 112, a volatile memory, is used as a main memory for the CPU 111 and a temporary storage area such as a work area.", "The CPU 111 controls each unit of the image forming apparatus 101, for example, according to a program stored in the ROM 113 by using the RAM 112 as a work memory.", "Programs for operation to be executed by the CPU 111 are not necessarily stored in the ROM 113 and may be prestored in the external memory 122, such as a hard disk.", "The input unit 114 receives a user operation, generates a control signal according to the operation, and supplies the control signal to the CPU 111.For example, the input unit 114 includes the touch panel 120 as an input device for receiving the user operation.", "The touch panel 120 is an input device for outputting coordinates information, for example, according to a touched position on the planarly configured input unit 114.Based on the control signal generated and supplied in response to the user operation performed on the input device, the CPU 111 controls each unit of the image forming apparatus 101 according to programs.", "Thus, the CPU 111 is able to instruct the image forming apparatus 101 to perform an operation in response to the user operation.", "The display control unit 115 outputs a display signal for displaying an image to the display 121.For example, a display control signal generated by the CPU 111 according to a program is supplied to the display control unit 115.The display control unit 115 generates a display signal based on the display control signal, and outputs the display signal to the display 121.For example, based on the display control signal generated by the CPU 111, the display control unit 115 displays a graphical user interface (GUI) screen on the display 121.The touch panel 120 is configured integrally with the display 121 to function as a touch panel display.", "For example, the touch panel 120 is configured so that transmissivity of light does not disturb display of the display 121, and is arranged on the upper layer of the display surface of the display 121.The input coordinates on the touch panel 120 are associated with the display coordinates on the display 121.Thus, a GUI can be configured to allow an operation as if the user directly operates the screen displayed on the display 121.The touch panel 120 may be any type, such as resistance film type, capacitance type, surface acoustic wave type, infrared-ray type, electromagnetic induction type, image recognition type, and optical sensor type.", "The external memory 122, such as a hard disk, a compact disc (CD), a digital versatile disc (DVD), and a memory card, can be attached to the external memory I/F 116.Under the control of the CPU 111, the external memory I/F 116 writes and reads data to/from the attached external memory 122.The printer 123 is connected to the printer I/F 117.Under the control of the CPU 111, image data to be printed by the printer 123 is transmitted to the printer 123 via the printer I/F 117 and then printed on a recording medium by the printer 123.The scanner 124 is connected to the scanner I/F 118.Under the control of the CPU 111, the scanner 124 reads an image on a document to generate image data.", "The generated image data is stored in the RAM 112 and the ROM 113 via the scanner I/F 118.When the printer 123 performs printing based on the image data generated by the scanner 124, the copy function is achieved.", "Under the control of the CPU 111, the communication I/F controller 119 performs communication with a network 102, such as a local area network (LAN), the Internet, and other wired and wireless networks.", "For example, image data generated by the scanner 124 can be transmitted to the outside via the network 102, and image data received from the outside via the network 102 can be printed by the printer 123.The CPU 111 is able to detect, for example, the following operations and states of the touch panel 120: having touched the touch panel with the finger or pen (object) (hereinafter referred to as a “touch-down”), moving the finger or pen while keeping it in contact with the touch panel (hereinafter referred to as a “move”), a state where the finger or pen is held in contact with the touch panel (hereinafter referred to as a “touch-on”), and detaching the finger or pen from the touch panel (hereinafter referred to as a “touch-up”).", "The CPU 111 is further able to detect a touch-down in a software button area displayed on the display 121 and then detect that the finger or pen is moved out of the software button area while being held in contact with the touch panel (herein after referred to as an “exit”).", "The touch panel 120 is a multi-touch detectable touch panel.", "More specifically, even when a touch-down, a touch-on, a move, and a touch-up are performed by a plurality of fingers and pens at the same time, the touch panel 120 is able to detect respective operations and states.", "These operations and coordinates of a position touched by the finger or pen on the touch panel 120 are transferred to the CPU 111 via the system bus 110.The CPU 111 determines operation performed on the touch panel 120 based on the transferred information.", "For a move, the CPU 111 determines the moving direction of the finger or pen on the touch panel 120 based on changes of the position coordinates for each of the vertical and the horizontal components on the touch panel 120.FIGS.", "2A, 2B, 2C, and 3 illustrate screens displayed on the display 121 of the image forming apparatus 101.The image forming apparatus 101 is provided with a copy function of optically reading an image of a document of a paper medium, converting the image into electronic data, performing image processing on the data, and printing the data on another paper medium.", "The image forming apparatus 101 is further provided with a “scan and send” function (send function) of transmitting the read electronic data to other apparatuses via the network 102.The image forming apparatus 101 is further provided with a “scan and store” function (box function) of storing the read electronic data in the external memory 122.The image forming apparatus 101 is further provided with a web browser function of arranging and displaying a Hyper Text Markup Language (HTML) contents acquired from an external server via the network 102.The image forming apparatus 101 independently stores the above-described functions as different applications in the ROM 113.The CPU 111 executes a required application according to a user's operation.", "FIGS.", "2A to 2C illustrate custom menu screens displayed on the display 121.The custom menu refers to a function of storing setting values of applications, displaying application buttons on a screen, and, when an application button is pressed, reproducing stored setting values and displaying a relevant application screen.", "Referring to FIG.", "2A, a button display area 201 displays application buttons for invoking different applications.", "Each of the application buttons displayed in the button display area 201 is associated with each application provided by the image forming apparatus 101 and relevant setting values.", "When the user presses an application button displayed in the button display area 201, the application screen associated with the relevant button is displayed and setting values associated with the button are reflected therein.", "Further, the application buttons displayed in the button display area 201 can also be associated with user information authenticated through user authentication.", "A title and a comment can be set to each application button displayed in the button display area 201.The user who registers the button is able to arbitrarily set the title and the comment.", "For example, a title “Copy” and a comment “Two-sided, 2 Copies” are displayed on a button 202.More specifically, each button displays an application name and an icon associated with the button, and a title and a comment regarding the setting values.", "The button 202 is associated with a copy application and associated with setting values for two-sided printing and 2 copies.", "When the user selects the button 202, the screen illustrated in FIG.", "3 (described below) is displayed.", "A my button 203 is used to display only application buttons associated with the currently authenticated user in the button display area 201.A shared button 204 is used to display only application buttons associated with all users, i.e., application buttons usable by all users in the button display area 201.A page position display mark 205 schematically represents each page with a circle mark, indicating that a plurality of pages is virtually arranged in the horizontal direction.", "In this case, the page position display marks 205 indicate that the custom menu includes 3 pages and that the currently displayed screen is the first page (the page virtually arranged at the leftmost position).", "The button display area 201 includes page change buttons 206 and 207.The page change button 206 is used to indicate change to the page virtually arranged to the right of the currently displayed page.", "The page change button 207 is used to indicate change to the page virtually arranged to the left of the currently displayed page.", "If there exists no page to the right or left of the currently displayed page, the page change button 206 or 207 is displayed in grayout (disabled).", "For example, referring to FIG.", "2A, the button 207 is displayed in grayout because there exists no page to the left of the currently displayed page.", "When the user presses the page change button 206 on the screen illustrated in FIG.", "2A, the application button list in the button display area 201 scrolls to the left (see FIG.", "2B) and the screen illustrated in FIG.", "2C is displayed.", "On the screen illustrated in FIG.", "2C, the page position display mark 205 indicating the currently displayed page has been moved to the middle, which indicates that the second page is currently displayed.", "The custom menu screens illustrated in FIGS.", "2A to 2C further include a flick operation detectable area 208 in which a flick or drag operation by the user can be detected.", "A flick operation is an operation in which the user quickly moves the finger while keeping it in contact with the touch panel over a predetermined distance and then detaches the finger.", "In other words, the user flips the surface of the touch panel with a quick movement of the finger.", "When the CPU 111 detects a touch-down in the flick operation detectable area 208, a move at a predetermined speed or faster over a predetermined distance or longer, and then a touch-up, the application button list scrolls following the finger motion and then the page changes.", "A drag operation is an operation to move the finger over a predetermined distance or longer keeping it in contact with the touch panel.", "When the CPU 111 detects a touch-down in the flick operation detectable area 208, a move over a predetermined distance or longer, and then a touch-on, the application button list scrolls following the finger motion and then the page changes.", "For example, when the user performs a flick operation from right to left in the flick operation detectable area 208 on the screen illustrated in FIG.", "2A, the application button list scrolls to the left (see FIG.", "2B) and the screen illustrated in FIG.", "2C is displayed.", "When the user performs a flick operation from left to right in the flick operation detectable area 208 on the screen illustrated in FIG.", "2C, the application button list scrolls to the right and the screen illustrated in FIG.", "2A is displayed.", "FIG.", "3 illustrates a copy application setting screen displayed when the button 202 illustrated in FIG.", "2A is selected.", "An icon 301 indicates setting of two-sided printing.", "An icon 302 indicates that the number of copies is set to 2.The copy application setting screen illustrated in FIG.", "3 is a screen in which a flick or drag operation by the user is not detectable.", "Therefore, even if the user performs a flick or drag operation on the screen illustrated in FIG.", "3, buttons are not scrolled and the screen is not changed.", "Thus, screens displayed on the image forming apparatus 101 include screens having an area in which a flick operation is detectable (hereinafter simply referred to as a flickable area) and screens having only an area in which a flick operation is not detectable.", "Button control on the touch panel display on the image forming apparatus 101 will be described in detail below.", "On the copy application setting screen illustrated in FIG.", "3, when a touch-down is detected in a button area, the relevant button is put into a selection state (for example, the button is highlighted), as illustrated in FIG.", "7B.", "When a touch-up is detected inside the button area, processing associated with the selected button is performed.", "Further, on the copy application setting screen illustrated in FIG.", "3, button control as illustrated in FIG.", "7C is not performed but button control as illustrated in FIG.", "7D is performed.", "More specifically, when a touch-down is detected in a button area, the relevant button is put into the selection state.", "Then, when a move is detected and an exit is subsequently detected, processing associated with the selected button is performed.", "Also in each application screen (“scan and send”, “scan and store”, “web browser”, etc.", "), similar button control to the one illustrated in FIG.", "3 is performed.", "Meanwhile, when similar button control is performed on the custom menu screen illustrated in FIGS.", "2A to 2C, a problem may arise when a flick or drag operation is performed.", "FIGS.", "4A and 4B illustrate the relevant problem.", "Referring to FIG.", "4A, the user performs a flick operation to change pages.", "In this case, if the starting position of the flick operation (a touch-down detection position 401) is outside a button area, the application button list is scrolled according to the user's intention and the page is changed.", "On the other hand, if the starting position of the flick operation is in a button area, the button is put into the selection state (an application button 402 is highlighted in FIG.", "4A) when a touch-down is detected.", "Then, when the user's finger is moved by a flick operation 403 outside the button area, an exit is detected and processing associated with the application button 402 will be performed.", "As a result, the screen will be changed to the copy application setting screen illustrated in FIG.", "4B despite the user's intention to change pages in the custom menu screen.", "A similar problem occurs not only in a flick operation but also in a drag operation.", "The image forming apparatus 101 according to the present exemplary embodiment performs control not to execute processing associated with the selected button even when a touch-down is detected in a button area in the flickable area, and an exit is subsequently detected.", "This enables preventing processing associated with the selected button from being performed despite the user's intention when the user performs a flick operation to change pages.", "When an exit is detected, processing associated with the relevant button is not performed and the button selection is not canceled.", "The button selection is canceled when a move is detected, i.e., when the CPU 111 detects that the finger moves over a predetermined distance in the horizontal direction (X direction) from the touch-down detection position.", "The purpose of performing such control will be described below.", "For example, when operating a button having a comparatively small size such as the page change buttons 206 and 207, the finger may be moved outside the button area by slight motion of the finger although the user thinks the finger is placed inside the button area and then is detached from the relevant button area.", "In this case, if the button selection is canceled when an exit is detected, the execution of processing is canceled despite the user's intention and the page will not be changed.", "Therefore, with the above-described control, even if the finger is placed inside the button area and then moved outside the button area, processing associated with the selected button is performed as long as the operation is a move within a distance shorter than the predetermined distance.", "This enables achieving button control reflecting the user's intention.", "FIG.", "5 is a flowchart performed by the image forming apparatus 101 when a touch operation is performed on the touch panel 120 by the user.", "Each step of the flowchart illustrated in FIG.", "5 is implemented when the CPU 111 executes a program stored in the ROM 113 or the external memory 122.In step S501, the CPU 111 determines whether a touch-down is detected in a button area.", "When a touch-down is detected outside the button area (NO in step S501), the processing proceeds to the step S515.In step S515, the CPU 111 performs processing for the case where the finger is placed outside the button area.", "For example, when the CPU 111 detects a touch-down a move at a predetermined speed or faster over a predetermined distance or longer, and then a touch-up in the flickable area (see FIG.", "2A), the application button list scrolls following the finger motion and then the page changes.", "On the other hand, when the CPU 111 detects a touch-down outside the flickable area, the CPU 111 performs no specific processing.", "When a touch-down is detected in a button area (YES in step S501), then in step S502, the CPU 111 sets the relevant button in the selection state.", "The display control unit 115 highlights the button in the selection state to enable the user to recognize that the button is selected.", "In step S503, the CPU 111 determines whether the button exists in the flickable area.", "When it is determined that the button does not exist in the flickable area (for example, a button in the copy application setting screen illustrated in FIG.", "3) (NO in step S503), the processing proceeds to step S504.On the other hand, when it is determined that the button exists in the flickable area (for example, a button on the custom menu screen illustrated in FIGS.", "2A to 2C) (YES in step S503), the processing proceeds to step S508.When the CPU 111 detects a touch-up (YES in step S504), then in step S505, the CPU 111 performs processing associated with the selected button.", "Then, the processing exits the flowchart.", "When the CPU 111 does not detect a touch-up (NO in step S504) and detects a move (YES in step S506), then in step S507, the CPU 111 determines whether an exit is detected.", "When the CPU 111 detects an exit (YES in step S507), the processing proceeds to step S505.In step S505, the CPU 111 performs processing associated with the selected button.", "When the CPU 111 detects a move (YES in step S506), does not detect an exit (NO in step S507), and detects a touch-up (YES in step S504), the processing proceeds to step S505.More specifically, even in the case where the user touches the button area with the finger and then the finger is slightly moved, processing associated with the relevant button is performed when the finger is detached from the touch panel 120 as long as the finger is moved within the relevant button area.", "When the CPU 111 detects a touch-up (YES in step S508), then in step S505, the CPU 111 performs processing associated with the selected button.", "When the CPU 111 does not detect a touch-up (NO in step S508) and detects a move (YES in step S509), the processing proceeds to step S510.When the CPU 111 detects an exit (YES in step S510), the processing returns to step S508.More specifically, in the case where a button is in the flickable area, even when the finger is moved outside the button area, processing associated with the selected button is not performed.", "When the CPU 111 does not detect an exit (NO in step S510) and detects that the distance of a move from the touch-down position has reached a predetermined threshold value (YES in step S511), then in step S512, the CPU 111 cancels the button selection.", "The display control unit 115 restores the button in the selection state to the normal display state to enable the user to recognize that the button selection is canceled.", "When the user performs a flick or drag operation to change page, the CPU 111 determines that the distance of a move has reached the predetermined threshold value (YES in step S511).", "In step S513, the CPU 111 determines whether the currently displayed page is to be changed.", "When the CPU 111 determines that the currently displayed page is to be changed (YES in step S513), then in step S514, the CPU 111 performs screen transition as illustrated in FIGS.", "2A to 2C.", "As described above, when a touch-down is detected in a button area on the touch panel display, the image forming apparatus 101 according to the present exemplary embodiment switches button control methods according to whether the button exists in the flickable area.", "More specifically, in the case where a button is in a flick operation undetectable area, the image forming apparatus 101 performs processing associated with the button when the user moves the finger outside the relevant button area.", "On the other hand, in the case where a button is in the flickable area, the image forming apparatus 101 performs control not to perform processing associated with the button when the finger is moved outside the relevant button area.", "Further, in the case where a button is in the flickable area, the image forming apparatus 101 cancels the button selection when the finger moves over a predetermined distance.", "According to the present exemplary embodiment, it is possible to prevent selection of a button from being canceled despite the user's intention and to prevent processing associated with a button from being performed despite the user's intention when the user performs a flick or drag operation on the relevant button.", "In the first exemplary embodiment described above, in a case where a touch-down is detected in a button area in the flickable area, processing associated with the button is not performed when the finger is moved outside the relevant button area.", "In the present exemplary embodiment, in the case where a button is in the flickable area but is not scrollable by a flick or drag operation, processing associated with the button is performed when the finger is moved out of the relevant button area, similar to a button in a flick operation undetectable area.", "Buttons not scrollable by a flick or drag operation are buttons other than the application buttons illustrated in FIGS.", "2A to 2C, i.e., not scrollable buttons are the my button 203, the shared button 204, and the page change buttons 206 and 207.A second exemplary embodiment will be described below mainly with respect to differences from the first exemplary embodiment.", "FIG.", "6 is a flowchart illustrating operations of the image forming apparatus 101 according to the second exemplary embodiment.", "Steps identical to those of the flowchart illustrated in FIG.", "5 are assigned the same step number.", "The flowchart illustrated in FIG.", "6 differs from the flowchart illustrated in FIG.", "5 in that processing in step S601 is added.", "The following descriptions will be made mainly with respect to the difference.", "Similar to the flowchart illustrated in FIG.", "5, each step of the flowchart illustrated in FIG.", "6 is implemented when the CPU 111 executes a program stored in the ROM 113 of the image forming apparatus 101 or the external memory 120.When the button exists in the flickable area (YES in step S503), then in step S601, the CPU 111 determines whether the button is scrollable by a flick or drag operation.", "When the button is scrollable by a flick or drag operation (YES in step S601), the processing proceeds to step S508 and subsequent steps.", "When the button is not scrollable by a flick or drag operation (NO in step S601), the processing proceeds to step S504 and subsequent steps.", "Thus, in the present exemplary embodiment, in the case of a button which is in the flickable area but is not scrollable by a flick or drag operation, processing associated with the button is performed when an exit is detected similar to the case of buttons in a flick operation undetectable area.", "Specifically, when a touch-down is detected in the button area, the image forming apparatus 101 according to the present exemplary embodiment switches button control methods according to whether the relevant button is scrollable by a flick or drag operation.", "More specifically, in the case of a button not scrollable by a flick or drag operation, the image forming apparatus 101 performs control to carry out processing associated with the button when the user subsequently moves the finger outside the button area.", "On the other hand, in the case of a button scrollable by a flick or drag operation, the image forming apparatus 101 performs control not to perform processing associated with the button when the finger is subsequently moved outside the button area.", "Then, the image forming apparatus 101 performs control to cancels the button selection when the finger is moved over a predetermined distance.", "It is considered that, when the user performs a flick operation, the user generally performs a direct operation on a scrollable button by touching it, and seldom performs a flick operation on a button not scrollable by a flick operation.", "Therefore, even in the case of a button which is in the flick operation detectable area 208 but is not scrollable, the user's operability can be improved by performing button control similar to button control in a flick operation undetectable area.", "While the present disclosure has specifically been described based on exemplary embodiments, the present disclosure is not limited thereto but can be modified in diverse ways without departing from the spirit and scope thereof.", "Further, parts of the above-described exemplary embodiments may be suitably combined.", "For example, display items which are in a scrollable manner displayed on the touch panel display are not limited to application buttons in the custom menu screen.", "The present disclosure may be applied to buttons which are in a scrollable manner displayed by a flick or drag operation on screens other than the custom menu screen.", "In addition to buttons, the present disclosure is also applicable to images, icons, and any other items, as long as it is in a scrollable manner displayed on a screen, and processing associated with the item is performed when a display item is pressed by the user.", "The present disclosure is applicable not only to display items which scroll in the horizontal direction but also to display items which scroll in the vertical and oblique directions and display items which scroll in all direction.", "Although the above-described exemplary embodiments are described based on the image forming apparatus 101 having a plurality of functions such as a copy function and a scanner function, the present invention is also applicable to an image processing apparatus having only some of these functions.", "The present disclosure may be applied to other information processing apparatuses such as personal computers, personal digital assistants (PDAs) mobile phones, facsimiles, cameras, video cameras, and other image viewers.", "As described above, according to the present exemplary embodiment, it is possible to prevent selection of a display item from being canceled despite the user's intention and, when a flick or drag operation is performed on a displayed item, to prevent processing associated with the display item from being performed despite the user's intention.", "Other Embodiments Embodiment(s) of the present disclosure can also be realized by a computer of a system or apparatus that reads out and executes computer executable instructions (e.g., one or more programs) recorded on a storage medium (which may also be referred to more fully as a ‘non-transitory computer-readable storage medium’) to perform the functions of one or more of the above-described embodiment(s) and/or that includes one or more circuits (e.g., application specific integrated circuit (ASIC)) for performing the functions of one or more of the above-described embodiment(s), and by a method performed by the computer of the system or apparatus by, for example, reading out and executing the computer executable instructions from the storage medium to perform the functions of one or more of the above-described embodiment(s) and/or controlling the one or more circuits to perform the functions of one or more of the above-described embodiment(s).", "The computer may comprise one or more processors (e.g., central processing unit (CPU), micro processing unit (MPU)) and may include a network of separate computers or separate processors to read out and execute the computer executable instructions.", "The computer executable instructions may be provided to the computer, for example, from a network or the storage medium.", "The storage medium may include, for example, one or more of a hard disk, a random-access memory (RAM), a read only memory (ROM), a storage of distributed computing systems, an optical disk (such as a compact disc (CD), digital versatile disc (DVD), or Blu-ray Disc (BD)™), a flash memory device, a memory card, and the like.", "While the present disclosure has been described with reference to exemplary embodiments, it is to be understood that the disclosure is not limited to the disclosed exemplary embodiments.", "The scope of the following claims is to be accorded the broadest interpretation so as to encompass all such modifications and equivalent structures and functions." ] ]
Patent_15875998
[ [ "OFF-AXIS EPITAXIAL LIFT OFF PROCESS", "Embodiments described herein provide processes for forming and removing epitaxial films and materials from growth wafers by epitaxial lift off (ELO) processes.", "In some embodiments, the growth wafer has edge surfaces with an off-axis orientation which is utilized during the ELO process.", "The off-axis orientation of the edge surface provides an additional variable for controlling the etch rate during the ELO process and therefore the etch front may be modulated to prevent the formation of high stress points which reduces or prevents stressing and cracking the epitaxial film stack.", "In one embodiment, the growth wafer is rectangular and has an edge surface with an off-axis orientation rotated by an angle greater than 0° and up to 90° relative to an edge orientation of <110> at 0°." ], [ "1.A method for forming an epitaxial film stack during an epitaxial lift off process, the method comprising: providing a growth wafer diced from a piece of semiconductor material, the growth wafer having a plurality of edge surfaces, wherein none of the plurality of edge surfaces has an orientation that is perpendicular to the crystallographic orientation of the piece of semiconductor material, and wherein none of the plurality of edge surfaces has an orientation that is parallel to the crystallographic orientation of the piece of semiconductor material; growing a sacrificial layer over the growth wafer; forming the epitaxial film stack over the sacrificial layer; and removing the sacrificial layer by an etching process, the etching process including a first etch rate of the sacrificial layer near corners of the plurality of edge surfaces that is different than a second etch rate of the sacrificial layer near sides of the plurality of edge surfaces.", "2.The method of claim 1, wherein the orientation of each of the edge surfaces includes an off-axis orientation that is at an angle greater than 0° and less than 90° with respect to the crystallographic orientation of the piece of semiconductor material, the crystallographic orientation being a <110> crystal lattice orientation.", "3.The method of claim 1, wherein the etching process is a lateral etching process that produces an etch front of a wet etch solution that encompasses the sacrificial layer at an interface of the wet etch solution and the sacrificial layer.", "4.The method of claim 3, wherein the etch front forms substantially octagonal geometry comprising alternating sides of a plurality of side edge fronts and corner edge fronts.", "5.The method of claim 4, wherein the corner edge fronts advance at the first etch rate of the sacrificial layer near the corners of the plurality of edge surfaces and the side edge fronts advance at the second etch rate of the sacrificial layer near the sides of the plurality of edge surfaces.", "6.The method of claim 4, wherein the plurality of side edge fronts and corner edge fronts converge at a center of the sacrificial layer at a same time to complete the removal of the sacrificial layer.", "7.The method of claim 3, further comprising: separating the epitaxial film stack from the growth wafer after removal of the sacrificial layer, wherein the geometry of the etch front of the sacrificial layer transitions during the epitaxial lift off process from a substantially rectangular geometry, to a substantially octagonal geometry, and then to a substantially rounded geometry.", "8.The method of claim 3, wherein the sacrificial layer has a rectangular geometry and comprises side edges and corners prior to being exposed to the wet etch solution.", "9.The method of claim 1, wherein the growth wafer is diced from the piece of semiconductor material at an angle that is 45° and corresponds to an off-axis orientation of the growth wafer relative to the wafer.", "10.The method of claim 1, wherein the first etch rate is 1.4 times the second etch rate.", "11.The method of claim 1, wherein the first etch rate is faster than the second etch rate.", "12.The method of claim 1, wherein each edge surface of the growth wafer is oriented in a direction other than that of a cleavage plane of the piece of semiconductor material that is indicative of the crystallographic orientation of the piece of semiconductor material.", "13.The method of claim 1, wherein providing the growth wafer includes dicing the growth wafer from the piece of semiconductor material.", "14.The method of claim 1, wherein the piece of semiconductor material is a gallium arsenide (GaAs) wafer.", "15.A growth wafer comprising: a single-crystal substrate; a crystalline lattice structure; a front face, a bottom face, and side edges extending between the front and bottom faces and the front and bottom faces; a facial surface with an orientation of <001>, off by up to 12°.", "16.The growth wafer of claim 15, wherein the off-axis orientation is rotated by an angle from 0° to 90°.", "17.The growth wafer of claim 15, wherein the off-axis orientation is rotated by an angle from about 30° to 60°.", "18.In an epitaxial lift off process, a sacrificial layer having edges and corners, wherein the corner edge fronts are etched faster than the side edges.", "19.The sacrificial layer of claim 18, wherein the edges are off-axis.", "20.The sacrificial layer of claim 18, wherein the edges are approximately 30-60 degrees from a natural cleave plane." ], [ "<SOH> BACKGROUND <EOH>One phase in device fabrication involves handling and packaging of thin films used in photovoltaic, semiconductor, or other devices.", "Such thin film devices may be manufactured by utilizing a variety of processes for depositing and removing materials onto a wafer or other substrate.", "FIG.", "1 shows a typical wafer 101 that is used as a growth substrate.", "Wafer 101 has a flat cut 103 which indicates its crystallographic orientation.", "This wafer is typically diced into a rectangular or square configuration 105 .", "An edge of the rectangle or square 105 aligns with that of a flat cut 103 .", "The edges of the rectangle or square 105 are either parallel or perpendicular to flat cut 103 .", "This is referred to as an “on-axis” orientation.", "One common technique for manufacturing thin film devices is known as the epitaxial lift off (ELO) process.", "In an ELO process, an epitaxial material or film, often containing multiple layers, is formed on a sacrificial layer which is deposited on the growth wafer.", "The sacrificial layer is etched away and the epitaxial film is separate from the growth wafer.", "The isolated thin epitaxial film may then be further processed and incorporated into a final product, such as in photovoltaic, semiconductor, or other devices.", "The sacrificial layer is typically very thin and is usually etched away via a wet chemical process.", "The speed of the overall process may be limited by the lack of delivery or exposure of reactant to the etch front, which leads to less removal of by products from the etch front.", "The etching process is partially a diffusion limited process, and if the films were maintained in their deposited geometries, a very narrow and long opening would form to severely limit the overall speed of the process.", "To lessen the transport constraint of the diffusion processes, it may be beneficial to open up the resulting gap created by the etched or removed sacrificial layer and bending the epitaxial film away from the growth wafer.", "A crevice is formed between the epitaxial film and growth wafer, providing greater transport of species both towards and away the etch front.", "Reactants move towards the etch front while by-products generally move away from the etch front.", "Furthermore, the epitaxial films grown on nearly rectangular or square growth wafers, or other wafers having sharp angles, are especially susceptible to developing corner cracks during the ELO processes.", "Basically, the diagonal corner regions experience similar or a slightly slower etch rate compared to the straight edges.", "This results in the corners of the sacrificial layer 201 becoming narrower, more pointed and pronounced, as depicted in FIG.", "2 .", "These narrower corners holding down the epitaxial film endure correspondingly increased stresses when the epitaxial film is being separated.", "Therefore, there is a need for a method to remove epitaxial films from the growth wafers without tearing the films during an ELO process, as well as to maintain or increase the throughput of the process." ], [ "<SOH> SUMMARY <EOH>An off-axis epitaxial lift off process is disclosed.", "The growth wafer has edges oriented in a direction other than that of the natural cleavage plane.", "The corners of the growth wafer are etched at a faster rate relative to the edges.", "This results in less stress induced on the corners and thereby reduced corner cracking.", "This increases the yield." ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application is a continuation of U.S. patent application Ser.", "No.", "13/210,138, filed on Aug. 15, 2011, which is incorporated herein its entirety by this reference.", "TECHNICAL FIELD Embodiments of the invention generally relate to epitaxial lift off (ELO) processes.", "BACKGROUND One phase in device fabrication involves handling and packaging of thin films used in photovoltaic, semiconductor, or other devices.", "Such thin film devices may be manufactured by utilizing a variety of processes for depositing and removing materials onto a wafer or other substrate.", "FIG.", "1 shows a typical wafer 101 that is used as a growth substrate.", "Wafer 101 has a flat cut 103 which indicates its crystallographic orientation.", "This wafer is typically diced into a rectangular or square configuration 105.An edge of the rectangle or square 105 aligns with that of a flat cut 103.The edges of the rectangle or square 105 are either parallel or perpendicular to flat cut 103.This is referred to as an “on-axis” orientation.", "One common technique for manufacturing thin film devices is known as the epitaxial lift off (ELO) process.", "In an ELO process, an epitaxial material or film, often containing multiple layers, is formed on a sacrificial layer which is deposited on the growth wafer.", "The sacrificial layer is etched away and the epitaxial film is separate from the growth wafer.", "The isolated thin epitaxial film may then be further processed and incorporated into a final product, such as in photovoltaic, semiconductor, or other devices.", "The sacrificial layer is typically very thin and is usually etched away via a wet chemical process.", "The speed of the overall process may be limited by the lack of delivery or exposure of reactant to the etch front, which leads to less removal of by products from the etch front.", "The etching process is partially a diffusion limited process, and if the films were maintained in their deposited geometries, a very narrow and long opening would form to severely limit the overall speed of the process.", "To lessen the transport constraint of the diffusion processes, it may be beneficial to open up the resulting gap created by the etched or removed sacrificial layer and bending the epitaxial film away from the growth wafer.", "A crevice is formed between the epitaxial film and growth wafer, providing greater transport of species both towards and away the etch front.", "Reactants move towards the etch front while by-products generally move away from the etch front.", "Furthermore, the epitaxial films grown on nearly rectangular or square growth wafers, or other wafers having sharp angles, are especially susceptible to developing corner cracks during the ELO processes.", "Basically, the diagonal corner regions experience similar or a slightly slower etch rate compared to the straight edges.", "This results in the corners of the sacrificial layer 201 becoming narrower, more pointed and pronounced, as depicted in FIG.", "2.These narrower corners holding down the epitaxial film endure correspondingly increased stresses when the epitaxial film is being separated.", "Therefore, there is a need for a method to remove epitaxial films from the growth wafers without tearing the films during an ELO process, as well as to maintain or increase the throughput of the process.", "SUMMARY An off-axis epitaxial lift off process is disclosed.", "The growth wafer has edges oriented in a direction other than that of the natural cleavage plane.", "The corners of the growth wafer are etched at a faster rate relative to the edges.", "This results in less stress induced on the corners and thereby reduced corner cracking.", "This increases the yield.", "BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings are incorporated in and form a part of this specification.", "The drawings illustrate embodiments.", "Together with the description, the drawings serve to explain the principles of the embodiments.", "FIG.", "1 shows a prior art on-axis oriented wafer.", "FIG.", "2 shows a prior art on-axis orientation of a wafer as it is being etched.", "FIG.", "3 shows an off-axis oriented wafer.", "FIG.", "4 shows an off-axis orientation of a wafer as it is being etched.", "DETAILED DESCRIPTION Embodiments described herein provide processes for forming and removing epitaxial films and materials from growth wafers by epitaxial lift off (ELO) processes.", "In some embodiments, the growth wafer has edge surfaces with an off-axis orientation which is utilized during the ELO process.", "Off-axis pertains to the rotation of an edge of the wafer from the nearest <110> orientation.", "The off-axis orientation of the edge surface provides an additional variable for controlling the etch rate during the ELO process—and therefore the etch front may be modulated to prevent the formation of high stress points between the epitaxial film stack and the growth wafer which reduces or prevents stressing and cracking the epitaxial film stack.", "FIG.", "3 shows an off-axis orientation of a wafer 301.The circular wafer 301 has a flat cut 302 that indicates its crystallographic orientation.", "Sometimes a notch will be used to indicate the crystallographic orientation of the circular wafer 301.This circular wafer is diced or cut into a rectangle or square 303, upon which the ELO process is performed.", "Alternatively, a rectangular or square crystal growth wafer 303 is diced out of the crystal boule.", "In other words, the edges of the rectangular or square growth wafer 303 are non-parallel and non-perpendicular to the cleavage plane as identified by the primary flat cut 302 or notch.", "The growth wafer has an edge that is oriented in a direction other than the natural cleavage plane.", "In the currently preferred embodiment, the rectangle or square growth wafer has edges at a 45 degree angle relative to the inherent crystallographic orientation as indicated by the flat cut 302.By dicing the growth wafer at an angle different from that of its natural, inherent crystallographic orientation, the orientation of the growth wafer can be controlled to take advantage of the different etch rates.", "In particular, the area(s) more susceptible to stresses and cracking can be oriented towards the faster etch rates.", "For rectangles and squares, the corners can be oriented to point towards the faster etch fronts.", "FIG.", "4 shows a growth wafer having corners that experience relatively faster etch rates and edges that experience relatively slower etch rates.", "The square growth wafer 401 is off-axis by approximately 45 degrees.", "By virtue of this off-axis configuration, the corners are etched at a faster rate relative to its edges.", "In the currently preferred embodiment, the goal is to have corner etch rate of at least 1.4 times that of the edge etch rate.", "Because the corners are etched away faster, they become more rounded.", "The rounded corners of the sacrificial layer 402 are far more desirable than the narrower, more pointed corners of the prior art because the rounded corners induce less stress during the lift-off process and the epitaxial layer is less susceptible to cracking.", "This improves the yield.", "In embodiment herein, the method includes growing a sacrificial layer over a growth wafer, forming an epitaxial film stack over the sacrificial layer, and exposing the sacrificial layer to a wet etch solution during the ELO process.", "The ELO process includes etching the sacrificial layer, forming a crevice between the growth wafer and the epitaxial film stack, and separating the growth wafer from the epitaxial film stack.", "The ELO etch process is a lateral etch process and the geometry or shape of the etch front may be modulated as a function of multiple variables including the crystalline lattice orientation, etch chemistry (e.g.", "solution composition), etch conditions (e.g., temperature and pressure), and curvature of the crevice (e.g., dynamic clamping).", "The growth wafers described herein have been specifically designed and created in order to have control of the lattice orientation at specified locations on the substrate.", "An off-axis orientation having a predetermined angle may be used to change the etch rate at the corners and sides of the sacrificial layer during the ELO process.", "For example, the off-axis orientation of the growth substrate provides faster etching planes at the corners of the sacrificial layer.", "Therefore, the corners may be etched at a faster rate than the sides of the sacrificial layer in order to provide that the etch front, coming from the corners and sides having corner and side fronts, to converge near the center of the substrate around the same time while forming a singularity between the epitaxial film stack and the growth wafer.", "The growth wafers described herein which have edge surfaces with an off-axis orientation rotated by a predetermined angle may be manufactured or otherwise formed from a variety of different growth wafers.", "A crystalline wafer may contain various elements, including from Groups III, IV, and V, and initially may have a variety of different crystalline orientations.", "In one example, a rectangular growth wafer is cut off-axis from a circular, crystalline, gallium arsenide wafer having a facial orientation of <001>.", "The predetermined angle for the rotated off-axis orientation is measured from the <110> flat.", "The round wafer may be cut with a saw, such as a dice saw, or other cutting or slicing device used to cut crystalline wafers.", "The growth wafer is cut from the round wafer at the predetermined angle relative to the edge flat, such that the previously axis orientation is now rotated by the predetermined angle.", "The predetermined angle is greater than 0° and less than 90°.", "In embodiments herein, the method includes exposing the sacrificial layer to a wet etch solution during the ELO process.", "The ELO process includes etching the sacrificial layer, forming a crevice between the growth wafer and the epitaxial film stack, and separating the growth wafer from the epitaxial film stack.", "In another embodiment, the method further includes forming an etch front by exposing the sacrificial layer to the wet etch solution, wherein the etch front encompasses the sacrificial layer at the interface of the wet etch solution and the sacrificial layer.", "Prior to being exposed to the wet etch solution, the sacrificial layer has side edges and corners which form a rectangular geometry (e.g., rectangle or square).", "Once the sacrificial layer is exposed to the wet etch solution, the etch front advances towards the center of the growth wafer within the crevice while etching the sacrificial layer during the ELO process.", "The etch geometry of the sacrificial layer may be controlled to transitions to have substantially octagonal geometry and then to have substantially rounded geometry.", "The etch front may have a rectangular geometry, conformal to the sacrificial layer when initially exposed.", "However, as the etching process progressed, the etch front generally forms an octagonal geometry containing alternating sides of side edge fronts and corner edge fronts.", "The growth wafer, as described herein having an edge surface with an off-axis orientation rotated by an angle greater than 0° and up to 90°, is utilized to etch the sacrificial layer at the corner edge fronts at a faster etch rate than at the side edge fronts.", "Therefore, the side edge fronts may be longer than the corner edge fronts during an initial duration of the ELO process, but subsequently, the side edge fronts and the corner edge fronts have the same length or substantially the same length during a later duration of the ELO process.", "The geometry of the etch front or the sacrificial layer are controlled and modulated between transitions during the ELO process.", "The geometry of the etch front or the sacrificial layer may transition from a substantially rectangular geometry, to a substantially octagonal geometry, and then to a substantially rounded geometry, such as a rounded singularity.", "In some examples, the substantially octagonal geometry of the etch front or the sacrificial layer transitions from a non-equilateral octagonal geometry to an equilateral or substantially equilateral octagonal geometry.", "From the foregoing, it will be appreciated that specific embodiments of the invention have been described herein for purposes of illustration, but that various modifications may be made without deviating from the scope of the invention.", "Accordingly, the invention is not limited except as by the appended claims." ] ]
Patent_15876001
[ [ "BLOOD PRESSURE METER", "A blood pressure meter includes a pump and a first fluid path provided inside a main body.", "The first fluid path feeds a fluid from the pump to a fluid bladder or discharges the fluid from the fluid bladder.", "A pressure sensor is mounted on a first substrate disposed inside the main body.", "A second fluid path that introduces the fluid from the fluid bladder to the pressure sensor is provided.", "The second fluid path includes an inlet pipe that is integrally formed with a sensor package that incorporates the pressure sensor, and extends straight between the fluid bladder and the pressure sensor.", "A second substrate on which a blood pressure measurement element is mounted is disposed in a space that is located between the first substrate and the fluid bladder in a thickness direction and is adjacent to the second fluid path in a planar direction." ], [ "1.A blood pressure meter that is worn wrapped around a measurement area, the blood pressure meter comprising: a strip-shaped belt that includes a fluid bladder to which a fluid is supplied, and is wrapped around the measurement area; a main body that is provided on an outer surface side of the belt; a pump that is provided inside the main body, and is capable of supplying the fluid to the fluid bladder; a first fluid path that feeds the fluid from the pump to the fluid bladder or discharges the fluid from the fluid bladder; a pressure sensor that is incorporated in a sensor package and mounted on a first substrate disposed inside the main body, and is capable of detecting the pressure in the fluid bladder; and a second fluid path that introduces the fluid from the fluid bladder to the pressure sensor, wherein the second fluid path includes an inlet pipe that is integrally formed with the sensor package as a circumferential wall of the second fluid path, and extends straight between the fluid bladder and the pressure sensor, and wherein a second substrate on which a blood pressure measurement element is mounted is disposed in a space that is located between the first substrate and the fluid bladder in a thickness direction and is adjacent to the second fluid path in a planar direction perpendicular to the thickness direction.", "2.The blood pressure meter according to claim 1, wherein the second substrate includes an escaping portion for allowing the second fluid path to pass therethrough in a plane surface extending along the planar direction.", "3.The blood pressure meter according to claim 1, wherein the pump is disposed at a position adjacent to the first substrate in the planar direction, wherein the first fluid path includes an outlet pipe of the pump as a circumferential wall of the first fluid path, and extends straight between the pump and the fluid bladder in parallel to the second fluid path, and wherein the second substrate extends in a space that is located between the pump and the fluid bladder in the thickness direction and is adjacent to the first fluid path in the planar direction.", "4.The blood pressure meter according to claim 3, wherein the second substrate includes another escaping portion for allowing the first fluid path to pass therethrough in the plane surface extending along the planar direction.", "5.The blood pressure meter according to claim 3, wherein a pump driving circuit for driving the pump is mounted on the second substrate, wherein a region of the second substrate in which the pump driving circuit is mounted is provided to be spaced apart, in the planar direction, from a region of the first substrate in which the pressure sensor is mounted and to oppose the pump, and wherein a lead wire that electrically connects the pump driving circuit and the pump is connected to an end portion of the pump, the end portion being on an opposite side of the pressure sensor in the planar direction.", "6.The blood pressure meter according to claim 1, wherein a control unit that receives an output of the pressure sensor and performs blood pressure calculation processing is mounted on the first substrate, and wherein a region of the first substrate in which the control unit is mounted is provided adjacent to a region of the first substrate in which the pressure sensor is mounted.", "7.The blood pressure meter according to claim 6, wherein at least the region of the first substrate in which the pressure sensor is mounted and the region of the first substrate in which the control unit is mounted are shielded, in the thickness direction, by a display device including a metal plate that is disposed extending outward of the first substrate and the second substrate that is disposed extending inward of the first substrate.", "so as to realize hermetic sealing.", "8.The blood pressure meter according to claim 1, wherein the main body includes a bottom wall between the second substrate and the fluid bladder, the bottom wall including a through cylindrical portion extending in the thickness direction so as to constitute a portion of the circumferential wall of the second fluid path, and wherein the inlet pipe of the pressure sensor and a nipple that is in communication with the fluid bladder are hermetically attached to the cylindrical portion of the bottom wall.", "9.The blood pressure meter according to claim 1, wherein a battery for supplying power to each constituent element of the blood pressure meter is mounted inside the main body, and wherein the battery continuously occupies a range in which at least the first substrate and the second substrate are disposed in the thickness direction.", "10.The blood pressure meter according to claim 9, wherein the first substrate, the pump, the second substrate, and the battery form a rectangular parallelepipedal shaped outer contour as a whole.", "11.The blood pressure meter according to claim 2, wherein the pump is disposed at a position adjacent to the first substrate in the planar direction, wherein the first fluid path includes an outlet pipe of the pump as a circumferential wall of the first fluid path, and extends straight between the pump and the fluid bladder in parallel to the second fluid path, and wherein the second substrate extends in a space that is located between the pump and the fluid bladder in the thickness direction and is adjacent to the first fluid path in the planar direction.", "12.The blood pressure meter according to claim 11, wherein a pump driving circuit for driving the pump is mounted on the second substrate, wherein a region of the second substrate in which the pump driving circuit is mounted is provided to be spaced apart, in the planar direction, from a region of the first substrate in which the pressure sensor is mounted and to oppose the pump, and wherein a lead wire that electrically connects the pump driving circuit and the pump is connected to an end portion of the pump, the end portion being on an opposite side of the pressure sensor in the planar direction." ], [ "<SOH> BACKGROUND ART <EOH>As this type of blood pressure meter, for example, a blood pressure meter as disclosed in Patent Document 1 (JP H09-101220A) is known that includes a pressure sensor module including a tubular inlet pipe integrally formed on a bottom surface of a package incorporating a pressure sensor so as to protrude from the bottom surface.", "The pressure sensor module package is attached onto an upper surface of a circuit substrate, with the inlet pipe extending down to the circuit substrate through a through hole formed in advance in the circuit substrate.", "The inlet pipe is connected to a cuff via an elongated tube (connecting pipe).", "Also, for recent blood pressure meters, in particular, wrist-worn blood pressure meters, there is a growing need to produce miniaturized products.", "For example, Patent Document 2 (JP 2013-220187A) discloses a wrist-worn blood pressure meter in which a fluid bladder enclosed in a blood pressure measurement cuff and a pressure sensor are disposed in a stacked manner in a thickness direction, with a fluid path (corresponding to the inlet pipe described above) being provided in a straight manner between the fluid bladder and the pressure sensor.", "With this configuration, a miniaturized and thinner product is achieved." ], [ "<SOH> SUMMARY OF INVENTION <EOH>However, with the blood pressure meters disclosed in Patent Document 1 (JP H09-101220A) and Patent Document 2 (JP 2013-220187A), there is a relatively large space around the inlet pipe (or the fluid path) in which a component is not disposed.", "Accordingly, there is a possibility that miniaturization of a product, in particular, miniaturization in a planar direction can be further promoted by effectively using the space.", "Thus, one or more embodiments of the present invention provide a blood pressure meter that can promote miniaturization of a product, in particular, miniaturization in a planar direction.", "A blood pressure meter according to one or more embodiments of the present invention is a blood pressure meter that is worn wrapped around a measurement area, the blood pressure meter including: a strip-shaped belt that includes a fluid bladder to which a fluid is supplied, and is wrapped around the measurement area; a main body that is provided on an outer surface side of the belt; a pump that is provided inside the main body, and is capable of supplying the fluid to the fluid bladder; a first fluid path that feeds the fluid from the pump to the fluid bladder or discharges the fluid from the fluid bladder; a pressure sensor that is incorporated in a sensor package and mounted on a first substrate disposed inside the main body, and is capable of detecting the pressure in the fluid bladder; and a second fluid path that introduces the fluid from the fluid bladder to the pressure sensor, wherein the second fluid path includes an inlet pipe that is integrally formed with the sensor package as a circumferential wall of the second fluid path, and extends straight between the fluid bladder and the pressure sensor, and a second substrate on which a blood pressure measurement element is mounted is disposed in a space that is located between the first substrate and the fluid bladder in a thickness direction and is adjacent to the second fluid path in a planar direction perpendicular to the thickness direction.", "In this specification, the term “outer surface” of the strip-shaped belt refers to a surface that is distant from the measurement area.", "Also, the expression “the second fluid path .", ".", ".", "extends straight” means that the second fluid path extends straight so as to include a fluid inlet port of the sensor package and a fluid inlet/outlet port of the fluid bladder in a state in which the sensor package and the fluid bladder are disposed to oppose each other in the thickness direction.", "Also, the term “thickness direction” refers to a direction vertical to an outer circumferential surface of the measurement area, or in other words, a direction through the strip-shaped belt.", "The term “planar direction” refers to a direction in which a surface perpendicular to the thickness direction extends.", "Also, the expression “space that is adjacent to the second fluid path in the planar direction” refers to, for example, the entire area around the second fluid path, or may refer to a space that is on one side of the second fluid path.", "Also, the term “blood pressure measurement element” encompasses, for example, a pump driving circuit for driving the pump, and the like.", "In the blood pressure meter according to one or more embodiments of the present invention, the fluid is fed from the pump provided inside the main body to the fluid bladder through the first fluid path or discharged from the fluid bladder.", "With this configuration, the pressure in the fluid bladder is increased or decreased.", "Also, the pressure of the fluid supplied to the fluid bladder is detected by the pressure sensor (mounted on the first substrate) through the second fluid path.", "Based on the detected pressure, blood pressure values are obtained by using, for example, a known oscillometric method.", "Here, in the blood pressure meter, a second substrate on which a blood pressure measurement element is mounted is disposed in a space that is located between the first substrate and the fluid bladder in a thickness direction and is adjacent to the second fluid path in a planar direction perpendicular to the thickness direction.", "Accordingly, the space that is adjacent to the second fluid path can be effectively used by the second substrate.", "As a result, it is possible to promote miniaturization of the product, in particular, miniaturization in the planar direction.", "To be specific, if a configuration is applied in which the blood pressure measurement element that needs to be mounted on the second substrate is mounted on the first substrate in the absence of the second substrate, there is no option but to increase the dimension of the first substrate in the planar direction accordingly (by an amount corresponding to the increased region where the blood pressure measurement element is disposed).", "However, with the blood pressure meter according to one or more embodiments of the present invention, the space where a component is not disposed in a conventional blood pressure meter can be effectively used by the second substrate.", "As a result, the dimension of the first substrate in the planar direction can be reduced, and miniaturization in the planar direction can be promoted.", "With the blood pressure meter according to the embodiment, the second substrate includes an escaping portion for allowing the second fluid path to pass therethrough in a plane surface extending along the planar direction.", "The “escaping portion” formed in the second substrate may be a through hole extending through the substrate in the thickness direction, or may be a cut-out portion formed in a peripheral edge of the plane surface.", "With the blood pressure meter according to the embodiment, the second substrate includes an escaping portion for allowing the second fluid path to pass therethrough in a plane surface extending along the planar direction.", "Accordingly, the second substrate does not interfere with the second fluid path.", "With the blood pressure meter according to the embodiment, the pump is disposed at a position adjacent to the first substrate in the planar direction, the first fluid path includes an outlet pipe of the pump as a circumferential wall of the first fluid path, and extends straight between the pump and the fluid bladder in parallel to the second fluid path, and the second substrate extends in a space that is located between the pump and the fluid bladder in the thickness direction and is adjacent to the first fluid path in the planar direction.", "In this specification, the expression “the first fluid path .", ".", ".", "extends straight” means that the first fluid path extends straight so as to include a fluid outlet port of the pump and a fluid inlet/outlet port of the fluid bladder in a state in which the pump and the fluid bladder are disposed opposing each other in the thickness direction.", "With the blood pressure meter according to the embodiment, the second substrate extends in a space that is located between the pump and the fluid bladder in the thickness direction and is adjacent to the first fluid path in the planar direction.", "Accordingly, the space that is adjacent to the first fluid path can be effectively used by the second substrate.", "As a result, miniaturization of the product can be further promoted.", "With the blood pressure meter according to the embodiment, the second substrate includes another escaping portion for allowing the first fluid path to pass therethrough in the plane surface extending along the planar direction.", "With the blood pressure meter according to the embodiment, the second substrate includes another escaping portion for allowing the first fluid path to pass therethrough in the plane surface extending along the planar direction.", "Accordingly, the second substrate does not interfere with the first fluid path.", "With the blood pressure meter according to the embodiment, a pump driving circuit for driving the pump is mounted on the second substrate, a region of the second substrate in which the pump driving circuit is mounted is provided to be spaced apart, in the planar direction, from a region of the first substrate in which the pressure sensor is mounted and to oppose the pump, and a lead wire that electrically connects the pump driving circuit and the pump is connected to an end portion of the pump, the end portion being on an opposite side of the pressure sensor in the planar direction.", "With the blood pressure meter according to the embodiment, a region of the second substrate in which the pump driving circuit is mounted is provided to be spaced apart, in the planar direction, from a region of the first substrate in which the pressure sensor is mounted and to oppose the pump.", "Also, a lead wire that electrically connects the pump driving circuit and the pump is connected to an end portion of the pump, the end portion being on an opposite side of the pressure sensor in the planar direction.", "Accordingly, heat generated in the pump driving circuit and the lead wire during driving of the pump is unlikely to be transferred to the pressure sensor.", "As a result, the output of the pressure sensor is unlikely to be affected by the generated heat, and the accuracy of blood pressure measurement is enhanced.", "With the blood pressure meter according to the embodiment, a control unit that receives an output of the pressure sensor and performs blood pressure calculation processing is mounted on the first substrate, and a region of the first substrate in which the control unit is mounted is provided adjacent to a region of the first substrate in which the pressure sensor is mounted.", "With the blood pressure meter according to the embodiment, in the first substrate, a region in which the control unit is mounted is provided adjacent to the region in which the pressure sensor is mounted.", "Accordingly, the interconnect between the pressure sensor and the control unit is relatively short, which makes it unlikely that noise will be included in the output of the pressure sensor.", "As a result, the accuracy of blood pressure measurement is further enhanced.", "With the blood pressure meter according to the embodiment, at least the region of the first substrate in which the pressure sensor is mounted and the region of the first substrate in which the control unit is mounted are shielded, in the thickness direction, by a display device including a metal plate that is disposed extending outward of the first substrate and the second substrate that is disposed extending inward of the first substrate.", "The expression “outward of the first substrate” refers to a side that is distant from the measurement area.", "Likewise, the expression “inward of the first substrate” refers to a side close to the measurement area.", "With the blood pressure meter according to the embodiment, at least the region of the first substrate in which the pressure sensor is mounted and the region of the first substrate in which the control unit is mounted are shielded, in the thickness direction, by a display device including a metal plate that is disposed extending outward of the first substrate and the second substrate that is disposed extending inward of the first substrate.", "Accordingly, this makes it unlikely that noise will be included in the output of the pressure sensor.", "As a result, the accuracy of blood pressure measurement is further enhanced.", "With the blood pressure meter according to the embodiment, the main body includes a bottom wall between the second substrate and the fluid bladder, the bottom wall including a through cylindrical portion extending in the thickness direction so as to constitute a portion of the circumferential wall of the second fluid path, and the inlet pipe of the pressure sensor and a nipple that is in communication with the fluid bladder are hermetically attached to the cylindrical portion of the bottom wall.", "With the blood pressure meter according to the embodiment, the inlet pipe of the pressure sensor and a nipple that is in communication with the fluid bladder are hermetically attached to the cylindrical portion of the bottom wall.", "The second fluid path is thereby constituted.", "Here, if a configuration is applied in which the inlet pipe of the pressure sensor and the nipple that is in communication with the fluid bladder can be directly fitted and attached, stress may be applied to the pressure sensor from the nipple via the inlet pipe and the sensor package during assembly, which may compromise the characteristics of the pressure sensor.", "However, with the blood pressure meter according to the embodiment, the inlet pipe of the pressure sensor and the nipple that is in communication with the fluid bladder are hermetically attached to the cylindrical portion of the bottom wall.", "Accordingly, it is possible to independently perform an operation to attach the inlet pipe of the pressure sensor to the cylindrical portion of the bottom wall and an operation to attach the nipple that is in communication with the fluid bladder to the cylindrical portion of the bottom wall.", "Thus, there is no possibility that the characteristics of the pressure sensor will be compromised due to the application of stress from the nipple during assembly.", "As a result, the reliability of assembly is enhanced.", "With the blood pressure meter according to the embodiment, a battery for supplying power to each constituent element of the blood pressure meter is mounted inside the main body, and the battery continuously occupies a range in which at least the first substrate and the second substrate are disposed in the thickness direction.", "With the blood pressure meter according to the embodiment, the battery continuously occupies a range in which at least the first substrate and the second substrate are disposed in the thickness direction.", "Accordingly, the dimension in the thickness direction of the battery can be configured to be relatively large.", "As a result, it is possible to increase the battery capacity.", "With the blood pressure meter according to the embodiment, the first substrate, the pump, the second substrate, and the battery form a rectangular parallelepipedal shaped outer contour as a whole.", "With the blood pressure meter according to the embodiment, the first substrate, the pump, the second substrate, and the battery form a rectangular parallelepipedal shaped outer contour as a whole.", "That is, these elements are assembled in a compact design.", "As a result, miniaturization of the product is further promoted.", "As is evident from the above description, with the blood pressure meter according to one or more embodiments of the present invention, it is possible to promote miniaturization of the product, in particular, miniaturization in the planar direction." ], [ "TECHNICAL FIELD The present invention relates to a blood pressure meter.", "More specifically, the invention relates to an electronic blood pressure meter that detects the pressure of a fluid supplied to a blood pressure measurement cuff by using a pressure sensor through an inlet pipe that is in communication with the cuff and obtains a blood pressure value based on the detected pressure.", "BACKGROUND ART As this type of blood pressure meter, for example, a blood pressure meter as disclosed in Patent Document 1 (JP H09-101220A) is known that includes a pressure sensor module including a tubular inlet pipe integrally formed on a bottom surface of a package incorporating a pressure sensor so as to protrude from the bottom surface.", "The pressure sensor module package is attached onto an upper surface of a circuit substrate, with the inlet pipe extending down to the circuit substrate through a through hole formed in advance in the circuit substrate.", "The inlet pipe is connected to a cuff via an elongated tube (connecting pipe).", "Also, for recent blood pressure meters, in particular, wrist-worn blood pressure meters, there is a growing need to produce miniaturized products.", "For example, Patent Document 2 (JP 2013-220187A) discloses a wrist-worn blood pressure meter in which a fluid bladder enclosed in a blood pressure measurement cuff and a pressure sensor are disposed in a stacked manner in a thickness direction, with a fluid path (corresponding to the inlet pipe described above) being provided in a straight manner between the fluid bladder and the pressure sensor.", "With this configuration, a miniaturized and thinner product is achieved.", "CITATION LIST Patent Literature Patent Document 1: JP H09-101220A Patent Document 2: JP 2013-220187A SUMMARY OF INVENTION However, with the blood pressure meters disclosed in Patent Document 1 (JP H09-101220A) and Patent Document 2 (JP 2013-220187A), there is a relatively large space around the inlet pipe (or the fluid path) in which a component is not disposed.", "Accordingly, there is a possibility that miniaturization of a product, in particular, miniaturization in a planar direction can be further promoted by effectively using the space.", "Thus, one or more embodiments of the present invention provide a blood pressure meter that can promote miniaturization of a product, in particular, miniaturization in a planar direction.", "A blood pressure meter according to one or more embodiments of the present invention is a blood pressure meter that is worn wrapped around a measurement area, the blood pressure meter including: a strip-shaped belt that includes a fluid bladder to which a fluid is supplied, and is wrapped around the measurement area; a main body that is provided on an outer surface side of the belt; a pump that is provided inside the main body, and is capable of supplying the fluid to the fluid bladder; a first fluid path that feeds the fluid from the pump to the fluid bladder or discharges the fluid from the fluid bladder; a pressure sensor that is incorporated in a sensor package and mounted on a first substrate disposed inside the main body, and is capable of detecting the pressure in the fluid bladder; and a second fluid path that introduces the fluid from the fluid bladder to the pressure sensor, wherein the second fluid path includes an inlet pipe that is integrally formed with the sensor package as a circumferential wall of the second fluid path, and extends straight between the fluid bladder and the pressure sensor, and a second substrate on which a blood pressure measurement element is mounted is disposed in a space that is located between the first substrate and the fluid bladder in a thickness direction and is adjacent to the second fluid path in a planar direction perpendicular to the thickness direction.", "In this specification, the term “outer surface” of the strip-shaped belt refers to a surface that is distant from the measurement area.", "Also, the expression “the second fluid path .", ".", ".", "extends straight” means that the second fluid path extends straight so as to include a fluid inlet port of the sensor package and a fluid inlet/outlet port of the fluid bladder in a state in which the sensor package and the fluid bladder are disposed to oppose each other in the thickness direction.", "Also, the term “thickness direction” refers to a direction vertical to an outer circumferential surface of the measurement area, or in other words, a direction through the strip-shaped belt.", "The term “planar direction” refers to a direction in which a surface perpendicular to the thickness direction extends.", "Also, the expression “space that is adjacent to the second fluid path in the planar direction” refers to, for example, the entire area around the second fluid path, or may refer to a space that is on one side of the second fluid path.", "Also, the term “blood pressure measurement element” encompasses, for example, a pump driving circuit for driving the pump, and the like.", "In the blood pressure meter according to one or more embodiments of the present invention, the fluid is fed from the pump provided inside the main body to the fluid bladder through the first fluid path or discharged from the fluid bladder.", "With this configuration, the pressure in the fluid bladder is increased or decreased.", "Also, the pressure of the fluid supplied to the fluid bladder is detected by the pressure sensor (mounted on the first substrate) through the second fluid path.", "Based on the detected pressure, blood pressure values are obtained by using, for example, a known oscillometric method.", "Here, in the blood pressure meter, a second substrate on which a blood pressure measurement element is mounted is disposed in a space that is located between the first substrate and the fluid bladder in a thickness direction and is adjacent to the second fluid path in a planar direction perpendicular to the thickness direction.", "Accordingly, the space that is adjacent to the second fluid path can be effectively used by the second substrate.", "As a result, it is possible to promote miniaturization of the product, in particular, miniaturization in the planar direction.", "To be specific, if a configuration is applied in which the blood pressure measurement element that needs to be mounted on the second substrate is mounted on the first substrate in the absence of the second substrate, there is no option but to increase the dimension of the first substrate in the planar direction accordingly (by an amount corresponding to the increased region where the blood pressure measurement element is disposed).", "However, with the blood pressure meter according to one or more embodiments of the present invention, the space where a component is not disposed in a conventional blood pressure meter can be effectively used by the second substrate.", "As a result, the dimension of the first substrate in the planar direction can be reduced, and miniaturization in the planar direction can be promoted.", "With the blood pressure meter according to the embodiment, the second substrate includes an escaping portion for allowing the second fluid path to pass therethrough in a plane surface extending along the planar direction.", "The “escaping portion” formed in the second substrate may be a through hole extending through the substrate in the thickness direction, or may be a cut-out portion formed in a peripheral edge of the plane surface.", "With the blood pressure meter according to the embodiment, the second substrate includes an escaping portion for allowing the second fluid path to pass therethrough in a plane surface extending along the planar direction.", "Accordingly, the second substrate does not interfere with the second fluid path.", "With the blood pressure meter according to the embodiment, the pump is disposed at a position adjacent to the first substrate in the planar direction, the first fluid path includes an outlet pipe of the pump as a circumferential wall of the first fluid path, and extends straight between the pump and the fluid bladder in parallel to the second fluid path, and the second substrate extends in a space that is located between the pump and the fluid bladder in the thickness direction and is adjacent to the first fluid path in the planar direction.", "In this specification, the expression “the first fluid path .", ".", ".", "extends straight” means that the first fluid path extends straight so as to include a fluid outlet port of the pump and a fluid inlet/outlet port of the fluid bladder in a state in which the pump and the fluid bladder are disposed opposing each other in the thickness direction.", "With the blood pressure meter according to the embodiment, the second substrate extends in a space that is located between the pump and the fluid bladder in the thickness direction and is adjacent to the first fluid path in the planar direction.", "Accordingly, the space that is adjacent to the first fluid path can be effectively used by the second substrate.", "As a result, miniaturization of the product can be further promoted.", "With the blood pressure meter according to the embodiment, the second substrate includes another escaping portion for allowing the first fluid path to pass therethrough in the plane surface extending along the planar direction.", "With the blood pressure meter according to the embodiment, the second substrate includes another escaping portion for allowing the first fluid path to pass therethrough in the plane surface extending along the planar direction.", "Accordingly, the second substrate does not interfere with the first fluid path.", "With the blood pressure meter according to the embodiment, a pump driving circuit for driving the pump is mounted on the second substrate, a region of the second substrate in which the pump driving circuit is mounted is provided to be spaced apart, in the planar direction, from a region of the first substrate in which the pressure sensor is mounted and to oppose the pump, and a lead wire that electrically connects the pump driving circuit and the pump is connected to an end portion of the pump, the end portion being on an opposite side of the pressure sensor in the planar direction.", "With the blood pressure meter according to the embodiment, a region of the second substrate in which the pump driving circuit is mounted is provided to be spaced apart, in the planar direction, from a region of the first substrate in which the pressure sensor is mounted and to oppose the pump.", "Also, a lead wire that electrically connects the pump driving circuit and the pump is connected to an end portion of the pump, the end portion being on an opposite side of the pressure sensor in the planar direction.", "Accordingly, heat generated in the pump driving circuit and the lead wire during driving of the pump is unlikely to be transferred to the pressure sensor.", "As a result, the output of the pressure sensor is unlikely to be affected by the generated heat, and the accuracy of blood pressure measurement is enhanced.", "With the blood pressure meter according to the embodiment, a control unit that receives an output of the pressure sensor and performs blood pressure calculation processing is mounted on the first substrate, and a region of the first substrate in which the control unit is mounted is provided adjacent to a region of the first substrate in which the pressure sensor is mounted.", "With the blood pressure meter according to the embodiment, in the first substrate, a region in which the control unit is mounted is provided adjacent to the region in which the pressure sensor is mounted.", "Accordingly, the interconnect between the pressure sensor and the control unit is relatively short, which makes it unlikely that noise will be included in the output of the pressure sensor.", "As a result, the accuracy of blood pressure measurement is further enhanced.", "With the blood pressure meter according to the embodiment, at least the region of the first substrate in which the pressure sensor is mounted and the region of the first substrate in which the control unit is mounted are shielded, in the thickness direction, by a display device including a metal plate that is disposed extending outward of the first substrate and the second substrate that is disposed extending inward of the first substrate.", "The expression “outward of the first substrate” refers to a side that is distant from the measurement area.", "Likewise, the expression “inward of the first substrate” refers to a side close to the measurement area.", "With the blood pressure meter according to the embodiment, at least the region of the first substrate in which the pressure sensor is mounted and the region of the first substrate in which the control unit is mounted are shielded, in the thickness direction, by a display device including a metal plate that is disposed extending outward of the first substrate and the second substrate that is disposed extending inward of the first substrate.", "Accordingly, this makes it unlikely that noise will be included in the output of the pressure sensor.", "As a result, the accuracy of blood pressure measurement is further enhanced.", "With the blood pressure meter according to the embodiment, the main body includes a bottom wall between the second substrate and the fluid bladder, the bottom wall including a through cylindrical portion extending in the thickness direction so as to constitute a portion of the circumferential wall of the second fluid path, and the inlet pipe of the pressure sensor and a nipple that is in communication with the fluid bladder are hermetically attached to the cylindrical portion of the bottom wall.", "With the blood pressure meter according to the embodiment, the inlet pipe of the pressure sensor and a nipple that is in communication with the fluid bladder are hermetically attached to the cylindrical portion of the bottom wall.", "The second fluid path is thereby constituted.", "Here, if a configuration is applied in which the inlet pipe of the pressure sensor and the nipple that is in communication with the fluid bladder can be directly fitted and attached, stress may be applied to the pressure sensor from the nipple via the inlet pipe and the sensor package during assembly, which may compromise the characteristics of the pressure sensor.", "However, with the blood pressure meter according to the embodiment, the inlet pipe of the pressure sensor and the nipple that is in communication with the fluid bladder are hermetically attached to the cylindrical portion of the bottom wall.", "Accordingly, it is possible to independently perform an operation to attach the inlet pipe of the pressure sensor to the cylindrical portion of the bottom wall and an operation to attach the nipple that is in communication with the fluid bladder to the cylindrical portion of the bottom wall.", "Thus, there is no possibility that the characteristics of the pressure sensor will be compromised due to the application of stress from the nipple during assembly.", "As a result, the reliability of assembly is enhanced.", "With the blood pressure meter according to the embodiment, a battery for supplying power to each constituent element of the blood pressure meter is mounted inside the main body, and the battery continuously occupies a range in which at least the first substrate and the second substrate are disposed in the thickness direction.", "With the blood pressure meter according to the embodiment, the battery continuously occupies a range in which at least the first substrate and the second substrate are disposed in the thickness direction.", "Accordingly, the dimension in the thickness direction of the battery can be configured to be relatively large.", "As a result, it is possible to increase the battery capacity.", "With the blood pressure meter according to the embodiment, the first substrate, the pump, the second substrate, and the battery form a rectangular parallelepipedal shaped outer contour as a whole.", "With the blood pressure meter according to the embodiment, the first substrate, the pump, the second substrate, and the battery form a rectangular parallelepipedal shaped outer contour as a whole.", "That is, these elements are assembled in a compact design.", "As a result, miniaturization of the product is further promoted.", "As is evident from the above description, with the blood pressure meter according to one or more embodiments of the present invention, it is possible to promote miniaturization of the product, in particular, miniaturization in the planar direction.", "BRIEF DESCRIPTION OF DRAWINGS FIG.", "1A is a top view showing an external appearance of a blood pressure meter 1 according to an embodiment of the present invention.", "FIG.", "1B is a vertical cross-sectional view of the blood pressure meter 1 taken along the line B-B shown in FIG.", "1A.", "FIG.", "1C is a vertical cross-sectional view of the blood pressure meter 1 taken along the line A-A shown in FIG.", "1A.", "FIG.", "2 is a bottom view of the blood pressure meter 1 shown in FIG.", "1.FIG.", "3 is a perspective view of the blood pressure meter 1 shown in FIG.", "1 when it is formed into a loop.", "FIG.", "4 is a diagram illustrating the blood pressure meter 1 shown in FIG.", "3 as viewed from a direction vertical to the loop of the belt.", "FIG.", "5 is an exploded perspective view illustrating a structure of the blood pressure meter 1 shown in FIG.", "1A.", "FIG.", "6A is a schematic perspective view illustrating a first state during operation of a buckle 30 shown in FIG.", "5.FIG.", "6B is a schematic perspective view illustrating a second state during operation of the buckle 30 shown in FIG.", "5.FIG.", "7A is a schematic diagram illustrating a first procedure of wearing the blood pressure meter 1 shown in FIG.", "1 on a wrist and performing measurement.", "FIG.", "7B is a schematic diagram illustrating a second procedure of wearing the blood pressure meter 1 shown in FIG.", "1 on the wrist and performing measurement.", "FIG.", "7C is a schematic diagram illustrating a third procedure of wearing the blood pressure meter 1 shown in FIG.", "1 on the wrist and performing measurement.", "FIG.", "8 is a block diagram schematically showing a configuration of a control system provided inside the blood pressure meter 1 shown in FIG.", "1.FIG.", "9 is a flowchart illustrating blood pressure measurement processing executed by the blood pressure meter 1 shown in FIG.", "1.FIG.", "10A is an enlarged view of a main body assembly 12 shown in FIG.", "5.FIG.", "10B is a bottom view of the main body assembly 12 as viewed from the bottom in FIG.", "10A.", "FIG.", "11 is an exploded view of the main body assembly 12 shown in FIG.", "10A.", "FIG.", "12 is a perspective view showing a positional relationship between a sub-assembly 12′ and a fluid bladder 22 in the assembled blood pressure meter 1.FIG.", "13 is a diagram showing a state in which the sub-assembly 12′ and the fluid bladder 22 shown in FIG.", "12 are spaced apart in a thickness direction (Z direction).", "FIG.", "14 is a ZX cross-sectional view through a pressure sensor 16, showing, in detail, a configuration of a first fluid path 41 and a second fluid path 42 in the blood pressure meter 1, together with a lower housing 13 provided between the sub-assembly 12′ and the fluid bladder 22.FIG.", "15 is a YZ cross-sectional view through the pressure sensor 16, showing, in detail, a configuration of the second fluid path 42 in the blood pressure meter 1, together with the lower housing 13 provided between the sub-assembly 12′ and the fluid bladder 22, so as to realize hermetic sealing.", "FIG.", "16(A) is a diagram showing, in a laid-out state, an upper substrate 61 and a lower substrate 62 that are connected to each other by an FPC cable 63 before the blood pressure meter 1 is assembled, and shows an upper surface 61a of the upper substrate 61 and a lower surface 62b of the lower substrate 62, so as to realize hermetic sealing.", "FIG.", "16(B) is a diagram showing, in a laid-out state, the upper substrate 61 and the lower substrate 62 that are connected to each other by the FPC cable 63 before the blood pressure meter 1 is assembled, and corresponds to the back side of FIG.", "16(A).", "FIG.", "17 is a schematic diagram showing a configuration near the pressure sensor 16 mounted on the upper surface 61a of the upper substrate 61.FIG.", "18 is a schematic diagram showing a configuration near a pressure sensor 16′ mounted on a lower surface 61b of the upper substrate 61.DESCRIPTION OF EMBODIMENTS Hereinafter, an embodiment of the present invention will be described in detail with reference to the drawings.", "In the embodiment given below, the same constituent elements are given the same reference numerals and a description thereof is omitted.", "FIG.", "1A is a top view showing an external appearance of a blood pressure meter 1 according to an embodiment of the present invention.", "FIG.", "1B is a vertical cross-sectional view of the blood pressure meter 1 taken along the line B-B shown in FIG.", "1A.", "FIG.", "1C is a vertical cross-sectional view of the blood pressure meter 1 taken along the line A-A shown in FIG.", "1A.", "FIG.", "2 is a bottom view of the blood pressure meter 1 shown in FIG.", "1.FIG.", "3 is a perspective view of the blood pressure meter 1 shown in FIG.", "1 when the blood pressure meter 1 is worn wrapped around a measurement area.", "FIG.", "4 is a diagram illustrating the blood pressure meter 1 shown in FIG.", "3 as viewed from a direction vertical to the loop of the belt.", "FIG.", "5 is an exploded perspective view illustrating a structure of the blood pressure meter 1 shown in FIG.", "1A.", "As can be seen from FIG.", "3, the blood pressure meter 1 is worn wrapped around a rod-shaped measurement area such as, for example, a user's wrist 90 (see FIGS.", "7A to 7C).", "The blood pressure meter 1 includes a strip-shaped belt 20 that is wrapped around the measurement area, a main body 10 that is disposed in a base end portion a in a lengthwise direction of the belt 20 on an outer surface side of the belt 20 and includes a blood pressure measurement element, and a buckle 30 for joining the base end portion a and a lead end portion b that is provided on the opposite side of the base end portion a in the lengthwise direction of the belt 20 such that the belt 20 forms a loop.", "Here, the belt 20 functions as a blood pressure measurement cuff.", "Hereinafter, a structure of the belt 20 will be described.", "As can be seen from FIG.", "1B, the belt 20 includes a fluid bladder 22 for compressing the measurement area when measuring blood pressure, a reinforcing layer 23 that is provided along an outer surface of the fluid bladder 22 and is for suppressing outward inflation of the fluid bladder 22, and an outer circumferential layer 24 that is provided along an outer surface of the reinforcing layer 23 so as to cover the reinforcing layer 23.Accordingly, because outward inflation of the fluid bladder 22 can be suppressed, it is possible to improve the efficiency of compressing the measurement area and further enhance the accuracy of blood pressure measurement.", "On the other hand, a surface of the fluid bladder 22 (the surface serving as an inner surface when worn) has a plurality of irregularities along the lengthwise direction so as to facilitate inflation toward the measurement area.", "The reinforcing layer 23 is the hardest, followed by the outer circumferential layer 24 and then the fluid bladder 22.Accordingly, the reinforcing layer 23 suppresses outward inflation of the fluid bladder 22 when the fluid bladder 22 is inflated, and thus the efficiency of compressing the measurement area can be improved.", "Accordingly, the accuracy of blood pressure measurement can be further enhanced.", "Furthermore, the outer circumferential layer 24 that is not as hard as the reinforcing layer 23 covers an outer circumference of the reinforcing layer 23, and thus feels soft when the user touches the outer circumferential layer 24 of the belt 20 with his/her hand.", "As can be clearly seen from FIGS.", "1A, 1B, and 3, an operation unit including a blood pressure measurement switch 52B for inputting an instruction to perform a biometric information measurement is disposed in an area (a substantially center portion in this example) that is different from a specific portion (the base end portion a in this example) in which the main body 10 is disposed in the lengthwise direction on the outer surface side of the belt 20.Also, as shown in FIG.", "5, the main body 10 includes a frame-shaped upper housing 11, a lower housing 13 that is combined with the upper housing 11, and a main body assembly 12 that is housed between the upper housing 11 and the lower housing 13.The main body assembly 12 includes a display device 50 that is fitted into the frame of the upper housing 11.A FPC (flexible printed circuit) cable 54 for electrically connecting the main body 10 and the operation unit 5 is provided between the fluid bladder 22 and the reinforcing layer 23.Because the main body 10 and the operation unit 52 are electrically connected by the FPC cable 54 as described above, the belt 20 can be configured to be thin.", "In the present embodiment, only the operation unit is disposed, but the present invention is not limited thereto, and it is also possible to dispose a communication unit and a display unit.", "so as to realize hermetic sealing As can be seen from FIG.", "2, magnets 33 are provided on an inner surface side of the base end portion a of the belt 20, and metal projection portions 31 that are attracted to the magnets 33 are provided on a second plate frame member 30b, thereby constituting an attraction mechanism.", "With this attraction mechanism, the inner surface side of the base end portion a of the belt 20 or one end portion d of a first plate frame member 30a and another end portion h of the second plate frame member 30b are attracted to each other.", "Accordingly, when the main body 10 and the first plate frame member 30a and the second plate frame member 30b of the buckle 30 are folded, an inner surface of the main body 10 and the first plate frame member 30a and the second plate frame member 30b of the buckle 30 are guided to overlap each other.", "In addition to or instead of the attraction mechanism, it is desirable to provide a lock mechanism that engages the inner surface side of the base end portion a of the belt 20 or the one end portion d of the first plate frame member 30a with the other end portion h of the second plate frame member 30b.", "It is also desirable that the attraction mechanism and/or the lock mechanism include/includes an unlock mechanism for releasing the attraction and/or the engagement.", "In this example, a release button 19 (see FIGS.", "1A, 2, and 5) for canceling attraction is provided in the main body 10 as the unlock mechanism.", "As shown in FIG.", "5, the release button 19 is integrally formed with a slide plate 19a.", "In response to the release button 19 being pressed toward the inside of the main body 10, the slide plate 19a is inserted between the one end portion d of the first plate frame member 30a and the other end portion h of the second plate frame member 30b shown in FIG.", "6B like a wedge so as to cancel the attraction between the first plate frame member 30a and the second plate frame member 30b.", "As shown in FIGS.", "6A and 6B, a first fixing element including engaging portions 32 having a projection shape is provided on an inner surface of the other end portion h of the second plate frame member 30b, and also as shown in FIGS.", "1A, 1B, and 5, a second fixing element including engaged portions 25 having a recessed shape that can be engaged with the engaging portions 32 is provided on an outer surface of the lead end portion b of the belt 20.With this configuration, as shown in FIGS.", "3 and 4, the belt 20 can be formed into a loop by engaging the second plate frame member 30b with the lead end portion b of the belt 20.Accordingly, the blood pressure meter 1 can be fixed to the measurement area.", "Furthermore, the second fixing element (the engaged portions 25) that has a non-through recessed shape and is configured to be capable of engaging with the first fixing element (the engaging portions 32) having a projection shape is provided on the outer surface of the lead end portion b of the belt 20, and thus these fixing elements do not interfere with the fluid bladder 22.Accordingly, the wrist 90 that serves as the measurement area can be reliably compressed by the fluid bladder 22 while the blood pressure is being measured.", "The present embodiment is configured such that the first fixing element having a projection shape and the second fixing element having a recessed shape are used, but the present invention is not limited to this configuration.", "It is possible to, for example, use a first fixing element having a recessed shape and a second fixing element having a projection shape.", "In this case as well, the same effects of the present embodiment can be obtained.", "As can be clearly seen from FIGS.", "1A, 1B, and 5, a plurality of engaged portions 25 are formed side by side along the lengthwise direction of the belt 20 such that the attachment position of the other end portion h of the second plate frame member 30b can be adjusted in the lengthwise direction of the belt 20.Accordingly, it is possible to adjust the attachment position of the other end portion h (see FIG.", "6B) of the second plate frame member 30b in the lengthwise direction of the belt 20.With this configuration, the length of the loop of the belt 20 can be variably set so as to fit snug to the circumferential length of the wrist 90 that serves as the measurement area.", "The engaged portions 25 are also arranged in a plurality of (two in this example) rows along a width direction of the belt 20.Accordingly, even if the belt 20 is slightly twisted, the engagement between the engaging portions 32 and the engaged portions 25 is unlikely to be canceled.", "Also, at least the outer surface of the lead end portion b of the belt 20 is made of a flexible material.", "Accordingly, the engagement of the engaging portions 32 and the engaged portions 25 can be easily disengaged.", "It is also possible to provide a detachment mechanism (not shown) that allows the user to cancel the engagement between the engaging portions 32 and the engaged portions 25.In this case, with the detachment mechanism, the user can cancel the engagement between the engaging portions 32 and the engaged portions 25 while the belt 20 is wrapped around the wrist 90.Accordingly, the belt 20 can be more easily detached.", "FIG.", "6A is a schematic perspective view illustrating a first state during operation of the buckle 30 shown in FIG.", "5, and FIG.", "6B is a schematic perspective view illustrating a second state during operation of the buckle 30 shown in FIG.", "5.The buckle 30 includes, on the inner surface side of the base end portion a of the belt 20, the first plate frame member 30a that is attached to the one end portion d so as to be capable of pivoting about an axis c that intersects the lengthwise direction of the belt 20.The first plate frame member 30a extends, in a curved form, from the one end portion d to another end portion e that is on the opposite side.", "The buckle 30 also includes, on the other end portion e of the first plate frame member 30a, the second plate frame member 30b that is attached to one end portion g so as to be capable of pivoting about an axis f that is parallel to the axis c. The second plate frame member 30b extends, in a curved form, from the one end portion g to the other end portion h that is on the opposite side.", "Furthermore, the other end portion h of the second plate frame member 30b is configured to be capable of being attached to the lead end portion b of the belt 20, and the first plate frame member 30a and the second plate frame member 30b respectively have a first opening portion OP1 and a second opening portion OP2 that extend through their plane surfaces.", "Here, the first opening portion OP1 of the first plate frame member 30a and the second opening portion OP2 of the second plate frame member 30b are configured to be continuous in the thickness direction of the main body 10 when the inner surface of the main body 10 and the first plate frame member 30a and the second plate frame member 30b of the buckle 30 are folded so as to overlap each other.", "Accordingly, it is possible to implement a configuration in which the fluid bladder 22 is disposed on the inner side of the main body 10 so as to compress the measurement area.", "The first opening portion OP1 is open toward the other end portion e of the first plate frame member 30a, and the second opening portion OP2 is open toward the one end portion g of the second plate frame member 30b.", "Accordingly, the first opening portion OP1 and the second opening portion OP2 are in communication with each other.", "That is, the first plate frame member 30a and the second plate frame member 30b are formed to have a substantially angular U shape and are joined to each other on the side on which their opening portions are open.", "Also, as can be clearly seen from FIG.", "2, the fluid bladder 22 for compressing the measurement area during blood pressure measurement is provided along the lengthwise direction of the belt 20 in the belt 20, and the fluid bladder 22 is in communication with the inside of the main body 10 through a region corresponding to the first opening portion OP1 and the second opening portion OP2 in a folded state.", "With this configuration, the fluid bladder 22 can compress a spatially continuous region of the wrist 90 that serves as the measurement area in a circumferential direction thereof, the spatially continuous region extending from a portion corresponding to the inside of the main body 10 toward the lead end portion b of the belt 20.Accordingly, the contact area between the fluid bladder 22 and the measurement area can be increased, and it is therefore possible to improve the efficiency of compressing the arteries.", "Accordingly, the accuracy of blood pressure measurement can be further enhanced.", "Also, the fluid bladder 22 extends to the lead end portion b of the belt 20 along the lengthwise direction.", "When the inner surface of the main body 10 and the first plate frame member 30a and the second plate frame member 30b of the buckle 30 are folded so as to overlap each other, a portion of the main body 10 that is in communication with the fluid bladder 22 overlaps a portion to which the fluid bladder 22 of the belt 20 extends.", "With this configuration, the overlapping region of the belt 20 in the lengthwise direction has a thickness thicker than that of the other region of the main body 10 and thus is inflated by an amount corresponding to the thickness.", "Accordingly, an excessive amount of pressure applied to compress the arteries is reduced as a result of reducing the distance by which the arteries running through the wrist 90 escape due to being pressed by a region other than the overlapping region.", "As a result, the blood pressure values measured through the application of pressure by the fluid bladder can be brought closer to true values, and thus the accuracy of measurement can be enhanced.", "The effect of reducing the excessive amount of pressure applied to compress the arteries is also obtained even when the first opening portion OP1 of the first plate frame member 30a and the second opening portion OP2 of the second plate frame member 30b in the buckle 30 are omitted.", "FIGS.", "7A to 7C are schematic diagrams illustrating a procedure of wearing the blood pressure meter 1 shown in FIG.", "1 on the wrist and performing measurement.", "When actually wearing the blood pressure meter 1 on the wrist 90, as shown in FIG.", "7A, the user first places the belt 20 around the wrist 90, with the main body 10 and the first plate frame member 30a and the second plate frame member 30b of the buckle 30 being open.", "Then, the user inserts the lead end portion b of the belt 20 through the second opening portion OP2 (see FIGS.", "6A and 6B) of the second plate frame member 30b and engages the engaging portions 32 of the second plate frame member 30b with the engaged portions 25 that are provided on the lead end portion b of the belt 20.By doing so, the belt 20 is formed into a loop and the wrist 90 passes through the loop of the belt 20.In this way, the length of the loop of the belt 20 can be set so as to fit snug to the circumferential length of the wrist 90.Next, as shown in FIG.", "7B, the main body 10 is moved closer toward the wrist 90 such that the inner surface of the main body 10 and the first plate frame member 30a and the second plate frame member 30b of the buckle 30 are folded so as to overlap each other.", "Then, the projection portions 31 of the second plate frame member 30b are attracted by the magnets 33.The blood pressure meter 1 is thereby worn on the wrist 90.Next, blood pressure measurement starts in response to the user pressing the blood pressure measurement switch 52B as shown in FIG.", "7C.", "FIG.", "8 is a block diagram schematically showing an internal configuration of the blood pressure meter 1 shown in FIG.", "1.The main body 10 includes, in addition to the display device 50 and the operation unit 52 described above, a CPU (central processing unit) 100, a memory 51, a battery 53, a piezoresistive pressure sensor 16, a piezoelectric pump 17 that supplies air to the fluid bladder 22 as a fluid, a valve 18 for adjusting a discharge pressure (back pressure) of the piezoelectric pump 17, an oscillation circuit 160 that converts an output from the pressure sensor 16 to a frequency, a pump driving circuit 170 that drives the piezoelectric pump 17, and a valve driving circuit 180 that drives the valve 18.The piezoelectric pump 17 and the valve 18 are connected to the fluid bladder 22 enclosed in the belt 20 via a first fluid path 41, and the pressure sensor 16 is connected to the fluid bladder 22 enclosed in the belt 20 via a second fluid path 42.With this configuration, air flows between the piezoelectric pump 17 and the fluid bladder 22 and between the valve 18 and the fluid bladder 22 via the first fluid path 41.Also, air flows between the pressure sensor 16 and the fluid bladder 22 via the second fluid path 42.The display device 50 includes a display, an indicator and the like, and displays predetermined information in accordance with a control signal from the CPU 100.In the operation unit 52, a power supply switch 52A receives an instruction to turn on or off power supply from the battery 53.The blood pressure measurement switch 52B receives an instruction to start blood pressure measurement and an instruction to display data obtained through measuring blood pressure values, stored in the memory 51 on the display device 50.The switches 52A and 52B input an operation signal corresponding to a user's instruction to the CPU 100.The memory 51 stores therein a program for controlling the blood pressure meter 1, settings data for setting various functions of the blood pressure meter 1, and data obtained as a result of measurement of blood pressure values.", "Also, the memory 51 is used a work memory during execution of a program.", "In this example, the battery 53 is a secondary battery (lithium ion battery), and supplies power to the CPU 100, the pressure sensor 16, the piezoelectric pump 17, the valve 18, the display device 50, the memory 51, the oscillation circuit 160, the pump driving circuit 170, and the valve driving circuit 180.The battery 53 is configured to be rechargeable via a USB (Universal Serial Bus) terminal 55 (see, for example, FIG.", "10B).", "The CPU 100 functions as a control unit in accordance with the program for controlling the blood pressure meter 1 stored in the memory 51, and performs control for driving the piezoelectric pump 17 via the pump driving circuit 170 and driving the valve 18 via the valve driving circuit 180 in accordance with an operation signal from the operation unit 52.The valve 18 is opened or closed so as to control the pressure (cuff pressure) in the fluid bladder 22 by discharging or trapping air in the fluid bladder 22.Also, the CPU 100 calculates blood pressure values based on signals from the pressure sensor 16 and controls the display device 50 and the memory 51.The piezoelectric pump 17 supplies air to the fluid bladder 22 via the first fluid path 41 so as to increase the pressure (cuff pressure) in the fluid bladder 22 enclosed in the belt 20.The valve 18 is opened or closed so as to control the cuff pressure by discharging the air in the fluid bladder 22 via the first fluid path 41 or trapping air in the fluid bladder 22.The pump driving circuit 170 drives the piezoelectric pump 17 based on a control signal provided from the CPU 100.The valve driving circuit 180 opens or closes the valve 18 based on a control signal provided from the CPU 100.The pressure sensor 16 and the oscillation circuit 160 operate as a pressure detection unit that detects the cuff pressure.", "The pressure sensor 16 is, for example, a piezoresistive pressure sensor, and introduces air from the fluid bladder 22 via the second fluid path 42 and detects the pressure of the introduced air as the cuff pressure.", "In this example, the oscillation circuit 160 oscillates based on an electric signal value that is based on a change in electric resistance due to piezoresistance effect from the pressure sensor 16, and outputs a frequency signal having a frequency corresponding to the electric signal value of the pressure sensor 16 to the CPU 100.In this example, it is assumed that the oscillation circuit 160 is included in the CPU 100, and the function of the oscillation circuit 160 is implemented by a program executed by the CPU 100.Hereinafter, a description will be given of operations performed by the blood pressure meter 1 configured as described above.", "FIG.", "9 is a flowchart of blood pressure measurement processing executed by the blood pressure meter 1 shown in FIG.", "1.In general, the following operations are performed when blood pressure measurement is performed according to an ordinary oscillometric method.", "To be specific, the cuff is wrapped around the measurement area (wrist or the like) of the user in advance, and during measurement, the pump and the valve are controlled to increase the cuff pressure to be higher than the highest blood pressure and thereafter gradually decrease the cuff pressure.", "In the pressure decrease process, the cuff pressure is detected by the pressure sensor, and a variation in arterial volume that occurs in the arteries running through the measurement area is taken as a pulse wave signal.", "The highest blood pressure (systolic blood pressure) and the lowest blood pressure (diastolic blood pressure) are calculated based on changes (mainly a leading edge and a trailing edge) in amplitude of the pulse wave signal due to changes in the cuff pressure at that time.", "In the blood pressure meter 1, the blood pressure values of the user are measured according to an oscillometric method by the CPU 100 in accordance with the flowchart shown in FIG.", "9.To be specific, in response to the blood pressure measurement switch 52B being pressed while the power supply switch 52A is on, as shown in FIG.", "9, the blood pressure meter 1 starts blood pressure measurement.", "Upon starting a blood pressure measurement, the CPU 100 initializes a processing memory area and outputs a control signal to the valve driving circuit 180.The valve driving circuit 180 opens the valve 18 based on the control signal so as to discharge the air in the fluid bladder 22 of the belt 20.Next, control for adjusting the pressure sensor 16 to 0 mmHg is performed.", "In FIG.", "9, when blood pressure measurement starts, first, the CPU 100 closes the valve 18 via the valve driving circuit 180, and after that, drives the piezoelectric pump 17 via the pump driving circuit 170 so as to perform processing to increase pressure to send air to the fluid bladder 22.Accordingly, the fluid bladder 22 is inflated and the cuff pressure is gradually increased (step ST101).", "When the cuff pressure has increased and reaches a predetermined pressure (YES in step ST102), the CPU 100 performs control for stopping the piezoelectric pump 17 via the pump driving circuit 170 and thereafter gradually opening the valve 18 via the valve driving circuit 180.Accordingly, the fluid bladder 22 contracts and the cuff pressure gradually decreases (step ST103).", "As used herein, the predetermined pressure refers to a pressure value that is sufficiently higher than the systolic blood pressure (for example, a systolic blood pressure of +30 mmHg) of the user, and the predetermined pressure is stored in the memory 51 in advance or the CPU 100 determines the predetermined pressure by estimating the systolic blood pressure using a predetermined calculation method while the cuff pressure is increased (see, for example, JP 2001-70263A).", "Also, for the pressure decrease speed, a target pressure decrease speed that is a target is set while the cuff pressure is increased, and the CPU 100 controls the opening degree of the valve 18 so as to reach the target pressure decrease speed (see JP 2001-70263A).", "In the pressure decrease process, the pressure sensor 16 detects a cuff pressure signal (indicated by a reference sign Pc) representing the pressure of the belt 20 via the belt 20.Based on the cuff pressure signal Pc, the CPU 100 calculates the blood pressure values (systolic blood pressure and diastolic blood pressure) by applying an algorithm, which will be described later, using an oscillometric method (step ST104).", "Note that the calculation of the blood pressure values is not limited to being performed in the pressure decrease process, and may be performed in the pressure increase process.", "Upon determining the blood pressure values through calculation (YES in step ST105), the CPU 100 performs control for displaying the calculated blood pressure values on the display device 50 (step ST106) and also performs control for storing the calculated blood pressure values in the memory 51 (step ST107).", "Next, the CPU 100 performs control for opening the valve 18 via the valve driving circuit 180 so as to discharge the air in the fluid bladder 22 of the belt 20 (step ST108).", "After that, in response to the power supply switch 52A being pressed, the blood pressure measurement ends.", "When detaching the blood pressure meter 1 from the wrist 90, the user opens the first plate frame member 30a and the second plate frame member 30b of the buckle 30, and releases the wrist 90 from the belt with the loop of the belt 20 being widened.", "When wearing the blood pressure meter 1 on the wrist 90 for the second time or more, the user can insert the wrist 90 through the loop of the belt 20, with the first plate frame member 30a and the second plate frame member 30b of the buckle 30 being open, and close the buckle 30.Accordingly, the user can easily wear the blood pressure meter 1 on the wrist 90.FIG.", "10A is an enlarged view of the main body assembly 12 shown in FIG.", "5.FIG.", "10B is a bottom view of the main body assembly 12 as viewed from the bottom in FIG.", "10A.", "FIG.", "11 is an exploded view of the main body assembly 12 shown in FIG.", "10A.", "In FIG.", "11, an XYZ orthogonal coordinate system is also shown where a direction (the thickness direction of the main body assembly 12) that is vertical to the outer circumferential surface of the wrist 90 that serves as the measurement area is defined as a Z direction, a direction corresponding to the width direction of the belt 20 is defined as an X direction, and a direction corresponding to the lengthwise direction of the belt 20 is defined as a Y direction (the same applies to FIGS.", "12 to 15, 16(B), 17, and 18, which will be described later).", "As can be clearly seen from FIG.", "11, the main body assembly 12 includes a sub-assembly 12′ that includes, at a substantially center position, an upper substrate 61 that serves as a first substrate and a lower substrate 62 that serves as a second substrate that opposes the upper substrate 61 and is combined with the upper substrate 61 in the Z direction.", "The upper substrate 61 is attached to the lower substrate 62 with a screw 65 or the like via a spacer (not shown in the diagram) so as to provide a fixed spacing with respect to the lower substrate 62 in the Z direction.", "As used herein, the terms “upper substrate” and “lower substrate” (as well as the terms “upper surface” and “lower surface” which will be described later) are used for the sake of the description, and thus are not intended to limit the orientation of the blood pressure meter 1 when in use.", "On the upper substrate 61, the pressure sensor 16, the CPU 100 (including the oscillation circuit 160) and the memory 51 that were described above and an interconnect are mounted (for the sake of simplification, only the pressure sensor 16 is shown in FIG.", "11).", "On the lower substrate 62, the piezoelectric pump 17, the pump driving circuit 170, the valve 18 and the valve driving circuit 180 that were described above and an interconnect are mounted (for the sake of simplification, only the piezoelectric pump 17 and the pump driving circuit 170 are shown in FIG.", "11).", "The interconnect of the upper substrate 61 and the interconnect of the lower substrate 62 are connected to each other by the FPC cable 63.The upper substrate 61 has a dimension in the X direction that is substantially half of the dimension in the X direction of the lower substrate 62.With this configuration, the upper substrate 61 opposes only substantially half of the region of the lower substrate 62 that is on the +X side in the X direction.", "The piezoelectric pump 17 includes a main portion 17p having a rectangular parallelepipedal shaped outer contour, and is mounted on substantially half of the region of the lower substrate 62 that is on the −X side in the X direction.", "The piezoelectric pump 17 is higher than the upper substrate 61, as a result of which, the piezoelectric pump 17 is located at a position adjacent to the upper substrate 61 on the −X side in a planar direction (XY direction).", "Substantially half of the region of the sub-assembly 12′ that is on the −Y side in the Y direction is occupied by a frame-shaped battery holder 53F.", "The battery 53 having a rectangular parallelepipedal shaped outer contour is fitted and attached to the battery holder 53F from the −Z direction.", "As a result, the upper substrate 61, the piezoelectric pump 17, the lower substrate 62, and the attached battery 53 form a rectangular parallelepipedal shaped outer contour as a whole.", "As a result of these elements being assembled in a compact design, it is possible to promote miniaturization of the product.", "The main body assembly 12 further includes a USB substrate 55P attached to an edge portion of the upper substrate 61 that is on the −Y side.", "The USB substrate 55P incorporates a USB terminal 55 and an interconnect (not shown).", "The interconnect of the USB substrate 55P is connected to the interconnect of the upper substrate 61 via an FPC cable 55F.", "Also, the main body assembly 12 includes a plate-like joint member 52G that is attached to an edge portion of the lower substrate 62 that is on the +Y side, and is inclined in the −Z direction.", "The joint member 52G includes two branched tip ends 52G1 and 52G2.A switch substrate 52P incorporating the power supply switch 52A and an interconnect (not shown) is attached so as to straddle the tip ends 52G1 and 52G2.The interconnect of the switch substrate 52P is connected to the interconnect of the lower substrate 62 via an FPC cable 52F.", "Also, the main body assembly 12 includes the substantially flat plate-like display device 50 (an organic EL (electro luminescent) display in this example) that is attached to the outside (on +Z side).", "The display device 50 includes a rectangular frame-shaped glass frame 50e extending along a peripheral edge of the display device 50, and also includes a metal plate 50c on a back surface of the display device 50.Also, an FPC cable 50F is attached to an edge portion of the display device 50 that is on the +Y side.", "The FPC cable 50F passes through a gap 52Gw (see FIG.", "10A) formed between the joint member 52G and the switch substrate 52P, and is connected to the interconnect of the lower substrate 62.As described above, the main body assembly 12 shown in FIGS.", "10A and 10B is configured in a compact and substantially rectangular parallelepipedal shape.", "FIG.", "12 shows a positional relationship between the sub-assembly 12′ and the fluid bladder 22 in the assembled blood pressure meter 1, as viewed obliquely.", "FIG.", "13 shows a state (state before assembly) in which the sub-assembly 12′ and the fluid bladder 22 shown in FIG.", "12 are spaced apart in the Z direction.", "For the sake of ease of understanding, in FIGS.", "12 and 13, the illustration of the lower housing 13 is omitted.", "The fluid bladder 22 includes cylindrical nipples 381 and 382 for allowing air to be supplied into the fluid bladder 22 as a fluid and allowing air to be discharged from the fluid bladder 22.As can be clearly seen from FIG.", "13, the pressure sensor 16 is incorporated in a substantially rectangular parallelepipedal shape sensor package 16p and mounted on the upper surface 61a of the upper substrate 61.In this example, the pressure sensor 16 includes a substantially cylindrical inlet pipe 16d that is integrally molded with the sensor package 16p and lead terminals 16e and 16f that protrude from side surfaces of the sensor package 16p.", "The lead terminals 16e and 16f are connected to the interconnect (not shown) that is provided on the upper substrate 61.The inlet pipe 16d extends straight in the −Z direction from a bottom surface (a surface that is closer to the upper substrate 61) 16b of the sensor package 16p toward the fluid bladder 22 through a through hole 61x that is formed in the upper substrate 61 and a through hole 62x that is formed in the lower substrate 62 and serves as an escaping portion.", "The inlet pipe 16d constitutes a portion of a circumferential wall of the second fluid path 42 described above.", "An O ring 394 for hermetic sealing is press fitted around the inlet pipe 16d.", "The sensor package 16p and the inlet pipe 16d may be formed separately, and integrally jointed with an adhesive or the like.", "The piezoelectric pump 17 is mounted on the lower substrate 62, and, as already described above, is located at a position adjacent to the upper substrate 61 on the −X side in the planar direction (the XY direction).", "The piezoelectric pump 17 includes the main portion 17p having a rectangular parallelepipedal shaped outer contour and a substantially cylindrical outlet pipe 17d integrally molded with the main portion 17p.", "The outlet pipe 17d extends straight in the −Z direction from a bottom surface of the main portion 17p toward the fluid bladder 22 through a through hole 62w that is formed in the lower substrate 62 and that serves as another escaping portion.", "The outlet pipe 17d constitutes a portion of a circumferential wall of the first fluid path 41 described above.", "An O ring 393 for hermetic sealing is press fitted around the outlet pipe 17d.", "As can be clearly seen from FIG.", "12, in the assembled blood pressure meter 1, the nipples 381 and 382 of the fluid bladder 22 are provided around the outlet pipe 17d of the piezoelectric pump 17 and the inlet pipe 16d of the pressure sensor 16 so as to overlap them in the Z direction through the through holes 62w and 62x formed in the lower substrate 62, thereby constituting the first fluid path 41 and the second fluid path 42, respectively.", "The through holes 62w and 62x that are formed in the lower substrate 62 and serve as escaping portions are configured to have an inner diameter slightly larger than the outer diameter of outer circumferential cylindrical portions 391a and 392a of the lower housing 13, which will be described later.", "FIG.", "14 shows, in detail, a configuration of the first fluid path 41 and the second fluid path 42, together with the lower housing 13 provided between the sub-assembly 12′ and the fluid bladder 22, by using a ZX cross-sectional view through the pressure sensor 16.Also, FIG.", "15 shows, in detail, a configuration of the second fluid path 42, together with the lower housing 13 provided between the sub-assembly 12′ and the fluid bladder 22, by using a YZ cross-sectional view through the pressure sensor 16.As can be clearly seen from FIG.", "14, the lower housing 13 includes double cylindrical portions 391 and 392 at positions corresponding to the outlet pipe 17d of the piezoelectric pump 17 and the inlet pipe 16d of the pressure sensor 16, respectively, on a bottom wall 13b of the lower housing 13.The double cylindrical portion 391 includes an outer circumferential cylindrical portion 391a that stands upright from the bottom wall 13b in the +Z direction, an inner circumferential cylindrical portion 391c that is concentric with the outer circumferential cylindrical portion 391a, and extends in the Z direction through the bottom wall 13b, and an annular joint plate portion 391b that is flat and joins an upper edge of the outer circumferential cylindrical portion 391a and an upper edge of the inner circumferential cylindrical portion 391c to each other.", "On the inner circumferential side of the inner circumferential cylindrical portion 391c, an annular engaging plate portion 391f is provided in a protruding manner at a substantially center position in the Z direction so as to reduce the diameter (inner diameter).", "The engaging plate portion 391f has an inner circumferential edge 391e configured to have a diameter (inner diameter) slightly larger than the outer diameter of the outlet pipe 17d of the piezoelectric pump 17.Also, the inner circumferential cylindrical portion 391c is configured to have an inner diameter slightly smaller than the outer diameter of the O ring 393.The inner circumferential cylindrical portion 391c is configured to have an outer diameter slightly larger than the inner diameter of the nipple 381.A radial spacing between the inner circumferential cylindrical portion 391c and the outer circumferential cylindrical portion 391a is configured to be sufficiently larger than the thickness of the nipple 381 of the fluid bladder 22 so as to allow insertion of the nipple 381 of the fluid bladder 22 into the spacing.", "Likewise, the double cylindrical portion 392 includes an outer circumferential cylindrical portion 392a that stands upright from the bottom wall 13b in the +Z direction, an inner circumferential cylindrical portion 392c that is concentric with the outer circumferential cylindrical portion 392a, and extends in the Z direction through the bottom wall 13b, and an annular joint plate portion 392b that is flat and joins an upper edge of the outer circumferential cylindrical portion 392a and an upper edge of the inner circumferential cylindrical portion 392c to each other.", "On the inner circumferential side of the inner circumferential cylindrical portion 392c, an annular engaging plate portion 392f is provided in a protruding manner at a substantially center position in the Z direction so as to reduce the diameter (inner diameter).", "The engaging plate portion 392f has an inner circumferential edge 392e configured to have a diameter (inner diameter) slightly larger than the outer diameter of the inlet pipe 16d of the pressure sensor 16.Also, the inner circumferential cylindrical portion 392c is configured to have an inner diameter slightly smaller than the outer diameter of the O ring 394.The inner circumferential cylindrical portion 392c is configured to have an outer diameter slightly larger than the inner diameter of the nipple 382.A radial spacing between the inner circumferential cylindrical portion 392c and the outer circumferential cylindrical portion 392a is configured to be sufficiently larger than the thickness of the nipple 382 of the fluid bladder 22 so as to allow insertion of the nipple 382 of the fluid bladder 22 into the spacing.", "With this configuration, in a state in which the blood pressure meter 1 is assembled and the sub-assembly 12′ (the main body assembly 12) is attached to the lower housing 13, the outlet pipe 17d of the piezoelectric pump 17 extends in the −Z direction beyond the inner circumferential edge 391e of the engaging plate portion 391f of the inner circumferential cylindrical portion 391c.", "At the same time, the O ring 393 is press fitted into the inner circumferential cylindrical portion 391c so as to realize hermetic sealing between the outlet pipe 17d and the inner circumferential cylindrical portion 391c.", "Likewise, the inlet pipe 16d of the pressure sensor 16 extends in the −Z direction beyond the inner circumferential edge 392e of the engaging plate portion 392f of the inner circumferential cylindrical portion 392c.", "At the same time, the O ring 394 is press fitted into the inner circumferential cylindrical portion 392c so as to realize hermetic sealing between the inlet pipe 16d and the inner circumferential cylindrical portion 392c Furthermore, in a state in which the fluid bladder 22 is attached to the lower housing 13, the nipple 381 of the fluid bladder 22 is press fitted to an outer circumference of the inner circumferential cylindrical portion 391c so as to realize hermetic sealing between the inner circumferential cylindrical portion 391c and the nipple 381.Likewise, the nipple 382 of the fluid bladder 22 is press fitted to an outer circumference of the inner circumferential cylindrical portion 392c so as to realize hermetic sealing between the inner circumferential cylindrical portion 392c and the nipple 382.With this configuration, in the assembled blood pressure meter 1, the outlet pipe 17d of the piezoelectric pump 17 and the nipple 381 of the fluid bladder 22 are hermetically attached to the inner circumferential cylindrical portion 391c of the bottom wall 13b of the lower housing 13, as a result of which, the first fluid path 41 extending straight in the Z direction is formed between the piezoelectric pump 17 and the fluid bladder 22.Likewise, the inlet pipe 16d of the pressure sensor 16 and the nipple 382 of the fluid bladder 22 are hermetically attached to the inner circumferential cylindrical portion 392c, as a result of which, the second fluid path 42 extending straight in the Z direction is formed between the pressure sensor 16 and the fluid bladder 22.Here, if a configuration is applied in which the inlet pipe 16d of the pressure sensor 16 and the nipple 382 of the fluid bladder 22 can be directly fitted and attached, stress may be applied to the pressure sensor 16 from the nipple 382 via the inlet pipe 16d and the sensor package 16p during assembly, which may compromise the characteristics of the pressure sensor 16.However, with the blood pressure meter 1, the inlet pipe 16d of the pressure sensor 16 and the nipple 382 that is in communication with the fluid bladder 22 are hermetically attached to the inner circumferential cylindrical portion 392c of the bottom wall 13b.", "Accordingly, it is possible to independently perform an operation to attach the inlet pipe 16d of the pressure sensor 16 to the inner circumferential cylindrical portion 392c of the bottom wall 13b and an operation to attach the nipple 382 that is in communication with the fluid bladder 22 to the inner circumferential cylindrical portion 392c of the bottom wall 13b.", "Thus, there is no possibility that the characteristics of the pressure sensor 16 will be compromised due to the application of stress from the nipple 382 during assembly.", "As a result, the reliability of assembly is enhanced.", "Also, as described above, the through holes 62w and 62x that are formed in the lower substrate 62 and serve as escaping portions are configured to have an inner diameter slightly larger than the outer diameter of the outer circumferential cylindrical portions 391a and 392a, which will be described later.", "Accordingly, the lower substrate 62 does not interfere with the first fluid path 41 and the second fluid path 42.Also, in this example, the lower substrate 62 on which the blood pressure measurement elements 170, 18, 180, .", ".", ".", "are mounted in addition to the piezoelectric pump 17 is disposed in spaces SP1 and SP2 (see FIG.", "12) that are located between the upper substrate 61 and the fluid bladder 22 in the Z direction and around the first fluid path 41 and the second fluid path 42 in the XY direction.", "Accordingly, the spaces SP1 and SP2 can be effectively used by the lower substrate 62.As a result, it is possible to promote miniaturization of the product, in particular, miniaturization in the planar direction (the XY direction).", "To be specific, if a configuration is applied in which the blood pressure measurement elements 17, 170, 18, 180, .", ".", ".", "that need to be mounted on the lower substrate 62 are mounted on the upper substrate 61 in the absence of the lower substrate 62, there is no option but to increase the dimension in the XY direction of the upper substrate 61 accordingly (by an amount corresponding to the increased region where the blood pressure measurement elements are disposed).", "However, with the blood pressure meter 1, the spaces SP1 and SP2 where a component is not disposed in a conventional blood pressure meter can be effectively used by the lower substrate 62.As a result, the dimension in the XY direction of the upper substrate 61 can be reduced, and miniaturization in the XY direction can be promoted.", "Also, as can be clearly seen from FIG.", "15, in this example, the battery 53 continuously occupies a range ΔZ in which at least the upper substrate 61 and the lower substrate 62 are disposed in the Z direction.", "As a result, the capacity of the battery 53 can be increased.", "FIGS.", "16(A) and 16(B) show, in a laid-out state, the upper substrate 61 and the lower substrate 62 that are connected to each other by the FPC cable 63 before the sub-assembly 12′ is assembled.", "FIG.", "16(A) shows the upper surface 61a of the upper substrate 61 and the lower surface 62b of the lower substrate 62.FIG.", "16(B) shows the lower surface 61b of the upper substrate 61 and the upper surface 62a of the lower substrate 62, which corresponds to the back side of FIG.", "16(A).", "In the sub-assembly 12′ (the main body assembly 12), the upper substrate 61 is disposed above the lower substrate 62 so as to oppose the lower substrate 62 as a result of the FPC cable 63 being bent as indicated by the arrow F in FIG.", "16(B).", "In FIGS.", "16(A) and 16(B), the USB substrate 55P connected to the upper substrate 61 by the FPC cable 55F and the switch substrate 52P connected to the lower substrate 62 by the FPC cable 52F are also shown.", "As can be clearly seen from FIG.", "16(A), in the upper substrate 61, a region 61u in which the pressure sensor 16 is mounted is provided adjacent to a region 61v in which the CPU 100 (including the oscillation circuit 160) is mounted.", "Accordingly, the interconnect between the pressure sensor 16 and the CPU 100 is relatively short, which makes it unlikely that noise will be included in the output of the pressure sensor 16.As a result, the accuracy of blood pressure measurement is enhanced.", "The upper substrate 61 includes a substantially rectangular island shaped portion 61s that protrudes in an upper right diagonal direction in FIG.", "16(A).", "The island shaped portion 61s includes a contact electrode 53s that is connected to the battery 53.Also, as can be clearly seen from FIG.", "16(B), a region 62u of the substantially rectangular lower substrate 62 in which the pump driving circuit 170 is mounted is provided to be spaced apart from the region 61u of the upper substrate 61 in which the pressure sensor 16 is mounted in the planar direction (the XY direction) (rather, the region 61u opposes the piezoelectric pump 17 shown in FIG.", "12).", "Furthermore, in order to transmit a drive current from the pump driving circuit 170 to the piezoelectric pump 17, a lead wire 170e (see FIG.", "12) that electrically connects the lower substrate 62 and the piezoelectric pump 17 is connected to an end portion of the piezoelectric pump 17 that is on the opposite side of the pressure sensor 16 in the planar direction (the XY direction).", "Accordingly, the distance from the pressure sensor 16 to the pump driving circuit 170 and the lead wire 170e is increased, and thus heat generated in the pump driving circuit 170 and the lead wire 170e due to the electric current that drives the piezoelectric pump 17 is unlikely to be transferred to the pressure sensor 16.As a result, the output of the pressure sensor 16 is unlikely to be affected by the generated heat, and the accuracy of blood pressure measurement is further enhanced.", "Also, as can be seen from FIGS.", "11 and 10A, in the assembled main body assembly 12, at least the region 61u of the upper substrate 61 in which the pressure sensor 16 is mounted and the region 61v of the upper substrate 61 in which the CPU 100 is mounted shown in FIG.", "16(A) are shielded, in the thickness direction (Z direction), by the display device 50 including the metal plate 50c that is disposed extending outward of the upper substrate 61 and the lower substrate 62 that is disposed extending inward of the upper substrate 61.Accordingly, this makes it more unlikely that noise will be included in the output of the pressure sensor 16.As a result, the accuracy of blood pressure measurement is further enhanced.", "The embodiment described above is configured such that, as schematically shown in FIG.", "17, the pressure sensor 16 is incorporated in the substantially rectangular parallelepipedal shape sensor package 16p and mounted on the upper surface 61a of the upper substrate 61.However, the configuration is not limited thereto.", "For example, as shown in FIG.", "18, a pressure sensor 16′ may be incorporated in a substantially rectangular parallelepipedal sensor package 16p′ and mounted on the lower surface 61b of the upper substrate 61.In this case, lead terminals 16e′ and 16f′ of the pressure sensor 16′ are connected to an interconnect (not shown) provided on the lower surface 61b of the upper substrate 61.An inlet pipe 16d′ extends straight in the −Z direction from a surface 16a′of the sensor package 16p′ that is distant from the upper substrate 61 toward the fluid bladder 22 through the through hole 62x that is formed in the lower substrate 62 and serves as an escaping portion.", "In the example shown in FIG.", "18 as well, a space SP2 around the second fluid path 42 (and a space SP1 around the first fluid path 41) where a component is not disposed in a conventional blood pressure meter can be effectively used by the lower substrate 62.As a result, the dimension in the XY direction of the upper substrate 61 can be reduced, and miniaturization in the XY direction can be promoted.", "Also, the embodiment described above is configured such that, as shown in, for example, FIGS.", "12 and 13, the through holes 62w and 62x that are formed in the plane surface of the lower substrate 62, or in other words, that are formed internally in the planar direction (the XY direction) are used as the escaping portions formed in the lower substrate 62.However, the configuration is not limited thereto.", "The escaping portions formed in the lower substrate 62 may be cut-out portions formed in the peripheral edge of the lower substrate 62.Also, the embodiment described above is configured such that the main body 10 of the blood pressure meter 1 is disposed in the base end portion a in the lengthwise direction of the belt 20, but the configuration is not limited thereto.", "The main body 10 may be disposed in, for example, a center portion in the lengthwise direction of the belt 20.The above-described embodiment is merely an example, and various modifications are possible without departing from the scope of the present invention.", "Also, multiple embodiments described above can be achieved independently or in combination with each other.", "Also, various characteristics of different embodiments can be achieved independently or in combination with each other.", "REFERENCE NUMERALS LIST 1 Blood pressure meter 10 Main body 16 Pressure sensor 17 Piezoelectric pump 18 Valve 20 Belt 22 Fluid bladder 23 Reinforcing layer 24 Outer circumferential layer 25 Engaged portion 29 Sheet 30 Buckle 30a First plate frame member 30b Second plate frame member 31 Projection portion 32 Engaging portion 33 Magnet 41 First fluid path 42 Second fluid path 50 Display device 51 Memory 52 Operation unit 52A Power supply switch 52B Blood pressure measurement switch 53 Battery 61 Upper substrate 62 Lower substrate 61x, 62w, 62x Through hole 160 Oscillation circuit 170 Pump driving circuit 180 Valve driving circuit 100 CPU" ] ]
Patent_15876002
[ [ "UPRIGHT AND INVERTED MICROSCOPE", "A dual-configuration microscope is provided that may be converted into an upright or inverted microscope.", "The microscope includes a body having a plurality of planar surfaces, each planar surface configured to support the body on a working surface as the body is tilted between the upright and inverted configurations.", "The microscope further includes an objective, a condenser, a stage positioned between the objective and the condenser, and a portable display device to display a specimem." ], [ "1.A microscope comprising: a body configured to be converted from an upright to inverted configuration; wherein the body comprises a plurality of planar surfaces, each planar surface configured to support the body on a working surface as the body is tilted between the upright and inverted configurations; an objective disposed on the body for viewing a specimen; a condenser disposed on the body for illuminating the specimen; a stage disposed between the objective and the condenser for supporting the specimen; and an internal camera disposed within the body, the internal camera configured to capture an image of the specimen; wherein when the body is in the upright configuration, the objective is disposed vertically above the condenser; and wherein when the body is in the inverted configuration, the condenser is disposed vertically above the objective.", "2.The microscope of claim 1, wherein the stage comprises a first specimen supporting surface and a second specimen supporting surface, wherein the second specimen supporting surface is positioned opposite the first specimen supporting surface.", "3.The microscope of claim 1, wherein the plurality of planar surfaces comprise a first, second, and third planar surface.", "4.The microscope of claim 1, wherein the plurality of planar surfaces comprise a first, second, third, and fourth planar surface.", "5.The microscope of claim 1, wherein the plurality of planar surfaces comprise a first, second, third, fourth, and fifth planar surface.", "6.The microscope of claim 1, further comprising a plurality of focus knob receptacles disposed on the body, wherein each focus knob receptacle is configured to receive a removable focus knob.", "7.The microscope of claim 6, wherein the removable focus knob is further configured to receive user input for controlling an operation of the microscope.", "8.The microscope of claim 7, wherein the operation comprises a focusing operation using the objective.", "9.The microscope of claim 1, further comprising a portable display device configured to display the image of the specimen captured by the internal camera.", "10.The microscope of claim 9, further comprising a first supporting slot disposed on a first planar surface of the plurality of planar surfaces, the first supporting slot configured to support the portable display device on the body.", "11.The microscope of claim 10, further comprising a second supporting slot disposed on a second planar surface of the plurality of planar surfaces, the second supporting slot disposed opposite the first supporting slot and configured to support the portable display device on the body.", "12.The microscope of claim 11, further comprising a first rotating stand disposed on the first planar surface of the plurality of planar surfaces, the first rotating stand configured to support the portable display device on the body.", "13.The microscope of claim 12, further comprising a second rotating stand disposed on the second planar surface of the plurality of planar surfaces, the second rotating stand disposed opposite the first rotating stand and configured to support the portable display device on the body.", "14.The microscope of claim 1, further comprising a communications module configured to transmit data representing the image of the specimen captured by the internal camera to the portable display device.", "15.A method for converting a microscope from an upright to inverted configuration, the method comprising: tilting a body from an upright configuration to a first intermediate position on a working surface, the body comprising a plurality of planar surfaces, each planar surface configured to support the body on a working surface as the body is tilted between the upright configuration and an inverted configuration, the body further comprising: an objective disposed on the body for viewing a specimen; a condenser disposed on the body for illuminating the specimen; and a stage disposed between the objective and the condenser for supporting the specimen; wherein when the body is in the upright configuration, the objective is disposed vertically above the condenser; and wherein when the body is in the inverted configuration, the condenser is disposed vertically above the objective; tilting the body from the first intermediate position to a second intermediate position on the working surface; tilting the body from the second intermediate position to a third intermediate position on the working surface; and tilting the body from the third intermediate position to the inverted configuration.", "16.The method of claim 15, wherein the body further comprises a portable display device disposed on the body and configured to display the specimen.", "17.The method of claim 15, wherein the plurality of planar surfaces comprise a first, second, third, fourth, and fifth planar surface.", "18.The method of claim 15, further comprising mounting a portable display device onto a slot, wherein the slot is disposed on one planar surface of the plurality of planar surfaces.", "19.The method of claim 15, further comprising inserting a removable focus knob into one of a plurality of focus knob receptacles, the plurality of focus knob receptacles disposed on the body and each configured to receive the removable focus knob.", "20.The method of claim 15, further comprising rotating a first stand disposed on the body to a deployed position, the first stand configured to rotate between the deployed position and a stowed position; wherein when in the deployed position, the first stand supports a portable display device on the body; and wherein when in the stowed position, the an outer surface of the first stand is flush with the body." ], [ "<SOH> BACKGROUND <EOH>Conventionally, there are two types of microscope configurations, upright and inverted.", "Generally, upright and inverted microscopes differ in the manner by which a specimen, an objective, and a light source are arranged with respect to each other.", "For example, in an upright microscope, the objective is arranged so that it is disposed vertically above the specimen and the light source is disposed vertically below the specimen.", "In an inverted microscope, the objective is arranged so that it is disposed vertically below the specimen and the objective is disposed vertically above the specimen.", "Accordingly, an optic train, that is the arrangement of lenses generally housed within a housing and used to reflect light from the light source and specimen to a user, is arranged either above or below the specimen along with the objective.", "In both upright and inverted microscopes, focusing of the specimen is accomplished by way of a corresponding positioning of the specimen relative to the objective, specifically in such a way that a region of the specimen to be observed is arranged in a focal plane of the objective.", "In one example, the position of the specimen relative to the objective may be adjusted by moving the objective along an optical axis relative to the specimen.", "In this case, the specimen may be mounted on a conventional specimen slide or dish that is secured to a corresponding specimen holder on a microscope stage.", "In this example, the microscope stage may be fixed such that it does not move in the direction of the optical axis of the objective.", "In another example, the position of the specimen relative to the objective may be adjusted by mechanically moving the stage along the optical axis in order to focus on the desired specimen region.", "In this example, the position of the objective would be fixed along the direction of its optical axis.", "In both examples, the stage may also be configured so that it may horizontally move relative to a microscope body along a single plane in at least two directions, such as in an X and a Y direction.", "In both examples, focusing of the specimen region is usually performed by the user by operating an interface element arranged on the microscope body, as a result of which either the objective or the microscope stage is positioned along the optical axis.", "The interface element may comprise a rotary knob.", "Rotation of the rotary knob by the user causes linear motion of the objective or the stage along the optical axis.", "Typically, the rotary knob is arranged proximal to a working surface on which the microscope rests." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>The accompanying drawings, which are included to provide further understanding of the subject technology and are incorporated in and constitute a part of this specification, illustrate aspects of the subject technology and together with the description serve to explain the principles of the subject technology.", "FIG.", "1 illustrates an embodiment of a rotating microscope positioned in an upright configuration.", "FIG.", "2 illustrates an embodiment of a rotating microscope positioned in an example of an intermediate configuration.", "FIG.", "3A illustrates a cross section view of an embodiment of a rotational coupling of a rotating microscope.", "FIG.", "3B illustrates a cross section view of an embodiment of a stage.", "FIG.", "4A illustrates an embodiment of a height compensator in a first position.", "FIG.", "4B illustrates an embodiment of the height compensator of FIG.", "4A in a second position.", "FIG.", "5 illustrates an embodiment of a rotating microscope positioned in an inverted configuration.", "FIG.", "6 illustrates an embodiment of a flipping microscope in an upright configuration.", "FIG.", "7 illustrates an embodiment of a flipping microscope in an inverted configuration.", "FIG.", "8 illustrates an embodiment of a reconfigurable microscope in an upright configuration.", "FIG.", "9 illustrates an embodiment of the reconfigurable microscope of FIG.", "8 in an inverted configuration.", "FIG.", "10A illustrates an embodiment of a mounting feature.", "FIG.", "10B illustrates an embodiment of an interchangeable component.", "FIGS.", "11A-11C illustrate an embodiment of a modular microscope in an upright configuration.", "FIGS.", "12A-12C illustrate an embodiment of the modular microscope of FIGS.", "11A-11C in an inverted configuration.", "FIGS.", "13A-13B illustrate an embodiment of a base of a modular microscope.", "FIG.", "14A-14B illustrate a condenser module of a modular microscope.", "FIG.", "14C-14D illustrate an objective module of a modular microscope.", "FIG.", "15 illustrates an embodiment of a swing arm microscope.", "FIG.", "16A illustrates an embodiment of an upper swing arm.", "FIG.", "16B illustrates an embodiment of a lower swing arm.", "FIGS.", "17A-17B illustrate an embodiment of a laterally rotating microscope.", "FIG.", "18 illustrates a high-level schematic block diagram of an embodiment of an electronic system for use with a reconfigurable microscope as described herein.", "FIG.", "19 illustrates and example of a user interface provided on a mobile computing device configured to cooperate with a dual-configuration microscope.", "FIGS.", "20A-20B illustrate an embodiment of a stage for use with a dual-configuration microscope.", "FIGS.", "21A-21B illustrate an embodiment of a rotating microscope in an upright configuration.", "FIG.", "21C illustrates an embodiment of the rotating microscope of FIGS.", "21A-21B in an inverted configuration.", "FIG.", "21D illustrates an embodiment of a Dove prism housing.", "FIG.", "22 illustrates an embodiment of a tilting microscope.", "FIG.", "23A illustrates an embodiment of a tilting microscope positioned in an upright configuration.", "FIG.", "23B illustrates an embodiment of a tilting microscope positioned in an upright configuration.", "FIG.", "24A illustrates an embodiment of a tilting microscope positioned in an inverted configuration.", "FIG.", "24B illustrates an embodiment of a tilting microscope positioned in an inverted configuration.", "FIG.", "25A illustrates an embodiment of a tilting microscope positioned in an upright configuration.", "FIG.", "25B illustrates an embodiment of a tilting microscope positioned in an intermediate configuration.", "FIG.", "25C illustrates an embodiment of a tilting microscope positioned in an intermediate configuration.", "FIG.", "25D illustrates an embodiment of a tilting microscope positioned in an intermediate configuration.", "FIG.", "25E illustrates an embodiment of a tilting microscope positioned in an inverted configuration.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation-in-part of non-provisional application Ser.", "No.", "15/682,423, filed Aug. 21, 2017, which is a continuation of non-provisional application Ser.", "No.", "15/238,593, filed Aug. 16, 2016, now U.S. Pat.", "No.", "9,746,657, which is a continuation of non-provisional application Ser.", "No.", "15/003,694, filed Jan. 21, 2016, now U.S. Pat.", "No.", "9,435,990, which is a continuation of non-provisional application Ser.", "No.", "14/832,694, filed Aug. 21, 2015, now U.S. Pat.", "No.", "9,348,129, which is a continuation of non-provisional application Ser.", "No.", "14/494,519, filed Sep. 23, 2014, now U.S. Pat.", "No.", "9,140,885, which is a continuation of International Patent Application No.", "PCT/US2014/044707, filed Jun.", "27, 2014, which claims priority to U.S.", "Provisional Patent Application Ser.", "No.", "61/841,229, filed Jun.", "28, 2013, the disclosures of which are incorporated herein by reference in their entirety.", "TECHNICAL FIELD The systems and methods disclosed herein generally relate to microscopes, and more particularly to a microscope configured to be used in both an upright configuration and an inverted configuration.", "BACKGROUND Conventionally, there are two types of microscope configurations, upright and inverted.", "Generally, upright and inverted microscopes differ in the manner by which a specimen, an objective, and a light source are arranged with respect to each other.", "For example, in an upright microscope, the objective is arranged so that it is disposed vertically above the specimen and the light source is disposed vertically below the specimen.", "In an inverted microscope, the objective is arranged so that it is disposed vertically below the specimen and the objective is disposed vertically above the specimen.", "Accordingly, an optic train, that is the arrangement of lenses generally housed within a housing and used to reflect light from the light source and specimen to a user, is arranged either above or below the specimen along with the objective.", "In both upright and inverted microscopes, focusing of the specimen is accomplished by way of a corresponding positioning of the specimen relative to the objective, specifically in such a way that a region of the specimen to be observed is arranged in a focal plane of the objective.", "In one example, the position of the specimen relative to the objective may be adjusted by moving the objective along an optical axis relative to the specimen.", "In this case, the specimen may be mounted on a conventional specimen slide or dish that is secured to a corresponding specimen holder on a microscope stage.", "In this example, the microscope stage may be fixed such that it does not move in the direction of the optical axis of the objective.", "In another example, the position of the specimen relative to the objective may be adjusted by mechanically moving the stage along the optical axis in order to focus on the desired specimen region.", "In this example, the position of the objective would be fixed along the direction of its optical axis.", "In both examples, the stage may also be configured so that it may horizontally move relative to a microscope body along a single plane in at least two directions, such as in an X and a Y direction.", "In both examples, focusing of the specimen region is usually performed by the user by operating an interface element arranged on the microscope body, as a result of which either the objective or the microscope stage is positioned along the optical axis.", "The interface element may comprise a rotary knob.", "Rotation of the rotary knob by the user causes linear motion of the objective or the stage along the optical axis.", "Typically, the rotary knob is arranged proximal to a working surface on which the microscope rests.", "BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are included to provide further understanding of the subject technology and are incorporated in and constitute a part of this specification, illustrate aspects of the subject technology and together with the description serve to explain the principles of the subject technology.", "FIG.", "1 illustrates an embodiment of a rotating microscope positioned in an upright configuration.", "FIG.", "2 illustrates an embodiment of a rotating microscope positioned in an example of an intermediate configuration.", "FIG.", "3A illustrates a cross section view of an embodiment of a rotational coupling of a rotating microscope.", "FIG.", "3B illustrates a cross section view of an embodiment of a stage.", "FIG.", "4A illustrates an embodiment of a height compensator in a first position.", "FIG.", "4B illustrates an embodiment of the height compensator of FIG.", "4A in a second position.", "FIG.", "5 illustrates an embodiment of a rotating microscope positioned in an inverted configuration.", "FIG.", "6 illustrates an embodiment of a flipping microscope in an upright configuration.", "FIG.", "7 illustrates an embodiment of a flipping microscope in an inverted configuration.", "FIG.", "8 illustrates an embodiment of a reconfigurable microscope in an upright configuration.", "FIG.", "9 illustrates an embodiment of the reconfigurable microscope of FIG.", "8 in an inverted configuration.", "FIG.", "10A illustrates an embodiment of a mounting feature.", "FIG.", "10B illustrates an embodiment of an interchangeable component.", "FIGS.", "11A-11C illustrate an embodiment of a modular microscope in an upright configuration.", "FIGS.", "12A-12C illustrate an embodiment of the modular microscope of FIGS.", "11A-11C in an inverted configuration.", "FIGS.", "13A-13B illustrate an embodiment of a base of a modular microscope.", "FIG.", "14A-14B illustrate a condenser module of a modular microscope.", "FIG.", "14C-14D illustrate an objective module of a modular microscope.", "FIG.", "15 illustrates an embodiment of a swing arm microscope.", "FIG.", "16A illustrates an embodiment of an upper swing arm.", "FIG.", "16B illustrates an embodiment of a lower swing arm.", "FIGS.", "17A-17B illustrate an embodiment of a laterally rotating microscope.", "FIG.", "18 illustrates a high-level schematic block diagram of an embodiment of an electronic system for use with a reconfigurable microscope as described herein.", "FIG.", "19 illustrates and example of a user interface provided on a mobile computing device configured to cooperate with a dual-configuration microscope.", "FIGS.", "20A-20B illustrate an embodiment of a stage for use with a dual-configuration microscope.", "FIGS.", "21A-21B illustrate an embodiment of a rotating microscope in an upright configuration.", "FIG.", "21C illustrates an embodiment of the rotating microscope of FIGS.", "21A-21B in an inverted configuration.", "FIG.", "21D illustrates an embodiment of a Dove prism housing.", "FIG.", "22 illustrates an embodiment of a tilting microscope.", "FIG.", "23A illustrates an embodiment of a tilting microscope positioned in an upright configuration.", "FIG.", "23B illustrates an embodiment of a tilting microscope positioned in an upright configuration.", "FIG.", "24A illustrates an embodiment of a tilting microscope positioned in an inverted configuration.", "FIG.", "24B illustrates an embodiment of a tilting microscope positioned in an inverted configuration.", "FIG.", "25A illustrates an embodiment of a tilting microscope positioned in an upright configuration.", "FIG.", "25B illustrates an embodiment of a tilting microscope positioned in an intermediate configuration.", "FIG.", "25C illustrates an embodiment of a tilting microscope positioned in an intermediate configuration.", "FIG.", "25D illustrates an embodiment of a tilting microscope positioned in an intermediate configuration.", "FIG.", "25E illustrates an embodiment of a tilting microscope positioned in an inverted configuration.", "DETAILED DESCRIPTION As discussed above, there conventionally are two types of microscope configurations, upright and inverted.", "These two types of microscopes are separate from one another and if a user desires to utilize an upright and inverted microscope, the user must have two separate microscopes at their disposal.", "Having two separate microscopes thereby increases the equipment and maintenance costs to the user and further, requires additional physical space to store and use the separate microscopes.", "The dual-configuration microscopes of the subject technology address the foregoing problems, among others, by allowing the user to convert a single microscope from an upright configuration into an inverted configuration, and vice versa.", "Rotating Embodiment FIGS.", "1-5 illustrate an example of a rotating microscope 100.Referring to FIG.", "1, the microscope 100 is depicted in an upright configuration.", "The microscope 100 comprises a unitary base 102 and a body 104.The base 102 comprises a lower portion 102A and an upper portion 102B.", "The lower portion 102A extends in a substantially horizontal plane and the upper portion 102B extends in a substantially vertical plane.", "The upper portion 102B may be disposed at about a 90 degree angle from the lower portion 102A and may further, be manufactured as a single component.", "Alternatively, the lower portion 102A and upper portion 102B may be formed of two or more separate components and attached, fastened, or otherwise coupled together to form the base 102.The lower portion 102A is configured to support the microscope 100 on a working surface 10.The base 102 may be formed of a metal alloy, composite, polymer, or other sufficiently rigid material that is capable of supporting the weight and proper use of the microscope 100, as known by those having ordinary skill in the art.", "The body 104 comprises a first portion 104A, a second portion 104B, and an intermediate portion 104C extending between the first and second portions, 104A and 104B respectively.", "The intermediate portion 104C may be rotatably coupled to the upper portion 102B of the base 102 at a rotational coupling (shown in FIG.", "3A).", "The rotational coupling 130 allows the body 104 to rotate with respect to the base 102 along a rotating axis 120 that extends in a longitudinal direction with respect to the microscope 100, as shown in FIG.", "2.To facilitate rotation of the body 104 with respect to the base 102, in some embodiments an outer surface 152A (see, for example, FIG.", "1) of the first portion 104A and an outer surface 152B (see, for example, FIGS.", "2 and 5) of the second portion 104B may each have a convex profile that corresponds to a concave profile of an outer surface 153 of the lower portion 102A.", "The convex and concave outer surfaces thereby prevent interference between the body 104 and the base 102 during rotation.", "FIG.", "3A illustrates a cross section view of one embodiment of the rotational coupling 130 of the microscope 100.The rotational coupling 130 may comprise a shaft 132 extending longitudinally from the upper portion 102B of the base 102 and a corresponding bore 134 disposed within the intermediate portion 104C of the body 104.The shaft 132 and bore 134 are arranged to permit the body 104 to rotate about the rotating axis 120, as shown in FIG.", "2.The rotational coupling 130 is provided as one example of a suitable coupling between the base 102 and the body 104.In other embodiments, variations of rotational couplings from the illustrated coupling in FIG.", "3A can be used to facilitate rotation of the body 104 around the rotating axis 120.For example, a ball bearing coupling, a rigid coupling between a first rotating shaft of the body 104 and a second rotating shaft of the base 102, a wheel and axle, or other suitable couplings allowing rotation may be used to permit rotation of the body 104 relative to the base 102.In some embodiments, the rotational coupling may be coated or treated to reduce friction.", "In some embodiments, the rotational coupling may be configured to stop or lock when the body 104 is in the inverted and upright positions.", "Referring to FIG.", "1, the body 104 is configured to support, directly or indirectly, at least one objective 113, a stage 114, a condenser 116, and/or a light source (not shown).", "The body 104 may be formed of a metal alloy, composite, polymer, or other sufficiently rigid material capable of supporting the objective 113, stage 114, condenser 116, and/or light source.", "The body 104 may be manufactured as a single component or may comprise a multitude of components that are attached, fastened, or otherwise assembled together, as known by those having ordinary skill in the art.", "The objective 113 may be mounted to a nosepiece 112 and is disposed proximal to the first portion 104A of the body 104.The objective 113 comprises a cylinder containing one or more lenses configured to collect light from a specimen being observed.", "The objective 113 further defines an optical axis 124 that, when in a working position, runs perpendicular to the stage 114.The stage 114 supports the specimen being observed on a specimen supporting surface 119A, as discussed further below.", "The condenser 116 and light source may be disposed proximal to the second portion 104B of the body 104.Particularly, the condenser 116 may be mounted on the second portion 104B and the light source may be mounted within the body 104.The condenser 116 includes a lens that serves to concentrate light from the light source into a cone of light that illuminates the specimen.", "The stage 114 is a platform configured to support the specimen being observed.", "The stage 114 may include an opening aligned with the condenser 116, to allow light to pass through the stage 114 and illuminate the specimen.", "In one example, the stage 114 may be configured to be removably attached to the intermediate portion 104C of the body 104.For example, the stage 114 may include a substantially horizontal rail that is configured to slide within a substantially horizontal channel disposed within the intermediate portion 104C of the body 104.The stage 114 may thus, be attached to the body 104 by sliding the stage 114 horizontally toward the body 104.To remove the stage 114, the stage 114 may be slid horizontally away from the body 104, thereby disengaging the channel and rail assembly.", "In this example, the channel of the body 104 is configured to receive the rail of the stage 114 when the microscope 100 is in either the upright or inverted configuration.", "Accordingly, the channel of the body 104 and the rail of the stage 114 may have horizontally symmetrical profiles, such as a round, oval, rectangular, square or any combination thereof.", "In another example, the rail of the stage 114 may be configured to be inserted into a first or second substantially horizontal channel disposed within the intermediate portion 104C of the body 104.In this example, the rail of the stage 114 may be inserted into the first channel of the body 104 when the microscope 100 is in the upright configuration and into the second channel of the body 104 when the microscope 100 is in the inverted configuration.", "In some embodiments, the first and second channels of the body 104 and the rail of the stage 114 may not have horizontally symmetrical profiles in order to aid the user in knowing into which of the first or second channels to insert the rail of the stage 114.In some embodiments, the first and second channels of the body 104 can be arranged to maintain a distance between a specimen supporting surface 119A of the stage 114 and an outer surface of a lens of the objective 113, regardless of whether the microscope 100 is in the upright or inverted configuration.", "In particular, when the microscope 100 is in the upright configuration, the stage 114 can be inserted into the first channel.", "When in the first channel, the specimen supporting surface 119A is at a first distance away from the outer surface of the lens of the objective 113.When the microscope 100 is in the inverted configuration, the stage 114 can be inserted into the second channel.", "When in the second channel, the specimen supporting surface 119A is at a second distance away from the outer surface of the lens of the objective 113.The first and second channels are arranged on the body 104 so that the first and second distances are the same.", "Alternatively, the stage 114 may be mounted to a height compensator 115 that is disposed proximal to the intermediate portion 104C of the body 104.As shown in FIG.", "1, the stage 114 may be disposed between the objective 113 and the condenser 116.Other embodiments of stage configurations are discussed in more detail below.", "FIGS.", "4A and 4B illustrate a detail view of the height compensator 115 and the stage 114 in the first and second positions, respectively.", "The height compensator 115 may comprise at least one rail 117A that is configured to engage a corresponding channel 117B disposed within the stage 114.The rail 117A and the channel 117B are configured to permit the stage 114 to slide between a first position (shown in FIG.", "4A) and a second position (shown in FIG.", "4B) along the optical axis 124.Although a rail and channel arrangement are shown in FIGS.", "4A and 4B, it is known by those having ordinary skill in the art that other mechanisms may be used to permit sliding of the stage between the first and second positions.", "When the stage is in the first position (shown in FIG.", "4A), the microscope 100 is in the upright configuration (as shown in FIG.", "1).", "When the stage is in the second position (shown in FIG.", "4B), the microscope is in the inverted configuration (as shown in FIG.", "5).", "In one embodiment, the stage 114 slides between the first and second positions based on gravity.", "Accordingly, the stage 114 may move between the first and second positions automatically when the body 104 is rotated from the upright configuration to the inverted configuration.", "Similarly, the stage 114 may move between the second and first positions automatically when the body 104 is rotated from the inverted configuration to the upright configuration.", "Movement of the stage between the first and second position can maintain a focal distance between the objective and the specimen-supporting (e.g., upward-facing) surface of the stage when the body 104 is rotated between the inverted configuration and the upright configuration.", "Similarly, movement of the stage between the first and second position can maintain a working distance between the condenser and the specimen-supporting (e.g., upward-facing) surface of the stage when the body 104 is rotated between the inverted configuration and the upright configuration.", "In some aspects, the stage 114 comprises, on an outer surface, a first specimen supporting surface 119A and at an opposite surface, a second specimen supporting surface 119B.", "When the microscope 100 is in the upright configuration and thus, the stage 114 is in the first position, the first specimen supporting surface 119A is facing upward and therefore configured to support the specimen.", "When the microscope 100 is in the inverted configuration and thus, the stage 114 is in the second position, the second specimen supporting surface 119B is facing upward and therefore configured to support the specimen.", "In some aspects, each of the first and second specimen supporting surfaces, 119A and 119B respectively, may comprise a specimen securing element 143 that is configured to secure a specimen.", "The specimen securing element 143 may secure the specimen through mechanical, magnetic, or electromechanical means.", "For example, the specimen securing element 143 may comprise stage clips to mechanically secure the specimen to the stage.", "Alternatively, each of the first and second specimen supporting surfaces, 119A and 119B respectively, may comprise a recessed pocket 144 that is configured to accept an interchangeable insert 145.The interchangeable insert 145 may be selected based on the type of specimen to be observed, such as a specimen slide or specimen petri dish.", "In this example, the interchangeable insert 145 itself, supports the specimen.", "In some aspects, when the stage 114 is in the first position, the first specimen supporting surface 119A is positioned at a distance “D1” from an outer surface of a lens of the objective 113 and a distance “D3” from an outer surface of the condenser 116.Likewise, when the stage 114 is in the second position, the second specimen supporting surface 119B is positioned at a distance “D2” from the outer surface of the lens of the objective 113 and a distance “D4” from an outer surface of the condenser 116.To maintain the appropriate distance between the specimen supporting surface and the lens of the objective 113 and/or condenser 116, the height compensator 115 allows the stage 114 to move between the first and second positions, as discussed above.", "By doing so, the height compensator 115 allows D2 to be the same value as D1 when the microscope 100 is converted from the upright configuration to the inverted configuration.", "Likewise, the height compensator 115 allows D1 to be the same value as D2 when the microscope 100 is converted from the inverted configuration to the upright configuration.", "Similarly, the height compensator 115 allows D3 to be the same value as D4 when the microscope 100 is converted from the upright configuration to the inverted configuration.", "Likewise, the height compensator 115 allows D4 to be the same value as D3 when the microscope 100 is converted from the inverted configuration to the upright configuration.", "In other words, the height compensator 115 maintains the distance (D1 or D2) between the appropriate specimen supporting surface (119A or 119B) and the lens of the objective 113, and/or the distance (D3 or D4) between the appropriate specimen supporting surface (119A or 119B) and the lens of the condenser 116, regardless of whether the microscope 100 is in the upright configuration or the inverted configuration.", "Accordingly, the position of a focal plane of the objective 113, with respect to the appropriate specimen supporting surface (119A or 119B), remains unchanged.", "Likewise, the position of the condenser 116, with respect to the appropriate specimen supporting surface (119A or 119B)—the distance of which is generally referred to as the working distance—remains unchanged.", "FIG.", "3B illustrates a cross section view of the stage 114.In some aspects, the stage 114 comprises a removable and repositionable stage displacement handle 126.Rotation of the handle causes the displacement of the stage 114 in the X and Y directions, both of which are generally horizontal and parallel to the working surface 10 that supports the microscope 100.The handle 126 comprises a shaft 127 having a first gear 128A and a second gear 128B disposed at a distal portion of the shaft 127, and a first knob 129A and a second knob 129B disposed at a proximal portion of the shaft 127.Rotation of the first knob 129A causes rotation of the first gear 128A.", "Rotation of the first gear 128A causes displacement of the stage 114 in the X direction.", "Rotation of the second knob 129B causes rotation of the second gear 128B.", "Rotation of the second gear 128B causes displacement of the stage 114 in the Y direction.", "The stage 114 further comprises at least one receptacle 140A configured to receive the distal portion of the shaft 127 and the first and second gears, 128A and 128B, respectively.", "In one aspect, the receptacle 140A is configured to receive the distal portion of the shaft 127 from either the first or second specimen supporting surfaces 119A, 119B.", "In other words, the distal portion of shaft 127 may be inserted into the receptacle 140A from either the first specimen supporting surface 119A side, or the second specimen supporting surface 119B side.", "In this way, when the microscope 100 is rotated from the upright configuration to the inverted configuration, the handle 126 may be removed from the receptacle 140A, such as from the second specimen supporting surface 119B side, and reinserted into the receptacle 140A from the first specimen supporting surface 119A side, thereby repositioning the handle 126 so that it remains proximal to the working surface 10 that supports the microscope 100.Similarly, when the microscope 100 is rotated from the inverted configuration to upright configuration, the handle 126 may be removed from the receptacle 140A, such as from the first specimen supporting surface 119A side, and reinserted into the receptacle 140A from the second specimen supporting surface 119B side, thereby repositioning the handle 126 so that it remains proximal to the working surface 10 that supports the microscope 100.In some aspects, the stage 114 may include a second receptacle 140B that is disposed laterally away from the first receptacle 140A.", "Upon conversion of the microscope 100 from the upright configuration to the inverted configuration, the handle 126 may, for example, be removed from the first receptacle 140A and inserted into the second receptacle 140B, thereby allowing the handle 126 to remain on the right side of the microscope 100.Accordingly, the first and second receptacles, 140A and 140B respectively, provide for the handle 126 to remain on a common side of the microscope 100, regardless of whether the microscope 100 is in the upright configuration or in the inverted configuration.", "Referring to FIG.", "3B, upon insertion of the handle 126 into the receptacle 140A, 140B the first gear 128A engages a corresponding third gear 128C disposed within the stage 114 and the second gear 128B engages a corresponding fourth gear 128D disposed within the stage 114.Although the use of gears are discussed herein with reference to displacing the stage 114 in the X and Y directions, it is understood that other mechanical methods may be used to control the displacement of the stage in the X and Y directions, such as the use of hexagonal shaped shafts, square shaped shafts, use of friction or snap fits, or any other mechanical methods as known by those having ordinary skill in the art.", "The handle 126 may further comprise a stop 141 that is configured to engage the first or second specimen supporting surfaces 119A, 119B.", "When engaged, the physical contact between the stop 141 and the first or second specimen supporting surfaces 119A, 119B prevents further insertion of the handle 126 into the receptacle 140A, 140B by mechanically preventing further movement of the handle 126 in a direction toward the stage 114.In some aspects, to prevent the handle 126 from inadvertently disengaging the receptacle 140A, 140B the handle 126 may comprise a magnetic element 142A that is configured to engage one or more corresponding magnetic elements 142B disposed within the stage 114.In particular, the magnetic elements 142B may be disposed proximate to the first and second specimen supporting surfaces, 119A and 119B respectively.", "The magnetic elements 142A, 142B maintain engagement of the shaft 127 within the receptacle 140A, 140B through a magnetic force acting between the magnetic elements 142A and 142B.", "Although the use of a magnetic force is discussed herein with reference to maintaining the shaft 127 within the receptacle 140A, 140B, it is understood that other methods may be used to maintain the shaft 127 within the receptacle 140A, 140B, such as the use of interference, friction or snap fits, or any other mechanical or electromechanical methods as known by those having ordinary skill in the art.", "Referring to FIG.", "1, the microscope 100 may further comprise an optical arm 106 disposed proximal to the first portion 104A of the body 104.The optical arm 106 may comprise an elongated housing forming an optical pathway therein, the optical pathway having an optical input at one end of the optical arm 106 and an optical output at an opposite end of the optical arm 106.The optical input of the of the optical arm 106 is configured to receive light that has entered the objective 113 and has been reflected toward the optical input of the optical arm 106 via one or more mirrors disposed within the first portion 104A of the body 104.Light entering the optical input of the optical arm 106 is then reflected to the optical output of the optical arm 106 via one or more mirrors disposed within the optical arm 106 and/or body 104.The optical arm 106, therefore, forms a portion of the optical path of the microscope 100.In another example, the optical arm 106 may be disposed proximal to the intermediate portion 104C of the body 104.In this example, the optical arm 106 may be disposed adjacent to the stage 114 and configured to direct light entering the objective to the optical output of the optical arm 106 via one or more mirrors disposed within the optical arm 106 and/or body 104.In yet another example, the optical arm 106 may be disposed proximal to the second portion 104B of the body 104.In this example, the optical arm 106 may be disposed adjacent to the working surface 10 and configured to direct light entering the objective to the optical output of the optical arm 106 via one or more mirrors disposed within the optical arm 106 and/or body 104.In some aspects, the optical arm 106 may be pivotably coupled to the first portion 104A of the body 104, thereby allowing the optical arm 106 to rotate about a pivoting axis 122.The pivoting axis 122 may extend in a lateral direction with respect to the microscope 100.The optical arm 106 may be configured to be positioned at varying angles, or at one or more predetermined angles.", "In one aspect, the optical arm 106 may be mechanically connected to a brake that prevents the body 104 from rotating.", "Accordingly, in order to rotate the body 104 and thereby convert the microscope 100 from an upright configuration to an inverted configuration, or from an inverted configuration to an upright configuration, the optical arm 106 must first be rotated towards the rotating axis 120 or toward the stage 114 in order to disengage the brake.", "In this way, the possibility of damaging the optical arm 106 or other related component through inadvertent collision with the lower portion 102A during rotation of the body 104, is reduced because the optical arm 106 is moved toward the rotating axis 120 and away from the lower base 102A, as shown in FIG.", "2.Referring to FIG.", "1, in some aspects the microscope 100 may further comprise a cradle 108 disposed at a distal portion of the optical arm 106 and proximal to the optical output of the optical arm 106.The cradle 108 is configured to receive and secure an electronic device 110 that is capable of acquiring images.", "Particularly, the cradle 108 aligns an optical input of the electronic device 110, such as a lens of a camera, with the optical output of the optical arm 106.The electronic device may comprise a mobile device, camera, tablet computer, laptop computer, PDA, portable computer, or other device that is capable of receiving light or other optical data, or acquiring an image.", "The electronic device 110 may further comprise a touch-sensitive screen display or other input mechanisms, such as buttons or keys, that are capable of receiving user input.", "In some aspects, a user may control operations of the microscope, such as focusing of a specimen, positioning of a specimen with respect to the objective 113, operation of the light source, control of the condenser 116, acquisition of an image, processing of an image, sending of an image to another device, altering light pathways and illumination settings, automated X-Y stage movement, controlling external hardware devices (e.g., camera), controlling other computer devices (e.g., onboard mini-computer, onboard controllers), communicating with other devices (such as through local area networks, wide area networks, broadband, Bluetooth, WiFi, or other wireless or wired communication methods), and other microscope related operations, by using the input mechanisms of the electronic device 110.The microscope 100 may further comprise a first and second focus knob 118A, 118B disposed laterally on the body 104.The first focus knob 118A may be disposed proximal to the first portion 104A of the body 104 and the second focus knob 118B may be disposed proximal to the second portion 104B of the body 104.The first and second focus knobs 118A, 118B may be configured to adjust a position of the objective 113 along the optical axis 124 to thereby position the specimen in a focal plane of the objective 113.Alternatively, the first and second focus knobs 118A, 118B may be configured to adjust a position of the height compensator 115 and stage 114, together, along the optical axis 124 to thereby position the specimen in a focal plane of the objective 113.A method for converting the microscope 100 from an upright configuration into an inverted configuration will now be discussed with reference to FIGS.", "1-5.To convert the microscope 100 from the upright configuration into the inverted configuration, the user may first rotate the optical arm 106 toward the stage 114.Rotation of the optical arm 106 towards the stage 114 may cause the brake to disengage, thereby allowing the body 104 to rotate about the rotating axis 120.Alternatively, the optical arm 106 may be configured to rotate towards the stage 114 upon rotation of the body 104.Rotating the optical arm 106 towards the stage 114 during rotation of the body 104 minimizes the likelihood that the optical arm 106 will be damaged during conversion of the microscope 100.The optical arm 106 may be configured to automatically rotate towards the stage 114 by, for example, mechanically coupling the optical arm 106 to the rotational coupling 130 via a cable and pulley system.", "In this example, upon rotation of the body 104, the cable is placed in tension thereby causing the optical arm 106 to rotate towards the stage 114.In another example, a stepper motor or solenoid may be coupled to the optical arm 106 and configured to actuate the optical arm 106 towards the stage 114 upon sensing rotation of the body 104.The user may then rotate the body 104 with respect to the base 102 in either a clockwise or counterclockwise direction along the rotating axis 120, as shown in FIG.", "2.The body 104 is rotated until the first portion 104A is adjacent to the lower portion 102A, as shown in FIG.", "5.As illustrated by FIG.", "2 and FIG.", "5, the body of the microscope occupies substantially the same three-dimensional area in the inverted configuration and in the upright configuration, and faces substantially the same direction in the inverted configuration and in the upright configuration.", "In the inverted configuration, the objective occupies substantially the same space as the condenser occupies in the upright configuration.", "Similarly, in the inverted configuration, the condenser occupies substantially the same space as the objective occupies in the upright configuration.", "This can provide a seamless user experience when converting the microscope between the upright and inverted configurations, as the microscope occupies substantially the same space above the workspace upon which the microscope is placed in both configurations, and also faces the same direction in both configurations.", "As the body 104 is rotated from the upright configuration into the inverted configuration, the stage 114 may automatically slide from the first position (as shown in FIG.", "4A), to the second position (as shown in FIG.", "4B), in a direction along the optical axis 124.As a result, referring to FIGS.", "4A and 4B, the distance between the specimen supporting surface (119A and 119B) and the outer surface of the lens of the objective 113 is maintained.", "In other words, the distance D2 is the same as the distance D1.The user may then rotate the optical arm 106 along the pivoting axis 122 to attain a desirable viewing angle.", "In some aspects, to prevent the body 104 from inadvertently moving or otherwise rotating with respect to the base 102, the body 104 may be fixed, secured, or otherwise prevented from moving by either mechanically, electromechanically, or electrically locking the body 104 in the second, inverted configuration.", "For example, as discussed above, the body 104 may be fixed in the inverted configuration by activating the brake.", "The brake may be activated manually by the user or automatically through the use of a controller which is configured to detect the position of the upper or lower portions 104A, 104B of the body 104.When the upper or lower portions 104A, 104B of the body 104 are adjacent to the lower portion 102B of the base 102, the controller activates the brake thereby fixing the body 104 in the inverted configuration.", "The brake may comprise a solenoid, magnetic, electrical, or mechanical brake.", "Alternatively, a pin may be engaged to lock the body 104 to the base 102 in the inverted configuration.", "The user may further remove the handle 126 from either the first or second receptacle 140A, 140B and reinsert the handle 126 in the other receptacle 140A, 140B, as desired.", "The handle 126 may also be inserted into the desired receptacle 140A, 140B from either side of the first or second specimen supporting surfaces 119A, 119B.", "Accordingly, the handle may be arranged so that its position with respect to the user, remains the same (e.g., lower right side of the microscope 100, lower left side of the microscope 100, upper right side of the microscope 100, or upper left side of the microscope 100).", "Once in the inverted configuration, the user may wish to rotate the nose piece 112 in order to utilize a different objective 113.In one aspect, in order to allow the nose piece 112 to freely rotate with sufficient clearance from the stage 114, the stage 114 may be moved from the second position (shown in FIG.", "4B) to the first position (shown in FIG.", "4A).", "In one example, the stage 114 may be moved into the first position by the user.", "In this example, the stage may be mechanically linked to a lever disposed on a sidewall of the body.", "By manipulating the lever, the stage 114 may be moved into the first position.", "In another example, the nosepiece 112 may be mechanically coupled to the stage 114 such that rotation of the nose piece 112 causes the stage 114 to move toward the first position.", "In this example, the nosepiece 112 may be coupled to a rack and pinion mechanism that converts the rotational movement of the nosepiece into a linear displacement of the stage 114.In yet another example, the stage may be coupled to a solenoid that is actuated when rotation of the nosepiece 112 is detected.", "In this example, a controller senses rotation of the nosepiece 112 which in turn causes a signal to be sent to an actuator, such as the solenoid, to thereby actuate the stage 114 away from the objective and into the first position.", "A method for converting the microscope 100 from the inverted configuration into the upright configuration will now be discussed with reference to FIGS.", "1-5.To convert the microscope 100 from the inverted configuration into the upright configuration, the user may first disengage the brake thereby allowing the body 104 to rotate about the rotating axis 120.The user may then rotate the body 104 with respect to the base 102 in either a clockwise or counterclockwise direction along the rotating axis 120, as shown in FIG.", "2.The body 104 is rotated until the second portion 104B is adjacent to the lower portion 102A, as shown in FIG.", "1.As the body 104 is rotated from the inverted configuration into the upright configuration, the stage 114 may automatically slide from the second position (as shown in FIG.", "4B), to the first position (as shown in FIG.", "4A), in a direction along the optical axis 124.As a result, referring to FIGS.", "4A and 4B, the distance between the specimen supporting surface (119A and 119B) and the outer surface of the lens of the objective 113 is maintained.", "In other words, the distance D1 is the same as the distance D2.The user may then rotate the optical arm 106 along the pivoting axis 122 to attain a desirable viewing angle.", "In some aspects, to prevent the body 104 from inadvertently moving or otherwise rotating with respect to the base 102, the body 104 may be locked in the first inverted configuration, as discussed above.", "The user may further remove the handle 126 from either the first or second receptacle 140A, 140B and reinsert the handle 126 in the other receptacle 140A, 140B, as desired.", "The handle 126 may also be inserted into the desired receptacle 140A, 140B from either side of the first or second specimen supporting surfaces 119A, 119B.", "Accordingly, the handle may be arranged so that its position with respect to the user, remains the same (e.g., lower right side of the microscope 100, lower left side of the microscope 100, upper right side of the microscope 100, or upper left side of the microscope 100).", "Flipping Embodiment FIGS.", "6 and 7 illustrate an example of a flipping microscope 200.Similar reference numerals refer to similar or identical structure to the first embodiment 100.Referring to FIG.", "6, the microscope 200 is depicted in an upright configuration.", "The microscope 200 comprises a body 204.The body 204 is configured to support, directly or indirectly, at least one objective 213, a condenser 216, and a light source (not shown).", "The body 204 may further be configured to support a stage 214.The body 204 is configured to be picked up and flipped in order to convert the microscope 200 from an upright configuration (shown in FIG.", "6) to an inverted configuration (shown in FIG.", "7), and vice versa.", "Accordingly, the body 204 comprises flattened upper and lower surfaces, 252A and 252B respectively, that are configured to support the microscope 200 on a working surface 20.The stage 214, if mounted to the body 204, may be mounted to one or more horizontal channels, a mounting block, or a height compensator as described above with reference to the microscope 100.If the stage 214 is mounted to the height compensator 215, the height compensator 215 may be disposed between the objective 213 and the condenser 216.As also described above with reference to the microscope 100, the stage 214 includes an opening aligned with the condenser 216, to allow light to pass through the stage 214 and illuminate the specimen.", "The height compensator 215 permits the stage 214 to slide between a first position and a second position along an optical axis 224, defined by the objective 213.The stage 214 comprises, on an outer surface, a first specimen supporting surface 219A and at an opposite surface, a second specimen supporting surface 219B.", "When the microscope 200 is in the upright configuration the stage 214 is in the first position and the first specimen supporting surface 219A is configured to support the specimen.", "When the microscope 200 is in the inverted configuration the stage 214 is in the second position and the second specimen supporting surface 219B is configured to support the specimen.", "As described above with reference to the microscope 100, when the stage 214 is in the first position, the first specimen supporting surface 219A is positioned at a distance “D1” from an outer surface of a lens of the objective 213.Likewise, when the stage 214 is in the second position, the second specimen supporting surface 219B is positioned at a distance “D2” from the outer surface of the lens of the objective 213.To maintain the appropriate distance between the specimen supporting surface and the objective 213, the height compensator 215 allows the stage 214 to move between the first and second positions.", "By doing so, the height compensator 215 allows D2 to be the same value as D1 when the microscope 200 is flipped from the upright configuration to the inverted configuration.", "Likewise, the height compensator 215 allows D1 to be the same value as D2 when the microscope 200 is flipped from the inverted configuration to the upright configuration.", "In other words, the height compensator 215 maintains the distance (D1 or D2) between the appropriate specimen supporting surface (219A or 219B) and the objective 213, regardless of whether the microscope 200 is in the upright configuration or the inverted configuration.", "Accordingly, the position of a focal plane of the objective 213, with respect to the appropriate specimen supporting surface (219A or 219B), remains unchanged.", "The microscope 200 may further comprise an optical arm 206.The optical arm 206 may be pivotably coupled to the body 204, thereby allowing the optical arm 206 to rotate about a pivoting axis 222.The microscope 200 may further comprise a cradle 208 disposed at a distal portion of the optical arm 206.The cradle 208 is configured to receive and secure an electronic device 210 that is capable of acquiring images.", "A method for flipping the microscope 200 to thereby convert the microscope 200 from an upright configuration into an inverted configuration will now be discussed with reference to FIGS.", "6 and 7.To convert the microscope 200 from the upright configuration (as shown in FIG.", "6) into the inverted configuration (as shown in FIG.", "7), the user picks up and flips the body 204 so that the upper surface 252A makes contact with the working surface 20.The stage 214 automatically slides from the first position to the second position, in a direction along the optical axis 224, as the body 204 is flipped from the upright configuration into the inverted configuration.", "As a result, the distance between the specimen supporting surface (219A and 219B) and the outer surface of the lens of the objective 213 is maintained.", "In other words, the distance D2 is the same as the distance D1.As discussed above with reference to the microscope 100, the user may remove and reposition the handle 226 from either the first or second receptacle 240A, 240B and reinsert the handle 226 in the other receptacle 240A, 240B, as desired.", "The handle 226 may further be inserted into the desired receptacle 240A, 240B from either side of the first or second specimen supporting surfaces 219A, 219B.", "Accordingly, the handle may be arranged so that its position with respect to the user, remains the same (e.g., lower right side of the microscope 200, lower left side of the microscope 200, upper right side of the microscope 200, or upper left side of the microscope 200).", "A method for flipping the microscope 200 to thereby convert the microscope 200 from the inverted configuration into the upright configuration will now be discussed with reference to FIGS.", "6 and 7.To convert the microscope 200 from the inverted configuration (as shown in FIG.", "7) into the upright configuration (as shown in FIG.", "6), the user picks up and flips the body 204 so that the lower surface 252B makes contact with the working surface 20.The stage 214 automatically slides from the second position to the first position, in a direction along the optical axis 224, as the body 204 is flipped from the inverted configuration into the upright configuration.", "As a result, the distance between the specimen supporting surface (219A and 219B) and the outer surface of the lens of the objective 213 is maintained.", "In other words, the distance D1 is the same as the distance D2.The user may remove and reposition the handle 226 from either the first or second receptacle 240A, 240B and reinsert the handle 226 in the other receptacle 240A, 240B, as desired.", "The handle 226 may further be inserted into the desired receptacle 240A, 240B from either side of the first or second specimen supporting surfaces 219A, 219B.", "Accordingly, the handle may be arranged so that its position with respect to the user, remains the same (e.g., lower right side of the microscope 200, lower left side of the microscope 200, upper right side of the microscope 200, or upper left side of the microscope 200).", "Reconfigurable Embodiment FIGS.", "8-10B illustrate an example of a reconfigurable microscope 300.Similar reference numerals refer to similar or identical structure to the first embodiment 100.Referring to FIG.", "8, the microscope 300 comprises a frame or body 304 having a first portion 304A, a second portion 304B and an intermediate portion 304C.", "The intermediate portion 304C is disposed between the first and second portions, 304A and 304B respectively.", "The intermediate portion 304C may be configured to mount a stage 314.The first portion 304A includes a first mounting feature 360A and the second portion 304B includes a second mounting feature 360B.", "Referring to FIG.", "10A, the first and second mounting features, 360A and 360B respectively, each comprise a channel 361 configured to receive interchangeable components.", "The interchangeable components may comprise a nose piece 312 having at least one objective 313, an objective 313, or a light source and condenser assembly 316.Referring to FIG.", "10B, each of the interchangeable components comprises a rail 362 configured to engage the channel 361 of the first and second mounting features, 360A and 360B respectively.", "Accordingly, any of the interchangeable components may engage the first and second mounting features, 360A and 360B respectively.", "Although a channel and rail arrangement is used to mount the interchangeable components to the body 304, it is understood that other methods may be used to mount the interchangeable components to the body 304, such as the use of interference, friction or snap fits, or any other mechanical or electromechanical methods as known by those having ordinary skill in the art.", "Referring to FIGS.", "10A and 10B, in some aspects, each of the first and second mounting features, 360A and 360B respectively, may include a lock 363 configured to mechanically engage the interchangeable components.", "The lock 363 may comprise a tab configured to engage a corresponding indent 364 disposed on each of the interchangeable components.", "The lock 363 may be further configured to automatically engage the indent 364 upon insertion of the interchangeable component into the mounting features 360A and 360B.", "To disengage the lock 363, the tab may be moved to clear the indent 364 while simultaneously moving the interchangeable component away from the body 304.In one aspect, each of the first and second mounting features, 360A and 360B respectively, may include an electrode 366A configured to provide electrical power to those interchangeable components that require power, such as the condenser assembly 316.For example, upon insertion of the condenser assembly 316 into the first or second mounting features, 360A and 360B respectively, a corresponding electrode 366B disposed within the condenser assembly 316 engages the electrode 366A, thereby energizing the light source of the condenser assembly 316.Referring to FIG.", "8, to configure the microscope 300 into an upright configuration, the nose piece 312 may be mounted in the first mounting feature 360A and the condenser assembly 316 may be mounted in the second mounting feature 360B.", "Referring to FIG.", "9, to configure the microscope 300 into an inverted configuration, the nose piece 312 may be mounted in the second mounting feature 360B and the condenser assembly 316 may be mounted in the first mounting feature 360A.", "In some aspects, the nose piece assembly 312 may further comprises an optical arm 306 pivotably coupled to the nose piece 312.The optical arm 306 may therefore, rotate about a pivoting axis 322.The optical arm 306 may further comprise a cradle 308 disposed at a distal portion of the optical arm 306.The cradle 308 is configured to receive and secure an electronic device 310 that is capable of acquiring images.", "Modular Embodiment FIG.", "11A illustrates an isometric view of a modular microscope 400 in the upright configuration.", "FIG.", "11B illustrates an isometric view of the modular microscope 400 in the upright configuration, where dashed lines illustrate interior components.", "FIG.", "11C illustrates a cross-sectional view of the modular microscope 400 in the upright configuration.", "FIG.", "12A illustrates an isometric view of the modular microscope 400 in the inverted configuration FIG.", "12B illustrates an isometric view of the modular microscope 400 in the inverted configuration, where dashed lines illustrate interior components.", "FIG.", "12C illustrates a cross-sectional view of the modular microscope 400 in the inverted configuration.", "Similar reference numerals refer to similar or identical structure to the first embodiment 100.Referring to FIGS.", "11A-11C, the microscope 400 comprises a body 404 having a first portion 404A, a second portion 404B and an intermediate portion 404C.", "The intermediate portion 404C is disposed between the first and second portions, 404A and 404B respectively.", "The intermediate portion 404C may be configured to mount a stage 414.The first portion 404A includes a first mounting feature 460A and the second portion 404B includes a second mounting feature 460B.", "Each of the first and second mounting features, 460A and 460B respectively, are configured to receive an objective module 413 and a condenser module 416.The objective module 413 houses the nose piece 412 and the condenser module 416 houses the condenser 415.The nose piece 412 may be coupled to one or more objectives 412A-C.", "Referring to FIGS.", "13A-13B and 14A-14D, each of the first and second mounting features, 460A and 460B respectively, may comprise slots 461 that are configured to receive corresponding posts 462 disposed in each of the objective and condenser modules, 413 and 416 respectively.", "In some aspects, each of the posts 462 include a latch pin hole 464 that is configured to receive a corresponding latch pin 463 disposed on the body 404.The latch pins 463 provide proper optical alignment of the objective and condenser modules, 413 and 416 respectively, along an optical axis 424 defined by the objective 413.Referring to FIGS.", "13A-13B, the body 404 includes an upper optical port 472A disposed proximate to the first portion 404A and a lower optical port 472B disposed proximate to the second portion 404B.", "Referring to FIGS.", "11A-11C, 12A-12C, and 14C-14D, the upper and lower optical ports, 472A and 472B respectively, are arranged to be aligned with a corresponding optical port 472C of the objective module 413 (shown in FIGS.", "14C-14D) when the microscope 400 is in either the upright configuration (as shown in FIGS.", "11A-11C) or the inverted configuration (as shown in FIGS.", "12A-12C).", "Accordingly, light entering the objective module 413 through nose piece 412 is reflected off of a fixed mirror 480 towards the optical port 472C of the objective module 413 and into the upper or lower optical ports, 472A and 472B respectively.", "Referring to FIGS.", "13A-13B, the body 404 includes an internal optical path 474 that is in communication with the upper and lower optical ports, 472A and 472B respectively.", "The optical path 474 includes a retractable mirror 476A and a fixed mirror 476B.", "The retractable mirror 476A is disposed proximal to the upper optical port 472A and when the retractable mirror 472A is in a first, engaged position, the retractable mirror 472A reflects light entering the upper optical port 472A toward an output port 472D.", "When the retractable mirror 472A is in a second, retracted position, the retractable mirror 472A is moved away from the optical path 474 and does not reflect light in the optical path 474.The fixed mirror 476B is disposed proximal to the lower optical port 472B and is arranged to reflect light entering the lower optical port 472B toward the output port 472D.", "The output port 472D may include supporting optics, such as an ocular lens.", "In other aspects, the output port 472D may comprise a cradle configured to receive an electronic device.", "The electronic device can comprise one of a mobile communications device (e.g., smartphone), tablet computer, laptop computer, PDA, digital camera, portable gaming console, or other portable computing device.", "In one aspect, the retractable mirror 476A may be actuated mechanically or electrically.", "For example, a lever may be manipulated by the user to move the retractable mirror 476A to the first, engaged position or the second, retracted position.", "Alternatively, the retractable mirror 476A may be automatically actuated through detection of the arrangement of the objective module 413 and/or the condenser module 416.For example, each of the objective and condenser modules, 413 and 416 respectively, may have a unique electrical signal that enables a controller to detect whether the objective module 413 or the condenser module 416 is disposed within the first or second mounting features, 460A and 460B respectively.", "Should the controller detect that the objective module 413 is disposed within the first mounting feature 460A, then the retractable mirror 476A is positioned in the first, engaged position.", "Shall the controller detect that the objective module 413 is disposed within the second mounting feature 460B, then the retractable mirror 476A is positioned in the second, retracted position.", "In another example, the retractable mirror 476A may be actuated automatically through an electrical connection made between a particular slot 461 and post 462.For instance, one of the posts 462 may be configured to provide electrical power to a predefined slot 461 that is electrically coupled to a motor or actuator.", "Energizing the motor or actuator thereby causes the retractable mirror 476A to be actuated to the first, engaged position or to the second, retracted position, depending on the arrangement of the objective and condenser modules.", "In another example, the retractable mirror 476A may be actuated through activation of one or more buttons or keys that are disposed on the body 404.In this example, the user may depressed the button or key to cause the retractable mirror 476A to be positioned in the first, engaged position or the second, retracted position via actuation of a motor or actuator coupled to the retractable mirror 476A.", "It is understood that other mechanical or electrical methods, as known by those having ordinary skill in the art, may be used to position the retractable mirror 476A in the first, engaged position or the second, retracted position.", "Referring to FIGS.", "11A-11C, when the microscope 400 is in the upright configuration, the retractable mirror 476A is positioned in the engaged position and reflects light directed from the objective module 413 to the fixed mirror 480 toward the output port 472D.", "Referring to FIGS.", "12A-12C, when the microscope 400 is in the inverted configuration, the retractable mirror 476A is positioned in the retracted position and does not reflect light in the optical path 474.Rather, in the inverted configuration, another fixed mirror 476B reflects light entering the objective module 413 toward the output port 472D.", "Retractable mirror 476A can be coupled to a hinge or pivot 485 to pivot the mirror between the engaged position and the retracted position.", "Referring to FIG.", "14A-14B, the condenser module 416 comprises a structure housing a condenser 415 and light source.", "Referring to FIG.", "14C-14D, the objective module 413 comprises a nose piece 412 onto which at least one objective 412A-C is mounted.", "As discussed above, the objective and condenser modules, 413 and 416 respectively, each comprise posts 462 that are held within corresponding slots 461 in the base 404 by latch pins 463 that are engaged into corresponding latch pin holes 464.In some aspects, the condenser module 416 may be electrically coupled to the base 404 to provide power to the light source.", "In other aspects, the objective module 413 may be electrically coupled to the base 404 to power a focusing mechanism.", "Alternatively, the objective and condenser modules, 413 and 416 respectively, may be self-powered by a battery housed within each of the objective and condenser modules, 413 and 416 respectively.", "Swing Arm Embodiment FIGS.", "15-16B illustrate an example of a swing arm microscope 500.Similar reference numerals refer to similar or identical structure to the first embodiment 100.Referring to FIG.", "15, the microscope 500 comprises a base 502 having an upper portion 502A, a lower portion 502B and an intermediate portion 502C.", "The intermediate portion 502C is disposed between the upper and lower portions, 502A and 502B respectively.", "The intermediate portion 502C may be configured to mount a stage 514.The upper portion 502A includes a first slot 584A and the lower portion 502B includes a second slot 584B.", "The first slot 584A is configured to receive an upper swing arm 504A and the second slot 584B is configured to receive a lower swing arm 504B.", "Each of the upper and lower swing arms, 504A and 504B respectively, are configured to swing within their corresponding slots, 584A and 584B respectively, along a pivoting axis 588 defined by a spindle 582.In one aspect, the pivoting axis is disposed along a plane of symmetry of the upper and lower swing arms 504A, 504B.", "Referring to FIG.", "15, the spindle 582 is disposed within the base 502.The upper and lower swing arms, 504A and 504B respectively, are pivotably coupled to the spindle 582 via rotational mounts 583 (as shown in FIGS.", "16A and 16B).", "In one aspect, the upper and lower swing arms, 504A and 504B respectively, swing together because each is coupled to the same spindle 582.Accordingly, the upper and lower swing arms, 504A and 504B respectively, move together about the pivoting axis 588.Referring to FIGS.", "16A and 16B, each of the upper and lower swing arms 504A, 504B include an objective 513 and a condenser 516.The upper and lower swing arms 504A, 504B may have similar profiles such as, for example, an “L” shaped, square shaped, or round shaped profile.", "Although the objective 513 and the condenser 516 of each swing arm 504A, 504B are depicted as being 90 degrees apart, it is understood that other angles may be used without departing from the scope of this disclosure.", "For example, the objective 513 and the condenser 516 of each swing arm 504A, 504B may be disposed at any angle ranging from 10-180 degrees.", "In some aspects, the pivoting axis 588 may be disposed between the objective 513 and the condenser 516 of the upper and lower swing arms 504A, 504B.", "Referring to FIG.", "16A, the upper swing arm 504A includes a first optical port 577A and a second optical port 577C.", "The first optical port 577A includes a mirror 576A that is configured to reflect light entering the objective 513 of the upper swing arm 504A toward an optical path 574 disposed within the base 504 (shown in FIG.", "15).", "The second optical port 577C comprises a through hole that allows light entering the objective 513 of the lower swing arm 504B to exit an output port 572.Referring to FIG.", "15, the output port 572 may include supporting optics, such as an ocular lens and may comprise a cradle configured to receive an electronic device.", "Referring to FIG.", "16B, the lower swing arm 504B includes an optical port 577B.", "The optical port 577B includes a pair of mirrors 576A, 576B that is configured to reflect light entering the objective 513 of the lower swing arm 504B toward the optical path 574 of the base 504 (shown in FIG.", "15).", "In one aspect, because each swing arm 504A, 504B includes an objective 513 and condenser 516, conversion of the microscope 500 from an upright configuration to an inverted configuration, or vice versa, simply requires that the swing arms 504A, 504B be arranged so that the objective 513 and condenser 516 are positioned according to the desired configuration.", "For example, shall the user desire to use the microscope 500 in an upright configuration, the user would position the swing arms 504A, 504B so that the objective 513 of the upper swing arm 504A is disposed above the specimen to be observed and the condenser 516 of the lower swing arm 504B is disposed below the specimen to be observed.", "As discussed above, because the upper and lower swing arms, 504A and 504B, are coupled to the same spindle 582, rotation of one of the swing arms 504A, 504B causes rotation of the other swing arm 504A, 504B.", "In this example, after light enters the objective 513 of the upper swing arm 504A, light is reflected and directed toward the first optical port 577A via the mirror 576A.", "Light exiting the first optical port 577A enters the optical path 574 of the base 504 and exits from the output port 572.In another example, should the user desire to use the microscope 500 in an inverted configuration, the user would position the swing arms 504A, 504B so that the objective 513 of the lower swing arm 504B is disposed below the specimen to be observed and the condenser 516 of the upper swing arm 504A is disposed above the specimen to be observed.", "Again, because the upper and lower swing arms, 504A and 504B, are coupled to the same spindle 582, rotation of one of the swing arms 504A, 504B causes rotation of the other swing arm 504A, 504B.", "In this example, after light enters the objective 513 of the lower swing arm 504B, light is reflected and directed toward the optical port 577B via the mirror 576B.", "Light exiting the optical port 577B enters the optical path 574 of the base 504, passes through the second optical port 577C of the upper swing arm 504A, and ultimately exits from the output port 572.The cradle 608 configured to receive and secure an electronic device 610 that is capable of acquiring images, and to align an optical element of the electronic device 610 with the output port 572.The electronic device 610 can be a portable personal computing device including an optical element (e.g., a camera), for example a mobile communications device (e.g., smartphone), tablet computing device, laptop, PDA, portable gaming device, camera, or other portable computing device with imaging capabilities.", "Accordingly, the objective 513 of the upper swing arm 504A is used when the microscope 500 is in the upright configuration and the condenser 516 of the upper swing arm 504A is used when the microscope 500 is in the inverted configuration.", "Similarly, the objective 513 of the lower swing arm 504B is used when the microscope 500 is in the inverted configuration and the condenser 516 of the lower swing arm 504B is used when the microscope 500 is in the upright configuration.", "Laterally Rotating Embodiment FIG.", "17A illustrates an example of a laterally rotating microscope 600 in an upright configuration, and FIG.", "17B illustrates an example of the laterally rotating microscope 600 in an inverted configuration.", "Similar reference numerals refer to similar or identical structure to the first embodiment 100.Referring to FIGS.", "17A-17B, the microscope 600 comprises a base 602 and a rotating assembly 604.The rotating assembly 604 may include an objective 613, an optical arm 606, a cradle 608, a stage 614, and a condenser 616, that are all configured to rotate together as a single assembly, along a rotating axis 620 that extends along a lateral direction with respect to the microscope 600.The rotating axis 620 is defined by rotational couplings disposed at opposite ends of the stage 614.In one aspect, the optical arm 606 may be coupled to the objective 613 and configured to reflect light entering the objective 613 toward an optical input of an electronic device 610.The electronic device 610 may be removably attached to the optical arm 606 via the cradle 608.The objective 613 and the condenser 616 are connected by a structural arm 692.The structure arm 692 supports and arranges the objective 613 and the condenser 616 with respect to the stage 614.As shown in FIGS.", "17A-17B, the objective 613 and condenser 616 may be arranged at opposing ends of the structure arm 692.To convert the microscope 600 into an inverted configuration, a handle 694 of the rotating assembly 604 is rotated along the rotating axis 620 until the handle 694 engages a slot 696 disposed within the base 602.As a result of such rotation, the rotating assembly 604 is rotated about 180 degrees, thereby positioning the objective 613 below the stage 614 and the condenser 616 above the stage 614.As discussed above with reference to the stage 114, the stage 614 may be configured to support a specimen on both a first and second specimen supporting surface.", "Overview of Example Controller and User Interface Components FIG.", "18 is a block diagram illustrating components of controller 1000 that can be used to manage a dual-use microscope.", "The controller 1000 can be integral to the microscope in some embodiments.", "In other embodiments, the controller 1000 can be separate from the microscope, for example the controller 1000 can be included in a user portable computing device (e.g., smartphone, tablet, laptop, personal digital assistant, or the like) configured to communicate and/or cooperate with the microscope.", "In further embodiments, aspects of the controller 1000 can be integral to the microscope and aspects of the controller 1000 can be separate from the microscope.", "Controller 1000 comprises user interface module 1020, processor module 1004, storage module 1010, input/output (I/O) module 1008, memory module 1006, and bus 1002.Bus 1002 may be any suitable communication mechanism for communicating information.", "Processor module 1004, storage module 1010, I/O module 1008, and memory module 1006 are coupled with bus 1002 for communicating information between any of the modules of controller 1000 and/or information between any module of controller 1000 and a device external to controller 1000.For example, information communicated between any of the modules of controller 1000 may include instructions and/or data.", "In some aspects, bus 1002 may be a universal serial bus.", "In some aspects, bus 302 may provide Ethernet connectivity.", "User interface module 1020 can generate a graphical user interface for enabling user interaction with the dual-configuration microscope and/or image data gathered from the dual-configuration microscope, and includes image parameters adjustment module 1022 and file management module 1024.User interface module 1020 can be available as a set of software instructions, for example an application that can be downloaded or otherwise provided to an electronic device configured to be received by the cradle of the optical arm of the dual-configuration microscope to acquire images.", "The image parameters adjustment module 1022 can provide functionality for a user to adjust the brightness, contrast, and color settings of acquired images.", "The file management module 1024 can provide functionality for naming and archiving of acquired images.", "For example, for archiving the file management module 1024 can provide controls for naming a file, naming an album, and choosing which file type to use for saving an acquired image (e.g., .jpeg, .tiff, .png).", "For example, for file sharing the file management module 1024 can provide functionality to send an acquired image by email or other electronic communication, to interface with and upload to a local network server, or to share using global network filesharing services.", "In some aspects, processor module 1004 may comprise one or more processors, where each processor may perform different functions or execute different instructions and/or processes.", "For example, one or more processors may execute instructions for focusing on a specimen, positioning a specimen with respect to an objective, operating of a light source, controlling of a condenser, acquiring an image, processing an image, sending an image to another device, altering light pathways and illumination settings, automated X-Y stage movement, controlling external hardware devices (e.g., camera), controlling other computer devices (e.g., onboard mini-computer, onboard controllers), communicating with another device, and one or more processors may execute instructions for input/output functions.", "Memory module 1006 may be random access memory (“RAM”) or other dynamic storage devices for storing information and instructions to be executed by processor module 1004.Memory module 1006 may also be used for storing temporary variables or other intermediate information during execution of instructions by processor 1004.In some aspects, memory module 1006 may comprise battery-powered static RAM, which stores information without requiring power to maintain the stored information.", "Storage module 1010 may be a magnetic disk or optical disk and may also store information and instructions.", "In some aspects, storage module 1010 may comprise hard disk storage or electronic memory storage (e.g., flash memory).", "In some aspects, memory module 1006 and storage module 1010 are both a machine-readable medium.", "Controller 1000 is coupled via I/O module 1008 to a user interface for providing information to and receiving information from a user controlling functions of a microscope, operations of a microscope, or for causing actuation of certain components of a microscope (e.g., movement of a retractable mirror, stage, or objective).", "For example, the user interface may be a cathode ray tube (“CRT”), LCD monitor, or touch-screen display for displaying information to an operator.", "The user interface may also include, for example, a keyboard, a mouse, or a touch-screen device coupled to controller 1000 via I/O module 1008 for communicating information and command selections to processor module 1004.According to various aspects of the subject disclosure, methods described herein are executed by controller 1000.Specifically, processor module 1004 executes one or more sequences of instructions contained in memory module 1006 and/or storage module 1010.In one example, instructions may be read into memory module 1006 from another machine-readable medium, such as storage module 1010.In another example, instructions may be read directly into memory module 1006 from I/O module 1008, for example from a user controlling functions of a microscope, operations of a microscope, or for causing actuation of certain components of a microscope (e.g., movement of a retractable mirror, stage, or objective) via the user interface.", "Execution of the sequences of instructions contained in memory module 1006 and/or storage module 1010 causes processor module 1004 to control functions of the microscope, operations of the microscope, or actuation of certain components of the microscope (e.g., movement of a retractable mirror, stage, or objective).", "For example, focusing operations, image processing and acquisition, and component actuation instructions may be stored in memory module 1006 and/or storage module 1010 as one or more sequences of instructions.", "Information such as the distance between a specimen supporting surface and a condenser, or position of an objective or condenser with respect to a specimen may be communicated from processor module 1004 to memory module 1006 and/or storage module 1010 via bus 1002 for storage.", "In some aspects, the information may be communicated from processor module 1004, memory module 1006, and/or storage module 1010 to I/O module 1008 via bus 1002.The information may then be communicated from I/O module 1008 to a user operating the microscope.", "One or more processors in a multi-processing arrangement may also be employed to execute the sequences of instructions contained in memory module 1006 and/or storage module 1010.In some aspects, hard-wired circuitry may be used in place of or in combination with software instructions to implement various aspects of the subject disclosure.", "Thus, aspects of the subject disclosure are not limited to any specific combination of hardware circuitry and software.", "The term “machine-readable medium,” or “computer-readable medium,” as used herein, refers to any medium that participates in providing instructions to processor module 1004 for execution.", "Such a medium may take many forms, including, but not limited to, non-volatile media, volatile media, and transmission media.", "Non-volatile media include, for example, optical or magnetic disks, such as storage module 1010.Volatile media include dynamic memory, such as memory module 1006.Common forms of machine-readable media or computer-readable media include, for example, floppy disk, a flexible disk, hard disk, magnetic tape, any other magnetic medium, a CD-ROM, DVD, any other optical medium, punch cards, paper tape, any other physical mediums with patterns of holes, a RAM, a PROM, an EPROM, a FLASH EPROM, any other memory chip or cartridge, or any other medium from which a processor can read.", "FIG.", "19 illustrates and example of a user interface 1900 provided on a computing device configured to cooperate, at least optically and in some examples electronically, with a dual-configuration microscope.", "The user interface 1900 can be generated in some embodiments by the user interface module 1020 of the controller 1000.As illustrated, the user interface includes a specimen display area 1930, an image parameter control panel 1910, and file naming controls 1920, 1925.The specimen display area 1930 displays to a user a visual representation of the specimen positioned in the optical path of the microscope.", "In some embodiments, the visual representation can be adjusted by the user, for example by zooming, rotating, or using other adjustment controls presented in the image parameter control panel 1910.In other aspects, the visual representation of the specimen can be received by a camera of the device used to present the interface 1900.For example, an electronic device positioned in the cradle of a microscope, as described above, may convert the visual representation of the specimen into a digital representation, and present that digital representation in the specimen display area 1930 via a touch sensitive display panel.", "Image parameter control panel 1910 can provide functionality for a user to change the visual appearance of one or more image parameters of the specimen image including, for example, brightness controls 1912, contrast controls 1914, and color option selections 1916, among others.", "The image parameter control panel 1910 can also provide a file type selection functionality 1918 for a user to change a file type to be used for storage of a snapshot of the visual representation of the specimen.", "The user may capture a snapshot of the visual representation of the specimen by activating a shutter button.", "For example, the interface 1900 can be presented on a touch-sensitive display panel in some embodiments, and a user may capture a snapshot of the visual representation of the specimen by touching a digital shutter button.", "For archiving, the interface 1900 may provide controls for naming the file 1925, naming the album 1930, and choosing which file type to save as (.jpeg, .tiff, .png) as described above.", "Such functionality can beneficially enable a user of the microscope to organize snapshots using a personalized system to enable easier retrieval of a desired specimen snapshot stored in an electronic database after storage, for example by naming the album based on session date, specimen type, or others, and by naming the files based on sample characteristics, image parameters, or the like, to name just a few examples.", "Although not illustrated, the interface 1900 can provide for file sharing capabilities, for example enabling a user to send specimen snapshot images by email, directly upload to and interface with a local network server, or share using a networked file-sharing service.", "The interface 1900 can, in some embodiments, provide post processing tools for editing specimen snapshots after image capture, for example by cropping and making image parameter adjustments.", "The interface 1900 can also include analysis tools, for example for counting, labeling, rotating, and/or making measurements on captured specimen snapshots.", "Overview of Additional Components of Rotating Embodiments FIG.", "20A illustrates a top, left, and front perspective view of a stage 2000 and FIG.", "20B illustrates a bottom, right, and front perspective view of the stage 2000.As illustrated in FIGS.", "20A-20B, an embodiment of an X-Y stage 2000 for use with a dual-configuration microscope such as is described herein may include a mounting block 2005 configured to be inserted into a corresponding pocket 2010 disposed within the intermediate portion 104C of the body of a dual-configuration microscope.", "In some embodiments, the X-Y stage 2000 can be used with any of the dual-configuration microscopes described herein, for example the rotatable microscope embodiments, modular microscope embodiments, and reconfigurable microscope embodiments discussed herein.", "In the illustrated example, the mounting block 2005 of the stage 2000 can be inserted into the pocket 2010 and held into position by a quick release mechanism 2015.The quick release mechanism 2015 may comprise, in the illustrated embodiment, a chamfered rotating member 2020 and handle 2025, wherein the chamfered rotating member 2020 is configured to securely engage a corresponding chamfer 2030 on the mounting block 2005.As the quick release mechanism 2015 is rotated, a contact force between the chamfers 2020 and 2030 increases to thereby securely engage and maintain the mounting block 2005 in position.", "Other suitable releasable securing mechanisms can be used in other embodiments.", "As illustrated in FIGS.", "21B and 21C, the specimen supporting surface 2035 of the stage 2000 is mounted at or below a horizontal central axis 2040 of the mounting block 2005.The central axis 2040 of the mounting block 2005 passes through the vertical center of the mounting block 2005.In some aspects, the spatial relationship between the horizontal central axis 2040 of the mounting block 2005 and the specimen supporting surface 2035 enables a spacing between the specimen supporting surface 2035 of the stage 2000 and an outer surface of a lens of the objective and/or an outer surface of the condenser to be maintained, regardless of whether the microscope is in the upright or inverted configuration, as discussed above with reference to FIGS.", "4A and 4B.", "To illustrate, when the microscope is in the upright configuration and after the stage 2000 is inserted into the pocket 2010 and secured, the specimen supporting surface 2035 is positioned a distance away from the outer surface of the lens of the objective 2125 and/or the outer surface of the condenser 2130 (represented by D5).", "When the microscope is in the inverted configuration and the stage 2000 is inserted into the pocket 2010 and secured, the specimen supporting surface 2035 is positioned substantially the same distance away from the outer surface of the lens of the objective 2125 and/or the outer surface of the condenser 2130 (represented by D6).", "Distances D5 and D6 may be equal or substantially equal.", "Thereby, the focal distance between the specimen supporting surface 2035 and outer surface of the lens of the objective can be maintained in some embodiments regardless of whether the microscope is in the upright or inverted configuration.", "In some embodiments, the spatial relationship between the horizontal central axis 2040 of the mounting block 2005 and the specimen supporting surface 2035 enables a spacing or working distance between the specimen supporting surface 2035 of the stage 2000 and an outer surface of a lens of the condenser 2130 of the microscope to be maintained regardless of whether the microscope is in the upright or inverted configuration.", "As illustrated by FIG.", "21B and FIG.", "21C, the body of the microscope occupies substantially the same three-dimensional area in the inverted configuration and in the upright configuration, and faces substantially the same direction in the inverted configuration and in the upright configuration.", "In the inverted configuration, the objective occupies substantially the same space as the condenser occupies in the upright configuration.", "Similarly, in the inverted configuration, the condenser occupies substantially the same space as the objective occupies in the upright configuration.", "This can provide a seamless user experience when converting the microscope between the upright and inverted configurations, as the microscope occupies substantially the same space above the workspace upon which the microscope is placed in both configurations, and also faces the same direction in both configurations As in the illustrated embodiment, the stage 1900 can be configured to be removed during transition of the microscope between the inverted and upright configurations.", "In other embodiments, the stage 2000 and pocket 2010 can be coupled to the base of the microscope such that the body of the microscope can rotate between the inverted and upright configurations without removal of the stage 2000.The illustrated specimen supporting surface 2035 of the stage 2000 includes an insert 2045 for holding two standard sized slides for an inverted microscope.", "In other embodiments, different slide inserts can be used instead of the illustrated insert 2045.The insert can be removable, and can be replaced with an insert for holding a specimen dish or container when the microscope is in the upright configuration.", "The stage 2000 can be controlled in some embodiments by rotation of a Y-axis knob 2050 and an X-axis knob 2055 for driving belt 2060 for laterally positioning at least an upper structure 2065 of the stage 2000 in the Y and X directions, respectively, enabling acquisition of images of different portions of the samples supported by the insert 2045.Upper structure 2065 may comprise belts, gears, or other comparable mechanisms that enable at least the specimen supporting surface 2035 to move in the Y and X directions.", "In other embodiments, the stage 2000 can be additionally or alternatively controlled through use of a digital controller, for example through controller 1000 communicating with X and Y drive motors (not illustrated) of the stage 2000.FIGS.", "21A through 21C illustrate another embodiment of rotating microscope 2100 comprising a body rotatably coupled with a unitary base.", "The body 2105 includes at least one contoured surface.", "For example, the upper and lower surfaces of the body 2105 may each have a convex profile that corresponds to a concave profile of an outer surface of the lower portion of the base, facilitating smooth rotation of the body.", "FIG.", "21A illustrates an isometric view of the microscope 2100 with the body in an upright configuration.", "The body 2100 includes the stage 2000 described above, and an optical arm 2110 with a rotatable collar 2199, a first geared focus module 2115 for the objective 2125, and a second geared focus module 2120 for the condenser 2130.FIG.", "21B illustrates a front view of the rotatable microscope 2100 in the upright configuration with the first geared focus module 2115 and a lower casing of the optical arm 2110 removed to reveal the components of the optical path 2190 inside of the optical arm 2110.The optical arm 2110 includes a rotatable collar 2199 and a Dove prism 2135 (shown in FIG.", "21D) positioned to receive light representing acquired images and pass the light to the reflective surface 2140, which then redirects the light through the eyepiece 2155 of the optical arm 2110.The optical arm 2110 can be rotatably coupled to the body 2105 in some embodiments.", "Due to rotation of the optical arm 2110 around the optical path 2190 passing through the optical arm 2110, the acquired specimen image can be rotated when viewed by an imaging device in optical communication with the eyepiece 2155 of the optical arm 2110.Advantageously, the Dove prism 2135 is located in the optical path 2190 and can be longitudinal rotated, automatically and/or manually, in order to correct for rotation of the acquired image.", "For example, the Dove prism 2135 can be manually rotated in some embodiments by rotation of the collar 2199.FIG.", "21C illustrates an embodiment of the rotatable microscope 2100 with the body positioned in an inverted configuration.", "FIG.", "21D illustrates a close up view of the Dove prism 2135 within a housing 2175.The housing 2175 may rotate at a different rate than the optical arm 2110 in some embodiments.", "The Dove prism 2135 is a type of reflective prism which can be used to invert an image.", "The Dove prism 2135 is shaped from a truncated right-angle prism.", "A beam of light entering a first face 2160 of the sloped faces of the prism undergoes total internal reflection from the inside of the longest face 2165 and emerges from the opposite sloped face 2170.Images passing through the prism 2135 are flipped, and because only one reflection takes place, the image is inverted but not laterally transposed.", "Properties of the Dove prism 2135 make it useful as a beam rotator, as when the prism 2135 is rotated along its longitudinal axis 2195, the transmitted image rotates at twice the rate of the prism 2135.Accordingly, longitudinal rotations of the prism 2135 can cause double the rotation of the acquired image to correct for rotation of visual representations of specimens due to rotation of the microscope and/or optical arm.", "The longitudinal axis 2195 of the Dove prism 2135 can be aligned with the optical path 2190 in some embodiments.", "In some embodiments, the Dove prism 2135 is disposed within the housing 2175 comprising an inner tube, the inner tube 2175 is disposed within an outer tube 2185.The inner tube 2175 and outer tube 2185 are coaxially arranged.", "Rotation of the inner tube 2175 can be accomplished by rotation of a collar 2199 that may be disposed at substantially one end of the inner tube 2175.In some aspects, the collar 2199 may be coupled to the inner tube 2175 via a threaded engagement, press fit, or other comparable mechanical coupling methods know to a person of ordinary skill.", "Rotation of the collar 2199 thereby causes rotation of the inner tube 2175, which in turn causes rotation of the Dove prism 2135.Additionally or alternatively, the Dove prism 2135 may be rotated automatically with the use of gears that are arranged to rotate the inner tube 2175 as the optical arm 2110 is rotated.", "As one example, the gears may be arranged to provide a gearing ratio of 2:1, where one full rotation of the optical arm 2110 causes one-half rotation of the Dove prism 2135.Other gearing ratios may be acceptable, depending on the intended design.", "In other aspects, a user may further manually rotate the inner tube 2175 to attain a desired rotation of the acquired image.", "In other aspects, rotation of the Dove prism 2135 may be accomplished via a stepper, rotational, or linear motor, for example, driven by controller 1000.In yet another example, a stepper, rotational, or linear motor may be actuated based on an accelerometer reading of the electronic device coupled to the optical arm 2110.In some embodiments, the Dove prism 2135 as described above can be used with any of the dual-configuration microscopes described herein, for example the rotatable microscope embodiments, modular microscope embodiments, and reconfigurable microscope embodiments discussed herein.", "Tilting Embodiment FIGS.", "22-25E illustrate an example of a tilting microscope 2200 having a plurality of planar surfaces 2204A-E.", "Similar reference numerals refer to similar or identical structure to the first embodiment 100.Referring to FIG.", "22, the microscope 2200 comprises a body 2202.The body 2202 is configured to support, directly or indirectly, a nosepiece 2212, at least one objective 2213, a condenser 2216, and a light source (not shown).", "The body 2202 may further be configured to support a stage 2214.In some aspects, the condenser 2216 of the microscope 2200 may be selected based on the configuration of the microscope 2200.The condenser 2216 may be one of a high-resolution or upright condenser having a focal length of 1-4 mm, a long working distance condenser having a focal length of 35-2 mm, or an ultra-long working distance condenser having a focal length of 70-73 mm, depending on the configuration of the microscope 2200.For example, if the microscope 2200 is in an upright configuration, the condenser 2216 may be a high-resolution condenser.", "If the microscope 2200 is in an inverted configuration, the condenser 2216 may be replaced with a long working distance condenser.", "The stage 2214 comprises, on an outer surface, a first specimen supporting surface 2219A and at an opposite outer surface, a second specimen supporting surface 2219B.", "When the microscope 2200 is in the upright configuration (as shown in FIGS.", "23A-B) the first specimen supporting surface 2219A is configured to support a specimen.", "When the microscope 2200 is in the inverted configuration (as shown in FIGS.", "24A-B) the second specimen supporting surface 2219B is configured to support the specimen.", "In one aspect, the stage 2214 may be configured to removably receive an X-Y adaptor that allows the specimen to move in a controlled fashion along the X and Y axes.", "The removable X-Y adaptor may be configured to attach to the stage 2214 to allow use of the first specimen supporting surface 2219A or the second specimen supporting surface 2219B, depending on the configuration of the microscope 2200 and the surface of the stage 2214 upon which the removable X-Y adaptor is mounted or attached.", "The microscope 2200 may further comprise a first and second mounting slot 2206A, B, with the first mounting slot 2206A disposed on a first planar surface 2204A and the second mounting slot 2206B disposed opposite of the first mounting slot 2206A, on a planar surface, such as planar surface 2204E.", "Each of the mounting slots 2206A, B are configured to receive and support a portable display device, such as portable display device 2210 as shown in FIGS.", "23A and 24A.", "For example, each mounting slot 2206A, B may be configured to receive a side or end of the portable display device and support the portable display device to enable a user to view and use the portable display device, as desired.", "In one aspect, the microscope 2200 may further comprise a first and second rotating stand 2208A, B, as shown in FIGS.", "22, 23B and 24B.", "The first rotating stand 2208A may be disposed on the first planar surface 2204A and the second rotating stand 2208B may be disposed opposite of the first mounting rotating stand 2208A, on a planar surface, such as planar surface 2204E.", "Each of the rotating stands 2208A, B are configured to support a portable display device, such as portable display device 2210 as shown in FIGS.", "23A-24B, when positioned in a deployed configuration.", "Each rotating stand 2208A, B may be pivotably coupled to the body 2202 and configured to rotate between the deployed configuration and a stowed configuration.", "When in the deployed configuration, each rotating stand 2208A, B mechanically supports the portable display device.", "When in the stowed configuration, each rotating stand 2208A, B lays substantially flush with its respective surrounding surface, 2204A, E. In one aspect, each rotating stand 2208A, B may be biased to the stowed position via a spring or other mechanism as would be known by a person of ordinary skill, to ensure that each rotating stand 2208A, B is maintained in the stowed configuration when the microscope 2200 is titled between an upright to inverted configuration, and vice versa.", "Referring to FIGS.", "23A-24B, in some aspects, the portable display device 2210 may comprise a mobile device, camera, tablet computer, laptop computer, PDA, portable computer, or other device that is capable of displaying images.", "The portable display device 2210 may further comprise a touch-sensitive screen display or other input mechanisms, such as buttons or keys, that are capable of receiving user input.", "In some aspects, a user may control operations of the microscope 2200, such as focusing of a specimen, positioning of a specimen with respect to the objective 2213, operation of the light source, control of the condenser 2216, acquisition of an image, processing of an image, storing of an image, sending of an image to another device, altering light pathways and illumination settings, automated X-Y stage movement, automated nosepiece movement, controlling external hardware devices (e.g., camera), controlling other computer devices (e.g., onboard mini-computer, onboard controllers), communicating with other devices (such as through local area networks, wide area networks, broadband, Bluetooth, WiFi, or other wireless or wired communication methods), and other microscope related operations, by using the input mechanisms of the electronic device 110.In one aspect, the microscope 2200 may comprise an internal camera or light sensor (not shown) that is configured to receive light that has entered the objective 2213.The internal camera or light sensor may be configured to detect and convey information that constitutes an image by converting variable attenuation of light waves as they pass through or reflect off of the specimen into digital signals.", "The internal camera or light sensor may comprise a semiconductor charge-coupled device (CCD), active pixel sensor in complementary metal-oxide-semiconductor (CMOS), or an N-type metal-oxide-semiconductor (NMOS, Live MOS).", "In one aspect, the internal camera or image sensor may be coupled to a communications module that is configured to receive data representing the light received by the camera or sensor and transmit the data to the portable display device 2210.The data may be transmitted to the portable display device via a wired or wireless connection.", "The data received by the portable display device 2210 may then be displayed to the user as one or more images.", "The microscope 2200 further comprises a plurality of planar surfaces 2204A-E that are each configured to support the microscope 2200 on a working surface as the microscope 2200 is converted from an upright configuration to an inverted configuration, and vice versa.", "For example, the plurality of planar surfaces 2204A-E may be configured to facilitate tilting of the microscope 2200 as the microscope is converted from an upright configuration (as shown in FIGS.", "23A-B) to an inverted configuration (as shown in FIGS.", "24A-B), and vice versa, as illustrated in FIGS.", "25A-E.", "The plurality of planar surfaces 2204A-E may be disposed on the body 2202 and configured to support the microscope 2200 and allow tilting of the microscope 2200 as the microscope 2200 is tilted from one planar surface, to an adjacent planar surface.", "For example, the microscope 2200 may comprise five planar surfaces, with a first planar surface 2204A disposed parallel to the stage 2214, a second planar surface 2204B disposed at an angle less than 90 degrees from the first planar surface 2204A, a third planar surface 2204C disposed perpendicularly from the first planar surface 2204A, a fourth planar surface 2204D disposed at an angle less than 90 degrees from the third planar surface 2204C, and a fifth planar surface 2204E disposed parallel to the stage 2214.In one example, the angle between the first planar surface 2204A and the second planar surface 2204B may be 30 degrees, 45 degrees, 60 degrees, or any angle there between.", "In another example, the angle between the fourth planar surface 2204D and the third planar surface 2204C may be 30 degrees, 45 degrees, 60 degrees, or any angle there between.", "In yet another example, the angle between the first planar surface 2204A and the second planar surface 2204B may be substantially the same angle as an angle between the fifth planar surface 2204E and the fourth planar surface 2204D.", "The microscope 2200 may further comprise a plurality of focus knob receptacles 2217-D that are each configured to receive a removable focus knob 2218 (shown in FIGS.", "22 and 23A-24B).", "The focus knob receptacles 2217A-D may be disposed laterally on both outward sides of the body 2202.For example, referring to FIGS.", "22 and 23A, B, a first focus knob receptacle 2217A may be disposed proximal to the nosepiece 2212 and right side of the body 2202, and a second focus knob receptacle 2217B may be disposed proximal to the condenser 2216 and right side of the body 2202.Referring to FIGS.", "24A, B, a third focus knob receptacle 2217C may be disposed proximal to the condenser 2216 and opposite side of the body 2202, and a fourth focus knob receptacle 2217D may be disposed proximal to the nosepiece 2212 and opposite side of the body 2202.In one aspect, depending on the configuration of the microscope 2200 and preference of the user, the focus knob 2218 may be inserted in any of the focus knob receptacles 2217A-D to adjust a position of the objective 2213, adjust a position of the stage 2214, adjust the position of the condenser 2216, or control operations of the microscope 2200.The focus knob 2218 may further comprise one or more buttons or user input mechanisms to receive user input or commands for controlling or operating the microscope.", "In some aspects, a user may use the focus knob 2218 to focus a specimen, position a specimen with respect to the objective 2213, operate a light source, control the condenser 2216, acquire an image, process an image, send an image to another device, alter light pathways and illumination settings, control external hardware devices (e.g., camera), control other computer devices (e.g., onboard mini-computer, onboard controllers), communicate with other devices (such as through local area networks, wide area networks, broadband, Bluetooth, WiFi, or other wireless or wired communication methods), and other microscope related operations, by using the input mechanisms of the focus knob 2218.The focus knob 2218 may further comprise an internal rechargeable battery and wireless communication module that enables the focus knob 2218 to communicate with the microscope 2200 and/or portable display device 2210.FIGS.", "23A and 23B illustrate the microscope 2200 positioned in the upright configuration.", "In the upright configuration, the body is positioned such that the nosepiece assembly 2212 is positioned vertically above the stage 2214 and the condenser is positioned vertically below the stage 2214.The first specimen supporting surface 2219A is positioned to support the specimen.", "While any focus knob receptacle 2217A-D may be used to mount the focus knob 2218, for ergonomic purposes and depending on whether the user prefers to use their right or left hand, the second focus knob receptacle 2217B or third focus knob receptacle 2217C may be used to mount the focus knob 2218.First mounting slot 2206A and first rotating stand 2208A may be used to mount and support the portable display device 2210.FIGS.", "24A and 24B illustrate the microscope 2200 positioned in the inverted configuration.", "In the inverted configuration, the body is positioned such that the nosepiece assembly 2212 is positioned vertically below the stage 2214 and the condenser is positioned vertically above the stage 2214.The second specimen supporting surface 2219B is positioned to support the specimen.", "While any focus knob receptacle 2217A-D may be used to mount the focus knob 2218, for ergonomic purposes and depending on whether the user prefers to use their right or left hand, the first focus knob receptacle 2217A and fourth focus knob receptacle 2217D may be used to mount the focus knob 2218.Second mounting slot 2206B and second rotating stand 2208B may be used to mount and support the portable display device 2210.A method for converting the microscope 2200 from the upright configuration into the inverted configuration will now be discussed with reference to FIGS.", "25A-E. To convert the microscope 2200, the portable display device 2210 is dismounted, thereby allowing the rotating stand 2208A to move to the stowed position.", "Referring to FIG.", "25A, while in the upright configuration the microscope 2200 is supported by the fifth planar surface 2204E.", "To convert the microscope 2200 from the upright configuration into the inverted configuration, the user first tilts the microscope 2200 toward the fourth planar surface 2204D.", "Referring to FIG.", "25B, the microscope 2200 is shown in an intermediate position as the microscope 2200 rests on the fourth planar surface 2204D.", "The user then continues the conversion process by titling the microscope 2200 toward the third planar surface 2204C.", "Referring to FIG.", "25C, the microscope 2200 is shown in an intermediate position as the microscope 2200 rests on the third planar surface 2204C.", "The user then continues the conversion process by titling the microscope 2200 toward the second planar surface 2204B.", "Referring to FIG.", "25D, the microscope 2200 is shown in an intermediate position as the microscope 2200 rests on the second planar surface 2204B.", "The user then finishes the conversion process by titling the microscope 2200 toward the first planar surface 2204A.", "Referring to FIG.", "25E, the microscope 2200 is shown in the inverted position as the microscope 2200 rests on the first planar surface 2204A.", "The user may then mount the portable display device 2210 to the microscope 2200 by using the second mounting slot 2206B and positioning the second rotating stand 2208B to the deployed configuration.", "The user may further reposition the focus knob 2218 to whichever focus knob receptacle 2217A-D is desired.", "While this example conversion of the microscope may involve tilting the microscope 2200 up to four instances and using five planar surfaces 2204A-E, it is understood that fewer or more tilting instances and planar surfaces may be used to convert the microscope from the upright configuration to the inverted configuration without departing from the scope of the invention.", "A method for converting the microscope 2200 from the inverted configuration into the upright configuration will now be discussed with reference to FIGS.", "25A-E. To convert the microscope 2200, the portable display device 2210 is dismounted, thereby allowing the rotating stand 2208B to move to the stowed position.", "Referring to FIG.", "25E, while in the inverted configuration the microscope 2200 is supported by the first planar surface 2204A.", "To convert the microscope 2200 from the inverted configuration into the upright configuration, the user first tilts the microscope 2200 toward the second planar surface 2204B.", "Referring to FIG.", "25D, the microscope 2200 is shown in an intermediate position as the microscope 2200 rests on the second planar surface 2204B.", "The user then continues the conversion process by titling the microscope 2200 toward the third planar surface 2204C.", "Referring to FIG.", "25C, the microscope 2200 is shown in an intermediate position as the microscope 2200 rests on the third planar surface 2204C.", "The user then continues the conversion process by titling the microscope 2200 toward the fourth planar surface 2204D.", "Referring to FIG.", "25B, the microscope 2200 is shown in an intermediate position as the microscope 2200 rests on the fourth planar surface 2204D.", "The user then finishes the conversion process by titling the microscope 2200 toward the fifth planar surface 2204E.", "Referring to FIG.", "25A, the microscope 2200 is shown in the upright position as the microscope 2200 rests on the fifth planar surface 2204E.", "The user may then mount the portable display device 2210 to the microscope 2200 by using the first mounting slot 2206A and positioning the first rotating stand 2208A in the deployed configuration.", "The user may further reposition the focus knob 2218 to whichever focus knob receptacle 2217A-D is desired.", "While in this example conversion of the microscope may involve tilting the microscope 2200 up to four instances and using five planar surfaces 2204A-E, it is understood that fewer or more tilting instances and planar surfaces may be used to convert the microscope from the inverted configuration to the upright configuration without departing from the scope of the invention.", "Terminology The foregoing description is provided to enable a person skilled in the art to practice the various configurations described herein.", "While the subject technology has been particularly described with reference to the various figures and configurations, it should be understood that these are for illustration purposes only and should not be taken as limiting the scope of the subject technology.", "There may be many other ways to implement the subject technology.", "Various functions and elements described herein may be partitioned differently from those shown without departing from the scope of the subject technology.", "Various modifications to these configurations will be readily apparent to those skilled in the art, and generic principles defined herein may be applied to other configurations.", "Thus, many changes and modifications may be made to the subject technology, by one having ordinary skill in the art, without departing from the scope of the subject technology.", "It is understood that the specific order or hierarchy of steps in the processes disclosed is an illustration of exemplary approaches.", "Based upon design preferences, it is understood that the specific order or hierarchy of steps in the processes may be rearranged.", "Some of the steps may be performed simultaneously.", "The accompanying method claims present elements of the various steps in a sample order, and are not meant to be limited to the specific order or hierarchy presented.", "A phrase such as an “aspect” does not imply that such aspect is essential to the subject technology or that such aspect applies to all configurations of the subject technology.", "A disclosure relating to an aspect may apply to all configurations, or one or more configurations.", "A phrase such as an aspect may refer to one or more aspects and vice versa.", "A phrase such as an “embodiment” does not imply that such embodiment is essential to the subject technology or that such embodiment applies to all configurations of the subject technology.", "A disclosure relating to an embodiment may apply to all embodiments, or one or more embodiments.", "A phrase such an embodiment may refer to one or more embodiments and vice versa.", "Furthermore, to the extent that the term “include,” “have,” or the like is used in the description or the claims, such term is intended to be inclusive in a manner similar to the term “comprise” as “comprise” is interpreted when employed as a transitional word in a claim.", "The word “exemplary” is used herein to mean “serving as an example, instance, or illustration.” Any embodiment described herein as “exemplary” is not necessarily to be construed as preferred or advantageous over other embodiments.", "A reference to an element in the singular is not intended to mean “one and only one” unless specifically stated, but rather “one or more.” The term “some” refers to one or more.", "All structural and functional equivalents to the elements of the various configurations described throughout this disclosure that are known or later come to be known to those of ordinary skill in the art are expressly incorporated herein by reference and intended to be encompassed by the subject technology.", "Moreover, nothing disclosed herein is intended to be dedicated to the public regardless of whether such disclosure is explicitly recited in the above description." ] ]
Patent_15876004
[ [ "IMAGE CAPTURING APPARATUS, IMAGE CAPTURING SYSTEM, CONTROL METHOD OF IMAGE CAPTURING APPARATUS, AND COMPUTER READABLE STORAGE MEDIUM", "An image capturing apparatus includes: an encoding unit configured to perform encoding processing on an image output from an image capturing unit for obtaining an image; a communication unit configured to receive designation of a resolution of the encoding unit from an information processing apparatus; an obtaining unit configured to obtain a resolution which is associated with the resolution set for the image capturing unit, and is settable for the encoding unit; a determination unit configured to determine whether the designated resolution is the resolution obtained by the obtaining unit and settable for the encoding unit; and a transmission unit configured to transmit an error response to the information processing apparatus, if the determination unit determines that the designated resolution is not the resolution obtained by the obtaining unit and settable for the encoding unit." ], [ "1.An image capturing apparatus comprising: a computer executing instructions that, when executed by the computer, cause the computer to function as: a receiving control unit configured to control a receiving unit which receives, from an external apparatus, a command designating a parameter value related to image data; and a transmitting control unit configured to control a transmitting unit which transmits a response to the external apparatus in response to the command received by the receiving unit, wherein a video source mode is settable to the image capturing apparatus, wherein the video source mode defines at least a maximum value for a parameter of a first kind and a maximum value for a parameter of a second kind, wherein, an error response is not transmitted to the external apparatus from the transmitting unit in a state where a first video source mode is being set to the image capturing apparatus, if the parameter value designated by the command is not settable in the state and the parameter value designated by the command is the parameter value for the parameter of the first kind, and wherein the transmitting control unit is configured to cause the transmitting unit to transmit an error response to the external apparatus in response to the command received by the receiving unit in the state, if the parameter value designated by the command is not settable in the state and the parameter value designated by the command is the parameter value for the parameter of the second kind.", "2.The image capturing apparatus according to claim 1, wherein the video source mode is related to a video source configuration and a video encoder configuration.", "3.The image capturing apparatus according to claim 1, wherein the video source mode includes information defining a plurality of parameters including resolution.", "4.The image capturing apparatus according to claim 3, wherein the transmitting control unit is configured not to cause the transmitting unit to transmit the error response to the external apparatus, if the receiving unit receives a command related to a predetermined parameter among the plurality of parameters from the external apparatus.", "5.The image capturing apparatus according to claim 3, wherein the plurality of parameters further include at least one of a frame rate and an encoding method.", "6.The image capturing apparatus according to claim 1, further comprising a control unit configured to change a setting of the image capturing apparatus from the first video source mode to a second video source mode in which the parameter value designated by the command is settable, if the parameter value designated by the command is not settable in the state and the parameter value designated by the command is the parameter value for the parameter of the first kind.", "7.The image capturing apparatus according to claim 6, wherein a setting of the image capturing apparatus is not changed from the first video source mode to the second video source mode, if the parameter value designated by the command is not settable in the state and the parameter value designated by the command is the parameter value for the parameter of the second kind.", "8.The image capturing apparatus according to claim 1, wherein the parameter of the first kind is a parameter of resolution.", "9.The image capturing apparatus according to claim 8, wherein the resolution is a number of pixels.", "10.The image capturing apparatus according to claim 8, wherein the resolution is indicated by a number of pixels in width and a number of pixels in height.", "11.The image capturing apparatus according to claim 1, wherein the parameter of the first kind is a parameter of a frame rate.", "12.The image capturing apparatus according to claim 1, wherein the parameter of the second kind is a parameter of a frame rate.", "13.The image capturing apparatus according to claim 1, wherein the parameter of the second kind is a parameter of an encoding method.", "14.The image capturing apparatus according to claim 1, further comprising a determination unit configured to determine, based on the video source mode being set to the image capturing apparatus, whether the parameter value designated by the command is settable to the image capturing apparatus.", "15.The image capturing apparatus according to claim 1, wherein the parameter value designated by the command is a parameter value of a video encoder configuration.", "16.The image capturing apparatus according to claim 1, the instructions that, when executed by the computer, cause the computer to further function as an image data generating unit configured to generate image data in accordance with a parameter value based on the command received by the receiving unit, and wherein the transmitting control unit is configured to cause the transmitting unit to transmit the image data generated by the image data generating unit.", "17.The image capturing apparatus according to claim 16, wherein the transmitting control unit is configured to cause the transmitting unit to transmit the image data to the external apparatus via a network.", "18.The image capturing apparatus according to claim 17, wherein the image data generating unit includes a generation unit configured to generate image data based on a video source configuration.", "19.The image capturing apparatus according to claim 17, wherein the image data generating unit includes an encoding unit configured to encode image data based on a video encoder configuration, and wherein the transmitting control unit is configured to cause the transmitting unit to transmit encoded image data.", "20.The image capturing apparatus according to claim 16, wherein the image data generating unit is capable of generating image data by using H.264, in the state where the first video source mode is being set to the image capturing apparatus.", "21.The image capturing apparatus according to claim 16, wherein the image data generating unit is capable of generating image data by using Motion JPEG, in the state where the first video source mode is being set to the image capturing apparatus.", "22.The image capturing apparatus according to claim 16, wherein the image data generating unit is capable of generating image data in which resolution is greater than or equal to 960×540 pixels, in the state where the first video source mode is being set to the image capturing apparatus.", "23.The image capturing apparatus according to claim 16, wherein the image data generating unit is capable of generating image data in which resolution is greater than or equal to 176×144 pixels, in the state where the first video source mode is being set to the image capturing apparatus.", "24.The image capturing apparatus according to claim 16, wherein the image data generating unit is capable of generating image data in which a frame rate is 20 fps, in the state where the first video source mode is being set to the image capturing apparatus.", "25.The image capturing apparatus according to claim 16, wherein the image data generating unit is capable of generating image data in which a frame rate is 30 fps, in the state where the first video source mode is being set to the image capturing apparatus.", "26.The image capturing apparatus according to claim 16, wherein the image data generating unit is capable of generating image data in which resolution is greater than or equal to 960×540 pixels by using H.264, in the state where the first video source mode is being set to the image capturing apparatus.", "27.The image capturing apparatus according to claim 16, wherein the image data generating unit is capable of generating image data in which resolution is greater than or equal to 960×540 pixels and a frame rate is 20 fps by using H.264, in the state where the first video source mode is being set to the image capturing apparatus.", "28.The image capturing apparatus according to claim 16, wherein the image data generating unit is capable of generating image data in which resolution is greater than or equal to 960×540 pixels and a frame rate is 30 fps by using H.264, in the state where the first video source mode is being set to the image capturing apparatus.", "29.A method for an image capturing apparatus which comprises a computer executing instructions that, when executed by the computer, cause the computer to perform the method, the method comprising: a receiving step of receiving, from an external apparatus, a command designating a parameter value related to image data; and a transmitting step of transmitting a response to the external apparatus in response to the command received in the receiving step, wherein a video source mode is settable to the image capturing apparatus, wherein the video source mode defines at least a maximum value for a parameter of a first kind and a maximum value for a parameter of a second kind, wherein, an error response is not transmitted to the external apparatus in the transmitting step in a state where a first video source mode is being set to the image capturing apparatus, if the parameter value designated by the command is not settable in the state and the parameter value designated by the command is the parameter value for the parameter value of the first kind, and wherein, in the transmitting step, an error response is transmitted to the external apparatus in response to the command received in the receiving step in the state, if the parameter value designated by the command is not settable in the state and the parameter value designated by the command is the parameter value for the parameter for the second kind.", "30.An image capturing system comprising: an image capturing apparatus configured to transmit image data to an image receiving apparatus, wherein the image receiving apparatus is configured to receive the image data from the image capturing apparatus, wherein the image capturing apparatus comprises a computer executing instructions that, when executed by the computer, cause the computer to function as: a receiving control unit configured to control a receiving unit which receives a command designating a parameter value related to the image data; an image data generating unit configured to generate the image data in accordance with a parameter value based on the command received by the receiving unit; and a transmitting control unit configured to control a transmitting unit which transmits the image data generated by the image data generating unit, wherein, a video source mode is settable to the image capturing apparatus, wherein, the video source mode defines at least a maximum value for a parameter of a first kind and a maximum value for a parameter of a second kind, wherein, an error response is not transmitted from the transmitting unit in a state where a first video source mode is being set to the image capturing apparatus, if the parameter value designated by the command is not settable in the state and the parameter value designated by the command is the parameter value for the parameter of the first kind, wherein, the transmitting control unit is configured to cause the transmitting unit to transmit an error response in response to the command received by the receiving unit in the state, if the parameter value designated by the command is not settable in the state and the parameter value designated by the command is the parameter value for the parameter of the second kind, wherein the image receiving apparatus comprises: a display control unit configured to display a setting screen to a display unit, the setting screen being for designating the parameter value for the parameter of the first kind and the parameter value for the parameter of the second kind; and a transmitting control unit configured to control a transmitting which transmits a command designating a parameter value designated on the setting screen to the image capturing apparatus.", "31.The image capturing system according to claim 30, wherein the receiving control unit to cause the receiving unit of the image capturing apparatus to receive the command designating the parameter value from the image receiving apparatus, and wherein, the transmitting control unit to cause the transmitting unit of the image capturing apparatus to transmit the error response to the image receiving apparatus in response to the command received by the receiving unit.", "32.The image capturing system according to claim 30, wherein a parameter value for a parameter of at least one kind is capable of being designated from a drop down list displayed on the setting screen.", "33.The image capturing system according to claim 30, wherein the parameter value for the parameter of the first kind and the parameter value for the parameter of the second kind are capable of being designated on the same setting screen displayed by display control unit.", "34.The image capturing system according to claim 30, wherein the parameter of the first kind is a parameter of resolution.", "35.The image capturing system according to claim 30, wherein the parameter of the second kind is at least one of a parameter of an encoding method and a parameter of a frame rate.", "36.The image capturing system according to claim 30, wherein the parameter of the first kind is a parameter of a frame rate.", "37.The image capturing system according to claim 30, wherein the parameter value designated by the command is a parameter value of a video encoder configuration.", "38.A method for an image capturing system, wherein the image capturing system comprises an image capturing apparatus configured to transmit image data to an image receiving apparatus, wherein the image receiving apparatus is configured to receive the image data from the image capturing apparatus, wherein the method for the image capturing system comprises: a method for the image capturing apparatus which comprises a computer executing instructions that, when executed by the computer, cause the computer to perform the method for the image capturing apparatus, the method for the image capturing apparatus comprising: a receiving step of receiving a command designating a parameter value related to the image data; an image data generating step of generating the image data in accordance with a parameter value based on the command received in the receiving step; and a transmitting step of transmitting the image data generated in the image data generating step, wherein, a video source mode is settable to the image capturing apparatus, wherein, the video source mode defines at least a maximum value for a parameter of a first kind and a maximum value for a parameter of a second kind, wherein, an error response is not transmitted in the transmitting step in a state where a first video source mode is being set to the image capturing apparatus, if the parameter value designated by the command is not settable in the state and the parameter value designated by the command is the parameter value for the parameter of the first kind, wherein, in the transmitting step, an error response is transmitted in response to the command received in the receiving step in the state, if the parameter value designated by the command is not settable in the state and the parameter value designated by the command is the parameter value for the parameter of the second kind, and a method for the image receiving apparatus which comprises a computer executing instructions that, when executed by the computer, cause the computer to perform the method for the image receiving apparatus, the method for the image receiving apparatus comprising: a display control step of displaying a setting screen to a display unit, the setting screen being for designating the parameter value for the parameter of the first kind and the parameter value for the parameter of the second kind; and a transmitting step of transmitting a command designating a parameter value designated on the setting screen to the image capturing apparatus." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY OF INVENTION <EOH>The present invention provides an image capturing technique that prevents the occurrence of mismatching in a combination of the resolution of image data to be generated by an image capturing unit and the resolution of a distribution image to be generated by a compression encoding unit, even when only one resolution is changed.", "According to one aspect of the present invention, there is provided an image capturing apparatus comprising: an encoding unit configured to perform encoding processing on an image output from an image capturing unit for obtaining an image; a communication unit configured to receive designation of a resolution of the encoding unit from an information processing apparatus; an obtaining unit configured to obtain a resolution which is associated with the resolution set for the image capturing unit, and is settable for the encoding unit; a determination unit configured to determine whether the designated resolution is the resolution obtained by the obtaining unit and settable for the encoding unit; and a transmission unit configured to transmit an error response to the information processing apparatus via the communication unit, if the determination unit determines that the designated resolution is not the resolution obtained by the obtaining unit and settable for the encoding unit.", "According to another aspect of the present invention, there is provided a control method of an image capturing apparatus including an encoding unit configured to perform encoding processing on an image output from an image capturing unit for obtaining an image, comprising: a first communication step of receiving designation of a resolution of the encoding unit from an information processing apparatus; an obtaining step of obtaining a resolution which is associated with the resolution set for the image capturing unit, and is settable for the encoding unit; a determination step of determining whether the designated resolution is the resolution obtained in the obtaining step and settable for the encoding unit; and a transmission step of transmitting an error response to the information processing apparatus, if it is determined in the determination step that the designated resolution is not the resolution obtained in the obtaining step and settable for the encoding unit.", "According to still another aspect of the present invention, there is provided a computer readable storage medium containing computer-executable instructions that control an image capturing apparatus including an encoding unit configured to perform encoding processing on an image output from an image capturing unit for obtaining an image, the medium comprising: computer-executable instructions that receive designation of a resolution of the encoding unit from an information processing apparatus; computer-executable instructions that obtain a resolution which is associated with the resolution set for the image capturing unit, and is settable for the encoding unit; computer-executable instructions that determine whether the designated resolution is the obtained resolution settable for the encoding unit; and computer-executable instructions that transmit an error response to the information processing apparatus, if it is determined that the designated resolution is not the obtained resolution settable for the encoding unit.", "According to yet another aspect of the present invention, there is provided an image capturing system comprising an image capturing apparatus including an encoding unit configured to encode an image output from an image capturing unit for obtaining an image, and an information processing apparatus connected to the image capturing apparatus across a network, wherein the information processing apparatus comprises a generation unit configured to generate designation of a resolution of the encoding unit, and the image capturing apparatus comprises: a communication unit configured to receive the designation of the resolution of the encoding unit from the information processing apparatus; an obtaining unit configured to obtain a resolution which is associated with the resolution set for the image capturing unit, and is settable for the encoding unit; a determination unit configured to determine whether the designated resolution is the resolution obtained by the obtaining unit and settable for the encoding unit; and a transmission unit configured to transmit an error response to the information processing apparatus via the communication unit, if the determination unit determines that the designated resolution is not the resolution obtained by the obtaining unit and settable for the encoding unit.", "Further features of the present invention will become apparent from the following description of exemplary embodiments (with reference to the attached drawings)." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a Continuation of U.S. application Ser.", "No.", "15/432,759, filed Feb. 14, 2017, which is a Continuation of U.S. application Ser.", "No.", "14/646,330, filed May.", "20, 2015, now U.S. Pat.", "No.", "9,609,198 B2, which is a National Stage filing of International Application No.", "PCT/JP2013/081331 filed Nov. 14, 2013, which claims the benefit of priority from Japanese Patent Application No.", "2012-256772 filed Nov. 22, 2012, the disclosures of each of which are hereby incorporated by reference herein in their entirety.", "BACKGROUND Technical Field The present invention relates to an image capturing apparatus, an image capturing system, a control method of the image capturing apparatus, and a computer readable storage medium.", "Background Art Conventionally, an image capturing apparatus for transmitting a captured image to a receiving apparatus includes commands for allowing an external apparatus to change the settings of the image capturing apparatus and designate the start of image distribution.", "Known examples of these commands are those defined by standards formulated by the ONVIF (Open Network Video Interface Forum).", "In the ONVIF specifications (http://www.onvif.org/specs/DocMap.html), commands formulated by the ONVIF are described.", "The above-described commands include, for example, a command for changing, from an external apparatus, the resolution of image data to be generated by an image capturing unit of the image capturing apparatus.", "The above-described commands also include a command for changing the resolution of a distribution image to be distributed to an external apparatus when the distribution image is generated by encoding image data generated by the image capturing unit.", "For example, in the ONVIF standards, a SetVideoSourceMode command is defined as the former command, and a SetVideoEncoderConfiguration command is defined as the latter command.", "Furthermore, in addition to the ONVIF standards, Japanese Patent Laid-Open No.", "2005-323007 has disclosed an image capturing apparatus including a control unit for controlling the expansion and compression of a captured image.", "Unfortunately, there is a problem that if only one of the resolution of image data to be generated by the image capturing unit and the resolution of a distribution image to be generated by a compression encoding unit is changed, mismatching occurs in a combination of the two resolutions and this makes the generation of the distribution image impossible in some cases.", "Also, in a case like this, it is necessary to transmit a command for correctly changing the other resolution from an external apparatus to the image capturing apparatus, in order to cancel the mismatching and correctly generate the distribution image.", "This complicates the user's operation.", "Assume that the output resolution of the image capturing unit is 1,600×1,200 pixels (UXGA), and the output resolution of the compression encoding unit is 1,280×1,024 pixels (SXGA).", "In this case, if the output resolution of the image capturing unit is changed to 1,024×768 (XGA), the compression encoding unit in which a higher output resolution is set may become unable to generate any distribution image.", "Assume also that the output resolution of the image capturing unit is 1,600×1,200 pixels (resolution aspect ratio=4:3), and the output resolution of the compression encoding unit is 1,280×1,024 pixels (resolution aspect ratio=4:3).", "In this case, if the output resolution of the image capturing unit is changed to 1,920×1,080 (full HD, resolution aspect ratio=16:9), the compression encoding unit in which a different resolution aspect ratio is set may become unable to generate any distribution image.", "If this is the case, before obtaining a video stream from the image capturing unit, the user must change the output resolution of the compression encoding unit to a resolution, such as 1,024×768 (XGA) or 1,920×1,080 (resolution aspect ratio=16:9) , which matches the output resolution of the image capturing unit, and this complicates the operation.", "SUMMARY OF INVENTION The present invention provides an image capturing technique that prevents the occurrence of mismatching in a combination of the resolution of image data to be generated by an image capturing unit and the resolution of a distribution image to be generated by a compression encoding unit, even when only one resolution is changed.", "According to one aspect of the present invention, there is provided an image capturing apparatus comprising: an encoding unit configured to perform encoding processing on an image output from an image capturing unit for obtaining an image; a communication unit configured to receive designation of a resolution of the encoding unit from an information processing apparatus; an obtaining unit configured to obtain a resolution which is associated with the resolution set for the image capturing unit, and is settable for the encoding unit; a determination unit configured to determine whether the designated resolution is the resolution obtained by the obtaining unit and settable for the encoding unit; and a transmission unit configured to transmit an error response to the information processing apparatus via the communication unit, if the determination unit determines that the designated resolution is not the resolution obtained by the obtaining unit and settable for the encoding unit.", "According to another aspect of the present invention, there is provided a control method of an image capturing apparatus including an encoding unit configured to perform encoding processing on an image output from an image capturing unit for obtaining an image, comprising: a first communication step of receiving designation of a resolution of the encoding unit from an information processing apparatus; an obtaining step of obtaining a resolution which is associated with the resolution set for the image capturing unit, and is settable for the encoding unit; a determination step of determining whether the designated resolution is the resolution obtained in the obtaining step and settable for the encoding unit; and a transmission step of transmitting an error response to the information processing apparatus, if it is determined in the determination step that the designated resolution is not the resolution obtained in the obtaining step and settable for the encoding unit.", "According to still another aspect of the present invention, there is provided a computer readable storage medium containing computer-executable instructions that control an image capturing apparatus including an encoding unit configured to perform encoding processing on an image output from an image capturing unit for obtaining an image, the medium comprising: computer-executable instructions that receive designation of a resolution of the encoding unit from an information processing apparatus; computer-executable instructions that obtain a resolution which is associated with the resolution set for the image capturing unit, and is settable for the encoding unit; computer-executable instructions that determine whether the designated resolution is the obtained resolution settable for the encoding unit; and computer-executable instructions that transmit an error response to the information processing apparatus, if it is determined that the designated resolution is not the obtained resolution settable for the encoding unit.", "According to yet another aspect of the present invention, there is provided an image capturing system comprising an image capturing apparatus including an encoding unit configured to encode an image output from an image capturing unit for obtaining an image, and an information processing apparatus connected to the image capturing apparatus across a network, wherein the information processing apparatus comprises a generation unit configured to generate designation of a resolution of the encoding unit, and the image capturing apparatus comprises: a communication unit configured to receive the designation of the resolution of the encoding unit from the information processing apparatus; an obtaining unit configured to obtain a resolution which is associated with the resolution set for the image capturing unit, and is settable for the encoding unit; a determination unit configured to determine whether the designated resolution is the resolution obtained by the obtaining unit and settable for the encoding unit; and a transmission unit configured to transmit an error response to the information processing apparatus via the communication unit, if the determination unit determines that the designated resolution is not the resolution obtained by the obtaining unit and settable for the encoding unit.", "Further features of the present invention will become apparent from the following description of exemplary embodiments (with reference to the attached drawings).", "BRIEF DESCRIPTION OF DRAWINGS FIGS.", "1A and 1B are views showing examples of the arrangements of an image capturing apparatus and image capturing system; FIG.", "2 is a view showing an example of the internal arrangement of the image capturing apparatus; FIG.", "3 is a view showing an example of the structure of parameters held by the image capturing apparatus; FIG.", "4 is a view showing an example of a table storing information for matching the settings of an image capturing unit of the image capturing apparatus with the settings of a compression encoding unit; FIG.", "5A is a view showing an example of a command sequence from the start of setting of the image capturing apparatus to video distribution; FIG.", "5B is a view showing an example of a command sequence when changing the output resolution of the image capturing unit of the image capturing apparatus; FIG.", "5C is a view showing an example of a command sequence when changing the output resolution of the compression encoding unit of the image capturing apparatus; FIG.", "6A is a view for explaining a procedure when the image capturing apparatus changes the settings of the image capturing unit; FIG.", "6B is a view for explaining a procedure when the image capturing apparatus transmits a selectable set value to an information processing apparatus; FIG.", "6C is a view for explaining a procedure when the image capturing apparatus changes the settings of the compression encoding unit; FIG.", "6D is a view for explaining a procedure when the image capturing apparatus transmits a selectable set value to the information processing apparatus; FIG.", "6E is a view for explaining a procedure when the image capturing apparatus changes the settings of the compression encoding unit; FIG.", "7A is a view showing an example of a setting screen of a client apparatus; and FIG.", "7B is a view showing another example of the setting screen of the client apparatus.", "DESCRIPTION OF EMBODIMENTS Exemplary embodiments of the present invention will be explained in detail below with reference to the accompanying drawings.", "However, constituent elements described in these embodiments are merely examples, and the technical scope of the present invention is determined by the scope of the appended claims, and is not limited by the following individual embodiments.", "First Embodiment FIG.", "1A is a view showing an example of a monitoring camera 1000 as an image capturing apparatus according to the embodiment of the present invention.", "A mechanism 1101 is a mechanism for changing the direction of a lens in a panning direction, a mechanism 1102 is a mechanism for changing the lens direction in a tilting direction, and a mechanism 1103 is a mechanism for changing zooming.", "FIG.", "1B is a view showing an example of the configuration of an image capturing system including the monitoring camera 1000.A client apparatus 2000 (an information processing apparatus) as an external apparatus is connected to the monitoring camera 1000 across a network 1500 so as to be able to communicate with the monitoring camera 1000.The client apparatus 2000 transmits various commands such as a command for changing image capturing parameters (to be described later), a command for driving a platform, and a command for starting video streaming to the monitoring camera 1000.The monitoring camera 1000 transmits responses to these commands and video streaming to the client apparatus 2000.FIG.", "2 is a view showing an example of the internal arrangement of the monitoring camera 1000 (the image capturing apparatus).", "Referring to FIG.", "2, a control unit 1001 is a CPU or the like, and controls the whole monitoring camera 1000.A storage unit 1002 is used as various data storage areas such as a storage area for programs to be mainly executed by the control unit 1001, a work area to be used while the programs are executed, and a storage area for image data generated by an image capturing unit 1003 (to be described below).", "The image capturing unit 1003 converts an analog signal obtained by capturing an object image into digital data, and outputs the data as a captured image (image data) to the storage unit 1002.The resolution and frame rate of the image data output from the image capturing unit 1003 can be changed by a SetVideoSourceMode command (to be described later).", "A compression encoding unit 1004 generates image data by performing compression encoding processing on the captured image output from the image capturing 1003 based on a format such as Motion JPEG or H.264, and outputs the generated image data to the storage unit 1002.The types of the resolution (distribution resolution) of the image data output from the compression encoding unit 1004 have a dependency relationship as shown in FIG.", "4 (to be described later) with each mode of the image capturing unit 1003.A communication unit 1005 receives each control command from the external apparatus (client apparatus 2000).", "Also, the communication unit 1005 transmits a response to each control command to the external apparatus (client apparatus 2000).", "Furthermore, the communication unit 1005 receives first designation for setting the resolution of the image capturing unit 1003, or second designation for setting the resolution of the compression encoding unit 1004.When the setting of one resolution is to be changed to a different resolution setting by the first or second designation, the control unit 1001 changes the setting of the other resolution to a resolution matching the setting of one resolution.", "This resolution changing process will be explained in detail later with reference to FIGS.", "6A, 6C, and 6E.", "An image capturing control unit 1006 controls the tilting mechanism 1101, panning mechanism 1102, and zooming mechanism 1103 in response to the values of a panning angle, tilting angle, and zooming magnification input from the control unit 1001.Also, the image capturing control unit 1006 provides the current panning angle value, tilting angle value, and zooming magnification value of the monitoring camera 1000, in accordance with an inquiry from the control unit 1001.The internal arrangement of the monitoring camera 1000 has been explained above with reference to FIG.", "2.However, the processing blocks shown in FIG.", "2 are exemplary blocks, so the arrangement of the image capturing apparatus according to the embodiment of the present invention is not limited to the processing blocks shown in FIG.", "2.For example, it is also possible to use a voice input unit in addition to the processing blocks shown in FIG.", "2, or exclude the image capturing control unit therefrom, that is, various modifications and changes can be made.", "Next, the names and contents of commands, parameters, and the like used in this embodiment will be explained.", "FIG.", "3 shows the structure of parameters held by the monitoring camera 1000 (the image capturing apparatus) in this embodiment.", "A MediaProfile 6100 is a parameter set for storing various setting items of the monitoring camera by associating them with each other.", "The MediaProfile 6100 holds links to various setting items including a ProfileToken as the ID (identification information) of the MediaProfile 6100, a VideoSourceConfiguration 6102, a VideoEncoderConfiguration 6103, a PTZConfiguration 6104, and a voice encoder.", "A VideoSource 6101 is a set of parameters indicating the performance of the image capturing unit 1003 of the monitoring camera.", "The VideoSource 6101 includes a VideoSourceToken as the ID of the VideoSource 6101, and Resolution indicating the resolution of image data which the image capturing unit 1003 can output.", "The VideoSource 6101 can switch to a plurality of other VideoSourceModes (operation modes) that support different Resolutions, in accordance with a SetVideoSourceMode command (to be described later).", "The VideoSourceConfiguration 6102 is a set of parameters for associating the VideoSource 6101 of the monitoring camera 1000 with the MediaProfile 6100.The VideoSourceConfiguration 6102 includes Bounds that designate a portion to be cut out, as a distribution image, from image data output from the VideoSource 6101.The VideoEncoderConfiguration 6103 is a set of parameters for associating the settings of an encoder (the compression encoding unit 1004) pertaining to image data compression encoding with the MediaProfile 6100.The compression encoding unit 1004 of the monitoring camera 1000 compression-encodes image data output based on the contents of the VideoSource 6101 and VideoSourceConfiguration 6102.The compression encoding unit 1004 of the monitoring camera 1000 compression-encodes image data output from the image capturing unit 1003, in accordance with a parameter such as the compression encoding scheme (for example, JPEG or H.264) set in VideoEncoderConfiguration 6103, the frame rate, or resolution.", "The monitoring camera 1000 distributes the compression-encoded image data to the client apparatus 2000 via the communication unit 1005.The VideoEncoderConfiguration 6103 includes a VideoEncoderConfigurationToken as the ID (identification information) of the VideoEncoderConfiguration 6103.The VideoEncoderConfiguration 6103 also includes Encoding for designating a compression encoding scheme, a Resolution for designating the resolution of an output image, and a Quality for designating the compression encoding quality.", "Furthermore, the VideoEncoderConfiguration 6103 includes FramerateLimit for designating the maximum frame rate of an output image, and BitrateLimit for designating the maximum bit rate.", "The PTZConfiguration 6104 is a set of parameters for associating the settings of the panning mechanism 1101, tilting mechanism 1102, and zooming mechanism 1103 of the monitoring camera 1000 with the MediaProfile 6100.The PTZConfiguration 6104 contains information pertaining to a coordinate system for expressing actual panning/tilting angle values and an actual zooming magnification value in the panning mechanism, tilting mechanism, and zooming mechanism.", "A table shown in FIG.", "4 contains information of a plurality of choices for matching the settings of the image capturing unit 1003 with those of the compression encoding unit 1004.This table shown in FIG.", "4 indicates the setting contents of VideoSourceModes supported by the monitoring camera 1000, and the setting contents of the VideoEncoderConfigurations 6103 matching the VideoSourceModes.", "The table shown in FIG.", "4 is prestored in the storage unit 1002 of the monitoring camera 1000, and referred to by the control unit 1001 any time.", "The table shown in FIG.", "4 need not always be prestored in the storage unit 1002, and may also obtain necessary data by referring to a database of the external apparatus via the communication unit 1005.A VideoSourceMode 4000 indicates the management number of a VideoSourceMode to be used in internal processing by the monitoring camera 1000.In this embodiment, the monitoring camera 1000 supports three VideoSourceModes S1, S2, and S3.A Resolution 4001 is the parameter value of the Resolution of each VideoSourceMode (S1, S2, or S3), and indicates the resolution of image data generated by the image capturing unit 1003.A Framerate 4002 is the parameter value of the frame rate of each VideoSourceMode, and indicates the frame rate of image data to be generated by the image capturing unit 1003.Items from Encoding 4003 to FramerateLimit 4006 are choices of the parameters of the VideoEncoderConfiguration 6103 which match when the VideoSource 6101 is each VideoSourceMode.", "The Encoding 4003 indicates a choice of a compression encoding scheme in the VideoEncoderConfiguration, which matches the VideoSourceMode.", "The Resolution Choice 4004 indicates the management number of the resolution of the compression-encoded output image in the VideoEncoderConfiguration, which is to be used in the internal processing of the monitoring camera 1000.In this embodiment, the monitoring camera 1000 supports four resolutions E1 to E4.The Resolution 4005 is the parameter value of the resolution of the VideoEncoderConfiguration, which matches each VideoSourceMode.", "This set value determines the resolution of a distribution image to be output from the compression encoding unit 1004.The FramerateLimit 4006 (the frame rate limit) indicates the maximum value of the frame rate in the VideoEncoderConfiguration, which matches each VideoSourceMode.", "FIG.", "5A shows a command sequence from setting start to video distribution between the monitoring camera 1000 and client apparatus 2000.Transaction means a pair of a command to be transmitted from the client apparatus 2000 to the monitoring camera 1000, and a response to be returned from the monitoring camera 1000 to the client apparatus 2000.A transaction 7100 is the transaction of a GetVideoSourceConfigurations command.", "By this command, the client apparatus 2000 obtains a list of the VideoSourceConfigurations 6102 held by the monitoring camera 1000.A transaction 7101 is the transaction of a GetVideoEncoderConfigurations command.", "By this command, the client apparatus 2000 obtains a list of the VideoEncoderConfigurations 6103 held by the monitoring camera 1000.A transaction 7102 is the transaction of a GetConfigurations command.", "By this command, the client apparatus 2000 obtains a list of the PTZConfigurations 6104 held by the monitoring camera 1000.A transaction 7103 is the transaction of a CreateProfile command.", "By this command, the client apparatus 2000 causes the monitoring camera 1000 to form a new MediaProfile 6100, and obtains its Profiletoken.", "A transaction 7104 is the transaction of an AddVideoSourceConfiguration command, and a transaction 7105 is the transaction of an AddVideoEncoderConfiguration command.", "A transaction 7108 is each transaction of an AddPTZConfiguration command.", "By designating the ID in these commands, the client apparatus 2000 can associate a desired VideoSourceConfiguration, desired VideoEncoderConfiguration, and desired PTZConfiguration with the designated MediaProfile.", "A transaction 7106 is the transaction of a GetVideoEncoderConfigurationOptions command.", "By this command, the client apparatus 2000 obtains the choices or set value range of each parameter acceptable by the monitoring camera 1000, in the VideoEncoderConfiguration designated by the ID.", "A transaction 7107 is the transaction of a SetVideoEncoderConfiguration command.", "By this command, the client apparatus 2000 sets each parameter of the VideoEncoderConfiguration 6103.A transaction 7109 is the transaction of a GetStreamUri command.", "By this command, the client apparatus 2000 obtains an address (URI) with which the monitoring camera 1000 obtains a distribution stream based on the settings of the designated MediaProfile.", "A transaction 7110 is the transaction of a Describe command.", "By executing this command by using the URI obtained in the transaction 7109, the client apparatus 2000 requests and obtains information of contents to be distributed by a stream by the monitoring camera 1000.A transaction 7111 is the transaction of a Setup command.", "By executing this command by using the URI obtained in the transaction 7109, the client apparatus 2000 and monitoring camera 1000 share a stream transmission method including the session number.", "A transaction 7112 is the transaction of a Play command.", "By executing this command by using the session number obtained in the transaction 7111, the client apparatus 2000 requests the monitoring camera 1000 to start streaming.", "In a distribution stream 7113, the monitoring camera 1000 distributes a stream requested to be started in the transaction 7112 by the transmission method shared in the transaction 7111.A transaction 7114 is the transaction of a Teardown command.", "By executing this command by using the session number obtained in the transaction 7111, the client apparatus 2000 requests the monitoring camera 1000 to stop the stream.", "FIG.", "5B shows a command sequence when the setting change of the image capturing unit 1003, which includes changing of the output resolution, is performed between the monitoring camera 1000 and client apparatus 2000.A transaction 7200 is the transaction of a GetVideoSourceMode command.", "The GetVideoSourceMode command is a command for returning a list of VideoSourceModes supported by the VideoSource 6101 having the ID designated by the client apparatus 2000.When receiving the GetVideoSourceMode command, the control unit 1001 of the monitoring camera 1000 obtains the parameters of the VideoSourceModes S1 to S3 saved in the storage unit 1002 and shown in FIG.", "4, and returns the parameters to the client apparatus 2000 via the communication unit 1005.A transaction 7201 is the transaction of a SetVideoSourceMode command.", "The SetVideoSourceMode command is a command for designating changing of the VideoSourceMode of the VideoSource 6101 designated by the client apparatus 2000.Transactions 7109 to 7112 and a distribution stream 7113 are the same as those shown in FIG.", "5A.", "FIG.", "5C shows a typical command sequence when changing the output resolution of the compression encoding unit 1004 between the monitoring camera 1000 and client apparatus 2000.Transactions 7101, 7106, 7107, and 7109 to 7113 are the same as those of the command sequence shown in FIG.", "5A.", "FIG.", "6A is a view showing processing when the monitoring camera 1000 has received the above-described SetVideoSourceMode command (transaction 7201) from the client apparatus 2000.In step S1000, the control unit 1001 stops a video stream currently being distributed via the communication unit 1005.In step S1001, the control unit 1001 determines whether the input VideoSourceMode is S1, S2, or S3, obtains the set value of the corresponding VideoSourceMode, and sets the set value in the image capturing unit 1003.In step S1002, the control unit 1001 determines whether the set value of the resolution (Resolution) of each VideoEncoderConfiguration stored in the storage unit 1002 is E1, E2, E3, or E4.The control unit 1001 sets, in the VideoEncoderConfiguration, the resolution matching the VideoSourceMode determined in step S1001 and having the same management number.", "That is, if the resolution of the VideoEncoderConfiguration is 1,920×1,080=E2 before command reception when the VideoSourceMode of the VideoSource 6101 is changed from S1 to S2, the resolution is changed to 2,048×1,536 as the resolution of E2 matching S2 by the reception of this command.", "In step S1003, the control unit 1001 sets an Enable flag corresponding to the VideoSourceMode determined in step S1001 to “True”, and sets enable flags corresponding to other VideoSourceModes to “False”.", "In step S1004, the control unit 1001 transmits a normal response to the client apparatus 2000.FIG.", "6B shows processing when the monitoring camera 1000 has received a GetVideoEncoderConfigurationOption command (the transaction 7106) from the client apparatus 2000.In step S1100, the control unit 1001 obtains the set value of the VideoSourceMode currently set in the VideoSource 6101, and determines whether the set value is S1, S2, or S3.In steps S1101, S1102, and S1103, the control unit 1001 refers to the table shown in FIG.", "4 which is stored in the storage unit 1002, and obtains a selectable set value (choice) matching the current VideoSourceMode.", "The control unit 1001 obtains the choices E1 to E4 of the resolution of the VideoEncoderConfiguration, the choices of the Encoding, and the FramerateLimit as the maximum frame rate.", "For example, when the set value of the current VideoSourceMode is S3, the control unit 1001 obtains 800×600 (E1) , 640×480 (E2) , 320×240 (E3), and 176×144 (E4) as the choices of the Resolution.", "Also, the control unit 1001 obtains H.264 and MotionJPEG as the choices of the Encoding, and 30 fps as the FramerateLimit.", "In step S1104, the control unit 1001 obtains the choices and setting range of the VideoEncoderConfiguration independent of the current VideoSourceMode from the storage unit 1002.For example, the control unit 1001 obtains 1 to 5 as the settable range of the Quality, and 60 Mbps as the set value of the BitrateLimit.", "In step S1105, the control unit 1001 transmits a normal response containing the choices and setting ranges obtained in steps S1101 to S1104 to the client apparatus 2000 via the communication unit 1005.FIG.", "6C shows processing when the monitoring camera 1000 has received the above-described SetVideoEncoderConfiguration command (transaction 7107) from the client apparatus 2000.Insteps S1200, S1201, and S1202, the control unit 1001 determines whether the set value input to the received SetVideoEncoderConfiguration matches the current VideoSourceMode.", "The control unit 1001 refers to the table shown in FIG.", "4 which is stored in the storage unit 1002, and determines whether the Resolution, Encoding, and FramerateLimit input to the received SetVideoEncoderConfiguration match the current VideoSourceMode.", "If even one parameter does not match, the control unit 1001 advances the process to step S1210.In step S1210, the control unit 1001 transmits an error response to the client apparatus 2000 via the communication unit 1005.On the other hand, in step S1203, the control unit 1001 stores the set values of the VideoEncoderConfiguration including the Quality, BitrateLimit, Encoding, FramerateLimit, and Resolution in the storage unit 1002, and sets them in the compression encoding unit 1004.In step S1204, the control unit 1001 transmits a normal response to the client apparatus 2000.FIG.", "7A is a view showing an example of a setting screen of the client apparatus 2000, in which the VideoSourceMode and VideoEncoderConfiguration of the monitoring camera 1000 according to this embodiment are set.", "When the setting screen shown in FIG.", "7A is opened, the client apparatus 2000 executes the sequence shown in FIG.", "5A, and displays a video stream obtained in the transaction 7113 in a LiveView area 9000 (a display area).", "An area 9001 is a VideoSourceMode selection area.", "The client apparatus 2000 displays, in this area, a list of VideoSourceModes obtained by the transaction 7200 of the GetVideoSourceMode command executed when this setting screen is opened, so that the user can select a mode as indicated by reference numeral 9002.If a VideoSourceMode different from the current setting is selected in this area, the client apparatus 2000 executes the SetVideoSourceMode command, and changes the VideoSourceMode of the monitoring camera 1000.In this state, the client apparatus 2000 executes the transactions shown in FIG.", "5B, and displays a video stream having the new settings in the LiveView area 9000 (the display area).", "In addition, the client apparatus 2000 executes the GetVideoEncoderConfigurationOptions command, and updates the choices and setting ranges of the individual parameters of the VideoEncoder in this screen by using the obtained results.", "Accordingly, the client apparatus 2000 can always provide the user with the choices and setting ranges of the set values of the VideoEncoderConfiguration matching the VideoSourceMode.", "Setting screen switching sections 9003 and 9004 are tabs for switching VideoEncoder setting screens for allowing the user to change the set values of the VideoEncoderConfiguration 6103 of the monitoring camera 1000.The number of tabs is two (the setting screen switching sections 9003 and 9004) in this embodiment, but it is also possible to display tabs equal in number to the VideoEncoderConfigurations 6103 obtained by the GetVideoEncoderConfigurations command and supported by the monitoring camera 1000.An area 9005 is an area for allowing the user to select the compression encoding scheme of each VideoEncoderConfiguration.", "The GetVideoEncoderConfigurationOptions command is executed when the setting screen is opened, or when a new VideoSourceMode is selected in the VideoSourceMode selection area.", "The area 9005 displays the choices of encoding obtained by the GetVideoEncoderConfigurationOptions command.", "A choice 9006 indicates currently selectable Encoding, and a choice 9007 indicates currently unselectable Encoding.", "An area 9008 is a Detail area for allowing the user to select the FramerateLimit, BitrateLimit, and Quality included in the VideoEncoderConfiguration 6103.The GetVideoEncoderConfigurationOptions command is executed when the setting screen shown in FIG.", "7A is opened, or when a new VideoSourceMode is selected in the VideoSourceMode selection area.", "The contents of the setting ranges obtained by the GetVideoEncoderConfigurationOptions command are reflected in setting ranges 9009, 9010, and 9011.An area 9012 is an area for selecting the resolution of the VideoEncoderConfiguration 6103.The GetVideoEncoderConfigurationOptions command is executed when the setting screen shown in FIG.", "7A is opened, or when a new VideoSourceMode is selected in the VideoSourceMode selection area.", "The contents of the choices of the Resolution parameter obtained by the GetVideoEncoderConfigurationOptions command are displayed in a dropdown list 9013.When the user presses an apply button 9014, the client apparatus 2000 transmits the SetVideoEncoderConfiguration command to the monitoring camera 1000.The parameters selected in the areas 9005, 9008, and 9012 are reflected in the compression encoding unit 1004 of the monitoring camera 1000.When the VideoSourceMode is changed by the client apparatus 2000, the monitoring camera 1000 can maintain the contents of choices provided by the setting contents of the VideoEncoderConfiguration and by the VideoEncoderConfigurationOptions command, as contents matching the VideoSourceMode.", "Accordingly, when obtaining a distribution image after changing the VideoSourceMode, the client apparatus 2000 need not change the setting contents of the VideoEncoderConfiguration to contents matching the VideoSourceMode.", "That is, even when the resolution of image data to be generated by the image capturing unit 1003 of the monitoring camera 1000 is changed, it is possible to prevent the occurrence of mismatching in various settings including the resolution of a distribution image to be generated by the compression encoding unit 1004.It is also possible to easily generate a distribution image after the resolution is changed.", "Second Embodiment In the first embodiment, the arrangement in which the contents of choices provided by the setting contents of the VideoEncoderConfiguration and by the VideoEncoderConfigurationOptions command are changed to contents matching the VideoSourceMode has been explained.", "In this arrangement of the first embodiment, the types of the choices of the resolution of the compression encoding unit provided by the GetVideoEncoderConfigurationOptions command are not limited to those matching the VideoSourceMode.", "It is also possible to always provide all choices of the resolution to the client apparatus 2000 by the GetVideoEncoderConfigurationOptions command.", "In accordance with a new set value set in the compression encoding unit 1004 by the client apparatus 2000 by using the SetVideoEncoderConfiguration command, the monitoring camera 1000 may also internally switch the VideoSourceMode to a mode matching the new set value.", "The second embodiment of the present invention taking this point into consideration will be explained below.", "Note that an explanation of the same portions as those of the first embodiment will be omitted.", "FIG.", "6D is a view showing processing when a monitoring camera 1000 has received the GetVideoSourceConfigurationOptions command from a client apparatus 2000.In step S1300, a control unit 1001 refers to the table shown in FIG.", "4 which is stored in a storage unit 1002, and obtains all possible choices of the resolution of the VideoEncoderConfiguration.", "That is, the control unit 1001 obtains E1 to E4 in S1, E1 to E4 in S2, and E1 to E4 in S3 as choices.", "In step S1301, the control unit 1001 refers to the table shown FIG.", "4 which is stored in the storage unit 1002, and obtains all possible choices of the compression encoding scheme of the VideoEncoderConfiguration.", "That is, the control unit 1001 obtains MotionJPEG and H.264 as choices.", "In step S1302, the control unit 1001 refers to the table shown in FIG.", "4 which is stored in the storage unit 1002, and obtains the maximum one of possible values of the FramerateLimit of the VideoEncoderConfiguration.", "That is, the control unit 1001 obtains 30 fps as the maximum value of the FramerateLimit.", "In step S1303, the control unit 1001 obtains the choices and setting range of the VideoEncoderConfiguration independent of the current VideoSourceMode from the storage unit 1002.For example, the control unit 1001 obtains 1 to 5 as the settable range of the Quality, and 60 Mbps as the set value of the BitrateLimit.", "In step S1304, the control unit 1001 transmits a normal response containing the choices and setting range obtained in steps S1300 to S1303 to the client apparatus 2000 via a communication unit 1005.FIG.", "6E is a view showing processing when the monitoring camera 1000 has received the above-described SetVideoEncoderConfiguration command from the client apparatus 2000.In step S1400, the control unit 1001 refers to the table shown in FIG.", "4 which is stored in the storage unit 1002, and determines whether the resolution set in the received SetVideoEncoderConfiguration command matches the current VideoSourceMode.", "If the resolution matches the mode (Yes in step S1400), the control unit 1001 advances the process to step S1201.If the resolution does not match the mode (No in step S1400), the control unit 1001 advances the process to step S1410.In step S1410, the control unit 1001 refers to the table shown in FIG.", "4 which is stored in the storage unit 1002, and switches the current VideoSourceMode to a VideoSourceMode having a matched input resolution.", "For example, when 640×480 is input as a Resolution to this command while the VideoSourceMode is S1, the VideoSourceMode is switched to S3 matching this resolution.", "When the resolution is changed to a resolution different from the setting of an image capturing unit (the resolution of the VideoSourceMode) by the command for setting the resolution of the encoding unit (the resolution of a distribution image), the control unit 1001 changes the setting of the resolution of the image capturing unit to a resolution matching the resolution of the encoding unit.", "Processes in steps S1201 to S1204 and S1210 are the same as those shown in FIG.", "6C.", "FIG.", "7B is a view showing an example of a setting screen of the client apparatus 2000 in which the VideoSourceMode and VideoEncoderConfiguration of the monitoring camera 1000 according to this embodiment are set.", "An area 9012 is an area for selecting the resolution of a VideoEncoderConfiguration 6103.The GetVideoEncoderConfigurationOptions command is executed when the setting screen shown in FIG.", "7B is opened.", "A dropdown list 9100 displays the contents of the choices of a Resolution parameter obtained by the GetVideoEncoderConfigurationOptions command.", "As shown in FIG.", "6D, the monitoring camera 1000 according to this embodiment provides all resolutions obtained from the table shown in FIG.", "4 as choices.", "Therefore, the dropdown list 9100 displays all the resolutions.", "The monitoring camera 1000 provides the client apparatus 2000 with all possible setting contents of the VideoEncoderConfiguration as choices, regardless of the VideoSourceMode.", "If a parameter of the VideoEncoderConfiguration not matching the current VideoSourceMode, which includes the resolution of a compression encoding unit 1004, is designated, it is possible to internally switch to a matching VideoSourceMode.", "Accordingly, when obtaining a distribution image after the parameter of the VideoEncoderConfiguration is changed, the client apparatus 2000 need not change the setting contents of the VideoSourceMode to contents matching the VideoEncoderConfiguration.", "That is, even when various settings including the resolution of a distribution image to be generated by the compression encoding unit 1004 are changed, it is possible to prevent the occurrence of mismatching in the resolution of image data to be generated by an image capturing unit 1003.It is also possible to facilitate generating a distribution image after the resolution is changed.", "The operations of the monitoring camera, application program, and client apparatus according to the present invention have been disclosed in the first and second embodiments.", "However, the spirit and scope of the invention are not limited to the above-described embodiments, and partially changeable.", "For example, in step S1002 of FIG.", "6A, the set values of the Resolutions of the VideoEncoderConfigurations are uniformly changed to a resolution having the same management number matching the VideoSourceMode.", "However, the spirit and scope of the present invention are not limited to this.", "For example, of the Resolutions of the VideoEncoderConfigurations, a Resolution that keeps matching before and after the VideoSourceMode is changed can also be kept used after the VideoSourceMode is changed.", "Also, all possible choices of the resolution of the VideoEncoderConfiguration are provided in step S1300 of FIG.", "6D, but the spirit and scope of the present invention are not limited to this.", "For example, it is also possible to provide only a resolution matching the current VideoSourceMode as a choice, only when a video stream having a given resolution has already been distributed from the monitoring camera 1000.Furthermore, all possible compression encoding schemes of the VideoEncoderConfiguration are obtained as choices in step S1301 of FIG.", "6D, but the present invention is not limited to this.", "It is also possible to obtain only choices of compression encoding schemes matching all VideoSourceModes.", "This makes it possible to reduce the choice providing range, and prevent the SetVideoEncoderConfiguration command from designating compression encoding that does not match the VideoSourceMode selected at that point of time in step S1201.In addition, the maximum one of all possible values of the FramerateLimit of the VideoEncoderConfiguration is obtained in step S1302 of FIG.", "6D, but the present invention is not limited to this.", "For example, it is also possible to obtain the maximum FramerateLimit matching all VideoSourceModes.", "This makes it possible to reduce the choice providing range, and prevent the SetVideoEncoderConfiguration command from designating a FramerateLimit that does not match the VideoSourceMode selected at that point of time in step S1201.Also, in step S1410 of FIG.", "6E, VideoSourceModes are selectively switched based on the setting of the resolution of the SetVideoEncoderConfiguration command.", "However, the spirit and scope of the present invention are not limited to this.", "That is, a plurality of matching VideoSourceModes may exist.", "Accordingly, it is also possible to select the most matching VideoSourceMode based not only on the resolution but also on a plurality of other settings of the compression encoding unit, such as the compression encoding scheme and FramerateLimit.", "In the present invention as described above, even when only one of the resolution of image data to be generated by the image capturing unit and the resolution of a distribution image to be generated by the compression encoding unit is changed, it is possible to prevent the occurrence of mismatching in a combination of these resolutions.", "Other Embodiments Embodiments of the present invention can also be realized by a computer of a system or apparatus that reads out and executes computer executable instructions recorded on a storage medium (for example, non-transitory computer-readable storage medium) to perform the functions of one or more of the above-described embodiment (s) of the present invention, and by a method performed by the computer of the system or apparatus by, for example, reading out and executing the computer executable instructions from the storage medium to perform the functions of one or more of the above-described embodiment (s).", "The computer may comprise one or more of a central processing unit (CPU), micro processing unit (MPU), or other circuitry, and may include a network of separate computers or separate computer processors.", "The computer executable instructions may be provided to the computer, for example, from a network or the storage medium.", "The storage medium may include, for example, one or more of a hard disk, a random-access memory (RAM) , a read only memory (ROM), a storage of distributed computing systems, an optical disk (such as a compact disc (CD) , digital versatile disc (DVD), or Blu-ray Disc (BD)™), a flash memory device, a memory card, and the like.", "While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments.", "The scope of the following claims is to be accorded the broadest interpretation so as to encompass all such modifications and equivalent structures and functions." ] ]
Patent_15876005
[ [ "VENTED RESERVOIR FOR MEDICAL PUMP", "The present invention concerns a medical pump comprising: a.", "A hard housing comprising a top (24) and bottom (1) hard shells, within which a rigid wall (3) and a movable membrane (2) create three distinct chambers; wherein i. said movable membrane tightly separates said second (29) and third (22) chambers ii.", "said first and third chambers have a watertight interface iii.", "said second chamber (29) is designed to contain a fluid iv.", "said first chamber (23) comprises a first venting mean (20) which is arranged to provide a fluidic communication between said first chamber (23) and the external environment; v. said third chamber (22) comprises a second venting mean which is arranged to provide a fluidic communication between said third chamber (22) and the external environment b.", "A pumping element (4) located in the first chamber (23) c. A least one pressure sensor which measure the pressure gradient between the first chamber (23) and the second chamber (29) d. A fluid pathway which permits: i. a first fluid connection (27) between said second chamber (29) and said pumping element ii.", "a second fluid connection (28) between said pumping element and a patient line (30)." ], [ "1.-25.", "(canceled) 26.A delivery medical device comprising a movable membrane and a rigid wall arranged into a hard housing having a bottom hard shell and a top hard shell; wherein at least one of the movable membrane and the rigid wall define into the housing a first chamber, a second chamber intended to store a fluid to be delivered to a patient and a third chamber; wherein the second chamber and the third chamber are tightly separated by the movable membrane and the first chamber and the third chamber are watertightly separated by at least one of the rigid wall and the movable membrane; wherein the delivery medical device further comprises: a fluid pathway configured to provide a fluid communication between the second chamber and the patient; a pumping device configured to convey the fluid through the fluid pathway to the patient; a vent device configured to vent at least one of the first chamber and the third chamber to the external environment of the delivery medical device; and a pressure transducer having a reference port in the first chamber.", "27.The device according to claim 26, wherein the vent device comprises a first vent configured to vent the first chamber to the external environment of the delivery medical device.", "28.The device according to claim 27, wherein the first vent is a hydrophobic vent.", "29.The device according to claim 26, wherein the pumping device is arranged into the first chamber.", "30.The device according to claim 26, wherein the vent device comprises a second vent configured to vent the third chamber to the external environment of the delivery medical device.", "31.The device according to claim 30, wherein the second vent provides an air communication and a liquid communication between the external environment and the third chamber.", "32.The device according to claim 30, wherein the second vent comprises a passage which extends toward the third chamber up to a baffle.", "33.The device according to claim 32, wherein the baffle has two opposite holes.", "34.The device according to claim 32, wherein the baffle provides a mechanical protection against a tip object from the external environment.", "35.The device according to claim 26, wherein the pressure transducer is a gauge pressure sensor.", "36.The device according to claim 26, wherein the pressure transducer measures the pressure gradient between said first chamber and said second chamber.", "37.The device according to claim 26, further comprising a processing device configured to detect an under or over pressure in said first chamber and/or said third chamber.", "38.The device according to claim 26 further comprising a battery arranged into the first chamber.", "39.A delivery medical device comprising a movable membrane and a rigid wall arranged into a hard housing having a bottom hard shell and a top hard shell; wherein at least one of the movable membrane and the rigid wall define into the housing a first chamber, a second chamber intended to store a fluid to be delivered to a patient and a third chamber; wherein the second chamber and the third chamber are tightly separated by the movable membrane and the first chamber and the third chamber are watertightly separated by at least one of the rigid wall and the movable membrane; wherein the delivery medical device further comprises: a fluid pathway configured to provide a fluid communication between the second chamber and the patient; a pumping device configured to convey the fluid through the fluid pathway to the patient and arranged into the first chamber; a vent device configured to vent at least one of the first chamber and the third chamber to the external environment of the delivery medical device; and a pressure transducer configured to measure the fluid pressure in the fluid pathway.", "40.The device according to claim 39, wherein the vent device comprises a first vent configured to vent the first chamber to the external environment of the delivery medical device.", "41.The device according to claim 40, wherein the first vent is a hydrophobic vent.", "42.The device according to claim 39, wherein the vent device comprises a second vent configured to vent the third chamber to the external environment of the delivery medical device.", "43.The device according to claim 42, wherein the second vent provides an air communication and a liquid communication between the external environment and the third chamber.", "44.The device according to claim 42, wherein the second vent comprises a passage which extends toward the third chamber up to a baffle.", "45.The device according to claim 44, wherein the baffle provides a mechanical protection against a tip object from the external environment.", "46.The device according to claim 39, wherein the pressure transducer measures the pressure gradient between said first chamber and said second chamber.", "47.The device according to claim 39, further comprising a processing device configured to detect an under or over pressure in said first chamber and/or said third chamber.", "48.A delivery medical device comprising a movable membrane and a rigid wall arranged into a hard housing having a bottom hard shell and a top hard shell; wherein at least one of the movable membrane and the rigid wall define into the housing a first chamber, a second chamber intended to store a fluid to be delivered to a patient and a third chamber; wherein the second chamber and the third chamber are tightly separated by the movable membrane and the first chamber is watertightly separated from the third chamber by a watertight interface; wherein the delivery medical device further comprises: a fluid pathway intended to provide a fluid communication between the second chamber and the patient; a pumping device configured to convey the fluid through the fluid pathway to the patient; a vent device having a passage which extends toward the third chamber up to a baffle configured to vent the third chamber to the external environment of the delivery medical device; and a pressure transducer in pressure communication with the fluid pathway.", "49.The device according to claim 48, wherein the pumping device is arranged into the first chamber.", "50.The device according to claim 48, wherein the vent device provides an air communication and a liquid communication between the external environment and the third chamber.", "51.The device according to claim 48, wherein the baffle provides a mechanical protection against a tip object from the external environment.", "52.The device according to claim 48, wherein the pressure transducer measures the pressure gradient between said first chamber and said second chamber.", "53.The device according to claim 48, further comprising a processing device configured to detect an under or over pressure in said first chamber and/or said third chamber." ], [ "<SOH> FIELD OF THE INVENTION <EOH>The present invention is related to medical pumps, more specifically to reservoirs used with insulin pumps and means to prevent and detect any over or under pressure in the reservoir." ], [ "FIELD OF THE INVENTION The present invention is related to medical pumps, more specifically to reservoirs used with insulin pumps and means to prevent and detect any over or under pressure in the reservoir.", "STATE OF THE ART Some insulin pumps, such as the one illustrated on FIG.", "1, have a rigid chamber defined between a rigid wall (3) and bottom (1) hard shell.", "A pumping element (4) is fixed to the rigid wall (3).", "The chamber contains a reservoir which is made of a movable membrane (2) (e.g.", "soft pouch or flexible film), such as thermoformed and heat-soldered onto the rigid wall (3) (see for instance international patent application WO 2007/113708).", "The bottom hard shell (1) protects the membrane (2) against external mechanical forces and ensures a water tightness of the system.", "The pump is vented using a hydrophobic filter in order to prevent a pressurization of the reservoir due to pressure or temperature changes.", "The risk of clogging with this filter is high and therefore a potential overdose becomes possible.", "Moreover such clogging cannot be detected with the gauge pressure detector of the pump because the reference port of the detector is vented by the same filter than the reservoir itself.", "Therefore, said device described by WO 2007/113708 can't detect a possible clogging of this vent which cause an over or under delivery of the insulin to the patient.", "The implementation of an additional anti-free-flow valve is a possible way to overcome this problem.", "See WO 2008/029051.However, this may be expensive for a disposable product and may not be totally fail safe.", "GENERAL DESCRIPTION OF THE INVENTION The present invention provides another advantageous solutions to prevent an over or under delivery of fluid to the patient (for example: insulin) which is induced when the pressure gradient between the reservoir and the external environment changes.", "Furthermore, the present invention may advantageously use with a method described in the application EP 11172494.4.To this effect, it relates to a medical pump comprising three distinct chambers.", "Said medical device is designed to form a hard housing comprising a top and bottom hard shells.", "Said housing further comprises a hard wall and a movable membrane which create said three distinct chambers.", "Said movable membrane tightly separates the second and the third chambers.", "The first and third chambers have a watertight interface.", "Said second chamber is designed to contain a fluid.", "Said movable membrane may be moved between said rigid wall and the bottom hard shell, in such a way that the fluid tight reservoir is formed by the second chamber.", "Said first chamber comprises a first venting mean which is arranged to provide a fluidic communication between said first chamber and the external environment.", "Said third chamber comprises a second venting mean which is arranged to provide a fluidic communication between said third chamber and the external environment.", "The device further comprises a pumping element located in the first chamber, at least one pressure sensor which measures the pressure gradient between the first chamber and the third chamber.", "Said medical device comprises a fluid pathway which permits a first fluid connection between said second chamber and said pumping element and a second fluid connection between said pumping element and a patient line.", "With the present invention, the third chamber is completely vented by said second venting mean while maintaining the protection against mechanical forces or ingress of solid foreign objects such as sharp tips.", "In one of embodiment, said second venting mean is formed by several passages.", "The protection against water ingress is not insured for the third chamber, which is not necessary if said movable member is a tight membrane.", "While, the first chamber is vented by a vent which may be hydrophobic and or oleophobic to protect the electronic part.", "In one of embodiment, said movable membrane may transmit the pressure of the third chamber to said first fluid connection via the second chamber and the movable membrane.", "If, one or the both venting means get clogged, the pressure in the device and the pressure of the external environment may be different.", "The pressure gradient between inside device, in particular in the third chamber, and the external environment may induce an over or under delivery of the fluid to the patient.", "For this reason, the second venting mean comprises several passages (which reduce the clogging risk) and the device uses a method partially described in the application EP 11172494.4 for detecting if at least one venting means is clogged.", "The sensors may be localised in said chambers, in said fluid connections and/or outside.", "The sensor may be a gauge pressure sensor localised between: the third chamber and the first chamber, and/or said first fluid connection and the first chamber, and/or said second fluid connection and the first chamber, and/or said third chamber and external environment, and/or said first chamber and external environment.", "The reference port of said gauge pressure sensors may be the external environment, the first chamber or the third chamber.", "In one of embodiment, the device comprises processing means for the sensor signal which may measure the pressure gradient between the third chamber and the first chamber or the external environment.", "And said processing means detect a under or over pressure in said first chamber and/or said third chamber.", "Said processing means can detect the clogging of said first venting mean and/or said second venting mean.", "The medical pump comprises alarm means which alert the patient in case of said first venting mean and/or said second venting mean are clogged.", "LIST OF FIGURES FIG.", "1 shows the prior art of the medical device without the holes.", "FIG.", "2 illustrates an embodiment of the invention with several holes on one of hard shells FIG.", "3 represents the same embodiment as the one illustrated on FIG.", "2 but viewed from the other side.", "FIG.", "4 shows an exploded view of the complete system.", "FIG.", "5 shows the embodiment of the medical device with both venting means are directly connected to the external environment.", "FIG.", "6 shows another embodiment of the medical device with the first venting mean located between the first and the third chambers.", "LIST OF ELEMENTS 1 Bottom hard shell 2 Movable membrane 3 Rigid wall 4 Pumping element 5 Holes 6 Baffles 7 Second venting mean 8 Upper face of the second chamber and/or third chamber 9 Lower face of the third chamber 10 Lateral face of the third chamber 11 Marks on the bottom shell 12 Filling port of the second chamber 13 Lateral slides 14 Grips 16 Battery 17 PCB (Printed Circuit Board) 18 Spring contacts 19 Battery contact 20 First venting mean 21 Lock 22 Third chamber 23 First chamber 24 Top hard shell 25 Upper face of the first chamber 26 Lower face of the first chamber 27 First fluid connection 28 Second fluid connection 29 Second chamber 30 Patient line DETAILED DESCRIPTION OF THE INVENTION The medical pump of the present invention comprises three distinct chambers (23, 29, 22).", "The second chamber (29) and the third chamber (22) is separated by a movable membrane (2) which may be moved between a bottom hard shell (1) and the rigid wall (3) and comprises an upper face (8), a lower face (9) and a lateral face (10).", "Said bottom shell (1) contains several holes (5) which are forming the internal ends of passages (7) communicating between the third chamber and the external environment.", "The first chamber (23) is defined between the top hard shell (24) and the rigid wall (3).", "Said first chamber (23) comprises an upper face (25), a lower face (26), a pumping element (4) and a first venting mean (20).", "The third chamber and the first chamber are tightly separated by at least said rigid wall (3) which is designed to form a watertight interface.", "In one of said embodiments, a hydrophobic surface treatment or coating can also be used on and/or around the holes (5) to limit the water ingress.", "In one of said embodiments, said first chamber (23) comprises the electronic elements.", "In one of said embodiments, the lateral faces of said chambers are formed by the junction between part of the top and the bottom hard shell of the medical device.", "The medical device comprises a first fluid connection (27) between said second chamber (29) and said pumping element, and a second fluid connection (28) between said pumping element and the patient line.", "A sensor may measure a pressure gradient between the fluid and said first chamber (23) and/or said third chamber (22) or between said both chambers.", "Said sensor can be located upstream and/or downstream of the pumping element (4).", "In a preferred embodiment, the sensor is a gauge pressure sensor.", "The reference port of said gauge pressure sensor is connected to said first chamber (23), allowing the detection of under or over pressure between: said third and first chambers, and/or the fluid and said first chamber, and/or the fluid and said third chamber, and/or the fluid and the patient line.", "In case of one or both of said venting means are clogged, a positive or negative pressure may be trapped in the third chamber (22) and/or in the first chamber (23).", "Therefore, the device further comprises alarm means which can alert the patient if the first venting mean (20) of the first chamber or/and the second venting mean (7) of said third chamber (22) are clogged.", "Vent clogging case studies: In a preferred embodiment, the change of pressure due to clogging can be monitored using two gauge sensors located in the pumping element.", "A first gauge pressure sensor is located in the first fluid connection (27) which may measure the pressure of the third chamber which is transmitted to the second chamber (29) (and the first fluid connection (27)) via the movable membrane (2).", "A second gauge pressure sensor is located in the second fluid connection (28) which may measure the pressure of the patient line.", "For both sensors, the reference port is the first chamber (23).", "1.Clogging of the second venting mean (7) only→potential over or under pressure in the third chamber (22) is transmitted to the fluid in the second chamber (29) via the membrane (2) and is detected via the first sensor since the reference port (the first chamber (23)) of said sensor is not pressurized.", "The first sensor detects a pressure gradient between the third chamber (22) and the first chamber (23) while the second sensor doesn't detect any pressure gradient between the patient line and the first chamber (23).", "2.Clogging of the first venting mean (20) only→the first chamber (23) and therefore the reference ports of both sensors shall potentially exhibit over or under pressure with respect to external environment.", "Said over or under pressure will be detected by both sensors.", "Positive (respectively negative) pressure in said first chamber (23) leads to a pressure signal equivalent to a negative (resp.", "positive) pressure in the pumping chamber in normal conditions.", "Therefore, a clogging of said first venting mean (20) is detected when the pressure in the first chamber (23) becomes different from external environment pressure.", "Said difference of pressure inducing the same offset on both gauge pressure sensors with respect to a reference value obtained either by measuring the pressure sensor signal before the priming of the pump or by using calibration data.", "3.Clogging of all venting ports→the first and third chambers (23, 22) are potentially in over or under pressure with respect to the external environment.", "Therefore, the first sensor can't detect any pressure gradient between the first and the second or third chambers.", "But, the patient line pressure may be different.", "Therefore, the second sensor can detect a pressure gradient between the first chamber (23) and the patient line.", "FIG.", "2 illustrates an embodiment of the invention where the bottom shell (1) is provided with passages (7) on its lateral face (10) of the third chamber.", "Each passage (7) is provided with a baffle (6) which defines two opposite holes (5) oriented towards said lateral face (10), in a direction which is parallel with respect to the bottom face.", "In another embodiment, the holes are located within said lateral face (10) or said lower face (9) of the third chamber.", "In a preferred embodiment, said holes (5) are oriented in a direction which is forming an angle above 30° with the main direction of their respective passages (7).", "FIG.", "4 shows an exploded view of the complete system, including the same embodiment as to the one illustrated on FIG.", "2 and the top hard shell (24), the battery (16), a lock (21), the first venting mean (20), a PCB (17) and its spring contacts (18) to connect the pumping element (4) (not showed here) and finally the battery contact (19).", "In the present invention the design of the bottom shell and more particularly the second venting mean (7) are driven by: The capability to vent the membrane (2) for any foreseeable use or probable misuse of the pump, including the presence of dirt onto the pump, the wearing of the pump under clothes .", ".", ".", "The protection against solid foreign objects When second venting means (7), which is several passages like holes (5), are provided in the bottom shell (1) it is not possible to accidentally close all openings because of their specific locations.", "The compression of the pump against a soft material on the top shell cannot typically obstruct these passages because of their lateral orientated location.", "The closure of the passages by lateral compression is also prevented by baffles (6) that limit the access typically to fingers.", "The passages (7) may have the shape of a slit or any other shape having one dimension preferably lower than 1 mm.", "The passages (7) may also be made into a recess and oriented perpendicularly to the normal of the lateral face (10) of the third chamber (22) in order to prevent the insertion of a straight and rigid tip, the minimum dimension of the opening being preferably no longer limited to 1 mm in this configuration according to this recess.", "The bottom shell (1) is preferably transparent; the patient should be able to see any large obstruction due to foods or any sticky stuff and eventually to change the disposable.", "The bottom shell (1) and/or the rigid wall (3) and/or the membrane (2) are preferably is made in plastic, and more generally in any material having specific grades compatible with insulin.", "The use of the same material is desirable for thermowelding.", "The contact surfaces for gluing or thermowelding between the top and bottom shell should be large enough to withstand reservoir overpressure up to 1 bar and drop test from a height of 1 meter or more.", "The membrane material has ideally a low elasticity and a low permeability.", "The membrane thickness is typically smaller than 100 microns.", "The surface of the membrane (2) is ideally larger than the surface of the lower face (9) of the third chamber (22) of the bottom shell to prevent any in-plane stress in the membrane and therefore any effect due to the membrane elasticity.", "The bottom shell (1) can advantageously include Moiré pattern.", "In case of overfilling of the reservoir, when the membrane is directly in contact with the bottom shell, the reservoir pressure would bend the bottom shell and induce changes in the Moiré pattern, giving a visual feedback of overfilling to the patient.", "The Moiré pattern covers partly the bottom shell (1) surface in order to make possible the observation of bubbles into the reservoir.", "The bottom shell may include any means to detect deformation due to static load or a pressurized reservoir (e.g.", "strain gauges, pressure sensors .", ".", ".", ").", "The passages (7) may be partly or completely covered by a removable and permeable tape that ensures the venting of the reservoir.", "In case of projection of sticky stuff on the passages (7) the patient can advantageously remove the tape instead of trying to clean up the device or simply changing it.", "The tape may be made of several sheets that can be removed iteratively.", "Such air permeable tape may also cover the first venting mean (20) of the first chamber (23).", "The bottom shell (1) may include marks (11) that help the patient to find the filling port (12) containing a septum.", "The bottom shell (1) is ideally flat and has lateral slides (13) for patch insertion (clipping) and grips (14) for patch removal (unclipping).", "Fluid, e.g.", "water, can flow through the passages (7) and then in the space between the bottom shell (1) and the membrane (2), the fluid tightness being only provided to the first chamber (23) of the pump which, among other elements, includes the battery (16).", "The electronic and pump controller are in the first chamber which is water tight but has to be vented in case a zinc-air battery needing oxygen and when a gauge pressure sensors are used.", "The first chamber (23) is tightly assembled using lock (21) or clips or any other means onto the upper face of the rigid wall (3), contacting electrically the pads of the pump via the spring contacts (18) of the Printed Circuit Board (PCB) (17).", "The first chamber (23) uses the first venting mean (20) which is therefore preferably hydrophobic and/or oleophobic.", "In another embodiment (FIG.", "6), the first venting mean (20), which is hydrophobic, is located between the first and the third chambers.", "In another embodiment, the device further comprises three distinct venting means.", "The first venting mean connects directly the first chamber to the external environment, the second venting mean connects directly the third chamber to the external environment and the third venting mean is located between the third and the first chamber.", "This embodiment insure a good venting in third and first chambers even if one venting mean is clogged.", "Said third venting mean is preferably hydrophobic and/or oleophobic." ] ]
Patent_15876006
[ [ "FOOD POUCH CONTAINER", "A rigid food pouch container developed to accommodate prepared food packaged in soft containers is designed to prevent a child from squeezing the container and causing its contents to spurt from the container.", "The food pouch container includes a back portion having an interior cavity; a front portion; a top hole; and a surface dividing the back portion into an upper cavity and a lower cavity.", "In some embodiments, the lower cavity is inside the back portion, while in other embodiments, the lower cavity is an exterior cavity.", "Also disclosed are food pouch containers that include a back portion having an interior cavity; a front portion; a top hole; means for contouring the food pouch from the bottom or side of the pouch.", "Some embodiments include a hinged clam shell configuration for easy insertion and removal of the food pouch.", "Other embodiments include a storage facility for the pouch cap." ], [ "1.A container for a food pouch having a flat shape for holding soft food, the pouch further having a mouthpiece portion and a removable cap for the mouthpiece, the container comprising: a rigid body configured to surround the pouch and sized for nesting of the pouch inside the body; the body having an opening for the mouthpiece to protrude outside the body; said opening being sized and shaped to fit closely about a hollow neck of a food pouch without constricting said hollow neck; the body being contoured to change the pouch to a bulbous shape; and thereby enabling the soft food to be more easily emptied out of the pouch.", "2.The container of claim 1, wherein the container comprises at least one handle.", "3.The container of claim 1, wherein the body contours the sides of the pouch.", "4.The container of claim 1, wherein the container comprises at least one side pinch.", "5.The container of claim 1, further comprising a front portion and a back portion.", "6.The container of claim 5, further comprising at least one latch configured to releasably lock the front portion and the back portion together when the container is in a closed configuration.", "7.The container of claim 5, wherein the front portion is attached to the back portion via a hinge.", "8.The container of claim 5, wherein the back portion comprises a first perimeter groove and the front portion comprises a second perimeter groove.", "9.A container for a food pouch having a flat shape for holding soft food, the pouch further having a mouthpiece portion and a removable cap for the mouthpiece, the container comprising: a body having an interior cavity, wherein the body has a base, sidewalls extending upwardly from the base and a top panel; the interior cavity being sized and shaped to surround the pouch and sized for nesting of the pouch inside the interior cavity; a hole, said hole being sized and shaped to fit closely about a hollow neck of a food pouch without constricting said hollow neck; 10.The container of claim 9, wherein the container comprises at least one handle.", "11.The container of claim 9, wherein the body contours the sides of the pouch.", "12.The container of claim 9, wherein the container comprises at least one side pinch.", "13.The container of claim 9, wherein the top panel is attached to a sidewall via a hinge.", "14.The container of claim 13, further comprising at least one latch configured to releasably lock the top panel to a sidewall when the container is in a closed configuration.", "15.The container of claim 9, further comprising a front portion and a back portion.", "16.The container of claim 15, further comprising at least one latch configured to releasably lock the front portion and the back portion together when the container is in a closed configuration.", "17.The container of claim 15, wherein the front portion is attached to the back portion via a hinge.", "18.The container of claim 15, wherein the back portion comprises a first perimeter groove and the front portion comprises a second perimeter groove.", "19.A container for a food pouch having a flat shape for holding soft food, the pouch further having a mouthpiece portion and a removable cap for the mouthpiece, the container comprising: a rigid body configured to surround the pouch and sized for nesting of the pouch inside the body; the body having an opening for the mouthpiece to protrude outside the body; said opening being sized and shaped to fit closely about a hollow neck of a food pouch without constricting said hollow neck; a door; the body being contoured to change the pouch to a bulbous shape; and thereby enabling the soft food to be more easily emptied out of the pouch.", "20.The container of claim 19, further comprising at least one side pinch.", "21.The container of claim 19, further comprising a surface for contouring the bottom of a food pouch.", "22.The container of claim 21, wherein the surface divides the body into an upper cavity and a lower cavity.", "23.The container of claim 21, where in the surface is curved downward." ], [ "<SOH> BACKGROUND OF THE DISCLOSURE <EOH>Recently, there has been an increased growth in the use and marketing of food pouches, also referred to as stand-up pouches, especially for use with baby food.", "The food pouches are easy to use for the parents and the children can suck the food out of the pouch.", "The use of the food pouch eliminates the need for a glass baby food jar, and the need to spoon feed the food to the infant or toddler, thereby reducing the mess that is often accompanied when one is feeding a child.", "However, the food pouches themselves can create mess.", "Invariably, the flow of food through the opening of the pouch is not controlled.", "Therefore, when the child squeezes the food pouch, the food squirts from the top opening and can soil the child's clothing or chair.", "Thus, there is a need in the art to retain the convenience of the food pouch but reduce or prevent the accompanying mess that the use of the pouch produces." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>Disclosed herein are food pouch containers comprising a back portion having an interior cavity; a front portion; a top hole; and a surface dividing the back portion into an upper cavity, inside the back portion, and a lower cavity.", "In some embodiments, the lower cavity is inside the back portion, while in other embodiments, the lower cavity is an exterior cavity.", "Also disclosed are food pouch containers comprising a back portion having an interior cavity; a front portion; a top hole; means for contouring the food pouch from a bottom thereof; and means for contouring the food pouch from at least a side thereof." ], [ "RELATED APPLICATIONS The present application claims priority to U.S. application Ser.", "No.", "14/340,547 filed Jul.", "24, 2014, currently pending and to U.S.", "Provisional Application Ser.", "No.", "61/929,206, filed on Jan. 20, 2014, both by Timothy Fellin et al., and entitled “FOOD POUCH CONTAINER,” the entire disclosures of which are incorporated by reference herein, including the drawings.", "FIELD OF THE INVENTION The present invention is in the field of food containers, and in particular in the field of containers for food pouches.", "BACKGROUND OF THE DISCLOSURE Recently, there has been an increased growth in the use and marketing of food pouches, also referred to as stand-up pouches, especially for use with baby food.", "The food pouches are easy to use for the parents and the children can suck the food out of the pouch.", "The use of the food pouch eliminates the need for a glass baby food jar, and the need to spoon feed the food to the infant or toddler, thereby reducing the mess that is often accompanied when one is feeding a child.", "However, the food pouches themselves can create mess.", "Invariably, the flow of food through the opening of the pouch is not controlled.", "Therefore, when the child squeezes the food pouch, the food squirts from the top opening and can soil the child's clothing or chair.", "Thus, there is a need in the art to retain the convenience of the food pouch but reduce or prevent the accompanying mess that the use of the pouch produces.", "SUMMARY OF THE INVENTION Disclosed herein are food pouch containers comprising a back portion having an interior cavity; a front portion; a top hole; and a surface dividing the back portion into an upper cavity, inside the back portion, and a lower cavity.", "In some embodiments, the lower cavity is inside the back portion, while in other embodiments, the lower cavity is an exterior cavity.", "Also disclosed are food pouch containers comprising a back portion having an interior cavity; a front portion; a top hole; means for contouring the food pouch from a bottom thereof; and means for contouring the food pouch from at least a side thereof.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates an embodiment of the food pouch container disclosed herein in its closed configuration.", "FIG.", "2 illustrates an embodiment of the food pouch container disclosed herein in its open configuration.", "FIG.", "3A illustrates the view of the interior of an embodiment of the back portion of the food pouch container disclosed herein in its open configuration.", "FIG.", "3B illustrates the view of the interior of an embodiment of the front portion of the food pouch container disclosed herein in its open configuration.", "FIG.", "3C illustrates the bottom view of an embodiment of the back portion of the food pouch container disclosed herein in its open configuration.", "FIG.", "4 illustrates the view of the interior of an embodiment of the back portion of the food pouch container disclosed herein in its open configuration.", "FIG.", "5A illustrates the top view of an embodiment of the food pouch container disclosed herein in its closed configuration.", "FIG.", "5B illustrates the top view of another embodiment of the food pouch container disclosed herein in its closed configuration.", "FIG.", "6 illustrates an embodiment of a surface-adjusting mechanism disclosed herein.", "FIG.", "7 illustrates the cross section of an embodiment of the food pouch container disclosed herein.", "FIG.", "8 illustrates the cross section of another embodiment of the food pouch container disclosed herein.", "FIG.", "9A illustrates the side view of an embodiment of the food pouch container disclosed herein in its closed configuration.", "FIG.", "9B illustrates the side view of another embodiment of the food pouch container disclosed herein in its closed configuration.", "FIG.", "10A illustrates the perspective view of an embodiment of the food pouch container disclosed herein, having handles, in its open configuration.", "FIG.", "10B illustrates the front view of an embodiment of the food pouch container disclosed herein, having handles, in its closed configuration.", "FIGS.", "11A-11C illustrate an embodiment of the food pouch container disclosed herein in its closed configuration.", "FIG.", "11D illustrates the interior of the same embodiment of the food pouch container.", "FIG.", "12A illustrates an embodiment of the food pouch container disclosed herein in its open configuration.", "FIG.", "12B illustrates the front portion and FIG.", "12C illustrates the back portion thereof.", "DETAILED DESCRIPTION OF THE EMBODIMENTS Disclosed herein are containers for holding a food pouch.", "The interior of the containers disclosed herein comprise elements on the sides and the bottom that are designed to contort the shape of the food pouch in such a way as to allow the food to easily be accessible to the user, e.g., a child, regardless of the amount of food left in the pouch.", "Some embodiments of the presently disclosed containers prevent the area around the neck of the pouch to collapse and create a vacuum.", "The various embodiments of the presently disclosed containers are now described in view of the drawings.", "FIG.", "1 shows an embodiment of the presently disclosed container 100 in its closed formation.", "The container 100 comprises a body, having a front portion 102 and a back portion 104.The container 100 also comprises a top opening 106, from which the nozzle or mouthpiece of a food pouch protrudes once the food pouch is placed inside the container 100.In some embodiments, tabs 108 are placed on either side of the container 100, which are configured to ease the opening of the container 100 so that a new pouch can be placed therein or a used pouch be removed therefrom.", "The body is constructed of a rigid, childsafe material, such as plastic, wood, shatterproof glass, metal, or other rigid material, which holds the food pouch or food bag and preferably prevents a consumer from expelling the contents of the food pouch or food bag by squeezing.", "FIG.", "2 shows an embodiment of the presently disclosed container 100 in its open formation.", "In some embodiments, for example that shown in FIG.", "2, the front portion 102 and the back portion 104 are attached together at the bottom of the container 100, i.e., the side opposite of the top opening 106, by a hinge 202, which is described more fully below.", "In other embodiments, when the container 100 is opened, the front portion 102 and the back portion 104 become separated.", "In some embodiments, for example that shown in FIG.", "2, the top opening 106 comprises of two semicircle sections.", "One semicircle portion 204 is cut into the front portion 102, whereas another semicircle 206 is cut into the back portion 104.In some embodiments, the semicircles 204 and 206 are of the same size, i.e., they each define an arc of 180°.", "In other embodiments, and primarily depending on the thickness of the top edges of the front portion 102 and the back portion 104, the semicircles 204 and 206 may be of a different size.", "For example, one of the semicircles 204,206 defines an arc >180°, while the other of the semicircles 204,206 defines an arc <180°.", "In some embodiments (not shown), the top opening 106 is in the shape of a square, a rectangle, a rhombus, a parallelogram, a triangle, a trapezoid, or another geometric shape.", "In these embodiments, the front portion 102 and the back portion 104 comprise the two halves of the top opening 106, which when the container 100 is closed, the two halves form the square or the rectangle.", "Thus, in these embodiments, the front portion 102 and the back portion 104 do not comprise semicircles, but comprise the halves of the top opening 106.In some embodiments, once the container 100 is closed, the front portion 102 and the back portion 104 are held together by at least one latch.", "The latch may be placed anywhere along the perimeter of the container 100.In some embodiments, the latch is along the internal perimeter of the container 100, whereas in other embodiments, the latch is along the external perimeter of the container 100.In some embodiments, the latch is towards the top of the container 100.In these embodiments, the bottom of the container 100 comprises a hinge or other mechanism, such as a tab and slot, or a friction lock mechanism.", "In other embodiments, the latch is towards the bottom of the container 100.In these embodiments, the top of the container 100 comprises a hinge or other mechanism, such as a tab and slot, or a friction lock mechanism.", "In some embodiments, the latch is on one of the sides of the container 100.In some embodiments, for example that shown in FIG.", "2, the back portion 104 comprises two latches 208, located at either side of the top of the back portion 104.In some embodiments, each latch 208 comprises a lip 210 (also referred to as a raised member), which points outward.", "The front portion 102 comprises corresponding indents 212.When the container 100 is closed, the lip 210 of the latch 208 catches inside the indent 212 and causes the front portion 102 and the back portion 104 to remain connected.", "In other embodiments, the latch 208 engages a corresponding portion in the front portion 102 to create a friction lock.", "In the embodiment shown in FIG.", "2, the lip 210 and the indent 212 are shown as lines.", "In other embodiments, the lip 210 and the indent 212 may have another geometrical shape, for example a circle, a semicircle, or a hemisphere.", "In certain embodiments, tabs 108 are placed on the outside of the back portion 104, in a place corresponding to the latches 208.When the tabs 108 are pressed, the latches 208, and consequently the lips 210, are pushed to the interior cavity of the back portion 104.If the latches 208 are engaged with the indents 212, then pressing on the tabs 108 releases the lips 210 from the indents 212.The front portion 102 and the back portion 104 can then be easily separated.", "Tab 222 is provided on the front portion 102 to provide additional friction for when a user chooses to open the container 100.Thus, in these embodiments, to open the container 100, a user can hold the back portion 104 by the tabs 108 and the front portion 102 by the tabs 222.The user then exerts pressure on the tabs 108 to release the latches 208 from the indents 212.Then the user pulls the tabs 108 away from the tabs 222.In the embodiments, where the latches 208 form a friction lock with the front portion 102, the tabs 108 solely provide a friction hold for the user, similar to the tabs 222.While the latch mechanisms here have been described with the reference to their placement on either the front portion 102 or the back portion 104, the skilled artisan recognizes that the arrangement can easily be reversed.", "The reversed arrangement is specifically contemplated.", "In some embodiments, a surface 214 divides the interior cavity of the back portion 104 into an upper cavity 216 and a lower cavity 218.In some embodiments, for example that shown in FIG.", "2, the surface 214 is a cantilever, whereas in other embodiments, the surface 214 is a shelf.", "In certain embodiments, the surface 214 is arced, whereas in other embodiments, the surface 214 is flat.", "In some embodiments, the surface 214 is fixed in place.", "In other embodiments, the position of the surface 214 is changed upward or downward, as described more fully below.", "In some embodiments, the upper cavity 216 is configured to receive a food pouch (not shown).", "In certain embodiments, the lower cavity 218 is configured to optionally hold the cap 220 of the food pouch.", "This embodiment is illustrated in FIG.", "2.Throughout the present disclosure and the claims, the direction “up,” “top,” or “upper” refers towards the location where the mouthpiece of a food pouch fits into the container.", "The direction “down,” “lower,” or “bottom” refers towards the location where the bottom of the food pouch fits into the container.", "Thus, for example, the top hole 106 is at the top and the surface 214 is at the bottom with respect to the top hole.", "In other words, the surface 214 is “lower” than the top hole 106.Throughout the present disclosure, the “front” and “back” refer to the location of the surface 214.Thus, whichever portion that comprises the surface 214 is considered the “back” portion, regardless of how the container is held by the user.", "FIG.", "3A provides a clearer view of the back portion 104, without the presence of the front portion 102 or the cap 220.The back portion of the hinge 202 is also illustrated.", "FIG.", "3B provides a clearer view of the front portion 102 back, without the presence of the portion 104.In the illustrated embodiment, the back of the hinge 202 on the back portion 104 (FIG.", "3A) comprises a bar 302.Ridges 304,306,308,310 divide the hinge 202 portion into three areas 312, 314, and 316.The front edge of each of the areas 312,314,316 is open.", "The front of the hinge 202 on the front portion 102 (FIG.", "3B) comprises three curved members.", "The outer members 318 and 322 are arced downward whereas the central member 320 is arced upward.", "When the front portion 102 and the back portion 104 are joined together, the outer members 318 and 322 catch the bar 302 in front of areas 316 and 312, respectively, such that the bar 302 is placed under the curved members 318 and 322.Simultaneously, the central member 320 catches the bar 302 in front of area 314 such that the bar 302 is placed above the curved member 320.Thus, a hinge is formed.", "FIG.", "3C is a bottom view of the back portion 104 showing the position of the bar 302, the ridges 306,308 and the openings 324, 326, and 328 in front of the areas 312, 314, and 316, respectively.", "Other methods of forming a hinge are known in the art and are contemplated herein.", "For example, in some embodiments, the front portion 102 comprises a plurality of semicircular members that catch the bar 302, thus forming a hinge.", "In other embodiments, more or fewer curved members are placed on the front portion 102.In other embodiments, the curved members 318,320,322 are placed on the back portion 104, whereas the bar 302 is placed on the front portion 102.Any other configuration that allows for a hinge to be formed is contemplated.", "In some embodiments, the front view of the container 100 comprises a generally rectangular shape.", "In other embodiments, the front view shape of the container 100 is square.", "In other embodiments, the front view shape of the container 100 comprises another geometrical shape, for example a circle, a triangle, and the like.", "FIG.", "4 shows the front view of the back portion 104.The illustrated embodiment comprises a generally rectangular shape, with the addition of side pinches 402 at either side of the back portion 104.As can be seen from the illustrated embodiments of FIGS.", "1-3, corresponding side pinches appear on the front portion 102 as well.", "The upper cavity 216, then is defined at the top by the top of the container 100, and the top opening 206; at the bottom by the surface 214; and at the sides by the sides of the container 100 having the side pinches 402.A food pouch is placed in the upper cavity 216 such that the bottom of the food pouch rests on the surface 214, and attains the generally curved shape of the surface 214.The nozzle of the food pouch protrudes from the top opening 206.The sides of the food pouch are also curved due to the curvature caused by the side pinches 402.In some embodiments, the user can choose to store the cap of the food pouch in the lower cavity 208 while the child is consuming the food in the food pouch, thereby reducing the chances of the cap getting lost or dirty.", "The inventors have discovered that when a food pouch is partially used, vacuum is generated at the top of the food pouch and the body of the pouch collapses.", "While there is still plenty of food within the pouch, a child cannot access it easily because of the collapsed body of the pouch near the nozzle.", "The child will then need to suck forcefully, which results in the tiring of, and aches in, the jaw.", "However, in some embodiments, when the food pouch is placed in the container 100 as described herein, where the food pouch attains the curvatures discussed above, there is created a “pinch” by the side pinches 402 and a “push” by the surface 214.Consequently, in these embodiments, the body of the pouch does not collapse and the child can easily access the entirety of the food in the pouch, without having to suck forcefully.", "FIG.", "5 illustrates two embodiments of the top opening 106 of the container 100.In FIG.", "5A, the top opening 106 is circular and is configured to accommodate a food pouch having any shape nozzle.", "However, the standard nozzle for the pouches currently on the market has a square cross section.", "The embodiment of FIG.", "5B is a square top opening 106.The advantage of this embodiment is that when the food pouch is placed in the container 100, the cap of food pouch can be twisted open or closed without the need to hold the nozzle.", "In these embodiments, when the cap is twisted open or closed, the pouch itself does not twist.", "When the pouch twists, it can make it hard or impossible to suck contents out of nozzle.", "In some embodiments, the surface 214 is not fixed to the back portion 104.In these embodiments, there exists a mechanism by way of which the surface 214 is moved up or down.", "In some embodiments, for example the one shown in FIG.", "6, an adjusting mechanism 600 is incorporated into the container 100.The mechanism 600 comprises a knob 602, optionally a bottom plate 604, a threaded spindle 606, optionally a top shelf 608, and a cap 610.The mechanism 600 is incorporated such that the knob 602 is outside of the container 100, and located at the bottom thereof.", "The bottom plate 604, if present rests abutting the bottom of the container 100.The cap 610 serves the same function as the surface 214.In some embodiments, the shape of the top of the cap 610 is flat, whereas in other embodiments, the top of the cap 610 is curved, having the same design as the surface 214 shown in FIG.", "2.The top shelf 608 is optionally present to provide additional stability to the cap 610.The user can rotate the knob 602, thereby moving the cap 610 up or down, providing more or less pressure on the food pouch, as the need may be.", "In other embodiments, there is provided a boss at the bottom of the container 100, which boss is in contact with a cap.", "When the user pushes the boss in, towards the top of the container 100, the cap also moves upward providing additional pressure for the food pouch.", "Once the food pouch is used and prior to the insertion of a new food pouch, the user moves the cap back down to its original location.", "In other embodiments, there is provided a roller inside the container 100, the roller having a slot therein.", "The roller is connected with at least one knob, which is placed along a track, at the side of the container 100 on the outside.", "When the knob is turned, the roller turns as well.", "The user inserts the bottom of the food pouch in the roller's slot.", "As the knob is turned, the roller turns, thereby rolling the food pouch from the bottom, and squeezing the food out of the food pouch.", "This action is similar to rolling a toothpaste tube from the bottom.", "In yet another embodiment, shown in FIG.", "7, there is provided a container 100 having phantom walls.", "When viewed from the outside, i.e., when the container 100 is closed, the container has a generally rectangular shape.", "However, on the inside, there are solid curved side walls creating spaces 702,704 and a solid curved bottom creating space 706.The walls creating spaces 702,704 operate similarly as the side pinches 402, described above, while the bottom creating space 706 operates similarly as the surface 214, described above.", "In some embodiments, the space 702,704 and/or bottom 706 are each independently hollow (see, for example, FIG.", "11C, below), while in other embodiments, the spaces are each independently filled.", "In still another embodiment, shown in FIG.", "8, there is provided a container 100 having screwable pinches.", "One or more knobs 802 are placed at the side of the container 100.Each knob is connected to a pinch 804 via a threaded spindle 806.In some embodiments, the inward surface of the pinch 804 is flat, whereas in other embodiments, for example the one shown in FIG.", "8, the inner surface of the pinch 804 is curved.", "When the knob 802 is turned, the pinch moves inward, providing side pressure to the food pouch.", "Similarly, there is provided a bottom knob 808, which is connected to a bottom pinch 810 via a threaded spindle 812.The turning of the knob 808 causes the bottom pinch 810 to move upward, providing bottom pressure to the food pouch.", "Prior to inserting a new food pouch, the user turns the pinches to their original, fully open position, giving the maximum cavity space.", "Some embodiments comprise only side pinches 804, while other embodiments, comprise only the bottom pinch 810.Still other embodiments comprise one side pinch 804, while other embodiments comprise more than two side pinches 804 and/or two or more bottom pinches 810.In some embodiments, the front portion 102 and the back portion 104 have the same proportions.", "In these embodiments, for example as shown in FIG.", "9A, the centerline 902 is even.", "However, in some embodiments, the back portion 104 is slightly larger than the front portion 102, to provide a deeper cavity for the food pouch at the time of insertion, which makes the placement of the food pouch easier.", "An example of this embodiment is shown in FIG.", "9B, where the centerline 904 is offset, as emphasized by the arrows 906 and 908.The offset centerline also provides for an easier means to close the container 100 when a food pouch is installed.", "In some embodiments, the container 100 disclosed herein comprises handles.", "An example of this embodiment is shown in FIG.", "10.FIG.", "10A shows a perspective view of the container 100, showing the front portion 102 partially separated from the back portion 104, while FIG.", "10B shows a front view of this embodiment of the container 100.Handles 1002 allow the child to hold the container 100 while consuming the contents of the food pouch, without dropping the container.", "FIG.", "10A also illustrates another embodiment of a latch, which can be used with any of the embodiments of the container 100 disclosed herein.", "This embodiment comprises one or more latch mechanisms, each of which is an extension 1004 pointing towards the opposite portion of the container 100.For instance, if the extension 1004 is located on the front portion 102 of the container 100, as shown in FIG.", "10A, then the extension 1004 points towards the back portion 104, and vice versa.", "The extension 1004 comprises at least one raised member (also referred to as a lip) (not shown).", "The portion opposite to the one having the extension 1004, for example the back portion 104 if the extension is on the front portion 102, comprises one or more indents 1006.When the front portion 102 and the back portion 104 are brought together in the closed configuration, the raised member of the extension 1004 forms a friction lock with the indent 1006.In some embodiments, for example the one shown in FIG.", "10A, the raised member and the indent 1006 are circular.", "In other embodiments, they comprise a different cross section, for example a line, a rectangle, a square, a triangle, or another regular or irregular geometric shape.", "In some embodiments, the indent is on the extension 1004 and the raised member is on the opposite portion.", "The embodiment shown in FIG.", "10A does not have a surface 214.Instead only the side pinches 402 alone provide the necessary contour change to the food pouch.", "Thus, in some embodiments, the container 100 has a surface 214 without the side pinches 402, while in other embodiments, the container 100 has the side pinches 402 without a surface 214, and in still other embodiments, the container 100 has both the side pinches 402 and a surface 214.While the embodiment of FIG.", "10A shows a container 100 that has the handles 1002, the latch mechanism having extensions 1004 and indents 1006, and no surface 214, the skilled artisan recognizes that any of these features can be incorporated to any of the various embodiments of the container 100 disclosed herein.", "Thus, for example, the container 100 of FIGS.", "1, 5, 7, 8, 9, 11, or 12 can be made to have handles 1002, the latch mechanism having extensions 1004 and indents 1006, or no surface 214.And likewise, the embodiment of FIG.", "10 can be made with no handles 1002, a latch mechanism other than one having extensions 1004 and indents 1006, or a surface 214.FIGS.", "11A-D show another embodiment of the container 100 disclosed herein.", "In some embodiments, for example the one shown in FIG.", "11A, the front portion 102 is a cover, without having depth, and the back portion 104 comprises the entire depth of the container 100.In these embodiments, the food pouch is placed within the cavity of the back portion 104 and the front portion 102 closes shut to hold the food pouch within the container 100.The embodiment of FIG.", "11B shows latches 1104 that are external to the body of the container 100.In these embodiments, the downward distal end of the latch 1104 snaps on the reverse side of the back portion 104, resulting in securing the front portion 102 to the back portion 104.While this embodiment of a latch mechanism is disclosed in connection with the embodiment of FIG.", "11, it is understood that this latch mechanism can be used with any of the presently disclosed containers 100.The embodiment of FIG.", "11C is directed to a container 100 having a cap space 1106 at the bottom of the container 100.The cap space 1106 is a hollowed space into which the cap of the food pouch can be stored while the food pouch is opened for use.", "In some embodiments, for example that shown in FIG.", "11C, a nubbin 1108 is present at the center of the cap space 1106, onto which the cap is threaded or snapped for a more secure hold.", "As shown in FIG.", "11D, the cap space 1106 also causes a curved or raised surface 1110 to exist within the interior cavity of the container 100, for example similar to the curved top surface of the space 706, shown in FIG.", "7.In this embodiment, the interior of the back portion comprises only one interior cavity, the upper cavity 1112, similar to the upper cavity 216, above.", "The lower cavity is an exterior cavity and is the cap space 1106.Thus, in some embodiments, the surface divides the back portion into an upper cavity and a lower cavity, where the lower cavity is on the exterior.", "In some embodiments, for example the one shown in FIG.", "11A, the hinge 1102 around which the front portion 102 separates from the back portion 104 is located at a point away from an edge of the container 100.For example, in FIG.", "11A, the hinge 1102 is located approximately ⅕ of the way up from the bottom of the container 100.In certain embodiments, the hinge 1102 is located around the mid-section of the container 100.In certain embodiments, the hinge 202,1102 is on the side of the container 100.In these embodiments, the front portion 102 opens from the opposite side of the hinge 202,1102.In other embodiments, the hinge 202,1102 is on the back side.", "In some of these embodiments, when the front portion 102 separates from the back portion 104, the bottom of the container 100 will also rotate away.", "FIGS.", "12A-12C illustrate another embodiment of the container 100.In this embodiment, the front portion 102, shown in FIG.", "12B, has no depth.", "The entire depth of the container 100 is comprised in the back portion 104, shown in FIG.", "12C.", "The hinge 1202 comprises two components: the front component 1204 located at the bottom of the front portion 102, and the back component 1206 located at the bottom front of the back portion 104.Thus, unlike the hinge 202 of the embodiment of FIG.", "2, which is located in the middle area of the bottom of the container 100, when the container 100 is in its closed configuration, the hinge 1202 is located in the front of the bottom of the container 100, when the container 100 is in its closed configuration.", "A similar configuration can be applied to any of the containers 100 disclosed herein.", "The surface 1208 curves downward and traverses the entire width of the back portion 104.The surface 1208 divides the interior cavity of the back portion 104 into the upper cavity 1210 and the lower cavity 1212.Thus, while the surface 1208 acts similarly to the cantilever surface 214 of the embodiment of FIG.", "2, it is different in that the surface 1208 is connected to the sides of the back portion 104.In some embodiments, the lower cavity 1212 is filled and the interior cavity only comprises the upper cavity 1210.In other embodiments, the lower cavity 1212 is external.", "A similar configuration can be applied to any of the containers 100 disclosed herein.", "In the embodiment shown in FIG.", "12C, the top hole 206 is a semicircle defining an arc >180°.", "However, when the front portion 102 connects with the back portion 104 to close the container 100, the top hole 206 does not form a complete circle.", "Instead, the top hole 206 will comprise a straight edge formed by the front portion 102.This configuration makes it easier for a user to install the nozzle of the food pouch since the edge of the front portion 102 guides the nozzle into the semicircular part of the top hole 206.This configuration provides some of the advantages discussed above with respect to the embodiment shown in FIG.", "5B.", "A similar configuration can be applied to any of the containers 100 disclosed herein.", "The latch mechanism of the embodiment of FIG.", "12 comprises at least one extension 1214, having at least one raised member (or lip) 1216.In the embodiment shown in FIG.", "12, the extension 1214 is on the front portion 102, facing the back portion 104.Other configurations, as discussed above, for example, with the extension being on the side or on the back portion, are also contemplated.", "A corresponding indent (not shown) on the opposite portion, for example the back portion 104, creates a friction lock between the back portion 104 and the front portion 102.In some embodiments, the body of the container 100 comprises an outer shell and an inner shell, with a lining space therebetween.", "In some embodiments, the lining space is filled with air.", "Air is a known insulator.", "In these embodiments, the contents of food pouch retain their temperature for a longer period of time than if a single shell container is used.", "In other embodiments, the lining space is filled with a heatable and/or coolable fluid, for example a liquid or a gel.", "The user can heat the container, for example by placing the container in a microwave oven or warm water, thereby heating the fluid.", "In some embodiments, the fluid has a high specific heat, and therefore, loses its heat slowly.", "The heated fluid can then either heat the contents of the food pouch, or help in keeping the contents of a pre-heated food pouch warm.", "Similarly, if the fluid is coolable, or also coolable, the user can place the food pouch in a refrigerator, freezer, or cold water, thereby cooling the fluid.", "In some embodiments, the fluid has a high specific heat, and therefore, warms up slowly.", "The cooled fluid can then either cool the contents of the food pouch, or help in keeping the contents of a pre-cooled food pouch cool.", "In some embodiments, the fluid is freezable.", "While in some embodiments the food pouch is first inserted into the back portion 104 first and then the front portion 102 is latched to close the container 100, in other embodiments, the food pouch is first inserted into the front portion 102 first and then the back portion 104 is latched to close the container 100." ] ]
Patent_15876010
[ [ "Systems and Methods for Providing Convolutional Neural Network Based Image Synthesis Using Stable and Controllable Parametric Models, a Multiscale Synthesis Framework and Novel Network Architectures", "Systems and methods for providing convolutional neural network based image synthesis using localized loss functions is disclosed.", "A first image including desired content and a second image including a desired style are received.", "The images are analyzed to determine a local loss function.", "The first and second images are merged using the local loss function to generate an image that includes the desired content presented in the desired style.", "Similar processes can also be utilized to generate image hybrids and to perform on-model texture synthesis.", "In a number of embodiments, Condensed Feature Extraction Networks are also generated using a convolutional neural network previously trained to perform image classification, where the Condensed Feature Extraction Networks approximates intermediate neural activations of the convolutional neural network utilized during training." ], [ "1.A system for generating a synthesized image including desired content presented in a desired style comprising: one or more processors; memory readable by the one or more processors; and instructions stored in the memory that when read by the one or more processors direct the one or more processors to: receive a source content image that includes desired content for a synthesized image, receive a source style image that includes a desired texture for the synthesized image, determine a localized loss function for a pixel in at least one of the source content image and the source style image, and generate the synthesized image by: optimizing a value of a pixel in the synthesized image to a content loss function of a corresponding pixel in the content source image and a style loss function of a corresponding pixel in the source style image wherein at least one of the corresponding pixels is the pixel that has a determined localized loss function and one of the content loss function and the source loss function is the determined localized loss function." ], [ "<SOH> BACKGROUND <EOH>With the growth and development of creative projects in a variety of digital spaces (including, but not limited to, virtual reality, digital art, as well as various industrial applications), the ability to create and design new works based on the combination of various existing sources has become an area of interest.", "However, the actual synthesis of such sources is a hard problem that raises a variety of difficulties." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>Systems and methods for providing convolutional neural network based image synthesis are disclosed.", "In many embodiments, processes for providing CNN-based image synthesis may be performed by a server system.", "In accordance with several embodiments, the processes may be performed by a “cloud” server system.", "In still further embodiments, the processes may be performed on a user device.", "One embodiment is a system for generating a synthesized image including desired content presented in a desired style includes one or more processors, memory readable by the one or more processors.", "The system in accordance with some embodiments of the invention includes instructions stored in the memory that when read by the one or more processors direct the one or more processors to receive a source content image that includes desired content for a synthesized image, receive a source style image that includes a desired texture for the synthesized image, determine a localized loss function for a pixel in at least one of the source content image and the source style image, and generate the synthesized image by optimizing a value of a pixel in the synthesized image to a content loss function of a corresponding pixel in the content source image and a style loss function of a corresponding pixel in the source style image wherein at least one of the corresponding pixels is the pixel that has a determined localized loss function and one of the content loss function and the source loss function is the determined localized loss function.", "In another embodiment, the localized loss function is represented by a Gram matrix.", "In a further embodiment, the localized loss function is represented by a covariance matrix.", "In still another embodiment, the localized loss function is determined using a Convolutional Neural Network (CNN).", "In a still further embodiment, the optimizing is performed by back propagation through the CNN.", "In yet another embodiment, the localized loss function is determined for a pixel in the source style image.", "In a yet further embodiment, the instructions to determine a localized loss function for a pixel in the source style image direct the one or more processors to receive a mask that identifies regions of the style source image, determine a group of pixels including the pixel that are included in one of the plurality of regions identified by the mask, determine a localized loss function for the one of the plurality of regions from the groups of pixels included in the one of the plurality of regions, and associate the localized loss function with the pixel.", "In another additional embodiment, the instructions to determine a localized loss function for a pixel in the source style image direct the one or more processors to group the pixels of the source style image into a plurality of cells determined by a grid applied to the source style image, determine a localized loss function for the one of the plurality of cells that has a group of pixels that include the pixel, and associate the determined localized loss function of the one of the plurality of cells with the pixel.", "In a further additional embodiment, the instructions to determine a localized loss function for a pixel in the source style image direct the one or more processors to determine a group of neighbor pixels for a pixel in the source content image, determine a group of corresponding pixels in the source style image associated with the group of neighbor pixels in the source content image wherein each of the group of corresponding pixels corresponds to one of the group of neighbor pixels and includes the pixel, and determine a local loss function for the group of corresponding pixels.", "In another embodiment again, the localized loss function is determined for a pixel in the source content image.", "In a further embodiment again, the instructions to determine a localized loss function for a pixel in the source content image direct the one or more processors to receive a mask that identifies regions of the source content image, determine a group of pixels including the pixel that are included in one of the plurality of regions identified by the mask, determine a localized loss function for the one of the plurality of regions from the groups of pixels included in the one of the plurality of regions, and associate the localized loss function with the pixel.", "In still yet another embodiment, the instructions to determine a localized loss function for a pixel in the source style image direct the one or more processors to group the pixels of the source content image into a plurality of cells determined by a grid applied to the source style image, determine a localized loss function for the one of the plurality of cells that has a group of pixels that include the pixel, and associate the determined localized loss function of the one of the plurality of cells with the pixel.", "In a still yet further embodiment, the instructions to determine a localized loss function for a pixel in the source style image direct the one or more processors to determine a global content loss function for the source content image from the pixels of the source content image, determine a weight for the pixel indicating a contribution to a structure in the source content image, and apply the weight to the global content loss function to determine the localized loss function for the pixel.", "In still another additional embodiment, the weight is determined based upon a Laplacian pyramid of black and white versions of the source content image.", "In a still further additional embodiment, a localized loss function is determined for a pixel in the source content image and a corresponding pixel in the source style image.", "In still another embodiment again, the optimization uses the localized loss function for the pixel in the source content image as the content loss function and the localized loss function of the pixel in the source style image as the style loss function.", "In a still further embodiment again, pixels in the synthesized image begin as white noise.", "In yet another additional embodiment, each pixel in the synthesized image begins with a value equal to a pixel value of a corresponding pixel in the source content image.", "In a yet further additional embodiment, the optimizing is performed to minimize to a loss function that includes the content loss function, a style loss function, and a histogram loss function.", "In yet another embodiment again, a method for performing style transfer in an image synthesis system where a synthesized image is generated with content from a source content image and texture from a source style image includes receiving a source content image that includes desired content for a synthesized image in the image synthesis system, receiving a source style image that includes a desired texture for the synthesized image in the image synthesis system, determining a localized loss function a pixel in at least one of the source content image and the source style image using the image synthesis system, and generating the synthesized image using the image synthesis system by optimizing a value of a pixel in the synthesized image to a content loss function of a corresponding pixel in the content source image and a style loss function of a corresponding pixel in the source style image wherein at least one of the corresponding pixels is the pixel that has a determined localized loss function and one of the content loss function and the source loss function is the determined localized loss function.", "In a yet further embodiment again, the localized loss function is represented by a Gram matrix.", "In another additional embodiment again, the determining of a localized loss function for a pixel in the source style image includes receiving a mask that identifies regions of the style source image in the image synthesis system, determining a group of pixels including the pixel that are included in one of the plurality of regions identified by the mask using the image synthesis system, determining a localized loss function for the one of the plurality of regions from the groups of pixels included in the one of the plurality of regions using the image synthesis system, and associating the localized loss function with the pixel using the image synthesis system.", "In a further additional embodiment again, the determining a localized loss function for a pixel in the source style image comprises grouping the pixels of the source style image into a plurality of cells determined by a grid applied to the source style image using the image synthesis system, determining a localized loss function for the one of the plurality of cells that has a group of pixels that include the pixel using the image synthesis system, and associating the determined localized loss function of the one of the plurality of cells with the pixel using the image synthesis system.", "In still yet another additional embodiment, determining of a localized loss function for a pixel in the source style image includes determining a group of neighbor pixels for a pixel in the source content image using the image synthesis system, determining a group of corresponding pixels in the source style image associated with the group of neighbor pixels in the source content image wherein each of the group of corresponding pixels corresponds to one of the group of neighbor pixels and includes the pixel using the image synthesis system, and determining a local loss function for the group of corresponding pixels using the image synthesis system.", "Additional embodiments and features are set forth in part in the description that follows, and in part will become apparent to those skilled in the art upon examination of the specification or may be learned by the practice of the invention.", "A further understanding of the nature and advantages of the present invention may be realized by reference to the remaining portions of the specification and the drawings, which forms a part of this disclosure." ], [ "CROSS REFERENCED APPLICATION This application is a continuation of U.S. patent application Ser.", "No.", "15/694,677, filed Sep. 1, 2017 and claims priority to U.S.", "Provisional Application Ser.", "No.", "62/383,283, filed Sep. 2, 2016, U.S.", "Provisional Application Ser.", "No.", "62/451,580, filed Jan. 27, 2017, and U.S.", "Provisional Application Ser.", "No.", "62/531,778, filed Jul.", "12, 2017.The contents of each of these applications are hereby incorporated by reference as if set forth herewith.", "FIELD OF THE INVENTION This invention generally relates to image synthesis and more specifically relates to image synthesis using convolutional neural networks based upon exemplar images.", "BACKGROUND With the growth and development of creative projects in a variety of digital spaces (including, but not limited to, virtual reality, digital art, as well as various industrial applications), the ability to create and design new works based on the combination of various existing sources has become an area of interest.", "However, the actual synthesis of such sources is a hard problem that raises a variety of difficulties.", "SUMMARY OF THE INVENTION Systems and methods for providing convolutional neural network based image synthesis are disclosed.", "In many embodiments, processes for providing CNN-based image synthesis may be performed by a server system.", "In accordance with several embodiments, the processes may be performed by a “cloud” server system.", "In still further embodiments, the processes may be performed on a user device.", "One embodiment is a system for generating a synthesized image including desired content presented in a desired style includes one or more processors, memory readable by the one or more processors.", "The system in accordance with some embodiments of the invention includes instructions stored in the memory that when read by the one or more processors direct the one or more processors to receive a source content image that includes desired content for a synthesized image, receive a source style image that includes a desired texture for the synthesized image, determine a localized loss function for a pixel in at least one of the source content image and the source style image, and generate the synthesized image by optimizing a value of a pixel in the synthesized image to a content loss function of a corresponding pixel in the content source image and a style loss function of a corresponding pixel in the source style image wherein at least one of the corresponding pixels is the pixel that has a determined localized loss function and one of the content loss function and the source loss function is the determined localized loss function.", "In another embodiment, the localized loss function is represented by a Gram matrix.", "In a further embodiment, the localized loss function is represented by a covariance matrix.", "In still another embodiment, the localized loss function is determined using a Convolutional Neural Network (CNN).", "In a still further embodiment, the optimizing is performed by back propagation through the CNN.", "In yet another embodiment, the localized loss function is determined for a pixel in the source style image.", "In a yet further embodiment, the instructions to determine a localized loss function for a pixel in the source style image direct the one or more processors to receive a mask that identifies regions of the style source image, determine a group of pixels including the pixel that are included in one of the plurality of regions identified by the mask, determine a localized loss function for the one of the plurality of regions from the groups of pixels included in the one of the plurality of regions, and associate the localized loss function with the pixel.", "In another additional embodiment, the instructions to determine a localized loss function for a pixel in the source style image direct the one or more processors to group the pixels of the source style image into a plurality of cells determined by a grid applied to the source style image, determine a localized loss function for the one of the plurality of cells that has a group of pixels that include the pixel, and associate the determined localized loss function of the one of the plurality of cells with the pixel.", "In a further additional embodiment, the instructions to determine a localized loss function for a pixel in the source style image direct the one or more processors to determine a group of neighbor pixels for a pixel in the source content image, determine a group of corresponding pixels in the source style image associated with the group of neighbor pixels in the source content image wherein each of the group of corresponding pixels corresponds to one of the group of neighbor pixels and includes the pixel, and determine a local loss function for the group of corresponding pixels.", "In another embodiment again, the localized loss function is determined for a pixel in the source content image.", "In a further embodiment again, the instructions to determine a localized loss function for a pixel in the source content image direct the one or more processors to receive a mask that identifies regions of the source content image, determine a group of pixels including the pixel that are included in one of the plurality of regions identified by the mask, determine a localized loss function for the one of the plurality of regions from the groups of pixels included in the one of the plurality of regions, and associate the localized loss function with the pixel.", "In still yet another embodiment, the instructions to determine a localized loss function for a pixel in the source style image direct the one or more processors to group the pixels of the source content image into a plurality of cells determined by a grid applied to the source style image, determine a localized loss function for the one of the plurality of cells that has a group of pixels that include the pixel, and associate the determined localized loss function of the one of the plurality of cells with the pixel.", "In a still yet further embodiment, the instructions to determine a localized loss function for a pixel in the source style image direct the one or more processors to determine a global content loss function for the source content image from the pixels of the source content image, determine a weight for the pixel indicating a contribution to a structure in the source content image, and apply the weight to the global content loss function to determine the localized loss function for the pixel.", "In still another additional embodiment, the weight is determined based upon a Laplacian pyramid of black and white versions of the source content image.", "In a still further additional embodiment, a localized loss function is determined for a pixel in the source content image and a corresponding pixel in the source style image.", "In still another embodiment again, the optimization uses the localized loss function for the pixel in the source content image as the content loss function and the localized loss function of the pixel in the source style image as the style loss function.", "In a still further embodiment again, pixels in the synthesized image begin as white noise.", "In yet another additional embodiment, each pixel in the synthesized image begins with a value equal to a pixel value of a corresponding pixel in the source content image.", "In a yet further additional embodiment, the optimizing is performed to minimize to a loss function that includes the content loss function, a style loss function, and a histogram loss function.", "In yet another embodiment again, a method for performing style transfer in an image synthesis system where a synthesized image is generated with content from a source content image and texture from a source style image includes receiving a source content image that includes desired content for a synthesized image in the image synthesis system, receiving a source style image that includes a desired texture for the synthesized image in the image synthesis system, determining a localized loss function a pixel in at least one of the source content image and the source style image using the image synthesis system, and generating the synthesized image using the image synthesis system by optimizing a value of a pixel in the synthesized image to a content loss function of a corresponding pixel in the content source image and a style loss function of a corresponding pixel in the source style image wherein at least one of the corresponding pixels is the pixel that has a determined localized loss function and one of the content loss function and the source loss function is the determined localized loss function.", "In a yet further embodiment again, the localized loss function is represented by a Gram matrix.", "In another additional embodiment again, the determining of a localized loss function for a pixel in the source style image includes receiving a mask that identifies regions of the style source image in the image synthesis system, determining a group of pixels including the pixel that are included in one of the plurality of regions identified by the mask using the image synthesis system, determining a localized loss function for the one of the plurality of regions from the groups of pixels included in the one of the plurality of regions using the image synthesis system, and associating the localized loss function with the pixel using the image synthesis system.", "In a further additional embodiment again, the determining a localized loss function for a pixel in the source style image comprises grouping the pixels of the source style image into a plurality of cells determined by a grid applied to the source style image using the image synthesis system, determining a localized loss function for the one of the plurality of cells that has a group of pixels that include the pixel using the image synthesis system, and associating the determined localized loss function of the one of the plurality of cells with the pixel using the image synthesis system.", "In still yet another additional embodiment, determining of a localized loss function for a pixel in the source style image includes determining a group of neighbor pixels for a pixel in the source content image using the image synthesis system, determining a group of corresponding pixels in the source style image associated with the group of neighbor pixels in the source content image wherein each of the group of corresponding pixels corresponds to one of the group of neighbor pixels and includes the pixel using the image synthesis system, and determining a local loss function for the group of corresponding pixels using the image synthesis system.", "Additional embodiments and features are set forth in part in the description that follows, and in part will become apparent to those skilled in the art upon examination of the specification or may be learned by the practice of the invention.", "A further understanding of the nature and advantages of the present invention may be realized by reference to the remaining portions of the specification and the drawings, which forms a part of this disclosure.", "BRIEF DESCRIPTION OF THE DRAWINGS The patent or application file contains at least one drawing executed in color.", "Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.", "The description and claims will be more fully understood with reference to the following figures and data graphs, which are presented as exemplary embodiments of the invention and should not be construed as a complete recitation of the scope of the invention.", "FIG.", "1 is an illustration of various devices that may perform one or more processes to provide Convolutional Neural Network (CNN) based image synthesis in accordance with an embodiment of the invention.", "FIG.", "2 is an illustration of components of a processing system in a device that executes one or more processes to provide CNN-based image synthesis using localized loss functions in accordance with an embodiment of the invention.", "FIG.", "3 is an illustration of images showing the instability in a Gram matrix.", "FIG.", "4 is an illustration of images showing a comparison of results of texture synthesis performed in accordance with various embodiments of the invention with and without the use of pyramids.", "FIG.", "5 is an illustration of a flow diagram of a process for providing CNN-based image synthesis that performs style transfer using localized loss functions in accordance with an embodiment of the invention.", "FIG.", "6 is an illustration of two input images and a resulting image from a style transfer process of the two input images using localized style loss functions in accordance with an embodiment of the invention.", "FIG.", "7 is an illustration of a flow diagram of a process for generating region-based loss functions in accordance with an embodiment of the invention.", "FIG.", "8 is an illustration of conceptual images showing masks of regions for two input images used in a style transfer process using region-based loss functions in accordance with an embodiment of the invention.", "FIG.", "9 is an illustration of conceptual images of cells in two input images in a style transfer process using uniform regions in accordance with an embodiment of the invention.", "FIG.", "10 is an illustration of a flow diagram of a process for generating localized loss functions in a style transfer process using uniform regions in accordance with an embodiment of the invention.", "FIG.", "11 is an illustration of a comparison of similar cells in two input images in a style transfer process using uniform regions in accordance with an embodiment of the invention.", "FIG.", "12 is an illustration of a comparison of similar pixels in two input images in a style transfer process using a per pixel loss transfer in accordance with an embodiment of the invention.", "FIG.", "13 is an illustration of a process for generating localized style loss functions for a style transfer process using per pixel loss transfer in accordance with an embodiment of the invention.", "FIG.", "14 is an illustration of two input images that provide an example of the operation of a style transfer process using a global content loss function in accordance with an embodiment of the invention.", "FIG.", "15 is an illustration of a resulting image from the style transfer from the two input images of FIG.", "14 performed by a style transfer process using global content loss in accordance with an embodiment of the invention.", "FIG.", "16 is an illustration of a Laplacian Pyramid of images derived from a content source image from FIG.", "14 used in a style transfer process using local content loss in accordance with an embodiment of the invention.", "FIGS.", "17 and 18 are illustrations of images produced by style transfer processes using global loss functions in accordance with certain embodiments of this invention.", "FIG.", "19 is an illustration of images generated by a style transfer process using localized content loss functions in accordance with an embodiment of the invention.", "FIG.", "20 is an illustration of a flow diagram of a process for determining localized loss using masks in accordance with an embodiment of the invention.", "FIG.", "21 is an illustration of images synthesized in accordance with some embodiments of the invention and images generated using other processes.", "FIG.", "22 is an illustration of images of masks used in an aging process in accordance with an embodiment of the invention.", "FIG.", "23 is an illustration of a synthesis order in a multiscale pyramid framework in accordance with an embodiment of the invention.", "FIG.", "24 is an illustration of a textured mapped model and components used to form the textured mapped model using a filter process in accordance with an embodiment of the invention.", "FIG.", "25 is an illustration of a texture and the texture applied to a surface of a mesh by a filter process in accordance with an embodiment of the invention.", "DETAILED DISCUSSION Turning now to the drawings, systems and methods for providing Convolutional Neural Network (CNN) based image synthesis in accordance with some embodiments of the invention are described.", "In many embodiments, processes for providing CNN-based image synthesis may be performed by a server system.", "In accordance with several embodiments, the processes may be performed by a “cloud” server system.", "In still further embodiments, the processes may be performed on a user device.", "In accordance with many embodiments, the loss functions may be modeled using Gram matrices.", "In a number of embodiments, the loss functions may be modeled using covariance matrices.", "In accordance with several embodiments, the total loss may further include mean activation or histogram loss.", "In accordance with sundry embodiments, a source content image, including desired structures for a synthesized image and a source style image, including a desired texture for the synthesized image, are received.", "A CNN may be used to determine localized loss functions for groups of pixels in the source content and/or source style images.", "The localized content and/or localized style loss functions may be used to generate a synthesized image that includes the content from the source content image and the texture from the source style image.", "In accordance with many embodiments, an optimization process may be performed to optimize pixels in a synthesized image using the localized content loss function of a corresponding pixel from the source content image and/or the localized style loss function of a corresponding pixel from the source style image.", "In accordance with a number of embodiments, the optimization may be an iterative optimization that is performed by back propagation through a CNN, or through a purely feed-forward process.", "In a number of embodiments, a specific pyramid-stack hybrid CNN architecture based on some combination of pooling, strided convolution and dilated convolution is used for image synthesis.", "As can readily be appreciated, the specific CNN architecture utilized in image synthesis is largely dependent upon the requirements of a given application.", "In accordance with certain embodiments, the CNN-based image synthesis processes may perform aging of an image.", "In accordance with many embodiments, CNN-based image synthesis processes may be used to perform continuous weathering by continually modifying the parametric model.", "In accordance with a number of embodiments, the CNN-based image synthesis processes may be used to perform weathering by controlling the weathering through a “painting by numbers” process.", "In accordance with several embodiments, CNN-based image synthesis processes may be used to perform continuous multiscale aging.", "In accordance with many embodiments, CNN-based image synthesis processes may be used to perform aging by transferring weathering patterns from external exemplars.", "In accordance with sundry embodiments, CNN-based image synthesis processes may combine optimization and feedforward parametric texture synthesis for fast high-resolution synthesis.", "In accordance with many embodiments, CNN-based image synthesis processes may be used to perform super image super resolution (SISR) for rending.", "In accordance with a number of embodiments, CNN-based image synthesis processes may combine parametric and non-parametric-non-CNN synthesis within a pyramid framework.", "In several embodiments, dilated convolution neural networks can be utilized to synthesize image hybrids.", "Image hybridization involves starting from a set of several source images within a category and mixing them together in a way that produces a new member of that category.", "In a number of embodiments, image hybridization is performed using either an optimization or feedforward based synthesis strategy.", "In either case, a key aspect of the image hybridization is to generate new activations at different levels of the network which combine the activation features extracted from the input images into new hybrid configurations.", "Processes in accordance with many embodiments of the invention integrate an on-model synthesis approach into the CNN approach.", "The goal of processes in accordance with some embodiments of the invention is to provide an on-model texture synthesis scheme that allows the user to supply a fully textured model as the input exemplar instead of just a texture, and apply that texture from the model onto a different untextured model.", "In many embodiments, the processes produce textures that conform to geometric shapes and the feature contents of that texture are guided by the underlying shape itself.", "This results in image synthesis that can be applied on top of already textured meshes, and can also produce appearance transfer from one textured mesh onto another.", "In a number of embodiments, a specific class of artificial neural networks that can be referred to as Condensed Feature Extraction Networks are generated from CNNs trained to perform image classification.", "Systems and methods in accordance with many embodiments of the invention generate Condensed Feature Extraction Networks by utilizing an artificial neural network with a specific number of neurons to learn a network that approximates the intermediate neural activations of a different network with a larger number (or the same number) of artificial neurons.", "In several embodiments, the artificial neural network that is utilized to train a Condensed Feature Extraction Network is a CNN.", "In certain embodiments, the computation required to generate outputs from the Condensed Feature Extraction Network for a set of input images is reduced relative to the CNN used to train the Condensed Feature Extraction Networks.", "Systems and methods for providing CNN-based image synthesis are described in more detail below.", "Systems for Providing Convolutional Neural Network Based Image Synthesis A system that provides CNN-based image synthesis in accordance with some embodiments of the invention is shown in FIG.", "1.Network 100 includes a communications network 160.The communications network 160 is a network such as the Internet that allows devices connected to the network 160 to communicate with other connected devices.", "Server systems 110, 140, and 170 are connected to the network 160.Each of the server systems 110, 140, and 170 may be a group of one or more server computer systems communicatively connected to one another via internal networks that execute processes that provide cloud services to users over the network 160.For purposes of this discussion, cloud services are one or more applications that are executed by one or more server systems to provide data and/or executable applications to devices over a network.", "The server systems 110, 140, and 170 are shown each having three servers in the internal network.", "However, the server systems 110, 140 and 170 may include any number of servers and any additional number of server systems may be connected to the network 160 to provide cloud services including (but not limited to) virtualized server systems.", "In accordance with various embodiments of this invention, processes for providing CNN-based image synthesis processes and/or systems may be provided by one or more software applications executing on a single server system and/or a group of server systems communicating over network 160.Users may use personal devices 180 and 120 that connect to the network 160 to perform processes for providing CNN-based image synthesis in accordance with various embodiments of the invention.", "In the illustrated embodiment, the personal devices 180 are shown as desktop computers that are connected via a conventional “wired” connection to the network 160.However, the personal device 180 may be a desktop computer, a laptop computer, a smart television, an entertainment gaming console, or any other device that connects to the network 160 via a “wired” or “wireless” network connection.", "The mobile device 120 connects to network 160 using a wireless connection.", "A wireless connection is a connection that may use Radio Frequency (RF) signals, Infrared (IR) signals, or any other form of wireless signaling to connect to the network 160.In FIG.", "1, the mobile device 120 is a mobile telephone.", "However, mobile device 120 may be a mobile phone, a Personal Digital Assistant (PDA), a tablet, a smartphone, or any other type of device that connects to network 160 via wireless connection in accordance with various other embodiments of the invention.", "In accordance with some embodiments of the invention, the processes for providing CNN-based image synthesis may be performed by the user device.", "In several other embodiments, an application being executed by the user device may capture or obtain the two or more input images and transmit the captured image(s) to a server system that performs the processes for providing CNN-based image synthesis.", "In accordance with a number of embodiments where one or more of the images is captured by the user device, the user device may include a camera or some other image capture system that captures the image.", "The specific computing system(s) used to capture images and/or processing images to perform CNN-based image synthesis often is largely dependent upon the requirements of a given application and should not be considered as limited to any specific computing system(s) implementation(s).", "Computing systems and processes for performing CNN based image synthesis are discussed further below.", "Example of Processing Systems An example of a processing system in a device that executes instructions to perform processes that provide CNN-based image synthesis in accordance with an embodiment of the invention is shown in FIG.", "2.One may recognize that a particular processing system may include other components that are omitted for brevity without departing from various embodiments of the invention.", "The processing device 200 includes a processor 205, a non-volatile memory 210, and a volatile memory 215.The processor 205 may be a processor, microprocessor, controller or a combination of processors, microprocessors and/or controllers that perform instructions stored in the volatile memory 215 and/or the non-volatile memory 210 to manipulate data stored in the memory.", "The non-volatile memory 210 can store the processor instructions utilized to configure the processing system 200 to perform processes including processes in accordance with particular embodiments of the invention and/or data for the processes being utilized.", "In accordance with some embodiments, the processing system software and/or firmware can be stored in any of a variety of non-transient computer readable media appropriate to a specific application.", "A network interface is a device that allows processing system 200 to transmit and receive data over a network based upon the instructions performed by processor 205.Although an example of processing system 200 is illustrated in FIG.", "2, any of a variety of processing systems in the various devices may be configured to provide the methods and systems in accordance with various embodiments of the invention.", "Convolutional Neural Network Based Image Synthesis CNNs can be powerful tools for synthesizing similar but different version of an image or transferring the style of one image onto the content of another image.", "Recently, compelling results have been achieved through parametric modeling of the image statistics using a deep CNN.", "An example CNN used for image style transfer is described by Leon Gatys in a paper entitled, “Image Style Transfer Using Convolutional Neural Networks” that may be obtained at www.cv-foundation.org/openacess/content_cvpr_2016/papers/Gatys_Image_Style_Transfer_CV PR_2016_paper.pdf.", "In particular, CNN-based image synthesis processes are particularly suited for performing texture synthesis and style transfer.", "In particular, CNN-based image synthesis systems may perform texture synthesis in the following manner: A CNN image synthesis system receives an input source texture, S, and synthesizes an output texture, O.", "S and O are passed through a CNN such as VGG that generates feature maps for the activations of the first L convolutional layers of the CNN.", "For purposes of this discussion, the activations of the first L convolutional layers are denoted as S1 .", ".", ".", "SL and O1 .", ".", ".", "OL.", "A loss gram over the layers, which preserves some properties of the input texture by means of a Gram matrix can be expressed as: ℒ gram = ∑ l = 1 L  α l  S l  2   G  ( S l ) - G  ( O l ) )  F 2 ( 1 ) where Al are user parameters that weight terms in the loss, |⋅| is the number of elements in a tensor, F is the Frobenius norm, and the Gram matrix G(F) is defined over any feature map F as an Nl×Nl matrix of inner products between pairs of features: G ij  ( F ) = ∑ k  F ik  F jk ( 2 ) Fi,j refers to feature i's pixel j within the feature map.", "The synthesized output image O is initialized with white noise and is then optimized by applying gradient descent to equation (1).", "Specifically, the gradient of equation (1) with respect to the output image O is computed via backpropagation.", "CNN-based image synthesis processes that perform style transfer synthesis operate in a similar manner to the texture synthesis process described above.", "However, a CNN-based image synthesis system receives a content image, C, and a style image, S, that are used to generate a styled image, O.", "All three images are passed through a CNN, such as a VGG, that gives activations for the first L convolutional layers denoted as C1 .", ".", ".", "CL, S1 .", ".", ".", "SL, O1 .", ".", ".", "Ol.", "The total style transfer loss combines the losses for the style image (ζgram) and the content image (ζcontent): transfer=gram+content (3) The content loss is a feature distance between content and output that attempts to make output and content look similar: ℒ content = ∑ l = 1 L  β l  C l    C l - O l  F 2 ( 4 ) Where βl are user weight parameters, the output image O is initialized with white noise and optimized using a gradient descent.", "As such, CNN-based image synthesis processes performing style transfer may use an iterative optimization process to cause the white noise image of the synthesized image to incrementally begin to resemble some user-specified combination of the source content and style images.", "In accordance with many embodiments of the invention, a CNN backpropagation training procedure may be used as the iterative optimization process to turn the white noise or content image into an image that combines features of the content and style images.", "During backpropagation training procedures performed in accordance with a number of embodiments, the iterative optimization process can be directed by a loss function (equation 4) that the backpropagation training procedure is trying to minimize.", "In accordance with several embodiments, the loss function is calculated as the difference between parametric models encoding the style of a style image and the image being synthesized.", "In addition, in some embodiments of this invention, a content loss can be included as well, where the content loss is some distance metric between raw neural activations calculated for the content image and the image being synthesized.", "If a style loss is used without a content loss and the image being synthesized starts from noise, then the resulting operation is texture synthesis.", "If a style loss is used without content loss and the image being synthesized starts from the content image, then the resulting operation is style transfer.", "If both style and content loss are used then the operation will always be style transfer.", "In accordance with various other embodiments of the invention, other image processing applications including, but not limited to, image hybridization, super-resolution upscaling and time-varying weathering, could be achieved using the same CNN framework but using different loss functions.", "CNN-based image synthesis processes in accordance with certain embodiments of the invention may use loss functions to direct the optimization process in various synthesis processes that may be performed.", "However, CNN-based image synthesis processes in accordance with particular embodiments of this invention use a collection of stable loss functions for the CNN-based image synthesis to achieve various results.", "In accordance with some embodiments, CNN-based image synthesis processes use multiple stable loss functions for texture synthesis and style transfer.", "Thus, multiple stable loss functions for the style transfer including loss functions for the style and content are addressed separately below.", "Problems with the Use of Gram Matrices A problem that can be experienced when using Gram matrices as loss functions in style transfer is that the results are often unstable.", "The cause of the instability is illustrated in FIG.", "3.In FIG.", "3, an input image 301 has a uniform distribution of intensities with a mean of μ1=½ ≈0.707 and a standard deviation of σ1=0.An output image 302 has a non-uniform distribution with a mean of μ2=½ and a standard deviation of σ2=½.", "If interpreted as the activation of a feature map with one feature, these two distributions have equivalent non-central second moments of ½, and equal Gram matrices.", "The problem is that there are many distributions that result in an equivalent Gram matrix.", "However, the Gram matrices do not match image intensities.", "Instead, Gram matrices match feature activations, i.e.", "feature maps, after applying the activation functions but the same argument applies: activation maps with quite different means and variances can still have the same Gram matrix.", "The problem arises because a Gram matrix is statistically related to neither the mean nor covariance matrices.", "Instead, a Gram matrix is related to a matrix of non-central second moments.", "To show this, a feature activation map, F, with m features, is used as an example.", "For brevity, “feature map activations” are simply referred to as “features,” such that a “feature” refers to the result of applying an activation function.", "The statistics of the features in the feature map F can be summarized by using an m dimensional random variable X to model the probability distribution of a given m-tuple of features.", "The random vector of features X can be related to the feature map F. For example, the Gram matrix, G(F), may be normalized by the number of samples n to obtain a sample estimator for the second non-central mixed moments E[XXT].", "As such, the terms (normalized) “Gram matrix” and E[XXT] may be used interchangeably in the following discussion even though one is actually a sampled estimator of the other.", "In the following argument, 1 n  G  ( F ) = E  [ XX T ] and the mean feature is defined as μ=E[X].", "By a general property of covariance matrices, Σ(X)=E[XXT]−μμT, Σ indicates a covariance matrix.", "After rearranging, the following equation results: E[XXT]=Σ(X)+μμT (5) In the case where there is only one feature, m=1, equation (5) becomes: 1 n  G  ( F ) = E  [ X 2 ] = σ 2 + μ 2 =  ( σ , μ )  2 ( 6 ) Where σ is the standard deviation of feature X.", "For a feature map, F1 for the input source image, and a feature map, F2, for the synthesized output image that have respective feature distributions X1, X2, means μ1, μ2, and standard deviations σ1, σ2, the features maps will have the same Gram matrix if the following condition for equation (6) holds: ∥(σ1,μ1)∥=∥(σ2,μ2)∥ (7) As such, an infinite number of 1D feature maps with different variances but equal Gram matrices may be created.", "This is not optimal for image synthesis.", "Specifically, this means that even if a Gram matrix is held constant, the variance ρ22 of the synthesized texture map can freely change (with corresponding changes to the mean, μ2, based on equation (7)).", "Conversely, the mean, μ2, of the synthesized texture map can freely change (with corresponding changes to the variance, σ22).", "This property often leads to the instabilities.", "For simplicity, it can be assumed that a CNN may be flexible enough to generate any distribution of output image features.", "To generate an output texture with a different variance (e.g.", "σ2»σ1) but equal Gram matrix, equation (6) can be solved for μ2 to obtain μ1=√{square root over (σ12+μ12−σ22)}.", "This is shown in FIG.", "3 where the distribution X1 of the image 301 has μ 1 = 1 2 and σ1=0 and the image 302 has larger standard deviation of σ2=½.", "In the multidimensional case where m>1, if there is no correlation between features, the m separate cases of the previous 1D scenario.", "Thus, while maintaining the same Gram matrix, all of the variances can be changed, as long as a corresponding change to the mean is made.", "This can lead to instabilities in variance or mean.", "However, in the multidimensional scenario, typically there are correlations between features.", "The following example illustrates this point.", "In this example, an input feature map F1, has an input feature random vector X1, a mean μ, and covariance matrix Σ(X1).", "To generate a set of output feature random vectors X2 with an equal Gram matrix but different variance, an affine transformation is applied to the input random feature vector X1 to obtain a transformed random vector of output features activation X2=AX1+b, where A is an m×m matrix, and b is an m vector.", "The Gram matrices X1 and X2 are set equal to one another using equation (5) above to obtain: E[X2X2T]=AΣ(X1)AT+(Aμ+b)(Aμ+b)T=E[X1X1T]=Σ(X1)+μμT.", "(8) The variances of the output random feature activation vector X2 may be constrained along the main diagonal of its covariance matrix so that the variances are equal to a set of “target” output image feature activation variances.", "The remains may be an unknown variable in the transformation matrix A, and vector b may be determined using closed form solutions of the resulting quadratic equations.", "However, these equations are often long and computationally intensive to solve.", "Yet, it does show that there are more unknowns than equations.", "Thus, it is possible to generate an output distribution X2 with different variances that the input feature distribution X1, but with the same Gram matrix.", "Specifically, there are m(m+3)/2 constraints due to equation (8) (there are m(m+1)/2 constraints due to the upper half of the symmetric matrix, plus m constraints for the known output feature variances).", "Covariance and Mean Loss In accordance with sundry embodiments of the invention, due to the Gram matrix stability issues identified above, CNN-based image synthesis processes use a covariance matrix instead of a Gram matrix to guide the synthesis process.", "Covariance matrices are similar to Gram matrices but do not share the same limitation.", "By subtracting off the mean activation before computing inner products, covariance matrices explicitly preserve statistical moments of various orders in the parametric model.", "By this we explicitly refer to the mean of all feature vectors as the first order moment and to the co-activations of feature vectors centered around their mean as second order moments.", "Replacing Gram matrices with Covariance matrices can stabilize the synthesis process for some textures, however, subtracting the mean can affect the desired features to be reproduced during the synthesis process in undesirable ways.", "To counteract this effect, we introduce an additional loss term for mean activations.", "This new parametric model allows the covariance loss and means loss to drive the synthesis.", "This can make the combined loss for texture synthesis: Ltexture=Lcovariance+Lmean+Ltv (12) The replacement of the Gram matrix with a Covariance matrix may improve but does not decisively solve the stability issues inherent in texture synthesis and/or style transfer.", "However, the covariance matrix may be a powerful method for describing image style in a stable form when the texture being parameterized is highly stochastic and can be represented as a single cluster in feature space.", "It may still be a problem that many textures and most natural images contain multiple clusters.", "In other words, these textures or natural images contain a combination of multiple distinct textures.", "When an input texture exhibits multiple feature space clusters and the cluster centers are far apart from each other, a covariance matrix may exhibit the same unstable behavior as a Gram matrix.", "The reason for the unstable behavior is that the center between multiple clusters ensures that every cluster will be un-centered and, thus, will not exhibit stable mathematical properties.", "Although CNN-based image synthesis processes that use covariance loss and/or mean loss in accordance with various embodiments of the invention are described above, other processes that use covariance loss and mean loss in accordance with various other embodiments of the invention that add, combine and/or remove steps as necessitated by the requirements of particular systems and/or processes are possible.", "Histogram Losses Due to the multiple cluster problem, processes in accordance with a number of embodiments of the invention may use Histogram loss as described above to achieve consistently high-quality results.", "In accordance with several embodiments, the multiple cluster problem may be dealt with by using an automatic clustering process on the feature vectors to identify different textures in an image.", "The clustering process could transform the image so that each cluster is centered around its mean.", "However, the use of an automatic clustering process may introduce a number of additional problems.", "For example, if different linear transforms are applied to different regions of the image in a discrete way, seam lines may appear along the borders between different texture clusters.", "To deal with these seams, processes in accordance with many embodiments of the invention interpolate the transform between clusters.", "The interpolation may be more difficult than simply adding a histogram loss that has been shown to solve the same problem as discussed above.", "In accordance with particular embodiments of the invention, the instability of Gram or Covariance matrices is addressed by explicitly preserving statistical moments of various orders in the activations of a texture.", "In accordance with many embodiments, an entire histogram of feature activations is preserved.", "More specifically, systems and processes in accordance with a number of embodiments augment synthesis loss with m additional histogram losses, one for each feature in each feature map.", "Additionally, systems and processes in accordance with several embodiments incorporate a total variation loss that may improve smoothness in the synthesized image.", "As such, the combined loss for texture synthesis in CNN-based image synthesis processes in accordance with some embodiments of the invention is: texture(ours)=gram+histogram+tv (9) where Lgram can be interchanged with Lcovariance arbitrarily.", "However, it can be slightly subtle to develop a suitable histogram loss.", "For example, a naive approach of directly placing L2 loss between histograms of the input source texture image S and output synthesized image O has zero gradient almost everywhere and does not contribute to the optimization process.", "As such, CNN-based image synthesis processes in accordance with many embodiments of the invention use loss based on histogram matching.", "To do so, the synthesized layer-wise feature activations are transformed so that their histograms match the corresponding histograms of the input source texture image S. The transformation can be performed once for each histogram loss encountered during backpropagation.", "To do so, CNN-based image synthesis processes in accordance with a number of embodiments of the invention use an ordinary histogram matching technique to remap the synthesized output activation to match the input source image activations.", "In such a technique, Oij represents the output activations for a convolutional layer i and feature j, and O′ij represents the remapped activations.", "The technique may compute a normalized histogram for the output activations Oij and match it to the normalized histogram for the activations of input source image S to obtain the remapped activations O′ij.", "This technique is then repeated from each feature in the feature map to determine a Frobenius norm distance between Oij and O′ij.", "The loss of the histograms may be expressed as: ℒ histogram = ∑ l = 1 L  γ l   O i - R  ( O i )  F 2 ( 10 ) Where Oi is the activation map for feature map I and R(Oi) is the histogram remapped activation map, and γl is a user weight parameter that controls the strength of the loss.", "As R(Oi) has zero gradient almost everywhere, it can be treated as a constant for the gradient operator.", "Thus, the gradient of equation (10) can be computed by realizing R(Oi) into a temporary array O′l and computing the Frobenius norm loss between Oi and O′i.", "Although CNN-based image synthesis processes that use histogram loss in accordance with various embodiments of the invention are described above, other processes that provide histogram loss in accordance with various other embodiments of the invention that add, combine and/or remove steps as necessitated by the requirements of particular systems and/or processes are possible.", "Application of Histogram Loss to Style Transfers Style transfer is a broadening of texture synthesis.", "In texture synthesis, an input texture is statistically resynthesized.", "Style transfer is similar with the additional constraint that the synthesized image O should not deviate too much from a content image C. To do so, CNN-based image synthesis processes that perform style transfer in accordance with sundry embodiments of the invention include both a per-pixel content loss and a histogram loss in the parametric synthesis equation such that the overall loss becomes: transfer(ours)=gram+histogram+content+tv (11) where Lgram is interchangeable with Lcovariance for the purposes of our algorithm.", "Although CNN-based image synthesis processes that use histogram loss to perform style transfer in accordance with various embodiments of the invention are described above, other processes that use histogram loss to perform style transfer in accordance with various other embodiments of the invention that add, combine and/or remove steps as necessitated by the requirements of particular systems and/or processes are possible.", "Automatic Tuning of Parameters CNN-based image synthesis processes in accordance with some embodiment automatically determine parameters for the processes performed.", "The parameters may include, but are not limited to, the coefficients α1 in the Gram/Covariance loss equation (1), β1 in the content loss of equation (4), γl in the histogram/mean loss equation (1) and ω that is multiplied against the total variation loss.", "Automatic tuning processes in accordance with many embodiments of the invention are inspired by batch normalization that tunes hyper-parameters during a training process to reduce extreme values of gradients.", "The parameters may also be dynamically adjusted during the optimization process.", "In accordance with a number of embodiments, the dynamic tuning can be performed with the aid of gradient information.", "During backpropagation, different loss terms Li, may be encountered.", "Each loss term Li has an associated parameter ci that needs to be determined (ci is one of the parameters αl, βl, γl, and ω).", "A backpropagated gradient gi may first be calculated from the current loss term as if ci were 1.However, if the magnitude of gi exceeds a constant magnitude threshold Ti, then the gradient gi may be normalized so that its length is equal to Ti.", "Magnitude thresholds of 1 can be used for all parameters except for the coefficient αl of the Gram/Covariance loss, which may have a magnitude threshold of 100 in accordance with several embodiments.", "As can readily be appreciated, magnitude thresholds and/or other constraints can be specified as appropriate to the requirements of a given application.", "Although CNN-based image synthesis processes that perform automatic tuning in accordance with various embodiments of the invention are described above, other processes that provide automatic tuning in accordance with various other embodiments of the invention that add, combine and/or remove steps as necessitated by the requirements of particular systems and/or processes are possible.", "Multiscale Pyramid Based Synthesis CNN-based image synthesis processes in accordance with certain embodiments include manual and automatic control maps that were previously used in non-parametric approaches.", "To achieve this, processes in accordance with many embodiments perform a coarse-to-fine synthesis using image pyramids.", "In accordance with a number of embodiments, a ratio of two is used between successive image widths in the pyramid.", "A comparison of results of texture synthesis performed in accordance with various embodiments of the invention with and without the use of pyramids are shown in FIG.", "4.In FIG.", "4, images 401 and 402 are the style images and images 410-411 and 420-421 are the content images.", "Images 410 and 411 were generated without the use of pyramids and images 420 and 421 were generated with the use of pyramids.", "Images 410 and 420 show that pyramids blend coarse scale style features with content features better.", "Images 411 and 421 may show that pyramids transfer coarse scale features better and reduce CNN noise artifacts.", "Images 412 and 422 are magnified from images 411 and 421, respectively, and may show noise artifacts (in image 412) and better transfer of coarse-scale features (in image 422).", "Processes for Providing Convolutional Neural Network Based Image Synthesis Using Localized Loss Functions A process for providing CNN-based image synthesis that performs style transfer using localized loss functions in accordance with an embodiment of the invention is shown in FIG.", "5.In process 500, a source content image and a source style image are received (505, 510).", "The source content image includes the structures that are to be included in a synthesized image and the source style image includes a texture that is to be applied to the synthesized image.", "The process 500 determines localized content loss functions for groups of pixels in the source content image (515) and/or localized style loss functions for groups of pixels in the source style image (520).", "In accordance with some embodiments, the localized content loss functions and/or localized style loss functions may be generated using a CNN.", "The determinations of the localized content and/or style loss functions based upon various groupings of the pixels in accordance with various embodiments of the invention are described below.", "Process 500 performs an optimization process using the localized content loss functions and/or localized style loss functions to cause the pixels in the synthesized image to form an image with a desired amount of content from the content source image and a desired amount of texture from the source style image (525).", "In accordance with certain embodiments, the optimization process may be an iterative optimization process that is performed until a desired result is achieved.", "In accordance with many embodiments, the iterative optimization process may be performed by a backpropagation through a CNN iterative optimization processes in accordance with various embodiments of the invention are described in more detail below.", "Although processes for providing convolutional neural network based image synthesis by performing style transfer using localized loss functions in accordance with various embodiments of the invention are discussed above, other processes may be modified by adding, removing, and/or combining steps of the described processes as necessitated by system and/or process requirements in accordance with various embodiments of the inventions.", "Localizing Style Losses Style loss functions reproduce the textural component of the style image.", "Thus, a global style loss function may be transformed into a stationary representation (i.e.", "the representation is a culmination of the local patches of texture independent of the location of each local patch in the image).", "A global style loss function approach may generate the global style loss function by applying the source style image to a CNN, gathering all activations for a layer in a CNN and building a parametric model from the gathered activations of the layer.", "An optimization process may then be used to cause the loss function of one image to appear statistically similar to the loss function of another image by minimizing the error distance between the parametric model of the loss functions of the two images (which act as a statistical fingerprint that is being matched).", "A style transfer approach using a global style loss function may lead to unimpressive results as shown by the images illustrated in FIG.", "6.In FIG.", "6, Brad Pitt's image 601 is matched to an image of Picasso's self-portrait 602.In the resulting image 603, the overall style of the painting in the image 602 is transferred including the individual brush strokes, the general color palette and the overall look.", "This makes the image 603 look similar to the image 602.However, the individual features that compose the face are not transferred.", "Thus, Brad Pitt's eyes, nose and mouth do not look like Picasso's corresponding features.", "In accordance with sundry embodiments of the invention, a collection of strategies designed to transform the style of an image locally rather than globally may be performed.", "However, the various strategies used in the various embodiments involve a similar core idea of using a collection of parametric models representing local loss functions in either one or both of the source content image and the source style image, as opposed to using a single parametric model for each image.", "Each of the parametric models of an image summarize specific features in the image and are distinct and/or unique from the other parametric models in the collection of matrices for the image.", "The application of local loss functions may vary greatly between the various embodiments, depending on a desired degree of locality.", "Thus, each of the models may represent very large regions of the image in accordance with some embodiments when it is desired to have very little locality.", "Alternatively, the models may each represent smaller groups down to an individual pixel in accordance with particular embodiments of the invention where a very high degree of locality is desired.", "Region-Based Style Transfers Region-based style transfer may be used in accordance with some embodiments of the invention.", "A process for generating a region-based loss function in accordance with an embodiment of the invention is shown in FIG.", "7.A process 700 may generate a mask with one or more regions for both of the source content and source style images (710).", "In accordance with various embodiments, the regions may be determined by a user and received as a manual input of the user into the system.", "In accordance with many embodiments, processes may generate the regions of the mask through a neighbor matching process and/or other similar process for structure identification.", "The process 700 applies the masks to each image and determines a region of the mask associated with each pixel in each of the images (715).", "The process 700 assigns each pixel to the region determined to be associated with the pixel (720).", "The process 700 then generates parametric models for each of the identified regions of the masks from the pixels associated with the regions (725) and may add the generated parametric model for each region to an array of matrices stored in memory.", "In accordance with many embodiments, the mask value of each pixel may be used to index the pixel into the proper parametric model in the array for use in the style transfer process described above.", "Images that illustrate a region-based style transfer process performed on the images of Brad Pitt and Picasso's self-portrait 601 and 602 in accordance with an embodiment of the invention are shown in FIG.", "8.In region-based style transfer, distinct features of an image can be clustered together.", "As shown by image 802, Picasso's portrait from image 602 is segmented into a few distinct regions.", "For example, the eyes may be one region with the lips, nose, hair, skin shirt and background each being in their own regions.", "A mask 802 may be applied over image 602 to identify the region that contains each pixel in the image 602.Likewise, a mask shown in image 801 may be applied to the image 601 of Brad Pitt to identify the pixels that belong to each of the identified regions of the image 601.Although processes that provide region-based loss functions in accordance with various embodiments of the invention are described above, other processes that provide region-based loss functions in accordance with various other embodiments of the invention that add, combine and/or remove steps as necessitated by the requirements of particular systems and/or processes are possible.", "Uniform Segments Style Transfer In accordance with a number of embodiments of the invention, a uniform segment style transfer process may be performed.", "In uniform segment style transfer, the images are divided into uniform segments.", "The images of Brad Pitt and Picasso's self-portrait divided into uniform segments in accordance with an embodiment of the invention that uses uniform segments are shown in FIG.", "9.A process for performing uniform style transfer in accordance with an embodiment of the invention is shown in FIG.", "10.As shown in images 901 and 902 of FIG.", "9, a process 1000 of FIG.", "10 divides each image into a grid of regions or cells (1005).", "In particular, images 901 and 902 are divided into grids of 8×8 cells in the shown embodiment.", "However, any number of cells may be used in grids, for example 16×16 and 20×20 grids, in accordance with various other embodiments of the invention.", "Each cell is associated with an individual parametric model of a localized loss function (1010).", "In many embodiments, the generated parametric models can be added (1015) to an array of models for each image.", "In accordance with some embodiments, an individual parametric model may be associated (1020) with groups of cells that are determined by similarity of the cells or by some other manner.", "After the parametric models are generated, the parametric models may be used as a descriptor for nearest neighbor matching of the pixels in associated cell(s).", "The nearest neighbor matching binds cells together so that each cell in the content image is optimized more closely resemble a cell in the style image that is determined to most closely approximate the cell as shown in FIG.", "11.In FIG.", "11, a cell 1101 in the image 901 is optimized to a cell 1102 in the image 902.In accordance with some embodiments, one or more cells in the style image that most closely approximate a cell in the content image may be identified by determining the cell(s) in the style image that has a minimum L2 distance between its parametric model and the parametric model of the cell in the content image.", "In accordance with certain embodiments, the optimizing processes for all of the cells in the content image are performed in parallel.", "Although processes that provide uniform segment style transfer in accordance with various embodiments of the invention are described above, other processes that provide segment-based style transfer in accordance with various other embodiments of the invention that add, combine and/or remove steps as necessitated by the requirements of particular systems and/or processes are possible.", "Per Pixel Style Transfer In accordance with particular embodiments of the invention, each pixel is a local region.", "Images that show the association between pixels in a source content image and a source style image in accordance with a certain embodiment of this invention are shown in FIG.", "12.In accordance with many embodiments, a parametric model of a localized style loss function is generated for each pixel in the content image cell 1201 and the style image cell 1202.A process for generating localized style loss functions in accordance with an embodiment of the invention is shown in FIG.", "13.The process 1300 includes gathering a neighborhood of pixels surrounding each particular pixel in the source content image (1305).", "A group of pixels in the source style image that are associated with the neighbor pixels of each particular pixel is determined (1310).", "In accordance with sundry embodiments, a pre-computed nearest neighbor set may be used to associate each pixel in the content image with a pixel in the source style image.", "The group of pixels in the source style image associated with the neighborhood of each particular pixel is used to generate the parametric model of the localized style loss function that the particular pixel is optimized toward (1315).", "Although processes that provide per pixel-based style transfer in accordance with various embodiments of the invention are described above, other processes that provide per pixel-based style transfer in accordance with sundry embodiments of the invention that add, combine and/or remove steps as necessitated by the requirements of particular systems and/or processes are possible.", "From the above descriptions of the various transfer strategies, one may see that regional segment style transfer is simple and fast compared to the other transfer strategies.", "However, the regional segment style transfer can be imprecise, whether a human or a CNN is used to determine how the parametric models are generated.", "The cell transfer can differ from the regional transfer in that many more parametric models are generated and the matrices themselves are used to determine the correspondence of features.", "The per pixel approach is typically the most precise and the slowest possible transfer strategy because the amount of computations needed is increased by generation of a parametric model for each particular pixel from patches of pixels around the particular pixel.", "The increase in computations stems from the fact that in the other approaches each of the pixels in an image contribute to one parametric model and in the per pixel approach each pixel contributes to the parametric model of each of the neighboring pixels.", "Furthermore, it is noted that various other embodiments may select certain other manners in determining local regions to refine the trade-off between speed and/or memory versus accuracy.", "Localizing for Content Loss In accordance with particular embodiments, content loss can be used for the transfer process instead of style loss.", "The difference is that style loss attempts to be stationary and content loss does not.", "For purposes of this discussion, stationary means that the location of a pixel is the main factor influencing what the pixel should look like.", "The content loss function can be simple in accordance with some embodiments in that the L2 (or Euclidian) distance is summed for each pixel in the synthesized image to each pixel at the same location in the content image.", "The goal of content loss, on the other hand, is to reproduce the “structure” of the content image (image 1401 of FIG.", "14 showing the Golden Gate Bridge) while allowing the nonstructural aspects of the image to mutate towards resembling the style image (image 1402 of FIG.", "14 showing Starry Night).", "In accordance with other known transfer processes, one may assume that the deeper layers of the network represent the higher order image features, so by maintaining a low error between content and synthesis deeper in the network but allowing the style to be optimized at the shallow layers, a balance is reached between the style and content.", "However, these processes often do not regularly provide compelling results.", "A problem with using a global content loss in a style transfer process may be that all of the regions of the content image may not be equally as important in terms of key shapes and structures in the image.", "For instance, in FIG.", "15, image 1501 of the Golden Gate Bridge, the low-importance content features including the low frequency sky and ocean are given a high enough content loss to overpower the style contribution and stop large, swirly clouds and stars from forming.", "In parallel, the high-importance content features including the bridge are largely being distorted by the style image.", "This makes the high-importance content features lose fine scale qualities such as the cable stretching from tower to tower.", "Furthermore, the tower in the background is more distorted than the larger tower in the foreground because the tower in the background is smaller in terms of image size.", "However, the tower in the background is not less important than the tower in the foreground in terms of content as the tower is a key structure in the image.", "Style transfer processes that use localized content loss functions in accordance with some embodiments of the invention may provide weights to each pixel based on the amount that the pixel contributes to a key shape or structure in the image.", "However, “content” can be a poorly defined concept with respect to art as “content is subjective and can be subject to personal interpretation.", "As such, the process for localizing content loss in accordance with some embodiments of the invention is based on the following observations about “content.” For the purposes of determining the contribution of a pixel to content, one may observe that flat, low frequency regions of an image generally do not contribute to the content of the image (for purposes of human perception) while high frequency regions generally are important contributors to the content.", "Therefore, style transfer processes in accordance with many embodiments of the invention may use a Laplacian Pyramid of black and white versions of the content image (Images 1601-1604 in FIG.", "16) to determine content loss weights for each pixel in the image being synthesized where the high frequency pixels (whiter pixels) have a higher influence on content than low frequency pixels (darker pixels).", "Alternatively, convolutional neural networks (CNNs) trained on image classification tend to learn kernels at the deeper levels of the network that recognize shapes which are structurally meaningful to humans.", "Therefore, the magnitude of feature vectors produced from the content image deep in the network can also be used as a scaling factor for the content loss itself.", "The difference between the use of global style loss and global content loss is shown by the images shown in FIG.", "17.An image 1701 shows an image generated using global style loss and an image 1702 shows an image generated using global content loss starting from noise and use the respective global loss functions to generate the final image.", "The image 1701 illustrates global style loss with no content loss producing a “texturized” version of the style image (Starry Night).", "Image 1702, on the other hand, introduces global content loss to the texturized version and the texturized version of Starry Night is reshaped into the form of the Golden State Bridge but with the flaws identified above.", "The difference between the use of a global content loss functions and the use of localized content loss functions determined using a Laplacian Pyramid in accordance with a certain embodiment of the invention is shown in FIG.", "18.An image 1801 is the same as the image 1702 and introduces global content loss to the texturized version of the image, and an image 1802 introduces local content loss based upon a Laplacian Pyramid to the texturized version instead of the global content loss.", "The features in the image 1802 emerge (i.e.", "the bridge and the land) while the rest of the image reproduces the texture of Starry Night more accurately.", "Although previous processes may start from noise, noise does not have to be the starting point in some embodiments of this invention.", "The logic of starting from noise may be that noise often produces a slightly different version of the transfer each time.", "In accordance with a number of embodiments of the invention, CNN backpropagation may be used to provide a style transfer process using global and/or local content loss.", "The use of CNN backpropagation can allow the image to be thought of as a point in a super-high dimensional space (a dimension for each color channel in each pixel of the image).", "The optimization process is a gradient descent optimization that pulls an image at that point through the image's high dimensional space toward a new point that is within a small region of the high dimensional space that is considered “good output.” The force that pulls the image may be the combined loss function for style and content as well as optimizing towards a local minimum of the function, depending on where the noise commences in this space.", "Alternatively, the optimization process may be started from the content image instead of noise in accordance with a number of embodiments.", "Using the standard approach, the use of the content image to start may not offer an advantage because the content loss may begin from an optimal position and play a more aggressive “tug of war” against the style loss resulting in an image that has more content and less style.", "In summary, when starting from noise, both loss functions (content and style) are often very bad and move together toward a mutually optimal choice for most of the processes whereas, when starting from the content image, the two loss functions are often fighting against each other during the entire process, and that may return a less than pleasing result.", "The use of content loss in style transfer processes in accordance with particular embodiments of the invention has certain advantages that known style transfer processes typically have previously overlooked.", "If the content loss is removed from the function leaving only style loss, a texturized version of the image (as shown in FIG.", "19, image 1901) is generated with the subtle difference that the content image (i.e.", "the starting point in high dimensional space) exists in a local minimum within the space of all possible versions of the texturized version of the style image.", "As such, starting at the content image and removing the content loss causes the process to start at a point in space that is the content image and move away from this point in the high dimension space to a point that is pure style, but the process arrives at a local minimum that represents both style and content in a much better localized ratio than is typically produced by known processes as shown in an image 1901 of FIG.", "19.The image 1901 was generated by starting at the content image of the Golden Gate Bridge and then optimizing using only style loss so that the image mutated to better resemble “Starry Night” until the process reached a local minimum.", "This produces better results than previously known style transfer processes.", "However, the results may be improved by re-introducing localized content loss instead of global content loss that results in image 1902.This approach addresses the problem of removing content loss completely by trying to reach a local minimum in the optimization process that does not cause key structures (e.g.", "the cables on the bridge and the tower in the background) to be mutated too much by the style loss and lose the distinguishing characteristics of these structures.", "By re-introducing local content loss in accordance with some embodiments of the invention, the mutation of structurally important aspects of the content too far in the style direction may be reduced leading to an optimization process that reaches a more desirable local minimum.", "Localized style and content loss are also applicable within a feedforward texture synthesis and style transfer algorithm and are not limited to an optimization framework using backpropagation.", "Although processes that provide style transfer using global and/local content loss in accordance with various embodiments of the invention are described above, other processes that provide style transfer using global and/or local content loss in accordance with various other embodiments of the invention that add, combine and/or remove steps as necessitated by the requirements of particular systems and/or processes are possible.", "Localized Style Loss for Artistic Controls In accordance with sundry embodiments of the invention, CNN-based image synthesis processes separate multiple textures in an image into multiple models to determine localized loss.", "To do so, processes in accordance with many embodiments receive an index mask for the source texture or style image and an index mask for the synthesized image.", "In accordance with a number of embodiments, each mask is input by a user.", "Each mask may include M indices.", "This may sometimes be referred to as a “painting by numbers” process.", "A process for determining localized loss using masks in accordance with an embodiment of the invention is shown in FIG.", "20.A process 2000 applies the mask for the source image to the source image to determine the pixels that belong to each of the M indices (2005) and the mask to the synthesized image to determine the pixels that belong to each of the M indices of the synthesized mask.", "A parametric model is generated for each of the M indices of the source style mask from the pixels that belong to each of the M matrices (2010).", "The indices of the synthesized output may be tracked though an image pyramid for coarse-to-fine synthesis (2015).", "During synthesis, the previous losses are modified to be spatially varying (2020).", "In accordance with many embodiments, spatially varying Gram/Covariance matrix and histogram losses may be imposed where the style Gram/Covariance matrices and histograms vary spatially based on the output index for the current pixel.", "Histogram matching is then performed (2025).", "In accordance with several embodiments, the histogram matching may be performed separately in each of the M regions defined by the indexed masks.", "Blending of adjacent regions may then be performed (2030).", "In accordance with a number of embodiments, the bending of adjacent regions can be automatically performed during backpropagation.", "In accordance with certain embodiments of CNN-based image synthesis, it is important to note that often the style and content source images contain sets of textures that are semantically similar and should be transferred to each other.", "An example of this is shown in FIG.", "21.FIG.", "21 also shows images synthesized in accordance with particular embodiments of the invention and images generated using other processes.", "In FIG.", "21, images 2101 an example of controllable parametric neural texture synthesis.", "Original images are on the left, synthesis results on the right; corresponding masks are above each image.", "Rows of images 2105, 2110 and 2115 are examples of portrait style transfer using painting by numbers.", "Rows of images 2110 and 2115 show style transfer results for an embodiment of the invention on the far right as compared to images generated by another process in middle.", "The images can show that processes in accordance with some embodiments of the invention may preserve fine-scale artistic texture better.", "However, processes in accordance with certain embodiments of the invention may also transfer a bit more of the person's “identity,” primarily due to hair and eye color changes.", "Implementation Details of CNN Based Image Synthesis Systems that Use Histograms In accordance with sundry embodiments of the invention, the CNN used may be a VGG-19 network pre-trained on the ImageNet dataset.", "In accordance with many embodiments, layer Rectified Linear Unit (relu) 1_1, relu 2_1, relu 3_1 and relu 4_1 may be used for Gram losses.", "The histogram losses may be computed only at layers relu 1_1 and relu 4_1 in a number of embodiments.", "Content loss is computed only at relu 4_1 In accordance with several embodiments.", "Furthermore, the total may only be performed on the first convolutional layer to smooth out noise that results from the optimization process.", "In accordance with particular embodiments, the images are synthesized in a multi-resolution process using an image pyramid.", "During synthesis, the process begins at the bottom of the pyramid that can be initialized to white noise, and after each level is finished synthesizing, a bi-linear interpolation is used to upsample to the next level of the pyramid.", "Although CNN-based image synthesis systems in accordance with various embodiments of the invention are described above, other configurations of the CNN-based systems that add, modify and/or remove portions of the CNN in accordance with various embodiments of the invention are possible.", "Controlling Age Appearance within Parametric Models The apparent realism and/or quality of a synthesized image can be improved by applying synthetic weathering.", "Textures that display the characteristics of some weathering processes may incorporate a collection of multiple textures consolidated into one weathered texture.", "As such, CNN-based image synthesis processes in accordance with some embodiments of the invention may provide a new approach for controlling the synthesis of these complex textures without having to separate the textures into different parametric models.", "This may be achieved by directly controlling the synthesis process by strategically waxing and waning specific parameters in the model to create new outputs that express different ratios of desired features to control the appearance of age for certain textures.", "Identifying Age Features within Exemplar Images A separate but entangled problem to controlling age appearance during synthesis is first identifying which features in the input exemplar image display characteristics of age and to what degree.", "In accordance with sundry embodiments, user-created masks that delineate feature age may be received and used to identify the features.", "Processes in accordance with many embodiments may use an automatic clustering approach to segregate different textures.", "Still other processes in accordance with a number of embodiments may use a patch-based method that uses the average feature distance between a patch and its K nearest neighbors as a metric for “rarity” that may be interpreted as age.", "This method is based on the assumption that features created by the weathering process are highly random and have a low chance of finding a perfect match caused by the same process.", "However, there may be a limitation in the patch-based approach when a texture has rare features that are not a product of age, such as knots in wood.", "In accordance with several embodiments, a CNN may be trained to learn and identify weathered features for a multitude of weathering types.", "Processes for Controlling Aging Once weathered regions in an image have been identified, CNN-based image synthesis processes in accordance with particular embodiments of the invention can extract a parametric model for each region.", "The desired age can be produced as a linear combination of the separate models.", "In the simplest case, weathering may just be an interpolation between a Young and Old parametric model as follows: Page=Y*(1−age)+O*(age) (13) This naive approach cannot generate fully young or fully old textures due to the large receptive fields common in CNN architectures mixing the two parametric models.", "To circumvent this problem, processes in accordance with many embodiments may introduce a “transition” parametric model built from the bordering pixels between young and old regions.", "To do so, processes in accordance with a number of embodiments of the invention may dynamically generate masks for each layer of the network corresponding to the receptive field.", "Examples of a mask are shown in FIG.", "22 where black is used to delineate the young model, white for the old model and grey for the transition model.", "With specific regard to FIG.", "22, (a) indicates an input texture image, (b) indicates a mask delineating young and old textures, (c)-(f) indicate different receptive fields measured in terms of layers of rectified linear units for the Gram losses in texture synthesis and style transfer.", "The aging process in accordance with some embodiments then may become a two-step process where, first, Young to Transition is synthesized and then Transition to Old is synthesized.", "This strategy works for textures that completely change from one material to a completely different material as the textures age.", "However, weathering often damages or deforms a young material rather than transforming it into a completely different material (e.g.", "scratching, cracking, peeling).", "Therefore, it is typical that a young model should not contain old features, but the old model should contain young features.", "In this scenario, the old and transition regions may be combined into a single combined parametric model.", "Aging processes in accordance with many embodiments of the invention may use a simple strategy for determining whether the transition and old models should be combined or not.", "The strategy is based upon the observations that when generating the transition masks as shown in FIG.", "22, the transition region becomes larger for deeper layers of the network.", "Therefore, if at some layer in the network the transition region completely replaces either a young or an old region, the processes assign that region into transition model at all layers of the network.", "Thus, the transition region can effectively “annex” other features if the features are too small to justify having their own parametric model.", "Given the introduction of a third “transition” model, the equation (12) above no longer suffices.", "In addition to the three-model system, processes in accordance with a number of embodiments may extend the algorithm to account for an arbitrary number of parametric models for complex aging scenarios.", "When more than two age models are present, there are two equally appropriate synthesis strategies.", "First, each parametric model can have an age assigned to it between 0 and 1.In the first strategy used by processes in accordance with a number of embodiments of the invention, a list of N parametric models is sorted by age value from smallest to largest giving N−1 pairs of models to linearly interpolate between.", "These interpolations are sequentially chained such that the youngest model is the Y model and the next youngest is the O model.", "Once the old texture is fully synthesized, set the Y model to the O model and replace the O model with the next youngest model.", "The process may then iterate until all of the parametric models have been processed.", "In the second strategy used by a few embodiments, all N parametric models may be combined in parallel.", "This results in a single parametric model that is a combination of an arbitrary number of models in any proportion.", "Although CNN-based image synthesis processes that perform aging in accordance with various embodiments of the invention are described above, other processes that perform aging in accordance with various other embodiments of the invention that add, combine and/or remove steps as necessitated by the requirements of particular systems and/or processes are possible.", "Continuous Weathering Once a new texture is synthesized at a starting age, it can be a simple process to continue the optimization while iteratively replacing the combined parametric model to reflect a new age.", "CNN-based image synthesis processes in accordance with particular embodiments of the invention may use this approach to synthesize smoothly varying animations from one age to another.", "Since a new parametric model for texture or “style” is introduced, and the optimization process starts from a prior model that represents the desired content, this process can be considered a special type of style transfer process where the style transfer process is a useful way to frame the problem.", "One complication to note is that changing the parametric model can cause a subtle mutation of features that should otherwise be static.", "While the ultimate goal is to replace young features with old ones, it is also possible for the young features to mutate into new but equally young-looking features due to the parametric model being in flux.", "In addition, old features may continue to optimize once they are synthesized, breaking the illusion of an aging process.", "In order to stabilize non-transitional features, processes in accordance with many embodiments introduce a new component, a multi-target localized content loss.", "In the most basic case, there are only young and old regions in a texture.", "In order to avoid the continuous mutation effect, these processes may introduce a new content loss strategy that applies different targets to local regions.", "These processes may begin by first synthesizing a full image for each of the two parametric models to be used as multiple content images.", "For each local point in the synthesis image, the processes may dynamically choose which content loss to apply based on a “parametric heat map.” To generate the parametric heat map, the mean of a parametric model is subtracted from each pixel of the model and the co-activations to form a covariance matrix for that individual feature.", "In accordance with a number of embodiments, this may be performed in the rectified linear units for the Gram losses in texture synthesis and style transfer for layer 4 (relu_4) of the VGG-19 network.", "Next, the L2 distance between this covariance matrix and the covariance matrix component of the young and old parametric models is found for each pixel.", "The parametric model that has the lowest error can be used to compute the content loss for the pixel using the corresponding content image.", "Alternatively, processes in accordance with a few embodiments implement this approach by generating a new single content image by choosing pixels from the different content images using the lowest error mask.", "As can readily be appreciated, the specific approach that is pursued is typically dependent upon the requirements of a given application.", "Controlling Weathering Through “Painting by Numbers” Continuously updating a single parametric model can lead to natural weathering patterns.", "However, it is difficult to manually control this process.", "As an alternative weathering approach, processes in accordance with sundry embodiments extend the painting by numbers strategy presented above where masks are directly drawn or procedurally generated which direct young, old and transition textures to different regions of the synthesis image over time.", "The ability to procedurally control a weathering process may be important for many textures where different regions can be affected by different environmental conditions in a 3D scene.", "Although CNN-based image synthesis processes that control weathering through “painting by numbers” in accordance with various embodiments of the invention are described above, other processes that control weathering through “painting by numbers” in accordance with certain embodiments of the invention that add, combine and/or remove steps as necessitated by the requirements of particular systems and/or processes are possible.", "Continuous Multiscale Aging In accordance with sundry embodiments, CNN-based image synthesis processes re-purpose style transfer to generate a continuous and progressive aging/de-aging process in a multiscale pyramid framework.", "Style transfer may be considered an extension to texture synthesis in which a second content image is introduced to guide the optimization process.", "Processes in accordance with many embodiments use the same concept to synthesize time sequences in a multiscale pyramid framework.", "These processes may bootstrap the animation by synthesizing the first frame in the sequence using the strategy described above.", "After the first frame is generated, subsequent frames can be created by using the frame before as a prior frame.", "As such, at any given point in time, two image pyramids are stored in memory, the pyramid for the previous frame and the pyramid for the current frame being synthesized.", "The synthesis order is illustrated in FIG.", "23.As the multiple image sizes may be synthesized in parallel, processes in accordance with a number of embodiments may store an optimizer state for each pyramid level.", "When synthesizing the first frame in the sequence, the base of the pyramid may use white noise as a prior frame to start the synthesis and then each subsequent pyramid level starts from the final result of the previous level that is bi-linearly re-sized to the correct resolution.", "For all subsequent frames synthesized, a new image pyramid may be synthesized.", "In accordance with a number of embodiments, the first level of the new pyramid uses the first level of the previous frame as a prior image.", "For higher layers in the pyramid, the same layer from the previous frame is used as a prior image and a content loss is introduced by re-sizing the previous layer in the same frame, this content image can be seen as a blurry version of the desired result.", "This process is conceptually illustrated in FIG.", "23 where image 5 is synthesized using image 2 as a prior and image 4 is re-sized and used as a content image to guide the process.", "By synthesizing a sequence of images in this manner CNN-based image synthesis processes in accordance with some embodiments achieve the same benefits as synthesizing a single image using the pyramid strategy.", "However, the fidelity of larger structures may be improved, noise artifacts may be reduced and synthesis speed may be improved.", "Although CNN-based image synthesis processes that perform continuous multiscale aging in accordance with various embodiments of the invention are described above, other processes that perform continuous multiscale aging in accordance with various other embodiments of the invention that add, combine and/or remove steps as necessitated by the requirements of particular systems and/or processes are possible.", "Transferring Weathered Patterns from External Exemplars Arguably, it is more useful sometimes to transfer the weathering effects of one material “W” onto another material “C.” This is a more difficult problem as the parameters within W that represent aged features must be completely extracted and isolated from the parameters that encode the underlying texture.", "The only way to do this accurately is to give every pixel a high fidelity age scoring.", "While, other systems may be able to accomplish this through a nearest neighbor search, this approach is too coarse and approximate to accurately transfer weathering.", "Also, some of these other processes may rank pixels based on how unique the pixels are within the image.", "To perform transferring of weathering patterns in accordance with several embodiments of the invention, pixels may also need to be ranked based on which distinct features they contribute to and by how much.", "CNN-based image synthesis processes in accordance with particular embodiments can accomplish this using the heat-map approach presented in the previous section on continuous weathering.", "However, rather than finding the best match among all parametric models, Processes performing weather transfer keep a separate L1 distance score between each parametric model.", "Thus, these processes may discriminate on a pixel-by-pixel basis to determine the pixels in a weathered region that contribute to the actual age artifacts and to what degree.", "Given a region of image W with age features as well as transition features and the resulting parametric model, the goal is to remove any features that are not the desired “aged” features and replace these features in the correct proportion with the target parametric model of C. To do so, processes in accordance with many embodiments normalize an L1 distance to each parametric model between 0 and 1 and invert the result so that a region in the synthesized image that strongly matches with a parametric model will receive a score close to 1 and regions that do not match receive a score closer to 0.For a parametric model that should be removed from the mixture, processes in accordance with a number of embodiments compute a mean activation of the model (note, co-activations are not used for this process as the features become very difficult to de-tangle).", "For each pixel, the processes may multiply the mean activation by the local L1 distance to that parametric model and subtract it from the activations at this target pixel to remove those features in their correct proportion from neural activations of the pixels.", "The processes may take the mean activations from the new parametric model from image C and multiply it by the same L1 distance to determine an activation value.", "The activation value is then added to the target pixel in W to replace the young features in the original image with young features from a new image where the weathered features are being introduced.", "After the texture has been updated, the processes can now perform weathering on image W using the processes described above.", "Although CNN-based image synthesis processes that transfer weathered patterns from external exemplars in accordance with various embodiments of the invention are described above, other processes that transfer weathered patterns in accordance with various other embodiments of the invention that add, combine and/or remove steps as necessitated by the requirements of particular systems and/or processes are possible.", "Combining Optimization and Feedforward Parametric Texture Synthesis for Fast, High Resolution Syntheses Neural network-based texture synthesis processes can be grouped into two categories based on their underlying algorithmic strategy.", "These include optimization-based and feedforward-based approaches.", "Optimization-based approaches often produce superior quality but may be computationally expensive.", "This often makes these processes impractical for real world applications.", "Feedforward-based approaches were developed as a fast alternative to optimization.", "This is achieved by moving the computational burden to the training phase rather than at run time.", "While being fast, feedforward approaches are typically poor in quality and inflexible.", "The first feedforward approach baked the transformation for a single texture into each network.", "Later, several methods introduced the idea that multiple texture transformations could be baked into a single network.", "One such method introduced the idea of interpolating between these styles by matching the statistics of deep neural activations from some content image to those of a style image.", "In addition to baking style transformations into a network, another strategy has been to train an auto-encoder that uses the standard fixed pre-trained VGG network as an encoder with a decoder that is trained to invert VGG.", "Style transfer can be achieved by directly modifying the activation values produced by the encoder so that they better match the style image.", "One approach is to replace each feature vector from the content with its nearest neighbor in the style.", "Impressive results can be achieved by transforming the content activations to better mimic the style activations through a whitening color transform (WCT), which is a linear transformation that is capable of matching covariance statistics.", "While these methods have greatly improved the flexibility and quality of feedforward methods, they can still be inferior to optimization.", "CNN-based image synthesis processes in accordance with some embodiments of the invention use a coarse-to-fine multiscale synthesis strategy for neural texture synthesis.", "These processes can achieve significant speedup over previous optimization methods by performing a majority of iterations on small images early in the process and the further the processes move up the pyramid, the less iterations are used to maintain the already established structure.", "The use of multiscale pyramid based synthesis is not only computationally cheaper as the processes move up the pyramid, but the problem formulation actually changes.", "Rather than performing texture synthesis or style transfer, the problem changes to Single Image Super Resolution (SISR) that takes an additional parametric texture model to help guide the up-resolution process.", "As such, CNN-based image synthesis processes in accordance with many embodiments of the invention may utilize the optimization-based approach described above up until an arbitrary threshold (for example, around the 512×512 pixel size image, varies depending upon the requirements of a given application) and then switch to an arbitrary feedforward approach utilizing VGG encoding/decoding with activation transforms along the way.", "Switching synthesis algorithms as the processes move up the pyramid can have additional benefits beyond speed.", "Some CNN-based texture synthesis processes are only capable of generating RGB color textures, a standard that has been obsolete in the video game and movie industries for nearly 20 years.", "Color textures have been replaced by “Materials” which consist of several maps encoding the fine scale geometry of the surface as well as parameters that direct how light interacts with each pixel.", "By utilizing a nearest neighbor search from the previous pyramid level to the most similar feature in the style exemplar, the encoder/decoder process in accordance with a number of embodiments can both up-resolution the previous synthesis level while also decoding the entire material.", "While it may be possible to train a new auto-encoder to process color images along with normal maps, roughness maps, etc.", "this process would have to be done for every possible combination of maps.", "This may be costly and awkward.", "This approach may provide a more flexible and elegant solution.", "Extending this concept to the arbitrary case, a method in accordance with several embodiments of the invention generates arbitrary material formats applied to any synthesis operation including, but not limited to, texture synthesis, time-varying weathering, style transfer, hybridization and super resolution.", "This synthesis strategy involves using some color texture generated using another process as input.", "In addition, an exemplar material is given as input, where this material contains at least one map that is similar in appearance and purpose as the input color map.", "The input color map is then used as a guide to direct the synthesis of the full material.", "This is done through a nearest neighbor search where a pixel/patch is found in one of the maps in the material that is similar to a pixel/patch in the input color image.", "The pointer map resulting from the nearest neighbor search directs how to re-arrange all maps within the material and then each can be synthesized using this same new guiding structure.", "These processes may be additionally attractive for style transfer because they are fully feedforward and the full resolution image can easily be broken up into deterministic windows that can be synthesized separately and stitched back together.", "This allows processes in accordance with particular embodiments to synthesize arbitrarily sized images with minimal engineering.", "Although CNN-based image synthesis processes that combine optimization and feed forward processes in accordance with various embodiments of the invention are described above, other processes that combine optimization and feed forward processes in accordance with various other embodiments of the invention that add, combine and/or remove steps as necessitated by the requirements of particular systems and/or processes are possible.", "SISR for Renderings In accordance with certain embodiments, a style transfer process used to perform SISR may have applications for rendering.", "SISR is an ill-posed problem where many high-resolution images can be downsampled to the same low-resolution result.", "This one-to-many inversion is especially bad at reproducing texture because it targets inverting to an average of all the possible higher resolution images.", "The latest trend in SISR is to train very deep (i.e.", "many layered) artificial neural networks on a large dataset using adversarial training.", "The high capacity of the deep network in conjunction with the adversarial training is meant to help reduce the loss of texture features.", "Recent advances in rendering algorithms as well as advances in high-resolution displays has resulted in an associated rise in rendering costs.", "The problem is that that there are more pixels and each pixel is more expensive to render.", "In particular, the recent jump from 1080p to 4 k rendering has left many animation houses incapable of meeting market needs.", "For small studios, the costs may be restrictive.", "For large and famous studios, rendering at 4 k may also be challenging.", "However, when rendering a movie or other video content, frames typically do not change significantly from one frame to the next.", "Therefore, it can be assumed that the parametric model or high-resolution texture statistics extracted from one frame are probably also appropriate for guiding similar but slightly different frames.", "Processes in accordance with some embodiments perform a video up-resolution strategy where the video content is rendered at a low resolution (LR).", "From the LR source, the processes cluster frames together based on their feature statistics.", "The mean frame from each cluster is determined and rendered at high resolution (HR).", "The processes then perform the same guided LR to HR synthesis as proposed for video streaming, with the one important difference that in video streaming the HR statistics for each frame are known whereas for rendering similar HR statistics are shared across multiple frames.", "Although CNN-based image synthesis processes that perform SISR for rendering in accordance with various embodiments of the invention are described above, other processes that perform SISR for rendering in accordance with various other embodiments of the invention that add, combine and/or remove steps as necessitated by the requirements of particular systems and/or processes are possible.", "Combining Parametric and Non-Parametric-Non-CNN Synthesis within Pyramid Frameworks Based on the processes described above, CNN-based image synthesis processes in accordance with many embodiments of the invention can use a nearest neighbor search between patches in the synthesized result to determine the most similar patches in the input exemplar in order to create a bridge between parametric CNN-based texture synthesis frameworks and many established non-parametric texture synthesis methods that do not require a neural network to operate.", "The ability to tether a neural network approach on low-resolution images with non-neural network based methods higher in the synthesis pyramid can represent a “best of both worlds” solution between the two strategies.", "CNN-based approaches, especially parametric methods may be better at producing creative new features at the cost of speed, memory and image quality (these methods may contain many noise artifacts).", "Non-parametric models that do not rely on neural networks tend to shuffle around patches directly from the input exemplar.", "As such, these approaches exhibit the inverse of these behaviors.", "They are fast, low memory approaches that largely match the fine details of the input.", "However, they are not as powerful at creating new shapes and features.", "Although processes that combine parametric and non-parametric-non-CNN synthesis within a pyramid framework in accordance with various embodiments of the invention are described above, other processes that combine parametric and non-parametric-non-CNN synthesis within a pyramid framework in accordance with various other embodiments of the invention that add, combine and/or remove steps as necessitated by the requirements of particular systems and/or processes are possible.", "Although the present invention has been described in certain specific aspects, many additional modifications and variations would be apparent to those skilled in the art.", "It is, therefore, to be understood that the present invention may be practiced otherwise than specifically described, including various changes in the implementation without departing from the scope and spirit of the present invention.", "Thus, embodiments of the present invention should be considered in all respects as illustrative and not restrictive.", "Dilated Network Architecture The examples disclosed above have largely been agnostic to network architecture and are transversal to many Convolutional Neural Network (CNN) architectures.", "However, in addition to the examples above, the system in accordance with several embodiments of the invention implements a new network architecture for image synthesis that is particularly well suited to the problem.", "In accordance with some embodiments of the invention, a combination of Pooling Layers, Strided Convolution Layers and Dilated Convolution Layers are used to arrange neurons into a hierarchical multiscale relationship.", "Typically, image synthesis algorithms utilize pooling layers and sometimes strided convolution layers in order to form an image pyramid structure within the neural network architecture.", "Typically, only one such strategy is used throughout the network architecture.", "Recent work in image segmentation has achieved performance improvements utilizing a dilated convolutional network (https://arxiv.org/pdf/1511.07122.pdf—the disclosure of which related to dilated convolutional networks is hereby incorporated by reference herein in its entirety), with a follow-up work showing that dilated convolution can also be used to learn image filters (http://vladlen.info/papers/fast-image-processing-with-supplement.pdf—the disclosure of which related to dilated convolutional networks is hereby incorporated by reference herein in its entirety).", "Dilated convolution is a similar concept to image stacks, first introduced for the purposes of image processing using signal and statistics based methods and later adapted for texture synthesis (Sylvain Lefebvre and Hugues Hoppe.", "2005.Parallel controllable texture synthesis.", "ACM Trans.", "Graph.", "24, 3 (July 2005), 777-786—the disclosure of which related to dilated convolutional networks is hereby incorporated by reference herein in its entirety).", "The image stack is a collection of image pyramids sampled from a single image at regular translation intervals.", "Image stacks were developed to address the problem that the image pyramid data structure leads to discretization errors, e.g.", "the same input image when translated could lead to very different downsampled results.", "The image stack is effectively a translation invariant alternative to image pyramids.", "It also follows that other types of symmetry transformations could also lead to similar discretization artifacts, e.g.", "two otherwise identical images would produce very different averages at coarser levels of an image pyramid.", "Other solutions to this problem include, but are not limited to, using a collection of image pyramids at different translations of an input image.", "An image stack can extend this concept to the most extreme conclusion where every possible image pyramid configuration is extracted from the original image, and then packed together efficiently so that all redundant data is removed.", "The efficient packing can be achieved using a “quadtree pyramid,” which was originally developed to accelerate an Approximate Nearest Neighbor (ANN) search utilizing KD-Trees.", "However, an image stack re-orders the data into a tightly packed image where features remain coherent across scale levels.", "The same data structure was actually first introduced a few years earlier by Masaki Kawase during a Game Developers Conference lecture for the purpose of blurring an image (slides published online by GDC, https://www.gamedev.net/forums/topic/615132-dof-basic-steps/Slides 15-18—the disclosure of which related to dilated convolutional networks is hereby incorporated by reference herein in its entirety).", "In an image pyramid structure, each level of the pyramid is typically half the resolution in each dimension as the previous level.", "In an image stack structure, each level is the same resolution as the previous level.", "In an image pyramid, samples are typically averaged together or combined in some way using a convolution kernel with a stride of 1, used uniformly at every pyramid level.", "In an image stack, samples are typically averaged together or combined in some way using a convolution kernel with a stride of 2level where level is the number of scale factors relative to the original image.", "This can be thought of as analogous to a downscaling transition in an image pyramid.", "In summary, image pyramids both downsample and subsample an image.", "While downsampling is a desirable operation, subsampling rarely is.", "Image stacks get around this problem by downsampling without subsampling.", "The same data structures and hierarchical relationships used for an image pyramid and an image stack can also be used for convolutional network architectures that utilize pooling layers or strided convolution as well as dilated convolution.", "As such, the advantages/disadvantages of using a stack versus a pyramid in an image processing framework are transversal and carry over to a convolutional neural network architecture.", "Replacing pooling or strided convolution with a dilated convolution will often yield superior image synthesis results.", "Previous image synthesis methods using a Convolutional Neural Network have used some kind of pooling or dilated convolution strategy, thus they typically go through some form of subsampling operation followed by a supersampling operation.", "In the optimization based framework, the feedforward pass is a subsampling pyramid operation as higher order features are extracted deeper in the network, then the generation of the new image is a supersampling process through backpropagation as gradients traverse upwards through the network to the higher resolution shallow layers.", "In a feedforward architecture, many approaches are typically some form of auto-encoder or cascading image pyramid, both of which utilize some form of subsampled data and attempt to supersample it during the synthesis process.", "In many embodiments of the invention, network architectures designed for image synthesis, which may rely on pooling or strided convolution to do downsampling, can be improved by using a dilated convolution architecture instead.", "Therefore, the system in accordance with several embodiments of the invention makes use of dilated alternatives to such network architectures, as dilation is often a superior form of downsampling for image synthesis operations.", "In addition, where a synthesis strategy also relies on the use of image pyramids (typically Gaussian pyramids) of the input data for additional multiscale synthesis, the system in accordance with some embodiments of the invention uses an image stack to replace the image pyramid (typically a Gaussian stack).", "The dilated network strategy is particularly well suited for auto-encoders where the decoder network is a layer-wise inverter of the encoder network (i.e.", "each layer in the encoder has a “mirror” layer in the decoder which inverts that layer as accurately as possible).", "This particular network architecture is desirable for fast image synthesis because the encoder side of the network can distill an image into its most meaningful features, which can be modified in some way by another algorithm (e.g.", "including, but not limited to, a whitening transform, histogram match, or nearest neighbor search).", "The newly updated values can then be inverted by the decoder in order to produce a new image.", "This synthesis strategy is attractive because it's much faster and more memory efficient than an optimization based approach.", "It is however very difficult to implement because inverting a network that includes pooling is very difficult (historically literature has always used a pre-trained VGG network as the encoder).", "Inverting pooling layers typically leads to blurring or other such supersampling artifacts.", "Systems in accordance with many embodiments of the invention implement a dilated architecture as an alternative, which is easy and more accurate to invert on a layer-by-layer basis.", "In many embodiments, a whitening transform, multiscale NNS search or histogram matching algorithm can continue to be applied to features at each network layer as they progress through the decoder.", "Note that dilation shares the same drawback as the image stacks, it is a memory inefficient way to encode data, especially deeper in the network.", "Previous texture synthesis approaches utilizing image stacks were generally limited to 256×256 pixels in resolution due to the high memory demands.", "However, conventional images may have much higher pixel resolutions (e.g., up to or exceeding a 8192×8192 pixel resolution).", "The size of these images can make the image stack representation too memory demanding.", "Instead, processes in accordance with some embodiments of the invention combine pooling or strided convolution layers at the shallow end of a convolutional neural network architecture with dilated convolution layers deeper in the network.", "This “hybrid” network architecture exhibits the properties of a pyramid network up to a specific depth in the network and then switches to the properties of a dilated stack.", "From a memory viewpoint, this is attractive because large images quickly get condensed into much smaller images for the majority of the network.", "This is also a good compromise from an image processing viewpoint because the deeper layers of the network encode the complex shapes and patterns and thus need the highest resolution.", "Shallow layers of the network only encode simple shapes and textures and don't require the same degree of network capacity.", "This new network architecture can be visualized as an image stack with a pyramid sitting on top of it.", "Although a specific pyramid-stack hybrid convolutional neural network architecture based on some combination of pooling, strided convolution and dilated convolution is used for image synthesis in a number of examples discussed above, in several embodiments of the invention, the pyramid-stack hybrid may be modified in a variety of ways, including (but not limited to) adding, removing, and/or combining components of the stack.", "Image Hybridization Starting from a set of several source images within the same category, systems and methods in accordance with many embodiments of the invention can hybridize, or mix them together in a way that produces a new member from that category.", "This is a follow-up work to Risser, Eric, et al.", "“Synthesizing structured image hybrids.” ACM Transactions on Graphics (TOG).", "Vol.", "29.No.", "4.ACM, 2010.the disclosure of which is hereby incorporated by reference in its entirety.", "While this work is based on the same theories as the original approach, this version of image hybridization is re-designed from the ground up in order to utilize convolutional neural networks both for image description and as the machinery for performing synthesis.", "The three key observations for image hybridization are: (1) instead of taking a small sample from an infinite plane of texture and synthesizing more of that infinite plane, grab a small sample across an infinite set within a “category” and synthesize more instances of that category, (2) structure exists across scales and should be observed across scales, and (3) manifesting structure from noise is difficult, so don't break structure in the first place.", "CNN based image synthesis is an ideal approach for hybridizing images due to the CNN's ability to learn and identify complex shapes and structures across multiple scales.", "Unlike other image synthesis methods which can be improved by dilated convolution, but do not require it, hybridization is likely to produce poor results and artifacts if deeper layers of the CNN are subsampled.", "Therefore, the input images can be passed in a feedforward manner through a dilated convolutional neural network to produce deep neural activations that have a 1-to-1 mapping with input image pixels.", "The logic behind using a stack as opposed to a pyramid is that when performing coarse to fine synthesis, the texture built at a coarse level largely influences whether a local or global minimum will be found.", "When a sub-optimal choice is made at the coarse level of the synthesis pyramid, synthesis will get stuck in a local min, so it is important to be very careful when synthesizing at the coarse level, in order to achieve a good result.", "When doing stochastic texture synthesis, there are many local mins that are all very similar to the global min, so this is less of a concern.", "When doing image hybridization though, most local minima are significantly worse than the global minimum and a small set of local minima surrounding the global minimum.", "This can be tied to breaking versus preserving the global structure of the image.", "The reason why stacks typically preserve global structure as opposed to pyramids is very simple.", "Imagine the same picture of a face in image A and image B.", "The only difference is that image B is transposed along the x axis.", "When turning A and B into pyramids, the right eye is subsampled into a single pixel at a coarse level.", "The same eye in image B, however, is spread across two pixels which also have features surrounding the eye, thanks to the transposed position drastically changing the quantization in the pyramid.", "When synthesizing the texture at a coarse level, there are no good nearest neighbor matches between image A and B, the center of the eye is represented by a pixel in image A but image B only has the right and left sides of the eye as candidates to be linked to.", "While it's theoretically possible to recover the eye feature at finer levels, this is a much harder problem and in practice rarely happens.", "By using a stack, the system in accordance with many embodiments of the invention avoids quantization and maintains the maximum number of features to compare, drastically increasing the chance of finding good matches.", "To bootstrap the synthesis process, choose one of the input images at random and pass it feedforward through a network.", "Unlike the first step that extracts feature vectors for each exemplar, synthesis itself does not strictly require a dilated architecture.", "Dilated versus strided convolution have their own benefits and weaknesses and are compared below.", "The important thing to note is that the same convolution kernels used for extracting exemplar features typically must also be used during synthesis.", "Luckily, a dilated architecture can be thought of as a collection of pyramid architectures, so the same set of kernels can be used in either strategy.", "Many of the examples described herein refer to VGG-19 feature kernels pre-trained on the ImageNet dataset, however one skilled in the art will recognize that convolutional kernels from any network architecture trained on any dataset may be applied in accordance with various embodiments of the invention.", "Hybridization, unlike other image synthesis operations, is a non-parametric process that relies on finding similar matching features between input and output images and building new images by re-combining sets of exemplar features into new configurations while tracking the global feature error between these new features being mixed and the original input features that they were derived from.", "Note that hybridization can be performed in either an optimization or feedforward based synthesis strategy.", "In either case, the key aspect of image hybridization is to algorithmically generate new activations at different levels of the network which combine the activation features extracted from the input images into new hybrid configurations.", "Before we describe how these new hybrid configurations are generated, we'll identify how they are used to synthesize new images.", "When performing optimization based synthesis, an input image (typically noise, but it could be anything) is iteratively updated to minimize some loss function.", "The “hybrid loss” function is the summed L2 distance between each pixel in the current image being synthesized and the hybrid activation maps at a given layer.", "This is the same strategy as the “content loss” described above, however, whereas the content loss was taken directly from an input image, the “hybrid loss” is a new activation map that is generated by recombining activation features taken from different input images.", "In the original image synthesis work, content loss is only used at RELU4_1, so that it does not overpower style loss at shallow layers of the network.", "Hybridization in accordance with a number of embodiments of the invention incorporates a style loss in order to perform style transfer combined with hybridization all in one operation.", "Alternatively, in several embodiments, the basic hybridization algorithm assumes that there is no style loss.", "Therefore, hybrid loss can be used at multiple layers in the network.", "Feedforward networks on the other hand do not perform an optimization process turning one image into another, instead they transform an image into a new image.", "Therefore, using the dilated auto-encoder network described above, the encoder portion is run on all input images, their features are hybridized in the middle of the network using another process, and then this hybridized set of activation values are inverted by the decoder.", "Note that in both optimization and feedforward synthesis, the results of hybridizing deep features in the network can be passed up to shallow layers and then become further hybridized through another hybridization step.", "In order to describe the process in which activation maps are reconfigured to produce hybrid activation maps, it is helpful to first introduce the concept of feature space.", "The idea behind feature space is that similar visual features in the image will map to points in feature space that are close to each other in terms of Euclidean distance, while very different looking features will be very far away from each other.", "The neural network in accordance with some embodiments of the invention is a feature descriptor and converts a neighborhood of raw pixel values into a single point in a high dimensional feature space.", "Given this background, the creation of hybrid activations for a layer can be explained.", "Given the layer activations for one of the random input images, the goal is to traverse every pixel location in the layer and replace the current feature vector at that location with a new feature vector taken from some other pixel location in that layer or from some pixel location taken from another input image's neural activations at that layer.", "This can be done through a two-step process where the process introduces randomness or “jitter” and then “corrects” any artifacts or broken structures caused by the jitter.", "In certain embodiments, the process optionally pre-computes k-nearest neighbors between each input image and every other input image as a part of an acceleration strategy.", "In the next phase, for each pixel in the image being synthesized, the process in accordance with many embodiments of the invention gathers k nearest neighbors from the input exemplars.", "In certain embodiments, the process divides up the k samples equally across all the exemplars.", "In a number of embodiments, the distance metric used for these KNNs is the L2 distance between feature vectors at the neural network layer of interest.", "This is equivalent to transforming all of the image data into points in high dimensional feature space.", "Around each synthesis feature point, the process in accordance with some embodiments of the invention gathers the cluster of exemplar feature points surrounding it, such that the process samples the same number of points from each exemplar.", "The next step is to sort these K nearest neighbors from smallest to largest distance.", "In certain embodiments, the one parameter exposed to the user is a “jitter slider” that goes from 0-1 (or an equivalent linear or non-linear range), where 0 should produce one of the original inputs and 1 should be the maximum hybridization and mutation.", "Therefore, the 0-1 range is mapped to the min distance and max distance of the closest to farthest neighbors.", "Depending on the jitter setting, the process in accordance with many embodiments of the invention gathers the K nearest neighbors with distances less than the jitter value and randomly selects one of them to update the synthesis patch with.", "This is akin to constraining noise.", "Instead of starting from noise and trying to recover structure from it (which is very difficult), instead the process in accordance with a number of embodiments starts from pure structure (i.e.", "the input) and adds noise strategically and intelligently in order to not break the structure to a degree from which it cannot be recovered.", "To this end, the process in accordance with several embodiments of the invention adds noise or randomness in “feature space” rather than color space or image space as is typical for these types of algorithms.", "This strategy adds noise in feature space, which essentially allows the process to randomize the image in a way that preserves the important structures of the image.", "This operation can be performed at one or more convolution layers within the CNN.", "After jitter is used to modify the details of the new image being synthesized, the second step “correction” then “fixes” the image so that it maintains statistical similarity to the exemplar input.", "For each n×n neighborhood of synthesized neural activation vectors (where n×n could be any size, including 1×1 e.g.", "a single element vector), correction seeks out the neighborhood of neural activation vectors in any exemplar that has the lowest L2 distance.", "The current synthesis neural activation vector is then replaced with that closest exemplar neural activation vector.", "The correction scheme is based on coherence (Ashikhmin, Michael.", "“Synthesizing natural textures.” Proceedings of the 2001 symposium on Interactive 3D graphics.", "ACM, 2001—the relevant disclosure from which is hereby incorporated by reference in its entirety), which states that nearest neighbor selection is not always the best method for finding perceptual similarity.", "Rather coherence, or the relationship between neighboring pixels, plays a large role in structure and perceptual similarity.", "Therefore, the process in accordance with many embodiments of the invention introduces a bias so that exemplar activation vectors that form a coherent patch with the surrounding synthesis activation vectors are given a reduction in L2 distance.", "This incentivizes the formation of coherent patches from the exemplar.", "For both jitter and correction, the process in accordance with various embodiments of the invention can either perform a nearest neighbor search from the synthesis layer to the exemplar layers during runtime of the algorithm, or could pre-compute a candidate list of k-nearest neighbors from every exemplar feature to every other k exemplar feature.", "Then, during synthesis, each activation vector also maintains a pointer to the exemplar activation vector that it is mimicking.", "Whether pre-computing nearest neighbors, or finding them at runtime, a nearest neighbor searching algorithm that is designed with neural networks in mind is needed.", "To this end, several embodiments in accordance with the invention use a nearest neighbor algorithm as described in U.S.", "Provisional Application 62/528,372, entitled “Systems and Methods for Providing convolutional Neural Network Based Non-Parametric Texture Synthesis in Graphic Objects, filed on Jul.", "3, 2017, the disclosure of which is incorporated herein in its entirety.", "The synthesis process for an optimization based algorithm in accordance with some embodiments of the invention runs E input images through a dilated version of a CNN, resulting in a set of activation vectors for specific layers of interest (for the sake of VGG-19, these are RELU1_1, RELU2_1, RELU3_1 AND RELU4_1).", "The synthesis process runs a randomly selected input image through either a dilated or un-dilated version of the CNN to produce the starting point for the hybrid activations.", "The process runs a jitter pass and runs the standard neural optimization based synthesis method starting from some prior (typically noise) for several iterations of backpropagation until the prior has turned into a manifestation of the jittered activations at the deep layer.", "The process then runs a correction pass on the activations at the coarsest layer in the network (for VGG-19, this is RELU4_1), thus producing the hybrid activations for that layer.", "The process runs the standard neural optimization based synthesis method again for several iterations of backpropagation until the prior has turned into a manifestation of the hybrid activations at the deep layer.", "Once the current level has converged, the process moves to the next most shallow layer of interest in the network (e.g.", "RELU3_1 for VGG-19) and repeats the process, jitter and correct in order to find new hybrid activations for that layer to use as the target for hybrid loss and reruns the optimization process now only going to that layer and no farther down the network.", "Repeat this process until the shallowest layer of interest is optimized.", "The synthesis process for feedforward networks in accordance with a number of embodiments of the invention runs all inputs through the encoder, producing the deep neural activations.", "Before running the decoder, the process runs the jitter pass on one of the exemplars in order to randomize the features.", "In order to correct, the process samples a neighborhood of activation vectors (at least 3×3) around each activation vector and performs the correction phase of the algorithm.", "The jitter and correction phase can either use pre-computed nearest neighbor sets or run a full nearest neighbor search during the algorithm.", "Once correction is finished, the process continues through the decoder, inverting the new hybrid layer.", "This process can be repeated for each layer moving through the decoder or only run at target layers.", "This is a tradeoff between algorithm speed and the scale at which features are hybridized.", "Optimization based synthesis is slower than feedforward, however it achieves superior quality.", "On Model Image Synthesis Using Convolutional Neural Networks In computer graphics, a 3D model is typically “texture mapped”.", "For purposes of this discussion, “texture mapped,” means an image is wrapped over the surface of the 3D shape as shown in FIG.", "24.3D models typically contain UV coordinates at each vertex which define the 2D parameterization of the 3D surface.", "In FIG.", "24, the left image displays the underlying geometry of the mesh 2401, the middle image shows the geometry with a texture mapped over the mesh 2402 and the image on the right shows what that texture 2403 looks like as a 2D mapping of a 3D surface.", "We refer to synthesizing texture maps as “on-model synthesis.” Processes in accordance with many embodiments of the invention integrate an on-model synthesis approach into the CNN approach.", "To do so, these processes have to spread out atlas maps and build a gutter space of pointers re-directing to neighboring charts.", "The CNN based synthesis approach in accordance with many embodiments of the invention relies on the process of convolution in which each pixel of the synthesis kernel is filtered based on a neighborhood of its surrounding pixels.", "On-model synthesis introduces two complications on top of the standard synthesis approach in image space: (1) Flow field over a 3D model is generated using its curvature properties along with user guidance.", "That flow field can then be projected as a 2D vector field in the parameterized texture space.", "This flow field typically contains both directional components as well as scale components along each axis.", "Rather than convolving the neural network along the image x and y axis unit vectors globally, each pixel now has its own local coordinate frame and scale.", "(2) Because an arbitrary 3D surface cannot be mapped to a single plane, UV texture space is typically broken up into a set of “charts” where each chart covers a relatively flat portion of the model.", "This adds another level of complication because texture colors that are coherent along the surface of the model are not coherent in texture space where we perform our convolutions.", "To accommodate this, the process in accordance with many embodiments of the invention adds a gutter space of a few pixels in radius around each chart.", "These gutter pixels store pointers to other charts in texture space that encode coherent pixels along the model's surface.", "This additional pointer buffer is referred to as a “jump map”.", "When performing convolution, rather than sampling directly from the image, the process in accordance with a number of embodiments first samples from the jump map which points to the image pixel that should be sampled.", "Because texture space might have tightly packed charts, as a pre-process, the process in accordance with some embodiments spreads out the charts so that there is a gutter space of at least two pixels around each chart at the coarsest synthesis pyramid level plus however many pooling layers are passed through in the CNN.", "Note that when using dilated convolution, the gutter space typically must be two to the power of the number of dilated convolutions.", "Processes in accordance with some of these embodiments introduce an underlying vector field that frames the local orientation around each pixel.", "As CNNs work by performing convolution across an image, the vector field directs the local orientation of the convolution.", "Thus, these processes can bi-linearly interpolate sampling of neural activations from the previous layer.", "Where the convolution kernel extends beyond the scope of an atlas chart, the gutter space of pointers redirects to another atlas chart.", "During the back-propagation phase of the process, inverse mapping can be used in a manner similar to what is described above with respect to convolution.", "This allows these processes to perform CNN image synthesis directly in UV space for on-model synthesis.", "Thus far the algorithm described is designed to use a rectangular texture and a single model (with no relationship between the two) as input and synthesize a new image which maps into the model's unwrapped texture space, as shown in the FIG.", "25, where texture 2501 is wrapped around mesh 2502.In this regard the input is still a rectangular image and the output uses the mesh as a canvas on which to paint over.", "In many instances, a pre-textured mesh is given as input and the textures already parameterized into some UV space are used as the source data to feed an image synthesis process.", "Processes in accordance with some embodiments of the invention follow a similar approach.", "These processes take this concept a step further and produce textures that conform to geometric shapes and the feature contents of that texture are guided by the underlying shape itself.", "This results in image synthesis that can be applied on top of already textured meshes, and can also produce appearance transfer from one textured mesh onto another.", "The goal of processes in accordance with some embodiments of the invention is to go one step further and provide an on-model texture synthesis scheme that allows the user to supply a fully textured model as the input exemplar (for example texture mapped mesh (2402)) instead of just a texture (2403), and apply that texture from the model onto a different untextured model.", "The advantage to this approach is that a lot of useful information is represented by a textured mesh, including (but not limited to) the relationship between varying texture features and the underlying geometric shape on which they would typically exist.", "Texture and shape are often not independent.", "Instead, texture and shape are related.", "Thus, by learning or associating the relationships between a texture and a shape to which the texture is applied, processes in accordance with some embodiments of the invention can provide artists with more powerful and convenient tools.", "There are two key ideas behind this approach in accordance with some embodiments of the invention.", "The first is that deep neural activation features and their resulting parametric models for UV mapped textures should be calculated using the same vector field and jump map approach proposed above for the purposes of synthesis.", "The second is to find a shape descriptor that is both effective as well as compatible with an image descriptor maintained by the system and the image based GPU accelerated framework upon which the system is built.", "A key insight is that geometric shape information can be projected onto an image (i.e.", "a regular grid) and the shape descriptor is able to work by sampling patches from this grid in order to maintain compatibility with the GPU framework.", "Because it is desirable that geometric neighborhoods correspond to texture neighborhoods, it makes sense that the geometric projection into image space should match the texture unwrapping.", "The only issue is that texture information can map to multiple portions of a single mesh.", "As such, processes in accordance with some embodiments of the invention utilize a texture parameterization that provides a 1-to-1 mapping between points on a model and pixels in a texture image.", "This amounts to simply making copies of charts or chart regions that are pointed to from multiple polygons so that each polygon maps to its own region in texture space.", "Once each point on the 3D surface of a mesh points to a unique pixel in image space, any arbitrary shape description, ranging from point location in 3D space to more sophisticated descriptors, can be fed into a CNN framework in order to learn local shape features using a CNN training process.", "One such training approach could be mesh categorization, however, other training approaches such as mesh compression, feature clustering or upres could also be viable training strategies for learning meaningful shape features.", "Condensed Feature Extraction Networks In several embodiments, a learning strategy for condensing networks that have been trained for purposes other than image synthesis allows for the production of new networks that are more efficient at extracting image features used for image synthesis.", "Typically, VGG-19 pre-trained for image classification is used as a high quality, learned image descriptor for extracting out meaningful image features for the purposes of image synthesis.", "Many networks designed for classification have been designed for a different and more difficult problem than texture feature extraction and often require more capacity than is needed for feature extraction.", "VGG, for example, is computationally expensive to run, which can result in small images, long wait times and a reliance on expensive hardware.", "One of the benefits of systems in accordance with various embodiments of the invention is to improve memory/speed performance, without sacrificing synthesis quality.", "Again, for the purposes of image synthesis, VGG or some other network architecture trained on classification can be of interest on the basis that the kernels that were produced as a byproduct of the learning process for image classification can be useful in image synthesis.", "For image synthesis, not all activation maps produced by a network are needed, only a small subset of those feature maps.", "As such, there are layers in the network that are not used directly for image synthesis, rather blocks of layers are run between layers of interest.", "In many embodiments, the number of hidden layers in a previously trained CNN can be reduced and/or the capacity of those hidden layers can be reduced.", "The simplest strategy is to train a new network on image classification.", "Unfortunately, if a new set of kernels for classification on a lower capacity network is learned, there's a good chance that there won't be enough capacity to perform classification as well as VGG and if the classification isn't as good then the resulting kernels might not do as good a job at feature extraction.", "Rather than learning a leaner feature extraction network by reproducing the classification learning process, the learning strategy in accordance with many embodiments of the invention uses the activation maps produced by VGG (or some other artificial neural network) as the ground truth (since they will produce good synthesis results) and a network is trained to try and reproduce the input/output pairings using fewer neurons then VGG.", "The assumption behind this condensed network learning strategy is that a reduction in network capacity has a larger effect on the quality of classification performance than it does on feature extraction for the purposes of image synthesis.", "For example, if a small network approximates a VGG convolutional block at 95% accuracy at 25% VGG's neurons, that would introduce so much error that the classification results would be dramatically affected.", "However, for the purposes of image synthesis, 95% accuracy would still find very good image features and synthesis quality would not be noticeably effected.", "Stated another way, systems and methods in accordance with many embodiments of the invention utilize an artificial neural network with a specific number of neurons to learn a network that approximates the intermediate neural activations of a different network with a larger number (or the same number) of artificial neurons for the purposes of efficient image synthesis.", "Although various processes for generating a geometric description map for convolutional neural network based texture synthesis are discussed above, many different systems and methods can be implemented in accordance with various embodiments of the invention.", "It is therefore to be understood that the present invention may be practiced in ways other than specifically described, without departing from the scope and spirit of the present invention.", "Thus, embodiments of the present invention should be considered in all respects as illustrative and not restrictive.", "Accordingly, the scope of the invention should be determined not by the embodiments illustrated, but by the appended claims and their equivalents." ] ]
Patent_15876011
[ [ "PIPELINED VIDEO DECODER SYSTEM", "Efficient decoding of video content that may involve intra block copy operations, such as copying pixel data from one region of a frame to another region of the same frame is described.", "For example, a method to decode the video content may involve identifying the video frame in which intra block copy operation is to be performed, prior to the intra block copy operation being initiated.", "A video decoder may prefetch the pixel data from the source region to a local buffer with low memory latency such that the source pixel data to be copied into the destination blocks in the video frame is readily available.", "Thus, costly, and time consuming memory access may be avoided, and in turn a video decoding pipeline may operate smoothly without any stalling." ], [ "1.A device comprising: at least one circuit configured to: decode a current block within a frame of video data, the frame comprised of a plurality of blocks; identify an intra-block copy request (IBC request) for the current block, wherein the IBC request comprises copying content from a source block to the current block of the frame, wherein the source block is within the frame and has been decoded; and copy the content of the source block to the current block.", "from the internal memory 2.The device of claim 7, wherein memory latency of the internal memory is lower than memory latency of the external memory.", "3.The device of claim 1, wherein the at least one circuit is further configured to: pre-fetch the content of the source block prior to completion of decoding of the current block.", "4.The device of claim 1, wherein the at least one circuit is further configured to filter decoded blocks of the video data.", "5.The device of claim 4, wherein, an internal memory is configured to store a predetermined number of decoded blocks within the frame of the video data, the frame being currently decoded by the device.", "6.The device of claim 5, wherein the predetermined number of decoded blocks stored within the internal memory are stored prior to a block copy operation of the device.", "7.The device of claim 6, wherein the decoded blocks, prior to the block copy operation, are further stored in an external memory.", "8.A method comprising: receiving, using at least one circuit, a frame, the frame divided into a plurality of blocks; decoding, using the at least one circuit, a block from among the blocks of the frame; and decoding, using the at least one circuit, another block from among the blocks of the frame, the decoding the another block comprising copying contents of the decoded block of the frame as decoded contents of the another block, wherein the block is different than the another block.", "9.The method of claim 10, further comprising: storing, using the at least one circuit, at least a part of the decoded block of the frame, prior to filtering, in a local buffer.", "10.The method of claim 8, further comprising: filtering, using circuitry, the decoded block of the frame; and storing, using circuitry, the filtered block of the frame in a memory storage device, for display.", "11.The method of claim 9, wherein, copying the contents of the decoded block comprises copying at least part of the contents of the decoded block from a memory storage device.", "12.The method of claim 11, wherein, copying the contents of the decoded block further comprises copying at least part of the contents of the decoded block from the local buffer.", "13.The method of claim 8, wherein the received frame is received from a source device for screen casting.", "14.A computer program product comprising code stored in a non-transitory computer-readable medium, the code comprising: code to receive video data, the video data comprising a plurality of video frames, each video frame of the video frames further comprising blocks of pixels; code to decode a first block of pixels; code to identify an intra block copy instruction associated with decoding a the second block of pixels; and code to, in response to the intra block copy instruction, copy part of the decoded first block of pixels to the second block of pixels.", "15.The computer program product of claim 14, wherein the intra block copy instruction identifies the first block of pixels as a source of contents for the second block of pixels.", "16.The computer program product of claim 15, wherein the code further comprises: code to filter the decoded first block of pixels; and code to store the filtered first block of pixels for display.", "17.The computer program product of claim 15, wherein the code further comprises: code to, in response to the intra block copy instruction, copy part of a decoded third block of pixels to the second block of pixels, wherein the intra block copy instruction further identifies the third block of pixels as another source of contents for the second block of pixels.", "18.The computer program product of claim 14, wherein the code further comprises: code to parse the intra block copy instruction to determine one or more source blocks for the intra block copy instruction for the second block of pixels, wherein contents of the one or more source blocks are copied into the second block of pixels; code to identify one or more locations of the one or more source blocks for the intra block copy instruction; and code to copy contents from the one or more source blocks from the identified one or more locations into the second block of pixels.", "19.The computer program product of claim 18, wherein: the first block of pixels is identified as a source block for the intra block copy instruction and a location of the first block of pixels is identified as a first memory device; and a third block of pixels is identified as another source block for the intra block copy instruction and a location of the third block of pixels is identified as a second memory device that has a higher latency than the first memory device.", "20.The computer program product of claim 19, wherein the code further comprises: code to identify the one or more locations of the one or more source blocks for the intra block copy instruction based on a predetermined number of blocks of pixel stored in the first memory device." ], [ "<SOH> BACKGROUND <EOH>Rapid advances in electronics and communication technologies, driven by immense customer demand, have resulted in the worldwide adoption of devices that display a wide variety of video content.", "Examples of such devices include smartphones, flat screen televisions, and tablet computers.", "Improvements in video processing techniques will continue to enhance the capabilities of these devices.", "Accordingly, coding of screen content video is becoming important because of applications such as wireless displays, remote desktop, remote gaming, automotive infotainment, cloud computing, distance education and many others." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>FIG.", "1 illustrates a block diagram of an example video decoder.", "FIG.", "2 illustrates an example intra block copy operation.", "FIG.", "3 illustrates an exemplary video decoder.", "FIG.", "4 illustrates example memory access cases during video decoding.", "FIG.", "5 illustrates an example video decoder.", "FIG.", "6 illustrates an example video decoder.", "FIG.", "7 illustrates exemplary steps performed when processing an example frame FIG.", "8 illustrates a flowchart of example steps performed by an example video decoder.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "PRIORITY CLAIM This application claims priority to provisional application Ser.", "No.", "61/979,255 filed Apr.", "14, 2014, which is entirely incorporated by reference.", "TECHNICAL FIELD This disclosure relates to video decoding and particularly to pipelined video decoding techniques.", "BACKGROUND Rapid advances in electronics and communication technologies, driven by immense customer demand, have resulted in the worldwide adoption of devices that display a wide variety of video content.", "Examples of such devices include smartphones, flat screen televisions, and tablet computers.", "Improvements in video processing techniques will continue to enhance the capabilities of these devices.", "Accordingly, coding of screen content video is becoming important because of applications such as wireless displays, remote desktop, remote gaming, automotive infotainment, cloud computing, distance education and many others.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates a block diagram of an example video decoder.", "FIG.", "2 illustrates an example intra block copy operation.", "FIG.", "3 illustrates an exemplary video decoder.", "FIG.", "4 illustrates example memory access cases during video decoding.", "FIG.", "5 illustrates an example video decoder.", "FIG.", "6 illustrates an example video decoder.", "FIG.", "7 illustrates exemplary steps performed when processing an example frame FIG.", "8 illustrates a flowchart of example steps performed by an example video decoder.", "DETAILED DESCRIPTION Video content is encoded using various encoding techniques and standards such as MPEG-1, MPEG-2, H.264, H.265, and many others.", "The H.265 standard is also referred to as High Efficiency Video Coding (HEVC).", "The encoding techniques may be used to compress video content for efficient transmission over wired or wireless networks.", "The compression may involve predicting pixel values based on video content that may be used as reference video content.", "For example, spatial prediction may be performed to predict pixel values based on immediate neighboring pixels in a video frame.", "In addition, or alternatively, temporal prediction may be performed in which pixel values are predicted based on corresponding pixel values in previous or subsequent frames.", "Additional operations may be performed when the video content being transmitted is screen content.", "Screen content sharing may involve sharing, or transmitting content being displayed on one display device, or screen, to another display device or screen.", "Alternatively, content may be transmitted from a source device without display capability to a display device.", "For example, wireless screen sharing from mobile devices to large screens may enable displaying video content being displayed on a mobile device, such as a phone, tablet, or a computer to a large screen, such as a television (TV) or projector.", "For example, technologies such as Miracast, Apple AirPlay, or Chromecast may be used.", "Additionally, or alternatively video content may be shared between a set-top box and a TV.", "Further yet, the content may be communicated and shared via a wired transmission.", "The video content being shared may have mixed content consisting of video, text and graphics in the same picture.", "Further, the shared video content may include camera captured content and computer generated content such as text and graphics.", "For example, during a video conference, camera captured content, such as an image of a presenter may be shared along with contents being displayed on a device being used by the presenter, such as a computer with a presentation slides or other such content.", "In one exemplary scenario the source device may decode the content before transmitting to the display device.", "Alternatively, the shared video content may be decoded at a receiver to display the contents.", "The video content may be decoded on a macroblock-by-macroblock basis.", "FIG.", "1 illustrates a block diagram of an example video decoder 100.A video decoder may also be referred to as a stream parser, or simply a decoder.", "The video decoder 100 may include circuitry to perform various functions.", "For example, the video decoder 100 may include circuitry for a symbol decoder 110, a spatial mode generator 120, coefficient generator 130, vector generator 140, inverse transformer 150, temporal predictor 160, spatial predictor 170, loop filter 180, and a memory storage unit 190.Other examples of video decoders may include circuitry that performs operations of a combination of more than one of the above listed components of video decoder 100.Alternatively, or in addition the components of the video decoder 100 may use additional circuitry, such as one or more processors.", "The memory storage unit 190 may be a computer readable storage medium, such as random access storage memory (RAM) for example dynamic random access memory (DRAM).", "The memory storage unit 190 may contain data that is used by the components of the video decoder 100 to decode video content.", "The video content to be decoded may be received by the video decoder 100 and may be stored in the memory storage unit 190, for example in the coded data buffer 192.The data stored in the coded data buffer 192 may involve a raw video stream that is generated after completion of steps such as finding start code, byte destuffing, and other preliminary analysis of the received video content.", "The received video content, which may be received as a video stream, may comprise video data encoded according to one or more of a plurality of encoding standards, such as H.261, H.263, H.263+(Annex J), H.264, VC-1, MPEG-1, MPEG-2, MPEG-4, and/or H.265, for example.", "The video decoder may be adapted to detect one or more start codes and start code suffixes, to determine the encoding type and generate the raw video content in the video stream.", "The memory storage unit 190 may also contain reference data that may be used during the decoding, such as in the reference picture buffers 196.The data in the reference picture buffers may be stored by the components of the video decoder 100, before, after or during the decoding process.", "The symbol decoder 110 may also be referred to as a symbol interpreter.", "The symbol decoder 110 may receive or access the video content stored in the memory storage unit 190.Alternatively, or in addition, the symbol decoder 110 may receive the video content to be decoded via a communication interface, such as a communication port.", "The symbol decoder 110 may decode/interpret received content, such as, for example, single syntax elements from the video content that were encoded utilizing fixed length coding (FLC), variable length coding (VLC) or Context-Adaptive Binary Arithmetic Coding (CABAC) coding techniques.", "The video content may be divided into frames with each frame further composed of blocks (macroblocks) of pixels.", "The spatial mode generator 120 may determine prediction mode to be used by the temporal predictor 160 and/or the spatial predictor 170.The prediction mode, for example, and among other factors may indicate size of the macroblock partition used during prediction by the predictors.", "The coefficient generator 130 may generate one or more quantized frequency coefficients from the video content.", "Quantized frequency coefficients generated by the coefficient generator 130 may be subsequently utilized within the video decoder 100 to generate prediction error information utilized during reconstruction of one or more macroblocks, or blocks of the video content.", "The generated quantized frequency coefficients may be communicated to the inverse transformer 150 for further processing.", "The vector generator 140 may be adapted to generate one or more motion vectors from the video content.", "The motion vectors generated by the vector generator 140 may be utilized within the video decoder 100 to generate prediction pixels utilized during reconstruction of one or more macroblocks.", "The generated motion vector information may be communicated to components responsible for other functions, such as motion compensation, for further processing.", "The inverse transformer, or inverse quantization transformer (IQT) 150 includes suitable circuitry, logic and/or code to transform quantized frequency coefficients received from the symbol interpreter 110 into one or more prediction errors.", "The IQT 150 may transform the quantized frequency coefficients back to spatial domain, thus generating prediction error information.", "The prediction error information generated by the IQT 150 may then be communicated to the other components of the video decoder 100 for further processing during reconstruction of a macroblock.", "The temporal predictor 160 may involve suitable circuitry, logic and/or code to generate prediction pixels utilizing motion vector information received from motion vector generator 140.For example, the temporal predictor 160 may generate prediction pixels for temporally predicted macroblocks, which may be associated with pixels in frames/fields neighboring a current frame/field.", "The temporal predictor 160 may acquire previous and/or subsequent frames/fields from the reference picture buffers 196 and utilize the acquired previous and/or subsequent frames/fields for predicting temporally encoded pixels within a current macroblock.", "The reference picture buffers 196 may also be referred to as frame buffers.", "The temporal predictor 160 may be further adapted to interpolate one or more prediction pixels within a current frame utilizing motion vector information, as well as one or more reference frames that are temporally adjacent to the current frame.", "Further, prediction pixels may be interpolated utilizing only one reference frame or more than one prediction reference frame, during the temporal prediction of a current frame.", "The temporal predictor 160 may include separate circuitry to handle the bi-directional prediction that may be utilized to generate the prediction pixels from more than one reference frame.", "The spatial predictor 170 may involve suitable circuitry, logic and/or code to generate prediction pixels.", "The prediction pixels may be generated from neighboring pixels in the same frame.", "The spatial predictor 170 may also contain a reconstruction block (not shown) to add the prediction and the prediction error to generate a decoded macroblock.", "The spatial predictor 170 acquires macroblock type information, slice type information and/or prediction mode information, for example, from the symbol interpreter 110 and the spatial mode generator 120.The spatial predictor 170 may then utilize the acquired macroblock type information, slice type information and/or prediction mode information to generate prediction pixels for spatially predicted macroblocks.", "The loop filter 180 may include suitable circuitry, logic and/or code to further filter a decoded/reconstructed macroblock.", "Depending on the encoding method of the video content, the loop filter may use a deblocking filter.", "The deblocking filter may be utilized by the loop filter 180 to reduce edge artifacts and transform blockiness effects along one or more edges of a reconstructed macroblock.", "The video decoding performed by the video decoder 100 can thus be performed in a deterministic pipelined structure.", "The memory fetches performed during the decoding are pre-determined.", "For example, prior to processing video frame data received by the video decoder 100, components of the video decoder 100 may initiate memory access to retrieve data that may be used for the processing.", "For example, the vector generator 140, may identify and determine reference blocks to be used for the temporal prediction that needs to be performed for the received video frame.", "Accordingly, before the temporal predictor 160 begins the actual process of temporal prediction, the temporal predictor 160 may fetch the reference frames to be used for processing the video frame.", "Further, while the temporal predictor is performing the temporal prediction, the spatial predictor 170 may identify the data that may be used for spatial prediction and overlap a memory access required to retrieve the data with the temporal prediction operation.", "As such, memory latency may be hidden by overlapping the memory fetch operations with operations of the decoding process.", "In addition, or alternatively, video content sharing, such as screen content sharing may use Intra block copy (IBC) when encoding and decoding the shared video content.", "IBC may involve a block matching technique in which a Coding Unit (CU) may be predicted as a displacement from already reconstructed block of samples from neighboring regions in the same frame, or picture.", "FIG.", "2 illustrates an example intra block copy.", "The intra block copy is being performed on a frame 200.The frame 200 is an image.", "The image may be a stand-alone image or a part of a video content stream.", "The frame 200 may be divided into various blocks, including blocks that are already decoded 210 and blocks that are yet to be decoded 240.Block 220 is currently being decoded.", "The encoded video content stream indicates that the contents of the block 220 may be copied from content of the blocks that are already decoded 210.FIG.", "2 illustrates that block 220 may be decoded, by copying contents of the block 230, that is block 230 is a source block and block 220 is a destination block.", "It will be understood that various other combinations of source and destination blocks are possible, including source blocks 230 which do not align with blocks already decoded 210; some possible exemplary situations are detailed throughout this disclosure.", "FIG.", "3 illustrates an exemplary video decoder 300 with circuitry capable to perform the intra block copy operation.", "The video decoder 300 may use the spatial predictor 170 for block copy operations and at least parts of the memory 190, such as IBC buffer 320, for the intra block copy.", "The IBC buffer 320 may be part of the memory storage unit 190 which may be off-chip, or external to the circuitry.", "The decoder 300 may further include an internal, or on-chip storage unit represented by a local buffer 330.In other examples, memory storage 190 and local buffer 330 may be on-chip, off-chip and/or some combination of on-chip and off-chip such that the local buffer 330 provides temporary local storage that is accessible more quickly than the relatively long term storage in the memory storage 190.Although, FIG.", "3 does not illustrate a spatial predictor block 170, other example video decoders may include the spatial predictor block 170.The spatial predictor 170 may include suitable circuitry, which may be operable with logic and/or code, to perform the intra block copy.", "The blocks 210 of the frame that have been already decoded and filtered may be written into the memory storage unit 190.In addition, a copy of the blocks 210, prior to the operations by the loop filter 180, may be stored in the IBC buffer 320.Thus, two copies of the blocks 210 may exist—one pre-filtered stored the IBC buffer 320 and one post-filtered, stored in the reference picture frames 196.The pre-filtered content in the IBC buffer 320 may be used as data source for the intra block copy.", "Alternatively, or in addition, at least a part of the pre-filtered decoded blocks 210 may be stored in a faster storage location, such as a local storage location, which may be an internal or on-chip storage, such as a local buffer 330.In another exemplary scenario, the local storage location may be used to store part of the post-filtered decoded blocks 210.The local storage unit 330 may have lower memory latency than the memory storage unit 190.The local buffer 330 may have lesser capacity than the memory storage unit 190 and therefore, all of the pre-filtered decoded blocks 210 may not be stored in the local buffer 330.FIG.", "4 illustrates three example memory access cases.", "There may be other memory access scenarios possible, and these are just example cases for purpose of explanation.", "The decoded blocks 210 may be distributed across the slower and faster memory locations, such as the local buffer 330 and the IBC buffer 320 in the memory 190.The local buffer 330 may be on-chip storage and the IBC buffer 320 may be off-chip storage.", "Thus, the spatial predictor 170 may access the decoded blocks 210 from the memory storage unit 190 and/or the local buffer 330 to copy contents of the decoded blocks 210 to the block 220 that is currently being decoded.", "In case 1 shown in FIG.", "4, the source data to be copied into block 220 is part of decoded blocks 210 that are all stored in the local buffer 330.In case 2, the source data blocks 210 are all stored in the IBC buffer 320.Case 3 illustrates an example where part of the source data blocks 210 to be copied into block 220 are stored in the faster, local buffer 330 and the rest of the data blocks are in the relatively slower memory 190, particularly in the IBC buffer 320.In all cases, the intra block copy operation may be performed in response to the video content stream including an indicator to perform the intra block copy operation.", "The intra block copy performed may have to access slower memory, such as the memory storage unit 190, which may slow down the video decoding process, for example due to the memory latency.", "The memory access fetching time may stall the pipeline.", "Further yet, since the intra block copy operates on blocks of the same frame data, the data that is to be copied into block 220 may have been decoded recently, and may not have yet been written into the IBC buffer 320.Thus, the decoder pipeline may have to first wait for the write operation for the decoded blocks 210 to complete and then incur the memory latency to read the written decoded blocks 210.Although a cache may be partial solution, cache misses may still lead to memory latency, which in a real time operation such as video decoding are not affordable.", "FIG.", "5 illustrates an example video decoder 500 that provides a technical solution involving a combination of the local buffer 330 combined with the temporal prediction unit 160, an intra block control unit 510, and a prefetch buffer 520 to manage the memory requests.", "This solution presents an implementation of the intra block copy with minimal incremental area addition to the existing video decoder chip/circuitry architecture, and no loss of pipeline performance.", "The control unit 510 may include suitable circuitry and logic and/or code to perform the control and perform the intra block copy operations.", "The control unit 510 may identify the IBC operation to be performed based on the output of the symbol decoder 110.The symbol decoder 110 may decode the symbols of the input video content stream, which may contain a series of communication packets with encoded video data as payload.", "Alternatively, or in addition, the symbol decoder 110 may identify the intra block copy operation in response to symbols, such as instructions, or intra block copy information in the decoded video content.", "The symbols may be in the header or payload portion of the incoming video stream.", "The incoming video stream may include information indicating that the intra block copy is to be performed for one or more blocks.", "The information may further indicate the source blocks from which video data is to be copied.", "The information may further include identification of the destination blocks to which the data is to be copied.", "Alternatively, or in addition, if the data is to be copied from a sequence of blocks to another sequence, the information may indicate an identity of the starting blocks of each sequence and the number of blocks to be copied.", "Thus, the control unit 510 may parse the intra block copy ‘command’ in the bit stream of the incoming video content.", "Upon identification of the intra block copy operations to be performed, the control unit 510 may identify source data which can be prefetched so as to hide latency.", "That is, the control unit 510, upon interpreting the decoded intra block copy related symbols, may operate ahead of pixel processing components of the video decoder 500.The control unit 510 may schedule fetches of the source data into the prefetch buffer 520, which is a buffer for prefetched data.", "Accordingly, when the current block 220 is being processed by the other components of the video decoder, the data would be readily available in the prefetch buffer 520, instead of the IBC buffer 320.Since the prefetch buffer 520 provides memory access at lower memory latency than the IBC buffer 320, the video decoder pipeline may operate faster to provide decoded video content output at the desired real-time frame rate for continuous playback.", "The data stored in the prefetch buffer 520 may be associated with the intra block copy operation to be performed, so that when a component of the decoder 100 performs or initiates performance of the intra block copy, the component may fetch the data from the prefetch buffer 520, instead of the IBC buffer 320.The control unit 510 may control the prefetches so as to handle the possible distribution of the source decoded blocks 210 across the local buffer 330 and the IBC buffer 320.The control unit 510 may know the predetermined size of the local buffer 330.Further, the control unit 510 may know the present block being decoded, and thus which pixels will be in the local buffer 330 at the time the intra block copy is to be performed.", "Based on the predetermined size, and the current block being decoded, the control unit 510 may be able to calculate and thus predict, which pixels will be in the local buffer 330.The pixels that may not fit in the local buffer 330 may be stored in the IBC buffer 320 and may need a slower memory fetch request.", "The control unit 510 may further compute details to fetch the content from the IBC buffer 320, such as an address of the source data, based on the intra block copy request and current block being decoded.", "The prefetch buffer may be sized to accommodate the largest possible block copy size, thereby guaranteeing that block copy fetches will hit valid data.", "Thus, the fixed local buffer 330 size may be large enough to guarantee memory fetches will hit valid data.", "The control unit 510 may handle the example cases illustrated in FIG.", "4 as described further.", "As in case 1, if the source data may be stored in the local buffer 330, no pipeline-stalling memory request, such as a DRAM request, may be performed.", "In cases 2 and/or 3, when the source data is partially or wholly in the off-chip storage 320, the control unit 510 may perform a memory request to prefetch the source data stored in the IBC buffer 320 into the local buffer 330.The control unit 510 may either perform the prefetch or schedule the prefetches so that the source data is copied into the local buffer 330 at a later time, but before the data is requested for the block copy by the spatial predictor 170 of the video decoder 500.Thus, the source data to be copied into the block 220 may be available in the local buffer 330 at the time block 220 is being decoded.", "Additionally, or alternatively, the source data will be available in the local buffer 330 at the time the intra block copy function associated with the block 220 is being performed by the video decoder, for example in the spatial predictor 170.Further, the control unit 510 may communicate to the spatial predictor 170, the availability of the source data in the local buffer 330.For example, the control unit 510 may set a value of a flag that is accessible by the spatial predictor 170 such that the flag indicates the availability of the source data in the local buffer 330.For example, the flag may be set to value 1 in case the source data is available in the local buffer and 0 otherwise.", "Alternatively, or in addition, the control unit 510 may pass a message to the spatial predictor 170 indicating such availability.", "Other techniques to communicate the availability may also be used.", "The spatial predictor 170, in response to the communication, may access the source data from the local buffer 330 or the IBC buffer 320.Alternatively, or in addition, in an example video decoder, the spatial predictor 170 may first attempt to fetch the source data from the local buffer 330.In case the source data is not available via the local buffer 330, the spatial predictor 170 may proceed to access the source data from the IBC buffer 320.The control unit 510 may use the memory access functionality of the temporal predictor 160 and spatial predictor 170 to perform or schedule the prefetches from the memory 190.For example, in the exemplary video decoder of FIG.", "6, the temporal predictor 160 may be adapted to fetch data from the memory 190, as part of the temporal prediction operations that may involve older frames.", "The spatial predictor 170 may be adapted to fetch data from the memory 190 as part of the spatial prediction operations that may involve decoded blocks from the same frame, as described elsewhere in this document.", "Further yet, the control unit 510 may use the spatial predictor 170 to copy the data into the local buffer 330.The spatial decoder 170 may be adapted to store data in the local buffer 330 after completion of reconstruction operations.", "In one example video decoder, the local buffer 330 may be a part of the spatial predictor 170.Thus, the control unit 510 may send prefetch instructions to the temporal predictor 160 to prefetch the source data from decoded blocks 210 stored in the memory 190, and further send copy, or write instructions to the spatial predictor 170 to store the prefetched data in the local buffer 330.The prefetched data may be stored in the local buffer 330 at a location allocated to the current block 220.The temporal predictor 160 may not otherwise be active during intra block copy operations and hence is available to perform the prefetches.", "Thus, video decoder 600 may hide the memory latency of the prefetches performed by the temporal predictor 160 in response to the intra block copy requests, and eliminate memory-latency performance bottleneck.", "At least some of the steps performed during a method to decode video content related bit stream with intra block copy operations are illustrated in the example flowchart of FIG.", "8.The steps illustrated in FIG.", "8 may hide memory latency performance bottlenecks by using prefetches of the source data to be used for the intra block copy operations, thus allowing a continuous real time video playback.", "The method may be performed by example video decoders such as those described throughout this disclosure.", "The method may involve parsing an incoming bitstream (802).", "The bitstream may be an encoded bitstream containing video content.", "For example, the bitstream may be encoded using a HEVC standard, or any other video encoding standard.", "The incoming bitstream may be transmitted by another device and/or may be read from the memory storage unit 190.The control unit 510 may parse the bitstream to identify the intra block command in the bitstream (806).", "The parsing may be performed after the bitstream is decoded by the symbol decoder 110.The intra block copy command may involve a block that the decoder may handle at a later time, after completion of the current block that the video decoder is working on.", "The control unit 510 may identify the source data from the decoded blocks 210 that may be copied into the block that will be processed at a later time (810).", "The control unit 510 may identify the earlier decoded blocks 210 from which the source data may be copied.", "The control unit 510 may determine whether the source data is stored in the local buffer 330 or in memory 190 (816, 820).", "The control unit 510 may make this determination based on a predetermined size of the local buffer 330, the current block being processed by the decoder, and how many blocks in the video stream have been processed since the blocks containing the source data.", "In addition, or alternatively, a predetermined number of decoded blocks may be stored in the local buffer 330.The local buffer 330 may store a predetermined number of previously decoded blocks.", "The spatial predictor 170 may overwrite the local buffer 330 with the most recently decoded blocks.", "For example, assume the predetermined number of blocks stored in the local buffer 330 is three.", "In this exemplary case, blocks k, k+1,and k+2 may be stored in the local buffer 330 after the blocks k, k+1, and k+2 are decoded, but prior to filtering of those blocks.", "However, a block k+3, after decoding would be stored in the local buffer 330 overwriting block k. It will be understood that the predetermined number of blocks may have a different value than 3, as used in this example.", "Therefore, based on the predetermined number of blocks in the local buffer 330, the control unit 510 may determine whether the source data blocks 210 are stored in the local buffer 330 or the memory 190, or a combination of the two.", "In case the source data blocks are stored in the local buffer 330, the control unit 510 may not have to perform any further steps to fetch the data blocks, rather copy contents from location of the source data blocks on the local buffer 330 to the location allocated to the current block 220 in the local buffer 330 (824).", "In case the source data is partially or wholly stored in the memory 190, the control unit 510 may request prefetching the source data form the memory 190 and storing the prefetched data into prefetch buffer 520, if required, and use the on-chip prefetched data.", "(826, 828).", "The data stored in the memory 190 may be directly stored in the location allocated to the current block 220 in the prefetch buffer 520.The control unit 510 may request the temporal predictor 160 to perform the operations for prefetching the source data from the memory 190.The control unit 510 may request the spatial predictor 170 to perform the operations to store the prefetched source data into the local buffer 330.The control unit 510 may schedule the prefetch and copy operations so that the video decoder has the pixel data to be copied into the block associated with the intra block copy, when the block is processed by the video processor (830).", "Further, the control unit 510 may communicate to the decoder, for example to the spatial predictor 170, that the source data is available in the local buffer 330.In addition, the control unit 510 may prefetch the data from the IBC buffer 320, in the memory 190, to the location in the local buffer 330 allocated to the block for which the intra block copy is to be performed.", "Accessing the content from the local buffer 330 or the prefetch buffer may have negligible memory latency as compared to the IBC buffer 320 in the memory 190.In case, the content is not copied into the local buffer in this prefetch manner, a memory access will result at a later time, which may stall the decoder pipeline.", "FIG.", "7 illustrates exemplary steps performed when processing an example frame.", "FIG.", "7 represents the circuitry of example video decoder except the symbol decode 110, control unit 510, and loop filter 180 as one block titled pixel processing.", "Further, when processing blocks 1 through n of the frame, the processing is initiated at 710ab, decoded at 720ab by the pixel processing circuitry, and further stored in the local buffer 330 and memory 190 at 730ab before forwarding for the loop filter operation at 740ab.", "Block n+1 may involve an intra block copy instruction.", "Accordingly, at 750, the intra block copy instruction may be parsed and the control unit 510 notified of the instruction.", "The control unit 510 may identify the location of the source blocks.", "In case the source block involves a recently decoded block that may be stored in the local buffer 330, such as n−1, the contents of such a recent source block may be copied from the local buffer 330 itself at 770.In case, the source block involves a decoded block such that it is no longer in the local buffer 330, for example block 1, a prefetch operation may be initiated to copy the contents of that block from the memory 190 at 780.Once all contents of the block n+1 have been copied, from decoded source blocks, the block n+1 may be forwarded for the loop filtering, as indicated by 790.While FIG.", "7 illustrates an exemplary sequence, it should be noted that the order of the events may be modified according to the decoder pipeline timing requirements.", "For example, the IBC control unit 510 may identify an intra block copy in block n substantially simultaneously while a prefetch operation is in progress for block n−1.Further, a block copy operation may be in progress for block n−2 at substantially the same time.", "The methods, devices, processing, and logic described above may be implemented in many different ways and in many different combinations of hardware and software.", "For example, all or parts of the implementations may be circuitry that includes an instruction processor, such as a Central Processing Unit (CPU), microcontroller, or a microprocessor; an Application Specific Integrated Circuit (ASIC), Programmable Logic Device (PLD), or Field Programmable Gate Array (FPGA); or circuitry that includes discrete logic or other circuit components, including analog circuit components, digital circuit components or both; or any combination thereof.", "The circuitry may include discrete interconnected hardware components and/or may be combined on a single integrated circuit die, distributed among multiple integrated circuit dies, or implemented in a Multiple Chip Module (MCM) of multiple integrated circuit dies in a common package, as examples.", "The circuitry may further include or access instructions for execution by the circuitry.", "The instructions may be stored in a tangible storage medium that is other than a transitory signal, such as a flash memory, a Random Access Memory (RAM), a Read Only Memory (ROM), an Erasable Programmable Read Only Memory (EPROM); or on a magnetic or optical disc, such as a Compact Disc Read Only Memory (CDROM), Hard Disk Drive (HDD), or other magnetic or optical disk; or in or on another machine-readable medium.", "A product, such as a computer program product, may include a storage medium and instructions stored in or on the medium, and the instructions when executed by the circuitry in a device may cause the device to implement any of the processing described above or illustrated in the drawings.", "The implementations may be distributed as circuitry among multiple system components, such as among multiple processors and memories, optionally including multiple distributed processing systems.", "Parameters, databases, and other data structures may be separately stored and managed, may be incorporated into a single memory or database, may be logically and physically organized in many different ways, and may be implemented in many different ways, including as data structures such as linked lists, hash tables, arrays, records, objects, or implicit storage mechanisms.", "Programs may be parts (e.g., subroutines) of a single program, separate programs, distributed across several memories and processors, or implemented in many different ways, such as in a library, such as a shared library (e.g., a Dynamic Link Library (DLL)).", "The DLL, for example, may store instructions that perform any of the processing described above or illustrated in the drawings, when executed by the circuitry.", "Various implementations have been specifically described.", "However, many other implementations are also possible." ] ]
Patent_15876015
[ [ "HYPERVISOR ENFORCEMENT OF CRYPTOGRAPHIC POLICY", "Techniques for restricting the execution of algorithms contained in applications executing on virtual machines executing within a computer system are described herein.", "A first sampled set of computer executable instructions is gathered from a virtual machine by a controlling domain and compared against a reference set of computer executable instructions.", "If the first set is similar to the reference set, and if the execution of the algorithm corresponding to the reference set is restricted by one or more computer system polices, one or more operations limiting the execution of the restricted algorithm are performed, thus ensuring conformance with the computer system policies." ], [ "1.A computer-implemented method, comprising: identifying, based at least in part on computer executable instructions executing on a computer system, a plurality of execution traces, each of the plurality of execution traces including information corresponding to an algorithm that is restricted by one or more system policies; determining whether the plurality of identified execution traces satisfies a set of conditions; and causing the computer system to perform one or more actions based at least in part on the determination.", "2.The computer-implemented method of claim 1, wherein the set of conditions further comprise determining whether a number of the plurality of identified execution traces exceeds a threshold value.", "3.The computer-implemented method of claim 2, further comprising computing a statistical measure for each of the plurality of identified execution traces based at least in part on determining that the number of the plurality of identified execution traces exceeds the threshold value.", "4.The computer-implemented method of claim 3, further comprising: determining that the statistical measure satisfies a second set of conditions; and causing the computer system to perform the one or more actions based at least in part on the determination.", "5.A system, comprising: memory to store instructions that, if executed by one or more processors of the system, cause the system to: identify, based at least in part on computer executable instructions executing on a computer system, a plurality of execution traces, each of the plurality of execution traces including information corresponding to an algorithm that is restricted by one or more system policies; and as a result of the plurality of identified execution traces satisfying a set of conditions, cause the computer system to perform one or more actions based at least in part on the determination.", "6.The system of claim 5, wherein the set of conditions comprises instructions that, if executed by the one or more processors of the system, further cause the system to determine whether a number of the plurality of identified execution traces exceeds a threshold value.", "7.The system of claim 6, wherein the instructions that, if executed by the one or more processors of the system, further cause the system to compute a statistical measure for each of the plurality of identified execution traces based at least in part on the determination that the number of the plurality of identified execution traces exceeds the threshold value.", "8.The system of claim 7, wherein the statistical measure is at least one of: an average; an arithmetic mean; a median; a time-weighted average; or a histogram.", "9.The system of claim 7, wherein the instructions that, if executed by the one or more processors of the system, further cause the system to: determine whether the statistical measure satisfies a second set of conditions; and cause the computer system to perform the one or more actions based at least in part on the determination.", "10.The system of claim 9, wherein perform the one or more actions further comprises instructions that, if executed by the one or more processors of the system, further cause the system to restrict the computer executable instructions based at least in part on the determination that the statistical measure satisfies the second set of conditions.", "11.The system of claim 9, wherein perform the one or more actions further comprise instructions that, if executed by the one or more processors of the system, further cause the system to identify additional execution traces that include information corresponding to the algorithm that is restricted by the one or more system policies based at least in part on the determination that the statistical measure does not satisfy the second set of conditions.", "12.The system of claim 5, wherein each of the plurality of execution traces including information corresponding to an algorithm that is restricted by one or more system policies are identified by sampling an application executing computer executable instructions on the computer system.", "13.A non-transitory computer-readable storage medium having stored thereon executable instructions that, if executed by one or more processors of a computer system, cause the computer system to at least: determine, based at least in part on computer executable instructions executing on a computer system, whether a plurality of execution traces satisfies a set of conditions, wherein the plurality of execution traces are obtained by identifying execution traces that include information corresponding to an algorithm restricted by one or more system policies; and cause the computer system to perform one or more actions based at least in part on the determination.", "14.The non-transitory computer-readable storage medium of claim 13, wherein the set of conditions comprises instructions that, if executed by the one or more processors of the system, further cause the system to determine whether a number of the plurality of execution traces exceeds a threshold value.", "15.The non-transitory computer-readable storage medium of claim 14, wherein the instructions that, if executed by the one or more processors of the system, further cause the system to compute a statistical measure for each of the plurality of execution traces based at least in part on the determination that the number of the plurality of execution traces exceeds the threshold value.", "16.The non-transitory computer-readable storage medium of claim 15, wherein the statistical measure is at least one of: an average; an arithmetic mean; a median; a time-weighted average; or a histogram.", "17.The non-transitory computer-readable storage medium of claim 15, wherein the instructions that, if executed by the one or more processors of the system, further cause the system to: determine whether the statistical measure satisfies a second set of conditions; and cause the computer system to perform the one or more actions based at least in part on the determination.", "18.The non-transitory computer-readable storage medium of claim 17, wherein perform the one or more actions further comprises instructions that, if executed by the one or more processors of the system, further cause the system to restrict the computer executable instructions based at least in part on the determination that the statistical measure satisfies the second set of conditions.", "19.The non-transitory computer-readable storage medium of claim 17, wherein perform the one or more instructions further comprise instructions that, if executed by the one or more processors of the system, further cause the system to identify additional execution traces that include information corresponding to the algorithm that is restricted by the one or more system policies based at least in part on the determination that the statistical measure does not satisfy the second set of conditions.", "20.The non-transitory computer-readable storage medium of claim 13, wherein each of the plurality of execution traces including information corresponding to an algorithm that is restricted by one or more system policies are identified by sampling an application executing computer executable instructions on the computer system." ], [ "<SOH> BACKGROUND <EOH>Modern computing systems place high importance on system security, and also place high importance on conformance with system policies.", "In many computer systems, particularly distributed computer systems, and especially those involving virtualized computing environments where a plurality of guest virtual machines may be hosted on shared physical host machines, both system security and policy conformance may become a concern.", "The distributed systems in which the guest virtual machines are implemented are often highly complex, comprising large numbers of networked host machines and a correspondingly large number of guest virtual machines.", "Such computer systems often operate with a large variety of operating systems and applications, and these operating systems and applications are often required to conform to a variety of system security policies.", "Frequently, implementations of cryptographic algorithms do not integrate well with policy systems, particularly without direct hardware or operating system integration.", "Such hardware or operating system integration is not easily achievable on distributed systems with a plurality of guest virtual computing systems because of lack of access to system hardware and/or operating system resources.", "Additionally, identifying and remediating restricted cryptographic algorithms implemented on distributed computing systems with the accompanying varied computing system environments is often problematic due to the nature of the computer system environments, making enforcement of consistent cryptographic policies on such systems difficult." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>Various embodiments in accordance with the present disclosure will be described with reference to the drawings, in which: FIG.", "1 illustrates an example environment where applications may be analyzed for cryptographic policy violations in accordance with at least one embodiment; FIG.", "2 illustrates an example environment where applications may be verified for conformance with cryptographic policies in accordance with at least one embodiment; FIG.", "3 illustrates an example environment where computer executable instructions may be collected and analyzed in accordance with at least one embodiment; FIG.", "4 illustrates an example process for collecting and analyzing computer executable instructions to determine the presence of cryptographic algorithms in accordance with at least one embodiment; FIG.", "5 illustrates an example environment where a trace of a group of computer executable instructions may be represented by a graph in accordance with at least one embodiment; FIG.", "6 illustrates an example environment where a trace of a group of computer executable instructions may be weighted by a multiple-edge and a weighted graph in accordance with at least one embodiment; FIG.", "7 illustrates an example environment where a trace graph may be analyzed in accordance with at least one embodiment; FIG.", "8 illustrates an example environment where a trace graph with patterns may be analyzed in accordance with at least one embodiment; FIG.", "9 illustrates an example process for computing the likelihood that a group of computer executable instructions comprise at least a portion of a cryptographic algorithm in accordance with at least one embodiment; and FIG.", "10 illustrates an environment in which various embodiments can be implemented.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "14/852,361, filed Sep. 11, 2015, entitled “HYPERVISOR ENFORCEMENT OF CRYPTOGRAPHIC POLICY,” which is a continuation of U.S. patent application Ser.", "No.", "14/223,868, filed on Mar.", "24, 2014, now U.S. Pat.", "No.", "9,135,437, entitled “HYPERVISOR ENFORCEMENT OF CRYPTOGRAPHIC POLICY,” the disclosures of which are incorporated by reference herein in their entirety.", "BACKGROUND Modern computing systems place high importance on system security, and also place high importance on conformance with system policies.", "In many computer systems, particularly distributed computer systems, and especially those involving virtualized computing environments where a plurality of guest virtual machines may be hosted on shared physical host machines, both system security and policy conformance may become a concern.", "The distributed systems in which the guest virtual machines are implemented are often highly complex, comprising large numbers of networked host machines and a correspondingly large number of guest virtual machines.", "Such computer systems often operate with a large variety of operating systems and applications, and these operating systems and applications are often required to conform to a variety of system security policies.", "Frequently, implementations of cryptographic algorithms do not integrate well with policy systems, particularly without direct hardware or operating system integration.", "Such hardware or operating system integration is not easily achievable on distributed systems with a plurality of guest virtual computing systems because of lack of access to system hardware and/or operating system resources.", "Additionally, identifying and remediating restricted cryptographic algorithms implemented on distributed computing systems with the accompanying varied computing system environments is often problematic due to the nature of the computer system environments, making enforcement of consistent cryptographic policies on such systems difficult.", "BRIEF DESCRIPTION OF THE DRAWINGS Various embodiments in accordance with the present disclosure will be described with reference to the drawings, in which: FIG.", "1 illustrates an example environment where applications may be analyzed for cryptographic policy violations in accordance with at least one embodiment; FIG.", "2 illustrates an example environment where applications may be verified for conformance with cryptographic policies in accordance with at least one embodiment; FIG.", "3 illustrates an example environment where computer executable instructions may be collected and analyzed in accordance with at least one embodiment; FIG.", "4 illustrates an example process for collecting and analyzing computer executable instructions to determine the presence of cryptographic algorithms in accordance with at least one embodiment; FIG.", "5 illustrates an example environment where a trace of a group of computer executable instructions may be represented by a graph in accordance with at least one embodiment; FIG.", "6 illustrates an example environment where a trace of a group of computer executable instructions may be weighted by a multiple-edge and a weighted graph in accordance with at least one embodiment; FIG.", "7 illustrates an example environment where a trace graph may be analyzed in accordance with at least one embodiment; FIG.", "8 illustrates an example environment where a trace graph with patterns may be analyzed in accordance with at least one embodiment; FIG.", "9 illustrates an example process for computing the likelihood that a group of computer executable instructions comprise at least a portion of a cryptographic algorithm in accordance with at least one embodiment; and FIG.", "10 illustrates an environment in which various embodiments can be implemented.", "DETAILED DESCRIPTION In the following description, various embodiments will be described.", "For purposes of explanation, specific configurations and details are set forth in order to provide a thorough understanding of the embodiments.", "However, it will also be apparent to one skilled in the art that the embodiments may be practiced without the specific details.", "Furthermore, well-known features may be omitted or simplified in order not to obscure the embodiment being described.", "Techniques described and suggested herein include systems and methods for enforcing cryptographic policies in applications running on distributed systems under the control of a controlling domain such as a hypervisor.", "An application running on a virtual machine (VM) instance may be subject to a variety of system policies such as policies regarding access to cryptographic resources, access by users to such resources, allowed and/or disallowed cryptographic algorithms, minimal cryptographic security requirements and/or other such policies.", "An extensive and varied number of standards exist for computer-implemented cryptographic methods and an organization and/or system may wish to enforce policies associated with several of these standards.", "Some implementations of cryptographic algorithms may be integrated with systems to enforce policy.", "For example, many applications integrate well with the Federal Information Processing Standard (FIPS) Publication 140-2 (FIPS PUB 140-2, also referred to herein simply as “FIPS”) security standard and a system compliant with the standard may be referred to as “FIPS compliant.” Deploying a system that is FIPS compliant generally involves deploying a FIPS compliant version of an operating system and then selecting only FIPS compliant applications on that system.", "Such a deployment, while conforming to the standard of FIPS PUB 140-2, is limited in that it may require alteration of the operating system, may require integration with system hardware, may restrict the use of many applications (including custom applications) and may not fully support a full subset of policy capabilities that may be contemplated by an organization.", "Some other implementations of cryptographic algorithms may not integrate well with systems to enforce policy, lacking support within operating systems or support for integration with policy systems.", "Additionally, both systems that integrate well and those that do not integrate well generally do not perform well at identifying unapproved and/or insufficiently secure use of cryptography algorithms that may be introduced into a system by users, services, procedures and/or other such computer system entities, making identifying and/or remediating unauthorized use of cryptography difficult.", "Techniques described and suggested herein include techniques for enforcing cryptographic policies in applications running on distributed systems with a plurality of virtual machines operating under the control of a controlling domain such as a hypervisor.", "As used herein, unless otherwise stated or made clear from context, the term “hypervisor” may be understood to refer to the hypervisor and/or to one or more processes, applications, services and/or combinations thereof, running under the control of and/or in conjunction with the hypervisor.", "The hypervisor may first collect traces of computer executable instructions executed inside of a virtual machine running under the control of the hypervisor.", "A hypervisor may examine the computer executable instructions executed inside of a virtual machine running under its control by recording at least a subset of the computer executable instructions that are forwarded to the host computer hardware for execution as they are executed.", "In some embodiments, the hypervisor may organize the examining and recording of the computer executable instructions according to the CPU, the virtual CPU, the virtual machine, the application, the application thread, the application hyperthread and/or by other such groupings.", "In some embodiments, the hypervisor may collect and/or record samples of computer executable instructions (also referred to herein simply as “sampling”) by intermittently examining the contents of memory locations within the virtual machine to determine information such as which instruction is currently executing, the location of the instruction within memory, data being used by the instruction, parameters being used by the instruction, the time of execution and/or other such information.", "Sampling may be performed by the hypervisor, or by a process such as a trace collector running within, or under the control of, the hypervisor.", "In some embodiments, sampling may be started and stopped according to one or more system conditions.", "For example, sampling may be a resource intensive operation and, consequently, may be turned off when system resources are unavailable.", "Sampling may also be “turned down” (executed less frequently) when, for example, system resources are scarce, when well-known and/or verified applications are running, according to system policies or according to other such system conditions.", "Sampling may similarly be turned on or “turned up” (executed more frequently) as a result of one or more system polices or conditions.", "For example, a system configured for high-security use may always keep sampling turned on and fully turned up in order to ensure system security compliance while a system configured for lower-security use may sample less frequently.", "Sampling frequency may also be adjusted in response to one or more events that occur in a system.", "In some embodiments, sampling may be turned on and/or turned up when a new user accesses the system, or when a new and/or unrecognized application starts, or when suspicious activity is detected by one or more processes and/or services running on the computer system or when other such similar events occur.", "Sampling may also be turned off and/or turned down after such new processes, users, or applications have be examined and found to be acceptable.", "In some embodiments, sampling may always be turned off for certain users, modules and applications including, but not limited to, the guest operating system, administrative users, verified modules running under the control of the hypervisor and/or the guest operating system and other such trusted entities.", "In some embodiments, one or more of the policies relating to whether sampling occurs and the frequency at which sampling occurs may exist as part of cryptographic policies, as part of system policies, as part of hypervisor policies or in a combination of these and/or other such polices.", "As may be contemplated, the factors for adjusting sampling and/or sampling rates described herein are illustrative examples, and other such factors for adjusting sampling and/or sampling rates may be considered as within the scope of the present disclosure.", "After a plurality of samples has been gathered by the hypervisor, sample analysis may begin.", "In some embodiments, the hypervisor may continue to gather samples while performing the analysis of the previous set of samples.", "The hypervisor may also suspend and/or turn down the sampling during analysis in, for example, scarce resource situations and, may also turn up the sampling during analysis if, for example, system security demands are high.", "The hypervisor may begin analysis by first creating a graph representation of the sampled computer executable instructions (the graph may also be referred to herein as a “walk-through” or as a “walk-through graph”), grouping the sampled computer executable instructions (also referred to herein as the “instructions”) temporally, where the term graph is used in the mathematical sense, comprising a collection of vertices and edges connecting the vertices.", "So, for example, if at time “A”, an application executes instruction “X”, at time “B”, an application executes instruction “Y” and at time “C”, an application executes instruction “Z”, and if times “A”, “B”, and “C” are close together, then the hypervisor may create a walk-through graph with vertices representing the instructions “X”, “Y” and “Z”, with edges representing the temporal connection between “X” and “Y” and between “Y” and “Z.” Structures of interest within the walk-through may include sets of instructions that are executed in a consistent pattern, with a consistent starting and stopping point, wherein the instructions executed are both temporally located (all occurring within a short period of time) and spatially located (all located near one another and generally executed in a consistent order).", "The hypervisor may look for certain structures that are executed multiple times, with consistent entry and exit points.", "In the above example, if instructions “X”, “Y” and “Z” may be frequently executed and in that same order, with consistent entry and exit points, the hypervisor may flag and/or otherwise denote that repeated executed instruction set.", "The hypervisor may also flag and/or otherwise denote looping structures within the walk-through.", "If, for example, in the above mentioned instruction set, the application, after executing instruction “Z”, repeatedly returned to execute instruction “X”, followed by instruction “Y”, followed by instruction “Z” again, this is a looping structure.", "After repeating the loop a number of times, the application may exit the loop and execute a different instruction (call it “W”).", "A hypervisor may flag and/or otherwise denote the repeated execution of “X-Y-Z” followed by a single execution of “W” as a recognizable execution pattern in the walk-through graph.", "Loops may be identified by the hypervisor by identifying back edges in the walk through.", "A back edge is an edge of a graph which, in a depth-first traversal of the graph, points to a first vertex of a set of vertices that has already been traversed.", "A back edge is an indicator of a loop in a graph.", "Back edges may be indicated by an instruction order that is different than an expected instruction order.", "In the above example, with the “X”−“Y”−“Z” instruction set, the expected order of execution of the instructions is “X”, followed by “Y”, followed by “Z” (instructions “X”, “Y” and “Z” are in that order, in the computer system memory of the virtual machine).", "When instruction “X” follows instruction “Z” in the loop, that edge of the walk-through graph may be contrary to the expected order and may indicate the possibility of a back-edge in the walk-through graph.", "Loops in the graph may correspond to loops in the executed code and may also be indicators of certain algorithms.", "Strong loops, where the same set of instructions may be executed in order, and a large number of times, may be indicated by graphs with multiple edges and/or by applying weights to temporal connection edges (edges between vertices that occur sequentially).", "For example, if the set of instructions “X”−“Y”−“Z” is executed one-hundred times in a row in a loop, there may be one-hundred edges between each of the instruction vertices.", "In some embodiments, the weight of repeated walk-through edges may be computed as a function of the number of repetitions of the associated pair of instructions such as, for example, a quadratic function, an exponential function, an inverse quadratic function, a logarithmic function and/or other such functional relationships.", "After identifying loops, the hypervisor may next group computer executable instructions together into one or more functional groups based at least in part on the identified loop structures.", "In each of the groups, each of the sets of executable instructions may comprise instructions that share temporal and/or spatial locality.", "In the example described herein, the instructions “X”, “Y” and “Z” may form a functional group based at least in part on their temporal and spatial locality as well as based, at least in part, on the identified loop structure.", "In some embodiments, instruction “W” may be included in the same functional group based at least in part on spatial locality and/or on temporal locality as being a common exit point of the “X”-“Y”−“Z” loop.", "The hypervisor and/or the trace analyzer may determine whether to include instruction “W” in the functional group based on policy, user preferences, administrator preferences, resource availability, computational complexity and/or other such disparate factors.", "In some embodiments, the hypervisor may select a subset of the groups for further analysis based at least in part on a variety of factors for the selection.", "The factors for selection of groups for further analysis include, but may not be limited to, a plurality of instructions sharing common data based on examining data transfer through one or more registers and/or memory locations specified in the computer executable instructions, a plurality of instructions sharing common parameters based on examining data transfer through one or more other registers and/or memory locations specified in the computer executable instructions, meta-sequences of instructions where group “A” of instructions temporally and/or spatially follows group “B” of instructions, one or more threshold values on intervening instructions that may be executed between the instructions in the group of instructions and/or between the meta-sequences of instructions and/or other such factors for selection for further analysis.", "As may be contemplated, the factors for selection of groups for further analysis described herein are merely illustrative examples, and other such factors for selection may be considered as within the scope of the present disclosure.", "Next, the hypervisor may determine whether the instructions in the groups selected for further analysis may comprise at least a portion of the implementation of one or more cryptographic algorithms.", "The hypervisor may determine whether the instructions comprise at least a portion of one or more cryptographic algorithms by comparing the detected loop structures and the computer executable instructions in the groups selected for further analysis against one or more reference implementations of cryptographic algorithms that may be stored in a repository of reference implementations of cryptographic algorithms (also referred to herein as a cryptographic database).", "For example, if it is known that a cryptographic algorithm uses one or more different loop structures, a cryptographic database may store one or more reference implementations of those one or more different loop structures.", "For example, if the looped instruction set “X”-“Y”-“Z” mentioned above was selected for further analysis, the hypervisor may compare the looped instruction set against a repository of reference implementations of known cryptographic algorithms.", "The repository may contain reference implementations that say, for example, that the instructions “X”, “Y” and “Z”, executed in a loop and in that order, comprise at least a portion of a known implementation of a cryptographic algorithm.", "The repository may contain reference implementations for “X”-“Z”-“Y”, or “X”-“Y”-“Q”-“Z” and/or other such ordered groupings of instructions and may also store indications as to whether such implementations do, do not and/or might indicate implementations of cryptographic algorithms.", "It should be noted that the examples of the “X”−“Y”−“Z” and other such computer executed instruction patterns mentioned herein are merely illustrative examples and are not meant to convey the scope or size of a group of related instructions.", "The number of instructions in a group of instructions may vary by implementation, by system, by type and scope of analysis and/or by other such factors.", "The hypervisor may determine whether the instructions in the groups of instructions selected for further analysis may comprise at least a portion of an implementation of one or more cryptographic algorithms by, for example, lists of instructions against reference lists of instructions, comparing sequences of instructions against reference sequences of instructions, comparing loops of instructions against reference loops of instructions, comparing sequences of loops and/or sequences of instructions against reference sequences of loops and/or sequences of instructions and/or other such comparisons.", "The reference implementation may include a number of markers (also referred to herein as “patterns” or “fingerprints”) for the hypervisor to compare groups of instructions against.", "For example, a reference implementation may indicate that any algorithm that executes instructions “X”, “Y” and “Z”, in that order, more than a threshold number of times, is probably a cryptographic algorithm.", "Another reference implementation may look at patterns in using a certain type of data in the algorithm.", "For example, a set of instructions which use a certain lookup table with known values to transform values may be an indicator of a cryptographic algorithm.", "The hypervisor may use the patterns or fingerprints to determine the likelihood that a group of related instructions may comprise at least a portion of an implementation of a cryptographic algorithm.", "A group of instructions that strongly matches a reference implementation in the instructions used, the sequence of instructions, the lack of unfamiliar and/or out-of-sequence instructions, the looping structure, the sequence of loops and/or sequences, the data used and/or other such markers may indicate a strong likelihood that the group of instructions may comprise at least a portion of an implementation of a cryptographic algorithm.", "By contrast, a group of instructions that, for example, only partially matches the above factors or that has a large number of unfamiliar and/or out of sequence instructions may indicate a less-strong likelihood that the group of instructions may comprise at least a portion of an implementation of a cryptographic algorithm.", "In some embodiments, the hypervisor may assign one or more scores indicating a confidence level that the group of instructions may comprise at least a portion of an implementation of one or more reference cryptographic algorithms.", "A group of instructions may, for example, be a 25% match for one reference cryptographic algorithm, a 5% match for another, a 90% match for a third and a 99% match for a fourth.", "In some embodiments, the hypervisor may use a variety of analysis tools to determine the likelihood that a group of instructions is at least similar to a reference implementation.", "For example, a graph of the group of instructions may be compared against a graph of the instructions in the reference implementation.", "Sequences of instructions may also be compared against sequences of instructions in the reference implementation.", "Where there are differences, the likelihood of a match may be computed by using similarity quantification techniques such as a distance metric, an edit distance (comparing the number of steps required to make two dissimilar objects the same), measurement of alignment (measuring deviation from a standard) and/or other such quantification techniques.", "As mentioned herein, there are several factors that the hypervisor may use to determine the likelihood that a group of instructions is similar to a reference implementation.", "For example, back edges may identify loop structures which, in turn, may be compared against reference loop structures.", "A loop structure that does not exactly conform to a reference loop structure, but that may be altered to exactly conform to a reference loop structure with a small number of changes (and a small distance metric or edit distance) may indicate a strong likelihood that the given loop structure may comprise at least a portion of an implementation of the cryptographic algorithm corresponding to the reference implementation.", "Similarly, close conformity of common entry and exit points from an algorithm, strongly correlated physical locality, strongly correlated temporal locality, presence and/or absence of intervening instructions and/or other such factors may be used by the hypervisor to assign one or more scores for the likelihood that a group of instructions may comprise at least a portion of an implementation of a cryptographic algorithm.", "In some embodiments, the hypervisor may select one or more data parameters from gathered sample data and compare the one or more data parameters to a data model associated with a reference implementation.", "The presence or absence of data that is similar to data in a reference implementation may be used to increase or decrease the likelihood that a group of instructions and a group of associated data parameters comprise at least a portion of an implementation of a cryptographic algorithm.", "For example, a reference implementation of a cryptographic algorithm may require the presence of a lookup table to transform data values.", "A group of instructions that is similar to the reference implementation, but that does not include any such lookup table, may have a decreased likelihood of comprising an implementation of the reference cryptographic algorithm.", "Similarly, a group of instructions that is not very similar to the reference implementation, but that has a lookup table that is very similar to the reference lookup table, may have an increased likelihood of comprising an implementation of the reference cryptographic algorithm.", "In some embodiments selecting and/or comparing data parameters may be omitted if the reference implementation has no reference parameters or if the reference implementation indicates a match for all choices of data parameters.", "Using the one or more likelihood scores based on the reference implementation and/or the comparison with the reference implementation data parameters, the hypervisor may next determine whether the likelihood that a group of instructions may comprise at least a portion of an implementation of a reference cryptographic algorithm is sufficient to consider whether that implementation may be prohibited by one or more cryptographic policies.", "In one embodiment, the hypervisor may evaluate the likelihood that a group of instructions may comprise at least a portion of an implementation of a reference cryptographic algorithm by first looking at the percentage of the samples whose likelihood score exceeds a certain threshold value.", "The threshold value may be used to prevent skewing of the average by samples that were taken when the virtual machine was performing some other action.", "Such samples are not likely to conform to any particular implementation of a reference cryptographic algorithm and thus, would skew the average with a 0% likelihood score.", "As an illustrative example, consider ten samples of an application that comprise at least a portion of an implementation of a reference cryptographic algorithm.", "Five of the samples may show that there is a 95% likelihood that the samples may comprise at least a portion of a reference cryptographic algorithm and five of the samples may show that there is a 5% likelihood that the samples may comprise at least a portion of a reference cryptographic algorithm.", "The 5% samples may be because at the time that the samples were taken, the virtual machine may have been performing a different function.", "The average may indicate that there is a 50% likelihood that the samples comprise at least a portion of the implementation of a reference cryptographic algorithm, but a much stronger indicator may be that 50% of the samples indicate that there is a 95% likelihood that the samples comprise at least a portion of the implementation of a reference cryptographic algorithm.", "If it is determined that a group of instructions being executed by an application is likely to comprise at least a portion of an implementation of a reference cryptographic algorithm, the hypervisor may determine whether the cryptographic algorithm implementation is prohibited by a cryptographic policy based on the reference implementation and/or the data parameters.", "In the event that an implementation is prohibited by system policy, the likelihood score described above herein may be used to determine whether an application should be prevented from continuing to execute the cryptographic algorithm.", "One or more likelihood score conditions may be evaluated.", "A likelihood score condition is a condition based at least in part on computed likelihood scores and also based at least in part on one or more system policies.", "For example, a computer system may have a likelihood score condition indicating that if a percentage of the likelihood scores exceed a threshold value, one or more policy operations should be performed.", "In another example, a computer system may have a likelihood score condition indicating that if the maximum likelihood score is within one range of values, a first set of one or more policy operations should be performed and if the maximum likelihood score is within a different range of values, a second set of one or more policy operations should be performed.", "As may be contemplated, the examples of likelihood score conditions described herein are merely illustrative examples and other such likelihood score conditions may be considered as within the scope of the present disclosure.", "In some embodiments, where the likelihood is low, the hypervisor may elect to continue sampling the application to see if the likelihood increases or decreases.", "An application may be put on a watch list where it is allowed to continue to execute, but sampling and analysis may continue.", "Policy determinations for how to react to various algorithms may vary.", "For example, some algorithms may always be disallowed if there is even a slight likelihood that the algorithm in question comprises at least a portion of the implementation of a reference cryptographic algorithm.", "Some algorithms may only be disallowed if the likelihood exceeds a certain threshold value.", "Some algorithms may be allowed for some data parameters and disallowed for other data parameters.", "For example, a system may have a cryptographic policy that a certain type of encryption may be used, but only if, for example, a cryptographic key associated with the cryptographic algorithm exceeds a certain minimum complexity.", "An application that uses a key that exceeds that minimum complexity may be allowed, while an application that uses a key that does not exceed that minimum complexity may not be allowed.", "In some embodiments, if the hypervisor determines that an application is executing a disallowed cryptographic algorithm, the hypervisor may perform one or more operations to address the execution of the disallowed algorithm.", "The hypervisor may, for example, block execution of a portion of computer executable instructions by the virtual machine based at least in part on the determination that the implementation of the cryptographic algorithm is disallowed.", "The hypervisor may also shut down the virtual machine, suspend the application, notify an administrator, notify the user, notify the virtual machine, notify the application, notify an administrator of the machine or some other such action.", "In some embodiments the hypervisor may allow a grace period for the application and/or the guest computer system to remediate the violation and in others, the disallowed application may be quarantined immediately.", "As mentioned previously, the hypervisor may elect to turn on and/or turn up sampling for an application as needed.", "The hypervisor may also elect to turn on and/or turn up sampling for a user that was previously found to be executing a disallowed algorithm and/or for the virtual machine where a disallowed algorithm was previously executed.", "Similarly, the hypervisor may turn down or turn off analysis for an application that was analyzed and not found to contain any disallowed algorithms and/or data.", "FIG.", "1 illustrates an example environment 100 where one or more applications running on one or more computer systems within a computer system environment as well as the associated code running thereon may be verified by cryptographic policy enforcement implementations in accordance with at least one embodiment.", "A user 102 may connect 106 to a computer system through a computer system client device 104 and may initiate connection with or interaction with one or more applications 114 running on a host 112 operating within a computing resource service provider 110.In some embodiments, the computing resource service provider may provide a distributed, virtualized and/or datacenter environment within which one or more applications, processes, services, virtual machines and/or other such computer system entities may be executed.", "In some embodiments, the user 102 may be a person, or may be a process running on one or more remote computer systems, or may be some other computer system entity, user or process.", "The command or commands to connect to the computer system and/or to connect the applications running thereon may originate from an outside computer system and/or server, or may originate from an entity, user or process on a remote network location, or may originate from an entity, user or process within the computer system, or may originate from a user of the computer system client device 104, or may originate as a result of an automatic process or may originate as a result of a combination of these and/or other such originating entities.", "In some embodiments, the command or commands to initiate the connection 106 to the computing resource service provider 110 and/or an application 114 running thereon may be initiated by the computer system, without the intervention of a user 102.The command or commands to initiate the connection 106 to the host 112 and/or an application 114 running thereon may originate from the same origin as the command or commands to connect to the computing resource service provider 110 or may originate from another computer system and/or server, or may originate from a different entity, user or process on the same or a different remote network location, or may originate from a different entity, user or process within the computer system, or may originate from a different user of a computer system client device 104, or may originate as a result of a combination of these and/or other such same and/or different entities.", "The user 102 may request connection to the computing resource service provider via one or more connections 106 and, in some embodiments, via one or more networks 108 and/or entities associated therewith, such as servers connected to the network, either directly or indirectly.", "The computer system client device 104 that may request access to the host computer system may include any device that is capable of connecting with a computer system via a network, including at least servers, laptops, mobile devices such as smartphones or tablets, other smart devices such as smart watches, smart televisions, set-top boxes, video game consoles and other such network enabled smart devices, distributed computing systems and components thereof, abstracted components such as guest computer systems or virtual machines and/or other types of computing devices and/or components.", "The network may include, for example, a local network, an internal network, a public network such as the Internet, a wide-area network, a wireless network, a mobile network, a satellite network, a distributed computing system with a plurality of network nodes and/or the like.", "The network may also operate in accordance with various protocols, such as those listed below, Bluetooth, WiFi, cellular network protocols, satellite network protocols and/or others.", "The computing resource service provider 110 may provide access to one or more host machines as well as provide access to computer services such as virtual machine (VM) instances, automatic scaling groups, file-based database storage systems, block storage services, redundant data storage services, data archive services, data warehousing services, user access management services, content management services and/or other such computer system services as may be running thereon.", "The computing resource service provider 110 may also provide access to computer system resources such as user resources, policy resources, network resources and/or storage resources.", "In some distributed and/or virtualized computer system environments, the resources associated with the computer services may be physical devices, virtual devices, combinations of physical and/or virtual devices or other such device embodiments.", "In some embodiments, the host machines may be physical machines located within the computer system environment.", "In some embodiments, the host machines may be guest virtual machines operating on physical machines located within the computer system environment.", "The application 114 may be running within a virtual machine 120 (also referred to herein as a “VM”, a “guest virtual machine”, “a guest machine”) running on the host 112.A virtual machine is a computer system implemented in software which may be configured to execute one or more programs, services, applications, processes, modules and/or other such computer system entities.", "A virtual machine runs on a host computer system and may obtain access to host computer system hardware and resources in order to execute the one or more programs, services, applications, processes, modules and/or other such computer system entities.", "A virtual machine typically runs under the control of a controlling domain which also provides the access to host computer system hardware and resources.", "A virtual machine may be a general implementation of a computer system, with an operating system, user access, virtual memory, virtual hardware devices and/or other such computer system elements.", "A virtual machine may also be a specifically configured implementation of a computer system with only a minimal subset of the resources and capabilities that may be necessary to perform a specific task.", "The application 114 may use one or more services, processes and/or applications also running on the virtual machine 120 and/or on the host 112 to connect 118 to a system on the host machine configured to at least enforce one or more cryptographic policies on the system.", "The system that is configured to at least enforce one or more cryptographic policies (also referred to herein as the “cryptographic policy system”) may be comprised of one or more subsystems.", "The subsystems may include, but not be limited to, one or more controlling domains such as a hypervisor, one or more repositories containing computer system policies, one or more repositories containing data used in enforcing policies, one or more processes, services or applications configured to perform one or more operations relating to enforcement of computer system cryptographic policies and/or other such computer system entities.", "The cryptographic policy system may selectively sample operation of the virtual machine 120 for computer executable instructions executed by the application 114 in order to determine whether the application 114 employs cryptographic algorithms.", "If the cryptographic policy system determines that an application does employ cryptographic algorithms, the cryptographic system may then determine if those cryptographic algorithms may be allowed or disallowed by policy and if disallowed, the cryptographic policy system may take one or more remediating actions in response to the determination and policy evaluation.", "FIG.", "2 illustrates an example environment 200 where applications running within a computer system may be verified for conformance with computer system cryptographic policies as described herein at least in connection with FIG.", "1 and in accordance with at least one embodiment.", "An application 212 running on a virtual machine 208 may be one of one or more applications, including one or more other applications 210 running on the virtual machine 208.The application 212 maybe running on the virtual machine 208, which may be running on a host 204 within computing resource service provider 202 as described herein at least in connection with FIG.", "1 and in accordance with at least one embodiment.", "The virtual machine 208 may be running on the control of a controlling domain such a hypervisor 206.In an embodiment, a hypervisor is a controlling domain running on a host computer system that may provide access to computer system resources for guest virtual machine instances and their applications also running on the host computer system.", "A hypervisor typically has direct access to the host computer system resources and provides scheduled access by guests to those resources.", "For example, it is the hypervisor that provides system memory to guest computer systems and also manages that memory by reclaiming memory from the guest computer systems in the event that system memory becomes scarce.", "A hypervisor may also be called a controlling domain or domain-zero (DOM0) and typically runs as a privileged domain.", "The hypervisor 206 may monitor the computer executable instructions executed on the virtual machine 208 including, but not limited to, the computer executable instructions executed by application 212.The hypervisor 206 may monitor the computer executable instructions to at least determine whether the application 212 may be executing one or more instructions that may comprise at least a portion of an implementation of a cryptographic algorithm.", "The hypervisor 206 may make this determination by connecting to one or more policy analysis systems that may be configured to identify violations of cryptographic policy and may also be configured to enforce such policies.", "In some embodiments, the hypervisor may connect 220 to a policy analysis subsystem 216 running on the host computer system 204.The policy analysis subsystem may in turn connect to a policy repository 214, which may be one of one or more policy repositories on the host computer system 204.The policy analysis subsystem may include one or more systems configured to record and analyze executable instructions, one or more subsystems to detect cryptographic policy violations, one or more subsystems configured to respond to cryptographic policy violations and/or one or more other cryptographic policy subsystems.", "The policy repository 214 may include one or more repositories of reference cryptographic algorithm implementations, one or more repositories of system policy rules, one or more repositories of reference cryptographic data and/or one or more other cryptographic policy repositories.", "In some embodiments, the hypervisor may connect 222 to one or more cryptographic policy services 218 running within the computing resource service provider 202 on one or more other computer systems.", "The cryptographic policy services may also include a policy analysis subsystem 226 and one or more policy repositories 224.In some embodiments, the hypervisor may use a combination of on-host and off-host policy analysis subsystems and policy repositories.", "FIG.", "3 illustrates an example environment 300 where computer executable instructions may be collected and analyzed to determine whether an application may be executing instructions that may comprise at least a portion of the implementation of a cryptographic algorithm as described herein at least in connection with FIG.", "1 and in accordance with at least one embodiment.", "A hypervisor 302 may contain a trace collector 304 which may be a module, service, process, application, device or combination of these and/or other such operational computer system entities as described herein below.", "A trace collector 304 may configured to sample and record computer executable instructions and/or data referenced by the computer executable instructions, from applications running on a VM 306 which may be one of one or more VMs running on a host computer system 308.In some embodiments, the trace collector 304 may be running on the host computer system 308, within and/or under control of the hypervisor 302.The trace collector 304 may forward 310 sampled and recorded computer executable instructions to a trace analyzer 312 which may be a module, service, process, application, device or combination of these and/or other such operational computer system entities as described herein below.", "A trace analyzer 312 may be configured to receive the sampled and recorded computer executable instructions and may also be configured to begin the analysis of the sampled and recorded computer executable instructions.", "In some embodiments, the trace analyzer 312 may be running on the host computer system 308, within and/or under the control of the hypervisor 302.In some embodiments, the trace analyzer 312 may be running on a different computer system entity as described herein above.", "The trace analyzer 312 may receive the sampled and recorded computer executable instructions and may first process and then analyze the instructions by, for example, arranging them into groups and/or representing them as subgraphs and analyzing the resulting representations.", "The trace analyzer 312 may be connected 316 to and/or otherwise have access to a cryptography repository 314 which may contain data relating to one or more cryptographic algorithms that may be used to process and/or analyze the groups of instructions.", "Data in the cryptography repository may include, but not be limited to, descriptions of cryptographic algorithms, reference implementations cryptographic algorithms, example data used in cryptographic algorithms, example parameters used in cryptographic algorithms and/or other such cryptography related data.", "In some embodiments, the cryptography repository 314 may include one or more databases configured to provide organization of and/or access to the data in the cryptographic repository.", "The trace analyzer 312 may select at least a portion of the processed and analyzed instructions received from the trace collector 304 and may send these selected instruction groups 318 to a policy analyzer 322 which may be a module, service, process, application, device or combination of these and/or other such operational computer system entities as described herein below.", "A policy analyzer 322 may be configured to analyze the selected groups 318 to determine whether the selected groups comprise at least a portion of an implementation of a cryptographic algorithm.", "In some embodiments the trace analyzer 312 may also select at least a portion of the data and parameters received from the trace collector 304 and send the selected data and parameters 320 to the policy analyzer 322.The policy analyzer may be connected to 326 and/or otherwise have access to a policy repository 326 which may contain data relating to one or more system cryptographic policies.", "Data in the policy repository may include, but not be limited to, policy rules, policy mitigation strategies, policy related data, allowed lists of applications, disallowed lists of applications, allowed lists of users, disallowed lists of users and/or other such policy data.", "In some embodiments, the policy repository 324 may include one or more databases configured to provide organization of and/or access to the data in the cryptographic repository.", "The policy analyzer 322 may be connected to 330 and/or otherwise have access to the cryptography repository 314 described herein above.", "In some embodiments, the cryptography repository 314 and the policy repository 324 may be the same entity.", "As a result of analyzing the selected groups 318 and, in some embodiments, the data and parameters 320, the policy analyzer 322 may determine that an application running on the VM 306 may be executing one or more disallowed cryptographic applications.", "The policy analyzer may perform one or more operations to halt and/or otherwise mitigate the execution of the one or more disallowed cryptographic applications by sending one or more messages and/or commands 328 to the hypervisor 302.The messages and/or commands 328 may include, but not be limited to, commands to halt the application, commands to halt the virtual machine, messages to a user and/or process on the virtual machine, administrative messages to a privileged user and/or process on the virtual machine or other such messages and/or commands.", "The hypervisor 302 may be configured to at least receive and process such mitigating messages and/or command.", "As mentioned previously in this disclosure, the components described herein at least in connection with FIG.", "3 such as the trace collector 304, the trace analyzer 312 and the policy analyzer 322 may be a computer system modules, services, processes, applications, devices or combinations of these and/or other such operational computer system entities.", "In some embodiments, these components may be operational computer system entities running within and/or under the control of a controlling domain such as a hypervisor, or running within and/or under the control of a guest operating system, or running as, within and/or under the control of a separate operational computer system entity or running as, within and/or under the control of some other such computer system entity.", "Additionally, it should be understood that while this disclosure may describe the components such as the trace collector 304, the trace analyzer 312 and the policy analyzer 322 performing one or more operations, functions, processes and/or other such actions, a computer system configured in accordance with the component may be performing the described actions.", "FIG.", "4 illustrates an example process 400 for collecting and analyzing computer executable instructions to determine whether an application may be executing cryptographic algorithms as described at least in connection with FIG.", "1 and in accordance with at least one embodiment.", "A controlling domain such as the hypervisor 302 as described at least in connection with FIG.", "3 may perform some or all parts of the process illustrated in FIG.", "4.A service such as the trace collector 304 as described at least in connection with FIG.", "3 may also perform some or all parts of the process illustrated in FIG.", "4.A service such as trace analyzer 312 illustrated at least in connection with FIG.", "3 may also perform some or all parts of the process illustrated in FIG.", "4.A service such as policy analyzer 332 illustrated at least in connection with FIG.", "3 may also perform some or all parts of the process illustrated in FIG.", "4.Other services and/or processes running on a computer system may also perform some or all parts of the process illustrated in FIG.", "4 including, but not limited to, applications, processes and/or services running on host and/or virtual machines within the computer system, operating system elements of host and/or virtual machines within the computer system, dedicated network hardware on the computer system, controlling domains such as a hypervisor and/or combinations of these and/or other such operational entities within the computer system.", "A trace collector may collect traces from a virtual machine 402, including traces of computer executable instructions, parameters, data and/or other such trace data.", "The trace collector may collect instructions, parameters, data and/or other such trace data by intermittent sampling, or by constant sampling or by some other such collection method.", "A trace analyzer may then create a graph representation 404 of the traces from the virtual machine and may identify loop structures 406 using the information in the graph representation.", "If candidate loop structures are found 408, the trace analyzer may then group the computer executable instructions based on the loop structures 410.The trace analyzer may then select one or more of the groups based at least in part on shared or common data 412.The group selection may be based on data received from the trace collector, or may be based on data stored in a cryptography repository such as the cryptography repository 314 described herein at least in connection with FIG.", "3 or may be based on a combination of data from these and/or other such data sources.", "The trace analyzer may then compare the selected groups to one or more reference cryptographic algorithm implementations 414 to determine whether the selected groups comprise at least a portion of a reference cryptographic algorithm implementation.", "The reference cryptographic algorithm implementation may be stored in a cryptography repository such as the cryptography repository 314 described herein at least in connection with FIG.", "3.In some embodiments, the trace analyzer may also use data and/or parameters received from the trace collector to determine whether the selected groups comprise at least a portion of the reference cryptographic algorithm implementation.", "If it is determined that one or more of the selected groups comprise at least a portion of a reference cryptographic algorithm implementation 416, a policy may determine whether the one or more parameters associated with the selected groups should be examined 418.In some embodiments, a reference cryptographic algorithm implementation may be disallowed for all parameters, or may be disallowed for some parameters and allowed for others or may be allowed for all parameters.", "If the parameters should be examined 418, the policy analyzer may compare the parameters to allowed parameters 420.If as a result of determining that a group of instructions and optionally, the associated parameters, comprise at least a portion of a reference cryptographic algorithm implementation, the policy analyzer may determine whether one or more policies of the system prohibit 422 the execution of such an algorithm.", "If the algorithm is prohibited, the policy analyzer may direct a controlling domain such as a hypervisor to restrict 424 or mitigate the execution of the application by, for example, halting the execution of the application, halting the virtual machine or other such restricting and/or mitigating actions.", "At a number of steps in the process described herein, the process may determine whether sampling should continue 426 including, but not limited to, after no candidate loop structures are found 408, after it is determined that none of the selected groups comprise at least a portion of a reference cryptographic algorithm implementation 416, after it is determined that none of the policies of the system prohibit 422 the execution of a found cryptographic algorithm or after steps are taken to restrict 424 or mitigate the execution of the algorithm.", "FIG.", "5 illustrates an example environment 500 where a trace of a group of computer executable instructions may be represented by a graph as described herein at least in connection with FIG.", "4 and in accordance with at least one embodiment.", "A trace list 502 may include a sequential list of sampled information about one or more computer executable instructions.", "Each element in the sequential list (referred to herein simply as an “execution trace”) may contain information about a computer executable instruction that may have been executed in one or more virtual machines.", "The information about the computer executable instruction may have been collected by a computer system entity such as the trace collector 304 described herein at least in connection with FIG.", "3.Each execution trace may have been collected by the trace collector by sampling one or more memory locations as described herein above.", "The trace list 502 may be converted 506 to a trace graph 504 representation by a computer system entity such as the trace analyzer 312 described herein at least in connection with FIG.", "3.The trace graph 504 illustrated in FIG.", "5 has vertices (also referred to herein as “nodes”) corresponding to the instructions in the trace list 502 and edges corresponding to the sequential execution of the pairs of instructions.", "The directed edge between the vertex labeled “0x01” in trace graph 504 and the vertex labeled “0x02” in trace graph 504 indicates that instruction 0x02 was executed immediately after instruction 0x01 in the trace list 502 (instructions 1 and 2 in the trace list).", "Similarly, the directed edge between the vertex labeled “0x02” in trace graph 504 and the vertex labeled “0x03” in trace graph 504 indicates that instruction 0x03 was executed immediately after instruction 0x02 in the trace list 502 (instructions 2 and 3 in the trace list).", "The directed edge between the vertex labeled “0x03” in trace graph 504 and the vertex labeled “0x01” in trace graph 504 is a back edge as described herein above, representing a sequential order that may be contrary to the expected temporal order and one that, in this example, indicates a loop in the sequence of instruction execution.", "The dashed directed edge entering into the vertex labeled “0x01” in trace graph 504 indicates that instruction 0x01 is an entry point of the trace.", "The dashed directed edge exiting out of the vertex labeled “0x05” in trace graph 504 indicates that instruction 0x05 is an exit point of the trace.", "FIG.", "6 illustrates an example environment 600 where a trace of a group of computer executable instructions may be represented by a graph with multiple edges and may also be represented by a graph with weighted edges as described herein at least in connection with FIGS.", "4 and 5, and in accordance with at least one embodiment.", "The trace list 602 may be represented by the trace graph 604, with the plurality of edges (in this example, five edges) between vertex “0x01” and vertex “0x02”, between vertex “0x02” and vertex “0x03” and between vertex “0x03” and vertex “0x01”.", "There are five edges between each of these pairs of vertices in trace graph 504 because the trace list 502 contains five instances of the instruction sequence 0x01, 0x02, 0x03 and back to 0x01.The trace graph 604, with multiple edges may also be represented by the weighted trace graph 606 with weighted edges, where the five edges between, for example, vertex “0x01” and vertex “0x02” may be replaced by a single weighted edge with weight five.", "FIG.", "7 illustrates an example environment 700 where a trace graph may be analyzed by comparing it to one or more reference patterns as described herein at least in connection with FIG.", "3 and in accordance with at least one embodiment.", "A trace graph 702 such as the trace graph 604 or the weighted trace graph 606 described herein in connection with FIG.", "6 may be analyzed by a trace analyzer 704 such as the trace analyzer 312 described herein at least in connection with FIG.", "3.The trace analyzer 704 may be connected to and/or otherwise have access to a cryptography repository 706 such as the cryptography repository 314 described herein at least in connection with FIG.", "3.In some embodiments, the cryptography repository may contain one or more patterns 708 which the trace analyzer 704 may compare the trace graph 702 against.", "The comparisons of the trace graph 702 against the patterns 708 in the cryptography repository 706 may be used to determine whether the sequence of execution traces represented by the trace graph 702 corresponds to one or more of the patterns 708 and thus, whether an application running on a virtual machine that the sampled sequence of execution traces came from may be running a restricted algorithm as described herein at least in connection with FIG.", "3 and in accordance with at least one embodiment.", "In some embodiments, the trace analyzer may use one or more comparison and/or measurement techniques to determine whether the sequence of execution traces represented by the trace graph 702 corresponds to one or more of the patterns 708, how similar the sequence of execution traces represented by the trace graph 702 is to one or more of the patterns 708 and thus, how likely is it that an application running on a virtual machine that the sampled sequence of execution traces came from may be running a restricted algorithm.", "One measurement technique, an edit distance, may be used to measure the similarity between two graphs by determining, for example, the number of additions and/or deletions of vertices and/or edges that may be required to convert one graph to another.", "In the example illustrated in FIG.", "7, the edit distance between trace graph 702 and pattern 710 may be eight, the edit distance between trace graph 702 and pattern 712 may be six, the edit distance between trace graph 702 and pattern 714 may be eight and the edit distance between trace graph 702 and pattern 716 may be zero.", "The trace analyzer may use these edit distances to determine that it very likely that the application running on the virtual machine is running a restricted algorithm corresponding to pattern 716 and it is much less likely that the application running on the virtual machine is running restricted algorithms corresponding to pattern 710, pattern 712 or pattern 714.As may be contemplated, the comparison technique described herein is merely an illustrative example, and other such comparison and/or measurement techniques for determining the similarity between two graphs may be considered as within the scope of the present disclosure.", "FIG.", "8 illustrates an example environment 800 where a trace graph with parameters may be analyzed by a policy analyzer as described herein at least in connection with FIG.", "3 and in accordance with at least one embodiment.", "The trace list 802 containing instructions 804 and parameters 806 may have been analyzed by a trace analyzer as described herein at least in connection with FIG.", "3 and that analysis may have found a strong likelihood that an application running on a virtual machine where the computer executable instructions contained in trace list 802 were sampled from is running a restricted algorithm corresponding to pattern 812.A policy analyzer 808 such as the policy analyzer 322 described herein at least in connection with FIG.", "3 may have one or more policies associated with pattern 812 including, for example, the policy 810 which may contain the pattern 812 and one or more rules regarding acceptable use of the pattern 812.For example, the rule R1 814 says that, for computer executable instructions 0x01, 0x02 and 0x03, the instructions must use a certain value for parameter P1 and must use a certain value for parameter P2 and the rule R2 826 says that, for computer executable instructions 0x04 and 0x05, the instructions must use a certain value for parameter P2.In the example illustrated in FIG.", "8, five out of six of the execution traces violate the rules.", "In some embodiments, one or more violations of these rules may indicate one or more remediation actions as described herein at least in connection with FIG.", "3 and in accordance with at least one embodiment.", "As may be contemplated, the rules described herein are merely illustrative examples, and other such rules may be considered as within the scope of the present disclosure.", "FIG.", "9 illustrates an example process 900 for computing the likelihood that a group of computer executable instructions may comprise at least a portion of the implementation of a cryptographic algorithm as described herein at least in connection with FIG.", "3 and in accordance with at least one embodiment.", "A controlling domain such as the hypervisor 302 as described at least in connection with FIG.", "3 may perform some or all parts of the process illustrated in FIG.", "9.A service such as the trace collector 304 as described at least in connection with FIG.", "3 may also perform some or all parts of the process illustrated in FIG.", "9.A service such as trace analyzer 312 illustrated at least in connection with FIG.", "3 may also perform some or all parts of the process illustrated in FIG.", "9.A service such as policy analyzer 332 illustrated at least in connection with FIG.", "3 may also perform some or all parts of the process illustrated in FIG.", "9.Other services and/or processes running on a computer system may also perform some or all parts of the process illustrated in FIG.", "9 including, but not limited to, applications, processes and/or services running on host and/or virtual machines within the computer system, operating system elements of host and/or virtual machines within the computer system, dedicated network hardware on the computer system, controlling domains such as a hypervisor and/or combinations of these and/or other such operational entities within the computer system.", "A trace collector may collect one or more samples 902.A trace analyzer may, for each sample collected, determine whether the sample should be flagged 904 based on, for example, there being a certain likelihood that the sample may include one or more instructions that comprise at least a part of an algorithm such as a cryptographic algorithm and that may be restricted by one or more policies such as cryptographic policies.", "The trace analyzer may then compare the number of flagged samples to a first threshold value 906 to determine whether that number of flagged samples exceeds the first threshold value 908.If the number of flagged samples exceeds the threshold value, the trace analyzer may compute a statistical measure of whether a flagged sample was flagged 912 as described herein above.", "If that statistical measure exceeds a second threshold value 914, one or more operations may be executed by the hypervisor to restrict the algorithm.", "The statistical measure may include an average, an arithmetic mean, a median, a time-weighted average, a histogram or a combination of these and/or some other such statistical measures.", "If thresholds are not exceeded, and if it is determined that sampling should be continued 910, the trace collector may once again collect one or more samples 902.If it is determine that sampling should not continue, then sampling will stopped and/or suspended 918.FIG.", "10 illustrates aspects of an example environment 1000 for implementing aspects in accordance with various embodiments.", "As will be appreciated, although a web-based environment is used for purposes of explanation, different environments may be used, as appropriate, to implement various embodiments.", "The environment includes an electronic client device 1002, which can include any appropriate device operable to send and/or receive requests, messages or information over an appropriate network 1004 and, in some embodiments, convey information back to a user of the device.", "Examples of such client devices include personal computers, cell phones, handheld messaging devices, laptop computers, tablet computers, set-top boxes, personal data assistants, embedded computer systems, electronic book readers and the like.", "The network can include any appropriate network, including an intranet, the Internet, a cellular network, a local area network, a satellite network or any other such network and/or combination thereof.", "Components used for such a system can depend at least in part upon the type of network and/or environment selected.", "Protocols and components for communicating via such a network are well known and will not be discussed herein in detail.", "Communication over the network can be enabled by wired or wireless connections and combinations thereof.", "In this example, the network includes the Internet, as the environment includes a web server 1006 for receiving requests and serving content in response thereto, although for other networks an alternative device serving a similar purpose could be used as would be apparent to one of ordinary skill in the art.", "The illustrative environment includes at least one application server 1008 and a data store 1010.It should be understood that there can be several application servers, layers or other elements, processes or components, which may be chained or otherwise configured, which can interact to perform tasks such as obtaining data from an appropriate data store.", "Servers, as used herein, may be implemented in various ways, such as hardware devices or virtual computer systems.", "In some contexts, servers may refer to a programming module being executed on a computer system.", "As used herein, unless otherwise stated or clear from context, the term “data store” refers to any device or combination of devices capable of storing, accessing and retrieving data, which may include any combination and number of data servers, databases, data storage devices and data storage media, in any standard, distributed, virtual or clustered environment.", "The application server can include any appropriate hardware, software and firmware for integrating with the data store as needed to execute aspects of one or more applications for the client device, handling some or all of the data access and business logic for an application.", "The application server may provide access control services in cooperation with the data store and is able to generate content including, but not limited to, text, graphics, audio, video and/or other content usable to be provided to the user, which may be served to the user by the web server in the form of HyperText Markup Language (“HTML”), Extensible Markup Language (“XML”), JavaScript, Cascading Style Sheets (“CSS”) or another appropriate client-side structured language.", "Content transferred to a client device may be processed by the client device to provide the content in one or more forms including, but not limited to, forms that are perceptible to the user audibly, visually and/or through other senses including touch, taste, and/or smell.", "The handling of all requests and responses, as well as the delivery of content between the client device 1002 and the application server 1008, can be handled by the web server using PHP: Hypertext Preprocessor (“PHP”), Python, Ruby, Perl, Java, HTML, XML or another appropriate server-side structured language in this example.", "It should be understood that the web and application servers are not required and are merely example components, as structured code discussed herein can be executed on any appropriate device or host machine as discussed elsewhere herein.", "Further, operations described herein as being performed by a single device may, unless otherwise clear from context, be performed collectively by multiple devices, which may form a distributed and/or virtual system.", "The data store 1010 can include several separate data tables, databases, data documents, dynamic data storage schemes and/or other data storage mechanisms and media for storing data relating to a particular aspect of the present disclosure.", "For example, the data store illustrated may include mechanisms for storing production data 1012 and user information 1016, which can be used to serve content for the production side.", "The data store also is shown to include a mechanism for storing log data 1014, which can be used for reporting, analysis or other such purposes.", "It should be understood that there can be many other aspects that may need to be stored in the data store, such as page image information and access rights information, which can be stored in any of the above listed mechanisms as appropriate or in additional mechanisms in the data store 1010.The data store 1010 is operable, through logic associated therewith, to receive instructions from the application server 1008 and obtain, update or otherwise process data in response thereto.", "The application server 1008 may provide static, dynamic or a combination of static and dynamic data in response to the received instructions.", "Dynamic data, such as data used in web logs (blogs), shopping applications, news services and other such applications may be generated by server-side structured languages as described herein or may be provided by a content management system (“CMS”) operating on, or under the control of, the application server.", "In one example, a user, through a device operated by the user, might submit a search request for a certain type of item.", "In this case, the data store might access the user information to verify the identity of the user and can access the catalog detail information to obtain information about items of that type.", "The information then can be returned to the user, such as in a results listing on a web page that the user is able to view via a browser on the user device 1002.Information for a particular item of interest can be viewed in a dedicated page or window of the browser.", "It should be noted, however, that embodiments of the present disclosure are not necessarily limited to the context of web pages, but may be more generally applicable to processing requests in general, where the requests are not necessarily requests for content.", "Each server typically will include an operating system that provides executable program instructions for the general administration and operation of that server and typically will include a computer-readable storage medium (e.g., a hard disk, random access memory, read only memory, etc.)", "storing instructions that, when executed by a processor of the server, allow the server to perform its intended functions.", "Suitable implementations for the operating system and general functionality of the servers are known or commercially available and are readily implemented by persons having ordinary skill in the art, particularly in light of the disclosure herein.", "The environment, in one embodiment, is a distributed and/or virtual computing environment utilizing several computer systems and components that are interconnected via communication links, using one or more computer networks or direct connections.", "However, it will be appreciated by those of ordinary skill in the art that such a system could operate equally well in a system having fewer or a greater number of components than are illustrated in FIG.", "10.Thus, the depiction of the system 1000 in FIG.", "10 should be taken as being illustrative in nature and not limiting to the scope of the disclosure.", "The various embodiments further can be implemented in a wide variety of operating environments, which in some cases can include one or more user computers, computing devices or processing devices which can be used to operate any of a number of applications.", "User or client devices can include any of a number of general purpose personal computers, such as desktop, laptop or tablet computers running a standard operating system, as well as cellular, wireless and handheld devices running mobile software and capable of supporting a number of networking and messaging protocols.", "Such a system also can include a number of workstations running any of a variety of commercially-available operating systems and other known applications for purposes such as development and database management.", "These devices also can include other electronic devices, such as dummy terminals, thin-clients, gaming systems and other devices capable of communicating via a network.", "These devices also can include virtual devices such as virtual machines, hypervisors and other virtual devices capable of communicating via a network.", "Various embodiments of the present disclosure utilize at least one network that would be familiar to those skilled in the art for supporting communications using any of a variety of commercially-available protocols, such as Transmission Control Protocol/Internet Protocol (“TCP/IP”), User Datagram Protocol (“UDP”), protocols operating in various layers of the Open System Interconnection (“OSI”) model, File Transfer Protocol (“FTP”), Universal Plug and Play (“UpnP”), Network File System (“NFS”), Common Internet File System (“CIFS”) and AppleTalk.", "The network can be, for example, a local area network, a wide-area network, a virtual private network, the Internet, an intranet, an extranet, a public switched telephone network, an infrared network, a wireless network, a satellite network and any combination thereof.", "In embodiments utilizing a web server, the web server can run any of a variety of server or mid-tier applications, including Hypertext Transfer Protocol (“HTTP”) servers, FTP servers, Common Gateway Interface (“CGI”) servers, data servers, Java servers, Apache servers and business application servers.", "The server(s) also may be capable of executing programs or scripts in response to requests from user devices, such as by executing one or more web applications that may be implemented as one or more scripts or programs written in any programming language, such as Java®, C, C# or C++, or any scripting language, such as Ruby, PHP, Perl, Python or TCL, as well as combinations thereof.", "The server(s) may also include database servers, including without limitation those commercially available from Oracle °, Microsoft®, Sybase® and IBM® as well as open-source servers such as MySQL, Postgres, SQLite, MongoDB, and any other server capable of storing, retrieving and accessing structured or unstructured data.", "Database servers may include table-based servers, document-based servers, unstructured servers, relational servers, non-relational servers or combinations of these and/or other database servers.", "The environment can include a variety of data stores and other memory and storage media as discussed above.", "These can reside in a variety of locations, such as on a storage medium local to (and/or resident in) one or more of the computers or remote from any or all of the computers across the network.", "In a particular set of embodiments, the information may reside in a storage-area network (“SAN”) familiar to those skilled in the art.", "Similarly, any necessary files for performing the functions attributed to the computers, servers or other network devices may be stored locally and/or remotely, as appropriate.", "Where a system includes computerized devices, each such device can include hardware elements that may be electrically coupled via a bus, the elements including, for example, at least one central processing unit (“CPU” or “processor”), at least one input device (e.g., a mouse, keyboard, controller, touch screen or keypad) and at least one output device (e.g., a display device, printer or speaker).", "Such a system may also include one or more storage devices, such as disk drives, optical storage devices and solid-state storage devices such as random access memory (“RAM”) or read-only memory (“ROM”), as well as removable media devices, memory cards, flash cards, etc.", "Such devices also can include a computer-readable storage media reader, a communications device (e.g., a modem, a network card (wireless or wired), an infrared communication device, etc.)", "and working memory as described above.", "The computer-readable storage media reader can be connected with, or configured to receive, a computer-readable storage medium, representing remote, local, fixed and/or removable storage devices as well as storage media for temporarily and/or more permanently containing, storing, transmitting and retrieving computer-readable information.", "The system and various devices also typically will include a number of software applications, modules, services or other elements located within at least one working memory device, including an operating system and application programs, such as a client application or web browser.", "It should be appreciated that alternate embodiments may have numerous variations from that described above.", "For example, customized hardware might also be used and/or particular elements might be implemented in hardware, software (including portable software, such as applets) or both.", "Further, connection to other computing devices such as network input/output devices may be employed.", "Storage media and computer readable media for containing code, or portions of code, can include any appropriate media known or used in the art, including storage media and communication media, such as, but not limited to, volatile and non-volatile, removable and non-removable media implemented in any method or technology for storage and/or transmission of information such as computer readable instructions, data structures, program modules or other data, including RAM, ROM, Electrically Erasable Programmable Read-Only Memory (“EEPROM”), flash memory or other memory technology, Compact Disc Read-Only Memory (“CD-ROM”), digital versatile disk (DVD) or other optical storage, magnetic cassettes, magnetic tape, magnetic disk storage or other magnetic storage devices or any other medium which can be used to store the desired information and which can be accessed by the system device.", "Based on the disclosure and teachings provided herein, a person of ordinary skill in the art will appreciate other ways and/or methods to implement the various embodiments.", "The specification and drawings are, accordingly, to be regarded in an illustrative rather than a restrictive sense.", "It will, however, be evident that various modifications and changes may be made thereunto without departing from the broader spirit and scope of the invention as set forth in the claims.", "Other variations are within the spirit of the present disclosure.", "Thus, while the disclosed techniques are susceptible to various modifications and alternative constructions, certain illustrated embodiments thereof are shown in the drawings and have been described above in detail.", "It should be understood, however, that there is no intention to limit the invention to the specific form or forms disclosed, but on the contrary, the intention is to cover all modifications, alternative constructions and equivalents falling within the spirit and scope of the invention, as defined in the appended claims.", "The use of the terms “a” and “an” and “the” and similar referents in the context of describing the disclosed embodiments (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context.", "The terms “comprising,” “having,” “including” and “containing” are to be construed as open-ended terms (i.e., meaning “including, but not limited to,”) unless otherwise noted.", "The term “connected,” when unmodified and referring to physical connections, is to be construed as partly or wholly contained within, attached to or joined together, even if there is something intervening.", "Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein and each separate value is incorporated into the specification as if it were individually recited herein.", "The use of the term “set” (e.g., “a set of items”) or “subset” unless otherwise noted or contradicted by context, is to be construed as a nonempty collection comprising one or more members.", "Further, unless otherwise noted or contradicted by context, the term “subset” of a corresponding set does not necessarily denote a proper subset of the corresponding set, but the subset and the corresponding set may be equal.", "Conjunctive language, such as phrases of the form “at least one of A, B, and C,” or “at least one of A, B and C,” unless specifically stated otherwise or otherwise clearly contradicted by context, is otherwise understood with the context as used in general to present that an item, term, etc., may be either A or B or C, or any nonempty subset of the set of A and B and C. For instance, in the illustrative example of a set having three members, the conjunctive phrases “at least one of A, B, and C” and “at least one of A, B and C” refer to any of the following sets: {A}, {B}, {C}, {A, B}, {A, C}, {B, C}, {A, B, C}.", "Thus, such conjunctive language is not generally intended to imply that certain embodiments require at least one of A, at least one of B and at least one of C each to be present.", "Operations of processes described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context.", "Processes described herein (or variations and/or combinations thereof) may be performed under the control of one or more computer systems configured with executable instructions and may be implemented as code (e.g., executable instructions, one or more computer programs or one or more applications) executing collectively on one or more processors, by hardware or combinations thereof.", "The code may be stored on a computer-readable storage medium, for example, in the form of a computer program comprising a plurality of instructions executable by one or more processors.", "The computer-readable storage medium may be non-transitory.", "The use of any and all examples, or exemplary language (e.g., “such as”) provided herein, is intended merely to better illuminate embodiments of the invention and does not pose a limitation on the scope of the invention unless otherwise claimed.", "No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the invention.", "Preferred embodiments of this disclosure are described herein, including the best mode known to the inventors for carrying out the invention.", "Variations of those preferred embodiments may become apparent to those of ordinary skill in the art upon reading the foregoing description.", "The inventors expect skilled artisans to employ such variations as appropriate and the inventors intend for embodiments of the present disclosure to be practiced otherwise than as specifically described herein.", "Accordingly, the scope of the present disclosure includes all modifications and equivalents of the subject matter recited in the claims appended hereto as permitted by applicable law.", "Moreover, any combination of the above-described elements in all possible variations thereof is encompassed by the scope of the present disclosure unless otherwise indicated herein or otherwise clearly contradicted by context.", "All references, including publications, patent applications and patents, cited herein are hereby incorporated by reference to the same extent as if each reference were individually and specifically indicated to be incorporated by reference and were set forth in its entirety herein." ] ]
Patent_15876020
[ [ "SYSTEMS AND METHODS FOR REAL-TIME MEASUREMENT OF GAS CONTENT IN DRILLING FLUIDS", "Measuring the amount of individual gases in drilling fluids in real-time may be performed with optical computing devices that are calibrated in real-time or periodically with gas analysis devices to provide more accurate gas content measurements.", "In some instances, one or more drilling or completion parameters may be altered in response thereto the concentration or change in concentration of individual gases in drilling fluids." ], [ "1.A system comprising: a flow path configured to circulate a drilling fluid, the flow path comprising a degasser that includes a gas outlet fluidly coupled to a first measurement device, the first measurement device configured to produce a first output signal, a second output signal, and a third output signal corresponding to a concentration of a first gas, a second gas, and a third gas, respectively; a second measurement device and a third measurement device arranged along the flow path and configured to generate a fourth output signal and a fifth output signal, respectively, corresponding to a concentration of the first gas present in the drilling fluid and a concentration of the second gas present in the drilling fluid, respectively; and a signal processor communicably coupled to the first, second, and third measurement devices, the signal processor configured to receive the first output signal, the second output signal, the third output signal, the fourth output signal, and the fifth output signal; calculate a calibration factor based on an analysis of the first output signal relative to the fourth output signal and the second output signal relative to the fifth output signal; and apply the calibration factor to the third output signal to produce a calibrated output signal corresponding to a calibrated concentration of the third gas.", "2.The system of claim 1, wherein the degasser further comprises at least one of a drilling fluid inlet or a drilling fluid outlet, the flow path is further configured to circulate the drilling fluid into and out of a borehole penetrating a subterranean formation during a drilling operation, and the second and third measurement devices are arranged along the flow path prior to the drilling fluid inlet of the degasser.", "3.The system of claim 2, further comprising: one or more peripheral devices communicably coupled to the signal processor and configured to receive the calibrated output signal from the signal processor and report the calibrated concentration of the third gas to a well operator.", "4.The system of claim 3, wherein the one or more peripheral devices are further configured to adjust one or more parameters of the drilling operation in response to the calibrated concentration of the third gas.", "5.The system of claim 1, wherein the first measurement device comprises a first type of measurement device and the second and third measurement devices comprise a second type of measurement device that differs from the first type of measurement device.", "6.The system of claim 5, wherein the first type of measurement device comprises a gas analysis device and the second type of measurement device comprises an optical measurement device.", "7.The system of claim 1, wherein the first gas or the second gas is methane.", "8.The system of claim 1, wherein the first gas or the second gas is carbon dioxide.", "9.A method, comprising: generating a first output signal, a second output signal, and a third output signal corresponding to a concentration of a first gas, a second gas, and a third gas, respectively, with a first measurement device fluidly coupled to a gas outlet of a degasser of a flow path comprising drilling fluid; generating a fourth output signal corresponding to a concentration of the first gas present in the drilling fluid with a second measurement device and a fifth output signal corresponding to a concentration of the second gas present in the drilling fluid with a third measurement device; calculating, with a signal processor, a calibration factor based on an analysis of at least one of the first output signal relative to the fourth output signal or the second output signal relative to the fifth output signal; and applying the calibration factor to the third output signal to produce a calibrated output signal corresponding to a calibrated concentration of the third gas.", "10.The method of claim 9 further comprising: conveying the calibrated output signal to one or more peripheral devices; and adjusting one or more drilling or completion parameters in response to the calibrated concentration of the third gas.", "11.The method of claim 10, wherein adjusting the one or more drilling or completion parameters comprises altering geosteering of a drill bit.", "12.The method of claim 10, wherein adjusting the one or more drilling or completion parameters comprises at least one of changing a cementing program, changing a casing program, changing a casing design, optimizing placement of downhole perforations, sliding sleeves, and slotted liners, and optimizing isolation of zones from which production is not required.", "13.The method of claim 9, wherein the signal processor is communicably coupled to at least one of the first measurement device, the second measurement device, or the third measurement device.", "14.The method of claim 9, wherein the first measurement device is a first type of measurement device and the second and third measurement devices are a second type of measurement device that differs from the first type of measurement device.", "15.The method of claim 9, wherein the flow path extends into and out of a borehole penetrating a subterranean formation, the flow path includes the degasser having a drilling fluid inlet, a drilling fluid outlet, and the gas outlet, and the method further comprises: circulating the drilling fluid within the flow path during drilling operations.", "16.The method of claim 15, wherein the first gas and the second gas are from the subterranean formation.", "17.The method of claim 9, wherein the first gas or the second gas is methane.", "18.The method of claim 9, wherein the first gas or the second gas is carbon dioxide.", "19.A device comprising: at least one processor configured to: receive, from a first measurement device fluidly coupled to a gas outlet of a degasser of a flow path comprising drilling fluid, a first output signal, a second output signal, and a third output signal corresponding to a concentration of a first gas, a second gas, and a third gas, respectively; receive, from a second measurement device, a fourth output signal corresponding to a concentration of the first gas present in the drilling fluid and; receive, from a third measurement device, a fifth output signal corresponding to a concentration of the second gas present in the drilling fluid; calculate a calibration factor based on an analysis of at least one of the first output signal relative to the fourth output signal or the second output signal relative to the fifth output signal; and facilitate applying the calibration factor to the third output signal to produce a calibrated output signal corresponding to a calibrated concentration of the third gas.", "20.The device of claim 19, wherein the second and third measurement devices are arranged along the flow path prior to a drilling fluid inlet of the degasser, the first measurement device is a first type of measurement device and the second and third measurement devices are a second type of measurement device that differs from the first type of measurement device." ], [ "<SOH> BACKGROUND <EOH>The present disclosure relates to systems and methods for measuring the gas content in drilling fluids.", "During the drilling of a hydrocarbon-producing well, a drilling fluid or “mud” is continuously circulated from the surface down to the bottom of the wellbore being drilled and back to the surface again.", "The drilling fluid serves several functions, one of them being to transport wellbore cuttings up to the surface where they are separated from the drilling fluid.", "Another function of the drilling fluid is to cool the drill bit and provide hydrostatic pressure on the walls of the drilled borehole to prevent wellbore collapse and the resulting influx of gas or liquid from the formations being drilled.", "Analyzing the drilling fluid as it returns to the surface is recognized in the oil and gas industry as an important first appraisal of a potential hydrocarbon-bearing reservoir zone, thereby providing important data to guide subsequent evaluation and testing.", "Such analysis and testing is commonly referred to as “mud logging” analysis.", "Through mud logging, reservoir zones can be evaluated while they are being initially penetrated by measuring the formation gases present in the drilling fluid as it returns to the surface.", "The presence and concentration of hydrocarbon and non-hydrocarbon gases in drilling fluids relative to the depth can be used in designing stimulation operations and production operations, as well as in the assessment.", "Mud logging analysis of drilling fluids is typically conducted off-line using laboratory analyses which require the extraction of a sample of the drilling fluid and a subsequent controlled testing procedure usually conducted at a separate location.", "Because the characteristics of the extracted sample of the drilling fluid often changes during the lag time between collection and analysis, off-line, retrospective analyses can be unsatisfactory for determining true characteristics of a drilling fluid.", "Additionally, some mud logging analyses take hours to days to complete.", "Therefore, the drilling operation is often finished prior to completion of the analysis.", "As a result, proactive control of drilling operations cannot take place, at least without significant process disruption occurring while awaiting the results of the mud logging analyses." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>The following figures are included to illustrate certain aspects of the present disclosure, and should not be viewed as exclusive embodiments.", "The subject matter disclosed is capable of considerable modifications, alterations, combinations, and equivalents in form and function, as will occur to those skilled in the art and having the benefit of this disclosure.", "FIG.", "1 illustrates an exemplary integrated computation element, according to one or more embodiments.", "FIG.", "2 illustrates an exemplary optical computing device for monitoring a fluid, according to one or more embodiments.", "FIG.", "3 illustrates another exemplary optical computing device for monitoring a fluid, according to one or more embodiments.", "FIG.", "4 illustrates an exemplary wellbore drilling assembly that may employ one or more optical computing devices for monitoring a fluid, according to one or more embodiments.", "FIG.", "5 provides an illustrative representation of a portion of a system suitable for deriving a dual point correction factor for the gas composition of a fluid, according to one or more embodiments.", "FIG.", "6 illustrates an exemplary wellbore drilling assembly that with optical computing devices in order to monitor a drilling fluid or a completion fluid, according to one or more embodiments.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "BACKGROUND The present disclosure relates to systems and methods for measuring the gas content in drilling fluids.", "During the drilling of a hydrocarbon-producing well, a drilling fluid or “mud” is continuously circulated from the surface down to the bottom of the wellbore being drilled and back to the surface again.", "The drilling fluid serves several functions, one of them being to transport wellbore cuttings up to the surface where they are separated from the drilling fluid.", "Another function of the drilling fluid is to cool the drill bit and provide hydrostatic pressure on the walls of the drilled borehole to prevent wellbore collapse and the resulting influx of gas or liquid from the formations being drilled.", "Analyzing the drilling fluid as it returns to the surface is recognized in the oil and gas industry as an important first appraisal of a potential hydrocarbon-bearing reservoir zone, thereby providing important data to guide subsequent evaluation and testing.", "Such analysis and testing is commonly referred to as “mud logging” analysis.", "Through mud logging, reservoir zones can be evaluated while they are being initially penetrated by measuring the formation gases present in the drilling fluid as it returns to the surface.", "The presence and concentration of hydrocarbon and non-hydrocarbon gases in drilling fluids relative to the depth can be used in designing stimulation operations and production operations, as well as in the assessment.", "Mud logging analysis of drilling fluids is typically conducted off-line using laboratory analyses which require the extraction of a sample of the drilling fluid and a subsequent controlled testing procedure usually conducted at a separate location.", "Because the characteristics of the extracted sample of the drilling fluid often changes during the lag time between collection and analysis, off-line, retrospective analyses can be unsatisfactory for determining true characteristics of a drilling fluid.", "Additionally, some mud logging analyses take hours to days to complete.", "Therefore, the drilling operation is often finished prior to completion of the analysis.", "As a result, proactive control of drilling operations cannot take place, at least without significant process disruption occurring while awaiting the results of the mud logging analyses.", "BRIEF DESCRIPTION OF THE DRAWINGS The following figures are included to illustrate certain aspects of the present disclosure, and should not be viewed as exclusive embodiments.", "The subject matter disclosed is capable of considerable modifications, alterations, combinations, and equivalents in form and function, as will occur to those skilled in the art and having the benefit of this disclosure.", "FIG.", "1 illustrates an exemplary integrated computation element, according to one or more embodiments.", "FIG.", "2 illustrates an exemplary optical computing device for monitoring a fluid, according to one or more embodiments.", "FIG.", "3 illustrates another exemplary optical computing device for monitoring a fluid, according to one or more embodiments.", "FIG.", "4 illustrates an exemplary wellbore drilling assembly that may employ one or more optical computing devices for monitoring a fluid, according to one or more embodiments.", "FIG.", "5 provides an illustrative representation of a portion of a system suitable for deriving a dual point correction factor for the gas composition of a fluid, according to one or more embodiments.", "FIG.", "6 illustrates an exemplary wellbore drilling assembly that with optical computing devices in order to monitor a drilling fluid or a completion fluid, according to one or more embodiments.", "DETAILED DESCRIPTION The present disclosure relates to systems and methods for measuring the gas content in drilling fluids in real-time using optical computing devices that can be calibrated in real-time, which may provide for more accurate gas content measurements.", "The gas content measurements may be used for adjusting one or more drilling parameters in response thereto.", "The exemplary systems and methods described herein employ various configurations and arrangements of optical computing devices, also commonly referred to as “opticoanalytical devices,” for the real-time or near real-time analysis of a material of interest.", "In operation, the exemplary systems and methods may be useful and otherwise advantageous in determining one or more properties or characteristics of the fluid, such as the type and concentration of one or more gases present within the fluid.", "This may allow for qualitative and/or quantitative analyses of the fluid to occur without having to extract a sample and undertake time-consuming analyses of the sample at an off-site laboratory, which may be particularly advantageous in real-time mud logging.", "The systems and methods disclosed herein may be suitable for use in the oil and gas industry since the described optical computing devices provide a cost-effective, rugged, and accurate means for monitoring oil/gas-related fluids, such as drilling fluids.", "In particular, the systems and methods may prove advantageous for use in mud logging gas analysis, thereby providing a stream of continuous data on the hydrocarbon and non-hydrocarbon gas species that may be encountered while drilling into subterranean formations.", "When the drilling fluid returns to the surface, for example, it may contain hydrocarbons (and other compounds) contained within the rock that has been drilled as well as additional hydrocarbons that have leaked into the wellbore from the surrounding rock formation.", "The real-time measurement of the abundance of these gas compounds will yield information on the hydrocarbon content of the rock.", "However, in some instances, it may be difficult to measure some gas species present in the drilling fluid, for example, because of a low concentration of the gas of interest, because of a high concentration of another gas (e.g., methane) that interferes with detection (e.g., having an overlapping spectrum), or a combination thereof.", "Accordingly, in some instances, optical computing devices optionally in combination with other analytical devices may be used for analyzing of reference gases in the drilling fluid and each gas of interest in the gas extracted from the drilling fluid.", "Then, the concentration of the reference gases in the drilling fluid and in the extracted gas can be compared and related with a correction factor or correction function.", "Then, the correction factor/function may be used to extrapolate the concentration of each gas of interest in the drilling fluid from the concentration of each gas of interest in the extracted gas.", "Such methods or similar methods may provide more accurate mud logging in real-time at the well site.", "In some embodiments, analysis of the gas extracted from the drilling fluid may be performed on the surface, outside of the stringent downhole environmental conditions (high pressure, high temperature, and strong vibrations).", "Accordingly, specialized and sophisticated measurement techniques may be available to analyze the extracted gas, such as optical measurement techniques, gas chromatography, and the like.", "Moreover, a plurality of measurement techniques may be used at the surface on the extracted gas sample when the signals from two different compounds interfere with one another using a single measurement technique.", "For example, when the optical signature of two compounds interferes with one another, a gas chromatographer may be able to distinctly separate each of the two compounds and provide a precise measurement value for the two.", "In this regard, systems and methods consistent with the present disclosure enable obtaining a measurement of a gas concentration in the drilling fluid at the downhole location, based on the measurement of the gas concentration in the extracted gas at the surface.", "Information regarding the hydrocarbon content of the rock may be provided to a well operator for interpretation and consideration and, if required, the well operator may alter various drilling or completion parameters in response thereto.", "For instance, depending on what types and concentrations of gases are detected within the rock being drilled, a well operator may adjust production valves and/or choke settings in order to regulate the progress of the drilling operation and also minimize wellbore kick through early kick detection.", "In other cases, the well operator may alter mud properties in an effort to optimize drilling efficiency or formation evaluation efficiency.", "Other drilling and completion parameters that may be altered by a well operator upon consideration of the data include changing a planned cementing and/or casing program and optimizing a well completion design.", "In some cases, the data may reveal excessive amounts of hazardous or otherwise toxic gases being returned to the surface.", "Such gases may pose a potential health hazard to rig workers and the surrounding environment.", "In such cases, the well operator may proactively reduce the amount of hazardous/toxic gases by introducing one or more remedial additives or components to the drilling fluid.", "In other cases, the data may indicate an increased amount of viable hydrocarbons in the drilled borehole, such as in a particular lateral trajectory of the wellbore.", "In such cases, the well operator may manipulate the well plan and/or geosteering so that the resulting wellbore is formed substantially in and through the observed hydrocarbon-rich strata or region.", "In other words, the planned trajectory of the well path may be manipulated or otherwise altered by geosteering the drilling equipment such that the borehole penetrates a larger portion of the hydrocarbon-rich strata than would have otherwise been penetrated.", "As used herein, the term “fluid” refers to any substance that is capable of flowing, including particulate solids, liquids, gases, slurries, emulsions, powders, muds, mixtures, combinations thereof, and the like.", "In some embodiments, the fluid is a drilling fluid or drilling “mud,” including water-based drilling fluids, oil-based drilling fluids, synthetic drilling fluids, and the like.", "In other embodiments, the fluid may be a completion fluid or a clean-up fluid such as, but not limited to, fresh water, saltwater (e.g., water containing one or more salts dissolved therein), brine (e.g., saturated salt water, chloride salts, bromide salts, combinations thereof, etc.", "), seawater, a spacer fluid, base fluids, or other treatment fluids known in the art.", "As used herein, the term “characteristic” refers to a chemical, mechanical, or physical property of the fluid.", "A characteristic of the fluid may include a quantitative value or concentration of one or more chemical constituents or compounds present within the fluid.", "Such chemical constituents may be referred to herein as “analytes.” Illustrative characteristics of a substance that can be monitored with the optical computing devices disclosed herein can include, for example, chemical composition (e.g., identity and concentration in total or of individual components or compounds), phase presence (e.g., gas, oil, water, etc.", "), impurity content, pH, alkalinity, viscosity, density, ionic strength, total dissolved solids, salt content (e.g., salinity), porosity, opacity, bacterial content, total hardness, combinations thereof, state of matter (solid, liquid, gas, emulsion, mixtures, etc.", "), and the like.", "Moreover, the phrase “characteristic of interest of/in a fluid” may be used herein to refer to the concentration or characteristic of a gas contained in or otherwise entrained within the fluid.", "Exemplary gases that may be monitored or otherwise measured with the optical computing devices as contained within a drilling fluid, for example, include, but are not limited to, methane, ethane, propane, n-butane, n-pentane, iso-butane, iso-pentane, neo-pentane, benzene, toluene, carbon dioxide, carbon monoxide, hydrogen sulfide, acetic acid, argon, helium, oxygen, nitrogen, water, hydrogen, carbonyl sulfide, carbon disulfide, and any combination thereof.", "As used herein, the term “flow path” refers to a route through which a fluid is capable of being transported between at least two points.", "In some cases, the flow path need not be continuous or otherwise contiguous between the two points.", "Exemplary flow paths include, but are not limited to, a flow line, a pipeline, production tubing, drill string, work string, casing, a wellbore, an annulus defined between a wellbore and any tubular arranged within the wellbore, a mud pit, a subterranean formation, etc., combinations thereof, or the like.", "It should be noted that the term “flow path” does not necessarily imply that a fluid is flowing therein, rather that a fluid is capable of being transported or otherwise flowable therethrough.", "As used herein, the term “electromagnetic radiation” refers to radio waves, microwave radiation, infrared and near-infrared radiation, visible light, ultraviolet light, X-ray radiation and gamma ray radiation.", "As used herein, the term “optical computing device” refers to an optical device that is configured to receive an input of electromagnetic radiation associated with a fluid and produce an output of electromagnetic radiation from a processing element arranged within the optical computing device.", "The processing element may be, for example, an integrated computational element (ICE), also known as a multivariate optical element (MOE), used in the optical computing device.", "The electromagnetic radiation that optically interacts with the processing element is changed so as to be readable by a detector, such that an output of the detector can be correlated to a characteristic of the fluid, such as the type and concentration of a gas in the fluid.", "The output of electromagnetic radiation from the processing element can be reflected electromagnetic radiation, transmitted electromagnetic radiation, and/or dispersed electromagnetic radiation.", "Whether the detector analyzes reflected, transmitted, or dispersed electromagnetic radiation may be dictated by the structural parameters of the optical computing device as well as other considerations known to those skilled in the art.", "In addition, emission and/or scattering of the fluid, for example via fluorescence, luminescence, Raman, Mie, and/or Raleigh scattering, can also be monitored by the optical computing devices.", "As used herein, the term “optically interact” or variations thereof refers to the reflection, transmission, scattering, diffraction, or absorption of electromagnetic radiation either on, through, or from one or more processing elements (i.e., integrated computational elements or multivariate optical elements), a fluid, or a gas present within the fluid.", "Accordingly, optically interacted light refers to electromagnetic radiation that has been reflected, transmitted, scattered, diffracted, or absorbed by, emitted, or re-radiated, for example, using a processing element, but may also apply to interaction with a fluid or a gas entrained within the fluid.", "The exemplary systems and methods described herein will include at least one optical computing device arranged along or in a flow path in order to monitor a fluid contained therein.", "Each optical computing device may include an electromagnetic radiation source, at least one processing element (e.g., an integrated computational element), and at least one detector arranged to receive optically interacted light from the at least one processing element or the fluid.", "In some embodiments, the exemplary optical computing devices may be specifically configured for detecting, analyzing, and quantitatively measuring a particular characteristic of the fluid, such as the type and concentration of a gas present within the fluid.", "In other embodiments, the optical computing devices may be general purpose optical devices, with post-acquisition processing (e.g., through computer means) being used to specifically detect the characteristic of the fluid.", "The presently described optical computing devices can perform calculations (analyses) in real-time or near real-time without the need for time-consuming sample processing.", "Moreover, the optical computing devices can be specifically configured to detect and analyze particular characteristics of a fluid or a gas present within the fluid.", "As a result, interfering signals are discriminated from those of interest in the fluid by appropriate configuration of the optical computing devices, such that the optical computing devices provide a rapid response regarding the characteristics of the fluid as based on the detected output.", "In some embodiments, the detected output can be converted into a voltage that is distinctive of the magnitude of the characteristic of the fluid.", "The optical computing devices can be configured to detect not only the composition and concentrations of a gas within a fluid, but they also can be configured to determine physical properties and other characteristics of the fluid and/or the gas based on an analysis of the electromagnetic radiation received from the fluid and/or the gas.", "For example, the optical computing devices can be configured to determine the concentration of an analyte and correlate the determined concentration to a characteristic of the fluid.", "As will be appreciated, the optical computing devices may be configured to detect as many characteristics (e.g., gas compounds and their respective concentrations) of the fluid as desired.", "All that is required to accomplish the monitoring of multiple characteristics is the incorporation of suitable processing and detection means within the optical computing device for each characteristic.", "In some embodiments, the properties of the fluid can be a combination of the properties of the analytes therein (e.g., a linear, non-linear, logarithmic, and/or exponential combination).", "Accordingly, the more characteristics and analytes that are detected and analyzed using the optical computing devices, the more accurately the properties of the given fluid and/or gas will be determined.", "The optical computing devices described herein utilize electromagnetic radiation to perform calculations, as opposed to the hardwired circuits of conventional electronic processors.", "When electromagnetic radiation interacts with a fluid, unique physical and chemical information about the fluid is encoded in the electromagnetic radiation that is reflected from, transmitted through, or radiated from the fluid.", "This information is often referred to as the spectral “fingerprint” of the fluid.", "The optical computing devices described herein are capable of extracting the information of the spectral fingerprint of multiple characteristics or analytes within a fluid, and converting that information into a detectable output relating to one or more characteristics of the fluid or a gas present within the fluid.", "That is, through suitable configurations of the optical computing devices, electromagnetic radiation associated with a characteristic or analyte of interest of a fluid can be separated from electromagnetic radiation associated with all other components of the fluid in order to estimate the properties of the fluid in real-time or near real-time.", "The processing elements used in the exemplary optical computing devices described herein may be characterized as integrated computational elements (ICE).", "Each ICE is capable of distinguishing electromagnetic radiation related to the characteristic of interest from electromagnetic radiation related to other components of a fluid.", "Referring to FIG.", "1, illustrated is an exemplary ICE 100 suitable for use in the optical computing devices used in the systems and methods described herein.", "As illustrated, the ICE 100 may include a plurality of alternating layers 102 and 104, such as silicon (Si) and SiO2 (quartz), respectively.", "In general, these layers 102, 104 consist of materials whose index of refraction is high and low, respectively.", "Other examples might include niobia and niobium, germanium and germania, MgF, SiO, and other high and low index materials known in the art.", "The layers 102, 104 may be strategically deposited on an optical substrate 106.In some embodiments, the optical substrate 106 is BK-7 optical glass.", "In other embodiments, the optical substrate 106 may be another type of optical substrate, such as quartz, sapphire, silicon, germanium, zinc selenide, zinc sulfide, or various plastics such as polycarbonate, polymethylmethacrylate (PMMA), polyvinylchloride (PVC), diamond, ceramics, combinations thereof, and the like.", "At the opposite end (e.g., opposite the optical substrate 106 in FIG.", "1), the ICE 100 may include a layer 108 that is generally exposed to the environment of the device or installation.", "The number of layers 102, 104 and the thickness of each layer 102, 104 are determined from the spectral attributes acquired from a spectroscopic analysis of a characteristic of the fluid using a conventional spectroscopic instrument.", "The spectrum of interest of a given characteristic typically includes any number of different wavelengths.", "It should be understood that the exemplary ICE 100 in FIG.", "1 does not in fact represent any particular characteristic of a given fluid, but is provided for purposes of illustration only.", "Consequently, the number of layers 102, 104 and their relative thicknesses, as shown in FIG.", "1, bear no correlation to any particular characteristic.", "Nor are the layers 102, 104 and their relative thicknesses necessarily drawn to scale, and therefore should not be considered limiting of the present disclosure.", "Moreover, those skilled in the art will readily recognize that the materials that make up each layer 102, 104 (i.e., Si and SiO2) may vary, depending on the application, cost of materials, and/or applicability of the material to the given fluid.", "In some embodiments, the material of each layer 102, 104 can be doped or two or more materials can be combined in a manner to achieve the desired optical characteristic.", "In addition to solids, the exemplary ICE 100 may also contain liquids and/or gases, optionally in combination with solids, in order to produce a desired optical characteristic.", "In the case of gases and liquids, the ICE 100 can contain a corresponding vessel (not shown), which houses the gases or liquids.", "Exemplary variations of the ICE 100 may also include holographic optical elements, gratings, piezoelectric, light pipe, digital light pipe (DLP), and/or acousto-optic elements, for example that can create transmission, reflection, and/or absorptive properties of interest.", "The multiple layers 102, 104 exhibit different refractive indices.", "By properly selecting the materials of the layers 102, 104 and their relative thickness and spacing, the ICE 100 may be configured to selectively pass/reflect/refract predetermined fractions of electromagnetic radiation at different wavelengths.", "Each wavelength is given a predetermined weighting or loading factor.", "The thickness and spacing of the layers 102, 104 may be determined using a variety of approximation methods from the spectrograph of the characteristic or analyte of interest.", "These methods may include inverse Fourier transform (IFT) of the optical transmission spectrum and structuring the ICE 100 as the physical representation of the IFT.", "The approximations convert the IFT into a structure based on known materials with constant refractive indices.", "The weightings that the layers 102, 104 of the ICE 100 apply at each wavelength are set to the regression weightings described with respect to a known equation, or data, or spectral signature.", "Briefly, the ICE 100 may be configured to perform the dot product of the input light beam into the ICE 100 and a desired loaded regression vector represented by each layer 102, 104 for each wavelength.", "As a result, the output light intensity of the ICE 100 is related to the characteristic or analyte of interest.", "Referring now to FIG.", "2, illustrated is an exemplary optical computing device 200 for monitoring a fluid 202, according to one or more embodiments.", "In the illustrated embodiment, the fluid 202 may be contained or otherwise flowing within an exemplary flow path 204.The flow path 204 may be a flow line, a pipeline, a wellbore, an annulus defined within a wellbore, or any flow lines or pipelines extending to/from a wellbore.", "The fluid 202 present within the flow path 204 may be flowing in the general direction indicated by the arrows A (i.e., from upstream to downstream).", "Portions of the flow path 204 may be arranged substantially vertical, substantially horizontal, or any directional configuration therebetween, without departing from the scope of the disclosure.", "The optical computing device 200 may be configured to determine a characteristic of interest in the fluid 202, such as the type and/or concentration of a gas present within the fluid 202.In some embodiments, the device 200 may include an electromagnetic radiation source 208 configured to emit or otherwise generate electromagnetic radiation 210.The electromagnetic radiation source 208 may be any device capable of emitting or generating electromagnetic radiation, as defined herein.", "For example, the electromagnetic radiation source 208 may be a light bulb, a light emitting diode (LED), a laser, a blackbody, a photonic crystal, an X-Ray source, combinations thereof, or the like.", "In some embodiments, a lens 212 may be configured to collect or otherwise receive the electromagnetic radiation 210 and direct a beam 214 of electromagnetic radiation 210 toward the fluid 202.The lens 212 may be any type of optical device configured to transmit or otherwise convey the electromagnetic radiation 210 as desired, such as a normal lens, a Fresnel lens, a diffractive optical element, a holographic graphical element, a mirror (e.g., a focusing mirror), or a type of collimator.", "In other embodiments, the lens 212 may be omitted from the device 200 and the electromagnetic radiation 210 may instead be directed toward the fluid 202 directly from the electromagnetic radiation source 208.In one or more embodiments, the device 200 may also include a sampling window 216 arranged adjacent to or otherwise in contact with the fluid 202 for detection purposes.", "The sampling window 216 may be made from a variety of transparent, rigid or semi-rigid materials that are configured to allow transmission of the electromagnetic radiation 210 therethrough.", "For example, the sampling window 216 may be made of, but is not limited to, glasses, plastics, semi-conductors, crystalline materials, polycrystalline materials, hot or cold-pressed powders, combinations thereof, or the like.", "After passing through the sampling window 216, the electromagnetic radiation 210 impinges upon and optically interacts with the fluid 202.As a result, optically interacted radiation 218 is generated by and reflected from the fluid 202.Those skilled in the art, however, will readily recognize that alternative variations of the device 200 may allow the optically interacted radiation 218 to be generated by being transmitted, scattered, diffracted, absorbed, emitted, or re-radiated by and/or from the fluid 202, without departing from the scope of the disclosure.", "The optically interacted radiation 218 generated by the interaction with the fluid 202 may be directed to or otherwise be received by an ICE 220 arranged within the device 200.The ICE 220 may be a spectral component substantially similar to the ICE 100 described above with reference to FIG.", "1.Accordingly, in operation the ICE 220 may be configured to receive the optically interacted radiation 218 and produce modified electromagnetic radiation 222 corresponding to a particular characteristic of the fluid 202.In particular, the modified electromagnetic radiation 222 is electromagnetic radiation that has optically interacted with the ICE 220, whereby an approximation of the regression vector corresponding to the characteristic of the fluid 202 is obtained.", "While FIG.", "2 depicts the ICE 220 as receiving reflected electromagnetic radiation from the fluid 202, the ICE 220 may be arranged at any point along the optical train of the device 200, without departing from the scope of the disclosure.", "For example, in one or more embodiments, the ICE 220 (as shown in dashed lines) may be arranged within the optical train prior to the sampling window 216 and equally obtain substantially the same results.", "In other embodiments, the ICE 220 may generate the modified electromagnetic radiation 222 through reflection, instead of transmission therethrough.", "Moreover, while only one ICE 220 is shown in the device 200, embodiments are contemplated herein which include the use of at least two ICE components in the device 200 configured to cooperatively determine the characteristic of interest in the fluid 202.For example, two or more ICE may be arranged in series or parallel within the device 200 and configured to receive the optically interacted radiation 218 and thereby enhance sensitivities and detector limits of the device 200.In other embodiments, two or more ICE may be arranged on a movable assembly, such as a rotating disc or an oscillating linear array, which moves such that individual ICE components are able to be exposed to or otherwise optically interact with electromagnetic radiation for a distinct brief period of time.", "The two or more ICE components in any of these embodiments may be configured to be either associated or disassociated with the characteristic of interest in the fluid 202.In other embodiments, the two or more ICE may be configured to be positively or negatively correlated with the characteristic of interest in the fluid 202.In some embodiments, it may be desirable to monitor more than one characteristic of interest at a time using the device 200, such as detecting multiple types or compounds of gases within the fluid 202.In such embodiments, various configurations for multiple ICE components can be used, where each ICE component is configured to detect a particular and/or distinct characteristic of interest.", "In some embodiments, the characteristic can be analyzed sequentially using multiple ICE components that are provided a single beam of electromagnetic radiation being reflected from or transmitted through the fluid 202.In some embodiments, multiple ICE components can be arranged on a rotating disc, where the individual ICE components are only exposed to the beam of electromagnetic radiation for a short time.", "Advantages of this approach can include the ability to analyze multiple characteristics of the fluid 202 using a single optical computing device 200 and the opportunity to assay additional characteristics (e.g., types or compounds of gases within the fluid 202) simply by adding additional ICE components to the rotating disc.", "In other embodiments, multiple optical computing devices can be placed at a single location along the flow path 204, where each optical computing device contains a unique ICE that is configured to detect a particular characteristic of interest in the fluid 202.In such embodiments, a beam splitter can divert a portion of the electromagnetic radiation being reflected by, emitted from, or transmitted through the fluid 202 and into each optical computing device.", "Each optical computing device, in turn, can be coupled to a corresponding detector or detector array that is configured to detect and analyze an output of electromagnetic radiation from the respective optical computing device.", "Parallel configurations of optical computing devices can be particularly beneficial for applications that require low power inputs and/or no moving parts.", "Those skilled in the art will appreciate that any of the foregoing configurations can further be used in combination with a series configuration in any of the present embodiments.", "For example, two optical computing devices having a rotating disc with a plurality of ICE components arranged thereon can be placed in series for performing an analysis at a single location along the length of the flow path 204.Likewise, multiple detection stations, each containing optical computing devices in parallel, can be placed in series for performing a similar analysis.", "The modified electromagnetic radiation 222 generated by the ICE 220 may subsequently be conveyed to a detector 224 for quantification of the signal.", "The detector 224 may be any device capable of detecting electromagnetic radiation, and may be generally characterized as an optical transducer.", "In some embodiments, the detector 224 may be, but is not limited to, a thermal detector such as a thermopile or photoacoustic detector, a semiconductor detector, a piezo-electric detector, a charge coupled device (CCD) detector, a video or array detector, a split detector, a photon detector (such as a photomultiplier tube), photodiodes, combinations thereof, or the like, or other detectors known to those skilled in the art.", "In some embodiments, the detector 224 may be configured to produce an output signal 226 in real-time or near real-time in the form of a voltage (or current) that corresponds to the particular characteristic of interest in the fluid 202.The voltage returned by the detector 224 is essentially the dot product of the optical interaction of the optically interacted radiation 218 with the respective ICE 220 as a function of the concentration of the characteristic of interest of the fluid 202.As such, the output signal 226 produced by the detector 224 and the concentration of the characteristic may be related, for example, directly proportional.", "In other embodiments, however, the relationship may correspond to a polynomial function, an exponential function, a logarithmic function, and/or a combination thereof.", "In some embodiments, the device 200 may include a second detector 228, which may be similar to the first detector 224 in that it may be any device capable of detecting electromagnetic radiation.", "The second detector 228 may be used to detect radiating deviations stemming from the electromagnetic radiation source 208.Undesirable radiating deviations can occur in the intensity of the electromagnetic radiation 210 due to a wide variety of reasons and potentially causing various negative effects on the device 200.These negative effects can be particularly detrimental for measurements taken over a period of time.", "In some embodiments, radiating deviations can occur as a result of a build-up of film or material on the sampling window 216 which has the effect of reducing the amount and quality of light ultimately reaching the first detector 224.Without proper compensation, such radiating deviations could result in false readings and the output signal 226 would no longer be primarily or accurately related to the characteristic of interest.", "To compensate for these types of undesirable effects, the second detector 228 may be configured to generate a compensating signal 230 generally indicative of the radiating deviations of the electromagnetic radiation source 208, and thereby normalize the output signal 226 generated by the first detector 224.As illustrated, the second detector 228 may be configured to receive a portion of the optically interacted radiation 218 via a beamsplitter 232 in order to detect the radiating deviations.", "In other embodiments, however, the second detector 228 may be arranged to receive electromagnetic radiation from any portion of the optical train in the device 200 in order to detect the radiating deviations, without departing from the scope of the disclosure.", "In some applications, the output signal 226 and the compensating signal 230 may be conveyed to or otherwise received by a signal processor 234 communicably coupled to both the detectors 224, 228.The signal processor 234 may be a computer including a processor and a machine-readable storage medium having instructions stored thereon, which, when executed by the processor 234, cause the optical computing device 200 to perform a number of operations, such as determining a characteristic of interest of the fluid 202.For instance, the concentration of each characteristic detected with the optical computing device 200 can be fed into an algorithm operated by the signal processor 234.The algorithm can be part of an artificial neural network configured to use the concentration of each detected characteristic in order to evaluate the overall characteristic(s) or quality of the fluid 202.The signal processor 234 may also be configured to computationally combine the compensating signal 230 with the output signal 226 in order to normalize the output signal 226 in view of any radiating deviations detected by the second detector 228.Computationally combining the output and compensating signals 226, 230 may entail computing a ratio of the two signals 226, 230.For example, the concentration or magnitude of each characteristic determined using the optical computing device 200 can be fed into an algorithm run by the signal processor 234.The algorithm may be configured to make predictions on how the characteristics of the fluid 202 change if the concentrations of one or more components or additives are changed relative to one another.", "In real-time or near real-time, the signal processor 234 may be configured to provide a resulting output signal 236 corresponding to the characteristic of interest in the fluid 202, such as the concentration of a gas present in the fluid 202.The resulting output signal 236 may be readable by an operator who can consider the results and make proper adjustments or take appropriate action, if needed.", "In some embodiments, the resulting signal output 236 may be conveyed, either wired or wirelessly, to an operator for consideration.", "In other embodiments, the resulting output signal 236 may be recognized by the signal processor 234 as being within or without a predetermined or preprogrammed range of suitable operation and may alert the operator of an out of range reading so appropriate corrective action may be taken, or otherwise autonomously undertake the appropriate corrective action such that the resulting output signal 236 returns to a value within the predetermined or preprogrammed range of suitable operation.", "Referring now to FIG.", "3, illustrated is another exemplary optical computing device 300 for monitoring the fluid 202, according to one or more embodiments.", "The optical computing device 300 may be similar in some respects to the optical computing device 200 of FIG.", "2, and therefore may be best understood with reference thereto where like numerals indicate like elements that will not be described again.", "Again, the optical computing device 300 may be configured to determine the concentration of a characteristic of interest in the fluid 202, such as the concentration of a gas within the fluid 202, as contained within the flow path 204.Unlike the device 200 of FIG.", "2, however, the optical computing device 300 in FIG.", "3 may be configured to transmit the electromagnetic radiation 210 through the fluid 202 via a first sampling window 302a and a second sampling window 302b arranged radially-opposite the first sampling window 302a on the flow path 204.The first and second sampling windows 302a,b may be similar to the sampling window 216 described above in FIG.", "2 and therefore will not be described again.", "As the electromagnetic radiation 210 passes through the fluid 202 via the first and second sampling windows 302a,b, it optically interacts with the fluid 202 and optically interacted radiation 218 is subsequently directed to or otherwise received by the ICE 220 as arranged within the device 300.It is again noted that, while FIG.", "3 depicts the ICE 220 as receiving the optically interacted radiation 218 as transmitted through the sampling windows 302a,b, the ICE 220 may equally be arranged at any point along the optical train of the device 300, without departing from the scope of the disclosure.", "For example, in one or more embodiments, the ICE 220 may be arranged within the optical train prior to the first sampling window 302a and equally obtain substantially the same results.", "In yet other embodiments, the ICE 220 may generate the modified electromagnetic radiation 222 through reflection, instead of transmission therethrough.", "Moreover, as with the device 200 of FIG.", "2, embodiments are contemplated herein which include the use of at least two ICE components in the device 300 configured to cooperatively determine the characteristic of interest in the fluid 202.The modified electromagnetic radiation 222 generated by the ICE 220 is subsequently conveyed to the detector 224 for quantification of the signal and generation of the output signal 226 which corresponds to the particular characteristic of interest in the fluid 202.The device 300 may also include the second detector 228 for detecting radiating deviations stemming from the electromagnetic radiation source 208.As illustrated, the second detector 228 may be configured to receive a portion of the optically interacted radiation 218 via the beamsplitter 232 in order to detect the radiating deviations.", "The output signal 226 and the compensating signal 230 may then be conveyed to or otherwise received by the signal processor 234 which may computationally combine the two signals 230, 226 and provide in real-time or near real-time the resulting output signal 236 corresponding to the concentration of the characteristic of interest in the fluid 202.Those skilled in the art will readily appreciate the various and numerous applications that the optical computing devices 200, 300, and various alternative configurations thereof, may be suitably used with.", "The systems and methods described herein utilize at least one optical computing device in combination with at least one gas analysis device to more accurately measure the gas composition in the drilling fluid at various points in a drilling fluid circulation system.", "The gas analysis devices measure the concentrations of all the gases of interest in the gas extracted from the drilling fluid, and the optical computing devices measure the concentration of only some of the gases of interest.", "A correction factor can be derived from a comparison of the measurements of the two types of devices.", "Depending on the configuration of the system, the correction factor can be a single point correction factor, a dual point correction factor, or a point-to-point correction factor.", "FIG.", "4 provides an illustrative representation of a portion of a system 400 suitable for deriving a single point correction factor for the gas composition of a fluid.", "The fluid flows into a degasser 410 through feed line 412.The degasser 410 extracts at least a portion of the gas entrained in the fluid.", "At least a portion of the extracted gas may then be transferred to at least one gas analysis device 414 via feed line 416.The gas analysis devices 414 may analyze the composition of the extracted gas for the concentration of gases of interest and the amount of total gas.", "At least one optical computing device 418 may be arranged in the system 400 before the degasser 410 and be configured to measure the concentration of a reference compound and a gas from the formation (e.g., methane or ethane).", "The reference compound may be a volatile compound that is introduced into the fluid (e.g., fluorinated hydrocarbons), indigenous to the fluid (e.g., CO2), or a spectral overlapping gas (e.g., ethane that overlaps with methane or ethane that overlaps ethane).", "Each of the gas analysis devices 414 and optical computing devices 418 may produce output signals 420,422, respectively, corresponding to the measurements taken.", "The output signals 420,422 are received by a signal processor 424 communicably coupled to the gas analysis devices 414 and optical computing devices 418.The signal processor 424 may be similar to the signal processor 234 of FIGS.", "2 and 3 and may be configured to receive and process the output signals 420,422.In particular, the signal processor 424 may employ an algorithm configured to calculate or otherwise determine the concentration of the gases detected by the gas analysis devices 414, calculate a correction factor, apply the correction factor to the output signals 422 of the optical computing devices 418 to calculate the concentration of the gas detected by the optical computing devices 418, and extrapolate the concentration of all the gases of interest in the drilling fluid.", "For example, the optical computing devices 418 may be configured to measure the concentration of methane in the drilling fluid (“[CH4]DF”) and the concentration of the reference compound in the drilling fluid (“[ref]DF”).", "The gas analysis devices 414 may be configured to measure the concentration of methane in the extracted gas (“[CH4]EG”), the concentration of the reference compound in the extracted gas (“[ref]EG”), and the concentration of one or more other gases of interest in the extracted gas (“[gas]EG”).", "A single point correction factor can be determined by comparing [CH4]DF/[CH4]EG and [ref]DF/[ref]EG or variations in [CH4]DF/[CH4]EG and [ref]DF/[ref]EG.", "The comparison of the concentrations in the drilling fluid and extracted gas may include sums or other methods to account for interaction factors from other compounds.", "When the spectral response of the reference gas has peaks within a spectral response of an overlapping gas, peak fittings can be used to determine overlap at the point of measurement.", "The intensity of overlap then be removed before determining the correction factor.", "After the correction factor has been determined, curve fitting can be used to apply the correction factor to each of the [gas]EG and extrapolate the concentration of all the gases of interest in the drilling fluid.", "FIG.", "5 provides an illustrative representation of a portion of a system 500 suitable for deriving a dual point correction factor for the gas composition of a fluid.", "The fluid flows into a degasser 510 through feed line 512.The degasser 510 extracts at least a portion of the gas entrained in the fluid.", "At least a portion of the extracted gas may then be transferred to at least one gas analysis device 514 via feed line 516.The gas analysis devices 514 may analyze the composition of the extracted gas for the concentration of gases of interest and the amount of total gas.", "At least one optical computing device 518 may be arranged in the system 500 before the degasser 510 and be configured to measure the concentration of a reference compound and a gas from the formation.", "At least one optical computing device 520 may be arranged in the system 500 between the degasser 510 and the gas analysis devices 514 and be configured to measure the concentration of the reference compound and the gas from the formation.", "Each of the gas analysis devices 514 and optical computing devices 518,520 may produce output signals 522,524,526, respectively, corresponding to the measurements taken.", "The output signals 522,524,526 are received by a signal processor 528 communicably coupled to the gas analysis devices 514 and optical computing devices 518,520.A dual point calibration may advantageously be able to correct for a non-linear background in measurements, which may be contributed to by a compound with an overlapping spectrum.", "In some instances, the foregoing calibration methods may utilize more than one reference compound.", "In some instances, no reference gas may be used by developing a direct relationship between and calibration curve for the measurements of the optical computing devices and the gas analysis devices, which may be referred to herein as a point-to-point calibration.", "In any of the foregoing calibration arrangements and methods, the calibration may be performed continuously in some embodiments.", "Alternatively, in some instance, the calibration may be performed periodically (e.g., once every 15 minutes, once every hour, etc.).", "Additionally, the calibration may, in some instance, be performed on-demand (e.g., as triggered by an operator).", "This further contributes to the accuracy of the systems and methods described herein for measuring gas content and gas composition in a drilling fluid in real-time.", "In the illustrated examples of the calibrations, the optical computing devices are deployed proximal to the degasser.", "However, additional optical computing devices can be deployed at various points within a drilling fluid circulation system to monitor the drilling fluid and its associated gas content using the calibrations for each type of optical computing device being determined with one of the above or similar systems/methods.", "Depending on the location of the particular optical computing device, different types of information about the fluid can be obtained.", "In some cases, for example, the optical computing devices can be used to monitor the type and concentration of gases therein before and after the drilling fluid circulates into and out of a wellbore.", "In other cases, the optical computing devices may be used to analyze an extracted gas sample in real-time following its extraction from the drilling fluid via a traditional drilling fluid sampling process.", "In other cases, the optical computing devices may be used to monitor the drilling fluid at or near a wellbore choking device so as to register real-time gas concentrations of the drilling fluid while the drilling fluid circulates at wellbore conditions.", "For example, referring now to FIG.", "6, illustrated is an exemplary wellbore drilling assembly 600 that may employ one or more optical computing devices as described herein in order to monitor a drilling fluid or a completion fluid, according to one or more embodiments.", "The drilling assembly 600 may include a drilling platform 602 that supports a derrick 604 having a traveling block 606 for raising and lowering a drill string 608.A kelly 610 supports the drill string 608 as it is lowered through a rotary table 612.A drill bit 614 is attached to the distal end of the drill string 608 and is driven either by a downhole motor and/or via rotation of the drill string 608 from the well surface.", "As the bit 614 rotates, it creates a borehole 616 that penetrates various subterranean formations 618.A pump 620 (e.g., a mud pump) circulates drilling fluid 622 through a feed pipe 624 and to the kelly 610, which conveys the drilling fluid 622 downhole through an interior conduit defined in the drill string 608 and through one or more orifices in the drill bit 614.The drilling fluid 622 is then circulated back to the surface via an annulus 626 defined between the drill string 608 and the walls of the borehole 616.The drilling fluid 622 provides hydrostatic pressure to prevent formation fluids from entering into the borehole 616 and keeps the drill bit 614 cool and clean during drilling.", "The drilling fluid 622 also serves to carry drill cuttings and solids out of the borehole 616 and suspend the drill cuttings and solids while drilling is paused and/or when the drill bit 614 is brought in and out of the borehole 616.As the spent drilling fluid 622 returns to the surface, it may exit the annulus 626 at the wellhead 627 and subsequently pass through one or more chokes or choke valves 628 (one shown) via an interconnecting flow line 630.The choke valve 628 may be used to maintain or otherwise regulate the pressure on the annulus 626 at surface, for example in the range of about 100 psi to about 1500 psi.", "As a result, this will enable drilling to continue underbalanced and is useful in reducing formation damage, but also to facilitate increases in drilling speed.", "It will be appreciated, however, that the choke valve(s) 628 may be omitted in other embodiments and the spent drilling fluid 622 may instead return to the surface at atmospheric pressures, without departing from the scope of the disclosure.", "Following the choke valve 628, the spent drilling fluid 622 may be conveyed to one or more drilling fluid rehabilitation devices via the interconnecting flow line 630.Such drilling fluid rehabilitation devices may include, but are not limited to, one or more degassing units 632 and solids control equipment 634 (e.g., shakers).", "The degassing unit 632 may be any device or machine configured to separate from the drilling fluid 622 gases (i.e., hydrocarbon and non-hydrocarbon gas species) that may have been entrained in the drilling fluid 622 while circulating in and out of the borehole 616.The solids control equipment 634 may be configured to substantially remove the drill cuttings and solids from the drilling fluid 622 and deposit a “cleaned” drilling fluid 622 into a nearby retention pit 636 (i.e., a mud pit).", "Several additives or components may be added to the drilling fluid 622 in order to maintain the drilling fluid 622 in proper working order and otherwise enhance drilling capabilities.", "In some embodiments, the additives and components may be added to the drilling fluid 622 via a mixing hopper 638 fluidly coupled to the retention pit 636.Exemplary components that may be added to the drilling fluid 622 include, but are not limited to, emulsions, weighting materials, viscosifiers, thickeners, rheology modifiers, thinners, deflocculants, anionic polyelectrolytes (e.g., acrylates, polyphosphates, lignosulfonates, tannic acid derivates, etc.", "), high-heat polymers, clay stabilizers, clay inhibitors, tar treatments, water and other base fluids, combinations thereof, and the like.", "The rehabilitated drilling fluid 622 may then be recirculated and pumped back into the borehole 616 with the pump 620 via the feed pipe 624.According to the present disclosure, mud logging gas analysis of the drilling fluid 622 may be undertaken using optical computing devices 640 and gas analysis devices 650 with calibrations of the optical computing devices 640 according to the methods and configurations described relative to FIGS.", "4-5 or similar thereto.", "The gas analysis device 650 received gas from the degassing unit 632 through flow line 652.Depending on the analysis method, optical computing devices may be arranged in various locations throughout the circulation system of the drilling assembly 600.For example, as shown in FIG.", "6, optical computing devices 640a, 640b, 640c, 640d, and 640e may be arranged along flow pipe 624, along flow line 630 between the choke valve 628 and the degassing unit 632, along flow line 630 before choke valve 628, along the flow line 652 between the degassing unit 632 and the gas analysis devices 650, and along flow line 630 between the degassing unit 632 and the solids control equipment 634, respectively.", "The optical computing devices 640a-e may be substantially similar to at least one of the optical computing devices 200, 300 of FIGS.", "2 and 3, respectively, and therefore will not be described again in detail.", "In exemplary operation, the optical computing devices 640a-e may be configured to measure and report real-time characteristics of the drilling fluid 622, such as the type and/or concentration of one or more gases present therein at their respective monitoring locations.", "In one or more embodiments, the optical computing devices 640a-e may be communicably coupled to a signal processor 642 and configured to convey corresponding output signals 644a-e, respectively, to the signal processor 642.The signal processor 642 may be similar to the signal processor 234 of FIGS.", "2 and 3 and may be configured to receive and process the output signals 644a-e.", "In particular, the signal processor 642 may employ an algorithm configured to calculate or otherwise determine the concentration or type of a gas detected at each monitoring location.", "The signal processor 642 may further be configured to determine the differences between any two or more of the output signals 640a-e.", "In other words, the signal processor 642 may be configured to determine how the concentration of the gas and/or the magnitude of the characteristic of interest in the fluid 622 changed between each monitoring location.", "Further, the signal processor 642 may be configured receive output signals 654 from the gas analysis devices 650, so as to perform a comparative analysis between the gas concentrations measured by the gas analysis devices 650 and individual optical computing devices 640a-e (described further herein).", "In real-time or near real-time, the signal processor 642 may be configured to provide a resulting output signal 646 corresponding to the concentration of individual gases or the total gas, each of which may be measured or derived as described further herein.", "In some embodiments, the resulting output signal 646 may be conveyed, either wired or wirelessly, to one or more peripheral devices 648 communicably coupled to the signal processor 642.The peripheral devices 648 may include, but are not limited to, a mobile device, computer monitor, or a printer coupled to a computer.", "In some embodiments, the peripheral devices 648 may be configured to provide one or more graphical outputs such as a Pixler plot, a Haworth Plot, or a gas-ratio plot, depicting various properties, parameters, and characteristic(s) detected in the fluid 622 (e.g., the concentration of individual gases or the total gas in the drilling fluid).", "A well operator may then be able to consult and interpret the graphical output and thereby make intelligent decisions on how best to manage the well in response thereto.", "In other embodiments, the peripheral devices 648 may include an audible or visual alarm mechanism or device that may be triggered.", "For example, the one or more of the output signals 644a-e, 654 or an analysis thereof may be recognized by the signal processor 642 as being within or without a predetermined or preprogrammed range of suitable operation for the drilling fluid 622.If the output signals 644a-e, 654 or an analysis thereof exceed the predetermined or preprogrammed range of operation, the resulting output signal 646 may trigger an alarm forming part of the peripheral device 648 and the alarm may be configured to alert the operator so appropriate corrective action may be taken on the drilling fluid 622.In some embodiments, the signal processor 642 may be configured to autonomously undertake the appropriate corrective action such that the resulting output signal 646 returns to a value within the predetermined or preprogrammed range of suitable operation.", "For example, the signal processor 642 may be communicably coupled to an automated control system (not shown) that may be configured to undertake the required corrective action.", "As illustrated, optical computing device 640b and gas analysis device 650 may be configured and operate similar to that of optical computing device 418 and gas analysis device 415 of FIG.", "4 to provide a single-point calibration that may be applied to other optical computing devices arranged in the system 600.Further, optical computing devices 640b,640d and gas analysis device 650 may be configured and operate similar to that of optical computing devices 518,520 and gas analysis device 514 of FIG.", "5 to provide a dual-point calibration that may be applied to other optical computing devices arranged in the system 600.In some embodiments, gas concentration measured from the optical computing device 640e arranged along the flow line 630 after the degasser 632 may be compared to the gas concentration from the optical computing device 640b arranged before the degasser to provide a degassing efficiency.", "In some embodiments, a first optical computing device 640a may be arranged to monitor the drilling fluid 622 as it is being introduced into the borehole 616 and a second optical computing device 640b may be arranged to monitor the drilling fluid 622 after it has returned to the surface and is otherwise de-pressurized via the choke valve 628.More particularly, the first optical computing device 640a may be arranged in the feed pipe 624 leading to the derrick 604 from the pump 620 (or otherwise at any fluidly communicable location following the pump 620 and before the borehole 616), and the second optical computing device 640b may be arranged on or otherwise coupled to the flow line 630 before the degassing unit 632 (e.g., adjacent an inlet to the degassing unit 632).", "As will be appreciated, more than one optical computing device may be arranged at each of these monitoring locations, without departing from the scope of the disclosure.", "The first output signal 644a may be indicative of the type/concentration of a gas in the drilling fluid 622 or another characteristic of the fluid 622 as the drilling fluid 622 enters the borehole 616.Likewise, the second output signal 644b may be indicative of the type/concentration of the gas or another characteristic of the fluid 622 as the drilling fluid 622 exits the borehole 616 de-pressurized.", "The signal processor 642 may receive the output signals 644a,b in real-time and provide the resulting output signal 646 that may be considered by an operator via the one or more peripheral devices 648, as described above.", "In some embodiments, the resulting output signal 646 may inform the operator of the type/concentration of gas in the drilling fluid 622 as the drilling fluid 622 enters the borehole 616, as per the first output signal 644a.", "In other embodiments, the resulting output signal 646 may inform the operator of the type/concentration of the gas in the drilling fluid 622 as the drilling fluid 622 exits the borehole 616, as per the second output signal 644b.", "As a result, the operator may be able to conduct mud logging gas analyses of the drilling fluid 622 without having to extract a gas sample from the returning drilling fluid 622.In yet other embodiments, the signal processor 642 may be configured to make a comparison between the first and second output signals 644a,b, and thereby provide the operator with a resulting output signal 646 via the peripheral devices 648 that details the differences between the two output signals 644a,b.", "As such, the operator may be apprised as to the quantity and concentration of one or more gases that may have entered or otherwise become entrained in the drilling fluid 622 while circulating through the borehole 616.Such data may be useful in providing information as to the hydrocarbon content of the rock being drilled through and, as a result, the operator may decide to adjust one or more drilling or completion parameters in response thereto.", "For example, in some embodiments, the resulting output signal 646 may inform the operator that a particular type or quantity of favorable gas is found in a particular strata or region of the subterranean formation 618 while drilling.", "As a result, at least one drilling parameter may be adjusted in response thereto, such as altering the geosteering of the drill bit 614 so that the borehole 616 may be drilled or formed substantially in that strata or zone.", "In some embodiments, the favorable gas may be one or more hydrocarbons that may be produced for processing.", "In other embodiments, however, the favorable gas may be helium.", "Those skilled in the art will readily recognize that an increased amount of helium returning to the surface as entrained in the drilling fluid 622 may be an indication of high porosity in the formation 618, and high porosity can signify a zone capable of increased production rates.", "When such gases and hydrocarbons are detected, the operator may alter the geosteering well path such that the borehole remains substantially in that stratum, thereby maximizing potential hydrocarbon production and efficiencies.", "As will be appreciated, this may prove especially advantageous in deviated or horizontal wells where altering the geosteering may have the effect of maintaining the well path substantially parallel and otherwise within a hydrocarbon-bearing stratum or region.", "This may also prove advantageous, however, in vertical wells where the well operator may be able to log the area of the vertical borehole 616 where a high gas content is detected.", "At a later time, the operator may choose to return to that location and complete the borehole 616 at that location such that the hydrocarbons residing in the formation 618 at that location may be effectively produced with greater efficiency.", "Accordingly, the well completion design may be optimized in response to resulting output signal 646 and what is provided via the peripheral devices 648.Some well completion designs that may be altered include, but are not limited to, changing a cementing program, changing a casing program or design, or optimizing placement of downhole perforations, sliding sleeves, and slotted liners.", "Optimizations resulting from such well completion alterations may include containment of unwanted fluids downhole, such as water or unwanted gas, and may also include optimizing isolation of zones from which production is not required.", "Further, nearby wells having similar (correlated) output signals 644a-c or output signal 646 may implement similar optimizations.", "In some embodiments, the resulting output signal 646 may also be configured to inform an operator via the peripheral devices 648 of hazardous, corrosive, or otherwise toxic gases that may be entrained in the drilling fluid 622.Hazardous, corrosive, and/or toxic gases, such as hydrogen sulfide (H2S) and the like, may pose a danger to rig operators and the surrounding environment.", "In at least one embodiment, for example, the second output signal 644b of the second optical computing device 640b may provide the real-time concentration of hydrogen sulfide (H2S) entrained in the drilling fluid 622 as it returns to the surface.", "If the registered level of H2S surpasses a predetermined “safe” limit, the signal processor 642 may be configured to trigger an alarm by sending the resulting output signal 646 to the peripheral devices 648 indicating the same.", "In response to the alarm, the operator may act by shutting down the well or adding H2S scavengers or other additives to the drilling fluid 622 via the hopper 638 to remedy the situation.", "In some embodiments, the hazardous, corrosive, or otherwise toxic gas may be methane as entrained in the drilling fluid 622.Since methane is highly explosive, increased amounts of the gas in the returning drilling fluid 622 may pose a substantial risk to rig operators and the surrounding environment.", "Accordingly, if there is an excessive amount of methane being detected by, for example, the second optical computing device 640b, such that it surpasses a predetermined “safe” limit, the signal processor 642 may be configured to trigger an alarm via the resulting output signal 646 and the peripheral devices 648.In response to the alarm, the operator may act to remedy the situation.", "For example, the operator may “shut in” the well using blow-out preventers or the like and then extract the methane in a controlled manner using choke and kill lines associated with the blow-out preventers.", "In some embodiments, the drilling fluid 622 returned to the surface may be monitored using the third optical computing device 640c prior to full de-pressurization.", "As illustrated, the third optical computing device 640c may be arranged in fluid communication with the interconnecting flow line 630 following the wellhead 627 and otherwise arranged prior to the choke valve 628.Similar to the second optical computing device 640b, the third optical computing device 640c may be configured to monitor the drilling fluid 622 after its return to the surface for gases (both hydrocarbon and non-hydrocarbon gas species) that may have become entrained therein after having circulated through the borehole 616.When the drilling fluid 622 exits the choke valve 628, any gases entrained therein will immediately break out or otherwise precipitate out of the drilling fluid 622.Accordingly, the third optical computing device 640c may be advantageous in providing a real or near real-time concentration of one or more gases in the drilling fluid 622 as it circulates at or near actual downhole drilling environment conditions.", "The output signal 644c from the third optical computing device 640c, therefore, may be useful in mud logging gas analysis of the drilling fluid 622 at downhole operating conditions.", "Similar to the second optical computing device 640b, the third optical computing device 640c may be configured to detect and report increased amounts of a favorable gas in the borehole 616.The resulting output signal 646 may then inform the operator where a particular type or quantity of favorable gas is found in the borehole 616 and, as a result, at least one drilling parameter may be adjusted in response thereto.", "For example, the operator may alter the geosteering of the drill bit 614 so that the borehole 616 may be drilled or formed substantially in that stratum or zone.", "In vertical boreholes 616, the well operator may be able to log the area of the borehole 616 where a high gas content is detected and, at a later time, return to that location and complete the borehole 616 at that location such that the hydrocarbons residing in the formation 618 at that location may be effectively produced with greater efficiency.", "The third optical computing device 640c may also be configured to detect hazardous, corrosive, or otherwise toxic gases (i.e., H2S, methane, etc.)", "that may be entrained in the drilling fluid 622.The resulting output signal 646 in such cases may inform an operator via the peripheral devices 648 of the presence of such gases, and the operator may then act to remedy the situation.", "In other embodiments, the signal processor 642 may autonomously act to remedy the situation, such as by shutting down the well or adding H2S scavengers or other additives to the drilling fluid 622 via the hopper 638 to remedy the situation.", "For example, as briefly mentioned above, the signal processor 642 may be communicably coupled to an automated control system (not shown) that may be configured to undertake the required corrective action.", "It is recognized that the various embodiments herein directed to computer control and artificial neural networks, including various blocks, modules, elements, components, methods, and algorithms, can be implemented using computer hardware, software, combinations thereof, and the like.", "To illustrate this interchangeability of hardware and software, various illustrative blocks, modules, elements, components, methods and algorithms have been described generally in terms of their functionality.", "Whether such functionality is implemented as hardware or software will depend upon the particular application and any imposed design constraints.", "For at least this reason, it is to be recognized that one of ordinary skill in the art can implement the described functionality in a variety of ways for a particular application.", "Further, various components and blocks can be arranged in a different order or partitioned differently, for example, without departing from the scope of the embodiments expressly described.", "Computer hardware used to implement the various illustrative blocks, modules, elements, components, methods, and algorithms described herein can include a processor configured to execute one or more sequences of instructions, programming stances, or code stored on a non-transitory, computer-readable medium.", "The processor can be, for example, a general purpose microprocessor, a microcontroller, a digital signal processor, an application specific integrated circuit, a field programmable gate array, a programmable logic device, a controller, a state machine, a gated logic, discrete hardware components, an artificial neural network, or any like suitable entity that can perform calculations or other manipulations of data.", "In some embodiments, computer hardware can further include elements such as, for example, a memory (e.g., random access memory (RAM), flash memory, read only memory (ROM), programmable read only memory (PROM), erasable read only memory (EPROM)), registers, hard disks, removable disks, CD-ROMS, DVDs, or any other like suitable storage device or medium.", "Executable sequences described herein can be implemented with one or more sequences of code contained in a memory.", "In some embodiments, such code can be read into the memory from another machine-readable medium.", "Execution of the sequences of instructions contained in the memory can cause a processor to perform the process steps described herein.", "One or more processors in a multi-processing arrangement can also be employed to execute instruction sequences in the memory.", "In addition, hard-wired circuitry can be used in place of or in combination with software instructions to implement various embodiments described herein.", "Thus, the present embodiments are not limited to any specific combination of hardware and/or software.", "As used herein, a machine-readable medium will refer to any medium that directly or indirectly provides instructions to a processor for execution.", "A machine-readable medium can take on many forms including, for example, non-volatile media, volatile media, and transmission media.", "Non-volatile media can include, for example, optical and magnetic disks.", "Volatile media can include, for example, dynamic memory.", "Transmission media can include, for example, coaxial cables, wire, fiber optics, and wires that form a bus.", "Common forms of machine-readable media can include, for example, floppy disks, flexible disks, hard disks, magnetic tapes, other like magnetic media, CD-ROMs, DVDs, other like optical media, punch cards, paper tapes and like physical media with patterned holes, RAM, ROM, PROM, EPROM and flash EPROM.", "It should also be noted that the various drawings provided herein are not necessarily drawn to scale nor are they, strictly speaking, depicted as optically correct as understood by those skilled in optics.", "Instead, the drawings are merely illustrative in nature and used generally herein in order to supplement understanding of the systems and methods provided herein.", "Indeed, while the drawings may not be optically accurate, the conceptual interpretations depicted therein accurately reflect the exemplary nature of the various embodiments disclosed.", "Embodiments disclosed herein include Embodiment A, Embodiment B, and Embodiment C. Embodiment A A system that includes: a flow path circulating a drilling fluid into and out of a borehole penetrating a subterranean formation during a drilling operation, wherein the flow path includes a degasser that includes a drilling fluid inlet, a drilling fluid outlet, and a gas outlet, and wherein the gas outlet is fluidly coupled to a gas analysis device configured to produce a first output signal, a second output signal, and a third output signal corresponding to a concentration of a first gas, a second gas, and a third gas, respectively; a first integrated computational element and a second integrated computational element arranged along the flow path prior to the drilling fluid inlet of the degasser and configured to optically interact with the drilling fluid and generate a fourth output signal and a fifth output signal, respectively, corresponding to a concentration of the first gas present in the drilling fluid and a concentration of the second gas present in the drilling fluid, respectively; a signal processor communicably coupled to the first integrated computational element, the second integrated computational element, and the gas analysis device, wherein the signal processor is configured to (1) receive the first output signal, the second output signal, the third output signal, the fourth output signal, and the fifth output signal, (2) calculate a calibration factor based on an analysis of the first output signal relative to the fourth output signal and the second output signal relative to the fifth output signal, and (3) apply the calibration factor to the third output signal to produce a calibrated output signal corresponding to a calibrated concentration of the third gas.", "Embodiment A may have one or more of the following additional elements in any combination: Element A1: the system further including a third integrated computational element and a fourth integrated computational element arranged between the gas outlet of the degasser and the gas analysis device and configured to (1) optically interact with a gas composition extracted from the drilling fluid by the degasser and (2) generate a sixth output signal and a seventh output signal, respectively, corresponding to a concentration of the first gas present in the gas composition and a concentration of the second gas present in the gas composition, respectively; and wherein the signal processor is configured to (1) receive the sixth output signal and the seventh output signal and (2) further calculate the calibration factor based on an analysis of the first output signal relative to the fourth and sixth output signals and the second output signal relative to the fifth and seventh output signals; Element A2: the system further including one or more peripheral devices communicably coupled to the signal processor and configured to receive the calibrated output signal from the signal processor and report the calibrated concentration of the third gas to a well operator; Element A3: Element A2 wherein the one or more peripheral devices are further configured to adjust one or more parameters of the drilling operation in response to the calibrated concentration of the third gas; Element A4: wherein at least one of the first gas and the second gas is not from the subterranean formation; Element A5: wherein the first gas and the second gas are from the subterranean formation; Element A6: wherein the first gas or the second gas is methane; and Element A7: wherein the first gas or the second gas is carbon dioxide.", "By way of non-limiting example, exemplary combinations applicable to Embodiment A include: Element A5 in combination with Element A6 and optionally Element A7, Element A5 in combination with Element A7, Element A4 in combination with Element A7, at least one of Elements A1-A3 in combination with any of the foregoing, and Element A1 in combination with Element A2 and optionally Element A3.Embodiment B A method that includes: circulating a drilling fluid within a flow path that extends into and out of a borehole penetrating a subterranean formation during drilling operations and includes a degasser having a drilling fluid inlet, a drilling fluid outlet, and a gas outlet; generating a first output signal, a second output signal, and a third output signal corresponding to a concentration of a first gas, a second gas, and a third gas with a gas analysis device fluidly coupled to the gas outlet of the degasser; generating a fourth output signal with a first integrated computational element and a fifth output signal with a second integrated computational element arranged along the flow path prior to the drilling fluid inlet of the degasser corresponding to a concentration of the first gas present in the drilling fluid and a concentration of the second gas present in the drilling fluid, respectively; receiving the first output signal, the second output signal, the third output signal, the fourth output signal, and the fifth output signal with a signal processor communicably coupled to the gas analysis device, the first optical computing device, and the second optical computing device; calculating a calibration factor based on an analysis of the first output signal relative to the fourth output signal and the second output signal relative to the fifth output signal; and applying the calibration factor to the third output signal to produce a calibrated output signal corresponding to a calibrated concentration of the third gas.", "Embodiment B may have one or more of the following additional elements in any combination: Element B1: the method further including generating a sixth output signal with a third integrated computational element and a seventh output signal with a fourth integrated computational element arranged between the gas outlet of the degasser and the gas analysis device corresponding to a concentration of the first gas present in a gas composition extracted from the drilling fluid by the degasser and a concentration of the second gas present in the gas composition, respectively; receiving the sixth output signal and the seventh output signal with the signal processor communicably coupled to the third optical computing device and the fourth optical computing device; and further calculating the calibration factor based on an analysis of the first output signal relative to the fourth and sixth output signals and the second output signal relative to the fifth and seventh output signals; Element B2: the method including Element B1 and further including conveying the calibrated output signal to one or more peripheral devices; and adjusting one or more drilling or completion parameters in response to the calibrated concentration of the third gas; Element B3: wherein at least one of the first gas and the second gas is not from the subterranean formation; Element B4: wherein the first gas and the second gas are from the subterranean formation; Element B5: wherein the first gas or the second gas is methane; Element B6: wherein the first gas or the second gas is carbon dioxide; Element B7: the method further including conveying the calibrated output signal to one or more peripheral devices; and adjusting one or more drilling or completion parameters in response to the calibrated concentration of the third gas; Element B8: Element B7 wherein adjusting the one or more drilling or completion parameters comprises altering the geosteering of a drill bit; and Element B9: Element B7 wherein adjusting the one or more drilling or completion parameters comprises at least one of changing a cementing program, changing a casing program, changing a casing design, optimizing placement of downhole perforations, sliding sleeves, and slotted liners, and optimizing isolation of zones from which production is not required.", "By way of non-limiting example, exemplary combinations applicable to Embodiment B include: Element B4 in combination with Element B5 and optionally Element B6, Element B4 in combination with Element B6, Element B3 in combination with Element B6, at least one of Elements B3-B6 in combination with at least one of Elements B7-B9, at least one of Elements B3-B6 in combination with at least one of Elements B1-B2, Element B1 in combination with Element B2; and Element B1 in combination with Element B7 and optionally at least one of Elements B8-B9.Embodiment C A method that includes: circulating a drilling fluid within a flow path that extends into and out of a borehole penetrating a subterranean formation during a drilling operation and includes a degasser having a drilling fluid inlet, a drilling fluid outlet, and a gas outlet; generating a first output signal, a second output signal, and a third output signal corresponding to a concentration of a first gas, a second gas, and a third gas with a gas analysis device fluidly coupled to the gas outlet of the degasser; generating a fourth output signal with a first integrated computational element and a fifth output signal with a second integrated computational element arranged along the flow path prior to the drilling fluid inlet of the degasser corresponding to a concentration of the first gas present in the drilling fluid and a concentration of a fourth gas present in the drilling fluid, respectively; receiving the first output signal, the second output signal, the third output signal, the fourth output signal, and the fifth output signal with a signal processor communicably coupled to the gas analysis device, the first optical computing device, and the second optical computing device; calculating a calibration factor based on an analysis of the first output signal relative to the fourth output signal and the second output signal relative to the fifth output signal; and applying the calibration factor to the third output signal to produce a calibrated output signal corresponding to a calibrated concentration of the third gas.", "Embodiment C may have one or more of the following additional elements in any combination: Element C1: wherein at least one of the first gas and the second gas is not from the subterranean formation; Element C2: wherein the first gas and the second gas are from the subterranean formation; Element C3: wherein the first gas or the second gas is methane; Element C4: wherein the first gas or the second gas is carbon dioxide; and Element C5: the method further including conveying the calibrated output signal to one or more peripheral devices.", "By way of non-limiting example, exemplary combinations applicable to Embodiment C include: Element C2 in combination with Element C3 and optionally Element C4, Element C2 in combination with Element C4, Element C2 in combination with Element C4, and at least one of Elements C1-C4 in combination with Element C5.Therefore, the present disclosure is well adapted to attain the ends and advantages mentioned as well as those that are inherent therein.", "The particular embodiments disclosed above are illustrative only, as the present disclosure may be modified and practiced in different but equivalent manners apparent to those skilled in the art having the benefit of the teachings herein.", "Furthermore, no limitations are intended to the details of construction or design herein shown, other than as described in the claims below.", "It is therefore evident that the particular illustrative embodiments disclosed above may be altered, combined, or modified and all such variations are considered within the scope and spirit of the present disclosure.", "The disclosure illustratively described herein suitably may be practiced in the absence of any element that is not specifically disclosed herein and/or any optional element disclosed herein.", "While compositions and methods are described in terms of “comprising,” “containing,” or “including” various components or steps, the compositions and methods can also “consist essentially of” or “consist of” the various components and steps.", "All numbers and ranges disclosed above may vary by some amount.", "Whenever a numerical range with a lower limit and an upper limit is disclosed, any number and any included range falling within the range is specifically disclosed.", "In particular, every range of values (of the form, “from about a to about b,” or, equivalently, “from approximately a to b,” or, equivalently, “from approximately a-b”) disclosed herein is to be understood to set forth every number and range encompassed within the broader range of values.", "Also, the terms in the claims have their plain, ordinary meaning unless otherwise explicitly and clearly defined by the patentee.", "Moreover, the indefinite articles “a” or “an,” as used in the claims, are defined herein to mean one or more than one of the element that it introduces." ] ]
Patent_15876022
[ [ "SELECTIVE ADHERENCE OF STENT-GRAFT COVERINGS", "An endoluminal prosthesis including a radially expandable support member having interior and exterior surfaces and a wall with openings, a first covering member including a biocompatible polymer material at least partially positioned against the interior surface, and a second covering member including a biocompatible polymer material at least partially positioned against the exterior surface.", "The first covering member attaches to the second covering member at predetermined bonding locations within less than all of the openings thereby leaving unbonded regions." ], [ "1.A prosthesis comprising: an expandable support comprising plural openings; a first covering inside of the support; and a second covering outside of the support, wherein the first and second coverings have multiple connections that extend through openings in the support and the connections form a pattern of loose space around the support.", "2.The prosthesis of claim 1 wherein the pattern of loose space includes a pocket around the support.", "3.The prosthesis of claim 2 wherein the prosthesis further comprises a therapeutic agent.", "4.The prosthesis of claim 3 wherein the pocket holds the therapeutic agent.", "5.The prosthesis of claim 4 wherein the connections additionally form a predominantly circumferential pattern.", "6.The prosthesis of claim 5 wherein the first covering is biocompatible.", "7.The prosthesis of claim 6 wherein the second covering is biocompatible.", "8.The prosthesis of claim 7 wherein the support and the first covering are unconnected.", "9.The prosthesis of claim 4 wherein the connections additionally form a predominantly longitudinal pattern.", "10.The prosthesis of claim 9 wherein the prosthesis length is greater than the first covering length and the second covering length.", "11.The prosthesis of claim 10 wherein the first covering and the second covering are fully bonded at their ends.", "12.The prosthesis of claim 11 wherein the second covering is biocompatible.", "13.The prosthesis of claim 12 wherein the first covering is biocompatible.", "14.The prosthesis of claim 13 wherein the support and the second covering are unconnected.", "15.The prosthesis of claim 14 wherein the support is radially expandable.", "16.The prosthesis of claim 15 wherein the support is cylindrical.", "17.The prosthesis of claim 16 wherein the support is a stent.", "18.A prosthesis comprising: a radially expandable stent comprising a plurality of openings; a first biocompatible covering inside of the stent; and a second biocompatible outside of the stent, wherein the first and second coverings are fully bonded at their ends, are unconnected to the stent, and have multiple connections that extend through openings in the stent, and the connections form a pattern of loose space defining a pocket around the stent, the pocket contains a therapeutic agent, and the stent length is greater than the first covering length and the second covering length." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>The use of implantable vascular grafts comprised of PTFE is well known in the art.", "These grafts are typically used to replace or repair damaged or occluded blood vessels within the body.", "However, if such grafts are radially expanded within a blood vessel, they will exhibit some subsequent retraction.", "Further, such grafts usually require additional means for anchoring the graft within the blood vessel, such as sutures, clamps, or similarly functioning elements.", "To minimize the retraction and eliminate the requirement for additional attachment means, those skilled in the art have used stents, such as those presented by Palmaz in U.S. Pat.", "No.", "4,733,665 and Gianturco in U.S. Pat.", "No.", "4,580,568, which are incorporated by reference into this application as if fully set forth herein, either alone or in combination with PTFE grafts.", "For example, the stent described by Palmaz in U.S. Pat.", "No.", "4,733,665 can be used to repair an occluded blood vessel.", "The stent is introduced into the blood vessel via a balloon catheter, which is then positioned at the occluded site of the blood vessel.", "The balloon is then expanded, thereby expanding the overlying stent to a diameter comparable to the diameter of an unoccluded blood vessel.", "The balloon catheter is then deflated and removed with the stent remaining seated within the blood vessel because the stent shows little or no radial retraction.", "Use of radially expandable stents in combination with a PTFE graft is disclosed in U.S. Pat.", "No.", "5,078,726 to Kreamer, which teaches placing a pair of expandable stents within the interior ends of a prosthetic graft, having a length that is sufficient to span the damaged section of a blood vessel.", "The stents are then expanded to secure the graft to the blood vessel wall via a friction fit.", "Although stents and stent/graft combinations have been used to provide endovascular prostheses that are capable of maintaining their fit against blood vessel walls, other desirable features are lacking.", "For instance, features such as increased strength and durability of the prosthesis, as well as an inert, smooth, biocompatible blood flow surface on the luminal surface of the prosthesis and an inert, smooth biocompatible surface on the abluminal surface of the prosthesis, are advantageous characteristics of an implantable vascular graft.", "Some skilled in the art have recently addressed these desirable characteristics by producing strengthened and reinforced prostheses composed entirely of biocompatible grafts and graft layers.", "For example, U.S. Pat.", "No.", "5,048,065, issued to Weldon, et al.", "discloses a reinforced graft assembly comprising a biologic or biosynthetic graft component having a porous surface and a biologic or biosynthetic reinforcing sleeve which is concentrically fitted over the graft component.", "The reinforcing sleeve includes an internal layer, an intermediate layer, and an external layer, all of which comprise biocompatible fibers.", "The sleeve component functions to provide compliant reinforcement to the graft component.", "Further, U.S. Pat.", "No.", "5,163,951, issued to Pinchuk, et al.", "describes a composite vascular graft having an inner component, an intermediate component, and an outer component.", "The inner and outer components are preferably formed of expanded PTFE while the intermediate component is formed of strands of biocompatible synthetic material having a melting point lower than the material which comprises the inner and outer components.", "Another reinforced vascular prosthesis having enhanced compatibility and compliance is disclosed in U.S. Pat.", "No.", "5,354,329, issued to Whalen.", "This patent discloses a non-pyrogenic vascular prosthesis comprising a multilaminar tubular member having an interior stratum, a unitary medial stratum, and an exterior stratum.", "The medial stratum forms an exclusionary boundary between the interior and exterior strata.", "One embodiment of this prosthesis is formed entirely of silicone rubber that comprises different characteristics for the different strata contained within the graft.", "The prior art also includes grafts having increased strength and durability, which have been reinforced with stent-like members.", "For example, U.S. Pat.", "No.", "4,731,073, issued to Robinson, discloses an arterial graft prosthesis comprising a multi-layer graft having a helical reinforcement embedded within the wall of the graft.", "U.S. Pat.", "No.", "4,969,896, issued to Shors describes an inner elastomeric biocompatible tube having a plurality of rib members spaced about the exterior surface of the inner tube, and a perforate flexible biocompatible wrap circumferentially disposed about, and attached to, the rib members.", "Another example of a graft having reinforcing stent-like members is disclosed in U.S. Pat.", "No.", "5,123,917, issued to Lee, which describes an expandable intraluminal vascular graft having an inner flexible cylindrical tube, an outer flexible cylindrical tube concentrically enclosing the inner tube, and a plurality of separate scaffold members positioned between the inner and outer tubes.", "Further, U.S. Pat.", "No.", "5,282,860, issued to Matsuno et al.", "discloses a multi-layer stent comprising an outer resin tube having at least one flap to provide an anchoring means, an inner fluorine-based resin tube and a mechanical reinforcing layer positioned between the inner and outer tubes.", "Still another stent-containing graft is described in U.S. Pat.", "No.", "5,389,106 issued to Tower, which discloses an impermeable expandable intravascular stent including a dispensable frame and an impermeable deformable membrane interconnecting portions of the frame to form an impermeable exterior wall.", "The membrane comprises a synthetic non-latex, non-vinyl polymer while the frame is comprised of a fine platinum wire.", "The membrane is attached to the frame by placing the frame on a mandrel, dipping the frame and the mandrel into a polymer and organic solvent solution, withdrawing the frame and mandrel from the solution, drying the frame and mandrel, and removing the mandrel from the polymer-coated frame.", "Microporous expanded polytetrafluoroethylene (“ePTFE”) tubes may be made by any of a number of well-known methods.", "Expanded PTFE is frequently produced by admixing particulate dry polytetrafluoroethylene resin with a liquid lubricant to form a viscous slurry.", "The mixture is poured into a mold, typically a cylindrical mold, and compressed to form a cylindrical billet.", "The billet is then rammed extruded through an extrusion die into either tubular or sheet structures, termed extrudates in the art.", "The extrudates consist of extruded PTFE-lubricant mixture called “wet PTFE.” Wet PTFE has a microstructure of coalesced, coherent PTFE resin particles in a highly crystalline state.", "Following extrusion, the wet PTFE is heated to a temperature below the flash point of the lubricant to volatilize a major fraction of the lubricant from the PTFE extrudate.", "The resulting PTFE extrudate without a major fraction of lubricant is known in the art as dried PTFE.", "The dried PTFE is then either uniaxially, biaxially or radially expanded using appropriate mechanical apparatus known in the art.", "Expansion is typically carried out at an elevated temperature, e.g., above room temperature but below 327° C., the crystalline melt point of PTFE.", "Uniaxial, biaxial or radial expansion of the dried PTFE causes the coalesced, coherent PTFE resin to form fibrils emanating from nodes (regions of coalesced PTFE), with the fibrils oriented parallel to the axis of expansion.", "Once expanded, the dried PTFE is referred to as expanded PTFE (“ePTFE”) or microporous PTFE.", "The ePTFE is then transferred to an oven where it is sintered by being heated to a temperature above 327° C., the crystalline melt point of PTFE.", "During the sintering process the ePTFE is restrained against uniaxial, biaxial or radial contraction.", "Sintering causes at least a portion of the crystalline PTFE to change from a crystalline state to an amorphous state.", "The conversion from a highly crystalline structure to one having an increased amorphous content locks the node and fibril microstructure, as well as its orientation relative to the axis of expansion, and provides a dimensionally stable tubular or sheet material upon cooling.", "Prior to the sintering step, the lubricant must be removed because the sintering temperature of PTFE is greater than the flash point of commercially available lubricants.", "Sintered ePTFE articles exhibit significant resistance to further uniaxial, or radial expansion.", "This property has led many in the art to devise techniques which entail endoluminal delivery and placement of an ePTFE graft having a desired fixed diameter, followed by endoluminal delivery and placement of an endoluminal prosthesis, such as a stent or other fixation device, to frictionally engage the endoluminal prosthesis within the lumen of the anatomical passageway.", "The Kreamer patent, U.S. Pat.", "No.", "5,078,726, discussed above, exemplifies such use of an ePTFE prosthetic graft.", "Similarly, International Publication Nos.", "WO95/05132 and WO95/05555, filed by W.L.", "Gore Associates, Inc., disclose balloon expandable prosthetic stents which have been covered on inner and outer surfaces by wrapping ePTFE sheet material about the balloon expandable prosthetic stent in its enlarged diameter, sintering the wrapped ePTFE sheet material to secure it about the stent, and crimping the assembly to a reduced diameter for endoluminal delivery.", "Once positioned endoluminally, the stent-graft combination is dilated to re-expand the stent to its enlarged diameter returning the ePTFE wrapping to its original diameter.", "Thus, it is well known in the prior art to provide an ePTFE covering which is fabricated at the final desired endovascular diameter and is endoluminally delivered in a folded or crimped condition to reduce its delivery profile, then unfolded in vivo using either the spring tension of a self-expanding, thermally induced expanding structural support member or a balloon catheter.", "However, the known ePTFE covered endoluminal stents are often covered on only one surface of the stent, i.e., either the luminal or abluminal wall surface of the stent.", "Where the stent is fully covered on both the luminal and abluminal wall surfaces of the stent, the covering completely surrounds the stent elements and fills the stent interstices, thereby encapsulating the stent.", "Examples of patents teaching encapsulated stents and encapsulation techniques include commonly assigned patents: U.S. Pat.", "No.", "5,749,880, U.S. Pat.", "No.", "6,039,755, U.S. Pat.", "No.", "6,124,523, and U.S. Pat.", "No.", "6,451,047, each of which is incorporated into this application as if fully set forth herein.", "When the encapsulated stent is comprised of shape memory alloy, characteristics of the stent make it necessary to encapsulate in the “large” state and then compress the encapsulated stent for delivery.", "In this case, encapsulation either increases the device's resistance to compression, or increases the delivery profile of the device as compression causes the polymeric material to fold or buckle around the stent.", "Perhaps the most serious problem is that the folding during compression actually encompasses folding of the stent itself, which unduly stresses the stent material and may result in structural failure.", "In contrast to the prior art, the present invention provides a method to encapsulate a stent in ePTFE whereby the structure contains pockets or regions where the ePTFE layers are not adhered to one another allowing the stent to contract or expand without being encumbered by ePTFE and without folding or stressing the stent itself.", "As used herein, the following terms have the following meanings: “Fibril” refers to a strand of PTFE material that originates from one or more nodes and terminates at one or more nodes.", "“Node” refers to the solid region within an ePTFE material at which fibrils originate and converge.", "“Internodal Distance” or “IND” refers to a distance between two adjacent nodes measured along the longitudinal axis of fibrils between the facing surfaces of the adjacent nodes.", "IND is usually expressed in micrometers (μm).", "“Node Length” as used herein refers to a distance measured along a straight line between the furthermost end points of a single node which line is perpendicular to the fibrils emanating from the node.", "“Nodal Elongation” as used herein refers to expansion of PTFE nodes in the ePTFE microstructure along the Node Length.", "“Longitudinal Surface” of a node as used herein refers to a nodal surface from which fibrils emanate.", "“Node Width” as used herein refers to a distance measured along a straight line, drawn parallel to the fibrils, between opposing longitudinal surfaces of a node.", "“Plastic Deformation” as used herein refers to the deformation of the ePTFE microstructure under the influence of an expansive force which deforms and increases the Node Length and results in elastic recoil of the ePTFE material less than about 25%.", "“Radially Expandable” as used herein to describe the present invention refers to a property of the ePTFE tubular member to undergo radially oriented Plastic Deformation mediated by Nodal Elongation.", "“Structural Integrity” as used herein to describe the present invention in terms of the ePTFE refers to a condition of the ePTFE microstructure both pre- and post-radial deformation in which the fibrils are substantially free of fractures or breaks and the ePTFE material is free of gross failures; when used to describe the entire device “Structural Integrity” may also include delamination of the ePTFE layers.", "Endoluminal stent devices are typically categorized into two primary types: balloon expandable and self-expanding.", "Of the self-expanding types of endoluminal stent devices, there are two principle sub-categories: elastically self-expanding and thermally self-expanding.", "The balloon expandable stents are typically made of a ductile material, such as stainless steel tube, which has been machined to form a pattern of openings separated by stent elements.", "Radial expansion is achieved by applying a radially outwardly directed force to the lumen of a balloon expandable stent and deforming the stent beyond its elastic limit from a smaller initial diameter to an enlarged final diameter.", "In this process the slots deform into “diamond shapes.” Balloon expandable stents are typically radially and longitudinally rigid and have limited recoil after expansion.", "These stents have superior hoop strength against compressive forces but should this strength be overcome, the devices will deform and not recover.", "Self-expanding stents, on the other hand, are fabricated from either spring metal or shape memory alloy wire which has been woven, wound or formed into a stent having interstices separated with wire stent elements.", "When compared to balloon-expandable stents, these devices have less hoop strength but their inherent resiliency allows them to recover once a compressive force that results in deformation is removed.", "Covered endoluminal stents are known in the art.", "Heretofore, however, the stent covering has been made of a polymeric material which has completely subtended the stent interstices, that is, the stent was completely embedded in the polymeric material.", "This has posed difficulty particularly with the self-expanding stents.", "To preserve their self-expanding property, all covered self-expanding stents have been covered with a polymeric covering while the stent is in its unstrained dimensional condition (i.e., its native enlarged diameter).", "Yet in order to deliver a covered stent, it must be constricted to a smaller delivery diameter.", "Radial compression of a stent necessarily causes the individual stent elements to traverse the stent interstices and pass into proximity to a laterally adjacent individual stent element, thereby occupying the previously open interstitial space.", "Any polymeric material which subtends or resides within the previously open interstitial space will necessarily be displaced, either through shearing, fracturing or otherwise responding to the narrowing of the interstitial space as the stent is compressed from its enlarged unstrained diameter to its strained reduced diameter.", "Because the struts of the stent are completely encapsulated, resistance of the polymer may cause folding or stressing of the struts during compression.", "It was recognized, therefore, that a need has developed to provide an encapsulating covering for a stent which is permanently retained on the stent, substantially isolates the stent material from the body tissue forming the anatomical passageway or from matter within the anatomical passageway, and which permits the stent to deform without substantial interference from the covering material.", "It is, therefore, a primary objective of the present invention to provide a method for encapsulating an endoluminal stent such that the encapsulating covering forms non-adhered regions which act as slip planes or pockets to permit the individual stent elements to traverse a substantial surface area of interstitial space between adjacent stent elements without resistance or interference from the encapsulating covering, thereby avoiding damage or stress to the stent elements.", "It is a further object of the present invention to use the pockets between the bonded regions to contain and deliver therapeutic substances.", "It is another objective of the present invention to provide an apparatus for applying to and selectively adhering sections of the encapsulating covering about the stent, and to provide a selectively adhered encapsulated covered stent-graft device." ], [ "<SOH> BRIEF SUMMARY OF THE INVENTION <EOH>Accordingly, the present invention relates generally to endoluminal stent-graft devices suitable for percutaneous delivery into a body through anatomical passageways to treat injured or diseased areas of the body.", "More particularly, the present invention relates to a method of bonding microporous polytetrafluoroethylene (“PTFE”) coverings over a stent scaffold in a manner which maintains unbonded regions to act as slip planes or pockets to accommodate planar movement of stent elements.", "In one embodiment of the present invention bonded and unbonded regions are formed by means of a mandrel which has a pattern of either raised projections or recesses in its surface which are either synchronous or asynchronous, respectively, with stent elements.", "In one embodiment, an encapsulated stent-graft device is provided in which an endoluminal stent having a plurality of individual stent elements separated by interstitial spaces is circumferentially covered along at least a portion of its longitudinal axis by at least one luminal and at least one abluminal covering of a polymeric material, the luminal and abluminal coverings being selectively adhered to one another at discrete portions thereof in a manner which forms a plurality of open pockets surrounding a plurality of stent elements.", "In another embodiment, a radially expandable reinforced vascular graft includes a first layer of biocompatible flexible material, a second layer of biocompatible flexible material, and a support layer sandwiched between the first and second layers of biocompatible flexible material.", "In one embodiment, a selective bonding system can be advantageously used to produce inflatable pockets by bonding the first layer to the second layer in defined patterns.", "The resulting structure can then be inflated and stiffened by injection of a fluid resulting in a supporting structure without inclusion of a stent.", "A crude analogy might be the construction of an air mattress that is composed of flexible polymeric layers bonded to each other in a predetermined pattern.", "The at least one luminal and at least one abluminal covering of a polymeric material are preferably comprised of expanded PTFE, unexpanded porous PTFE, woven polyester or expanded PTFE yarns, polyimides, silicones, polyurethane, fluoroethylpolypropylene (PEP), polypropylfluorinated amines (PFA), or other related fluorinated polymers.", "The stent may be made of any strong material which can undergo radial expansion but which is also resistant to non-elastic collapse such as silver, titanium, nickel-titanium alloys, stainless steel, gold, or any suitable plastic material capable of maintaining its shape and material properties at sintering temperatures and having the necessary strength and elasticity to enable radial expansion without collapse due to the presence of the polymer coverings.", "A preferred embodiment of the radially expandable reinforced vascular device includes a tubular stent, having a plurality of stent elements and stent interstices, concentrically covered along at least a portion of its longitudinal length by a luminal polymeric covering and an abluminal polymeric covering.", "The luminal and abluminal polymeric coverings are discontinuously joined to one another through some of the stent interstices.", "The luminal and abluminal polymeric coverings may be shorter in length than the stent member to permit opposing stent ends to flare outwardly upon radial expansion of the stent member.", "Alternatively, the ends of the stent member may be completely encased by the luminal and abluminal polymeric coverings.", "The stent member is preferably a self-expanding stent, which may be either an elastic spring material stent, such as a stainless steel stent as disclosed in U.S. Pat.", "No.", "5,266,073 to Wall, a non-woven stainless steel self-expanding stent as disclosed in U.S. Pat.", "No.", "5,282,824 to Gianturco, or a thermoelastic stent made of a shape memory alloy, e.g., a nickel-titanium alloy commonly known as NITINOL, such as that disclosed in U.S. Pat.", "No.", "5,147,370 to McNamara et al., each of which is incorporated by reference into this application as if fully set forth herein.", "As used herein, a tubular shaped support member preferably comprises a stent made of silver, titanium, stainless steel, gold, or any suitable plastic material capable of maintaining its shape and material properties at sintering temperatures and having the strength and elasticity to permit radial expansion and resist radial collapse.", "In accordance with the present invention, selective bonding of expanded PTFE luminal and abluminal layers encapsulates the endoluminal stent and isolates the stent from both the tissue forming the anatomical passageway as well as any fluid, such as blood, bile, urine, etc.", "which may pass through the anatomical passageway.", "The presence of slip planes or pockets formed by the selectively adhered regions of ePTFE: i) permits freedom of movement of stent elements within the encapsulating covering during both expansion and contraction of the stent along either its radial or longitudinal axes; ii) permits uniform folding of the ePTFE stent covering material which is complementary to the structure of the stent element lattice; iii) permits movement of the stent relative to the ePTFE encapsulating layers; iv) reduces forces required to compress or dilate the stent in the case of elastically or thermally self-expanding stents; v) reduces radial expansion pressures required to balloon expand an ePTFE encapsulated stent; and vi) provides void regions which may be used in conjunction with the microporous microstructure of the ePTFE covering material to retain and release bioactive substances, such as anticoagulant drugs, anti-inflammatory drugs, or the like.", "Alternative arrangements of the stent member or other suitable structural support sufficient to maintain the luminal patency of the luminal and abluminal polymer coverings may be employed.", "For example, a radially expandable, articulated reinforced vascular graft may be formed by concentrically interdisposing a structural support assembly comprising multiple stent members spaced apart from one another between two tubular polymer covering members, then partially joining the two tubular polymer covering members by circumferentially compressing selected regions of the two tubular polymer covering members and thermally bonding the selectively compressed regions to one another.", "The present invention also encompasses selective bonding of multiple polymeric layers to create an inflatable structure.", "Such a structure can be inflated by fluids delivered through lumens within the delivery catheter.", "The selective bonding method allows creation of devices with multiple adjacent channels or pockets.", "Some of these pockets can be pre-filled with a therapeutic drug to prevent restenosis or local thrombosis.", "Alternate pockets can be arranged for fluid inflation after the device is inserted.", "One method of making the foregoing encapsulated stent-graft is to join concentrically a luminal polymeric tube, an endoluminal stent, and an abluminal polymeric tube and to place the assembly onto a mandrel having a plurality of raised projections separated by land areas, or by a plurality of land areas separated by a plurality of recesses.", "Either the raised projections or the land areas are patterned to match a pattern of either the stent elements of the stent interstices, both the stent elements and stent interstices or portions of each.", "In this way the projections or the landed areas exert pressure, respectively on select regions of the PTFE resulting in limited regions of adherence or fusion when the device is heated to sintering temperatures.", "Using a mandrel, luminal pressure is selectively applied to produce selectively placed bonds.", "As will become clear, bonding pressure can be applied from the luminal or the abluminal or both surfaces of the device.", "The present invention is also directed to a process for making a radially expandable reinforced stent-graft device by: a) positioning a radially expandable stent member including a plurality of interconnected stent elements and a plurality of interstices between adjacent interconnected stent elements, concentrically over a first polymeric cover member; b) positioning a second polymer cover member concentrically over the radially expandable stent member and the first polymeric cover member; c) selectively joining portions of the first polymeric cover member and the second polymeric cover member through a plurality of the interstices of the stent member, while leaving portions of the first and second polymeric cover members unjoined and forming slip planes or pockets to accommodate movement of at least a portion of the interconnected stent elements therethrough; and d) fully joining opposing end regions of the first and second polymer cover members through the interstices of the stent member proximate to opposing ends of the stent member.", "Fixing the support layer to the biocompatible graft layers includes selectively applying pressure to the portions of the luminal and abluminal polymer covers after they are loaded onto a mandrel and then heating the resulting assembly at sintering temperatures to form a mechanical bond at the selected areas of applied pressure.", "Alternatively, a pattern of at least one of an adhesive, an aqueous dispersion of polytetrafluoroethylene, a polytetrafluoroethylene tape, fluoroethylpolypropylene (PEP), or tetrafluoroethylene (collectively the “adhesive”) may be introduced between the luminal and abluminal polymer covers at selected positions, followed by heating the assembly to the melt temperature of the adhesive to bond the luminal and abluminal polymer covers while leaving unbonded slip plane regions to accommodate movement of the stent elements.", "If ultraviolet curable adhesives are used, a UV laser or a photolithography system can be used to create the bond pattern.", "Many thermoplastic polymers such as polyethylene, polypropylene, polyurethane and polyethylene terephthalate can also be used.", "If pieces of one of these or similar polymers are placed or attached to one of the polymer covers in the region to be bonded, heat and pressure will melt the thermoplastic causing it to flow into the pores of the ePTFE, thereby bonding the ePTFE layers together.", "These and other embodiments, features and advantages will become more apparent to those skilled in the art when taken with reference to the following more detailed description of the invention in conjunction with the accompanying drawings that are first briefly described." ], [ "PRIORITY This application is a continuation of U.S. application Ser.", "No.", "15/348,180, filed Nov. 10, 2016, which is a division of U.S. application Ser.", "No.", "14/310,527, filed Jun.", "20, 2014, now U.S. Pat.", "No.", "9,492,269, which is a continuation of U.S. application Ser.", "No.", "13/225,028, filed Sep. 2, 2011, now U.S. Pat.", "No.", "8,790,241, which is a continuation of U.S. application Ser.", "No.", "11/363,689, filed Feb. 27, 2006, now U.S. Pat.", "No.", "8,012,194, which is a continuation of U.S. application Ser.", "No.", "10/410,589, filed Apr.", "9, 2003, now U.S. Pat.", "No.", "7,004,966, which is a continuation of U.S. application Ser.", "No.", "09/1764,811, filed Jan. 16, 2001, now U.S. Pat.", "No.", "6,547,814, which is a division of U.S. application Ser.", "No.", "09/409,209, filed Sep. 30, 1999, now U.S. Pat.", "No.", "6,245,099, which claims the benefit under 35 U.S.C.", "§ 119(e) to U.S.", "Provisional Application No.", "60/1102,518, filed Sep. 30, 1998, each of which is incorporated by reference into this application as if fully set forth herein.", "BACKGROUND OF THE INVENTION The use of implantable vascular grafts comprised of PTFE is well known in the art.", "These grafts are typically used to replace or repair damaged or occluded blood vessels within the body.", "However, if such grafts are radially expanded within a blood vessel, they will exhibit some subsequent retraction.", "Further, such grafts usually require additional means for anchoring the graft within the blood vessel, such as sutures, clamps, or similarly functioning elements.", "To minimize the retraction and eliminate the requirement for additional attachment means, those skilled in the art have used stents, such as those presented by Palmaz in U.S. Pat.", "No.", "4,733,665 and Gianturco in U.S. Pat.", "No.", "4,580,568, which are incorporated by reference into this application as if fully set forth herein, either alone or in combination with PTFE grafts.", "For example, the stent described by Palmaz in U.S. Pat.", "No.", "4,733,665 can be used to repair an occluded blood vessel.", "The stent is introduced into the blood vessel via a balloon catheter, which is then positioned at the occluded site of the blood vessel.", "The balloon is then expanded, thereby expanding the overlying stent to a diameter comparable to the diameter of an unoccluded blood vessel.", "The balloon catheter is then deflated and removed with the stent remaining seated within the blood vessel because the stent shows little or no radial retraction.", "Use of radially expandable stents in combination with a PTFE graft is disclosed in U.S. Pat.", "No.", "5,078,726 to Kreamer, which teaches placing a pair of expandable stents within the interior ends of a prosthetic graft, having a length that is sufficient to span the damaged section of a blood vessel.", "The stents are then expanded to secure the graft to the blood vessel wall via a friction fit.", "Although stents and stent/graft combinations have been used to provide endovascular prostheses that are capable of maintaining their fit against blood vessel walls, other desirable features are lacking.", "For instance, features such as increased strength and durability of the prosthesis, as well as an inert, smooth, biocompatible blood flow surface on the luminal surface of the prosthesis and an inert, smooth biocompatible surface on the abluminal surface of the prosthesis, are advantageous characteristics of an implantable vascular graft.", "Some skilled in the art have recently addressed these desirable characteristics by producing strengthened and reinforced prostheses composed entirely of biocompatible grafts and graft layers.", "For example, U.S. Pat.", "No.", "5,048,065, issued to Weldon, et al.", "discloses a reinforced graft assembly comprising a biologic or biosynthetic graft component having a porous surface and a biologic or biosynthetic reinforcing sleeve which is concentrically fitted over the graft component.", "The reinforcing sleeve includes an internal layer, an intermediate layer, and an external layer, all of which comprise biocompatible fibers.", "The sleeve component functions to provide compliant reinforcement to the graft component.", "Further, U.S. Pat.", "No.", "5,163,951, issued to Pinchuk, et al.", "describes a composite vascular graft having an inner component, an intermediate component, and an outer component.", "The inner and outer components are preferably formed of expanded PTFE while the intermediate component is formed of strands of biocompatible synthetic material having a melting point lower than the material which comprises the inner and outer components.", "Another reinforced vascular prosthesis having enhanced compatibility and compliance is disclosed in U.S. Pat.", "No.", "5,354,329, issued to Whalen.", "This patent discloses a non-pyrogenic vascular prosthesis comprising a multilaminar tubular member having an interior stratum, a unitary medial stratum, and an exterior stratum.", "The medial stratum forms an exclusionary boundary between the interior and exterior strata.", "One embodiment of this prosthesis is formed entirely of silicone rubber that comprises different characteristics for the different strata contained within the graft.", "The prior art also includes grafts having increased strength and durability, which have been reinforced with stent-like members.", "For example, U.S. Pat.", "No.", "4,731,073, issued to Robinson, discloses an arterial graft prosthesis comprising a multi-layer graft having a helical reinforcement embedded within the wall of the graft.", "U.S. Pat.", "No.", "4,969,896, issued to Shors describes an inner elastomeric biocompatible tube having a plurality of rib members spaced about the exterior surface of the inner tube, and a perforate flexible biocompatible wrap circumferentially disposed about, and attached to, the rib members.", "Another example of a graft having reinforcing stent-like members is disclosed in U.S. Pat.", "No.", "5,123,917, issued to Lee, which describes an expandable intraluminal vascular graft having an inner flexible cylindrical tube, an outer flexible cylindrical tube concentrically enclosing the inner tube, and a plurality of separate scaffold members positioned between the inner and outer tubes.", "Further, U.S. Pat.", "No.", "5,282,860, issued to Matsuno et al.", "discloses a multi-layer stent comprising an outer resin tube having at least one flap to provide an anchoring means, an inner fluorine-based resin tube and a mechanical reinforcing layer positioned between the inner and outer tubes.", "Still another stent-containing graft is described in U.S. Pat.", "No.", "5,389,106 issued to Tower, which discloses an impermeable expandable intravascular stent including a dispensable frame and an impermeable deformable membrane interconnecting portions of the frame to form an impermeable exterior wall.", "The membrane comprises a synthetic non-latex, non-vinyl polymer while the frame is comprised of a fine platinum wire.", "The membrane is attached to the frame by placing the frame on a mandrel, dipping the frame and the mandrel into a polymer and organic solvent solution, withdrawing the frame and mandrel from the solution, drying the frame and mandrel, and removing the mandrel from the polymer-coated frame.", "Microporous expanded polytetrafluoroethylene (“ePTFE”) tubes may be made by any of a number of well-known methods.", "Expanded PTFE is frequently produced by admixing particulate dry polytetrafluoroethylene resin with a liquid lubricant to form a viscous slurry.", "The mixture is poured into a mold, typically a cylindrical mold, and compressed to form a cylindrical billet.", "The billet is then rammed extruded through an extrusion die into either tubular or sheet structures, termed extrudates in the art.", "The extrudates consist of extruded PTFE-lubricant mixture called “wet PTFE.” Wet PTFE has a microstructure of coalesced, coherent PTFE resin particles in a highly crystalline state.", "Following extrusion, the wet PTFE is heated to a temperature below the flash point of the lubricant to volatilize a major fraction of the lubricant from the PTFE extrudate.", "The resulting PTFE extrudate without a major fraction of lubricant is known in the art as dried PTFE.", "The dried PTFE is then either uniaxially, biaxially or radially expanded using appropriate mechanical apparatus known in the art.", "Expansion is typically carried out at an elevated temperature, e.g., above room temperature but below 327° C., the crystalline melt point of PTFE.", "Uniaxial, biaxial or radial expansion of the dried PTFE causes the coalesced, coherent PTFE resin to form fibrils emanating from nodes (regions of coalesced PTFE), with the fibrils oriented parallel to the axis of expansion.", "Once expanded, the dried PTFE is referred to as expanded PTFE (“ePTFE”) or microporous PTFE.", "The ePTFE is then transferred to an oven where it is sintered by being heated to a temperature above 327° C., the crystalline melt point of PTFE.", "During the sintering process the ePTFE is restrained against uniaxial, biaxial or radial contraction.", "Sintering causes at least a portion of the crystalline PTFE to change from a crystalline state to an amorphous state.", "The conversion from a highly crystalline structure to one having an increased amorphous content locks the node and fibril microstructure, as well as its orientation relative to the axis of expansion, and provides a dimensionally stable tubular or sheet material upon cooling.", "Prior to the sintering step, the lubricant must be removed because the sintering temperature of PTFE is greater than the flash point of commercially available lubricants.", "Sintered ePTFE articles exhibit significant resistance to further uniaxial, or radial expansion.", "This property has led many in the art to devise techniques which entail endoluminal delivery and placement of an ePTFE graft having a desired fixed diameter, followed by endoluminal delivery and placement of an endoluminal prosthesis, such as a stent or other fixation device, to frictionally engage the endoluminal prosthesis within the lumen of the anatomical passageway.", "The Kreamer patent, U.S. Pat.", "No.", "5,078,726, discussed above, exemplifies such use of an ePTFE prosthetic graft.", "Similarly, International Publication Nos.", "WO95/05132 and WO95/05555, filed by W.L.", "Gore Associates, Inc., disclose balloon expandable prosthetic stents which have been covered on inner and outer surfaces by wrapping ePTFE sheet material about the balloon expandable prosthetic stent in its enlarged diameter, sintering the wrapped ePTFE sheet material to secure it about the stent, and crimping the assembly to a reduced diameter for endoluminal delivery.", "Once positioned endoluminally, the stent-graft combination is dilated to re-expand the stent to its enlarged diameter returning the ePTFE wrapping to its original diameter.", "Thus, it is well known in the prior art to provide an ePTFE covering which is fabricated at the final desired endovascular diameter and is endoluminally delivered in a folded or crimped condition to reduce its delivery profile, then unfolded in vivo using either the spring tension of a self-expanding, thermally induced expanding structural support member or a balloon catheter.", "However, the known ePTFE covered endoluminal stents are often covered on only one surface of the stent, i.e., either the luminal or abluminal wall surface of the stent.", "Where the stent is fully covered on both the luminal and abluminal wall surfaces of the stent, the covering completely surrounds the stent elements and fills the stent interstices, thereby encapsulating the stent.", "Examples of patents teaching encapsulated stents and encapsulation techniques include commonly assigned patents: U.S. Pat.", "No.", "5,749,880, U.S. Pat.", "No.", "6,039,755, U.S. Pat.", "No.", "6,124,523, and U.S. Pat.", "No.", "6,451,047, each of which is incorporated into this application as if fully set forth herein.", "When the encapsulated stent is comprised of shape memory alloy, characteristics of the stent make it necessary to encapsulate in the “large” state and then compress the encapsulated stent for delivery.", "In this case, encapsulation either increases the device's resistance to compression, or increases the delivery profile of the device as compression causes the polymeric material to fold or buckle around the stent.", "Perhaps the most serious problem is that the folding during compression actually encompasses folding of the stent itself, which unduly stresses the stent material and may result in structural failure.", "In contrast to the prior art, the present invention provides a method to encapsulate a stent in ePTFE whereby the structure contains pockets or regions where the ePTFE layers are not adhered to one another allowing the stent to contract or expand without being encumbered by ePTFE and without folding or stressing the stent itself.", "As used herein, the following terms have the following meanings: “Fibril” refers to a strand of PTFE material that originates from one or more nodes and terminates at one or more nodes.", "“Node” refers to the solid region within an ePTFE material at which fibrils originate and converge.", "“Internodal Distance” or “IND” refers to a distance between two adjacent nodes measured along the longitudinal axis of fibrils between the facing surfaces of the adjacent nodes.", "IND is usually expressed in micrometers (μm).", "“Node Length” as used herein refers to a distance measured along a straight line between the furthermost end points of a single node which line is perpendicular to the fibrils emanating from the node.", "“Nodal Elongation” as used herein refers to expansion of PTFE nodes in the ePTFE microstructure along the Node Length.", "“Longitudinal Surface” of a node as used herein refers to a nodal surface from which fibrils emanate.", "“Node Width” as used herein refers to a distance measured along a straight line, drawn parallel to the fibrils, between opposing longitudinal surfaces of a node.", "“Plastic Deformation” as used herein refers to the deformation of the ePTFE microstructure under the influence of an expansive force which deforms and increases the Node Length and results in elastic recoil of the ePTFE material less than about 25%.", "“Radially Expandable” as used herein to describe the present invention refers to a property of the ePTFE tubular member to undergo radially oriented Plastic Deformation mediated by Nodal Elongation.", "“Structural Integrity” as used herein to describe the present invention in terms of the ePTFE refers to a condition of the ePTFE microstructure both pre- and post-radial deformation in which the fibrils are substantially free of fractures or breaks and the ePTFE material is free of gross failures; when used to describe the entire device “Structural Integrity” may also include delamination of the ePTFE layers.", "Endoluminal stent devices are typically categorized into two primary types: balloon expandable and self-expanding.", "Of the self-expanding types of endoluminal stent devices, there are two principle sub-categories: elastically self-expanding and thermally self-expanding.", "The balloon expandable stents are typically made of a ductile material, such as stainless steel tube, which has been machined to form a pattern of openings separated by stent elements.", "Radial expansion is achieved by applying a radially outwardly directed force to the lumen of a balloon expandable stent and deforming the stent beyond its elastic limit from a smaller initial diameter to an enlarged final diameter.", "In this process the slots deform into “diamond shapes.” Balloon expandable stents are typically radially and longitudinally rigid and have limited recoil after expansion.", "These stents have superior hoop strength against compressive forces but should this strength be overcome, the devices will deform and not recover.", "Self-expanding stents, on the other hand, are fabricated from either spring metal or shape memory alloy wire which has been woven, wound or formed into a stent having interstices separated with wire stent elements.", "When compared to balloon-expandable stents, these devices have less hoop strength but their inherent resiliency allows them to recover once a compressive force that results in deformation is removed.", "Covered endoluminal stents are known in the art.", "Heretofore, however, the stent covering has been made of a polymeric material which has completely subtended the stent interstices, that is, the stent was completely embedded in the polymeric material.", "This has posed difficulty particularly with the self-expanding stents.", "To preserve their self-expanding property, all covered self-expanding stents have been covered with a polymeric covering while the stent is in its unstrained dimensional condition (i.e., its native enlarged diameter).", "Yet in order to deliver a covered stent, it must be constricted to a smaller delivery diameter.", "Radial compression of a stent necessarily causes the individual stent elements to traverse the stent interstices and pass into proximity to a laterally adjacent individual stent element, thereby occupying the previously open interstitial space.", "Any polymeric material which subtends or resides within the previously open interstitial space will necessarily be displaced, either through shearing, fracturing or otherwise responding to the narrowing of the interstitial space as the stent is compressed from its enlarged unstrained diameter to its strained reduced diameter.", "Because the struts of the stent are completely encapsulated, resistance of the polymer may cause folding or stressing of the struts during compression.", "It was recognized, therefore, that a need has developed to provide an encapsulating covering for a stent which is permanently retained on the stent, substantially isolates the stent material from the body tissue forming the anatomical passageway or from matter within the anatomical passageway, and which permits the stent to deform without substantial interference from the covering material.", "It is, therefore, a primary objective of the present invention to provide a method for encapsulating an endoluminal stent such that the encapsulating covering forms non-adhered regions which act as slip planes or pockets to permit the individual stent elements to traverse a substantial surface area of interstitial space between adjacent stent elements without resistance or interference from the encapsulating covering, thereby avoiding damage or stress to the stent elements.", "It is a further object of the present invention to use the pockets between the bonded regions to contain and deliver therapeutic substances.", "It is another objective of the present invention to provide an apparatus for applying to and selectively adhering sections of the encapsulating covering about the stent, and to provide a selectively adhered encapsulated covered stent-graft device.", "BRIEF SUMMARY OF THE INVENTION Accordingly, the present invention relates generally to endoluminal stent-graft devices suitable for percutaneous delivery into a body through anatomical passageways to treat injured or diseased areas of the body.", "More particularly, the present invention relates to a method of bonding microporous polytetrafluoroethylene (“PTFE”) coverings over a stent scaffold in a manner which maintains unbonded regions to act as slip planes or pockets to accommodate planar movement of stent elements.", "In one embodiment of the present invention bonded and unbonded regions are formed by means of a mandrel which has a pattern of either raised projections or recesses in its surface which are either synchronous or asynchronous, respectively, with stent elements.", "In one embodiment, an encapsulated stent-graft device is provided in which an endoluminal stent having a plurality of individual stent elements separated by interstitial spaces is circumferentially covered along at least a portion of its longitudinal axis by at least one luminal and at least one abluminal covering of a polymeric material, the luminal and abluminal coverings being selectively adhered to one another at discrete portions thereof in a manner which forms a plurality of open pockets surrounding a plurality of stent elements.", "In another embodiment, a radially expandable reinforced vascular graft includes a first layer of biocompatible flexible material, a second layer of biocompatible flexible material, and a support layer sandwiched between the first and second layers of biocompatible flexible material.", "In one embodiment, a selective bonding system can be advantageously used to produce inflatable pockets by bonding the first layer to the second layer in defined patterns.", "The resulting structure can then be inflated and stiffened by injection of a fluid resulting in a supporting structure without inclusion of a stent.", "A crude analogy might be the construction of an air mattress that is composed of flexible polymeric layers bonded to each other in a predetermined pattern.", "The at least one luminal and at least one abluminal covering of a polymeric material are preferably comprised of expanded PTFE, unexpanded porous PTFE, woven polyester or expanded PTFE yarns, polyimides, silicones, polyurethane, fluoroethylpolypropylene (PEP), polypropylfluorinated amines (PFA), or other related fluorinated polymers.", "The stent may be made of any strong material which can undergo radial expansion but which is also resistant to non-elastic collapse such as silver, titanium, nickel-titanium alloys, stainless steel, gold, or any suitable plastic material capable of maintaining its shape and material properties at sintering temperatures and having the necessary strength and elasticity to enable radial expansion without collapse due to the presence of the polymer coverings.", "A preferred embodiment of the radially expandable reinforced vascular device includes a tubular stent, having a plurality of stent elements and stent interstices, concentrically covered along at least a portion of its longitudinal length by a luminal polymeric covering and an abluminal polymeric covering.", "The luminal and abluminal polymeric coverings are discontinuously joined to one another through some of the stent interstices.", "The luminal and abluminal polymeric coverings may be shorter in length than the stent member to permit opposing stent ends to flare outwardly upon radial expansion of the stent member.", "Alternatively, the ends of the stent member may be completely encased by the luminal and abluminal polymeric coverings.", "The stent member is preferably a self-expanding stent, which may be either an elastic spring material stent, such as a stainless steel stent as disclosed in U.S. Pat.", "No.", "5,266,073 to Wall, a non-woven stainless steel self-expanding stent as disclosed in U.S. Pat.", "No.", "5,282,824 to Gianturco, or a thermoelastic stent made of a shape memory alloy, e.g., a nickel-titanium alloy commonly known as NITINOL, such as that disclosed in U.S. Pat.", "No.", "5,147,370 to McNamara et al., each of which is incorporated by reference into this application as if fully set forth herein.", "As used herein, a tubular shaped support member preferably comprises a stent made of silver, titanium, stainless steel, gold, or any suitable plastic material capable of maintaining its shape and material properties at sintering temperatures and having the strength and elasticity to permit radial expansion and resist radial collapse.", "In accordance with the present invention, selective bonding of expanded PTFE luminal and abluminal layers encapsulates the endoluminal stent and isolates the stent from both the tissue forming the anatomical passageway as well as any fluid, such as blood, bile, urine, etc.", "which may pass through the anatomical passageway.", "The presence of slip planes or pockets formed by the selectively adhered regions of ePTFE: i) permits freedom of movement of stent elements within the encapsulating covering during both expansion and contraction of the stent along either its radial or longitudinal axes; ii) permits uniform folding of the ePTFE stent covering material which is complementary to the structure of the stent element lattice; iii) permits movement of the stent relative to the ePTFE encapsulating layers; iv) reduces forces required to compress or dilate the stent in the case of elastically or thermally self-expanding stents; v) reduces radial expansion pressures required to balloon expand an ePTFE encapsulated stent; and vi) provides void regions which may be used in conjunction with the microporous microstructure of the ePTFE covering material to retain and release bioactive substances, such as anticoagulant drugs, anti-inflammatory drugs, or the like.", "Alternative arrangements of the stent member or other suitable structural support sufficient to maintain the luminal patency of the luminal and abluminal polymer coverings may be employed.", "For example, a radially expandable, articulated reinforced vascular graft may be formed by concentrically interdisposing a structural support assembly comprising multiple stent members spaced apart from one another between two tubular polymer covering members, then partially joining the two tubular polymer covering members by circumferentially compressing selected regions of the two tubular polymer covering members and thermally bonding the selectively compressed regions to one another.", "The present invention also encompasses selective bonding of multiple polymeric layers to create an inflatable structure.", "Such a structure can be inflated by fluids delivered through lumens within the delivery catheter.", "The selective bonding method allows creation of devices with multiple adjacent channels or pockets.", "Some of these pockets can be pre-filled with a therapeutic drug to prevent restenosis or local thrombosis.", "Alternate pockets can be arranged for fluid inflation after the device is inserted.", "One method of making the foregoing encapsulated stent-graft is to join concentrically a luminal polymeric tube, an endoluminal stent, and an abluminal polymeric tube and to place the assembly onto a mandrel having a plurality of raised projections separated by land areas, or by a plurality of land areas separated by a plurality of recesses.", "Either the raised projections or the land areas are patterned to match a pattern of either the stent elements of the stent interstices, both the stent elements and stent interstices or portions of each.", "In this way the projections or the landed areas exert pressure, respectively on select regions of the PTFE resulting in limited regions of adherence or fusion when the device is heated to sintering temperatures.", "Using a mandrel, luminal pressure is selectively applied to produce selectively placed bonds.", "As will become clear, bonding pressure can be applied from the luminal or the abluminal or both surfaces of the device.", "The present invention is also directed to a process for making a radially expandable reinforced stent-graft device by: a) positioning a radially expandable stent member including a plurality of interconnected stent elements and a plurality of interstices between adjacent interconnected stent elements, concentrically over a first polymeric cover member; b) positioning a second polymer cover member concentrically over the radially expandable stent member and the first polymeric cover member; c) selectively joining portions of the first polymeric cover member and the second polymeric cover member through a plurality of the interstices of the stent member, while leaving portions of the first and second polymeric cover members unjoined and forming slip planes or pockets to accommodate movement of at least a portion of the interconnected stent elements therethrough; and d) fully joining opposing end regions of the first and second polymer cover members through the interstices of the stent member proximate to opposing ends of the stent member.", "Fixing the support layer to the biocompatible graft layers includes selectively applying pressure to the portions of the luminal and abluminal polymer covers after they are loaded onto a mandrel and then heating the resulting assembly at sintering temperatures to form a mechanical bond at the selected areas of applied pressure.", "Alternatively, a pattern of at least one of an adhesive, an aqueous dispersion of polytetrafluoroethylene, a polytetrafluoroethylene tape, fluoroethylpolypropylene (PEP), or tetrafluoroethylene (collectively the “adhesive”) may be introduced between the luminal and abluminal polymer covers at selected positions, followed by heating the assembly to the melt temperature of the adhesive to bond the luminal and abluminal polymer covers while leaving unbonded slip plane regions to accommodate movement of the stent elements.", "If ultraviolet curable adhesives are used, a UV laser or a photolithography system can be used to create the bond pattern.", "Many thermoplastic polymers such as polyethylene, polypropylene, polyurethane and polyethylene terephthalate can also be used.", "If pieces of one of these or similar polymers are placed or attached to one of the polymer covers in the region to be bonded, heat and pressure will melt the thermoplastic causing it to flow into the pores of the ePTFE, thereby bonding the ePTFE layers together.", "These and other embodiments, features and advantages will become more apparent to those skilled in the art when taken with reference to the following more detailed description of the invention in conjunction with the accompanying drawings that are first briefly described.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a process flow diagram illustrating a preferred method of making a stent-graft device FIG.", "2 is a perspective view of a mandrel having longitudinal ridges or splines.", "FIG.", "3 is a cross-section view of the mandrel shown in FIG.", "2.FIG.", "4 is a perspective view of a stent-graft device illustrating selected regions of bonding between the luminal and abluminal stent covers and a plurality of slip plane pockets intermediate the luminal and abluminal stent covers.", "FIG.", "5 is a cross-sectional view taken along line 5-5 of FIG.", "4.FIG.", "6 is a scanning electron micrograph illustrating a selectively bonded region and a slip plane pocket with a stent element residing therein.", "FIG.", "7 is a perspective view of a mandrel having circumferential ridges (as opposed to longitudinal splines).", "FIG.", "8 is a flow diagram showing a method of using adhesives to create selective adherence.", "FIG.", "9 is a flow diagram of an alternative method of using adhesives to create selective bonds.", "DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The following detailed description should be read with reference to the drawings, in which like elements in different drawings are identically numbered.", "The drawings, which are not necessarily to scale, depict selected embodiments and are not intended to limit the scope of the invention.", "The detailed description illustrates by way of example, not by way of limitation, the principles of the invention.", "This description will clearly enable one skilled in the art to make and use the invention, and describes several embodiments, adaptations, variations, alternatives and uses of the invention, including what is presently believed to be the best mode of carrying out the invention.", "The selective adherence encapsulation of the present invention is an improvement to the total adherence method taught in U.S. Pat.", "No.", "5,749,880 that is incorporated by reference into this application as if fully set forth herein.", "The '880 patent discloses a method for encapsulating a support stent by placing the stent over a first tubular member of unsintered ePTFE and then placing a second tubular member of unsintered ePTFE coaxially over the stent so that the stent is sandwiched between two layers of ePTFE.", "Radial force is applied either internally or externally to force the first tubular member into contact with the stent and into contact with the second tubular members through openings in the stent or, respectively, to force the second tubular into contact with the stent and into contact with the first tubular member through openings in the stent.", "Finally, the compound structure is exposed to an elevated temperature to bond the first tubular member to the second tubular member wherever they are pressed into contact.", "In one embodiment an adhesive spread between the tubular members achieves the bonding.", "In a preferred embodiment the elevated temperature is a sintering temperature (above the crystalline melting point of PTFE) and direct PTFE to PTFE bonds form.", "As mentioned above, a potential drawback of this approach is that when the radial dimensions of the stent change, movement of components of the stent (necessary for radial dimensional changes) may be impeded by surrounding ePTFE.", "If the stent is encapsulated in an expanded form and then reduced in diameter prior to insertion into a patient, the encapsulating ePTFE may significantly increase the force needed to compress the stent and may fold in a manner so as to increase the profile of the collapsed device.", "If the bonding of the first member to the second member is selective, i.e., does not occur through all available openings in the stent, slip planes or pockets will be left in the structure so that stent components can reorient within these pockets without encountering resistance from the ePTFE.", "Without the slip planes formed by the selective bonds of the present invention, crimping a shape memory stent may cause the stent members to fold or otherwise become stressed.", "This can result in permanent damage to the stent.", "There is a considerable possible range of extent for the selective adherence of the instant invention.", "At one extreme is a fully encapsulated stent as provided by the '880 patent in which there is full bonding between all areas of the two tubular members in which the stent struts do not block contact.", "At the other extreme would be a “spot welded” device where only tiny areas, probably in the middle of the open areas of the stent structure, are bonded.", "At that extreme, there might be a tendency for the PTFE members to separate from the stent should the spot weld bond strength be exceeded; however, the spot weld structure would provide virtually no impedance to radial deformation of the stent.", "The optimum extent of selective adherence, as well as the geometric position of the bonds in relation to the stent, depends on the structure of the stent as well as the desired properties of the completed device.", "Complete control of the bond positions can be achieved by a numerically controlled (NC) machine in which the two-ePTFE members with the interposed stent are mounted on a mandrel that is attached to the spindle drive of a modified NC lathe.", "In this device a heated tool whose tip is equal to the desired spot weld area is automatically pressed onto the mandrel-mounted ePTFE-stent sandwich in proper registration to create a bond in an open region between components or struts of the stent.", "The tool moves away slightly as the mandrel turns to expose another open region and the tool then moves in to create a second bond and so on.", "Depending on the distance that the mandrel turns, the spot welds may be in adjacent open spaces or may skip one or more open spaces.", "As the mandrel is turned, the tool advances along the longitudinal axis of the mandrel so that virtually any patterns of spot welds can be created on the ePTFE-stent device.", "The precise pattern is under computer control and an entire stent can be treated quite quickly.", "If the design calls for spot welds of different surface areas, the stent can be treated with different tools (e.g., different areas) in several passes.", "An ultrasonic welding tip can readily be substituted for the heated tool.", "It is also possible to use radiant energy, as with a laser, to effect similar results.", "However, the inventors presently believe that pressure as well as heat are needed for the best bonds.", "Currently, laser-induced bonds do not appear to be as strong as bonds that are made with heat and pressure unless a curable adhesive system (as with a UV laser) is employed.", "Splined or textured mandrels can also be used to apply selective heat and pressure to create selective adherence between the ePTFE members.", "By “spline or splined” is meant a cylindrical structure with longitudinally oriented ridges equally spaced about the structure's circumference.", "Wherever the first and second ePTFE tubular members come into contact a bond can be formed if heat and pressure are applied.", "If the ePTFE tubular members and support stent are placed over a mandrel whose surface is patterned with elevated and depressed regions (hills and valleys), the elevated regions or ridges will apply pressure to the overlying stent-ePTFE regions allowing selective bonding of those regions.", "Regions of ePTFE overlying valleys will not be pressed together and no bond will form there.", "That is, the pattern of the mandrel will be translated into an identical pattern of bonded regions in the stent-graft device.", "To make this translation, the process diagram of FIG.", "1 is followed, as described below.", "In a first step 32, a first ePTFE tubular member is placed on a mandrel.", "Preferably, the first tubular member is composed of unsintered ePTFE.", "In a second step 34, a stent device is placed over the first tubular member.", "In a third step 36, a second ePTFE tubular member is slid coaxially over the stent.", "The second tubular member may be unsintered or partially sintered.", "Use of a partially sintered second tubular member reduces the chance of tearing the member while pulling it over the stent.", "It will be apparent to one of skill in the art that there is an advantage to using a second tubular member with a slightly larger diameter than the first tubular member.", "However, if the second tubular member is too large, folds or creases may develop during the bonding process.", "This entire process may use one of the textured mandrels that will be described below.", "However, it is also possible to assemble one or both tubular members and the stent on a smooth mandrel and then slip the assembly off the smooth mandrel and onto the textured mandrel.", "If the fit is fairly tight, it may be easier to place the stent over the first tubular member when that member is supported by a smooth mandrel.", "Also, there may be a limited number of textured mandrels available for production so that making a number of ePTFE-stent assemblies on less expensive smooth mandrels may result in a significant savings of time.", "If a smooth mandrel is used, the stent assembly is transferred to a textured mandrel before the next step (wrapping) occurs.", "In a fourth step 38, the ePTFE-stent assembly is helically wrapped with PTFE “tape.” This tape is actually a long, thin strip of PTFE of the type generally known as “plumber's tape.” The tape is evenly wound over the stent device so that the device is covered from end to end.", "The tape is wound so that the long axis of the tape is approximately normal (offset by 10-) 15° to the long axis of the stent device.", "Ideally, there should be some overlap of the tape covering the device so that coverage is even and complete.", "In fact an overlap ratio wherein five revolutions is needed to progress one tape width has proven effective.", "The tape should be applied with a controlled and even tension so that it is sufficiently tight to apply pressure at right angles to the surface of the stent device.", "One way of achieving this is to use a force clutch on the tape spool to ensure a reproducible tension in the tape as it is wound over the stent device.", "While this process can be performed by hand, it is fairly easy to automate the winding process by having the mandrel mounted in a modified lathe.", "As the lathe spindle turns, the spool of tape automatically advances along the turning mandrel ensuring an even and reproducible wrapping.", "In a fifth step 42, the wrapped assembly is then placed into an oven at a temperature above or nearly equal to the crystalline melting temperature of ePTFE.", "The wrapping applies pressure to regions of ePTFE that are underlaid by raised portions of the textured mandrel.", "The oven provides the necessary heat to cause a strong ePTFE-ePTFE bond to form in these regions.", "The sintering time can vary from a few minutes to a few tens of minutes.", "The overall time depends to some extent on the mass of the mandrel.", "If the mandrel is solid, it may take a considerable time for the surface of the mandrel to reach sintering temperatures.", "The process can be speeded up by using a hollow mandrel or even a mandrel containing a heating element so that the ePTFE is rapidly brought to a sintering temperature.", "A thermistor or similar temperature sensor is advantageous embedded into the surface of the mandrel so that it is possible to determine when the ePTFE reaches sintering temperature.", "In this way the process can be accurately timed.", "In the final step 44, the tape is removed from the mandrel (after cooling) and the finished device is removed.", "Results in this step indicate the success of the sintering step 42.If sintering time or temperature is excessive, there may be some bonding of the PTFE tape to the stent device.", "The solution is to reduce the sintering time and/or temperature in future sintering.", "This is one reason that time, temperature and wrapping force should be carefully controlled.", "This problem can also be avoided by using means other than PTFE wrapping to apply pressure to the device during the sintering process.", "At first glance it would appear that the radial pressure can be applied by a “clam shell” heating device that clamps around the stent device and mandrel.", "However, such a device is not capable of applying even radial pressure.", "One possible solution is to divide the clam shell device into a number of segments, preferably at least six, each of which is equipped with pressure means to force the segment radially towards the center of textured mandrel.", "Similarly, the mandrel can be divided into segments or otherwise be capable of an increase in diameter (e.g., by formation from a material having a large coefficient of expansion upon temperature increase) to create radial pressure between the surface of the mandrel and the surrounding clam shell device.", "An additional method of achieving bond pressure without wrapping is to use a clamshell device having an inner surface relief mirroring the textured mandrel.", "That is, there would be ridges and valleys that would exactly register with the ridges and valleys on the mandrel when the shell is closed.", "Similarly, a flat surface could be provided with ridges and valleys matching the mandrel surface if that surface were unrolled onto a flat plane.", "With such a surface it is possible to roll the mandrel in contact and registration with the flat pattern so that defined pressure is applied to the raised mandrel regions.", "The downward force applied to the mandrel controls the bond pressure while the rate of rolling controls the time a given bond is under pressure.", "This process can be carried out in an oven or the mandrel and surface can contain heating elements.", "One method of ensuring registration between the mandrel pattern and the flat surface pattern is to have gears attached to one or both ends of the mandrel mesh with a toothed rack that runs along one or both edges of the patterned surface.", "Contact pressure is controlled by weight of the mandrel or by a mechanical linkage that applies a controlled downward force to the mandrel.", "To this point no mandrel patterns or textures have been described.", "It will be clear to one skilled in the art that this invention permits a complex pattern wherein the entire stent structure is mirrored by the valleys and ridges of the mandrel with the structural members of the stent fitting into the valleys and the apices of the ridges or raised portions falling at discrete points within the open areas of the stent.", "What may be somewhat less obvious is that far simpler patterns can also produce excellent results in the present invention.", "One simple mandrel design is a “splined” mandrel wherein the mandrel has a number of longitudinal ridges (splines) so that a cross-section of the mandrel looks something like a toothed gear.", "FIG.", "2 shows a perspective view of such a mandrel 20 with longitudinal splines 22.FIG.", "3 shows a cross section of the mandrel 20 wherein it is apparent that the splines 22 have rounded edges to avoid damaging or cutting the surface of the ePTFE.", "FIG.", "4 shows a perspective view of an encapsulated stent 30 made on the splined mandrel 20.The stent 46 is composed of struts 48 arranged in a diamond pattern.", "Regions 52 at the ends of the device (marked by cross-hatching) have complete bonding between the two ePTFE tubular members.", "This region is produced by smooth, non-splined regions of the mandrel.", "Dotted lines 54 mark the position of the splines and the resulting regions of selective bonding.", "That is, the device has spaced apart bonded regions running the length of the open diamond regions 56.Because of this orientation, successive tiers of diamond regions 56 along the longitudinal axis of the device are alternately bonded and unbonded.", "FIG.", "6 shows a scanning electron micrograph of an oblique section through a longitudinally selectively bonded stent 44.A cross-section of the strut 48 is shown as well as a bonded region 54 and an unbonded slip pocket 62.The unbonded pockets 62 allow free movement of the stent struts 48.However, even those diamond regions 56 containing bonds 54 allow relatively unimpeded movement of the struts 48 because the bond 54 is only down the central part of the diamond region 56—relatively distant from the struts 48.Tests show that the selectively bonded stent 30 can be radially compressed with considerably less force than a stent that is encapsulated by uniformly bonding all regions where the ePTFE tubular members contact each other.", "The longitudinal bonds somewhat restrict longitudinal compression of the device as the bonded regions buckle less readily than unbonded ePTFE.", "The longitudinal bonds 54 do restrict the side to side flexibility or bendability of the device to some extent.", "In some applications this stiffening of the device is desirable while in other applications one needs a stent device that is able to bend more freely.", "Increased lateral flexibility can be achieved by using a mandrel with radial ridges rather than longitudinal ridges as shown in FIG.", "7.Again the ridges 58 are spaced apart in relation to the strut 48 spacing in the stent to be encapsulated.", "If the stent 46 shown in FIG.", "4 is used, the radial ridges 58 can be spaced apart to place circumferential bonds through alternate tiers of diamond regions 56.The resulting device is more bendable laterally than the version with longitudinal bonds.", "In addition, the circumferential bonds result in a device that is more easily compressed longitudinally.", "It is clear that the area and orientation of the bond regions influence the properties of the final device.", "For example, a helical pattern of ridges produces a device with intermediate properties: it is more laterally bendable that the longitudinally bonded device of FIG.", "4, but it has more resistance to longitudinal compression than does a device with circumferential bonds.", "The pitch of the helical pattern controls the overall effect with shallow pitches acting more like circumferential ridges and steep pitches acting more like longitudinal ridges.", "Multiple helices can be used with opposing (e.g., clockwise and counter clockwise) ridges, producing a device that is more resistant to lateral bending.", "Virtually any combination of the described patterns can be used to produce devices having a preferred direction of bendability or devices that resist longitudinal compression in one region while permitting such compression in another.", "The stent device illustrated in the figures is one in which the stent struts form courses or diamond-shaped spaces and the struts continue from course to course to create an extended tubular device.", "Stents are also available which consist of only a single course (or segment) of diamond-shapes.", "The current method can advantageously be used to combine a number of these segments together to make an extended tubular device.", "Frequently, these single segment stents consist of an alternation of larger and smaller diamond shapes.", "For example, the segments can be arranged with large diamonds touching large diamonds.", "Other arrangements included a “twisted” design wherein each successive segment is rotationally offset and an “alternating” design wherein alternate segment are rotated so that a given large diamond is bounded on either side by a small diamond.", "The precise properties of the resulting encapsulated device depend on these factors.", "However, the significant thing about the prior art encapsulation is that it produced a device that is relatively stiff and unbending.", "Various adhesives (as opposed to directly adhering PTFE to PTFE) can also be used to create the pattern of bonded regions.", "FIG.", "8 shows a diagram of one method for using adhesives to create selective bonds.", "In a first step 32, a tubular graft member is placed on a support such as a mandrel.", "In a second step 34, a stent (or stents) is placed over the first graft member.", "In a third step 64, a coating of adhesive is placed over the stent graft combination.", "This adhesive is one that is “activatable” meaning that the material is not inherently sticky as it is applied.", "However, it can be activated by applying heat, light or some other energy so that it hardens or otherwise changes to form a permanent bond.", "In the next step 64, a second tubular member is placed over the adhesive-coated stent.", "In the final step 66, a pattern of desired bonds is inscribed on the device with, for example, a laser or a heated probe or a photolithographic mask image.", "The inscribing process provides energy to local regions of the structure to activate the adhesive and create selectively bonded regions.", "A number of different activatable adhesive materials can be used in the present invention.", "One such material might be a layer or coating of a thermoplastic such as polyethylene.", "This material can be activated by heat that melts it so that it flows into the pores of the ePTFE.", "After cooling, the plastic hardens so that the PTFE of one tubular member is bonded to the other tubular member." ] ]
Patent_15876029
[ [ "VEHICLE DISPLAY DEVICE", "A vehicle display device is configured for installation to a vehicle and includes a mirror element configured to reflect external light entering from a front surface toward the front surface, and a light emitting device.", "The light emitting device includes a light source configured to emit light, and a light guide element configured to guide incident light from the light source.", "The light guide element includes an emission surface configured to output incident light, and an optical-path changing portion configured to change the optical path of incident light toward the emission surface.", "The mirror element and the light guide element are stacked at an outer surface of the mirror element to allow the optical-path changing portion to change the optical path." ], [ "1.A vehicle display device configured for installation to a vehicle, the vehicle display device comprising: a mirror element configured to reflect external light entering from a front surface toward the front surface; and a light emitting device; wherein the light emitting device comprises: a light source configured to emit light, and a light guide element configured to guide incident light from the light source, wherein the light guide element comprises: an emission surface configured to output incident light, and an optical-path changing portion configured to change the optical path of incident light toward the emission surface, and wherein the mirror element and the light guide element are stacked at an outer surface of the mirror element to allow the optical-path changing portion to change the optical path.", "2.The vehicle display device according to claim 1, wherein the light guide element is panel-like, and wherein the light guide element is stacked on the mirror element at an outer surface of the mirror element.", "3.The vehicle display device according to claim 1, wherein the mirror element comprises: a thin-film transmissive portion configured with one surface as a front surface, and a reflective layer formed on the other surface of the transmissive portion and configured to reflect external light entering from the front surface and passing through the transmissive portion toward the front surface, and wherein the light guide element is arranged at the other surface of the mirror element.", "4.A vehicle display device configured for installation to a vehicle, the vehicle display device comprising: a light emitting device, wherein the light emitting device comprises: a light source configured to emit light, and a panel-like light guide element configured to guide incident light from the light source, and wherein the light guide element comprises: an emission surface configured to output incident light from the light source; and an optical-path changing portion configured to change the path of incident light from the light source toward the emission surface, and wherein a reflective layer is formed on the surface facing the emission surface of the light guide element, that is configured to reflect external light entering from the emission surface and passing through the light guide element toward the emission surface.", "5.A vehicle display device configured for installation to a vehicle, the vehicle display device comprising: a light emitting device, wherein the light emitting device comprises: a light source configured to emit light, and a panel-like light guide element configured to guide incident light from the light source, and wherein the light guide element comprises: an emission surface configured to output incident light from the light source, an optical-path changing portion configured to change the path of incident light, a transmissive layer formed on the surface facing the emission surface of the light guide element and configured to allow external light entering from the emission surface and passing through the light guide element to pass therethrough, and a reflective layer configured to reflect external light passing through the transmissive layer toward the emission surface.", "6.The vehicle display device according claim 1, wherein the optical-path changing portion changes the optical path toward the outside of the host vehicle to which the vehicle display device is installed.", "7.The vehicle display device according to claim 1, further comprising: an attachment configured for mounting on a vehicle, wherein the light guide element is arranged so the light source emits light from near the attachment.", "8.The vehicle display device according to claim 1, wherein the vehicle display device configured for installation to a vehicle to serve as a door mirror.", "9.", "(canceled) 10.", "(canceled) 11.The vehicle display device according claim 2, wherein the optical-path changing portion changes the optical path toward the outside of the host vehicle to which the vehicle display device is installed.", "12.The vehicle display device according claim 3, wherein the optical-path changing portion changes the optical path toward the outside of the host vehicle to which the vehicle display device is installed.", "13.The vehicle display device according claim 4, wherein the optical-path changing portion changes the optical path toward the outside of the host vehicle to which the vehicle display device is installed.", "14.The vehicle display device according claim 5, wherein the optical-path changing portion changes the optical path toward the outside of the host vehicle to which the vehicle display device is installed.", "15.The vehicle display device according to claim 2, further comprising: an attachment configured for mounting on a vehicle, wherein the light guide element is arranged so the light source emits light from near the attachment.", "16.The vehicle display device according to claim 3, further comprising: an attachment configured for mounting on a vehicle, wherein the light guide element is arranged so the light source emits light from near the attachment.", "17.The vehicle display device according to claim 4, further comprising: an attachment configured for mounting on a vehicle, wherein the light guide element is arranged so the light source emits light from near the attachment.", "18.The vehicle display device according to claim 5, further comprising: an attachment configured for mounting on a vehicle, wherein the light guide element is arranged so the light source emits light from near the attachment.", "19.The vehicle display device according to claim 6, further comprising: an attachment configured for mounting on a vehicle, wherein the light guide element is arranged so the light source emits light from near the attachment.", "20.The vehicle display device according to claim 2, wherein the vehicle display device configured for installation to a vehicle to serve as a door mirror.", "21.The vehicle display device according to claim 3, wherein the vehicle display device configured for installation to a vehicle to serve as a door mirror.", "22.The vehicle display device according to claim 4, wherein the vehicle display device configured for installation to a vehicle to serve as a door mirror." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>One or more embodiments of the present invention provides a vehicle display device that is easily visible from other vehicles by using a door mirror or window pane so that the mirror surface or window surface emits the light.", "A vehicle display device according to one or more embodiments of the present invention is configured for installation to a vehicle and includes: a mirror element configured to reflect external light entering from a front surface toward the front surface; and a light emitting device; the light emitting device including: a light source configured to emit light; and a light guide element configured to guide incident light from the light source; the light guide element including: an emission surface configured to output incident light; and an optical-path changing portion configured to change the optical path of incident light toward the emission surface; and the mirror element and the light guide element are stacked at an outer surface of the mirror element to allow the optical-path changing portion to change the optical path.", "In the vehicle display device described herein: the light guide element is panel-like, and is stacked on the mirror element at an outer surface of the mirror element.", "In the vehicle display device described herein the mirror element includes: a thin-film transmissive portion configured with one surface as a front surface; and a reflective layer formed on the other surface of the transmissive portion and configured to reflect external light entering from the front surface and passing through the transmissive portion toward the front surface; and the light guide element is arranged at the other surface of the mirror element.", "A vehicle display device described herein is configured for installation to a vehicle, and includes: a light emitting device; the light emitting device including: a light source configured to emit light; and a panel-like light guide element configured to guide incident light from the light source; and the light guide element including: an emission surface configured to output incident light from the light source; and an optical-path changing portion configured to change the path of incident light from the light source toward the emission surface; and a reflective layer formed on the surface facing the emission surface of the light guide element and configured to reflect external light entering from the emission surface and passing through the light guide element toward the emission surface.", "A vehicle display device described herein is configured for installation to a vehicle and includes: a light emitting device; the light emitting device including: a light source configured to emit light; and a panel-like light guide element configured to guide incident light from the light source; and the light guide element including: an emission surface configured to output incident light from the light source; and an optical-path changing portion configured to change the path of incident light; a transmissive layer formed on the surface facing the emission surface of the light guide element and configured to allow external light entering from the emission surface and passing through the light guide element to pass therethrough; and a reflective layer configured to reflect external light passing through the transmissive layer toward the emission surface.", "In the vehicle display device described herein the optical-path changing portion changes the optical path toward the outside of the host vehicle to which the vehicle display device is installed.", "The vehicle display device described herein further includes: an attachment configured for mounting on a vehicle; and the light guide element is arranged so the light source emits light from near the attachment.", "The vehicle display device described herein the vehicle display device is configured for installation to a vehicle to serve as a door mirror.", "A vehicle display device described herein is configured for installation to a vehicle, and includes: a window material; and a light emitting device; the light emitting device including: a light source configured to emit light; and a light guide element configured to guide incident light from the light source; the light guide element including: an emission surface configured to output incident light; and an optical-path changing portion configured to change the optical path of incident light toward the emission surface; and the window material and the light guide element are stacked.", "A vehicle display device described herein is configured for installation to a vehicle, and includes: a light emitting device; the light emitting device including: a light source configured to emit light; and a panel-like light guide element configured to guide incident light from the light source, and to serve as window material; the light guide element including: an emission surface configured to output incident light from the light source; and an optical-path changing portion configured to change the path of incident light from the light source toward the emission surface.", "The vehicle display device described herein is provided with a light emitting device that includes a light source and a light guide element that may be attached to a door mirror or a window pane, and the vehicle display device is configured to emit light." ], [ "BACKGROUND Field The present invention relates to a vehicle display device that may be installed on a vehicle.", "Related Art It is increasingly common for a door mirror to incorporate a turn signal, allowing the door mirror with the built-in turn signal to function as a vehicle display device.", "Japanese Patent Publication No.", "2008-94215 discloses a turn signal provided with a light source and an oblong light guide material; the turn signal is attached to the door mirror and emits light lengthwise.", "However, only a portion of the door mirror body emits light among the vehicle display devices of the related art.", "Therefore, a vehicle display device that emits light easily visible to other vehicles is desired.", "The door mirror disclosed in Japanese Patent Publication No.", "2008-94215 is similar.", "Since the oblong light guide material is simply attached to the mirror body, the door mirror has a small light emission area.", "Thus, a more easily visible light emitting surface area is desired.", "SUMMARY One or more embodiments of the present invention provides a vehicle display device that is easily visible from other vehicles by using a door mirror or window pane so that the mirror surface or window surface emits the light.", "A vehicle display device according to one or more embodiments of the present invention is configured for installation to a vehicle and includes: a mirror element configured to reflect external light entering from a front surface toward the front surface; and a light emitting device; the light emitting device including: a light source configured to emit light; and a light guide element configured to guide incident light from the light source; the light guide element including: an emission surface configured to output incident light; and an optical-path changing portion configured to change the optical path of incident light toward the emission surface; and the mirror element and the light guide element are stacked at an outer surface of the mirror element to allow the optical-path changing portion to change the optical path.", "In the vehicle display device described herein: the light guide element is panel-like, and is stacked on the mirror element at an outer surface of the mirror element.", "In the vehicle display device described herein the mirror element includes: a thin-film transmissive portion configured with one surface as a front surface; and a reflective layer formed on the other surface of the transmissive portion and configured to reflect external light entering from the front surface and passing through the transmissive portion toward the front surface; and the light guide element is arranged at the other surface of the mirror element.", "A vehicle display device described herein is configured for installation to a vehicle, and includes: a light emitting device; the light emitting device including: a light source configured to emit light; and a panel-like light guide element configured to guide incident light from the light source; and the light guide element including: an emission surface configured to output incident light from the light source; and an optical-path changing portion configured to change the path of incident light from the light source toward the emission surface; and a reflective layer formed on the surface facing the emission surface of the light guide element and configured to reflect external light entering from the emission surface and passing through the light guide element toward the emission surface.", "A vehicle display device described herein is configured for installation to a vehicle and includes: a light emitting device; the light emitting device including: a light source configured to emit light; and a panel-like light guide element configured to guide incident light from the light source; and the light guide element including: an emission surface configured to output incident light from the light source; and an optical-path changing portion configured to change the path of incident light; a transmissive layer formed on the surface facing the emission surface of the light guide element and configured to allow external light entering from the emission surface and passing through the light guide element to pass therethrough; and a reflective layer configured to reflect external light passing through the transmissive layer toward the emission surface.", "In the vehicle display device described herein the optical-path changing portion changes the optical path toward the outside of the host vehicle to which the vehicle display device is installed.", "The vehicle display device described herein further includes: an attachment configured for mounting on a vehicle; and the light guide element is arranged so the light source emits light from near the attachment.", "The vehicle display device described herein the vehicle display device is configured for installation to a vehicle to serve as a door mirror.", "A vehicle display device described herein is configured for installation to a vehicle, and includes: a window material; and a light emitting device; the light emitting device including: a light source configured to emit light; and a light guide element configured to guide incident light from the light source; the light guide element including: an emission surface configured to output incident light; and an optical-path changing portion configured to change the optical path of incident light toward the emission surface; and the window material and the light guide element are stacked.", "A vehicle display device described herein is configured for installation to a vehicle, and includes: a light emitting device; the light emitting device including: a light source configured to emit light; and a panel-like light guide element configured to guide incident light from the light source, and to serve as window material; the light guide element including: an emission surface configured to output incident light from the light source; and an optical-path changing portion configured to change the path of incident light from the light source toward the emission surface.", "The vehicle display device described herein is provided with a light emitting device that includes a light source and a light guide element that may be attached to a door mirror or a window pane, and the vehicle display device is configured to emit light.", "EFFECTS A vehicle display device according to embodiments of the present invention may be applied to a door mirror or window pane configured for installation to a vehicle.", "The vehicle display device is provided with a light emitting device which includes a light source and a light guide element, where the light emitting device changes the path light travels so the that the mirror surface or window surface radiates light and the light is emitted.", "Thus, embodiments of the present invention exhibit superior benefits, such as improving the visibility to other vehicles.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a schematic plan view illustrating an example of the external features of a vehicle with a door mirror mounted thereon; and the door mirror using a vehicle display device according to a first embodiment of the present invention; FIG.", "2A and FIG.", "2B are schematic perspective views illustrating an example of the external features of a door mirror that uses a vehicle display device according to the first embodiment of the present invention; FIG.", "3 is a schematic diagram for describing a light emitting device in the vehicle display device according to the first embodiment of the present invention; FIG.", "4 is a conceptual diagram depicting an optical path through a cross section of a light emitting device in the vehicle display device according to the first embodiment of the present invention; FIG.", "5 is a schematic perspective view illustrating one example of a part of the internal structure for a door mirror using a vehicle display device according to the first embodiment of the present invention; FIG.", "6 is a schematic front view illustrating a part of the internal structure for a door mirror using a vehicle display device according to the first embodiment of the present invention; FIG.", "7 is a schematic cross-sectional view illustrating a part of the internal structure for a door mirror using a vehicle display device according to the first embodiment of the present invention; FIG.", "8 is a schematic cross-sectional view illustrating a part of the internal structure for a door mirror using a vehicle display device according to the first embodiment of the present invention; FIG.", "9 is a schematic view illustrating the optical path through a light emitting device provided with a vehicle display device according to the first embodiment of the present invention; FIG.", "10 is a schematic cross-sectional view illustrating an example of the internal structure for a door mirror using a vehicle display device according to a second embodiment of the present invention; FIG.", "11 is a schematic view illustrating the optical path through a light emitting device in a vehicle display device according to the second embodiment of the present invention; FIG.", "12 is a schematic view illustrating the optical path through a light emitting device in a vehicle display device according to a third embodiment of the present invention; FIG.", "13 is a schematic view illustrating the optical path through a light emitting device in a vehicle display device according to a fourth embodiment of the present invention; FIG.", "14A, FIG.", "14B, and FIG.", "14C are schematic diagrams for describing an example where a vehicle display device according to a fifth embodiment of the present invention is applied to a vehicle window pane; FIG.", "15 is a schematic diagram for describing an example where a vehicle display device according to the fifth embodiment of the present invention is applied to a vehicle window pane; FIG.", "16 is a schematic view illustrating the optical path through a light emitting device in a vehicle display device according to a fifth embodiment of the present invention; FIG.", "17 is a schematic view illustrating the optical path through a light emitting device in a vehicle display device according to a sixth embodiment of the present invention; and FIG.", "18 is a schematic view illustrating the optical path through a light emitting device in a vehicle display device according to a seventh embodiment of the present invention.", "DETAILED DESCRIPTION Embodiments of the present invention are described in detail with reference to the drawings.", "Note that the following working example is merely an embodiment of the present invention and in no way limits the technical character of the present invention.", "First Embodiment FIG.", "1 is a schematic plan view illustrating an example of the external features of a vehicle with a door mirror mounted thereon, the door mirror using a vehicle display device according to a first embodiment of the present invention; The reference number 1 represents a vehicle; a vehicle display device according to an embodiment of the invention is adopted in a door mirror 2 which is installed on the vehicle 1.The door mirror 2 includes a built-in light emitting device 3 (later described; refer to FIG.", "3); the light emitting device 3 emits highly directional light.", "FIG.", "1 is a plan view of the vehicle 1 and depicts the range of visibility for light emitted from the light emitting device 3 installed in the left-side door mirror 2 as oblique lines.", "The light emitting device 3 emits directional light that is oriented outward from the host vehicle 1.Thus light emitted from the light emitting device 3 can be seen outside the vehicle 1 as illustrated in FIG.", "1, for instance in a vehicle behind the vehicle 1.However, passengers in the vehicle 1, and especially the driver seated in the driver seat cannot see the light emitted from the light emitting device 3; passengers see an ordinary mirror.", "Note that the right side door mirror 2 (not shown) functions identically.", "FIG.", "2A and FIG.", "2B are schematic perspective views illustrating an example of the appearance of a door mirror that uses a vehicle display device according to the first embodiment of the present invention; FIG.", "2A illustrates the door mirror 2 in a normal state; FIG.", "2B illustrates when the built-in light emitting device 3 emits light.", "The entire mirror surface of the door mirror 2 radiates light when the light emitting device 3 emits light.", "Therefore, a larger surface area radiates light compared to when the edge portion of the door mirror 2 lighting up lengthwise, for instance, the light emitted can be easily seen outside the vehicle 1, e.g., from a vehicle following the vehicle 1.Light Emitting Device Next, the principles governing a light emitting device 3 in a vehicle display device (door mirror 2) according to embodiments of the invention is described.", "FIG.", "3 is a schematic diagram for describing a light emitting device provided to the vehicle display device according to the first embodiment of the present invention; and FIG.", "4 is a conceptual diagram depicting an optical path through a cross section of a light emitting device in a vehicle display device according to the first embodiment of the present invention.", "Note that the drawings are provided as outlines or schematic views to facilitate a simple and easy-to-understand description.", "There are also cases where the drawings referenced in the description contain elements that are not drawn to scale in terms of the horizontal and vertical proportions or the spaces between components.", "The light emitting device 3 is provided with a light source 30 that emits light and a light guide plate 31 (light guide element) that guides the incident light from the light source 30.The light source 30 may be configured using a light emitting element such as an LED with the light emitted from the light source 10 entering the light guide plate 31.The light guide plate 31 may be formed from a flexible thin-film material or curable sheet into a rectangular panel-like shape using a transparent resin having a high refractive index such as a polycarbonate (PC) resin or poly methyl methacrylate (PMMA) resin, or using an inorganic material such as glass.", "Here “panel like” indicates an object that is shorter in the thickness direction (thickness) than in the planar direction spreading out in two dimensions orthogonal to the thickness direction.", "That is, while the light guide plate 31 is a rectangular parallelepiped, the length thereof in the thickness direction is less than the length in a plane spreading out in two dimensions and formed by the longitudinal direction and the transverse direction.", "The light source 30 is installed at one end surface in the longitudinal direction of the light guide plate 31.That is, one of the surfaces making up the short side of the rectangle in the thickness direction is the incidence end surface 32 where light emitted from the light source 30 enters.", "The light guide plate 31 causes light entering therein from the incidence end surface 32 to spread out in planar form in the light guide plate 31.The panel-like light guide plate 31 includes an emission surface 33 configured to emit incident light from the light source 30 and a rear surface 34 relative to and across from the emission surface 33.A plurality of optical-path changing portions 35 are formed on the rear surface 34 of the light guide plate 31.The optical-path changing portions 35 change the path of incident light that enters from the incidence end surface 32; in other words, the optical-path changing portions 35 modifies light by a prescribed angle toward the emission surface 33.Here, the optical-path changing portions 35 are illustrated as optical surfaces formed inside the light guide plate 31, and in this particular case, as reflection surfaces 35a that reflect incident light entering from the incidence end surface 32.Oblique notches may be cut into the rear surface 34 with the inclined surfaces serving as the reflection surfaces 35a.", "The light entering the light guide plate 31 is directed to each of the optical-path changing portions 35, and each of the optical-path changing portions 35 modifies the optical path of light incident at positions thereon by a prescribed angle with the light exiting from the emission surface 33 toward a prescribed direction.", "As illustrated in FIG.", "3, the light source 30 is installed at the incidence end surface 32 of the light guide plate 31, and the incidence end surface 32 and the emission surface 33 are substantially orthogonal.", "Additionally, the rear surface 34 faces the emission surface 33, and the rear surface 34 is also substantially orthogonal to the incidence end surface 32.The rear surface 34 is a flat surface substantially parallel to the emission surface 33 and is provided with inclined surfaces that form the optical-path changing portions 35.The flat rear surface 34 along with the emission surface 33 directs the incident light entering the light guide plate 31 from the incidence end surface 32 via total internal reflection therebetween and function to spread the light in the light guide plate 31 in planar form.", "The inclined surfaces forming the optical-path changing portions 35 serve as the reflection surfaces 35a and reflect incident light entering the light guide plate 31 to modify the optical path thereof toward the emission surface 33.That is, the light emitted from the light source 30 and incident on the light guide plate 31 from the incidence end surface 32 is repeatedly totally reflected between the emission surface 33 and the rear surface 34 within the light guide plate 31 and propagates therethrough in planar form.", "On arriving at a reflection surface 35a formed in the optical-path changing portions 35, the light propagating through the light guide plate 31 is reflected by the reflection surface 35a and exits to the outside from the emission surface 33.The reflection surfaces 35a here serve as the optical-path changing portions 35.However, the optical-path changing portions 35 can have various forms so long as the optical-path changing portions 35 can change the path of incident light traveling through the light guide plate 31.For instance, the optical-path changing portions 35 may be formed as a cylindrical Fresnel lens, whereby the refraction effect of the refraction surface of the Fresnel lens (i.e.", "the prism surface) changes the path of the incident light.", "Additionally, in this case the Fresnel lens may be constituted by a plurality of parts with gaps therebetween.", "The optical-path changing portions 35 may also be formed as a diffraction grating whereby the diffraction effect may change the optical path of the incident light.", "Moreover, the reflection effect and the refraction effect of the prism may change the optical path of the incident light.", "A vehicle display device provided with such kind of light emitting device 3 makes it possible to implement various kinds of door mirrors 2.Embodiments of the various internal structures possible for implementing the door mirror 2 using the vehicle display device are described.", "First Embodiment FIG.", "5 is a schematic perspective view illustrating one example of a part of the internal structure for a door mirror using a vehicle display device according to the first embodiment of the present invention.", "FIG.", "6 is a schematic front view illustrating a part of the internal structure for a door mirror using a vehicle display device according to the first embodiment of the present invention.", "FIG.", "7 and FIG.", "8 are schematic cross-sectional views illustrating a part of the internal structure for a door mirror using a vehicle display device according to the first embodiment of the present invention.", "FIG.", "5 and FIG.", "6 depict parts that can be seen when some components of the light emitting device 3 are removed from the door mirror 2.FIG.", "7 schematically illustrates an arrangement of the light emitting device 3 and the mirror element 20 inside the door mirror 2 as seen from above.", "FIG.", "8 is an exploded view of the components in the light emitting device 3 and the mirror element 20 inside the door mirror 2 as seen from above.", "The door mirror 2 is provided with a housing 21 that accommodates the various components in the light emitting device 3 and the mirror element 20.The front plane of the housing 21 is open and the rim includes a gap which allows the mirror element 20 to block the opening when the mirror element 20 is fitted to the housing 21.The housing 21 is provided with a drive mechanism 22 capable of changing the angle of the mirror element 20; the mirror element is secured to the drive mechanism 22.The housing 21 may also be installed on the vehicle 1 by way of an attachment 23; the attachment 23 contains various kinds of communication wiring for connecting the various electrical components in the mirror unit 20 such as the light source 30 of the light emitting device 3 in the door mirror 2 and the drive mechanism 22 to units in the vehicle 1 such as a control device.", "The driver may manipulate various operational input buttons arranged near the driver seat which operates the drive mechanism 22 and adjusts the angle of the mirror element 20.Initiating operations such as a lane change may also cause the light source 30 to emit light.", "A fastener frame 24 acts as a border inside the housing 21 and secures the light guide plate 31 and the mirror element 20 to the drive mechanism 22; the light guide plate 31 and the mirror element 20 are housed within the fastener frame 24 and thereby blocks the opening in the front surface of the housing 21.The fastener frame 24 includes a fastening panel at the rear so that securing the fastening panel to the drive mechanism 22 fastens the light guide plate 31 and mirror element 20 housed within the fastener frame 24 to the drive mechanism 22.The light guide plate 31 appears as a rectangle when viewed from the front, with the light guide plate 31 arranged so that the long side direction and the short side direction thereof are substantially parallel to the horizontal direction on the vertical direction respectively.", "The light source 30 is arranged at the light guide plate 31 near the attachment 23 emits light from near the attachment 23.Arranging the light source so that incident light enters the light guide plate from near the attachment 23 facilitates adjusting the optical path towards outside the vehicle 1.Note that the light guide plate 31 may be configured from a flexible transparent panel, and the end portion of the light guide plate 31 near the light source 30 may be bent so that the light source is arranged behind the drive mechanism 22.Even in this case, the components may be arranged so that light emitted from the light source 30 enters the light guide plate 31 from near the attachment 23.The light guide plate 31 may be arranged behind the mirror element 20 within the fastener frame 24.The mirror element 20 and the light guide plate 31 may be securely adhered to the fastener panel as necessary with an adhesive agent.", "The mirror element 20 is provided a transmissive portion 20b, a front surface 20a in front of the transmissive portion 20b, and a reflective layer 20c behind the transmissive portion 20b.", "Light enters the mirror element 20 through the front surface 20a, passes through the transmissive portion 20b and reflects from the reflective layer 20c.", "The transmissive portion 20b may be produced using a resin material such as transparent polycarbonate resin or poly methyl methacrylate resin, or an inorganic material such as glass.", "The reflective layer 20c may be a metal-plated or vapor-deposited layer produced by plating or depositing a metal such as aluminum or silver.", "The reflective layer 20c reflects light entering from the front surface 20a of the mirror element 20 whereby the mirror element 20 functions as a mirror.", "The door mirror 2 with a vehicle display device according to the first embodiment of the present invention applied thereto is configured with the light guide plate 31 stacked behind the mirror element 20.More specifically, the mirror element 20 and the light guide plates 31 behind the mirror element 20 are stacked so that the respective panel-like surfaces are parallel.", "In other words, the mirror element 20 is a thin panel-like component provided with a transmissive portion 20b, a front surface 20a as one surface on the front part of the transmissive portion 20b, and a reflective layer 20c as the other surface on the back surface of the transmissive portion 20b.", "Light enters the mirror element 20 through the front surface 20a, passes through the transmissive portion 20b and reflects from the reflective layer 20c toward the front surface 20a.", "The light guide plate 31 is arranged at the other surface of the mirror element 20.The optical functions of the first embodiment of the present invention thusly configured are described.", "FIG.", "9 is a conceptual diagram illustrating the optical path through the light emitting device 3 in a vehicle display device according to the first embodiment of the present invention.", "FIG.", "9 superimposes a solid arrow and a double-line arrow over a schematic cross-sectional view of the light emitting device 3 according to the first embodiment; here, the solid arrow represents the optical path of light emitted from the light source 30, while double-line arrow represent the path of external light entering from outside.", "Light emitted from the light source 30 enters the light guide plate 31 from near the attachment 23.The light guide plate 31 guides the incident light from the light source 30 so that the light is repeatedly totally reflected between the emission surface 33 and the rear surface 34; the light is reflected from the optical-path changing portions 35 (omitted from FIG.", "9), and exits from the emission surface 33.Light exiting the light guide plate 31 from the emission surface 33 passes through the mirror element 20 and exits from the door mirror 2.The mirror element 20 functions as a mirror by causing external light to enter through the front surface 20a, pass through the transmissive portion 20b, and reflect from reflective layer 20c to pass through the front surface 20a to the outside.", "Given that the light guide plate 31 does not affect the light entering from outside, an image will not be distorted on reflection from the mirror element 20.The first embodiment, thusly configured may be adopted in a vehicle display device with a light emitting device 3 therein to serve as a door mirror 2.The light emitting device 3 in the vehicle display device (door mirror 2) includes a light source 30 and a light guide plate 31.The vehicle display device functions identically to an ordinary mirror in a door mirror 2 when a driver in the driver seat views the door mirror 2.Outside the vehicle 1, for instance when viewed from a vehicle behind the vehicle 1, the entire mirror surface of the vehicle display device functions as a light emitting device 3 capable of emitting light, and the emission of light may provide various alerts on the operation of the vehicle, e.g., indicating the direction of the vehicle and the like.", "More specifically, the vehicle display device operates as a turn indicator (i.e., turn signal) when one of the left or right door mirrors 2 provided to the vehicle emits light.", "When both vehicle display devices emit light, the vehicle display device functions as a brake indicator (i.e., brake signal).", "Moreover, when both vehicle display devices emit lights, and especially when blinking at predetermined intervals, the vehicle display device functions as an emergency display signal (hazard signal).", "Thus, the vehicle display device emits light whereby various kinds of information may be provided outside the vehicle, for instance, to the driver in a following vehicle.", "The mirror element 20 housed in the door mirror 2 is arranged in front of the light guide plate 31; therefore, the image reflected by the mirror element 20 does not give rise to certain phenomena such as distortion due to effects from the light guide plate 31.Second Embodiment The second embodiment changes the locations of the light guide plate 31 and the mirror element 20 in the vehicle display device of the first embodiment.", "Given that only the location of the light guide plate 31 and the mirror element 20 changes in the second embodiment and all other configurations are identical to the first embodiment, it is sufficient to reference the first embodiment for these configurations as further descriptions thereof are omitted.", "The identical parts in the first and second embodiments are given the same reference numerals.", "FIG.", "10 is a schematic cross-sectional view illustrating an example of the internal structure for a door mirror 2 using a vehicle display device according to a second embodiment of the present invention.", "FIG.", "10 depicts that door mirror 2 provided with a vehicle display device according to a second embodiment of the present invention, and schematically illustrates an arrangement of the light emitting device 3 and the mirror element 20 inside the door mirror 2 when viewed from above.", "The light guide plate 31 is arranged in front of the mirror element 20 in the vehicle display device according to the second embodiment of the present invention.", "More specifically, the mirror element 20 and the light guide plate 31 in front of the mirror element 20 are stacked so that the respective panel-like surfaces are parallel.", "In other words, the mirror element 20 is a thin panel-like component provided a transmissive portion 20b, a front surface 20a in front of the transmissive portion 20b, and a reflective layer 20c behind the transmissive portion 20b.", "Light enters the mirror element 20 through the front surface 20a, passes through the transmissive portion 20b and reflects from the reflective layer 20c toward the front surface 20a.", "The light guide plate 31 is stacked at the front surface 20a of the mirror element 20.The optical functions of a second embodiment of the present invention thusly configured are described.", "FIG.", "11 is a schematic view illustrating the optical path through the light emitting device 3 in a vehicle display device according to the second embodiment of the present invention.", "FIG.", "11 superimposes a solid arrow and a double-line arrow over a schematic cross-sectional view of the light emitting device 3 according to the second embodiment; here, the solid arrow represents the optical path of light emitted from the light source 30, while the double-line arrow represent the path of external light entering from outside.", "Light emitted from the light source 30 enters the light guide plate 31 from the incidence end surface 32.The light guide plate 31 guides the incident light entering from the light source 30 so that the light is repeatedly totally reflected between the emission surface 33 and the rear surface 34; the light is reflected from the optical-path changing portions 35 (omitted from FIG.", "11), and exits from the emission surface 33.Light exiting the light guide plate 31 from the emission surface 33 exits from the door mirror 2.Note that light exiting the light guide plate 31 from the emission surface 33 does not need to pass through the reflective layer 20c of the mirror component 20; therefore, this allows the light emitting device 3 according to the second embodiment to emit bright light externally.", "The mirror element 20 functions as a mirror by allowing the external light transmitted through the light guide plate 31 to enter through the front surface 20a, pass through the transmissive portion 20b and reflect from the reflective layer 20c to pass through the light guide plate 31 and exit to the outside.", "The external lights reflected by the mirror element 20 is transmitted through the light guide plate 31.However, the surface area of the reflection surfaces 35a of the optical-path changing portions 35 (i.e., the number of reflection surfaces 35a) may be smaller than the surface area of the front surface 20a.", "This configuration allows the mirror element 20 to function as a mirror and additionally keep the distortion of an image reflected there from at a level unrecognizable to an observer.", "The second embodiment, thusly configured may be adopted in a vehicle display device with a light emitting device 3 therein to serve as a door mirror 2.The light emitting device 3 in the vehicle display device (door mirror 2) includes a light source 30 and a light guide plate 31.The vehicle display device functions identically to an ordinary mirror in a door mirror 2 when a driver in the driver seat views the door mirror 2.Outside the vehicle 1, for instance when viewed from a vehicle behind the vehicle 1, the entire mirror surface of the vehicle display device functions as a light emitting device 3 capable of emitting light, and the emission of light may provide various alerts on the operation of the vehicle, e.g., indicating the direction of the vehicle and the like.", "The light guide plate 31 housed in the door mirror 2 is arranged in front of the mirror element 20 and thus also allows a brighter light to be emitted therefrom.", "Third Embodiment The third embodiment uses the light guide plate 31 of the light emitting device 3 as a mirror element 20 in the vehicle display device of the first embodiment.", "Given that only the light guide plate 31 and the mirror element 20 changes in the third embodiment and all other configurations are identical to the first embodiment, it is sufficient to reference the first embodiment for these configurations as further descriptions thereof are omitted.", "The identical parts in the first and third embodiments are given the same reference numerals.", "FIG.", "12 is a schematic view illustrating the optical path through a light emitting device 3 in a vehicle display device according to a third embodiment of the present invention.", "FIG.", "12 superimposes a solid arrow and a double-line arrow over a schematic cross-sectional view of the light emitting device 3 according to the third embodiment; here, the solid arrow represents the optical path of light emitted from the light source 30, while the double-line arrow represent the path of external light entering from outside.", "In the third embodiment the light guide plate 31 with attached light source 30 is inserted into the fastener frame 24 which is secured to the front surface of the drive mechanism 22 that is in the housing 21.The light guide plate 31 also acts as a mirror element; and no specific mirror element 20 is provided.", "A metal-plated or vapor-deposited reflective layer 36 may be formed as a metal-plated or vapor-deposited layer produced on the rear surface of the light guide plate 31 in the vehicle display device according to the third embodiment of the present invention by plating or depositing a metal such as aluminum or silver.", "Therefore, the external light which enters from the emission surface 33 reflects from the reflective layer 36 whereby the light guide plate 31 acts as a mirror element.", "Light emitted from the light source 30 enters the light guide plate 31 from the incidence end surface 32.The light guide plate 31 guides the incident light entering from the light source 30 so that the light is repeatedly totally reflected between the emission surface 33 and the rear surface 34; the light is reflected from the optical-path changing portions 35 and exits from the emission surface 33.Light exiting the light guide plate 31 from the emission surface 33 exits from the door mirror 2.In other words, the light guide plate 31 in the light emitting device 3 possesses an emission surface 33 and optical-path changing portions 35; the emission surface 33 outputs incident light that entered from the light source 30, and the optical-path changing portions 35 change the path of incident light from the light source 30 toward the emission surface 33.The light guide plate 31 further includes a reflective layer 36 formed on the rear surface 34 thereof which faces the emission surface 33; external light entering the light guide plate 31 from the emission surface 33 reflects from the reflective layer 36 toward the emission surface 33.Thus, the light guide plate 31 functions to emit light to outside of the vehicle 1 and as a mirror.", "Note that the light exiting the light guide plate 31 from the emission surface 33 does not need to pass through the mirror element 20 as with the second embodiment; therefore, this allows the light emitting device 3 according to the third embodiment to emit bright light externally.", "The third embodiment, thusly configured may be adopted in a vehicle display device with a light emitting device 3 therein to serve as a door mirror 2.The light emitting device 3 in the vehicle display device (door mirror 2) includes a light source 30 and a light guide plate 31.The vehicle display device functions identically to an ordinary mirror in a door mirror 2 when a driver in the driver seat views the door mirror 2.Outside the vehicle 1, for instance when viewed from a vehicle behind the vehicle 1, the entire mirror surface of the vehicle display device functions as a light emitting device 3 capable of emitting light, and the emission of light may provide various alerts on the operation of the vehicle, e.g., indicating the direction of the vehicle and the like.", "Additionally, having the light guide plate 31 include a reflective layer 36 that acts as the mirror element 20 therefore allows the light guide plate 31 emit bright light.", "Fourth Embodiment The fourth embodiment provides a layer for protecting an outer surface of the light guide plate 31 of the third embodiment.", "Given that only a layer is added in the fourth embodiment and all other configurations are identical to the third embodiment, it is sufficient to reference the third embodiment for these configurations as further descriptions thereof are omitted.", "The identical parts in the third and fourth embodiments are given the same reference numerals.", "FIG.", "13 is a schematic view illustrating the optical path through a light emitting device in a vehicle display device according to a fourth embodiment of the present invention.", "FIG.", "13 superimposes a solid arrow over a schematic cross-sectional view of the light emitting device 3 according to the fourth embodiment; here, the solid arrow represents the optical path of light emitted from the light source 30.In the fourth embodiment the light guide plate 31 with attached light source 30, is inserted into the fastener frame 24 that is secured to the front surface of the drive mechanism 22 in the housing 21.The light guide plate 31 also acts as a mirror element; and no specific mirror element 20 is provided.", "A layer is formed on a surface behind the attached light guide plate 31 to protect the surface at the back of the light guide plate.", "The layer is produced from stacking metal-plated or vapor deposited reflective layer 36 formed by metal plating or vapor-depositing a metal such as aluminum or silver on top of a transmissive layer 37 produced from a resin material such as a transparent polycarbonate resin or a poly methyl methacrylate resin.", "The transmissive layer 37 is integrally molded via heat treatment or the like to the flat portions of the light guide plate 31 with no light focusing portions 35.In a light guide plate 31 thusly configured, the protective layer which includes the transmissive layer 37 and the reflective layer 36, functions as a mirror element since the external light that enters from the emission surface 33 passes through the light guide plate 31, further passes through the transmissive layer 37 and reflects from the reflective layer 36.Light emitted from the light source 30 enters the light guide plate 31 from the incidence end surface 32.The light guide plate 31 guides the incident light entering from the light source 30 so that the light is repeatedly totally reflected between the emission surface 33 and the rear surface 34; the light is reflected from the optical-path changing portions 35 and exits from the emission surface 33.Light exiting the light guide plate 31 from the emission surface 33 exits from the door mirror 2.In other words, the light guide plate 31 in the light emitting device 3 possesses an emission surface 33 and optical-path changing portions 35; the emission surface 33 outputs incident light that entered from the light source 30, and the optical-path changing portions 35 change the path of incident light from the light source 30 toward the emission surface 33.Thus, the light guide plate 31 functions to emit light to outside of the vehicle 1 when the light source 30 emits light, and as a mirror.", "Note that the light exiting the light guide plate 31 from the emission surface 33 does not need to pass through the mirror element 20; therefore, this allows the light emitting device 3 according to the fourth embodiment to emit bright light externally.", "Moreover, the light guide plate 31 is not affected by the reflective layer 36 since no reflective layer 36 is formed at the notched portions in the rear surface 34 of the light guide plate 31 that create the optical-path changing portions 35; consequently, a light emitting device 3 according to the embodiment can present an even brighter image than the display device 1 of the third embodiment.", "The fourth embodiment, thusly configured may be adopted in a vehicle display device with a light emitting device 3 therein to serve as a door mirror 2.The light emitting device 3 in the vehicle display device (door mirror 2) includes a light source 30 and a light guide plate 31.The light guide plate 31 includes a transmissive layer 37 on the rear surface 14 at the rear part facing the emission surface 33, and a reflective layer 36.The transmissive layer 37 allows external light entering from the emission surface 33 of the light guide plate 31 to pass therethrough, and the reflective layer 36 reflects the external light that passed through the transmissive layer 37 toward the emission surface 33.The external light that reflects from the reflective layer 36 passes through the transmissive layer, and exits through the emission surface 33 of the front light guide plate 31.The transmissive layer thus acts as a mirror.", "Fifth Embodiment In the fifth embodiment a vehicle display device according to the present invention is applied to a vehicle window pane.", "The identical parts in the first and fifth embodiments are given the same reference numerals.", "FIG.", "14A, FIG.", "14B, and FIG.", "14C are schematic diagrams for describing an example where a vehicle display device according to the fifth embodiment of the present invention is applied to a vehicle window pane.", "FIG.", "14A illustrates when the light emitting device 3 in the vehicle display device is not emitting light; and FIG.", "14B and FIG.", "14C illustrate when the light emitting device 3 in the vehicle display device emits light.", "The vehicle display device illustrated in FIG.", "14A, FIG.", "14B, and FIG.", "14C is a vehicle window pane, and more specifically is a rear side window 4 in the vehicle 1.The vehicle display device functions as an ordinary window pane (FIG.", "14A) when the light emitting device 3 therein does not emit light.", "The light emitting device 3 emits light whereby, the vehicle display device operates to provide alerts for the various operations of the vehicle such as a direction indicator (FIG.", "14B).", "Additionally, for instance, the vehicle display device may show at least one of an arrow or textual information indicating a lane change (FIG.", "14C) as a means of providing alerts to outside the vehicle for the various operations of the vehicle such as a direction indicator.", "Note that the display of symbol information such as an arrow, or information of a desired fomi such as text may be achieved by appropriately designing the locations at which the optical-path changing portions 35 are formed in the light guide plate 31 as well as the direction toward which incident light is reflected from the light guide plate 31.FIG.", "15 is a schematic diagram for describing an example where a vehicle display device according to the fifth embodiment of the present invention is applied to a vehicle window pane.", "FIG.", "15 illustrates an example of modifying the configuration depicted in FIGS.", "14A, 14B, and 14C; here, the vehicle display device is applied to the rear window 5 of the vehicle 1 to show a symbol modeled after the triangular display panel used for indicating an emergency stop.", "In this manner, the vehicle display device according to the fifth embodiment may be developed for use in various forms.", "FIG.", "16 is a schematic view illustrating the optical path through a light emitting device 3 in a vehicle display device according to a fifth embodiment of the present invention.", "FIG.", "16 superimposes a solid arrow and double-line arrows over a schematic cross-sectional view of the light emitting device 3 according to the fifth embodiment; here, the solid arrow represents the optical path of light emitted from the light source 30, while the double-line arrows from top to bottom and from bottom to top represent the path of light from inside to outside the vehicle, and light from outside to inside the vehicle respectively.", "The light guide plate 31 in the light emitting device 3 is stacked on the cabin facing side (top, FIG.", "16) of the window material 40 used as the window panes for the rear side window 4, the rear window 5, and the like.", "The light guide plate 31 guides the incident light entering from the light source 30 so that the light is repeatedly totally reflected between the emission surface 33 and the rear surface 34; the light is reflected from the optical-path changing portions 35 and exits from the emission surface 33.Light exiting the light guide plate 31 from the emission surface 33 passes through the window material 40 and is emitted outside the vehicle.", "The window material 40 allows light to pass from outside to inside and from inside to outside the vehicle.", "The fifth embodiment, thusly configured may be adopted in a vehicle display device with a light emitting device 3 therein to serve as a window pane such as a rear side window 4, a rear window 5, or the like.", "The light emitting device 3 in the vehicle display device (rear side window 4 and rear window 5) includes a light source 30 and a light guide plate 31.The window material 40 is stacked on the light guide plate 31 toward the outside of the vehicle.", "The rear side window 4 and the rear window 5 function as ordinary windowpanes when the light source 30 does not emit light, and when the light source 30 emits light operates to provide alerts for the various operations of the vehicle such as a direction indicator.", "Sixth Embodiment The sixth embodiment changes the locations of the light guide plate 31 and the window material 40 in the vehicle display device of the fifth embodiment.", "Given that only the location of the light guide plate 31 and the window material 40 changes in the sixth embodiment and all other configurations are identical to the fifth embodiment, it is sufficient to reference the fifth embodiment for these configurations as further descriptions thereof are omitted.", "The identical parts in the first and sixth embodiments are given the same reference numerals.", "FIG.", "17 is a schematic view illustrating the optical path through a light emitting device 3 in a vehicle display device according to a sixth embodiment of the present invention.", "FIG.", "17 superimposes a solid arrow and double-line arrows over a schematic cross-sectional view of the light emitting device 3 according to the sixth embodiment; here, the solid arrow represents the optical path of light emitted from the light source 30, while the double-line arrows from top to bottom and from bottom to top represent the path of light from inside to outside the vehicle, and light from outside to inside the vehicle respectively.", "The light guide plate 31 in the light emitting device 3 is stacked on the window material 40 used as the window panes for the rear side window 4, the rear window 5, and the like toward the outside of the vehicle.", "The light guide plate 31 guides the incident light entering from the light source 30 so that the light is repeatedly totally reflected between the emission surface 33 and the rear surface 34; the light is reflected from the optical-path changing portions 35 and exits from the emission surface 33.The window material 40 allows light to pass from outside to inside and from inside to outside the vehicle.", "The sixth embodiment, thusly configured may be adopted in a vehicle display device with a light emitting device 3 therein to serve as a window pane such as a rear side window 4, a rear window 5, or the like.", "The light emitting device 3 in the vehicle display device (rear side window 4 and rear window 5) includes a light source 30 and a light guide plate 31.The window material 40 is stacked on the light guide plate 31 toward the inside of the vehicle.", "The rear side window 4 and the rear window 5 function as ordinary windowpanes when the light source 30 does not emit light, and when the light source 30 emits light operates to provide alerts for the various operations of the vehicle such as a direction indicator.", "Seventh Embodiment The seventh embodiment uses the light guide plate 31 of the light emitting device 3 as the window material 40 in the vehicle display device of the fifth embodiment.", "Given that only the light guide plate 31 and the window material 40 changes in the seventh embodiment and all other configurations are identical to the fifth embodiment, it is sufficient to reference the fifth embodiment for these configurations as further descriptions thereof are omitted.", "The identical parts in the fifth and seventh embodiments are given the same reference numerals.", "FIG.", "18 is a schematic view illustrating the optical path through a light emitting device 3 in a vehicle display device according to a seventh embodiment of the present invention.", "FIG.", "18 superimposes a solid arrow and double-line arrows over a schematic cross-sectional view of the light emitting device 3 according to the fifth embodiment; here, the solid arrow represents the optical path of light emitted from the light source 30, while the double-line arrows from top to bottom and from bottom to top represent the path of light from inside to outside the vehicle, and light from outside to inside the vehicle respectively.", "Here, the light guide plate 31 in the light emitting device 3 is serves as the window pane for the rear side window 4, the rear window 5, and the like in the seventh embodiment.", "The light guide plate 31 functions as the window material and as a light guide plate, and no specific window material 40 is provided.", "Consequently, while a flexible thin-film material may be sued as the light guide plate 31 in the fifth and sixth embodiments, the light guide plate 31 of the seventh embodiment is produced from a hardened panel like material that is durable enough to serve as a window pane.", "The light guide plate 31 guides the incident light entering from the light source 30 so that the light is repeatedly totally reflected between the emission surface 33 and the rear surface 34; the light is reflected from the optical-path changing portions 35 and exits from the emission surface 33.The light guide plate 31 also allows light to pass from outside to inside and from inside to outside the vehicle.", "The seventh embodiment, thusly configured may be adopted in a vehicle display device with a light emitting device 3 therein to serve as a window pane such as a rear side window 4, a rear window 5, or the like.", "The light emitting device 3 in the vehicle display device (rear side window 4 and rear window 5) includes a light source 30 and a light guide plate 31.The rear side window 4 and the rear window 5 function as ordinary windowpanes when the light source 30 does not emit light, and when the light source 30 emits light operates to provide alerts for the various operations of the vehicle such as a direction indicator.", "The present invention is not limited to the above described embodiments and may be implemented in various other ways.", "Therefore, in all respects the above embodiments are merely examples and should not be interpreted as limitations.", "The scope of the present invention is delineated by the claims and not limited by the specification.", "Moreover, all modifications and variations with a scope equivalent to the claims are within the scope of the present invention.", "For instance, each of the aforementioned embodiments use a single light guide plate 31; the present invention is not limited thereto, and may be developed in various fauns which, for example, use a plurality of light guide plates 31.Moreover, when using a plurality of light guide plates 31, all the light guide plates 31 do not need to be configured to emit light toward outside the vehicle 1.More specifically, the light guide plates 31 that emit light toward outside the vehicle may be stacked, with a light guide plate 31 arranged for emitting light in a direction where the driver is considered the observer.", "The light guide plate 31 designated for the driver as an observer may further include a plurality of light focusing portions configured to change the path of incident light toward the emission surface 33 causing the light output to converge toward a convergence point or convergence line outside the light guide plate or to radiate from a convergence point P or convergence line outside the light guide plate, and thereby form an image externally.", "The vehicle display device thusly configured may be adopted as a door mirror 2.In this case the light guide plate 31 can produce an image from light visible to the driver where the image appears to emerge from a position different from the mirror surface of the door mirror 2.In addition, the basic principles of the door mirror 2 presented in the first through fourth embodiments may be applied to other mirrors such as a rearview mirror.", "Furthermore, the basic principles of the rear side window 4 and the rear window 5 presented in the fifth through seventh embodiments may be applied to other window panes such are the windshield.", "The vehicle display device thusly configured as herein disclosed may be applied to mirrors such as a door mirror 2, and window pane surfaces such as a rear side window 4, a rear window 5, and the like, to provide alerts for the various operations of a vehicle such as a direction indicator, brake signal, emergency signal, and the like to persons outside the vehicle.", "Note that the information that may be provided as an alert is not limited to the vehicles operational state.", "For instance, textual information may be displayed which indicates the state of the roadway being traveled, e.g., “Traffic accident ahead”.", "Hereby, the vehicle display device may be configured to emit light for the purpose of reporting various kinds of information.", "REFERENCE NUMERALS 1 Vehicle 2 Door mirror (vehicle display device) 20 Mirror element 20a Front surface 20b Transmissive portion 20c Reflective layer 3 Light emitting device 30 Light source 31 Light guide plate (light guide element) 32 Incidence end surface 33 Emission surface 34 Rear surface 35 Optical-path changing portion 35a Reflection surface 36 Reflective layer 37 Transmissive layer 4 Rear side window (vehicle display device) 5 Rear windshield (vehicle display device) 40 Window material" ] ]
Patent_15876031
[ [ "DART SCORING SYSTEM", "A platform for facilitating a dart tournament allows gathering, at an electronic bracket program, a master tournament player list for the tournament, which includes the event or events in which each player is participating.", "The platform allows generating, at a cloud server application, a tournament record based on the master tournament player list.", "The platform allows sending of the master tournament player list and the tournament record to mobile computing devices executing an electronic dart scoring application.", "The platform allows scoring a plurality of matches of the tournament on the mobile computing devices executing the electronic dart scoring application.", "The platform allows automatically sending scores in substantially real-time from each of the plurality of matches upon their completion to the cloud server application and electronic bracket program via the one or more application program interfaces; and automatically advancing players at the electronic bracket program based on the sent scores." ], [ "1.An integrated dart scoring platform comprising: an electronic bracket program, a cloud server application, an electronic dart scoring application, and one or more application program interfaces, wherein the platform is configured to facilitate a dart tournament scored on the plurality of mobile computing devices executing the electronic scoring dart application: gathering, at the electronic bracket program, a master tournament player list for the tournament, wherein the master tournament player list includes the event or events in which each player is participating: generating, at the cloud server application, a tournament record based on the master tournament player list; wherein the tournament record comprises at least: device settings, and match rules; sending the master tournament player list and the tournament record to each of the plurality of mobile computing devices executing the electronic scoring dart application; scoring a plurality of matches of the tournament on the plurality of mobile computing devices executing the electronic scoring dart application; automatically sending scores in substantially real-time from each of the plurality of matches upon their completion to the cloud server application and electronic bracket program via the one or more application program interfaces; and automatically advancing players at the electronic bracket program based on the sent scores." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>The game of darts is traditionally an English pub game in which each player takes turns throwing 3 steel-tipped throwing devices (i.e., “darts”) at various targets on a bristle board containing 20 segments and bulls eye.", "The two primary games played in the United States are titled '01 (“oh-one”) and Cricket.", "Historically, scoring was done on chalkboards and more recently, dry erase boards.", "Although electronic wall-mounted score machines have been developed, they can be expensive and many have a steep learning curve.", "Furthermore, electronic soft tip machines use special darts and special scoreboards to automatically record scores when the darts hit the board.", "These are akin to video games, often requiring money for each game and requiring players go to specific establishments having such scoreboards.", "Additionally, dart software programs (i.e., applications) typically have a narrow focus and their interfaces tend to be technical and difficult to learn as they do not conform to the typical chalkboard/dry erase board scoring system.", "Team/league and tournament play is especially challenging to accommodate in such software due to the nature of match format variations and group play.", "Many additional factors have prevented easy-to-use modern scoring systems from being developed and/or widely accepted.", "A first of these is math.", "Scoring a dart game is prone to math errors, which at a minimum slows game play and often results in incorrect scores.", "It is this particular pain point that is credited for giving rise to the soft-tip electronic vending game industry described above, impacting the popularity of the steel tipped game.", "A second factor is the existing electronic scoreboards, which, as stated, can be intimidating or confusing, especially for the uninitiated.", "Confirming and editing recent scores can be very difficult on these systems, due to a lack of instructions.", "Furthermore, interfaces vary dramatically from traditional chalk board scoring.", "A third preventing modern scoring systems from wide acceptance is that darts is a hard game to watch.", "For example, teammates and spectators often struggle with seeing the current score of the match due to legibility, lighting, positioning, and space restrictions.", "This often prevents spectators from keeping up with the status of a live game.", "A fourth problem is finding opponents & creating opportunities to play.", "As with scheduling any joint activity, the logistics of finding an agreeable time and a common meeting point, while managing the personal commitments in life, can make playing darts a challenge.", "A fifth issue are game rule variations.", "There are dozens of niche dart games and practice routines with rule variations.", "The result is that there are hundreds of possibilities of game types, with even identical games going by different names depending on geography.", "This difference creates decreased accuracy.", "Player performance also limits acceptance.", "Players are not familiar with ways to measure their performance as current player performance measurement tools require additional manual calculations after every game or match and is especially tedious for cricket-based games." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>An aspect of the disclosure provides an integrated dart scoring platform comprising an electronic bracket program, a cloud server application, an electronic dart scoring application, and one or more application program interfaces.", "The platform may be configured to facilitate a dart tournament scored on the plurality of mobile computing devices executing the electronic scoring dart application by gathering, at the electronic bracket program, a master tournament player list for the tournament, wherein the master tournament player list includes the event or events in which each player is participating.", "Then, the platform may include, generating, at the cloud server application, a tournament record based on the master tournament player list wherein the tournament record comprises at least device settings and match rules.", "The platform may further comprise, sending the master tournament player list and the tournament record to each of the plurality of mobile computing devices executing the electronic scoring dart application.", "The platform may then comprise scoring a plurality of matches of the tournament on the plurality of mobile computing devices executing the electronic scoring dart application.", "Then the platform may include automatically sending scores in substantially real-time from each of the plurality of matches upon their completion to the cloud server application and electronic bracket program via the one or more application program interfaces; and automatically advancing players at the electronic bracket program based on the sent scores.", "Another aspect of the disclosure provides a method for facilitating a dart tournament.", "The method may include gathering, at an electronic bracket program, a master tournament player list for the tournament, wherein the master tournament player list includes the event or events in which each player is participating.", "Then, the method may include, generating, at a cloud server application, a tournament record based on the master tournament player list wherein the tournament record comprises at least device settings and match rules.", "The method may further comprise, sending the master tournament player list and the tournament record to each of a plurality of mobile computing devices executing an electronic scoring dart application.", "The method may then comprise scoring a plurality of matches of the tournament on the plurality of mobile computing devices executing the electronic scoring dart application.", "Then the method may include automatically sending scores in substantially real-time from each of the plurality of matches upon their completion to the cloud server application and electronic bracket program via the one or more application program interfaces; and automatically advancing players at the electronic bracket program based on the sent scores.", "Yet another aspect of the invention comprises a non-transitory, tangible, computer-readable storage medium, encoded with processor-readable instructions to perform a method of facilitating a dart tournament.", "The method may include gathering, at an electronic bracket program, a master tournament player list for the tournament, wherein the master tournament player list includes the event or events in which each player is participating.", "Then, the method may include, generating, at a cloud server application, a tournament record based on the master tournament player list wherein the tournament record comprises at least device settings and match rules.", "The method may further comprise, sending the master tournament player list and the tournament record to each of a plurality of mobile computing devices executing an electronic scoring dart application.", "The method may then comprise scoring a plurality of matches of the tournament on the plurality of mobile computing devices executing the electronic scoring dart application.", "Then the method may include automatically sending scores in substantially real-time from each of the plurality of matches upon their completion to the cloud server application and electronic bracket program via the one or more application program interfaces; and automatically advancing players at the electronic bracket program based on the sent scores." ], [ "PRIORITY This application is a continuation-in-part of U.S. patent application Ser.", "No.", "14/832,366 filed Aug. 21, 2015 and entitled “Dart Scoring System”, which claims priority to U.S.", "Provisional Application No.", "62/040,299, filed Aug. 21, 2014 and entitled “Dart Scoring System”, which is incorporated herein by reference in its entirety.", "FIELD OF THE INVENTION This invention is related to the game of darts.", "In particular, but not by way of limitation, the invention is related to providing a scoring system for various dart games.", "BACKGROUND OF THE INVENTION The game of darts is traditionally an English pub game in which each player takes turns throwing 3 steel-tipped throwing devices (i.e., “darts”) at various targets on a bristle board containing 20 segments and bulls eye.", "The two primary games played in the United States are titled '01 (“oh-one”) and Cricket.", "Historically, scoring was done on chalkboards and more recently, dry erase boards.", "Although electronic wall-mounted score machines have been developed, they can be expensive and many have a steep learning curve.", "Furthermore, electronic soft tip machines use special darts and special scoreboards to automatically record scores when the darts hit the board.", "These are akin to video games, often requiring money for each game and requiring players go to specific establishments having such scoreboards.", "Additionally, dart software programs (i.e., applications) typically have a narrow focus and their interfaces tend to be technical and difficult to learn as they do not conform to the typical chalkboard/dry erase board scoring system.", "Team/league and tournament play is especially challenging to accommodate in such software due to the nature of match format variations and group play.", "Many additional factors have prevented easy-to-use modern scoring systems from being developed and/or widely accepted.", "A first of these is math.", "Scoring a dart game is prone to math errors, which at a minimum slows game play and often results in incorrect scores.", "It is this particular pain point that is credited for giving rise to the soft-tip electronic vending game industry described above, impacting the popularity of the steel tipped game.", "A second factor is the existing electronic scoreboards, which, as stated, can be intimidating or confusing, especially for the uninitiated.", "Confirming and editing recent scores can be very difficult on these systems, due to a lack of instructions.", "Furthermore, interfaces vary dramatically from traditional chalk board scoring.", "A third preventing modern scoring systems from wide acceptance is that darts is a hard game to watch.", "For example, teammates and spectators often struggle with seeing the current score of the match due to legibility, lighting, positioning, and space restrictions.", "This often prevents spectators from keeping up with the status of a live game.", "A fourth problem is finding opponents & creating opportunities to play.", "As with scheduling any joint activity, the logistics of finding an agreeable time and a common meeting point, while managing the personal commitments in life, can make playing darts a challenge.", "A fifth issue are game rule variations.", "There are dozens of niche dart games and practice routines with rule variations.", "The result is that there are hundreds of possibilities of game types, with even identical games going by different names depending on geography.", "This difference creates decreased accuracy.", "Player performance also limits acceptance.", "Players are not familiar with ways to measure their performance as current player performance measurement tools require additional manual calculations after every game or match and is especially tedious for cricket-based games.", "SUMMARY OF THE INVENTION An aspect of the disclosure provides an integrated dart scoring platform comprising an electronic bracket program, a cloud server application, an electronic dart scoring application, and one or more application program interfaces.", "The platform may be configured to facilitate a dart tournament scored on the plurality of mobile computing devices executing the electronic scoring dart application by gathering, at the electronic bracket program, a master tournament player list for the tournament, wherein the master tournament player list includes the event or events in which each player is participating.", "Then, the platform may include, generating, at the cloud server application, a tournament record based on the master tournament player list wherein the tournament record comprises at least device settings and match rules.", "The platform may further comprise, sending the master tournament player list and the tournament record to each of the plurality of mobile computing devices executing the electronic scoring dart application.", "The platform may then comprise scoring a plurality of matches of the tournament on the plurality of mobile computing devices executing the electronic scoring dart application.", "Then the platform may include automatically sending scores in substantially real-time from each of the plurality of matches upon their completion to the cloud server application and electronic bracket program via the one or more application program interfaces; and automatically advancing players at the electronic bracket program based on the sent scores.", "Another aspect of the disclosure provides a method for facilitating a dart tournament.", "The method may include gathering, at an electronic bracket program, a master tournament player list for the tournament, wherein the master tournament player list includes the event or events in which each player is participating.", "Then, the method may include, generating, at a cloud server application, a tournament record based on the master tournament player list wherein the tournament record comprises at least device settings and match rules.", "The method may further comprise, sending the master tournament player list and the tournament record to each of a plurality of mobile computing devices executing an electronic scoring dart application.", "The method may then comprise scoring a plurality of matches of the tournament on the plurality of mobile computing devices executing the electronic scoring dart application.", "Then the method may include automatically sending scores in substantially real-time from each of the plurality of matches upon their completion to the cloud server application and electronic bracket program via the one or more application program interfaces; and automatically advancing players at the electronic bracket program based on the sent scores.", "Yet another aspect of the invention comprises a non-transitory, tangible, computer-readable storage medium, encoded with processor-readable instructions to perform a method of facilitating a dart tournament.", "The method may include gathering, at an electronic bracket program, a master tournament player list for the tournament, wherein the master tournament player list includes the event or events in which each player is participating.", "Then, the method may include, generating, at a cloud server application, a tournament record based on the master tournament player list wherein the tournament record comprises at least device settings and match rules.", "The method may further comprise, sending the master tournament player list and the tournament record to each of a plurality of mobile computing devices executing an electronic scoring dart application.", "The method may then comprise scoring a plurality of matches of the tournament on the plurality of mobile computing devices executing the electronic scoring dart application.", "Then the method may include automatically sending scores in substantially real-time from each of the plurality of matches upon their completion to the cloud server application and electronic bracket program via the one or more application program interfaces; and automatically advancing players at the electronic bracket program based on the sent scores.", "BRIEF DESCRIPTION OF THE DRAWINGS Various objects and advantages and a more complete understanding of the present invention are apparent and more readily appreciated by reference to the following Detailed Description and to the appended claims when taken in conjunction with the accompanying Drawings wherein: FIG.", "1 depicts a dart game system according to one embodiment of the invention; FIG.", "2A depicts a first screen of a dart gaming system broadcasting feature according to one embodiment of the invention; FIG.", "2B depicts a code screen according to one embodiment of the invention; FIG.", "2C depicts various dart game broadcasting options according to one embodiment of the invention; FIG.", "3 depicts a launch screen according to one embodiment of the invention; FIG.", "4 depicts an '01 scoring interface according to one embodiment of the invention; FIG.", "5A depicts a training tool according to one embodiment of the invention; FIG.", "5B depicts suggested out options in a notification according to one embodiment of the invention; FIG.", "6 depicts an assist notification according to one embodiment of the invention; FIG.", "7 depicts a cricket scoreboard according to one embodiment of the invention; FIG.", "8 depicts a cricket scoreboard according to one embodiment of the invention; FIG.", "9 depicts a cricket scoreboard according to one embodiment of the invention; FIG.", "10 depicts a marksman cricket scoreboard according to one embodiment of the invention; FIG.", "11A depicts a hint that may be provided during cricket play scoreboard according to one embodiment of the invention; FIG.", "11B depicts a hint that may be provided during cricket play scoreboard according to one embodiment of the invention; FIG.", "12 depicts a game and practice generation screen scoreboard according to one embodiment of the invention; FIG.", "12A depicts a game and practice generation screen scoreboard according to one embodiment of the invention; FIG.", "12B depicts a game and practice generation screen scoreboard according to one embodiment of the invention; FIG.", "13 depicts a Group/Team screen according to one embodiment of the invention; FIG.", "14 depicts a Group/Team screen according to one embodiment of the invention; FIG.", "15 depicts a game start screen according to one embodiment of the invention; FIG.", "16 depicts a menu screen according to one embodiment of the invention; FIG.", "17 depicts handicapping and custom scoring screen according to one embodiment of the invention; FIG.", "18 depicts a corking tool according to one embodiment of the invention; FIG.", "19 depicts user settings according to one embodiment of the invention; FIG.", "20 depicts various user interface screens for a dart gaming system according to one embodiment of the invention; FIG.", "21 depicts a match setup screen according to one embodiment of the invention; FIG.", "22 depicts a connection options screen according to one embodiment of the invention; FIG.", "23 depicts a second connection options screen according to one embodiment of the invention; FIG.", "24 depicts a report comprising statistics screen according to one embodiment of the invention; FIG.", "25 depicts a report comprising statistics screen according to one embodiment of the invention; FIG.", "26 depicts a communication according to one embodiment of the invention; FIG.", "27 depicts various statistical leaders according to one embodiment of the invention; FIG.", "28 depicts a diagrammatic representation of one embodiment of a computer system according to one embodiment of the invention; FIG.", "29 depicts a method according to one embodiment of the invention.", "FIG.", "30 depicts a logical block diagram of an integrated dart scoring platform for managing tournaments; FIG.", "31 depicts a settings screen and a match rules screen according to one embodiment of the invention; FIG.", "32 depicts a board selection screen, a selectable match screen, and a match confirmation screen according to one embodiment of the invention; FIG.", "33 depicts an aging board calls screen according to one embodiment of the invention; FIG.", "34 depicts a tournament viewing screen according to one embodiment of the invention; FIG.", "35 depicts a method for implementing a tournament via an integrated dart scoring platform according to one embodiment of the invention; DETAILED DESCRIPTION The dart game system 100 (also referred to herein as a dart scoring system or dart gaming system) seen in FIG.", "1 has addressed the issues presented above.", "For example, the dart gaming system's unique interface substantially decreases the need for math skills and does not interfere with even the most proficient player's game.", "The dart gaming system 100 may also provide a calculation of your three dart average for all games, including a reference point that compares it to your most recent 3 month average.", "The dart gaming system's interface makes it easy to score, confirm or edit what was entered on the prior turn.", "With network access, the dart gaming system's interface can be broadcast to any computing device, allowing spectators who are at a distance or even offsite to follow the score of the game on a public or personal device.", "Furthermore, with network or internet-enabled devices, the dart gaming system 100 allows two opponents in separate locations to play a game, each taking turns scoring their respective turns.", "The dart gaming system 100 also provides a custom play option for enabling various game rules, where users have the ability to design games and practice routines to create the version of the game they are accustomed to playing or want to play.", "One embodiment of the dart scoring system improves game play and the scoring experience.", "For example, the dart gaming system 100 captures data and statistics during the scoring of the game, eliminating the need for manual documentation.", "The dart gaming system 100 further utilizes the cloud to broadcast games for spectators to follow on any internet enabled device and enables game play between 2 opponents in separate locations.", "League and tournament play is supported with instant results & stats available to administrators, captains and players, and an interactive community is created utilizing the data collected from game play.", "It is contemplated that the system 100 may be utilized with or without a network connection.", "For example, when there is a network connection, the system 100 will automatically update the player/league/tournament statistics on a per throw/game/match segment, as identified by the user.", "However, if no network connection is available, the system stores the information locally and transfers the data to the server 180 up re-establishing a network connection, integrating the information with any previous information stored.", "Turning first to FIG.", "1, seen is on embodiment of a dart gaming system 100.Although each figure described below may refer to a particular aspect of the dart gaming system 100, it is contemplated that the figure, or a feature thereof, may be referred to as the system 100.As seen in FIG.", "1, one dart gaming system 100 comprises on-site solutions 110 and off-site solutions 120.The on-site solutions 110 may comprise a scoreboard 112, mobile device 114 or home device 116, while the off-site solutions 120 may comprise one or more network-enabled or internet-enabled devices.", "The off-site solutions 120 may also be referred to herein as remote devices or broadcast devices.", "The use of the system 100 is adapted to provide a quick, easy, and effective dart game scoring mechanism, having the ability to score many niche dart games and/or dart games with one or more regional variation.", "Each of the devices seen in FIG.", "1 may comprise a mobile computing device, a desktop device, or any other computing device known in the art.", "In one embodiment, the scoreboard 112 may be used to enter and display a dart game score on a user interface.", "A server 180 may broadcast the user interface to the remote devices.", "The home devices 116 may mirror the user interface by as a remote device 120.In addition to the scoreboard, 112, the mobile device 114 may also be used to enter scores onto the user interface.", "For example, the scoreboard 112 device may be placed near a dart board.", "In order to enter scores in a safe manner, a player may wish to use his or her handheld mobile device 114 to enter scores into the user interface instead of the scoreboard.", "However, if a mobile device 114 is used to enter scores, the scoreboard 112 may still control various user settings.", "Seen in FIG.", "19 is one set of user settings 1919 that may be controlled by the scoreboard.", "One of these user settings 1919 may comprise when the broadcast scores (i.e., the scores on the remote devices 120) are updated.", "For example, the scores on the broadcast devices may be updated after each dart throw or may be updated after each player, or after each round.", "Other update scenarios are contemplated.", "As seen in FIG.", "1, the remote devices may comprise advertisements—“ADS”, as shown in the figure.", "Turning now to FIG.", "20, seen is a system flow 2095 for enabling various system 100 features.", "For example, the log-in screen 2094 may be initially displayed to a user upon initiating the system 100 on any of the devices seen in FIG.", "1.Through this screen, a user of the dart gaming system 100 may create an active member user profile in the system 100 and access the system 100 features.", "Each active member may have access to all matches & events (e.g., games, tournaments, etc.)", "in which they have participated.", "Data from the games that users have participated in may be populated within a membership account on the server 180, giving each user access to performance analysis.", "Such analysis may be used to provide a user rating and/or a user ranking and/or any other rating/ranking information or metrics which can be used to compare to the user to other members.", "It is also contemplated that the dart gaming system 100 may be used be a guest user 352, as seen in FIG.", "3.A guest user may have the option of subscribing to the system 100 at any point and identifying the games they have previously participated in, populating their membership account with previous game data.", "Additionally, approved “outsiders” (e.g., though leagues, tournaments, etc.)", "can be given permission to have access to selected matches.", "As member games are stored over time, opportunities for virtual game play (i.e., database play) against themselves or others is available.", "After entering a username/password into the log-in screen 2094, the launch screen 2050 may be displayed.", "The launch screen 350 is also seen in FIG.", "3.Upon selecting the play 351 option in the launch screen 350, a menu 2026 screen, as also seen in FIG.", "16 may be displayed.", "Seen in FIG.", "16 are various dart game options 1628.A player may then select one of the dart game options 1628.Upon selecting one of the dart game options 1628, the match set up screen 2045 may be displayed, as seen in FIG.", "20.As seen in FIG.", "21, the match set up screen 2145 may comprise a connect 2131 option, manage player library 2132 option, match format 2133 option, add player 2134 option, and additional options 2136.The match format 2133 option modifies the no of games/sets/matches to be played.", "Players may be added through the add player 2134 and manage player library 2132 options.", "Upon selecting the players in the game, selecting the match format, and any additional options, the connect 2131 option may be selected.", "The connect 2131 option will display the first connection options screen 2060.As seen in FIG.", "22, the connection options screen 2260 may provide a broadcast match option 2261 and an online option 2262.By selecting the broadcast match option 2261, a second connection options screen 2365 may be displayed, as seen in FIG.", "23, which may provide a connection code 2366.The connection codes 2366, 266 described herein may also be referred to as a broadcast key, key, password, or any other similar term known in the art.", "The host may then share this connection code 266, 2366 with other users so that the other users may view the match.", "Turning now to FIGS.", "2A-2C, seen are examples of a dart gaming system broadcasting feature 230.The screen seen in FIG.", "2A may comprise a code option 231, which, when selected, may display the code screen 232 seen in FIG.", "2B.", "Entering the connection code 2366 into this screen will enable the spectator to receive the scoring interface from the scoreboard 112 or other on-site solution 110 device, via the server 180 in at least one embodiment.", "Selecting one of the link options 233 may provide a link to public matches to view.", "For example, the online option 2262 seen in FIG.", "22 may create a publicly-accessible link on a publicly-available webpage.", "This link may have the ability to “broadcast” their match play on the internet—viewable with any browser, when the link is accessed.", "For public broadcasts, interested parties may also be directed to a listing on a web page that provides a link which gives the spectator instant access to the game/match/tournament.", "The broadcasting application may comprise a feature which takes advantage of landscape display environments.", "One dart gaming system 100 may comprise an HTMLS (or any other program known in the art) program capable of running on any computing device comprising an internet browser such as, but not limited to, Internet Explorer®, Mozilla®, or Google Chrome®.", "As seen in FIG.", "2C, a standard viewing option 233, league viewing option 234, and/or game coach viewing option 235 may be provided to a spectator after either entering the code, as seen in FIG.", "2b, or accessing the link through the link options 233.The standard viewing option 233 may display a scoring interface and current averages for each player.", "The league viewing option 234 may also provide a match score and full name listing of the players, while the game coach option 235 may also enable the viewers to receive game tips and strategies.", "The players may also receive these tips and strategies or may choose not to receive them through the user settings 1919, as seen in FIG.", "19.The system 100 may comprise an audio and/or video component (e.g., live two-way audio and video) to any dart game initiated on the dart gaming system.", "Such audio/video may be provided through the dart gaming system using any 3rd-party VOIP or video-streaming service.", "It is contemplated that the video component may be utilized to support the scoring in the system 100.For example, if a score is contested, a video replay may be used to determine whether the entered score was accurate.", "Alternatively, the video feed may be automatically utilized by the system 100 to record scores in the system.", "Two players, geographically separated, can play a match through the dart gaming system 100 by connecting through the server 180.The server 180 will also distribute the user interface on the scoreboard 112 device to the spectators, as well as record and save all player, team, league, and tournament score data for each throw in every game played on the system 100.To enable play between two geographically remote players, a match host may provide the broadcast key to an opponent that the opponent uses to join the host in the system 100.The game may proceed on two devices, giving each player an opportunity to score their own turn.", "The server 180 ensures that each player's scoreboard 112 is updated with the same data in real-time, regardless of which player enters the data.", "The host may also have the option of broadcasting this game to spectators at the same time through the broadcasting feature seen in FIG.", "2 or described in relation to FIGS.", "22 and 23.One embodiment of the system 100 may comprise using data generated by the system 100 to create an interactive community between users of the system.", "In such a community, statistics for players may be created for comparison within and amongst the community.", "Such statistics and reports may be seen in FIGS.", "24 and 25.Furthermore, rankings may be created among friends and/or competitors, players may be allowed to share achievements amongst other users and the system may enable players to play another player's games from a system database.", "For example, users have the ability to practice against “real games” that were previously played by users of the system 100 (themselves or others).", "This feature is provided by the system 100 keeping a historical log of all games played by users of the system.", "In one such feature, the system 100 may select a random recent game previously played by a user.", "Such a game may have been won by the user.", "The system 100 then reproduces each turn the player had, while the challenging player throws live darts and records his turns as he normally would in the system 100.The result is a similar to playing against a computer opponent, but instead the user is alternating turns with a historical game.", "After a match ends, the dart gaming system 100 may generate a communication such as, but not limited to, an email with a link which accesses the reports seen in FIGS.", "24 and 25, or any other report.", "One such communication 2626 is seen in FIG.", "26.An example of statistics 2727 created with the system is shown in FIG.", "27.These reports and/or statistics may comprise information for all match participants and may comprise (a) an event description, (b) a match analysis, (c) a match recap, (d) the recognition of an exceptional player and any team accomplishments, and (e) any other news and/or offers for the user.", "In one embodiment, a user may have the ability to combine match data from separate devices or separate matches into one event summary that the user can review afterwards.", "For multi-device summaries, a user may request an “event key” and then distribute the key to other members of the match who may then flag their matches on their devices with this identifier.", "For a multi-match summary, a user can create an on-going “open” event.", "Anytime a user wants to include a specific match, they would simply reuse the assigned key.", "The dart gaming system 100 is adapted to reduce new user anxiety.", "For example, any required math skills for scoring are eliminated as the system 100 accommodates all level of users.", "This increases the scoring accuracy, using redundant features to mitigate the typical mistakes associated with electronic interfaces, including user miss-keys, score keeper errors and unresponsive devices.", "Furthermore, the system 100 uses traditional scoring methods to replicate the “chalk board” scoring experience, enabling easier, faster and more accurate match scoring, allowing the players and score keepers to focus on the game itself.", "Turning now to FIG.", "4, seen is one example of a scoring screen 490 for an '01 dart game.", "This may be the scoring screen 490 displayed on the scoring device 112 and adapted to receive scoring information, and may be broadcast to the off-site devices 120.Various challenges of scoring a dart match are addressed in such a screen 490.For example, the current turn 492 in the match (i.e., which identifies the user that needs to input a score for each round) is highlighted in s color different from the previously-entered scores in an audit trail 196 to make it clear to all what is being scored.", "Additionally, a score window 494 displays and stores for later review (upon accessing a score in the audit trail 496) what is actually being keyed by the user though an integrated calculator functionality within the keypad, which assists with math processing.", "Through the audit trail 496 of recent turns, players, score keepers and spectators may quickly and easily review the accuracy of entered prior turn scores.", "Also provided is an easy edit “UNDO” button 498 to erase the current entry.", "The UNDO button transforms into a BACK button when there are no entries in the score window 494 and the “BACK” button highlights the prior turn in the audit trail 496 to show parties what was keyed by the user in the score window 494 along with the resulting score in the audit trail 496.Seen in FIG.", "5A is one example of a training tool to assist in determining the optimum targets to win an '01 game.", "As seen, as assist notification 591 may display what score the “Guest” player would need to obtain with each dart in a 3-dart throw in order to obtain a score of “170”.", "These scores are shown as “T20,” “T20,” and “DB,” which means that the first dart throw lands in a triple-20 score portion of the dartboard, the second dart throw also lands on a triple-20 score portion of the dartboard, and the third dart throw lands in the double bull's-eye.", "With each triple-20 score providing sixty points and the double bulls-eye providing 50 points, this point total would be 60+60+50, or 170 points.", "Seen in FIG.", "5B are alternative or additional outputs 593 that may be shown in the notification 591.For example, instead of the alpha-numeric display shown in FIG.", "5A, only a numerical display may be used (though the display in FIG.", "5B does not add up to 170, so this is for a different game/user).", "The alternative output 593 may also provide a “hint” which provides a mathematical solution for reaching the optimum targets.", "In one embodiment, suggested outs for an '01 match may be broadcast to one or more connected devices.", "The devices adapted to receive the suggested outs may be set up through the options 1919, as seen in FIG.", "19.The suggested outs may be based on the current game score.", "For example, the system may utilize a network connection between the scoreboard 112, server 180, and remote devices to broadcast coaching tips to user device in real time or to assist a player with the current game.", "Such messages may be only displayed at an identified user device (e.g.", "the “host” device) and may not be displayed on a shared score board, which may also be referred to herein as a primary score board.", "In addition to the required out strategy for '01 games, additional examples of this feature comprise providing an additional number of point bullseyes required to win a game of Cricket.", "Alternatively, strategy tips may be provided to user for any game.", "As stated, such information may only be broadcast to a particular user, who may request it, which preserves the presentation of the game state on the primary device.", "Turning now to FIG.", "6, seen is an assist notification 691 comprising a suggested out option provided to a user that has thrown a partial turn, but still has one or two darts to throw to complete his round.", "In such an instance, the user may click, for example, the “+” sign in the image below.", "This may display one or more suggested targets for each throw.", "Turning now to FIG.", "7, seen is a cricket scoreboard 705.As seen, the cricket scoreboard 705 uses a “/” or “slash,” an “x,” and an “O” identify a single hit in a single-point throw, a double-point hit in a single throw, and a triple-point hit in a single throw, respectively, on that number.", "The cricket scoreboard 705 also displays the exact throws which lead to three hits “O” mark.", "For example, the “1” bubble shows two slashes (an “x”) and a circle.", "This is used for a user that hit the target over three separate turns.", "The “2” bubble displays a single-slash and a circle, evidencing that a player hit that target once in a prior turn (single slash) then connected again twice in a subsequent turn, with the additional two connections shown by the circle (a double target score portion of the mark was hit, for example).", "If the player hits a valid target three times in the same turn, then the closed target will be represented by a circle only, as seen in bubble “3.” Turning now to FIG.", "8, seen is one example of a cricket scoreboard 805 showing the redundancy in recording scores to ensure accuracy.", "For example, the current turn target “hits” 881 may be highlighted in a first color to differentiate current turn scores (marks) from pre-exiting scores 883 in a second color.", "Additional redundancy may be provided by displaying the number 887 of times a user has tapped the target button 807 for that target (tapping the target button 807 may be how a user identifies that the target was hit by a dart, thereby recording a score for that target).", "This number 887 is shown in FIG.", "8 as the “1” & “4” next to the “18” and “16” targets, respectively.", "Furthermore, any target hit that results in points for the turn, is reflected in the margin for that target (note the “16” points) in the margin for the “16” target.", "Redundancy is further provided by listing all target entries for the turn in the score window 894 (note the “18, 16×4 times”).", "If a target has been “closed” by both players in prior turns (i.e., no further points may be obtained for either player for that target/number), the target may become visibly inactive (e.g., the “20” target button may comprise a darker color).", "Turning now to FIG.", "9, seen is what may happen after a turn has been submitted by pressing the “enter” button, as seen in FIG.", "8.In one embodiment, the cricket scoreboard 905 may display what targets were scored on the previous turn (note the “1” and “4” in the margin).", "Exceptional or high-count turns may generate a pop-up fade-out message 907 calling out the nature of the accomplishment and to ensure the correct score was recorded.", "Seen in FIG.", "10 is a marksman cricket scoreboard 1015.The marksman cricket scoreboard 1015 comprises a 3-button (“D” button, target button, “T” button) approach to scoring cricket.", "The “D” button is for registering a double point score of the proximal Target Number and the “T” button is for registering a triple point score for the proximal Target Number amount.", "The Target Number registers a single target number score.", "This scoreboard 1015 may improve accuracy as the user avoids having to count and tap the Target Number multiple times for each hit that is a double or a triple.", "Furthermore, the score window 1094 displays exactly what was keyed.", "Speed of scoring may be increased since the maximum key stokes per turn is 3, as opposed to up to 9 with the approach seen, for example, in FIG.", "9.Unique statistics may also be provided with the marksman cricket scoreboard 1015.For example, since the user informs the scoreboard 1015 what segment (single/double/triple) of each target the each dart actually hits (as opposed to the “roll up” scoring method associated with the standard FIG.", "9 methods), specific statistics could be generated for this information, including, but not limited to, total missed darts (not just missed turns), total number of triple segments, doubles segments, single segments acquired, and targets hit but not scored due to opponent's existing position in the game.", "Such information may allow the user to know how many darts scored their full potential value or the average of potential value for each dart thrown.", "Turning now to FIGS.", "11A and 11B, seen are hints that may be provided during cricket play.", "In FIG.", "11A the hint is shown in the score window 1194, informing the Host player that the player is behind by 16 points.", "In FIG.", "11B, both players have closed out all their respective targets except the bulls-eye target (“B”).", "Rather than forcing each user to calculate the math value of the number of target bulls that are required for that player to win the game, the system calculates how many bull targets each player needs to hit to win the game.", "As seen in the score window 1194, the host player needs to acquire six Bull targets and the guest player requires only three bull targets to win.", "Turning now to FIG.", "12, seen is a game and practice generation screen 1215.The menu system seen in FIG.", "12 enables a user to design a game or practice routine according to their personal preferences and rules.", "Games and routines fall into 3 general categories: (i) point-style games, (ii) half-it style games, and (iii) target-style games.", "Games & routines can be further customized with options including (a) Enable Negative scoring, (b) Assuming 3 Dart Finish, (c) Determining Target values, (d) Enabling inclusion of Special targets, and (e) Determining the Starting target.", "Created games and routines can be saved for future use.", "FIGS.", "12A and 12B may also be used in creating the new games/practice routines.", "Turning now to FIG.", "13, seen is an example of a Group/Team screen 1325.The Group/Team screen 1325 provides the ability to easily run competing teams of 4-12 players (may have different number of player per team) in a multigame match while also tracking their personal performance and updating their performance statistics in real-time without interfering with match play.", "The Group/Team screen 1325 sets up group play by eliminating traditional menus & software wizards.", "As players are selected for each game through the Edit Teams button, the screen 1325 will automatically change from singles to doubles, triples, etc.", "As seen in FIG.", "13, one Group/Team screen 1325 may be adapted to select two teams for a match and display the team rosters.", "After selecting the players for each team, a match may be initiated by selecting the connect 1331 button.", "The connect button displayed in FIG.", "13 comprises a similar functionality as the connect 2131 option in FIG.", "21 and as seen and/or described elsewhere herein.", "The system 100 may record each player's turn in the order it occurred and automatically start a new set whenever there is a change in the player line-up.", "Through this feature, the system 100 is enabled to create a match summary populated with player names and their throwing order, while tracking individual performance—even when participating in group play (Doubles, Triples, Quadruples).", "The system 100 may inform the players to “Check In” before the next game commences As seen in the Group/Team screen 1425 in FIG.", "14, the players or a third-party score keeper may select the opponents from each team, with the system 100 automatically determining what type of group play is occurring (Doubles in the FIG.", "14 case).", "The system 100 may accommodate team number mismatches such as, but not limited to, Singles vs. Doubles, by automatically recording a “bye” (or miss) for the group that is short a player.", "Alternatively, the system 100 may rotate through each team, ensuring a team member is assigned to each round.", "The system 100 may also provide each opposing team how player data is displayed to the team members.", "For example, a Team Report may display team-related statistical data related to the match, tournament, league, and/or team history.", "A Group Report may provide data for an identified Doubles/Triples/Quads, etc.", "team.", "A Player Report may provide individual darts and accomplishments data, assigned to each player, regardless of whether they are involved in any team or group play.", "Examples of these reports may be seen in FIGS.", "24 & 25.Turning now to FIG.", "15, seen is how to select a starting player.", "After choosing the teams through the edit teams selection, selecting team members from each team to participate in the game from the team lists and connecting, the game start screen 1535 is shown.", "In the game start screen 1535, the selected players are listed and the user selects the play order for each group.", "This is done by touching or selecting each player in each team in the order which they will participate in the match.", "Selecting the player order allows the system 100 to assign the entered dart throw data and corresponding stats and achievements to each individual player, as opposed to a generic “pairing” or group.", "Dart throw data may be entered through one of the screens seen in FIGS.", "4-11B, or any other screen, depending on the dart game being played.", "During group play, the system 100 alternates between opposing teams, listing which player is currently throwing.", "For example, the player name may be listed at the top 1536 of the screen in lieu of, or in addition to, listing the team name.", "The system 100 may also create and provide custom menus for leagues and tournaments to reflect their exact format.", "One benefit of this would be fewer game set-up decisions (game type and options) that need to be made by the score keeper and players.", "When playing an accepted league format, upon launching the system 100 on a mobile computing device, players may be greeted with a simplified menu, such as, but not limited to, the menu 1626 seen in FIG.", "16.Such a menu 1626 would substantially eliminate the need to format each game prior to game start.", "One such menu 1626 may display the league name 1627, acronym and/or logo to reinforce the league brand and assure users they are playing the correct format.", "Also listed are various game options 1628.Looking now at FIG.", "17, seen is a handicapping and custom score chart 1717.Users have the ability with this chart 1717 to modify their starting score to create any custom game or to handicap one of the opponents.", "In one embodiment, prior to starting any game, a user can adjust the starting points, by simply tapping the starting score 1718 in the header.", "The system may allow you to input the starting total (point games) or pre-scored marks (cricket and target games) for either player.", "Users may also have the option of allowing the system to automatically determine the appropriate handicap for a given match up, based on their historical performance.", "One system 100 seen in FIG.", "1 may also comprise a corking tool 1880, as seen in FIG.", "18.Such a tool may be used to determine who throws first in a dart game.", "Prior to game play, each player often throws a single dart at the bulls-eye of a dart board & the player with the closest dart throws first.", "In order to determine who is the closest to the bulls-eye, the corking tool 1880 seen in FIG.", "18 was created.", "The arcs 1881 on the corking tool 1880 are shaped to align with the outer ring on the bulls-eye of a dart board.", "Using the measurement markings 1882 along the edges of the corking tool 1880, a user may determine what distance the dart is located from the outer ring of the bulls-eye, and compare such distance with a distance of another player, potentially playing from a remote location.", "As seen, the measurement markings 1882 are divided up into six lettered sections (A-D), with each lettered section being divided up into six separate numbered sections (1-6).", "The player with the smallest distance to the bull eye would throw first.", "Turning now to FIG.", "29, seen is method 2929 of conducting a dart game.", "The dart game referred to in method 2929 may comprise any of the dart games referred to in any of FIGS.", "1-28 such as, but not limited to, '01 and cricket.", "One method starts at 2909 and at 2919 comprises initiating a dart game in at least one location.", "For example, the location of the scoreboard 112 may comprise such a location.", "At 2939, the method comprises recording a dart player's scores across a plurality of rounds via a user interface on a mobile computing device.", "For example, the user interface may be any of the scoring interfaces described above such as, but not limited to, the '01 interface seen in FIG.", "4 or the cricket interface see in FIG.", "7.At 2949, the method 2929 comprises sharing the user interface and the dart plyer's scores in a near real-time manner with at least one remote location.", "Such a remote location may be the off-site devices 120 seen in FIG.", "1.Although not explicitly listed in FIG.", "29, it is contemplated that the user interface in the method 292 may comprise a first display screen, with the first display screen comprising a game creation option, a game join option, a game share option, and a game watch option.", "For example, and as seen in FIG.", "20 is the launch screen 2050, which may comprise the first display screen.", "Through the launch screen 2050, as use may create a game through the “play” feature (i.e., a game creation option), may join a game through the “connect” 2131 feature (or as otherwise described herein) after selecting any of the league, play, or another other of the options on the screen 2050, and may comprise a game watch option.", "Whatever dart game is chosen may comprise a first dart game.", "One method 2929 may further comprise initiating a second dart game.", "For example, the first and second dart games may be related to a league and/or event/tournament, as seen in FIG.", "20.One or more statistics may be obtained for the first dart game and the second dart game (as well as any additionally-related dart games, as identified by the player in the user settings 1919 or otherwise), aggregating the one or more statistics from the first dart game and the second dart game into a plurality of statistics for the dart player/league/tournament/event, and ranking at least a portion of the plurality of statistics for the dart player against one or more additional dart players/leagues/tournaments/events.", "The method 292 may further comprise providing match summary information to the dart player upon conclusion of the match—for example in a message with a link as shown in FIG.", "26.Game detail information may be provided to the dart player upon conclusion of the match.", "Player performance information may also be provided to at least one of the dart player and the at least one remote location one of during the match and upon conclusion of the match.", "Such information may be seen in FIGS.", "25, 26, as well as FIGS.", "9, 5, and 6.Further methods 292 may comprise storing the dart player's scores related to each of the plurality of rounds in the server 180, choosing to play a game against game stored in the server, and/or utilizing a server device to share the user interface and the dart player's scores in a near real-time manner with at least one additional location.", "Another aspect of the disclosure pertains to systems and methods for integrating the scoring application with systems for managing tournament brackets.", "Some software programs exist for managing the match-ups within sports tournaments, including dart tournaments.", "Such programs may be referred to herein as “electronic bracket programs,” or simply “bracket programs.” The present disclosure provides an electronic bracket program that interacts with the dart scoring application to create a comprehensive electronic tournament scoring and management system.", "The disclosure also provides application program interfaces (APIs) to allow the dart scoring system to integrate with existing electronic bracket programs.", "The APIs of the present dart scoring system provide several features and functions that facilitate the management of dart tournaments.", "Historically, steel tip dart competition has been conducted with a multi-part paper ticket based system, using one part to operate the bracket, one part to accompany the players as they proceed to each match assignment, and the last as proof of event registration.", "Such paper systems are inherently prone to errors and delays, since they are filled out by hand, manually numbered, and continuously change hands between staff and players.", "Sometimes, slips go missing or become duplicated.", "The APIs coordinate an electronic bracket program (including the one provided in the present disclosure and third-party programs) with the connected match scoring system described herein, which provides a level of service to players, spectators and staff that has not previously been available for events and tournaments.", "The APIs enable an electronic bracket program and dart match scoring software to communicate critical information with each other, simplifying the operation of each, reducing event staffing and the need for operational expertise with both programs.", "In addition, the overall system provides players and fans public access to all aspects of the tournaments, so they can locate individual matches, peruse bracket standings, or review results.", "FIG.", "30 shows a logical block diagram of an integrated dart scoring platform 3000 (which may also be referred to as an integrated dart scoring system) for conducting dart tournaments of the present disclosure.", "The diagram should not be construed as a hardware diagram, and may be implemented in software, hardware, or a combination of software and hardware.", "The system 3000 comprises a bracket program 3010.One function of the electronic bracket program 3010 is to provide an interface for collecting player (or team) information, which may be implemented by a Player Information Component 3011.For the purposes of a dart tournament, player information including a player name, player ID (e.g., an ID number assigned to members of sporting associations), and a player e-mail, may be entered upon registration in a particular tournament.", "Bracket programs can generate complete player rosters for a particular event and create an event ID (or competition ID) through an Event ID component 3012.A main function of an electronic bracket program is to create matchups of players out of the roster, based on the competition structure of the tournament, which may be implemented by an Initial Bracket Assignment Component 3013.For example, players on the roster may be placed into a single- or double-elimination competition format, or may be placed into round-robin pool play before being placed in single- or double-elimination rounds.", "Placing players in such brackets manually can be time-consuming and confusing, especially when there are large numbers of players.", "It can be even more time-consuming and confusing to manually advance players into different stages after wins and losses, which is why existing electronic bracket programs create the initial placements and advance players automatically when they win or lose.", "The automatic advancing of players may be implemented by the Bracket Advance Component 3014.The bracket program of the present disclosure provides these functions, but also provides unique features to facilitate the interaction with the dart scoring application.", "Several features of the bracket program of the present disclosure also make it easier to manage tournaments.", "One such feature includes dashboard indicators to create calls to action for a bracket operator.", "Another is a list view of the bracket to provide a simple action list for the bracket operator.", "Yet another is a system for creating a printable mailing label or other small paper document system that expedites the pairing of players and board assignments in the correct initial event board call process to expedite the running of the event.", "This is especially helpful for “Blind Draw” events, which, in a paper based system, require a multi-step process: First, staff must match all the individual player entries with a partner randomly, creating a doubles team.", "Then, staff must then randomly match each doubles team with an additional doubles team.", "Then, the match assignments are organized into a board assignment call order.", "With previous paper-based systems, written entry slips are spread out on a large table to create an initial match of paired teams.", "Then, a secondary match is performed to create the competitions, and then they are organized according to preferred board call assignment.", "The presently disclosed bracket program combines all three steps into one succinct process, that allows a bracket operator to print the board call slips, with the proper partners and opponents in the order they are to be call.", "Printing can occur on cards, full sheets of paper, or mailing labels.", "This feature reduces a 30-minute (or greater) process into an approximately five-minute process.", "Mailing labels allow the staff to reuse the original submitted paper entry slips.", "To utilize a bracket program (either the one of the present disclosure or a third-party bracket program) for a tournament, participants register once for the entire tournament, creating a player record that is aggregated into the Master Player Roster.", "Each player is then eligible to enter into individual event competitions.", "Individual event competition may include, for example, women's only, men's only, one game type only (e.g., either cricket or '01), multiple game types, singles, doubles, etc.", "The Master Player Roster comprises the player information for any player who registers a to play in at least one event throughout the tournament.", "An Event Player Roster (or simply “Event Roster”) is comprises just the player information for players competing in one particular event.", "There may be multiple Event Rosters within a Master Tournament Roster.", "Once a player enters an event through a registration process, the bracket program can either automatically import the eligible players for the event, or the tournament staff can manually enter and/or select participants.", "The bracket program then organizes the competition and provides a dart board assignment for each of the initial match(es) between players.", "In prior approaches, paper tickets would then be used to score the matches and the scores and winners would have to be manually entered in the bracket program, which would typically be run at one, or at most, a few computing devices operated by tournament administrators or staff.", "The integration system of the present disclosure allows the scoring to be done electronically, through computing devices at each board at which a match is being played that execute the dart scoring application of the present disclosure, and transmitted in real time to the bracket program via the cloud server application 3030.The cloud server application 3030 may be the same cloud server application referred to previously throughout this disclosure.", "The bracket program 3010 can then advance players automatically based on the transmitted scores from dart scoring application mobile devices 3050-3052, rather than wait for manual entry of scores and winners.", "The transferring functions between each of the computing devices and applications depicted in FIG.", "30 are performed by one or more APIs, depicted in FIG.", "30 as API 3020.As will be described throughout this disclosure, the API(s) 3020 allows the transfer of information back and forth between the bracket program 3020, cloud server application 3030, and the mobile devices 3050-3052, the control desk(s) 3040, and the remote broadcasting device(s) 3060.As depicted, this information includes, but is not limited to, player registration info 3021, event ID 3022, bracket assignments 3023, board assignments 3024, match scores 3025, notifications 3026, and match progress and status 3027.The integration system 3000 also allows spectators to view scores and tournament standings at one or more remote broadcasting devices 3060 for matches in progress in real-time.", "The present disclosure has previously described how individual matches may be viewed by spectators when broadcast publicly or with a private key; the integration system adds the ability for spectators to view multiple match scores within a tournament and the live tournament standings themselves.", "Additionally, the integrated scoring system 3000 may include a control desk interface 3040, on which certain functions for tournament administrators and staff may be displayed.", "It is contemplated that, in some embodiments, a separate device may not be required to implement the control desk interface 3040, and it may be displayed, instead, on a screen of a device that is running the dart scoring application.", "Still referring to FIG.", "30, to set up a tournament once players have been registered, a bracket program 3000 may first provide player registration information 3021 to the cloud server of the dart scoring application.", "The bracket program sends an Event ID 3022 (also known as a “Competition ID”), and a complete Event Player Roster, which includes at least a Player Name, Player ID, and (optionally, though not required) the Player e-mail of each player on the Event Player Roster.", "Then, the cloud server application, via a Tournament Record Component 3031, develops a Tournament Record, which adds, based on the Event ID, the following information: a Tournament ID (for login purposes) Event Data, Device Settings, Event Format (which provides designations indicating whether the event is Elimination, Round Robin, Set Play, Win by Two, etc.", "), and Match Instructions (which provide actual instructions like Cork for Start, number of legs, alternate, etc.", "), and optionally, a Player ID associated with the scoring application.", "Turning to FIG.", "31, the Device Settings may be visible on a settings screen 3100 of the dart scoring application that show which functions that may be accessible or inaccessible to scorers depending on the Match Rules, as shown on the match rules screen 3150.The device settings screen may highlight what features of the scoring application will be visible during game play and scoring.", "It may be configurable by a scorer, or frozen, depending on the tournament rules.", "Event Match Rules shown on the match rules screen 3150 may include, for example, the eligible games for the match, the starting rules, the number of legs to be played, etc.", "As shown in the match rules screen 3150, the applicable match rules are highlighted and the others are grayed out.", "Depending on the embodiments, scorers may or may not be able to alter these settings.", "Referring back to FIG.", "30, mobile devices 3050-3052 with the dart scoring application may associate with the tournament by logging in (e.g., entering the Event ID on a screen) to the dart scoring application.", "Any device (including the control desk 3040, the mobile application scoring devices 3050-3052, and the remote broadcasting device 3060) associated with the tournament may then receive, from the cloud server application 3030, the Tournament Record 3031, which comprises the complete Event Player Roster 3032, the Event Data 3033, the Device Rules 3033, the Event Match Rules 3035, and any associated Player IDs 3036 (including any player association IDs and scoring-application-specific IDs).", "In some embodiments, only selected information may be sent to each computing device depicted, based on permissions set at the permissions component 3038 at the cloud server application.", "The scoring system is intended to maintain wireless connectivity throughout the competition, so that board assignments, scores, and other information may be transmitted back-and-forth between the scoring devices, the cloud server application, and the bracket program.", "However, several features of the system provide backup and redundancy features to preserve information if network connectivity is lost.", "One of those features is that each device, once logged into the tournament, receives the Tournament Record and Master Tournament Player List and keeps a copy of it locally.", "This feature ensures that, once the device has logged into the tournament, it has at least all the assigned and scheduled matches at the proper boards.", "If, for example, network connectivity is lost after a few matches have been played, and the board assignments are no longer being updated to the device in real-time, the dart scoring application will still be able to pull up a list of correct possible match-ups at particular boards, and may be used to manually select players from the master tournament list if absolutely necessary.", "The Tournament Record 3031 is also transferred from the cloud server application to the bracket program itself through the API 3030.To continue setting up a tournament, the bracket program 3010 may then use this Tournament Record 3031 to create a board assignment for each match.", "Creating a bracket in order to figure out how to advance players and create match-ups is a first component of setting up a tournament; assigning the boards on which those matches are to take place is another endeavor.", "“Boards” may also be referred to as “dart alleys,” and may be identified by numbers.", "For example, the first two players may be assigned to Board 1, the second two players to Board 2, etc.", "In the past, tournament staff set up board assignments manually, which was a very cumbersome and confusing process.", "Some bracket programs have recently developed board assignment tools.", "The bracket program of the present disclosure provides an advanced “intelligent board assignment” system (depicted by component 3015) to further improve the process.", "In general, the process of board assignment in any tournament is accomplished by first creating a list of eligible events.", "Each event can import a player list or be manually populated from the master player list.", "After the bracket program organizes the competition for a specific event, the bracket program creates a Match ID for each individual player vs. player competition, associating it with the Event ID and Tournament ID.", "The final step is assigning a dart alley (board assignment) where the competition will take place.", "The cloud server application electronically notifies participants (for example, via e-mail, text message, push notification, or any other suitable electronic communication) of their board assignment, as well as publishing an electronic master list on viewing screens of the display system (e.g., the dart game display system referred to in FIGS.", "2A-2C).", "One of the fundamental challenges of running a steel tip dart tournament is that there are a limited number of playing fields (dart alleys), with potentially hundreds of players, that are being used by multiple events at the same time.", "Depending on the event format and match rules, the dartboards can turn over every 10-15 minutes.", "No matter what kind of system is used to facilitate a dart tournament, it is the goal of tournament staff to continuously assign as many boards as quickly as possible, without assigning multiple live matches to the same dart alley for certain events.", "In some event formats, though, multiple matches may purposefully be assigned to a single dart alley with the intention that they are to be played sequentially.", "To enable the continual assignment of boards without assigning multiple matches at the same time at the same boards, the bracket program must have a board management system, which is at the tournament level, and not at the individual event level.", "This allows the board management system to manage which boards are currently available (not being actively played on) and to enable tournament staff to develop individual board assignment guidelines for each event.", "For instance, in a singles competition event, staff may want to assign every available board.", "In a team event, staff may choose to assign every other board, or only even/odd boards to allow for additional physical spacing for the multi-player teams (since boards are often placed close together).", "Staff can also designate a range of dart alleys that are eligible for an individual event.", "For example, a particular event may have a board assignment guideline of “even numbered boards only, from 2 to 20,” out of a total of 50 available.", "In prior approaches, assigning boards in this way has been done manually and has been cumbersome to implement.", "These guidelines are typically set before the tournament begins, but may be updated as the tournament continues.", "In embodiments of the disclosure, the event board assignment can either be “absolute” or a “guideline”.", "When it is a guideline, each event bracket operator may view the total list of available dart alleys (those not being currently utilized by an active match from any event).", "However, the preferred dart alleys for the particular event the bracket operator is running may have a primary color designation, while the remaining ones are monochromatic.", "This allows the bracket operator to readily identify recommended boards, yet select any available board, should the need arise.", "In contrast, if an event board assignment is absolute, the designated boards do not appear in the list of boards that other bracket operators can view for their respective events.", "The intelligent board assignment system of the present disclosure (depicted in intelligent board assignment component 3015 of FIG.", "30) enables the assigning of multiple available boards at once.", "This system alleviates a large challenge for tournament management which is made apparent at the start of each event.", "A large event can have more than 50 dart alleys, and it is the goal of tournament staff to facilitate the board assignments as quickly as possible once the initial event draw is done.", "Assigning each board individually creates a time delay that prevents the event from getting underway.", "With a single command, the intelligent board assignment system of the bracket program allows an operator to assign all “available” boards (i.e., ones not being currently utilized), while respecting the board assignment guidelines for that particular event, and any others that are underway.", "The bracket operator has the option of “activating” the board assignments immediately, or setting them to a delay, to both enable additional editing (un-assigning or changing particular board assignments) and to manage when electronic board notifications are sent to the participants.", "Another aspect of the intelligent board management system is that the event operator has the ability to designate which round of the tournament this function should be applied to when they run the command: Preliminary round, Round 1, Round 2, etc.", "For example, a youth event may be set up with an absolute board assignment for boards 1-4 (i.e., all the boards 1-4) for the duration of the youth event, which, for this example, begins sometime after the very start of the tournament and ends sometime before the very end of the tournament.", "These boards will not be listed in any operator's event board list, except for the list of the bracket operator running the youth event.", "This same tournament may begin with a doubles event, for which the staff have set the board assignment guideline to “even numbered” dart alleys.", "Since the doubles event is the first event, there are no boards being utilized yet, the system automatically assigns matches to all available even numbered boards 5-50 in the initial round of competition, because boards 1-4 are not made available for assignment, having been assigned absolutely to the youth event.", "In this same tournament, towards the end of the doubles event, but still during the youth event, a singles competition event begins, and it has a broader board assignment guideline of “all boards,” which means that all boards that are available can be assigned.", "With a single command, all available even and odd boards (including ones that are available despite having been used in the doubles competition earlier) are assigned for the Prelim Round, and then repeated for Round 1 of the singles event with the exception of boards 1-4, which are still assigned to the youth event.", "For the remaining doubles matches, which are now fewer in number, only even numbered dart alleys continue to be recommended and available for the doubles bracket operator to schedule.", "Eventually the youth event ends, and the absolute board guideline for that event is retired, freeing up boards 1-4, for both the doubles and singles events, still respecting their event board guidelines.", "Additional guidelines may be implemented at the tournament level or event level to properly assign boards based on tournament or event rules.", "For example, some tournaments have a rule that a player cannot play on the same board for two consecutive matches because it could potentially give that player an advantage over his or her opponent.", "In order to implement this rule, the intelligent board assignment system may track previously played boards and take those into account in addition to the other event board assignment guidelines.", "In some embodiments, the intelligent board assignment system may have an option of placing a tournament in a full automation mode, rather than having bracket operators assign boards based on guidelines.", "Guidelines could instead be used to automatically assign everything from the initial board assignments to the final event match.", "The results from the scoring application would be used to automatically advance each winner through the bracket and create the board assignments based on bracket assignments.", "The overall integrated scoring system (or platform) may implement several permissions of restriction levels at the various interfaces of the system.", "In general, the scoring application is available to members (i.e., paid subscribers to the scoring application, whether participating in the current tournament or not) and tournament participants.", "The bracket operations, which may be implemented at the control desk 3040, are general only available to tournament staff.", "The dart game display system (e.g., on the remote broadcasting device 3060), is generally available to anyone who wants to watch, including tournament participants, staff, and spectators.", "The display system includes public access to tournament check-in, event registration confirmation (which allows viewing of registrations, but not the function of actually registering), fan alerts, board calls, and live match scores and statuses.", "The live scores and statuses are shown in FIG.", "34, As part of the integration between the bracket program and the scoring application, scorers on devices associated with the tournament may enter a board assignment in a board entry field 3201, as shown in board selection screen 3200 of FIG.", "32.Scorers may be players who self-score in some tournaments, or referees who score in other tournaments.", "Once a board assignment is entered, the scoring application presents only player match-ups that are assigned to that particular board.", "For example, in the match selection screen 3210, only one selectable match 3211 is presented for the scorer to select.", "In some embodiments, this selectable match is also presented based on the time and on previous matches that have been played.", "A “more options” button 3212 is also available, which may allow a scorer to view matches assigned to that particular board for future matches and alternate events.", "In some tournaments, multiple matches may be assigned to the same board at the same time, and the selectable match screen 3211 may present the matches in the recommended order of play to maximize efficiency.", "This selectable match screen 3211 is the result of filtering data at the cloud server application and/or the local scoring application.", "Without such filtering, scorers would have to manually check a master tournament list, and possibly a board assignment list and event list to confirm that the correct players are at the correct board.", "In large tournaments, the process of checking such lists can be time-consuming and error-prone, because they may have dozens or hundreds of entries.", "The selectable match screen 3210 presents only the correct possible matches for the selected board, reducing time and mistakes.", "Once a match is selected, a match confirmation screen 3220 may be shown.", "Each of the pieces of data created by the cloud server application enables the tailoring of distinct match instructions for each event to be delivered to each device.", "This, in turn, allows the dart scoring application and cloud server to run multiple overlapping events simultaneously at each individual scoring device.", "That is, event staff and players do not need to intervene manually to change scoring application instructions every time the same device is used for a different event.", "For example, a single tournament may have both cricket and '01 events, and singles and doubles events.", "Some players may be participating in both simultaneously.", "Also, some dart alleys may be used for both events.", "The rules may differ greatly or slightly between events; no matter the degree of change, it can be difficult to keep track of such changes manually or even mentally.", "When a board assignment is entered into the board selection screen 3200, one of the matches on the match selection screen 3210 is selected, and the match is confirmed on a match confirmation screen 3220, the scoring application screens that will be presented to the scorer will automatically have the correct competition records and match rules for the match.", "This ensures that, when players show up to play at an assigned board at a particular time, neither the staff nor players have to worry about interpreting and implementing the match rules for each event, and do not have to go through a tedious process of selecting participants from the master tournament list.", "Another aspect of the dart scoring system and integration with the bracket program is that match results may be reported in substantially real-time to the bracket program via the cloud server application and used to advance the winner.", "When the match is complete, the scoring application utilizes the API to return the competition record, appended with the match score, to the bracket program.", "The bracket program can then be set up in one of two ways.", "A first option is that an electronic notification appears in the bracket program, that the operator manually approves, releasing the board assignment, advancing the winning player and recording the match score.", "The second option is that the notification automatically performs these steps.", "The match result reporting feature allows tournaments to be run more efficiently and with fewer delays, because it eliminates the need to call in or physically walk scores over to a central control area where the bracket program is run.", "It also eliminates the need for waiting for advances and new board assignments from the bracket program to be communicated to a central viewing area or individual dart alleys.", "In any kind of tournament, bracket advances (whether done manually or electronically) are often displayed on some kind of whiteboard or paper on an easel.", "Since the bracket program itself is electronic, it may be displayed on a central screen, but finding an individual match or player on an entire displayed bracket can still be time-consuming in a big tournament.", "Sometimes, board assignments may be verbally broadcast over a PA system, but such announcements are easy to miss.", "In the present integrated dart scoring system, bracket advances and new board assignments are communicated in real-time back to the scoring applications on individual devices.", "They are also communicated electronically to each player via e-mail, text message, and/or push notification.", "It is contemplated that many tournament participants may have the dart scoring application running on their own smartphones, whether they are self-scoring the tournament matches or not, because if they have the application on their smartphones and are logged into the tournament, they can receive a push notification immediately with a new board assignment.", "Players may want to have the application running on their smartphones for other purposes, including watching other match scores and bracket standings in the tournament.", "Other spectator features enabled by the integrated dart scoring system will be described later in this disclosure.", "Other features of the integrated dart scoring system are related to the automated match status reporting feature, and provide additional tournament efficiency benefits.", "A challenge for all tournament events is running on-time.", "In a traditional paper-based environment, the two most common obstacles are players not responding to their verbal board assignments, which delays the start times of scheduled matched, or failing to report the winning result, which delays the next match assignment.", "Some players who delay reporting winning results do so because they are playing in a high volume of matches, and they may purposefully delay reporting in order to pace themselves and have the matches be a bit more spread out.", "In the present system, the cloud server application automatically time stamps all board assignments, and groups them according their delayed status in 5-minute increments.", "As shown in FIG.", "33, these delayed match starts may be displayed on an “aging board calls” screen 3300.This screen may be visible at a control desk interface of the integrated dart scoring system, and may only be accessible to tournament staff or officials.", "In other embodiments, it may be available to any user of the dart scoring application who is logged into the tournament.", "The aging board calls screen 3300 shows a list in which each line includes a board assignment 3310, a Match ID 3320, and a time-stamp of the board call 3330.Any board calls that have been time-stamped more than five minutes in the past and have not started a match are shown under a 5+ minutes line 3240 and any that have been time-stamped more than 10 minutes in the past are shown under a 10+ minutes line 3250.Other visual cues may be used to alert viewers that matches are running late.", "For example, matches that are more than 15 minutes late may be highlighted in or changed to red.", "This display is enabled by time-stamping bracket advances once they have occurred in the bracket program, sending out board calls to players contemporaneously, and transmitting this information to a computing device that displays the control desk interface.", "This display screen allows staff to police procrastinators and provide the documentation required to disqualify players who are delaying the tournament.", "Tournaments may have rules that disqualify players who are more than 10 minutes late to a board call, for example.", "Some other problems can delay tournaments as well.", "For example, matches may become abandoned or not formally completed due to technical glitches such as devices freezing or running out of batteries, or any number of other unique circumstances.", "FIG.", "34 shows a tournament viewing screen 3400 that may be available on a control desk screen or to any viewer watching the tournament through a viewing mode of the scoring application.", "If matches are abandoned, if they are not formally completed, or should the individual tablet become disconnected to the network, the cloud server application will replace a “live match” icon 3410 with a stop sign icon 3420 to alert tournament staff that a match or device needs to be investigated.", "With the board assignment provided in the match listing, staff can be dispatched to fix the device and/or complete the match, sending results back to the bracket program to free up the board and advance the bracket.", "As discussed previously, there are several features throughout the integrated scoring system that prevent issues resulting from a loss of network connectivity.", "Even if the network fails during the competition, the tournament record (comprising the event list, along with the corresponding match instructions) and the master tournament players list is still stored locally at the mobile computing device, which creates a backup option to score a match.", "Players (or other scorers) can manually select the event and their participant records to create a match.", "The completed match will reside on the individual tablet until the connectivity is restored.", "When a connection is re-established, the scoring application will forward the completed match record(s) to the bracket program via the cloud server application.", "While the record will lack a match ID and board assignment, it will contain a tournament ID, event ID and player IDs, enabling the bracket operator to manually fill in this information and update the results as needed.", "FIG.", "35 shows a method for facilitating a dart tournament using the integrated scoring system of the present disclosure.", "The method may be implemented by an electronic bracket program, a cloud server application, an electronic dart scoring application, and one or more application program interfaces by first, at 3501, gathering, at the electronic bracket program, a master tournament player list for the tournament, wherein the master tournament player list includes the event or events in which each player is participating.", "Then, the method may include, at 3502, generating, at the cloud server application, a tournament record based on the master tournament player list wherein the tournament record comprises at least device settings and match rules.", "The method may further comprise, at 3503, sending the master tournament player list and the tournament record to each of the plurality of mobile computing devices executing the electronic scoring dart application.", "At 3504, the method may comprise scoring a plurality of matches of the tournament on the plurality of mobile computing devices executing the electronic scoring dart application.", "Then at 3505, the method may include automatically sending scores in substantially real-time from each of the plurality of matches upon their completion to the cloud server application and electronic bracket program via the one or more application program interfaces; and at 3506, automatically advancing players at the electronic bracket program based on the sent scores.", "Embodiments of the invention may further comprise a non-transitory, tangible, computer-readable storage medium, encoded with processor-readable instructions to perform a method of providing information related to a dart game.", "One non-transitory, tangible, computer-readable storage medium, encoded with processor-readable instructions may be described with reference to FIG.", "28, below.", "One such method may comprise rendering a dart game scoring interface on a mobile computing device.", "One dart game scoring interface may comprise the various scoring interfaces and display screens shown in the figures and described herein.", "One such interface may display at least one current player score and at least one another player score.", "The method may further comprise ensuring that a dart score is entered correctly into the dart game scoring interface.", "For example, a color of the at least one current player score (the player currently entering scoring data) may be differentiated from the color of the at least one another player's score.", "Additionally, each entry to the scoring interface may be displayed in a scoring interface score window.", "Also, the method may comprise at least one of (i) displaying in an audit trail a sum of each previous entry entered into the score window, and (ii) displaying a number of times a user has selected a target.", "The method may also comprise sharing the dart game scoring interface with a plurality of additional mobile computing devices.", "It is contemplated that a portion of the at least one current player score comprises mark notations, as described herein.", "Furthermore, target on the dart board may comprise one of an enabled target and a disabled target.", "This may occur in a cricket game.", "For example, prior to both or all players hitting the target three times, after a player hits the target three times (receives three mark notations—two slashes and a circle), that player may receive a numerical score for the target amount for any subsequent hits (i.e., “selected” on the user interface) prior to the other player or players hitting the target three times.", "During this period, the target is enabled.", "After all players have hit the target three times, the target is disabled and no points may be obtained for this target by any player.", "The user interface may also comprise a first scoring redundancy and a second scoring redundancy, to ensure scoring accuracy.", "One such first redundancy may comprise differentiating a color of the enabled target from the disabled target.", "A second redundancy may comprise: (i) accessing one sum in the audit trail, (ii) differentiating the color of the accessed sum from each other sum, and (iii) displaying in the score window each previous entry related to the accessed sum.", "The non-transitory tangible computer-readable storage medium method may further comprise requesting an event key, also referred to herein as a code or a password, or any other term known in the art.", "The event key may then be distributed to another computing device and then a dart game scoring interface may be received by another computing device, as well as displaying score information on the interface.", "Such scoring information may be related to one or more forthcoming player dart throws for a next round.", "Such scoring information may be provided before or after the player has thrown at least one dart for the round.", "A fade-out display message may also provide information related to one or more recent dart throws to the plurality of additional mobile computing devices.", "It is contemplated that ensuring that a dart score is entered correctly into the dart game scoring interface further comprises providing a series of selectable features that automatically enter a score related to a dart throw, decreasing a number of selections required to enter the score as compared to the number of selections required not using the series of selectable features, and calculating statistics related to the selectable features.", "The systems and methods described herein can be implemented in a computer system in addition to the specific physical devices described herein.", "Referring back to FIG.", "28, shown is a diagrammatic representation of one embodiment of a computer system 2800 within which a set of instructions can execute for causing a device to perform or execute any one or more of the aspects and/or methodologies of the present disclosure.", "A computer comprising the any of the devices disclosed with reference to FIGS.", "1 and 30, such as, but not limited to, the scoreboard 112 device, the cloud server application 3030, the API 3020, and the bracket program 3010 are examples of some implementations of the computer system 2800.The components in FIG.", "28 are examples only and do not limit the scope of use or functionality of any hardware, software, firmware, embedded logic component, or a combination of two or more such components implementing particular embodiments of this disclosure.", "Some or all of the illustrated components can be part of the computer system 2800.For instance, the computer system 2800 can be a general purpose computer (e.g., a laptop computer) or an embedded logic device (e.g., an FPGA), to name just two non-limiting examples.", "Computer system 2800 includes at least a processor 2801 such as a central processing unit (CPU) or an FPGA to name two non-limiting examples.", "Any of the subsystems described throughout this disclosure could embody the processor 2801.The computer system 2800 may also comprise a memory 2803 and a storage 2808, both communicating with each other, and with other components, via a bus 2840.The bus 2840 may also link a display 2832, one or more input devices 2833 (which may, for example, include a keypad, a keyboard, a mouse, a stylus, etc.", "), one or more output devices 2834, one or more storage devices 2835, and various non-transitory, tangible computer-readable storage media 2836 with each other and with one or more of the processor 2801, the memory 2803, and the storage 2808.All of these elements may interface directly or via one or more interfaces or adaptors to the bus 2840.For instance, the various non-transitory, tangible computer-readable storage media 2836 can interface with the bus 2840 via storage medium interface 2826.Computer system 2800 may have any suitable physical form, including but not limited to one or more integrated circuits (ICs), printed circuit boards (PCBs), mobile handheld devices (such as mobile telephones or PDAs), laptop or notebook computers, distributed computer systems, computing grids, or servers.", "Processor(s) 2801 (or central processing unit(s) (CPU(s))) optionally contains a cache memory unit 2802 for temporary local storage of instructions, data, or computer addresses.", "Processor(s) 2801 are configured to assist in execution of computer-readable instructions stored on at least one non-transitory, tangible computer-readable storage medium.", "Computer system 2800 may provide functionality as a result of the processor(s) 2801 executing software embodied in one or more non-transitory, tangible computer-readable storage media, such as memory 2803, storage 2808, storage devices 2835, and/or storage medium 2836 (e.g., read only memory (ROM)).", "For instance, the methods 2929 in FIG.", "29 may be embodied in one or more non-transitory, tangible computer-readable storage media.", "The non-transitory, tangible computer-readable storage media may store software that implements particular embodiments, such as the method 2929 and processor(s) 2801 may execute the software.", "Memory 2803 may read the software from one or more other non-transitory, tangible computer-readable storage media (such as mass storage device(s) 2835, 2836) or from one or more other sources through a suitable interface, such as network interface 2820.Any of the subsystems herein disclosed could include a network interface such as the network interface 2820.The software may cause processor(s) 2801 to carry out one or more processes or one or more steps of one or more processes described or illustrated herein.", "Carrying out such processes or steps may include defining data structures stored in memory 2803 and modifying the data structures as directed by the software.", "In some embodiments, an FPGA can store instructions for carrying out functionality as described in this disclosure (e.g., the method 2929).", "In other embodiments, firmware includes instructions for carrying out functionality as described in this disclosure (e.g., the method 2929).", "The memory 2803 may include various components (e.g., non-transitory, tangible computer-readable storage media) including, but not limited to, a random access memory component (e.g., RAM 2804) (e.g., a static RAM “SRAM”, a dynamic RAM “DRAM, etc.", "), a read-only component (e.g., ROM 2805), and any combinations thereof.", "ROM 2805 may act to communicate data and instructions unidirectionally to processor(s) 2801, and RAM 2804 may act to communicate data and instructions bidirectionally with processor(s) 2801.ROM 2805 and RAM 2804 may include any suitable non-transitory, tangible computer-readable storage media.", "In some instances, ROM 2805 and RAM 2804 include non-transitory, tangible computer-readable storage media for carrying out the method 2929.In one example, a basic input/output system 2806 (BIOS), including basic routines that help to transfer information between elements within computer system 2800, such as during start-up, may be stored in the memory 2803.Fixed storage 2808 is connected bidirectionally to processor(s) 2801, optionally through storage control unit 2807.Fixed storage 2808 provides additional data storage capacity and may also include any suitable non-transitory, tangible computer-readable media described herein.", "Storage 2808 may be used to store operating system 2809, EXECs 2810 (executables), data 2811, API applications 2812 (application programs), and the like.", "Often, although not always, storage 2808 is a secondary storage medium (such as a hard disk) that is slower than primary storage (e.g., memory 2803).", "Storage 2808 can also include an optical disk drive, a solid-state memory device (e.g., flash-based systems), or a combination of any of the above.", "Information in storage 2808 may, in appropriate cases, be incorporated as virtual memory in memory 2803.In one example, storage device(s) 2835 may be removably interfaced with computer system 2800 (e.g., via an external port connector (not shown)) via a storage device interface 2825.Particularly, storage device(s) 2835 and an associated machine-readable medium may provide nonvolatile and/or volatile storage of machine-readable instructions, data structures, program modules, and/or other data for the computer system 2800.In one example, software may reside, completely or partially, within a machine-readable medium on storage device(s) 2835.In another example, software may reside, completely or partially, within processor(s) 2801.Bus 2840 connects a wide variety of subsystems.", "Herein, reference to a bus may encompass one or more digital signal lines serving a common function, where appropriate.", "Bus 2840 may be any of several types of bus structures including, but not limited to, a memory bus, a memory controller, a peripheral bus, a local bus, and any combinations thereof, using any of a variety of bus architectures.", "As an example, and not by way of limitation, such architectures include an Industry Standard Architecture (ISA) bus, an Enhanced ISA (EISA) bus, a Micro Channel Architecture (MCA) bus, a Video Electronics Standards Association local bus (VLB), a Peripheral Component Interconnect (PCI) bus, a PCI-Express (PCI-X) bus, an Accelerated Graphics Port (AGP) bus, HyperTransport (HTX) bus, serial advanced technology attachment (SATA) bus, and any combinations thereof.", "Computer system 2800 may also include an input device 2833.In one example, a user of computer system 2800 may enter commands and/or other information into computer system 2800 via input device(s) 2833.Examples of an input device(s) 2833 include, but are not limited to, an alpha-numeric input device (e.g., a keyboard), a pointing device (e.g., a mouse or touchpad), a touchpad, a joystick, a gamepad, an audio input device (e.g., a microphone, a voice response system, etc.", "), an optical scanner, a video or still image capture device (e.g., a camera), and any combinations thereof.", "Input device(s) 2833 may be interfaced to bus 2840 via any of a variety of input interfaces 2823 (e.g., input interface 2823) including, but not limited to, serial, parallel, game port, USB, FIREWIRE, THUNDERBOLT, or any combination of the above.", "In particular embodiments, when computer system 2800 is connected to network 2830, computer system 2800 may communicate with other devices, such as mobile devices and enterprise systems, connected to network 2830.Communications to and from computer system 2800 may be sent through network interface 2820.For example, network interface 2820 may receive incoming communications (such as requests or responses from other devices) in the form of one or more packets (such as Internet Protocol (IP) packets) from network 2830, and computer system 2800 may store the incoming communications in memory 2803 for processing.", "Computer system 2800 may similarly store outgoing communications (such as requests or responses to other devices) in the form of one or more packets in memory 2803 and communicated to network 2830 from network interface 2820.Processor(s) 2801 may access these communication packets stored in memory 2803 for processing.", "Examples of the network interface 2820 include, but are not limited to, a network interface card, a modem, and any combination thereof.", "Examples of a network 2830 or network segment 2830 include, but are not limited to, a wide area network (WAN) (e.g., the Internet, an enterprise network), a local area network (LAN) (e.g., a network associated with an office, a building, a campus or other relatively small geographic space), a telephone network, a direct connection between two computing devices, and any combinations thereof.", "A network, such as network 2830, may employ a wired and/or a wireless mode of communication.", "In general, any network topology may be used.", "Information and data can be displayed through a display 2832.Examples of a display 2832 include, but are not limited to, a liquid crystal display (LCD), an organic liquid crystal display (OLED), a cathode ray tube (CRT), a plasma display, and any combinations thereof.", "The display 2832 can interface to the processor(s) 2801, memory 2803, and fixed storage 2808, as well as other devices, such as input device(s) 2833, via the bus 2840.The display 2832 is linked to the bus 2840 via a video interface 2822, and transport of data between the display 2832 and the bus 2840 can be controlled via the graphics control 2821.In addition to a display 2832, computer system 2800 may include one or more other peripheral output devices 2834 including, but not limited to, an audio speaker, a printer, and any combinations thereof.", "Such peripheral output devices may be connected to the bus 2840 via an output interface 2824.Examples of an output interface 2824 include, but are not limited to, a serial port, a parallel connection, a USB port, a FIREWIRE port, a THUNDERBOLT port, and any combinations thereof.", "In addition, or as an alternative, computer system 2800 may provide functionality as a result of logic hardwired or otherwise embodied in a circuit, which may operate in place of or together with software to execute one or more processes or one or more steps of one or more processes described or illustrated herein.", "Reference to software in this disclosure may encompass logic, and reference to logic may encompass software.", "Moreover, reference to a non-transitory, tangible computer-readable medium may encompass a circuit (such as an IC) storing software for execution, a circuit embodying logic for execution, or both, where appropriate.", "The present disclosure encompasses any suitable combination of hardware, software, or both.", "Those of skill in the art will understand that information and signals may be represented using any of a variety of different technologies and techniques.", "Those of skill will further appreciate that the various illustrative logical blocks, modules, circuits, and algorithm steps described in connection with the embodiments disclosed herein may be implemented as electronic hardware, computer software, or combinations of both.", "To clearly illustrate this interchangeability of hardware and software, various illustrative components, blocks, modules, circuits, and steps have been described above generally in terms of their functionality.", "Whether such functionality is implemented as hardware or software depends upon the particular application and design constraints imposed on the overall system.", "Skilled artisans may implement the described functionality in varying ways for each particular application, but such implementation decisions should not be interpreted as causing a departure from the scope of the present disclosure.", "The various illustrative logical blocks, modules, and circuits described in connection with the embodiments disclosed herein may be implemented or performed with a general purpose processor, a digital signal processor (DSP), an application specific integrated circuit (ASIC), a field programmable gate array (FPGA) or other programmable logic device, discrete gate or transistor logic, discrete hardware components, or any combination thereof designed to perform the functions described herein.", "A general purpose processor may be a microprocessor, but in the alternative, the processor may be any conventional processor, controller, microcontroller, or state machine.", "A processor may also be implemented as a combination of computing devices, e.g., a combination of a DSP and a microprocessor, a plurality of microprocessors, one or more microprocessors in conjunction with a DSP core, or any other such configuration.", "The steps of a method or algorithm described in connection with the embodiments disclosed herein (e.g., the method 2929) may be embodied directly in hardware, in a software module executed by a processor, a software module implemented as digital logic devices, or in a combination of these.", "A software module may reside in RAM memory, flash memory, ROM memory, EPROM memory, EEPROM memory, registers, hard disk, a removable disk, a CD-ROM, or any other form of non-transitory, tangible computer-readable storage medium known in the art.", "An exemplary non-transitory, tangible computer-readable storage medium is coupled to the processor such that the processor can read information from, and write information to, the non-transitory, tangible computer-readable storage medium.", "In the alternative, the non-transitory, tangible computer-readable storage medium may be integral to the processor.", "The processor and the non-transitory, tangible computer-readable storage medium may reside in an ASIC.", "The ASIC may reside in a user terminal.", "In the alternative, the processor and the non-transitory, tangible computer-readable storage medium may reside as discrete components in a user terminal.", "In some embodiments, a software module may be implemented as digital logic components such as those in an FPGA once programmed with the software module.", "The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present disclosure.", "Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the disclosure.", "Thus, the present disclosure is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein." ] ]
Patent_15876037
[ [ "ANCHOR BOLT ADAPTOR", "An anchor bolt adapter (ABA) for adapting a bolt circle of an anchor bolt foundation to a bolt circle of a pole is adapted to secure a base to a foundation.", "The ABA can comprise a downwardly positioned female threaded opening configured to receive a first one of the anchor bolts and an upwardly positioned female threaded opening configured to receive a threaded connector bolt." ], [ "1.An anchor bolt adapter (ABA) for adapting a bolt circle of an anchor bolt foundation to a bolt circle of a pole, wherein the foundation includes a plurality of horizontally spaced-apart, upwardly directed anchor bolts having externally threaded upper ends, and the pole including a base portion with a plurality of openings formed therein corresponding to expected positions of the anchor bolts, the adapter comprising: a downwardly positioned female threaded opening configured to receive a first one of the anchor bolts; and an upwardly positioned female threaded opening configured to receive a threaded connector bolt, wherein the upwardly positioned female threaded opening is horizontally spaced apart from the downwardly positioned female threaded opening.", "2.The ABA of claim 1, further comprising an intermediate upwardly or downwardly positioned female threaded opening, horizontally spaced between the downwardly positioned female threaded opening and the upwardly positioned female threaded opening.", "3.The ABA of claim 1, wherein the downwardly positioned female threaded opening extends all the way from an upper surface of the ABA to a lower surface of the ABA.", "4.The ABA of claim 1, wherein a center of the downwardly positioned, female threaded opening is spaced apart from a center of the an upwardly positioned female threaded opening by at least 3 cm.", "5.The ABA of claim 1, wherein the ABA comprises a forged metal alloy.", "6.The ABA of claim 1, wherein the downwardly positioned female threaded opening has a different gauge from the upwardly positioned female threaded opening.", "7.A method of adapting a bolt circle of an anchor bolt foundation to a bolt circle of a pole, comprising: mating a downwardly positioned, female threaded opening of an anchor bolt adapter with an upwardly positioned male threaded anchor bolt having one end anchored into a foundation; and guiding a male threaded member, extending from a body of the anchor bolt adapter, up through a hole in the bolt circle.", "8.The method of claim 7, further comprising mating the upwardly positioned male threaded member with a female threads of a nut, such that at least a portion of the base plate is substantially fixed between a top surface of the anchor bolt adapter and the nut.", "9.The method of claim 7, further comprising guiding the upwardly positioned male threaded member of the anchor bolt through a hole in a second bolt circle.", "10.The method of claim 7, wherein the anchor bolt adapter comprises an upwardly facing female threaded opening, the male threaded member is a bolt, and further comprising the step of mating the bolt with the upwardly facing female threaded opening 11.The method of claim 7, wherein the anchor bolt adapter comprises an upwardly facing female threaded opening, the male threaded member is a bolt, and further comprising guiding the downwardly bolt downwards through a hole in the bolt circle, to mate with the upwardly facing female threaded opening.", "12.The method of claim 7, wherein the downwardly positioned female threaded opening has a different gauge from the male threaded member.", "13.An anchored pole configuration, comprising: a foundation; at least an upwardly directed anchor bolt having one end anchored into the foundation, and an opposite, upwardly extending male threaded end; a pole having a base plate at a lower end, the base plate having a bolt circle; an adapter having a downwardly facing female threaded opening, in mating arrangement with the male threads of the first anchor bolt; and an attachment bolt extending from the adapter through the bolt circle.", "14.The anchored pole configuration of claim 13, wherein the adapter further comprises upwardly facing female threads in mating arrangement with downwardly facing male threads of the attachment bolt.", "15.The anchored pole configuration of claim 13, wherein that attachment bolt has male threads on both ends.", "16.The anchored pole configuration of claim 13, wherein the attachment has a unitary construction with the adapter.", "17.The anchored pole configuration of claim 13, wherein the adapter has a second, downwardly facing female threaded opening.", "18.The anchored pole configuration of claim 13, wherein the downwardly positioned female threaded opening has a different gauge from the attachment bolt." ], [ "<SOH> BACKGROUND <EOH>The background description includes information that may be useful in understanding the present invention.", "It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.", "All publications herein are incorporated by reference to the same extent as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference.", "Where a definition or use of a term in an incorporated reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein applies and the definition of that term in the reference does not apply.", "It is well recognized that light pole and the like foundation anchor bolts do not always match the mounting holes in the base plate of the light pole and the like.", "This can occur for several reasons, including that the anchor bolts were installed incorrectly in the concrete foundation, or that the replacement pole is different from the original.", "In the past this problem has often been addressed by cutting off and then drilling out the existing anchor bolts, followed by epoxying in the new ones.", "Other solutions include demoing the existing footing, and then pouring a new footing with correct location of anchor bolts, modifying the base plate plate, or custom making an adaptor plate.", "All of these solution are problematic from a cost and/or time standpoint.", "Relevant patents and applications include U.S. Pat.", "No.", "3,552,698, US20130036679, U.S. Pat.", "No.", "4,295,308, U.S. Pat.", "No.", "3,837,752, U.S. Pat.", "No.", "3,521,413, U.S. Pat.", "No.", "3,572,223, U.S. Pat.", "No.", "3,630,474, U.S. Pat.", "No.", "4,923,319, U.S. Pat.", "No.", "7,721,490, U.S. Pat.", "No.", "8,037,651, U.S. Pat.", "No.", "8,281,531, US20090272053, and US20100293870.Thus, there remains a need for a system and method that accommodates misaligned anchor bolts and the base plate holes of light or other pole, without having to drill out the existing anchor bolts, or using custom adaptor place." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The following description includes information that may be useful in understanding the present invention.", "It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.", "The inventive subject matter provides apparatus, systems, and methods in which a coupling block is physically positioned between an upwardly positioned anchor bolt and a horizontally disposed base plate.", "The coupling block has at least one downwardly positioned, female threaded opening to receive one of the anchor bolts, and either (a) an upwardly positioned female threaded opening to receive a bolt, or (b) a bolt extending directly upwards out of the body of the coupling block.", "In either case, an upwardly directed bolt has a bottom in the coupling block, whether or not held threadingly in place, passes up through a hole of the base plate, and is secured with a nut positioned above the base plate.", "In light pole installation work, misalignment between anchor bolts and bolt circles/openings can require substantial investments in manpower and monetary resources to correct.", "Conventional anchor bolts are directly anchored into anchor foundations comprising hard materials, such as wood and concrete.", "As a result, misaligned anchor bolts often require the destruction of the anchor foundation.", "It is therefore a principal object of the invention to provide a method and apparatus enabling misaligned anchor bolts to be connected to bolt circles on a light pole.", "A further objective of the invention is to provide positional adjustment options on an anchor bolt adapter to adapt to a variety of bolt circle configurations associated with different base plates.", "Yet another objective of the invention is to provide the ability to adjust the rotational position of a light pole in relation to the anchor bolts.", "Various objects, features, aspects and advantages of the inventive subject matter will become more apparent from the following detailed description of preferred embodiments, along with the accompanying drawing figures in which like numerals represent like components.", "The following discussion provides many example embodiments of the inventive subject matter.", "Although each embodiment represents a single combination of inventive elements, the inventive subject matter is considered to include all possible combinations of the disclosed elements.", "Thus if one embodiment comprises elements A, B, and C, and a second embodiment comprises elements B and D, then the inventive subject matter is also considered to include other remaining combinations of A, B, C, or D, even if not explicitly disclosed." ], [ "Field of the Invention The field of the invention is light poles.", "BACKGROUND The background description includes information that may be useful in understanding the present invention.", "It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.", "All publications herein are incorporated by reference to the same extent as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference.", "Where a definition or use of a term in an incorporated reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein applies and the definition of that term in the reference does not apply.", "It is well recognized that light pole and the like foundation anchor bolts do not always match the mounting holes in the base plate of the light pole and the like.", "This can occur for several reasons, including that the anchor bolts were installed incorrectly in the concrete foundation, or that the replacement pole is different from the original.", "In the past this problem has often been addressed by cutting off and then drilling out the existing anchor bolts, followed by epoxying in the new ones.", "Other solutions include demoing the existing footing, and then pouring a new footing with correct location of anchor bolts, modifying the base plate plate, or custom making an adaptor plate.", "All of these solution are problematic from a cost and/or time standpoint.", "Relevant patents and applications include U.S. Pat.", "No.", "3,552,698, US20130036679, U.S. Pat.", "No.", "4,295,308, U.S. Pat.", "No.", "3,837,752, U.S. Pat.", "No.", "3,521,413, U.S. Pat.", "No.", "3,572,223, U.S. Pat.", "No.", "3,630,474, U.S. Pat.", "No.", "4,923,319, U.S. Pat.", "No.", "7,721,490, U.S. Pat.", "No.", "8,037,651, U.S. Pat.", "No.", "8,281,531, US20090272053, and US20100293870.Thus, there remains a need for a system and method that accommodates misaligned anchor bolts and the base plate holes of light or other pole, without having to drill out the existing anchor bolts, or using custom adaptor place.", "SUMMARY OF THE INVENTION The following description includes information that may be useful in understanding the present invention.", "It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.", "The inventive subject matter provides apparatus, systems, and methods in which a coupling block is physically positioned between an upwardly positioned anchor bolt and a horizontally disposed base plate.", "The coupling block has at least one downwardly positioned, female threaded opening to receive one of the anchor bolts, and either (a) an upwardly positioned female threaded opening to receive a bolt, or (b) a bolt extending directly upwards out of the body of the coupling block.", "In either case, an upwardly directed bolt has a bottom in the coupling block, whether or not held threadingly in place, passes up through a hole of the base plate, and is secured with a nut positioned above the base plate.", "In light pole installation work, misalignment between anchor bolts and bolt circles/openings can require substantial investments in manpower and monetary resources to correct.", "Conventional anchor bolts are directly anchored into anchor foundations comprising hard materials, such as wood and concrete.", "As a result, misaligned anchor bolts often require the destruction of the anchor foundation.", "It is therefore a principal object of the invention to provide a method and apparatus enabling misaligned anchor bolts to be connected to bolt circles on a light pole.", "A further objective of the invention is to provide positional adjustment options on an anchor bolt adapter to adapt to a variety of bolt circle configurations associated with different base plates.", "Yet another objective of the invention is to provide the ability to adjust the rotational position of a light pole in relation to the anchor bolts.", "Various objects, features, aspects and advantages of the inventive subject matter will become more apparent from the following detailed description of preferred embodiments, along with the accompanying drawing figures in which like numerals represent like components.", "The following discussion provides many example embodiments of the inventive subject matter.", "Although each embodiment represents a single combination of inventive elements, the inventive subject matter is considered to include all possible combinations of the disclosed elements.", "Thus if one embodiment comprises elements A, B, and C, and a second embodiment comprises elements B and D, then the inventive subject matter is also considered to include other remaining combinations of A, B, C, or D, even if not explicitly disclosed.", "BRIEF DESCRIPTION OF THE DRAWING FIG.", "1 is a partial view of a pole outfitted with a plurality of inventive Anchor Bolt Adaptors (ABAs).", "FIG.", "2 is a partial section view illustrating the manner in which the Anchor Bolt Adaptor (ABA) of FIG.", "1 is positioned between the anchor bolts and the support plate of the pole.", "FIG.", "3 is a perspective view of the Anchor Bolt Adaptor (ABA) of FIG.", "1.FIG.", "4 is a partial top view of the Anchor Bolt Adaptor (ABA) of FIG.", "1.FIG.", "5 is a top-down perspective view of original bolt circle (anchor bolts) and a modified bolt circle.", "FIG.", "6 is an exploded view of components used to anchor the base plate to the foundation.", "DETAILED DESCRIPTION The inventive subject matter provides apparatus, systems, and methods an anchor bolt adaptor (ABA) has at least one downwardly positioned female threaded opening positioned to mate with an upwardly positioned anchor bolt, and either (a) at least one upwardly positioned female threaded opening positioned to mate with a bolt passing upwards through a base plate, or (b) a bolt extending directly upwards out of the body of the coupling block.", "As used herein the term “bolt” means a shaft having at least one machine-threaded end to which a nut could be secured.", "Also as used herein, the term “threaded end” as applied to a bolt means that the bolt has at least some threads within an inch of an actual end of the bolt.", "Similarly, the term “bolt having one end anchored into the foundation” means a bolt having at least one inch of the actual end of the bolt being anchored, threadingly or non-threadingly, into the foundation.", "FIG.", "1 is a partial view of a pole outfitted with a plurality of ABAs 10 coupled or connected to a pole 12 to a foundation 14 having a plurality of anchor bolts 16 set therein.", "Pole 12 includes a horizontally disposed base plate 20 having a plurality of openings 22 formed therein that do not align with anchor bolt(s) 16.In other words, if footing 14 has 4 anchor bolts set therein a square or rectangle fashion, base plate 20 would have 4 openings 22 formed therein which are arranged in a square or rectangle fashion that does not match that of the anchor bolts 16.Each ABA 10 is mounted respectively on each of anchor bolts 16 using the internally threaded bore 29 that allows each upwardly facing female threaded opening to best align with their respective openings 22.In some embodiments, a washer 17 can be positioned on the upper face of ABA 10.It is also contemplated that ABA 10 of this invention also functions as a leveling nut for the light pole or the like.", "It is further contemplated that the ABA 10 of this invention also functions as a spacer between the top of the foundation and bottom of the pole to allow for water drainage from inside the pole.", "Bolt 36 is mounted to one of the unused threaded bore 29 that best corrects the offset to allow bolt circle 25 on base plate 20 to be secured to anchor bolts 16.Base plate 20 is mounted on the upper ends of the ABA 10 with bolt 36 extended upwards through the openings in washer 17 or not and through opening 22 formed in base plate 20 secured with washer 32 and threadable nut 30.As previously stated, ABA 10 connects the misaligned anchor bolts to base plate 20.FIG.", "2 is a partial section view of one ABA 10 coupled or connected to the base of pole 12 at one end and attached to an anchor bolt 16 at the opposite end.", "As depicted, anchor bolt 16 is screwed into ABA 10 using anchor bolt threads 18.On the opposite end, ABA 10 is removably coupled to base plate 20 of pole 12 through opening 22.FIG.", "3 is a perspective view of one corner of the base of pole 12 and ABA 10 coupled to components allowing ABA 10 to anchor a light pole to a foundation.", "ABA 10 includes an upper end 26, a lower end 28 and two or more internally threaded bores 29 (discussed below in FIG.", "4) extending the distance between the upper and lower ends ABA 10.Anchor bolts 16 can include anchor bolt threads 18 on one end to be mated with the one or more internally threaded bores 29 of ABA 10.FIG.", "4 is a top-down view of ABA 10.ABA 10 includes at least two threaded bores 29.ABA 10 is preferably a rectangular prism shape.", "Threaded bores 29 can have any combination of diameters on the same ABA 10.For example, threaded bores 29 can be different diameters on the same ABA 10.It is also contemplated that threaded bore 29 can receive various adapters to adapt threaded bore 29 to bolts 36 with smaller diameters.", "For example, a threaded bore 29 originally adapted to receive a 1 inch diameter bolt can receive an adapter allowing threaded bore 29 to receive a .75 inch diameter bolt.", "However, ABA 10 can be cube-shaped, ellipsoid-shaped, spherical, and any combination thereof.", "Cross-sections of ABA 10 from the top-down can be rectangular-shaped, oval-shaped, circle-shaped, and any combination thereof.", "FIG.", "5 is a top-down view of pivot circle 24 and bolt circle 25 which defines the maximum reach of ABA 10 and the minimum reach of ABA 10.ABA 10 pivots on a circumference defined by pivot circle 24.The minimum reach of ABA 10 is achieved when 4 ABA 10 are rotated such that the threaded bores 29 that couple with openings 22 are as close together as possible.", "The maximum reach of ABA 10 is achieved when 4 ABA 10 are rotated such that the threaded bores 29 that couple with openings 22 are as far apart as possible.", "It is contemplated that the ABA 10 can be rotated in varying degrees to allow it to anchor to base plates 20 with openings 22 falling between the minimum and maximum reach of ABA 10.FIG.", "6 depicts an exploded view of components comprising the anchoring mechanism.", "Anchor bolts 16 couple with threaded bore 29 of ABA 10 on one side of ABA 10.ABA 10 also couples with bolt 36 on the opposite side of ABA 10 via threaded bore 29.A second end of bolt 36 can be passed through the centers of washer 17, base plate 20 (not depicted), and washer 32 to secure ABA to base plate 20.Threadable nut 30 couples with the second end of bolt 36 to secure base plate 20 to the foundation 14.Thus, it can be seen that a unique ABA has been provided which accomplishes at least all of its stated objectives.", "It should be apparent to those skilled in the art that many more modifications besides those already described are possible without departing from the inventive concepts herein.", "The inventive subject matter, therefore, is not to be restricted except in the scope of the appended claims.", "Moreover, in interpreting both the specification and the claims, all terms should be interpreted in the broadest possible manner consistent with the context.", "In particular, the terms “comprises” and “comprising” should be interpreted as referring to elements, components, or steps in a non-exclusive manner, indicating that the referenced elements, components, or steps may be present, or utilized, or combined with other elements, components, or steps that are not expressly referenced.", "Where the specification claims refers to at least one of something selected from the group consisting of A, B, C .", ".", ".", "and N, the text should be interpreted as requiring only one element from the group, not A plus N, or B plus N, etc." ] ]
Patent_15876042
[ [ "LTE-BASED WIRELESS COMMUNICATION SYSTEM FOR THE M-LMS BAND", "A receiver capable of receiving and a transmitter capable of transmitting LTE (Long-Term Evolution) signals.", "The receiver is capable of executing firmware to determine position location from a received LTE-like position waveform over signals modulated on a carrier in a positioning frequency band.", "In one embodiment the positioning signals are transmitted in a positioning band continuously for up to 100 ms, allowing the receiver to integrate the received positioning signals over a period of up to 100 ms.", "In one such embodiment, the signals can be integrated coherently for up to 60 ms, assuming acceptable stability of the clock in the receiver and further assuming that less than a predetermined amount of Doppler shift has been introduced in the received signal.", "The number of physical resource blocks (PRB) can be determined to optimize the signal allocation for the available bandwidth." ], [ "1.A method for transmitting positioning signals, the method comprising: generating a grid of resource elements, the resource elements within the grid being grouped into physical resource blocks (PRBs); organizing the PRBs in slots, each slot having a number of the PRBs; and transmitting a signal used for positioning in multiple contiguous slots in a continuous transmission at a frequency within a frequency band allocated for determining position.", "2.The method of claim 1, wherein the number of the PRBs is 37 or 40, and each PRB comprises 7×12 resource elements.", "3.The method of claim 1, wherein each resource element represents an allocation of one symbol in time to one LTE OFDM (Orthogonal Frequency Division Multiplexing) sub-carrier in frequency.", "4.The method of claim 1, wherein transmitting the slots includes transmitting the slots in at least 60 consecutive subframes.", "5.The method of claim 1, wherein the frequency band is an M-LMS (Multilateration and Location Monitoring Service) band.", "6.The method of claim 1, further comprising: transmitting a Long Term Evolution (LTE) signal over another frequency allocated by the Federal Communications Commission (FCC) for use by cellular telephones.", "7.A method for receiving positioning signals, the method comprising: generating a grid of resource elements, the resource elements within the grid being grouped into physical resource blocks (PRBs); receiving an Orthogonal Frequency Division Multiplexing (OFDM) modulated positioning signal on a frequency within a frequency band allocated for transmitting positioning signals; and searching for positioning information within the received positioning signal using the parameters of the generated grid of resource elements as search parameters, where multiple resource elements used for the positioning information are contiguous and received after being continuously transmitted.", "8.The method of claim 7, wherein the grid of resource elements includes 37 or 40 PRBs that are grouped together in a slot, and each PRB comprises 7×12 resource elements.", "9.The method of claim 7, wherein each resource element represents an allocation of one symbol in time to one LTE OFDM (Orthogonal Frequency Division Multiplexing) sub-carrier in frequency.", "10.The method of claim 7, wherein searching for position information includes integrating the received signal over at least 60 consecutive subframes.", "11.The method of claim 7, wherein the frequency band is an M-LMS (Multilateration and Location Monitoring Service) band.", "12.A positioning system comprising: a transmitter that includes: a resource element grid generator (REGG) having first and second inputs and an output, the first input coupled to receive a signal indicating a number of physical resource blocks (PRBs) to be included in a generated grid of resource elements, and the second input coupled to receive a signal indicating a number of subframes to be consecutively transmitted by the transmitter; a modulator having a first input and an output, wherein the first input is coupled to the output of the REGG to receive a signal having a number of PRBs together in a slot and the signal having a number of slots to be consecutively transmitted from the transmitter; and a radio frequency (RF) signal generator having a first input coupled to the output of the modulator to receive a modulated waveform from the modulator, the modulated waveform having a number of consecutive slots to be contiguously transmitted in a continuous transmission at a frequency within a frequency band for transmitting a positioning signal.", "13.The system of claim 12, wherein the transmitter further includes: a physical layer (PHY) controller, the PHY controller having a first output coupled to the first input of the REGG to provide the signal indicating the number of physical resource blocks (PRBs) to be included in the generated grid of resource elements, the PHY controller having a second output coupled to the second input of the REGG to provide the signal indicating the number of subframes to be consecutively transmitted by the transmitter, wherein the modulator has a second input coupled to the PHY controller to receive position location content to be modulated on the signal received from resource element grid generator.", "14.The system of claim 12, wherein the RF signal generator has second input to receive information regarding a carrier frequency to be used for transmitting the positioning signal.", "15.The system of claim 12, wherein the received signal indicating the number of PRBs to be included in the generated grid of resource elements indicates that 37 or 40 PRBs are to be included in the generated grid of resource elements, and wherein each PRB comprises 7×12 resource elements.", "16.The system of claim 15, wherein each resource element represents the allocation of one symbol in time to one OFDM sub-carrier in frequency.", "17.The system of claim 12, wherein the received signal indicating the number of subframes to be consecutively transmitted by the transmitter indicates that the number of subframes to be consecutively transmitted is 60.18.The system of claim 12, wherein the frequency band is an M-LMS (Multilateration and Location Monitoring Service) band.", "19.The system of claim 12, the system further comprising: a receiver that includes: a down converter having a first input to receive an Orthogonal Frequency Division Multiplexing (OFDM) modulated positioning signal, the down converter having a second input to receive information regarding a carrier frequency of the received positioning signal; and a searcher having a first input coupled to receive a signal indicating a number of physical resource blocks (PRBs) to be included in a search for position information within the received positioning signal, and having a second input coupled to receive a signal indicating a number of subframes over which the searcher is to integrate the received positioning signal in performing the search for positioning information.", "20.The receiver of claim 19, wherein the received positioning signal comprises a plurality of consecutively transmitted slots, wherein each slot of the received positioning signal having 37 or 40 PRBs, wherein the signal indicating the number of PRBs indicates that there are 37 or 40 PRBs in each slot of the received positioning signal, and wherein each PRB comprises 7×12 resource elements." ], [ "<SOH> BACKGROUND <EOH>Quickly and accurately estimating the location of things within a geographic area can be very useful.", "For example, information regarding the location of people or items can be used to speed up emergency response times, track movement of items and people, and link consumers to nearby businesses.", "Most approaches rely on a process called trilateration.", "Trilateration uses geometry to estimate the position of an object using distances traveled by different positioning signals (also referred to as “ranging” signals) that are transmitted from three or more transmitters to receivers that are co-located with the object to be located.", "Various networks of transmitters have been used to transmit positioning signals.", "For example, orbiting satellites in the Global Positioning Satellite (GPS) system transmit positioning signals.", "Each GPS satellite transmits a positioning signal on which a coarse/acquisition code is modulated.", "The positioning signal is received by a GPS receiver.", "The GPS receiver identifies the time the positioning signal was transmitted by the satellite.", "The receiver also determines a relative time of arrival based on an internal clock in the receiver.", "Once the transmission time and the relative reception times of the positioning signal are known, the receiver uses measurements from at least three satellites to solve a set of simultaneous equations to determine the position and relative clock offset for the receiver.", "Unfortunately, GPS signals are very faint, which means that the signals require integration over a very long time for a receiver to acquire a GPS signal and to demodulate enough information from the signal to determine the range measurements necessary to determine the location of the receiver.", "In many cases, the range measurements are not as accurate as may be desired due to the fact that the signals may take indirect paths from the GPS satellites to the receiver.", "Acquiring enough information to compute an estimated range measurement associated with a direct path from each GPS satellite to the receiver may take additional time and processing power.", "Receiving weak GPS signals in urban environments poses additional problems.", "Weak GPS signals often cannot reach receivers through buildings.", "In addition, in such urban environments, GPS signals are more likely to take multiple paths by reflecting off buildings.", "As noted above, such “multipathing” disrupts a receiver's ability to accurately estimate a range measurement between the receiver and the satellite.", "One way to address the challenges of determining the position location of a device in an urban environment is to use terrestrial transmitter systems.", "Such terrestrial transmitter systems provide stronger signals.", "Furthermore, terrestrial transmitter systems can include transmitters at different locations within the urban environment that reduce the number of instances when there is no direct path between the satellite and the receiver.", "Examples of terrestrial transmitter systems that transmit positioning signals are described in U.S. Pat.", "No.", "8,130,141 (the “'141 patent”).", "In at least one embodiment of the '141 patent, each terrestrial transmitter uses a GPS-like channel to transmit a precisely-timed positioning signal.", "The receiver computes its location by processing the positioning signals from three or more terrestrial transmitters, similar to the way in which the receiver would process GPS positioning signals from three or more GPS satellites.", "Since most (if not all) receivers understand how to process GPS signaling, the signals transmitted by such a terrestrial transmitter system can be used by existing receivers with minimal (or no) modifications to those receivers.", "Even though terrestrial transmitter systems provide a more-reliable positioning service than GPS, such terrestrial transmitter systems may require a substantial amount of additional infrastructure to transmit the terrestrial positioning signals.", "Therefore, it would be desirable to reduce the need for such additional terrestrial hardware.", "In addition to using terrestrial positioning signals transmitted from stations dedicated to sending such positioning signals, cellular telephones are capable of performing ranging measurements, such as observed time difference of arrival (OTDOA) measurements on cellular telephone signals, such as LTE (Long-Term Evolution) signals.", "Such signals are transmitted with waveforms organized in resource blocks.", "Each resource block consists of 7×12 resource elements in the case of normal cyclic prefix.", "In one embodiment in which an extended cyclic prefix is used, a Physical Resource Block (PRB) only has 6 symbols.", "A resource element represents the allocation of one symbol in time to one OFDM (Orthogonal Frequency Division Multiplexing) sub-carrier in frequency.", "A typical LTE waveform is transmitted at a frequency that is different from the frequency of dedicated terrestrial positioning systems, such as systems that conform to the well-known M-LMS industry standard.", "Typical LTE waveforms used to communicate positioning information comprise 50 resource blocks transmitted over a period of 6 ms.", "Accordingly, when determining the time difference of arrival of such LTE signals, the received signal is integrated over a period of no more than 6 ms.", "Restricting the positioning signals to 6 ms reduces the amount of bandwidth consumed by the positioning signals.", "While it is advantageous to use LTE signals for ranging due to the ubiquitous nature of the LTE, there are several deficiencies with using the LTE signals for ranging.", "For one, it would be advantageous to be able to integrate over longer times.", "In addition, it would be advantageous to have waveforms that conform with a format optimized for position location rather than to a cellular telephone format, such as the signals that are transmitted by M-LMS (Multilateration and Location Monitoring Service) systems." ], [ "<SOH> SUMMARY <EOH>Various embodiments described in this disclosure relate generally to methods, systems, means, and machine-readable media for reducing the number of additional terrestrial transmitters required to provide a reliable “position location” system (i.e., a “positioning” system that aids in determining the position of a receiver).", "Such methods, systems, means and machine-readable media may use pre-existing cellular telephone infrastructure to supplement terrestrial transmitter systems for determining the location of a receiver.", "Certain embodiments include a receiver capable of receiving LTE (Long-Term Evolution) signals and capable of executing instructions embodied in firmware, software or the like, in order to determine position location information from a received LTE-like position waveform.", "In one embodiment, positioning signals are transmitted continuously for what is referred to as a “positioning period” of up to 100 ms, allowing the receiver to integrate the received positioning signals over that positioning period.", "The positioning signals can be integrated coherently for up to 60 ms, assuming acceptable stability of a clock in the receiver, and further assuming that less than a predetermined amount of Doppler shift has been introduced in the received signal.", "For integration over a period greater than approximately 60 ms, the integration can be done non-coherently.", "Instructions may be executed by a physical layer controller that controls a radio frequency section (RF) of the receiver.", "Under the control of the firmware, the physical layer controller (i.e., PHY controller) instructs the RF section of the receiver to tune to a center frequency and indicates the number of PRB (physical resource blocks) to be used to generate the waveform.", "The center frequency is outside the LTE band.", "In addition, the number of PRBs (each having a bandwidth of 180 kHz (i.e., 12 sub-carriers multiplied by 15 kHz each) determines the bandwidth of the waveform.", "In one embodiment, the frequency to which the RF section tunes is in the M-LMS (Multilateration and Location Monitoring Service) frequency band.", "The PHY controller also instructs the RF section to receive the signal in accordance with an LTE-like format that has 40 PRBs for a bandwidth of approximately 7.2 MHz.", "The resulting signal is then pulse shaped to constrain the signal to the desired frequency mask.", "In one embodiment, the result of the pulse shaping is a signal having a bandwidth of 8 MHz.", "Alternatively, the LTE-like format has 37 PRBs for a bandwidth of 6.66 MHz which is pulse shaped to fit within a 7.5 MHz mask.", "In one embodiment, an LTE-like format can have other numbers of PRBs, where a PRB is defined according to the LTE standard.", "Each such PRB includes 12 subcarriers, and each sub-carrier has a bandwidth of approximately 15 kHz and extends for a period of 1 ms (i.e., the duration of an LTE subframe).", "A receiver may receive a waveform that includes a number of continuous subframes.", "The PHY controller may instruct the RF section to receive the number of subframes that are included in the waveform.", "In one embodiment, the waveform includes up to 100 or more subframes.", "In another embodiment, the waveform includes 60 subframes and the receiver performs coherent integration on the received signals.", "In yet another embodiment, the waveform includes 200 subframes.", "In yet another embodiment, the waveform includes n subframes, where n is greater than a standard number of subframes.", "The receiver may also decover the signal, including the PRS (position reference signal) samples, integrating them across the predetermined number of subframes to maximize the strength of the decovered positioning signal.", "By using firmware to control the PHY controller, the RF section can be controlled in a way that uses LTE standard PRBs to allow the RF section to generate a new LTE format that is particularly well-suited for generating positioning signals, such as M-LMS signals.", "Thus, the receiver may operate in accordance with the general operation of an LTE receiver, with the only change being to the firmware to instruct the RF section to generate a new waveform having a non-LTE standard number of PRBs at a non-LTE center frequency for a duration that is greater than the LTE waveform.", "A transmitter may be capable of transmitting LTE signals and capable of executing instructions to form LTE-like positioning signals having a duration of greater than 6 ms transmitted at a carrier frequency within a terrestrial positioning system spectrum, such as the spectrum used by M-LMS.", "In one embodiment, the instructions control the operation of a digital signal processor (DSP) within the physical layer of the transmitter.", "In another embodiment, the signals that are transmitted during the positioning period use a different type of modulation that is optimized for the positioning application—e.g., based on direct sequence spread spectrum (DSSS), such as employed in systems currently deployed in the M-LMS band., where LTE-based signals are transmitted at the remaining times.", "Details of embodiments are set forth in the drawings and the description below." ], [ "RELATED APPLICATIONS This application relates to U.S. patent application Ser.", "No.", "62/117,580, filed Feb. 18, 2015, entitled AN LTE-BASED WIRELESS COMMUNICATION SYSTEM FOR THE M-LMS BAND, the content of which is hereby incorporated by reference herein in its entirety.", "This application relates to U.S. patent application Ser.", "No.", "15/015,935, filed Feb. 4, 2016, entitled AN LTE-BASED WIRELESS COMMUNICATION SYSTEM FOR THE M-LMS BAND, the content of which is hereby incorporated by reference herein in its entirety.", "FIELD Various embodiments relate to wireless communications, and more particularly, to transmitting positioning signals over an M-LMS band from an LTE (Long-Term Evolution) base station.", "BACKGROUND Quickly and accurately estimating the location of things within a geographic area can be very useful.", "For example, information regarding the location of people or items can be used to speed up emergency response times, track movement of items and people, and link consumers to nearby businesses.", "Most approaches rely on a process called trilateration.", "Trilateration uses geometry to estimate the position of an object using distances traveled by different positioning signals (also referred to as “ranging” signals) that are transmitted from three or more transmitters to receivers that are co-located with the object to be located.", "Various networks of transmitters have been used to transmit positioning signals.", "For example, orbiting satellites in the Global Positioning Satellite (GPS) system transmit positioning signals.", "Each GPS satellite transmits a positioning signal on which a coarse/acquisition code is modulated.", "The positioning signal is received by a GPS receiver.", "The GPS receiver identifies the time the positioning signal was transmitted by the satellite.", "The receiver also determines a relative time of arrival based on an internal clock in the receiver.", "Once the transmission time and the relative reception times of the positioning signal are known, the receiver uses measurements from at least three satellites to solve a set of simultaneous equations to determine the position and relative clock offset for the receiver.", "Unfortunately, GPS signals are very faint, which means that the signals require integration over a very long time for a receiver to acquire a GPS signal and to demodulate enough information from the signal to determine the range measurements necessary to determine the location of the receiver.", "In many cases, the range measurements are not as accurate as may be desired due to the fact that the signals may take indirect paths from the GPS satellites to the receiver.", "Acquiring enough information to compute an estimated range measurement associated with a direct path from each GPS satellite to the receiver may take additional time and processing power.", "Receiving weak GPS signals in urban environments poses additional problems.", "Weak GPS signals often cannot reach receivers through buildings.", "In addition, in such urban environments, GPS signals are more likely to take multiple paths by reflecting off buildings.", "As noted above, such “multipathing” disrupts a receiver's ability to accurately estimate a range measurement between the receiver and the satellite.", "One way to address the challenges of determining the position location of a device in an urban environment is to use terrestrial transmitter systems.", "Such terrestrial transmitter systems provide stronger signals.", "Furthermore, terrestrial transmitter systems can include transmitters at different locations within the urban environment that reduce the number of instances when there is no direct path between the satellite and the receiver.", "Examples of terrestrial transmitter systems that transmit positioning signals are described in U.S. Pat.", "No.", "8,130,141 (the “'141 patent”).", "In at least one embodiment of the '141 patent, each terrestrial transmitter uses a GPS-like channel to transmit a precisely-timed positioning signal.", "The receiver computes its location by processing the positioning signals from three or more terrestrial transmitters, similar to the way in which the receiver would process GPS positioning signals from three or more GPS satellites.", "Since most (if not all) receivers understand how to process GPS signaling, the signals transmitted by such a terrestrial transmitter system can be used by existing receivers with minimal (or no) modifications to those receivers.", "Even though terrestrial transmitter systems provide a more-reliable positioning service than GPS, such terrestrial transmitter systems may require a substantial amount of additional infrastructure to transmit the terrestrial positioning signals.", "Therefore, it would be desirable to reduce the need for such additional terrestrial hardware.", "In addition to using terrestrial positioning signals transmitted from stations dedicated to sending such positioning signals, cellular telephones are capable of performing ranging measurements, such as observed time difference of arrival (OTDOA) measurements on cellular telephone signals, such as LTE (Long-Term Evolution) signals.", "Such signals are transmitted with waveforms organized in resource blocks.", "Each resource block consists of 7×12 resource elements in the case of normal cyclic prefix.", "In one embodiment in which an extended cyclic prefix is used, a Physical Resource Block (PRB) only has 6 symbols.", "A resource element represents the allocation of one symbol in time to one OFDM (Orthogonal Frequency Division Multiplexing) sub-carrier in frequency.", "A typical LTE waveform is transmitted at a frequency that is different from the frequency of dedicated terrestrial positioning systems, such as systems that conform to the well-known M-LMS industry standard.", "Typical LTE waveforms used to communicate positioning information comprise 50 resource blocks transmitted over a period of 6 ms.", "Accordingly, when determining the time difference of arrival of such LTE signals, the received signal is integrated over a period of no more than 6 ms.", "Restricting the positioning signals to 6 ms reduces the amount of bandwidth consumed by the positioning signals.", "While it is advantageous to use LTE signals for ranging due to the ubiquitous nature of the LTE, there are several deficiencies with using the LTE signals for ranging.", "For one, it would be advantageous to be able to integrate over longer times.", "In addition, it would be advantageous to have waveforms that conform with a format optimized for position location rather than to a cellular telephone format, such as the signals that are transmitted by M-LMS (Multilateration and Location Monitoring Service) systems.", "SUMMARY Various embodiments described in this disclosure relate generally to methods, systems, means, and machine-readable media for reducing the number of additional terrestrial transmitters required to provide a reliable “position location” system (i.e., a “positioning” system that aids in determining the position of a receiver).", "Such methods, systems, means and machine-readable media may use pre-existing cellular telephone infrastructure to supplement terrestrial transmitter systems for determining the location of a receiver.", "Certain embodiments include a receiver capable of receiving LTE (Long-Term Evolution) signals and capable of executing instructions embodied in firmware, software or the like, in order to determine position location information from a received LTE-like position waveform.", "In one embodiment, positioning signals are transmitted continuously for what is referred to as a “positioning period” of up to 100 ms, allowing the receiver to integrate the received positioning signals over that positioning period.", "The positioning signals can be integrated coherently for up to 60 ms, assuming acceptable stability of a clock in the receiver, and further assuming that less than a predetermined amount of Doppler shift has been introduced in the received signal.", "For integration over a period greater than approximately 60 ms, the integration can be done non-coherently.", "Instructions may be executed by a physical layer controller that controls a radio frequency section (RF) of the receiver.", "Under the control of the firmware, the physical layer controller (i.e., PHY controller) instructs the RF section of the receiver to tune to a center frequency and indicates the number of PRB (physical resource blocks) to be used to generate the waveform.", "The center frequency is outside the LTE band.", "In addition, the number of PRBs (each having a bandwidth of 180 kHz (i.e., 12 sub-carriers multiplied by 15 kHz each) determines the bandwidth of the waveform.", "In one embodiment, the frequency to which the RF section tunes is in the M-LMS (Multilateration and Location Monitoring Service) frequency band.", "The PHY controller also instructs the RF section to receive the signal in accordance with an LTE-like format that has 40 PRBs for a bandwidth of approximately 7.2 MHz.", "The resulting signal is then pulse shaped to constrain the signal to the desired frequency mask.", "In one embodiment, the result of the pulse shaping is a signal having a bandwidth of 8 MHz.", "Alternatively, the LTE-like format has 37 PRBs for a bandwidth of 6.66 MHz which is pulse shaped to fit within a 7.5 MHz mask.", "In one embodiment, an LTE-like format can have other numbers of PRBs, where a PRB is defined according to the LTE standard.", "Each such PRB includes 12 subcarriers, and each sub-carrier has a bandwidth of approximately 15 kHz and extends for a period of 1 ms (i.e., the duration of an LTE subframe).", "A receiver may receive a waveform that includes a number of continuous subframes.", "The PHY controller may instruct the RF section to receive the number of subframes that are included in the waveform.", "In one embodiment, the waveform includes up to 100 or more subframes.", "In another embodiment, the waveform includes 60 subframes and the receiver performs coherent integration on the received signals.", "In yet another embodiment, the waveform includes 200 subframes.", "In yet another embodiment, the waveform includes n subframes, where n is greater than a standard number of subframes.", "The receiver may also decover the signal, including the PRS (position reference signal) samples, integrating them across the predetermined number of subframes to maximize the strength of the decovered positioning signal.", "By using firmware to control the PHY controller, the RF section can be controlled in a way that uses LTE standard PRBs to allow the RF section to generate a new LTE format that is particularly well-suited for generating positioning signals, such as M-LMS signals.", "Thus, the receiver may operate in accordance with the general operation of an LTE receiver, with the only change being to the firmware to instruct the RF section to generate a new waveform having a non-LTE standard number of PRBs at a non-LTE center frequency for a duration that is greater than the LTE waveform.", "A transmitter may be capable of transmitting LTE signals and capable of executing instructions to form LTE-like positioning signals having a duration of greater than 6 ms transmitted at a carrier frequency within a terrestrial positioning system spectrum, such as the spectrum used by M-LMS.", "In one embodiment, the instructions control the operation of a digital signal processor (DSP) within the physical layer of the transmitter.", "In another embodiment, the signals that are transmitted during the positioning period use a different type of modulation that is optimized for the positioning application—e.g., based on direct sequence spread spectrum (DSSS), such as employed in systems currently deployed in the M-LMS band., where LTE-based signals are transmitted at the remaining times.", "Details of embodiments are set forth in the drawings and the description below.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates a positioning system.", "FIG.", "2 depicts a simplified block diagram of an LTE transmitter.", "FIG.", "3 illustrates of one embodiment of the structure of a waveform.", "FIG.", "4 shows additional details regarding the structure of an LTE waveform.", "FIG.", "5 depicts a simplified functional block diagram of the PHY layer of a transmitter.", "FIG.", "6 illustrates an LTE waveform where there are 40 PRBs in each slot.", "FIG.", "7 depicts a simplified block diagram of a receiver that is capable of receiving positioning signals in a positioning frequency band.", "FIG.", "8 depicts a simplified functional block diagram of the PHY layer of the receiver.", "Like reference numbers and designations in the drawings indicate like elements.", "DETAILED DESCRIPTION FIG.", "1 illustrates a positioning system 100.The positioning system 100 includes any number of receivers, including a receiver 120 that receive signals from transmitters 110, satellites 150, and/or other system nodes 160 via corresponding transmitted communication signals 113, 153 and 163.The receiver 120 may also receive information from a backend system 130 through the transmitters 110 and from other receivers.", "For the sake of simplicity, the connections between the backend system 130 and each of the transmitters 110 is not shown.", "The transmitters 110 may be configured to transmit signals 113 that are received by the receiver 120.The transmitters 110 communicate with the backend 130 via the transmitted communication signals 133.In some embodiments, the transmitters 110 transmit the signals 113 using one or more common multiplexing schemes, such as time multiplexing using different time slots, code division multiplexing using different pseudorandom sequences, or frequency division multiplexing using different frequencies.", "Each of the signals 113 from each of the transmitters 110 may carry different information that, once extracted by the receiver 120 or the backend 130, may identify the following: (1) the transmitter that transmitted the signal; (2) the latitude, longitude and altitude (LLA) of that transmitter; (3) pressure, temperature and other atmospheric conditions at or near that transmitter; (4) ranging information that is used to measure a distance to that transmitter; and (5) other information.", "In one embodiment, at least one of the transmitters 110 is an LTE transmitter capable of sending signals in accordance with the LTE (Long Term Evolution) standard.", "The receiver 120 may include a location computation engine (not shown) to determine positioning information based on the signals 113, 153, and/or 163 received from the transmitters 110, the satellites 150, and/or the nodes 160.The receiver 120 may include a signal processing component (not shown) that: (1) demodulates the received signals 113, 153, and/or 163; (2) estimates positioning information like travel time of the received signals 113, 153, and/or 163; and (3) uses the positioning information to estimate the position of the receiver 120.The backend 130 communicates with various other systems, such as the transmitters 110, the receivers 120, and the other networks 160.The backend system 130 may include one or more processor(s), data source(s), and other components (not shown).", "One of ordinary skill in the art will appreciate that methods described herein may be carried out using processors at any or all of the transmitters 110, the receivers 120, the backend 130, and other components of the system 100.FIG.", "2 is a simplified block diagram of an LTE transmitter 200.An upper protocol layer module 202 determines the content that is to be transmitted based on information received from another source, such as from a backend system 130 (see FIG.", "1) or from a network, such as the internet or a telecommunications network.", "In one embodiment, the content to be transmitted is positioning information generated locally (i.e., either in a physical layer controller (PHY controller) 204 or upper protocol layers 202 of the receiver 200.Alternatively, the positioning information can be generated at a remote location and provided to the transmitter 200.In one embodiment in which the information to be transmitted is generated or received by the upper protocol layer 202, the information is provided by the upper protocol layer 202 to the PHY controller 204.The PHY controller 204 determines how much bandwidth is needed to transmit the information.", "A set of LTE parameters are provided by the PHY controller 204 to the physical layer (PHY layer) 206.In response to the LTE parameters provided to the PHY layer 206 by the PHY controller 204, the PHY layer will modulate the information onto an LTE waveform and couple the LTE waveform to a transmission antenna 208.The current LTE standard defines positioning reference signals (PRS) that are transmitted in band (i.e., at the same frequency as the voice information).", "Accordingly, the LTE standard places a limit on the duration of the PRS signal.", "In one embodiment, the PRS signals are transmitted in a positioning frequency band that is distinct from the band used to communicate other information (e.g., voice and other non-position location related data).", "FIG.", "3 illustrates the structure of an LTE waveform 300.An LTE waveform is organized as frames 301.Each of the frames 301 is ten milliseconds (ms) long, and comprises ten subframes 303.Each of the subframes 303 is one ms long, and comprises two slots 305 of 0.5 ms each.", "While a frame is ten ms long, the LTE standard limits PRS signals to a maximum of 6 subframes (i.e., 6 ms).", "Positioning signals that conform to this structure are “covered” or “spread” with a pseudo-random number (PRN) code sequence based on a “gold code” sequence.", "FIG.", "4 shows additional details regarding the structure of an LTE waveform 300.Each of the slots 305 can be used to transmit a number of physical resource blocks (PRBs) 401.Each PRB 401 has a duration of 7 symbols in time and is 12 subcarriers wide in frequency (i.e., 7×12 resource elements).", "Each subcarrier is 15 kHz wide.", "A resource element 403 represents the allocation of one symbol in time to one subcarrier in frequency.", "Accordingly, each PRB 401 comprises 84 resource elements 403.A typical LTE waveform used for cellular telephone communications has 50 PRBs centered at frequencies allocated by the Federal Communications Commission (FCC).", "When the PHY controller 204 instructs the PHY layer 206 to transmit information, the parameters that the PHY controller 204 provides the PHY layer 206 include: (1) the center frequency at which the LTE waveform is to be transmitted (i.e., the positioning frequency band carrier frequency); (2) the number of resource blocks that will be used in the waveform and (3) the number of subframes to be continuously transmitted.", "FIG.", "5 is a simplified functional block diagram of the PHY layer 206 in one embodiment.", "The number of PRBs and subframes to be used are provided to the PHY layer 206 by the PHY controller 204 (see FIG.", "2).", "For each of the slots 305, a Resource Element Grid Generator (REGG) 502 generates a resource element grid 405 based on the information provided by the PHY controller 204.In one embodiment, each of the slots 305 includes 40 PRBs 401.In one embodiment, the REGG 502 is a digital signal processor (DSP) that generates a signal having a bandwidth determined by the number of the PRBs 401 to be included in the grid 405.Alternatively, the REGG 502 is an analog signal processor or module comprising discrete components capable of generating the grid 405.The generated grid 405 is coupled to an LTE modulator 504.The LTE modulator 504 modulates position location content to be transmitted onto the signals of the generated grid 405.In one embodiment, the content is modulated using OFDM (Orthogonal Frequency Division Multiplexing) modulation.", "An output of the LTE modulator 504 is coupled to a pulse shaping filter module 506 that pulse shapes the signal to be transmitted to fit the waveform into a desired mask.", "The mask is determined based on the position frequency band requirements provided by the PHY controller 204.The position frequency band requirements include the available bandwidth and the spectral mask to be used.", "In one embodiment, these requirements are dictated by an industry standard.", "In one embodiment in which the bandwidth of the positioning signal is 8 MHz, 40 PRBs 401 are used to generate the grid 405.In an alternative embodiment, the positioning signal bandwidth is 7.5 MHz, in which case 37 PRBs are used to generate the grid 405.The output from the filter 506 is coupled to an RF signal generator 508.The RF signal generator 508 up-converts the signal to the position location carrier frequency.", "In one embodiment, the M-LMS band is used to transmit positioning signals using a waveform that is similar to the LTE waveform, but having a non-LTE carrier frequency, a number of PRBs that differ from the LTE waveform, and being transmitted with up to 200 or more subframes.", "It should be noted that as a consequence of the pulse shaping of the filter 506, the output to the RF signal generator 508 will have an 8 MHz bandwidth, even though the generated grid is 40×180 kHz=7.2 MHz.", "FIG.", "6 is an illustration of an LTE waveform generated in one embodiment in which there are 40 PRBs in each slot.", "In one such embodiment, 100 continuous subframes (having 200 slots) are transmitted together.", "In another embodiment, the number of subframes that are transmitted together can vary depending upon the conditions under which signals are being transmitted.", "Under conditions that are more challenging for the receivers, a greater number of subframes can be transmitted.", "For example, when the transmitter is operating in an urban environment, a relatively large number of subframes can be transmitted together.", "In one such embodiment, 200 or more subframes can be transmitted in a very challenging environment.", "In a less challenging environment, 60 continuous subframes or less are transmitted together.", "By continuously transmitting more subframes, the receiver can integrate over a longer period, increasing the sensitivity of the receiver.", "FIG.", "7 is a simplified block diagram of a receiver 700 in one embodiment.", "Signals transmitted from an LTE transmitter 200 are received in an antenna 702.The output from the antenna 702 is coupled to a PHY layer 704.The PHY layer 704 receives control signals from a PHY controller 706.The control signals indicate the structure of the waveform to be received, including the frequency of the carrier, the number of subframes 303 over which the received signal will be integrated, and the number of PRBs 401 to be received.", "As noted above in relation to one embodiment, the signals are received in the M-LMS band.", "Alternatively, the signals can be received at other frequencies appropriate for transmission and reception of positioning signals.", "For signals that are received with 200 or more subframes, the receiver can integrate the received signal over the entire period of 200 or more milliseconds.", "In one such embodiment in which the received signal has a bandwidth of approximately 8 MHz, the PHY controller 706 instructs the PHY layer 704 that there are 40 PRBs in each slot.", "Alternatively, the received signal may have a bandwidth of 7.5 MHz, in which case, the PHY controller 706 will instruct the PHY layer 704 that there are 37 PRBs in the received signal.", "It will be understood by those skilled in the art that the particular number of PRBs to be received may depend upon the number of PRBs in the transmitted signals.", "The number of PRBs, in turn, depends upon the bandwidth of the signal to be transmitted and the filter used within the transmitter to pulse shape the signal prior to up-converting the signal to the carrier frequency.", "FIG.", "8 is an exemplary simplified block diagram of a PHY layer 704.The received over-the-air (OTA) signals are coupled from the antenna 702 (see FIG.", "7) to a receiver down converter 801 within the PHY layer 704.The output of the down converter 801 is coupled to a searcher 803.The searcher 803 also receives signals from the PHY controller 706.The signals from the PHY controller 706 indicate the number of subframes that have been continuously transmitted and the number of PRBs in each slot of each subframe.", "The searcher 803 uses the number of PRBs to set the parameter for a PRS.", "In one embodiment, the PRS includes a gold code that is OFDM encoded into the PRBs of the received signal.", "Finding the gold code provides a means to determine the relative distance (i.e., range) from the transmitter to the receiver.", "In addition, the searcher 803 uses the number of subframes to determine how long to integrate the signal received from the down converter 801.By receiving a signal that has a relatively large number of continuously transmitted PRBs, the integration period of the searcher can be relatively long.", "Increasing the length of the integration period improves the sensitivity of the receiver.", "The output of the searcher 803 is a ranging output 805 that can be used to determine the relative distance between the transmitter and the receiver.", "Examples of Other Features in Some Embodiments Functionality and operation disclosed herein may be embodied as one or more methods implemented, in whole or in part, by machine(s)—e.g., processor(s), computers, or other suitable means known in the art—at one or more locations, which enhances the functionality of those machines, as well as computing devices that incorporate those machines.", "Non-transitory machine-readable media embodying program instructions adapted to be executed to implement the method(s) are also contemplated.", "Execution of the program instructions by one or more processors cause the processors to carry out the method(s).", "Systems (e.g., apparatuses or components thereof) operable to implement the method(s) are also contemplated.", "It is noted that method steps described herein may be order independent, and can therefore be performed in an order different from that described.", "It is also noted that different method steps described herein can be combined to form any number of methods, as would be understood by one of skill in the art.", "It is further noted that any two or more steps described herein may be performed at the same time.", "Any method step or feature disclosed herein may be expressly restricted from a claim for various reasons like achieving reduced manufacturing costs, lower power consumption, and increased processing efficiency.", "By way of example, not by way of limitation, method(s), system(s) or other means may perform the following or be operable perform the following: generating a grid of resource elements, the resource elements within the grid being grouped into physical resource blocks (PRBs); organizing the PRBs in slots, each slot having a number of the PRBs; and transmitting a plurality of the slots in a continuous transmission at a frequency within a frequency band allocated for determining position.", "In different embodiments, the number of PRBs is 40 or 37.In at least one embodiment, the slot is 0.5 milliseconds in duration.", "In at least one embodiment, each PRB comprises 7×12 resource elements.", "In different embodiments, slots are transmitted in at least 60 consecutive subframes, at least 100 consecutive subframes, or at least 200 consecutive subframes.", "In at least one embodiment, each resource element represents an allocation of one symbol in time to one OFDM (Orthogonal Frequency Division Multiplexing) sub-carrier in frequency.", "In at least one embodiment, each resource element represents an allocation of one symbol in time to one LTE OFDM (Orthogonal Frequency Division Multiplexing) sub-carrier in frequency.", "In at least one embodiment, the frequency band allocated for transmitting positioning signals is an M-LMS (Multilateration and Location Monitoring Service) band.", "Method(s), system(s) or other means may further or alternatively perform the following or be operable to perform the following: transmitting a Long Term Evolution (LTE) signal over another frequency allocated by the Federal Communications Commission (FCC) for use by cellular telephones.", "By way of example, not by way of limitation, method(s), system(s) or other means may perform the following or be operable perform the following: generating a grid of resource elements, the resource elements within the grid being grouped into physical resource blocks (PRBs); receiving an Orthogonal Frequency Division Multiplexing (OFDM) modulated positioning signal on a frequency for transmitting positioning signals; and searching for positioning information within the received positioning signal using the parameters of the generated grid of resource elements as search parameters, where the resource elements used for positioning information are contiguous.", "In different embodiments, the grid of resource elements includes 40 or 37 PRBs that are grouped together in a slot.", "In at least one embodiment, the slot is 0.5 milliseconds in duration.", "In at least one embodiment, each PRB comprises 7×12 resource elements.", "In at least one embodiment, each resource element represents the allocation of one symbol in time to one OFDM sub-carrier in frequency.", "In at least one embodiment, each resource element represents an allocation of one symbol in time to one LTE OFDM (Orthogonal Frequency Division Multiplexing) sub-carrier in frequency.", "In at least one embodiment, each resource element represents the allocation of one symbol in time to one OFDM sub-carrier in frequency.", "In different embodiments, searching for position information includes integrating the received signal over at least 60 consecutive subframes, at least 100 consecutive subframes, or at least 200 consecutive subframes.", "In at least one embodiment, the frequency band is an M-LMS (Multilateration and Location Monitoring Service) band.", "By way of example, one or more systems may comprise hardware modules that perform the methods or particular steps of the methods disclosed herein.", "In accordance with certain embodiments, a transmitter for transmitting positioning signals includes: a resource element grid generator (REGG) having first and second inputs and an output, the first input coupled to receive a signal indicating a number of physical resource blocks (PRBs) to be included in a generated grid of resource elements, and the second input coupled to receive a signal indicating a number of subframes to be consecutively transmitted by the transmitter; a modulator having a first input and an output, wherein the first input is coupled to the output of the REGG to receive a signal having a number of PRBs together in a slot and the signal having a number of slots to be consecutively transmitted from the transmitter; and a radio frequency (RF) signal generator having a first input coupled to the output of the modulator to receive a modulated waveform from the modulator, the modulated waveform having a number of consecutive slots to be contiguously transmitted at a frequency within a frequency band for transmitting a positioning signal.", "The transmitter may further comprise: a physical layer (PHY) controller, the PHY controller having a first output coupled to the first input of the REGG to provide the signal indicating the number of physical resource blocks (PRBs) to be included in the generated grid of resource elements, the PHY controller having a second output coupled to the second input of the REGG to provide the signal indicating the number of subframes to be consecutively transmitted by the transmitter.", "In at least one embodiment, the modulator has a second input coupled to the PHY controller to receive position location content to be modulated on the signal received from resource element grid generator.", "In at least one embodiment, the RF signal generator has second input to receive information regarding a carrier frequency to be used for transmitting the positioning signals.", "In different embodiments, the received signal indicating the number of PRBs to be included in the generated grid of resource elements indicates that 40 or 37 PRBs are to be included in the generated grid of resource elements.", "In at least one embodiment, each PRB comprises 7×12 resource elements.", "In at least one embodiment, each resource element represents the allocation of one symbol in time to one OFDM sub-carrier in frequency.", "In at least one embodiment, each resource element represents the allocation of one symbol in time to one OFDM sub-carrier in frequency.", "In different embodiments, the received signal indicating the number of subframes to be consecutively transmitted by the transmitter indicates that the number of subframes to be consecutively transmitted is 60, 100 or 200.In at least one embodiment, the frequency band allocated by the FCC for transmitting positioning signals is an M-LMS (Multilateration and Location Monitoring Service) band.", "In accordance with certain embodiments, a receiver of positioning signals includes: a down converter having a first input to receive an Orthogonal Frequency Division Multiplexing (OFDM) modulated positioning signal, the down converter having a second input to receive information regarding a carrier frequency of the received positioning signal; and a searcher having a first input coupled to receive a signal indicating a number of physical resource blocks (PRBs) to be included in a search for position information within the received positioning signal, and having a second input coupled to receive a signal indicating a number of subframes over which the searcher is to integrate the received positioning signal in performing the search for positioning information.", "In different embodiments, the received positioning signal comprises a plurality of consecutively transmitted slots, each slot of the received positioning signal having 40 or 37 PRBs.", "In different embodiments, the signal indicating the number of PRBs indicates that there are 40 or 37 PRBs in each slot of the received positioning signal.", "In different embodiments, the received positioning signal comprises 60, 100 or 200 subframes.", "In different embodiments, the signal indicating the number of subframes indicates that the search is to integrate across 60, 100 or 200 subframes of the received signal.", "In at least one embodiment, each PRB comprises 7×12 resource elements.", "In at least one embodiment, each resource element represents the allocation of one symbol in time to one OFDM sub-carrier in frequency.", "In at least one embodiment, each resource element represents the allocation of one symbol in time to one OFDM sub-carrier in frequency.", "In at least one embodiment, each module includes one or more inputs to receive information used to perform what it is operable to do, and further includes one or more outputs to send information to other modules.", "A “receiver” may be in the form of a computing device (e.g., a mobile phone, a tablet, a PDA, a laptop, a digital camera, a tracking tag).", "A receiver may also take the form of any component of the computer, including a processor.", "Processing by the receiver can also occur at a server.", "The illustrative methods described herein may be implemented, performed, or otherwise controlled by suitable hardware known or later-developed by one of skill in the art, or by firmware or software executed by processor(s), or any combination of hardware, software and firmware.", "Software may be downloadable and non-downloadable at a particular system.", "Such software, once loaded on a machine, changes the operation of that machine.", "Systems on which methods described herein are performed may include one or more means that implement those methods.", "For example, such means may include processor(s) or other hardware that, when executing instructions (e.g., embodied in software or firmware), perform any method step disclosed herein.", "A processor may include, or be included within, a computer or computing device, a controller, an integrated circuit, a “chip”, a system on a chip, a server, other programmable logic devices, other circuitry, or any combination thereof.", "“Memory” may be accessible by a machine (e.g., a processor), such that the machine can read/write information from/to the memory.", "Memory may be integral with or separate from the machine.", "Memory may include a non-transitory machine-readable medium having machine-readable program code (e.g., instructions) embodied therein that is adapted to be executed to implement any or all of the methods and method steps disclosed herein.", "Memory may include any available storage media, including removable, non-removable, volatile, and non-volatile media—e.g., integrated circuit media, magnetic storage media, optical storage media, or any other computer data storage media.", "As used herein, machine-readable media includes all forms of machine-readable media except to the extent that such media is deemed to be non-statutory (e.g., transitory propagating signals).", "All of the information disclosed herein may be represented by data, and that data may be transmitted over any communication pathway using any protocol, stored on data source(s), and processed by a processor.", "Transmission of data may be carried out using a variety of wires, cables, radio signals and infrared light beams, and an even greater variety of connectors, plugs and protocols even if not shown or explicitly described.", "Systems may exchange information with each other using any communication technology.", "Data, instructions, commands, information, signals, bits, symbols, and chips and the like may be represented by voltages, currents, electromagnetic waves, magnetic fields or particles, or optical fields or particles.", "Features in system figures that are illustrated as rectangles may refer to hardware, firmware or software.", "It is noted that lines linking two such features may be illustrative of data transfer between those features.", "Such transfer may occur directly between those features or through intermediate features.", "Where no line connects two features, transfer of data between those features is contemplated unless otherwise stated.", "When two things (e.g., modules, circuit elements, etc.)", "are “coupled to” each other, those two things may be directly connected together, or may be separated by one or more intervening things.", "Thus, no direct connection is required between the two things.", "Where an output and an input are coupled to each other, data and/or signaling sent from the output is received by the input even if the data passes through one or more intermediate things.", "The words comprise, comprising, include, including and the like are to be construed in an inclusive sense (i.e., not limited to) as opposed to an exclusive sense (i.e., consisting only of).", "Words using the singular or plural number also include the plural or singular number, respectively.", "The word or and the word and, as used in the Detailed Description, cover any of the items and all of the items in a list.", "The words some, any and at least one refer to one or more.", "The term may is used herein to indicate an example, not a requirement—e.g., a thing that may perform an operation or may have a characteristic need not perform that operation or have that characteristic in each embodiment, but that thing performs that operation or has that characteristic in at least one embodiment.", "It is noted that the term “GPS” may refer to any Global Navigation Satellite Systems (GNSS), such as GLONASS, Galileo, and Compass/Beidou, and vice versa." ] ]
Patent_15876045
[ [ "SEMICONDUCTOR PACKAGE WITH CANTILEVER PADS", "One or more embodiments are directed to semiconductor packages with one or more cantilever pads and methods of making same.", "In one embodiment a recess is located in a substrate of the package facing the cantilever pad.", "The cantilever pad includes a conductive pad on which a conductive ball is formed.", "The cantilever pad is configured to absorb stresses acting on the package." ], [ "1.A method, comprising: forming a recess in a first surface of a first layer of insulative material; covering the recess with a second layer of insulative material, a layer of conductive material located on the second layer and extending over a portion of the recess; and forming a through hole in the second layer of insulative material to form a cantilever pad over the recess.", "2.The method of claim 1, further comprising forming a conductive ball on the cantilever pad.", "3.The method of claim 1, further comprising forming a conductive through via through the first and second layers, the conductive through via being electrically coupled to the cantilever pad.", "4.The method of claim 3 wherein the conductive through via is coupled to a pad on a second surface of the first layer, the second surface being opposite the first surface, the pad being electrically coupled to the cantilever pad.", "5.The method of claim 4, further comprising coupling a semiconductor die to the second surface of the first layer and electrically coupling the semiconductor die to the pad.", "6.The method of claim 1 wherein forming the through hole comprises forming a U-shaped, C-shaped, or V-shaped through hole around the layer of conductive material extending over the portion of the recess.", "7.A method, comprising: forming a recess in a first surface of a substrate that includes insulative material; partially covering the recess with a cantilevered pad, the cantilevered pad being configured to flex into the recess; and attaching a solder ball to the cantilevered pad.", "8.The method of claim 7, further comprising coupling a semiconductor die to a second surface of the substrate, the second surface being opposite the first surface, and electrically coupling the semiconductor die to the cantilevered pad.", "9.The method of claim 8 wherein electrically coupling the semiconductor die to the cantilevered pad includes coupling a first end of a wire to a bond pad of the semiconductor die and coupling a second end of the wire to a pad on a second surface of the substrate, wherein the pad on the second surface of the substrate is coupled to the cantilevered pad by a conductive through via in the substrate.", "10.The method of claim 7 wherein partially covering the recess comprises: coupling a layer of insulative material to the first surface of the substrate; forming a conductive layer on the layer of the insulative material; and forming a through hole that extends through an entire thickness of the layer of insulative material.", "11.The method of claim 10 wherein coupling the layer of insulative material to the first surface of the substrate comprises laminating the layer of insulative material to the first surface of the substrate.", "12.The method of claim 10 wherein forming the through hole comprises forming a through hole that is U, C, or V shaped.", "13.The method of claim 7 wherein forming the recess in the first surface of the substrate comprises forming a plurality of recesses in the first surface of the substrate, and wherein partially covering comprises partially covering the plurality of recesses with cantilevered pads, respectively.", "14.A method, comprising: forming a recess in a first surface of a first layer of insulative material; coupling the first layer and a second layer of insulating material together, the second layer covering the recess; depositing a conductive material on the second layer, the conductive material located over a portion of the recess; and forming a through hole in the second layer of insulative material, the through hole of the second layer being in fluid communication with the recess of the second layer, wherein forming the through hole includes forming a cantilever pad, a portion of the conductive material deposited on the second layer being located on the cantilever pad.", "15.The method of claim 14 wherein coupling the first and second layers together comprises laminating the first and second layers together.", "16.The method of claim 14 wherein forming the through hole in the second layer occurs after coupling the first and second layers together.", "17.The method of claim 14 wherein forming the through hole comprises forming a U-shaped, C-shaped, or V-shaped through hole.", "18.The method of claim 14, further comprising: securing a semiconductor die to the first surface of the first layer; and electrically coupling the semiconductor die to the conductive material on the second layer and on the cantilever pad.", "19.The method of claim 14 wherein forming the recess comprises forming a plurality of recesses and forming the through hole comprises forming a plurality of through holes." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> BRIEF SUMMARY <EOH>One or more embodiments are directed to semiconductor packages with one or more cantilever pads and methods of making same.", "In one embodiment a recess is located in a substrate of the package facing the cantilever pad.", "The cantilever pad includes a conductive pad on which a conductive ball is formed.", "The cantilever pad is configured to absorb stresses acting on the package.", "For instance, the cantilever pad may be configured to flex into the recess and/or flex outwardly therefrom.", "In that regard, the cantilever pad may respond readily in response to stress that is acting on various materials of the semiconductor package.", "For instance, during operation, the cantilever pad may be configured to flex inward, toward the recess, and/or outward, away from the recess, in response to expansion of one or more materials caused by various materials having differing CTEs and expanding at differing rates.", "Thus, the likelihood of cracks being formed in electrical structures of the package or a PCB coupled to the package is reduced.", "In one embodiment, the cantilever pad may prevent or reduce the likelihood of cracks occurring in conductive balls that electrically couple the package to the PCB." ], [ "BACKGROUND Technical Field Embodiments of the present disclosure are directed to semiconductor packages and methods of making same.", "Description of the Related Art Reliability of semiconductor packages is of significant importance.", "Although various issues cause reliability problems in semiconductor packages, one known reason for reliability issues is that packages and the boards, onto which the package are mounted, are formed of various types of materials, each having different coefficients of thermal expansion (CTE).", "During use, heat is generated, and due to differing CTEs, stress may be introduced into the package and/or the board, which can cause cracks, for instance, in solder joints that couple the semiconductor package to a printed circuit board (PCB), thereby affecting board level reliability of the package by disrupting the electrical coupling between the package and the PCB.", "BRIEF SUMMARY One or more embodiments are directed to semiconductor packages with one or more cantilever pads and methods of making same.", "In one embodiment a recess is located in a substrate of the package facing the cantilever pad.", "The cantilever pad includes a conductive pad on which a conductive ball is formed.", "The cantilever pad is configured to absorb stresses acting on the package.", "For instance, the cantilever pad may be configured to flex into the recess and/or flex outwardly therefrom.", "In that regard, the cantilever pad may respond readily in response to stress that is acting on various materials of the semiconductor package.", "For instance, during operation, the cantilever pad may be configured to flex inward, toward the recess, and/or outward, away from the recess, in response to expansion of one or more materials caused by various materials having differing CTEs and expanding at differing rates.", "Thus, the likelihood of cracks being formed in electrical structures of the package or a PCB coupled to the package is reduced.", "In one embodiment, the cantilever pad may prevent or reduce the likelihood of cracks occurring in conductive balls that electrically couple the package to the PCB.", "BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS In the drawings, identical reference numbers identify similar elements.", "The sizes and relative positions of elements in the drawings are not necessarily drawn to scale.", "FIG.", "1A is a cross-sectional view of a semiconductor package in accordance with one embodiment of the disclosure.", "FIG.", "1B is a close-up cross-sectional view of the package of FIG.", "1.FIG.", "1C is a close-up bottom view of the close-up view of FIG.", "1B.", "FIG.", "2 is a close-up cross sectional view of the package of FIG.", "1 coupled to another device.", "FIG.", "3 illustrates a bottom surface of a package that includes some cantilever pads in accordance with one embodiment.", "FIGS.", "4A-4H illustrate cross-sectional views illustrating the packages of FIG.", "1 being assembled in the close-up view of FIG.", "1B at various stages of manufacture in accordance with one embodiment.", "DETAILED DESCRIPTION It will be appreciated that, although specific embodiments of the present disclosure are described herein for purposes of illustration, various modifications may be made without departing from the spirit and scope of the present disclosure.", "In the following description, certain specific details are set forth in order to provide a thorough understanding of various aspects of the disclosed subject matter.", "However, the disclosed subject matter may be practiced without these specific details.", "In some instances, well-known structures and methods of semiconductor processing comprising embodiments of the subject matter disclosed herein have not been described in detail to avoid obscuring the descriptions of other aspects of the present disclosure.", "FIG.", "1A shows a cross-sectional view of a package 10 in accordance with one embodiment of the disclosure.", "FIG.", "1B shows a close-up view of a portion of FIG.", "1A.", "The package 10 includes a semiconductor die 12 on an upper surface 13 of a substrate 14.The semiconductor die 12 includes electrical structures of an electrical device, such as an integrated circuit.", "The substrate 14 has a lower surface 15 opposite the upper surface 13 and includes one or more conductive and insulative layers.", "In the illustrated embodiment, the substrate 14 includes first and second layers 17, 19 of insulative material; however, the substrate 14 may include any number of insulative layers.", "The insulative layers may include any insulative material including ceramic, glass, polymer, or any other suitable insulative material.", "The one or more conductive layers may be any conductive material, such as a metal material.", "In one embodiment, the conductive layers are copper.", "The semiconductor die 12 is coupled to the upper surface 13 of the substrate 14 by an adhesive material 18.The adhesive material 18 may be any adhesive material 18 that bonds the semiconductor die 12 to the upper surface 13 of the substrate 14, such as paste, glue, epoxy, double-sided tape, or any other suitable material.", "The upper surface 13 of the substrate 14 includes a plurality of conductive fingers 20 located near one or more edges of the semiconductor die 12.Although only two conductive fingers 20 are shown, it is to be appreciated that any number of conductive fingers 20 may be provided, including just one.", "In some embodiments, a plurality of conductive fingers 20 is located on each side of the semiconductor die 12.In general, the conductive fingers 20 are electrically isolated from each other, however, two or more may be coupled together by one or more conductive traces.", "The semiconductor die 12 is electrically coupled to the conductive fingers 20.In particular, the electrical device of the semiconductor die 12 is coupled to the conductive fingers 20 by conductive wires 22.More particularly, a first end 24 of the conductive wire 22 is coupled to a bond pad of the semiconductor die 12, which may be coupled to various electrical components of the electrical device, and a second end 26 of the conductive wire is coupled to the conductive finger.", "In another embodiment, the electrical device of the semiconductor die 12 is coupled to the conductive fingers 20 by flip chip arrangement as is well known in the art.", "In that regard, the conductive fingers 20 would be located under the semiconductor die 12 and coupled to the bond pads of the semiconductor die 12 by conductive balls.", "The lower surface 15 of the substrate 14 includes a plurality of cantilever pads 26.As best shown in FIG.", "1B, the cantilever pads 26 include a conductive pad 28 that is supported by a substrate support portion 30.On the conductive pad 28 of the cantilever pad 26 is a conductive ball 31, such as a solder ball, that is configured to couple the package 10 to another substrate or board, such as a PCB 50 (FIG.", "2).", "The cantilever pads 26 are cantilevered by recesses 32 located above the cantilever pads 26 and by through openings 33 in the substrate 14 along three sides of the cantilever pads 26.In particular, the recesses 32 are located in the first layer 17 and the through openings 33 are located the second layer 19 in communication with the recesses 32.As best shown in FIG.", "1C, through openings 33 extend from one end and along side surfaces of the cantilever pads 26 forming a C-shape in planar view.", "The through openings 33, in planar view, may be any shape that forms a cantilever pad with the recess 32.For instance, the through openings 33 may also be V-shaped or U-shaped.", "The thickness of the cantilever pad 26 is any thickness that provides suitable structural support for the cantilever pad 26 when the package 10 is attached to another substrate or board, while also allowing some flexing of the cantilever pad 26.The cantilever pad 26 may allow flexing in one direction, such as into or away from the recess 32, or in two directions, such as both into and away from the recess 32.The recess 32 may have a depth that is sufficient to provide adequate clearance in view of the flexing of the cantilever pad 26 into the recess 32 such that an upper surface of the cantilever pad 26 does not abut against the inner surface of the substrate 14 that delimits the recess 32.The conductive fingers 20 are electrically coupled to conductive pads 28 of the cantilever pads 26 by one or more conductive traces 36 and through vias 38 that extend through the substrate 14.That is, the conductive fingers 20 are coupled to the trace 36 located above the first layer 17.The trace 36 on the first layer 17 is coupled to the trace 36 on the second layer 19 by through vias 38 that extend through the first and second layers 17, 19 of the substrate 14.In the illustrated embodiment, an inner trace 44 couples the through via 38 in the first layer 17 to the through via 38 in the second layer 19.A dielectric material 46 is located over the traces 36 and on the first and second surfaces of the substrate 14.The dielectric material 46 may be any material that can provide protection from environmental sources of damage, such as corrosion, physical damage, moisture damage, or other causes of damage to electrical features.", "In one embodiment, the dielectric material 46 is a solder mask material.", "The solder mask may be a liquid material that hardens, such as during a curing process.", "Encapsulation material 48 is located over the substrate, surrounding the die, the conductive fingers 20, and the conductive wires 22.The encapsulation material 48 may be any material configured to provide protection from environmental sources of damage, such as corrosion, physical damage, moisture damage, or other causes of damage to electrical devices.", "The encapsulation material 48 may be a molding compound that includes one or more of polymer, polyurethane, acrylic, epoxy resin, silicone, or any other suitable material.", "FIG.", "2 shows a portion of the package 10 coupled to a board, such as a printed circuit board (PCB) 50 by the conductive balls 31.As shown in FIG.", "2, the cantilever pad 26 flexes into the recess 32.The cantilever pad 26 may be able to absorb stresses created in various materials or components of the package or components coupled to the package.", "In particular, the cantilever pad 26 can move into and/or away from the recess 26 in response to forces, such as those caused by thermal expansion of one or more components, thereby preventing or reducing the likelihood of cracks being formed in electrical components, such as conductive balls 31.Due to the flexibility of cantilever pad 26, the conductive joint reliability or solder joint reliability of the package 10 is improved.", "The cantilever pad 26 may flex into the recess 32 during the mounting process in which the package 10 is mounted to the PCB 50 as well.", "For instance, due to nonplanar conductive balls 31 (e.g., standoff height differences of the conductive balls), some cantilever pads 26 may flex inward or outward from the recess.", "In some embodiments, pressure may be applied during mount, thereby placing a force on the cantilever pads 26 to move inward.", "Nonplanar conductive balls may be caused by dispensing different proportions of conductive material that form the balls or by warping of various components of the package.", "The package 10 may include any number of cantilever pads 26.In one embodiment, all of the conductive pads of a package are cantilever pads 26.In other embodiments, only some of the conductive pads of a package are cantilever pads 26, while the other conductive pads are not cantilevered.", "In one embodiment, cantilever pads 26 are positioned on the package in locations that correspond to the largest amount of expected stress to be applied to the pad and conductive bump located on the pad.", "FIG.", "3 illustrates a layout of a bottom surface of a package 10a that includes conductive balls 31 secured to cantilever pads 26 as described above and traditional pads 27 that are not cantilevered.", "That is, the cantilever pads 26 and conductive bump 31 are located at the perimeter of the package 10a, while the conductive pads 27 and conductive bump 31 at the center of the package 10a are traditional, non-cantilevered pads.", "In some embodiments, during thermal expansion, the conductive pads and bumps located at the perimeter of a package may be exposed to greater stresses than the central pads.", "In that regard, the cantilever pads 26 at an outer perimeter of the package are able to flex in response to stress induced therein, while the center pads are not exposed to substantial stresses.", "FIGS.", "4A-4H illustrate cross-sectional views illustrating the package 10 of FIG.", "1A being assembled in the close-up view of FIG.", "1B at various stages of manufacture in accordance with one embodiment.", "FIG.", "4A shows a first layer 17 of insulative core material which may be ceramic, glass, polymer, or any suitable core material.", "Although not shown, the first layer 17 may, in some embodiments, be coupled to a support structure during at least a portion of the processing.", "The first layer 17 of insulative material has a first surface 62 and a second surface 64.As shown in FIG.", "4B, portions of the first layer 17 of the insulative material are removed.", "In particular, recesses 32 are formed in the second surface 64 of the first layer 17 and through holes 66 are formed that extend from the first surface 62 to the second surface 64.The recesses 32 correspond to locations for the cantilever pads 26 and the through holes 66 correspond to locations for the conductive through vias 38 of FIGS.", "1A and 1 B.", "The recess 32 and through hole 66 are formed using standard semiconductor processing, including patterning the second surface using light sensitive material, such as photoresist and etching, such as wet and/or dry etching.", "Although only one recess and through hole are shown, it will be clear to persons of ordinary skill in the art that a plurality of recesses 32 and through holes 66 are formed in the second surface 64 of the first layer 17.As shown in FIG.", "4C, the through hole 66 is filled with a conductive material to form a conductive through via 38.Similarly, conductive material is deposited on the first and second surfaces 62, 64 of the first layer 17 above and below the conductive through vias 38 forming traces 36 and the conductive fingers 20.The deposition is performed using standard semiconductor processing techniques, which may include patterning the conductive material or blanket depositing the conductive material and then removing portions of the conductive material to form traces and conductive fingers.", "As mentioned above, the conductive material may be any conductive material, and in one embodiment is copper.", "In another embodiment the conductive material in the through via may be different from the conductive material forming the traces.", "As shown in FIG.", "3D, a second layer 19 of insulative material is secured to the second surface 64 of the first layer 17.The second layer 19 may be secured to the first layer 17 by any method, including by lamination, which may include pressure and/or heat.", "The thickness of the second layer 19 varies depending on the material properties used for the second layer 19 and may also depend on the mechanical properties of the conductive material that forms the trace 36 and conductive pad 28.In an embodiment, in which the second layer 19 is ceramic, the second layer 19 may be a thin film.", "As shown in FIG.", "4D, a through hole 68 is formed in the second layer 19 below the conductive through via 38 in the first layer 17.The through hole 68 is formed using standard processing techniques including patterning and etching as referenced above.", "The through hole 68 may be formed prior to securing the second layer 19 to the first layer 17 or after.", "As shown in FIG.", "4E, conductive material is deposited in the through hole 68 of the second layer 19 to form a conductive through via 38.The through via 38 of the second layer 19 is electrically coupled to the through via 38 of the first layer 17 by the inner trace 44.It is noted that the inner trace 44 extends laterally beyond the through vias 38.The inner trace 44 may resolve any misalignment issues that occur between the through via 38 of the first layer 17 and the through via 38 of the second layer 19 in view of the through holes 66 and 68 being etched in different processing steps.", "As shown in FIG.", "4E, a conductive material is deposited on the bottom surface of the second layer 19 to form trace 36 and conductive pad 28.The conductive material may be deposited and patterned using standard semiconductor techniques referenced above.", "As shown in FIG.", "4F, a dielectric layer 46 is deposited over portions of the first and second layers 17, 19 and various structures on the first and second layers 17 19, such as traces 36.The dielectric layer 46 is deposited by standard semiconductor processing techniques, including blanket deposition with patterning and etch or patterning light sensitive material then patterned deposition.", "As mentioned above, the dielectric layer 46 may be formed by depositing a liquid material that hardens.", "The liquid material may harden over time or may harden in a heating or curing step.", "As shown in FIG.", "4F, the conductive pad 28 on the second layer 19 remains exposed and conductive finger 20 on the first layer 17 remains exposed.", "Additionally, a portion 70 of the second layer 19 remains uncovered by the dielectric layer 46.The portion 70 is at least partially located below the recess 32.The portion 70 that remains open has a shape that corresponds to the shape of the through opening 33 in FIG.", "1C.", "As indicated above, the shape of the portion 70, however, may be any shape that when etched away causes a portion of the second layer 19 to form the cantilever pad 26 with the recess 32.Thus, the shape may be any two or three-sided shape, such as a C-shape, U-shape, V-shape, or any other suitable shape.", "As shown in FIG.", "4G, the portion 70 of the second layer 19 below the recess is removed, such as in a dry or wet etch step.", "In one embodiment, the dielectric material acts as an etch mask.", "Upon removal of the portion 70 of the second layer 19, the cantilever pad 26 is formed.", "As shown in FIG.", "4H, the semiconductor die 12 is coupled to the upper surface 13 of the substrate 14 by the adhesive material 18.That is, the adhesive material may be applied to one or both of the upper surface 13 and a back surface of the semiconductor die 12.The conductive wire 22 is coupled between the semiconductor die 12 and the conductive finger 20 as is well known in the art.", "An encapsulation material 48 is formed over the upper surface 13 of the substrate 14, encapsulating various components of the package.", "The encapsulation material may be formed using standard semiconductor processing techniques, including using a mold in which molding compound is injected therein and around the various components.", "The molding compound then hardens in a hardening step, which may include a curing or heat step.", "Conductive ball 31 may be formed on the cantilever pad 26, such as by solder dispensing techniques.", "In other embodiments, however, the conductive ball 31 is formed on another device to which the package 10 will be coupled.", "It is to be understood that the method steps can be performed in any order and thus may be in a different order than is shown and described.", "For instance, the through opening 33 may be formed in the second layer 19 before coupling the first and second layers 17, 19 together.", "The various embodiments described above can be combined to provide further embodiments.", "All of the U.S. patents, U.S. patent application publications, U.S. patent applications, foreign patents, foreign patent applications and non-patent publications referred to in this specification and/or listed in the Application Data Sheet are incorporated herein by reference, in their entirety.", "Aspects of the embodiments can be modified, if necessary to employ concepts of the various patents, applications and publications to provide yet further embodiments.", "These and other changes can be made to the embodiments in light of the above-detailed description.", "In general, in the following claims, the terms used should not be construed to limit the claims to the specific embodiments disclosed in the specification and the claims, but should be construed to include all possible embodiments along with the full scope of equivalents to which such claims are entitled.", "Accordingly, the claims are not limited by the disclosure." ] ]
Patent_15876046
[ [ "APPLICATION SPECIFIC INTEGRATED CIRCUIT INTERCONNECT", "Systems and methods for providing Chronos Channel interconnects in an ASIC are provided.", "Chronos Channels rely on a reduced set of timing assumptions and are robust against delay variations.", "Chronos Channels transmit data using delay insensitive (DI) codes and quasi-delay-insensitive (QDI) logic.", "Chronos Channels are insensitive to all wire and gate delay variations, but for those belonging to a few specific forking logic paths called isochronic forks.", "Chronos Channels use temporal compression in internal paths to reduce the overheads of QDI logic and efficiently transmit data.", "Chronos Channels are defined by a combination of a DI code, a temporal compression ratio and hardware." ], [ "1.A point-to-point connection between a first intellectual property (IP) block and a second IP block of an application specific integrated circuit (ASIC), the point-to-point connection comprising: a transmitter (TX) associated with the first IP block, the TX comprising one or more delay insensitive (DI) encoders and one or more temporal compressors, and configured to transform input data signals from the first IP block into one or more temporally compressed DI asynchronous signals and transmit the temporally compressed DI asynchronous signals via a channel; a receiver (RX) associated with the second IP block, the RX comprising one or more DI decoders and one or more temporal decompressors, and configured to receive the one or more DI asynchronous signals via the channel and restore the one or more compressed DI asynchronous signals to form a representation of the input data signals compliant to an input data format of the second IP block; and wherein the channel is a timing independent channel between the first IP block and the second IP block, wherein the one or more DI asynchronous signals from the TX are propagated via the timing independent channel in a self-timed fashion to the RX.", "2.The point-to-point connection as recited in claim 1, wherein the TX is configured to encode data symbols comprising two elements (a,b) using DI encoding that relies on three codewords A, B, and C and the RX is configured to decode the codewords (A,B,C) using DI encoding to form duplicates of the data symbols (a,b).", "3.The point-to-point connection as recited in claim 1, wherein the TX is configured to encode data symbols comprising two elements (a,b) using DI encoding that relies on four codewords A, B, C and D, and the RX is configured to decode the codewords (A,B,C and D) using DI decoding to form duplicates of the data symbols (a,b).", "4.The point-to-point connection as recited in claim 1, wherein the TX is configured to encode data symbols comprising four elements (a,b,c,d) using DI encoding that relies on four symbols A, B, C and D, and the RX is configured to decode the codewords (A,B,C and D) using DI decoding to form duplicates of the data symbols (a, b, c, d).", "5.The point-to-point connection as recited in claim 1, wherein the TX is configured to use a selected one of a plurality of DI encoding schemes to transform the input data signals into the compressed DI asynchronous signals and the RX is configured to restore the one or more compressed DI asynchronous signals to form the representation of the input data signals compliant to the input data format of the second IP block." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>Apparatuses and methods for ASIC design are provided.", "According to various aspects, there is provided a point-to-point connection between a first intellectual property (IP) block and a second IP block of an application specific integrated circuit (ASIC).", "The point-to-point connection may comprise a transmitter (TX) associated with the first IP block, the TX comprising one or more delay insensitive (DI) encoders and one or more temporal compressors, and configured to transform input data signals to the first IP block into one or more temporally compressed DI asynchronous signals and transmit the temporally compressed DI asynchronous signals via a channel.", "The point-to-point connection may further comprise a receiver (RX) associated with the second IP block, the RX comprising one or more DI decoders, and configured to receive the one or more DI asynchronous signals via the channel and restore the one or more compressed DI asynchronous signals to form a representation of the input data signals compliant to an input data format of the second IP block; and wherein the channel is a timing independent channel between the first IP block and the second IP block, wherein the one or more DI asynchronous signals from the TX are propagated via the timing independent channel in a self-timed fashion to the RX.", "According to various aspects, there is provided a point-to-multipoint connection between a first intellectual property (IP) block and a plurality of IP blocks.", "The point-to-multipoint connection may comprise a transmitter (TX) associated with the first IP block, the TX comprising one or more delay insensitive (DI) encoders and one or more temporal compressors, and configured to transform input data signals from the first IP block into temporally compressed DI asynchronous signals.", "The a point-to-multipoint connection may further comprise a timing independent channel between the TX and a Flow Control block, wherein the DI asynchronous signal from the TX is propagated via the timing independent channel in a self-timed fashion to the Flow Control block; the Flow Control block comprising a quasi-delay-insensitive (QDI) Flow Control element configured to broadcast or selectively propagate the compressed DI asynchronous signals to a plurality of individual timing independent channels; and multiple receivers (RXs) associated with receiving IP blocks, each RX comprising one or more DI decoders and one or more temporal decompressors, and configured to receive the DI asynchronous signals from the Flow control block and restore the compressed DI asynchronous signals received from the the Flow Control block to form duplicates of the input data signals.", "According to various aspects, there is provided a multipoint-to-point connection between a transmitting Intellectual Property (IP) block and a plurality of receiving IP blocks.", "The multipoint-to-point connection may comprise a plurality of transmitters (TXs) each associated with respective transmitting IP blocks, each TX comprising one or more delay insensitive (DI) encoders and one or more temporal compressors, and configured to transform input data signals received from the transmitting IP blocks into temporally compressed DI asynchronous signals.", "The multipoint-to-point connection may further comprise a plurality of timing independent channels between the TXs and individual inputs of a Flow Control block, wherein the compressed DI asynchronous signals from the TXs are propagated via timing independent channels in a self-timed fashion to the Flow Control block; the Flow Control block comprising a QDI Flow Control element configured to merge or selectively propagate the individual timing independent channels; anda receiver (RX) associated with the receiving IP block, the RX comprising one or more DI decoders and one or more temporal decompressors, and configured to restore the compressed DI asynchronous signal received from the Flow Control block to form duplicates of the input data signals.", "According to various aspects, there is provided a multipoint-to-multipoint connection between a plurality of transmitting IP blocks and a plurality of receiving IP blocks.", "The multipoint-to-multipoint connection may comprise a plurality of transmitters (TXs) each associated with a respective one of the transmitting IP blocks, each TX comprising one or more delay insensitive (DI) encoders and one or more temporal compressors, and configured to transform input data signals from the IP block into temporally compressed DI asynchronous signals.", "The multipoint-to-multipoint connection may further comprise timing independent channels between the TXs and individual inputs of a Flow Control block, wherein the DI asynchronous signals from the TXs are propagated via the timing independent channels in a self-timed fashion to the Flow Control block; the Flow Control block comprising a QDI Flow Control element configured to merge or selectively propagate the DI asynchronous signals to the individual timing independent channels; the QDI Flow Control element further configured to broadcast or selectively propagate the DI asynchronous signals to the individual timing independent channels; and multiple receivers (RXs) associated with the receiving IP blocks, each RX comprising one or more DI decoders and one or more temporal decompressors, and configured to receive the compressed DI asynchronous signals via the individual timing independent channels and restore the compressed DI asynchronous signal to form duplicates of the input data signals.", "Other features and advantages of the present inventive concept should be apparent from the following description which illustrates by way of example aspects of the present inventive concept." ], [ "RELATED APPLICATIONS INFORMATION This present application is a continuation of U.S. patent application Ser.", "No.", "15/344,416, entitled “Application specific integrated circuit interconnect,” filed on Nov. 4, 2016, which claims the benefit of priority under 35 U.S.C.", "119(e) to Provisional Patent Application Ser.", "No.", "62/372,217, entitled “Application Specific Integrated Circuit Point-to-Point Interconnect,” filed Aug. 8, 2016 and claims the benefit of priority under 35 U.S.C.", "119(e) to Provisional Patent Application Ser.", "No.", "62/250,998, entitled “Application Specific Integrated Circuit Point-to-Point Interconnect,” filed Nov. 4, 2015, all of which are incorporated herein by reference as if set forth in full.", "BACKGROUND 1.Technical Field The various embodiments described herein are related to application specific integrated circuits (ASICs), and more particularly to the design of various ASICs.", "2.Related Art Continuing advances in semiconductor device fabrication technology have yielded a steady decline in the size of process nodes.", "For example, 22 nanometer (nm) process nodes were introduced in 2012 but were quickly succeeded by 14 nm fin field-effect transistors (FinFETs) in 2014 while 5 nm process nodes are projected for 2020.The decrease in process node size allows a growing number of intellectual property (IP) cores or IP blocks to be placed on a single ASIC chip.", "That is, modern ASIC designs often spread numerous process nodes across a comparatively large silicon die, and include combinations of IP blocks and logic functions.", "At the same time, modern technology also requires increased connectivity and large data transfers between various IP blocks.", "In addition, modern ASIC chips frequently include multiple clock domains in order to leverage multi-core implementations.", "Thus, one or more clock signals may need to be distributed across the chip in a manner that minimizes clock skew.", "For instance, the edge of the clock signal received at a logic block located near a clock source should be aligned with those received at more distant logic blocks.", "Conventionally, a balanced clock signal distribution (i.e., timing closure) is achieved by inserting buffers.", "For example, pursuant to a traditional ASIC design flow, after floor planning and placing various IP blocks, a clock tree (i.e., a clock distribution network) may be synthesized and buffers may be added along the signal path from a clock source to various IP blocks according to the clock tree.", "In fact, timing closure for a clock signal that is distributed over a large and complex ASIC design typically requires the strategic placement of numerous buffers.", "Moreover, the distribution of a clock signal is also highly susceptible to both systematic and random variations.", "In particular, proper timing closure must account for the effects of on-chip variations that arise as a result of different process, voltage, and temperature (PVTs) and operation modes, which would otherwise introduce additional clock skews.", "As such, the most laborious and time consuming aspect of conventional ASIC design tends to be clock alignment.", "Clock tree synthesis and timing closure generally require significant manual intervention.", "In addition, the mechanisms (i.e., buffers) used to balance the clock across an ASIC chip generally consume a majority of the power in any conventional ASIC design.", "Therefore, what is needed are an apparatus and method that overcome these significant problems found in the aforementioned conventional approach to ASIC design.", "SUMMARY Apparatuses and methods for ASIC design are provided.", "According to various aspects, there is provided a point-to-point connection between a first intellectual property (IP) block and a second IP block of an application specific integrated circuit (ASIC).", "The point-to-point connection may comprise a transmitter (TX) associated with the first IP block, the TX comprising one or more delay insensitive (DI) encoders and one or more temporal compressors, and configured to transform input data signals to the first IP block into one or more temporally compressed DI asynchronous signals and transmit the temporally compressed DI asynchronous signals via a channel.", "The point-to-point connection may further comprise a receiver (RX) associated with the second IP block, the RX comprising one or more DI decoders, and configured to receive the one or more DI asynchronous signals via the channel and restore the one or more compressed DI asynchronous signals to form a representation of the input data signals compliant to an input data format of the second IP block; and wherein the channel is a timing independent channel between the first IP block and the second IP block, wherein the one or more DI asynchronous signals from the TX are propagated via the timing independent channel in a self-timed fashion to the RX.", "According to various aspects, there is provided a point-to-multipoint connection between a first intellectual property (IP) block and a plurality of IP blocks.", "The point-to-multipoint connection may comprise a transmitter (TX) associated with the first IP block, the TX comprising one or more delay insensitive (DI) encoders and one or more temporal compressors, and configured to transform input data signals from the first IP block into temporally compressed DI asynchronous signals.", "The a point-to-multipoint connection may further comprise a timing independent channel between the TX and a Flow Control block, wherein the DI asynchronous signal from the TX is propagated via the timing independent channel in a self-timed fashion to the Flow Control block; the Flow Control block comprising a quasi-delay-insensitive (QDI) Flow Control element configured to broadcast or selectively propagate the compressed DI asynchronous signals to a plurality of individual timing independent channels; and multiple receivers (RXs) associated with receiving IP blocks, each RX comprising one or more DI decoders and one or more temporal decompressors, and configured to receive the DI asynchronous signals from the Flow control block and restore the compressed DI asynchronous signals received from the the Flow Control block to form duplicates of the input data signals.", "According to various aspects, there is provided a multipoint-to-point connection between a transmitting Intellectual Property (IP) block and a plurality of receiving IP blocks.", "The multipoint-to-point connection may comprise a plurality of transmitters (TXs) each associated with respective transmitting IP blocks, each TX comprising one or more delay insensitive (DI) encoders and one or more temporal compressors, and configured to transform input data signals received from the transmitting IP blocks into temporally compressed DI asynchronous signals.", "The multipoint-to-point connection may further comprise a plurality of timing independent channels between the TXs and individual inputs of a Flow Control block, wherein the compressed DI asynchronous signals from the TXs are propagated via timing independent channels in a self-timed fashion to the Flow Control block; the Flow Control block comprising a QDI Flow Control element configured to merge or selectively propagate the individual timing independent channels; anda receiver (RX) associated with the receiving IP block, the RX comprising one or more DI decoders and one or more temporal decompressors, and configured to restore the compressed DI asynchronous signal received from the Flow Control block to form duplicates of the input data signals.", "According to various aspects, there is provided a multipoint-to-multipoint connection between a plurality of transmitting IP blocks and a plurality of receiving IP blocks.", "The multipoint-to-multipoint connection may comprise a plurality of transmitters (TXs) each associated with a respective one of the transmitting IP blocks, each TX comprising one or more delay insensitive (DI) encoders and one or more temporal compressors, and configured to transform input data signals from the IP block into temporally compressed DI asynchronous signals.", "The multipoint-to-multipoint connection may further comprise timing independent channels between the TXs and individual inputs of a Flow Control block, wherein the DI asynchronous signals from the TXs are propagated via the timing independent channels in a self-timed fashion to the Flow Control block; the Flow Control block comprising a QDI Flow Control element configured to merge or selectively propagate the DI asynchronous signals to the individual timing independent channels; the QDI Flow Control element further configured to broadcast or selectively propagate the DI asynchronous signals to the individual timing independent channels; and multiple receivers (RXs) associated with the receiving IP blocks, each RX comprising one or more DI decoders and one or more temporal decompressors, and configured to receive the compressed DI asynchronous signals via the individual timing independent channels and restore the compressed DI asynchronous signal to form duplicates of the input data signals.", "Other features and advantages of the present inventive concept should be apparent from the following description which illustrates by way of example aspects of the present inventive concept.", "BRIEF DESCRIPTION OF THE DRAWINGS The above and other aspects and features of the present inventive concept will be more apparent by describing example embodiments with reference to the accompanying drawings, in which: FIG.", "1 is a general block diagram illustrating a possible embodiment of a generic Chronos Channel implementation; FIG.", "2a is an example of a 2 bits Chronos Channel; FIG.", "2b is an example of a 4 bits Chronos Channel; FIG.", "2c is an example of a 6 bits Chronos Channel; FIG.", "2d is an example of an 8 bits Chronos Channel; FIG.", "3a represents a Chronos Robust flow graph; FIG.", "3b represents a Chronos Robust Low Power flow graph; FIG.", "3c represents a Chronos Dense flow graph; FIG.", "4a shows an exemplary Chronos Channel using Join or Merge blocks; FIG.", "4b shows an exemplary Chronos Channel using Fork or Steer blocks; and FIG.", "4c shows an exemplary Chronos Channel using Join, Merge, Fork and Steer blocks.", "FIG.", "5 is a flowchart illustrating a process for ASIC design according to various embodiments; FIG.", "6 is a flowchart illustrating a process for gasket generation according to various embodiments; and FIG.", "7 is a block diagram illustrating a wired or wireless system according to various embodiments.", "DETAILED DESCRIPTION While certain embodiments are described, these embodiments are presented by way of example only, and are not intended to limit the scope of protection.", "The methods and systems described herein may be embodied in a variety of other forms.", "Furthermore, various omissions, substitutions, and changes in the form of the example methods and systems described herein may be made without departing from the scope of protection.", "A Chronos Channel is an ASIC Interconnect that allows transmitter blocks to send data to receiver blocks.", "Chronos Channels stand out by relying on a reduced set of timing assumptions and being robust against delay variations.", "To do so, Chronos Channels transmit data using delay insensitive (DI) codes and quasi-delay-insensitive (QDI) logic.", "In this way, Chronos Channels are insensitive to all wire and gate delay variations, but for those belonging to a few specific forking logic paths called isochronic forks.", "Also, a unique characteristic of a Chronos Channel, when compared to related solutions, is that it uses temporal compression in its internal paths to reduce the overheads of QDI logic and efficiently transmit data.", "In fact, data can be compressed by different ratios, which can be any rational number (as long as a technology specific maximum frequency restriction is respected).", "In this way, a Chronos Channel is defined by the combination of a DI code (and related handshake protocol), a temporal compression ratio and the hardware required to encode, decode, compress, decompress and transmit data.", "DI codes are a specific family of encoding schemes where no codeword can be contained in another codeword.", "This allows a receiver to perceive the transmission of a codeword unambiguously.", "Such a characteristic eliminates the need for a control signal that identifies the validity of a data channel, and its respective timing assumptions (as in synchronous or bundled-data asynchronous design), as the validity of the data channel is encoded in the data itself.", "Also, note that, usually, DI codes are employed in digital applications, which means that their code words are typically defined using a set of binary values.", "However, in a Chronos Channel, signals do not need to be digital and codewords can be represented using sets with more than 2 values, provided that data is still encoded using a DI code.", "In other words, the data in a Chronos Channel can be composed of analog signals, as long as no codeword is contained in another codeword.", "Such a characteristic allows a more flexible usage of Chronos Channels.", "Another aspect of DI codes is that, to allow data transmission, they are usually coupled to a handshake protocol, which is usually 4- or 2-phases.", "A large variety of DI codes are available in the state-of-the-art.", "One example of DI encoding schemes for Chronos Channels is the Chronos-Robust encoding scheme, a flowchart of which is illustrated in FIG.", "3a.", "In this scheme 300, the decoded data is represented by the set of symbols (a,b) and the encoded data by (A, B, C).", "For transmitting data using this encoding scheme, whenever codeword “A” 301 is detected in the channel, one can safely identify that a value “a” 303 is in the channel.", "The same is valid whenever a codeword “B” 304 is detected and one can safely identify a value “b” 305.However, to allow data transmission there is always the transmission of an empty codeword “C” 306 between every valid codeword (“A” or “B”).", "This allows a receiver to detect sequences of “A”s or “B”s unambiguously.", "In this case, a 4-phase handshake is established and the protocol for transmitting data is: (i) the sender issues a valid codeword; (ii) the receiver acknowledges the valid codeword; (iii) the sender issues a spacer; and (iv) the receiver acknowledges the spacer.", "As an example, one can have a 1 bit binary data (a=0, b=1) being encoded using 2 bits binary codewords (A=01, B=10, C=00).", "Note that, by using this scheme, one can safely identify transitions between “a” and “b”.", "As another example, one can have the same 1 bit binary data (a=0, b=1) being encoded using a single analog signal (A=0V, B=1V, C=0.5V).", "Another example of DI encoding scheme for a Chronos Channel is the Chronos-Robust Low Power encoding scheme, a flowchart of which is illustrated in FIG.", "3b.", "In this scheme, 310, decoded data is represented by (a,b) and encoded data by (A, B, C, D).", "For transmitting data using this encoding scheme, it is not enough to analyze the current codeword to detect the respective value.", "For example, codeword “A” 311 may represent either an “a” 312 or a “b” 314 value, depending if the previous codeword was “B” 315 or “C” 316, respectively.", "In this case, where one can only detect a value analyzing transitions, rather than codewords, a 2-phase handshake protocol is required: (i) the sender issues a new codeword; (ii) the receiver acknowledges the codeword; As an example, one can have a 1 bit binary data (a=0, b=1) being encoded using 2 bits binary codewords (A=00, B=01, C=10, D=11).", "Note that, by using this scheme, one can safely identify “a” values whenever there is a transition in the least significant bit of the codewords and “b” values whenever there is a transition in the most significant bit of the codewords.", "Compared to the Chronos Robust encoding scheme this encoding scheme reduces the number of transitions leading to lower switching power.", "A Chronos Robust Dense encoding scheme illustrated in FIG.", "3c is another DI encoding scheme, where decoded data is represented by the set (a,b,c,d) and encoded data by (A, B, C, D).", "In this encoding scheme 320, it is also not enough to analyze the current codeword to detect the respective value.", "In this encoding scheme a value is detected by analyzing transitions, rather than codewords.", "However, differently from the Chronos Robust Low Power example, data detection always requires 2 transitions, one to issue a pre-valid codeword (B 322 or C 323) and one to issue a valid codeword (A 321 or D 324).", "Therefore, a 4-phase handshake protocol is required: (i) the sender issues a new pre-valid codeword; (ii) the receiver acknowledges the pre-valid codeword; (iii) the sender issues a new codeword; and (iv) the receiver acknowledges the new codeword.", "As an example, one can have a 2 bit binary data (a=00, b=01, c=10, d=11) being encoded using 2 bits binary codewords (A=00, B=01,C=10, D=11).", "Note that, by using this encoding scheme, one can safely identify valid data such that: (i) “a”: whenever there is a transition to B followed by a transition to A; (ii) “b”: whenever there is a transition to C followed by a transition to A; (iii) “c”: whenever there is a transition to B followed by a transition to D; and (iv) “d”: whenever there is a transition to C followed by a transition to D. A possible application of the Chronos Robust Dense encoding scheme is data encryption or data correction.", "Chronos Channels do not have a global clock signal, hence their basic performance cannot be defined as an operating frequency, but rather as a cycle time.", "In such channels, the cycle time is defined as the time between two consecutive transactions when the Channel is always transmitting data.", "In other words, the cycle time of a Chronos Channel dictates how fast it can consume the data of a producer and how fast it will generate data to a consumer.", "For example, assuming that the cycle time of a Chronos Channel is fns, a producer can generate a new data every 1 ns (or operate at an equivalent frequency of 1 GHz) and safely assume that every new piece of data it generates will be consumed by the Chronos Channel.", "Similarly, in this case, a consumer can expect to receive a new data every 1 ns from the channel.", "Hence, it can also sample data at an equivalent frequency of 1 GHz.", "Note, however, that Chronos Channels do not have any assumption of possible clock signals used in producers and consumers connected to them, as they employ synchronizers in their control path interfaces.", "Another performance metric of a Chronos Channel is its latency, or the time it takes for data being available in its inputs to being transmitted to its outputs.", "Note that, depending on the spatial distribution of the Chronos Channel in the physical implementation of the circuit, its latency can grow, due to long wiring.", "Although it is unavoidable to increase the latency as the length of wires increase, the impact on cycle time can be mitigated (or even avoided) by adding repeater stages, which are like pipeline stages.", "In this way, a long link may exhibit an increased latency but cycle time can remain the same.", "In other words, it can take some cycles for the data to propagate through the Chronos Channel.", "However, the producer will still be able to inject new data at every cycle time and the consumer can still expect a new data at every cycle time.", "The notion of the cycle time and latency of a Chronos Channel is important to understand the different possibilities of temporal compression that can be adopted for these channels.", "In a Chronos Channel, the temporal compression ratio determines the number of slots in which a cycle time will be divided.", "This allows distributing temporally the data to be transmitted and reducing hardware overhead because the different slots can be propagated by sequentially using the same hardware.", "In other words, the temporal compression ratio defines how many pieces the data will be split into in order to be serially transmitted through the Chronos Channel.", "This ratio can be defined as any positive rational number and is only constrained by the maximum frequency allowed by a target technology.", "For example, assuming a cycle time of 1 ns, a compression ratio of 2 means that the data to be transmitted will be split in two pieces of data, each with a 0.5 ns slot of the total cycle time.", "In this way, the circuit implemented in the Chronos Channel needs to guarantee that each piece of data can be transmitted in 0.5 ns to ensure a 1 ns cycle time.", "Note that, for higher temporal compression ratios, this cycle time is reduced, in such a way that the maximum ratio possible is limited by the maximum ratio allowed by the target technology (or the minimum delay for a single slot).", "To implement a Chronos Channel in a target technology, different circuits can be employed.", "FIG.", "1 shows a block diagram of a possible embodiment of a generic Chronos Channel implementation with the general hardware organization, in various embodiments, to explore the functionality of these circuits.", "In this hardware organization 100 there are 5 main components: encoders (Enc) 111; temporal compressors (TC) 112; repeaters (RP) 130; temporal decompressors (TD) 122; and decoders (Dec) 121.An encoder 111 is responsible for transforming the input data (e.g., input data received from a producer IP block to be transmitted to a consumer IP block), which is represented using “m” wires, into encoded data that uses “k” wires and a specific DI code.", "A Chronos Channel requires “j” encoders 111, where “j” is the size of the input data divided by the size of the DI code of choice.", "Also, encoder blocks 111 may require input control signals to indicate the validity of the data in their inputs.", "A clock signal (clockA) can be used for synchronous data inputs and an enable signal (enableA) can be used to enable or disable data consumption in order to fulfil specific data transmission protocol requirements.", "These encoder blocks 111 also generate an output control signal to indicate when the Chronos Channel is full and cannot accept new data.", "Note that data in either the inputs or the outputs of an encoder 111 can be digital or analog.", "The TC 112 splits a “j” sized set of encoded data in “j/i” (or the temporal compression ratio) “i” sized sets of encoded data.", "Then, the TC 112 issues each of the “j/i” sets in its outputs, one at a time.", "To control the flow of this data, the handshake protocol defined by the choice of DI code is used.", "Note that the maximum time to transmit each of the “j/i” sets is the delay of the slot defined by the target cycle time divided by the compression ratio.", "In this way, and assuming that the remaining parts of the circuit will also be able to consume the data while guaranteeing cycle time performance, all the “j/i” sets will be sent in one cycle time.", "The outputs of the TC 112 can feed either a repeater 130 or the TD 122 directly.", "Also, note that in case “j/i” is not a natural number, but rather a positive rational number, the TC 112 will use only the required number of its outputs in the transmission of the last slots of data.", "Nevertheless, the division of the cycle time in slots will still be a natural number defined as the ceiling function of “j/i”.", "Repeaters 130 have memory elements and are capable of holding encoded data and sending it to a next repeater or the TD 122.To control the flow of this data, the handshake protocol defined by the choice of DI code is used.", "Furthermore, the maximum time to transmit each of the “j/i” sets is also the delay of the slot defined by the target cycle time divided by the compression ratio.", "Note that repeaters 130 may or may not be required in a Chronos Channel, as they are used to fix slot delay violations in long paths that fail to meet cycle time requirements or to improve signal strength.", "Also, note that different numbers of repeaters 130 may be required for the different outputs of a TC 112.This is valid because, in a Chronos Channel, there is no global control signal dictating how events flow through the data path.", "Rather, each path from an output of a TC 112 to the input of a TD 122 has an independent flow control.", "Again, the only restriction is the specified cycle time.", "The TD 122 merges “q/i” sets of encoded data, each with size “i”, in a single set of encoded data with size “q”.", "Then the TD 122 issues the whole “q” sized set in its outputs, which feed the decoder blocks 121.To control the flow of this data, the handshake protocol defined by the choice of DI code is used.", "In this circuit, the maximum time to consume each of the “q/i” sets is the delay of the slot defined by the target cycle time divided by its compression ratio.", "Note that, in some embodiments, TDs 122 can have a different compression ratio than that of the TC 112 and can generate sets with a different size from those originally consumed by the TC 112.This is particularly useful when connecting transmitters and receivers with different clock frequencies.", "Also, if the compression ratio of the TD 122 is a positive rational number, it will only use the required number of its inputs in the consumption of the last slots of data.", "The decoder 121 is responsible for transforming input encoded data, which is represented using “k” wires and a specific DI code, back to the original input data that used “m” wires.", "In various embodiments, the decoder 121 is configured to transform the input encoded data to form a representation of the data signals input to the encoders 111, the representation being compliant to an input data format of the consumer IP block.", "To decode data, a Chronos Channel needs “q” decoders, as defined in the compression ratio of the TD 133.A decoder block may also require input control signals to indicate that data in its outputs was successfully collected.", "To do so, a clock signal (clockB) can be used, for synchronous data outputs, and an enable signal (enableB) can be used to enable or disable the generation of new data in the outputs of the Chronos Channel, to fulfil specific data transmission protocol requirements.", "Furthermore, decoders 121 also generate an output control signal to indicate when they are empty, which means there is no data in the Chronos Channel to be consumed.", "Note that data in either the inputs or the outputs of a decoder 121 can be digital or analog.", "Another important concept in a Chronos Channel is the definition of TX and RX blocks.", "As FIG.", "1 shows, TX 110 is the block that comprises the encoders 111 and TC 112 of the channel and RX 120 is the block that comprises the decoders 121 and TD 122 of the channel.", "In this way, the control signals connected to the TX 110 (enableA, clockA and full) must be produced and consumed by the transmitter connected to the Chronos Channel, whenever applicable.", "This means that the clock connected to the TX 110 (clockA) must be the same clock connected to the transmitter, assuming that the transmitter is synchronous.", "The same is valid for the input and output control signals of the TX 110 (enableA and valid), they must be respectively produced and consumed by the transmitter.", "In a similar way, the control signals of the RX 120 (enableB, clockB and empty) must be produced and consumed by the receiver connected to the Chronos Channel.", "Due to the asynchronous communication between TX and RX blocks 110 and 120, a Chronos Channel can interface transmitters and receivers that operate at different frequencies and with different data bus widths (as the compression ratios can be different in the TX and RX blocks 110 and 120).", "However, to avoid data loss, it must be ensured that the receiver consumes data as fast as the producer generates new data.", "To do so, the output throughput must be greater or equal to the input throughput.", "More specifically, recalling FIG.", "1: FB*p≥FA*n, where FB is the frequency of clockB and FA is the frequency of clockA.", "The usage of controllers coupled to the TX 110 and RX 120 can enable avoiding the requirement of constrained frequencies between transmitter and receiver blocks.", "Such controllers must be able to implement a communication protocol using the control signals provided by the TX and RX blocks 110 and 120.Note that these signals allow implementing a variety of communication protocols, such as (and not limited to) handshake- or credit-based protocols.", "The coupling of controllers to a Chronos Channel generates what is called a Chronos Link, and enables leveraging the full flexibility of Chronos Channels.", "This is because transmitters and receivers connected to Chronos Links can be completely asynchronous to each other and communication may be established by a handshake procedure without any need to perform complex timing closure.", "An example of such an implementation is given in patent application Ser.", "No.", "15/344,420.FIG.", "2a is a block diagram of a 2 bits Chronos Channel illustrating a point-to-point connection 200 from a transmitter (TX 211) operating at 100 MHz and sending digital data with a width of 2 bits to a receiver (RX 212) operating at 100 MHz and receiving digital data with a width of 2 bits.", "The employed TX 211 block and the RX 212 block both have a temporal compression ratio of 1 and, therefore, their TC and decompressor blocks can be omitted.", "Furthermore, in this example, data within the Chronos Channel is encoded using a digital 1-of-4 DI code, and requires 4 wires for each 2 bits of decoded data.", "In this example, one repeater 213 is enough to guarantee throughput and signal strength requirements.", "FIG.", "2b is a block diagram of a 4 bits Chronos Channel illustrating a point-to-point connection 220 from a transmitter (TX 221) operating at 100 MHz and sending digital data with a width of 4 bits to a receiver (RX 222) operating at 200 MHz and receiving digital data with a width of 2 bits.", "To accommodate the discrepancy between the input and the output data widths while maintaining throughput, the TX 221 has a temporal compression ratio of 2 and the RX 222 has a temporal ratio of 1.In this example, data within the Chronos Channel is also encoded using a digital 1-of-4 DI code, and requires 4 wires for each 2 bits of decoded data.", "Also, two repeaters 223 and 224 are used to guarantee throughput and signal strength requirements.", "Note that, because the compression ratio in the RX 222 is 1, a single decoder (Dec1) is used.", "However, because the compression ratio in the TX 221 is 2, the 4 bits input data is split in two 2 bits buses that are connected to 2 encoders 225 and 226 that generate data using a 1-of-4 DI code.", "The generated data is the input to a 2 to 1 TC 227 that issues the data of one input at a time in its output, which is also encoded using a 1-of-4 DI code.", "FIG.", "2c is a block diagram of a 6 bits Chronos Channel illustrating a point-to-point connection 240 from a transmitter (TX 241) operating at 100 MHz and sending digital data with a width of 6 bits to a receiver (RX 245) operating at 300 MHz and receiving digital data with a width of 2 bits.", "To accommodate the discrepancy between the input and the output data widths while maintaining throughput, the TX 241 has a temporal compression ratio of 3 and the RX 245 has a ratio of 1.Furthermore, this example demonstrates how TXs can be nested to allow more flexible and modular design of Chronos Channels, as the input data is divided in two buses, with widths of 4 and 2 bits.", "The bus of 4 bits is input to the nested TX 242, which can be the same implementation described in reference to TX 221 in FIG.", "2b.", "In this way, TX 242 encodes the data using a 1-of-4 DI code and divides it in two temporal slots, sending one at a time in its output.", "The TX 242 output is then connected to the first two inputs of the 3 to 1 TC 244 shown in FIG.", "2c.", "The third input of the TC 244 is connected to an encoder 243 that generates data using the same 1-of-4 DI codes used in the nested TX1 242.The TC 244 will then issue the three inputs one at a time to an output, which is directly connected to the RX 245.Note that in this example there is no need for repeaters between the TX and RX blocks.", "FIG.", "2d is a block diagram of an 8 bits Chronos Channel illustrating a point-to-point connection 250 from a transmitter (TX 251) operating at 100 MHz and sending digital data with a width of 8 bits to a receiver (RX 259) operating at 100 MHz and receiving digital data with a width of 8 bits.", "In this example, the TX 251 and RX 259 have the same throughput, requiring the same temporal compression ratio (in this case 4).", "Also, this example shows how TCs and decompressors can be arranged in tree structures, as they are associative.", "In the TX block 251, 4 encoders (End, Enc2, Enc3 and Enc4) encode data using a 1-of-4 DI code and two pairs of encoders, with each pair of encoders being connected to one of two 2 to 1 TCs 252 and 253.The TCs 252 and 253 are then connected to another TC 254.In this example, a single repeater 255 between the TX 251 and RX 259 blocks is used to fulfil throughput requirements.", "In the RX 259, TDs 256, 257 and 258 are organized in a tree structure where a single 1 to 2 TD 256 has its outputs connected to two other TDs 257 and 258.These TDs 256, 257 and 258, in turn, are connected to 4 decoders (Dec1, Dec2, Dec3 and Dec4) to decode the 1-of-4 DI data back to 8 bits digital data.", "In various embodiments, the decoders Dec1, Dec2, Dec3 and Dec4 are configured to transform encoded data input to the decoders to form a representation of data signals generated by a producer IP block and input to the encoders Enc1, Enc2, Enc3 and Enc4, the representation being compliant to an input data format of the consumer IP block.", "FIG.", "4a shows a block diagram of an exemplary Chronos Channel using Join or Merge blocks in a multi-point-to-point connection 400 according to various embodiments.", "Referring to FIG.", "4a, in various embodiments, a multi-point-to-point connection 400 may serve as a connection between two producer IP blocks and a third consumer IP block.", "The producer IPs are connected to respective inputs of TXs 401 and 402 (and subsequently to inputs of two repeaters RPO and RP1 in this example), thereby generating two independent paths in the Chronos Channel.", "These paths can then be combined using a flow control block 403, which can be (but are not limited to) a merge, a join or a select component, depending of the control flow requirements.", "For example, a merge component combines the information of both paths into a single output path, while a select or a join component can arbitrate between paths using some control mechanism.", "The output of the control flow block 403 will be propagated to the inputs of an RX block 404 via a third repeater RP2 in this example.", "Note that repeaters RP0, RP1 and RP2 can be added in any point between TXs 401 and 402 and RX 404, including before and after the flow control block 403.FIG.", "4b shows a block diagram of an exemplary Chronos Channel using Fork or Steer blocks in a point-to-multi-point connection 420 according to various embodiments.", "Referring to FIG.", "4b, in various embodiments, the point-to-multi-point connection 420 may serve as a connection between a producer IP block and two consumer IP blocks.", "The producer IP is connected to an input of TX 421 (and a repeater RPO in this example) and the generated path in the Chronos Channel can be divided using a flow control block 422, which can be (but is not limited to) a fork or a steer component, depending on the flow control requirements.", "For example, a fork component sends the same input information to both output paths, while a steer component can arbitrate to send different input information to each of the output paths using some control mechanism.", "The outputs of the control flow block 422 are propagated to inputs of RX blocks 423 and 424.Note that repeaters RP0, RP1 and RP2 can be added in any point between the TX 421 and the RXs 423 and 424, including before and after the flow control block 422.FIG.", "4c shows a block diagram of an exemplary Chronos Channel using Join, Merge, Fork and Steer blocks illustrating a multi-point-to-multi-point connection 430 according to various embodiments.", "Referring to FIG.", "4c, in various embodiments, the multi-point-to-multi-point connection 430 may serve as a connection between a set of producer IP blocks and a set of consumer IP blocks.", "Each producer IP block is connected to one of j TXs (TX0, TX1 to TXj), each which generates an independent path in the Chronos Channel.", "These independent paths can then be combined using different combinations of flow control blocks and any number of repeaters (RP0 to RPh) to implement a specific functionality.", "The combined paths are received at another set of flow control blocks and forwarded via repeaters (RP0, RP1 to RPq in this example) to receivers RX0, RX1 to RXq.", "In the end of each path in the Chronos Channel, the RXs are interfaced with the consumer IPs.", "Note that between the TXs (TX0, TX1 to TXj) and the RXs (RX0, RX1 to RXq), different combinations of flow control blocks and repeaters can be employed, to fulfil functional and performance requirements.", "All the logic used to implement the components of a Chronos Channel must be QDI.", "This requirement is to ensure the robustness of such channels and to guarantee that synchronization and control of events inside a Chronos Channel are all performed asynchronously.", "This allows timing independent channels to be established between IP blocks in an ASIC design.", "In this way, timing closure for the ASIC design may be accomplished with simplified, top level checks.", "That is, testing each individual IP block in the ASIC design across all corners (i.e., PVT) obviates any complex timing margin evaluation for the ASIC design as a whole.", "In various embodiments, a timing independent channel between two or more IP blocks may include one or more repeaters, which can improve signal strength and throughput.", "In various embodiments, repeaters may be inserted on the basis of distance between IP blocks, which can be determined beforehand.", "Advantageously, a Chronos Channel included in an ASIC design renders the ASIC design insensitive to PVT variations and resilient to aging.", "Due to the absence of a clock, the ASIC design also consumes less power.", "The ASIC design also exhibits low electromagnetic interference (EMI) as a result of the self-timed nature of the circuits as well as low leakage.", "Consequently, the ASIC design may be especially ideal for large area ASICs where routing (i.e., of the clock signal) is difficult and significant effort is traditionally expended in synthesizing a clock tree to balance the skew across corners and modes of operation.", "In various embodiments, each IP block may be associated with a liberty (i.e., .lib) file describing the timing and power parameters for the block in a particular technology across a range of operation modes.", "Moreover, each IP block may also be associated with an abstract view, which contains the IP physical boundary as well as the location of each pin.", "A top level netlist may describe the connections between different IP blocks.", "In addition, information on different clock domains should also be available.", "The foregoing information may serve as inputs into a Chronos Channel generation process.", "FIG.", "5 is a flowchart illustrating a process 500 for ASIC design according to various embodiments.", "Referring to FIG.", "5, in various embodiments, the process 500 includes a physical design step 510.In various embodiments, the physical design step 510 may include partitioning 512, floorplanning 514, placement 516, gasket insertion 518, simplified routing 520, and simplified timing check 522.In various embodiments, gasket insertion 518 replaces clock tree synthesis, which could be performed as part of the physical design step in a conventional ASIC design flow (e.g., a conventional ASIC design flow).", "According to one exemplary embodiment, gasket insertion 518 communication between various IP blocks uses self-timed as opposed to synchronous signals.", "Gasket insertion 518 includes inserting one or more gaskets (i.e., a transmitter gasket and/or a receiver gasket) for each IP block in an ASIC design.", "The gaskets transform a signal between two IP blocks from a synchronous signal to an asynchronous self-timed signal with a handshake between the IP blocks.", "In various embodiments, simplified signal routing 520 replaces conventional signal routing.", "The gaskets afford independence from any timing constraints.", "Consequently, connections between various IP blocks may be easily established.", "One or more asynchronous buffers (Abufs) may be inserted as a repeater between distantly located IP blocks in order to improve signal strength and throughput.", "Nevertheless, Abufs are inserted based on the distance between IP blocks and not based on any process, voltage and temperature (PVT) conditions or operation mode variations.", "In various embodiments, simplified timing check 522 replaces timing closure, which may be performed as part of the physical design step in a conventional ASIC design flow.", "The use of gaskets obviates a substantial need to evaluate timing margins across PVT corners.", "Most PVT and operation mode variations are accounted for by the asynchronous protocol.", "In various embodiments, the simplified timing check 522 includes verification of a small subset (e.g., approximate 10%) of slow corners.", "In various embodiments, each IP block may be associated with a liberty (i.e., .lib) file describing the timing and power parameters for the block in a particular technology across a range of operation modes.", "Moreover, each IP block may also be associated with an abstract view, which contains the IP physical boundary as well as the location of each pin.", "A top level netlist may describe the connection between different IP blocks.", "In addition, information on different clock domains should also be available.", "The foregoing information may serve as inputs into a gasket generation process.", "FIG.", "6 is a flowchart illustrating a process 600 for gasket generation according to various embodiments.", "Referring to FIGS.", "5 and 6, in various embodiments, the process 600 may implement gasket insertion 518.In various embodiments, one or more point-to-point buses (e.g., one of the point-to-point connections 200, 220 or 240) and/or point-to-multi-point buses (e.g., the point-to-multi-point connection 420) and/or multi-point-to-point buses (e.g., the multi-point-to-point connection 400) and/or multi-point-to-multi-point buses (e.g., the multi-point-to-multi-point connection 430) are identified in an ASIC design (602).", "The maximum speed of a clock associated with each bus is determined (604).", "For example, buses may include output signals from one IP block to one or more other IP blocks.", "The maximum speed of the clock associated with each bus corresponds to a maximum equivalent speed in an asynchronous domain for a given technology (i.e., MSPD).", "As such, the MSPD for each bus is determined (606).", "A required number of dual-rail or 1-of-n QDI blocks (i.e., encoders and decoders) is determined based on the MSPD for each bus (608).", "The transmitter and receiver gaskets for each bus may include the same number of dual-rail or 1-of-n QDI blocks.", "In various embodiments, a dual-rail or 1-of-n QDI implementation guarantees delay insensitivity in the timing independent channels between IP blocks in the ASIC design.", "One or more asynchronous multiplexers may be inserted to multiplex low speed transmission bus outputs from the dual rail or 1-of-n QDI encoders (610).", "The multiplexing of low speed transmission buses alleviates congestion.", "Thus, the transmitter gasket for each bus may include a certain number of asynchronous multiplexers.", "As such, a corresponding number of de-multiplexers are inserted on the receiving side (612).", "The de-multiplexers de-multiplex the buses to its original speed.", "FIG.", "7 is a block diagram illustrating a wired or wireless system 550 according to various embodiments.", "Referring to FIGS.", "5, 6 and 7, the system 550 may be used to perform the process 600.In various embodiments, the system 550 may be a conventional personal computer, computer server, personal digital assistant, smart phone, tablet computer, or any other processor enabled device that is capable of wired or wireless data communication.", "A person having ordinary skill in the art can appreciate that other computer systems and/or architectures may be used without departing from the scope of the present inventive concept.", "The system 550 preferably includes one or more processors, such as processor 560.Additional processors may be provided, such as an auxiliary processor to manage input/output, an auxiliary processor to perform floating point mathematical operations, a special-purpose microprocessor having an architecture suitable for fast execution of signal processing algorithms (e.g., digital signal processor), a slave processor subordinate to the main processing system (e.g., back-end processor), an additional microprocessor or controller for dual or multiple processor systems, or a coprocessor.", "Such auxiliary processors may be discrete processors or may be integrated with the processor 560.The processor 560 is preferably connected to a communication bus 555.The communication bus 555 may include a data channel for facilitating information transfer between storage and other peripheral components of the system 550.The communication bus 555 further may provide a set of signals used for communication with the processor 560, including a data bus, address bus, and control bus (not shown).", "The communication bus 555 may comprise any standard or non-standard bus architecture such as, for example, bus architectures compliant with industry standard architecture (“ISA”), extended industry standard architecture (“EISA”), Micro Channel Architecture (“MCA”), peripheral component interconnect (“PCI”) local bus, or standards promulgated by the Institute of Electrical and Electronics Engineers (“IEEE”) including IEEE 488 general-purpose interface bus (“GPIB”), IEEE 696/S-100, and the like.", "The system 550 preferably includes a main memory 565 and may also include a secondary memory 570.The main memory 565 provides storage of instructions and data for programs executing on the processor 560.The main memory 565 is typically semiconductor-based memory such as dynamic random access memory (“DRAM”) and/or static random access memory (“SRAM”).", "Other semiconductor-based memory types include, for example, synchronous dynamic random access memory (“SDRAM”), Rambus dynamic random access memory (“RDRAM”), ferroelectric random access memory (“FRAM”), and the like, including read only memory (“ROM”).", "The secondary memory 570 may optionally include an internal memory 575 and/or a removable medium 580, for example a floppy disk drive, a magnetic tape drive, a compact disc (“CD”) drive, a digital versatile disc (“DVD”) drive, etc.", "The removable medium 580 is read from and/or written to in a well-known manner.", "Removable medium 580 may be, for example, a floppy disk, magnetic tape, CD, DVD, SD card, etc.", "The removable medium 580 is a non-transitory computer readable medium having stored thereon computer executable code (i.e., software) and/or data.", "The computer software or data stored on the removable medium 580 is read into the system 550 for execution by the processor 560.In alternative embodiments, secondary memory 570 may include other similar means for allowing computer programs or other data or instructions to be loaded into the system 550.Such means may include, for example, an external medium 595 and a communication interface 590.Examples of external medium 595 may include an external hard disk drive or an external optical drive, or and external magneto-optical drive.", "Other examples of secondary memory 570 may include semiconductor-based memory such as programmable read-only memory (“PROM”), erasable programmable read-only memory (“EPROM”), electrically erasable read-only memory (“EEPROM”), or flash memory (block oriented memory similar to EEPROM).", "The removable medium 580 and the communication interface 590 allow software and data to be transferred from the external medium 595 to the system 550.The system 550 may also include an input/output (“I/O”) interface 585.The I/O interface 585 facilitates input from and output to external devices.", "For example the I/O interface 585 may receive input from a keyboard or mouse and may provide output to a display.", "The I/O interface 585 is capable of facilitating input from and output to various alternative types of human interface and machine interface devices alike.", "The communication interface 590 allows software and data to be transferred between system 550 and external devices (e.g.", "printers), networks, or information sources.", "For example, computer software or executable code may be transferred to system 550 from a network server via communication interface 590.Examples of communication interface 590 include, for example, but not limited to, a modem, a network interface card (“NIC”), a wireless data card, a communications port, a PCMCIA slot and card, an infrared interface, and an IEEE 1394 fire-wire.", "The communication interface 590 preferably implements industry promulgated protocol standards, such as Ethernet IEEE 802 standards, Fiber Channel, digital subscriber line (“DSL”), asynchronous digital subscriber line (“ADSL”), frame relay, asynchronous transfer mode (“ATM”), integrated digital services network (“ISDN”), personal communications services (“PCS”), transmission control protocol/Internet protocol (“TCP/IP”), serial line Internet protocol/point to point protocol (“SLIP/PPP”), and so on, but may also implement customized or non-standard interface protocols as well.", "Software and data transferred via the communication interface 590 are generally in the form of electrical communication signals 605.In one exemplary embodiment, these electrical communication signals 605 are provided to the communication interface 590 via a communication channel 635.In one embodiment, the communication channel 635 may be a wired or wireless network, or any variety of other communication links.", "The communication channel 635 carries the electrical communication signals 605 and can be implemented using a variety of wired or wireless communication means including wire or cable, fiber optics, conventional phone line, cellular phone link, wireless data communication link, radio frequency (“RF”) link, or infrared link, just to name a few.", "Computer executable code (i.e., computer programs or software) is stored in the main memory 565 and/or the secondary memory 570.Computer programs can also be received via communication interface 590 and stored in the main memory 565 and/or the secondary memory 570.Such computer programs, when executed, enable the system 550 to perform the various functions of the present invention as previously described.", "In this description, the term “computer readable medium” is used to refer to any non-transitory computer readable storage media used to provide computer executable code (e.g., software and computer programs) to the system 550.Examples of these media include the main memory 565, the secondary memory 570 (including the internal memory 575, the removable medium 580, and the external medium 595), and any peripheral device communicatively coupled with the communication interface 590 (including a network information server or other network device).", "These non-transitory computer readable mediums are means for providing executable code, programming instructions, and software to the system 550.In one embodiment implemented using software, the software may be stored on a computer readable medium and loaded into the system 550 by way of the removable medium 580, the I/O interface 585, or the communication interface 590.In such an embodiment, the software is loaded into the system 550 in the form of electrical communication signals 605.The software, when executed by the processor 560, preferably causes the processor 560 to perform the inventive features and functions previously described herein.", "The system 550 also includes optional wireless communication components that facilitate wireless communication over a voice and over a data network.", "The wireless communication components comprise an antenna system 655, a radio system 645 and a baseband system 625.In the system 550, radio frequency (“RF”) signals are transmitted and received over the air by the antenna system 655 under the management of the radio system 645.In one embodiment, the antenna system 655 may comprise one or more antennae and one or more multiplexors (not shown) that perform a switching function to provide the antenna system 655 with transmit and receive signal paths.", "In the receive path, received RF signals can be coupled from a multiplexor to a low noise amplifier (not shown) that amplifies the received RF signal and sends the amplified signal to the radio system 645.In alternative embodiments, the radio system 645 may comprise one or more radios that are configured to communicate over various frequencies.", "In one embodiment, the radio system 645 may combine a demodulator (not shown) and modulator (not shown) in one integrated circuit (“IC”).", "The demodulator and modulator can also be separate components.", "In the incoming path, the demodulator strips away the RF carrier signal leaving a baseband receive audio signal, which is sent from the radio system 645 to the baseband system 625.If the received signal contains audio information, then baseband system 625 decodes the signal and converts it to an analog signal.", "Then the signal is amplified and sent to a speaker.", "The baseband system 625 may also receive analog audio signals from a microphone.", "These analog audio signals are converted to digital signals and encoded by the baseband system 625.The baseband system 625 also codes the digital signals for transmission and generates a baseband transmit audio signal that is routed to the modulator portion of the radio system 645.The modulator mixes the baseband transmit audio signal with an RF carrier signal generating an RF transmit signal that is routed to the antenna system 655 and may pass through a power amplifier (not shown).", "The power amplifier amplifies the RF transmit signal and routes it to the antenna system 655 where the signal is switched to the antenna port for transmission.", "The baseband system 625 may also be communicatively coupled with the processor 560.The processor 560 has access to main memory 565 and/or secondary memory 570.The processor 560 is preferably configured to execute instructions (i.e., computer programs or software) that can be stored in the main memory 565 or the secondary memory 570.Computer programs can also be received from the baseband system 625and stored in the main memory 565 or in secondary memory 570, or executed upon receipt.", "Such computer programs, when executed, enable the system 550 to perform the various functions of the present invention as previously described.", "For example, the main memory 565 may include various software modules (not shown) that are executable by processor 560.The accompanying claims and their equivalents are intended to cover such forms or modifications as would fall within the scope and spirit of the protection.", "For example, the example apparatuses, methods, and systems disclosed herein can be applied wireless communication devices incorporating HF and/or UHF RFID reader capabilities.", "The various components illustrated in the figures may be implemented as, for example, but not limited to, software and/or firmware on a processor, ASIC/FPGA/DSP, or dedicated hardware.", "Also, the features and attributes of the specific example embodiments disclosed above may be combined in different ways to form additional embodiments, all of which fall within the scope of the present disclosure.", "The foregoing method descriptions and the process flow diagrams are provided merely as illustrative examples and are not intended to require or imply that the steps of the various embodiments must be performed in the order presented.", "As will be appreciated by one of skill in the art the order of steps in the foregoing embodiments may be performed in any order.", "Words such as “thereafter,” “then,” “next,” etc.", "are not intended to limit the order of the steps; these words are simply used to guide the reader through the description of the methods.", "Further, any reference to claim elements in the singular, for example, using the articles “a,” “an” or “the” is not to be construed as limiting the element to the singular.", "The various illustrative logical blocks, modules, circuits, and algorithm steps described in connection with the embodiments disclosed herein may be implemented as electronic hardware, computer software, or combinations of both.", "To clearly illustrate this interchangeability of hardware and software, various illustrative components, blocks, modules, circuits, and steps have been described above generally in terms of their functionality.", "Whether such functionality is implemented as hardware or software depends upon the particular application and design constraints imposed on the overall system.", "Skilled artisans may implement the described functionality in varying ways for each particular application, but such implementation decisions should not be interpreted as causing a departure from the scope of the present invention.", "The hardware used to implement the various illustrative logics, logical blocks, modules, and circuits described in connection with the aspects disclosed herein may be implemented or performed with a general purpose processor, a digital signal processor (DSP), an application specific integrated circuit (ASIC), a field programmable gate array (FPGA) or other programmable logic device, discrete gate or transistor logic, discrete hardware components, or any combination thereof designed to perform the functions described herein.", "A general-purpose processor may be a microprocessor, but, in the alternative, the processor may be any conventional processor, controller, microcontroller, or state machine.", "A processor may also be implemented as a combination of receiver devices, e.g., a combination of a DSP and a microprocessor, a plurality of microprocessors, one or more microprocessors in conjunction with a DSP core, or any other such configuration.", "Alternatively, some steps or methods may be performed by circuitry that is specific to a given function.", "In one or more exemplary aspects, the functions described may be implemented in hardware, software, firmware, or any combination thereof.", "If implemented in software, the functions may be stored as one or more instructions or code on a non-transitory computer-readable storage medium or non-transitory processor-readable storage medium.", "The steps of a method or algorithm disclosed herein may be embodied in processor-executable instructions that may reside on a non-transitory computer-readable or processor-readable storage medium.", "Non-transitory computer-readable or processor-readable storage media may be any storage media that may be accessed by a computer or a processor.", "By way of example but not limitation, such non-transitory computer-readable or processor-readable storage media may include RAM, ROM, EEPROM, FLASH memory, CD-ROM or other optical disk storage, magnetic disk storage or other magnetic storage devices, or any other medium that may be used to store desired program code in the form of instructions or data structures and that may be accessed by a computer.", "Disk and disc, as used herein, includes compact disc (CD), laser disc, optical disc, digital versatile disc (DVD), floppy disk, and Blu-ray disc where disks usually reproduce data magnetically, while discs reproduce data optically with lasers.", "Combinations of the above are also included within the scope of non-transitory computer-readable and processor-readable media.", "Additionally, the operations of a method or algorithm may reside as one or any combination or set of codes and/or instructions on a non-transitory processor-readable storage medium and/or computer-readable storage medium, which may be incorporated into a computer program product.", "Although the present disclosure provides certain example embodiments and applications, other embodiments that are apparent to those of ordinary skill in the art, including embodiments which do not provide all of the features and advantages set forth herein, are also within the scope of this disclosure.", "Accordingly, the scope of the present disclosure is intended to be defined only by reference to the appended claims." ] ]
Patent_15876047
[ [ "Crystalline Semiconductor Growth on Amorphous and Poly-Crystalline Substrates", "A multilayer semiconductor structure including at least in part a substrate and an III-N film layer.", "The substrate's constant of thermal expansion being substantially matched to the III-N film's constant of thermal expansion.", "The multilayer semiconductor structure may also include a crystal matching layer that has a lattice constant that substantially matches the lattice of constant of the III-N film.", "By not relying on the substrate for lattice matching the III-N film, the multilayer structure allows greater flexibility in the selection of an applicable substrate." ], [ "1.A multilayer structure comprising: a semiconductor substrate; a seed layer comprising of silicon deposited above the semiconductor substrate; a graphitic crystal matching layer comprising carbon deposited above the seed layer; and a device layer formed above the graphitic crystal matching layer, wherein the semiconductor substrate has a coefficient of thermal expansion (CTE) substantially matching a CTE of the device layer.", "2.The multilayer structure of claim 1, wherein the seed layer defines crystal orientation and grain size of the graphitic crystal matching layer.", "3.The multilayer structure of claim 1, wherein the semiconductor substrate is not a single crystal substrate.", "4.The multilayer structure of claim 1, wherein the semiconductor substrate comprises oriented multi-crystalline material.", "5.The multilayer structure of claim 1, wherein the graphitic crystal matching layer has point defects throughout its surface.", "6.The multilayer structure of claim 1, wherein the device layer comprises one or more of the following materials: AlGaN, GaN, or InGaN 7.The multilayer structure of claim 5, further comprising a nucleation layer deposited on the graphitic crystal matching layer.", "8.The multilayer structure of claim 1, wherein the graphitic crystal matching layer comprises at least two layers of carbon.", "9.The multilayer structure of claim 8, wherein the graphitic crystal matching layer has point defects in a first layer of carbon, wherein the first layer of carbon is above all other layers of carbon.", "10.A method of creating a multilayer structure comprising: forming a seed layer comprising of silicon deposited above a semiconductor substrate; forming a graphitic crystal matching layer comprising carbon above the seed layer; and forming a device layer above the graphitic crystal matching layer, wherein the semiconductor substrate has a coefficient of thermal expansion (CTE) substantially matching a CTE of the device layer.", "11.The method of claim 10, wherein the seed layer defines crystal orientation and grain size of the graphitic crystal matching layer.", "12.The method of claim 10, wherein the semiconductor substrate is not a single crystal substrate.", "13.The method of claim 10, wherein the semiconductor substrate comprises oriented multi-crystalline material.", "14.The method of claim 10, wherein the graphitic crystal matching layer has point defects throughout its surface.", "15.The method of claim 10, wherein the device layer comprises one or more of the following materials: AlGaN, GaN, or InGaN 16.The method of claim 14, further comprising forming a nucleation layer deposited on the graphitic crystal matching layer.", "17.The method of claim 10, wherein the graphitic crystal matching layer comprises at least two layers of carbon.", "18.The method of claim 10, wherein the graphitic crystal matching layer has point defects in a first layer of carbon, wherein the first layer of carbon is above all other layers of carbon.", "19.The method of claim 10, initially forming the graphitic crystal matching layer on a metal surface using vapor phase deposition, wherein the metal surface is separate from the semiconductor substrate, seed layer, and device layer; mechanically removing the graphitic crystal matching layer from the metal surface; and depositing the graphitic crystal matching layer on the seed layer." ], [ "<SOH> BACKGROUND <EOH>Group III-Nitride (III-N) semiconductors such as AlN, Al GaN, GaN, and InGaN have become important materials for the production of Light Emitting Diodes (LEDs) and high power devices such as High-Electron-Mobility Transistors (HEMTs).", "Other III-Nitrides such as AlN and AlGaN are often included in device structures to mitigate mismatches in lattice and thermal expansion or as barrier or cladding layers in LEDs.", "Homoepitaxial growth of III-Nitrides has significant commercial limitations due to the absence of crystalline III-N substrates of reasonable cost and adequate size.", "Accordingly, heteroepitaxial growth methods have been developed wherein the III-Nitrides are grown on non-native substrates which are not well-matched to III-Nitride films in terms of crystal lattice dimensions or coefficient of thermal expansion (CTE).", "The mismatch between the substrate, also referred to as the growth template, and the III-N film results in undesirable defects in the films crystal structure and distortions such as bowing or cracking of the substrate/film stack.", "Current techniques for heteroepitaxy growth of III-N materials involve expensive processes while only partially mitigating defect generation resulting from lattice and CTE mismatch." ], [ "<SOH> BRIEF SUMMARY <EOH>Various embodiments of the invention seek to separate the CTE and lattice matching requirements for optimized III-Nitride growth by (1) creating a coefficient of thermal expansion match by providing a CTE-matched substrate and (2) creating a lattice-matched growth surface using a film or stack of films that create a crystalline lattice structure and/or lattice spacing.", "Embodiments of the present invention may be achieved, for example, by selecting a bulk material for a substrate having a coefficient of thermal expansion substantially matching that of GaN or other semiconductor film and being manufactured as a wafer-like substrate with sub-nanometer-scale surface finish and selecting a thin film material or material stack that can be induced to have a crystal lattice substantially matching that of GaN.", "The thin film material or material stack is deposited on the bulk material in such a way that the thin film crystal structure is achieved independently of the bulk materials structure or lack of structure.", "In one embodiment, the thin film crystalline layer or stack of layers establishes a crystal structure suitable for the nucleation and growth of III-Nitride films.", "Crystal quality can be further influence by adding seed layers, also known as underlayers, between the bulk substrate and the thin film stack.", "Seed layers can also be used to influence both crystal orientation and grain size of the thin film stack.", "In one embodiment, the substrate is chosen to be CTE matched to the GaN film, but the substrate is not a single crystal or oriented multi-crystalline material and does not provide a crystalline template for the GaN growth.", "Instead, an oriented crystalline template for the GaN is provided by the intermediate layers (e.g.", "thin film crystalline layer, seed layer etc.).", "In contrast with growth templates currently used in the art, embodiments of the invention do not rely on the structure of the bulk substrate to establish crystallinity.", "Crystallinity is established only in the thin film stack, with no required coincidence or crystal registry to the crystal lattice of the substrate.", "Consequently, the bulk material can be chosen based on CTE properties and suitability for mass production; opening the opportunity to use amorphous or low crystal quality poly-crystals with little to no crystalline orientation." ], [ "CROSS REFERENCE RELATED APPLICATIONS The present application is a continuation in part of application Ser.", "No.", "15/161,111 entitled “Crystalline Semiconductor Growth on Amorphous and Polycrystalline Substrates” filed May 20, 2016, which claims benefit under 35 USC 119 (e) of U.S.", "Provisional Application No.", "62/184,692 entitled “Power Devices and LED Architectures Enabled by Bulk Quality Seeded Growth of a Member in the Solid Solution of Al GaN-InGaN using Group III-Nitride Crystal Matching Layer (“CML”) film” filed Jun.", "25, 2015; and of U.S.", "Provisional Application No.", "62/233,157 entitled “Crystalline Semiconductor Growth on Amorphous and Poly-Crystalline Substrates” filed Sep. 25, 2015; the contents of which are incorporated herein by reference in their entirety.", "TECHNICAL FIELD The present invention is related to a multilayer semiconductor structure.", "BACKGROUND Group III-Nitride (III-N) semiconductors such as AlN, Al GaN, GaN, and InGaN have become important materials for the production of Light Emitting Diodes (LEDs) and high power devices such as High-Electron-Mobility Transistors (HEMTs).", "Other III-Nitrides such as AlN and AlGaN are often included in device structures to mitigate mismatches in lattice and thermal expansion or as barrier or cladding layers in LEDs.", "Homoepitaxial growth of III-Nitrides has significant commercial limitations due to the absence of crystalline III-N substrates of reasonable cost and adequate size.", "Accordingly, heteroepitaxial growth methods have been developed wherein the III-Nitrides are grown on non-native substrates which are not well-matched to III-Nitride films in terms of crystal lattice dimensions or coefficient of thermal expansion (CTE).", "The mismatch between the substrate, also referred to as the growth template, and the III-N film results in undesirable defects in the films crystal structure and distortions such as bowing or cracking of the substrate/film stack.", "Current techniques for heteroepitaxy growth of III-N materials involve expensive processes while only partially mitigating defect generation resulting from lattice and CTE mismatch.", "BRIEF SUMMARY Various embodiments of the invention seek to separate the CTE and lattice matching requirements for optimized III-Nitride growth by (1) creating a coefficient of thermal expansion match by providing a CTE-matched substrate and (2) creating a lattice-matched growth surface using a film or stack of films that create a crystalline lattice structure and/or lattice spacing.", "Embodiments of the present invention may be achieved, for example, by selecting a bulk material for a substrate having a coefficient of thermal expansion substantially matching that of GaN or other semiconductor film and being manufactured as a wafer-like substrate with sub-nanometer-scale surface finish and selecting a thin film material or material stack that can be induced to have a crystal lattice substantially matching that of GaN.", "The thin film material or material stack is deposited on the bulk material in such a way that the thin film crystal structure is achieved independently of the bulk materials structure or lack of structure.", "In one embodiment, the thin film crystalline layer or stack of layers establishes a crystal structure suitable for the nucleation and growth of III-Nitride films.", "Crystal quality can be further influence by adding seed layers, also known as underlayers, between the bulk substrate and the thin film stack.", "Seed layers can also be used to influence both crystal orientation and grain size of the thin film stack.", "In one embodiment, the substrate is chosen to be CTE matched to the GaN film, but the substrate is not a single crystal or oriented multi-crystalline material and does not provide a crystalline template for the GaN growth.", "Instead, an oriented crystalline template for the GaN is provided by the intermediate layers (e.g.", "thin film crystalline layer, seed layer etc.).", "In contrast with growth templates currently used in the art, embodiments of the invention do not rely on the structure of the bulk substrate to establish crystallinity.", "Crystallinity is established only in the thin film stack, with no required coincidence or crystal registry to the crystal lattice of the substrate.", "Consequently, the bulk material can be chosen based on CTE properties and suitability for mass production; opening the opportunity to use amorphous or low crystal quality poly-crystals with little to no crystalline orientation.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1A is a cross sectional view of a multilayer semiconductor structure, in accordance with one exemplary embodiment of the present invention.", "FIG.", "1B is a cross sectional view of a multilayer semiconductor structure, in accordance with one exemplary embodiment of the present invention.", "FIG.", "1C is a cross sectional view of a multilayer semiconductor structure, in accordance with one exemplary embodiment of the present invention.", "FIG.", "1D is a cross sectional view of a multilayer semiconductor structure, in accordance with one exemplary embodiment of the present invention.", "FIG.", "1E is a cross sectional view of a multilayer semiconductor structure, in accordance with one exemplary embodiment of the present invention.", "DETAILED DESCRIPTION The various embodiments are described more fully with reference to the accompanying drawings.", "These example embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to readers of this specification having knowledge in the technical field.", "Like numbers refer to like elements throughout.", "FIG.", "1E illustrates a cross-section view of multilayer structure 100.Multilayer structure 100 includes several layers including: substrate 101, isolation layer 103, seed layer 105, crystal matching layer 107, nucleation layer 109, and III-N film 111.III-N film is a layer of semiconductor material consisting of at least one group III nitride material and/or their alloys (e.g.", "GaN, InN, AlGaN, InGaN).", "In some embodiments one or more layers 103, 105, 109, and 111 may be optional.", "Although, embodiments of the present invention are described below with reference to an III-N film, it is understood that any semiconductor film may be used by adjusting crystal matching layer 107 to accommodate the lattice parameter of the chosen semiconductor film.", "The process of forming multilayer structure 100 is described with relation to FIGS.", "1A-1E.", "Now with reference to FIG.", "1A, multilayer structure 100 includes, in part isolation layer 103 deposited via physical layer deposition (PVD) or chemical vapor deposition (CVD) on substrate 101.Depending on various applications, substrate 101 includes, in part a semiconductor material, a compound semiconductor material, or other type of material such as a metal or non-metal.", "For example, the materials comprising substrate 101 may include: molybdenum, molybdenum-copper, poly-aluminum nitride ceramic, mullite ceramic, alumina, sapphire, refractory nitrides of Zr(ZrN), Ti (Ti-N), Hf (HFN) or any alloy therein, graphite, aluminum-oxynitrides, silicon, silicon carbide, zinc oxides and rare earth oxides, and/or other suitable materials.", "In some embodiments, substrate 101 has a thickness in the range of 250 microns to 1 mm.", "Depending on various applications and material composition, substrate 101 may take different structural forms.", "For example, substrate 101 may include an amorphous or polycrystalline structure.", "However, in other embodiments, substrate 101 may include a single crystal (e.g.", "sapphire and silicon) or oriented multi-crystalline material.", "Regardless of the material or the structure, substrate 101 has a coefficient of thermal expansion (CTE) substantially matching the CTE of III-N film 111.In accordance with one embodiment of the present invention, substrate 101 for the multilayer structure 100 may be chosen for its CTE properties, and there may be no reliance on the underlying crystal structure of the substrate.", "As a result, substrate 101 may include any material so long as substrate 101 has a CTE (ppm per degree Kelvin or 10̂−6/K) that substantially matches the III-N film 111.Instead of depending on substrate 101 for providing a crystal structure or template for III-N film 111 growth, the crystal matching layer 107 may completely replace, upgrade, or enhance the crystal structure of substrate 101 and directly enable III-N film 111 growth.", "What is considered a substantially matched CTE depends on the application of the multilayer structure 100.In accordance with one embodiment, the substrate's CTE is within ±5% of the III-N film's CTE to be substantially matching.", "For example, in order for a substrate to be substantially matched with GaN (having an approximate CTE of 5.6), the substrate has a CTE between 5.32 and 5.88.The CTE of molybdenum is approximately 5.4, and according to one embodiment, is substantially matched to the CTE of GaN.", "Applications in power semiconductor discrete devices, GaN based integrated circuits (IC), or high current density optoelectronic devices; of which creating significant thermal stresses during fabrication of semiconductor device layer on the substrate would benefit from a substantial match in CTE in accordance with one embodiment.", "On the other hand, a silicon substrate with an approximate CTE of 2.6, would not be substantially matched to the CTE of the GaN film according to one embodiment.", "According to one embodiment, other materials that substantially match GaN include but are not limited to: Zirconium, Molybdenum, pure Arsenic, ZrTi (86:14 atomic percent), Carbide, and multigrained or polycrystalline Aluminum Nitride ceramic (1 to 1 atomic ratio).", "In one embodiment, a substrate's CTE substantially matches the III-N film's CTE if the substrate's CTE is within 1 unit (where 1 unit is a ppm per degree Kelvin) of the III-N film's CTE.", "In accordance with this embodiment, materials that substantially match GaN include, but are not limited to: Zirconium, Osmium, Hafnium, Chromium, Molybdenum, Cerium, Rhenium, Tantalum, Iridium, Ruthenium, Tungsten, Praseodymium, Germanium, InAs, InP, InSb, AlAs, AlP, GaP, GaAs, pure Arsenic, Molybdenum-Copper, alloys of ZrTi, alloys of HfTi, Carbide, and poly-Aluminum Nitride ceramic (1 to 1 atomic ratio), Titanium, alloys of Molybdenum, alloys of Tungsten, alloys of Nickel, alloys of Niobium, alloys of Iridium, Kovar, alloys of Neodymium, Molybdenum-Copper, metal alloys of Ti, alloys of Zr, alloys of Hf, Carbide, poly-Aluminum Nitride ceramic of varying atomic proportions, alumina ceramic, titania, polycrystalline SiC.", "Typical applications requiring a substantially matched CTE according to this embodiment include, but are not limited to, thermal annealing, thermal degas or cleaning steps, physical or chemical film growth, recrystallization steps, metal contact firing steps, implantation and subsequent annealing, or any circuit fabrication steps (mask/lithography, growth, etch/pattern, metallization, CMP, etc) that may require temperature heat up/cool down steps in any portion of the range of 1400 Celsius to room temperature and must remain below 50 microns of substrate or wafer bow over any wafer diameter.", "In another embodiment, a substrate's CTE substantially matches the III-N film's CTE if the substrate's CTE is within 0.5 unit (where the unit is a ppm per degree Kelvin) of the III-N film's CTE.", "For example, molybdenum has a CTE of approximately 5.4, which is within 0.5 of the CTE (unit of ppm per degree Kelvin) of GaN.", "In accordance with this embodiment, other materials that substantially match GaN include, but are not limited to: Molybdenum, pure Arsenic, Chromium, ZrTi (86:14), Carbide, Germanium, Osmium, Zirconium, Hafnium, InSb, Kovar, and poly-Aluminum Nitride ceramic (1 to 1 atomic ratio).", "Typical applications requiring a substantially matched CTE according to this embodiment include, but are not limited to: thermal annealing, thermal degas or cleaning steps, physical or chemical film growth, recrystallization steps, metal contact firing steps, implantation and subsequent annealing, or any circuit fabrication step (mask/lithography, growth, etch/pattern, metallization, CMP, etc.)", "that requires temperature heat up/cool down steps in any portion of the range of 1400 Celsius to room temperature, and must remain below 25 microns of substrate or wafer bow over any wafer diameter.", "It is known that differences in CTE between a film and substrate can lead to residual stress between the film and the substrate as a result of heating and cooling processes during film deposition.", "Residual stress may result in compression or tension on the film.", "When the film compresses, the residual stress may be relieved by buckling of the film, but when the film is under tension, the residual stress may be relieved by cracking of the film.", "In one embodiment, in the case of a CTE mismatch between the film and the substrate that results in residual stress, the multilayer structure 100 should be designed to create compression on III-N film 111 rather than tension on III-N film 111.Moreover, maintaining wafer flatness is crucial to manufacture devices from the deposited GaN film(s) on the substrates.", "For any film thickness of GaN grown on a substrate where the film thickness is less than the substrate thickness, Table 1 enumerates designs that would be allowed assuming increasing substrate diameter and corresponding thickness to achieve two categories of tolerable bow or warp, namely less than 25 microns and lower than 50 microns (limits mainly set by automatic handling equipment and limits in depth of focus for lithographic steps).", "TABLE 1 Extrinsic Strain Delta CTE allowed @ Assumed allowed by 1400 C. Calculated Thickness Diameter CTE Match matching cool down max Bow Curvature (micron) (nam) Range (ppm/C) cycle (micron) (1/km) 675 150 +/−5% 0.28 −0.000385 3.21 1.14 725 200 +/−5% 0.28 −0.000385 5.31 1.06 825 300 +/−5% 0.28 −0.000385 10.50 0.93 675 150 +/−0.5 0.5 −0.0006875 5.73 2.04 725 200 +/−0.5 0.5 −0.0006875 9.48 1.90 825 300 +/−0.5 0.5 −0.0006875 18.75 1.67 675 150 +/−1.0 1.0 −0.001375 11.46 4.07 725 200 +/−1.0 1.0 −0.001375 18.97 3.79 825 300 +/−1.0 1.0 −0.001375 37.50 3.33 To remain below 50 microns of bow or warp any wafer diameter and any of the 3 ranges of CTE matching can be used (+/−5% of value, +/−0.5, and +/−1.0 about the value of GaN).", "Similarly to remain below 25 microns of bow or warp all wafer diameters are allowed for all 3 ranges of CTE matching with the exception of 300 mm for +/−1.0 ppm about the GaN value.", "This latter condition could be reached if wafer thickness is allowed to increase by industry standards to 1200 mm (<25 microns bow for a +/−1 ppm delta in CTE compared to GaN on 300 mm diameter).", "As previously stated, the isolation layer 103 is deposited on substrate 101 by any suitable PVD or CVD process (e.g.", "Plasma-enhanced chemical vapor disposition (PECVD), Low-pressure chemical vapor deposition (LPCVD), Atomic layer deposition (ALD), Plasma Torch, Liquid phase epitaxy (LPE), and spin coat annealing) In some embodiments, the thickness of the isolation layer 103 is in the range of 1.0 nm (1 nm=1 nanometer=1×10−9 m) to 500 nm.", "In one embodiment, the isolation layer 103 is deposited via a spin on coat technique from a liquid and annealed to achieve a smooth film.", "The isolation layer 103 may serve as a smooth and non-reacting surface for subsequent layers.", "The isolation layer 103 may be also used to prevent subsequent layers from replicating an undesirable crystal structure that may be found in substrate 101, resetting the crystalline orientation and setting a new growth axis.", "Materials that could be used in the isolation layer 103 would have one or more of the following function(s) and properties: amorphous or lack of crystal structure, be deposited as non-conformal films, low stress, and the capability to fill in high aspect ratio morphology such as pits, grooves, or ledges.", "For example, glasses, glassy carbon, metal nitrides, oxy-nitrides, and oxides such as SiO2 are examples of materials that can be included in the isolation layer 103.In some embodiments, where the substrate has a desirable crystal structure isolation layer 103 may be omitted from structure 100.In one embodiment, isolation layer 103 includes silicon dioxide or silicon nitride.", "In some embodiments, isolation layer 103 includes multiple layers followed by a chemical mechanical polish to achieve sufficient flatness, in the range of <5 nm rms surface roughness on areas of 25 um×25 um.", "Now with reference to FIG.", "1B, seed layer 105 is deposited on isolation layer 103.Seed layer 105 includes, in part one or more thin film layers deposited on top of each other (i.e.", "in a stack) by any known CVD or PVD process.", "In some embodiments, the thickness of the seed layer 105 is in the range of 1 atomic layer to 500 nm.", "Seed layer 105 defines crystal orientation, crystal polarity, crystal structure type, and/or grain size for crystal matching layer 107 and may consist of multiple layers.", "In one embodiment, the seed layer 105 includes, in part at least one or more of the following materials: carbon, iron, chromium, titanium, cobalt, ruthenium, tantalum, nickel, and molybdenum.", "In one embodiment, seed layers will be grown using PVD techniques and will be grown at appropriate temperatures and target power to achieve dense films.", "In the case of wurtzite structure films, the c-axis will be normal to the growth plane, and in the case of cubic crystals, the 111 axis will be normal to the growth plane.", "For example, a first layer in seed layer 105 includes titanium (Ti) and may be used to lower the surface energy of substrate 101 in order to improve the growth of subsequent layers by thermodynamically favoring the (0001) direction to be normal to the plane.", "In another example, substrate 101 is an aluminum nitride ceramic wafer and seed layer 105 is a thin film layer of cobalt, which together establish a hexagonal close packed (HCP) structure with the c-axis perpendicular to substrate 101.The HCP structure created by seed layer 105 influences the crystal orientation of the subsequent crystal matching layer 107.In other embodiments, seed layer 105 may be used to form a face center cubic (FCC) structure, HCP, or a body centered cubic (BCC) structure, which allows the crystal matching layer 107 to grow with the HCP crystal structure.", "Stated another way, the seed layer 105 does not have to be a matched crystal structure to the crystal matching layer 107; instead the seed layer 105 is an appropriate crystal structure.", "In some embodiments where substrate 101 presents a suitable crystal structure, both isolation layer 103 and seed layer 105 may be omitted from multilayer structure 100.Examples of such substrates could include ZrTi, Molybdebdum, HfTi, c-oriented polycrystalline Aluminum Nitride, and c-oriented poly-crystalline SiC, materials with CTE within +/−5% about the value of GaN.", "With reference to FIG.", "1C, crystal matching layer 107 is deposited on seed layer 105.The crystal matching layer may be deposited on seed layer 105 using any known and suitable PVD or CVD method.", "Because, substrate 101 is selected due to its CTE qualities in relation to III-N film 111, there may exist lattice constant mismatch between substrate 101 and III-N film 111.In particular, the lattice mismatch can be extremely different, and may be greater than the 13% typically sought for heteroepitaxy.", "Embodiments of the invention allow for independently matching the CTE of substrate 101 and III-N film 111 without regard to the lattice parameter of substrate 101 of multilayer structure 100.The crystal matching layer 107 includes, in part one or more metal layers that accommodate and/or eliminate the lattice constant mismatch between substrate 101 and III-N film 111.The thickness of crystal matching layer 107 ranges between 5 nm and 1000 nm.", "In one embodiment, the crystal matching layer includes, in part two or more constituent elements, for example two constituents includes, in part a first chemical element and a second chemical element to form a constituent element alloy.", "The constituent elements may have similar crystal structures at room temperature, such as an HCP structure.", "In addition to crystal structures, the constituent elements may have similar chemical properties.", "In one embodiment, the first and second chemical elements may both belong to group four elements (e.g.", "titanium (Ti), zirconium (Zr), hafnium (Hf) and rutherfordium (Rf)), alloys of the group four elements, nitrides of the group four elements, and the alloys further alloyed with the elements of tantalum (Ta), boron (B), silicon (Si), and the crystal matching layer 107 is capped with the nucleation layer 109.The constituent element alloy may include a third chemical element or more elements which have similar crystal structures and similar chemical properties.", "The different chemical elements and the proportions of those chemical elements that make up the constituent element alloy(s) of crystal matching layer 107 may be modified to substantially match the lattice constant of III-N film 111.According one embodiment, ranges for substantial match for heteroepitaxy to mimic homo-epitaxy and do not form crystal misfit and dislocation defects is within the range of +/−1-3% of the value of the III-N film layer's lattice constant (layer 111).", "The process of selecting and proportion these chemical elements is further described in U.S. patent application Ser.", "No.", "8,956,952 and U.S. patent application Ser.", "No.", "14/106,657.By utilizing crystal matching layer 107, potential residual stress, along with point and extended defects such as crystal misfit and threading dislocation, may all together be lowered or completely removed which might otherwise occur in III-N film 111 as a result of the difference in the lattice constants between substrate 101 and III-N film 111.Substantially matching the lattice constants (i.e.", "+/−1-3%) of crystal matching layer 107 and III-N film 111 aids in the growth of the highest crystalline quality III-N film.", "In another embodiment, the crystal matching layer 107 may comprise of a glassy carbon, graphene carbon, graphitic carbon, or pyrolyzed carbon, diamond carbon, and diamond-like coatings that has been purposefully “peppered” with point defects throughout the surface of the film.", "The term “graphitic crystal matching layer” and like terms refers to an embodiment where crystal matching layer 107 comprises may comprise of a glassy carbon, graphene carbon, graphitic carbon, or pyrolyzed carbon, diamond carbon, and diamond-like coatings that has been purposefully “peppered” with point defects throughout the surface of the film.", "The graphitic crystal matching layer 107 is comprised of >2 carbon layers (e.g.", "2, 3, 4, 5), wherein the point defects are introduced in the topmost layer of carbon atoms.", "A point defect is created by a displacing an atom from its equilibrium lattice position.", "In one embodiment, graphitic crystal matching layer 107 is initially grown on low cost metal such as copper metal, or SiC wafer, or SiC coating on Si wafer, forming graphene from the decomposition of a methane or acetylene gas, or other carbon containing gas using a vapor phase deposition.", "The carbon grows as graphene sheets, 1 to 5 carbon layers thick, and can be mechanically released using a thermal anneal tape or direct wafer to wafer contact transfer method, and subsequently transferred by direct application to seed layer 105 (or any other suitable layer.)", "Once the graphitic crystal matching layer 107 is transferred to multilayer structure 100 the tape or the carrier substrate of the graphitic crystal matching layer 107 is released by reheating to temperatures above 250 C and cooling down to room temperature.", "In a second embodiment, a positive photoresist (PR) is spun directly onto seed layer 105 and then annealed at temperatures >1000C in inert gas annealing chamber or under high vacuum, resulting in benzene rings in the PR to form hexagonal graphene or graphitic carbon as the volatile organic compounds are evaporated from the PR.", "Thus the PR becomes graphitic or graphene and acts as the graphitic crystal matching layer.", "The ability to use graphene comes about due to the satisfied sp2 bonds associated with graphene, which in turn does not provide chemically reactive sites for traditional epitaxial growth that rely on covalent bonding out of the plane of the film on the graphene.", "Instead, the first layer of atoms from nucleation layer 109 is attracted to the outermost layer of atoms from graphitic crystal matching layer 107 owing to the point defects, otherwise uniform film formation would not arise without the point defect strategy.", "State another way, without point defects in graphitic crystal matching layer 107 subsequent layers cannot be uniformly grown on graphitic crystal matching layer 107.This means no electrons transfer and no significant lattice mismatch can form, with III-N film 111 if one can nucleate the III-N film 111 (e.g.", "AlGaN, GaN, InGaN) on the graphene, the only bonds of significance that determine strain are the cohesive ones within the III-N film 111 itself.", "Stated another way, the graphene or graphitic crystal matching layer 107 interface with substrate 101 consists of van der Waals bonds only, which allows for completely relaxed growth of III-N film 111 at its unstrained lattice parameters, producing a compliant interface.", "Furthermore, graphene allows for the growth of high quality III-N films since III-N film 111 does not initiate with strain.", "Because of the lack of strain there is no buildup as the film grows to a given thickness as is traditionally the case with heteroepitaxy of dissimilar materials.", "The cause for a film to form defects is the buildup of strain leading to stress which is released by forming extended defects after a critical thickness is reached.", "By utilizing van der Waals nucleation, defects which are typically generated due to this strain have no driving force to form.", "In other words, when using a graphene or graphitic crystal with sp2 bonding within the plane and no out of plane bonds for the crystal matching layer 107, requiring the addition of point defects by plasma exposure or other energetic bombardment prior to growth of nucleation layer 109, III-N film 111 film grows unstrained to underlying substrate 101 which paves the way for very high structural and crystalline quality film to grow with its equilibrium lattice constants.", "In one embodiment, crystals in the range of 3.1 Angstroms to 4.5 Angstroms can grow “relaxed” and without mismatch, as they are accommodated to float via van der Waal interaction.", "In another embodiment, the graphitic crystal matching layer 107 is a thermal conductive layer in the range of 1000 to 2000 Watts/meter*Kelvin (W/m*k), enabling heat to be removed from this layer that is in in the range 20× to 40× more thermally conductive than the substrates or the GaN itself.", "Thus, for example, the graphitic crystal matching layer 107 would allow a transistor that operates at 250 C to run at 100 C for example.", "Typical conductivity of polycrsytalline AlN is about 150-180 W/mK, Si and GaN are approximately 50 W/mK.", "Thus, the graphitic crystal matching layer 107 operation as a heat sink would be a big advantage over traditional heat sinks in the semiconductor field.", "Now with reference to FIG.", "1D, nucleation layer 109 is deposited on the crystal matching layer 107.The nucleation layer 109 may be deposited by any suitable PVD or CVD process.", "The nucleation layer provides a surface that is chemically and physically compatible with III-N film 111.Nucleation layer 109 also provides a suitable growth environment (i.e.", "chemistry, crystal polarity, and symmetry) for growing III-N film 111.In some embodiments, nucleation layer 109 includes, in part a nitride film (e.g.", "aluminum nitride (AlN)).", "In one embodiment, nucleation layer 109 is deposited in the range of 1.0 nm to 200 nm and is pseudomorphically grown to maintain the lattice of the crystal matching layer 107.The nucleation layer 109 may be pseudomorphically (with the same lattice parameter of crystal matching layer 107) grown aluminum nitride (AlN), aluminum gallium nitride (AlGaN), gallium nitride (GaN), indium gallium nitride (InGaN).", "In one embodiment, the nucleation layer 109 has the same lattice parameter as the crystal matching layer 107.With reference to FIG.", "1E, III-N film 111 is deposited on the nucleation layer 109.The III-N film may be epitaxial grown by any suitable PVD or CVD process.", "In one embodiment, the III-N film 111 is a semiconductor compound and a member of the solid solution gallium nitride (GaN) and its alloys with aluminum (Al), indium (In), boron (B), including and not limited to: aluminum nitride (AlN), aluminum gallium nitride (AlGaN), gallium nitride (GaN), indium nitride (InN), indium gallium nitride (InGaN), and boron nitride (BN).", "A novel concept presented by the embodiments of the present invention is that by removing lattice mismatch and CTE mismatch independently using multilayer structure 100, for the first time there is no upper limit to the thickness of the III-N film 111 that can be grown.", "In an alternate embodiment III-N film 111 is deposited on the nucleation layer 109 or directly upon the crystal matching layer 107 by hydride Vapour Phase Epitaxy (HVPE).", "The use of HVPE for the epitaxial growth of the III-N semiconductor allows for the III-N semiconductor to grow cost effective high crystalline quality (thick) films.", "Typically, HVPE films can be grown from 10 microns to 1 mm in 1-3 hours, whereas the limitation in grow rates for conventional MOCVD limits grow to <10 microns, takes 10-20 hours to grow.", "In one embodiment, multilayer structure 100 includes the following layers: poly ALN substrate with a diameter of 200 mm and a thickness of 825 micron (101), spin on glass such as SiO2 with a thickness of 750 nm (103), tantalum seed layer with a thickness of 10 nm (105), ZrTi with a thickness of 1000 nm (107), AlN with a thickness of 200 nm (109), and device layers of GaN with a thickness of 1 micron to 50 micron (111).", "In another embodiment, multilayer structure includes the following layers: polycrystalline AlN ceramic substrate with a diameter of 200 nm and a thickness of 825 um (101), SiO2 layer with a thickness of 750 nm (103), graphene seed layer with a thickness of >2 atomic layers (107), AlN layer with a thickness of >10 nm (109), and a device layers of GaN with a thickness of 1 micron to 50 micron (111).", "Many modifications and other example embodiments set forth herein will bring to mind to the reader knowledgeable in the technical field to which these example pertain to having the benefit of the teachings presented in the foregoing descriptions and the associated drawings.", "Therefore, it is to be understood that the embodiments are not to be limited to the specific ones disclosed and that modifications and other embodiments are intended to be included within the scope of the claims.", "Moreover, although the foregoing descriptions and the associated drawings describe example embodiments in the context of certain example combinations of elements and/or functions, it should be appreciated that different combinations of elements and/or functions may be provided by alternative embodiments without departing from the scope of the appended claims.", "In this regard, for example, different combinations of elements and/or functions other than those explicitly described above are also contemplated as may be set forth in some of the appended claims." ] ]
Patent_15876048
[ [ "SYSTEM AND METHOD FOR FINGERPRINTING DATASETS", "Systems and methods for the matching of datasets, such as input audio segments, with known datasets in a database are disclosed.", "In an illustrative embodiment, the use of the presently disclosed systems and methods is described in conjunction with recognizing known network message recordings encountered during an outbound telephone call.", "The methodologies include creation of a ternary fingerprint bitmap to make the comparison process more efficient.", "Also disclosed are automated methodologies for creating the database of known datasets from a larger collection of datasets." ], [ "1.A method for matching an audio stream comprising the steps of: a. generating a collection of ternary acoustic fingerprint bitmaps; b. subdividing each ternary acoustic fingerprint bitmap into a plurality of segments; c. obtaining a hash key from each segment; and d. aggregating obtained hash keys from the ternary acoustic fingerprint bitmaps into a lookup table.", "2.The method of claim 1, wherein said ternary acoustic fingerprint bitmap is generated for an audio object to detect.", "3.The method of claim 1, wherein the generating of step (a) further comprises the step of generating a number of ternary values per frame of audio.", "4.The method of claim 1, wherein the plurality of segments are equal in length.", "5.The method of claim 1, wherein the plurality of segments comprises four equal segments.", "6.The method of claim 1, wherein the hash key of step (c) is obtained by extracting a number of ternary values from ternary values of a number of frames from each segment.", "7.The method of claim 6, wherein the number of frames of each segment evenly divides the number of ternary values.", "8.The method of claim 7, wherein said number of ternary values is 128.9.The method of claim 1 further comprising the steps of: e. generating a number of bit vectors from a number of input audio frames; f. combining the bit vectors into a binary hash key; g. comparing the binary hash key from step (f) against all obtained hash keys in the lookup table.", "h. identifying audio fingerprints corresponding to matching hash keys, wherein, if a match is not found, repeating the method from step (e).", "10.The method of claim 9, wherein the binary hash key comprises a number of bits.", "11.The method of claim 10, wherein the number of input audio frames evenly divides the number of bits.", "12.The method of claim 11, wherein the number of bits is 128.13.The method of claim 9, wherein said comparing of step (g) is performed by computing a masked Hamming distance.", "14.The method of claim 13, wherein said computing is parallelized and optimized with at least one of: Single-Instruction-Multiple Data Instructions and population count instruction.", "15.The method of claim 13, wherein said hash keys in the lookup table match with a low masked Hamming distance.", "16.The method of claim 9, wherein step (h) further comprises the steps of: a. performing a first match with a first criteria; b. identifying fingerprints matching said first criteria as candidate matches; c. performing a second match on said candidate matches with a second criteria; and d. declaring candidate matches meeting the second criteria a match.", "17.The method of claim 16, wherein the first criteria and the second criteria are derived from a bit error rate.", "18.The method of claim 17, wherein at least one of: said first criteria comprises a lower number of standard deviations and said second criteria comprises a higher number of standard deviations.", "19.The method of claim 18, wherein at least one of: said lower number is 3 and said higher number is 9.20.-29.", "(canceled)" ], [ "<SOH> BACKGROUND OF THE DISCLOSED EMBODIMENTS <EOH>The background of the present disclosure and the illustrative embodiments disclosed herein are described in the context of identifying known audio recordings encountered during an outbound telephone call, for example during a call placed from a contact center.", "However, the present invention has applicability to the identification of any segment of audio or an image (as used herein, the term “image” is intended to encompass both still and moving images), regardless of the type or source of the audio or image, and regardless of in what circumstances the audio or image is encountered.", "Furthermore, the present invention also has applicability to the identification of any segment of data such as, for example, data obtained from any type of sensor.", "Therefore, as used herein, the term “dataset” shall encompass a collection of any type of data, whether comprising audio, image, or other type of data.", "In a classic contact center scenario, outbound calls are made either automatically (by a class of devices known as “automated dialers” or “autodialers”) or manually.", "A number of human “agents” are available to join into calls that are determined to reach a live person at the called end.", "In this way, efficiencies are obtained by not having agents involved in a call until it is determined that there is a live person at the called end with whom the agent may speak.", "The use of automated equipment to monitor the telephone line during the outbound call is referred to as call progress analysis (CPA).", "CPA is a class of algorithms that operate on audio and network signaling during call setup.", "The goal of CPA is to determine the nature of the callee, or the outcome of call setup to an external network (traditional public switched telephone network or Voice over Internet Protocol (VoIP)).", "Specifically, when a call or session is being established, the caller or initiator must determine whether it was answered by a live speaker, if the line is busy, etc.", "When the caller is an automated application, such as an automated dialer or message broadcasting system, CPA algorithms are used to perform the classification automatically.", "CPA is used to interpret so-called call-progress tones, such as ring back and busy, that are delivered by the telephone network to the calling entity.", "Traditional CPA is performed using low- and high-pass frequency discriminators together with energy measurements over time to qualify in-band signaling tones.", "Another method for classifying audio on an outbound call is known as Voice Activity Detection (VAD), which is a class of audio processing algorithms that identify where speech is present in an audio stream.", "The detected speech may originate from any source, including a live speaker or a prerecorded message.", "Modern VAD algorithms use spectral analysis to distinguish the utterance of a primary speaker from background noise.", "A subclass of CPA algorithms that extract speaking patterns using VAD, and determine whether the patterns originate from a live speaker or a prerecorded message, is known as Answering Machine Detection (AMD).", "By identifying calls that do not connect to a live speaker, an accurate AMD algorithm can significantly increase throughput of an automated dialer.", "However, false positives from AMD lead to silent or abandoned calls, causing revenue loss for the contact center, and negative impressions amongst the public.", "The quality of an AMD algorithm is a function of the accuracy and response time, and some regions of the world (notably the U.S. and U.K.) impose strict legal requirements on both.", "AMD is not an exact science, and the optimal approach is an open problem.", "To achieve acceptable accuracy, speed, and flexibility, AMD algorithms use a combination of heuristics and statistical models such as neural networks to classify an utterance as live or pre-recorded.", "Although many commercial AMD systems available on the market report high accuracy rates in the marketing literature (e.g., 95% or more), there is no independent auditor for these figures, and the actual accuracy rate is typically much lower in practice (e.g., 80% or less), as reflected by continued widespread complaints.", "A general ban has been proposed by some consumer advocacy groups, and some contact centers simply cannot use AMD because of its limitations.", "A relatively new science of audio identification is known as Acoustic Fingerprinting, in which a system generates a “fingerprint” of a candidate audio stream, and compares it against a database of known fingerprints, analogous to human fingerprinting used in forensics.", "In this context, a “fingerprint” is a condensed digest of an audio stream that can quickly establish perceptual equality with other audio streams.", "A database of known fingerprints may associate known fingerprints with meta-data such as “title”, “artist”, etc.", "The past ten years have seen a rapidly growing scientific and industrial interest in fingerprinting technology for audio and images.", "Applications include identifying songs and advertisements, media library management, and copyright compliance.", "Various acoustic fingerprinting algorithm classes have been proposed, and the most prevalent today are those based on either “landmarks” or “bitmaps”.", "Landmark-based algorithms extract discrete features from an audio stream called “landmarks”, such as spectral peaks, sudden changes in tone, pitch, loudness, etc.", "The optimal choice of landmark is an open question guided mostly by heuristics.", "The acoustic fingerprint is stored as a sequence of data structures that describe each landmark.", "At runtime, landmarks extracted from a candidate audio stream are compared to a database of fingerprints based on a distance metric.", "Bitmap-based algorithms analyze an audio stream as a sequence of frames, and use a filter bank to quantize each frame into a bit vector of size N, where N is typically chosen for convenience as the number of bits in a C-style integer, e.g.", "Nϵ {8, 16, 32, or 64}.", "A popular and well-studied example is known as the “Haitsma-Kalker algorithm”, which computes a binary bitmap using a filter that compares short-term differences in both time and frequency.", "The Haitsma-Kalker Algorithm has been well-studied in the literature.", "It's inventors, Jaap Haitsma and Ton Kalker, have published a report of use of the Haitsma-Kalker Algorithm and the comparison of binary acoustic fingerprint bitmaps to identify three (3) second recordings of songs from a database of millions of songs (Haitsma and Kalker, “A Highly Robust Audio Fingerprinting System,” Journal of New Music Research, Vol.", "32, No.", "2 (2003), pp.", "211-221).", "The complete acoustic fingerprint is stored as a sequence of bit vectors, or a bitmap.", "As illustrated in FIG.", "1A-C , there are shown three images of an audio stream containing a message from a telephone network saying “This number has been disconnected”.", "FIG.", "1A shows the original audio wave signal, with 1.5 seconds of audio sampled at 8000 KHz.", "FIG.", "1B shows a spectrogram of the original audio input signal, with dark regions indicating high energy at a particular frequency.", "FIG.", "1C shows a binary acoustic fingerprint bitmap created using the Haitsma-Kalker algorithm, with height N=16.The height is determined by the number of bits computed at each frame, and the width is determined by the number of frames in the audio stream.", "At runtime, the bitmap computed from a candidate audio stream is compared to a database of bitmaps based on the number of non-matching bits, also known as the Hamming distance.", "The use of bitmap matching and the process of acoustic fingerprinting is a powerful emerging tool in the science of audio recognition; however, it is computationally intense and requires several seconds of sampled audio to make a match in many cases.", "This delay makes it not well suited for use in call progress analysis.", "Accordingly, there remains a need for faster and more accurate systems and methods for identifying audio, both in the general case and during an outbound call attempt." ], [ "<SOH> SUMMARY OF THE DISCLOSED EMBODIMENTS <EOH>Systems and methods for the matching of datasets, such as input audio segments, with known datasets in a database are disclosed.", "In an illustrative embodiment, the use of the presently disclosed systems and methods is described in conjunction with recognizing known network message recordings encountered during an outbound telephone call.", "The methodologies include creation of a ternary fingerprint bitmap to make the comparison process more efficient.", "Also disclosed are automated methodologies for creating the database of known datasets from a larger collection of datasets.", "In one embodiment, a method for matching an audio stream is disclosed, the method comprising the steps of: a) generating a collection of ternary acoustic fingerprint bitmaps; b) subdividing each ternary acoustic fingerprint bitmap into a plurality of segments; c) obtaining a hash key from each segment; and d) aggregating obtained hash keys from the ternary acoustic fingerprint bitmaps into a lookup table.", "In another embodiment, a method for extracting fingerprints for common recordings is disclosed, the method comprising the steps of: a) identifying segments of interest from a dataset of recordings by a means of classification; b) generating fingerprint candidates for said identified segments; c) adding said fingerprint candidates to an acoustic fingerprint database; d) repeating steps (a) and (b) to process the recordings in the dataset using the fingerprint database containing said fingerprint candidates added in step (c); and e) removing fingerprint candidates from the database that were not detected a specified number of times.", "In a further embodiment, a method for extracting fingerprints for common data is disclosed, the method comprising the steps of: a) identifying subsets of interest from a dataset by means of classification; b) generating fingerprint candidates for said subsets; c) adding said fingerprint candidates to a database; d) repeating steps (a) and (b) to process the dataset using the database in step (c) containing the additions of fingerprint candidates; and e) removing fingerprint candidates from the database that do not meet a specified criteria.", "Other embodiments are also disclosed." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS The present application is a continuation of U.S. patent application Ser.", "No.", "13/432,838, filed on Mar.", "28, 2012, now allowed, and titled SYSTEM AND METHOD FOR FINGERPRINTING DATASETS.", "The disclosure of the prior application is considered part of and is incorporated by reference in the disclosure of this application.", "TECHNICAL FIELD OF THE DISCLOSED EMBODIMENTS The present invention generally relates to identifying known datasets, such as audio signals and, more particularly, to systems and methods for fingerprinting datasets.", "BACKGROUND OF THE DISCLOSED EMBODIMENTS The background of the present disclosure and the illustrative embodiments disclosed herein are described in the context of identifying known audio recordings encountered during an outbound telephone call, for example during a call placed from a contact center.", "However, the present invention has applicability to the identification of any segment of audio or an image (as used herein, the term “image” is intended to encompass both still and moving images), regardless of the type or source of the audio or image, and regardless of in what circumstances the audio or image is encountered.", "Furthermore, the present invention also has applicability to the identification of any segment of data such as, for example, data obtained from any type of sensor.", "Therefore, as used herein, the term “dataset” shall encompass a collection of any type of data, whether comprising audio, image, or other type of data.", "In a classic contact center scenario, outbound calls are made either automatically (by a class of devices known as “automated dialers” or “autodialers”) or manually.", "A number of human “agents” are available to join into calls that are determined to reach a live person at the called end.", "In this way, efficiencies are obtained by not having agents involved in a call until it is determined that there is a live person at the called end with whom the agent may speak.", "The use of automated equipment to monitor the telephone line during the outbound call is referred to as call progress analysis (CPA).", "CPA is a class of algorithms that operate on audio and network signaling during call setup.", "The goal of CPA is to determine the nature of the callee, or the outcome of call setup to an external network (traditional public switched telephone network or Voice over Internet Protocol (VoIP)).", "Specifically, when a call or session is being established, the caller or initiator must determine whether it was answered by a live speaker, if the line is busy, etc.", "When the caller is an automated application, such as an automated dialer or message broadcasting system, CPA algorithms are used to perform the classification automatically.", "CPA is used to interpret so-called call-progress tones, such as ring back and busy, that are delivered by the telephone network to the calling entity.", "Traditional CPA is performed using low- and high-pass frequency discriminators together with energy measurements over time to qualify in-band signaling tones.", "Another method for classifying audio on an outbound call is known as Voice Activity Detection (VAD), which is a class of audio processing algorithms that identify where speech is present in an audio stream.", "The detected speech may originate from any source, including a live speaker or a prerecorded message.", "Modern VAD algorithms use spectral analysis to distinguish the utterance of a primary speaker from background noise.", "A subclass of CPA algorithms that extract speaking patterns using VAD, and determine whether the patterns originate from a live speaker or a prerecorded message, is known as Answering Machine Detection (AMD).", "By identifying calls that do not connect to a live speaker, an accurate AMD algorithm can significantly increase throughput of an automated dialer.", "However, false positives from AMD lead to silent or abandoned calls, causing revenue loss for the contact center, and negative impressions amongst the public.", "The quality of an AMD algorithm is a function of the accuracy and response time, and some regions of the world (notably the U.S. and U.K.) impose strict legal requirements on both.", "AMD is not an exact science, and the optimal approach is an open problem.", "To achieve acceptable accuracy, speed, and flexibility, AMD algorithms use a combination of heuristics and statistical models such as neural networks to classify an utterance as live or pre-recorded.", "Although many commercial AMD systems available on the market report high accuracy rates in the marketing literature (e.g., 95% or more), there is no independent auditor for these figures, and the actual accuracy rate is typically much lower in practice (e.g., 80% or less), as reflected by continued widespread complaints.", "A general ban has been proposed by some consumer advocacy groups, and some contact centers simply cannot use AMD because of its limitations.", "A relatively new science of audio identification is known as Acoustic Fingerprinting, in which a system generates a “fingerprint” of a candidate audio stream, and compares it against a database of known fingerprints, analogous to human fingerprinting used in forensics.", "In this context, a “fingerprint” is a condensed digest of an audio stream that can quickly establish perceptual equality with other audio streams.", "A database of known fingerprints may associate known fingerprints with meta-data such as “title”, “artist”, etc.", "The past ten years have seen a rapidly growing scientific and industrial interest in fingerprinting technology for audio and images.", "Applications include identifying songs and advertisements, media library management, and copyright compliance.", "Various acoustic fingerprinting algorithm classes have been proposed, and the most prevalent today are those based on either “landmarks” or “bitmaps”.", "Landmark-based algorithms extract discrete features from an audio stream called “landmarks”, such as spectral peaks, sudden changes in tone, pitch, loudness, etc.", "The optimal choice of landmark is an open question guided mostly by heuristics.", "The acoustic fingerprint is stored as a sequence of data structures that describe each landmark.", "At runtime, landmarks extracted from a candidate audio stream are compared to a database of fingerprints based on a distance metric.", "Bitmap-based algorithms analyze an audio stream as a sequence of frames, and use a filter bank to quantize each frame into a bit vector of size N, where N is typically chosen for convenience as the number of bits in a C-style integer, e.g.", "Nϵ {8, 16, 32, or 64}.", "A popular and well-studied example is known as the “Haitsma-Kalker algorithm”, which computes a binary bitmap using a filter that compares short-term differences in both time and frequency.", "The Haitsma-Kalker Algorithm has been well-studied in the literature.", "It's inventors, Jaap Haitsma and Ton Kalker, have published a report of use of the Haitsma-Kalker Algorithm and the comparison of binary acoustic fingerprint bitmaps to identify three (3) second recordings of songs from a database of millions of songs (Haitsma and Kalker, “A Highly Robust Audio Fingerprinting System,” Journal of New Music Research, Vol.", "32, No.", "2 (2003), pp.", "211-221).", "The complete acoustic fingerprint is stored as a sequence of bit vectors, or a bitmap.", "As illustrated in FIG.", "1A-C, there are shown three images of an audio stream containing a message from a telephone network saying “This number has been disconnected”.", "FIG.", "1A shows the original audio wave signal, with 1.5 seconds of audio sampled at 8000 KHz.", "FIG.", "1B shows a spectrogram of the original audio input signal, with dark regions indicating high energy at a particular frequency.", "FIG.", "1C shows a binary acoustic fingerprint bitmap created using the Haitsma-Kalker algorithm, with height N=16.The height is determined by the number of bits computed at each frame, and the width is determined by the number of frames in the audio stream.", "At runtime, the bitmap computed from a candidate audio stream is compared to a database of bitmaps based on the number of non-matching bits, also known as the Hamming distance.", "The use of bitmap matching and the process of acoustic fingerprinting is a powerful emerging tool in the science of audio recognition; however, it is computationally intense and requires several seconds of sampled audio to make a match in many cases.", "This delay makes it not well suited for use in call progress analysis.", "Accordingly, there remains a need for faster and more accurate systems and methods for identifying audio, both in the general case and during an outbound call attempt.", "SUMMARY OF THE DISCLOSED EMBODIMENTS Systems and methods for the matching of datasets, such as input audio segments, with known datasets in a database are disclosed.", "In an illustrative embodiment, the use of the presently disclosed systems and methods is described in conjunction with recognizing known network message recordings encountered during an outbound telephone call.", "The methodologies include creation of a ternary fingerprint bitmap to make the comparison process more efficient.", "Also disclosed are automated methodologies for creating the database of known datasets from a larger collection of datasets.", "In one embodiment, a method for matching an audio stream is disclosed, the method comprising the steps of: a) generating a collection of ternary acoustic fingerprint bitmaps; b) subdividing each ternary acoustic fingerprint bitmap into a plurality of segments; c) obtaining a hash key from each segment; and d) aggregating obtained hash keys from the ternary acoustic fingerprint bitmaps into a lookup table.", "In another embodiment, a method for extracting fingerprints for common recordings is disclosed, the method comprising the steps of: a) identifying segments of interest from a dataset of recordings by a means of classification; b) generating fingerprint candidates for said identified segments; c) adding said fingerprint candidates to an acoustic fingerprint database; d) repeating steps (a) and (b) to process the recordings in the dataset using the fingerprint database containing said fingerprint candidates added in step (c); and e) removing fingerprint candidates from the database that were not detected a specified number of times.", "In a further embodiment, a method for extracting fingerprints for common data is disclosed, the method comprising the steps of: a) identifying subsets of interest from a dataset by means of classification; b) generating fingerprint candidates for said subsets; c) adding said fingerprint candidates to a database; d) repeating steps (a) and (b) to process the dataset using the database in step (c) containing the additions of fingerprint candidates; and e) removing fingerprint candidates from the database that do not meet a specified criteria.", "Other embodiments are also disclosed.", "BRIEF DESCRIPTION OF THE DRAWINGS FIGS.", "1A-C are an audio wave, spectrogram and binary acoustic fingerprint bitmap, respectively.", "FIG.", "2 is a schematic flow diagram of one embodiment of a method for building an acoustic fingerprint; FIG.", "3A is a graph of amplitude vs. time for a set of exemplary sliding windows used in a transformation according to one embodiment; FIG.", "3B is a spectrogram of an audio sample; FIG.", "4 is a schematic representation of the Mel scale; FIG.", "5 is a graphical representation of the Haitsma-Kalker Algorithm; FIG.", "6 is a schematic flow diagram illustrating a method for creating ternary bitmaps according to one embodiment; FIG.", "7 is a schematic graphical representation of the creation of a ternary bitmap from a binary bitmap according to one embodiment; FIG.", "8 is a schematic flow diagram of the creation of a hash key from a ternary bitmap according to one embodiment; FIG.", "9 is a graphical representation of the process of FIG.", "7; FIG.", "10 is a schematic flow diagram of a matching procedure using hash keys according to one embodiment; and FIG.", "11 is a schematic flow diagram of a method for extracting fingerprints for common recordings from large audio datasets according to one embodiment.", "DETAILED DESCRIPTION OF THE DISCLOSED EMBODIMENTS For the purposes of promoting an understanding of the principles of the invention, reference will now be made to the embodiment illustrated in the drawings, and specific language will be used to describe that embodiment.", "It will nevertheless be understood that no limitation of the scope of the invention is intended.", "Alterations and modifications in the illustrated systems and methods, and further applications of the principles of the invention as illustrated therein, as would normally occur to one skilled in the art to which the invention relates are contemplated, are desired to be protected.", "Such alternative embodiments require certain adaptations to the embodiments discussed herein that would be obvious to those skilled in the art.", "Although the various embodiments disclosed herein will be described in the context of identifying known recordings encountered during an outbound telephone call, for example during a call placed from a contact center, the present invention has applicability to the identification of any segment of audio, image, or other type of data, regardless of the type or source of the audio, image, or other type of data, and regardless of in what circumstances the audio, image, or other type of data is encountered.", "Additionally, the present invention has applicability to the recognition of any type of dataset having two or more dimensions.", "The predominant reliance on the recognition of audio recordings herein is simply for convenience of description.", "The Use of Acoustic Fingerprinting in a Call Progress Analysis System.", "Call Progress Analysis may be improved by using a system that augments conventional AMD with an acoustic fingerprinting system to identify specific call progress events of interest including, but not limited to: a.", "Telephone network messages (e.g., “We're sorry”; “The number or code you have dialed is incorrect”) b. Voicemail greetings shared by multiple subscribers (e.g., “Hello, the party you have dialed”) c. Colored tones, jingles, chimes d. Ringback tones containing music or speech (e.g., “Please hold while your call is completed”) e. Call screeners f. Privacy managers (e.g., “You have reached a number that does not accept solicitations”) g. Interactive Voice Response (IVR) prompts These are collectively referred to herein as “network messages.” All such network messages share the common trait that the same audio is used by the network in certain situations for calls placed to multiple called parties.", "Therefore, a dialing program should expect to encounter these network messages in the future, and identifying them as such will help the call progress analysis software determine that a live speaker has not been reached.", "It is desired that the call progress analysis software exhibit the following characteristics: 1.Efficient (low use of CPU and memory) 2.Fast (low latency and delay) 3.Robust (low rate of false negatives) 4.Accurate (low rate of false positives) 5.Scalable (low lookup cost) 6.Repeatable (low learning curve) In one embodiment, during the real-time progress of an outbound call, the CPA system processes the audio stream using both a conventional AMD algorithm and an acoustic fingerprinting system.", "As the audio proceeds, the acoustic fingerprinting system identifies whether there is a likely match in the database of acoustic fingerprints of known network messages.", "If so, any output from the AMD algorithm is preempted: instead, the CPA system reports specific call progress events based on the matched acoustic fingerprint.", "For the general case where the acoustic fingerprint system finds no matches in the database, the conventional AMD algorithm is used to detect a greeting, and report the event of either a live speaker or an answering machine.", "All events are interpreted by the user of the CPA system to choose an appropriate response, such as whether to proceed or terminate the call, dispatch to an agent, adjust the dialer plan, etc.", "In other embodiments, the acoustic fingerprinting system is used without an additional CPA mechanism.", "FIG.", "2 schematically illustrates one embodiment of a method for building an acoustic fingerprint.", "In order to build an acoustic fingerprint, either of a known audio segment or of a candidate audio segment from a current telephone call, a time varying spectral representation of the signal (referred to herein as a “spectrogram”) is created (as indicated at step 100) using any desired transform, such as Discrete Fourier Transform (DFT), Discrete Cosine Transform (DCT), wavelet transform, or even just a set of filter banks, to name just four non-limiting examples.", "At each frame, the power spectrum in frequency space is computed.", "For example, FIG.", "3A illustrates amplitude vs. time for the sliding windows used in a Fast Fourier Transform (FFT, a particularly efficient algorithm to implement Discrete Fourier Transform) of an audio sample using the following parameters: Sample rate: 8 kHz Frame duration: 30 milliseconds Step size: 20 milliseconds Overlap: ⅓ FFT size: 256 A sample spectrogram of an audio sample using this technique is illustrated in FIG.", "3B.", "The next step is to create a binary acoustic fingerprint bitmap, as indicated at step 102.The power spectrogram may be used as is, or it may be optionally transformed in order to condense the data.", "Any transformation technique that will condense the data may be used.", "To give just one non-limiting example, the Haitsma-Kalker Algorithm may be used, where a sequence of frames are created and are combined to build the acoustic fingerprint bitmap.", "A filter bank can be used to quantize each frame into a bit vector of size N, where N may be chosen for convenience as the number of bits in a C-style integer (8, 16, 32 or 64).", "In one embodiment, a Mel-scale filter bank is used to transform the power spectrum data into Mel space with (N+1) bands, as indicated at step 104.The Mel scale is a perceptual scale of pitches judged by listeners to be equal in distance from one another, as illustrated in FIG.", "4.From the sequence of (N+1)-band spectrums in Mel space, a sequence of N-bit binary fingerprint frame values based on band energy differences over successive frames is computed at step 106.In one embodiment, this is done using the Haitsma-Kalker Algorithm as follows: F  ( n , m ) = { 1 if   E  ( n , m ) - E  ( n , m + 1 ) - ( E  ( n - 1 , m ) - E  ( n - 1 , m + 1 ) ) > 0 0 if   E  ( n , m ) - E  ( n , m + 1 ) - ( E  ( n - 1 , m ) - E  ( n - 1 , m + 1 ) ) ≤ 0 where: E(n,m) is the energy of frequency band m of frame n, and F(n,m) is the mth bit of fingerprint frame n This is illustrated schematically in FIG.", "5.Thus, the acoustic fingerprint is built up as a vector of N-bit integers, one integer per frame.", "FIG.", "1C illustrates an exemplary 16-bit binary acoustic fingerprint bitmap.", "For use during call progress analysis, a database is maintained that contains binary acoustic fingerprint bitmaps for known network messages.", "In one embodiment, during the real-time progress of an outbound call, the CPA system processes the audio stream using both a conventional AMD algorithm and an acoustic fingerprinting system.", "As the audio proceeds, the acoustic fingerprinting system creates binary acoustic fingerprint bitmaps of the incoming audio and compares those bitmaps to known network message bitmaps stored in a database (step 108).", "The CPA system identifies whether there is a match in the database of binary bitmaps (step 110), indicating that the outbound call has resulted in receipt of a known network message instead of a live speaker (step 112).", "If so, any output from the AMD algorithm is preempted: instead, the CPA system reports specific call progress events based on the matched acoustic fingerprint.", "For the general case where the acoustic fingerprint system finds no matches in the database, the conventional AMD algorithm is used to detect a greeting, and report the event of either a live speaker or an answering machine (step 114).", "All events are interpreted by the user of the CPA system to choose an appropriate response, such as whether to proceed or terminate the call, dispatch to an agent, adjust the dialer plan, etc.", "In other embodiments, the binary acoustic fingerprinting bitmap matching system is used without an additional CPA mechanism.", "The Haitsma-Kalker Algorithm has been well-studied in the literature.", "In Haitsma and Kalker's published report of use of the Haitsma-Kalker Algorithm and the comparison of binary acoustic fingerprint bitmaps to identify three (3) second recordings of songs from a database of millions of songs (Haitsma and Kalker, “A Highly Robust Audio Fingerprinting System,” Journal of New Music Research, Vol.", "32, No.", "2 (2003), pp.", "211-221).", "Their system required a large frame size, large overlap/small step size, and large fingerprints in order to achieve good results.", "The parameters they used were: Sample rate: 5 kHz Frame duration: 370 milliseconds Step size: 10 milliseconds Overlap: 31/32 FFT size: 2048 The Haitsma-Kalker algorithm computes a binary acoustic fingerprint bitmap with a relatively low Signal-to-Noise ratio, with bits highly sensitive to noise and windowing artifacts.", "To achieve an acoustic fingerprinting system with acceptably high accuracy and low false positive rate typically requires a relatively long segment of audio (˜3 seconds) with large frame size (370 ms) and large overlap between frames (31/32, or about 97%).", "Such a system is computationally intensive and requires a relatively large audio sample to make reliable comparisons, both of which are undesirable in many audio matching scenarios.", "The present inventors have observed that many bits in a binary acoustic fingerprint bitmap are sensitive to noise and artifacts resulting from the transform into the spectral representation (windowing), especially where the energy of the signal is relatively small.", "A proposed solution is to mask out bits of little value due to their sensitivity to noise and windowing artifacts, and compute the error rate of the bitmap comparisons using only the bits that are in the mask (i.e., the bits that are not masked out).", "Ternary Bitmap Acoustic Fingerprint Using Mask Bits to Obtain High Signal-to-Noise Ratio (SNR) To improve the bitmap matching speed without sacrificing accuracy, one embodiment of the present invention makes the following modification to any acoustic fingerprinting algorithm that generates a binary bitmap.", "In the training stage where the database of known network message bitmaps is created, the methodology of FIG.", "6 may be implemented.", "At step 200, the binary acoustic fingerprint bitmap is created for the audio segment using the same process described hereinabove with respect to FIG.", "2.At step 202, in the illustrated embodiment the first sample is deleted from the audio segment (although other segment modification schemes may be employed, as discussed below), and at step 204 another binary acoustic fingerprint bitmap is created for the modified audio segment using the same process described hereinabove with respect to FIG.", "2.Steps 202-204 are repeated X times (step 206), where X is the number of samples in each frame used by the acoustic fingerprinting process of FIG.", "2.This process will generate X binary acoustic fingerprint bitmaps of the audio segment.", "The X binary acoustic fingerprint bitmaps are combined into a ternary bitmap at step 208 as follows.", "If a bit is 0 in all X binary bitmaps, set the bit in the ternary bitmap to 0 If a bit is 1 in all X binary bitmaps, set the bit in the ternary bitmap to 1 Otherwise, set the bit of the ternary bitmap to * (“Don't Care”) The “Don't Care” bits change in the successive binary acoustic fingerprint bitmaps because they are sensitive to framing, noise, compression, and other effects that introduce signal distortion.", "It will be appreciated from the above description that the “Don't Care” bits may be defined in other ways, such as a predetermined percentage of bit values changing across the bitmaps, etc.", "If the ternary bitmap is used for bitmap comparison (step 210) and the “Don't Care” bits are ignored during the comparison process, the “Don't care” bits mask out these regions in frequency and time of the original binary acoustic fingerprint bitmap that introduce signal distortion.", "FIG.", "7 illustrates an example comparison between a binary bitmap and its associated ternary bitmap.", "It will also be appreciated from the above description that the input signal can be artificially degraded before computing the acoustic fingerprint by adding noise or other artifacts commonly introduced by the communication channel in order to make the acoustic fingerprint and mask more sensitive.", "At runtime, these “Don't Care” bits are excluded from the evaluated “masked Hamming distance” between the candidate audio stream and the database of known fingerprints.", "Use of the ternary bitmap mask eliminates false negatives due to framing misalignment between the input candidate audio stream and the recordings in the database.", "By excluding the bits most sensitive to windowing and noise, the ternary fingerprint system is more robust than its binary counterpart, and achieves comparable accuracy and false positive rate with much fewer bits.", "It will be appreciated that the above steps create many fingerprints of the same signal, with the analysis window shifted by a fraction of the frame size, and those fingerprints are then used to identify which parts of the fingerprint change.", "Therefore, in step 202 the analysis window may be shifted by any fraction of the frame size, rather than the illustrated single-sample shift.", "It will additionally be appreciated that the acoustic fingerprint and ternary bitmap (mask) may be represented in ways other than as vectors of vectors where each element is a bit with a value of zero or one, but instead more generally as vectors of vectors where each element comprises numeric scores and weights (and quantized into multi-bit representations).", "For example, a method for creating a weighted compressed representation of a dataset may comprise the steps of a) computing a compressed representation of the dataset; b) deleting a first number of elements from the dataset to create a modified dataset; c) computing another compressed representation of the modified dataset; d) repeating steps (b) and (c) a plurality of times to create a plurality of compressed representations; and e) combining the plurality of compressed representations into a weighted compressed representation, where each weight in the weighted compressed representation is computed as a function of the elements in the plurality of compressed representations.", "In some embodiments, the compressed representation is a two-dimensional vector of first numbers.", "In some embodiments the first numbers are each represented with a first number of bits, where in the first number of bits may be one bit in some embodiments, and greater than one bit in other embodiments.", "In other embodiments, the weighted compressed representation is a two-dimensional vector of second numbers.", "In some embodiments the second numbers are each represented with a second number of bits.", "In some embodiments, the function computes each said weight as correlation coefficient of the elements in the plurality of compressed representations.", "In some embodiments, the correlation coefficient is computed as follows: 1) if an element is below a first predetermined threshold in a first predetermined number of the plurality of compressed representations, set the correlation coefficient to a first value; 2) if an element is above a second predetermined threshold in a second predetermined number of the plurality of compressed representations, set the correlation coefficient to a second value; 3) otherwise set the correlation coefficient to a third value.", "For example, in one embodiment, the first value is +1, the second value is −1, and the third value is 0 (zero).", "Those skilled in the art will recognize from the present disclosure that the correlation coefficient can be any value between −1 and +1 (or any other desired number range).", "In the present embodiment, the values correspond to the ternary bitmap discussed herein, where a set bit is +1, a cleared bit is −1 and a Don't Care bit is 0.The thresholds can be set to any desired level.", "For example, the first predetermined threshold may be 1 (one) and the second predetermined threshold may be 0 (zero) in one embodiment.", "When computing the correlation coefficient in one embodiment, first predetermined number comprises all of the plurality of compressed representations and the second predetermined number comprises all of the plurality of compressed representations.", "The methodology of FIG.", "6 can be compared to the Haitsma-Kalker algorithm binary acoustic fingerprint bitmap comparison approach of FIG.", "2, which computes a binary acoustic fingerprint bitmap with a relatively low Signal-to-Noise ratio, with bits highly sensitive to noise and windowing artifacts.", "To achieve a fingerprinting system with acceptably high accuracy and low false positive rate using this approach typically requires a relatively long segment of audio (˜3 seconds) with large frame size (370 ms) and large overlap between frames (31/32, or about 97%).", "By comparison, the ternary acoustic fingerprint bitmap methodology disclosed herein, such as that illustrated in FIG.", "6, can obtain comparable matching accuracy and precision much more efficiently, with a short segment of low-bandwidth audio (˜0.25 seconds at 8 kHz), using a small frame size of 30 ms and a small frame overlap of 33%.", "Not only does this achieve matching in approximately 1/12th the amount of time, it is much less computationally intensive and works well with low quality audio samples.", "Real-Time Matching of Acoustic Fingerprints in a Database with Minimal Delay Using Exhaustive Search Most existing acoustic fingerprinting systems are not well adapted for real-time applications because they require a large segment of a source audio stream to achieve a valid match.", "The requirement imposes a time delay of several seconds from the beginning of the matched segment before a matching fingerprint can be confirmed.", "However, to use fingerprinting in real-time in tandem with other signal processing algorithms such as conventional AMD, the fingerprinting system must identify whether a match is likely within a fraction of a second.", "To achieve minimal delay, the present inventors propose an approach using an optimized exhaustive search to match an audio stream in real-time against a database on the order of thousands of fingerprints.", "As shown in FIGS.", "8 and 9, during preprocessing a collection of ternary acoustic fingerprint bitmaps, one for each audio object to detect, with N ternary values per frame, is generated (step 300).", "For each fingerprint, the ternary bitmap is subdivided into a plurality of equal segments (step 302).", "In one embodiment, the ternary bitmap is subdivided into four equal segments as shown in FIG.", "9.From each segment, a hash key is obtained (step 304) by extracting the ternary values from 128/N frames of the subdivided fingerprint, for a total of 128 ternary values in each hash key (i.e., a 128-bit ternary hash key).", "It will be appreciated that the hash key may have fewer or a greater number of values.", "All of the hash keys thus obtained from the ternary acoustic fingerprint bitmaps are then aggregated into a single lookup table (step 306).", "The selection of hash keys from various segments of the acoustic fingerprint allows a match to be made even if the candidate audio stream is an interrupted recording and the beginning of the recording is not received.", "For example, if using this methodology for identifying samples of music, the person wishing to identify a song may not have (and most likely did not) start recording a sample of the song to be identified until sometime after the song started playing.", "Use of hash keys from different segments of the acoustic fingerprint allows the system to still make a match between the candidate audio stream and the acoustic fingerprints in the database.", "FIG.", "10 illustrates one embodiment of a matching procedure that may be used at runtime after the lookup table of hash keys has been assembled.", "For each new frame of the input audio stream, a binary bitmap acoustic fingerprinting algorithm is used to generate a new bit vector of length N (step 400).", "The bit vectors from the previous 128/N frames of the input audio stream are combined into a 128-bit binary hash key for lookup (step 402).", "The current 128-bit binary hash key of the input audio stream is compared against all of the ternary hash keys in the lookup table by computing the masked Hamming distance (step 404).", "On modern microprocessors, this calculation can easily be parallelized and optimized with Single-Instruction-Multiple-Data instructions (such as the SSE or AVX SIMD instruction set extensions to the Intel x86 microprocessor architecture) and/or the “population count” instruction.", "If any hash keys in the lookup table match (step 406) with a sufficiently low masked Hamming distance, the audio fingerprint corresponding to the hash key is identified as a “candidate” (step 408).", "The threshold bit error rate (BER) for establishing a candidate may be based on a relatively low value of σcandidate (e.g., 3 standard deviations, although other thresholds may be used).", "If the overall BER for a candidate exceeds a relatively large value of σnotify, (e.g., 9 standard deviations, although other thresholds may be used) (step 410) this candidate is determined to be a match (step 412).", "If no match has been determined, the process returns to step 400 where the next frame is used to generate a new bit vector of length N. By continuing to analyze subsequent frames, the process is able to resolve all candidates as a match or non-match, based upon where the masked Hamming distance falls with respect to the thresholds.", "Method for Extracting Fingerprints for Common Recordings from Large Audio Collections As will be appreciated from the above description, systems and methods are provided for matching an audio sample to a database of known audio recordings.", "The systems and methods described above are computationally efficient and are able to identify a match with an acoustic fingerprint in a database, but a problem remains in how to efficiently identify the audio recordings that will be represented by acoustic fingerprints in the database.", "The methodology described herein below for doing so is discussed in the context of a telephonic contact center; however, those skilled in the art will recognize from the present disclosure that the methodology may be applied to compiling fingerprint databases relating to any type of source audio, images, or other types of data.", "A sizable campaign from a contact center may generate thousands of digital recordings of outbound calls each day.", "From this recording collection, the objective is to extract all audio segments containing call progress events of interest, in order to assist CPA in future call campaigns.", "For example, many calls in a campaign are dialed to numbers on the same network or sub-network, which plays an identical recorded greeting for each subscriber.", "In the absence of an automated data driven technique, the large volumes of data must be listened to by a human subject, to identify candidate segments from which acoustic fingerprints may be extracted.", "The present inventors propose an offline process to automatically identify common acoustic recordings in a large collection of recordings, so they may be detected in future call campaigns to improve the accuracy of CPA.", "The process used for automated identification of fingerprints in our invention is illustrated schematically in FIG.", "11.At step 500, the CPA system, combined with AMD and acoustic fingerprinting (if the database already contains acoustic fingerprints for some known recordings), is used to classify all audio recordings in the collection based on events detected therein.", "For all audio recordings classified as a live speaker or answering machine using conventional AMD, the endpoints of the audio segments that do not comprise silence, background noise, or simple tones are identified at step 502.For example, audio segments containing speaking patterns, music, non-speech signals, etc.", "are identified at step 502.At step 504, a ternary acoustic fingerprint bitmap is generated for all identified segments using the methodology described hereinabove (it will be appreciated that a binary acoustic fingerprint bitmap can be used instead of the ternary bitmap).", "These new acoustic fingerprints are added to the acoustic fingerprint database at step 506.All of the audio recordings in the collection are then re-processed through the CPA/AMD system using the newly-augmented ternary acoustic fingerprint database at step 508.At step 510, the system identifies the augmented fingerprints that are not unique and were detected multiple times (i.e., a recording in the collection being processed matched multiple ones of the augmented acoustic fingerprints, indicating that these are acoustic fingerprints of recordings that were encountered multiple times in the collection).", "Any acoustic fingerprints discovered multiple times are likely candidates for a call progress event of interest, and are therefore left in the acoustic fingerprint database at step 512 for use in future CPA tasks.", "All of the other augmented fingerprints (i.e., those new acoustic fingerprints that were not detected multiple times) are removed from the database at step 514, since they represent unique audio segments of vocal utterances, and therefore cannot be determined to be recorded network messages.", "In this way, an automated system may be used to look through a large collection of recordings (or images or other data) and extract therefrom fingerprints of recordings that were encountered multiple times.", "This methodology allows the acoustic fingerprint database to be built automatically and continuously updated to account for new network messages that may be brought on line by the various telephone companies.", "As can be seen from the above description, the various embodiments allow for the matching of input audio segments with known audio segments in a database.", "The audio segments may originate from any source and contain any type of audio, such as speech, tones, music, or any other audio that is desired to be recognized.", "In an illustrative embodiment, the use of the presently disclosed systems and methods was described in conjunction with recognizing known network message recordings encountered during an outbound telephone call.", "However, those skilled in the art will recognize that the disclosed systems and methods will find application in recognition of any type of two- or more-dimensional dataset, such as any form of audio, image, or other type of data.", "While the organization of steps, software blocks, data and data structures have been illustrated as clearly delineated, a person skilled in the art will appreciate that the delineation between steps, blocks and data is somewhat arbitrary.", "Numerous other arrangements of steps, software blocks and data are possible.", "Finally, it will be understood that the invention is not limited to the embodiments described herein which are merely illustrative of several embodiments for carrying out the invention, and which are susceptible to modification of form, arrangement of parts, steps, details and order of operation.", "The invention, rather, is intended to encompass all such modifications within its spirit and scope, as defined by the claims." ] ]
Patent_15876050
[ [ "TRUST METRICS ON SHARED COMPUTERS", "Particular embodiments of a verification authority associated with a web service may receive a request to access the web service.", "The request may comprise data uniquely identifying a client device.", "The request may have been received from a shared device, wherein the shared device is configured for use by a plurality of users.", "The verification authority may access a social graph of a user associated with the client device to determine whether one or more social-networking users have previously accessed the shared device.", "The verification authority may then transmit to the client device information indicating which of the social-networking users have previously accessed the shared device." ], [ "1.A method comprising: by a verification authority associated with a web service, receiving a request to access the web service, wherein the request comprises data uniquely identifying a client device, wherein the request was received from a shared device, and wherein the shared device is configured for use by a plurality of users; by the verification authority, accessing a social graph of a user associated with the client device to determine whether one or more social-networking users have previously accessed the shared device; and by the verification authority, transmitting to the client device information indicating which of the social-networking users have previously accessed the shared device.", "2.The method of claim 1, further comprising: determining whether an account on a social-networking system for each of the social-networking users had been compromised subsequent to accessing the shared device; and displaying on the display a trust-based metric indicating a number of the social-networking users whose account was compromised subsequent to accessing the shared device.", "3.The method of claim 2, wherein the trust-based metric comprises data from an extended social graph of the user associated with the client device, wherein the extended social graph comprises users not directly connected to the user associated with the client device.", "4.The method of claim 2, further comprising: determining whether the account had been compromised based on whether a password of the account has been reset within a pre-determined period of time subsequent to accessing shared device.", "5.The method of claim 1, wherein the information indicating the social-networking users that accessed the shared device comprises an image of each of the social-networking users that previously accessed the shared device.", "6.The method of claim 1, wherein the shared device is registered with the verification authority.", "7.The method of claim 1, wherein the data uniquely identifying the client device comprises a digital credential transmitted by the client device, the digital credential uniquely identifying the client device.", "8.The method of claim 1, wherein the request to access the web service comprises a request to access the web service by transmitting data through the shared device.", "9.The method of claim 1, further comprising establishing the verification authority associated with the web service.", "10.One or more computer-readable non-transitory storage media embodying software that is operable when executed by one or more processors to: establish a verification authority associated with a web service; by the verification authority, receive a request to access the web service, wherein the request comprises data uniquely identifying a client device, wherein the request was received from a shared device, and wherein the shared device is configured for use by a plurality of users; by the verification authority, access a social graph of a user associated with the client device to determine whether one or more social-networking users have previously accessed the shared device; and by the verification authority, transmit to the client device information indicating which of the social-networking users have previously accessed the shared device.", "11.The media of claim 10, further comprising software that is operable when executed by the one or more processors to: determine whether an account on a social-networking system for each of the social-networking users had been compromised subsequent to accessing the shared device; and display on the display a trust-based metric indicating a number of the social-networking users whose account was compromised subsequent to accessing the shared device.", "12.The media of claim 11, wherein the trust-based metric comprises data from an extended social graph of the user associated with the client device, wherein the extended social graph comprises users not directly connected to the user associated with the client device.", "13.The media of claim 11, further comprising software that is operable when executed by the one or more processors to: determine whether the account had been compromised based on whether a password of the account has been reset within a pre-determined period of time subsequent to accessing shared device.", "14.The media of claim 10, wherein the information indicating the social-networking users that accessed the shared device comprises an image of each of the social-networking users that previously accessed the shared device.", "15.The media of claim 10, wherein the shared device is registered with the verification authority.", "16.The media of claim 10, wherein the data uniquely identifying the client device comprises a digital credential transmitted by the client device, the digital credential uniquely identifying the client device.", "17.The media of claim 10, wherein the request to access the web service comprises a request to access the web service by transmitting data through the shared device.", "18.A system of a verification authority, comprising: one or more processors; and a memory coupled to the processors comprising instructions executable by the processors, the processors being operable when executing the instructions to: receive a request to access the web service, wherein the request comprises data uniquely identifying a client device, wherein the request was received from a shared device, and wherein the shared device is configured for use by a plurality of users; access a social graph of a user associated with the client device to determine whether one or more social-networking users have previously accessed the shared device; and transmit to the client device information indicating which of the social-networking users have previously accessed the shared device.", "19.The system of claim 18, the processors being further operable when executing the instructions to: determine whether an account on a social-networking system for each of the social-networking users had been compromised subsequent to accessing the shared device; and display on the display a trust-based metric indicating a number of the social-networking users whose account was compromised subsequent to accessing the shared device.", "20.The system of claim 19, wherein the trust-based metric comprises data from an extended social graph of the user associated with the client device, wherein the extended social graph comprises users not directly connected to the user associated with the client device." ], [ "<SOH> BACKGROUND <EOH>A mobile electronic device, such as a smartphone, tablet device, laptop computer, etc., has general computing capabilities.", "The mobile electronic device may execute one or more applications such as for example, communications through short-message service (SMS), communications through multimedia-messaging service (MMS), accessing e-mail, accessing Internet content, communications through a short-range wireless (e.g.", "infrared or BLUETOOTH), business applications, gaming, or photography using a camera integrated into the mobile electronic device.", "A smartphone is a particular class of mobile electronic device with telephony capabilities provided through a radio-frequency (RF) communication link whilst moving within a geographic area.", "The smartphone may have a touch sensor integrated with a display screen, where the touch sensor detects touch inputs and the display screen displays content.", "The smartphone connects to a cellular network for access to the public telephone network and Internet content." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>FIG.", "1 illustrates example interactions for an example mobile-device-based trust computing system.", "FIG.", "2 illustrates an example method for mobile-device-based trust computing.", "FIG.", "3 illustrates an example method for determining a trust metric for a shared devices by a verification authority.", "FIG.", "4 illustrates an example method for presenting a trust metric for a shared device on a mobile device.", "FIG.", "5 illustrates an example social-networking system.", "FIG.", "6 illustrates an example mobile device.", "FIG.", "7 illustrates example internal components of an example mobile device.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "PRIORITY This application is a continuation under 35 U.S.C.", "§ 120 of U.S. patent application Ser.", "No.", "14/754,590, filed 29 Jun.", "2015, which is a continuation under 35 U.S.C.", "§ 120 of U.S. patent application Ser.", "No.", "14/498,677, filed 26 Sep. 2014, which is a continuation under 35 U.S.C.", "§ 120 of U.S. patent application Ser.", "No.", "13/541,244, filed 3 Jul.", "2012, all of which are incorporated by reference.", "TECHNICAL FIELD This disclosure generally relates to shared computing resources.", "BACKGROUND A mobile electronic device, such as a smartphone, tablet device, laptop computer, etc., has general computing capabilities.", "The mobile electronic device may execute one or more applications such as for example, communications through short-message service (SMS), communications through multimedia-messaging service (MMS), accessing e-mail, accessing Internet content, communications through a short-range wireless (e.g.", "infrared or BLUETOOTH), business applications, gaming, or photography using a camera integrated into the mobile electronic device.", "A smartphone is a particular class of mobile electronic device with telephony capabilities provided through a radio-frequency (RF) communication link whilst moving within a geographic area.", "The smartphone may have a touch sensor integrated with a display screen, where the touch sensor detects touch inputs and the display screen displays content.", "The smartphone connects to a cellular network for access to the public telephone network and Internet content.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates example interactions for an example mobile-device-based trust computing system.", "FIG.", "2 illustrates an example method for mobile-device-based trust computing.", "FIG.", "3 illustrates an example method for determining a trust metric for a shared devices by a verification authority.", "FIG.", "4 illustrates an example method for presenting a trust metric for a shared device on a mobile device.", "FIG.", "5 illustrates an example social-networking system.", "FIG.", "6 illustrates an example mobile device.", "FIG.", "7 illustrates example internal components of an example mobile device.", "DESCRIPTION OF EXAMPLE EMBODIMENTS FIG.", "1 illustrates example interactions for an example mobile-device-based trust computing system.", "In the example of FIG.", "1, the example mobile-device-based trust computing system includes mobile device 10, shared device 4, and verification authority 31.In particular embodiments, mobile device 10 is associated with a particular user.", "In particular embodiments, verification authority 31 may perform an authentication procedure allowing a user to access shared device 4 or the system that includes verification authority 31 through shared device 4.As an example and not by way of limitation, verification authority 31 is a social-networking system and access to shared device 4 is controlled by a webpage hosted by the social-networking system.", "In particular embodiments, the user may perform an authentication procedure to access a service hosted by verification authority 31 through shared device 4 using mobile device 10.Herein, reference to a verification authority may encompass both the authentication component and the Internet entity providing a service to the user such as for example a social-networking system, a financial institution, or a web portal, where appropriate.", "Alternatively, where appropriate, reference to a verification authority may encompass authentication component, but not the Internet entity hosting the authentication component.", "As part of the trust-based authentication procedure, the user may receive authentication data associated with shared device 4, as illustrated by interaction 60 in FIG.", "1.In particular embodiments, an application (“app”) on mobile device 10 obtains the authentication data from shared device 4.As an example and not by way of limitation, the application on mobile device 10 may capture an image of a quick-response (QR) code presented on a display of shared device 4 and transmit authentication data encoded in the QR code to verification authority 31.As another example, the application executed on mobile device 10 may receive the authentication data from shared device 4 through a wireless protocol, such as for example, BLUETOOTH or WI-FI.", "As another example, the display of shared device 4 may present the authentication data, e.g.", "an alphanumeric verification code, that is manually input into mobile device 10 for transmission to verification authority 31.In particular embodiments, the authentication data from shared device 4 originates from verification authority 31 and is provided to the application on mobile device 10 through shared device 4.In particular embodiments, verification authority 31 may authenticate mobile device 10, shared device 4, or any combination of shared device 4 and mobile devices 10 through the access data transmitted by the application on mobile device 10, as illustrated by interaction 62 in FIG.", "1.In particular embodiments, the access data transmitted to verification authority 31 includes a digital credential associated with mobile device 10 and the authentication data associated with shared device 4 that function as a signed digital certificate.", "As an example and not by way of limitation, the digital credential may include an authentication cookie installed on mobile device 10 when initially accessing verification authority 31 through mobile device 10.The authentication cookie uniquely identifies mobile device 10 or the user to verification authority 31.In particular embodiments, verification authority 31 authenticates the access data, that includes authentication data associated with shared device 4 and the digital credential associated with mobile device 10, transmitted by the application on mobile device 10.Verification authority 31 may compare the access data with verification data associated with shared device 4 and mobile device 10 stored on verification authority 31.As an example and not by way of limitation, the authentication manager of a social-networking system may act as the verification authority 31 and may compare the authentication data associated with shared device 4 and transmitted by mobile device 10 with the verification data stored on the social-networking system.", "As another example, the social-networking system may compare information in the authentication cookie transmitted by mobile device 10 with the verification data stored on the social-networking system.", "Verification authority 31 may transmit a signed digital certificate to shared device 4 in response to authenticating the access data, as illustrated by interaction 64 of FIG.", "1.The user of mobile device 10 is allowed to access shared device 4 in response to shared device 4 receiving the signed digital certificate from verification authority 31.Access to shared device 4 is achieved without providing information of the user to shared device 4.In particular embodiments, shared device 4 is a computer located at a publically accessible location such as for example, an Internet café or a public library.", "In other particular embodiments, shared device 4 is a wireless router of a publically accessible WI-FI hotspot.", "In particular embodiments, shared device 4 in turn may sign the digital certificate signed by verification authority 31 and transmit the digital certificate signed by both shared device 4 and verification authority 31 to the application of mobile device 10 for an additional level of assurance, as illustrated by interaction 66 of FIG.", "1.In particular embodiments, based on authentication of the user on shared device 4 through mobile device 10, verification authority 31 may restore the last saved state associated with the user on a service hosted by verification authority 31 on shared device 4.As an example and not by way of limitation, verification authority 31 may restore a last saved state of a web browser executed on shared device 4.In particular embodiments, verification authority 31 may establish a trust metric for mobile device 10 or shared device 4.System-state or configuration information of mobile device 10 may be transmitted to verification authority 31.As an example and not by way of limitation, mobile device 10 may include a trusted-platform module (TPM) that provides system-state information detailing the configuration of mobile device 10 and including data that indicates which applications are installed on mobile device 10.Moreover, verification authority 31 may access an application store, such as for example GOOGLE PLAY or APP STORE, to obtain a unique signature for each application installed on mobile device 10 according to the system-state data.", "In particular embodiments, the system-state information of mobile device 10 may be used to provide a trust metric for mobile device 10.As an example and not by way of limitation, the authentication manager of social-networking system 30 may compare the information provided by the TPM of mobile device 10 with the unique signatures of the applications installed on mobile device 10.In particular embodiments, a discrepancy between the system-state information and the signatures of the applications installed on mobile device 10 may indicate mobile device 10 has been compromised.", "A compromised mobile device 10 may be denied access to a service hosted by verification authority 31 or to shared device 4.In particular embodiments, shared device 4 is registered with verification authority 31.In particular embodiments, verification authority 31 may scan shared device 4 to detect the presence of viruses or malware on shared device 4.Moreover, verification authority 31 may determine the configuration of shared device 4 including such as for example, the installed software and the versions of the software, operating system, or security patches, that are installed on shared device 4.In particular embodiments, verification authority 31 may collect statistics on the effectiveness of different anti-virus software by tracking the anti-virus software installed on shared device 4 and other devices registered with verification authority 31 and the number of viruses or malware found on those devices.", "Verification authority 31 may provide a trust-based metric on mobile device 10 of the user indicating the “trustworthiness” of shared device 4.In particular embodiments, prior to accessing shared device 4, a social-networking system acting as a verification authority 31 may access the social graph and action store to determine if other users in the social graph of the user of mobile device 10 have previously accessed shared device 4.As described below, the social graph stores connections each user has with other users of a social-networking system and the action store stores actions that have been performed by the users of the social-networking system.", "In particular embodiments, verification authority 31 may transmit one or more names and/or images of other users of the social graph (e.g.", "as a “facepile”) who have previously accessed shared device 10.In particular embodiments, verification authority 31 may present a trust-based metric for shared device 4 based on the number of other users in the social graph of the user who have previously accessed shared device 4 and subsequently had their account on a service hosted by verification authority 31 compromised.", "As described below, the social graph of the user may include information of connections the user has with other users of an online service.", "In particular embodiments, the social graph may also include information of second-order connections, thereby forming a non-extended or extended social graph based at least in part on whether the other users or nodes have direct or indirect connection respectively with the user.", "In particular embodiments, the trust-based metric may include data from the extended social graph of the user to include users who are not directly connected to the user of mobile device 10.As an example and not by way of limitation, data from the extended social graph in cases where the amount of data available from the non-extended social graph is too small to generate a meaningful trust-based metric.", "As an example and not by way of limitation, verification authority 31 may determine an account is compromised based on whether the user reset their account password subsequent to accessing shared device 10 within a pre-determined period of time.", "In particular embodiments, the names and/or images of users in the social graph and the trust-based metric may be displayed on the display of mobile device 10 and the user may decide whether to proceed with accessing shared device 4.Although this disclosure describes a particular trust-based metric that includes particular elements, this disclosure contemplates a trust-based metric that includes any suitable elements, such as for example numerical or graphical data, or a natural language message.", "As an example and not by way of limitation, verification authority 31 may present a message stating “13 of your friends have used this machine without issue.” As another example, verification authority 31 may provide a pie chart indicating a number of users in the social graph that had an issue with their account subsequent to accessing shared device 4 out of the total number of users in the social graph that accessed shared device 4.FIG.", "2 illustrates an example method for mobile-device-based trust computing.", "The method may start at step 100, where a verification authority receives access data from an application on a mobile device of a user.", "The access data may include authentication data associated with a shared device and a digital credential associated with the mobile device.", "At step 102, the verification authority authenticates the access data based on a comparison of the access data with verification data stored by the verification authority.", "In particular embodiments, the digital credential associated with the mobile device may be an authentication cookie installed on the mobile device.", "In other particular embodiments, the authentication data associated with the shared device is encoded in a QR code generated by the verification authority and displayed on a display of the shared device.", "At step 104, the verification authority signs and transmits the signed digital certificate to the shared device in response to the authentication, at which point the method may end.", "The signed digital certificate provides the user access to the shared device.", "Although this disclosure describes and illustrates particular steps of the method of FIG.", "2 as occurring in a particular order, this disclosure contemplates any suitable steps of the method of FIG.", "2 occurring in any suitable order.", "Moreover, although this disclosure describes and illustrates particular components carrying out particular steps of the method of FIG.", "2, this disclosure contemplates any suitable combination of any suitable components carrying out any suitable steps of the method of FIG.", "2.FIG.", "3 illustrates an example method for determining a trust metric for a shared device by a verification authority.", "The method may start at step 150, where a verification authority receives data uniquely identifying a particular user to the verification authority and a request to access a shared device.", "As described above, the shared device is configured for use by multiple users.", "At step 152, the verification authority accesses a social graph of the particular user to determine whether one or more users in the social graph have previously accessed the shared device.", "At step 154, the verification authority transmits information indicating which of the users in the social graph have previously accessed the shared device on a display of the mobile device, at which point the method may end.", "In particular embodiments, the information transmitted by the verification authority may be one or more names and/or images of other users of the social graph who have previously accessed shared device.", "Although this disclosure describes and illustrates particular steps of the method of FIG.", "3 as occurring in a particular order, this disclosure contemplates any suitable steps of the method of FIG.", "3 occurring in any suitable order.", "Moreover, although this disclosure describes and illustrates particular components carrying out particular steps of the method of FIG.", "3, this disclosure contemplates any suitable combination of any suitable components carrying out any suitable steps of the method of FIG.", "3.FIG.", "4 illustrates an example method for presenting on a mobile device trust-based information for a particular shared device.", "The method may start at step 200, where an application on a mobile device of a particular user transmits data uniquely identifying the particular user to a verification authority and a request to access a shared device.", "In particular embodiments, the shared device is located at an Internet café or a public library.", "At step 202, the application on the mobile device presents on a display information from the verification authority indicating which users in a social graph of the particular user have previously accessed the shared device, at which point the method may end.", "As described above, the verification authority may access the social graph of the particular user to determine whether the users in the social graph have previously accessed the shared device.", "In particular embodiments, the trust-based metric may indicate a number of the users in the social graph that had an account compromised subsequent to accessing the shared device.", "Although this disclosure describes and illustrates particular steps of the method of FIG.", "4 as occurring in a particular order, this disclosure contemplates any suitable steps of the method of FIG.", "4 occurring in any suitable order.", "Moreover, although this disclosure describes and illustrates particular components carrying out particular steps of the method of FIG.", "4, this disclosure contemplates any suitable combination of any suitable components carrying out any suitable steps of the method of FIG.", "4.FIG.", "5 illustrates an example social-networking system.", "In particular embodiments, authentication manager 42 in conjunction with one or more external applications 46A-B or platform applications 50A-B of social-networking system 30 may act as the verification authority 31 described above.", "In other particular embodiments, the verification authority may access data stored in social graph 36 and action store 38.In the example of FIG.", "5, a social-networking system 30 and an external server 32 are coupled through a network 34.Network 34 generally represents a network or collection of networks (such as for example the Internet, a corporate intranet, a virtual private network (VPN), a local-area network (LAN), a wireless local-area network (WLAN), a cellular network, a wide-area network (WAN), a metropolitan-area network (MAN), or a combination of two or more such networks) over which social-networking system 30 or external server 32 may communicate with shared device 4 and mobile device 10.A user may interact with social-networking system 30 using shared device 4 in conjunction with mobile device 10.Shared device 4 and mobile device 10 may communicate with social-networking system 30 via an application such as a web browser or native application executed on processor of shared device 4 and mobile device 10.As an example and not by way of limitation, interactions between shared device 10 and social-networking system 30 may include viewing profiles of other users of social-networking system 30, contributing and interacting with media items, joining groups, listing and confirming attendance at events, checking in at locations, liking certain pages, creating pages, and performing other tasks that facilitate social interaction.", "In particular embodiments, shared device 4 may be a publically accessible computing resource, such as for example a shared computer at an Internet café or public library, and mobile device 10 may be a smartphone, as described above.", "In other particular embodiments, shared device 4 may be a virtualized computing resource or a WI-FI or other wireless access point in addition to or instead of a shared computer.", "Although this disclosure describes and illustrates particular interactions between particular devices and the example social-networking system, this disclosure contemplates any suitable interactions between any suitable devices and any suitable system.", "Social-networking system 30 includes components used to store information about users and objects represented in the social networking environment and relationships among the users and objects.", "The social-networking system 30 may include components enabling interactions with shared device 4 or mobile device 10, as described below.", "Components of social-networking system 30 may be hosted on one or more servers.", "This disclosure contemplates any suitable servers, such as servers that are internal to social-networking system 30 or external servers 32.As an example and not by way of limitation, one or more servers may each include one or more advertising servers, applications servers, catalog servers, communications servers, database servers, exchange servers, fax servers, file servers, game servers, home servers, mail servers, message servers, news servers, name or domain-name servers (DNS), print servers, proxy servers, sound servers, standalone servers, web servers, or web-feed servers.", "In particular embodiments, a server includes hardware, software, or both for providing the functionality of the server.", "As an example and not by way of limitation, a server that operates as a web server may be capable of hosting websites containing web pages or elements of web pages and include appropriate hardware, software, or both for doing so.", "In particular embodiments, a web server may host Hyper Text Markup Language (HTML) or other suitable files or dynamically create or constitute files for web pages on request.", "In response to a Hyper Text Transfer Protocol (HTTP) or other request from shared device 4 or mobile device 10, the web server may communicate one or more such files to mobile device 10.As another example, a server that operates as a database server may be capable of providing an interface for interacting with one or more data stores (such as, for example, action store 38 described below).", "Where appropriate, a server may include one or more servers; be unitary or distributed; span multiple locations; span multiple machines; span multiple datacenters; or reside in a cloud, which may include one or more cloud components in one or more networks.", "A social graph 36 of social-networking system 30 stores the connections each user has with other users of social-networking system 30.In particular embodiments, social graph 36 may also store second-order connections.", "The connections may thus be direct or indirect.", "As an example and not by way of limitation, if user A is a first-order connection of user B but not of user C, and B is a first-order connection of C, then C is a second-order connection of A on social graph 36.An action store 38 stores actions that have been performed by the users of social-networking system 30, along with an indication of the time associated with those actions and references to any objects related to the actions.", "Action store 38 may store statistics for specified categories of actions.", "As an example and not by way of limitation, for a given user, action store 38 may contain a number of stories posted in 30 days by a user, a number of photos posted by the user in 30 days, or a number of distinct users that received comments of the user within the past 30 days.", "For a given connection between two users, user A and user B, action store 38 may contain actions such as the number of profile page views from user A to user B, the number of photo page views from user A to user B, and the number of times user A and user B were tagged in the same photo, and these actions may be associated with a timestamp or may be filtered by a cutoff (e.g., 24 hours, 90 days, etc.).", "The actions recorded in action store 38 may be farmed actions, which are performed by a user in response to the social-networking system 30 providing suggested choices of actions to the user.", "A predictor module 40 is responsible for computing a set predictor functions that predict whether a user will perform a set of corresponding actions.", "Each predictor function may be representative of a user's interest in a particular action associated with the predictor function.", "The historical activity of a user may be used as a signal of a user's future interest in the same activity.", "In particular embodiments, the predictor function is generated using a machine-learned algorithm, that is trained using a user's historical activity associated with an action.", "Predictor module 40 thus provides a predictor function for each of a set of actions, where a predictor function may take as an input the a user's historical activity and then outputs a measure of the likelihood that the user will engage in the corresponding activity.", "An authentication manager 42 may allow users to log into social-networking system 30 from mobile device 10 or shared device 4 through an application supporting social-networking system 30.An application programming interface (API) 44 works in conjunction with authentication manager 40 to validate users via external applications 46A-B stored on external server 32.In particular embodiments, authentication manager 42 in conjunction with API 44 may periodically verify account information of the user.", "An affinity module 48 provides a measure of affinity based on input data about the user from the social-networking system 30 using the predictor functions.", "Various processes may request a measure of affinity from affinity module 48.As an example and not by way of limitation, the processes may include basic social-networking system functionality, such as for example newsfeed algorithms, advertising-targeting algorithms, or friend-suggestion algorithms.", "Other processes that request measures of affinity may be executed by one or more platform applications 50A-B, which are applications that operate within the social-networking system 30 but may be provided by third parties other than an operator of the social-networking system 30.Platform applications 50A-B may include social games, messaging services, or any suitable application that uses the social platform provided by social-networking system 30.In particular embodiments, the processes requesting a measure of affinity for a user may include one or more external applications 46A-B executed on external server 32.External applications 46A-B may interact with the social-networking system 30 via API 44.External applications 46A-B can perform various operations supported by the API 44, such as enabling users to send each other messages or SMS messages through social-networking system 30 or showing advertisements routed through social-networking system 30.Herein, reference to SMS messages encompasses messages in text and other forms of content, such as for example, images or links to web content.", "Although this disclosure describes and illustrates a particular social-networking system having a particular configuration of particular components, this disclosure contemplates a social-networking system having any suitable configuration of any suitable components.", "FIG.", "6 illustrates an example mobile device.", "This disclosure contemplates mobile device 10 taking any suitable physical form.", "As example and not by way of limitation, mobile device 10 may be a single-board computer system (SBC) (such as, for example, a computer-on-module (COM) or system-on-module (SOM)), a laptop or notebook computer system, a mobile telephone, a smartphone, a personal digital assistant (PDA), a tablet computer system, or a combination of two or more of these.", "In particular embodiments, mobile device 10 may have a touch screen 12 as an input component.", "In the example of FIG.", "5, touch screen 12 is incorporated on a front surface of mobile device 10.In the case of capacitive touch sensors, there may be two types of electrodes: transmitting and receiving.", "These electrodes may be connected to a controller designed to drive the transmitting electrodes with electrical pulses and measure the changes in capacitance from the receiving electrodes caused by a touch or proximity input.", "In the example of FIG.", "6, one or more antennae 14A-B may be incorporated into one or more sides of mobile device 10.Antennae 14A-B are components that convert electric current into radio waves, and vice versa.", "During transmission of signals, a transmitter applies an oscillating radio frequency (RF) electric current to terminals of antenna 14A-B, and antenna 14A-B radiates the energy of the applied the current as electromagnetic (EM) waves.", "During reception of signals, antennae 14A-B convert the power of an incoming EM wave into a voltage at the terminals of antennae 14A-B.", "The voltage may be transmitted to a receiver for amplification.", "FIG.", "7 illustrates example internal components of an example mobile device.", "Where appropriate, one or more mobile devices 10 may perform without substantial spatial or temporal limitation one or more steps of one or more methods described or illustrated herein.", "As an example and not by way of limitation, one or more mobile devices 10 may perform in real time or in batch mode one or more steps of one or more methods described or illustrated herein.", "In particular embodiments, one or more mobile devices 10 performs one or more steps of one or more methods described or illustrated herein.", "In particular embodiments, one or more mobile devices 10 provides functionality described or illustrated herein.", "In particular embodiments, software running on one or more mobile devices 10 performs one or more steps of one or more methods described or illustrated herein or provides functionality described or illustrated herein.", "Particular embodiments include one or more portions of one or more mobile devices 10.In particular embodiments, mobile device 10 includes a processor 16, memory 18, storage 22, an input/output (I/O) interface 24, a communication component 20, and a bus 26.Although this disclosure describes and illustrates a particular mobile device having a particular number of particular components in a particular arrangement, this disclosure contemplates any suitable mobile device having any suitable number of any suitable components in any suitable arrangement.", "In particular embodiments, processor 16 includes hardware for executing instructions, such as those making up a computer program or application.", "As an example and not by way of limitation, to execute instructions, processor 16 may retrieve (or fetch) the instructions from an internal register, an internal cache, memory 18, or storage 22; decode and execute them; and then write one or more results to an internal register, an internal cache, memory 18, or storage 22.In particular embodiments, processor 16 may include one or more internal caches for data, instructions, or addresses.", "This disclosure contemplates processor 16 including any suitable number of any suitable internal caches, where appropriate.", "As an example and not by way of limitation, processor 16 may include one or more instruction caches, one or more data caches, and one or more translation lookaside buffers (TLBs).", "Instructions in the instruction caches may be copies of instructions in memory 18 or storage 22, and the instruction caches may speed up retrieval of those instructions by processor 16.Data in the data caches may be copies of data in memory 18 or storage 22 for instructions executing at processor 16 to operate on; the results of previous instructions executed at processor 16 for access by subsequent instructions executing at processor 16 or for writing to memory 18 or storage 22; or other suitable data.", "The data caches may speed up read or write operations by processor 16.The TLBs may speed up virtual-address translation for processor 16.In particular embodiments, processor 16 may include one or more internal registers for data, instructions, or addresses.", "This disclosure contemplates a processor 16 including any suitable number of any suitable internal registers, where appropriate.", "Where appropriate, processor 16 may include one or more arithmetic logic units (ALUs); be a multi-core processor; or include one or more processors.", "Although this disclosure describes and illustrates a particular processor, this disclosure contemplates any suitable processor.", "In particular embodiments, software executed by processor 16 may include an operating system (OS).", "The OS may include a kernel or any number of device drivers corresponding to one or more hardware components of mobile device 10.As an example and not by limitation, if mobile device 10 is a smartphone, then the OS may be a mobile operating system, such as for example, WINDOWS Phone, ANDROID, SYMBIAN, IOS, or BADA.", "In particular embodiments, one or more software applications may be executed on mobile device 10.In particular embodiments, the applications may be native applications installed and residing on mobile device 10.As an example and not by way of limitation, an application (e.g.", "GOOGLE MAPS) may display a map on a touch screen, search for addresses and businesses, or provide directions to a geographic location; a second application may provide remote access to email; a third application (i.e.", "a web browser) may enable the device user to browse and search the Internet; a fourth application may control a camera to take photos or record videos; and a fifth application may allow the device user to receive and initiate voice-over Internet Protocol (VoIP) or cellular network calls.", "The software applications may have a user interface (UI) and may implement one or more specific functionalities.", "The software applications may include one or more software modules implementing the specific functionalities.", "The executable code of the software applications may be stored in memory 18 or storage 22 of mobile device 10.In particular embodiments, memory 18 includes main memory for storing instructions for processor 16 to execute or data for processor 16 to operate on.", "As an example and not by way of limitation, mobile device 10 may load instructions from storage 22 or another source (such as, for example, another mobile device 10) to memory 18.Processor 16 may then load the instructions from memory 18 to an internal register or internal cache.", "To execute the instructions, processor 16 may retrieve the instructions from the internal register or internal cache and decode them.", "During or after execution of the instructions, processor 16 may write one or more results (which may be intermediate or final results) to the internal register or internal cache.", "Processor 16 may then write one or more of those results to memory 18.In particular embodiments, processor 16 executes only instructions in one or more internal registers or internal caches or in memory 18 (as opposed to storage 22 or elsewhere) and operates only on data in one or more internal registers or internal caches or in memory 18 (as opposed to storage 22 or elsewhere).", "One or more memory buses (which may each include an address bus and a data bus) may couple processor 16 to memory 18.Bus 26 may include one or more memory buses, as described below.", "In particular embodiments, one or more memory management units (MMUs) reside between processor 16 and memory 18 and facilitate accesses to memory 18 requested by processor 16.In particular embodiments, memory 18 includes random-access memory (RAM).", "This RAM may be volatile memory, where appropriate Where appropriate, this RAM may be dynamic RAM (DRAM) or static RAM (SRAM).", "Moreover, where appropriate, this RAM may be single-ported or multi-ported RAM.", "This disclosure contemplates any suitable RAM.", "Memory 18 may include one or more memories, where appropriate.", "Although this disclosure describes and illustrates particular memory, this disclosure contemplates any suitable memory.", "In particular embodiments, storage 22 includes mass storage for data or instructions.", "As an example and not by way of limitation, storage 22 may include a hard-disk drive (HDD), a floppy disk drive, flash memory, or a combination of two or more of these.", "Storage 22 may include removable or non-removable (or fixed) media, where appropriate.", "Storage 22 may be internal or external to mobile device 10, where appropriate.", "In particular embodiments, storage 22 is non-volatile, solid-state memory.", "In particular embodiments, storage 22 includes read-only memory (ROM).", "Where appropriate, this ROM may be mask-programmed ROM, programmable ROM (PROM), erasable PROM (EPROM), electrically erasable PROM (EEPROM), electrically alterable ROM (EAROM), or flash memory or a combination of two or more of these.", "This disclosure contemplates mass storage 22 taking any suitable physical form.", "Storage 22 may include one or more storage control units facilitating communication between processor 16 and storage 22, where appropriate.", "Where appropriate, storage 22 may include one or more storages 22.Although this disclosure describes and illustrates particular storage, this disclosure contemplates any suitable storage.", "In particular embodiments, I/O interface 24 includes hardware, software, or both providing one or more interfaces for communication between mobile device 10 and one or more I/O devices.", "Mobile device 10 may include one or more of these I/O devices, where appropriate.", "One or more of these I/O devices may enable communication between a user and mobile device 10.As an example and not by way of limitation, an I/O device may include a keyboard, keypad, one or more sensors, touch screen, microphone, monitor, mouse, printer, scanner, speaker, digital still camera, stylus, trackball, video camera, another suitable I/O device or a combination of two or more of these.", "This disclosure contemplates any suitable I/O devices and any suitable I/O interfaces 24 for them.", "Where appropriate, I/O interface 24 may include one or more device or software drivers enabling processor 16 to drive one or more of these I/O devices.", "I/O interface 24 may include one or more I/O interfaces 24, where appropriate.", "Although this disclosure describes and illustrates a particular I/O interface, this disclosure contemplates any suitable I/O interface.", "In particular embodiments, communication component 20 includes hardware, software, or both providing one or more interfaces for communication (such as, for example, packet-based communication) between mobile device 10 and one or more other mobile devices 10 or one or more networks.", "As an example and not by way of limitation, communication component 20 may include a network interface controller (NIC) or network adapter for communicating with an Ethernet or other wire-based network or a wireless NIC (WNIC), wireless adapter for communicating with a wireless network, such as for example a WI-FI network or modem for communicating with a cellular network, such third generation mobile telecommunications (3G), or Long Term Evolution (LTE) network.", "This disclosure contemplates any suitable network and any suitable communication component 20 for it.", "As an example and not by way of limitation, mobile device 10 may communicate with an ad hoc network, a personal area network (PAN), a LAN, a WAN, a MAN, or one or more portions of the Internet or a combination of two or more of these.", "One or more portions of one or more of these networks may be wired or wireless.", "As another example, mobile device 10 may communicate with a wireless PAN (WPAN) (such as, for example, a BLUETOOTH WPAN), a WI-FI network, a WI-MAX network, a cellular telephone network (such as, for example, a Global System for Mobile Communications (GSM), 3G, or LTE network), or other suitable wireless network or a combination of two or more of these.", "Mobile device 10 may include any suitable communication component for any of these networks, where appropriate.", "Communication component 20 may include one or more communication components, where appropriate.", "Although this disclosure describes and illustrates a particular communication component, this disclosure contemplates any suitable communication component.", "In particular embodiments, bus 26 includes hardware, software, or both coupling components of mobile device 10 to each other.", "As an example and not by way of limitation, bus 26 may include a graphics bus, an Enhanced Industry Standard Architecture (EISA) bus, a front-side bus (FSB), a HYPERTRANSPORT (HT) interconnect, an Industry Standard Architecture (ISA) bus, an INFINIBAND interconnect, a low-pin-count (LPC) bus, a memory bus, a Micro Channel Architecture (MCA) bus, a serial advanced technology attachment (SATA) bus, a Video Electronics Standards Association local (VLB) bus, or another suitable bus or a combination of two or more of these.", "Bus 26 may include one or more buses 26, where appropriate.", "Although this disclosure describes and illustrates a particular bus, this disclosure contemplates any suitable bus or interconnect.", "Herein, a computer-readable non-transitory storage medium or media may include one or more semiconductor-based or other integrated circuits (ICs) (such, as for example, field-programmable gate arrays (FPGAs) or application-specific ICs (ASICs)), hard disk drives (HDDs), hybrid hard drives (HHDs), optical discs, optical disc drives (ODDs), magneto-optical discs, magneto-optical drives, floppy diskettes, floppy disk drives (FDDs), magnetic tapes, solid-state drives (SSDs), RAM-drives, SECURE DIGITAL cards or drives, any other suitable computer-readable non-transitory storage media, or any suitable combination of two or more of these, where appropriate.", "A computer-readable non-transitory storage medium may be volatile, non-volatile, or a combination of volatile and non-volatile, where appropriate.", "Herein, “or” is inclusive and not exclusive, unless expressly indicated otherwise or indicated otherwise by context.", "Therefore, herein, “A or B” means “A, B, or both,” unless expressly indicated otherwise or indicated otherwise by context.", "Moreover, “and” is both joint and several, unless expressly indicated otherwise or indicated otherwise by context.", "Therefore, herein, “A and B” means “A and B, jointly or severally,” unless expressly indicated otherwise or indicated otherwise by context.", "This disclosure encompasses all changes, substitutions, variations, alterations, and modifications to the example embodiments herein that a person having ordinary skill in the art would comprehend.", "Moreover, although this disclosure describes and illustrates respective embodiments herein as including particular components, elements, functions, operations, or steps, any of these embodiments may include any combination or permutation of any of the components, elements, functions, operations, or steps described or illustrated anywhere herein that a person having ordinary skill in the art would comprehend.", "Furthermore, reference in the appended claims to an apparatus or system or a component of an apparatus or system being adapted to, arranged to, capable of, configured to, enabled to, operable to, or operative to perform a particular function encompasses that apparatus, system, component, whether or not it or that particular function is activated, turned on, or unlocked, as long as that apparatus, system, or component is so adapted, arranged, capable, configured, enabled, operable, or operative." ] ]
Patent_15876055
[ [ "DISPLAY DEVICE", "A display device is configured to show an image inside a vehicle, and mounted inside the vehicle as an internal component.", "The display device has a light source configured to emit light, and a light guide element configured to guide incident light from the light source.", "The light guide element includes an emission surface configured to output incident light, and a plurality of light focusing portions configured to change the path of the incident light toward the emission surface, causing the light output to converge toward a convergence point or convergence line outside the light guide element or to radiate from a convergence point or convergence line outside the light guide element and thereby form an image outside the light guide element." ], [ "1.A display device configured to show an image inside a vehicle, and mounted inside the vehicle as an internal component, the display device comprising: a light source configured to emit light; and a light guide element configured to guide incident light from the light source, wherein the light guide element comprises: an emission surface configured to output incident light, and a plurality of light focusing portions configured to change the path of the incident light toward the emission surface, causing the light output to converge toward a convergence point or convergence line outside the light guide element or to radiate from a convergence point or convergence line outside the light guide element and thereby form an image outside the light guide element.", "2.The display device according to claim 1, wherein the light focusing portions are configured to form an image on a virtual plane oblique or orthogonal to the emission surface.", "3.The display device according to claim 1, wherein the light guide element is arranged at the upper part of a dashboard with the emission surface oriented upward, and wherein the light focusing portions are configured to form an image above the dashboard.", "4.The display device according to claim 1, wherein the light guide element is configured for arrangement on a window surface of the vehicle with the emission surface oriented toward inside the vehicle.", "5.The display device according to claim 1, wherein the light guide element is configured for arrangement on an internal component of the vehicle including at least one of a glove box, a center console, an arm rest, a door trim, a container trim, and a front seat.", "6.The display device according to claim 1, wherein the light focusing portions are configured to form an image at a position visible from a driver seat.", "7.The display device according to claim 1, wherein the light focusing portions are configured to form an image at a position visible from a seat behind the driver seat.", "8.The display device according to claim 1, wherein the light focusing portions are configured to form an image for presentation of an image representing at least one of a vehicle state, a vehicle ridership state, and a vehicle operation state.", "9.A display device mounted in a conveyance and configured to show an image inside the conveyance; the display device comprising: a light source configured to emit light; and a light guide element configured to guide incident light from the light source, wherein the light guide element comprises: an emission surface configured to output incident light, and a plurality of light focusing portions configured to change the path of the incident light toward the emission surface, causing the light output to converge toward a convergence point or convergence line outside the light guide element or to radiate from a convergence point or convergence line outside the light guide element and thereby form an image outside the light guide element.", "10.The display device according to claim 2, wherein the light guide element is arranged at the upper part of a dashboard with the emission surface oriented upward, and wherein the light focusing portions are configured to form an image above the dashboard.", "11.The display device according to claim 2, wherein the light guide element is configured for arrangement on a window surface of the vehicle with the emission surface oriented toward inside the vehicle.", "12.The display device according to claim 2, wherein the light guide element is configured for arrangement on an internal component of the vehicle including at least one of a glove box, a center console, an arm rest, a door trim, a container trim, and a front seat.", "13.The display device according to claim 2, wherein the light focusing portions are configured to form an image at a position visible from a driver seat.", "14.The display device according to claim 3, wherein the light focusing portions are configured to form an image at a position visible from a driver seat.", "15.The display device according to claim 4, wherein the light focusing portions are configured to form an image at a position visible from a driver seat.", "16.The display device according to claim 5, wherein the light focusing portions are configured to form an image at a position visible from a driver seat.", "17.The display device according to claim 2, wherein the light focusing portions are configured to form an image at a position visible from a seat behind the driver seat.", "18.The display device according to claim 3, wherein the light focusing portions are configured to form an image at a position visible from a seat behind the driver seat.", "19.The display device according to claim 4, wherein the light focusing portions are configured to form an image at a position visible from a seat behind the driver seat.", "20.The display device according to claim 5, wherein the light focusing portions are configured to form an image at a position visible from a seat behind the driver seat." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>However, given the large variety of content, such as warning lights which may be presented on the instrument panel, the panel design and the individual warning lights may be given a size and a position that are hard to see.", "Selecting a size and a position that improves the visibility of the warning lights, and the like may then lead to limiting the design of the panel.", "However, limits to designing the panel remain despite providing the vehicle display device described in Japanese Patent Publication No.", "2006-214757 with a multifunction display unit capable of presenting details and providing a warning display unit that lists all the plurality of warning indicators that may be presented thereon individually.", "One or more embodiments of the present invention provides a display device as an internal component, the display device equipped with a light guide element capable of changing an optical path to form an image externally which improves flexibility in designing other components in an instrument panel and the like and improves visibility.", "A display device according to one or more embodiments of the present invention is configured to show an image inside a vehicle, and is mounted inside the vehicle as an internal component.", "The display device includes a light source configured to emit light; and a light guide element configured to guide incident light from the light source; the light guide element including: an emission surface configured to output incident light; and a plurality of light focusing portions configured to change the path of the incident light toward the emission surface, causing the light output to converge toward a convergence point or convergence line outside the light guide element or to radiate from a convergence point or convergence line outside the light guide element and thereby form an image outside the light guide element.", "In the display device described herein the light focusing portions are configured to form an image on a virtual plane oblique or orthogonal to the emission surface.", "In the display device described herein the light guide element is arranged at the upper part of a dashboard with the emission surface oriented upward; and the light focusing portions form an image above the dashboard.", "In the display device described herein the light guide element is configured for arrangement on a window surface of the vehicle with the emission surface oriented toward inside the vehicle.", "In the display device described herein the light guide element is configured for arrangement on an internal component of the vehicle including at least one of a glove box, a center console, an arm rest, a door trim, a container trim, and a front seat.", "In the display device described herein the light focusing portions are configured to form an image at a position visible from a driver seat.", "In the display device described herein the light focusing portions are configured to form an image at a position visible from a driver seat behind the driver seat.", "In the display device described herein the light focusing portions are configured to form an image for presentation of an image representing at least one of the vehicle state, a vehicle ridership state, and a vehicle operation state.", "A display device described herein may be mounted in a conveyance and configured to show an image inside the conveyance; and includes: a light source configured to emit light; and a light guide element configured to guide incident light from the light source; the light guide element including: an emission surface configured to output incident light; and a plurality of light focusing portions configured to change the path of the incident light toward the emission surface, causing the light output to converge toward a convergence point or convergence line outside the light guide element or to radiate from a convergence point or convergence line outside the light guide element and thereby form an image outside the light guide element.", "The display device described herein is capable of presenting an image formed inside a conveyance such as a passenger vehicle." ], [ "BACKGROUND Field The present invention relates to a display device for displaying an image that serves as an internal component of a conveyance such as an automobile.", "Related Art A variety of warning lights may be included in a panel (instrument panel) arranged inside a vehicle such as a passenger car to provide notifications on the vehicle state.", "The content of the warnings provided by an arrangement of warning lights tend to be shown in small hard-to-see areas regardless of the importance of the information to be presented.", "For instance, Japanese Patent Publication No.", "2006-214757 discloses a vehicle display device provided with a warning display unit and multifunction display unit; the warning display unit lists all the plurality of warning indicators that may be presented thereon individually, while the multifunction display unit can present details for a plurality of warnings.", "The vehicle display device shows the relevant warning indicator on the warning display unit when showing the details of the warning on the multifunction display unit.", "SUMMARY However, given the large variety of content, such as warning lights which may be presented on the instrument panel, the panel design and the individual warning lights may be given a size and a position that are hard to see.", "Selecting a size and a position that improves the visibility of the warning lights, and the like may then lead to limiting the design of the panel.", "However, limits to designing the panel remain despite providing the vehicle display device described in Japanese Patent Publication No.", "2006-214757 with a multifunction display unit capable of presenting details and providing a warning display unit that lists all the plurality of warning indicators that may be presented thereon individually.", "One or more embodiments of the present invention provides a display device as an internal component, the display device equipped with a light guide element capable of changing an optical path to form an image externally which improves flexibility in designing other components in an instrument panel and the like and improves visibility.", "A display device according to one or more embodiments of the present invention is configured to show an image inside a vehicle, and is mounted inside the vehicle as an internal component.", "The display device includes a light source configured to emit light; and a light guide element configured to guide incident light from the light source; the light guide element including: an emission surface configured to output incident light; and a plurality of light focusing portions configured to change the path of the incident light toward the emission surface, causing the light output to converge toward a convergence point or convergence line outside the light guide element or to radiate from a convergence point or convergence line outside the light guide element and thereby form an image outside the light guide element.", "In the display device described herein the light focusing portions are configured to form an image on a virtual plane oblique or orthogonal to the emission surface.", "In the display device described herein the light guide element is arranged at the upper part of a dashboard with the emission surface oriented upward; and the light focusing portions form an image above the dashboard.", "In the display device described herein the light guide element is configured for arrangement on a window surface of the vehicle with the emission surface oriented toward inside the vehicle.", "In the display device described herein the light guide element is configured for arrangement on an internal component of the vehicle including at least one of a glove box, a center console, an arm rest, a door trim, a container trim, and a front seat.", "In the display device described herein the light focusing portions are configured to form an image at a position visible from a driver seat.", "In the display device described herein the light focusing portions are configured to form an image at a position visible from a driver seat behind the driver seat.", "In the display device described herein the light focusing portions are configured to form an image for presentation of an image representing at least one of the vehicle state, a vehicle ridership state, and a vehicle operation state.", "A display device described herein may be mounted in a conveyance and configured to show an image inside the conveyance; and includes: a light source configured to emit light; and a light guide element configured to guide incident light from the light source; the light guide element including: an emission surface configured to output incident light; and a plurality of light focusing portions configured to change the path of the incident light toward the emission surface, causing the light output to converge toward a convergence point or convergence line outside the light guide element or to radiate from a convergence point or convergence line outside the light guide element and thereby form an image outside the light guide element.", "The display device described herein is capable of presenting an image formed inside a conveyance such as a passenger vehicle.", "Effects Embodiments of the present invention are provided as internal components and include a light source and a light guide element, and the light guide element uses incident light entering therein from the light source to form an image externally.", "Hereby, the display device can thereby show display content such as various warning lights and the like outside the device, and for instance, in a space above a dashboard.", "Accordingly, the display device exhibits superior benefits such as, allowing other internal components to be designed without, for instance, being adversely limited by the instrument panel design and reducing constraints on the design of other components while providing better visibility.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is for describing a display device according to embodiments of the present invention and schematically illustrates the display device along with an image formed in a space; FIG.", "2 is a conceptual diagram outlining a cross section of the display device according to embodiments of the present invention and an optical path; FIG.", "3 is a conceptual diagram outlining a cross section of the display device according to embodiments of the present invention and an optical path; FIG.", "4 is a schematic view illustrating around the driver seat in a vehicle provided with a display device according to the first embodiment of the present invention mounted therein as an internal component; FIG.", "5 is a schematic cross-sectional view illustrating around the drivers seat and includes a driver in a vehicle provided with a display device according to the first embodiment of the present invention mounted therein as an internal component; FIG.", "6A and FIG.", "6B are schematic diagrams for describing the relationship between an emission surface of the display device according to the first embodiment of the present invention and an image; FIG.", "7 is a schematic view illustrating near the drivers seat in a vehicle cabin provided with a display device according to a second embodiment of the present invention mounted therein as an internal component; FIG.", "8 is a schematic cross-sectional view illustrating around the driver seat and includes a driver in a vehicle provided with a display device according to the second embodiment of the present invention mounted therein as an internal component; and FIG.", "9 is a schematic view illustrating near the rear passenger seat in a vehicle cabin provided with a display device according to a third embodiment of the present invention mounted therein as an internal component.", "DETAILED DESCRIPTION Embodiments of the present invention are described in detail with reference to the drawings.", "Note that the following working example is merely an embodiment of the present invention and in no way limits the technical character of the present invention.", "The display device according to embodiments of the present invention focuses light in a space inside a conveyance, e.g., vehicle such as a passenger car, and produces an image therein.", "First, the principle of producing an image in a space is described.", "FIG.", "1 is for describing a display device according to embodiments of the present invention and schematically illustrates the display device along with an image farmed in a space.", "Note that the drawings are provided as outlines or schematic views to facilitate a simple and easy-to-understand description.", "There are also cases where the drawings referenced in the description contain elements that are not drawn to scale in terms of the horizontal and vertical proportions or the spaces between components.", "The light emitting device 1 is provided with a light source 10 that emits light and a light guide plate 11 (light guide element) that guides the incident light from the light source 10.The light source 10 may be configured using a light emitting element such as an LED with the light emitted from the light source 10 entering the light guide plate 11.The light guide plate 11 may be formed from a flexible thin-film material or curable sheet into a rectangular panel-like shape using a transparent resin having a high refractive index such as a polycarbonate (PC) resin or poly methyl methacrylate (PMMA) resin, or using an inorganic material such as glass.", "Here “panel like” indicates an object that is shorter (thinner) in the thickness direction (Z axis direction) than in the planar direction spreading out in two dimensions (XY plane) orthogonal to the thickness direction.", "That is, while the light guide plate 11 is a rectangular parallelepiped, the length thereof in the thickness direction (Z axis direction) is less than the length in a plane spreading out in two dimensions and formed by the longitudinal direction (X axis direction) and the transverse direction (Y axis direction).", "The light source 10 is installed at one end surface in the longitudinal direction of the light guide plate 11.That is, one of the surfaces making up the short side of the rectangle in the thickness direction is the incidence end surface 12 where light emitted from the light source 10 enters.", "The light guide plate 11 causes light entering therein from the incidence end surface to spread out in planar form.", "The panel-like light guide plate 11 includes an emission surface 13 configured to emit incident light entering from the light source 10 and a rear surface 14 relative to and across from the emission surface 13.In the description that follows, the rectangular coordinate system, and in particular the right-handed system of x axis, y axis, and z axis is used as necessary.", "The X axis is the transverse direction of the light guide plate 11, i.e., the direction along the short side of the rectangle.", "The Y axis is the longitudinal direction of the light guide plate 11, i.e., the direction along the long side of the rectangle, where the direction from the incidence end surface 12 toward the end surface facing the incidence end is the positive direction.", "The Z axis is the thickness direction of the light guide plate 11, where the direction from the rear surface 14 to the emission surface 13 is the positive direction.", "The light guide plate 11 may be used in a non-planar way, e.g., may be bent for use.", "In this case, the surface including the main portion of the emission surface 13 or a neighboring surface may be used as a reference for the X axis, Y axis, and Z axis.", "A plurality of light focusing portions 15 is formed on the rear surface 14 of the light guide plate 11; the light focusing portions 15 are represented as light focusing portions 15a, 15b, 15c, .", ".", ".", "in the drawings.", "The light focusing portions 15 are situated along the progressive path of incident light entering from the incidence end surface; that is, the light focusing portions 15 adjust the optical path of the incident light toward the emission surface 13.Here, the light focusing portions 15 are illustrated as optical surfaces formed inside the light guide plate 11, and in this particular case, as reflection surfaces 150 (FIG.", "2: 150x, 150y; and FIG.", "3: 150x1, 150x2, 150x3) that reflect incident light entering from the incidence end surface 12.Oblique notches may be cut into the rear surface 14 with the inclined surfaces serving as the reflection surfaces 150.The reflection surfaces 150 of the light focusing portions 15 are formed as substantially continuous in the X axis direction.", "More specifically, the plurality of light focusing portions 15a, 15a, .", ".", ".", "fall along a line 16a, and the plurality of light focusing portions 15b, 15b, .", ".", ".", "fall along a line 16b.", "The plurality of light focusing portions 15c, 15d, .", ".", ".", ", 15g fall along lines 16c, 16d, .", ".", ".", ", line 16g respectively in the same manner.", "Here the lines 16 (lines 16a, 16b, .", ".", ".", ", 16g)are virtual straight lines extending substantially parallel to the X axis on the rear surface 14.Any given light focusing portion 15, 15, .", ".", ".", "is formed as substantially continuous along a straight line 16 that is substantially parallel to the X axis direction.", "The incident light entering the light guide plate 11 is guided toward the light focusing portions 15, 15, .", ".", ".", "lined up along the X axis direction.", "The light focusing portions 15 include components such as the reflection surfaces 150 for changing the optical path.", "The reflection surface 150 in a light focusing portion 15 changes the path of incident light causing the light to exit from the emission surface 13 and substantially converge at convergence point P corresponding to the light focusing portion 15.FIG.", "1 depicts a portion of the light focusing portions 15, namely, light focusing portions 15a, 15b, .", ".", ".", ", 15g; more specifically, FIG.", "1 depicts the plurality of light rays with paths changed by each of the light focusing portions 15a, 15b, .", ".", ".", ", 15g converging at convergence points Pa, Pb, .", ".", ".", ", Pg respectively.", "Each of the light focusing portions 15 cause the light rays to converge at convergence points P to form an image, thus forming an image 17.More specifically, the plurality of light focusing portions 15 on any of the lines 16a, 16b, .", ".", ".", "may correspond to a convergence point P in the image 17.The plurality of light focusing portions 15 in any given line 16 may change the optical path of the light rays emanating from the positions of the light focusing portions 15 when light reflects from the optical surfaces, e.g., from the reflection surfaces 150; hereby the light rays exit from the emission surface 13 and converge at a convergence point P. Therefore, the wavefront of light from the plurality of light focusing portions 15 becomes a wavefront that appears to radiate from the convergence point P. For example, the plurality of light focusing portions 15a on the line 16a corresponds to a convergence point Pa in the image 17.The light focusing portions 15a change the optical path of the light rays guided toward the plurality of light focusing portions 15a on the line 16a, and thus the light rays exit from the emission surface 13 and converge at the convergence point Pa. Light reflected by the plurality of light focusing portions 15 along other lines 16 converges identically at convergence points P. Thus, any desired light focusing portion 15 can provide a wavefront of light so that light appears to radiate from the corresponding convergence point P. The convergence points P correspond to mutually different light focusing portions 15.A grouping of a plurality of convergence points P that correspond to each of the light focusing portions 15 produces a recognizable image 17 in a space.", "The display device 1 thus projects the image 17 as a three-dimensional image in a space.", "The image 17 depicted in FIG.", "1 is drawn as a three-dimensional image with lines; the lines used to draw the image 17 are produced by grouping a plurality of convergence points P corresponding to each of the light focusing portions 15.The display device 1 forms an image with light exiting from the emission surface 13 to produce the image 17 as a spectroscopic image.", "The image 17 is a spectroscopic image that may be recognized in a space by an observer.", "Note that in this specification, the term spectroscopic image refers to an image 17 that appears to be at a location that is different from the emission surface 13 external to the display device 1.The term spectroscopic image is not limited to a three-dimensional image and includes a two-dimensional image perceived at a location separate from the efficient surface 13 of the display device 1, for instance.", "In other words the term “spectroscopic image” does not refer only to an image perceived as having a solid shape, but also includes the image 17 in two-dimensional form perceived at a different location than on emission surface 13 of the display device 1 and represents an image 17 that appears to be protruding from the light guide plate 11 of the display device 1.The light guided by the light guide plate 11 is oriented in a direction connecting locations in the light guide plate 11 and the light source 10 while not including a spread component orthogonal to a direction connecting locations in the light guide plate 11 and the light source 10.The light focusing portions 15 may be provided at locations separated from the light source 10; in this case, the light guided by the light guide plate 11 is oriented generally towards the Y axis direction from the location at which the light focusing portion is provided but does not spread in the X axis direction.", "Therefore, light from the light focusing portion 15 substantially converges onto a single convergence point P in a plane parallel to the XZ plane that includes the convergence point P. When light entering the light focusing portions 15 spread in the Z axis direction, the light from the light focusing portions 15 converge on a convergence line along the Y axis in a space containing the convergence point P. However, the description of the embodiment focuses on the convergence of light in the XZ plane to facilitate understanding of the embodiment and describes the same as light from the light focusing portions 15 converging on the convergence points P. FIGS.", "2 and 3 are conceptual diagrams outlining a cross section of the display device according to embodiments of the present invention and an optical path; FIG.", "2 illustrates a cross-section parallel to the YZ plane, and FIG.", "3 also illustrates the image 17 viewed by an observer of a cross-section parallel to the XZ plane.", "FIG.", "2 and FIG.", "3 illustrates not only the emission surface 13 of the light guide plate 11 (i.e., the positive Z axis direction), but also provides an example of the image 17 representing an arrow that also spreads at the rear surface 14 (negative Z axis direction).", "In the examples illustrated in FIG.", "2 and FIG.", "3, the image 17, which represents an arrow, appears with the front portion of the arrow protruding from the emission surface 13 and the rear portion of the arrow protruding from the rear surface 14.As illustrated in FIG.", "2, the light source 10 is installed at the incidence end surface 12 of the light guide plate 11, and the incidence end surface 12 and the emission surface 13 are substantially orthogonal.", "Additionally, the rear surface 14 faces the emission surface 13, and the rear surface 14 is also substantially orthogonal to the incidence end surface 12.The rear surface 14 is a flat surface substantially parallel to the emission surface 13 and is provided with inclined surfaces that form the reflection surfaces 150 (150x, 150y) of the light focusing portions 15.The flat rear surface 14 along with the emission surface 13 directs the incident light entering the light guide plate 12 from the incidence end surface 11 via total internal reflection therebetween and function to spread the light in the light guide plate 11 in planar form.", "The inclined reflection surfaces 150 of the light focusing portions 15 reflect the incident light entering the light guide plate 11 to thereby adjust the optical path of the light toward the emission surface 13.That is, the light emitted from the light source 10 and entering the light guide plate 11 from the incidence and surface 12 is repeatedly totally reflected between the emission surface 13 and the rear surface 14 within the light guide plate 11 and propagates therethrough in planar form.", "On arriving at a reflection surface 150 formed in the light focusing portion 15, the light propagating through the light guide plate 11 is reflected by the reflection surface 150 and exits to the outside from the emission surface 13.As illustrated in FIG.", "2 and FIG.", "3, the plurality of light focusing portions 15x(light focusing portions 15x1, 15x2, 15x3, .", ".", ". )", "located on a line 16 include reflection surfaces 150x1, 150x2, 150x3, .", ".", ".", ", respectively.", "The reflection surfaces 150x1, 150x2, 150x3, .", ".", ".", "corresponding to the plurality of light focusing portions 15x located along the line 16 reflect light toward the emission surface 13 in a direction converging at a convergence point P1 near the emission surface 13.A plurality of light focusing portions 15y (light focusing portions 15y1,15y2, 15y3, .", ".", ". )", "is located on another line 16 and also include reflection surfaces 150y1, 150y2, 150y3, .", ".", ".", ", respectively.", "The reflection surfaces 150y1, 150y2, 150y3 corresponding to the plurality of light focusing portions 15y located along the other line 16 reflect light toward the emission surface 13 toward a direction where the light radiates from a convergence point P2 near the rear surface 14.Therefore, the incline of the reflection surface 150y2 of the light focusing portion 15y2 and the reflection surface 150y3 of the light focusing portion 15y3 (written in parenthesis in FIG.", "3) are the opposite direction in FIG.", "3 and are inclined toward the end surface of the light guide plate 11.The reflection surfaces 150x (e.g., the reflection surfaces 150x1, 150x2, 150x3, .", ".", ". )", "each reflects light from the light source 10 in a direction along a line connecting a point on each of the reflection surfaces 150x and the convergence point P1.The light rays reflected from the reflection surfaces 150x converge at the convergence point P1.Thus, the plurality of reflection surfaces 150x in corresponding light focusing portions 15x reflects incident light entering from the light source 10 in a direction along a line connecting a point on each of the reflection surfaces 150x and the convergence point P1.Therefore, the display device 1 can supply light from the convergence point P1 oriented toward any of the positions in a range from a position V2 through a position V1 and up to position V3.A convergence point P1 of this kind produces the image 17 which appears to protrude from near the emission surface 13.The reflection surfaces 150y (e.g., the reflection surfaces 150y1, 150y2, 150y3, .", ".", ". )", "each reflects incident light entering from the light source 10 in a direction along a line connecting a point on each of the reflection surfaces 150y and the convergence point P2.The light rays reflected from the reflection surfaces 150y may be extended in a direction opposite the direction the light rays travel, in which case the extension line from the light rays converge at the convergence point P2.Thus, the plurality of reflection surfaces 150y in corresponding light focusing portions 15y reflects incident light entering from the light source 10 in a direction along a line connecting a point on each of the reflection surfaces 150y and the convergence point P2.Therefore, the display device 1 can supply light from the convergence point P2 oriented toward any of the positions in a range from a position V2 through a position V1 and up to position V3.A convergence point P2 of this kind produces the image 17 which appears to protrude from the opposite side of emission surface 13 (i.e., near the rear surface 14).", "As above described, the light guide plate 11 includes a plurality of light focusing portions 15 having mutually different convergence points P, where a grouping of a plurality of convergence point P including a convergence point P1 and a convergence point P2 produces an image 17 that serves as a stereoscopic image.", "That is, the light guide plate 11 is provided with a plurality of light focusing portions 15 which change the path of incidence light toward an emission surface 13 causing the light output to converge toward an external convergence point or convergence line or to radiate from an external convergence point or convergence line and thereby form an image externally.", "By grouping a plurality of convergence points P and convergence lines, the display device 1 can thus form an image 17 outside the light guide plate 11 that can be perceived by an observer as a stereoscopic image.", "In other words, the following kinds of statements can be made.", "Light emitted from a light source 10 enters a light guide plate 11, and the light guide plate 11 guides light within a plane parallel to the emission surface 13.A plurality of light focusing portions 15 is formed on the light guide plate 11; the light focusing portions 15 lengthen in a direction (i.e., the X axis direction) orthogonal to the direction (Y axis direction) in which the light guide plate guides light within a plane parallel to the emission surface 13.Each of the light focusing portions 15 includes optical surfaces where the direction of the normal line thereof projected onto a surface parallel to the emission surface varies continuously or gradually along the length direction (X axis direction) of the light focusing portions 15.The light guided by the light guide plate 11 reflects from the optical surfaces whereby the light exits as emission light from the emission surface 13 in a direction to substantially converge on a single convergence point P or convergence line in a space, or to substantially radiate from a single convergence point P or convergence line.", "The convergence points P or convergence lines are mutually different for the plurality of light focusing portions 15 at different positions along the Y axis, and grouping a plurality of convergence points P or convergence lines produces an image 17 in a space.", "FIG.", "2 and FIG.", "3 and the corresponding descriptions illustrate a stereoscopic image that appears to protrude from both the emission surface 13 and the rear surface 14; this is used to describe the basic principles behind producing a stereoscopic image.", "However, as illustrated in FIG.", "1 the stereoscopic image may appear to protrude from near only one surface.", "The reflection surfaces 150 here serve as the light focusing portions 15.However, the light focusing portions 15 can have various forms so long as the light focusing portions 15 can change the path of incident light traveling through the light guide plate 11.For instance, the light focusing portion 16 may be formed as a cylindrical Fresnel lens, whereby the refraction effect of the refraction surface of the Fresnel lens (i.e.", "the prism surface) changes the path of the incident light.", "Additionally, in this case the Fresnel lens may be constituted by a plurality of parts with gaps therebetween.", "The light focusing portions 15 may also be formed as a diffraction grating whereby the diffraction effect may change the path of the incident light.", "Moreover, the reflection effect and the refraction effect of the prism may change the optical path of the incident light.", "Additionally, the distances between all the convergence points P and emission surface 13 may be non-uniform.", "In this case, the density of converging light is configured to increase as the distance from the emission surface 13 increases when forming an image 17 that spreads for instance three dimensionally, or when forming a two-dimensional image 17 that contains a plane obliquely intersecting the emission surface 13.Hereby, any blurring in the image 17 formed is substantially uniform, making it possible to create an image 17 that does not make the observer uneasy.", "Furthermore, while the light emitted from the light source 10 is represented as incident light entering the light guide plate 11 from the incidence end surface 12, which is one in surface in the longitudinal direction of the light guide plate 11, the incident light is not limited thereto.", "For example, the rear surface 14 may be taken as the light incidence surface and appropriately designed so that light enters the light guide plate therefrom.", "First Embodiment A display device 1 thusly configured according embodiments of the present invention may be installed as an internal vehicle component; such an embodiment is described below.", "FIG.", "4 is a schematic view illustrating around the driver seat in a vehicle 2 provided with a display device according to the first embodiment of the present invention mounted therein as an internal component.", "The vehicle 2 in FIG.", "4 is a passenger vehicle.", "A display device 1 according to embodiments of the present invention is mounted in the vehicle 2 and the image 17 produced by the display device 1 is projected above a dashboard 20 provided in front of both the driver seat and the passenger seat.", "The projected image 17 presents various content such as the status of the vehicle 2, the status of the ridership, and the operation state of the vehicle 2.The projected image 17 presents a still image particularly for display states that are fixed.", "FIG.", "4 depicts images representing: the vehicle state, i.e., a brake warning indicator; a ridership state, i.e., an unbuckled seatbelt indicator showing whether the passenger seat or driver seat seatbelt is unbuckled, and the vehicle operation state, i.e., a gear position indicator (shown as “N”, FIG.", "4).", "These kinds of images 17 are not limited to the images illustrated in FIG.", "4 and may further include images representing, for instance, a water temperature indicator, a headlamp beam direction indicator, a fog light indicator, a four-wheel drive indicator, an engine warning indicator, an oil pressure warning indicator, a battery warning indicator, a fuel level warning indicator, an ABS warning indicator, an SRS warning indicator, and direction indicators.", "The gear shift position indicator is not limited to the “N” as depicted in FIG.", "4 but may also include images of other gear positions “P”, “R”, “D”, “2”, “L”, and the like, or may further include an image indicating the state of an overhead light.", "In FIG.", "4, the image 17 is presented enclosed in a thin square frame to provide a convenient illustration.", "The image 17 may in fact be shown as floating inside a square frame over a space including a rectangle represented by the square frame.", "FIG.", "5 is a schematic cross-sectional view illustrating around the drivers seat and includes a driver in a vehicle provided with a display device according to the first embodiment of the present invention mounted therein as an internal component; FIG.", "5 schematically illustrates a cross section parallel to the YZ plane.", "The display device 1 is arranged on the upper part of the dashboard 20 in the vehicle 2 so that the emission surface 13 in the light guide plate 11 is oriented upward.", "The light guide plate 11 in the display device 1 may be configured from a flexible transparent panel; the incidence end surface 12 at the end portion of the light guide plate 11 near the light source 10 or the opposite end may be bent and embedded in the dashboard 20.The light focusing portions 15 are formed in the flat middle section of the light guide plate 11; this flat middle section serves as the emission surface 13, and the emission surface 13 is oriented upward.", "The light source 10 is embedded in the dashboard 20 with the incidence end surface 12 attached thereto; the light source 10 is connected to a control device (not shown) in the vehicle 2 and emits light as appropriate on the basis of control from the control device.", "The light focusing portions 15 in the light guide plate 11 are configured to form images only upward.", "That is the light focusing portions 15 form an image above the dashboard 20 where it is embedded so that various planar images such as an image representing the position of the gearshift is formed along a virtual plane oblique or orthogonal to the emission surface 13.FIG.", "6A and FIG.", "6B are schematic diagrams for describing the relationship between an emission surface of the display device according to the first embodiment of the present invention and an image.", "FIG.", "6A is a schematic view illustrating the relationship between the emission surface 13 of the light guide plate 11 in the display device 1 and the image 17 that is formed; FIG.", "6B is a schematic side view.", "In FIG.", "6A and FIG.", "6B, the virtual plane created by the emission surface 13 and the image 17 slants at an angle θ.", "The image 17 is formed in a flat plane substantially orthogonal to the direction of an observer, i.e., the driver's gaze, and the image 17 is readily visible to the driver.", "Note that depending on the positioning of the light guide plate 11, the image 17 may be formed such that the angle θ is a right angle; that is the light guide plate 11 may be positioned so that the emission surface and the virtual plane are orthogonal.", "In addition, not all the images 17 need to be formed oriented toward the driver.", "For instance, the image of an unbuckled passenger seatbelt indicator may be formed in a plane substantially orthogonal to the direction of the observer's gaze, i.e.", "in the direction of a rider in the passenger seat.", "The installation location of the display device 1 in general, and of the light guide plate 11 in particular is not limited to the dashboard 20 as above described.", "As illustrated in FIG.", "4, the display device 1 may be arranged at various locations such as the cover of the glove box 21 in front of the drivers the passenger seat or thereabouts, the center console 22 between the drivers seat and the passenger seat, an armrest (not shown), and any site on the door trim 23 that is an internal door component.", "Riders in any seat such as the driver seat, the passenger seat, or the backseat can view an image 17 produced by the display device 1.A display device 1 thusly configured does not require warning lights to be arranged in the panel; therefore, this increases the flexibility in designing the panel, and in order to improve visibility of the warning lights displays allows images 17 of the appropriate size to be produced.", "Additionally, light guide plates 11 may be stacked for images that do not need to be displayed simultaneously, e.g., images showing the position of the gearshift to allow each gear position to be shown by switching the display at the same position.", "It is thus possible to minimize the space needed for display.", "Second Embodiment FIG.", "7 is a schematic view illustrating near the drivers seat in a vehicle cabin provided with a display device according to a second embodiment of the present invention mounted therein as an internal component.", "In the second embodiment, the image 17 created by the display device 1 is projected in front of the driver seat near the lower part of the front windshield 24 above the dashboard 20.The formed image 17 is identical to the image describes for the first embodiment using FIG.", "4; it is thus sufficient to reference the first embodiment for these configurations and so further descriptions thereof are omitted.", "In FIG.", "7, the image 17 is presented enclosed in a thin square frame to provide a convenient illustration.", "The image 17 may in fact be shown inside a square frame presented in a space including a rectangle represented by the square frame.", "FIG.", "8 is a schematic cross-sectional view illustrating around the driver seat and includes a driver in a vehicle provided with a display device according to the second embodiment of the present invention mounted therein as an internal component.", "FIG.", "8 schematically illustrates a cross section parallel to the YZ plane.", "The display device 1 is arranged on the lower part of the front windshield 24 in the vehicle 2 so that the emission surface 13 in the light guide plate 11 is oriented downward.", "The light guide plate 11 in the display device 1 may be configured from a flexible transparent panel; the incidence end surface 12 at the end portion of the light guide plate 11 near the light source 10 may be bent and embedded in the dashboard 20.The light focusing portions 15 are formed in a flat section of the light guide plate 11; this flat section serves as the emission surface 13, and the emission surface 13 is oriented downward.", "The light source 10 is embedded in the dashboard 20 with the incidence end surface 12 attached thereto; the light source 10 is connected to a control device (not shown) in the vehicle 2 and emits light as appropriate on the basis of control from the control device.", "The light focusing portions 15 in the light guide plate 11 are configured to form images only inside the vehicle.", "That is the light focusing portions 15 form an image near the lower part of the front windshield 24 (above the dashboard 20) so that various planar images such as an image representing the position of the gearshift is formed along a virtual plane oblique or orthogonal to the emission surface 13.The image 17 is formed in a flat plane substantially orthogonal to the direction of an observer, i.e., the driver's gaze, and the image 17 is readily visible to the driver.", "Not all the images 17 need to be formed oriented toward the driver.", "For instance, the image of an unbuckled passenger seatbelt indicator may be formed in a plane substantially orthogonal to the direction of the observer's gaze, i.e.", "in the direction of a rider in the passenger seat.", "Additionally, not all images 17 need to be produced inside the vehicle; all or a portion of the images may be formed outside the vehicle so long as visibility is not a problem.", "A display device 1 thusly configured exhibits superior benefits, such as increasing the flexibility in designing internal components for the vehicle 2 while providing the driver with important information.", "Third Embodiment FIG.", "9 is a schematic view illustrating near the rear passenger seat in a vehicle cabin provided with a display device according to a third embodiment of the present invention mounted therein as an internal component.", "In the third embodiment, the image 17 produced by the display device 1 is projected behind the head rest 25 of a front seat.", "The image 17 may be an unbuckled seat indicator for the backseat.", "For instance, the display device 1 may be installed at the rear part of the front seat head rest 25, the lower part of the seatback of the front seat 26, or the cabin ceiling whereby and image 17 is projected as depicted in FIG.", "9.The display device 1 may also be arranged at various locations such as the container trip (not shown) behind the back seat, or the door trim (not shown), which is an internal component of the rear door.", "The display device may be configured so that if an image 17 is produced for the rear part of the vehicle 2, then the image formed should be visible to riders in the back seat; and for example, the display device may be configured so that a driver seated in the driver seat can verify the image without looking toward the back.", "More specifically, when the gearshift is placed in reverse (i.e., “R”), a display device 1 in the container trim may show an image 17 for various indicators whereby various displays are presented, e.g., to represent the state of the vehicle 2 allowing the driver to recognize various kinds of information.", "The present invention is not limited to the above described embodiments and may be implemented in various other ways.", "Therefore, in all respects the above embodiments are merely examples and should not be interpreted as limitations.", "The scope of the present invention is delineated by the claims and not limited by the specification.", "Moreover, all modifications and variations with a scope equivalent to the claims are within the scope of the present invention.", "For example, the aforementioned embodiments illustrated producing images in a two-dimensional plane; however, the present invention is not limited thereto and may be developed into various forms where a three-dimensional image is produced.", "The aforementioned embodiments also illustrated arranging the display device on the surface of the front windshield 24; however, the present invention is not limited thereto, and may be configured such that the display device is arranged on other window surfaces such as the rear windshield or a side window or the like.", "Finally, the aforementioned embodiments depict a form that is mounted to a passenger vehicle.", "However, the display device may be mounted inside various other kinds of vehicles such as a train and may produce images inside the train.", "The display device may also be mounted inside other forms of conveyance besides a vehicle 2, such as in an airplane or on a ship, and produce images inside the conveyance.", "REFERENCE NUMERALS 1 Display device 10 Light source 11 Light guide plate (light guide element) 12 Incidence end surface 13 Emission surface 15 (15a, 15b, .", ".", ".", ", 15x1, .", ".", ".", ", 15y3) Light focusing portions 17 Image P (Pa, Pb, .", ".", ".", ", P1, P2) Convergence points 2 Vehicle 20 Dashboard 21 Glove box 22 Center console 23 Door trim 24 Front windshield 25 Head rest 26 Front seat" ] ]
Patent_15876056
[ [ "APPLICATION SPECIFIC INTEGRATED CIRCUIT LINK", "Systems and methods for application specific integrated circuit design using Chronos links are disclosed.", "A Chronos Link is an ASIC on-chip and off-chip interconnect communication protocol that allows interfaces to transmit and receive information.", "The protocol may utilize messages or signals to indicate the availability and/or readiness of information to be exchanged between a producer and a consumer allowing the communication to be placed on hold and to be resumed seamlessly.", "A method includes inserting gaskets and channel repeaters connected to interfaces of multiple intellectual property (IP) blocks in order to replace traditional links with Chronos Links; performing simplified floorplanning; performing simplified placement; performing simplified clock tree synthesis (CTS) and routing; and performing simplified timing closure." ], [ "1.A system for communicating between intellectual property blocks, the system comprising: a communication channel communicatively coupled between a first intellectual property block and a second intellectual property block for transmission of data between the first and second intellectual property blocks; a slave controller communicatively coupled between the first intellectual property block and the communication channel, the slave controller comprising: a slave synchronizer circuit configured to receive a first asynchronous signal from the communication channel and transform the received first asynchronous signal into a synchronous domain for controlling the transmission of data according to a first protocol of the first intellectual property block, and a slave digital logic circuit configured to create a first control signal and, using digital logic, regulate the transmission of data into the communication channel; and a master controller communicatively coupled between the communication channel and the second intellectual property block, the master controller comprising: a master synchronizer configured to receive a second asynchronous signal from the communication channel and transform the received second asynchronous signal into the synchronous domain for controlling the transmission of data according to a second protocol of the second intellectual property block, and a master digital logic circuit configured to create a second control signal and, using digital logic, regulate the transmission of data out from the communication channel.", "2.The system of claim 1, wherein the communication channel is configured to encode data using delay insensitive coding and transmit data using a quasi-delay insensitive logic circuit and a clock-less temporal compression ratio.", "3.The system of claim 1, wherein the communication channel is configured to translate a traditional handshake communication protocol into a compressed delay insensitive communication protocol where the original control signals are not propagated to the channel but embedded into the data itself.", "4.The system of claim 2, wherein the communication channel is a point-to-point communication channel.", "5.The system of claim 2, wherein the communication channel communicatively couples the first intellectual property block to a plurality of intellectual property blocks comprising the second intellectual property block, wherein the master controller comprises a plurality of master controllers, each master controller communicatively coupled between the communication channel and a different intellectual property block of the plurality of intellectual property blocks.", "6.The system of claim 2, wherein the communication channel communicatively couples the second intellectual property block to a plurality of intellectual property blocks comprising the first intellectual property block, wherein the slave controller comprises a plurality of slave controllers, each slave controller communicatively coupled between the communication channel and a different intellectual property block of the plurality of intellectual property blocks.", "7.The system of claim 2, wherein the communication channel communicatively couples a plurality of first intellectual property blocks to a plurality of second intellectual property blocks, wherein the master controller comprises a plurality of master controllers, each master controller communicatively coupled between the communication channel and a different second intellectual property block of the plurality of second intellectual property blocks, and the slave controller comprises a plurality of slave controllers, each slave controller communicatively coupled between the communication channel and a different first intellectual property block of the plurality of first intellectual property blocks.", "8.The system of claim 1, wherein the delay insensitive coding comprises analog signals.", "9.The system of claim 1, wherein the first intellectual property block is a producer block and the second intellectual property block is a consumer block, wherein data is transmitted from the producer block to the consumer block.", "10.The system of claim 1, wherein the first and second intellectual property blocks are disposed on a common application specific integrated circuit chip.", "11.The system of claim 1, wherein at least one of the slave and the master synchronizer comprises a flip-flop circuit communicatively coupled to the digital logic circuit and configured to transmit the transformed first or second asynchronous signal to the digital logic circuit.", "12.The system of claim 1, wherein at least one of the slave and the master synchronizer comprises a mutex circuit communicatively coupled to a flip-flop circuit, the mutex circuit configured to receive the asynchronous signal and the flip-flop circuit configured to transmit the transformed first or second asynchronous signal to the digital logic circuit.", "13.A system for communicating between intellectual property blocks, the system comprising: a communication channel communicatively coupled between a first intellectual property block and a second intellectual property block for transmission of register information between the first and second intellectual property blocks, the register information comprising data for configuring a mode of operation of the second intellectual property block; a register controller communicatively coupled between the second intellectual property block and the communication channel, the register controller comprising: a synchronizer circuit configured to receive an asynchronous signal from the communication channel and transform the received asynchronous signal into a synchronous domain, and a digital logic circuit configured to create a control signal comprising the data for configuring a mode of operation and transmit the control signal over the communication channel using digital logic.", "14.The system of claim 13, wherein the communication channel is configured to encode data using delay insensitive coding and transmit data using a quasi-delay insensitive logic circuit and a clock-less temporal compression ratio.", "15.The system of claim 13, wherein the communication channel is configured to translate a traditional handshake communication protocol into a compressed delay insensitive communication protocol where the original control signals are not propagated to the channel but embedded into the data itself.", "16.The system of claim 14, wherein the communication channel is a point to point communication channel.", "17.The system of claim 14, wherein the communication channel communicatively couples the first intellectual property block to a plurality of intellectual property blocks comprising the second intellectual property block, wherein the register controller comprises a plurality of register controllers, each register controller communicatively coupled between the communication channel and a different intellectual property block of the plurality of intellectual property blocks.", "18.The system of claim 17, wherein the communication channel communicatively couples a plurality of first intellectual property blocks to the plurality of intellectual property blocks.", "19.The system of claim 14, wherein the communication channel communicatively couples a plurality of intellectual property blocks to the second intellectual property block, the plurality of intellectual property blocks comprising the first intellectual property block.", "20.The system of claim 13, wherein the delay insensitive coding comprises analog signals.", "21.The system of claim 13, wherein the synchronizer comprises a mutex circuit communicatively coupled to a flip-flop circuit, the mutex circuit configured to receive the asynchronous signal and the flip-flop circuit configured to transmit the transformed asynchronous signal to the digital logic circuit.", "22.A system for communicating between intellectual property blocks, the system comprising: a communication channel communicatively coupled between a first intellectual property block and a second intellectual property block for transmission of data between the first and second intellectual property blocks; a controller communicatively coupled to the communication channel, the controller configured to: receive an asynchronous signal from the communication channel, transform the received asynchronous signal into a synchronous domain and control the transmission of data according to a protocol of the second intellectual property block." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>Apparatuses and methods for ASIC interconnect design are provided.", "A Chronos Link is an ASIC on-chip and off-chip interconnect communication protocol that allows two IP blocks to transmit and receive information.", "The Chronos Link protocol may utilize messages or signals to indicate the availability and/or readiness of information to be exchanged between a producer device and a consumer device allowing the communication to be placed on hold and to be resumed seamlessly.", "The Chronos Link stands out by relying on a reduced set of timing assumptions and is robustness against delay variations.", "To do so, the Chronos Link transmits data using delay insensitive (DI) codes and quasi-delay-insensitive (QDI) logic, making the communication insensitive to all wire and gate delay variations.", "Also, a unique characteristic of a Chronos Link, when compared to related solutions, is the fact that the Chronos Link uses temporal compression in its internal paths to reduce the overheads of QDI logic and efficiently transmit data.", "In fact, data can be compressed by different ratios, which can be any rational number (as long as a technology specific maximum frequency restriction is respected).", "Chronos Link protocol agnostic capability allows for direct replacement of many commonly used ASIC communication protocol such as AMBA AXI, CoreConnect, IPBus, OCP, Hyper Transport, Quick Path, etc.", "or it can be tailored to a fully custom implementation.", "Other features and advantages of the present inventive concept should be apparent from the following description which illustrates by way of example aspects of the present inventive concept." ], [ "RELATED APPLICATION INFORMATION This present application is a continuation of U.S. patent application Ser.", "15/344,420, entitled “Application specific integrated circuit link, filed on Nov. 4, 2016, which claims the benefit of priority under 35 U.S.C.", "119(e) to Provisional Patent Application Ser.", "No.", "62/372,221, entitled “Application Specific Integrated Circuit Point-To-Multi-Point Interconnect,” filed Aug. 8, 2016 and claims the benefit of priority under 35 U.S.C.", "119(e) to Provisional Patent Application Ser.", "No.", "62/251,000, entitled “Application Specific Integrated Circuit Point-To-Multi-Point Interconnect,” filed Nov. 4, 2015, and claims the benefit of priority under 35 U.S.C.", "119(e) to Provisional Patent Application Ser.", "No.", "62/372,217, entitled “Application Specific Integrated Circuit Point-to-Point Interconnect,” filed Aug. 8, 2016 and claims the benefit of priority under 35 U.S.C.", "119(e) to Provisional Patent Application Ser.", "No.", "62/250,998, entitled “Application Specific Integrated Circuit Point-to-Point Interconnect,” filed Nov. 4, 2015, all of which are incorporated herein by reference as if set forth in full.", "BACKGROUND 1.Technical Field The various embodiments described herein are related to application specific integrated circuits (ASICs), and more particularly to the design of various ASICs.", "2.Related Art Continuing advances in semiconductor device fabrication technology have yielded a steady decline in the size of process nodes.", "For example, 22 nanometer (nm) process nodes were introduced in 2012 but were quickly succeeded by 14 nm fin field-effect transistors (FinFETs) in 2014 while 5 nm process nodes are projected for 2020.The decrease in process node size allows a growing number of intellectual property (IP) cores or IP blocks to be placed on a single ASIC chip.", "That is, modern ASIC designs often spread numerous process nodes across a comparatively large silicon die, and include combinations of IP blocks and logic functions.", "At the same time, modern technology also requires increased connectivity and large data transfers between various IP blocks.", "In addition, modern ASIC chips frequently include multiple clock domains in order to leverage multi-core implementations.", "Thus, one or more clock signals may need to be distributed across the chip in a manner that minimizes clock skew.", "For instance, the edge of the clock signal received at a logic block located near a clock source should be aligned with those received at more distant logic blocks.", "To simplify data exchange among heterogeneous IPs, data is exchanged using a shared communication protocol (i.e.", "AMBA-AXI) which make use of Master and Slave interfaces.", "Conventionally, a balanced clock signal distribution (i.e., timing closure) is achieved by inserting buffers.", "For example, pursuant to a traditional ASIC design flow, after floor planning and placing various IP blocks, a clock tree (i.e., a clock distribution network) may be synthesized and buffers may be added along the signal path from a clock source to various IP blocks according to the clock tree.", "In fact, timing closure for a clock signal that is distributed over a large and complex ASIC design typically requires the strategic placement of numerous buffers.", "Moreover, the distribution of a clock signal is also highly susceptible to both systematic and random variations.", "In particular, proper timing closure must account for the effects of on-chip variations that arise as a result of different process, voltage, and temperature (PVTs) and operation modes, which would otherwise introduce additional clock skews.", "As such, the most laborious and time consuming aspect of conventional ASIC design tends to be clock alignment.", "Clock tree synthesis and timing closure generally require significant manual intervention.", "In addition, the mechanisms (i.e., buffers) used to balance the clock across an ASIC chip generally consume a majority of the power in any conventional ASIC design.", "If the distance between to IPs is too long for guaranteeing timing closure, one or more Protocol Pipeline Stage (i.e.", "AMBA Register Slice) is inserted between them to relax timing between the two IP ports, complicating even more top level clock routing and balancing, and significantly increasing the used area.", "Therefore, what is needed are an apparatus and method that overcome these significant problems found in the aforementioned conventional approach to modern ASIC design.", "SUMMARY Apparatuses and methods for ASIC interconnect design are provided.", "A Chronos Link is an ASIC on-chip and off-chip interconnect communication protocol that allows two IP blocks to transmit and receive information.", "The Chronos Link protocol may utilize messages or signals to indicate the availability and/or readiness of information to be exchanged between a producer device and a consumer device allowing the communication to be placed on hold and to be resumed seamlessly.", "The Chronos Link stands out by relying on a reduced set of timing assumptions and is robustness against delay variations.", "To do so, the Chronos Link transmits data using delay insensitive (DI) codes and quasi-delay-insensitive (QDI) logic, making the communication insensitive to all wire and gate delay variations.", "Also, a unique characteristic of a Chronos Link, when compared to related solutions, is the fact that the Chronos Link uses temporal compression in its internal paths to reduce the overheads of QDI logic and efficiently transmit data.", "In fact, data can be compressed by different ratios, which can be any rational number (as long as a technology specific maximum frequency restriction is respected).", "Chronos Link protocol agnostic capability allows for direct replacement of many commonly used ASIC communication protocol such as AMBA AXI, CoreConnect, IPBus, OCP, Hyper Transport, Quick Path, etc.", "or it can be tailored to a fully custom implementation.", "Other features and advantages of the present inventive concept should be apparent from the following description which illustrates by way of example aspects of the present inventive concept.", "BRIEF DESCRIPTION OF THE DRAWINGS The above and other aspects and features of the present inventive concept will be more apparent by describing example embodiments with reference to the accompanying drawings, in which: FIG.", "1 is a top level block diagram of a generic ASIC design; FIG.", "2 illustrates a generic Advanced Microcontroller Bus Architecture (AMBA) with Advanced eXtensible Interface (AXI), known as AMBA-AXI, (composed of 5 AMBA-AXI Channels: Address Write (AW), Write (W), Write Response (B), Address Read (AR) and Read (R)); FIG.", "3A details the AMBA AXI Write channel and its control signals; FIG.", "3B illustrates an exemplary implementation of the AMBA AXI Write channel with Chronos Link (a combination of a Chronos Channel plus a Chronos Controller Slave and a Chronos Controller Master) according to various embodiments; FIG.", "4A is a block diagram illustrating an exemplary embodiment of a generic Chronos Channel implementation; FIG.", "4B shows an exemplary Chronos Channel using Join or Merge blocks; FIG.", "4C shows an exemplary Chronos Channel using Fork or Steer blocks; and FIG.", "4D shows an exemplary Chronos Channel using Join, Merge, Fork and Steer blocks.", "FIG.", "5A illustrates an exemplary embodiment of the Chronos Slave Controller; FIG.", "5B illustrates an exemplary embodiment of the Chronos Master Controller; FIG.", "5C illustrate an exemplary embodiment of the Chronos Register Controller; FIG.", "6A illustrates an exemplary implementation of a standard register to register interface; FIG.", "6B illustrates an exemplary implementation of a register interface with Chronos Link (a combination of a Chronos Channel plus a Chronos Register Controller) according to various embodiments; FIG.", "7 illustrates an exemplary embodiment of a Mutex element; FIG.", "8A illustrates an exemplary embodiment of a synchronizer; FIG.", "8B illustrates exemplary Mutex waveforms ; FIG.", "9A illustrates an exemplary embodiment of a Chronos Slave Controller state flow diagram of a burst mode machine; FIG.", "9B illustrates an exemplary embodiment of a Chronos Master Controller state flow diagram of a burst mode machine; FIG.", "10A shows an exemplary embodiment of an AXI producer channel handshake protocol in which two auxiliary signals (ValidM and ReadyM), are used to implement the handshake protocol; FIG.", "10B shows an exemplary embodiment of an AXI consumer channel handshake protocol in which two auxiliary signals (ValidS and ReadyS), are used to implement the handshake protocol; and FIG.", "11 is a block diagram illustrating an exemplary wired or wireless system according to various embodiments.", "DETAILED DESCRIPTION While certain embodiments are described, these embodiments are presented by way of example only, and are not intended to limit the scope of protection.", "The methods and systems described herein may be embodied in a variety of other forms.", "Furthermore, various omissions, substitutions, and changes in the form of the example methods and systems described herein may be made without departing from the scope of protection.", "FIG.", "1 is a chart illustrating an example of top level block diagram 100 for a generic ASIC design.", "The diagram of FIG.", "1 shows data communication between various IP blocks including, for example, but not limited to, Two Central Processing Units (CPU) blocks 151, and 152, a Random Access Memory (RAM) block 153, a Read Only Memory (ROM) block 154, a General Purpose IO (GPIO) block 155, a Universal Asynchronous Receiver-Transmitter (UART) block 156, a Universal Serial Bus (USB) block 157, a Bluetooth block 158, an Ethernet PHY block 159 and an AXI Crossbar block 160; through a specific protocol bus interconnect (i. e. AMBA-AXI interconnect with its 5 communication channels).", "In this diagram each IP has one or more Master or Slave bus interconnect ports to perform the data communication tasks.", "FIG.", "2 shows the detail of a AMBA-AXI interconnect between a Master (block 211) and a Slave (block 212) port.", "In the diagram of FIG.", "2 the five independent channels (Write-Address (AW-CHANNEL in FIG.", "1), Write-Data (W-CHANNEL in FIG.", "1), Write-Response (B-CHANNEL in FIG.", "1), Read-Address (AR-CHANNEL in FIG.", "1), and Read-Data (R-CHANNEL in FIG.", "1)) with their payloads and control signals (e.g., AWREADY and AWVALID, for example as shown in FIG.", "2) can be seen.", "FIG.", "3A illustrates details for one AMBA-AXI channel (Write-Data) where a Master port (310) transfers data to a Slave Port (311).", "FIG.", "3B illustrates an exemplary implementation of a Chronos Link (360) to perform the same data exchange as the AMBA-AXI channel of FIG.", "1 between the Master port (310) and the Slave port (311).", "FIG.", "10A shows an exemplary embodiment of an AXI producer channel handshake protocol in which two auxiliary signals (ValidM and ReadyM), are used to implement the handshake protocol.", "The ValidM signal generated by the producer indicates validity of the data, while the ReadyM signal received by the producer indicates the readiness of the consumer to accept new data.", "Only when both signals are asserted can the data be successfully transferred into the channel.", "In a Chronos-Link, the data is compressed and converted in a delay insensitive code.", "In one embodiment, a Chronos Slave Controller generates the ReadyM signal and transmits it to the producer based on receiving a Full signal from the Chronos Channel.", "FIG.", "10B shows an exemplary embodiment of an AXI consumer channel handshake protocol in which two auxiliary signals (ValidS and ReadyS), are used to implement the handshake protocol.", "The ValidS signal received by the consumer indicates validity of the data, while the ReadyS signal generated by the consumer indicates the readiness of the consumer to accept new data.", "Only when both signals are asserted can the data be successfully extracted from the channel.", "In a Chronos-Link, the data coming from the Chronos Channel is de-compressed and converted back to its original format.", "In one embodiment, a Chronos Master Controller, takes care of generating the ValidS signal and transmitting it to the consumer based on receiving an Empty signal from the Chronos Channel.", "A Chronos Link is an ASIC on-chip and off-chip interconnect communication protocol that allows two IP blocks to transmit and receive information.", "The Chronos Link protocol may utilize messages or signals to indicate the availability and/or readiness of information to be exchanged between a producer device and a consumer device allowing the communication to be placed on hold and to be resumed seamlessly.", "The Chronos Link stands out by relying on a reduced set of timing assumptions and is robustness against delay variations.", "To do so, the Chronos Link transmits data using delay insensitive (DI) codes and quasi-delay-insensitive (QDI) logic, making the communication insensitive to all wire and gate delay variations.", "Also, a unique characteristic of a Chronos Link, when compared to related solutions, is the fact that the Chronos Link uses temporal compression in its internal paths to reduce the overheads of QDI logic and efficiently transmit data.", "In fact, data can be compressed by different ratios, which can be any rational number (as long as a technology specific maximum frequency restriction is respected).", "Chronos Link protocol agnostic capability allows for direct replacement of many commonly used ASIC communication protocol such as AMBA AXI, CoreConnect, IPBus, OCP, Hyper Transport, Quick Path, etc.", "or it can be tailored to a fully custom implementation.", "In one embodiment a Chronos Link (360) is composed of a Chronos Channel (361) fully disclosed in a separate utility patent application (patent application Ser.", "No.", "15/344,416) plus a Chronos Slave Controller (362), communicating directly to the original Master Port 310 and a Chronos Master Controller (363) to connect to the original Slave Port 311.A Chronos Link brings all the advantage of Chronos Channels to a communication protocol, allowing independent clock references for Master and Slave IPs, PVT tolerance, simplified floorplan, enhanced yield, and data time compression (with potential for minimize routing).", "FIG.", "4A is a block diagram illustrating an exemplary embodiment of a generic Chronos Channel 400 according to various embodiments.", "A Chronos Channel is an ASIC Interconnect that allows transmitter blocks to send data to receiver blocks.", "It stands out by relying on a reduced set of timing assumptions and is robust against delay variations.", "To do so, Chronos Channels transmit data using delay insensitive (DI) codes and quasi-delay-insensitive (QDI) logic.", "In this way, Chronos Channels are insensitive to all wire and gate delay variations, but for those belonging to a few specific forking logic paths called isochronic forks.", "Also, a unique characteristic of a Chronos Channel, when compared to related solutions, is the fact that it uses temporal compression in its internal paths to reduce overheads of QDI logic and efficiently transmit data.", "In fact, data can be compressed by different ratios, which can be any rational number (as long as a technology specific maximum frequency restriction is respected).", "In this way, a Chronos Channel is defined by the combination of a DI code (and related handshake protocol), a temporal compression ratio and the hardware required to encode, decode, compress, decompress and transmit data.", "DI codes are a specific family of encoding schemes where no codeword can be contained in another codeword.", "This allows a receiver to perceive the transmission of a codeword unambiguously.", "Such a characteristic eliminates the need for a control signal that identifies the validity of a data channel, and its respective timing assumptions (as in synchronous or bundled-data asynchronous design), as the validity of the data channel is encoded in the data itself.", "Also, note that, usually, DI codes are employed in digital applications, which means that their code words are typically defined using a set of binary values.", "However, in a Chronos Channel, signals do not need to be digital and codewords can be represented using sets with more than 2 values, provided that data is still encoded using a DI code.", "In other words, the data in a Chronos Channel can be composed of analog signals, as long as no codeword is contained in another codeword.", "Such characteristic allows a more flexible usage of Chronos Channels.", "Another aspect of DI codes is that, to allow data transmission, they are usually coupled to a handshake protocol, which is usually 4- or 2-phases.", "Referring to FIG.", "4A, in various embodiments, a Chronos Channel may serve as a connection 400 between a n-bit wide data bus running at a frequency determined by a clockA frequency and a second p-bit wide data bus running at a frequency determined by a clockB frequency.", "According to one exemplary embodiment, the connection 400 may include a transmitter 410 (i.e., a synchronous to asynchronous gasket) and a receiver 420 (i.e., an asynchronous to synchronous gasket).", "In various embodiments, data “n” from a first block (not shown) and a clock signal “clockA” may enter the transmitter 410 and the output (i.e., asynchronous data) from the transmitter 410 may travel through a timing independent channel composed of a “i+1” rows of “h+1”-number of parallel repeaters 430.The asynchronous data from the transmitter 410 is then input into the receiver 420 that is associated with the second block (not shown).", "The output of the receiver 420 includes data “p” that is input into the second block.", "The transmitter 410 also produces an asynchronous signal (labeled “full”) to indicate when the pipeline is full.", "The Receiver 420 also produces an asynchronous signal (labeled “empty”) to indicate when the pipeline is empty.", "Advantageously, the timing independent channel composed of the repeaters 430 is self-regulating and process independent.", "As such, in various embodiments, the timing independent channel between the first block and the second block may be established by a handshake procedure without any need to perform complex timing closure.", "In some embodiments, the timing independent channel between the transmitter 410 and the receiver 420 may include one or more repeaters 430.The repeaters 430 may improve signal strength and throughput in the asynchronous pipeline between the transmitter 410 and the receiver 420.Alternately, the transmitter 410 and the receiver 420 may have a direct connection, i.e., without any repeaters 430.The transmitter 410 also includes “j” encoders (Enc) 411; a “j/i” temporal compressor (TC) 412.The receiver 420 includes a “i/q” temporal decompressor (TD) 422, and “q” decoders (Dec) 421.FIG.", "4B shows a block diagram of an exemplary Chronos Channel using Join or Merge blocks in a multi-point-to-point connection 430 according to various embodiments.", "Referring to FIG.", "4B, in various embodiments, a multi-point-to-point connection 430 may serve as a connection between two producer IP blocks and a third consumer IP block.", "The producer IPs are connected to respective inputs of TXs 431 and 432 (and subsequently to inputs of two repeaters RP0 and RP1 in this example), thereby generating two independent paths in the Chronos Channel.", "These paths can then be combined using a flow control block 433, which can be (but are not limited to) a merge, a join or a select component, depending of the control flow requirements.", "For example, a merge component combines the information of both paths into a single output path, while a select or a join component can arbitrate between paths using some control mechanism.", "The output of the control flow block 433 will be propagated to the inputs of an RX block 434 via a third repeater RP2 in this example.", "Note that repeaters RP0, RP1 and RP2 can be added in any point between TXs 431 and 432 and RX 434, including before and after the flow control block 433.FIG.", "4C shows a block diagram of an exemplary Chronos Channel using Fork or Steer blocks in a point-to-multi-point connection 440 according to various embodiments.", "Referring to FIG.", "4C, in various embodiments, the point-to-multi-point connection 440 may serve as a connection between a producer IP block and two consumer IP blocks.", "The producer IP is connected to an input of TX 441 (and a repeater RP0 in this example) and the generated path in the Chronos Channel can be divided using a flow control block 442, which can be (but is not limited to) a fork or a steer component, depending on the flow control requirements.", "For example, a fork component sends the same input information to both output paths, while a steer component can arbitrate to send different input information to each of the output paths using some control mechanism.", "The outputs of the control flow block 442 are propagated to inputs of RX blocks 443 and 444.Note that repeaters RP0, RP1 and RP2 can be added in any point between the TX 441 and the RXs 443 and 444, including before and after the flow control block 442.FIG.", "4D shows a block diagram of an exemplary Chronos Channel using Join, Merge, Fork and Steer blocks illustrating a multi-point-to-multi-point connection 450 according to various embodiments.", "Referring to FIG.", "4D, in various embodiments, the multi-point-to-multi-point connection 450 may serve as a connection between a set of producer IP blocks and a set of consumer IP blocks.", "Each producer IP block is connected to one of j TXs 451 (TX0, TX1 to TXj), each which generates an independent path in the Chronos Channel.", "These independent paths can then be combined using different combinations of TX-side flow control blocks 452 and any number of repeaters (RP0 to RPh) to implement a specific functionality.", "The combined paths are received at a RX-side set of flow control blocks 453 and forwarded via repeaters (RP0, RP1 to RPq in this example) to q RXs 454 (RX0, RX1 to RXq).", "In the end of each path in the Chronos Channel, the RXs 454 are interfaced with the consumer IPs.", "Note that between the TXs 452 and the RXs 454 (RX0, RX1 to RXq), different combinations of flow control blocks 452 and 453 and repeaters can be employed, to fulfil functional and performance requirements.", "Any of the Chronos Channel connections 400, 420, 430 and 450 may be used as the Chronos Channel 361 described above in reference to FIG.", "3B.", "FIG.", "5A is a block diagram illustrating a Chronos Slave Controller 500 according to various embodiments.", "The Chronos Slave Controller 500 may be used in various embodiments as the Chronos Slave Controller 362 described above in reference to FIG.", "3B.", "The most important element in the controller 500 is the synchronizer 510 which is responsible for the synchronization of the asynchronous signals coming from the Chronos Channel 361 (FIG.", "3B) in asynchronous domain (in particular full) to the synchronous domain.", "Depending on Medium Time Between Failures (MTBF) requirement the physical implementation of the synchronizer can change.", "An exemplary embodiment of the circuit is represented in FIG.", "5A 510 composed of a Mutex (511) followed by a Flip-Flop (512).", "Other embodiments can be implemented such as replacing the Mutex with a second Flip-Flop, or a composition of a “n” number of alternating latches, and or combinations of the above elements, trading latency performance for MTBF performance.", "As can be seen in FIG.", "3B, the addition of the Chronos Slave Controller 500 as the Chronos Slave Controller 362 allows a Master Interface 310 to properly interact with the Chronos Channel 361 as if it was communicating with a standard synchronous Slave Interface.", "FIG.", "5B is a block diagram illustrating a Chronos Master Controller 550 according to various embodiments.", "The Chronos Master Controller 550 may be used in various embodiments as the Chronos Slave Controller 363 described above in reference to FIG.", "3B.", "The most important element in the controller 550 is a synchronizer 560 which is responsible for the synchronization of the asynchronous signals coming from the Chronos Channel 361 in asynchronous domain (in particular empty) to the synchronous domain.", "Depending on Medium Time Between Failures (MTBF) requirement the physical implementation of the synchronizer can change.", "An exemplary embodiment of a synchronizer circuit 560 is represented in FIG.", "5B.", "The synchronizer circuit 560 comprises a Mutex (561) followed by a Flip-Flop (562).", "Other embodiments can be implemented such as replacing the Mutex 561 with a second Flip-Flop 562, or alternatively a “n” number of alternating latches, and or combinations of the above elements, trading latency performance for MTBF performance.", "As can be seen in FIG.", "3B, addition of the Chronos Master Controller 550 as the Chronos Master Controller 363 allows the Slave Interface 311 to properly interact with the Chronos Channel 361 as if it was communicating with a standard synchronous Master Interface.", "FIG.", "7 illustrates an exemplary embodiment of a block diagram of a Mutex (701).", "The Mutex (701) is commonly composed of two main elements: Latch (711) and Metastability Filter (712).", "The Mutex 701 has the characteristics of eliminating metastable levels at its output, or in other words, if either setup-time or hold-time are violated its outputs resolves to a valid logic level; the propagation delay of the outputs can be unbounded when this happens.", "An exemplary implementation of a Mutex is shown in 720.Only one of a G1 and G2 output can reach a “high” logic level at any one time (never both).", "If R1 and R2 inputs transition high in close proximity, metastability can result.", "The metastability filter 712 keeps both outputs (G1 and G2) at a “low” logic level until metastability resolves.", "Table 730 shows an example of a True table of the Mutex 701.FIG.", "8a shows an exemplary implementation of a synchronizer (800) used within a Chronos Master Controller, a Chronos Slave Controller and a Chronos Register Controller.", "It is composed of a Mutex (810), with a pin R2 driven by an inverted version of a clock signal, where the output (mid) of the Mutex (810) is transferred to a Flip-Flop (811).", "The Mutex (810) receiving the inverted clock signal at the R2 pin produces an output (mid) which guarantees at least half a clock cycle of setup time for the Flip-Flop 811.Furthermore, because of the behavior of the Mutex 810, the mid signal presented to the Flip-Flop is always level correct, reducing even further the MTBF of the synchronizer as a whole, compared to the standard 2 Flip-Flop solution.", "FIG.", "8b shows exemplary waveforms (850) of the synchronizer described above.", "FIG.", "9A illustrates an exemplary embodiment of a Chronos Slave Controller state flow diagram of a burst mode machine.", "FIG.", "9A shows a burst mode specification of the behavior of the exemplary Chronos Slave Controller presented in FIG.", "5A.", "As FIG.", "9A shows, at reset, the circuit will set its “ready” output to 1, its “ctrl” output to 0 and enter state S0.At this state, the connected producer IP has no data for the Chronos Channel to consume and the Chronos Channel is not full.", "In this way, at every clock cycle (“clk” at 1), the Chronos Slave Controller can keep its outputs at reset state, to indicate to the producer IP that it is ready to receive data (“ready” at 1) and to signal to the Chronos Channel that it should not consume any data available in its inputs (“ctrl” at 0).", "Note that, at reset, the inputs of the controller are expected to be both 0.Also, note that every transition in the outputs of the controller happen during clock transitions (“clk” at 1) because the IP connected to it is synchronous input (and share the same clock signal of the controller) and the Chronos Channel consumes data from a synchronous bus (the output of the producer IP).", "Therefore, data validity of this bus is signaled by a clocked signal.", "From S0, the circuit will set “ctrl” to 1 and switch to state S1 if a rising edge is detected in its “valid” input, meaning that the producer IP has new data to be consumed.", "At S1, the system is in a state where the producer IP has new data to be consumed and the Chronos Channel is not full.", "Therefore, at every rising edge of the clock signal (“clk” at 1), the controller will write 1 in both its outputs, to indicate to the producer IP that it is ready to receive data (“ready” at 1) and to signal to the Chronos Channel that it should consume the data available in its inputs (“ctrl” at 1).", "From S1, the controller can: (i) go back to S0 if the producer IP signals that it has no new data to be consumed (“valid” switches back to 0); (ii) switch to S2 if the Chronos Channel becomes full (“full” switches to 1); or (iii) stay at S1 if neither of the aforementioned conditions are true (in this case a burst transmission is still taking place).", "At S2, the producer IP has new data to be consumed but the Chronos Channel is full and cannot receive it.", "Therefore, at every clock cycle (“clk” at 1), the controller will set both its outputs to 0, to indicate to the producer IP that it is not ready to receive data (“ready” at 0) and to signal to the Chronos Channel that it should not consume any data available in its inputs (“ctrl” at 0), to avoid overwriting previous data consumed by it.", "From S2, the controller can: (i) go back to S1 if the Chronos Channel frees space for more data (switching “full” back to 0); (ii) switch to S3 if the producer IP signals that it has no new data to be consumed (“valid” switches to 0); or (iii) stay at S2 if neither of the aforementioned conditions are true.", "At S3, the producer IP has no new data and the Chronos Channel is full.", "Hence, at every clock cycle (“clk” at 1), the controller will set both its outputs to 0, to indicate to the producer IP that it is not ready to receive data (“ready” at 0) and to signal to the Chronos Channel that it should not consume any data available in its inputs (“ctrl” at 0), to avoid overwriting previous data consumed by it.", "From S2, the controller can: (i) go back to S2 if the producer IP signals that it has new data to be consumed (“valid” switches back to 1); (ii) switch to S0 if the Chronos Channel frees space for more data (switching “full” to 0); or (iii) stay at S3 if neither of the aforementioned conditions are true.", "FIG.", "9B illustrates an exemplary embodiment of a Chronos Master Controller state flow diagram of a burst mode machine.", "FIG.", "9B shows a burst mode specification of the behavior of the Chronos Master Controller presented in FIG.", "5B.", "As FIG.", "9B shows, at reset, the circuit will set its “valid” output to 0, its “ctrl” output to 1 and enter state S0.At this state, the connected Chronos Channel is empty and there is no data for the consumer IP to consume.", "At every clock cycle (“clk” at 1), the Chronos Slave Controller will keep its valid output at reset state, to indicate to the consumer IP that there is no data for it to consume (“valid” at 0).", "Note that, at reset, the “empty” input of the controller is expected to be at 1 and the “ready” input is expected to be at 0.Also note that every transition in the output of the controller connected to the consumer IP happen during clock transitions because the consumer IP is synchronous (and shares the same clock signal of the controller).", "However, transitions in the output that feed the Chronos Channel are not controlled by the clock signal because the data generated by it is asynchronous.", "From S0, the controller can: (i) switch to S1 if the Chronos Channel has new data to be consumed (“empty” switches to 0); (ii) switch to S3 if the consumer IP becomes ready to receive new data (“ready” switches to 1); or (iii) stay at S0 if neither of the aforementioned conditions are true.", "At S1, the system is in a state where the Chronos Channel has new data to be consumed but the consumer IP cannot receive it.", "Therefore, at every rising edge of the clock signal (“clk” at 1), the controller will write 1 in its “valid” output, to indicate to the consumer IP that new data is available.", "Note that while switching from S0 to S1 or S2 to S1, the controller will switch its “ctrl” output to 0, to signal to the Chronos Channel that the data in its output was not consumed (as “ready” is at 0) and avoid it to be overwritten.", "The value of “ctrl” will stay at 0 until the controller switch to S1.From S1, the controller can: (i) switch to S2 if the consumer IP becomes ready to receive new data (“ready” switches to 1); or (ii) stay at S1.At S2, the system is in a state where the Chronos Channel has new data to be consumed and the consumer IP is ready to receive it.", "Therefore, at every rising edge of the clock signal (“clk” at 1), the controller will write 1 in its “valid” output, to indicate to the consumer IP that new data is available.", "Also, while switching from S2 to S1, the controller will switch its “ctrl” output to 1, to signal to the Chronos Channel that the data in its output will be consumed in the next clock cycle (as “ready” is at 1), so that it can generate new data.", "Note that the value of “ctrl” will stay at 1 until the controller switch to S1.From S2, the controller can: (i) switch back to S1 if the consumer IP stops being ready to receive new data (“ready” switches to 0); (ii) switch to S3 if the Chronos Channel becomes empty and no new data is available for the consumer IP to receive (“empty” switches to 1); or (iii) stay at S2 if neither of the aforementioned conditions are true (in this case a burst is taking place).", "At S3, the system is in a state where the consumer IP is ready to receive data, but the Chronos Channel has no new data in its outputs.", "Therefore, at every rising edge of the clock signal (“clk” at 1), the controller will write 0 in its “valid” output, to indicate to the consumer IP that there is no new data available.", "Note that, while switching from S0 to S3, the controller will switch its “ctrl” output to 1, to signal to the Chronos Channel that its can generate new data in its output as soon as it is ready, because the consumer IP is ready to receive (as “ready” is at 1).", "Note that the value of “ctrl” will stay at 1 until the controller switch to S1.From S3, the controller can: (i) switch back to S2 if the Chronos Channel becomes not empty and has new data for the consumer IP to receive (“empty” switches to 0); (ii) switch to S0 if the consumer IP stops being ready to receive new data (“ready” switches to 0); or (iii) stay at S3 if neither of the aforementioned conditions are true.", "In various embodiments, sets of Chronos Links between different IP blocks allow timing independent channels to be established between IP blocks in the ASIC design 100, for example.", "For example, in reference to FIG.", "1, a first set of five timing independent channel links may be established between the CPU block 151 and the AXI-Crossbar 160 using five different Chronos Links.", "In various embodiments, the first timing independent channel may be a part of a point-to-point connection between the CPU block 151 and the AXI-Crossbar 160 (labeled “intc1” in FIG.", "1).", "Eight other sets of timing independent channel links, each containing five different Chronos Links may be established between the CPU block 152 and the AXI-Crossbar 160 (see “intc2”), the RAM block 153 and the AXI-Crossbar 160 (see “intc3”), the ROM block 154 and the AXI-Crossbar 160 (see “intc4”), the GPIO block 155 and the AXI-Crossbar 160 (see “intc5”), the UART block 156 and the AXI-Crossbar 160 (see “intc6”), the USB block 157 and the AXI-Crossbar 160 (see “intc7”), the Bluetooth block 158 and the AXI-Crossbar 160 (see “intc8”), and the Ethernet PHY block 159 and the AXI-Crossbar 160 (see “intc9”), each using five independent Chronos Links as highlighted for the “intc1” connection for the CPU block 151 in FIG.", "1.According to one exemplary embodiment, timing closure for the ASIC design 100 may be accomplished with simplified, top level checks.", "That is, testing each individual IP block in the ASIC design 100 across all corners (i.e., PVT corners) obviates any complex timing margin evaluation for the ASIC design 100 as a whole.", "As illustrated in FIG.", "3B, introduction of a Chronos Link 360 (Chronos Channel 361+Chronos Slave Controller 362+Chronos Master Controller 363) has the unique characteristic to completely decouple the Master Interface 211 (FIG.", "2) from the Slave Interface 212 (FIG.", "2) in terms of both frequency and phase of operation as well as data bus width.", "The combination of a timing insensitive channel (e.g., a Chronos Channel) and proper handling of the communication protocol (i.e.", "AMBA-AXI) allows for isochronous, mesochronous, plesiochronous and asynchronous communication between the IP blocks without data corruption and/or data losses.", "Furthermore, the availability of linear compression within the Chronos Channel enables the possibility of connecting IP blocks even with different data width (as long as they operate on the same protocol).", "Chronos link 360 includes linear compression capability that allows for easier routing in the ASIC design 100 between IP blocks by lowering the total numbers of wires connecting the different IP blocks.", "As a result of lowering the total number of wires, manufacturing wire failure yield is also improved.", "Power efficiency is also boosted by allowing the various IP blocks to send and receive short bursts of data independently from each other (Master Interface can potentially send a quick burst of data and power down, while the Slave Interface on the other side is still in power down state) due to the intrinsic memory characteristic of the Chronos Channel, and the handling of the communication protocol by the Chronos slave and master controllers 362 and 363.FIG.", "6A illustrates an exemplary implementation of a standard register to register interface 600 commonly used in ASIC design to dynamically change IP configuration settings for different modes of operation.", "The register configuration usually does not require a complete handshake.", "The register interface 600 includes a transmit register 610 linked to a receive register 620 via a channel.", "FIG.", "6B illustrates an exemplary implementation of a register interface 650 with Chronos Link (a combination of a Chronos Channel plus a Chronos Register Controller) according to various embodiments.", "FIG.", "6B shows an implementation of a Chronos Link (651) to perform the same configuration register exchange between the TX Register (610) and the RX Register (620).", "In one embodiment a Chronos Link (651) composed of a Chronos Channel (361) fully disclosed in a separate utility patent (Attorney Docket Number 123666-001UT1) plus a Chronos Register Controller (652).", "A Chronos Link links the transmit register 610 and the receive register 620 and brings all the advantages of Chronos Channels to a communication protocol, allowing independent clock references for Master and Slave IP blocks, PVT tolerance, simplified floorplan, enhanced yield, data time compression (with potential for minimize routing).", "FIG.", "5C is a block diagram illustrating a Chronos Register Controller 570 according to various embodiments.", "The most important element in the controller is the synchronizer 560 which is responsible for the synchronization of the asynchronous signals coming from the TX register 610 via Chronos Channel 361 in the asynchronous domain (in particular empty) and being transformed to the synchronous domain of the RX register 620.Depending on Medium Time Between Failures (MTBF) requirement the physical implementation of the synchronizer 560 can change.", "An exemplary embodiment of the circuit is represented in FIG.", "5C 570 composed of a Mutex (561) followed by a Flip-Flop (562).", "Other embodiments can be implemented such as replacing the Mutex with a second Flip-Flop, or a composition of a “n” number of alternating latches, and or a combinations of the above elements, trading latency performance for MTBF performance.", "FIG.", "11 is a block diagram illustrating a wired or wireless system 750 according to various embodiments that may utilize the systems and various types of links and channels described above in reference to the other Figures.", "In various embodiments, the system 750 may be a conventional personal computer, computer server, personal digital assistant, smart phone, tablet computer, or any other processor enabled device that is capable of wired or wireless data communication.", "A person having ordinary skill in the art can appreciate that other computer systems and/or architectures may be used without departing from the scope of the present inventive concept.", "The system 750 preferably includes one or more processors, such as processor 760.Additional processors may be provided, such as an auxiliary processor to manage input/output, an auxiliary processor to perform floating point mathematical operations, a special-purpose microprocessor having an architecture suitable for fast execution of signal processing algorithms (e.g., digital signal processor), a slave processor subordinate to the main processing system (e.g., back-end processor), an additional microprocessor or controller for dual or multiple processor systems, or a coprocessor.", "Such auxiliary processors may be discrete processors or may be integrated with the processor 760.The processor 760 is preferably connected to a communication bus 755.The communication bus 755 may include a data channel for facilitating information transfer between storage and other peripheral components of the system 750.The communication bus 755 further may provide a set of signals used for communication with the processor 760, including a data bus, address bus, and control bus (not shown).", "The communication bus 755 may comprise any standard or non-standard bus architecture such as, for example, bus architectures compliant with industry standard architecture (“ISA”), extended industry standard architecture (“EISA”), Micro Channel Architecture (“MCA”), peripheral component interconnect (“PCI”) local bus, or standards promulgated by the Institute of Electrical and Electronics Engineers (“IEEE”) including IEEE 488 general-purpose interface bus (“GPIB”), IEEE 696/S-100, and the like.", "The system 750 preferably includes a main memory 765 and may also include a secondary memory 770.The main memory 765 provides storage of instructions and data for programs executing on the processor 760.The main memory 765 is typically semiconductor-based memory such as dynamic random access memory (“DRAM”) and/or static random access memory (“SRAM”).", "Other semiconductor-based memory types include, for example, synchronous dynamic random access memory (“SDRAM”), Rambus dynamic random access memory (“RDRAM”), ferroelectric random access memory (“FRAM”), and the like, including read only memory (“ROM”).", "The secondary memory 770 may optionally include an internal memory 775 and/or a removable medium 780, for example a floppy disk drive, a magnetic tape drive, a compact disc (“CD”) drive, a digital versatile disc (“DVD”) drive, etc.", "The removable medium 780 is read from and/or written to in a well-known manner.", "Removable medium 780 may be, for example, a floppy disk, magnetic tape, CD, DVD, SD card, etc.", "The removable medium 780 is a non-transitory computer readable medium having stored thereon computer executable code (i.e., software) and/or data.", "The computer software or data stored on the removable medium 780 is read into the system 750 for execution by the processor 760.In alternative embodiments, secondary memory 770 may include other similar means for allowing computer programs or other data or instructions to be loaded into the system 750.Such means may include, for example, an external medium 795 and a communication interface 790.Examples of external medium 795 may include an external hard disk drive or an external optical drive, or and external magneto-optical drive.", "Other examples of secondary memory 770 may include semiconductor-based memory such as programmable read-only memory (“PROM”), erasable programmable read-only memory (“EPROM”), electrically erasable read-only memory (“EEPROM”), or flash memory (block oriented memory similar to EEPROM).", "Also included are a removable medium 580 and a communication interface 790, which allow software and data to be transferred from an external medium 795 to the system 750.The system 750 may also include an input/output (“I/O”) interface 785.The I/O interface 785 facilitates input from and output to external devices.", "For example the I/O interface 785 may receive input from a keyboard or mouse and may provide output to a display.", "The I/O interface 785 is capable of facilitating input from and output to various alternative types of human interface and machine interface devices alike.", "The communication interface 790 allows software and data to be transferred between system 750 and external devices (e.g.", "printers), networks, or information sources.", "For example, computer software or executable code may be transferred to system 750 from a network server via communication interface 790.Examples of communication interface 790 include, for example, but not limited to, a modem, a network interface card (“NIC”), a wireless data card, a communications port, a PCMCIA slot and card, an infrared interface, and an IEEE 1394 fire-wire.", "The communication interface 790 preferably implements industry promulgated protocol standards, such as Ethernet IEEE 802 standards, Fiber Channel, digital subscriber line (“DSL”), asynchronous digital subscriber line (“ADSL”), frame relay, asynchronous transfer mode (“ATM”), integrated digital services network (“ISDN”), personal communications services (“PCS”), transmission control protocol/Internet protocol (“TCP/IP”), serial line Internet protocol/point to point protocol (“SLIP/PPP”), and so on, but may also implement customized or non-standard interface protocols as well.", "Software and data transferred via the communication interface 790 are generally in the form of electrical communication signals 605.In one exemplary embodiment, these electrical communication signals 605 are provided to the communication interface 790 via a communication channel 635.In one embodiment, the communication channel 635 may be a wired or wireless network, or any variety of other communication links.", "The communication channel 635 carries the electrical communication signals 605 and can be implemented using a variety of wired or wireless communication means including wire or cable, fiber optics, conventional phone line, cellular phone link, wireless data communication link, radio frequency (“RF”) link, or infrared link, just to name a few.", "Computer executable code (i.e., computer programs or software) is stored in the main memory 765 and/or the secondary memory 770.Computer programs can also be received via communication interface 590 and stored in the main memory 765 and/or the secondary memory 770.Such computer programs, when executed, enable the system 550 to perform the various functions of the present invention as previously described.", "In this description, the term “computer readable medium” is used to refer to any non-transitory computer readable storage media used to provide computer executable code (e.g., software and computer programs) to the system 750.Examples of these media include the main memory 765, the secondary memory 770 (including the internal memory 775, the removable medium 780, and the external medium 795), and any peripheral device communicatively coupled with the communication interface 790 (including a network information server or other network device).", "These non-transitory computer readable mediums are means for providing executable code, programming instructions, and software to the system 750.In one embodiment implemented using software, the software may be stored on a computer readable medium and loaded into the system 750 by way of the removable medium 780, the I/O interface 785, or the communication interface 790.In such an embodiment, the software is loaded into the system 750 in the form of electrical communication signals 605.The software, when executed by the processor 760, preferably causes the processor 760 to perform the inventive features and functions previously described herein.", "The system 750 also includes optional wireless communication components that facilitate wireless communication over a voice and over a data network.", "The wireless communication components comprise an antenna system 655, a radio system 645 and a baseband system 625.In the system 750, radio frequency (“RF”) signals are transmitted and received over the air by the antenna system 655 under the management of the radio system 645.In one embodiment, the antenna system 655 may comprise one or more antennae and one or more multiplexors (not shown) that perform a switching function to provide the antenna system 655 with transmit and receive signal paths.", "In the receive path, received RF signals can be coupled from a multiplexor to a low noise amplifier (not shown) that amplifies the received RF signal and sends the amplified signal to the radio system 645.In alternative embodiments, the radio system 645 may comprise one or more radios that are configured to communicate over various frequencies.", "In one embodiment, the radio system 645 may combine a demodulator (not shown) and modulator (not shown) in one integrated circuit (“IC”).", "The demodulator and modulator can also be separate components.", "In the incoming path, the demodulator strips away the RF carrier signal leaving a baseband receive audio signal, which is sent from the radio system 645 to the baseband system 625.If the received signal contains audio information, then baseband system 625 decodes the signal and converts it to an analog signal.", "Then the signal is amplified and sent to a speaker.", "The baseband system 625may also also receive analog audio signals from a microphone.", "These analog audio signals are converted to digital signals and encoded by the baseband system 625.The baseband system 625 also codes the digital signals for transmission and generates a baseband transmit audio signal that is routed to the modulator portion of the radio system 645.The modulator mixes the baseband transmit audio signal with an RF carrier signal generating an RF transmit signal that is routed to the antenna system 655 and may pass through a power amplifier (not shown).", "The power amplifier amplifies the RF transmit signal and routes it to the antenna system 655 where the signal is switched to the antenna port for transmission.", "The baseband system 625 may also be communicatively coupled with the processor 760.The processor 760 has access to main memory 765 and/or secondary memory 770.The processor 760 is preferably configured to execute instructions (i.e., computer programs or software) that can be stored in the main memory 765 or the secondary memory 770.Computer programs can also be received from the baseband system 625 and stored in the main memory 765 or in secondary memory 770, or executed upon receipt.", "Such computer programs, when executed, enable the system 750 to perform the various functions of the present invention as previously described.", "For example, the main memory 765 may include various software modules (not shown) that are executable by processor 760.The accompanying claims and their equivalents are intended to cover such forms or modifications as would fall within the scope and spirit of the protection.", "For example, the example apparatuses, methods, and systems disclosed herein can be applied wireless communication devices incorporating HF and/or UHF RFID reader capabilities.", "The various components illustrated in the figures may be implemented as, for example, but not limited to, software and/or firmware on a processor, ASIC/FPGA/DSP, or dedicated hardware.", "Also, the features and attributes of the specific example embodiments disclosed above may be combined in different ways to form additional embodiments, all of which fall within the scope of the present disclosure.", "The foregoing method descriptions and the process flow diagrams are provided merely as illustrative examples and are not intended to require or imply that the steps of the various embodiments must be performed in the order presented.", "As will be appreciated by one of skill in the art the order of steps in the foregoing embodiments may be performed in any order.", "Words such as “thereafter,” “then,” “next,” etc.", "are not intended to limit the order of the steps; these words are simply used to guide the reader through the description of the methods.", "Further, any reference to claim elements in the singular, for example, using the articles “a,” “an” or “the” is not to be construed as limiting the element to the singular.", "The various illustrative logical blocks, modules, circuits, and algorithm steps described in connection with the embodiments disclosed herein may be implemented as electronic hardware, computer software, or combinations of both.", "To clearly illustrate this interchangeability of hardware and software, various illustrative components, blocks, modules, circuits, and steps have been described above generally in terms of their functionality.", "Whether such functionality is implemented as hardware or software depends upon the particular application and design constraints imposed on the overall system.", "Skilled artisans may implement the described functionality in varying ways for each particular application, but such implementation decisions should not be interpreted as causing a departure from the scope of the present invention.", "The hardware used to implement the various illustrative logics, logical blocks, modules, and circuits described in connection with the aspects disclosed herein may be implemented or performed with a general purpose processor, a digital signal processor (DSP), an application specific integrated circuit (ASIC), a field programmable gate array (FPGA) or other programmable logic device, discrete gate or transistor logic, discrete hardware components, or any combination thereof designed to perform the functions described herein.", "A general-purpose processor may be a microprocessor, but, in the alternative, the processor may be any conventional processor, controller, microcontroller, or state machine.", "A processor may also be implemented as a combination of receiver devices, e.g., a combination of a DSP and a microprocessor, a plurality of microprocessors, one or more microprocessors in conjunction with a DSP core, or any other such configuration.", "Alternatively, some steps or methods may be performed by circuitry that is specific to a given function.", "In one or more exemplary aspects, the functions described may be implemented in hardware, software, firmware, or any combination thereof.", "If implemented in software, the functions may be stored as one or more instructions or code on a non-transitory computer-readable storage medium or non-transitory processor-readable storage medium.", "The steps of a method or algorithm disclosed herein may be embodied in processor-executable instructions that may reside on a non-transitory computer-readable or processor-readable storage medium.", "Non-transitory computer-readable or processor-readable storage media may be any storage media that may be accessed by a computer or a processor.", "By way of example but not limitation, such non-transitory computer-readable or processor-readable storage media may include RAM, ROM, EEPROM, FLASH memory, CD-ROM or other optical disk storage, magnetic disk storage or other magnetic storage devices, or any other medium that may be used to store desired program code in the form of instructions or data structures and that may be accessed by a computer.", "Disk and disc, as used herein, includes compact disc (CD), laser disc, optical disc, digital versatile disc (DVD), floppy disk, and Blu-ray disc where disks usually reproduce data magnetically, while discs reproduce data optically with lasers.", "Combinations of the above are also included within the scope of non-transitory computer-readable and processor-readable media.", "Additionally, the operations of a method or algorithm may reside as one or any combination or set of codes and/or instructions on a non-transitory processor-readable storage medium and/or computer-readable storage medium, which may be incorporated into a computer program product.", "Although the present disclosure provides certain example embodiments and applications, other embodiments that are apparent to those of ordinary skill in the art, including embodiments which do not provide all of the features and advantages set forth herein, are also within the scope of this disclosure.", "Accordingly, the scope of the present disclosure is intended to be defined only by reference to the appended claims." ] ]
Patent_15876059
[ [ "MAGNETIC SHIELD STRUCTURE", "A magnetic shield structure includes a housing made of a dielectric material, and a magnetic shield body formed by metal plating.", "The magnetic shield body is partially provided on at least one of an outer surface and an inner surface that form a surface of the housing made of the dielectric material." ], [ "1.A magnetic shield structure, comprising: a housing made of a dielectric material; and a magnetic shield body formed by metal plating, wherein the magnetic shield body is partially provided on at least one of an outer surface and an inner surface that form a surface of the housing made of the dielectric material.", "2.The magnetic shield structure according to claim 1, wherein the magnetic shield body is formed by the metal plating in a region facing high-frequency transmission path disposed in the housing on the inner surface and/or the outer surface of the housing, such that a characteristic impedance of the high-frequency transmission path becomes uniform.", "3.The magnetic shield structure according to claim 1, wherein the magnetic shield body is formed by the metal plating and a dielectric in a region facing the high-frequency transmission path disposed in the housing on the inner surface and/or the outer surface of the housing, such that a characteristic impedance of the high-frequency transmission path becomes uniform.", "4.The magnetic shield structure according to claim 1, wherein the housing is made up of a base and a case fitted to the base.", "5.The magnetic shield structure according to claim 4, wherein the magnetic shield body is formed on at least a part of an outer surface of the case.", "6.The magnetic shield structure according to claim 4, wherein the magnetic shield body is formed on at least a part of an inner surface of the case.", "7.The magnetic shield structure according to claim 4, wherein the magnetic shield body formed on the outer surface of the case and the magnetic shield body formed on the inner surface of the case are electrically connected by the metal plating.", "8.The magnetic shield structure according to claim 4, wherein the magnetic shield body is formed on at least a part of a bottom surface of the base.", "9.The magnetic shield structure according to claim 4, wherein the magnetic shield body formed on the outer surface of the case and the magnetic shield body formed on the bottom surface of the base are electrically connected by the metal plating.", "10.The magnetic shield structure according to claim 1, wherein the housing is made up of a plug body and a socket body connected to the plug body.", "11.The magnetic shield structure according to claim 10, wherein the magnetic shield body is formed by the metal plating on at least a part of the plug body.", "12.The magnetic shield structure according to claim 10, wherein the magnetic shield body is formed by the metal plating on at least a part of the socket body.", "13.An electric/electronic component comprising: a magnetic shield structure, comprising: a housing made of a dielectric material; and a magnetic shield body formed by metal plating, wherein the magnetic shield body is partially provided on at least one of an outer surface and an inner surface that form a surface of the housing.", "14.The magnetic shield structure according to claim 2, wherein the magnetic shield body is formed by the metal plating and a dielectric in a region facing the high-frequency transmission path disposed in the housing on the inner surface and/or the outer surface of the housing, such that a characteristic impedance of the high-frequency transmission path becomes uniform.", "15.The magnetic shield structure according to claim 2, wherein the housing is made up of a base and a case fitted to the base.", "16.The magnetic shield structure according to claim 3, wherein the housing is made up of a base and a case fitted to the base.", "17.The magnetic shield structure according to claim 5, wherein the magnetic shield body is formed on at least a part of an inner surface of the case.", "18.The magnetic shield structure according to claim 5, wherein the magnetic shield body formed on the outer surface of the case and the magnetic shield body formed on the inner surface of the case are electrically connected by the metal plating.", "19.The magnetic shield structure according to claim 6, wherein the magnetic shield body formed on the outer surface of the case and the magnetic shield body formed on the inner surface of the case are electrically connected by the metal plating.", "20.The magnetic shield structure according to claim 5, wherein the magnetic shield body is formed on at least a part of a bottom surface of the base." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>However, the high-frequency relay is made up by covering, with the metal case, the relay body formed by covering a body with a cover.", "Hence the high-frequency relay requires the separate metal case, the number of parts and the number of assembling steps are large, and the productivity is low.", "Further, external dimensions of the metal case and the positional relationship between the metal case and a high-frequency transmission component affect high-frequency characteristics.", "For this reason, high dimensional accuracy and assembly accuracy are required in manufacturing and assembling the metal case, and the manufacturing and the assembly are thus not easy.", "The metal case covers the entire exposed surface, except for the installation surface, of the relay body.", "This leads to a problem in which desired high-frequency characteristics cannot be obtained due to the metal case covering an unnecessary region and a region that causes deterioration in characteristics of a transmission path structure.", "In view of the above problems, an object of the present invention is to provide a magnetic shield structure having high productivity and excellent high-frequency characteristics, and easy to manufacture and assembly.", "For solving the above problem, a magnetic shield structure according to the present invention is partially provided with a magnetic shield body, formed by metal plating, on at least one of an outer surface and an inner surface that form the surface of a housing made of a dielectric material.", "According to the present invention, since the magnetic shield body is provided directly on the housing, it is possible to obtain a magnetic shield structure having high productivity with smaller numbers of parts and assembling steps.", "Also, a magnetic shield body is formed directly in a region that requires the housing.", "Hence it is possible to prevent deterioration in high-frequency characteristics based on the variations of the dimensional accuracy and the assembly accuracy in the housing.", "Then, a magnetic shield body is formed only in a region that requires the housing.", "Therefore, as in the conventional example, the magnetic shield body is not formed in an unnecessary region or a region that causes deterioration in characteristics of a transmission path structure.", "As a result, the effect of obtaining a magnetic shield structure with excellent high-frequency characteristics is provided." ], [ "BACKGROUND Technical Field The present invention relates to a magnetic shield structure, and particularly a magnetic shield structure formed by performing metal plating on a housing.", "Related Art As an example of a magnetic shield structure, there has been a high-frequency relay that is magnetically shielded by fitting a separate metal case to a relay body and covering the entire relay body (Patent Document 1).", "Patent Document 1: Japanese Unexamined Patent Publication No.", "2000-340084 SUMMARY However, the high-frequency relay is made up by covering, with the metal case, the relay body formed by covering a body with a cover.", "Hence the high-frequency relay requires the separate metal case, the number of parts and the number of assembling steps are large, and the productivity is low.", "Further, external dimensions of the metal case and the positional relationship between the metal case and a high-frequency transmission component affect high-frequency characteristics.", "For this reason, high dimensional accuracy and assembly accuracy are required in manufacturing and assembling the metal case, and the manufacturing and the assembly are thus not easy.", "The metal case covers the entire exposed surface, except for the installation surface, of the relay body.", "This leads to a problem in which desired high-frequency characteristics cannot be obtained due to the metal case covering an unnecessary region and a region that causes deterioration in characteristics of a transmission path structure.", "In view of the above problems, an object of the present invention is to provide a magnetic shield structure having high productivity and excellent high-frequency characteristics, and easy to manufacture and assembly.", "For solving the above problem, a magnetic shield structure according to the present invention is partially provided with a magnetic shield body, formed by metal plating, on at least one of an outer surface and an inner surface that form the surface of a housing made of a dielectric material.", "According to the present invention, since the magnetic shield body is provided directly on the housing, it is possible to obtain a magnetic shield structure having high productivity with smaller numbers of parts and assembling steps.", "Also, a magnetic shield body is formed directly in a region that requires the housing.", "Hence it is possible to prevent deterioration in high-frequency characteristics based on the variations of the dimensional accuracy and the assembly accuracy in the housing.", "Then, a magnetic shield body is formed only in a region that requires the housing.", "Therefore, as in the conventional example, the magnetic shield body is not formed in an unnecessary region or a region that causes deterioration in characteristics of a transmission path structure.", "As a result, the effect of obtaining a magnetic shield structure with excellent high-frequency characteristics is provided.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a perspective view illustrating an electromagnetic relay of a first embodiment, to which a magnetic shield structure according to the present invention has been applied.", "FIG.", "2 is a perspective view illustrating a state where a case has been removed from the electromagnetic relay illustrated in FIG.", "1.FIG.", "3 is a front sectional view of the electromagnetic relay illustrated in FIG.", "1.FIG.", "4 is a central front sectional view of the electromagnetic relay illustrated in FIG.", "1.FIG.", "5 is a side sectional view of the electromagnetic relay illustrated in FIG.", "1.FIG.", "6 is a partially enlarged sectional view of the electromagnetic relay illustrated in FIG.", "1.FIG.", "7 is a perspective view of only a magnetic shield body illustrated in FIG.", "1.FIG.", "8 is a graph illustrating analysis results of Example and Comparative Example according to the first embodiment.", "FIG.", "9 is a perspective view of a case illustrating a second embodiment of a magnetic shield structure according to the present invention.", "FIG.", "10 is a perspective view of only a magnetic shield body provided in the case illustrated in FIG.", "9.FIG.", "11 is a perspective view of only the magnetic shield body located on an inner side in FIG.", "10.FIG.", "12 is a perspective view of the case illustrated in FIG.", "9 viewed from different viewpoints.", "FIG.", "13 is a perspective view of only the magnetic shield body illustrated in FIG.", "10 viewed from different angles.", "FIG.", "14 is a partially enlarged sectional view of the case illustrated in FIG.", "9.FIG.", "15 is a partially enlarged sectional view of only the magnetic shield body of the case illustrated in FIG.", "14.FIG.", "16 is a perspective view illustrating a switch according to a third embodiment, to which a magnetic shield structure according to the present invention has been applied.", "FIG.", "17 is a perspective view of the switch illustrated in FIG.", "16, viewed from a different viewpoint.", "FIG.", "18 is a central front sectional view of the switch illustrated in FIG.", "16.FIG.", "19 is a perspective view illustrating a state where a case has been removed from the switch illustrated in FIG.", "16.FIG.", "20 is a perspective view illustrating a state where an operation lever is removed from FIG.", "19.FIG.", "21 is a perspective view illustrating a state where a base is removed from FIG.", "20.FIG.", "22 is a sectional perspective view of only a magnetic shield body illustrated in FIG.", "16.FIG.", "23 is an exploded perspective view illustrating a connector according to a fourth embodiment, to which a magnetic shield structure according to the present invention has been applied.", "FIG.", "24 is a sectional exploded perspective view of the connector illustrated in FIG.", "23.FIG.", "25 is a perspective view illustrating a state where a resin molded portion is removed from the connector illustrated in FIG.", "24.FIG.", "26 is a perspective view of only a magnetic shield body illustrated in FIG.", "25 viewed from a different angle.", "DETAILED DESCRIPTION A magnetic shield structure according to an aspect of the present invention is partially provided with a magnetic shield body, formed by metal plating, on at least one of an outer surface and an inner surface that form a surface of a housing made of a dielectric material.", "According to this aspect, since the magnetic shield body is provided directly on the housing, it is possible to obtain a magnetic shield structure having high productivity with smaller numbers of parts and assembling steps.", "Also, a magnetic shield body is formed directly in a region that requires the housing.", "Hence it is possible to prevent deterioration in high-frequency characteristics based on the variations of the dimensional accuracy and the assembly accuracy in the housing.", "Then, a magnetic shield body is formed only in a region that requires the housing.", "Therefore, as in the conventional example, the magnetic shield body is not formed in an unnecessary region or a region that causes deterioration in characteristics of a transmission path structure.", "As a result, the effect of obtaining a magnetic shield structure with excellent high-frequency characteristics is provided.", "In the magnetic shield structure according to the aspect of the present invention, the magnetic shield body may be formed by the metal plating in a region facing high-frequency transmission path disposed in the housing on the inner surface and/or the outer surface of the housing, such that a characteristic impedance of the high-frequency transmission path becomes uniform.", "According to this aspect, it is unnecessary to always provide the magnetic shield body by metal plating on the entire inner surface and/or outer surface of the housing.", "Hence it is possible to save a raw material and obtain a magnetic shield structure with high productivity.", "In a magnetic shield structure according to another aspect of the present invention, the magnetic shield body may be formed by the metal plating and a dielectric in a region facing the high-frequency transmission path disposed in the housing on the inner surface and/or the outer surface of the housing, such that a characteristic impedance of the high-frequency transmission path becomes uniform.", "According to this aspect, it is unnecessary to always provide the magnetic shield body by metal plating and a dielectric on the entire inner surface and/or outer surface of the housing.", "Hence it is possible to save a raw material and obtain a magnetic shield structure with high productivity.", "In a magnetic shield structure according to another aspect of the present invention, the housing may be made up of a base and a case fitted to the base.", "According to this aspect, a highly versatile magnetic shield structure can be obtained.", "In a magnetic shield structure according to a new aspect of the present invention, the magnetic shield body may be formed on at least a part of an outer surface of the case Further, the magnetic shield body may be formed on at least a part of the inner surface of the case.", "According to this aspect, since the magnetic shield body can be formed in a necessary region as necessary, it is possible to obtain a magnetic shield structure having more excellent high-frequency characteristics.", "In a magnetic shield structure according to another aspect of the present invention, the magnetic shield body formed on the outer surface of the case and the magnetic shield body formed on the inner surface of the case may be electrically connected by the metal plating.", "According to this aspect, it is possible to obtain a magnetic shield structure having more excellent high-frequency characteristics.", "In a magnetic shield structure according to another aspect of the present invention, the magnetic shield body may be provided on at least a part of a bottom surface of the base.", "According to this aspect, since the magnetic shield body can be formed in a necessary region as necessary, a magnetic shield structure having a wide application can be obtained.", "In a magnetic shield structure according to a new aspect of the present invention, the magnetic shield body formed on the outer surface of the case and the magnetic shield body formed on the bottom surface of the base may be electrically connected by the metal plating.", "According to this aspect, it is possible to connect to the ground via the magnetic shield body provided on the bottom surface of the base.", "In a magnetic shield structure according to another aspect of the present invention, the housing may be made up of a plug body and a socket body connected to the plug body.", "According to this aspect, a highly versatile magnetic shield structure can be obtained.", "In a magnetic shield structure according to another aspect of the present invention, the magnetic shield body may be formed by the metal plating on at least a part of the plug body.", "In addition, the magnetic shield body may be formed by the metal plating on at least a part of the socket body.", "According to this aspect, there is an effect that a magnetic shield structure can be formed in a necessary region as necessary.", "An electric/electronic component according to an aspect of the present invention includes the above magnetic shield structure.", "According to this aspect, the magnetic shield structure is not limited to electromagnetic relays, switches, and connectors, and can be applied to other electric devices and electronic components having a high-frequency transmission component in a housing made of resin.", "Embodiments of a magnetic shield structure according to the present invention will be described with reference to FIGS.", "1 to 25.First Embodiment In a first embodiment, as illustrated in FIGS.", "1 to 7, a magnetic shield structure according to the present invention has been applied to a magnetically shielded self-holding type electromagnetic relay 10.As illustrated in FIGS.", "1 and 2, the electromagnetic relay 10 rotatably supports a movable block 30 in an internal space formed by fitting a case 40 to a base 11.For convenience of description, a magnetic shield body 50 provided in the case 40 is illustrated in a dotted pattern.", "As illustrated in FIGS.", "2 to 6, the base 11 is formed by integrally molding an electromagnet block 20.Further, as illustrated in FIG.", "2, fixed contacts 12, 14 are disposed at corner portions of the upper surface of the base 11.The fixed contacts 12, 14 are connected to fixed contact terminals 13, 15 integrally molded with the base 11, respectively.", "Further, the base 11 is provided with common connection receivers 16 on opposite side edges of the upper surface of the base 11.The common connection receiver 16 is connected to a common terminal 17 integrally molded with the base 11.Note that a coil terminal 18 integrally molded with the base 11 is connected to a coil 22 of the electromagnet block 20 described later.", "As illustrated in FIGS.", "3 and 5, the electromagnet block 20 is formed by winding a coil 22 about an iron core 21 having a gate shape in cross section via an insulating sheet (not shown), to integrally mold the iron core 21 and the coil 22 with a spool 23.Magnetic pole portions 21a, 21b of the iron core 21 are exposed from both side edges of the upper surface of the base 11 (FIG.", "4).", "As illustrated in FIG.", "4, the movable block 30 is formed by disposing a permanent magnet 32 having a plate shape on the lower surface of a movable iron piece 31 having a strip shape and disposing movable touch pieces 33, 33 in parallel on both sides of the movable iron piece 31 as illustrated in FIG.", "2, to integrally mold the permanent magnet 32 and the movable touch pieces 33, 33.As illustrated in FIGS.", "2 and 5, the movable touch piece 33 extends laterally from the side edge thereof, and has a connecting tongue piece 34 having a substantially planar T-shape.", "As illustrated in FIG.", "2, the connecting tongue pieces 34 protrude on the same axial center from both side end surfaces of the movable block 30.Further, as illustrated in FIG.", "3, both ends of the movable touch piece 33 have a twin contact structure in which movable contacts 35, 36 are provided on the respective divided pieces divided into two areas in the width direction.", "Then, as illustrated in FIG.", "5, by welding and integrating the connecting tongue piece 34 of the movable block 30 to the common connection receiver 16 of the base 11, the movable block 30 is rotatably supported.", "As a result, both ends 31a, 31b of the movable iron piece 31 face the magnetic pole portions 21a, 21b of the iron core 21 so as to be contactable with and separable from each other alternately.", "Further, the movable contacts 35, 36 of the movable touch piece 33 face the fixed contacts 12, 14 alternately so as to be contactable and separable.", "The case 40 is a resin molded product having a box shape that can be fitted to the base 11.The magnetic shield body 50 is formed on the outer peripheral surface of the case 40 by a molded interconnect devices (MID) molding method.", "In the MID molding method, laser irradiation is performed on a molded article formed from a material in which a resin and a conductive material are mixed, based on a predetermined pattern, and the resin is removed.", "Then, metal plating is performed on the exposed conductive material so as to form a desired circuit pattern.", "A tubular magnetic shield portion 51 is also provided on the entire surface of a terminal portion 41 extending from the opening edge of the case 40 (FIG.", "7).", "This is for connecting to a ground of a printed circuit board (not shown) or the like.", "The magnetic shield body 50 is provided based on the knowledge that high-frequency signals tend to leak if the characteristic impedance varies in the high-frequency transmission path.", "Therefore, in order to reduce the leakage of the high-frequency signal, the magnetic shield body 50 is formed so as to reduce variations in the characteristic impedance in the high-frequency transmission path.", "In short, instead of forming the magnetic shield body by metal plating over the entire outer peripheral surface of the case 40, a suitable magnetic shield body 50 is formed in a necessary region.", "As a result, the magnetic shield body 50 constitutes, for example, a microstrip structure, a strip line structure, and a coplanar line structure.", "The region where the magnetic shield body 50 is formed may be a region facing the high-frequency transmission path installed in the housing among the inner surface and/or the outer surface of a housing formed of a base and a case.", "More specifically, it is preferable to arrange and form metal plating and/or dielectric so that the characteristic impedance of the high-frequency transmission path becomes uniform.", "It is a matter of course that air is also considered as a dielectric.", "For example, it is preferable to arrange and form the metal plating and/or the dielectric so that the characteristic impedance in each region of the high-frequency transmission path is equal to the reference value of 50 Ω.", "This is because if there is a difference in characteristic impedance for each region of the high-frequency transmission path, high frequency leaks easily from the boundary of the region where the difference is present, and the high-frequency characteristics are degraded.", "As the microstrip structure in this embodiment, for example, as illustrated in FIG.", "6, a common terminal 17 which is a high-frequency transmission path is sandwiched between a spool 23 made of resin of an electromagnet block 20 which is a dielectric and a case 40 made of resin which is a dielectric material provided with a magnetic shield body 50.Further, as a strip line structure, for example, as illustrated in FIG.", "6, a structure in which a case 40 made of resin which is a dielectric provided with a magnetic shield body 50 is disposed above a movable touch piece 33 which is a high-frequency transmission path can be mentioned.", "As a coplanar line structure, for example, as illustrated in FIG.", "1, between a coil terminal 18 which is a high-frequency transmission path and a magnetic shield body 50 formed on the outer peripheral surface of a case 40 made of resin which is a dielectric, a structure in which a minute gap portion is formed can be mentioned.", "Similarly, the fixed contact terminals 13, 15 and the common terminal 17 constitute a coplanar line structure.", "Next, a method of operating a self-holding type electromagnetic relay having the above-described configuration will be described.", "For example, when no voltage is applied to the coil 22 of the electromagnet block 20 illustrated in FIG.", "4, one end 31a of the movable iron piece 31 is attracted to one magnetic pole portion of the iron core 21, for example, the magnetic pole portion 21a, thereby constituting a magnetic circuit.", "Therefore, the movable contact 35 of the movable touch piece 33 illustrated in FIG.", "3 comes into contact with the fixed contact 12, and the movable contact 36 is separated from the fixed contact 14.When a voltage is applied to the coil 22 so as to generate a magnetic line of force in a direction canceling the magnetic lines of force of the permanent magnet 32 illustrated in FIG.", "4, the other end 31b of the movable iron piece 31 illustrated in FIG.", "3 is attracted to the magnetic pole portion 21b of the iron core 21 against the magnetic force of the permanent magnet 32.Hence the movable block 30 rotates about the connecting tongue piece 34 (FIG.", "5).", "As a result, after the movable contact 36 of the movable touch piece 33 illustrated in FIG.", "3 comes into contact with the fixed contact 14, the other end 31b of the movable iron piece 31 illustrated in FIG.", "4 is attracted to the magnetic pole portion 21b of the iron core 21 to form a magnetic circuit.", "Subsequently, even when the application of the voltage to the coil 22 is stopped, the movable block 30 keeps its state by the magnetic force of the permanent magnet 32.Finally, a voltage in a direction opposite to the above-mentioned voltage application direction is applied to the coil 22 illustrated in FIG.", "4.As a result, when the generated magnetic lines of force overcome the magnetic lines of force of the permanent magnet 32, one end 31a of the movable iron piece 31 illustrated in FIG.", "4 is attracted to the magnetic pole portion 21a of the iron core 21, and the movable block 30 rotates about the connecting tongue piece 34 (FIG.", "5).", "For this reason, after the movable contact 35 provided at one end of the movable touch piece 33 illustrated in FIG.", "3 comes into contact with the fixed contact 12, one end 31a of the movable iron piece 31 illustrated in FIG.", "4 is attracted to the magnetic pole portion 21a of the iron core 21.Thereafter, the contacts are switched by repeating the same operation.", "EXAMPLE The high-frequency characteristics of the electromagnetic relay provided with the magnetic shield body 50 according to the embodiment were analyzed.", "The analysis result is illustrated in the graph of FIG.", "8.COMPARATIVE EXAMPLE As a comparative example, there was used a case where a metal case covering the entire case was covered without forming a magnetic shield body of metal plating on the case of the same electromagnetic relay as in the first embodiment.", "The other high-frequency characteristics were analyzed on the same conditions as in the first embodiment described above.", "The analysis result is illustrated in the graph of FIG.", "8.The high-frequency characteristics are measured by time domain reflectometry (TDR) method in FIG.", "8.The TDR method refers to a method of applying a high-speed pulse or a step signal input to an object to be measured and measuring a returned reflection waveform.", "From the reflection waveform, a characteristic impedance in the course of the high-frequency transmission path can be detected.", "In FIG.", "8, “(A) Terminal portion” indicates a characteristic impedance of only a distal region of the common terminal 17 in FIG.", "2 which is surface-mounted on a printed circuit board.", "“(B) Fixed contact terminal” indicates a characteristic impedance in a region from a boundary of the distal region to the common connection receiver 16 in the common terminal 17.“(C) Movable touch piece” indicates a characteristic impedance in a region from the base of the connecting tongue piece 34 of the movable touch piece 33 to the movable contact 36.“(D) Fixed contact terminal” indicates a characteristic impedance in a region from the fixed contact 14 of the fixed contact terminal 15 provided on the fixed contact terminal 15 to a boundary of a distal region surface-mounted on the printed circuit board.", "“(E) Terminal portion” indicates a characteristic impedance of only a distal region of the fixed contact terminal 15 which is surface-mounted on the printed circuit board.", "As is apparent from FIG.", "8, it was found that the reflection waveform of the example is closer to the characteristic impedance (50 0) than the reflection waveform of the comparative example.", "As a result, it was found that the variation in the characteristic impedance in the example is smaller, and the leakage of the high frequency signal is smaller, than in the comparative example.", "Second Embodiment In a second embodiment, as illustrated in FIGS.", "9 to 15, a magnetic shield structure according to the present invention has been applied to the case 40 of the electromagnetic relay as in the first embodiment.", "A difference from the first embodiment is that a magnetic shield body 60 is also formed on the inner peripheral surface of the case 40 by the MID molding method.", "Therefore, the difference from the first embodiment will be described, and the same parts will be denoted by the same reference numerals and the description thereof will be omitted.", "The magnetic shield body 60 is provided at each corner portion facing the inner peripheral surface of the case 40.In particular, as illustrated in FIG.", "11, the magnetic shield body 60 has a pair of arms 61 extending from both ends.", "The arm 61 has a shape that surrounds both ends of the movable touch piece 33 of the first embodiment.", "Further, the magnetic shield body 60 is electrically connected to the tubular magnetic shield portion 51 of the magnetic shield body 50 via a leg 62 extending downward.", "According to the embodiment, as illustrated in FIGS.", "14 and 15, both ends of the movable touch piece 33 are disposed so as to form a minute gap between the magnetic shield body 60 attached to the inner surface of a case made of resin which is a dielectric and its arm 61.As a result, a coplanar line structure similar to that of the first embodiment is constituted.", "Therefore, according to the second embodiment, not only the magnetic shield body 50 but also the magnetic shield body 60 is provided, whereby the characteristic impedance can be easily adjusted.", "For this reason, the variation in the characteristic impedance in the high-frequency transmission path is more easily reduced, and the high-frequency characteristics can be improved.", "There is thus an advantage that the degree of design freedom is widened to further expand the application.", "Third Embodiment In a third embodiment, as illustrated in FIGS.", "16 to 22, a magnetic shield structure according to the present invention has been applied to a switch 70.The switch 70 is formed of a plate-shaped base 71, a box-shaped case 80, and an operation lever 100 assembled to the box-shaped case 80.As illustrated in FIG.", "18, the plate-shaped base 71 is integrally molded with a pair of fixed contact terminals 72, 73 so that fixed contacts 74, 75 are exposed at both side edges of the upper surface.", "Further, the plate-shaped base 71 has four positioning legs 76 projecting from the lower surface thereof between the fixed contact terminals 72, 73.In the plate-shaped base 71, a magnetic shield body 90 is formed on the lower surface including the positioning legs 76 by the MID molding method.", "The box-shaped case 80 has a box shape capable of covering the upper surface of the plate-shaped base 71, and an operation hole 81 is formed on the ceiling surface.", "In addition, the box-shaped case 80 has a magnetic shield body 91 having an annular shape and formed on its outer surface by the MID molding method.", "The magnetic shield body 91 is electrically connected to the magnetic shield body 90 via a connecting portion 92.Therefore, the magnetic shield body 91 can be connected to the ground via the magnetic shield body 90 covering the positioning legs 76 of the plate-shaped base 71.As illustrated in FIG.", "18, the operation lever 100 has an inverted T-shape in cross section, and a caulking projection 101 provided on the lower surface thereof is inserted and fixed into a caulking hole 108 of a movable touch piece 105.The movable touch piece 105 has a cross-sectional shape in which movable contacts 106, 107 located at both ends of the movable touch piece 105 are in contact with the fixed contacts 74, 75, respectively.", "The operation lever 100 protrudes from the operation hole 81 of the box-shaped case 80 so that an operation protrusion 102 protruding from the upper surface of the operation lever 100 is operable.", "Therefore, by sliding the operation protrusion 102 of the operation lever 100, the movable contacts 106, 107 come into contact with the fixed contacts 74, 75, respectively.", "Even when a high frequency signal flows to the fixed contact terminal 72, the movable touch piece 105 and the fixed contact terminal 73, it is magnetically shielded by the magnetic shield bodies 90, 91.There is thus an advantage that not only leakage of high frequency signals but also entry of external signals can be prevented.", "Fourth Embodiment In a fourth embodiment, as illustrated in FIGS.", "22 to 25, a magnetic shield structure according to the present invention has been applied to a high-frequency connector.", "The high-frequency connector includes a plug 110 and a socket 130.The plug 110 is formed by integrally molding three connecting pins 112, 113, 114 disposed side by side into a plug body 111 formed of resin serving as a dielectric.", "A magnetic shield body 120 is formed on the plug body 111 by the MID molding method.", "That is, in the magnetic shield body 120, an upper piece portion 121 and a lower piece portion 122 which are disposed so as to sandwich the connecting pins 112, 113, 114 from above and below, are electrically connected by a connecting portion 123.The connecting portion 123 is electrically connected to the connecting pin 114 connected to the ground.", "Further, the socket 130 is formed by integrally molding three receiving pins 132, 133, 134 disposed side by side into a socket body 131 formed of resin serving as a dielectric.", "In the socket body 131, a magnetic shield body 140 is formed by the MID molding method.", "That is, in the magnetic shield body 140, an upper piece portion 141 and a lower piece portion 142 which are formed so as to sandwich the receiving pins 132, 133, 134 from above and below, are electrically connected by a connecting portion 143.The connecting portion 143 is electrically connected to the receiving pin 134 connected to the ground.", "A magnetic shield structure according to the present invention is not limited to the electromagnetic relay, the switch, and the connector described above, and may be applied to other electric devices and electronic components having a high-frequency transmission component in a housing made of resin.", "Description of Symbols 10 electromagnetic relay 11 base 12 fixed contact 13 fixed contact terminal 14 fixed contact 15 fixed contact terminal 16 common connection receiver 17 common terminal 18 coil terminal 20 electromagnet block 21 iron core 22 coil 23 spool 30 movable block 31 movable iron piece 32 permanent magnet 33 movable touch piece 40 case 41 terminal portion 50 magnetic shield body 51 tubular magnetic shield portion 60 magnetic shield body 61 arm 62 leg 70 switch 71 plate-shaped base 72 fixed contact terminal 73 fixed contact terminal 74 fixed contact 75 fixed contact 76 positioning leg 80 box-shaped case 81 operation hole 90 magnetic shield body 91 magnetic shield body 92 connecting portion 110 plug 111 plug body 120 magnetic shield body 121 upper piece portion 122 lower piece portion 123 connecting portion 130 socket 131 socket body 140 magnetic shield body 141 upper piece portion 142 lower piece portion 143 connecting portion" ] ]
Patent_15876069
[ [ "ELECTROMAGNETIC DEVICE AND ELECTROMAGNETIC RELAY USING SAME", "An electromagnetic device includes a spool having a cylindrical body with a through hole, a secondary coil formed in a spiral shape along an outer peripheral surface of the cylindrical body and formed with a closed circuit by metal plating, and a primary coil formed of a conductive wire wound around the secondary coil via an insulating material covering the secondary coil.", "An induced current, generated by applying a voltage to any one of the primary coil and the secondary coil, is allowed to flow to the other coil different from the one coil." ], [ "1.An electromagnetic device comprising: a spool having a cylindrical body with a through hole; a secondary coil formed in a spiral shape along an outer peripheral surface of the cylindrical body and formed with a closed circuit by metal plating; and a primary coil formed of a conductive wire wound around the secondary coil via an insulating material covering the secondary coil, wherein an induced current, generated by applying a voltage to any one of the primary coil and the secondary coil, is allowed to flow to the other coil different from the one coil.", "2.The electromagnetic device according to claim 1, wherein a guard portion is provided at at least one end of the cylindrical body, and wherein both ends of the secondary coil, formed on the outer peripheral surface of the cylindrical body, are electrically connected to each other by a lead wire formed by metal plating through a communication hole provided in the cylindrical body and the guard portion and an inner peripheral surface of the through hole in the cylindrical body.", "3.The electromagnetic device according to claim 2, further comprising: an operation indicator lamp fixed to the guard portion and electrically connected to the secondary coil.", "4.The electromagnetic device according to claim 3, wherein the operation indicator lamp is a light-emitting diode.", "5.An electromagnetic relay comprising: a base; and an electromagnetic device incorporated into the base, and comprising: a spool having a cylindrical body with a through hole; a secondary coil formed in a spiral shape along an outer peripheral surface of the cylindrical body and formed with a closed circuit by metal plating; and a primary coil formed of a conductive wire wound around the secondary coil via an insulating material covering the secondary coil, wherein an induced current, generated by applying a voltage to any one of the primary coil and the secondary coil, is allowed to flow to the other coil different from the one coil.", "6.The electromagnetic relay according to claim 5, wherein a movable iron piece is disposed so as to be attracted by magnetic force to a magnetic pole portion of an iron core protruding from the guard portion provided at at least one end of the cylindrical body among iron cores inserted through the through holes of the spool, the magnetic force being generated by applying a voltage to any one of the primary coil and the secondary coil, and wherein the movable iron piece is provided with a notch through which light of the operation indicator lamp is transmitted.", "7.The electromagnetic relay according to claim 6, further comprising: an operation check window configured to transmit the light of the operation indicator lamp on an outer peripheral surface of a casing fitted to the base.", "8.The electromagnetic relay according to claim 7, wherein the operation check window is a transparent window provided in the casing." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>However, the coil 112 is wound in two layers on the bobbin 113 , so that the bobbin complete body 111 becomes bulky and the device cannot be made more compact in size.", "In the bobbin complete body 111 , it is necessary to wind extended wires 112 a , 112 a ′ of the coil 112 around external connection terminals 114 a , 114 a ′.", "Similarly, it is necessary to wind extended wires 112 b , 112 b ′ of the coil 112 around external connection terminals 114 b , 114 b ′.", "For this reason, with the bobbin complete body 111 , it takes time and effort to do connection work on the coil 112 and the productivity is thus low.", "One or more embodiments of the present invention provides an electromagnetic device compact in size and with high productivity and an electromagnetic relay using the electromagnetic device.", "An electromagnetic device according to one or more embodiments of the present invention is provided with: a spool having a cylindrical body with a through hole; a secondary coil formed in a spiral shape along an outer peripheral surface of the cylindrical body and formed with a closed circuit by metal plating; and a primary coil formed of a conductive wire wound around the secondary coil via an insulating material covering the secondary coil.", "An induced current, generated by applying a voltage to any one of the primary coil and the secondary coil, is allowed to flow to the other coil different from the one coil.", "According to one or more embodiments of the present invention, with the secondary coil formed by metal plating, an electromagnetic device more compact in size and smaller in bulk than that of the conventional example can be obtained.", "Further, according to the above aspect of the present invention, there is no need to bind the extended wire of the coil to the coil terminal as in the conventional example, thus facilitating the connection work, so that an electromagnetic device with high productivity can be obtained." ], [ "BACKGROUND Technical Field The present invention relates to an electromagnetic device, particularly an electromagnetic device incorporated into an electromagnetic relay by winding a coil twice, and an electromagnetic relay using this electromagnetic device.", "Related Art As an electromagnetic device with a double-wound coil, for example, a bobbin complete body 111 has been used which is formed by winding a coil 112 in two layers around a bobbin 113, as illustrated in FIG.", "8 of Patent Document 1.In FIG.", "8, an electromagnetic relay in which the bobbin complete body 111 is incorporated into a base 116 is disclosed.", "Patent Document 1: Japanese Unexamined Patent Publication No.", "H3-254035 SUMMARY However, the coil 112 is wound in two layers on the bobbin 113, so that the bobbin complete body 111 becomes bulky and the device cannot be made more compact in size.", "In the bobbin complete body 111, it is necessary to wind extended wires 112a, 112a′ of the coil 112 around external connection terminals 114a, 114a′.", "Similarly, it is necessary to wind extended wires 112b, 112b′ of the coil 112 around external connection terminals 114b, 114b′.", "For this reason, with the bobbin complete body 111, it takes time and effort to do connection work on the coil 112 and the productivity is thus low.", "One or more embodiments of the present invention provides an electromagnetic device compact in size and with high productivity and an electromagnetic relay using the electromagnetic device.", "An electromagnetic device according to one or more embodiments of the present invention is provided with: a spool having a cylindrical body with a through hole; a secondary coil formed in a spiral shape along an outer peripheral surface of the cylindrical body and formed with a closed circuit by metal plating; and a primary coil formed of a conductive wire wound around the secondary coil via an insulating material covering the secondary coil.", "An induced current, generated by applying a voltage to any one of the primary coil and the secondary coil, is allowed to flow to the other coil different from the one coil.", "According to one or more embodiments of the present invention, with the secondary coil formed by metal plating, an electromagnetic device more compact in size and smaller in bulk than that of the conventional example can be obtained.", "Further, according to the above aspect of the present invention, there is no need to bind the extended wire of the coil to the coil terminal as in the conventional example, thus facilitating the connection work, so that an electromagnetic device with high productivity can be obtained.", "BRIEF DESCRIPTION OF THE DRAWINGS Embodiments the present invention will become apparent from the following description in conjunction with embodiments with reference to the accompanying drawings.", "In the drawings, FIG.", "1 is a perspective view illustrating an electromagnetic relay into which an electromagnetic device according to an embodiment of the present invention has been incorporated; FIG.", "2 is an exploded perspective view of the electromagnetic relay into which the electromagnetic device according to the embodiment of the present invention has been incorporated; FIG.", "3 is a perspective view illustrating a state where the base has been erased from FIG.", "1; FIG.", "4 is a perspective view illustrating a state where a primary coil has been erased from FIG.", "3; FIG.", "5 is a perspective view illustrating a spool illustrated in FIG.", "4; FIG.", "6A is a longitudinal sectional perspective view of FIG.", "5; FIG.", "6B is a partially enlarged perspective view of FIG.", "6A; FIG.", "7A is a transverse sectional perspective view of FIG.", "5 as viewed from another viewpoint; FIG.", "7B is a partially enlarged perspective view of FIG.", "7A; and FIG.", "8 is a perspective view of an electromagnetic device of Patent Document 1.DETAILED DESCRIPTION Before continuing with the description of the present invention, the same reference numerals are provided to the same parts in the accompanying drawings.", "In describing embodiments of the present invention and in describing configurations represented in the drawings, terms indicating directions such as “up”, “down”, “left”, and “right”, and other terms including those, will be used.", "The purpose for using those terms is to facilitate understanding of the embodiments through the drawings.", "Accordingly, those terms do not necessarily indicate directions used at the time of actually using the embodiments of the present invention.", "A technical scope recited in the claims shall not be restrictively interpreted by using those terms.", "A description will be given of a case where an electromagnetic device according to the embodiment of the present invention is incorporated into an electromagnetic relay according to the accompanying drawings of FIGS.", "1 to 7B.", "As illustrated in FIG.", "2, an electromagnetic relay 10 includes a base 11, an electromagnetic device 20 installed on the base 11, a movable iron piece 40 that rotates based on excitation and demagnetization of the electromagnetic device 20, a contact mechanism 50 mounted on the base 11, a card 60 that drives the contact mechanism 50 via the movable iron piece 40, and a casing 70.For convenience of explanation, the casing 70 (see FIG.", "2) is not illustrated in FIG.", "1.As illustrated in FIGS.", "1 and 2, the base 11 is provided with a placement space 12 for installing the electromagnetic device 20 on one side of an upper surface of the base 11.Three terminal holes (not illustrated) are provided on the other side of the upper surface of the base 11 to form the contact mechanism 50.In the placement space 12, terminal holes (not illustrated) for press-fitting coil terminals 27, 27 of the electromagnetic device 20 are provided at adjacent corner portions on the front side of the placement space 12 in FIG.", "2.Further, the placement space 12 is provided with a rib 13 having a flat gate shape at the rear-side corner portion in FIG.", "2.The rib 13 is provided with a press-fit groove 14 for press-fitting a yoke 32, which will be described later, into the corner portion of the inner side surface thereof.", "The rib 13 has, on its facing outer side surfaces, engaging claw portions 15 for fixing a casing 70, which will be described later, onto the rib 13.As illustrated in FIG.", "2, the electromagnetic device 20 includes a spool 21, a primary coil 30, an iron core 31, and the yoke 32.As illustrated in FIG.", "5, the spool 21 is formed of a cylindrical body 22 and guard portions 24, 25 formed integrally at both axial ends of the cylindrical body 22.As illustrated in FIGS.", "6A and 6B, the cylindrical body 22 is provided with a through hole 23 in which the iron core 31 having a T-shaped cross section can be inserted from the upper opening to prevent it from coming off.", "Further, as illustrated in FIGS.", "5 to 7B, a secondary coil 26 formed along the outer peripheral surface of the cylindrical body 22 is formed by the molded interconnect device (MID) molding method, for example.", "The MID molding method is a method in which a molded article made of a material obtained by mixing a resin and a conductive material is irradiated with a laser in a predetermined pattern to remove the resin and then metal plating is performed on the exposed conductive material, thereby forming a desired circuit pattern.", "In the embodiment, as illustrated in FIGS.", "5, 7A and 7B, patterns 26a are formed at predetermined pitches in the secondary coil 26, the patterns 26a extending in a circumferential direction along the outer peripheral surface of the cylindrical body 22 and being axially parallel to each other.", "Then, the patterns 26a, which are adjacent to each other vertically, are connected by a stepped auxiliary pattern 26b (FIG.", "7A).", "Further, as illustrated in FIG.", "7B, the lower end of the secondary coil 26 is connected to a lead wire 26c (FIG.", "6A) along the substantially axial direction on the inner peripheral surface of the through hole 23 of the cylindrical body 22 through a communication hole 22a provided in the cylindrical body 22, the lead wire 26c having been formed by metal plating by the MID molding method, for example.", "The lead wire 26c is connected to a lead wire 26d provided on the upper surface of the guard portion 24 by metal plating by the MID molding method, for example.", "The lead wire 26d is connected to a lead wire 26e (FIG.", "7A) formed by metal plating on the rear surface of the guard portion 24 through a communication hole 24a (FIG.", "6B) provided in the guard portion 24.The lead wire 26e is connected to the upper end of the secondary coil 26.Therefore, the secondary coil 26 forms a closed circuit.", "Note that a light emitting element 33 and a resistor 34 are connected in series to the lead wire 26d formed in the guard portion 24 (FIG.", "6A).", "The light emitting element 33 functions as an example of an operation indicator lamp, and as a specific example, it is a light-emitting diode (LED).", "In the embodiment, the light emitting element 33 and the resistor 34 are directly connected to the lead wire 26d of the guard portion 24.There is thus an advantage that the number of parts and assembling steps in the assembling process are small, the productivity is high, and the electromagnetic device 20 which is space-saving can be obtained.", "Further, as illustrated in FIG.", "6A, the spool 21 is provided with a recess 25a for fitting the yoke 32, which will be described later, to the guard portion 25.In addition, as illustrated in FIG.", "5, the coil terminals 27, 27 are press-fitted into terminal holes 25b, 25b provided on the side end face of the guard portion 25 (FIG.", "4).", "An insulating film 30a is wound around the cylindrical body 22 of the spool 21 as an example of an insulating material, and a conductive wire 30b is wound around the insulating film 30a to form the primary coil 30, thus constituting the primary coil 30.A extended wire from the conductive wire 30b of the primary coil 30 is then soldered by being bound to binding portions 27a, 27a of the coil terminals 27, 27 (FIG.", "3).", "In the embodiment, ribs 28, 28 capable of press-fitting connection terminals (not illustrated) are formed on the guard portion 24 of the spool 21.This is because the spool 21 is used for assembling other electromagnetic relays.", "The yoke 32 is a magnetic material having an L-shaped cross section, and as illustrated in FIG.", "2, a support portion 32a is formed by cutting out the upper end thereof.", "Further, the yoke 32 has a caulking hole 32c in a horizontal portion 32b of the yoke 32.Then, an iron core body of the iron core 31 is inserted into the through hole 23 of the cylindrical body 22 of the spool 21 around which the primary coil 30 is wound.", "A one end 31a, connected to one end of the iron core body and protruding like a guard from one end of the cylindrical body 22, is fixed, for example by caulking, to the caulking hole 32c of the yoke 32.Meanwhile, the other end, connected to the other end of the iron core body and protruding like a guard from the other end of the cylindrical body 22, is taken as a magnetic pole portion 31b.", "Therefore, the iron core 31 is a magnetic material (FIG.", "2) having a T-shaped cross section made up of the iron core body with the one end 31a and the magnetic pole portion 31b, and the iron core body of the iron core 31 has a cross-sectional area capable of being inserted through the through hole 23 of the cylindrical body 22 of the spool 21.As illustrated in FIG.", "2, the movable iron piece 40 is formed of a magnetic material bent into a substantially L-shaped cross section.", "The movable iron piece 40 is rotatably supported around the support portion 32a of the yoke 32 via a hinge spring 35 fixed to the rear surface of the yoke 32, for example by caulking.", "As a result, the movable iron piece 40 has a horizontal portion (plate portion) 41 which faces so as to be able to contact and separate from the magnetic pole portion 31b of the iron core 31.In the movable iron piece 40, the horizontal portion 41 is provided with a notch 42 for visually checking the light emitting element 33.In other words, the notch 42 is configured to transmit the light, emitted by the light emitting element 33, to the outside.", "As illustrated in FIG.", "3, the contact mechanism 50 includes a fixed contact terminal 51 to which a normally closed fixed contact 51a is fixed, for example by caulking, a movable touch piece 52 to which a movable contact 52a is fixed, for example by caulking, and a fixed contact terminal 53 to which a normally open fixed contact 53a is fixed, for example by caulking As illustrated in FIG.", "1, a terminal portion 51b of the fixed contact terminal 51, a terminal portion 52b of the movable touch piece 52, and a terminal portion 53b of the fixed contact terminal 53 are press-fitted into the base 11, to form the contact mechanism 50.As a result, the movable contact 52a faces the normally closed fixed contact 51a and the normally open fixed contact 53a so as to be able to contact and separate from each other.", "As illustrated in FIGS.", "1 to 4, the card 60 has a recess (not illustrated) engaging with a lower end 43 of the movable iron piece 40 on one side of the facing front and rear surfaces, while the card 60 has an operating protrusion 61 projecting from the other side thereof.", "Then, the card 60 engages the recess with the lower end 43 of the movable iron piece 40 assembled to the yoke 32.As a result, the operating protrusion 61 is pressure-welded to the movable touch piece 52 through a through hole 51c of the fixed contact terminal 51.The casing 70 has a box shape that can be fitted to the base 11, and an engagement hole 71 is provided in the lower side edge of each of the facing side surfaces.", "The ceiling surface of the casing 70 is provided with an operation check window 72 through which the light emitting element 33 can be checked visually.", "An example of the operation check window 72 is a transparent window.", "That is, the operation check window 72 is disposed to face the notch 42, and is configured so as to guide the light, emitted by the light emitting element 33, to the outside through the notch 42 and the operation check window 72.Next, the operation of the electromagnetic relay 10 will be described.", "First, when no voltage is applied to the primary coil 30 of the electromagnetic device 20, as illustrated in FIG.", "1, no induced current is generated in the secondary coil 26, and the light emitting element 33 is not lit.", "Further, the movable touch piece 52 biases the lower end 43 of the movable iron piece 40 via the card 60.The movable contact 52a is thus in contact with the normally closed fixed contact 51a.", "The horizontal portion 41 of the movable iron piece 40 is separated from the magnetic pole portion 31b of the iron core 31.When a voltage is applied to the primary coil 30 for excitation, the magnetic line of force passing through the iron core 31 attracts the horizontal portion 41 of the movable iron piece 40 to the magnetic pole portion 31b of the iron core 31.Then, against the spring force of the movable touch piece 52, the movable iron piece 40 rotates around the support portion 32a of the yoke 32, and the lower end 43 of the movable iron piece 40 presses the card 60.Therefore, the operating protrusion 61 of the card 60 presses the movable touch piece 52, and the movable touch piece 52 rotates.", "As a result, the movable contact 52a is separated from the normally closed fixed contact 51a, and thereafter comes into contact with the normally open fixed contact 53a.", "Then, the horizontal portion 41 of the movable iron piece 40 is attracted to the magnetic pole portion 31b of the iron core 31.When a voltage is applied to the primary coil 30, an induced current flows through the secondary coil 26 by electromagnetic induction, and the light emitting element 33 is lit via the lead wire 26d and the like.", "The light of the light emitting element 33 is then transmitted through the notch 42 of the movable iron piece 40 provided above the light emitting element 33 and the operation check window 72, and whether or not the light emitting element 33 is lit can be checked from the operation check window 72 of the casing 70.Hence in the embodiment, the light emitting element 33 continues to emit light while a voltage is applied to the primary coil 30, so that whether or not the electromagnetic relay 10 is in operation can be determined from the outside of the electromagnetic relay 10.Note that at least a part of the casing 70 may have the operation check window 72 which is translucent or transparent so that the light of the light emitting element 33 can be visually checked from the outside.", "Subsequently, when the application of the voltage to the primary coil 30 is stopped, the magnetic line of force passing through the iron core 31 disappears, and the movable touch piece 52 pushes back the movable iron piece 40 via the card 60.Thus, after being separated from the normally open fixed contact 53a, the movable contact 52a comes into contact with the normally closed fixed contact 51a and returns to its original position.", "Then, the induced current flowing through the secondary coil 26 disappears, and the light emitting element 33 is turned off.", "This enables visual checking that the electromagnetic relay 10 has stopped operating.", "According to the embodiment, with the secondary coil 26 formed by metal plating, it is possible to obtain the electromagnetic device 20 more compact in size and smaller in bulk than that of the conventional example.", "Further, according to the embodiment, there is no need to bind the extended wire of the coil to the coil terminal as in the conventional example, thus facilitating the connection work, so that the electromagnetic device 20 with high productivity can be obtained.", "In the embodiment, the light emitting element 33 is directly attached to the guard portion 24 of the spool 21.Therefore, it is unnecessary to attach the light emitting element 33 to the guard portion 24 of the spool 21 via the connection terminal.", "Furthermore, there is no need to electrically connect the light emitting element 33 to the connection terminal via a lead wire.", "This eliminates the need to do assembling work and soldering work on the connection terminal, and the electromagnetic device with high productivity can be obtained with small numbers of parts and assembling steps.", "Further, the secondary coil 26 is formed in advance on the cylindrical body 22 of the spool 21 by metal plating, for example, the MID molding method, thus eliminating the need to do winding work on the secondary coil 26, so that the productivity is further improved.", "Moreover, the light emitting element 33 is lit by an induced current flowing through the secondary coil 26.This eliminates the need to obtain the power, which is necessary for lighting the light emitting element 33, from an external power supply.", "As a result, it is unnecessary to connect the light emitting element 33 to the external power supply, and an electromagnetic device 20 having a simple structure can be obtained.", "Although the secondary coil 26 of the electromagnetic device 20 according to the embodiment is provided with the stepped auxiliary pattern 26b in a part of the secondary coil 26, a smoothly continuous spiral secondary coil may be formed.", "Further, the communication holes 22a, 24a of the spool 21 may be formed in a mortar shape in order to facilitate laser irradiation performed in the MID molding method.", "A variety of embodiments of the present invention have been described in detail with reference to the drawings, and lastly, a variety of aspects of the present invention will be described.", "A electromagnetic device according to one or more embodiments of the present invention includes: a spool having a cylindrical body with a through hole; a secondary coil formed in a spiral shape along an outer peripheral surface of the cylindrical body and formed with a closed circuit by metal plating; and a primary coil formed of a conductive wire wound around the secondary coil via an insulating material covering the secondary coil.", "An induced current, generated by applying a voltage to any one of the primary coil and the secondary coil, is allowed to flow to the other coil different from the one coil.", "According to the first aspect of the present invention, with the secondary coil formed by metal plating, an electromagnetic device more compact in size and smaller in bulk than that of the conventional example can be obtained.", "Further, according to the first aspect of the present invention, there is no need to bind the extended wire of the coil to the coil terminal as in the conventional example, thus facilitating the connection work, so that an electromagnetic device with high productivity can be obtained.", "According to a second aspect of the present invention, in the first aspect, the guard portion may be provided at at least one end of the cylindrical body, and both ends of the secondary coil, formed on an outer peripheral surface of the cylindrical body, are electrically connected to each other by a lead wire formed by metal plating through a communication hole provided in the cylindrical body and the guard portion and an inner peripheral surface of the through hole in the cylindrical body.", "According to the second aspect, both ends of the secondary coil are connected by metal plating, thus eliminating the need to connect the both ends by the lead wire of the conductive wire.", "This can lead to further reduction in the occupied space and the size.", "This further facilitates the connection work, thereby enabling saving of labor, so that an electromagnetic device with even higher productivity can be obtained.", "In a third aspect of the present invention, in the second aspect, there may be provided an operation indicator lamp, fixed to the guard portion and electrically connected to the secondary coil.", "According to the third aspect, the operation indicator lamp provided on the guard portion is electrically connected to the secondary coil, thereby facilitating the connection work on the operation indicator lamp.", "In addition, with the operation indicator lamp installed directly on the guard portion, a large wiring space is not required and the device can thus be made more compact in size.", "Furthermore, the operation indicator lamp is lit by the induced current generated at the time when a voltage is applied to the primary coil, and hence an electromagnetic device with an energy saving can be obtained.", "In a fourth aspect of the present invention, in the third aspect, the operation indicator lamp may be a light-emitting diode (LED).", "According to the fourth aspect, it is possible to obtain an electromagnetic device provided with an operation indicator lamp with a further energy saving.", "An electromagnetic relay according to a fifth aspect of the present invention has a configuration in which the above electromagnetic device according to any one of the first to fourth aspects is incorporated into a base.", "According to the fifth aspect of the present invention, the secondary coil is formed by metal plating, so that the electromagnetic device is more compact in size and smaller in bulk than that of the conventional example It is thus possible to obtain a compact electromagnetic relay.", "It is not necessary to bind the extended wire of the coil to the coil terminal as in the conventional example, thus facilitating the connection work, so that an electromagnetic relay with high productivity can be obtained.", "According to a sixth aspect of the present invention, in the fifth aspect, a movable iron piece may be disposed so as to be attracted by magnetic force to a magnetic pole portion of an iron core protruding from the flange portion provided at at least one end of the cylindrical body among iron cores inserted through the through holes of the spool, the magnetic force being generated by applying a voltage to any one of the primary coil and the secondary coil, and the movable iron piece may be provided with a notch through which light of the operation indicator lamp is transmitted.", "According to the sixth aspect, the light of the operation indicator lamp provided on the guard portion of the electromagnetic device transmits through the notch provided in the movable iron piece, so that the light can be checked visually.", "It is therefore possible to visually check an operating state through the notch, thereby to obtain an electromagnetic relay with high safety and a user's sense of security.", "According to a seventh aspect of the present invention, in the sixth aspect, there may be provided an operation check window configured to transmit the light of the operation indicator lamp on an outer peripheral surface of a casing fitted to the base.", "According to the seventh aspect, the operation indicator lamp can be checked through the operation check window provided in the casing, and an electromagnetic relay with good usability can be obtained.", "According to an eighth aspect of the present invention, in the seventh aspect, the operation check window may be a transparent window provided in the casing.", "According to the eighth aspect, with no through hole provided in the casing, no fault occurs based on intrusion of dust or the like, and there is an effect that an electromagnetic relay with high reliability can be obtained.", "Note that by appropriately combining freely selected embodiments or modifications of the above variety of embodiments and modifications, it is possible to achieve the respective effects of those combined.", "While it is possible to combine embodiments, combine examples, or combine an embodiment and an example, it is also possible to combine features in different embodiments or examples.", "The electromagnetic device and the electromagnetic relay using the electromagnetic device according to the present invention are not limited to the above electromagnetic device and may be applied to other electromagnetic devices and electromagnetic relays incorporating the electromagnetic devices.", "While the present invention has been fully described in connection with the preferred embodiments with reference to the accompanying drawings, a variety of modifications or corrections will be apparent to those skilled in the art.", "Such modifications or corrections are to be understood as being included in the scope of the invention according to the appended claims so long as not deviating therefrom.", "DESCRIPTION OF SYMBOLS 10 electromagnetic relay 11 base 12 placement space 13 rib 14 press-fit groove 15 engaging claw portion 20 electromagnetic device 21 spool 22 cylindrical body 22a communication hole 23 through hole 24 guard portion 25 guard portion 24a communication hole 26 secondary coil 26a pattern 26b auxiliary pattern 26c lead wire 26d lead wire 26e lead wire 30 primary coil 31 iron core 31b magnetic pole portion 32 yoke 33 light emitting element 34 resistor 35 hinge spring 40 movable iron piece 41 horizontal portion 42 notch 50 contact mechanism 51 fixed contact terminal 51a normally closed fixed contact 52 movable touch piece 52a movable contact 53 fixed contact terminal 53a normally open fixed contact 60 card 61 operating protrusion 70 casing 71 engagement hole 72 operation check window" ] ]
Patent_15876072
[ [ "METHOD AND SYSTEM FOR VIRTUAL AND PHYSICAL NETWORK INTEGRATION", "The disclosure herein describes a virtual extensible local area network (VXLAN) gateway.", "During operation, the VXLAN gateway receives, from a physical host, an Ethernet packet destined for a virtual machine residing in a remote layer-2 network broadcast domain that is different from a local layer-2 network broadcast domain where the physical host resides.", "The VXLAN gateway then determines a VXLAN identifier for the received Ethernet packet.", "The VXLAN gateway further encapsulates the Ethernet packet with the virtual extensible local area network identifier and an Internet Protocol (IP) header, and forwards the encapsulated packet to an IP network, thereby allowing the packet to be transported to the virtual machine via the IP network and allowing the remote layer-2 network broadcast domain and the local layer-2 network broadcast domain to be part of a common layer-2 broadcast domain." ], [ "1-21.", "(canceled) 22.For a physical device separate from sources and destinations of packets in a network, a method for implementing a virtual extensible local area network (VXLAN) gateway, the method comprising: through an IP network to which the physical device implementing the gateway connects, receiving an encapsulated packet that originated from a virtual machine residing in a remote layer-2 network broadcast domain; decapsulating the packet by removing an IP header of the packet and identifying a VXLAN identifier for the packet, wherein an Ethernet packet remains after decapsulation; based at least in part on the VXLAN identifier, determining that a destination for the Ethernet packet is a server separate from the physical device implementing the gateway, the server residing in a local layer-2 network broadcast domain that is different from the remote layer-2 network broadcast domain; and forwarding the Ethernet packet to the server on the local layer-2 network broadcast domain.", "23.The method of claim 22 further comprising maintaining a data structure that maps the VXLAN identifier to at least one of (i) the server's medium access control (MAC) address and (ii) the server's virtual local area network (VLAN) tag.", "24.The method of claim 22, wherein the VXLAN gateway is a first VXLAN gateway, wherein the packet is encapsulated by a second VXLAN gateway to add the VXLAN identifier and IP header to the packet, wherein the method further comprises establishing a tunnel with the second VXLAN gateway.", "25.The method of claim 22 further comprising: receiving, from the server, a second Ethernet packet destined for the machine residing in the remote layer-2 network broadcast domain; encapsulating the second Ethernet packet with the VXLAN identifier and a second IP header; and forwarding the encapsulated second packet to the IP network, thereby allowing the packet to be transmitted to the remote layer-2 network broadcast domain.", "26.The method of claim 25 further comprising determining that the second Ethernet packet maps to the VXLAN identifier.", "27.The method of claim 22 further comprising receiving configuration information from a controller, wherein the configuration comprises mapping information that maps a set of addresses to the VXLAN identifier.", "28.The method of claim 27, wherein the controller is an OpenFlow controller, wherein the configuration information is received as a set of flows from the OpenFlow controller.", "29.The method of claim 22, wherein the destination of the Ethernet packet is a virtual machine that operates on the server, wherein a virtual switch that operates on the physical host is not configured to decapsulate packets with VXLAN identifiers.", "30.The method of claim 22, wherein the IP header comprises a destination address corresponding to the VXLAN gateway.", "31.The method of claim 22, wherein the server is a first server, the local layer-2 network broadcast domain is a first local layer-2 network broadcast domain, the encapsulated packet is a first encapsulated packet, the Ethernet packet is a first Ethernet packet, the machine is a first machine, the remote layer-2 network broadcast domain is a first remote layer-2 network domain, and the VXLAN identifier is a first VXLAN identifier, the method further comprising: receiving, through the IP network, a second encapsulated packet that originated from a second machine residing in a second remote layer-2 network broadcast domain; decapsulating the second packet by removing an IP header of the second packet and identifying a second VXLAN identifier for the packet, wherein a second Ethernet packet remains after decapsulation; and based at least in part on the second VXLAN identifier, determining that a destination for the second Ethernet packet is a second server separate from the physical device implementing the VXLAN gateway, the second server residing in the second local layer-2 network broadcast domain; and forwarding the second Ethernet packet to the second server on the second local layer-2 network broadcast domain.", "32.A non-transitory machine readable medium storing a program which when executed by a set of processing units of a physical device separate from sources and destinations of packets in a network implements a virtual extensible local area network (VXLAN) gateway, the program comprising sets of instructions for: through an IP network to which the physical device implementing the gateway connects, receiving an encapsulated packet that originated from a virtual machine residing in a remote layer-2 network broadcast domain; decapsulating the packet by removing an IP header of the packet and identifying a VXLAN identifier for the packet, wherein an Ethernet packet remains after decapsulation; based at least in part on the VXLAN identifier, determining that a destination for the Ethernet packet is a server separate from the physical device implementing the gateway, the server residing in a local layer-2 network broadcast domain that is different from the remote layer-2 network broadcast domain; and forwarding the Ethernet packet to the server on the local layer-2 network broadcast domain.", "33.The non-transitory machine readable medium of claim 32, wherein the program further comprises a set of instructions for maintaining a data structure that maps the VXLAN identifier to at least one of (i) the server's medium access control (MAC) address and (ii) the server's virtual local area network (VLAN) tag.", "34.The non-transitory machine readable medium of claim 32, wherein the VXLAN gateway is a first VXLAN gateway, wherein the packet is encapsulated by a second VXLAN gateway to add the VXLAN identifier and IP header to the packet, wherein the program further comprises a set of instructions for establishing a tunnel with the second VXLAN gateway.", "35.The non-transitory machine readable medium of claim 32 wherein the program further comprises sets of instructions for: receiving, from the server, a second Ethernet packet destined for the machine residing in the remote layer-2 network broadcast domain; encapsulating the second Ethernet packet with the VXLAN identifier and a second IP header; and forwarding the encapsulated second packet to the IP network, thereby allowing the packet to be transmitted to the remote layer-2 network broadcast domain.", "36.The non-transitory machine readable medium of claim 35, wherein the program further comprises a set of instructions for determining that the second Ethernet packet maps to the VXLAN identifier.", "37.The non-transitory machine readable medium of claim 32, wherein the program further comprises a set of instructions for receiving configuration information from a controller, wherein the configuration comprises mapping information that maps a set of addresses to the VXLAN identifier.", "38.The non-transitory machine readable medium of claim 37, wherein the controller is an OpenFlow controller, wherein the configuration information is received as a set of flows from the OpenFlow controller.", "39.The non-transitory machine readable medium of claim 32, wherein the destination of the Ethernet packet is a virtual machine that operates on the server, wherein a virtual switch that operates on the physical host is not configured to decapsulate packets with VXLAN identifiers.", "40.The non-transitory machine readable medium of claim 32, wherein the IP header comprises a destination address corresponding to the VXLAN gateway.", "41.The non-transitory machine readable medium of claim 32, wherein the server is a first server, the local layer-2 network broadcast domain is a first local layer-2 network broadcast domain, the encapsulated packet is a first encapsulated packet, the Ethernet packet is a first Ethernet packet, the machine is a first machine, the remote layer-2 network broadcast domain is a first remote layer-2 network domain, and the VXLAN identifier is a first VXLAN identifier, wherein the program further comprises sets of instructions for: receiving, through the IP network, a second encapsulated packet that originated from a second machine residing in a second remote layer-2 network broadcast domain; decapsulating the second packet by removing an IP header of the second packet and identifying a second VXLAN identifier for the packet, wherein a second Ethernet packet remains after decapsulation; and based at least in part on the second VXLAN identifier, determining that a destination for the second Ethernet packet is a second server separate from the physical device implementing the VXLAN gateway, the second server residing in the second local layer-2 network broadcast domain; and forwarding the second Ethernet packet to the second server on the second local layer-2 network broadcast domain." ], [ "<SOH> BACKGROUND <EOH>The exponential growth of the Internet has made it a ubiquitous delivery medium for a variety of applications.", "Such applications have in turn brought with them an increasing demand for bandwidth.", "As a result, service providers race to build larger and faster data centers with versatile capabilities.", "Meanwhile, advances in virtualization technologies have made it possible to implement a large number of virtual machines (VMs) in a data center.", "These virtual machines can essentially operate as physical hosts and perform a variety of functions such as Web or database servers.", "Because virtual machines are implemented in software, they can freely migrate to various locations.", "This capability allows service providers to partition and isolate physical resources (e.g., computing power and network capacity) according to customer needs, and to allocate such resources dynamically.", "While virtualization brings unprecedented flexibility to service providers, the conventional layer-2 network architecture, however, tends to be rigid and cannot readily accommodate the dynamic nature of virtual machines.", "For example, in conventional data center architecture, hosts are often inter-connected by one or more layer-2 (e.g., Ethernet) switches to form a layer-2 broadcast domain.", "The physical reach of a layer-2 broadcast domain is limited by the transmission medium.", "As a result, different data centers are typically associated with different layer-2 broadcast domains, and multiple layer-2 broadcast domains could exist within a single data center.", "For a VM in one data center to communicate with a VM or a storage device in another data center, such communication would need to be carried over layer-3 networks.", "That is, the packets between the source and destination have to be processed and forwarded by layer-3 devices (e.g., IP routers), since the source and destination belong to different layer-2 broadcast domains.", "While this architecture has benefits, flat layer-2 processing has its advantages.", "In fact, it would be desirable to exploit the advantages of both layer-3 and layer-2 models and processing capabilities in the network.", "One technique to solve the problems described above is to implement a virtual extensible local area network (VXLAN).", "VXLAN is a standard network virtualization technology managed by the Internet Engineering Task Force (IETF), and works by creating a logical layer-2 network that is overlaid above a layer-3 IP network.", "Ethernet packets generated by VMs are encapsulated in an IP header before they are transported to a remote data center where the IP header is removed and the original Ethernet packet is delivered to the destination.", "The IP encapsulation mechanism allows a logical layer-2 broadcast domain to be extended to an arbitrary number of remote locations, and allows different data centers or different sections of the same data center (and hence the VMs and devices therein) to be in the same layer-2 broadcast domain.", "The VXLAN function typically resides within a host's hypervisor, and works in conjunction with the hypervisor's virtual switch.", "More details of VXLAN can be found in IETF draft “VXLAN: A Framework for Overlaying Virtualized Layer 2 Networks over Layer 3 Networks,” available at https://tools.ietf.org/html/draft-mahalingam-dutt-dcops-vxlan-02, which is incorporated by reference here.", "Existing VXLAN implementations, however, cannot easily accommodate a mixture of physical hosts and VMs in the same logical layer-2 broadcast domain.", "This is because by default the VXLAN feature in a hypervisor encapsulates Ethernet packets generated by a VM that belongs to a certain VXLAN.", "A physical host, on the other hand, cannot easily participate in the same VXLAN because there is no mechanism to encapsulate the Ethernet packets it generates, which would otherwise allow the Ethernet packets to be delivered to other VXLAN-capable VMs." ], [ "<SOH> SUMMARY <EOH>The disclosure herein describes a network communication system that facilitates the integration of virtual and physical network devices.", "Specifically, the system provides a virtual extensible local area network (VXLAN) gateway.", "During operation, the VXLAN gateway receives, from a physical host, an Ethernet packet destined for a virtual machine residing in a remote layer-2 network broadcast domain that is different from a local layer-2 network broadcast domain where the physical host resides.", "The VXLAN gateway then determines a VXLAN network identifier (VNI) for the received Ethernet packet.", "The VXLAN gateway further encapsulates the Ethernet packet with the VNI and an Internet Protocol (IP) header, and forwards the encapsulated packet to an IP network, thereby allowing the packet to be transported to the virtual machine via the IP network and allowing the remote layer-2 network broadcast domain and the local layer-2 network broadcast domain to be part of a common layer-2 broadcast domain.", "Ethernet packet received from the physical host can be an address resolution protocol (ARP) request packet.", "In addition, the VXLAN gateway maintains a data structure that maps the VNI to an IP multicast group.", "The VXLAN gateway also sets a destination IP address in the IP header to be an IP address corresponding to the IP multicast group.", "The VXLAN gateway can also maintain a data structure that maps the physical host's medium access control (MAC) address and optionally the physical host's virtual local area network (VLAN) tag to the VNI.", "The data structure may also contain entries to encompass all the physical hosts on a specific VLAN.", "This is indicated as a mapping between the VNI and VLAN tag without any host-specific information.", "Additionally, the VXLAN gateway can receive a packet from the virtual machine, wherein the packet includes an outer Ethernet header, an IP header, and an inner Ethernet header.", "The VXLAN gateway then decapsulates the packet received from the virtual machine by removing its outer Ethernet header and IP header and forwards the decapsulated packet to the physical host.", "The VXLAN gateway can further establish a tunnel with a second virtual extensible local area network gateway, thereby joining two layer-2 network broadcast domains with a common VNI.", "Optionally, the VXLAN gateway can receive configuration information from an OpenFlow controller." ], [ "RELATED APPLICATION This application claims the benefit of U.S.", "Provisional Application No.", "61/683,100, Attorney Docket Number A954.PRO, entitled “VIRTUAL AND PHYSICAL NETWORKING INTEGRATION WITH VXLAN GATEWAYS,” by inventors Thayumanavan Sridhar and Margaret Petrus, filed 14 Aug. 2012.BACKGROUND The exponential growth of the Internet has made it a ubiquitous delivery medium for a variety of applications.", "Such applications have in turn brought with them an increasing demand for bandwidth.", "As a result, service providers race to build larger and faster data centers with versatile capabilities.", "Meanwhile, advances in virtualization technologies have made it possible to implement a large number of virtual machines (VMs) in a data center.", "These virtual machines can essentially operate as physical hosts and perform a variety of functions such as Web or database servers.", "Because virtual machines are implemented in software, they can freely migrate to various locations.", "This capability allows service providers to partition and isolate physical resources (e.g., computing power and network capacity) according to customer needs, and to allocate such resources dynamically.", "While virtualization brings unprecedented flexibility to service providers, the conventional layer-2 network architecture, however, tends to be rigid and cannot readily accommodate the dynamic nature of virtual machines.", "For example, in conventional data center architecture, hosts are often inter-connected by one or more layer-2 (e.g., Ethernet) switches to form a layer-2 broadcast domain.", "The physical reach of a layer-2 broadcast domain is limited by the transmission medium.", "As a result, different data centers are typically associated with different layer-2 broadcast domains, and multiple layer-2 broadcast domains could exist within a single data center.", "For a VM in one data center to communicate with a VM or a storage device in another data center, such communication would need to be carried over layer-3 networks.", "That is, the packets between the source and destination have to be processed and forwarded by layer-3 devices (e.g., IP routers), since the source and destination belong to different layer-2 broadcast domains.", "While this architecture has benefits, flat layer-2 processing has its advantages.", "In fact, it would be desirable to exploit the advantages of both layer-3 and layer-2 models and processing capabilities in the network.", "One technique to solve the problems described above is to implement a virtual extensible local area network (VXLAN).", "VXLAN is a standard network virtualization technology managed by the Internet Engineering Task Force (IETF), and works by creating a logical layer-2 network that is overlaid above a layer-3 IP network.", "Ethernet packets generated by VMs are encapsulated in an IP header before they are transported to a remote data center where the IP header is removed and the original Ethernet packet is delivered to the destination.", "The IP encapsulation mechanism allows a logical layer-2 broadcast domain to be extended to an arbitrary number of remote locations, and allows different data centers or different sections of the same data center (and hence the VMs and devices therein) to be in the same layer-2 broadcast domain.", "The VXLAN function typically resides within a host's hypervisor, and works in conjunction with the hypervisor's virtual switch.", "More details of VXLAN can be found in IETF draft “VXLAN: A Framework for Overlaying Virtualized Layer 2 Networks over Layer 3 Networks,” available at https://tools.ietf.org/html/draft-mahalingam-dutt-dcops-vxlan-02, which is incorporated by reference here.", "Existing VXLAN implementations, however, cannot easily accommodate a mixture of physical hosts and VMs in the same logical layer-2 broadcast domain.", "This is because by default the VXLAN feature in a hypervisor encapsulates Ethernet packets generated by a VM that belongs to a certain VXLAN.", "A physical host, on the other hand, cannot easily participate in the same VXLAN because there is no mechanism to encapsulate the Ethernet packets it generates, which would otherwise allow the Ethernet packets to be delivered to other VXLAN-capable VMs.", "SUMMARY The disclosure herein describes a network communication system that facilitates the integration of virtual and physical network devices.", "Specifically, the system provides a virtual extensible local area network (VXLAN) gateway.", "During operation, the VXLAN gateway receives, from a physical host, an Ethernet packet destined for a virtual machine residing in a remote layer-2 network broadcast domain that is different from a local layer-2 network broadcast domain where the physical host resides.", "The VXLAN gateway then determines a VXLAN network identifier (VNI) for the received Ethernet packet.", "The VXLAN gateway further encapsulates the Ethernet packet with the VNI and an Internet Protocol (IP) header, and forwards the encapsulated packet to an IP network, thereby allowing the packet to be transported to the virtual machine via the IP network and allowing the remote layer-2 network broadcast domain and the local layer-2 network broadcast domain to be part of a common layer-2 broadcast domain.", "Ethernet packet received from the physical host can be an address resolution protocol (ARP) request packet.", "In addition, the VXLAN gateway maintains a data structure that maps the VNI to an IP multicast group.", "The VXLAN gateway also sets a destination IP address in the IP header to be an IP address corresponding to the IP multicast group.", "The VXLAN gateway can also maintain a data structure that maps the physical host's medium access control (MAC) address and optionally the physical host's virtual local area network (VLAN) tag to the VNI.", "The data structure may also contain entries to encompass all the physical hosts on a specific VLAN.", "This is indicated as a mapping between the VNI and VLAN tag without any host-specific information.", "Additionally, the VXLAN gateway can receive a packet from the virtual machine, wherein the packet includes an outer Ethernet header, an IP header, and an inner Ethernet header.", "The VXLAN gateway then decapsulates the packet received from the virtual machine by removing its outer Ethernet header and IP header and forwards the decapsulated packet to the physical host.", "The VXLAN gateway can further establish a tunnel with a second virtual extensible local area network gateway, thereby joining two layer-2 network broadcast domains with a common VNI.", "Optionally, the VXLAN gateway can receive configuration information from an OpenFlow controller.", "BRIEF DESCRIPTION OF FIGURES FIG.", "1 illustrates an exemplary network architecture that facilitates a VXLAN gateway.", "FIG.", "2 illustrates header format for a conventional Ethernet packet and its VXLAN encapsulation.", "FIG.", "3 presents a time-space diagram illustrating an exemplary process of a physical host initiating communication with a VM across an IP network, via a VXLAN gateway.", "FIG.", "4 presents a flow chart illustrating an exemplary process of a physical host communicating with a VM via a VXLAN gateway.", "FIG.", "5 illustrates an exemplary network architecture where two remotely located data centers are joined to form a single layer-2 broadcast domain by VXLAN gateways.", "FIG.", "6 illustrates an exemplary network architecture that facilitates configuration of a VXLAN gateway using an OpeFlow controller.", "FIG.", "7 illustrates an exemplary computer system that facilitates a VXLAN gateway.", "In the figures, like reference numerals refer to the same figure elements.", "DETAILED DESCRIPTION The following description is presented to enable any person skilled in the art to make and use the embodiments, and is provided in the context of a particular application and its requirements.", "Various modifications to the disclosed embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be applied to other embodiments and applications without departing from the spirit and scope of the present disclosure.", "Thus, the present invention is not limited to the embodiments shown, but is to be accorded the widest scope consistent with the principles and features disclosed herein.", "Embodiments of the system disclosed herein solve the problem of enabling VXLAN-encapsulated communication between a VM and a physical host by facilitating a VXLAN gateway, which serves as a gateway for the physical host and performs VXLAN encapsulation and decapsulation on behalf of the physical host.", "As mentioned above, the VXLAN feature in a hypervisor (such as the ESX® product family by VMware, Inc. of Palo Alto, Calif.) automatically encapsulates an Ethernet packet generated by a VM that is part of a VXLAN-enabled Ethernet broadcast domain.", "There is currently no ready-to-use mechanism that can allow a physical host, which does not have this VXLAN feature in its protocol stack, to participate in this VXLAN-enabled broadcast domain.", "This is because there is no device in the network that can encapsulate the physical host's Ethernet packet with VXLAN headers.", "To solve this problem, a VXLAN gateway residing in the same layer-2 broadcast domain as the physical host can perform the VXLAN encapsulation and decapsulation on behalf of the physical host.", "FIG.", "1 illustrates an exemplary network architecture that facilitates a VXLAN gateway.", "In this example, an IP network 100 couples several conventional layer-2 networks.", "Specifically, a host 102 is coupled to an IP router 130.Host 102 hosts a number of VMs: 108, 110, and 112.VMs 108 and 110 belong to VXLAN 1, and VM 112 belongs to VXLAN 2.Virtualization software 104 (such as a hypervisor) manages the VMs in host 102, and includes a VXLAN module 106.VXLAN module 106 is responsible for encapsulating and decapsulating the Ethernet packets generated by VMs 108, 110, and 112.Similarly, a host 103 is coupled to an IP router 132.Host 103 hosts a number of VMs: 118, 120, and 122.VM 118 belongs to VXLAN 1, and VMs 120 and 122 belong to VXLAN 2.Virtualization software 114 manages VMs 118, 120, and 122, and includes a VXLAN module 116.When VMs within the same VXLAN communicate with each other, the Ethernet packet generated by a VM is encapsulated with an IP header and then delivered to the VXLAN module in the destination physical host (which owns the destination IP address).", "For example, when VM 108 communicates with VM 118, VM 108 generates an Ethernet packet with VM 118's MAC address as its MAC destination address (DA).", "(Note that VMs within the same VXLAN are in the same logical layer-2 broadcast domain, and are therefore assumed to learn each other's MAC address.)", "When this Ethernet packet reaches VXLAN module 106, VXLAN module 106 inspects the packet's MAC source address (SA), MAC DA, and optionally VLAN tag, and determines that both the source (VM 108) and destination (VM 118) belong to VXLAN 1.Furthermore, based on the packet's MAC DA, VXLAN module 106 determines the IP address of the destination physical host 103.In turn, VXLAN module 106 encapsulates this Ethernet packet with a proper VXLAN header and IP header (which will be described in more detail in conjunction with FIG.", "2), and transmits this encapsulated packet to IP router 130.Since the encapsulated packet has an IP destination address that is associated with host 103, IP router 130 (and other IP routers in IP network 100) can then make the proper forwarding decision and forwards the encapsulated packet toward host 103.When host 103 receives the encapsulated packet, VXLAN module 116 first removes the IP header to expose the inner Ethernet packet.", "Subsequently, based on both the VNI and the inner Ethernet header's MAC DA, virtualization software 114 forwards the inner Ethernet packet to VM 118.Note that when VXLAN 116 receives the Ethernet packet, it can establish a mapping relationship of the MAC SA of the inner Ethernet packet (which is VM 108's MAC address) and the IP source address (which is host 102's IP address).", "Hence, when in the future VM 118 sends an Ethernet packet to VM 108, VXLAN module 116 can perform VXLAN encapsulation with host 102's IP address as the IP destination address.", "In the situation where a source VM does not have knowledge of a destination VM's MAC address (and only the destination VM's IP address), the source VM typically issues an address resolution protocol (ARP) request with the destination VM's IP address.", "This ARP request is a broadcast layer-2 message, which is supposed to be received by all the hosts (and VMs) in a layer-2 broadcast domain.", "In the case of VXLAN, for example, when VM 108 sends out an ARP request, this ARP request first reaches VXLAN module 106.In turn, when VXLAN module 106 determines that it is an ARP request that is supposed to be broadcast to the entire VXLAN, VXLAN module 106 encapsulates the ARP request with an IP header that has an IP multicast group address as its destination IP address.", "That is, each VXLAN is associated with an IP multicast tree that includes all the physical hosts in the VXLAN.", "This way, when there is a broadcast packet for the entire VXLAN, a VXLAN module in a host's hypervisor can encapsulate the packet with an IP multicast header, and multicast this encapsulated packet to all the hosts in the VXLAN.", "Hence, the ARP request would be multicast to all the hosts associated with the same VXLAN.", "The VXLAN module on each receiving host would decapsulate the packet, and locally broadcast the inner ARP request to all the VMs belonging to that VXLAN.", "In response, the VM that has an IP address that matches the one in the ARP request produces an ARP response, which would be encapsulated by the local VXLAN module and unicast back to the requesting VM.", "In the example illustrated in FIG.", "1, if a physical host (or a VM that is not VXLAN-capable) is coupled to IP network 100, either directly or via a layer-2 switch, it would be difficult, if not impossible, for the physical host to communicate with any VM that belongs to a VXLAN, because an Ethernet packet from the physical host cannot be delivered to any of the VMs since the Ethernet packet is not probably encapsulated with a VXLAN header and IP header.", "One solution is to use a VXLAN gateway 124, which can be a stand-alone device that performs the functions of VXLAN module 106 or 108.For example, a physical host 126 can be coupled to VXLAN gateway 124 via a layer-2 switch 127.Physical host 126 belongs to VLAN 1, which is mapped to VXLAN 1 by VXLAN gateway 124.A physical host 128 can host a number of VMs 138, 140, and 142, which are not VXLAN enabled.", "VM 138 belongs to VLAN 1, which maps to VXLAN 1.VMs 140 and 142 belong to VLAN 2, which maps to VXLAN 2.Host 128 is also coupled to VXLAN gateway 124.When physical host 126 is to communicate with VM 108, physical host 126 can send out an Ethernet packet with VM 108's MAC address as the MAC DA, its own MAC address as the MAC SA, and a VLAN tag corresponding to VLAN 1.When this Ethernet packet reaches VXLAN gateway 124, VXLAN gateway 124 inspects the packet's MAC SA and MAC DA, and its VLAN tag.", "Note that VXLAN gateway maintains a set of mapping information that maps a MAC address and optionally a VLAN tag to a VXLAN.", "Note that the data structure to maintain the mapping information may also contain entries to encompass all the physical hosts on a specific VLAN.", "This is indicated as a mapping between the VNI and VLAN tag without any host-specific information.", "If physical host 126 is properly configured, VXLAN gateway 124 would identify the Ethernet packet's MAC SA and MAC DA (and optionally VLAN tag) to be associated with VXLAN 1.", "(Note that if the VLAN tag is present, VXLAN gateway 124 may directly map the VLAN to a VXLAN without using the MAC addresses.", "If VLAN is not configured, however, VXLAN gateway 124 can map the MAC SA, MAC DA, or both, to the VXLAN.)", "Furthermore, VXLAN gateway 124 also maintains a set of mapping information between a VM's MAC address and the IP address of that VM's physical host.", "Hence, based on the MAC DA of the Ethernet packet generated by physical host 126, which is VM 108's MAC address, VXLAN gateway 124 determines that host 102's IP address should be used as the destination IP address for the VXLAN encapsulation.", "In addition, VXLAN gateway 124 uses its own IP address as the source IP address for the encapsulation.", "Subsequently, VXLAN encapsulates the Ethernet packet from host 126 with the proper VXLAN header and IP header and transmits the encapsulated packet to IP network 100.When the encapsulated packet reaches host 102, the encapsulated packet is forwarded to VXLAN module 106.VXLAN module 106 in turn removes the IP header to obtain the inner Ethernet packet.", "Note that VXLAN module 106 can learn the mapping between the source IP address of the IP header (which is VXLAN gateway 124's IP address) and the MAC SA of the inner Ethernet packet (which is host 126's MAC address).", "This mapping information is used to encapsulate outbound traffic to host 126.Subsequently, VXLAN module 106 forwards the inner Ethernet packet to VM 108 based on the MAC DA.", "When VM 108 sends an Ethernet packet back to host 126, a similar VXLAN encapsulation/decapsulation process takes place.", "Specifically, VXLAN module 106 identifies that the Ethernet packet from VM 108 to host 126 belongs to VXLAN 1.Furthermore, based on the Ethernet packet's MAC DA (which is host 126's MAC address), VXLAN module 106 identifies host 126's IP address as the destination IP address for the VXLAN encapsulation, and uses host 102's IP address as the source IP address.", "Host 102 then sends the encapsulated Ethernet packet to IP network 100, which delivers the packet to VXLAN gateway 124.VXLAN gateway 124 then decapsulates the packet by removing its IP header, and forwards the inner Ethernet packet to host 126.FIG.", "2 illustrates header format for a conventional Ethernet packet and its VXLAN encapsulation.", "In this example, a conventional Ethernet packet 200 typically includes a payload 203 and an Ethernet header 208.Typically, payload 203 can include an IP packet which includes an IP header 206.Ethernet header 208 includes a MAC DA 204, a MAC SA 202, and optionally a VLAN tag 205.In one embodiment, VXLAN gateway 124 can encapsulate conventional Ethernet packet 200 into an encapsulated packet 220.Encapsulated packet 220 typically includes a VXLAN header 222 which contains a VNI to indicate the VXLAN to which inner Ethernet packet 200 belongs, a UDP header 218 which indicates the transport-layer protocol and port number reserved for VXLAN, and an outer IP header 210.In addition, encapsulated packet 220 includes an outer Ethernet header 212.Take, for example, Ethernet packet 200 as an Ethernet packet generated by host 126 and destined for VM 108.Typically, an upper layer application in host 126 would generate an IP packet destined for VM 108, using VM 108's IP address.", "This IP packet becomes payload 203, and VM 108's IP address would be the destination IP address in IP header 206.In addition, host 126's IP address would be the source IP address in IP header 206.The datalink layer in host 126 then generates Ethernet header 208 to encapsulate payload 203.MAC DA 204 of Ethernet header 208 would be VM 108's MAC address, and MAC SA 202 of Ethernet header 208 would be host 126's MAC address.", "This is based on the assumption that host 126 has learned VM 108's MAC address.", "In the case where host 126 does not have knowledge of VM 108's MAC address, host 126 can use ARP to discover VM 108's MAC address.", "This ARP process is described in conjunction with FIG.", "3.Host 126 then sends Ethernet packet 200 to VXLAN gateway 124.When VXLAN gateway 124 receives Ethernet packet 200 from host 126, VXLAN gateway 124 inspects the Ethernet MAC DA 204, MAC SA 202, and optionally VLAN tag 205.Based on this information VXLAN gateway 124 determines that Ethernet packet 200 is associated with VXLAN 1.Furthermore, based on MAC DA 204, VXLAN gateway 124 determines that the destination IP address for VXLAN encapsulation is the IP address of host 102.Subsequently, VXLAN gateway 124 assembles the VXLAN header which includes VXLAN header 222 (corresponding to VXLAN 1), and attaches UDP header 218 which includes the appropriate UDP port number.", "In addition, VXLAN gateway 124 assembles outer IP header 210 which uses host 102's IP address as the destination address, and VXLAN gateway 124's own IP address as the source address.", "VXLAN gateway 124 then assembles an outer Ethernet header 212.Outer Ethernet header 212 is used to transport packet 220 from VXLAN gateway 124 to the next-hop IP router 134.Outer Ethernet header 212 has a MAC DA 214 which is IP router 134's MAC address, a MAC SA which is VXLAN gateway 124's MAC address, and optionally an outer VLAN tag 217.Once packet 220 reaches IP router 134, IP router 134 can remove outer Ethernet header 212 and forward the packet based on outer IP header 210.This process continues throughout IP network 100 until the packet reaches host 102.As mentioned above, when host 126 attempts to communicate with VM 108 for the very first time, host 126 might only have VM 108's IP address but not its MAC address.", "To discover VM 108's MAC address, host 126 can perform an ARP query operation.", "FIG.", "3 presents a time-space diagram illustrating this process.", "Initially, host 126 generates an ARP request message which is carried in an Ethernet broadcast packet 302.Host 126 then transmits broadcast packet 302 to VXLAN gateway 124.In turn, VXLAN gateway 124 identifies that host 126 belongs to VXLAN 1 based on the MAC SA of packet 302.In addition, since packet 302 is an Ethernet broadcast packet, VXLAN gateway 124 maps packet 302 to an IP multicast group corresponding to VXLAN 1, and generates an IP multicast header 303 to encapsulate packet 302.Note that the IP multicast group includes both hosts 102 and 103, since these two hosts both host VMs belonging to VXLAN 1 (VMs 108 and 110 on host 102, and VM 118 on host 103).", "This IP multicast packet is then delivered by IP network 100 to both hosts 102 and 103.VXLAN module 106 on host 102 then removes IP header 303 from packet 302 and locally broadcasts packet 302 to all the VMs (i.e., VMs 108 and 110) belonging to VXLAN 1.In addition, VXLAN module 106 learns the mapping between host 126's MAC address, which is the MAC SA in packet 302, and the corresponding IP address, which is VXLAN gateway 124's IP address and the source IP address in the IP multicast packet.", "Similarly, VXLAN module 116 on host 103 receives the same IP multicast packet and forwards the inner Ethernet broadcast packet 302 to VM 118 (not shown in FIG.", "3).", "Subsequently, VM 108 determines and its IP address matches the IP address in the ARP request in packet 302.In response, VM 108 generates an ARP response message and encapsulates it in an Ethernet unicast packet 304, which has host 126's MAC address as the MAC DA and VM 108's own MAC address as the MAC SA.", "VXLAN module 106 on host 102 then encapsulates packet 304 with a unicast IP header 305.The source IP address of IP header 305 is host 102's IP address, and the destination IP address is VXLAN gateway 124's IP address.", "When this unicast IP packet reaches VXLAN gateway 124, VXLAN gateway 124 removes IP header 305, and forwards the inner Ethernet packet 304 to host 126.In turn, host 126 retrieves the ARP response carried in packet 304, and learns VM 108's MAC address.", "Next, host 126 generates a regular unicast Ethernet packet 306 that carries a payload to VM 108.The MAC DA of packet 306 is VM 108's MAC address, which was learned by host 126 based on packet 304 (the ARP response).", "The MAC SA of packet 306 is host 126's MAC address.", "VXLAN gateway 124 then encapsulates packet 306 with a VXLAN header followed by a unicast IP header 307.IP header 307 has host 102's IP address as its destination IP address, and VXLAN gateway 124's IP address as its source IP address.", "Subsequently, VXLAN module 106 on host 102 removes IP header 307 and forwards inner Ethernet packet 306 to VM 108.When VM 108 sends an Ethernet packet 308 in return, VXLAN module 106 encapsulates packet 308 with a unicast IP header 309.Unicast IP header 309 has VXLAN gateway 124's IP address as its destination IP address, and host 102's IP address as its source IP address.", "VXLAN gateway 124 then receives the encapsulated packet, removes IP header 309, and forwards inner Ethernet packet 308 to host 126.FIG.", "4 presents a flow chart illustrating a general process of a physical host communicating with a VM via a VXLAN gateway.", "During operation, to initiate communication with a VM in a VXLAN, a physical host first broadcasts an ARP request which reaches the VXLAN gateway (operation 402).", "In response, the VXLAN gateway maps the ARP request to a particular VXLAN and the corresponding IP multicast group based on the physical host's MAC address and optionally its VLAN tag (operation 404).", "The VXLAN gateway encapsulates the ARP request with a VXLAN header, a UDP header, and an outer IP header (which includes an IP multicast group address as destination IP address) and an outer Ethernet header (operation 406).", "The VXLAN gateway then transmits the encapsulated packet to the IP network (operation 408).", "The encapsulated packet is delivered by the IP network to all the hosts that host VMs belonging to the same VXLAN.", "As a result, a VXLAN-enabled hypervisor on the host which hosts the VM corresponding to the ARP request receives the encapsulated packet, decapsulates the packet, and forwards the inner ARP request to the VMs belonging to the same VXLAN and running on the host (operation 410).", "Subsequently, the VM with an IP address matching the ARP request responds to the ARP request (operation 412).", "In response, the hypervisor for the VM encapsulates the ARP response with the VXLAN gateway's IP address as the destination IP address and transmits the encapsulated packet to the IP network (operation 414).", "Next, the VXLAN gateway receives the encapsulated ARP response packet and decapsulates it (operation 416).", "The VXLAN gateway then forwards the decapsulated ARP response packet to the physical host (operation 418).", "In turn, the physical host learns the destination VM's MAC address (operation 420).", "The physical host subsequently can proceed to communicate with the VM using the VM's MAC address as if the VM is residing in the same layer-2 broadcast domain (operation 422).", "In some embodiments, in addition to providing the VXLAN function to a non-VXLAN-enabled physical host, VXLAN gateways can also “stitch” two data centers which are not VXLAN-capable into one VXLAN domain with a common VXLAN ID.", "To facilitate such “stitching,” two VXLAN gateways residing within two data centers respectively establish a tunnel (which for example can be IP-based, such as IPSEC based, tunnel in one embodiment) between them.", "In one embodiment, this tunnel is an IPsec tunnel.", "The two VXLAN gateways can transparently pass through packets from one data center to the other, hence joining two data centers into a single broadcast domain.", "Note that IPsec tunnel is used as an example, and any tunneling protocol can be used by the two VXLAN gateways.", "FIG.", "5 illustrates an exemplary network architecture where two remotely located data centers are joined to form a single layer-2 broadcast domain by VXLAN gateways.", "In this example, host 504 hosts VMs 518, 520, and 522.Host 506 hosts VMs 508, 510, and 512.Host 504 is coupled to VXLAN gateway 516, and host 506 is coupled to VXLAN gateway 516.VXLAN gateways 516 and 506 are both coupled to IP network 500, and have established a tunnel 515 between them.", "During operation, each VXLAN gateway maintains a set of mapping information that maps not only the local MAC addresses to the VXLAN, but also the MAC addresses in the remote data center to the VXLAN.", "For example, when VM 508 sends out an Ethernet packet destined for VM 518, VXLAN gateway 514 would encapsulate this Ethernet packet with the VXLAN and IP headers, and send this encapsulated packet via tunnel 515 to VXLAN gateway 516.VXLAN gateway 516 in turn would decapsulate the packet and send the inner Ethernet packet to host 504, which can forward it to VM 518.Essentially, VXLAN gateways 516 and 506 provide the functionality of a VXLAN module in a VXLAN-enabled hypervisor.", "As mentioned above, a VXLAN gateway typically maintains a set of mapping information, which maps a MAC address and (optionally) a VLAN tag to a VXLAN ID.", "Furthermore, the VXLAN encapsulation requires mapping a MAC DA to a destination IP address (either unicast or multicast, depending on the inner Ethernet).", "In one embodiment, an OpenFlow controller can facilitate such configuration of each VXLAN gateway in the network, as illustrated in FIG.", "6.In this example, all the mapping information (which is stored in the form of flow definition) is communicated from an OpenFlow controller 602 to VXLAN gateway 124 via a secure (e.g., SSL) tunnel 604.The configuration information provided by OpenFlow controller 602 can be used by VXLAN gateway 124 to build a forwarding table containing entries for specific flows.", "Each flow is defined using a 12 tuple value {MAC DA, MAC SA, Ethertype, Source IP, Destination IP, etc.", ".", ".", ". }", "with the possibility of using wildcards in any field.", "More details on OpenFlow can be found in https://www.opennetworking.org/images/stories/downloads/specification/openflow-spec-v1.2.pdf, which is incorporated by reference herein.", "It should be noted that the VXLAN gateway described herein can be implemented as a stand-alone appliance, as part of a switch or router, or as part of a host.", "Furthermore, the VXLAN gateway can be implemented in hardware or software, or a combination of both.", "FIG.", "7 illustrates an exemplary computer system that facilitates a VXLAN gateway.", "In this example, a computer system 702 includes a processor 704, memory 706, and a storage device 708.Computer system 702 is also coupled to a display 710, a keyboard 712, and a pointing device 708.Storage device 708 stores data 730 and instructions which when loaded into memory 706 and executed by processor 704 implement an operating system 716 and a VXLAN gateway system 718.Gateway system 718 includes a communication module 720, a VXLAN mapping module 722, a packet encapsulation module 724, an IP tunnel module 726, and an OpenFlow module 728.When executed by the processor, these modules jointly or separately perform the functions described above.", "The data structures and code described in this detailed description are typically stored on a computer-readable storage medium, which may be any device or medium that can store code and/or data for use by a computer system.", "The computer-readable storage medium includes, but is not limited to, volatile memory, non-volatile memory, magnetic and optical storage devices such as disk drives, magnetic tape, CDs (compact discs), DVDs (digital versatile discs or digital video discs), or other media capable of storing computer-readable media now known or later developed.", "The methods and processes described in the detailed description section can be embodied as code and/or data, which can be stored in a computer-readable storage medium as described above.", "When a computer system reads and executes the code and/or data stored on the computer-readable storage medium, the computer system performs the methods and processes embodied as data structures and code and stored within the computer-readable storage medium.", "Furthermore, the methods and processes described above can be included in hardware modules.", "For example, the hardware modules can include, but are not limited to, application-specific integrated circuit (ASIC) chips, field-programmable gate arrays (FPGAs), and other programmable-logic devices now known or later developed.", "When the hardware modules are activated, the hardware modules perform the methods and processes included within the hardware modules.", "The foregoing descriptions of embodiments of the present invention have been presented for purposes of illustration and description only.", "They are not intended to be exhaustive or to limit the present invention to the forms disclosed.", "Accordingly, many modifications and variations will be apparent to practitioners skilled in the art.", "Additionally, the above disclosure is not intended to limit the present invention.", "The scope of the present invention is defined by the appended claims." ] ]
Patent_15876077
[ [ "Depth Controllable and Measurable Medical Driver Devices and Methods of Use", "Disclosed are devices and methods for creating a bore in bone.", "The devices and methods described involve controlling the drive and measuring the drilling energy of a working tool such that a user can avoid injuries to surrounding structures." ], [ "1.A driving device comprising: a housing having a proximal end and a distal end; a motor contained within the housing; a gearbox connecting the motor to a working tool interchangeably connected via a coupler, wherein the motor turns the gearbox, the coupler and the working tool; a torque sensor configured to measure drilling torque at an output of the gearbox and convert the measured drilling torque into a torque measurement signal, wherein the drilling torque is in a direction opposite rotation of the working tool, wherein the gearbox has a gearbox torque in a direction opposite rotation of the working tool, and wherein the gearbox is held as a reference point such that the gearbox torque is excluded from the torque measurement signal; a programmable electronics package programmed to keep constant rotations per minute (RPM) of the motor preventing working tool rotational acceleration or deceleration, and programmed to integrate over time the torque measurement signal from the torque sensor to obtain a measurement of drilling energy of the working tool; and a tool guide assembly coupled to the housing, wherein upon actuation, axial motion of the tool guide assembly towards the proximal end of the housing to a retracted state allows a length of the working tool to be driven into a target region of work.", "2.The device of claim 1, wherein the tool guide assembly comprises: a tool guide configured to surround at least a portion of the working tool; and a surface guide having a proximal region and a distal region, the distal region configured to couple to the tool guide and the proximal region configured to couple to the housing.", "3.The device of claim 1, wherein a change in the drilling energy corresponds to a change in material strength and density of work penetrated.", "4.The device of claim 3, further comprising an alert, wherein the torque sensor communicates with the programmable electronics package in real-time and the alert provides a user with information regarding status of the driving device during use.", "5.The device of claim 4, wherein the alert comprises an auditory, visual or tactile signal.", "6.The device of claim 3, wherein the work penetrated comprises medullary canal, cancellous bone, cortical bone, or soft tissue.", "7.The device of claim 1, wherein the working tool is selected from the group consisting of a drill bit, a detuned drill bit, wire, Kirschner wire, pin, trochar, burr, screwdriver, reamer, saw, saw blade, router, router bit, stepped drill bit, bone plug removal tool, bone harvesting tool, bone marrow harvesting tool, and bone marrow aspirating tool.", "8.The device of claim 1, further comprising one or more axial force sensors configured to sense the axial force applied at one or both of the distal end of the tool guide and the working tool, wherein the programmable electronics package is further programmed to obtain a measurement of work done by the working tool based on the axial force and a linear distance traveled by the tool guide assembly and/or the length of the working tool driven into the target region.", "9.The device of claim 8, wherein the programmable electronics package is further programmed to obtain a measurement of drilling energy based on the measurement of work.", "10.The device of claim 8, further comprising an axial force alert, wherein the axial force sensor communicates with the programmable electronics package in real-time and the axial force alert provides a user with information regarding status of the driving device during use.", "11.The device of claim 10, wherein the axial force alert comprises an auditory, visual or tactile signal.", "12.The device of claim 11, wherein the visual signal comprises one or more LEDs positioned within a user line-of-sight, wherein the LEDs indicate degree of axial force being applied by the user to the tool guide in real-time.", "13.The device of claim 8, wherein the one or more axial force sensors comprises a tool guide sensor configured to sense and signal the axial force applied by the user to the tool guide.", "14.The device of claim 13, wherein the one or more axial force sensors comprises a working tool sensor configured to sense and signal the axial force applied by the user to the working tool, wherein the degree of axial force being applied to the tool guide is provided separately from the degree of axial force being applied to the working tool.", "15.The device of claim 14, wherein the degree of axial force being applied to the tool guide and the degree of axial force being applied to the working tool equals the total user force applied to the device.", "16.The device of claim 2, wherein the tool guide at least partially surrounding the working tool is configured to assist in the engagement of an implant.", "17.The device of claim 16, wherein the tool guide comprises one or more features that mechanically couple with corresponding features of the implant.", "18.The device of claim 16, wherein the implant comprises a fracture fixation plate or a joint part.", "19.The device of claim 16, wherein the tool guide couples to the implant at an angle away from perpendicular.", "20.The device of claim 1, wherein a change in current used to drive the motor is received by the programmable electronics package signaling when to stop the axial motion of the tool guide assembly and preventing penetration of the working tool beyond the target region of the work.", "21.The device of claim 1, wherein the torque sensor is coupled to the housing and to the motor such that the torque sensor couples the motor to the housing.", "22.The device of claim 2, further comprising a second motor contained within the housing, wherein the proximal region of the surface guide is coupled to the second motor.", "23.The device of claim 22, wherein the second motor is configured to cause the axial motion of the tool guide assembly toward the proximal end of the housing.", "24.The device of claim 22, wherein the first motor is coupled to a first drive shaft and the second motor is coupled to a second drive shaft.", "25.The device of claim 24, wherein the first drive shaft and the second drive shaft are in a co-axial, parallel, or orthogonal arrangement relative to one another.", "26.The device of claim 24, wherein the surface guide comprises a forward surface guide and a rear surface guide, wherein a distal region of the forward surface guide couples to the tool guide and a proximal region of the forward surface guide couples to the rear surface guide, and wherein the rear surface guide couples to the second drive shaft.", "27.The device of claim 26, wherein the rear surface guide is attached to a drive lug coupled to and powered by the second motor to move the rear surface guide in an axial direction.", "28.The device of claim 26, wherein the forward surface guide comprises at least one support that mates with corresponding support of the rear surface guide.", "29.The device of claim 26, wherein the forward surface guide engages an outer surface of the coupler.", "30.The device of claim 1, wherein the tool guide assembly is configured to be removed away from the working tool.", "31.The device of claim 1, wherein contact between the tool guide assembly and the working tool is prevented by maintaining the tool guide assembly coaxial with a longitudinal axis of the working tool." ], [ "<SOH> BACKGROUND <EOH>Orthopedic surgery can require bone drilling for the repair of fractures or insertion of implants or other devices.", "The resulting holes can be used to accept screws, implants and other devices to exert pressure, fixation or reduction of the bone or to place prosthetic joints or other implants.", "Other medical procedures can require access to bone.", "For example, the interosseous canal of bone can be accessed to allow fluid administration.", "Bone can also be accessed to allow the harvesting of bone, collection of bone marrow cores, or for the aspiration of bone marrow for diagnostic or therapeutic purposes.", "During any procedure where a drill or other driver is used to advance a tool into and through bone, the user must consciously and carefully limit the penetration to the desired depth.", "If the user allows the tool to penetrate further, the patient can suffer injury to distal structures such as nerve, brain, spinal cord, artery, vein, muscle, fascia, bone or joint space structures.", "These types of injuries can lead to severe patient morbidity and even death.", "The devices inserted to a drilled bore often must fit within a narrow length range that can vary sometimes by no more than a millimeter or less.", "Once the drilling of a bone is safely complete, it is often prudent to obtain the depth of the bore made by the drilling tool.", "Many procedures require knowledge of the depth of tool penetration, such as in the placement of internal fixation devices, screws and other implantable hardware.", "Selecting an appropriate length of the screw or other implant necessary for the procedure depends upon such knowledge of the bore's depth.", "Conventional techniques used in the art are often inconvenient, time consuming and unreliable often requiring trial and error and multiple exposures to radiographs before the proper implant insertion is achieved.", "A common way to obtain the depth of the bore formed by a drilling tool is to use a depth gauge.", "Often users must interrupt the drilling procedure in order to palpate or measure with a depth gauge whether or not the desired depth has been achieved.", "In many instances a user will take a radiograph during a drilling procedure to confirm the appropriate depth of penetration has been achieved or take a radiograph while the depth gauge is in place to ensure the information the gauge provides is accurate.", "Depth gauges used in the art can be inaccurate resulting in a user placing a screw of an inappropriate length not often identified until a confirming radiograph is taken.", "Each radiograph taken increases the radiation exposure of the surgeon, staff and patient in the operating suite.", "Depth gauges known in the art can also break and require the user to retrieve it from the bore.", "Inconvenient and inaccurate depth measurement devices and methods can result in improperly sized screws that must be removed and replaced with new properly sized screws.", "Wasted hardware, increased disruptions and delays in orthopedic procedures ultimately increase the expense of a procedure as well as expose the surgeon, staff and the patient to unnecessary radiation.", "The cost of the additional time, the wasted hardware and the radiation exposure are quite significant." ], [ "<SOH> SUMMARY <EOH>The techniques known in the art to drill holes in bone are technically demanding and require separate measuring steps that interrupt the actual drilling of the bone adding time, cost and the need for additional confirming radiographs to complete such procedures.", "There remains a need for safer, controlled drilling methods and devices.", "There is also a need for an instrument that simultaneously controls and measures the depth of penetration of the instrument during procedures such as placement of internal fixation devices, screws, and other implantable hardware.", "In one aspect, disclosed is a medical driving device including a housing having a proximal end and a distal end.", "The housing includes a hand-held portion near the proximal end of the housing; and an engagement portion near the distal end of the housing; a first drive shaft extending through a region of the housing between the proximal and distal ends; a first drive element coupled to a region of the first drive shaft; a second drive element coupled to the first drive shaft and to a second drive shaft; a coupler coupled to the second drive element, the coupler interchangeably connected to a working tool; and a tool guide assembly.", "The tool guide assembly includes a tool guide surrounding the working tool; a forward surface guide having a proximal region and a distal region, the distal region configured to couple to the tool guide; and a rear surface guide configured to couple to the first drive shaft and the proximal region of the forward surface guide.", "The device further includes a programmable electronics package configured to sense torque in at least the second drive element.", "The first drive shaft and the second drive shaft can be in a co-axial arrangement, parallel arrangement, or an orthogonal co-axial arrangement relative to one another.", "The hand-held portion further can include an actuator.", "The second drive element coupled to the second drive shaft can drive the coupler and the working tool.", "The coupler and the working tool can be rotated by the second drive shaft.", "The coupler and the working tool can be oscillated by the second drive shaft.", "The tool guide assembly can travel axially towards the proximal end of the housing to a retracted state upon actuation of the first drive shaft.", "Axial travel of the tool guide towards the proximal end of the housing can reveal a length of the working tool that extends beyond the tool guide.", "The working tool can be a drill bit, a detuned drill bit, wire, Kirschner wire, pin, trochar, burr, screwdriver, reamer, saw, saw blade, router, router bit, stepped drill bit, bone plug removal tool, bone harvesting tool, bone marrow harvesting tool, and bone marrow aspirating tool.", "The programmable electronics package can measure current used to drive the second drive element.", "The current measured can correspond to a torque of the working tool and the material strength and density of work penetrated.", "The device can further include a torque sensor positioned on the housing between the second drive element and the working tool, the torque sensor configured to directly measure torque of the working tool.", "The torque sensor can be configured to communicate measurements of torque to the programmable electronics package.", "A change in the measurements of torque can correspond to change in material strength and density of work penetrated.", "The device can further include an alert such that the torque sensor communicates with the programmable electronics package in real-time and the alert provides a user with information regarding status of the driving device during use.", "The alert can be an auditory, visual or tactile signal.", "The work penetrated can be medullary canal, cancellous bone, cortical bone, or soft tissue.", "The device can further include one or more axial force sensors configured to sense the axial force applied at one or both of the distal end of the tool guide and the working tool.", "The device can further include an axial force alert, the axial force sensor communicates with the programmable electronics package in real-time and the axial force alert provides a user with information regarding status of the driving device during use.", "The axial force alert can be an auditory, visual or tactile signal.", "The visual signal can be one or more LEDs positioned within a user line-of-sight, wherein the LEDs indicate degree of axial pressure being applied by the user in real-time.", "The proximal region of the forward surface guide can be telescopically coupled to the rear surface guide.", "The device can further include a gearbox connecting the second drive element to the working tool.", "The tool guide surrounding the working tool can be configured to assist in the engagement of an implant.", "The tool guide can include one or more features that mechanically couple with corresponding features of the implant.", "The implant can be a fracture fixation plate or a joint part.", "The tool guide can couple to the implant at an angle away from perpendicular.", "In another aspect, disclosed is a method of penetrating bone using a driving instrument including contacting a field of bone with a distal engagement end of the instrument; receiving a first input by a first drive element of the instrument, the first drive element coupled to a working tool; driving the working tool at a first speed; receiving a second input by a second drive element of the instrument, the second drive element coupled to a guide surrounding at least a portion of the distal engagement end of the instrument; moving the guide axially in a proximal direction; and revealing a length of the working tool extending beyond the distal engagement end of the instrument.", "The length of the working tool extending beyond the distal engagement end of the instrument can correspond to a depth of penetration by the working tool into the field of bone.", "The method can further include receiving commands by the instrument to electronically program the depth of penetration by the working tool.", "The method can further include instantaneously measuring axial motion of the guide using a transducer coupled to the instrument.", "The method can further include adjusting axial movement of the guide to avoid plunge of the working tool.", "The method can further include adjusting movement of the working tool to avoid tissue damage.", "The method can further include alerting a user of a change in axial force against the field of bone using a signal, wherein the signal comprises an auditory, visual or tactile signal.", "The method can further include instantaneously measuring torque of the working tool.", "The torque can be measured electronically.", "The torque can be measured directly using a torque sensor in contact with at least a portion of the second drive element.", "The torque can correspond to a material strength and density of the field of bone.", "The method can further include alerting a user of a change in material strength and density of the field of bone using a signal, wherein the signal comprises an auditory, visual or tactile signal.", "A change in torque measured can indicate a transition from a first tissue type to a second tissue type.", "The first tissue type can include cortical bone and the second tissue type can include medullary canal or cancellous bone.", "The first tissue type can include medullary canal or cancellous bone and the second tissue type can include cortical bone.", "Other features and advantages will be apparent from the following description of various embodiments, which illustrate, by way of example, the principles of the disclosed devices and methods." ], [ "REFERENCE TO PRIORITY DOCUMENTS This application is a continuation of U.S. application Ser.", "No.", "14/522,087 filed Nov. 24, 2014, which is a continuation application of U.S. application Ser.", "No.", "13/077,794 filed Mar.", "31, 2011, which claims the benefit of priority to U.S.", "Provisional Patent Application Ser.", "No.", "61/319,771, filed on Mar.", "31, 2010; and U.S.", "Provisional Patent Application Ser.", "No.", "61/333,685, filed on May 11, 2010; and U.S.", "Provisional Patent Application Ser.", "No.", "61/421,596, filed on Dec. 9, 2010.Priority of the filing dates and the disclosures of the Patent Applications are hereby incorporated by reference in their entirety.", "BACKGROUND Orthopedic surgery can require bone drilling for the repair of fractures or insertion of implants or other devices.", "The resulting holes can be used to accept screws, implants and other devices to exert pressure, fixation or reduction of the bone or to place prosthetic joints or other implants.", "Other medical procedures can require access to bone.", "For example, the interosseous canal of bone can be accessed to allow fluid administration.", "Bone can also be accessed to allow the harvesting of bone, collection of bone marrow cores, or for the aspiration of bone marrow for diagnostic or therapeutic purposes.", "During any procedure where a drill or other driver is used to advance a tool into and through bone, the user must consciously and carefully limit the penetration to the desired depth.", "If the user allows the tool to penetrate further, the patient can suffer injury to distal structures such as nerve, brain, spinal cord, artery, vein, muscle, fascia, bone or joint space structures.", "These types of injuries can lead to severe patient morbidity and even death.", "The devices inserted to a drilled bore often must fit within a narrow length range that can vary sometimes by no more than a millimeter or less.", "Once the drilling of a bone is safely complete, it is often prudent to obtain the depth of the bore made by the drilling tool.", "Many procedures require knowledge of the depth of tool penetration, such as in the placement of internal fixation devices, screws and other implantable hardware.", "Selecting an appropriate length of the screw or other implant necessary for the procedure depends upon such knowledge of the bore's depth.", "Conventional techniques used in the art are often inconvenient, time consuming and unreliable often requiring trial and error and multiple exposures to radiographs before the proper implant insertion is achieved.", "A common way to obtain the depth of the bore formed by a drilling tool is to use a depth gauge.", "Often users must interrupt the drilling procedure in order to palpate or measure with a depth gauge whether or not the desired depth has been achieved.", "In many instances a user will take a radiograph during a drilling procedure to confirm the appropriate depth of penetration has been achieved or take a radiograph while the depth gauge is in place to ensure the information the gauge provides is accurate.", "Depth gauges used in the art can be inaccurate resulting in a user placing a screw of an inappropriate length not often identified until a confirming radiograph is taken.", "Each radiograph taken increases the radiation exposure of the surgeon, staff and patient in the operating suite.", "Depth gauges known in the art can also break and require the user to retrieve it from the bore.", "Inconvenient and inaccurate depth measurement devices and methods can result in improperly sized screws that must be removed and replaced with new properly sized screws.", "Wasted hardware, increased disruptions and delays in orthopedic procedures ultimately increase the expense of a procedure as well as expose the surgeon, staff and the patient to unnecessary radiation.", "The cost of the additional time, the wasted hardware and the radiation exposure are quite significant.", "SUMMARY The techniques known in the art to drill holes in bone are technically demanding and require separate measuring steps that interrupt the actual drilling of the bone adding time, cost and the need for additional confirming radiographs to complete such procedures.", "There remains a need for safer, controlled drilling methods and devices.", "There is also a need for an instrument that simultaneously controls and measures the depth of penetration of the instrument during procedures such as placement of internal fixation devices, screws, and other implantable hardware.", "In one aspect, disclosed is a medical driving device including a housing having a proximal end and a distal end.", "The housing includes a hand-held portion near the proximal end of the housing; and an engagement portion near the distal end of the housing; a first drive shaft extending through a region of the housing between the proximal and distal ends; a first drive element coupled to a region of the first drive shaft; a second drive element coupled to the first drive shaft and to a second drive shaft; a coupler coupled to the second drive element, the coupler interchangeably connected to a working tool; and a tool guide assembly.", "The tool guide assembly includes a tool guide surrounding the working tool; a forward surface guide having a proximal region and a distal region, the distal region configured to couple to the tool guide; and a rear surface guide configured to couple to the first drive shaft and the proximal region of the forward surface guide.", "The device further includes a programmable electronics package configured to sense torque in at least the second drive element.", "The first drive shaft and the second drive shaft can be in a co-axial arrangement, parallel arrangement, or an orthogonal co-axial arrangement relative to one another.", "The hand-held portion further can include an actuator.", "The second drive element coupled to the second drive shaft can drive the coupler and the working tool.", "The coupler and the working tool can be rotated by the second drive shaft.", "The coupler and the working tool can be oscillated by the second drive shaft.", "The tool guide assembly can travel axially towards the proximal end of the housing to a retracted state upon actuation of the first drive shaft.", "Axial travel of the tool guide towards the proximal end of the housing can reveal a length of the working tool that extends beyond the tool guide.", "The working tool can be a drill bit, a detuned drill bit, wire, Kirschner wire, pin, trochar, burr, screwdriver, reamer, saw, saw blade, router, router bit, stepped drill bit, bone plug removal tool, bone harvesting tool, bone marrow harvesting tool, and bone marrow aspirating tool.", "The programmable electronics package can measure current used to drive the second drive element.", "The current measured can correspond to a torque of the working tool and the material strength and density of work penetrated.", "The device can further include a torque sensor positioned on the housing between the second drive element and the working tool, the torque sensor configured to directly measure torque of the working tool.", "The torque sensor can be configured to communicate measurements of torque to the programmable electronics package.", "A change in the measurements of torque can correspond to change in material strength and density of work penetrated.", "The device can further include an alert such that the torque sensor communicates with the programmable electronics package in real-time and the alert provides a user with information regarding status of the driving device during use.", "The alert can be an auditory, visual or tactile signal.", "The work penetrated can be medullary canal, cancellous bone, cortical bone, or soft tissue.", "The device can further include one or more axial force sensors configured to sense the axial force applied at one or both of the distal end of the tool guide and the working tool.", "The device can further include an axial force alert, the axial force sensor communicates with the programmable electronics package in real-time and the axial force alert provides a user with information regarding status of the driving device during use.", "The axial force alert can be an auditory, visual or tactile signal.", "The visual signal can be one or more LEDs positioned within a user line-of-sight, wherein the LEDs indicate degree of axial pressure being applied by the user in real-time.", "The proximal region of the forward surface guide can be telescopically coupled to the rear surface guide.", "The device can further include a gearbox connecting the second drive element to the working tool.", "The tool guide surrounding the working tool can be configured to assist in the engagement of an implant.", "The tool guide can include one or more features that mechanically couple with corresponding features of the implant.", "The implant can be a fracture fixation plate or a joint part.", "The tool guide can couple to the implant at an angle away from perpendicular.", "In another aspect, disclosed is a method of penetrating bone using a driving instrument including contacting a field of bone with a distal engagement end of the instrument; receiving a first input by a first drive element of the instrument, the first drive element coupled to a working tool; driving the working tool at a first speed; receiving a second input by a second drive element of the instrument, the second drive element coupled to a guide surrounding at least a portion of the distal engagement end of the instrument; moving the guide axially in a proximal direction; and revealing a length of the working tool extending beyond the distal engagement end of the instrument.", "The length of the working tool extending beyond the distal engagement end of the instrument can correspond to a depth of penetration by the working tool into the field of bone.", "The method can further include receiving commands by the instrument to electronically program the depth of penetration by the working tool.", "The method can further include instantaneously measuring axial motion of the guide using a transducer coupled to the instrument.", "The method can further include adjusting axial movement of the guide to avoid plunge of the working tool.", "The method can further include adjusting movement of the working tool to avoid tissue damage.", "The method can further include alerting a user of a change in axial force against the field of bone using a signal, wherein the signal comprises an auditory, visual or tactile signal.", "The method can further include instantaneously measuring torque of the working tool.", "The torque can be measured electronically.", "The torque can be measured directly using a torque sensor in contact with at least a portion of the second drive element.", "The torque can correspond to a material strength and density of the field of bone.", "The method can further include alerting a user of a change in material strength and density of the field of bone using a signal, wherein the signal comprises an auditory, visual or tactile signal.", "A change in torque measured can indicate a transition from a first tissue type to a second tissue type.", "The first tissue type can include cortical bone and the second tissue type can include medullary canal or cancellous bone.", "The first tissue type can include medullary canal or cancellous bone and the second tissue type can include cortical bone.", "Other features and advantages will be apparent from the following description of various embodiments, which illustrate, by way of example, the principles of the disclosed devices and methods.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a perspective, cut-away view of one embodiment of an instrument.", "FIG.", "2 is a side, cut-away view of the instrument of FIG.", "1.FIG.", "3 is a perspective view of another embodiment of an instrument.", "FIG.", "4 is a perspective view of the instrument of FIG.", "3 showing a length of the working tool in an extended position.", "FIG.", "5 is an exploded view of the instrument of FIG.", "3.FIG.", "6 is a perspective view of an instrument having a guide interfaced with a fracture fixation plate.", "FIG.", "7 is a perspective view of the guide of FIG.", "6 interfaced with the fracture fixation plate.", "FIG.", "8 is a perspective view of a guide/fixation plate interface system.", "FIG.", "9 is a perspective view of a guide coupled to the instrument of FIG.", "6 interfaced with the fracture fixation plate.", "FIG.", "10 is a side view of a drill bit having detuned flutes.", "FIGS.", "11A and 11B are perspective views of an instrument having a saw blade and saw blade guide coupled thereto.", "FIG.", "12 is a side view of an instrument having a driving tool coupled thereto.", "FIG.", "13 is a perspective view of another embodiment of an instrument.", "FIG.", "14 is a perspective view of a rotary encoder for use with an instrument described herein.", "FIG.", "15 is a schematic view of a drive mechanism showing torque forces generated by a working tool, gearbox and motor.", "FIG.", "16 is a schematic view of a direct torque sensor measuring force produced by drilling torque.", "DETAILED DESCRIPTION This disclosure relates to a surgical instrument for preparing a bore in animal tissue.", "In an embodiment, the disclosure relates to a surgical instrument that drives a tool in which both drive power and relative axial extension of the tool are controlled and measurable.", "The instrument can have both a rotational drive and an axial drive, each of which can be controllable by the user.", "The instrument allows a user to control and simultaneously measure the travel of the tool into a target tissue.", "FIGS.", "1-2 illustrate cut-away views of an instrument 10.The instrument 10 can include a body 20 that houses two drive motors 30, 60 and a working tool 110 coupled via a chuck 90 extendable near a distal engagement end 120 of the instrument 10.As will be described in more detail below, the instrument 10 can instantaneously sense, meter and control the work created by the tool 110.Instantaneous sensing, metering and controlling the instrument 10 help to prevent injury to surrounding tissues and structures that could otherwise be caused by the tool 110.For example, sensing, metering and controlling the rotational speed of the drive can reduce the risk of heating surrounding tissue and bone, for example to the point of causing localized burns.", "Sensing, metering and controlling the axial motion and/or relative extension of the working tool 110 can prevent penetrating injuries, for example, to structures distal of the target such as nerve, brain, spinal cord, artery, vein, muscle, fascia, bone or joint space structures.", "Instantaneous sensing, metering and controlling the bore created as the working tool penetrates the tissue can provide an advantage when selecting implants for insertion.", "For example, the length of the drilling hole and subsequently the length of the implant needed can be simultaneously metered upon creating the bore.", "This eliminates the need for an additional step of measuring the depth of the bore created with a separate device.", "Further, depth gauges can frequently provide false measurements resulting in users selecting the wrong size implant for insertion and requiring them to remove the implant and reinsert a different sized implant.", "Conventional depth gauges are also prone to breakage, which can lead to additional time usage and patient morbidity.", "Sensing, metering and controlling the depth of the bore in real-time or as it is being created eliminates the trial-and-error process of selecting the correct implant for the procedure, which ultimately can improve patient safety.", "The instruments described herein also save operating time and the need for additional procedures like repeated radiographs in determining implant size.", "Because estimates of operating room costs for the personnel alone can be as high as $25 per minute even small savings of time in an operating room can result in large savings of money.", "The instruments described herein provide an added benefit of reducing the number of radiographs needed in the operating room.", "Intra-operative radiographs and radiation exposure are one of the major occupational risks to surgeons and operating room staff.", "Radiation exposure of this type has been shown to lead to radiation dermatitis, cataracts, skin cancers, leukemia and other cancers.", "The instruments and methods described herein reduce the number of radiographs needed per procedure and the life-time exposure of surgeons and staff to x-rays.", "This reduced radiation exposure ultimately lowers chronic radiation exposure and the risk of radiation-related illnesses in surgeons and their staff.", "Drive System The configuration of the drive system of the instrument 10 can vary.", "In an embodiment shown in FIGS.", "1-2, drive motor 30 of the instrument 10 can be a fixed axial drive motor 30 and drive motor 60 can be a slidable, rotational drive motor 60.Drive motor 30 can be coupled to a drive shaft 40, which can in turn be coupled to drive motor 60.The drive shaft 40 can be a jack screw, ball screw, lead screw and the like that can translate the torque or rotary movement of the drive motor 30 into thrust in an axial direction to slidably move the drive motor 60 relative to the instrument 10.The drive shaft 40 can be made to move either in a distal (forward) direction or a proximal (reverse) direction that is substantially parallel to the axis of the instrument 10.The drive motor 60 can connect to the drive shaft 40 by way of a detachable coupler 50.The drive motor 60 can be coupled to and rotate a drive shaft 80 that can connect to the chuck 90 that holds the working tool 110.As such, movement of the drive motor 60 along the longitudinal axis of the instrument 10 can cause similar movement of the working tool 110 and extension of the tool 110, for example beyond the distal engagement end 120 of the instrument 10.In use, the drive shaft 40 driven by drive motor 30 can axially drive the drive motor 60, which can rotate the drive shaft 80, which can rotate the chuck 90 which can rotate the tool 110.The chuck 90 can be stabilized within the body 20, for example by bearings 100.The bearings 100 can be axially slidable and stabilizing.", "The second drive motor 60 can be constrained or held rotationally still to provide for the eventual rotational movement of the working tool 110.The drive motor 60 can be fixed against rotational movement by guide rails or anti-rotation conducting flanges 70.In an embodiment, the flanges 70 slide within channels in the body 20.In an embodiment, each channel can have an opposite polarity such that they conduct electricity from a power source to the drive motor 60.In another embodiment, the power can be separate from the conducting flanges 70.The anti-rotation conduction flanges 70 can also be spiral shaped and travel through spiral grooves to add stability.", "The anti-rotation conduction flanges can also be excluded from the device and the rotational drive motor fixed to the axial drive shaft 40 causing the drive motor 60 to turn along with the axial drive shaft 40.It should be appreciated that the configuration of the drive shaft 40, 80 relative to the drive motors 30, 60 can vary.", "For example, the motors 30, 60 can be in parallel overlapping orientation relative to one another as shown in FIGS.", "1 and 2.Alternatively, the drive shaft 40 and motor 30 can be positioned in a co-axial orientation as shown in FIGS.", "3, 4 and 5.In another example, the drive shaft 40 and motor 30 can be positioned orthogonal to drive shaft 80 and motor 60.For example, the rotated motor can be positioned within the handle 25 of the instrument 10.The parallel overlapping orientation as well as the orthogonal orientation can provide for a shorter, more compact length of the instrument 10 without limiting the overall extension of the tool 110 that can be achieved.", "Alternatively, the drive shaft 40, 80 and motor 30, 60 can be connected via a gearbox (not shown).", "It should also be appreciated that use of the term “working tool” herein or “rotation of the working tool” is not intended to be limiting and that working tools other than rotating drill bits are considered as will be described in more detail below.", "Although the embodiments shown herein use motors, such as a stepper motor powered by a battery, it should be appreciated that power systems other than rotational drive motors are considered.", "For example, a non-electric drive motor, pneumatic motors or actuators powered for example by a nitrogen gas source, electrical motors, hydraulic actuators, and the like or a combination thereof can be incorporated into the instrument.", "It should also be appreciated that a motor and gearing can be used in place of the two-motor embodiment.", "Instrument Guides Extension of the working tool 110 relative to the longitudinal axis of the instrument 10 can be accomplished as described above via linear movement of the drive motor 60 within the body 20 of the instrument 10.In another embodiment, the drive motor 60 need not move axially relative to the instrument 10.Instead, extension of the working tool 110 relative to the distal engagement end 120 of the instrument 10 can be effected by the movement of one or more surface guides on the instrument 10 as will be described below.", "FIGS.", "3-5 illustrate an embodiment of an instrument 10 that includes a body 20 that houses an axial drive motor 30, a rotational drive motor 60, a working tool 110 coupled via a chuck 90 extendable near a distal engagement end 120 of the instrument 10.A chuck extension 280 can also be included.", "The instrument 10 can further include a rear surface guide 300 and a forward surface 302 guide that, as will be discussed in more detail below, can be withdrawn in a proximal direction to reveal a length of the working tool 110 extending beyond the distal engagement end 120 of the instrument 10.The drive motor 30 can be an axial drive motor and spindle seated near the proximal end (rear) of the body 20 and the second drive motor 60 can be a rotational drive motor and spindle seated near the distal (front) end of the body 20.Body insert 220 can fit inside the top of the body 20 such that the body insert 220 covers the drive motors 30, 60 (see FIG.", "5).", "The drive motor 30 can attach to drive a drive shaft 40 and the drive shaft 40 can attach to the drive lug 240.The drive lug 240 can attach to the rear surface guide 300 at its proximal end.", "The distal end of the rear surface guide 300 can attach to the proximal end of the forward surface guide 302.There can be one or more o-rings 250 between the two surface guides 300, 302.The drive lug 240 and the rear surface guide 300 can sit in the body 20 above the body insert 220.The top of the body 20 also can accept a body cover 214.The rear surface guide 300 can fit between the body 20 and the body cover 214 such that it is free to move within the body 20 and extend beyond the body 20 and the body cover 214.As best shown in FIG.", "3, the forward surface guide 302 can engage an outer surface of the chuck 90, for example, via a sleeve and/or one or more stabilizing flanges 305.In another embodiment, the chuck 90 can function without a sleeve or stabilizing flanges and instead the forward surface guide 302 can have a bushing or other device to engage the chuck 90 directly and still allow the chuck 90 to spin freely.", "In use, the axial drive motor 30 can power the drive lug 240 in an axial direction, which in turn can drive in an axial direction the rear surface guide 300 coupled to the forward surface guide 302.An increased length of the working tool 110 is revealed in order to engage the work.", "The drive motor 60 rotates the chuck 90 and the working tool 110.The surface guides 300, 302 shown in the drawings have two “arms” or supports that extend axially.", "But it should be appreciated that the surface guides 300, 302 can have one, two, three or more arms that provide additional support to bear the load.", "It should also be appreciated that the surface guides 300, 302 can be a single unit.", "In another embodiment, the surface guides 300, 302 can be telescoping surface guides.", "This can provide the instrument 10 with a larger range in overall drill length in a more efficient configuration.", "The telescoping surface guides can each include an actuator such as a pneumatic, hydraulic, motorized or other actuator that causes the surface guides 300, 302 to telescope and change overall guide length (i.e.", "telescope outward to lengthen or telescope inward to shorten).", "In another embodiment, the telescoping surface guides 300, 302 can be used to achieve depth control without the use of an axial motor.", "The axial electric motor can be replaced by a hydraulic or pneumatic motor, as can the rotational motor.", "A distal guide 170 can optionally be coupled to the instrument 10.In one embodiment, the distal guide 170 is coupled to a distal end of the body 20 of the instrument 10 (as shown in FIGS.", "1 and 2).", "In another embodiment, the distal guide 170 is coupled to the forward surface guide 302 (as shown in FIGS.", "3-5).", "The distal guide 170 can include a central channel through which the working tool 110 can extend to engage the work.", "The distal guide 170 can have a tapered geometry or reduced outer diameter such that its contact surface is relatively small compared to the distal end of the body 20 and the bulk of the instrument 10 is focused into a small area of contact with the work.", "The distal guide 170 can also include gripping features at its forward surface such as spikes or other protrusions such that the guide 170 can hold its position on the work.", "The distal guide 170 can assist in the engagement of bone, fracture plates or other implants or joint parts.", "One or more portions of the distal guide 170 can couple with the implant, for example by directly pressing or screwing the implant onto one or more corresponding features of the distal guide 170.FIGS.", "6-9 show an instrument and various embodiments of distal guides 170a, 170b, 170c that can interface with the work using various mechanisms.", "Guide 170a can engage an implant 815, such as a fracture fixation plate, by a threaded interface, or by another mechanism, such that the guide 170a screws into, or otherwise couples with the implant 815.Guides 170a and 170b are shown connected to the implant 815 in a generally perpendicular configuration.", "Alternatively, distal guide 170c can connect to the implant 815 at an angle away from perpendicular.", "The guide 170b can include an interface that provides a unique connection with the implant 815.For example, the distal guide 170b can include a pin-index type connection or a diameter-index type system that provide non-interchangeable connections between the distal guide 170 and the implant 815.As such, a specific implant 815 can interface with a particular distal guide 170 to prevent misconnections.", "The specific geometry of the interface between the distal guide 170 and the implant 815 can vary.", "FIG.", "8 shows a schematic of just one example of an interface system between the implant 815 and the distal guide 170.The distal guide 170 can include one or more geometric features 805 that extend from a forward surface of the distal guide 170.The geometric features 805 can couple with corresponding geometric features 810 provided on the implant 815 such that the two properly and uniquely interconnect.", "The corresponding geometric features 805, 810 can dictate the type of implant 815 that can be used with a particular distal guide 170 providing for a unique pairing between the two.", "It should be appreciated that although the figure shows the implant 815 as a fracture fixation plate, the implant 815 with which the guide 170 can interface can vary including bone, fracture plates or other implants or joint parts.", "The interface between the distal guide 170 and the implant 815 can provide for directional guidance for the working tool 110.The implant 815 can connect to the distal guide 170, the distal guide 170 can connect to the instrument 10 resulting in one interconnected complex for drilling a bore.", "In one embodiment, the implant 815 couples to the distal guide 170 which can be attached to the instrument 10 via the forward surface guide 302.The implant 815 can also couple a distal guide 170 that is separate from the instrument 10.In another embodiment shown in FIG.", "9, the instrument can include two guides.", "In this embodiment, a first distal guide 170 is attached to the instrument 10 and a second distal guide 170a is connected to the implant 815.The first distal guide 170 can then couple to the second distal guide 170a.", "Working Tools As mentioned above, the working tool 110 can be connected to the instrument 10 using a rotatably-driven coupler or chuck 90 with or without a chuck extension 280.The chuck 90 can be a conventional coupler such as a three-jaw chuck in which the jaws grasp the proximal portion of the tool 110 and hold it firmly in place.", "The chuck 90 can be actuated to open or close the jaws by a rotation mechanism or a key or other techniques known in the art.", "The chuck 90 can also be a quick-release type of coupler.", "The chuck 90 can be extended beyond the distal engagement end 120 such that the chuck 90 can be accessed external of the body 20.This accessibility of the chuck 90 relative to the instrument 10 allows for a user to make reliable connections between the working tool 110 and the chuck 90.The exterior access can also allow for shorter, safer driven tools than if the chuck 90 was internal to the instrument body 20.Additionally, the exterior access can provide for ease of cleaning this portion of the instrument 10.The working tool 110 as described herein can include, but is not limited to, tools such as a drill bit, Kirschner (or other) wire, pin, trochar, burr, screwdriver, reamer, saw, saw blade, router, router bit, stepped drill bit, bone plug removal tools, bone harvesting tools, bone marrow harvesting tools, bone marrow aspirating tools or any other tools that can be reversibly attached to a chuck 90 or other type of coupling device.", "It should be appreciated that where a working tool is described herein as a drill bit or wire or pin or other type of tool that such description is not intended to be limiting.", "It should be appreciated that a wide variety of tools can be used as the working tool with the instruments described herein.", "For example, the working tool can be a saw blade connected to a coupler that oscillates or reciprocates the saw blade as described with respect to FIGS.", "11A-11B below or a wire driver as described with respect to FIG.", "12 below.", "The working tool 110 can be made of metal materials such as titanium metal or stainless steel that can be sterilized and reused.", "Alternatively, the working tool 110 can be made of polymeric material that can be discarded after each use.", "The material can be chosen to provide the necessary strength to allow the proper tool action.", "FIG.", "10 shows an embodiment of a drill bit 905 having a flute 910 that is detuned or dulled.", "It should be appreciated that the entire length of the flute 910 need not have the same edge geometry.", "For example, the detuned flute 910 can have an edge 915 that is sharper starting at a proximal region of the bit 905 towards the tool attachment region.", "It should also be appreciated that the bit 905 can have more than one flute 910 as is known in the art.", "The detuned flute 910 allows for greater sensitivity in measurement of torque and measurement of current.", "The bit 905 can also have fast spirals 920 with short rotational diameter and a short tip 925 such that it transfers less energy to the work to avoid over-heating the work and surrounding tissues.", "The drill bit 905 design also can provide a feel to the user such that information regarding the subtle material strength and density changes of the work can be appreciated during use.", "Other Tool Embodiments It should be appreciated that other medical devices can incorporate the metering and controlling features of the instruments as described herein.", "FIGS.", "11A and 11B show an embodiment of an instrument 1005 having a working tool that is an oscillating bone saw blade 1010 coupled to chuck 1090 and surrounded by a saw blade guide 1007 that is coupled to a forward surface guide 1002 coupled to a rear surface guide 1000.The oscillating saw blade 1010 can have opposed proximal and distal ends and can be formed so that teeth 1015 extend forward from the distal end of the planar body of the blade 1010.The arrangement and geometry of the teeth 1015 can vary.", "The body of the blade 1010 can be formed of material such as stainless steel or other appropriate cutting material.", "The teeth 1015 can extend forward from the blade distal end through an elongate slot 1008 in the saw blade guide 1007 coupled to the instrument as best shown in FIG.", "11B.", "The proximal end of the blade 1010 can include features (not shown) that facilitate the coupling of the blade 1010 to a chuck 1090.The chuck 1090 can connect to a drive mechanism that oscillates or reciprocates the saw blade 1010 to effect cutting.", "For example, the distal end of the blade 1010 can pivot back and forth relative to the proximal end of the blade 1010.As the saw blade 1010 saws through material, another drive mechanism can drive the rear surface guide 1000, the forward surface guide 1002 and the saw blade guide 1007 in an axial direction such that the body of the blade 1010 extends further through the slot 1008 of the saw blade guide 1007.The slot 1008 and the guides 1000, 1002, 1007 are configured such that they do not interfere with the oscillating and/or reciprocating motion of the blade 1010.The length of the blade 1010 can vary to accommodate various depth penetrations.", "FIG.", "12 shows an embodiment of an instrument 1105 having a working tool used to implant a Kirschner wire (k-wire) or other wire or pin.", "In an embodiment, the instrument 1105 can incorporate a wire driver 1110 used to implant a k-wire 1115 (or other wire or pin, hereinafter called “wire” for simplicity).", "The wire driver 1110 can be a modular attachment that can be used with the various instruments described herein.", "For example, the wire driver 1110 can be inserted into other instruments 10 described herein and used in place of the chuck 90, which can be removable.", "Alternatively, the wire driver instrument 1105 can be completely separate embodiments in which the wire driver 1110 is not modular or removable and instead is coupled permanently to the instrument 1105.It should be appreciated that the various instruments described herein can be modular such that mechanical features such as the chuck 90 or the axial drive motor 30 can be swapped out in place for one another.", "The wire driver 1110 can hold the wire 1115 as well as rotate or oscillate the wire 1115.The wire driver 1110 can be released to slide axially to a new position causing more (or less) wire 1115 to be exposed for allowing a further penetration of the bone.", "In an embodiment, the body 1120 of the driver 1105 including the internal workings are cannulated such that the wire 1115 can be fed through the driver 1105 body 1120.The wire 1115 can extend through the cannulation in the body 1120 of the driver 1105 from the front of the driver 1105 out through the back end 1125 of the driver 1105.As mentioned, the wire driver 1110 can hold the wire 1115 in place much like a drill chuck.", "When the wire driver 1110 is activated, the rotational motor (not shown) can oscillate or rotate the wire 1115 in a clockwise or counter-clockwise direction.", "As with previous embodiments, the rotational motor can be biased in either rotational direction.", "When the driver 1105 is activated the axial drive (not shown) can pull the surface guide(s) 1130 back (proximally) and the wire 1115 can advance into the work site such as bone.", "A trigger 1135 can be incorporated into the driver 1105 that holds the wire 1115 when grasped by a user.", "If pressure on the trigger 1135 is released, the trigger 1135 releases the wire 1115 such that the driver 1105 can slide forward or backward to expose less or more wire 1115, respectively.", "When a user desires more wire 1115, the trigger 1135 can be released and the driver 1105 pushes the surface guide 1130 forward.", "The length the surface guide 1130 moves forward equals the length of wire 1115 that is now available for advancement into the bone.", "This length can be added to the computed total axial distance as needed to obtain an accurate account of the length of wire 1115 that was driven into the bone.", "The wire 1115 can be held in place by either the guide 1130 (such as by pinching) or the bone into which the wire 1115 was driven can itself be used to hold the wire 1115 in place.", "If the wire 1115 is held in place by the bone, the user can urge the guide 1130 against the bone as the surface guide 1130 pushes the driver 1105 back to let out more wire 1115.If the user desires to remove the wire 1115 from the bone, the reverse axial drive (not shown) can be engaged such that the surface guide 1130 move forward and the driver 1105 moves backward away from patient while the trigger 1135 is engaged.", "It should also be appreciated that, although not shown, this instrument embodiment can incorporate a distal guide 170 coupled to a forward end of the surface guide 1130 as described in previous embodiments.", "Tool Actuation Actuation of the drive motors and other features of the instruments described herein can vary.", "Actuators can include triggers, buttons and switches that can be retracted, pressed, squeezed, slid or otherwise actuated to perform a certain function of the instrument 10.The actuators can be incorporated into a handle of the instrument 10 in such a way that is ergonomically comfortable for a user.", "For example, the instrument can include a pistol grip having trigger-type actuators such that the instrument 10 can be easily and comfortably held and actuated during use.", "It should be appreciated, however, that the instrument 10 can have other configurations such as a straight-bodied instruments that do not include a pistol grip.", "Each drive motor can have a separate actuator for activation.", "For example, the drive motor 30 can be turned on by actuator 32 and the drive motor 60 can be turned on by actuator 62 (see FIG.", "1).", "The actuators 32, 62 can be depressible triggers positioned on a handle 25 of the body 20, such as within a trigger housing 212.The actuators 32, 62 can adjust the speed of the drive motors 30, 60 in a manner that is proportional to the degree of depression of the actuators 32, 62, for example relative to the instrument handle 25.The direction the drive shaft 40 moves can be changed from a forward to a reverse direction, for example, by the position of a switch or other selectable mechanism.", "Similarly, the drive motor 60 can be made to move in a forward or reverse direction as determined by the position of a selectable switch.", "Further, the motor can be biased in either rotational direction.", "In another embodiment shown in FIGS.", "3-5, the instrument 10 can include a forward trigger 232 and a reverse trigger 234 that can each actuate both drive motors 30, 60.The forward trigger 232 can be a two-stage forward trigger 232 such that it can engage the rotational drive motor 60 in the first stage (i.e.", "effecting working tool 110 rotation) and the axial drive motor 30 in the second stage (i.e.", "effecting working tool 110 extension).", "The speed of the rotational drive motor 60 can be proportional to the degree of actuation of the first stage of the forward trigger 232, for example depression of the trigger 232.The speed of the axial drive motor 30 can be proportional to the degree of actuation of the second stage of the forward trigger 232.In an embodiment, the trigger 232 in the first stage can engage the rotational drive motor 60.The tool 110 spins and with further depression of the trigger 232 can reach full speed.", "Just before the trigger 232 enters the second stage, the axial drive motor 30 can engage.", "The axial drive motor 30 can cause withdrawal of the surface guides 300, 302 in a proximal direction P (see FIG.", "4) to reveal a length of the working tool 110 allowing it to engage with and bore into the work as the user applies pressure to the instrument 10 and keeps it engaged with the work.", "It should be appreciated that the axial drive motor 30 can also cause the movement of the working tool 110 in a distal direction to reveal the length as described with respect to other embodiments herein.", "It should be appreciated that an axial force sensor can be incorporated that assists a user in keeping the instrument engaged with the work, as will be discussed in more detail below.", "The reverse trigger 234 can cause both of the drive motors 30, 60 to reverse their direction.", "When the reverse trigger 234 is engaged while the two-stage trigger 232 is actuated during the first stage, the rotational drive motor 60 as well as the chuck 90 and the working tool 110, can spin in a reverse direction.", "When the second stage of the forward trigger 232 is actuated, and the reverse trigger 234 is still engaged, the rotational drive motor 60 as well as the chuck 90 and the working tool 110, can spin at maximal speed in a reverse direction and the axial drive motor 30 can begin to spin proportional to the degree of actuation of the second stage of the forward trigger 232.The action of the axial drive motor 30 can cause the drive lug 240, the rear surface guide 300, the forward surface guide 302 and the guide 170 to move in the distal direction (i.e.", "towards the work in direction of Arrow D, see FIG.", "3).", "The axial movement of the guides 300, 302 can push the instrument 10 away from the work and draw the working tool 110 out of the work.", "In another embodiment, the motors 30, 60 can have independent reverse functions and can be controlled independently via independent actuators or triggers.", "The instrument 10 can also include an oscillation select switch 262 (see FIGS.", "3-5).", "The oscillating function can also be actuated by certain trigger combinations or an oscillation trigger.", "When the oscillation select switch 262 is in the “off” position, the instrument 10 can function as described above.", "When the oscillation select switch 262 is in the “on” position, the rotational drive motor 60 can oscillate in the appropriate direction when the triggers 232, 234 are actuated and the axial drive motor 30 function is not affected.", "If the forward trigger 232 is actuated, the instrument 10 can oscillate in the forward direction, i.e.", "the rotational drive motor 60 can oscillate forward but the axial drive motor 30 can cause the drive lug 240, the rear surface guide 300 the forward surface guide 302 and the guide 170 to move in a proximal direction as before.", "If the reverse and forward triggers 232, 234 are actuated, the instrument 10 can oscillate in the reverse direction, i.e.", "the rotational drive motor 60 oscillates in reverse but the axial drive motor 30 can cause the drive lug 240, the rear surface guide 300, the forward surface guide 302 and the guide 170 to move in the distal direction as before.", "The oscillation select switch 262 can affect the function of the rotational motor 60 not the axial drive motor 30.When selected it can cause the rotational motor 60 to oscillate.", "Irrigation System The instruments described herein can include an irrigation system.", "The irrigation system allows for the surgical field to be kept cool while the instrument 10 is in use and reduce the risk of tissue damage such as bone burning and bone death.", "The irrigation system can also reduce the risk of hardware failure, the need for re-operation, infection, limb loss and death.", "The irrigation system can include one or more irrigation nozzles 130 located at or near the engagement end 120 of the body 20.In one embodiment, the irrigation nozzles 130 spray fluid from the distal tip of the body 20.In another embodiment, the irrigation nozzles 130 can be routed internally through the working tool 110.The irrigation fluid can be sprayed through a channel running through the working tool 110 and exiting at a port near the distal end of the tool 110.In a further embodiment, the forward surface guide 302 can have one or more irrigation nozzles 130 (see FIGS.", "3-5).", "The irrigation nozzles 130 can also be coupled to the distal guide 170.The irrigation nozzles 130 can deliver irrigation fluid (i.e.", "a liquid or a gas) through irrigation tubing 340 (see FIGS.", "3-5) from a sterile fluid bag or other irrigation fluid source.", "In an embodiment, carbon dioxide gas can be used to irrigate the work to remove heat.", "The irrigation tubing 340 can be coupled to the instrument 10 via an irrigation port near a proximal end of the body 20.The irrigation tubing 340 can be angled downward to avoid crimping and for more efficient manipulation of the instrument 10 by the user.", "An external fluid pump or gravity can be used to pressurize the irrigation system.", "The irrigation system can be kept outside the sterile surgical field except, for example, the irrigation tubing 340 connected to the instrument 10.Such an arrangement can contribute to the engagement end 120 and the working tool 110 remaining relatively free from bulk or other awkward equipment enabling more accurate placement and easy use of the instrument 10 in the surgical field.", "The irrigation system of the instrument 10 can also include a suction mechanism at or near the surgical field.", "Suction can be applied through the irrigation nozzles 130 or can be applied through additional channels.", "The irrigation system can be controlled manually by the user such as with an irrigation actuator positioned, for example, on a handle 25 of the instrument 10 or by a foot pedal or other mechanism.", "The irrigation actuator can be a depressible trigger or button that can turn on or off the flow of irrigation fluid from the irrigation tube 340.The same actuator or another actuator can turn on or off the suction applied to the surgical field.", "The irrigation system can also be controlled automatically for example by one or more sensors near the work site communicating with an electronics package of the instrument to be described in more detail below.", "Automated irrigation is generally a desired option for users as it can effectively reduce drill bit temperature, bone temperature and the risk of bone burning.", "Modularity and Internal Access The body 20 of the instruments 10 described herein can include one or more removable covers that can be used to access one or more of the various internal components.", "Further, one or more of the internal components can be modular and can be completely separated from the body 20 of the instrument 10.This allows for interchanging parts as well as cleaning and sterilizing the components of the instrument 10.In one embodiment, the instrument 10 can have a cover 122 near the engagement end 120 that can be removed to access, clean or remove the coupler 90, bearings 100 and drive shaft 80 and any other internal components of the instrument 10.The drive motor 60 can extend to a region near the distal end of the body 20 and allow for the actuation and release of the coupler 50.For example, the release can be a depressible button 52 (see FIG.", "5) on a surface of the drive motor 60 that can allow a user to disconnect the drive motor 60 from the drive shaft 40 when the release is depressed to allow a user to remove the drive motor 60 from the body 20.In another embodiment shown in FIG.", "13, a body cover 1515 can enclose the rear surface guide (not shown) and at least a proximal portion of the forward surface guide 302.The forward surface guide 302 can be covered by the body cover 1515 up to the point where the chuck 90 is exposed at the distal engagement end 120 of the instrument 10 and can exit the body cover 1515 through openings 1520.These openings can include bushings seated around the perimeter of the opening 1520 that are sealed from the remainder of the instrument body.", "The one or more body covers 1515 can be removed independently of one or more of the guides.", "Alternatively, the one or more body covers 1515 can be integrated with one or more of the guides such that they can be removed along with the covers 1515 in order to access the interior of the instrument 10.Proximally, the body 20 can include a removable end piece 150 that can be removed to gain access to the proximal region of the body 20 in order to clean or remove the modular portions of the instrument 10 near the proximal end, such as the drive shaft 40 and the drive motor 30.The removable end piece 150 can be incorporated with a removable electronics package as will be discussed in more detail below.", "One or more of the body covers can be translucent or transparent such that the components inside are visible from the outside without removal of the covers.", "It should also be appreciated that the components can be disposable and need not be removed or cleaned.", "Electronics and Sensors An electronics package 236 can be positioned within the body 20 of the instrument 10 and can have a variety of configurations.", "In an embodiment, the electronics package 236 can be positioned within the body 20 as well as within the handle 25.In an embodiment, the electronics package 236 can be positioned within a space of the body 20, for example near or at the proximal end behind drive motor 30 (see for example, FIG.", "5 or 6).", "The electronics package 236 can include a display.", "The electronics package 236 and display can be removable along with one or more of the body covers.", "Information regarding the use of the instrument 10 can be relayed in real-time to the display such that the information is provided to a user instantaneously during use of the instrument 10, for example bore depth or other information as will be described in more detail below.", "The display can include an LED or other display using, for example, electrical filaments, plasma, gas or the like.", "The instrument 10 can also include a display that is not coupled or integrated within the instrument itself, for example, a heads-up display that communicates with the instrument 10 (i.e.", "either wired or wirelessly).", "The heads-up display can include a graphical user interface (GUI) that can display data and provide interactive functions such as a touch screen for input of data and information such as the drill bit size.", "The heads-up display can be mounted as is known in the art such as with a boom or other mechanism that provides user convenience.", "For example, the heads-up display can be mounted on a boom that can be easily positioned and moved around during a surgical procedure.", "The heads-up display can be autoclavable such that the display can be positioned within the surgical field where a user is using the instrument 10.Alternatively, the heads-up display can be inserted into a sterile cover such that the display can be positioned within the surgical field where a user is using the instrument 10.The electronics package 236 (see FIGS.", "5-6) can communicate with various sensors positioned within the instrument 10 that assess the status of the components of the instrument and communicate this information in real-time to the electronics package 236 and the user via a display.", "The instrument 10 can provide the user with alerts and information regarding the status of the instrument and instrument components during use such that manual and/or automatic adjustments can be made.", "The electronics package 236 can also include motor control electronics and software programs that can be programmed to automatically adjust the instrument 10 in real-time to maintain use of the instrument 10 within set thresholds.", "For example, the instrument can include software capable of being programmed to continuously measure and/or control a variety of functions including, but not limited to, bone depth, material strength, bone density, skive, drill bit development, speed of rotation, acceleration, deceleration, irrigation, voltage, torque, thrust, feed rate, current, voltage, axial movement, axial force and other functions of the instrument or a combination thereof.", "The instrument can include mechanical measurement systems, such as a mechanical torque measurement system as will be described in more detail below.", "As such, the instruments described herein can detect and control penetration of the working tool through various tissue layers.", "The instruments can control, for example, axial feed rate, motor RPM, and engagement of the work to allow a user to avoid certain unsafe instrument situations.", "For example, the instruments described herein can detect joint penetration in real-time allowing a user to avoid “pop through” or plunging situations, for example, in which the instrument suddenly penetrates the cortical bone and inadvertently damages soft tissue or joint structures.", "Joint penetration can occur perpendicularly as well as tangentially (also known as skiving).", "The instruments described herein can provide an overall system stability that allows for the accurate tracking and detection and control of instrument status during use.", "It should be appreciated that the control of the instruments described herein can also be adjusted manually by the user.", "For example, the user can change the thrust of the drive motor 30 by letting up or pressing down on the actuator 32.The user can also change the thrust of the instrument 10 by pushing down or letting up on the axial pressure being applied to the instrument 10.In an embodiment, tissue resistance as compared to axial pressure on the instrument 10 applied by the user can cause/allow the relative position of the handle of the instrument 10 to feel as if it were backing out of the work as the tool 110 is axially extended from the instrument 10.This can require the user to apply additional axial pressure to drive the tool 110 through the tissue.", "The torque as related to the rotating tool 110 can also change during use of the instrument 10.This change provides feedback to the user who in turn can make appropriate adjustments to the axial and rotational movements as needed.", "The instruments 10 described herein can instantaneously measure the axial motion and the depth the working tool 110 travels into the work by a transducer or encoder, such as an incremental rotary encoder, an absolute rotary encoder, mechanical, magnetic, electrical, or optical rotary encoder, or the like (see for example BEI Optical encoder; www.motion-control-info.com/encoder_design_guide.html).", "The depth the working tool 110 travels into the work can also be measured by a synchro, a resolver, a rotary variable differential transformer (RVDT) or a rotary potentiometer, or the like.", "As shown in FIG.", "14, the rotary encoder 39 can include a bearing housing assembly 201, a light source 202, a code disc 203, a mask 204, a photodetector assembly 205, an electronics board 206 that rotate around shaft 208.In an embodiment, the rotary encoder is an incremental rotary encoder with dual channels in quadrature with an additional data track to provide an internal position reference for setting a “zero point”.", "The rotary encoder can be an absolute rotary encoder.", "The encoder can measure rotation and convert that information into axial motion.", "The encoder can interface with the drive motor 30 and the drive shaft 40 and can provide instantaneous information on the position of the drive shaft 40 regarding the depth of axial movement of the working tool into a bore.", "This information can be fed to the electronics package 236 that can perform count multiplication to determine the tool position.", "For example, the rotation of the drive shaft 40 can be measure and a calculation performed to determine the distance traveled.", "This distance traveled can be compared to a set point or zero point such that the position of the working tool 110 from the distal end of the instrument can be calculated.", "This calculation relates to depth as determined by the position of the distal end of the instrument with respect to the target tissue (e.g.", "bone).", "In an embodiment, the instrument can include a meter that measures the rotational speed (see for example the speed device described in U.S. Pat.", "No.", "4,723,911), time, velocity, acceleration, deceleration or torque.", "The meter can provide the user information pertaining to the passage of the working tool 110 through different layers of tissue.", "For example, movement of the working tool 110 through cortical bone into medullary canal or cancellous bone, medullary canal or cancellous bone to cortical bone, or from cortical bone to soft tissue.", "In an embodiment, metrics can be obtained via an axial force sensor and/or a torque sensor to measure drive or motor torque directly.", "In an embodiment, the rotational drive motor 60, or a gearbox connected to the rotational motor 60, can be positioned such that it can press against a force sensor to provide direct measurements of torque that can be displayed to a user and provide information pertaining to the passage of the tool through varied layers of tissue.", "In another embodiment the rotational drive motor 60 can have a torque sensor (not shown).", "In an embodiment the rotation drive motor 60 can be a brushless DC (BLDC) electric motor having one or more Hall sensors.", "When the tool passes from cortical bone into medullary canal or cancellous bone or from cortical bone into soft tissue the measured torque can drop dramatically.", "The information can be relayed to the display 236 and integrated with the function of the motor drivers and their actuators.", "For example, in an embodiment, when the tool 110 is moving axially in a forward direction and passes from cortical bone to medullary canal or cancellous bone or from cortical bone to soft tissue the reduced torque will interrupt the axial motion.", "The axial drive can then be reengaged by releasing pressure on the forward two-stage trigger and reapplying pressure.", "The instruments 10 described herein can also control the depth of penetration of the working tool 110.In an embodiment, the maximum depth of the bore that is to be created by the instrument 10 can be programmed with electronics in advance of drilling.", "The measurement can be zeroed by the user prior to use, for example, by depressing an axial measurement selector/reset button.", "This allows the user to zero the measurement according to the length of the selected tool 110.In one embodiment, the distal end of the working tool 110 can be aligned with the distal end of the body 20 and the instrument zeroed.", "This can be performed manually by the user or electronically with set points and a feedback system (i.e.", "interface with the coupler).", "The alignment of the distal end of the tool 110 and the distal end of the body 20 can be such that the two are flush with one another or the distal end of the tool 110 can be some distance beyond the distal end of the body 20, for example between about 3 mm and 7 mm.", "The tool 110 can be positioned flush against the bone prior to drilling.", "As the tool 110 advances into the bone, the instrument 10 can be held flush against the bone.", "The instrument 10 can also include a distal guide 170 and be zeroed once the tool 110 aligns with the distal end of the guide 170 (and a fixation plate attached to the guide 170, if present).", "Once the cut is started and the tool 110 can be flush with the bone, the user can use the axial drive to further advance the tool 110 through the bone.", "The electronics package 236 can be zeroed as described above to include the additional axial length of the guide 170.In another embodiment, the user can feed in a distal direction a portion of the working tool 110, for example 30 mm if working on a tibia or femur or 12 mm if working on a radius.", "The user can then manually drill through the bone as with an axially static drill.", "Upon reaching that pre-programmed depth, if the distal cortex had not yet been breached, the axial drive can be used to penetrate the bone further.", "In another embodiment, the electronics can contain a preset maximum distance that can limit the distal travel of the tool 110.For example, a stop and go signal (i.e.", "single click of the trigger) or a double stop and go (i.e.", "double click of the trigger) can release the depth stop and allow further travel.", "Any of a variety of schedules can be programmed into the electronics to control distal advancement of the tool.", "For example, each time the tool 110 is advanced beyond the initial stop, the electronics can be programmed to allow only a further distal travel of for example 3 mm or 6 mm or other incremental distance before stopping again and alerting the user similar to a snooze alarm system of a clock radio.", "Identifying the desired depth of penetration for pre-programmed embodiments can be determined, for example, by knowing the typical size of the target tissue based upon the age and size of a patient or the actual size of the target tissue from pre-op radiographs, CT scans or MRI scans.", "A user can also manually estimate to approximately 70-80% depth travel through the proximal cortex, the medullar bone and close to or into the distal cortex prior to the automatic pre-programmed settings taking effect.", "For example, the user can manually estimate until a region of the bone is entered where a greater amount of control is desirable such as the distal cortex.", "At that stage, the axial drive of the instrument can be used to slowly proceed through that portion of the bone to the target location.", "A user can also proceed until a pop is felt or a change in speed can be heard in the drill.", "This can be augmented by acceleration or torque measurements provided to the user.", "For example, as the drill bit penetrates to the very last layers of the distal cortex it can begin to accelerate with a burst of acceleration as it breeches the distal cortex completely, this can also be sensed as a change in torque.", "In another embodiment, the RPM of the rotational drill motor is kept constant, preventing tool acceleration or deceleration.", "This allows the torque to be correlated to material strength.", "The instrument can provide its own auditory output to accentuate the sometimes subtle auditory changes caused by the drill bit.", "Upon reaching the predetermined target depth, axial movement of the device can automatically slow or stop while rotational movement can continue.", "It should be appreciated, however, that the user can manually override any pre-programmed limitations or automated controls by actuation/triggers on the device without changing hand positions to continue.", "As described above, the instruments described herein can include one or more sensors that communicate information to the user using a variety of alert mechanisms and/or graphical displays.", "In an embodiment, the instrument includes an axial force sensor and an axial force alert.", "As described herein, the axial force sensor can be used to sense the axial force applied at the distal end of the drill guide and/or applied by the working tool.", "The axial force sensor can communicate with the axial force alert and provide information to the user to ensure that the distal end of the drill guide and/or tool stay engaged with the work and maintains an appropriate level of pressure.", "Applying too much pressure or force on the work can increase the risk for damage to the work or surrounding tissues.", "Applying too little pressure or force can cause the tool to back off the work and prevent tool advancement at the desired rate.", "The axial force sensor can communicate with the axial force alert in real-time to provide the user with information regarding the status of the drill guide and whether the applied axial force is at the desirable pressure for an optimum result.", "The axial force alert can include an alarm or other auditory signal, a light or other visual signal, a vibration or other tactile signal, or a combination thereof.", "In an embodiment, the visual output can be an LED light or graphical interface positioned in the line of sight with the work, for example near or at the proximal end or back of the device.", "The output of the axial force alert can be proportional to the axial force being applied.", "For example, the axial force alert can include a light that can change color or a plurality of lights that sequentially illuminate depending on the axial force applied.", "Alternatively, the axial force alert can include an auditory alert that changes pitch or frequency depending on the axial force applied.", "In use, the user can inadvertently lighten manually applied forward (or axial) pressure on the instrument 10 that can result in a slowing of progress into the work and consequently the drill guide from backing away from the work.", "A user can maintain forward pressure on the instrument 10 such that the working tool 110 drives into the bone distally as the guides retract in a proximal direction.", "If a user does not maintain forward pressure the instrument 10 can be pushed in a proximal direction resulting in the working tool 110 not moving into the work.", "It can be desirable, however, to use as little forward pressure on the instrument as necessary to avoid injury to the bone.", "In some embodiments, the instrument 10 can include an axial force sensor that can measure the axial force a user applies to the work.", "The axial force sensor can interact with the electronics and provide an output to the user (e.g.", "visual or auditory or other output) to indicate when an amount of pressure is being applied by the user.", "The instrument can be programmed to provide the output to the user when an appropriate amount of pressure is being applied or when the pressure being applied falls outside a programmed range.", "In one example, LED lights can be positioned near a proximal end of the instrument within a user's line-of-sight such that the axial force applied can be visualized.", "For example, a flashing white LED can mean too little axial pressure is being applied, a green LED can mean the axial pressure is in a desired range and a flashing red LED can mean the axial pressure is too high.", "The instruments described herein can also include a torque sensor that detects the torque applied by the rotational motor and a torque alert.", "As described previously in reference to the axial force alert, the torque alert can also include an alarm or other auditory signal, a light or other visual signal, a vibration or other tactile signal, or a combination thereof.", "For example, the sensed torque similar to the sensed axial force can be displayed visually such as on a graphical interface in the line of sight with the work.", "The torque alert can also be proportional relative to the torque being applied.", "Further, the output for the axial force alert can be distinguishable from the output for the torque alert.", "For example, a first auditory signal can be provided by the axial force alert proportional to the axial force and a second auditory signal can be provided by the torque alert proportional to the torque applied.", "The auditory signals from the two alerts can be distinguishable by the user as being separate.", "For example, the axial force alert can be a different pitched auditory signal compared to the torque alert.", "In another embodiment, the axial force alert can signal the user only when conditions at the work change, whereas the torque alert can be a continuous signal, such as a sound with a variable pitch that is proportional to the torque or energy being sensed.", "It should be appreciated that any number of sensors and a variety of alerts or graphical information can be used singly or in combination as is known in the art.", "The systems described herein can also provide information to the user regarding optimal screw placement even in the case of a shared or convergent drill hole for the placement of interference screws, such as screws that are purposefully touching.", "Clinically, a user can feel when an interference screw is contacted by a drilling or driving device.", "However, once the interference screw is engaged the distal cortex can no longer be clinically felt by the user and a myriad of potential problems exist with regard to injury of distal structures.", "Both the interference screw and the distal cortex can be detected by tracking changes in the metrics, for example current or measured torque.", "The data can be used to inform the user in real-time when the instrument is in contact with one or more of the bone cortices or the screw.", "Similarly, the instruments described herein can provide instant, intra-operative feedback on drill bit performance such as drill flute clogging and the assessment of drill bit sharpness using a calibration block.", "Material strength and bone density can be determined by comparing intraoperative metrics such as current, measured torque or axial force with existing empirical data obtained while drilling with known drill bit sizes, drill bit types, axial feed rates and motor RPMs.", "The instruments described herein therefore can be useful in diagnosing bone pathologies such as osteoporosis and the detection of holes or fractures in the bone being drilled.", "Further, material strength and bone density data can assist a user in choosing an appropriate fixation technique, e.g.", "non-locking (cortical or cancellous) versus locking (unicortical or bicortical).", "Conventionally, to select the appropriate fixation technique a user must make an educated guess or using bone density data obtained prior to the fracture to estimate local material strength at the fracture fixation site.", "For example, dual energy X-ray absorptiometry (DEXA) scans are commonly used to measure bone density and monitor osteopenia or osteoporosis treatments.", "But a DEXA scan cannot be performed acutely for a fracture patient and the standardized regional measurements may not be relevant at the fracture site.", "The instruments described herein provide an advantage in that determination of bone strength and bone density can be performed in acute situations and in real-time at the fracture site.", "Drilling torque (or energy) of the working tool is related to the properties of the bone, such as its material strength and its bone density.", "One or more of the sensors described herein can be used to estimate the material strength and bone density such that the instrument can detect transitions between different types of bone, as well as entry and exit from bone in real-time.", "As shown in FIG.", "15, a motor 60 can rotate and produce a motor torque Tm that is in the direction of rotation of a working tool 110 coupled to the motor 60.Drilling torque Td is opposite the direction of rotation of the working tool 110.A gearbox 75 can be incorporated in the instrument to convert the high-speed, low-torque operation of the motor 60 to a higher torque working tool 110 speed.", "The gearbox 75 can exhibit an additional torque component Tg due to internal energy losses, such as mechanical losses in the form of drag that counteracts torque and can result in a loss of energy between the motor 60 and the working tool 110.Gearbox torque Tg is also opposite the direction of rotation of the working tool 110.The motor 60 can be held as the reference point and the motor torque Tm measured electronically.", "In this embodiment, the instrument measures the current required to operate the motor 60, for example a brushless DC motor with a Hall Sensor that operates a drive train, and the motor 60 acts as both the actuator and the sensor.", "Motor torque measurements in this embodiment include both drilling torque Td and gearbox Tg losses.", "The gearbox inefficiencies can affect the accuracy of the torque measurements.", "The error in estimating the drilling torque component can be more pronounced for larger gear ratios in that more gears have more surface contact and thus, more drag.", "In another embodiment, the instrument can directly measure torque (see FIG.", "16).", "The gearbox 75 is held as a reference point for the torque measurement and only the drilling torque Td is measured.", "Measurements of the drilling torque Td can be taken at the output of the gearbox 75 such that internal gearbox losses are not included in the torque measurement although the motor 60 may still drive against the internal drag.", "A discrete sensor can be incorporated in the instrument to convert the drilling torque Td into a measurement signal.", "A mechanical beam or level can be incorporated to support the gearbox 75 and convert the torque Td into a linear force.", "The linear force can be converted into an electrical signal using a strain gauge load cell or scale or other torque sensor 77 to measure the resulting linear force.", "The direct torque measurement does not measure the energy lost internally to the gearbox 75 or the other motor components.", "The motor 60 can exert torque between its shaft and housing, which can be rigid mounted to the gearbox 75.In this embodiment, the torque required to overcome the internal losses of the gearbox 75 can be transferred through the housing of the motor 60 and gearbox 75 and the mechanical path does not include a torque sensor.", "The torque sensor 77 can, instead be positioned between the gearbox housing 75 and the working tool 110 by attaching the torque sensor 77 to the drill housing.", "The user can hold the body 20 of the instrument 10, which is rigidly attached to the gearbox housing 75.Although motor self-torque measurement can be more convenient since no additional sensor is needed, the accuracy can be lower than for a direct torque measurement in which a torque sensor is used.", "Direct torque measurements from a manufacturing standpoint can also allow one to design the gearbox independently from the torque measurement sensitivity.", "The instrument 10 can be a corded or cordless powered instrument.", "In an embodiment, the instrument 10 includes and is powered by a removable battery 360 (see FIG.", "5).", "The battery 360 can be enclosed within a battery cover 362 capped on the bottom by a battery case cover 364.The body 20 can accept battery release buttons 366.The battery 360 can have different chemical compositions or characteristics.", "For instance, batteries can include lead-acid, nickel cadmium, nickel metal hydride, silver-oxide, mercury oxide, lithium ion, lithium ion polymer, or other lithium chemistries.", "The instruments can also include rechargeable batteries using either a DC power-port, induction, solar cells or the like for recharging.", "Power systems known in the art for powering medical devices for use in the operating room are to be considered herein.", "Methods of Use Below is an example of a method of using an instrument described herein.", "It should be appreciated that a variety of driving devices or working tools can be coupled to the instruments described herein.", "Description related to guides on a drilling device having a drill bit coupled thereto is not intended to be limited to only drills and drilling bores.", "Rather, the instruments and guides can be used to saw or drive into tissues as described herein.", "It should be appreciated that any of the instruments described herein can be coupled to robotic arms or robotic systems or other computer-assisted surgical systems in which the user uses a computer console to manipulate the controls of the instrument.", "The computer can translate the user's movements and actuation of the controls to be then carried out on the patient by the robotic arm.", "Robotics can provide real-time pre- and inter-operative tactile and/or auditory feedback along with visualization, such as three-dimensional modeling.", "The robotic system can have an articulated endowrist at the end of two or more “working” arms configured to be inserted through a small portal.", "A stable, camera arm with two lenses (allowing stereoscopic images) can be also inserted through another small portal.", "The end-effectors can manipulate instruments and can have various degrees of freedom.", "The user can control the robot through a console placed in the operating room, allowing control of both the external and internal surgical environments.", "The user's interface can have instrument controllers that can filter tremor and decrease the scale of motion.", "Foot pedals can expand the user's repertoire, allowing tissue coagulation and irrigation.", "Visual feedback can be through a stereoscopic display.", "Robotic systems to which the devices disclosed herein can be coupled include the Haptic Guidance System or RIO® Systems (MAKO Surgical Corp, Ft. Lauderdale, Fla.) and the da Vinci® Surgical Systems (Intuitive Surgical, Sunnyvale, Calif.).", "Other surgical robots can be considered as well including the Robot-Assisted Micro-Surgery (RAMS) system (MicroDexterity Systems, Inc.), NeuroArm® (University of Calgary), Zeus® Surgical robots, SpineAssist (Mazor Surgical Technologies, Israel), ROBODOC and ORTHODOC (Curexo Technology Corp., Fremont, Calif.), ACROBOT (Acrobot, Elstree, UK), PathFinder (Prosurgics Ltd., Loudwater, High Wycombe, UK), and Laprotek system (Hansen Medical, Inc.).", "Other robotic arms can be used with the instruments described herein such that the instrument can be independently controlled by the robot as opposed to direct manipulation by the user.", "In one embodiment of the method, the user can dissect tissue down to the bone and create a field large enough to put against the bone the working tool 110 or distal guide 170 or an implant attached to the distal guide 170.Screws can be placed across fractures without any other implants or a plate can be fixed across the fracture by bone screws.", "The screws can lock into the plate and bone.", "When a plate is to be used, the user can create a field large enough to place the plate.", "Alternatively, the plate can be inserted through a small incision such that the user can slide it along the surface of the bone in combination of blunt dissection of the tissue along the way (i.e.", "subcutaneous plate).", "The screws can be placed, for example using a radiograph to find the holes in the plate, through small incisions through the skin with dissection down to the bone.", "The surrounding tissue can be protected using retractors, a guide through which the working tool is inserted, attachable guides placed on the instrument and the like.", "If a distal guide 170 is used, the length of the guide 170 can be accounted for in the depth measurement.", "If a guide 170 attached to an implant is used, the depth can be automatically or manually zeroed.", "For example, if a plate is used the thickness of the plate can be automatically or manually accounted for in the zeroing.", "The working end of the instrument 10, with or without a distal guide 170, can be placed next to the exposed and dissected bone and the instrument zeroed.", "Alternatively, the user can extend a few millimeters of the working tool 110 to engage the bone and drill a counter-sink or pilot hole prior to zeroing the instrument 10.Where a fixation plate is used, the plate can be placed next to the bone and the drill end placed snug to the plate.", "Alternatively, some plates have guides that interface such that the instrument is directed at a selected angle.", "The instruments disclosed herein can be made such that they attach to or freely engage these types of distal guides 170.The user can apply pressure axially and engage first the rotational drive motor 60 to the desired speed.", "The user can proceed to engage the axial drive motor 30 either continuously or incrementally, depending upon the material strength and bone density and preference of the user.", "The drilling can continue through the cortical bone, through the medullary canal or cancellous bone, into and through the distal cortical bone.", "Once through the distal cortical bone as determined by pre-set depth control mechanism, axial resistance, auditory feedback from the rotational speed of the drill bit and/or auditory feedback from acceleration or torque sensors, the axial movement can be stopped.", "The user can remove the working tool 110 by reversing the axial drive motor 30 or by pulling back on the instrument 10.The rotational drive motor 60 can be left engaged and in the forward direction to facilitate clearing the hole created.", "The user can read the depth on the display 236 and select the proper screw for implantation.", "The screw can be implanted using a screw driver or the like.", "In another method, the user can perform a unicortical procedure wherein the working tool is stopped prior to some other endpoint such as before or after a growth plate or before or after the distal cortex.", "In use, an instrument 10, such as the instrument shown in FIG.", "4, can be set against exposed bone or, if used, the fracture fixation plate or other type of implant such as a joint prosthetic.", "The appropriate zero-depth position can be determined automatically.", "Once the user activates the trigger 232, the guide 170 as well as the guides 300, 302 retracts in the proximal direction (arrow P) and the working tool 110 can extend through the guide 170.The working tool 110 can engage the work and bore into the work as the user applies pressure to the instrument 10 and keeps it engaged with the work.", "The working tool 110 can drill into the bone by the amount the guide 170 retracts.", "The guide 170 retraction can be measured instantaneously and shown on a display, for example a display positioned at the back of the instrument 10.The automatic determination of the zero-position whether set against bone or against a fracture fixation plate can depend upon algorithms related to the way the guide 170 sets against the bone or the plate and the thickness of the plate.", "These variables can be unique to each plating system and set of guides.", "The depth of the travel of working tool 110 into the work, and/or the instantaneous torque or torque curve, can be measured and shown on the display 236 simultaneously and instantaneously as the working tool 110 moves axially in a distal direction and penetrates the work.", "Once the desired depth of penetration is reached, the reverse trigger 234 can be actuated to cause both of the drive motors 30, 60 to reverse their direction.", "The action of the axial drive motor 30 can cause the drive lug 240, the rear surface guide 300, the forward surface guide 302 and the guide 170 to move in an axial direction away from the body 20 of the instrument 10 in a distal direction such that the axial movement pushes the instrument body 20 away from the work and draws the tool 110 out of the work.", "Alternatively, the operator can pull the tool 110 from the work with the instrument either on (in any direction) or off.", "Aspects of the subject matter described herein may be realized in digital electronic circuitry, integrated circuitry, specially designed ASICs (application specific integrated circuits), computer hardware, firmware, software, and/or combinations thereof.", "These various implementations may include implementation in one or more computer programs that are executable and/or interpretable on a programmable system including at least one programmable processor, which may be special or general purpose, coupled to receive data and instructions from, and to transmit data and instructions to, a storage system, at least one input device, and at least one output device.", "For example, a software program can be incorporated into the device that takes advantage of the reproducible relationship between current, torque, material strength and density in a system where the RPM of the rotational motor is held constant.", "Current is proportional to torque and torque is proportional to bone strength and density.", "As such the software can correlate the current the motor uses during drilling or sawing to the material strength and bone density.", "Such a software program can be used to measure material strength and bone density in real-time by reading the current being used by the motor.", "The software program can also be used to control RPM, feed rate, current and/or voltage.", "These computer programs (also known as programs, software, software applications or code) include machine instructions for a programmable processor, and may be implemented in a high-level procedural and/or object-oriented programming language, and/or in assembly/machine language.", "As used herein, the term “machine-readable medium” refers to any computer program product, apparatus and/or device (e.g., magnetic discs, optical disks, memory, Programmable Logic Devices (PLDs)) used to provide machine instructions and/or data to a programmable processor, including a machine-readable medium that receives machine instructions as a machine-readable signal.", "The term “machine-readable signal” refers to any signal used to provide machine instructions and/or data to a programmable processor.", "While this specification contains many specifics, these should not be construed as limitations on the scope of the claims or of what can be claimed, but rather as descriptions of features specific to particular embodiments.", "Certain features that are described in this specification in the context of separate embodiments can also be implemented in combination in a single embodiment.", "Conversely, various features that are described in the context of a single embodiment can also be implemented in multiple embodiments separately or in any suitable sub-combination.", "For example, a current sensing mechanism can be incorporated into a drill or saw device and used independently of a depth-control mechanism.", "Similarly, a depth-control mechanism can be incorporated into a device that does not include other sensing mechanisms.", "Moreover, although features can be described above as acting in certain combinations and even initially claimed as such, one or more features from a claimed combination can in some cases be excised from the combination, and the claimed combination can be directed to a sub-combination or a variation of a sub-combination.", "Similarly, while operations are depicted in the drawings in a particular order, this should not be understood as requiring that such operations be performed in the particular order shown or in sequential order, or that all illustrated operations be performed, to achieve desirable results.", "Although embodiments of various methods and devices are described herein in detail with reference to certain versions, it should be appreciated that other versions, embodiments, methods of use, and combinations thereof are also possible.", "Therefore the spirit and scope of the appended claims should not be limited to the description of the embodiments contained herein." ] ]
Patent_15876078
[ [ "MULTI-CHIP PACKAGE AND METHOD OF PROVIDING DIE-TO-DIE INTERCONNECTS IN SAME", "A multi-chip package includes a substrate (110) having a first side (111), an opposing second side (112), and a third side (213) that extends from the first side to the second side, a first die (120) attached to the first side of the substrate and a second die (130) attached to the first side of the substrate, and a bridge (140) adjacent to the third side of the substrate and attached to the first die and to the second die.", "No portion of the substrate is underneath the bridge.", "The bridge creates a connection between the first die and the second die.", "Alternatively, the bridge may be disposed in a cavity (615, 915) in the substrate or between the substrate and a die layer (750).", "The bridge may constitute an active die and may be attached to the substrate using wirebonds (241, 841, 1141, 1541)." ], [ "1.A multi-chip package comprising: a substrate having a first side, an opposing second side, and a third side that extends from the first side to the second side, the third side constituting a portion of an outside perimeter of the substrate; a first die attached to the first side of the substrate and a second die attached to the first side of the substrate; and a bridge adjacent to the third side of the substrate and attached to the first die and to the second die, wherein no portion of the substrate is underneath the bridge and wherein the bridge creates a connection between the first die and the second die.", "2.A method of providing die-to-die interconnects in a multi-chip package, the method comprising: providing a substrate having a first side, an opposing second side, and a third side that extends from the first side to the second side; attaching a first die to the first side of the substrate such that a portion of the first die extends beyond an edge of the first side of the substrate; attaching a second die to the first side of the substrate such that a portion of the second die extends beyond the edge of the first side of the substrate; providing a bridge containing a plurality of electrically or optically conductive features; positioning the bridge adjacent to the third side of the substrate such that no portion of the substrate is underneath the bridge; and attaching the bridge to the first die and to the second die, thereby creating a connection between the first die and the second die.", "3.The method of claim 2 wherein: the bridge comprises silicon.", "4.The method of claim 3 wherein: the bridge comprises an active die that constitutes a third die of the multi-chip package; and the bridge is attached to the first die and to the second die using flip-chip connections.", "5.The method of claim 4 further comprising: attaching the bridge to the substrate using a wirebond.", "6.The method of claim 3 wherein: attaching the bridge comprises using a thermocompression bonding process.", "7.The method of claim 3 wherein: attaching the bridge comprises using a solder reflow process.", "8.The method of claim 3 wherein: providing the substrate comprises forming an aperture through the substrate such that the third side constitutes a portion of an inside perimeter of the substrate.", "9.The method of claim 3 wherein: providing the substrate comprises forming a slot in the substrate such that the third side constitutes a portion of an outside perimeter of the substrate.", "10.A method of providing die-to-die interconnects in a multi-chip package, the method comprising: attaching a first die and a second die to a carrier; attaching a bridge to the first die and to the second die; providing a substrate; and attaching the first die and the second die to the substrate.", "11.The method of claim 10 wherein: the substrate has a cavity therein; and attaching the first die and the second die to the substrate comprises locating the bridge within the cavity.", "12.The method of claim 10 further comprising: removing the carrier.", "13.The method of claim 10 wherein: the carrier comprises a heat spreader.", "14.The method of claim 10 wherein: attaching the bridge comprises using a thermocompression bonding process.", "15.The method of claim 10 wherein: the bridge comprises silicon.", "16.The method of claim 15 wherein: the bridge comprises an active die that constitutes a third die of the multi-chip package; the bridge is attached to the first die and to the second die using flip-chip connections; and the method further comprises attaching the bridge to the substrate using a wirebond.", "17.A multi-chip package comprising: a substrate containing a cavity having a plurality of pads therein; a first die attached to the substrate and a second die attached to the substrate; a bridge having a first side and an opposing second side; and a plurality of joints at the second side of the bridge, wherein: the first die and the second die are attached to the first side of the bridge; at least a portion of the bridge is located within the cavity such that the plurality of joints are aligned with the plurality of pads; and the bridge creates a connection between the first die and the second die.", "18.The multi-chip package of claim 17 wherein: the bridge comprises silicon.", "19.The multi-chip package of claim 18 wherein: the bridge is attached to the first die and to the second die using flip-chip connections; the bridge comprises an active die that constitutes a third die of the multi-chip package; and the bridge is attached to the substrate using a wirebond.", "20.The multi-chip package of claim 18 wherein: the first die has a first portion containing a first plurality of interconnect structures and a second portion containing a second plurality of interconnect structures; the second die has a third portion containing a third plurality of interconnect structures and a fourth portion containing a fourth plurality of interconnect structures; the first plurality of interconnect structures and the third plurality of interconnect structures have a first pitch; the second plurality of interconnect structures and the fourth plurality of interconnect structures have a second pitch that is different from the first pitch; and the first portion and the third portion are attached to the bridge.", "21.A method of providing die-to-die interconnects in a multi-chip package, the method comprising: providing a substrate having a plurality of embedded pads; forming a cavity in the substrate such that the pads are exposed at a floor of the cavity; providing a bridge having bumps thereon corresponding to the pads; placing the bridge in the cavity and aligning the bumps and the pads to each other; providing a first die and a second die; and attaching the first die and the second die to the bridge and the substrate.", "22.The method of claim 21 wherein: the bridge comprises silicon.", "23.The method of claim 22 wherein: the bridge comprises an active die that constitutes a third die of the multi-chip package; the bridge is attached to the first die and to the second die using flip-chip connections; and the method further comprises attaching the bridge to the substrate using a wirebond.", "24.The method of claim 22 wherein: forming the cavity comprises using one of a laser milling and a plasma etching process.", "25.A multi-chip package comprising: a substrate; a first active die attached to the substrate using a first flip-chip connection; and a second active die, wherein the second active die is attached to the first active die using a second flip-chip connection and wherein the second active die is also attached to the substrate using a wirebond, wherein: the second active die has a first region and a second region; the first region is an overlap region located between the substrate and a portion of the first active die; and the second flip-chip connection is located in the first region of the second active die and the wirebond is attached to the second active die in the second region.", "26.The multi-chip package of claim 25 wherein: the first region of the second active die has a first section and a second section; and the first section contains a first plurality of flip-chip connections having a first density and the second section contains a second plurality of flip-chip connections having a second density less than the first density.", "27.The multi-chip package of claim 26 wherein: the first region further comprises a third section that contains a third plurality of flip-chip connections having a third density less than the first density; and the first section is located between the second section and the third section.", "28.The multi-chip package of claim 25 wherein: the substrate contains a cavity; and the second active die is at least partially located in the cavity.", "29.A method of providing die-to-die interconnects in a multi-chip package, the method comprising: providing a substrate; attaching a first active die to the substrate using a first flip-chip connection; attaching a second active die to the first active die using a second flip-chip connection; and attaching the second active die to the substrate.", "30.The method of claim 29 wherein: the second active die is attached to the substrate using a wirebond.", "31.A multi-chip package comprising: a substrate; a first active die attached to the substrate using a first flip-chip connection; a second active die, wherein the second active die is attached to the first active die using a second flip-chip connection and wherein the second active die is also attached to the substrate using a wirebond; and a third active die attached to the substrate using a third flip-chip connection and attached to the second active die using a fourth flip-chip connection, wherein: the second active die connects the first active die to the third active die; the second active die has a first region, a second region, and a third region; the first region is a first overlap region located between the substrate and a portion of the first active die; the third region is a second overlap region located between the substrate and a portion of the third active die; the second flip-chip connection is located in the first region of the second active die and the wirebond is attached to the second active die in the second region; and the fourth flip-chip connection is located in the third region of the second active die.", "32.The multi-chip package of claim 31 wherein: the first region of the second die has a first section and a second section; the third region of the second die has a third section and a fourth section; the first section contains a first plurality of flip-chip connections having a first density and the second section contains a second plurality of flip-chip connections having a second density less than the first density; and the third section contains a third plurality of flip-chip connections having a third density and the fourth section contains a fourth plurality of flip-chip connections having a fourth density less than the third density.", "33.The multi-chip package of claim 32 wherein: the second active die comprises electrically or optically conductive traces extending between the first section and the third section; and the electrically or optically conductive traces connect the first active die to the third active die.", "34.The multi-chip package of claim 31 wherein: the substrate contains a cavity; and the second active die is at least partially located in the cavity.", "35.A method of providing die-to-die interconnects in a multi-chip package, the method comprising: providing a substrate; attaching a first active die to the substrate using a first flip-chip connection; attaching a second active die to the substrate using a second flip-chip connection; attaching a third active die to the first active die using a third flip-chip connection; attaching the third active die to the second active die using a fourth flip-chip connection; and attaching the third active die to the substrate.", "36.The method of claim 35 wherein: the third active die is attached to the substrate using a wirebond." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>A continuing focus of the microelectronics industry is the enablement of computer chips (also referred to as dies) having greater density, higher performance, and lower cost.", "As part of this effort, microelectronic packages containing multiple dies have been developed.", "Such multi-chip packages (MCPs) offer the potential for increased architectural flexibility at reduced cost but to do so must provide appropriate die-to-die interconnect densities in a way that is cost-effective.", "The interconnect density is an important consideration because an insufficient number of die connections would limit the bandwidth capability for the affected die interface, and thus logic-logic and/or logic-memory communications would suffer." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>The disclosed embodiments will be better understood from a reading of the following detailed description, taken in conjunction with the accompanying figures in the drawings in which: FIGS.", "1A, 1B, and 1C are plan views of a multi-chip package according to various embodiments of the invention; FIG.", "2 is a cross-sectional view of the multi-chip package of FIG.", "1C according to an embodiment of the invention; FIGS.", "3 and 4 are flowcharts illustrating methods of providing die-to-die interconnects in a multi-chip package according to embodiments of the invention; FIGS.", "5-8 are cross-sectional views of multi-chip packages at various particular points in their manufacturing processes according to embodiments of the invention; FIG.", "9 is a cross-sectional view of a multi-chip package according to another embodiment of the invention; FIG.", "10 is a flowchart illustrating a method of providing die-to-die interconnects in a multi-chip package according to another embodiment of the invention; FIG.", "11A is a plan view and FIGS.", "11B and 11C are cross-sectional views of a multi-chip package according to other embodiments of the invention; FIG.", "12 is a plan view of one of the active dies in the multi-chip package of FIGS.", "11A-11C according to an embodiment of the invention; FIG.", "13 is a plan view of an active die according to an embodiment of the invention; FIG.", "14 is a flowchart illustrating a method of providing die-to-die interconnects in a multi-chip package according to another embodiment of the invention; FIG.", "15 is a plan view of a multi-chip package according to another embodiment of the invention; FIG.", "16 illustrates some examples of multi-chip package geometries according to various embodiments of the invention; and FIG.", "17 is a flowchart illustrating a method of providing die-to-die interconnects in a multi-chip package according to another embodiment of the invention.", "detailed-description description=\"Detailed Description\" end=\"lead\"?", "For simplicity and clarity of illustration, the drawing figures illustrate the general manner of construction, and descriptions and details of well-known features and techniques may be omitted to avoid unnecessarily obscuring the discussion of the described embodiments of the invention.", "Additionally, elements in the drawing figures are not necessarily drawn to scale.", "For example, the dimensions of some of the elements in the figures may be exaggerated relative to other elements to help improve understanding of embodiments of the present invention.", "The same reference numerals in different figures denote the same elements, while similar reference numerals may, but do not necessarily, denote similar elements.", "The terms “first,” “second,” “third,” “fourth,” and the like in the description and in the claims, if any, are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order.", "It is to be understood that the terms so used are interchangeable under appropriate circumstances such that the embodiments of the invention described herein are, for example, capable of operation in sequences other than those illustrated or otherwise described herein.", "Similarly, if a method is described herein as comprising a series of steps, the order of such steps as presented herein is not necessarily the only order in which such steps may be performed, and certain of the stated steps may possibly be omitted and/or certain other steps not described herein may possibly be added to the method.", "Furthermore, the terms “comprise,” “include,” “have,” and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements is not necessarily limited to those elements, but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.", "The terms “left,” “right,” “front,” “back,” “top,” “bottom,” “over,” “under,” and the like in the description and in the claims, if any, are used for descriptive purposes and not necessarily for describing permanent relative positions.", "It is to be understood that the terms so used are interchangeable under appropriate circumstances such that the embodiments of the invention described herein are, for example, capable of operation in other orientations than those illustrated or otherwise described herein.", "The term “coupled,” as used herein, is defined as directly or indirectly connected in an electrical or non-electrical manner.", "Objects described herein as being “adjacent to” each other may be in physical contact with each other, in close proximity to each other, or in the same general region or area as each other, as appropriate for the context in which the phrase is used.", "Occurrences of the phrase “in one embodiment” herein do not necessarily all refer to the same embodiment." ], [ "CLAIM OF PRIORITY This application is a divisional of U.S. patent application Ser.", "No.", "13/531,827 filed Jun.", "25, 2012, which is a divisional of U.S. patent application Ser.", "No.", "12/459,007, now U.S. Pat.", "No.", "8,227,904, which was filed on Jun.", "24, 2009.FIELD OF THE INVENTION The disclosed embodiments of the invention relate generally to multi-chip packages, and relate more particularly to interconnect structures in such packages.", "BACKGROUND OF THE INVENTION A continuing focus of the microelectronics industry is the enablement of computer chips (also referred to as dies) having greater density, higher performance, and lower cost.", "As part of this effort, microelectronic packages containing multiple dies have been developed.", "Such multi-chip packages (MCPs) offer the potential for increased architectural flexibility at reduced cost but to do so must provide appropriate die-to-die interconnect densities in a way that is cost-effective.", "The interconnect density is an important consideration because an insufficient number of die connections would limit the bandwidth capability for the affected die interface, and thus logic-logic and/or logic-memory communications would suffer.", "BRIEF DESCRIPTION OF THE DRAWINGS The disclosed embodiments will be better understood from a reading of the following detailed description, taken in conjunction with the accompanying figures in the drawings in which: FIGS.", "1A, 1B, and 1C are plan views of a multi-chip package according to various embodiments of the invention; FIG.", "2 is a cross-sectional view of the multi-chip package of FIG.", "1C according to an embodiment of the invention; FIGS.", "3 and 4 are flowcharts illustrating methods of providing die-to-die interconnects in a multi-chip package according to embodiments of the invention; FIGS.", "5-8 are cross-sectional views of multi-chip packages at various particular points in their manufacturing processes according to embodiments of the invention; FIG.", "9 is a cross-sectional view of a multi-chip package according to another embodiment of the invention; FIG.", "10 is a flowchart illustrating a method of providing die-to-die interconnects in a multi-chip package according to another embodiment of the invention; FIG.", "11A is a plan view and FIGS.", "11B and 11C are cross-sectional views of a multi-chip package according to other embodiments of the invention; FIG.", "12 is a plan view of one of the active dies in the multi-chip package of FIGS.", "11A-11C according to an embodiment of the invention; FIG.", "13 is a plan view of an active die according to an embodiment of the invention; FIG.", "14 is a flowchart illustrating a method of providing die-to-die interconnects in a multi-chip package according to another embodiment of the invention; FIG.", "15 is a plan view of a multi-chip package according to another embodiment of the invention; FIG.", "16 illustrates some examples of multi-chip package geometries according to various embodiments of the invention; and FIG.", "17 is a flowchart illustrating a method of providing die-to-die interconnects in a multi-chip package according to another embodiment of the invention.", "For simplicity and clarity of illustration, the drawing figures illustrate the general manner of construction, and descriptions and details of well-known features and techniques may be omitted to avoid unnecessarily obscuring the discussion of the described embodiments of the invention.", "Additionally, elements in the drawing figures are not necessarily drawn to scale.", "For example, the dimensions of some of the elements in the figures may be exaggerated relative to other elements to help improve understanding of embodiments of the present invention.", "The same reference numerals in different figures denote the same elements, while similar reference numerals may, but do not necessarily, denote similar elements.", "The terms “first,” “second,” “third,” “fourth,” and the like in the description and in the claims, if any, are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order.", "It is to be understood that the terms so used are interchangeable under appropriate circumstances such that the embodiments of the invention described herein are, for example, capable of operation in sequences other than those illustrated or otherwise described herein.", "Similarly, if a method is described herein as comprising a series of steps, the order of such steps as presented herein is not necessarily the only order in which such steps may be performed, and certain of the stated steps may possibly be omitted and/or certain other steps not described herein may possibly be added to the method.", "Furthermore, the terms “comprise,” “include,” “have,” and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements is not necessarily limited to those elements, but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.", "The terms “left,” “right,” “front,” “back,” “top,” “bottom,” “over,” “under,” and the like in the description and in the claims, if any, are used for descriptive purposes and not necessarily for describing permanent relative positions.", "It is to be understood that the terms so used are interchangeable under appropriate circumstances such that the embodiments of the invention described herein are, for example, capable of operation in other orientations than those illustrated or otherwise described herein.", "The term “coupled,” as used herein, is defined as directly or indirectly connected in an electrical or non-electrical manner.", "Objects described herein as being “adjacent to” each other may be in physical contact with each other, in close proximity to each other, or in the same general region or area as each other, as appropriate for the context in which the phrase is used.", "Occurrences of the phrase “in one embodiment” herein do not necessarily all refer to the same embodiment.", "DETAILED DESCRIPTION OF THE DRAWINGS In one embodiment of the invention, a multi-chip package comprises a substrate having a first side, an opposing second side, and a third side that extends from the first side to the second side, a first die attached to the first side of the substrate and a second die also attached to the first side of the substrate, and a bridge adjacent to the third side of the substrate and attached to the first die and to the second die.", "No portion of the substrate is underneath the bridge.", "The bridge creates a connection between the first die and the second die.", "Alternatively, the bridge may be disposed in a cavity in the substrate or between the substrate and a die layer.", "The bridge may constitute an active die and may be attached to the substrate using wirebonds.", "Shrinking die sizes coupled with increasing die performance requirements dictate that the density of the corresponding die-to-die interconnects must be increased.", "As may be expected, several manufacturing issues must be addressed in order to accomplish this goal.", "One such issue is the difficulty inherent in fabricating interconnects within an organic substrate material.", "In order to overcome this problem, a silicon interposer sandwiched between the dies and the package substrate has been proposed.", "The use of a standard copper damascene process allows fabrication of lines and spaces of submicron dimensions.", "However, the large silicon interposer area and need for through-silicon vias (TSVs) make this approach an expensive one, thus negating the perceived MCP-derived cost benefits.", "Embodiments of the invention enable density scaling of interconnect structures that represents an accelerated improvement over existing technology generations by making use of silicon bridges (or bridges made of other materials) that are embedded in or attached to the package substrate.", "These bridges need to support only the dense die-to-die interconnect from die edge to die edge and can consequently be much smaller than a silicon interposer.", "The silicon bridge concept also eliminates the need for TSV technology.", "In addition to greatly increased communication bandwidth due to high density interconnect structures, embodiments of the invention may also enable improved assembly processes due (at least in part) to the maturity of silicon process technology.", "Certain embodiments of the invention may enable the fabrication of MCPs having unprecedented die-to-die interconnect densities that would in turn enable MCP-type cost savings, modularity, and architectural flexibility.", "Examples of such potential benefits include improved reticle and wafer utilization by die aspect ratio optimization, the ability to combine within a single package dies using different optimized silicon (or other) processes or dies incorporating differing or incompatible design methodologies, the potential to assemble non-rectangular or large “super-dies,” the ability to combine dies or die stacks with differing heights, and others.", "Embodiments of the invention also enable the precise alignment of bridges, including silicon bridges, to a package substrate.", "Such alignment may be important in the creation of an overall well-defined bump field for subsequent die attach, especially in view of the high interconnect densities targeted on the silicon bridges.", "Furthermore, an on-die type density may allow reuse of existing circuit designs with minimal modification, and many available pins at the die-package interface may enable simple protocols and good input/output (I/O) power efficiency.", "Some embodiments of the invention make use of a hybrid flip-chip/wirebond assembled active “satellite” die (or dies) where the die is flip-chip connected to at least one processing unit die and is also connected by wirebond directly to the package substrate.", "The processing unit die is assembled to the package substrate using flip-chip interconnects.", "The flip-chip interconnects between the satellite die and the processing unit die enable high-density, high-speed communication between the satellite die and the processing unit die and also (where multiple processing unit dies are involved) allow the satellite die to play the role of a high-speed silicon bridge enabling high-speed, high-density connectivity between two or more processing unit dies in addition to providing the active functionality of the satellite die to one or more of the processing unit dies.", "The wirebond connections to the satellite die allow for power delivery to that die and further allow additional I/O or control signal connectivity apart from that provided by the flip chip connections to the processing unit die(s).", "As with the embodiments described above, TSVs are avoided altogether.", "Referring now to the drawings, FIGS.", "1A, 1B, and 1C are plan views of a multi-chip package 100 according to various embodiments of the invention and FIG.", "2 is a cross-sectional view, taken at a line 2-2 in FIG.", "1C, of multi-chip package 100 according to an embodiment of the invention.", "(Views of corresponding cross sections of FIGS.", "1A and 1B would be very similar or identical to the cross section depicted in FIG.", "2.)", "As illustrated in FIGS.", "1A-1C and FIG.", "2, multi-chip package 100 comprises a substrate 110 having a side 111, an opposing side 112, and a side 213 that extends from side 111 to side 112.Multi-chip package 100 further comprises a die 120 and a die 130, both of which are attached to side 111 of substrate 110, and a bridge 140 adjacent to side 213 of substrate 110 and attached to die 120 and to die 130.As illustrated, and as further discussed below, no portion of substrate 110 is underneath bridge 140 such that there is an unobstructed path to dies 120 and 130 through or along substrate 110 for bridge 140.Bridge 140 creates a connection (e.g., an electrical or optical connection or the like) between die 120 and die 130 by matching electrically and/or optically conductive traces running through the bridge with pads or other interconnect structures on the dies.", "In certain embodiments, as mentioned above, bridge 140 comprises silicon.", "Silicon bridges are used because silicon process technology is relatively advanced, and interconnect pitches and line widths that are achievable using existing silicon process technology are significantly smaller than what is possible using, for example, currently available technology for copper lines in polymer layers.", "Thus die-to-die interconnects may be constructed with much greater density when silicon bridges are used than when such interconnects are fabricated within typical organic substrate materials.", "Speaking generally, embodiments of the invention employ silicon bridges with high density solder bumps and fine lines, with the latter being made using traditional silicon processes.", "In some embodiments, bridge 140 can be a passive component, in that it has no functionality other than to provide a high-speed, high-density signaling pathway between dies 120 and 130.In other embodiments, bridge 140 comprises an active die, having its own functionality apart from a bridging function, that constitutes a third die (die 120 and die 130 being the first two) of multi-chip package 100.In such embodiments, bridge 140 could have a design enabled for hybrid assembly, such as having both bumps for flip-chip interconnects and pads for wirebond connections prepared on the same side (surface) of the active die.", "Furthermore, such embodiments could reduce manufacturing expenses.", "For example, a processing unit die requiring on-package external memory in addition to connectivity with another processing unit die could be served by a single bridge die having fast local memory functionality, thus eliminating the need for any additional components, as such a bridge would provide both functions.", "As an example, the active die can be an active silicon die, or the active die can comprise other semiconducting materials such as gallium arsenide (GaAs), silicon germanium (SiGe), or any other suitable semiconducting material or combination of semiconducting materials.", "Although this description will from time to time make reference to an “active silicon die,” it should be understood that active dies of any suitable semiconducting material or combination of materials are also contemplated.", "It should also be understood that what are referred to herein as active dies, no matter what material or materials they are made of, have their own functionality apart from their ability to act as a bridge and provide connections between other dies.", "In the illustrated embodiments, the intersection of side 111 and side 213 creates an edge 117.In FIG.", "1A, edge 117 is an internal substrate edge because it lies along an inside perimeter of substrate 110.In contrast, edge 117 in FIGS.", "1B and 1C is an external substrate edge because it lies along an outside perimeter of substrate 110.In the latter embodiment (FIGS.", "1B and 1C), side 213 constitutes a portion of an outside perimeter of substrate 110, i.e., a perimeter that circumscribes all of substrate 110, while in the former embodiment (FIG.", "1A) side 213 constitutes a portion of an inside perimeter of substrate 110, i.e., a perimeter that circumscribes an internal feature of substrate 110, such as an aperture 119, but does not circumscribe all of substrate 110.As illustrated, dies 120 and 130 are arranged such that they overhang an internal or an external edge of substrate 110: a portion 221 of die 120 overhangs edge 117 and, similarly, a portion 231 of die 130 overhangs edge 117.As suggested above, die overhang at an internal substrate edge implies substrate 110 has an aperture, such as aperture 119.In at least some embodiments this aperture is slightly larger than bridge 140.In cases where multiple bridges are desired multiple apertures may be provided, or smaller apertures can be combined into a larger aperture accommodating multiple bridges, depending on design requirements.", "Overhang at an external substrate edge implies that dies 120 and 130 are mounted near the package substrate periphery, as discussed above and as illustrated in FIG.", "1B.", "In certain cases, however, the overhang amount may be greater than desired, which can negatively impact I/O routing, power delivery, thermal management, and the like.", "These issues may possibly be overcome by using a slotted package substrate such as that shown in FIG.", "1C.", "It may be seen in FIG.", "2 that the portions of dies 120 and 130 that overhang edge 117 (and that are connected to bridge 140), i.e., portions 221 and 231, respectively, contain interconnect structures having a much smaller pitch than do the interconnect structures at the non-overhanging portions of dies 120 and 130.This is consistent with what has been said above regarding the pitches that are achievable both within and outside of bridge 140.In one embodiment, the fine-pitch interfaces (i.e., those contained in portions 221 and 231) are formed separately from the coarse-pitch interfaces at the non-overhanging portions of dies 120 and 130.Regarding these interconnect structures, it should be mentioned that those described herein as having a “fine pitch” do not necessarily all have the same pitch as each of the other “fine pitch” interconnect structures, nor do all of the “coarse pitch” interconnect structures necessarily have the same (coarser) pitch as each of the other “coarse pitch” interconnect structures.", "Rather, each of the “fine pitch” interconnect structures have, in general, a pitch that is finer than any of the “coarse pitch” interconnect structures, but individual pitch variations may exist from one interconnect structure to another.", "Electrical signaling analysis for dense die-to-die interconnects for silicon bridges has shown that signaling without repeaters is possible at relevant densities and over lengths required (e.g., up to two millimeters).", "Additionally, in at least one embodiment, some or all of these interconnect structures may comprise flip-chip or controlled collapse chip connect (C4) connections.", "(The “flip-chip” and “C4” labels are used interchangeably herein.)", "Because such connections are well known in the art the details of their structure and manufacture will not be discussed herein except to say that the manufacture is transparent to the particular technology used (whether reflow, thermocompression bonding, or some other process).", "For reasons discussed below, in some embodiments (such as, for example, where bridge 140 is an active silicon die), bridge 140 is attached to substrate 110 using wirebonds 241.", "(These wirebonds have been omitted from FIGS.", "1A-1C in order to increase the clarity of those figures.)", "Only a portion of wirebonds 241 are shown in FIG.", "2 because the perspective of that figure makes it difficult to depict the full extent of the wirebonds.", "It should be understood, however, that wirebonds 241 continue in an unbroken path from bridge 140 to substrate 110 in order to create an electrical connection between bridge 140 and substrate 110.As mentioned above, no TSVs are needed in bridge 140 or for the other bridges/satellite dies described herein.", "The satellite dies are connected to the processing unit dies using flip-chip (face-to-face) connections in order to allow for interfacing the processing unit and satellite die I/O and for providing an interface (where desired) for die-to-die bridge functionality.", "All or some of the other (slower) I/Os of the satellite die and its power and ground connects are, in certain embodiments, supplied by wirebonds.", "This represents a possible cost savings.", "An advantage of using wirebonding to supply the I/O and power and ground connections, rather than supplying such connections through a connected processing unit die, is that the processing unit dies would not then need the infrastructure required to provide power and additional I/Os that are not needed for the processing unit die itself, which additional infrastructure and associated overhead would likely increase the processing unit die area and significantly increase the processing unit cost.", "Also, if used without a satellite die this additional infrastructure in the processing unit would be wasted.", "FIG.", "3 is a flowchart illustrating a method 300 of providing die-to-die interconnects in a multi-chip package according to an embodiment of the invention.", "As an example, method 300 may represent a portion of a manufacturing process that results in the formation of a multi-chip package that is similar to multi-chip package 100 as shown in FIGS.", "1A, 1B, 1C, and 2.Although these figures depict a single bridge connecting two dies, other embodiments of the invention may involve more than two dies and/or more than a single bridge.", "A step 310 of method 300 is to provide a substrate having a first side, an opposing second side, and a third side that extends from the first side to the second side.", "As an example, the substrate can be similar to substrate 110, and the first side, the second side, and the third side can be similar to, respectively, side 111, side 112, and side 213 of substrate 110.Sides 111 and 112 are first shown in FIG.", "1A, and side 213 is shown in FIG.", "2.In one embodiment, step 310 comprises forming an aperture through the substrate such that the third side constitutes a portion of an inside perimeter of the substrate.", "As an example, this embodiment may result in an MCP such as that shown in FIG.", "1A.", "In another embodiment, step 310 comprises forming a slot in the substrate such that the third side constitutes a portion of an outside perimeter of the substrate.", "As an example, this embodiment may result in an MCP such as that shown in FIG.", "1C.", "Either of these embodiments may be characterized by a lower cost than that likely required for a bridge embedded in a substrate cavity as described elsewhere herein.", "Indeed, in cases where coreless substrates or other thin substrates are to be used such embodiments may be the only viable option.", "As an example, apertures or slots such as those discussed above may be formed by mechanical or laser drilling, milling, routing, stamping, punching, etching, or the like.", "A step 320 of method 300 is to attach a first die to the first side of the substrate such that a portion of the first die extends beyond an edge of the first side of the substrate.", "As an example, the first die can be similar to die 120 that is first shown in FIG.", "1A.", "As another example, the edge of the first side of the substrate can be similar to edge 117, and the portion of the first die that extends beyond the edge can be similar to portion 221 of die 120, which portion is first shown in FIG.", "2.A step 330 of method 300 is to attach a second die to the first side of the substrate such that a portion of the second die extends beyond the edge of the first side of the substrate.", "As an example, the second die can be similar to die 130 that is first shown in FIG.", "1A.", "As another example, the portion of the second die that extends beyond the edge can be similar to portion 231 of die 130, which portion is first shown in FIG.", "2.In one embodiment, steps 320 and 330 may be combined into a single step.", "In the same or another embodiment the die attachment of steps 330 and 320 (or of the single step that combines the two) comprises an alignment function facilitated by solder self-alignment.", "Note that in an embodiment such solder self-alignment occurs during the coarse-pitch MCP die attach step or steps and the dies may be precisely positioned with respect to each other by virtue of a single lithographically defined solder mask pattern on the first side of the substrate.", "A step 340 of method 300 is to provide a bridge containing a plurality of electrically and/or optically conductive features.", "As an example, the bridge can be similar to bridge 140 that is first shown in FIG.", "1A.", "Accordingly, in some embodiments the bridge can be an active silicon die.", "As another example, the electrically conductive features can be metal traces or the like as known in the art that are suitable for conducting electricity between one region and another, or one component and another, of an MCP, while the optically conductive features can be, for example, optical waveguides such as silicon nitride waveguides, rib waveguides, and the like, or optical coupling elements such as gratings, micro-mirrors, and lenses.", "A step 350 of method 300 is to position the bridge adjacent to the third side of the substrate such that no portion of the substrate is underneath the bridge.", "This arrangement allows for a mechanical decoupling of the bridge and the substrate—materials that have a large mismatch in coefficient of thermal expansion (CTE).", "Furthermore, an unconstrained bridge could offer package stress benefits because it could move without creating a bending load on the fine-pitch joints.", "Thus, method 300 may not require the use of an underfill or encapsulant to fill the space around the bride in the aperture or slot or the like.", "As an example, step 350 may be accomplished using a pick and place machine, as known in the art.", "A step 360 of method 300 is to attach the bridge to the first die and to the second die, thereby creating an electrical or optical connection between the first die and the second die.", "Accordingly, step 360 may constitute an attachment from the backside of the package, i.e., method 300 may constitute a “bridge last” process flow.", "It should be noted that because no portion of the substrate is underneath the bridge, this “bridge last” process flow may allow the use of a full-thickness bridge (unless thermomechanical considerations indicate bridge thinning to be advantageous for fine-pitch interconnect reliability, or unless thinning is needed for form factor or mechanical clearance) where other process flows would require that a thinned bridge be used.", "Also, the “bridge last” process flow enables the building of MCPs with dies or die stacks of disparate heights without any modification to the outlined assembly flow while also providing a scaleable solution that enables affordable assembly of multiple bridges in a given MCP configuration.", "In one embodiment, step 360 may be accomplished using a thermocompression bonding process.", "In another embodiment, step 360 comprises using a solder reflow process.", "As is known in the art, in thermocompression bonding temperature and pressure may be controlled; with a solder reflow process only the temperature may be controlled.", "As is also known, solder reflow is a high-throughput batch process.", "Thermocompression bonding is typically a sequential process; however, a “ganged” bonder can process several units at once.", "Thermocompression bonding may in certain embodiments be needed to achieve the fine-pitch interconnect because of its process flexibility and its better control of process parameters.", "A step 370 of method 300 is to attach the bridge to the substrate using a wirebond.", "As an example, the wirebond can be similar to wirebonds 241 that are shown in FIG.", "2.Step 370 may be performed, for example, in embodiments where the bridge is an active die.", "It should be understood, however, that step 370 is not necessarily performed in every embodiment of method 300.FIG.", "4 is a flowchart illustrating a method 400 of providing die-to-die interconnects in a multi-chip package according to another embodiment of the invention.", "Method 400 is an assembly process enabling the precise alignment of bridges to MCP dies first, followed by the attachment of bridge and dies to a package substrate.", "This subsequent attachment of bridge and dies to the package substrate may be easier in the bridge-to-dies first process because it eliminates certain issues typically caused by mixed bump, fine pitches.", "Method 400 may also be employed, for example, when a substrate with a cutout cannot be provided and when an overhang over an external substrate edge is not an option due to design considerations.", "Method 400 and a multi-chip package 500 related thereto are further illustrated in FIGS.", "5-8, which are cross-sectional views of multi-chip package 500 at various particular points in its manufacturing process according to embodiments of the invention.", "As explained in further detail below, method 400 generally involves the attachment of dies to a carrier, fine pitch assembly of one or more bridges to the dies, coarse pitch assembly of the carrier, dies, and bridge(s) to a package substrate, and (optionally) de-bonding of the carrier.", "Potential advantages of this method over one or more of the other methods or embodiments described herein are that it eliminates the package substrate as a mechanical reference in the mixed-bump-pitch assembly flow, and that it forms the fine-pitch and coarser-pitch interconnects in separate steps.", "Furthermore, method 400 permits accurate bridge alignment in three dimensions.", "As stated above, accurate bridge alignment may be important in order to create an overall well-defined bump field for subsequent die attach.", "High interconnect densities accentuate this requirement.", "A step 410 of method 400 is to attach a first die and a second die to a carrier.", "When placing the dies, suitable fiducials on previously placed dies or on other components of the subassembly, such as the carrier, may be used as a reference.", "As an example, the first die and the second die can be similar to, respectively, die 120 and die 130 that are first shown in FIG.", "1A.", "As another example, the first die and the second die can be similar to, respectively, a die 520 and a die 530 that are first shown in FIG.", "5.Attached to die 520 are fine-pitch interconnect structures 521 and coarse-pitch interconnect structures 522.Attached to die 530 are fine-pitch interconnect structures 531 and coarse-pitch interconnect structures 532.More specifically, and as illustrated in FIG.", "5 and subsequent figures, die 520 has a portion 526 containing interconnect structures 521 and a portion 527 containing interconnect structures 522.Similarly, die 530 has a portion 536 containing interconnect structures 531 and a portion 537 containing interconnect structures 532.As mentioned above, interconnect structures 521 and 531 have a first (fine) pitch and interconnect structures 522 and 532 have a second (coarse) pitch that is different from the first pitch.", "It may be seen that, as already mentioned elsewhere herein, portions 526 and 536 are attached to the bridge (by way of fine pitch interconnect structures 521 and 531).", "Note that interconnect structures 521 and 531 would typically be silicon to silicon structures rather than silicon to organic structures.", "As an example, this may help to forestall the problems that are typically associated with a mismatch in the CTE between the two materials.", "The carrier can be similar to a carrier 505 that is first shown in FIG.", "5.In one embodiment, the carrier comprises an integrated heat spreader (IHS).", "As an example, the heat spreader may be made of copper or the like.", "Due to the high thermal conductivity of the copper (or other) IHS, the package may be thermally enhanced.", "In the embodiment of FIG.", "5, dies 520 and 530 are attached to carrier 505 using an adhesive material 507, which may comprise a thermal interface material (TIM) or the like.", "A step 420 of method 400 is to attach a bridge to the first die and to the second die.", "Note that in this step only the fine pitch interconnect structures are attached.", "The small bump pitch may require highly accurate pick-and-place equipment.", "Again, on-die fiducials may be useful for achieving successful bonding.", "As an example, the bridge can be similar to bridge 140 that is first shown in FIG.", "1A.", "As another example, the bridge can be similar to a bridge 540, first shown in FIG.", "5, that, like bridge 140, may be made of silicon and may, further, be an active silicon die.", "In one embodiment, step 420 comprises using a thermocompression bonding process to bond the bridge and the dies to each other.", "In other embodiments, step 420 comprises using a solder reflow process or another attachment procedure as known in the art.", "A step 430 of method 400 is to provide a substrate.", "As an example, the substrate can be similar to substrate 110 that is first shown in FIG.", "1A.", "As another example, the substrate can be similar to a substrate 610 that is first shown in FIG.", "6.Substrate 610 contains a cavity 615 that, in the illustrated embodiment, contains bridge 540 surrounded by a protective material 612 such as an encapsulant, an underfill material, an epoxy, or the like.", "Material 612 may be compliant or flexible in order to mechanically decouple bridge 540 and substrate 610, and its presence may enable undisturbed underfilling of dies 520 and 530.As still another example, the substrate can be similar to a substrate 710 that is first shown in FIG.", "7.In the FIG.", "7 embodiment, dies 520 and 530 form, or are located in, a die layer 750 of multi-chip package 500.Substrate 710 has no cavity; a bridge 740, which is significantly thinner than bridge 540, sits on a surface of substrate 710 or is otherwise located between substrate 710 and dies 520 and 530—in other words, bridge 740 is located between die layer 750 and the surface of the substrate.", "(In other respects bridge 740 can be similar to bridges 540 and 140 and can therefore, in certain embodiments, be an active die.)", "Also in the FIG.", "7 embodiment, one or more of interconnect structures 521, 522, 531, and 532 may need to be modified in order to accommodate the reduced thickness of bridge 740.For example, interconnect structures 521 and 531 may need to be shortened while interconnect structures 522 and 532 may need to be lengthened in order to accommodate the different package geometry.", "As with other embodiments described herein, one or more of interconnect structures 521, 522, 531, and 532 may comprise flip-chip connections.", "It should be noted that bridge 740 may be thin enough that it requires its own carrier in order to facilitate handling, e.g.", "before and during step 420 of method 400.A step 440 of method 400 is to attach the first die and the second die to the substrate.", "In this step only the die bumps with a large pitch (outside the bridge area) are attached.", "Since the bump pitch is large, less expensive pick-and-place equipment can typically be used.", "The appearance of multi-chip package 500 following the performance of step 440 is illustrated in FIG.", "6 for an embodiment using substrate 610 and in FIG.", "7 for an embodiment using substrate 710.In some embodiments, step 440 is followed by the removal of the carrier.", "As an example, this may be accomplished by peeling, cutting, etching away, or melting the adhesive material, or otherwise de-bonding the carrier from the dies.", "FIG.", "8 shows multi-chip package 500 following the removal of carrier 505.Carrier 505 in FIG.", "7 may also be removed (not illustrated).", "In other embodiments, such as when the carrier is a heat spreader, step 440 is not performed and the carrier is permanently left in place.", "In yet another embodiment (not illustrated), in order to accommodate dies of different thicknesses, a mix of single dies and die stacks, or die stacks of different heights, the carrier or IHS may be stepped such that before bridge-to-die attach the bumps to be interconnected by an individual bridge are coplanar.", "Suitable steps or cavities can be created by machining the carrier or IHS.", "A step 450 of method 400 is to attach the bridge to the substrate using a wirebond.", "As an example, the wirebond can be similar to wirebonds 241 that are shown in FIG.", "2 or to wirebonds 841 that are shown in FIG.", "8.", "(The embodiment of FIG.", "7 may also include wirebonds, or in other words bridge 740 may also, in certain embodiments, be connected to substrate 710 using wirebonds.", "Such wirebonds are not depicted in FIG.", "7, however, because the presence in that figure of carrier 505 combined with the figure's cross-sectional nature make it difficult to illustrate the wirebonds clearly, or because the wirebonds are added after the removal of carrier 505.)", "Only a portion of wirebonds 841 are shown in FIG.", "8 because the perspective of that figure makes it difficult to depict the full extent of the wirebonds.", "It should be understood, however, that wirebonds 841 continue in an unbroken path from bridge 540 to substrate 610 in order to create an electrical connection between bridge 540 and substrate 610.Step 450 may be performed, for example, in embodiments where the bridge is an active die.", "It should be understood, however, that step 450 is not necessarily performed in every embodiment of method 400.FIG.", "9 is a cross-sectional view of a multi-chip package 900 according to an embodiment of the invention.", "As illustrated in FIG.", "9, multi-chip package 900 comprises a substrate 910 containing a cavity 915 having a plurality of pads 918 therein, a die 920 and a die 930 attached to substrate 910, a bridge 940 having a side 941 and an opposing side 942, and a plurality of joints 960 at side 942 of bridge 940.As an example, pads 918 and joints 960 can be electrically non-functional.", "Pads 918 may be prefabricated during conventional build-up processes and then exposed during cavity formation, for example by laser milling or the like.", "An encapsulation material 945 at least partially surrounds bridge 940 in cavity 915 in the illustrated embodiment.", "As an example, substrate 910, die 920, die 930, and bridge 940 can be similar to, respectively, substrate 110, die 120, die 130, and bridge 140, all of which are first shown in FIG.", "1A.", "Accordingly, in certain embodiments bridge 940 can be an active die.", "As may be seen in the figure, die 920 and die 930 are attached to side 941 of bridge 940, at least a portion of bridge 940 is located within cavity 915 such that the plurality of j oints 960 are aligned with pads 918, and bridge 940 creates an electrical or optical connection between die 920 and die 930.Die 920 has a portion 926 containing a plurality of interconnect structures 921 and a portion 927 containing a plurality of interconnect structures 922.Similarly, die 930 has a portion 936 containing a plurality of interconnect structures 931 and a portion 937 containing a plurality of interconnect structures 932.Interconnect structures 921 and 931 have a first (fine) pitch and interconnect structures 922 and 932 have a second (coarse) pitch that is different from the first pitch.", "Portions 926 and 936 are attached to the bridge (by way of fine pitch interconnect structures 921 and 931).", "As has been discussed elsewhere herein, in some embodiments, such as, for example, where bridge 940 is an active die, bridge 940 is attached to substrate 910 using wirebonds.", "These wirebonds have not been depicted in FIG.", "9 because the nature of that figure makes such depiction difficult.", "It should be understood, however, that, in a manner similar to what is shown in other figures described herein, the wirebonds continue in an unbroken path from bridge 940 to substrate 910 in order to create an electrical connection between bridge 940 and substrate 910.FIG.", "10 is a flowchart illustrating a method 1000 of providing die-to-die interconnects in a multi-chip package according to an embodiment of the invention.", "As an example, method 1000 may represent a portion of a manufacturing process that results in the formation of a multi-chip package that is similar to multi-chip package 900 as shown in FIG.", "9.As explained in further detail below, method 1000 generally involves providing a package substrate, machining or otherwise forming a cavity for a silicon or other bridge, dispensing flux onto cavity floor pads, pick and place of the bridge with backside solder bumps, solder reflow with solder self-alignment of the bridge, deflux (unless a no-clean flux or fluxless attachment process is used), encapsulation of bridge, and assembly of active dies.", "A potential advantage of this process is that it is readily scalable to multiple bridges on a package and many substrates on a panel.", "A step 1010 of method 1000 is to provide a substrate having a plurality of embedded pads.", "As an example, the substrate and the pads can be similar to, respectively, substrate 910 and pads 918 that are shown in FIG.", "9.A step 1020 of method 1000 is to form a cavity in the substrate such that the pads are exposed at a floor of the cavity.", "As an example, the cavity can be similar to cavity 915 that is shown in FIG.", "9.In one embodiment, step 1020 may be accomplished using a laser milling process, a plasma etching/reactive ion etching (RIE) process, or the like.", "As cavity 915 is formed, electrically non-functional (dummy) or other pads 918 at the cavity floor are exposed.", "In one embodiment, these were previously fabricated during the conventional substrate buildup process and were buried by one or more dielectric buildup layers.", "Pads 918 may be made of copper and present a suitable surface finish such as electroless nickel, immersion gold (ENIG), conducive to soldering.", "A minimum pad thickness of approximately 10 μm may be desirable when laser milling is used for cavity formation, with the laser operation to stop at the pad layer.", "Mating pads may be provided on the backside of bridge 940 and the bridge may be bumped ahead of time using standard metallization and bumping techniques, perhaps at the wafer level.", "A solder resist layer may also be added to the backside of bridge 940.A step 1030 of method 1000 is to provide a bridge having bumps thereon corresponding to the pads.", "(Such correspondence between bumps and pads may, but does not necessarily, mean the number of bumps and the number of pads are equal to each other; rather, the correspondence is such that the bumps match up with the pads to the degree that a reliable mechanical joining is possible.)", "As an example, the bridge can be similar to bridge 940, shown in FIG.", "9, and can thus in certain embodiments be an active die, and the joints formed can be similar to joints 960, also shown in FIG.", "9.A step 1040 of method 1000 is to place the bridge in the cavity and align the bumps and the pads to each other.", "Step 1040 attaches the bridge to the substrate.", "In one embodiment, the alignment of bumps and pads to each other is accomplished using the self-alignment of solder during reflow and joint formation.", "Solder self-alignment of electronic components where the surface tension of the liquid solder is the driving force is well known in the art.", "Careful design of a solder joint array can provide self alignment in the x and y dimensions with a positional tolerance in the order of 1 micrometer (hereinafter “micron” or “μm.”) Accurate alignment in the z dimension (height) can be achieved by control of the solder volume.", "The precisely aligned bridge may then be encapsulated, thereby locking the bridge at its precisely defined locations.", "The resulting hybrid package substrate may then be supplied to a die attach module.", "A step 1050 of method 1000 is to provide a first die and a second die.", "As an example, the first die and the second die can be similar to, respectively, die 920 and die 930, both of which are shown in FIG.", "9.A step 1060 of method 1000 is to attach the first die and the second die to the bridge and the substrate.", "In one embodiment, step 1060 comprises a flux dispense step, die pick-and-place steps, and a reflow step.", "As mentioned elsewhere herein, at very high I/O densities and very fine bridge interconnect pitches, accurate alignment becomes important in order to facilitate a successful assembly of the MCP (die attach).", "Thus, in certain embodiments, and as shown in FIG.", "9, joints 960 located at the backside (i.e., side 942) of bridge 940 are utilized to achieve precise alignment of bridge 940 with respect to other package substrate bumps.", "It is well known that solder self-alignment can enable ultimate component placement in the x and y dimensions with a positional tolerance on the order of 1 μm.", "As an alternative to solder, suitable non-conductive materials that are capable of providing self-alignment based on the underlying surface tension principle (minimization of adhesion energy during bonding) could also be used.", "A step 1070 of method 1000 is to attach the bridge to the substrate using a wirebond.", "As an example, the wirebond can be similar to wirebonds 241 that are shown in FIG.", "2 or to wirebonds 841 that are shown in FIG.", "8.Step 1070 may be performed, for example, in embodiments where the bridge is an active die.", "It should be understood, however, that step 1070 is not necessarily performed in every embodiment of method 1000.FIG.", "11A is a plan view of a multi-chip package 1100 according to an embodiment of the invention.", "Cross-sectional views for two different embodiments of multi-chip package 1100, each taken at a line B-C in FIG.", "11A, are shown in FIGS.", "11B and 11C.", "As illustrated in FIGS.", "11A-11C, multi-chip package 1100 comprises a substrate 1110, an active die 1120 attached to substrate 1110 using flip-chip connections 1121 (in FIG.", "11A these are visible in a portion 1125 of active die 1120 that is depicted (for illustrative purposes) as being transparent), and an active die 1130, which is attached to active die 1120 using a flip-chip connection 1131 and which is attached to substrate 1110 using wirebonds 1141.As may be seen in the figure, multi-chip package 1100 is an example of an embodiment where a satellite die assembled in a hybrid manner is attached to a single on-package (processing unit) die.", "Such an arrangement allows for high-density, high-speed flip-chip connectivity between the processing unit and the satellite die and further allows for the processing unit die to utilize the functionality of the satellite die.", "In cases where high-density interconnects are not needed (e.g., because of the functionality of the satellite die), the flip-chip interconnects may have a relatively coarse pitch.", "Additional connections needed by the satellite die such as, but not limited to, power and ground connectivity, may be provided by wirebonds located on sides of the satellite die not obscured by the processing unit die.", "In certain embodiments substrate 1110 contains a cavity in which active die 1130 is at least partially located.", "Such a cavity is visible in FIG.", "11B and examples may also be seen in FIGS.", "6, 8, and 9.In other embodiments, (see FIG.", "11C) substrate 1110 has a first side, an opposing second side, and a third side that extends from the first side to the second side (not identified with reference numerals in FIG.", "11C, but such as may form an aperture or slot as discussed above), active die 1120 is attached to the first side of substrate 1110 using flip-chip connections 1121, active die 1130 is attached to substrate 1110 using wirebonds 1141, and no portion of substrate 1110 is underneath active die 1130.These embodiments are similar to those described in connection with FIGS.", "1A-1C and FIG.", "2.In each of these cases, such cavities, apertures, slots, and the like that house the satellite dies may partially overlap with the bump field of the processing unit dies in order to enable flip-chip, high-speed, high-density connections between satellite die and processing unit die as described herein.", "Active die 1130 has a region 1138 and a region 1139, where region 1138 is an overlap region located between active die 1130 (below) and a portion of active die 1120 (above).", "As shown, the overlap region can be a partial overlap of active dies 1120 and 1130 such that the lower die is not completely underneath the upper die.", "The overlap region may be the location of one or more face-to-face flip-chip connections that electrically or optically connect the active dies to each other.", "Referring again to the illustrated embodiment, flip-chip connection 1131 is located in region 1138 while wirebonds 1141 are attached to active die 1130 in region 1139.In the illustrated embodiment, active die 1130 is attached to substrate 1110 using wirebonds 1141.Note that one edge of active die 1130 is shown as having a double row of wirebonds.", "In some (non-illustrated) embodiments three or more wirebond rows may be fabricated.", "Such multiple rows, however, may not achieve the same fine pitches that are achievable with single rows, which may be as small as a pad pitch of 35 μm (corresponding to approximately 29 bonds/mm die edge).", "For power and ground connections, minimum pitch wirebond capability may not be needed and a thicker bond wire at a lower pitch may be acceptable or even favorable.", "It should be understood that the illustration, like all of the illustrations referred to herein, is not intended to be limiting, and that non-illustrated embodiments may employ more or fewer double wirebond rows (including embodiments having no such rows), one or more sections having more than two wirebond rows, longer or shorter rows having more or fewer wirebonds, wirebonds along only certain sides but not all sides of the active die, or any other useful wirebond configuration.", "In one embodiment, active die 1120 is a processing unit die such as a central processing unit (CPU), a graphics processing unit (GPU), or the like, while active die 1130 is a satellite die with functionality such as memory (including volatile memory such as fast DRAM, external SRAM, eDRAM, and the like and non-volatile memory such as flash memory and the like), graphics processing, voltage regulation for power delivery, radio frequency (RF), or the like, including useful combinations thereof.", "A satellite die according to various embodiments could even be a microelectromechanical system (MEMS) chip, a sensor chip for use in a system-on-package (SoP), or a photonics die with optoelectronic functionality.", "Active die 1130 is sometimes referred to herein as a satellite die because it is connected to, and may share active functionality with, active die 1120.In certain embodiments, active die 1130 may also be connected to and share active functionality with one or more other dies (not illustrated in FIGS.", "11A-11C) in addition to active die 1120.In cases where the satellite die is connected to more than one active die the satellite die may or may not electrically or optically connect those active dies to each other, or in other words may or may not act as a bridge between those active dies in a manner that is explained elsewhere herein.", "FIG.", "12 is a plan view of active die 1130 according to an embodiment of the invention.", "The scale of active die 1130 is slightly larger in FIG.", "12 than it is in FIGS.", "11A-11C.", "As illustrated in FIG.", "12, region 1138 of active die 1130 has a section 1201 and a section 1202.Section 1201 contains a plurality of flip-chip connections 1231 having a first density and section 1202 contains a plurality of flip-chip connections 1131 (first introduced in FIG.", "11A) having a second density that is less than the first density.", "The higher-density and lower-density connections can be used as necessary depending on the functionality of active die 1130.In the illustrated embodiment, region 1138 further comprises a section 1203 that contains a plurality of flip-chip connections 1233 having a third density that is also less than the first density and can, in one embodiment, be the same as or substantially similar to the second density.", "The connections in any one or more of sections 1201, 1202, and 1203 can be used to enable active die 1120 access to the functionality of active die 1130, and vice versa.", "In the embodiment of FIG.", "12, section 1201 is located between section 1202 and section 1203, though other configurations are certainly also possible as will be readily apparent to one of ordinary skill in the art.", "For example, active die 1130 may have flip-chip connections of only a single (high) density, only a single (standard or low) density, one section of high density and another of lower density connections, with these arranged in any suitable configuration, etc.", "Also, it should be noted here that any one or more of bridges 140, 540, 740, and 940, in embodiments where those bridges are active dies, could have the features, configurations, functionalities, etc.", "that are described above for active die 1130.Similarly, any one or more of dies 120, 130, 520, 530, 920, and 930 can be similar to active die 1120.It was mentioned above that active die 1130 may be connected to one or more active dies in addition to active die 1120.In some embodiments, as also mentioned, active die 1130 acts as a bridge between active die 1120 and those additional active dies.", "Examples of this are depicted in FIGS.", "1A-1C, FIG.", "2, and FIGS.", "6-9 if the bridges in those figures are assumed to be active dies.", "FIG.", "13 further illustrates a possible configuration for an active bridge or satellite die 1330 according to an embodiment of the invention.", "As illustrated in FIG.", "13, active die 1330 comprises a region 1338 that is similar to region 1138.For example, in the illustrated embodiment region 1338, like region 1138, contains sections 1201, 1202, and 1203, each containing the features and components described above.", "Electrically and/or optically conductive bridge traces 1370, which extend between section 1201 of region 1138 and the corresponding section of region 1338, provide an electrical or optical connection between dies that are bridged by active die 1330.These dies are not shown in FIG.", "13, but would, for example, be attached to active die 1330 using flip-chip connections 1131, 1231, and 1233 in a manner similar to that described above for active die 1120.FIG.", "14 is a flowchart illustrating a method 1400 of providing die-to-die interconnects in a multi-chip package according to an embodiment of the invention.", "As an example, method 1400 may result in an MCP such as that shown in FIG.", "11C.", "(An MCP such as that shown in FIG.", "11B may be formed using a method similar to method 400 or method 1000 with the second die being omitted.)", "A step 1410 of method 1400 is to provide a substrate.", "As an example, the substrate can be similar to substrate 1110 as it is shown in FIG.", "11C.", "A step 1420 of method 1400 is to attach a first active die to the substrate using a first flip-chip connection.", "As an example, the first active die and the first flip-chip connection can be similar to, respectively, active die 1120 and flip-chip connections 1121, both of which are shown in FIGS.", "11A-11C.", "A step 1430 of method 1400 is to attach a second active die to the first active die using a second flip-chip connection.", "As an example, the second active die and the second flip-chip connection can be similar to, respectively, active die 1130 and flip-chip connections 1131, both of which are first shown in FIG.", "11A.", "A step 1440 of method 1400 is to attach the second active die to the substrate.", "In one embodiment, the second active die is attached to the substrate using a wirebond such as wirebond 1141 that are first shown in FIG.", "11A.", "FIG.", "15 is a plan view of a multi-chip package 1500 according to an embodiment of the invention.", "As illustrated in FIG.", "15, multi-chip package 1500 comprises a substrate 1510, an active die 1520 attached to substrate 1510 using flip-chip connections 1521, an active die 1530 attached to active die 1520 using flip-chip connections 1531 and to substrate 1510 using wirebonds 1541, and an active die 1550 attached to substrate 1510 using flip-chip connections 1551 and attached to active die 1530 using flip-chip connections 1552.Active die 1520 is electrically and/or optically connected to active die 1550 via electrically and/or optically conductive bridge traces 1570 located in active die 1530.Active die 1530 thus acts as a bridge connecting active dies 1520 and 1550.In the illustrated embodiment, active dies 1520 and 1550 have regions and sections the same as or similar to those described above in connection with active die 1120 and shown in FIGS.", "11A-11C, with the features located in those regions and sections, and the characteristics of those features, being similar as well.", "In certain embodiments substrate 1510 contains a cavity in which active die 1530 is at least partially located.", "Such a cavity is not visible in FIG.", "15 but examples may be seen in FIGS.", "6, 8, and 9.In other embodiments, substrate 1510 has a first side, an opposing second side, and a third side that extends from the first side to the second side (such as may form an aperture or slot as discussed above), active dies 1520 and 1550 are attached to the first side of substrate 1510, and no portion of substrate 1510 is underneath active die 1530.These embodiments are not explicitly illustrated in FIG.", "15 but are similar to those described in connection with FIGS.", "1A-1C and FIG.", "2.In each of these cases, such cavities, apertures, slots, and the like that house the satellite dies may partially overlap with the bump field of the processing unit dies in order to enable flip-chip, high-speed, high-density connections between satellite die and processing unit die as described herein.", "Some examples of MCP package geometries showing such partial overlaps are shown in FIG.", "16, where the bridge/satellite die is cross-hatched and the processing unit dies are shown plain.", "(Package substrates are not shown in FIG.", "16.)", "It will be understood that the illustrated examples represent only a fraction of the large number of possible configurations.", "FIG.", "17 is a flowchart illustrating a method 1700 of providing die-to-die interconnects in a multi-chip package according to an embodiment of the invention.", "As an example, method 1700 may result in an MCP such as that shown in FIG.", "15.Described below is a “bridge last” process flow similar to that described by method 300.The FIG.", "15 structure may also be manufactured with a substrate having a cavity similar to the substrates shown in FIG.", "8 or 9.Process flows suitable to manufacture such structures may proceed along the lines of methods 400 and 1000, with a third active die as discussed below standing in for the bridge of those methods.", "A step 1710 of method 1700 is to provide a substrate.", "As an example, the substrate can be similar to substrate 1510 that is shown in FIG.", "15.A step 1720 of method 1700 is to attach a first active die to the substrate using a first flip-chip connection.", "As an example, the first active die and the first flip-chip connection can be similar to, respectively, active die 1520 and flip-chip connections 1521, both of which are shown in FIG.", "15.A step 1730 of method 1700 is to attach a second active die to the substrate using a second flip-chip connection.", "As an example, the second active die can be similar to active die 1550 and the second flip-chip connection can be similar to flip-chip connections 1551, both of which are shown in FIG.", "15.A step 1740 of method 1700 is to attach the third active die to the first active die using a third flip-chip connection.", "As an example, the third flip-chip connection can be similar to flip-chip connections 1531 that are shown in FIG.", "15.A step 1750 of method 1700 is to attach the third active die to the second active die using a fourth flip-chip connection.", "As an example, the fourth flip-chip connection can be similar to flip-chip connections 1552 that are shown in FIG.", "15.With the third active die attached to both the first and the second active dies, and because the third active die contains electrically and/or optically conductive bridge traces as described above and shown in FIG.", "15, method 1700 inherently results in the first and the second active dies being electrically and/or optically connected to each other.", "Alternatively, method 1700 could include an additional step that results in such an electrical or optical connection.", "A step 1760 of method 1700 is to attach the third active die to the substrate.", "In one embodiment, step 1760 comprises attaching the third active die to the substrate using wirebonds.", "Although the invention has been described with reference to specific embodiments, it will be understood by those skilled in the art that various changes may be made without departing from the spirit or scope of the invention.", "Accordingly, the disclosure of embodiments of the invention is intended to be illustrative of the scope of the invention and is not intended to be limiting.", "It is intended that the scope of the invention shall be limited only to the extent required by the appended claims.", "For example, to one of ordinary skill in the art, it will be readily apparent that the multi-chip packages and the related structures and methods discussed herein may be implemented in a variety of embodiments, and that the foregoing discussion of certain of these embodiments does not necessarily represent a complete description of all possible embodiments.", "Additionally, benefits, other advantages, and solutions to problems have been described with regard to specific embodiments.", "The benefits, advantages, solutions to problems, and any element or elements that may cause any benefit, advantage, or solution to occur or become more pronounced, however, are not to be construed as critical, required, or essential features or elements of any or all of the claims.", "Moreover, embodiments and limitations disclosed herein are not dedicated to the public under the doctrine of dedication if the embodiments and/or limitations: (1) are not expressly claimed in the claims; and (2) are or are potentially equivalents of express elements and/or limitations in the claims under the doctrine of equivalents." ] ]
Patent_15876080
[ [ "SPREAD SPECTRUM CODED WAVEFORMS IN ULTRASOUND DIAGNOSTICS", "Techniques, systems, and devices are disclosed for ultrasound diagnostics using spread spectrum, coherent, frequency- and/or phase-coded waveforms.", "In one aspect, a method includes synthesizing individual orthogonal coded waveforms to form a composite waveform for transmission toward a biological material of interest, in which the synthesized individual orthogonal coded waveforms correspond to distinct frequency bands and include one or both of frequency-coded or phase-coded waveforms; transmitting a composite acoustic waveform toward the biological material of interest, where the transmitting includes transducing the individual orthogonal coded waveforms into corresponding acoustic waveforms to form the composite acoustic waveform; receiving acoustic waveforms returned from at least part of the biological material of interest corresponding to at least some of the transmitted acoustic waveforms that form the composite acoustic waveform; and processing the received returned acoustic waveforms to produce an image of at least part of the biological material of interest." ], [ "1.An acoustic imaging system, comprising: a waveform generation unit comprising one or more waveform synthesizers and amplifiers coupled to a waveform generator, wherein the waveform generation unit synthesizes a composite waveform comprising individual orthogonal coded waveforms corresponding to distinct frequency bands that are generated by the one or more waveform synthesizers according to waveform information provided by the waveform generator, wherein the individual orthogonal coded waveforms include one or both of frequency-coded or phase-coded waveforms; a transmitter array of transducer elements in communication with the waveform generation unit to transmit acoustic waveforms forming a composite acoustic waveform based on drive signals produced from the individual orthogonal coded waveforms toward a biological material, wherein the transmitter array of transducer elements is partitioned into two or more subarrays such that at least one of the two or more subarrays is individually amplitude weighted and at least one of the two or more subarrays is individually phase weighted for at least one frequency band of the frequency bands corresponding to the transmitted acoustic waveforms and combined, thereby providing enhanced cross-range resolution; a receiver array of transducer elements to receive returned acoustic waveforms returned from at least part of the biological material, wherein the received returned acoustic waveforms correspond to at least some of the transmitted acoustic waveforms of the composite acoustic waveform, wherein the receiver array of transducer elements is partitioned into two or more subarrays such that at least one of the two or more subarrays is individually amplitude weighted and at least one of the two or more subarrays is individually phase weighted for at least one frequency band of the frequency bands corresponding to the received returned acoustic waveforms and combined, thereby providing enhanced cross-range resolution; and a controller unit in communication with the waveform generation unit and the transmitter and receiver arrays, the controller unit including a processing unit to process the received returned acoustic waveforms to produce an image of at least part of the biological material.", "2.The system of claim 1, further comprising: a user interface unit including a display and in communication with the controller unit to display the produced image.", "3.The system of claim 2, wherein the user interface unit includes one or more user interface devices in communication with the controller unit to receive input from an operator of the system.", "4.The system of claim 3, wherein the input includes a mode of operation, including: an ATS-Mode (Artificial Tissue Staining Mode) for imaging biological tissue that enables image color coding based on at least one feature of one or more measured properties that are obtained from the returned acoustic waveforms, or a CAD-Mode (Computer Aided Diagnostic Mode) for imaging biological tissue that uses one or more algorithmic classifiers to classify biological tissue types using at least one feature of one or more measured properties that are obtained from the returned acoustic waveforms.", "5.The system of claim 2, wherein the display of the user interface unit is operable to display a color coded image of the biological tissue based on the classified biological tissue types.", "6.The system of claim 1, further comprising: an array of analog to digital (A/D) converters in communication with the receiver array and the controller unit to convert the received returned acoustic waveforms from analog format to digital format.", "7.The system of claim 2, wherein the transmitter array and the receiver array include the same transducer elements, and the system further comprises: a transmit/receive switching unit in communication with the waveform generation unit and the transmitter and receiver arrays to switch between a transmit mode to transmit the acoustic waveforms and a receive mode to receive the returned acoustic waveforms.", "8.The system of claim 7, wherein the one or more amplifiers of the waveform generation unit are communicatively coupled between the transmit/receive switching unit and the one or more waveform synthesizers to modify the individual orthogonal coded waveforms of the composite waveform.", "9.The system of claim 7, further comprising: an array of analog to digital (A/D) converters in communication with the receiver array and the controller unit to convert the received returned acoustic waveforms from analog format to digital format; and an array of one or more pre-amplifiers configured between the transmit/receive switching unit and the array of A/D converters that modifies the received returned acoustic waveforms.", "10.The system of claim 1, wherein each of the phase-coded waveforms includes a frequency chip phase component that a pseudo-random number." ], [ "<SOH> BACKGROUND <EOH>Ultrasound imaging is an imaging modality that employs the properties of sound waves traveling through a medium to render a visual image.", "Ultrasound imaging has been used as an imaging modality for decades in a variety of biomedical fields to view internal structures and functions of animals and humans.", "Ultrasound waves used in biomedical imaging may operate in different frequencies, e.g., between 1 and 20 MHz, or even higher frequencies.", "Some factors including inadequate spatial resolution and tissue differentiation can lead to less than desirable image quality using conventional techniques of ultrasound imaging, which can limit its use for many clinical applications." ], [ "<SOH> SUMMARY <EOH>Techniques, systems, and apparatuses are disclosed for ultrasound diagnostics using spread spectrum, coherent, frequency- and/or phase-coded waveforms that can exhibit wide instantaneous bandwidth.", "In one aspect of the disclosed technology, a method of creating an image from an acoustic waveform in an acoustic imaging device includes setting a transmit/receive switch in the acoustic imaging device into a transmit mode to transmit an acoustic waveform toward a target, in transmitting the acoustic waveform, synthesizing, in one or more waveform synthesizers, a plurality of substantially orthogonal coded waveforms that form a composite waveform as the transmitted acoustic waveform toward the target, in which each waveform corresponds to a distinct frequency band and the coded waveforms include at least one of frequency-coded waveforms or phase-coded waveforms, setting the transmit/receive switch in the acoustic imaging device into a receive mode to receive a returned acoustic waveform that returns from at least part of the target, converting the received returned acoustic waveform from analog format to digital format as a received composite waveform comprising information of the target, and processing the received composite waveform to produce an image of at least part of the target.", "In another aspect, an acoustic waveform imaging system is provided to include waveform generation unit comprising one or more waveform synthesizers coupled to a waveform generator, wherein the waveform generation unit synthesizes a composite waveform comprising a plurality of substantially orthogonal coded waveforms corresponding to frequency bands that are generated by the one or more waveform synthesizers according to waveform information provided by the waveform generator, the coded waveforms including at least one of frequency-coded waveforms or phase-coded waveforms; a transmit/receive switching unit that switches between a transmit mode and a receive mode; an array of transducer elements in communication with the transmit/receive switching unit that transmits an acoustic waveform based on the composite waveform toward a target and receives a returned acoustic waveform returned from at least part of the target; an array of analog to digital (A/D) converters to convert the received returned acoustic waveform received by the array of transducer elements from analog format to digital format as a received composite waveform comprising information comprising information of the target; a controller unit in communication with the waveform generation unit and the array of A/D converters comprising a processing unit that processes the received composite waveform to produce an image of at least part of the target; and a user interface unit in communication with the controller unit.", "In another aspect, a method of creating an image from an acoustic waveform is provided to include setting a transmit/receive switch into transmit mode; selecting a mode of operation from a plurality of operating modes; synthesizing, in one or more waveform synthesizers, a plurality of substantially orthogonal coded waveforms that form a composite waveform, wherein each waveform corresponds to a distinct frequency band, the coded waveforms including at least one of frequency-coded waveforms or phase-coded waveforms; transmitting an acoustic waveform based on the composite waveform toward a target; setting the transmit/receive switch into receive mode; receiving a returned acoustic waveform returned from at least part of the target; converting the received returned acoustic waveform from analog format to digital format as a received composite waveform comprising information of the target; and processing the received composite waveform to produce an image of at least part of the target.", "In another aspect, a method of creating an image from an acoustic waveform is provided to include combining a plurality of coded waveforms corresponding to different frequency bands to produce a composite waveform comprising substantially orthogonal wave signals at the different frequency bands, the coded waveforms including at least one of frequency-coded waveforms or phase-coded waveforms; using the composite waveform to produce an acoustic probe wave that includes the different frequency bands toward a target; receiving acoustic energy returned from at least part of the target after the acoustic probe wave is sent to the target; converting the received returned acoustic energy into a digital composite waveform comprising information of the target; and processing the received composite waveform to produce an image of at least part of the target.", "In yet another aspect, a device for creating an image from an acoustic waveform is provided to include means for combining a plurality of coded waveforms corresponding to different frequency bands to produce a composite waveform comprising substantially orthogonal wave signals at the different frequency bands, the coded waveforms including at least one of frequency-coded waveforms or phase-coded waveforms; means for using the composite waveform to produce an acoustic probe wave that includes the different frequency bands toward a target; means for receiving acoustic energy returned from at least part of the target after the acoustic probe wave is sent to the target; means for converting the received returned acoustic energy into a digital composite waveform comprising information of the target; and means for processing the received composite waveform to produce an image of at least part of the target.", "The subject matter described in this patent document can provide one or more of the following features and be used in many applications.", "For example, the disclosed technology can be used during routine primary care screenings to identify and locate early stage malignancies, as well as later stage cancers, which can potentially raise survival rates of hard to diagnose asymptomatic patients.", "The disclosed technology can be used by board certified radiologists to diagnose neoplasms as benign or malignant prior to any surgical biopsy or resection intervention, which may also improve patient survival rate while reducing unnecessary biopsies.", "The disclosed technology can, when integrated with a fine needle biopsy instrument, be used in medical procedures to confirm noninvasive diagnoses, which can reduce the level of invasiveness of such biopsy procedures.", "The disclosed technology can, when integrated with minimally invasive surgical high definition video instrumentation, fuse optical and ultrasound images, which can further give surgeons added abilities to locate and surgically excise diseased tissue without excising excessive healthy tissue.", "The disclosed technology can, when integrated with specialized surgical instrumentation, fusing ultrasound images with other data, can give surgeons added abilities to locate and manipulate anatomic areas of interest while minimizing unnecessary damage to nearby structures.", "The disclosed technology can reduce the amount of time for the brachytherapy treatment of malignant neoplasms by, for example, precisely guiding the insertion of catheters and sealed radioactive sources into the proper location.", "Similarly, the disclosed technology can aid insertion of high dose, localized pharmaceuticals for treatments of diseases." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This patent document is a continuation of U.S. patent application Ser.", "No.", "15/236,229, filed on Aug. 12, 2016, which is a continuation of U.S. patent application Ser.", "No.", "14/604,612, filed on Jan. 23, 2015, now U.S. Pat.", "No.", "9,420,999, which is a continuation of U.S. patent application Ser.", "No.", "13/663,100, filed on Oct. 29, 2012, now U.S. Pat.", "No.", "8,939,909, which claims the benefit of priority of U.S.", "Provisional Patent Application No.", "61/553,137, filed on Oct. 28, 2011.The entire contents of the before-mentioned patent applications are incorporated by reference as part of the disclosure of this document.", "TECHNICAL FIELD This patent document relates to systems and processes for ultrasound diagnostics.", "BACKGROUND Ultrasound imaging is an imaging modality that employs the properties of sound waves traveling through a medium to render a visual image.", "Ultrasound imaging has been used as an imaging modality for decades in a variety of biomedical fields to view internal structures and functions of animals and humans.", "Ultrasound waves used in biomedical imaging may operate in different frequencies, e.g., between 1 and 20 MHz, or even higher frequencies.", "Some factors including inadequate spatial resolution and tissue differentiation can lead to less than desirable image quality using conventional techniques of ultrasound imaging, which can limit its use for many clinical applications.", "SUMMARY Techniques, systems, and apparatuses are disclosed for ultrasound diagnostics using spread spectrum, coherent, frequency- and/or phase-coded waveforms that can exhibit wide instantaneous bandwidth.", "In one aspect of the disclosed technology, a method of creating an image from an acoustic waveform in an acoustic imaging device includes setting a transmit/receive switch in the acoustic imaging device into a transmit mode to transmit an acoustic waveform toward a target, in transmitting the acoustic waveform, synthesizing, in one or more waveform synthesizers, a plurality of substantially orthogonal coded waveforms that form a composite waveform as the transmitted acoustic waveform toward the target, in which each waveform corresponds to a distinct frequency band and the coded waveforms include at least one of frequency-coded waveforms or phase-coded waveforms, setting the transmit/receive switch in the acoustic imaging device into a receive mode to receive a returned acoustic waveform that returns from at least part of the target, converting the received returned acoustic waveform from analog format to digital format as a received composite waveform comprising information of the target, and processing the received composite waveform to produce an image of at least part of the target.", "In another aspect, an acoustic waveform imaging system is provided to include waveform generation unit comprising one or more waveform synthesizers coupled to a waveform generator, wherein the waveform generation unit synthesizes a composite waveform comprising a plurality of substantially orthogonal coded waveforms corresponding to frequency bands that are generated by the one or more waveform synthesizers according to waveform information provided by the waveform generator, the coded waveforms including at least one of frequency-coded waveforms or phase-coded waveforms; a transmit/receive switching unit that switches between a transmit mode and a receive mode; an array of transducer elements in communication with the transmit/receive switching unit that transmits an acoustic waveform based on the composite waveform toward a target and receives a returned acoustic waveform returned from at least part of the target; an array of analog to digital (A/D) converters to convert the received returned acoustic waveform received by the array of transducer elements from analog format to digital format as a received composite waveform comprising information comprising information of the target; a controller unit in communication with the waveform generation unit and the array of A/D converters comprising a processing unit that processes the received composite waveform to produce an image of at least part of the target; and a user interface unit in communication with the controller unit.", "In another aspect, a method of creating an image from an acoustic waveform is provided to include setting a transmit/receive switch into transmit mode; selecting a mode of operation from a plurality of operating modes; synthesizing, in one or more waveform synthesizers, a plurality of substantially orthogonal coded waveforms that form a composite waveform, wherein each waveform corresponds to a distinct frequency band, the coded waveforms including at least one of frequency-coded waveforms or phase-coded waveforms; transmitting an acoustic waveform based on the composite waveform toward a target; setting the transmit/receive switch into receive mode; receiving a returned acoustic waveform returned from at least part of the target; converting the received returned acoustic waveform from analog format to digital format as a received composite waveform comprising information of the target; and processing the received composite waveform to produce an image of at least part of the target.", "In another aspect, a method of creating an image from an acoustic waveform is provided to include combining a plurality of coded waveforms corresponding to different frequency bands to produce a composite waveform comprising substantially orthogonal wave signals at the different frequency bands, the coded waveforms including at least one of frequency-coded waveforms or phase-coded waveforms; using the composite waveform to produce an acoustic probe wave that includes the different frequency bands toward a target; receiving acoustic energy returned from at least part of the target after the acoustic probe wave is sent to the target; converting the received returned acoustic energy into a digital composite waveform comprising information of the target; and processing the received composite waveform to produce an image of at least part of the target.", "In yet another aspect, a device for creating an image from an acoustic waveform is provided to include means for combining a plurality of coded waveforms corresponding to different frequency bands to produce a composite waveform comprising substantially orthogonal wave signals at the different frequency bands, the coded waveforms including at least one of frequency-coded waveforms or phase-coded waveforms; means for using the composite waveform to produce an acoustic probe wave that includes the different frequency bands toward a target; means for receiving acoustic energy returned from at least part of the target after the acoustic probe wave is sent to the target; means for converting the received returned acoustic energy into a digital composite waveform comprising information of the target; and means for processing the received composite waveform to produce an image of at least part of the target.", "The subject matter described in this patent document can provide one or more of the following features and be used in many applications.", "For example, the disclosed technology can be used during routine primary care screenings to identify and locate early stage malignancies, as well as later stage cancers, which can potentially raise survival rates of hard to diagnose asymptomatic patients.", "The disclosed technology can be used by board certified radiologists to diagnose neoplasms as benign or malignant prior to any surgical biopsy or resection intervention, which may also improve patient survival rate while reducing unnecessary biopsies.", "The disclosed technology can, when integrated with a fine needle biopsy instrument, be used in medical procedures to confirm noninvasive diagnoses, which can reduce the level of invasiveness of such biopsy procedures.", "The disclosed technology can, when integrated with minimally invasive surgical high definition video instrumentation, fuse optical and ultrasound images, which can further give surgeons added abilities to locate and surgically excise diseased tissue without excising excessive healthy tissue.", "The disclosed technology can, when integrated with specialized surgical instrumentation, fusing ultrasound images with other data, can give surgeons added abilities to locate and manipulate anatomic areas of interest while minimizing unnecessary damage to nearby structures.", "The disclosed technology can reduce the amount of time for the brachytherapy treatment of malignant neoplasms by, for example, precisely guiding the insertion of catheters and sealed radioactive sources into the proper location.", "Similarly, the disclosed technology can aid insertion of high dose, localized pharmaceuticals for treatments of diseases.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1A shows a block diagram of an exemplary ultrasound imaging system using spread spectrum coded waveforms.", "FIG.", "1B shows a chart for operation of an exemplary ultrasound imaging system using spread spectrum coded waveforms.", "FIG.", "2 shows a graph of an exemplary spread spectrum, wide instantaneous bandwidth, frequency- and/or phase-coded waveform featuring a plurality of waveforms.", "FIG.", "3 shows ambiguity function characteristics of an exemplary spread spectrum coded waveform.", "FIGS.", "4A-4C show an exemplary diagram for beam steering, dynamic focusing, and forming.", "FIG.", "5 shows an exemplary block diagram for correlation processing of a spread spectrum coded waveform.", "Like reference symbols and designations in the various drawings indicate like elements.", "DETAILED DESCRIPTION Techniques, systems, and apparatuses are described for generating, transmitting, receiving, and processing coherent spread spectrum frequency- and/or phase-coded waveforms used in ultrasound diagnostics.", "Ultrasound imaging can be performed by emitting a time-gated, single frequency or narrow instantaneous bandwidth acoustic waveform (pulse), which is partly reflected from a boundary between two mediums (e.g., biological tissue structures) and partially transmitted.", "The reflection can depend on the acoustic impedance difference between the two mediums.", "Ultrasound imaging by some techniques may only use amplitude information from the reflected signal.", "For example, when one pulse is emitted, the reflected signal can be sampled continuously.", "In biological tissue, sound velocity can be considered fairly constant, in which the time between the emission of a waveform and the reception of a reflected signal is dependent on the distance the waveform travels in that tissue structure (e.g., the depth of the reflecting structure).", "Therefore, reflected signals may be sampled at multiple time intervals to receive the reflected signals being reflected from multiple depths.", "Also, different tissues at the different depths can partially reflect the incident waveform with different amounts of energy, and thus the reflected signal from different mediums can have different amplitudes.", "A corresponding ultrasound image can be constructed based on depth.", "The time before a new waveform is emitted can therefore be dependent of the maximum depth that is desired to image.", "Ultrasound imaging techniques employing pulsed monochromatic and/or narrow instantaneous bandwidth waveforms can suffer from poor resolution of image processing and production.", "Yet, waveforms with spread spectrum, wide instantaneous bandwidth characteristics that can be coded (e.g., by frequency and/or phase) can enable real-time control of ultrasound imaging and higher quality resultant images.", "FIG.", "1A shows a block diagram of an exemplary ultrasound system (100) that can produce acoustic waveforms with enhanced waveform properties that include a spread-spectrum, wide instantaneous bandwidth, coherency, pseudo-random noise characteristics, and frequency- and/or phase-coding.", "System (100) can be configured in one of many system designs.", "In one example, system (100) can include a Master Clock (101) for time synchronization.", "The Master Clock (101) can be interfaced with a System Controller (102).", "System Controller (102) can include a processing unit, e.g., a central processing unit (CPU) of RISC-based or other types of CPU architectures.", "System Controller (102) can also include at least one input/output (I/O) unit(s) and/or memory unit(s), which are in communication with the processing unit, to support various functions of the System Controller (102).", "For example, the processing unit can be associated with a system control bus, e.g., Data & Control Bus (103).", "System Controller (102) can be implemented as one of various data processing architectures, such as a personal computer (PC), laptop, tablet, and mobile communication device architectures.", "The memory unit(s) can store other information and data, such as instructions, software, values, images, and other data processed or referenced by the processing unit.", "Various types of Random Access Memory (RAM) devices, Read Only Memory (ROM) devices, Flash Memory devices, and other suitable storage media can be used to implement storage functions of the memory unit(s).", "The memory unit(s) can store pre-stored waveforms and coefficient data and information, which can be used in the implementation of generating a waveform, e.g., such as a spread-spectrum, wide instantaneous bandwidth, coherent, pseudo-random noise, and frequency and/or phase-coded waveform.", "The memory unit(s) can store data and information obtained from received and processed waveforms, which can be used to generate and transmit new waveforms.", "The memory unit(s) can be associated with a system control bus, e.g., Data & Control Bus (103).", "The I/O unit(s) can be connected to an external interface, source of data storage, and/or display device.", "The I/O unit(s) can be associated with a system control bus, e.g., Data & Control Bus (103).", "Various types of wired or wireless interfaces compatible with typical data communication standards, such as but not limited to Universal Serial Bus (USB), IEEE 1394 (FireWire), Bluetooth, IEEE 802.111, Wireless Local Area Network (WLAN), Wireless Personal Area Network (WPAN), Wireless Wide Area Network (WWAN), WiMAX, IEEE 802.16 (Worldwide Interoperability for Microwave Access (WiMAX)), and parallel interfaces, can be used to implement the I/O unit.", "The I/O unit can interface with an external interface, source of data storage, or display device to retrieve and transfer data and information that can be processed by the processor unit, stored in the memory unit, or exhibited on an output unit.", "System Controller (102) can control all of the modules of system (100), e.g., through connection via Data & Control Bus (103).", "For example, Data & Control Bus (103) can link System Controller (102) to one or more attached digital signal processors, e.g., Digital Signal Processor (104), for processing waveforms for their functional control.", "Digital Signal Processor (104) can include one or many processors, such as but not limited to ASIC (application-specific integrated circuit), FPGA (field-programmable gate array), DSP (digital signal processor), AsAP (asynchronous array of simple processors), and other types of data processing architectures.", "Data & Control Bus (103) can also link System Controller (102), as well as Digital Signal Processor (104), to one or more display units with modules for user interfaces, e.g., Display (105) with a module User Interface (106) to provide information to a user or operator and to receive input/commands from the user or operator.", "Display (105) can include many suitable display units, such as but not limited to cathode ray tube (CRT), light emitting diode (LED), and liquid crystal display (LCD) monitor and/or screen as a visual display.", "Display (105) can also include various types of display, speaker, or printing interfaces.", "In other examples, Display (105) can include other output apparatuses, such as toner, liquid inkjet, solid ink, dye sublimation, inkless (such as thermal or UV) printing apparatuses and various types of audio signal transducer apparatuses.", "User Interface (106) can include many suitable interfaces including various types of keyboard, mouse, voice command, touch pad, and brain-machine interface apparatuses.", "The exemplary system (100) can include Waveform Generator (107), which can be controlled by System Controller (102) for producing one or more digital waveforms.", "The one or more digital waveforms can be generated as analog electronic signals (e.g., analog waveforms) by at least one element in an array of waveform synthesizers and beam controllers, e.g., represented in this example as Waveform Synthesizer and Beam Controller (108).", "Waveform Generator (107) can be at least one of a function generator and an arbitrary waveform generator (AWG).", "For example, Waveform Generator (107) can be configured as an AWG to generate arbitrary digital waveforms for Waveform Synthesizer and Beam Controller (108) to synthesize as individual analog waveforms and/or a composite analog waveform.", "Waveform Generator (107) can also include at least one memory unit(s) that can store pre-stored waveforms and coefficient data and information used in the generation of a digital waveform.", "The exemplary system (100) shown in FIG.", "1A includes Waveform Synthesizer and Beam Controller (108) comprising I number of array elements.", "In one example, Waveform Synthesizer and Beam Controller (108) can be configured to include at least one waveform synthesizer element on each line of the I number of array waveform synthesizers.", "In another example, Waveform Synthesizer and Beam Controller (108) can include at least one beam controller element on each line of the I number of array beam controllers.", "In another example, Waveform Synthesizer and Beam Controller (108) can include at least one waveform synthesizer element and beam controller element on each line of the I number of array waveform synthesizers and beam controllers.", "Waveform Synthesizer and Beam Controller (108) can include a phase-lock loop system for generation of an electronic signal, e.g., a radio frequency (RF) waveform.", "An exemplary RF waveform can be synthesized by Waveform Synthesizer and Beam Controller (108) from individual waveforms generated in the array elements of Waveform Synthesizer and Beam Controller (108), e.g., one individual RF waveform can be generated in one array element substantially simultaneously to all other individual waveforms generated by the other array elements of Waveform Synthesizer and Beam Controller (108).", "Each individual RF waveform can be defined for a particular frequency band, also referred to as a frequency component or ‘chip’, and the waveform properties of each individual waveform can be determined by Waveform Generator (107), which can include at least one amplitude value and at least one phase value corresponding to the chip.", "Waveform Generator (107) can issue commands and send waveform data including information about each individual waveform's properties to Waveform Synthesizer and Beam Controller (108) for generation of individual RF waveforms that can be composited into a composite RF waveform.", "The individual RF waveforms and/or the composite RF waveform generated by Waveform Synthesizer and Beam Controller (108) can be modified by Output Amplifiers (109), which includes an array of I number of amplifiers, e.g., by amplifying the gain and/or shifting the phase of a waveform.", "Output Amplifiers (109) can be used as transducer drivers.", "The individual RF waveforms and/or the composite RF waveform can be passed to Transmit/Receive (T/R) switch (110), e.g., an N-pole double-throw transmit/receive switch.", "T/R Switch (110) that can be interfaced with a transducer module.", "A generated RF waveform, e.g., the composite RF waveform and/or at least one individual RF waveform, that is to be transmitted into a target medium can be transduced into, for example, an acoustic wave by the transducer module that can include an array of transducer elements, e.g., Transducer Array (111) comprising I number of elements.", "For example, the transduced acoustic wave can be emitted in the form of an acoustic waveform pulse.", "Each array element of the Transducer Array (111) may generate one or more acoustic waveforms that correspond to the individual waveform chips determined by the Waveform Generator (107).", "The exemplary transduced transmitted acoustic waveform can be transmitted toward a target area, e.g., biological tissue, and form a spatially combined acoustic waveform.", "The transmitted waveform can propagate into the target medium, which for example, can have one or more inhomogeneous mediums that partially transmit and partially reflect the transmitted acoustic waveform.", "Exemplary acoustic waveforms that are partially reflected, also referred to as returned acoustic waveforms, can be received by Transducer Array (111).", "For example, each array element of I array elements of Transducer Array (111) can be configured to receive a returned acoustic waveform corresponding to the frequency chip and convert it to an analog RF waveform.", "The individual received (analog) RF waveforms can be modified by Pre-Amplifier module (112), which includes an array of I number of amplifiers, e.g., by amplifying the gain and/or shifting the phase of a waveform.", "The individual received waveforms can be converted from analog format to digital format by analog to digital (A/D) Converter module (113), which includes an array of I number of A/D converters.", "A/D Converter module (113) can include A/D converters that have low least significant bit (LSB) jitter, spurious-free dynamic range (SFDR) and waveform dependency, such that the exemplary waveforms can be adequately decoded.", "The converted digital representations of the individual received waveforms can be processed by a processor, e.g., Digital Signal Processor (104), in manner that creates and forms a representative image of the target medium.", "The exemplary system (100) can be operated in one of many operation modes.", "In one example, Master Clock (101) can provide the time base for synchronizing the system (100), e.g., as a time base for the Waveform Synthesizers (108).", "Master Clock (101) can be configured as a low phase noise clock such that the exemplary waveforms can be phase encoded.", "An operator can select the mode of operation at User Interface (106).", "Exemplary modes of operation provided for the user to select at the User Interface (106) include Conventional A-Mode (e.g., 1D Depth only image), Conventional B-Mode (e.g., 2D Plane image—transverse vs. depth), Conventional C-Mode (e.g., 2D Plane image at selected depth), and Conventional D-Modes (e.g., Doppler Modes).", "Exemplary Doppler modes include Color Doppler (e.g.", "superposition of color coded Doppler and B-mode images), Continuous Doppler (e.g., 1D Doppler profile vs. depth), Pulsed Wave Doppler (e.g., Doppler vs. time for selected volume), and Duplex/Triplex Doppler (e.g., superposition of Conventional B-Mode, Conventional C-Mode or Color Doppler, and Pulsed Wave Doppler).", "Some other exemplary modes of operations can include Conventional 3D and 4D (“real time” 3D) volume renderings of the previously described modes of operations.", "The exemplary system (100) can implement new modes of operation that can generate spread spectrum, wide instantaneous bandwidth, frequency- and/or phase-coded waveforms.", "For example, a user can select exemplary ATS-Modes (Artificial Tissue Staining Modes) that can comprise a B-Mode, a C-Mode, a D-Mode, or other mode combined with image color coding to aid tissue differentiation—analogous to tissue staining for microscopic histological studies; and exemplary CAD-Modes (Computer Aided Diagnostic Modes) that differentiate and identify tissue type.", "ATS-Modes can employ the use of features for image color coding in image processing based on one or more of a number of measured properties that are obtained from the returned echo waveform from the target area, e.g., the returned echo from an exemplary transmitted spread spectrum, wide instantaneous bandwidth, coded acoustic waveform.", "CAD-Modes can use classifiers (algorithms) to classify, for example, tissue types based on features of the measured properties of the returned echo from the target area, e.g., the returned echo from an exemplary spread spectrum, wide instantaneous bandwidth, coded acoustic waveforms.", "The features properties can include differing impedances, amplitude reflections (as a function of wavelength), group delay, etc.", "Some exemplary classifiers that can be employed using CAD-Modes can include deterministic classifiers, stochastic classifiers (e.g., Bayesian classifiers), and neural network classifiers.", "FIG.", "1B shows an exemplary operation process (150) for operating the system (100) for ultrasound imaging.", "For each time epoch, process (150) can begin by implementing process (151) to switch system (100) in transmit mode.", "For example, the System Controller (102) can command an N-pole double-throw T/R switch, e.g., T/R Switch (110), to transmit position.", "Process (150) includes a process (152) to check a user-defined mode of operation.", "For example, mode of operation can be selected by a user using User Interface (106), or the mode of operation can be selected by another entity or internally within system (100).", "Based on the selected operation mode, System Controller (102) can command Waveform Generator (107) to issue a digital message (data) to one or more elements in Waveform Synthesizers and Beam Controllers (108) that defines the frequency, amplitude and phase of each of the frequency chips that form a desired wideband composite RF waveform commanded, e.g., implemented in a process (153).", "Process (152) can occur anywhere and implemented in multiple instances during process (150).", "Process (150) includes a process (153) to issue waveform data (e.g., the exemplary digital message/data) to waveform synthesizers and beam formers, such as the Waveform Synthesizers and Beam Controllers (108).", "The issued waveform data can include the frequency, amplitude and phase information of the desired frequency chips that are synthesized as frequency- and/or phase-coded waveforms, in which each coded waveform corresponds to a distinct frequency band.", "Process (150) includes a process (154) to generate individual analog RF waveforms that correspond to defined frequency chips.", "For example, each element in the array of Waveform Synthesizers and Beam Controllers (108) can convert the digital message/data from the Waveform Generator (107) into individual analog waveforms that can make up a coherent analog wideband composite waveform.", "Process (150) includes a process (155) to amplify the individual analog waveforms that can make up a coherent analog wideband composite waveform.", "For example, each analog waveform and/or wideband composite waveform can be amplified by an array element in Output Amplifier (109).", "The amplified analog wideband composite waveform can then pass through the T/R Switch (110) and excite its respective array element of the Transducer Array (111) (e.g., in an ultrasound probe).", "Process (150) includes a process (156) to transduce the composite analog waveform to an acoustic waveform that can propagate throughout the scanned volume.", "For example, each element of the Transducer Array (111) can provide an acoustic waveform from each of the individual analog waveform corresponding to the frequency chip generated in Waveform Synthesizer and Beam Controller (108) that makes up the wideband composite acoustic waveform.", "Transducer Array (111) can form the acoustic beam that propagates into the target medium, e.g., biological tissue volume under study.", "At the end of process (156), process (150) can implement process (157) to switch system (100) in receive mode.", "For example, the System Controller (102) can command the N-pole double-throw T/R Switch (110) to receive position.", "Process (150) includes a process (158) to receive a returned acoustic waveform, which can be in the form of one or more returned acoustic waveforms (also referred to as acoustic waveform echoes).", "Process (158) can also include transducing the returned acoustic waveform echo(es) into individual received analog waveforms, e.g., corresponding to the frequency chips of the generated individual waveforms.", "For example, the returned acoustic waveform propagates back to and is received by Transducer Array (111).", "Each element of Transducer Array (111) can convert the received acoustic waveform it receives into an analog signal (waveform).", "Process (150) includes a process (159) to amplify the individual received analog waveforms.", "For example, each received analog waveform can be amplified by its respective low noise pre-amplifier element in Pre-Amplifier module (112).", "Process (150) includes a process (160) to convert the individual received analog waveforms into digital waveform data.", "For example, each received (and amplified) analog waveform signal can be converted into a digital word by each respective A/D element in A/D Converter module (113).", "The digital format data can be sent to Digital Signal Processor (104) for signal processing.", "Process (150) includes a process (161) to process the digital waveform data into image frames representative of the target medium.", "Process (161) can also include compositing the digital waveform data into a composite digital signal representing the individual and composite received analog waveform.", "For example, Digital Signal Processor (104) can detect the amplitude and phase of each of the frequency chips that comprise the wideband composite acoustic waveform received by each of the transducer array elements.", "Digital Signal Processor (104) can form the received beam and separate the amplitude and Doppler components of each resolution element of the beam, and can form an image frame associated with mode previously selected by operator.", "The image frame formed by Digital Signal Processor (104) can be displayed on Display (105) to the user.", "For other subsequent time epochs, System Controller (102) can repeat this exemplary process, e.g., by commanding Waveform Generator (107) to issue to each element in Waveform Synthesizers (108) another digital message that defines the amplitude and phase of each of the frequency chips that comprise the wideband composite waveform and by commanding T/R Switch (110) back to transmit position, etc.", "The system (100) can be implemented to produce spread-spectrum, wide instantaneous bandwidth (e.g., up to 100% or more of fractional bandwidth), coherent, pseudo-random noise (PRN), frequency- and/or phase-coded waveforms for ultrasound imaging.", "There are limitless embodiments of such waveforms.", "One example is featured in FIG.", "2, which shows an exemplary plot of a generated composite waveform (200) that is comprised of a plurality of individual waveforms (e.g., frequency chips).", "In some implementations, the individual waveforms of the composite waveform (200) can be PRN waveforms including a sequence of pulses for each frequency chip that repeats itself after a sequence or code period (T), e.g., such that the sequence has a very low correlation with any other sequence in the set of frequency chips, or with the same sequence at a significantly different time frame, or with narrow band interference or thermal noise.", "For example, the system (100) can generate exactly the same sequences of the exemplary PRN waveforms at both the transmitter and the receiver ends, so a received signal sequence (based on the transmitted signal sequence) can exhibit a high correlation for signal processing to produce an acoustic image of the target.", "As shown in FIG.", "2, an exemplary individual waveform or chip (201) of the composite waveform (200) corresponds to the frequency chip fN−2 that is transmitted during a transmit period T beginning at time frame to, e.g., as described in the process (156) in FIG.", "1B.", "As shown in FIG.", "2, following the transmit period T, a receive time interval TR is exhibited, in which returned acoustic waveform echoes are received as described in the process (158) in FIG.", "1B.", "The transmit period T and the receive time interval TR form a frame period Tf, which can be repeated in subsequent time frames (t1, t2, t3, .", ".", ".", ").", "The exemplary composite waveform (200) can be represented by an equation for waveform, W, which can be represented in the time domain as a complex number, given by Equation (1): W  ( t ) = ∑ k  ∑ n  A n  e j  ( 2  π   n   f 0  t + Φ nk + C n )  U  ( t - kT f ) ( 1 ) W is comprised of M individual orthogonal waveforms (e.g., orthogonal frequency chips), where j=−√{square root over (−1)}.", "In Equation (1), T represents the chip duration or period of the coded sequence, and f0 represents the fundamental chip frequency, such that f0=1/NT, and in which Nf0 is the maximum frequency and (M−N+1)f0 is the minimum frequency.", "n represents a sequence of positive integers from N−M+1 to N. The waveform repetition frequency is 1/Tf, with Tf being the duration of a frame or epoch, and U(x)=1 for 0≤x≤Tf.", "Φnk represents the frequency chip phase term of the nth chip in the kth time epoch, and An is the amplitude of the nth chip.", "The frequency chip phase term Φnk can be a pseudo-random phase term, in which a pseudo-randomly scrambled starting phase Φnk is a random number in the set {Ink2π/N}, where Ink is a sequence of random, positive integers selected without replacement from the series I=0, 1, 2, 3, .", ".", ".", ", N, with N being a large number.", "Cn, which is an additive phase term, is a number between 0 and 2π.", "For example, the frequency chip phase pseudo-random values Φnk can be pre-stored in an exemplary database within a memory unit of System Controller (102) and/or Waveform Generator (107).", "The composite waveform, W, can be formed by synthesizing substantially orthogonal coded waveforms (e.g., frequency chips), in which each coded waveform corresponds to a distinct frequency band, and the coded waveforms includes at least one of frequency-coded waveforms or phase-coded waveforms, e.g., the coded waveforms synthesized in the Waveform Synthesizers (108).", "The coded waveforms can be synthesized as frequency-coded waveforms by selecting two or more frequencies that define the carrier frequencies of the frequency chips (e.g., including selecting the minimum and maximum frequency) and determining the An amplitude values of the frequency chips.", "The synthesis of the frequency-coded can also include determining a time-bandwidth product (Mf0T) parameter of each waveform of the coded waveforms.", "In some implementations, the amplitude for a particular frequency chip can be determined as a single value for that frequency chip during a particular time epoch and repeated in subsequent time epochs for the particular frequency chip.", "In other implementations, the amplitude for a particular frequency chip can be determined as a single value for that frequency chip during a particular time epoch and assigned a different single value in subsequent time epochs for the particular frequency chip.", "And in other implementations, the amplitude for a particular frequency chip can be determined to include multiple amplitude values for that frequency chip during a particular time epoch, in which the multiple values of the An can be repeated or varied in subsequent time epochs for the particular frequency chip.", "The selection of the range of frequencies from the maximum frequency (Nf0) to the minimum frequency ((M-N+1)f0) plus the set of individual waveform amplitude terms (An) can utilize one of many known code sequences (e.g.", "including pushing sequences, Barker Codes, etc.)", "or, for example, utilize a numerical search on pseudo-random codes or any other codes for minimum ambiguity sidelobes.", "The coded waveforms can additionally or alternatively be synthesized as phase-coded waveforms by determining individual waveform phase terms (Φnk) of each waveform of the coded waveforms.", "For example, to provide variation of the composite waveform, W, the phase Φnk can include one or more phase values for a frequency chip within the transmit period T. In some implementations, the phase Φnk for a particular frequency chip can be determined as a single value for that frequency chip during a particular time epoch and repeated in subsequent time epochs for the particular frequency chip.", "In other implementations, the phase Φnk for a particular frequency chip can be determined as a single value for that frequency chip during a particular time epoch and assigned a different single value in subsequent time epochs for the particular frequency chip.", "And in other implementations, the phase Φnk for a particular frequency chip can be determined to include multiple values for that frequency chip during a particular time epoch, in which the multiple values of the Φnk can be repeated or varied in subsequent time epochs for the particular frequency chip.", "For example, the waveform (201) in the first time epoch (t0) can include a first phase ΦA, for example, as its phase shift for the beginning portion of the transmit period T and a second phase ΦB, for example, as its phase shift for the latter portion of the transmit period T. The waveform (201) in the next time epoch (t1) can repeat the exemplary phases ΦA and ΦB as its beginning and latter phase shifts or include another phase shift sequence (e.g., such as ΦA, ΦB, ΦC, or such as ΦB and ΦA, or other configurations).", "The synthesis of the frequency-coded can also include determining a time-bandwidth product (Mf0T) parameter of each waveform of the coded waveforms.", "An exemplary transmitted waveform, W, can be comprised of the set of M individual waveforms that are orthogonal and completely span the frequency range fN−M+1 to fN, as seen in FIG.", "2.The parameter N can be chosen to be a large number to give W a wide instantaneous bandwidth.", "In the special case when the lowest frequency fN−M+1=1/T, then W can describe any wideband waveform that may be contained within this range of frequencies.", "For any waveform among the M individual waveforms, one or more phases (e.g., Φnk) can be encoded in a single waveform during the interval T. Additionally, any waveform among the M individual waveforms can include multiple amplitudes encoded in a single waveform.", "This can be implemented by amplitude weighting and phase weighting.", "The family of individual waveforms described by Equation (1) can form a coherent, pseudo-random noise, frequency- and/or phase-coded, spread spectrum composite waveform.", "Based on the selection of parameters, the individual waveforms can be made to be statistically orthogonal to any degree desired.", "For example, the sidelobe levels of the ambiguity function, described later in Equation (2), for a given waveform represents the degree of orthogonality of that waveform.", "By determining particular parameters of the waveforms, medical ultrasound image resolution can be significantly improved.", "For example, parameters that affect the resolution of medical ultrasound images include the time-bandwidth product (Mf0T) parameter, which determines the inherent combined axial range (e.g., Doppler resolution) and the speckle reduction ability of the waveform, and the individual waveform phase terms (Φnk), which determine the statistical degree of orthogonality, e.g., which in turn determines the degree that the waveform can function in inhomogeneous media of biological tissues.", "For example, the lower the sidelobes, the greater the orthogonality and greater the resolution (less noise).", "The selection of the set of individual waveform phase terms (Φnk) can utilize one of many known code sequences (e.g.", "including Barker, Frank, Golay, etc.)", "or, for example, utilize a numerical search on pseudo-random codes or any other codes for minimum ambiguity sidelobes.", "In some implementations, the composite waveform (200), e.g., described by Equation (1), can be a single wideband, coherent, frequency- and/or phase-coded waveform.", "For example, based on the selection of parameters, the single waveform can be made to be statistically orthogonal to any other signal waveform or noise signal present in the target medium.", "The parameter An, which is the amplitude of the nth chip, and Cn, which is an additive phase term, in combination can provide pre-emphasis of the analog signal that excites each individual element of Transducer Array (111) to produce a transmitted acoustic waveform that has the desired amplitude and phase characteristics over the frequency range of W. Pre-emphasis of the transmitted waveform can compensate for both the non-constant amplitude and phase response of transducer elements as a function of frequency, and the non-uniform propagation characteristics of intervening tissue layers.", "For example, the pre-emphasis terms can provide an acoustic waveform that has equal amplitude chips with constant (e.g., flat) amplitude and a known phase versus frequency characteristic.", "Such constant amplitude versus frequency acoustic waveforms can be referred to as ‘white’ waveforms.", "Alternatively, if pre-emphasis is not provided, then the transmitted acoustic waveform can replicate the frequency response of the transducer, and such waveforms are referred to as ‘colored’ waveforms.", "De-emphasis of the received waveform can permit determination of the reflection characteristic of the target medium's volume, e.g., biological tissue volume.", "By inspection, single frequency modes (e.g., Conventional A-, B- and C-Mode), due to their monochromatic nature, do not need pre-emphasis.", "Such single frequency waveforms may require amplitude control, for example, to ensure biologically safe sound intensity limits.", "If the phase of each chip is random, the transmitted waveform, W, can have random noise-like characteristics.", "If the phases (Φnk+Cn) of each chip are uniquely determined, repeatable and synchronized to the Master Clock (as shown in FIG.", "1A), the transmitted waveform, W, can be classified as pseudo-random noise.", "Such pseudo-random noise waveforms are coherent permitting implementation of coherent receivers.", "Image processing advantages of wide instantaneous bandwidth, pseudo-random noise waveforms can include reduction, with proper waveform selection, and potential elimination of speckle, e.g., speckles/speckle patterns, which are random intensity patterns produced by the mutual interference waveforms, which are commonly associated with conventional medical ultrasound images.", "This exemplary reduction in speckle can be an analogous comparison of a scene illuminated by wide band, Gaussian noise-like white light, which has no observable speckle to narrow band laser illumination with exhibits strong speckle of the same scene.", "Signal processing advantages of coherent, pseudo-random noise, frequency- and phase-coded waveforms can include waveforms having very low time and Doppler sidelobes.", "For example, an ambiguity function, A(τ,υ), can be a two-dimensional representation that shows the distortion of a received waveform processed by a matched filter in the receiver due to the effect of Doppler shift (υ) or propagation delay (τ).", "Specifically, the exemplary ambiguity function A(τ,υ) is defined by Equation (2) and is determined solely by the waveform properties and the receiver characteristics and not by the scenario.", "The ambiguity function of A(τ,υ) is defined by A  ( τ , υ ) = ∫ - ∞ + ∞  X a  ( t )  X b *  ( t - τ )  e j   2  π   υ   t    where   X k  ( t ) = 1 T  e j  [ 2   π   f k  ( t - t k ) + Φ k ] ,  for   0 ≤ t ≤ T , X k  ( t ) = 0   otherwise .", "( 2 ) For waveforms of the type described by Equation (1), the following equation can be obtained: A  ( τ , υ , t , f n , Φ n , f m , Φ m , T ) = ( 1 -  τ - ( Δ   t )  T )  Sin  [ 2  π  ( Δ   f )  ( T -  Δ   t  ) ] [ 2  π  ( Δ   f )  ( T -  Δ   t  ) ]  e j   2   π  [ Δ   f  ( T + Δ   t ) - f n  Δ   t + υ   t + ΔΦ ] ( 3 ) where Δt=τ−t, Δf=υ−(fn−fm), and ΔΦ=Φn−Φm, which can result in the complete ambiguity equation shown in Equation (4): x  ( τ , υ ) = 1 M  ∑ n  ∑ m  A  ( τ , υ , t , f n , Φ n , f m , Φ m , T ) ( 4 ) where both n and m are a sequence of positive integers from N−M+1 to N. FIG.", "3 shows exemplary ambiguity function characteristics of a pseudo-random noise, frequency-coded waveform (301), represented by an equation for waveform, W. The exemplary coded waveform (301) includes a code length of 128.As shown in FIG.", "3, the sidelobes (302) of this ambiguity function are due to chip-to-chip phase interactions and have a plateau level below the peak that is a function of N2.By inspection, many waveforms (W) are possible depending on the specific random number codes (Ink) selected.", "However, the sidelobe performance cannot be guaranteed for every waveform defined, and therefore only those codes which give sufficiently low sidelobes as determined by a numerical search of a set of possible codes should be used.", "For example, in medical ultrasound applications, living tissue as a propagation medium is inhomogeneous.", "Propagation medium inhomogeneity can introduce differential time delays, and living tissue can introduce unwanted motion induced Doppler.", "Ultrasound transducer arrays also can have undesirable side lobes and grating lobes (e.g., due to physical size limitations) in the off axis portions of ultrasound beam that add unwanted time delay and Doppler returns to the returns of the main lobe.", "Waveforms that exhibit low ambiguity function sidelobes can significantly improve focusing and target contrast due through the reduction interference from differential time delays, motion induced Doppler, transducer side lobe effects.", "Coherent pseudo-random noise, frequency- and/or phase-coded waveforms can enable higher order cross range focusing techniques to be employed that can improve the lateral resolution of size limited ultrasound transducer arrays, e.g., medical ultrasound transducer arrays.", "For example, each biological tissue type and each diseased tissue types may exhibit their own unique ultrasound echo return as a function of frequency and spatial morphology.", "Using conventional Elastograph-Mode (E-Mode) modalities, it can be difficult to take advantage of such properties to classify tissues, e.g., due to measurement errors such as the inability to accurately characterize the ultrasound wave propagation through overlaying inhomogeneous media.", "Exemplary waveforms produced by the exemplary system (100), e.g., wide instantaneous bandwidth, coherent pseudo-random noise, frequency- and/or phase-coded waveforms, can enable tissue differentiation by simultaneously determining the propagation delay for each acoustic ray through intervening tissue layers and accurately determining the spatial echo features of the target volume under investigation.", "Classifiers, one example being Bayesian inference Classifiers among others, can be applied to the feature data obtained from the measured characteristics of the received echo to automatically classify tissue types observed in the target volume providing a Computer Aided Diagnostic-Mode (CAD-Mode).", "Unlike conventional E-Modes, which inherently have significantly reduced image quality and rely on individual operator technique, the exemplary waveforms described by Equation (1) can inherently provide improved image quality while simultaneously colorizing the resultant image by tissue type in the ATS and/or CAD-Modes.", "With this advantage, user technique can be mitigated and the margins of a lesion are discernible thus permitting improved diagnoses.", "In addition, Waveform Synthesizers (108) positioned on transmit and Digital Signal Processor (104) positioned on receive (as shown in FIG.", "1A), can also perform beam control (e.g., beam steering, dynamic beam focusing, and beam forming) functions.", "FIGS.", "4A-4C show the basics of these digital electronic functions by introducing a differential time delay, or equivalently a phase shift, and amplitude weighting between each of the elements of the phased array.", "As can be seen in FIG.", "4A, the differential phase shift can compensate for the differential change in distance (d) each acoustic ray (r1, r2, .", ".", ".", "ri, .", ".", ". )", "travels from ith element to the point of focus (p).", "An angle (θ) is formed as the point of focus (p) is not along the z-axis direction of direct aim/alignment of the Transducer Array (111) toward a target in the target medium.", "Additionally, a differential amplitude weight can be applied to each element to control the beam shape and suppress side and grating lobes.", "Also, for one or more chips in an exemplary waveform, Waveform Generator (107) can pre-encode a phase delay to delay the phase of the one or more chips transmitted at each transducer element in Transducer Array (111).", "An exemplary result of this feature can be seen in FIGS.", "4B and 4C.", "The exemplary phase delay values for the one or more chips can be communicated to Digital Signal Processor (104) and/or System Controller (102) to incorporate the phase delay values in the signal processing of the received composite waveform.", "For narrow instantaneous bandwidth ultrasound devices, this function can be accomplished by introducing phase shift and amplitude attenuation on the composite analog signal driving each element.", "However, for the exemplary spread-spectrum, wide instantaneous bandwidth, frequency- and phase-coded waveforms generated by system (100), each individual chip of the waveform (Wi) is individually amplitude weighted (Bni) and phase weighted (Dni) as a function of frequency (n) for each array element (i) individually for all I elements, as indicated by Equation (5).", "W i  ( t ) = ∑ k  ∑ n  A n  B ni  e j   ( 2  π   nf 0  t + Φ nk + C n + D ni )  U  ( t - kT f ) ( 5 ) On transmit, the amplitude and phase weighting required of each chip can be computed by the System Controller (102) and can be sent as an instruction to the Waveform Generator (107).", "Waveform Generator (107) can then send the digital words (real and imaginary components) to the Waveform Synthesizers and Beam Controller (108) that produces the analog drive signal that is amplified by Amplifier (109) and sent to each element of the array of Transducer Array (111).", "On receive, the reverse process takes place.", "The A/D Converter module (113) can send the digital words that represent the amplitude and phase information of each chip for each array element to the Digital Signal Processor (104), which in turn can digitally form the receive beam for each chip.", "A multitude of ways can be used to process the received waveforms, e.g., wide-bandwidth, spread-spectrum, frequency and/or phase-coded waveforms.", "FIG.", "5 shows an exemplary correlation processing technique.", "For example, an input to the exemplary correlation processing technique can include a digitized received signal, Yi(τ,υ), which can be multiplied by the complex conjugate replica of the transmitted digital waveform, Wi*(τ).", "The complex conjugate replica Wi*(τ) can be time shifted by 1·τ0 to prior to multiplication.", "This multiplication operation can be repeated multiple times for multiple time shifts, e.g., J times, as seen in FIG.", "5.The multiple multiplication operations for the multiple time shifts can be repeated in parallel, but for each operation the replica is shifted in time by an increment, τ0, from the previous one, as shown in the figure.", "For each time step, the resultant products can be filtered with a window function, such as a Hann, Hamming, Tukey, Kaiser Bessel, Dolph-Chebyshev, Blackman-Harris window, etc., a fast Fourier Transform (FFT) integrator, and passed through a digital filter.", "For example, a digital filter of a type that is dependent of the specific waveform, W, can be employed to filter and decimate the inputted signal.", "The exemplary process can result in the range-Doppler return for each individual ith element of the transducer array.", "The output data stream from the exemplary detection algorithm can then be processed using conventional techniques to form an image for display.", "The processed range and Doppler data and/or waveforms can be further processed by partitioning the I number of transducer elements into two or more subarrays.", "The processed range-Doppler return for the ith element can be weighted in amplitude and/or phase depending on which subarray that ith element belongs.", "These weighted returns can then be summed and differenced.", "These sum and differences can then be processed to improve the cross range image resolution of the system.", "Several applications and uses of the disclosed technology can be implemented to exploit the described features of the aforementioned systems, methods, and devices.", "Some examples are described for clinical use of the disclosed technology.", "In one exemplary application, the resultant image quality, the ATS and CAD modes of an exemplary spread spectrum ultrasound device can enable the primary care physician to incorporate this modality into a routine examination screening protocol to locate early stage malignancies (e.g., Stage 0 or 1), as well as later stage cancers.", "As the result of this application, the device can potentially, for example, enhance the survival rate of hard to diagnose asymptomatic patients suffering from such malignancies such as stomach, pancreatic, bladder cancers, etc.", "In another exemplary application, the resultant image quality, ATS and CAD modes of an exemplary spread spectrum ultrasound device can permit board certified radiologists to diagnose neoplasms as benign or malignant prior to any surgical biopsy or resection intervention.", "As a result of this application, the ability of radiologists to locate and diagnose early stage malignancies (e.g., Stage 0 or 1) can potentially improve patient survival rate.", "Additionally, unnecessary biopsies can potentially be avoided, along with their attendant risk of hard to treat or even lethal complications such as, for example, methicillin resistant staphylococcus aureus (MRSA staph) infections.", "In another exemplary application, the resultant 3D image quality of an exemplary spread spectrum ultrasound device and its 4D imaging capability can be used in fine needle biopsy and other medical procedures.", "For example, the exemplary spread spectrum ultrasound device can be integrated into an exemplary fine needle biopsy instrument (e.g., with the device's transducer probe), which can permit the fine needle biopsy of very small, early stage (e.g., Stage 0 or 1) neoplasms to confirm noninvasive diagnoses.", "As a result of this application, the ability of surgeons to avoid open biopsies and the potential for hard to treat and lethal complications that may result is clearly beneficial to the patient.", "In another exemplary application, the integration of this device's spread spectrum transducer probe with minimally invasive surgical high definition video instrumentation can permit the fusing of the optical and ultrasound images.", "Given the improved 3D image quality of this spread spectrum ultrasound device, its 4D imaging capability, the ATS and CAD modes, such fused video and ultrasound images can give surgeons the added ability to locate and surgically excise diseased tissue without excising excessive healthy tissue.", "In another exemplary application, given the improved 3D image quality of this spread spectrum ultrasound device, its 4D imaging capability, and its ATS modes, an exemplary spread spectrum ultrasound device can reduce the amount of time for the brachytherapy treatment of malignant neoplasms by precisely guiding the insertion of catheters and sealed radioactive sources into the proper location.", "The application of this spread spectrum ultrasound device to brachytherapy can be especially useful for the treatment of small, hard to locate neoplasms and their margins.", "In another exemplary application, given the improved 3D image quality of this spread spectrum ultrasound device, its 4D imaging capability, and its ATS modes, an exemplary spread spectrum ultrasound device can enable the effective insertion of high dose, localized pharmaceutical treatments of diseases by precisely guiding the insertion of catheters and pharmaceuticals into the proper location.", "The application of this spread spectrum ultrasound device to brachytherapy can be especially useful for the treatment of small, hard to locate neoplasms.", "Implementations of the subject matter and the functional operations described in this specification, such as various modules, can be implemented in digital electronic circuitry, or in computer software, firmware, or hardware, including the structures disclosed in this specification and their structural equivalents, or in combinations of one or more of them.", "Implementations of the subject matter described in this specification can be implemented as one or more computer program products, e.g., one or more modules of computer program instructions encoded on a tangible and non-transitory computer readable medium for execution by, or to control the operation of, data processing apparatus.", "The computer readable medium can be a machine-readable storage device, a machine-readable storage substrate, a memory device, a composition of matter affecting a machine-readable propagated signal, or a combination of one or more of them.", "The term “data processing apparatus” encompasses all apparatus, devices, and machines for processing data, including by way of example a programmable processor, a computer, or multiple processors or computers.", "The apparatus can include, in addition to hardware, code that creates an execution environment for the computer program in question, e.g., code that constitutes processor firmware, a protocol stack, a database management system, an operating system, or a combination of one or more of them.", "A computer program (also known as a program, software, software application, script, or code) can be written in any form of programming language, including compiled or interpreted languages, and it can be deployed in any form, including as a stand alone program or as a module, component, subroutine, or other unit suitable for use in a computing environment.", "A computer program does not necessarily correspond to a file in a file system.", "A program can be stored in a portion of a file that holds other programs or data (e.g., one or more scripts stored in a markup language document), in a single file dedicated to the program in question, or in multiple coordinated files (e.g., files that store one or more modules, sub programs, or portions of code).", "A computer program can be deployed to be executed on one computer or on multiple computers that are located at one site or distributed across multiple sites and interconnected by a communication network.", "The processes and logic flows described in this specification can be performed by one or more programmable processors executing one or more computer programs to perform functions by operating on input data and generating output.", "The processes and logic flows can also be performed by, and apparatus can also be implemented as, special purpose logic circuitry, e.g., an FPGA (field programmable gate array) or an ASIC (application specific integrated circuit).", "Processors suitable for the execution of a computer program include, by way of example, both general and special purpose microprocessors, such as, for example, digital signal processors (DSP), and any one or more processors of any kind of digital computer.", "Generally, a processor will receive instructions and data from a read only memory or a random access memory or both.", "The essential elements of a computer are a processor for performing instructions and one or more memory devices for storing instructions and data.", "Generally, a computer will also include, or be operatively coupled to receive data from or transfer data to, or both, one or more mass storage devices for storing data, e.g., magnetic, magneto optical disks, or optical disks.", "However, a computer need not have such devices.", "Computer readable media suitable for storing computer program instructions and data include all forms of non volatile memory, media and memory devices, including by way of example semiconductor memory devices, e.g., EPROM, EEPROM, and flash memory devices.", "The processor and the memory can be supplemented by, or incorporated in, special purpose logic circuitry.", "While this patent document contains many specifics, these should not be construed as limitations on the scope of any invention or of what may be claimed, but rather as descriptions of features that may be specific to particular embodiments of particular inventions.", "Certain features that are described in this patent document in the context of separate embodiments can also be implemented in combination in a single embodiment.", "Conversely, various features that are described in the context of a single embodiment can also be implemented in multiple embodiments separately or in any suitable subcombination.", "Moreover, although features may be described above as acting in certain combinations and even initially claimed as such, one or more features from a claimed combination can in some cases be excised from the combination, and the claimed combination may be directed to a subcombination or variation of a subcombination.", "Similarly, while operations are depicted in the drawings in a particular order, this should not be understood as requiring that such operations be performed in the particular order shown or in sequential order, or that all illustrated operations be performed, to achieve desirable results.", "In certain circumstances, multitasking and parallel processing may be advantageous.", "Moreover, the separation of various system components in the embodiments described above should not be understood as requiring such separation in all embodiments.", "Only a few implementations and examples are described and other implementations, enhancements and variations can be made based on what is described and illustrated in this patent document." ] ]
Patent_15876081
[ [ "Electronic Gaming Die", "An electronic gaming die includes an enclosure, a flexible substrate, a number of light emitting diodes, a sensor, a processor and a battery.", "The enclosure has N sides where N is equal to or greater than 4.", "The flexible substrate folds into N sides and fits into an interior of the enclosure, wherein each side has an inner face, an outer face and is assigned an integer from 1 to N. The light emitting diodes are disposed on the outer face of each side of the flexible substrate, wherein the number of light emitting diodes equals the integer assigned to the side of the flexible substrate.", "The sensor, processor and battery are disposed on one of the inner faces of the flexible substrate." ], [ "1.An electronic gaming die comprising: an enclosure having N sides where N is equal to or greater than 4; a flexible substrate that folds into N sides and fits into an interior of the enclosure, wherein each side has an inner face, an outer face and is assigned an integer from 1 to N; a number of light emitting diodes disposed on the outer face of each side of the flexible substrate, wherein the number of light emitting diodes equals the integer assigned to the side of the flexible substrate; a sensor disposed on one of the inner faces of the flexible substrate; a processor disposed on one of the inner faces of the flexible substrate and communicably coupled to the sensor and the one or more light emitting diodes; and a battery disposed on one of the inner faces of the flexible substrate and electrically connected to the one or more light emitting diodes, the sensor and the processor.", "2.The electronic gaming die as recited in claim 1, wherein the sensor, the processor and the battery are disposed on an outer face of one or more additional sides of the flexible substrate that fold inside the N sides.", "3.The electronic gaming die as recited in claim 1, further comprising an insert disposed within an interior of the folded flexible substrate and sized to maintain a position of the flexible substrate against the interior of the enclosure.", "4.The electronic gaming die as recited in claim 3, wherein the insert is rigid, semi-rigid, hollow.", "5.The electronic gaming die as recited in claim 1, further comprising an adhesive or one or more connectors that attach one or more edges of the sides of the flexible substrate together to maintain a shape of the folded flexible substrate.", "6.The electronic gaming die as recited in claim 1, further comprising an expanding foam sealant disposed within an interior of the folded flexible substrate.", "7.The electronic gaming die as recited in claim 1, wherein N equals 4, 6, 8, 10 or 20.8.The electronic gaming die as recited m claim 1, wherein each light emitting diode represents a pip of the electronic gaming die.", "9.The electronic gaming die as recited in claim 1, wherein the number of light emitting diodes are greater than the number of the integer assigned to the side of the flexible substrate such that the number of light emitting diodes are arranged to display a numeric character corresponding to the integer.", "10.The electronic gaming die as recited in claim 1, wherein the enclosure is transparent or semi-transparent.", "11-30.", "(canceled) 31.A method for manufacturing an electronic gaming die comprising the steps of: fabricating a flexible substrate that folds into N sides where N is equal to or greater than 4, wherein each side has an inner face, an outer face and is assigned an integer from 1 to N, a number of light emitting diodes disposed on the outer face of each side of the flexible substrate such that the number of light emitting diodes equals the integer assigned to the side of the flexible substrate, a sensor is disposed on one of the inner faces of the flexible substrate, a processor is disposed on one of the inner faces of the flexible substrate and communicably coupled to the sensor and the one or more light emitting diodes, and a battery is disposed on one of the inner faces of the flexible substrate and electrically connected to the one or more light emitting diodes, the sensor and the processor; providing an enclosure having N sides; folding the flexible substrate such that the folded flexible substrate fits into an interior of the enclosure; inserting the folded flexible substrate into the interior of the enclosure; and sealing the enclosure.", "32.The method as recited in claim 31, wherein the sensor, the processor and the battery are disposed on an outer face of one or more additional sides of the flexible substrate that fold inside the N sides.", "33.The method as recited in claim 31, further comprising the step of placing an insert within an interior of the folded flexible substrate, wherein the insert is sized to maintain a position of the flexible substrate against the interior of the enclosure.", "34.The method as recited in claim 33, wherein the insert is rigid, semi-rigid, or hollow.", "35.The method as recited in claim 31, further comprising the step of attaching one or more edges of the sides of the flexible substrate together to maintain a shape of the folded flexible substrate using an adhesive or one or more connectors.", "36.The method as recited in claim 31, further comprising the step of depositing an expanding foam sealant within an interior of the folded flexible substrate.", "37.The method as recited in claim 31, wherein N equals 4, 6, 8, 10 or 20.38.The method as recited in claim 31, wherein each light emitting diode represents a pip of the electronic gaming die.", "39.The method as recited in claim 31, wherein the number of light emitting diodes are greater than the number of the integer assigned to the side of the flexible substrate such that the number of light emitting diodes are arranged to display a numeric character corresponding to the integer.", "40.The method as recited m claim 31, wherein the enclosure is transparent or semitransparent.", "41-59.", "(canceled)" ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Without limiting the scope of the invention, its background is described in connection with methods for manufacturing 3D objects and structures, more specifically 3D structural electronic, electromagnetic and electromechanical components and devices.", "The recent introduction of MEMs-based accelerometers has enabled many new gaming and commercial electronics applications like enhanced features in cell phones and the Nintendo Wiimote.", "The introduction of the accelerometry into gaming dice has only recently been made possible by this new technology.", "Although a LED-lit 20 sided dice has been sold on websites like Thinkgeek, the electronics involved are basic and only involve one side (the 20) with a pressure sensor." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present invention makes gaming dice more visually stunning and makes the dice outcome more obvious—an important feature in a color and lighting-rich environment such as a casino.", "The present invention is manufactured using 3D printing of dielectric structures with conductive traces serving as electrical interconnects.", "More specifically, the present invention provides an electronic gaming die that includes an enclosure, a flexible substrate, a number of light emitting diodes, a sensor, a processor and a battery.", "The enclosure has N sides where N is equal to or greater than 4.The flexible substrate folds in a manner that leaves it with N sides and fits into an interior of the enclosure, wherein each side has an inner face, an outer face and is assigned an integer from 1 to N. The light emitting diodes are disposed on the outer face of each side of the flexible substrate, wherein the number of light emitting diodes equals the integer assigned to the side of the flexible substrate.", "The sensor is disposed on one of the inner faces of the flexible substrate.", "The processor is disposed on one of the inner faces of the flexible substrate and communicably coupled to the sensor and the one or more light emitting diodes.", "The battery is disposed on one of the inner faces of the flexible substrate and electrically connected to the one or more light emitting diodes, the sensor and the processor.", "In addition, the present invention provides a method for manufacturing an electronic gaming die by first fabricating a flexible substrate.", "The flexible substrate folds into N sides where N is equal to or greater than 4, wherein each side has an inner face, an outer face and is assigned an integer from 1 to N. A number of light emitting diodes disposed on the outer face of each side of the flexible substrate such that the number of light emitting diodes equals the integer assigned to the side of the flexible substrate.", "A sensor is disposed on one of the inner faces of the flexible substrate.", "A processor is disposed on one of the inner faces of the flexible substrate and communicably coupled to the sensor and the one or more light emitting diodes.", "A battery is disposed on one of the inner faces of the flexible substrate and electrically connected to the one or more light emitting diodes, the sensor and the processor.", "Next, an enclosure having N sides is provided and the flexible substrate is folded such that the folded flexible substrate fits into an interior of the enclosure.", "The folded flexible substrate is inserted into the interior of the enclosure and the enclosure is sealed.", "This method can be implemented as a computer program embodied on a non-transitory computer readable medium wherein the steps are preformed using one or more code segments." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to U.S.", "Provisional Application Ser.", "No.", "61/845,334, filed Jul.", "11, 2013, the entire contents of which are incorporated herein by reference.", "STATEMENT OF FEDERALLY FUNDED RESEARCH Not Applicable.", "REFERENCE TO A SEQUENCE LISTING Not Applicable.", "TECHNICAL FIELD OF THE INVENTION The present invention relates in general to the manufacture of electronic, electromagnetic and electromechanical components and devices, and more particularly to an electronic gaming die.", "BACKGROUND OF THE INVENTION Without limiting the scope of the invention, its background is described in connection with methods for manufacturing 3D objects and structures, more specifically 3D structural electronic, electromagnetic and electromechanical components and devices.", "The recent introduction of MEMs-based accelerometers has enabled many new gaming and commercial electronics applications like enhanced features in cell phones and the Nintendo Wiimote.", "The introduction of the accelerometry into gaming dice has only recently been made possible by this new technology.", "Although a LED-lit 20 sided dice has been sold on websites like Thinkgeek, the electronics involved are basic and only involve one side (the 20) with a pressure sensor.", "SUMMARY OF THE INVENTION The present invention makes gaming dice more visually stunning and makes the dice outcome more obvious—an important feature in a color and lighting-rich environment such as a casino.", "The present invention is manufactured using 3D printing of dielectric structures with conductive traces serving as electrical interconnects.", "More specifically, the present invention provides an electronic gaming die that includes an enclosure, a flexible substrate, a number of light emitting diodes, a sensor, a processor and a battery.", "The enclosure has N sides where N is equal to or greater than 4.The flexible substrate folds in a manner that leaves it with N sides and fits into an interior of the enclosure, wherein each side has an inner face, an outer face and is assigned an integer from 1 to N. The light emitting diodes are disposed on the outer face of each side of the flexible substrate, wherein the number of light emitting diodes equals the integer assigned to the side of the flexible substrate.", "The sensor is disposed on one of the inner faces of the flexible substrate.", "The processor is disposed on one of the inner faces of the flexible substrate and communicably coupled to the sensor and the one or more light emitting diodes.", "The battery is disposed on one of the inner faces of the flexible substrate and electrically connected to the one or more light emitting diodes, the sensor and the processor.", "In addition, the present invention provides a method for manufacturing an electronic gaming die by first fabricating a flexible substrate.", "The flexible substrate folds into N sides where N is equal to or greater than 4, wherein each side has an inner face, an outer face and is assigned an integer from 1 to N. A number of light emitting diodes disposed on the outer face of each side of the flexible substrate such that the number of light emitting diodes equals the integer assigned to the side of the flexible substrate.", "A sensor is disposed on one of the inner faces of the flexible substrate.", "A processor is disposed on one of the inner faces of the flexible substrate and communicably coupled to the sensor and the one or more light emitting diodes.", "A battery is disposed on one of the inner faces of the flexible substrate and electrically connected to the one or more light emitting diodes, the sensor and the processor.", "Next, an enclosure having N sides is provided and the flexible substrate is folded such that the folded flexible substrate fits into an interior of the enclosure.", "The folded flexible substrate is inserted into the interior of the enclosure and the enclosure is sealed.", "This method can be implemented as a computer program embodied on a non-transitory computer readable medium wherein the steps are preformed using one or more code segments.", "BRIEF DESCRIPTION OF THE DRAWINGS For a more complete understanding of the features and advantages of the present invention, reference is now made to the detailed description of the invention along with the accompanying figures and in which: FIGS.", "1A and 1B are images showing an exploded view of an electronic gaming die in accordance with one embodiment of the present invention; FIG.", "2 is an image showing the folds of the inner sides of a flexible substrate for an electronic gaming die in accordance with one embodiment of the present invention; FIGS.", "3A and 3B are exploded drawings of an enclosure and insert for an electronic gaming die in accordance with one embodiment of the present invention; FIGS.", "4A and 4B are images showing the outer sides and inner sides, respectively, of a flexible substrate for an electronic gaming die in accordance with one embodiment of the present invention; FIG.", "5 is an image of an enclosure for an electronic gaming die in accordance with one embodiment of the present invention; FIGS.", "6A and 6B are images showing an assembled electronic gaming die with a transparent enclosure in accordance with another embodiment of the present invention; FIG.", "7 is a series of images showing the assembly process for an electronic gaming die in accordance with one embodiment of the present invention; FIG.", "8 is an image of an electronic gaming die in accordance with another embodiment of the present invention fabricated with 3D Printing; FIGS.", "9A and 9B are images showing the outer sides and inner sides, respectively, of a flexible substrate for an electronic gaming die in accordance with another embodiment of the present invention; FIGS.", "10A and 10B are images showing the outer sides and inner sides, respectively, of a flexible substrate for an electronic gaming die in accordance with yet another embodiment of the present invention; FIG.", "11 is a flow chart of a method for manufacturing an electronic gaming die in accordance with one embodiment of the present invention; FIG.", "12 is an image of an electronic gaming die in accordance with another embodiment of the present invention; and FIG.", "13 is an image of a wireless battery charging device with two electronic gaming dice in accordance with another embodiment of the present invention.", "DETAILED DESCRIPTION OF THE INVENTION While the making and using of various embodiments of the present invention are discussed in detail below, it should be appreciated that the present invention provides many applicable inventive concepts that can be embodied in a wide variety of specific contexts.", "The specific embodiments discussed herein are merely illustrative of specific ways to make and use the invention and do not delimit the scope of the invention.", "For example, the present invention is described with respect to the design of a six sided gaming die that includes a microprocessor and accelerometer in order to detect a roll, measure the direction of gravity and illuminate light emitting diodes (LED) on the upward face.", "The present invention, however, is not limited to a six sided gaming die or the specific design examples described herein.", "To facilitate the understanding of this invention, a number of terms are defined below.", "Terms defined herein have meanings as commonly understood by a person of ordinary skill in the areas relevant to the present invention.", "Terms such as “a”, “an,” and “the” are not intended to refer to only a singular entity, but include the general class of which a specific example may be used for illustration.", "The terminology herein is used to describe specific embodiments of the invention, but their usage does not delimit the invention, except as outlined in the claims.", "Now referring to FIGS.", "1A and 1B, images showing an exploded view of an electronic gaming die 100 in accordance with one embodiment of the present invention are shown.", "The electronic gaming die 100 includes an enclosure 102, a flexible substrate 104, light emitting diodes 106, a sensor 108, a processor 110, a battery 112 and an insert 114.The enclosure 102 (made up of main enclosure 102a and enclosure lid or cap 102b) has N sides (1021 to 102N) where N is equal to or greater than 4.In the example shown, N=6.In other embodiments of the present invention, N can equal 4, 6, 8, 10, 20 or more.", "The enclosure 102 can be transparent or semi-transparent.", "Likewise, a portion of the enclosure 102 proximate to the one or more light emitting diodes 106 can be transparent or semi-transparent, and the remainder of the enclosure 102 can be opaque.", "The flexible substrate 104 folds into N sides (see also FIG.", "2) and fits into an interior 116 of the enclosure 102.Each side of the flexible substrate 104 has an inner face (FIG.", "1A; see also FIG.", "4B) and an outer face (FIG.", "1B; see also FIG.", "4A).", "The sensor 108 (preferably a three-axis accelerometer) is disposed on one of the inner faces of the flexible substrate 104.The processor 110 is disposed on one of the inner faces of the flexible substrate 104 and is communicably coupled to the sensor 108 and the one or more light emitting diodes 106.The sensor 108 and processor 110 detect a roll, measure a direction of gravity and illuminate the light emitting diode(s) 106 on the upward face.", "The processor 108 can operate the light emitting diodes 106 is various modes, which can be user configurable.", "For example, the light emitting diodes 106 can stay lit for a specified period of time, or flash to show which side of the enclosure 102 is up when the electronic gaming die 100 stops rolling, etc.", "The battery 112 is disposed on one of the inner faces of the flexible substrate 104 and electrically connected to the one or more light emitting diodes 106, the sensor 108 and the processor 110.The battery 112 can be replaceable or rechargeable.", "For example, an interface 118 (e.g., mini USB-A, mini USB-b, micro USB-A, micro USB-b, etc.)", "can be electrically connected to the battery 112 and accessible from an exterior of the enclosure 102 to recharge the battery 112.Alternatively, a wireless battery recharging circuit (not shown) can be electrically connected to the battery 112 and disposed on one of the inner faces of the flexible substrate 104.Likewise, one or more photovoltaic cells (not shown) can be electrically connected to the battery 112 and disposed on or within the enclosure 102 or the flexible substrate 104.The electronic gaming die 100 may automatically enter a sleep mode whenever one or more sleep conditions occur and remain in the sleep mode until one or more wakeup conditions occur.", "For example, the one or more sleep conditions may include the sensor 108 not detecting motion for a specified period of time, the sensor 108 detecting a specified sleep sequence, the electronic gaming die 100 remains stationary for a specified period of time, etc.", "The sleep sequence can be orienting the dice for at least two seconds with the “one” side held up, followed by the “two”, followed by the “three” and so on, or any other desired sequence.", "The low power mode may involve a staged power down of the electronic gaming die 100 (e.g., component-by-component starting with deactivating the light emitting diodes 106).", "The one or more wakeup conditions may include the sensor 108 detecting motion after the sleep mode has been entered or a specific time period thereafter, the sensor 108 detecting a specified wakeup sequence, the electronic gaming die 100 being “rolled” after the sleep mode has been entered or a specified time period thereafter, etc.", "Now also referring to FIGS.", "3A and 3B, exploded drawings of an enclosure 102 and insert 114 for an electronic gaming die 100 in accordance with one embodiment of the present invention are shown.", "The insert 114 is disposed within an interior 116 of the folded flexible substrate 104 and sized to maintain a position of the flexible substrate 104 against the interior of the enclosure 102.The enclosure 102 may include slots, channels, cavities, recesses, depressions or other inner surface features to accommodate the light emitting diodes 106 or other components disposed on the outer faces of the flexible substrate 104.For example, the enclosure lid or cap 102a in FIGS.", "1A and 1B includes an opening to accommodate the interface 118.Alternatively, the lid or cap 102a can be removable in order to change out the battery 112.Note that that one or more inscriptions can be engraved on the enclosure 102.The insert 114 can be rigid, semi-rigid, or hollow.", "Alternatively, the insert 114 can be eliminated and replace by: (1) an adhesive or one or more connectors that attach one or more edges of the sides of the flexible substrate 104 together to maintain a shape of the folded flexible substrate 104; (2) an expanding foam sealant disposed within an interior of the folded flexible substrate 104; or (3) any other suitable method of maintain a shape of the folded flexible substrate 104.Moreover, the insert 114 can be weighted to balance a weight of the die 100, or unbalance the die 100 to favor a specified orientation (i.e., a loaded die or “cheating” die).", "Referring now to FIGS.", "4A and 4B, images showing the outer faces (4201 to 420N) and inner faces (4401 to 440N), respectively, of a flexible substrate 104 for an electronic gaming die 100 in accordance with one embodiment of the present invention are shown.", "This embodiment and the embodiment shown in FIGS.", "9A and 9B have components on both the outer faces 400 and the inner faces 420 of the flexible substrate 104.In contrast, the embodiment shown in FIGS.", "10A and 10B only has components on the inner faces 420 of the flexible substrate 104, which substantially reduces the manufacturing cost.", "Each side 400 of the flexible substrate 104 is assigned an integer from 1 to N (e.g., 4001 to 4006).", "A number of light emitting diodes 106 are disposed on the outer face 420 of each side 400 of the flexible substrate 104.The number of light emitting diodes 106 equals the integer assigned to the side 400 of the flexible substrate 104 and the corresponding side of the enclosure 102.For example and as shown in FIG.", "4A, the first outer face 4201 of the first side 4001 of the flexible substrate 104 has one light emitting diode D1, the second outer face 4202 of the second side 4002 of the flexible substrate 104 has two light emitting diodes D2-D3, the third outer face 4203 of the third side 4003 of the flexible substrate 104 has three light emitting diodes D4-D6, the fourth outer face 4204 of the fourth side 4004 of the flexible substrate 104 has four light emitting diodes D7-D10, the fifth outer face 4205 of the fifth side 4005 of the flexible substrate 104 has five light emitting diodes D11-D15, and the sixth outer face 4206 of the sixth side 4006 of the flexible substrate 104 has six light emitting diodes D16-D21.Each light emitting diode D1-D21 represents a pip of the electronic gaming die 100.Alternatively, the number of light emitting diodes 106 can be greater than the number of the integer assigned to the side 400 of the flexible substrate 104 such that the number of light emitting diodes 106 are arranged to display a numeric character corresponding to the integer.", "As shown in FIG.", "4B, the sensor 108 and processor 110 are disposed on one of the inner faces (e.g., 4401) of the flexible substrate 104.Two leads 402 are used to connect the circuit to the battery 112 (not shown).", "An additional side 404 is used to mount the interface 118 (e.g., mini USB-A, mini USB-b, micro USB-A, micro USB-b, etc.)", "and orient the interface 118 to be accessible via the opening 406 in side 4002.As will be appreciated by those skilled in the art, the circuit includes various capacitors Cx, resistors Rx, electrical traces (conductors) and other desired components.", "In addition, one or more inner faces 420 or one or more outer faces 440 of the flexible substrate 104 can be coated with an ultraviolet photocurable polymer to further protect the various components and the flexible substrate 104.The flexible substrate 104 can be fabricated using traditional flexible circuit board methodologies or fabricated using 3D printing process wherein the electrical conductors that connect the various components are printed conductive traces that can traverse one or more folds of the flexible substrate 104.An example of such a 3D printing system is described in U.S. patent application Ser.", "No.", "13/343,651, which is incorporated by reference in its entirety.", "The three-dimensional printing device creates one or more layers of a three-dimensional substrate by depositing a substrate material in a layer-by-layer fashion.", "The three-dimensional printing device can be a fused deposition modeling machine, a selective laser sintering machine or other suitable device.", "FIG.", "5 is an image of an enclosure 102 for an electronic gaming die 100 in accordance with one embodiment of the present invention.", "FIGS.", "6A and 6B are images showing an assembled electronic gaming die 100 with a transparent enclosure 102 in accordance with another embodiment of the present invention.", "FIG.", "7 is a series of images showing the assembly process for an electronic gaming die 100 in accordance with one embodiment of the present invention.", "FIG.", "8 is an image of an electronic gaming die 100 in accordance with another embodiment of the present invention.", "As shown in FIG.", "8, the electronic gaming die 100 can also be fabricated with 3D Printing technology in conjunction with micro-dispensing of conductive inks serving as electrical interconnect.", "3D Printing of the structure can allow for rapid prototyping not just of the structure but also for the electronic functionality as demonstrated in FIG.", "8.3D Printing can thus allow for faster evaluation of form and function at an unprecedented level.", "Referring now to FIGS.", "9A and 9B, images showing the outer faces (4201 to 420N) and inner faces (4401 to 440N), respectively, of a flexible substrate 104 for an electronic gaming die 100 in accordance with another embodiment of the present invention are shown.", "Like FIGS.", "4A and 4B, this embodiment has components on both the outer faces 400 and the inner faces 420 of the flexible substrate 104.This embodiment does, not however, show the battery leads 402 or interface 118 (e.g., mini USB-A, mini USB-b, micro USB-A, micro USB-b, etc.).", "Each side 400 of the flexible substrate 104 is assigned an integer from 1 to N (e.g., 4001 to 4006).", "A number of light emitting diodes 106 are disposed on the outer face 420 of each side 400 of the flexible substrate 104.The number of light emitting diodes 106 equals the integer assigned to the side 400 of the flexible substrate 104 and the corresponding side of the enclosure 102.For example and as shown in FIG.", "9A, the first outer face 4201 of the first side 4001 of the flexible substrate 104 has one light emitting diode D1, the second outer face 4202 of the second side 4002 of the flexible substrate 104 has two light emitting diodes D2-D3, the third outer face 4203 of the third side 4003 of the flexible substrate 104 has three light emitting diodes D4-D6, the fourth outer face 4204 of the fourth side 4004 of the flexible substrate 104 has four light emitting diodes D7-D10, the fifth outer face 4205 of the fifth side 4005 of the flexible substrate 104 has five light emitting diodes D11-D15, and the sixth outer face 4206 of the sixth side 4006 of the flexible substrate 104 has six light emitting diodes D16-D21.Each light emitting diode D1-D21 represents a pip of the electronic gaming die 100.Alternatively, the number of light emitting diodes 106 can be greater than the number of the integer assigned to the side 400 of the flexible substrate 104 such that the number of light emitting diodes 106 are arranged to display a numeric character corresponding to the integer.", "As shown in FIG.", "9B, the sensor 108 and processor 110 are disposed on one of the inner faces (e.g., 4401) of the flexible substrate 104.As will be appreciated by those skilled in the art, the circuit includes various capacitors Cx, resistors Rx, electrical traces (conductors) and other desired components.", "In addition, one or more inner faces 420 or one or more outer faces 440 of the flexible substrate 104 can be coated with an ultraviolet photocurable polymer to further protect the various components and the flexible substrate 104.The flexible substrate 104 can be fabricated using traditional flexible circuit board methodologies or fabricated using 3D printing process wherein the electrical conductors that connect the various components are printed conductive traces that can traverse one or more folds of the flexible substrate 104.An example of such a 3D printing system is described in U.S. patent application Ser.", "No.", "13/343,651, which is incorporated by reference in its entirety.", "The three-dimensional printing device creates one or more layers of a three-dimensional substrate by depositing a substrate material in a layer-by-layer fashion.", "The three-dimensional printing device can be a fused deposition modeling machine, a selective laser sintering machine or other suitable device.", "Now referring to FIGS.", "10A and 10B, images showing the outer faces (4201 to 420N) and inner faces (4401 to 440N), respectively, of a flexible substrate 104 for an electronic gaming die 100 in accordance with yet another embodiment of the present invention are shown.", "Unlike FIGS.", "4A-B and 9A-B, this embodiment has components only on the outer faces 420 of the flexible substrate 104.This embodiment uses three additional squares or sides 1002, 1004 and 1006 to mount the various components on, such that these three sides 1002, 1004 and 1006 are bent towards the back of the completed flexible substrate 104, leaving the components effectively in the back side again.", "By doing this, the folded flexible substrate inserted into the inside of the cavity 116 of the dice case 102a just like the other embodiments.", "This embodiment greatly reduces the manufacturing price of the flexible substrate 104 (e.g., 40% or more).", "Some of these savings would be offset by the increased handling of the flexible substrate 104 during manufacture, increased time to build each part and increased risk of damaging it through handling.", "Each side 400 of the flexible substrate 104 is assigned an integer from 1 to N (e.g., 4001 to 4006).", "A number of light emitting diodes 106 are disposed on the outer face 420 of each side 400 of the flexible substrate 104.The number of light emitting diodes 106 equals the integer assigned to the side 400 of the flexible substrate 104 and the corresponding side of the enclosure 102.For example and as shown in FIG.", "10A, the first outer face 4201 of the first side 4001 of the flexible substrate 104 has one light emitting diode D1, the second outer face 4202 of the second side 4002 of the flexible substrate 104 has two light emitting diodes D2-D3, the third outer face 4203 of the third side 4003 of the flexible substrate 104 has three light emitting diodes D4-D6, the fourth outer face 4204 of the fourth side 4004 of the flexible substrate 104 has four light emitting diodes D7-D10, the fifth outer face 4205 of the fifth side 4005 of the flexible substrate 104 has five light emitting diodes D11-D15, and the sixth outer face 4206 of the sixth side 4006 of the flexible substrate 104 has six light emitting diodes D16-D21.Each light emitting diode D1-D21 represents a pip of the electronic gaming die 100.Alternatively, the number of light emitting diodes 106 can be greater than the number of the integer assigned to the side 400 of the flexible substrate 104 such that the number of light emitting diodes 106 are arranged to display a numeric character corresponding to the integer.", "The sensor 108 is disposed the outer face (e.g., 4207) of one of the added sides 1002.The processor 110 is disposed on outer face (e.g., 4208) of the one of the added sides 1004.Additional components, such as resistors R4, R5, R7 and R8 are disposed on the outer face (e.g., 4209) of one of the added sides 1006.Two leads 402 are used to connect the circuit to the battery 112 (not shown).", "An additional side 404 is used to mount the interface 118 (e.g., mini USB-A, mini USB-b, micro USB-A, micro USB-b, etc.)", "and orient the interface 118 to be accessible via the opening 406 in side 4002.As will be appreciated by those skilled in the art, the circuit includes various capacitors Cx, resistors Rx, electrical traces (conductors) and other desired components.", "In addition, one or more inner faces 420 or one or more outer faces 440 of the flexible substrate 104 can be coated with an ultraviolet photocurable polymer to further protect the various components and the flexible substrate 104.The flexible substrate 104 can be fabricated using traditional flexible circuit board methodologies or fabricated using 3D printing process wherein the electrical conductors that connect the various components are printed conductive traces that can traverse one or more folds of the flexible substrate 104.An example of such a 3D printing system is described in U.S. patent application Ser.", "No.", "13/343,651, which is incorporated by reference in its entirety.", "The three-dimensional printing device creates one or more layers of a three-dimensional substrate by depositing a substrate material in a layer-by-layer fashion.", "The three-dimensional printing device can be a fused deposition modeling machine, a selective laser sintering machine or other suitable device.", "Now referring to FIG.", "11, a flow chart of a method 1100 for manufacturing an electronic gaming die 100 in accordance with one embodiment of the present invention is shown.", "A flexible substrate is fabricated in block 1102.The flexible substrate folds into N sides where N is equal to or greater than 4, wherein each side has an inner face, an outer face and is assigned an integer from 1 to N (e.g., equals 4, 6, 8, 10, 20, etc.).", "A number of light emitting diodes disposed on the outer face of each side of the flexible substrate such that the number of light emitting diodes equals the integer assigned to the side of the flexible substrate.", "A sensor is disposed on one of the inner faces of the flexible substrate.", "A processor is disposed on one of the inner faces of the flexible substrate and communicably coupled to the sensor and the one or more light emitting diodes.", "A battery is disposed on one of the inner faces of the flexible substrate and electrically connected to the one or more light emitting diodes, the sensor and the processor.", "An enclosure having N sides in provided in block 1104.The flexible substrate is folded in block 1106 such that the folded flexible substrate fits into an interior of the enclosure.", "The folded flexible substrate is inserted into the interior of the enclosure in block 1108 and the enclosure is sealed in block 1110.As previously described, the shape of the folded flexible substrate can be maintained by: placing an insert within an interior of the folded flexible substrate; attaching one or more edges of the sides of the flexible substrate together using an adhesive or one or more connectors; or depositing an expanding foam sealant within an interior of the folded flexible substrate.", "In addition, one or more inner faces or one or more outer faces of the flexible substrate can be coated with an ultraviolet photocurable polymer to further protect the various components and the flexible substrate.", "Moreover, this method can be implemented as a computer program embodied on a non-transitory computer readable medium wherein the steps are preformed using one or more code segments.", "As previously mentioned, the flexible substrate can be fabricated using a conductive ink micro-dispensing process wherein the electrical conductors that connect the various components are printed conductive traces that can traverse one or more folds of the flexible substrate 104.An example of such a 3D printing system is described in U.S. patent application Ser.", "No.", "13/343,651, which is incorporated by reference in its entirety.", "The three-dimensional printing device creates one or more layers of a three-dimensional substrate by depositing a substrate material in a layer-by-layer fashion.", "The three-dimensional printing device can be a fused deposition modeling machine, a selective laser sintering machine or other suitable device.", "Other machines may include a micro-machining machine, a CNC micro-machining machine, a micro electrical discharge machining machine, an electrochemical machining machine, a direct write proton micro-machining machine, a laser ablation machine, a radiative source, an ultrasonic cutting machine, a hot wire cutting machine, a waterjet machine, an etching machine, a deep reactive ion etching machine, a plasma etching machine, a crystal orientation dependent etching machine, a wet bulk micromachining machine, a UV-lithography or X-ray lithography (LIGA) machine, a hot embossing lithography machine, a precision mechanical sawing machine, a chemically assisted ion milling machine, a sand blasting machine or a cutting machine.", "A component placement machine can be used to place and assemble the various components.", "In addition, the system may include a slide, a conveyor or a robotic device that transports the components and electronic gaming die to each machine.", "Note that all of the machines can be integrated into a single machine.", "The substrate material can be a thermoplastic material, another polymer material, a ceramic material, a metallic material, a mineral material, a glass ceramic material, a semi-conductor material, a nanomaterial, a biomaterial, an organic material, an inorganic material or any combination thereof.", "The thermoplastic material can be acrylonitrile butadiene styrene (ABS), ABSi, ABSplus, ABS-M30, ABS-M30i, polycarbonate (PC), PC-ABS, PC-ISO, polyphenylsulfone (PPSF/PPSU), ULTEM 9085 or any combination thereof.", "The another polymer material can be poly(methyl methacrylate) (PMMA), polypropylene, polyolefin, LL-PE, HDPE, polyvinyl acetate, polyester, polyamides, nylon, polyimides, polyketone, polyether ethyl ketone (PEEK), polybutadiene, polylactic acid, polycaprolactone, polyethylene terephthalate, liquid crystalline polymer (LCP), polystyrene, polyvinyl chloride, polyfluoroethylene, polydifluoroethylene, polytetrafluoroethylene, ZEONEX RS420, Eccostock HIK-TPO, co-polymers and block co-polymers of the previous, or any combination thereof.", "FIG.", "12 is an image of an electronic gaming die 100 in accordance with another embodiment of the present invention.", "FIG.", "13 is an image of a wireless battery charging device 1300 with two electronic gaming dice 100a and 100b in accordance with another embodiment of the present invention.", "It may be understood that particular embodiments described herein are shown by way of illustration and not as limitations of the invention.", "The principal features of this invention can be employed in various embodiments without departing from the scope of the invention.", "Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, numerous equivalents to the specific procedures described herein.", "Such equivalents are considered to be within the scope of this invention and are covered by the claims.", "All publications, patents and patent applications mentioned in the specification are indicative of the level of skill of those skilled in the art to which this invention pertains.", "All publications, patents and patent applications are herein incorporated by reference to the same extent as if each individual publication, patent or patent application was specifically and individually indicated to be incorporated by reference.", "The use of the word “a” or “an” when used in conjunction with the term “comprising” in the claims and/or the specification may mean “one,” but it is also consistent with the meaning of “one or more,” “at least one,” and “one or more than one.” The use of the term “or” in the claims is used to mean “and/or” unless explicitly indicated to refer to alternatives only or the alternatives are mutually exclusive, although the disclosure supports a definition that refers to only alternatives and “and/or.” Throughout this application, the term “about” is used to indicate that a value includes the inherent variation of error for the device, the method being employed to determine the value, or the variation that exists among the study subjects.", "As used in this specification and claim(s), the words “comprising” (and any form of comprising, such as “comprise” and “comprises”), “having” (and any form of having, such as “have” and “has”), “including” (and any form of including, such as “includes” and “include”) or “containing” (and any form of containing, such as “contains” and “contain”) are inclusive or open-ended and do not exclude additional, unrecited elements or method steps.", "The term “or combinations thereof” as used herein refers to all permutations and combinations of the listed items preceding the term.", "For example, “A, B, C, or combinations thereof” is intended to include at least one of: A, B, C, AB, AC, BC, or ABC, and if order is important in a particular context, also BA, CA, CB, CBA, BCA, ACB, BAC, or CAB.", "Continuing with this example, expressly included are combinations that contain repeats of one or more item or term, such as BB, AAA, AB, BBC, AAABCCCC, CBBAAA, CABABB, and so forth.", "The skilled artisan will understand that typically there is no limit on the number of items or terms in any combination, unless otherwise apparent from the context.", "All of the compositions and/or methods disclosed and claimed herein can be made and executed without undue experimentation in light of the present disclosure.", "While the compositions and methods of this invention have been described in terms of preferred embodiments, it may be apparent to those of skill in the art that variations may be applied to the compositions and/or methods and in the steps or in the sequence of steps of the method described herein without departing from the concept, spirit and scope of the invention.", "All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims." ] ]
Patent_15876084
[ [ "TREATMENT OF GLYCOGEN STORAGE DISEASE TYPE II", "Methods of treating glycogen storage disease type II, by administering acid α-glucosidase, are described, as are compositions for use in treatment of glycogen storage disease type II." ], [ "1.A method of treating glycogen storage disease type II in a human individual having glycogen storage disease type II, comprising administering to the individual a therapeutically effective amount of a precursor form of human acid α-glucosidase produced in Chinese hamster ovary cell culture (CHO GAA) at a regular interval, wherein said precursor form is administered in conjunction with an immunosuppressive or immunotherapeutic regimen, and wherein said immunosuppressive or immunotherapeutic regimen is administered prior to any administration of said precursor form.", "2.The method of claim 1, wherein said precursor form is administered monthly, bimonthly, weekly, twice weekly or daily.", "3.The method of claim 2, wherein said precursor form is administered bimonthly.", "4.The method of claim 1, wherein said precursor form is administered intravenously, intramuscularly, intrathecally or intraventricularly.", "5.The method of claim 1, wherein the glycogen storage disease type II is infantile glycogen storage disease type II, juvenile glycogen storage disease type II, or adult-onset glycogen storage disease type II.", "6.The method of claim 5, wherein the glycogen storage disease type II is infantile glycogen storage disease type II.", "7.The method of claim 1, wherein the method comprises treating cardiomyopathy associated with glycogen storage disease type II in a human in need of such treatment.", "8.The method of claim 1, wherein less than 15 mg of said precursor form per kilogram of body weight is administered.", "9.The method of claim 5, wherein 1 to 10 mg of said precursor form per kilogram of body weight is administered." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Glycogen storage disease type II (GSD-II) (also known as Pompe disease or acid maltase deficiency) is a fatal genetic muscle disorder caused by a deficiency of acid α-glucosidase (GAA), a glycogen degrading lysosomal enzyme (Hirschhorn, R., “Glycogen storage disease type II: acid α-glucosidase (acid maltase) deficiency”, in Scriver, C. R. et al., (eds) The Metabolic and Molecular Basis of Inherited disease, 7 th Ed., McGraw-Hill, New York, 1995, pp.", "2443-2464).", "The deficiency results in lysosomal glycogen accumulation in almost all tissues of the body, with cardiac and skeletal muscle being the most seriously affected.", "The combined incidence of all forms of GSD-II is estimated to be 1:40,000, and the disease affects all groups without an ethnic predilection (Martiniuk, F. et al., Amer.", "J. Med.", "Genet.", "79:69-72 (1998); Ausems, M.G.E.M.", "et al., Eur.", "J. Hum.", "Genet.", "7:713-716 (1999)).", "Clinically, GSD-II encompasses a range of phenotypes differing as to age of onset, organs involved and clinical severity, generally correlating with the residual amount of GAA activity.", "In its most severe presentation (infantile GSD-II, or Pompe disease, in which less than 1% of normal GAA activity is present), infants are affected by a hypertrophic cardiomyopathy, generalized muscle weakness and hypotonia secondary to massive glycogen accumulation in cardiac and skeletal muscles (for review, see Hirschhorn, supra ).", "The disease progresses rapidly, with death from cardiac failure usually occurring by 1 year of age.", "Juvenile (1-10% of normal GAA activity) and adult-onset (10-40% of normal GAA activity) forms of the disease are characterized by lack of severe cardiac involvement, later age of onset, and slower progression, but eventual respiratory or limb muscle involvement results in significant morbidity and mortality for the affected individuals.", "Drug treatment strategies, dietary manipulations, and bone marrow transplantation have been employed as means for treatment for GSD-II, without significant success (Hug, G. et al., Birth Defects Org.", "Ser.", "9:160-183 (1967); Slonim, A. E. et al., Neurology 33:34 (1983); Watson, J. G. et al., N. Engl.", "J. Med.", "314:385 (1986)).", "Early attempts at enzyme replacement were also unsuccessful (Hug, G. and Schubert, W. K., J. Clin.", "Invest.", "46:1073 (1967); de Barsy, T. et al., Birth Defects Orig.", "Art.", "Ser.", "9:84-190 (1973); Williams, J. C. and Murray, A. K., “Enzyme replacement in Pompe disease with an alpha glucosidase low-density lipoprotein complex”, in Desnick, R. J.", "(ed), Enzyme Therapy in Genetic Diseases: 2, New York, Alan R. Liss 1980; pp.", "415-423)).", "A need remains for effective treatment of GSD-II." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present invention is drawn to methods of treating glycogen storage disease type II (infantile, juvenile or adult-onset) in an individual, by administering to the individual a therapeutically effective amount of acid α-glucosidase (e.g., less than about 15 mg enzyme per kilogram of body weight, preferably about 1-10 mg enzyme per kilogram of body weight more preferably about 10 enzyme per kilogram of body weight or about 5 mg enzyme per kilogram of body weight), at a regular interval (e.g., monthly, bimonthly, weekly, twice weekly, daily).", "The acid α-glucosidase is human acid, α-glucosidase, preferably recombinant human acid α-glucosidase, more preferably, precursor form of human acid α-glucosidase, and even more preferably precursor form of human acid α-glucosidase produced in Chinese hamster ovary cells.", "The acid α-glucosidase is administered periodically (e.g., monthly, bimonthly, weekly, twice weekly, daily).", "In preferred embodiments, the acid α-glucosidase is administered intravenously; intramuscularly; intrathecally; or intraventricularly.", "The methods of the invention provide the first effective means to treat an individual with glycogen storage disease type II." ], [ "This application is a continuation of U.S. application Ser.", "No.", "13/593,148 (published as U.S. 2013-0195834 A1), filed Aug. 23, 2012 (allowed), which is a continuation of U.S. application Ser.", "No.", "13/064,556, filed Mar.", "30, 2011 (abandoned), which is a continuation of U.S. application Ser.", "No.", "12/604,267, filed Oct. 22, 2009 (abandoned), which is a continuation of U.S. application Ser.", "No.", "11/889,457, filed Aug. 13, 2007 (abandoned), which is a continuation of U.S. application Ser.", "No.", "11/039,281, filed Jan. 20, 2005 (abandoned), which is a continuation of U.S. application Ser.", "No.", "09/902,461, filed Jul.", "10, 2001 (issued as U.S. Pat.", "No.", "7,056,712), which claims the benefit of U.S.", "Provisional Application No.", "60/219,237, filed Jul.", "18, 2000, the entire contents of each of which are hereby incorporated by reference in this application.", "BACKGROUND OF THE INVENTION Glycogen storage disease type II (GSD-II) (also known as Pompe disease or acid maltase deficiency) is a fatal genetic muscle disorder caused by a deficiency of acid α-glucosidase (GAA), a glycogen degrading lysosomal enzyme (Hirschhorn, R., “Glycogen storage disease type II: acid α-glucosidase (acid maltase) deficiency”, in Scriver, C. R. et al., (eds) The Metabolic and Molecular Basis of Inherited disease, 7th Ed., McGraw-Hill, New York, 1995, pp.", "2443-2464).", "The deficiency results in lysosomal glycogen accumulation in almost all tissues of the body, with cardiac and skeletal muscle being the most seriously affected.", "The combined incidence of all forms of GSD-II is estimated to be 1:40,000, and the disease affects all groups without an ethnic predilection (Martiniuk, F. et al., Amer.", "J. Med.", "Genet.", "79:69-72 (1998); Ausems, M.G.E.M.", "et al., Eur.", "J. Hum.", "Genet.", "7:713-716 (1999)).", "Clinically, GSD-II encompasses a range of phenotypes differing as to age of onset, organs involved and clinical severity, generally correlating with the residual amount of GAA activity.", "In its most severe presentation (infantile GSD-II, or Pompe disease, in which less than 1% of normal GAA activity is present), infants are affected by a hypertrophic cardiomyopathy, generalized muscle weakness and hypotonia secondary to massive glycogen accumulation in cardiac and skeletal muscles (for review, see Hirschhorn, supra).", "The disease progresses rapidly, with death from cardiac failure usually occurring by 1 year of age.", "Juvenile (1-10% of normal GAA activity) and adult-onset (10-40% of normal GAA activity) forms of the disease are characterized by lack of severe cardiac involvement, later age of onset, and slower progression, but eventual respiratory or limb muscle involvement results in significant morbidity and mortality for the affected individuals.", "Drug treatment strategies, dietary manipulations, and bone marrow transplantation have been employed as means for treatment for GSD-II, without significant success (Hug, G. et al., Birth Defects Org.", "Ser.", "9:160-183 (1967); Slonim, A. E. et al., Neurology 33:34 (1983); Watson, J. G. et al., N. Engl.", "J. Med.", "314:385 (1986)).", "Early attempts at enzyme replacement were also unsuccessful (Hug, G. and Schubert, W. K., J. Clin.", "Invest.", "46:1073 (1967); de Barsy, T. et al., Birth Defects Orig.", "Art.", "Ser.", "9:84-190 (1973); Williams, J. C. and Murray, A. K., “Enzyme replacement in Pompe disease with an alpha glucosidase low-density lipoprotein complex”, in Desnick, R. J.", "(ed), Enzyme Therapy in Genetic Diseases: 2, New York, Alan R. Liss 1980; pp.", "415-423)).", "A need remains for effective treatment of GSD-II.", "SUMMARY OF THE INVENTION The present invention is drawn to methods of treating glycogen storage disease type II (infantile, juvenile or adult-onset) in an individual, by administering to the individual a therapeutically effective amount of acid α-glucosidase (e.g., less than about 15 mg enzyme per kilogram of body weight, preferably about 1-10 mg enzyme per kilogram of body weight more preferably about 10 enzyme per kilogram of body weight or about 5 mg enzyme per kilogram of body weight), at a regular interval (e.g., monthly, bimonthly, weekly, twice weekly, daily).", "The acid α-glucosidase is human acid, α-glucosidase, preferably recombinant human acid α-glucosidase, more preferably, precursor form of human acid α-glucosidase, and even more preferably precursor form of human acid α-glucosidase produced in Chinese hamster ovary cells.", "The acid α-glucosidase is administered periodically (e.g., monthly, bimonthly, weekly, twice weekly, daily).", "In preferred embodiments, the acid α-glucosidase is administered intravenously; intramuscularly; intrathecally; or intraventricularly.", "The methods of the invention provide the first effective means to treat an individual with glycogen storage disease type II.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1A-1C are a series of graphic representations depicting longitudinal data (for the first 16 months of age) on motor development as assessed by Alberta Infant Motor Scale (AIMS) (closed diamonds), and titer of antibodies to recombinant human acid α-glucosidase (rhGAA) (open diamonds) in three patients (patient 1, FIG.", "1A; patient 2, FIG.", "1B; patient 3, FIG.", "1C) with infantile Pompe disease receiving enzyme replacement therapy.", "The arrow indicates when the enzyme therapy was initiated.", "AIMS scores in normal patients are plotted as dotted curves against age (5th, 10th, 25th, 50th, 75th and 95th percentile, from bottom to top).", "FIG.", "2A-2F are a series of graphic representations depicting longitudinal two-dimensional echocardiographic measurements of left ventricular volume (FIG.", "2A-2C) and mass (FIG.", "2D-2F) in the three infantile Pompe disease patients receiving enzyme replacement therapy (patient 1, FIG.", "2A and 2D; patient 2, FIG.", "2B and 2E; patient 3, FIG.", "2C and 2F).", "Week 0 depicts the measurements at the time of enzyme therapy initiation.", "Open diamonds, end-diastolic volume measurement; closed diamonds, end-systolic volume measurement.", "DETAILED DESCRIPTION OF THE INVENTION The present invention is drawn to methods of treating glycogen storage disease type II (GSD-II) in an individual, by administering the enzyme, acid α-glucosidase (GAA) to the individual, as well as the use of the enzyme, GAA, in the manufacture of a medicament for the treatment of glycogen storage disease type II.", "As described herein, Applicants have successfully treated infants suffering from GSD-II by administering GAA to the infants on a regular basis; the infants demonstrated improvement of cardiac status, pulmonary function, and neurodevelopment, as well as reduction of glycogen levels in tissue.", "As a result of these findings, it is now possible for the first time to treat GSD-II, including infantile, juvenile and adult-onset GSD-II.", "Although the results described herein discuss individuals with the most severe form of GSD-II (infantile GSD-II), it is expected that the methods will be equally effective in individuals affected by juvenile or adult-onset GSD-II, and may, in fact, be even more effective, as individuals with juvenile or adult-onset GSD-II have higher levels of residual GAA activity (1-10%, or 10-40%, respectively), and therefore are likely to be more immunologically tolerant of the administered GAA (e.g., they are generally cross-reactive immunoreactive material (CRIM)-positive for endogenous GAA, so that their immune systems do not perceive the GAA as a “foreign” protein, and they do not develop anti-GAA antibodies).", "The enhanced efficacy in such individuals can be seen in patient 3, who was CRIM-positive and did not develop anti-GAA antibodies, and who demonstrated a normal progression of developmental milestones, in contrast with the variable course that was seen in CRIM-negative patients 1 and 2 (who did develop anti-GAA antibodies).", "The terms, “treat” and “treatment,” as used herein, refer to amelioration of one or more symptoms associated with the disease, prevention or delay of the onset of one or more symptoms of the disease, and/or lessening of the severity or frequency of one or more symptoms of the disease.", "For example, treatment can refer to improvement of cardiac status (e.g., increase of end-diastolic and/or end-systolic volumes, or reduction, amelioration or prevention of the progressive cardiomyopathy that is typically found in GSD-II) or of pulmonary function (e.g., increase in crying vital capacity over baseline capacity, and/or normalization of oxygen desaturation during crying); improvement in neurodevelopment and/or motor skills (e.g., increase in AIMS score); reduction of glycogen levels in tissue of the individual affected by the disease; or any combination of these effects.", "In one preferred embodiment, treatment includes improvement of cardiac status, particularly in reduction or prevention of GSD-II-associated cardiomyopathy.", "The terms, “improve,” “increase” or “reduce,” as used herein, indicate values that are relative to a baseline measurement, such as a measurement in the same individual prior to initiation of the treatment described herein, or a measurement in a control individual (or multiple control individuals) in the absence of the treatment described herein.", "A control individual is an individual afflicted with the same form of GSD-II (either infantile, juvenile or adult-onset) as the individual being treated, who is about the same age as the individual being treated (to ensure that the stages of the disease in the treated individual and the control individual(s) are comparable).", "The individual being treated is an individual (fetus, child, adolescent, or adult human) having GSD-II (i.e., either infantile GSD-II, juvenile GSD-II, or adult-onset GSD-II).", "The individual can have residual GAA activity, or no measurable activity.", "For example, the individual having GSD-II can have GAA activity that is less than about 1% of normal GAA activity (infantile GSD-II), GAA activity that is about 1-10% of normal GAA activity (juvenile GSD-II), or GAA activity that is about 10-40% of normal GAA activity (adult GSD-II).", "The individual can be CRIM-positive or CRIM-negative for endogenous GAA.", "In a preferred embodiment, the individual is CRIM-positive for endogenous GAA.", "In another preferred embodiment, the individual is an individual who has been recently diagnosed with the disease.", "Early treatment (treatment commencing as soon as possible after diagnosis) is important for to minimize the effects of the disease and to maximize the benefits of treatment.", "In the methods of the invention, human acid α-glucosidase (GAA) is administered to the individual.", "The GAA is in a form that, when administered, targets tissues such as the tissues affected by the disease (e.g., heart, muscle).", "In one preferred embodiment, the human GAA is administered in its precursor form, as the precursor contains motifs which allow efficient receptor-mediated uptake of GAA.", "Alternatively, a mature form of human GAA that has been modified to contain motifs to allow efficient uptake of GAA, can be administered.", "In a particularly preferred embodiment, the GAA is the precursor form of recombinant human GAA.", "GAA is obtainable from a variety of sources.", "In a particularly preferred embodiment, recombinant human acid α-glucosidase (rhGAA) has been produced in Chinese hamster ovary (CHO) cell cultures is used (see, e.g., Fuller, M. et al., Eur.", "J. Biochem.", "234:903-909 (1995); Van Hove, J. L. K. et al., Proc.", "Natl.", "Acad.", "Sci.", "USA 93:65-70 (1996); the entire teachings of these references are incorporated herein by reference).", "Production of GAA in CHO cells appears to yield a product having glycosylation which allows significant and efficient uptake of GAA in the desired tissues (heart and muscle); it is assumed that the glycosylation differs from that of GAA that is produced in transgenic mouse and rabbit milk (see, e.g., Bijvoet, A. G. A. et al., Hum.", "Mol.", "Genet.", "7:1815-1824 (1998); Bijvoet, A. G. A. et al., Hum.", "Mol.", "Genet.", "8:2145-2153 (1999)).", "The GAA has a specific enzyme activity in the range of about 1.0-3.5 μmol/min/mg protein, preferably in the range of about 2-3.5 μmol/min/mg protein.", "In one preferred embodiment, the GAA has a specific enzyme activity of at least about 1.0 μmol/min/mg protein; more preferably, a specific enzyme activity of at least about 2.0 μmol/min/mg protein; even more preferably, a specific enzyme activity of at least about 2.5 μmol/min/mg protein; and still more preferably, a specific enzyme activity of at least about 2.75 μmol/min/mg protein.", "GAA can be administered alone, or in compositions or medicaments comprising the GAA (e.g., in the manufacture of a medicament for the treatment of the disease), as described herein.", "The compositions can be formulated with a physiologically acceptable carrier or excipient to prepare a pharmaceutical composition.", "The carrier and composition can be sterile.", "The formulation should suit the mode of administration.", "Suitable pharmaceutically acceptable carriers include but are not limited to water, salt solutions (e.g., NaCl), saline, buffered saline, alcohols, glycerol, ethanol, gum arable, vegetable oils, benzyl alcohols, polyethylene glycols, gelatin, carbohydrates such as lactose, amylose or starch, sugars such as mannitol, sucrose, or others, dextrose, magnesium stearate, talc, silicic acid, viscous paraffin, perfume oil, fatty acid esters, hydroxymethylcellulose, polyvinyl pyrolidone, etc., as well as combinations thereof.", "The pharmaceutical preparations can, if desired, be mixed with auxiliary agents, e.g., lubricants, preservatives, stabilizers, wetting agents, emulsifiers, salts for influencing osmotic pressure, buffers, coloring, flavoring and/or aromatic substances and the like which do not deleteriously react with the active compounds.", "In a preferred embodiment, a water-soluble carrier suitable for intravenous administration is used.", "The composition or medicament, if desired, can also contain minor amounts of wetting or emulsifying agents, or pH buffering agents.", "The composition can be a liquid solution, suspension, emulsion, tablet, pill, capsule, sustained release formulation, or powder.", "The composition can also be formulated as a suppository, with traditional binders and carriers such as triglycerides.", "Oral formulation can include standard carriers such as pharmaceutical grades of mannitol, lactose, starch, magnesium stearate, polyvinyl pyrollidone, sodium saccharine, cellulose, magnesium carbonate, etc.", "The composition or medicament can be formulated in accordance with the routine procedures as a pharmaceutical composition adapted for administration to human beings.", "For example, in a preferred embodiment, a composition for intravenous administration typically is a solution in sterile isotonic aqueous buffer.", "Where necessary, the composition may also include a solubilizing agent and a local anesthetic to ease pain at the site of the injection.", "Generally, the ingredients are supplied either separately or mixed together in unit dosage form, for example, as a dry lyophilized powder or water free concentrate in a hermetically sealed container such as an ampule or sachette indicating the quantity of active agent.", "Where the composition is to be administered by infusion, it can be dispensed with an infusion bottle containing sterile pharmaceutical grade water, saline or dextrose/water.", "Where the composition is administered by injection, an ampule of sterile water for injection or saline can be provided so that the ingredients may be mixed prior to administration.", "The GAA can be formulated as neutral or salt forms.", "Pharmaceutically acceptable salts include those formed with free amino groups such as those derived from hydrochloric, phosphoric, acetic, oxalic, tartaric acids, etc., and those formed with free carboxyl groups such as those derived from sodium, potassium, ammonium, calcium, ferric hydroxides, isopropylamine, triethylamine, 2-ethylamino ethanol, histidine, procaine, etc.", "GAA (or composition or medicament containing GAA) is administered by an appropriate route.", "In one embodiment, the GAA is administered intravenously.", "In other embodiments, GAA is administered by direct administration to a target tissue, such as heart or muscle (e.g., intramuscular), or nervous system (e.g., direct injection into the brain; intraventricularly; intrathecally).", "More than one route can be used concurrently, if desired.", "GAA (or composition or medicament containing GAA) can be administered alone, or in conjunction with other agents, such as antihistamines (e.g., diphenhydramine) or immunosuppressants or other immunotherapeutic agents which counteract anti-GAA antibodies.", "The term, “in conjunction with,” indicates that the agent is administered at about the same time as the GAA (or composition containing GAA).", "For example, the agent can be mixed into a composition containing GAA, and thereby administered contemporaneously with the GAA; alternatively, the agent can be administered contemporaneously, without mixing (e.g., by “piggybacking” delivery of the agent on the intravenous line by which the GAA is also administered, or vice versa).", "In another example, the agent can be administered separately (e.g., not admixed), but within a short time frame (e.g., within 24 hours) of administration of the GAA.", "In one preferred embodiment, if the individual is CRIM-negative for endogenous GAA, GAA (or composition containing GAA) is administered in conjunction with an immunosuppressive or immunotherapeutic regimen designed to reduce amounts of, or prevent production of, anti-GAA antibodies.", "For example, a protocol similar to those used in hemophilia patients (Nilsson, I. M. et al., N. Engl.", "J. Med.", "318:947-50 (1988)) can be used to reduce anti-GAA antibodies.", "Such a regimen can also be used in individuals who are CRIM-positive for endogenous GAA but who have, or are at risk of having, anti-GAA antibodies.", "In a particularly preferred embodiment, the immunosuppressive or immunotherapeutic regimen is begun prior to the first administration of GAA, in order to minimize the possibility of production of anti-GAA antibodies.", "GAA (or composition or medicament containing GAA) is administered in a therapeutically effective amount (i.e., a dosage amount that, when administered at regular intervals, is sufficient to treat the disease, such as by ameliorating symptoms associated with the disease, preventing or delaying the onset of the disease, and/or also lessening the severity or frequency of symptoms of the disease, as described above).", "The amount which will be therapeutically effective in the treatment the disease will depend on the nature and extent of the disease's effects, and can be determined by standard clinical techniques.", "In addition, in vitro or in vivo assays may optionally be employed to help identify optimal dosage ranges.", "The precise dose to be employed will also depend on the route of administration, and the seriousness of the disease, and should be decided according to the judgment of a practitioner and each patient's circumstances.", "Effective doses may be extrapolated from dose-response curves derived from in vitro or animal model test systems.", "In a preferred embodiment, the therapeutically effective amount is less than about 15 mg enzyme/kg body weight of the individual, preferably in the range of about 1-10 mg enzyme/kg body weight, and even more preferably about 10 mg enzyme/kg body weight or about 5 mg enzyme/kg body weight.", "The effective dose for a particular individual can be varied (e.g., increased or decreased) over time, depending on the needs of the individual.", "For example, in times of physical illness or stress, or if anti-GAA antibodies become present or increase, or if disease symptoms worsen, the amount can be increased.", "The therapeutically effective amount of GAA (or composition or medicament containing GAA) is administered at regular intervals, depending on the nature and extent of the disease's effects, and on an ongoing basis.", "Administration at a “regular interval,” as used herein, indicates that the therapeutically effective amount is administered periodically (as distinguished from a one-time dose).", "The interval can be determined by standard clinical techniques.", "In preferred embodiments, GAA is administered monthly, bimonthly; weekly; twice weekly; or daily.", "The administration interval for a single individual need not be a fixed interval, but can be varied over time, depending on the needs of the individual.", "For example, in times of physical illness or stress, if anti-GAA antibodies become present or increase, or if disease symptoms worsen, the interval between doses can be decreased.", "In one preferred embodiment, a therapeutically effective amount of 10 mg enzyme/kg body weight is administered weekly.", "In another preferred embodiment, a therapeutically effective amount of 5 mg enzyme/kg body weight is administered twice weekly.", "The invention additionally pertains to a pharmaceutical composition comprising human acid α-glucosidase, as described herein, in a container (e.g., a vial, bottle, bag for intravenous administration, syringe, etc.)", "with a label containing instructions for administration of the composition for treatment of glycogen storage disease type II, such as by the methods described herein.", "The invention will be further and more specifically described by the following examples.", "EXEMPLIFICATION Phase I/II Trial of Use of Recombinant Human Acid α-Glucosidase Material and Methods Patients: Inclusion criteria were infants affected with infantile GSD-II having virtually absent GAA.", "activity (<1% of normal in skin fibroblasts and/or muscle biopsy) and less than one year of age.", "Exclusion criteria included severe cardiorespiratory failure at baseline and/or other medical conditions likely to decrease survival.", "Because of the limited life expectancy of the disease following diagnosis, no placebo control was used.", "Historical control data indicated that virtually all patients died before 1 year of age (Table 1).", "TABLE 1 Historical control data of infantile glycogen storage disease, type II Length of disease Onset (months) Death (months) course (months) Duke University Medical Center (n = 30)* Mean ± SD 5.1 ± 1.8 8.6 ± 2.4 3.5 ± 2.3 Range 2.4-10.3 3.3-12.4 0.0-9.0 Slonim et al.", "(n = 10)** Mean ± SD 2.5 ± 1.0 7.2 ± 2.8 4.7 ± 2.4 Range 1.0-4.0 4.0-12.0 2.0-9.0 *Data from Duke University Pompe Disease Registry **Data from Slonim et al., J. Pediatr.", "137: 283-285 (2000).", "Three infants affected with infantile GSD-II as evidenced by reduced acid α-glucosidase activity to less than 1% of normal in skin fibroblasts and/or muscle biopsy were enrolled in the study.", "At the protein level, both patients 1 and 2 had no detectable GAA protein while patient 3 had reduced levels of GAA protein detected by immunoblot analysis.", "The baseline clinical data before the initiation of the therapy are summarized in Table 2.TABLE 2 Baseline Clinical Data on 3 Infantile Pompe Disease Patients Age Motor GAA Activity in Patient Ethnic rhGAA Cardiac Pulmonary Development Skin Fibroblasts CRIM* Current Number/Sex Background Started Status Function (AIMS Score) (% of normal) Status Age Patient Caucasian 4 Severe Borderline normal, <<5th % 0.84% Negative 29 1/male months cardiomyopathy; left main bronchus months states post compression due to cardiac arrest markedly enlarged heart, O2 desaturation Patient African- 3 Moderate O2 desaturation during <5th % 0.57% Negative 25 2/male American months cardiomyopathy crying months Patient Caucasian 2½ Borderline Normal <<5th % 0.69% Positive 23 3/male months cardiomyopathy months *CRIM = cross reactive immunoreactive material Patient 1 presented at 2 months of age with cardiac arrest during elective surgical repair of an inguinal hernia.", "Subsequent evaluation when he was 4 months of age demonstrated evidence of severe hypotonia, with a motor development age estimated to be equivalent to that of a 3 week old.", "He also had profound cardiomyopathy and severe cardiomegaly with compression of the left main bronchus resulting in partial atelectasis of the left lung, and feeding difficulties and failure to thrive.", "Patients 2 and 3 were prenatally diagnosed with Pompe disease; importantly, each had a previous sibling that had died of symptoms typically attributable to the infantile GSD-II.", "Both patients had evidence of motor delays; in addition patient 2 had feeding difficulty, failure to thrive and severe cardiomyopathy.", "Basic Design: The study was designed as a Phase I/II, open-label, single-dose, safety and efficacy study of rhGAA administered twice weekly in the 3 patients with infantile Pompe disease.", "The study was approved by the institutional review board, and parental written informed consent was obtained.", "The study consisted of an initial Screening Phase, a 13-week Treatment Phase, and a Follow-up Treatment Phase.", "During the Screening Phase the initial clinical status of the patients was assessed; in addition, GAA and glycogen levels were determined in skeletal muscle biopsy samples.", "During the Treatment Phase, patients received intravenous infusions of rhGAA (5 mg/kg) twice weekly.", "Patients were closely monitored for any adverse responses to the enzyme infusions, as well as for any impact the rhGAA administrations had on the clinical progression of infantile GSD-II.", "General clinical assessments included routine physical examinations, supplemented by complete urine, hematological, and clinical chemistry analyses (electrolytes, glucose, creatinine, BUN, CO2, protein, albumin, ALT, AST, bilirubin, alkaline phosphatase, CK and isozyme, uric acid).", "Exhaustive neurologic and motor function evaluations included manual muscle strength testing, Denver development testing, and AIMS (Alberta Infant Motor Scale; see Piper, M. C. and Darrah, J., Motor Assessment of the Developing Infant, WB Sanders Company, Philadelphia, 1994).", "Two-dimensional, M-mode and Doppler echocardiography were used to assess left ventricular mass, wall thickness and systolic as well as diastolic functions.", "Additionally, a variety of pulmonary functions (crying vital capacity, trend pulse-oximetry and end tidal carbon dioxide measurement, as well as negative inspiratory force maneuver) were monitored throughout the study.", "At the conclusion of the 13-week treatment phase, GAA activity, glycogen levels and histopathology of muscle biopsies obtained from the quadriceps muscles of the contra-lateral thigh of the pre-treatment biopsies were determined.", "The muscle biopsies were taken 3 days after the rhGAA infusion.", "Enzyme source: rhGAA purified from the culture medium of rhGAA secreting CHO cells (Van Hove, J. L. K. et al., Proc.", "Natl.", "Acad.", "Sci.", "USA 93:65-70 (1996)) was provided as a GMP-grade, sterile and colorless solution by Synpac (North Carolina), Inc., 99 Alexander Drive, Suite NW20, Research Triangle Park, N.C. 27709.rhGAA was purified primarily as the 110-kD precursor protein with specific enzyme activity of 2.77-3.02 μmol/min/mg protein.", "ELISA for anti-rhGAA antibodies: The ELISA for anti-rhGAA antibodies was a standard sandwich assay performed by Phoenix International Life Sciences, Inc. (Saint-Laurent, Quebec).", "Briefly, microtiter plates were coated with rhGAA at 2.0 μg/ml overnight and then blocked with bovine IgG.", "Patient serum, diluted to 1:100 and then serially diluted at 1:2, was reacted with the rhGAA on the plate.", "The amount of bound antibody was detected with a horseradish peroxidase conjugated goat anti-human secondary antibody and tetramethylbenzidine substrate by measuring the absorbances at 450 nm.", "Positive samples were defined as having an absorbance that was higher than the negative cutoff.", "This was defined as twice the A450 value of the normal human serum negative control.", "Titer was defined as the dilution of the serum that still had an A450 reading above the negative cutoff value.", "GAA activity, glycogen content and Western blot analysis: GAA activity was assessed by measurement of 4-methyl-umbelliferyl-α-D-glucoside cleavage at pH 4.3 as previously described (Reuser, A. J. J. et al., Am.", "J. Hum.", "Genet.", "30:132-143 (1978)).", "As an internal standard, acid-β-galactosidase activity was similarly assayed with the 4-methyl-umbilliferyl derivative as the substrate (Wenger, D. A. and Williams, C., “Screening for lysosomal disorders” in Hommes, F. A.", "(ed.", "), Techniques in diagnostic human biochemical genetics: a laboratory manual, Wiley-Liss, New York, 1991, pp.", "587-617).", "Glycogen content was determined by treatment of tissue extracts with A. niger amyloglucosidase and measurement of glucose released (Van Hove, J. L. K. et al., Proc.", "Natl.", "Acad.", "Sci.", "USA 93:65-10 (1996)).", "Western blot analysis was performed with antibody raised in rabbits against purified placenta GAA (Van Hove, J. L. K. et al., supra).", "Histology: One specimen of muscle was mounted on a chuck with gum tragacanth and quick-frozen in isopentane cooled by liquid nitrogen.", "Five micron sections were obtained and stained with hematoxylin and eosin, modified Gomori trichrome, ATPase at pH 4.35 and 9.4, nicotinamide dehydrogenase tetrazolium blue reductase, and phosphorylase.", "A second specimen was clamped in situ and placed in 2.5% glutaraldehyde.", "The tissue was processed without en bloc staining with uranyl acetate in order to avoid loss of glycogen.", "Semithin sections (0.5 micron) were stained with toluidine blue and thin sections stained with uranyl acetate and lead citrate and mounted on a copper grid for electron microscopy.", "RESULTS Patient Reaction to Treatment: The three patients with infantile Pompe disease received twice weekly intravenous infusions of rhGAA for 21-25 months.", "No serious allergic reactions occurred during enzyme therapy.", "However, three episodes of skin rash, accompanied by a mild fever and increased irritability occurred in two of the patients (patient 1 two episodes, patient 2 single episode).", "These symptoms resolved promptly after intravenous administration of diphenhydramine.", "After a second episode of skin rash, patient 1 was premedicated with oral diphenhydramine just prior to all subsequent rhGAA infusions, without further episodes.", "Patient 2 was similarly premedicated with oral diphenhydramine just prior to all subsequent infusions, without further episodes.", "Multiple hematological parameters, liver functions, renal functions, and urinalyses have all been in the normal range throughout the therapy period in all treated patients.", "Anti-rhGAA antibodies of IgG class were detected in patients 1 and 2 as early as 3 weeks after the initiation of the enzyme therapy (FIGS.", "1A-1C).", "Anti-rhGAA antibody titers increased to 1:1600 by week 16 in patient 1 (FIG.", "1A) and 1:6400-1:12,800 between weeks 11-19 in patient 2 (FIG.", "1B).", "As anti-rhGAA antibody titers increased, we noted that clinical improvements (noted early during therapy—see below) were no longer advancing.", "Neither untoward effects nor anti-rhGAA antibodies have been detected in patient 3 (FIG.", "1C).", "Cardiac status: Prior to the initiation of the enzyme therapy, patients 1 and 2 had severe hypertrophic cardiomyopathy associated with an increased left ventricular (LV) mass, concentric thickening of the ventricular wall and a decrease in size of the ventricular cavity (FIG.", "2B, the cavity in patient 2 was almost obliterated at the end of systole).", "All of these features are typically seen in the untreated patient with the infantile form of Pompe disease.", "Additionally patient 2 was noted to have an increased LV ejection fraction (shortening fraction, 84%) reflective of a hyperdynamic shortening.", "None of the patients, however, had any evidence of obstruction of the ventricular outflow tract.", "The longitudinal echocardiography data assessed in the patients during the first 3 months of rhGAA therapy are shown in FIG.", "2A-2C.", "During the treatment period, in both patients 1 and 2, the LV end-diastolic and end-systolic volumes (2-D measurements) progressively increased, and up to almost 2-3 fold by the end of 3 months of therapy as compared to those measured during the pre-treatment phase (FIG.", "2A and 2B, respectively).", "Similar increases were noted by M-mode analysis (data not show).", "The two-dimensional LV mass measurements (FIG.", "2D-2F) initially increased as the LV volumes increased, but then steadily decreased during therapy, to a value that was less than the pre-treatment LV mass (reduced to 60-70% of the baseline pretreatment levels).", "The initial increase in mass was most likely due to an increase in the LV volume, without any changes in the LV wall thickness.", "These overall improvements in cardiac parameters, were sustained through the latest follow-up evaluation, although patient 1 required an intensive daily enzyme infusion for 10 days when LV mass was further increased and cardiac function compromised at the time of viral pneumonia.", "Otherwise the ventricular function in both patients had been normal and remained normal at the latest follow-up.", "Thus, the progressive cardiac morbidity normally noted in untreated infantile Pompe disease was clearly averted.", "Patient 3 had a Lv mass of 64 g/β2 (upper normal limits 65) but otherwise of normal baseline cardiac evaluation at the initiation of therapy, and has continued to be normal (with LV mass now of 33 g/β2) since 7 months post-therapy.", "Pulmonary function: In the first 2 months of therapy, improvement of pulmonary function was evident by increases in crying vital capacity (improvements of greater than 28% and 70%, in patients 1 and 2, respectively) over baseline capacities, and normalization of O2 desaturation during crying (O2 saturation of 70% in patient 1 and 81% in patient 2 during maximal crying).", "Decreased respiratory muscle strength was also evidenced in patient 1 before the therapy by a negative inspiratory force maneuver (NIFM) of −45 cm H2O.", "With treatment, the NIFM increased to −55 cm H2O.", "The initial improvements noted in the pulmonary functions of both patients, however, plateaued over the next 2-3 months and declined subsequently, concomitant with the rising anti-rhGAA antibodies.", "Both patients have subsequently become ventilator dependent after episodes of viral pneumonia precipitated respiratory insufficiency.", "Patient 3 had a normal pulmonary function at initiation of therapy and has continued to demonstrate normal pulmonary function testing at the latest follow-up.", "Neurodevelopment and motor assessment: Alberta Infant Motor Scale (AIMS) was used to evaluate the motor development in these infants.", "AIMS scores for all 3 patients started below the 5th percentile for age (FIG.", "1A-1C).", "Patient 1 remained below the 5th percentile but showed increases within that range before beginning to decline at week 13 of the therapy (FIG.", "1A).", "Patient 2 rose to the 25th percentile by week 5, dropped back to remain below the 5th percentile after week 7 despite increasing skills, then showed a rapid decline and loss of skills between weeks 13 and 17 (FIG.", "1B).", "The onset of clinical declines, again was concomitant with the rising anti-rhGAA antibodies (FIG.", "1A, 1B).", "Concurrently administered neurologic and Denver Developmental evaluations showed in patient 1, normal personal-social, language, and fine motor developmental domains with ongoing but improving gross motor delay until week 10 when a plateau and subsequent regression became apparent.", "Importantly, gross motor skills had shown significant progress until week 10 but never reached normal.", "Patient 2 showed mild developmental delay in the gross motor sphere only with attainment of normal developmental skills in the fine motor, personal-social, and language domains until weeks 14-16 when regression occurred.", "Currently, both patients have normal personal-social development for age but delay in all other domains.", "Patient 3 showed a steady increase of AIMS score, rising over the 10th percentile by week 11 of the therapy and rising above the 25th percentile by week 20 (FIG.", "1C), and 90th percentile at latest follow-up.", "At age 9 months, he maintained independent sitting, belly crawled reciprocally for mobility, and maintained standing with hands held.", "Remarkably, he has been walking independently since 12 months of age and has been able to move between squatting and standing without hand use since 14 months of age.", "He currently also has normal for age neurologic and Denver development evaluations in all domains.", "Muscle GAA activity and glycogen content: Muscle biopsies were performed at baseline 1 week prior to the start of the rhGAA therapy except in patient 1 who had a biopsy done at the time of diagnosis which was 2 months prior to initiation of rhGAA therapy.", "After 4 months of rhGAA therapy, muscle biopsies were obtained from the contra-lateral quadriceps 3 days after the enzyme infusion (trough level).", "With rhGAA treatment GAA activity increased 2-3 fold over baseline pre-treatment levels in both patients 1 and 2, and 18 fold in patient 3 (Table 3).", "TABLE 3 Muscle Acid α-glucosidase Activity and Glycogen Content in Infantile Pompe Disease Patients Treated with rhGAA GAA Activity Glycogen Content nmole/hr/mg Protein % Wet Weight Patient 1 Pre-therapy 0.41 5.90% Post-therapy 0.95 7.50% Patient 2 Pre-therapy 0.67 5.68% Post-therapy 1.97 4.43% Patient 3 Pre-therapy 0.1 5.13% Post-therapy 1.84 1.43% Control 23.92 +/− 8.63 0.94 +/− 0.55% (upper normal limit; 1.5%) The absolute level of GAA activity approached 8% of the GAA activity seen in normal muscles.", "There were no appreciable changes in the muscle glycogen content in patients 1 and 2, but glycogen levels were reduced to within normal range in patient 3.Histology.", "The pre-treatment biopsies of all the patients showed marked vacuolization of the muscle fibers in the frozen sections.", "Evaluation of the semithin sections demonstrated the fibers to be expanded by glycogen with the formation of glycogen lakes.", "In some fibers faint outlines of residual membranes could be discerned.", "Electron microscopy confirmed the presence of glycogen both in expanded lysosomes and lying free in the cytoplasm.", "The biopsy from patient 3 had more glycogen remaining within lysosomes than did the other two patients (data not shown).", "The 4-month post-treatment biopsies of patients 1 and 2 were similar to the pre-treatment biopsies in terms of glycogen accumulation.", "The post-treatment biopsy of patient 3, however, had a marked decrease in visible glycogen and essentially normal histology in most of the muscle fibers.", "Electron microscopy showed many remaining distended lysosomes were depleted of glycogen.", "Some glycogen lakes and glycogen-rich lysosomes remained.", "Western Blot Analysis To investigate why anti-rhGAA antibodies developed in patients 1 and 2, but not 3, we performed a Western blot analysis specific for detection of expressed (but nonfunctional) GAA protein in fibroblasts derived from each of the patients.", "No GAA protein was detected in the fibroblasts of patients 1 and 2, whereas a readily detectable precursor form of G AA protein (110 kD) was found in patient 3.These patterns were previously seen in other patients with infantile GSD-II (Van der Ploeg, A. T. et al., Am.", "J. Hum.", "Genet.", "44:787-793 (1989)).", "Normal fibroblasts as expected have GAA protein predominantly of 95 kD and 76 kD.", "FURTHER STUDIES Three more patients have been enrolled in an additional study.", "All three are CRIM positive.", "After treatment (10 mg/kilogram body weight, weekly intravenous infusions of rhGAA) for 3-6 weeks, improvement of heart function, muscle strength, and motor development have been seen.", "The teachings of all publications cited herein are incorporated herein by reference in their entirety.", "While this invention has been particularly shown and described with reference to preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims." ] ]
Patent_15876086
[ [ "CASHBACK MANAGEMENT SYSTEM", "The disclosed technology provides a cashback management system which allows extra accumulation of cashback based on a consumer ranking in a cashback.", "In one aspect, the cashback management system is provided to comprise: a ranking setting module for setting a consumer ranking in the order of an amount of cashback accumulated in a consumer account and adjusting the ranking according to a change in the amount of the accumulated cashback; and an accumulation module for accumulating a part of cashback generated from a purchase made by a particular consumer to one or more other consumers each with a ranking higher than a ranking of the particular consumer." ], [ "1.A cashback management system allowing extra accumulation of cashback based on a cashback ranking, the cashback management system comprising: a ranking setting module that sets a ranking of a consumer in the order of an amount of cashback accumulated in a consumer account and adjusts the ranking according to a change in the amount of the accumulated cashback; and an accumulation module that accumulates a part of cashback generated from a purchase made by a particular consumer to one or more other consumers each with a ranking higher than a ranking of the particular consumer, wherein the accumulation module is operable to accumulate the part of the cashback money to one or more other consumers each with a ranking higher than the ranking of the particular consumer by steps including: accumulating to a first ranked consumer whose ranking is in the first place a first amount that is a predetermined ratio of the cashback generated by the purchase of the particular consumer; and accumulating to a second ranked consumer whose ranking is in the second place a second amount that is the predetermined ratio of an amount that is obtained by subtracting the first amount from the cashback generated by the purchase of the particular consumer, wherein the accumulation module applies the steps sequentially to all of other consumers with rankings higher than the ranking of the particular consumer and accumulates to the particular consumer a remaining amount of the cashback after the cashback is allocated to all of other consumers with rankings higher than the ranking of the particular consumer, and wherein the cashback accumulated in the consumer account further comprises an amount of money deposited by the consumer.", "2.The cashback money management system according to claim 1, wherein the ranking setting module sets the ranking of the consumer in the order of a sum of the cashback accumulated in the consumer account and purchase money paid from the consumer account.", "3.The cashback money management system according to claim 2, wherein the purchase money comprises a purchase amount generated by purchase of the consumer and a prepayment amount.", "4.The cashback money management system according to claim 1, wherein the ranking setting module adjusts the ranking in real time according to the amount of the accumulated cashback which is changed according to the accumulation of the cashback by the accumulation module.", "5.The cashback money management system according to claim 1, wherein the accumulation module deducts a cashback from the consumer account upon an use of the cashback by the consumer." ], [ "<SOH> BACKGROUND <EOH>A cashback is a type of virtual money or cyber money that is awarded to consumers on-line or off-line by companies and the like in order to induce more activities by consumers.", "The cashback can be used to motivate the consumers to visit a store by allowing the consumer to use of the cashback.", "A process for providing cashback generally allows a certain percentage of the purchase price to be accumulated in an account of a consumer who made a corresponding purchase, and allows the consumer to use the accumulated cashback as part of the payment for future purchases or to exchange the accumulated cashback for coupons or specific products." ], [ "<SOH> SUMMARY <EOH>Various implementations are provided to introduce a unique manner of managing cashback which allows consumers to accumulate cashback faster and more effectively.", "Some implementations of the disclosed technology set a ranking of a consumer according to the amount of cashback accumulated in a consumer account.", "Therefore, the more the consumer spends, the higher the ranking of the consumer becomes.", "Some implementations of the disclosed technology allow to accumulate a predetermined ratio of the cashback generated by activities of a particular consumer not only in the account of that particular consumer but also in the accounts of another consumer whose cashback ranking is higher than that particular consumer.", "Therefore, the higher the ranking of the consumer has, the faster the accumulation of the cashback is made by the activities of other consumers, whereby a cashback management system allows extra accumulation of cashback according to an accumulated cashback ranking.", "Thus, the consumer can accumulate the cashback more quickly and invest or use the accumulated cashback, which improves the satisfaction of the consumer.", "Some implementation of the disclosed technology provides a cashback management system allowing extra accumulation of cashback according to an accumulated cashback ranking.", "In some implementations, the cashback ranking is determined based on the sum of the amount of money deposited by the consumer and the amount of the cashback generated, whereby the consumer can increase his or her ranking by depositing the money by a suitable method and thus increase the accumulated cashback faster.", "In one aspect, a cashback management system is provided to comprise: a ranking setting module for setting a ranking of a consumer based on an amount of cashback accumulated in a consumer account and adjusting the ranking according to a change in the amount of the accumulated cashback; and an accumulation module for accumulating a predetermined ratio of cashback generated by activities, such as consumption or purchase, of the consumer, to one or more other consumers each with a rankings higher than a ranking of the consumer.", "In another aspect, a cashback management system based on a consumer ranking associated with an accumulated cashback by a consumer is provided.", "The cashback management system comprises: a ranking setting module that sets a ranking of a consumer based on an amount of cashback accumulated in a consumer account and adjusts the ranking according to a change in the amount of the accumulated cashback; and an accumulation module that transfers a part of cashback generated from purchases made by a particular consumer to one or more other consumers each with a ranking higher than a ranking of the particular consumer to allow the one or other consumers with a higher ranking to accumulate additional cashback based on ranking, wherein the accumulation module is operable to further: transfer to a first ranked consumer whose ranking is in the first place among ranked consumers, a first additional amount of cashback which is computed from a predetermined ratio of the cashback generated by the particular consumer; and transfer to a second ranked consumer whose ranking is in the second place among ranked consumers, a second additional amount of cashback which is an amount computed from the predetermined ratio of a remaining cashback that is obtained by subtracting the first additional amount of cashback from the cashback generated by the particular consumer, wherein the accumulation module applies the steps sequentially to all of other consumers with rankings higher than that of the particular consumer, and wherein the cashback accumulated in the consumer account further comprises an amount of money deposited by the consumer.", "In some implementations, the ranking setting module sets the ranking of the consumer in the order of an amount of the cashback accumulated in the consumer account.", "In some implementations, the ranking setting module sets the ranking of the consumer in the order of the sum of the cashback accumulated in the consumer account and purchase money paid from the consumer account.", "In some implementations, the purchase money comprises a purchase amount generated by the consumption of the consumer and a prepayment amount.", "The disclosed technology provides a cashback management system where the cashback for a particular user can be accumulated based on activities of other users than the particular user as well as activities of the particular user.", "The cashback accumulated in an account of a particular user comprises the amount of cashback which is generated by the consumption of the particular consumer, and the amount of cashback which is generated by consumption of another consumer.", "In some implementations, the cashback accumulated in the account of a consumer further comprises the amount of money deposited by the consumer.", "According to an embodiment, the ranking setting module adjusts the ranking in real time according to the amount of the accumulated cashback which is changed according to the cashback accumulation by the accumulation module.", "According to an embodiment, if a consumer whose ranking is in the Nth place takes an action to create a cashback, the accumulation module accumulates a predetermined ratio of the cashback generated by the consumption of the Nth ranked consumer in accounts of other consumers whose rankings are higher than that of the Nth consumer.", "Thus, the accumulation module accumulates a portion of the cashback to the first ranked consumer to the (N-1)th ranked consumer, wherein the accumulation module accumulates the predetermined ratio of the generated cashback in the first ranked consumer, and accumulates the predetermined ratio of the cashback which remains after the accumulation for the first ranked consumer to another consumer whose ranking is for example, in the (n-1)th (n is an integer equal to or greater than 2 and equal to or less than N-1).", "After the accumulation for other consumers, the accumulation module accumulates the remaining cashback for the Nth ranked consumer.", "According to an embodiment, the accumulation module deducts a cashback from the consumer account upon a use of the cashback by the consumer.", "Some implementations of the disclosed technology provide a cashback management system which determines or sets a ranking of a consumer according to a total amount of cashback accumulated in a consumer account.", "Therefore, the more the consumer spends, the higher the ranking of the consumer becomes.", "Since the exemplary cashback management system allows to accumulate a predetermined ratio of the cashback generated by activities of the consumer in another consumer's account in a higher ranking, if the ranking of the consumer is higher, it is possible to accumulate cashback faster by using activities of others who have lower rankings.", "Accordingly, the cashback management system allows the consumer to accumulate the cashback quickly and use or invest the accumulated cashback, which improves the satisfaction of the consumer.", "According to the implementations of the disclosed technology, a mechanism is provided for a consumer to increase his/her ranking since the ranking is decided in consideration of money paid by a consumer (including payments made for not only current purchases but also future activities) and cashback generated by the consumer's activities.", "Accordingly, the consumer can increase his or her ranking by depositing the money by a suitable method and thus make the accumulation of cashback faster." ], [ "CROSS-REFERENCE TO RELATED APPLICATION(S) This application claims priority to and the benefit of PCT Application No.", "PCT/KR2016/007805 filed on Jul.", "18, 2016 which claims priority to Korean Patent Application No.", "10-2015-0103787 filed on Jul.", "22, 2015.The above applications are all hereby incorporated by reference for all purposes as if fully set forth herein.", "TECHNICAL FIELD Some implementations of the disclosed technology relate to a cashback management system.", "For example, some implementations of the disclosed technology allow an extra accumulation of cashback.", "BACKGROUND A cashback is a type of virtual money or cyber money that is awarded to consumers on-line or off-line by companies and the like in order to induce more activities by consumers.", "The cashback can be used to motivate the consumers to visit a store by allowing the consumer to use of the cashback.", "A process for providing cashback generally allows a certain percentage of the purchase price to be accumulated in an account of a consumer who made a corresponding purchase, and allows the consumer to use the accumulated cashback as part of the payment for future purchases or to exchange the accumulated cashback for coupons or specific products.", "SUMMARY Various implementations are provided to introduce a unique manner of managing cashback which allows consumers to accumulate cashback faster and more effectively.", "Some implementations of the disclosed technology set a ranking of a consumer according to the amount of cashback accumulated in a consumer account.", "Therefore, the more the consumer spends, the higher the ranking of the consumer becomes.", "Some implementations of the disclosed technology allow to accumulate a predetermined ratio of the cashback generated by activities of a particular consumer not only in the account of that particular consumer but also in the accounts of another consumer whose cashback ranking is higher than that particular consumer.", "Therefore, the higher the ranking of the consumer has, the faster the accumulation of the cashback is made by the activities of other consumers, whereby a cashback management system allows extra accumulation of cashback according to an accumulated cashback ranking.", "Thus, the consumer can accumulate the cashback more quickly and invest or use the accumulated cashback, which improves the satisfaction of the consumer.", "Some implementation of the disclosed technology provides a cashback management system allowing extra accumulation of cashback according to an accumulated cashback ranking.", "In some implementations, the cashback ranking is determined based on the sum of the amount of money deposited by the consumer and the amount of the cashback generated, whereby the consumer can increase his or her ranking by depositing the money by a suitable method and thus increase the accumulated cashback faster.", "In one aspect, a cashback management system is provided to comprise: a ranking setting module for setting a ranking of a consumer based on an amount of cashback accumulated in a consumer account and adjusting the ranking according to a change in the amount of the accumulated cashback; and an accumulation module for accumulating a predetermined ratio of cashback generated by activities, such as consumption or purchase, of the consumer, to one or more other consumers each with a rankings higher than a ranking of the consumer.", "In another aspect, a cashback management system based on a consumer ranking associated with an accumulated cashback by a consumer is provided.", "The cashback management system comprises: a ranking setting module that sets a ranking of a consumer based on an amount of cashback accumulated in a consumer account and adjusts the ranking according to a change in the amount of the accumulated cashback; and an accumulation module that transfers a part of cashback generated from purchases made by a particular consumer to one or more other consumers each with a ranking higher than a ranking of the particular consumer to allow the one or other consumers with a higher ranking to accumulate additional cashback based on ranking, wherein the accumulation module is operable to further: transfer to a first ranked consumer whose ranking is in the first place among ranked consumers, a first additional amount of cashback which is computed from a predetermined ratio of the cashback generated by the particular consumer; and transfer to a second ranked consumer whose ranking is in the second place among ranked consumers, a second additional amount of cashback which is an amount computed from the predetermined ratio of a remaining cashback that is obtained by subtracting the first additional amount of cashback from the cashback generated by the particular consumer, wherein the accumulation module applies the steps sequentially to all of other consumers with rankings higher than that of the particular consumer, and wherein the cashback accumulated in the consumer account further comprises an amount of money deposited by the consumer.", "In some implementations, the ranking setting module sets the ranking of the consumer in the order of an amount of the cashback accumulated in the consumer account.", "In some implementations, the ranking setting module sets the ranking of the consumer in the order of the sum of the cashback accumulated in the consumer account and purchase money paid from the consumer account.", "In some implementations, the purchase money comprises a purchase amount generated by the consumption of the consumer and a prepayment amount.", "The disclosed technology provides a cashback management system where the cashback for a particular user can be accumulated based on activities of other users than the particular user as well as activities of the particular user.", "The cashback accumulated in an account of a particular user comprises the amount of cashback which is generated by the consumption of the particular consumer, and the amount of cashback which is generated by consumption of another consumer.", "In some implementations, the cashback accumulated in the account of a consumer further comprises the amount of money deposited by the consumer.", "According to an embodiment, the ranking setting module adjusts the ranking in real time according to the amount of the accumulated cashback which is changed according to the cashback accumulation by the accumulation module.", "According to an embodiment, if a consumer whose ranking is in the Nth place takes an action to create a cashback, the accumulation module accumulates a predetermined ratio of the cashback generated by the consumption of the Nth ranked consumer in accounts of other consumers whose rankings are higher than that of the Nth consumer.", "Thus, the accumulation module accumulates a portion of the cashback to the first ranked consumer to the (N-1)th ranked consumer, wherein the accumulation module accumulates the predetermined ratio of the generated cashback in the first ranked consumer, and accumulates the predetermined ratio of the cashback which remains after the accumulation for the first ranked consumer to another consumer whose ranking is for example, in the (n-1)th (n is an integer equal to or greater than 2 and equal to or less than N-1).", "After the accumulation for other consumers, the accumulation module accumulates the remaining cashback for the Nth ranked consumer.", "According to an embodiment, the accumulation module deducts a cashback from the consumer account upon a use of the cashback by the consumer.", "Some implementations of the disclosed technology provide a cashback management system which determines or sets a ranking of a consumer according to a total amount of cashback accumulated in a consumer account.", "Therefore, the more the consumer spends, the higher the ranking of the consumer becomes.", "Since the exemplary cashback management system allows to accumulate a predetermined ratio of the cashback generated by activities of the consumer in another consumer's account in a higher ranking, if the ranking of the consumer is higher, it is possible to accumulate cashback faster by using activities of others who have lower rankings.", "Accordingly, the cashback management system allows the consumer to accumulate the cashback quickly and use or invest the accumulated cashback, which improves the satisfaction of the consumer.", "According to the implementations of the disclosed technology, a mechanism is provided for a consumer to increase his/her ranking since the ranking is decided in consideration of money paid by a consumer (including payments made for not only current purchases but also future activities) and cashback generated by the consumer's activities.", "Accordingly, the consumer can increase his or her ranking by depositing the money by a suitable method and thus make the accumulation of cashback faster.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is an exemplary view showing a configuration of a cashback management system according to an implementation of the disclosed technology.", "FIGS.", "2 to 5 are exemplary views showing examples of cashback accumulations and ranking changes in a cashback management system according to an implementation of the disclosed technology.", "DETAILED DESCRIPTION Techniques disclosed in this patent document provide a cashback management system.", "The cashback may be referred to as different names, for example, reward points, mileages, coupons, credits, gifts, incentives, etc.", "The disclosed technology would provide a system and a method for managing those offerings which are given to consumers in connection with activities occurred in an on-line/off-line market or an on-line platform.", "The disclosed technology allows a consumer to accumulate cashback in a faster and more effective manner to improve consumer experience using cashback.", "As cashback marketing can increase the sales revenue and attract customers, there has been an attempt to diversify ways to provide cashback, for example, by setting a high rate of cashback temporarily during an event or providing a certain amount of money as cashback when purchasing a specific product.", "However, the conventional cashback managements did not make consumers satisfied or attracted to the cashback because it is difficult to accumulate the cashback and thus, there is no investment value in the cashback itself.", "Accordingly, it is not that uncommon that the amount of the cashback is not even used and disappears.", "The examples of the conventional cashback managements are provided: Korean Patent Laid-open Publication No.", "10-2013-0062387 (Title: Reserve point management system and method for providing additional reserve point to user selecting affiliation; published on Jun.", "13, 2013) and Korean Patent Laid-open Publication No.", "10-2012-0048871 (Title of invention: Reserve point management system and method for determining reserve point with regard to transaction between user and advertiser using rate of reserve point determined by advertiser; published on May 16, 2012) are disclosed.", "Some implementations of the disclosed technology provide a cashback management system/method which differs from the conventional cashback management systems as discussed below and can solve the problems in the conventional cashback management systems.", "Hereinafter, various implementations of the disclosed technology will be described in detail with reference to the accompanying drawings so that those skilled in the art can easily carry out the present invention.", "In the following detailed description of the embodiments of the disclosed technology, a detailed description of known functions or configurations will be omitted.", "The same reference numerals are used throughout the drawings for portions having similar functions and actions.", "In addition, in the entire specification, when a part is referred to as being “connected” with another part, it is not only a case where it is directly connected, but also a case where it is indirectly connected with another element therebetween.", "Also, “comprising” and “including” mean that other components may be included, rather than excluding other components, unless specifically stated otherwise.", "FIG.", "1 is an exemplary view showing a configuration of a cashback management system 10 allowing extra accumulation of cashback according to an accumulated cashback ranking, according to an embodiment of the disclosed technology.", "As shown in FIG.", "1, the exemplary cashback management system 10 may comprise a ranking setting module 100 and an accumulation module 200.The term “module” as used herein may include software, hardware, or a combination thereof depending on the context in which the term is used.", "For example, the software may be machine code, firmware, embedded code, application software, or a combination thereof.", "Also, for example, the hardware may be a circuit, a processor, a computer, an integrated circuit, integrated circuit cores, or a combination thereof.", "The ranking setting module 100 and the accumulation module 200 may be implemented in one computer in some applications, or may be distributed in more than one computers or servers linked to a communication network to allow communications between the ranking setting module 100 and the accumulation module 200.According to some implementations, the ranking setting module 100 may determine or set a ranking of a consumer according to the amount of cashback accumulated in a consumer account associated with the consumer.", "The accumulation module 200 may accumulate in the consumer account the cashback generated from on-line/off-line activities, for example, purchasing products, by the consumer.", "Therefore, the more the consumer actively makes purchases or spends money, the higher the ranking of the consumer can be placed at.", "As explained above, the cashback is accumulated in the account of the consumer who made purchase or spends money.", "In some implementations, a predetermined ratio of the cashback generated from on-line/off-line activities of the consumer is accumulated in not only the account of the consumer but also the account of another consumer whose ranking is placed at higher than that of the consumer.", "Thus, consumers whose rankings are relatively higher can get “extra” accumulation of the cashback from the activities of others whose rankings are relative lower.", "Therefore, if the consumer's raking is higher, the consumer can accumulate the cashback faster since the cashback can be accumulated from the activities of other consumers who are placed in a lower ranking.", "Thus, the consumer can accumulate the cashback quickly and invest the accumulated cashback as desired.", "Hereinafter, each element of the cashback management system 10 allowing extra accumulation of the cashback according to the accumulated cashback ranking, according to an implementation of the disclosed technology will be described in detail.", "The ranking setting module 100 may be structured to determine or set a ranking of a consumer based on cashback accumulated in the consumer account and/or activities of the consumer.", "In some implementations, the ranking setting module 100 may determine or set the ranking of the consumer according to the amount of the cashback accumulated in the consumer account and adjust the ranking according to change in the amount of the accumulated cashback.", "The ranking setting module 100 may determine or set the ranking of the consumer in the order of the amount of the cashback accumulated in the consumer account.", "The cashback accumulated in the consumer account may comprise the amount of the cashback which is generated by activities of the consumer, and the amount of the cashback which is generated by activities of other consumers.", "The activities of the consumer to generate the cashback include making payments such as purchasing of a product.", "The cashback accumulated in the consumer account may further comprise the amount of the money deposited by the consumer.", "Thus, the consumer can add his or her money to the accumulated cashback by making deposits, for example, using credit cards, bank transfer, gift cards, points, coupons, etc.", "The money deposited in this way may be added to the cashback which have been earned from the activities by the consumer and managed as the accumulated cashback in the account of the consumer.", "Therefore, the consumer who wants to increase the ranking quickly can increase the ranking by depositing the money in the consumer account and increasing the amount of the accumulated cashback by the deposited money.", "In some implementations, the ranking of the consumer may be determined or set based on both the cashback accumulated in the consumer account and the activities of the consumer.", "For example, the ranking setting module 100 determines or sets the ranking in the order of the sum of the cashback accumulated in the consumer account and the purchase money paid from the consumer account.", "In this case, the degree of contribution of the consumer to the purchase money by activities, for example, purchases, can be reflected in the ranking.", "The degree of contribution may be different in various products depending on the types of the products.", "For example, there may be a product with a relatively small accumulation amount relative to the price of the product and there may be another product with a relatively big accumulation amount relative to the price of the product.", "The disclosed technology can provide the cashback money management system to minimize or avoid the feeling that the consumer is disadvantaged through the purchase of a product, and allow the consumer to be ranked more fairly.", "In some implementations, the purchase money may comprise a purchase amount generated by activities of the consumer and a prepayment amount.", "The consumer may make a payment in advance for the amount to be used without purchasing the product, and by including this prepayment amount in the purchase money, the actual amount spent by the consumer can be accurately reflected in the ranking.", "Furthermore, the purchase money may be considered only for a predetermined period of time, such as 6 months, 1 year, 3 years, etc., which can lead the consumer to continue to create activities by, for example, spending money and provide a way for new consumers to be placed at a high ranking.", "The ranking setting module 100 may adjust the ranking in real time according to the amount of the accumulated cashback which are changed according to the cashback accumulation of the accumulation module 200, which will be described in detail below.", "The amount of the accumulated cashback of each consumer may be changed according to the accumulation result of the accumulation module 200, and the ranking setting module 100 may reflect the change in the amount of the accumulated cashback in the ranking in real time.", "The accumulation module 200 may accumulate a predetermined ratio of the cashback generated by activities of the consumer to a higher ranked consumer.", "When the cashback is generated by activities of the consumer having a specific ranking set by the ranking setting module 100, a part of the generated cashback may be accumulated as well in the account of a consumer having a ranking higher than the specific ranking.", "Therefore, the consumer with a higher ranking can automatically increase the accumulated cashback due to the activities of others, even if he/she is not involved with any activities.", "In some implementations, the accumulation module 200 may accumulate a predetermined ratio of the cashback generated by activities of a Nth ranked consumer in the accounts of consumers who have ranked the first to (N-1)th.", "In accumulating a predetermined ratio of the cashback generated by a Nth ranked consumer, the accumulation module 200 may be structured to provide the cashback to all of the consumers who have ranked the first to (N-1)th.", "In some implementations, the accumulation module 200 may be structured to provide the cashback to only a part of the consumers among those who have ranked the first to (N-1)th.", "Thus, the accumulation module 200 may first select all or a part of the consumers who have ranked the first to (N-1)th.", "In some implementations, the accumulation module 200 may accumulate, in the accounts of the selected consumers among those in the first to (N-1)th places, different amounts of the generated cashback.", "For example, the accumulation module 200 may accumulate the predetermined ratio of the generated cashback in the first ranked consumer.", "Then, the accumulation module 200 may accumulate the predetermined ratio of the remaining cashback which remains after the accumulation for the first ranked consumer in the account of the second ranked consumer.", "The accumulation module 200 may repeat the accumulation in this manner for the remaining selected consumers.", "After making accumulations in the accounts of the selected consumers among those in the first to (N-1)th places, the accumulation module 200 may accumulate the remaining cashback in the account of the Nth ranked consumer.", "For example, if cashback is generated by activities of the 10th ranked consumer, a predetermined ratio of the cashback is sequentially provided to the first ranked consumer to the 9th ranked consumer, and the remaining cashback is accumulated in the 10th ranked consumer.", "Among the higher ranked consumers, the cashback provided to the first consumer is the greatest, the amount of the provided cashback is gradually reduced, and the cashback provided to the 9th ranked consumer is the smallest.", "The cashback generated from the activities of the 10th ranked consumer is not provided to the 11th ranked consumer and the consumers having rankings lower than the 11th.", "The ranking setting module 100 may adjust the ranking in real time by reflecting the accumulation result of the accumulation module 200 as described above.", "Therefore, the ranking may be changed each time at the generation and accumulation of the cashback.", "FIGS.", "2 to 5 are exemplary views showing examples of cashback accumulations and ranking changes in the cashback management system 10 allowing extra accumulation of cashback according to the accumulated cashback ranking.", "Hereinafter, with reference to FIGS.", "2 to 5, a description of a ranking setting process and a cashback accumulation process of the cashback management system 10 will be given in detail.", "First, as shown in FIG.", "2, if the purchase money and the accumulated cashback of the consumers A, B, and C are all 0 (zero), the rankings of the consumers A, B, and C are the same.", "In this situation, if the consumer A purchases a product which is priced with a price of 8,000 Korean won (KRW) and is listed as providing a cashback of 3,000 Korean won in response to the purchase, the cashback of 3,000 Korean won are all accumulated in the consumer A since there is no higher ranked consumer than the consumer A.", "After the accumulation result is reflected, the ranking setting module 100 sets the consumer A (accumulated cashback of 3,000 Korean won) as the first place and the consumers B and C (accumulated cashback of 0 Korean won) as the second place, and adjusts the ranking as shown in FIG.", "3.If the second ranked consumer B purchases a product with a price of 20,000 Korean won and the purchase of the product provides a cashback of 8,000 Korean won, a part of the cashback of 8,000 Korean won is accumulated to the higher ranked consumer A than the consumer B as well as the second ranked consumer B.", "For example, if the predetermined ratio is 10%, the amount of 800 Korean won, which is 10% of the cashback of 8,000 Korean won, is added to the account of the higher ranked consumer A than the consumer B, and the amount of the accumulated cashback of the consumer A becomes 3,800 Korean won, and the remaining cashback of 7,200 Korean won is accumulated to the account of the consumer B.", "As a result, since the amount of the accumulated cashback of the consumer B becomes greater than that of the consumer A, the ranking setting module 100 sets the ranking of the consumer B (accumulated cashback of 7,200 Korean won) as the first, the ranking of the consumer A (accumulated cashback of 3,800 Korean won) as the second, and the ranking of the consumer C (accumulated cashback of 0 Korean won) as the third.", "If the third ranked consumer C purchases a product with a price of 10,000 Korean won and the purchase provides a cashback of 5,000 Korean won, the amount of 500 Korean won, which is 10% of the cashback of 5,000 Korean won, is first added to the account of the first ranked consumer B between the higher ranked consumers A and B than the consumer C, and the amount of the accumulated cashback of the consumer B becomes 7,700 Korean won.", "The amount of 450 Korean won, which is 10% of the remaining cashback of 4,500 Korean won, is added to the account of the second ranked consumer A, and the amount of the accumulated cashback of the consumer A becomes 4,250 Korean won.", "After the cashback accumulation for the consumers A and B, the remaining cashback of 4,050 Korean won is accumulated to the account of the consumer C. If the ranking setting module 100 determines the ranking based on the amount of the accumulated cashback only, the consumer B will be ranked first, the consumer A will be ranked second, and the consumer C will be ranked third, as shown in FIG.", "5.If the ranking setting module 100 determines the ranking based on the sum of the purchase money and the accumulated cashback, the consumer B will be ranked first, the consumer C will be ranked second, and the consumer A will be ranked third.", "In the latter case, the activity by the consumer C can change the rankings of the consumers A and C. If the consumer uses the accumulated cashback, the accumulation module 200 deducts the used cashback from the consumer account.", "Thus, the accumulated cashback can be used as cash when purchasing a product.", "If the consumer makes a settlement using the accumulated cashback, the accumulation module 200 deducts the accumulated cashback as much as the used amount.", "Since the amount of the accumulated cashback of the consumer is reduced, the ranking setting module 100 adjusts the ranking in real time reflecting the subtracted accumulated cashback.", "While this patent document contains many specifics, these should not be construed as limitations on the scope of any invention or of what may be claimed, but rather as descriptions of features that may be specific to particular embodiments of particular inventions.", "Certain features that are described in this patent document in the context of separate embodiments can also be implemented in combination in a single embodiment.", "Conversely, various features that are described in the context of a single embodiment can also be implemented in multiple embodiments separately or in any suitable subcombination.", "Moreover, although features may be described above as acting in certain combinations and even initially claimed as such, one or more features from a claimed combination can in some cases be excised from the combination, and the claimed combination may be directed to a subcombination or variation of a subcombination.", "Similarly, while operations are depicted in the drawings in a particular order, this should not be understood as requiring that such operations be performed in the particular order shown or in sequential order, or that all illustrated operations be performed, to achieve described results.", "Moreover, the separation of various system components in the embodiments described in this patent document should not be understood as requiring such separation in all embodiments.", "Only a few implementations and examples are described.", "Other implementations, enhancements and variations can be made based on what is described and illustrated in this patent document.", "From the foregoing, it will be appreciated that specific embodiments of the invention have been described herein for purposes of illustration, but that various modifications may be made without deviating from the scope of the invention.", "Accordingly, the invention is not limited except as by the appended claims." ] ]
Patent_15876089
[ [ "SYSTEMS AND METHODS FOR DISPLAYING VEHICLE INFORMATION FOR ON-DEMAND SERVICES", "The present disclosure relates to systems and methods for displaying vehicle information for an on-demand service.", "The method may include sending a request for on-demand service to a server.", "The method may further include obtaining information of a vehicle related to the request for on-demand service.", "The information of the vehicle may include color information of the vehicle.", "The method may further include generating, by a processor, a user interface based on the information of the vehicle.", "The user interface may include at least one user interface element corresponding to the color information of the vehicle." ], [ "1.A system, comprising: a bus; at least one storage medium electronically connected to the bus, including a set of instructions for displaying vehicle information for an on-demand service; and logic circuits configured to communicate with the at least one storage media via the bus, wherein when executing the set of instructions, the logic circuits are directed to: send, to a server, electronic signals including a request for on-demand service; obtain electronic signals including information of a vehicle related to the request for on-demand service, the information of the vehicle comprising color information of the vehicle; and generate a user interface based on the information of the vehicle, wherein the user interface comprises at least one user interface element corresponding to the color information of the vehicle.", "2.The system of claim 1, further comprising a display configured to present the user interface.", "3.The system of claim 2, wherein the display is further to: display text information of the vehicle based on the color information of the vehicle, wherein the information of the vehicle further comprises the text information of the vehicle.", "4.The system of claim 2, wherein the display is further to: display logo information of the vehicle in the user interface based on the color information of the vehicle, wherein the information of the vehicle further comprises the logo information of the vehicle.", "5.The system of claim 1, wherein to obtain the color information of the vehicle, the logic circuits are further directed to: obtain electronic signals including descriptive information corresponding to a color of the vehicle; and determine the color information of the vehicle based on the descriptive information.", "6.The system of claim 1, wherein to obtain the electronic signals including color information of the vehicle, the logic circuits are further directed to: obtain electronic signals including image data of the vehicle; and determine the color information of the vehicle based on the image data.", "7.A non-transitory machine-readable storage medium including instructions that, when accessed by logic circuits of an online on-demand service platform from a requester terminal, causes the logic circuits to: receive electronic signals including a request for on-demand service; determine a vehicle in response to the request for on-demand service; obtain electronic signals including information related to the vehicle, the information comprising color information of the vehicle; provide, to at least one requester terminal, electronic signals including the information related to the vehicle for presentation in at least one user interface; and instruct the requester terminal to display at least one user interface element in the user interface based on the color information of the vehicle.", "8.The non-transitory machine-readable storage medium of claim 7, wherein to obtain the color information of the vehicle, the logic circuits are further to: obtain electronic signals including descriptive information corresponding to a color of the vehicle; and determine the color information of the vehicle based on the descriptive information.", "9.The non-transitory machine-readable storage medium of claim 8, wherein to obtain the electronic signals including descriptive information corresponding to the color of the vehicle, the logic circuits are further to: parse the descriptive information corresponding to the color of the vehicle.", "10.The non-transitory machine-readable storage medium of claim 7, wherein to obtain the electronic signals including color information of the vehicle, the logic circuits are further to: obtain electronic signals including image data of the vehicle; and determine the color information of the vehicle based on the image data.", "11.A method configured to display vehicle information for an on-demand service, comprising: sending, to a server, electronic signals including a request for on-demand service; obtaining electronic signals including information of a vehicle related to the request for on-demand service, the information of the vehicle comprising color information of the vehicle; generating, by a processor, a user interface based on the information of the vehicle, wherein the user interface comprises at least one user interface element corresponding to the color information of the vehicle; and displaying the user interface.", "12.The method of claim 11, further comprising: displaying text information of the vehicle in the user interface based on the color information of the vehicle, wherein the information of the vehicle further comprises the text information of the vehicle.", "13.The method of claim 11, further comprising: displaying logo information of the vehicle in the user interface based on the color information of the vehicle, wherein the information of the vehicle further comprises the logo information of the vehicle.", "14.The method of claim 11, wherein obtaining the electronic signals including color information of the vehicle comprises: obtaining electronic signals including descriptive information corresponding to a color of the vehicle; and determining the color information of the vehicle based on the descriptive information.", "15.The method of claim 14, wherein obtaining the electronic signals including descriptive information corresponding to the color of the vehicle comprises: parsing the descriptive information corresponding to the color of the vehicle.", "16.The method of claim 11, wherein obtaining the electronic signals including color information of the vehicle comprises: obtaining image data of the vehicle; and determining the color information of the vehicle based on the image data.", "17-20.", "(canceled) 21.The system of claim 5, wherein to determine the color information of the vehicle based on the descriptive information, the logic circuits are further directed to: parse the descriptive information corresponding to the color of the vehicle.", "22.The system of claim 7, wherein the logic circuits are further to: instruct the requester terminal to display text information of the vehicle based on the color information of the vehicle, wherein the information of the vehicle further comprises the text information of the vehicle.", "23.The system of claim 7, wherein the logic circuits are further to: instruct the requester terminal to display logo information of the vehicle in the user interface based on the color information of the vehicle, wherein the information of the vehicle further comprises the logo information of the vehicle.", "24.The method of claim 1, wherein the user interface element is a vehicle-shaped icon." ], [ "<SOH> BACKGROUND <EOH>On-demand services, such as online ridesharing services and delivery services, have become increasingly popular because of their convenience.", "A service platform that provides such services may need to process a high volume of complex data and conduct a massive amount of computation to automatically process and fulfill user requests.", "To provide scalable and real-time services to millions of users, such a service platform may need to perform the processing and computation using pattern recognition techniques, machine learning techniques, data mining techniques, predictive analytics, user behavior analytics, cloud computing techniques, and other computational techniques." ], [ "<SOH> SUMMARY <EOH>According to an aspect of the present disclosure, a system is provided.", "The system may include at least one storage medium and at least one processor configured to communicate with the at least one storage medium.", "The at least one storage medium may include a set of instructions for displaying vehicle information for an on-demand service.", "When the at least one processor executing the set of instructions, the at least one processor may be directed to perform one or more of the following operations.", "The at least one processor may send a request for on-demand service to a server.", "The at least one processor may obtain information of a vehicle related to the request for on-demand service.", "The information of the vehicle may include color information of the vehicle.", "The at least one processor may generate a user interface based on the information of the vehicle.", "The user interface may include at least one user interface element corresponding to the color information of the vehicle.", "In some embodiments, the system may further include a display configured to present the user interface.", "In some embodiments, the information of the vehicle may further include text information and/or logo information of the vehicle.", "The display may further display text information and/or logo information of the vehicle based on the color information of the vehicle.", "In some embodiments, the at least one processor may be further directed to obtain descriptive information corresponding to a color of the vehicle, and to determine the color information of the vehicle based on the descriptive information.", "In some embodiments, the at least one processor may be further directed to obtain image data of the vehicle, and to determine the color information of the vehicle based on the image data.", "According to another aspect of the present disclosure, a non-transitory machine-readable storage medium may include instructions.", "When the non-transitory machine-readable storage medium accessed by at least one processor of an online on-demand service platform from a requester terminal, the instructions may cause the at least one processor to perform one or more of the following operations.", "The instructions may cause the at least one processor to receive a request for on-demand service.", "The instructions may cause the at least one processor to determine a vehicle related to the request for on-demand service.", "The instructions may cause the at least one processor to obtain information related to the vehicle.", "The information may include color information of the vehicle.", "The instructions may cause the at least one processor to provide the color information related to the vehicle for presentation in at least one user interface to at least one requester terminal.", "The instructions may cause the at least one processor to instruct the requester terminal to display at least one user interface element in the user interface based on the color information of the vehicle.", "According to a further aspect of the present disclosure, a method is provided.", "The method may include one or more of the following operations.", "A request for on-demand service may be sent to a server.", "Information of a vehicle related to the request for on-demand service may be obtained.", "The information of the vehicle may include color information of the vehicle.", "A user interface may be generated based on the information of the vehicle by a processor.", "The user interface may include at least one user interface element corresponding to the color information of the vehicle.", "The user interface may be displayed.", "According to another aspect of the present disclosure, a method is provided.", "The method may include one or more of the following operations.", "A vehicle related to a request for on-demand service may be determined.", "Information related to the vehicle may be obtained.", "The information may include color information of the vehicle.", "The color information related to the vehicle may be provided to a requester terminal for presentation in a user interface.", "The requester terminal may be instructed to display at least one user interface element in the user interface based on the color information of the vehicle.", "Additional features will be set forth in part in the description which follows, and in part will become apparent to those skilled in the art upon examination of the following and the accompanying drawings or may be learned by production or operation of the examples.", "The features of the present disclosure may be realized and attained by practice or use of various aspects of the methodologies, instrumentalities and combinations set forth in the detailed examples discussed below." ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application is a Continuation of International Application No.", "PCT/CN/2017/082511, filed on Apr.", "28, 2017, which claims priority of Chinese Patent Application No.201611193696.X, filed on Dec. 21, 2016, the contents of which are incorporated herein by reference.", "TECHNICAL FIELD The present disclosure generally relates to online on-demand services and platforms, and in particular, to systems and methods for providing and displaying vehicle information for online on-demand services and platforms based on color information of vehicles.", "BACKGROUND On-demand services, such as online ridesharing services and delivery services, have become increasingly popular because of their convenience.", "A service platform that provides such services may need to process a high volume of complex data and conduct a massive amount of computation to automatically process and fulfill user requests.", "To provide scalable and real-time services to millions of users, such a service platform may need to perform the processing and computation using pattern recognition techniques, machine learning techniques, data mining techniques, predictive analytics, user behavior analytics, cloud computing techniques, and other computational techniques.", "SUMMARY According to an aspect of the present disclosure, a system is provided.", "The system may include at least one storage medium and at least one processor configured to communicate with the at least one storage medium.", "The at least one storage medium may include a set of instructions for displaying vehicle information for an on-demand service.", "When the at least one processor executing the set of instructions, the at least one processor may be directed to perform one or more of the following operations.", "The at least one processor may send a request for on-demand service to a server.", "The at least one processor may obtain information of a vehicle related to the request for on-demand service.", "The information of the vehicle may include color information of the vehicle.", "The at least one processor may generate a user interface based on the information of the vehicle.", "The user interface may include at least one user interface element corresponding to the color information of the vehicle.", "In some embodiments, the system may further include a display configured to present the user interface.", "In some embodiments, the information of the vehicle may further include text information and/or logo information of the vehicle.", "The display may further display text information and/or logo information of the vehicle based on the color information of the vehicle.", "In some embodiments, the at least one processor may be further directed to obtain descriptive information corresponding to a color of the vehicle, and to determine the color information of the vehicle based on the descriptive information.", "In some embodiments, the at least one processor may be further directed to obtain image data of the vehicle, and to determine the color information of the vehicle based on the image data.", "According to another aspect of the present disclosure, a non-transitory machine-readable storage medium may include instructions.", "When the non-transitory machine-readable storage medium accessed by at least one processor of an online on-demand service platform from a requester terminal, the instructions may cause the at least one processor to perform one or more of the following operations.", "The instructions may cause the at least one processor to receive a request for on-demand service.", "The instructions may cause the at least one processor to determine a vehicle related to the request for on-demand service.", "The instructions may cause the at least one processor to obtain information related to the vehicle.", "The information may include color information of the vehicle.", "The instructions may cause the at least one processor to provide the color information related to the vehicle for presentation in at least one user interface to at least one requester terminal.", "The instructions may cause the at least one processor to instruct the requester terminal to display at least one user interface element in the user interface based on the color information of the vehicle.", "According to a further aspect of the present disclosure, a method is provided.", "The method may include one or more of the following operations.", "A request for on-demand service may be sent to a server.", "Information of a vehicle related to the request for on-demand service may be obtained.", "The information of the vehicle may include color information of the vehicle.", "A user interface may be generated based on the information of the vehicle by a processor.", "The user interface may include at least one user interface element corresponding to the color information of the vehicle.", "The user interface may be displayed.", "According to another aspect of the present disclosure, a method is provided.", "The method may include one or more of the following operations.", "A vehicle related to a request for on-demand service may be determined.", "Information related to the vehicle may be obtained.", "The information may include color information of the vehicle.", "The color information related to the vehicle may be provided to a requester terminal for presentation in a user interface.", "The requester terminal may be instructed to display at least one user interface element in the user interface based on the color information of the vehicle.", "Additional features will be set forth in part in the description which follows, and in part will become apparent to those skilled in the art upon examination of the following and the accompanying drawings or may be learned by production or operation of the examples.", "The features of the present disclosure may be realized and attained by practice or use of various aspects of the methodologies, instrumentalities and combinations set forth in the detailed examples discussed below.", "BRIEF DESCRIPTION OF THE DRAWINGS The present disclosure is further described in terms of exemplary embodiments.", "These exemplary embodiments are described in detail with reference to the drawings.", "These embodiments are non-limiting exemplary embodiments, in which like reference numerals represent similar structures throughout the several views of the drawings, and wherein: FIG.", "1 is a block diagram illustrating an exemplary online on-demand service system according to some embodiments of the present disclosure; FIG.", "2A is a schematic diagram illustrating exemplary hardware and/or software components of an exemplary computing device according to some embodiments of the present disclosure; FIG.", "2B is a schematic diagram illustrating exemplary hardware and/or software components of an exemplary mobile device according to some embodiments of the present disclosure; FIG.", "3 is a block diagram illustrating an exemplary requester terminal according to some embodiments of the present disclosure; FIG.", "4 is a block diagram illustrating an exemplary server according to some embodiments of the present disclosure; FIG.", "5 is a flowchart illustrating an exemplary process for presenting information about a vehicle for an on-demand service according to some embodiments of the present disclosure; FIG.", "6 is a flowchart illustrating an exemplary process for presenting information about a vehicle for on-demand service according to some embodiments of the present disclosure; FIG.", "7 is a flowchart illustrating an exemplary process for presenting information about a vehicle for on-demand service according to some embodiments of the present disclosure; FIG.", "8 is a flowchart illustrating an exemplary process for presenting information about a vehicle for on-demand service according to some embodiments of the present disclosure; FIG.", "9 is a flowchart illustrating an exemplary process for presenting vehicle information for an on-demand service according to one embodiment of the present disclosure; FIG.", "10 is a flowchart illustrating an exemplary process for presenting vehicle information for an on-demand service according to another embodiment of the present disclosure; and FIG.", "11 illustrates an exemplary user interface for presenting vehicle information relating to an online on-demand service system according to some embodiments of the present disclosure.", "DETAILED DESCRIPTION The following description is presented to enable any person skilled in the art to make and use the present disclosure, and is provided in the context of a particular application and its requirements.", "Various modifications to the disclosed embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be applied to other embodiments and applications without departing from the spirit and scope of the present disclosure.", "Thus, the present disclosure is not limited to the embodiments shown, but is to be accorded the widest scope consistent with the claims.", "The terminology used herein is for the purpose of describing particular example embodiments only and is not intended to be limiting.", "As used herein, the singular forms “a,” “an,” and “the” may be intended to include the plural forms as well, unless the context clearly indicates otherwise.", "It will be further understood that the terms “comprise,” “comprises,” and/or “comprising,” “include,” “includes,” and/or “including,” when used in this specification, specify the presence of stated features, integers, operations, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, operations, operations, elements, components, and/or groups thereof.", "These and other features, and characteristics of the present disclosure, as well as the methods of operation and functions of the related elements of structure and the combination of parts and economies of manufacture, may become more apparent upon consideration of the following description with reference to the accompanying drawings, all of which form a part of this disclosure.", "It is to be expressly understood, however, that the drawings are for the purpose of illustration and description only and are not intended to limit the scope of the present disclosure.", "It is understood that the drawings are not to scale.", "The flowcharts used in the present disclosure illustrate operations that systems implement according to some embodiments in the present disclosure.", "It is to be expressly understood, the operations of the flowchart may be implemented not in order.", "Conversely, the operations may be implemented in inverted order, or simultaneously.", "Moreover, one or more other operations may be added to the flowcharts.", "One or more operations may be removed from the flowcharts.", "Moreover, while the system and method in the present disclosure is described primarily in regard to allocate a set of sharable orders, it should also be understood that this is only one exemplary embodiment.", "The system or method of the present disclosure may be applied to any other kind of on-demand service.", "For example, the system or method of the present disclosure may be applied to transportation systems of different environments including land, ocean, aerospace, or the like, or any combination thereof.", "The vehicle of the transportation systems may include a taxi, a private car, a hitch, a bus, a train, a bullet train, a high speed rail, a subway, a vessel, an aircraft, a spaceship, a hot-air balloon, a driverless vehicle, or the like, or any combination thereof.", "The transportation system may also include any transportation system for management and/or distribution, for example, a system for sending and/or receiving an express.", "The application of the system or method of the present disclosure may include a webpage, a plug-in of a browser, a client terminal, a custom system, an internal analysis system, an artificial intelligence robot, or the like, or any combination thereof.", "The term “passenger,” “requester,” “requestor,” “service requester,” “service requestor” and “customer” in the present disclosure are used interchangeably to refer to an individual, an entity or a tool that may request or order a service.", "Also, the term “driver,” “provider,” “service provider,” and “supplier” in the present disclosure are used interchangeably to refer to an individual, an entity or a tool that may provide a service or facilitate the providing of the service.", "The term “user” in the present disclosure may refer to an individual, an entity or a tool that may request a service, order a service, provide a service, or facilitate the providing of the service.", "For example, the user may be a passenger, a driver, an operator, or the like, or any combination thereof.", "In the present disclosure, “passenger” and “passenger terminal” may be used interchangeably, and “driver” and “driver terminal” may be used interchangeably.", "The term “request,” “service,” “service request,” and “order” in the present disclosure are used interchangeably to refer to a request that may be initiated by a passenger, a requester, a service requester, a customer, a driver, a provider, a service provider, a supplier, or the like, or any combination thereof.", "The service request may be accepted by any one of a passenger, a requester, a service requester, a customer, a driver, a provider, a service provider, or a supplier.", "The service request may be chargeable or free.", "The positioning technology used in the present disclosure may be based on a global positioning system (GPS), a global navigation satellite system (GLONASS), a compass navigation system (COMPASS), a Galileo positioning system, a quasi-zenith satellite system (QZSS), a wireless fidelity (WiFi) positioning technology, or the like, or any combination thereof.", "One or more of the above positioning systems may be used interchangeably in the present disclosure.", "Conventionally, a service requester of an on-demand service (e.g., a rider of a ridesharing service) may have to recognize a service provider (e.g., a driver that that accepts a ride request) based on certain information related to the service provider, such as a picture of the service provider, a license plate number of a vehicle of the service provider, etc.", "Such information is not visualized.", "As a result, it would be time-consuming for the service requester to identify the service provider based on such information.", "Thus, it may be desirable to provide mechanisms that enable the service requester to recognize the service provider in a more prompt and efficient manner.", "Aspects of the present disclosure address the above-mentioned deficiencies by providing for mechanisms (e.g., systems, methods, and media) for displaying vehicle information for on-demand services.", "Upon receiving a request for a service initiated by a service requester, the mechanisms can generate color information of a vehicle to be used to provide the service (e.g., a ride, delivery).", "The mechanisms can then cause the color information to be presented on a user terminal (e.g., a mobile phone) associated with the service requester.", "For example, the mechanisms can generate one or more user interfaces including one or more user interface elements showing a color of the vehicle.", "More particularly, for example, an icon or any other visual representation of the vehicle can be displayed in the color of the vehicle.", "Additionally or alternatively, text information related to the vehicle (e.g., a description of the vehicle) can be presented in the color of the vehicle.", "As such, visualized information of the vehicle is presented to enable the service requester to better identify the vehicle.", "It should be noted that on-demand service, such as online taxi hailing including taxi transportation services, is a new form of service rooted only in post-Internet era.", "It provides technical solutions to users and service providers that could raise only in post-Internet era.", "In pre-Internet era, for example, when a user hails a taxi on street, the taxi request and acceptance occur only between the passenger and one taxi driver that sees the passenger.", "If the passenger hails a taxi through telephone call, the service request and acceptance may occur only between the passenger and one service provider (e.g., one taxi company or agent).", "Online taxi, however, allows a user of the service to real-time and automatic distribute a service request to a vast number of individual service providers (e.g., taxi) distance away from the user.", "It also allows a plurality of service providers to respond to the service request simultaneously and in real-time.", "Therefore, through Internet, the online on-demand systems may provide a much more efficient transaction platform for the users and the service providers that may never met in a traditional pre-Internet transportation service system.", "FIG.", "1 is a block diagram of an exemplary online on-demand service system 100 according to some embodiments of the present disclosure.", "For example, the online on-demand service system 100 may be an online on-demand service platform for on-demand services such as taxi hailing service, goods delivery service, chauffeur service, express car service, carpool service, bus service, short-term driver-renting service, and shuttle service.", "The online on-demand service system 100 may be an online platform including a server 110, a network 120, a requester terminal 130, a provider terminal 140, and a data storage 150.The server 110 may include a processing engine 112.The server 110 may be a single server, or a server group.", "The server group may be centralized, or distributed (e.g., the server 110 may be a distributed system).", "In some embodiments, the server 110 may be local or remote.", "For example, the server 110 may access information and/or data stored in the requester terminal 130, the provider terminal 140, and/or the data storage 150 via the network 120.As another example, the server 110 may be directly connected to the requester terminal 130, the provider terminal 140, and/or the data storage 150 to access stored information and/or data.", "In some embodiments, the server 110 may be implemented on a cloud platform.", "Merely by way of example, the cloud platform may include a private cloud, a public cloud, a hybrid cloud, a community cloud, a distributed cloud, an inter-cloud, a multi-cloud, or the like, or any combination thereof.", "In some embodiments, the server 110 may include a processing engine 112.The processing engine 112 may process information and/or data related to the service request to perform one or more functions described in the present disclosure.", "In some embodiments, the processing engine 112 may include one or more processing engines (e.g., single-core processing engine(s) or multi-core processor(s)).", "Merely by way of example, the processing engine 112 may include a central processing unit (CPU), an application-specific integrated circuit (ASIC), an application-specific instruction-set processor (ASIP), a graphics processing unit (GPU), a physics processing unit (PPU), a digital signal processor (DSP), a field programmable gate array (FPGA), a programmable logic device (PLD), a controller, a microcontroller unit, a reduced instruction-set computer (RISC), a microprocessor, or the like, or any combination thereof.", "The network 120 may facilitate exchange of information and/or data.", "In some embodiments, one or more components in the online on-demand service system 100 (e.g., the server 110, the requester terminal 130, the provider terminal 140, and the data storage 150) may send information and/or data to other component(s) in the online on-demand service system 100 via the network 120.For example, the server 110 may obtain/acquire service request from the requester terminal 130 via the network 120.In some embodiments, the network 120 may be any type of wired or wireless network, or combination thereof.", "Merely by way of example, the network 130 may include a cable network, a wireline network, an optical fiber network, a tele communications network, an intranet, an Internet, a local area network (LAN), a wide area network (WAN), a wireless local area network (WLAN), a metropolitan area network (MAN), a wide area network (WAN), a public telephone switched network (PSTN), a Bluetooth network, a ZigBee network, a near field communication (NFC) network, or the like, or any combination thereof.", "In some embodiments, the network 120 may include one or more network access points.", "For example, the network 120 may include wired or wireless network access points such as base stations and/or internet exchange points 120-1, 120-2, .", ".", ".", ", through which one or more components of the online on-demand service system 100 may be connected to the network 120 to exchange data and/or information.", "In some embodiments, a requester may be a user of the requester terminal 130.In some embodiments, the user of the requester terminal 130 may be someone other than the requester.", "For example, a user A of the requester terminal 130 may use the requester terminal 130 to send a service request for a user B, or receive service and/or information or instructions from the server 110.In some embodiments, a provider may be a user of the provider terminal 140.In some embodiments, the user of the provider terminal 140 may be someone other than the provider.", "For example, a user C of the provider terminal 140 may user the provider terminal 140 to receive a service request for a user D, and/or information or instructions from the server 110.In some embodiments, “requester” and “requester terminal” may be used interchangeably, and “provider” and “provider terminal” may be used interchangeably.", "In some embodiments, the requester terminal 130 may include a mobile device 130-1, a tablet computer 130-2, a laptop computer 130-3, a built-in device in a motor vehicle 130-4, or the like, or any combination thereof.", "In some embodiments, the mobile device 130-1 may include a smart home device, a wearable device, a smart mobile device, a virtual reality device, an augmented reality device, or the like, or any combination thereof.", "In some embodiments, the smart home device may include a smart lighting device, a control device of an intelligent electrical apparatus, a smart monitoring device, a smart television, a smart video camera, an interphone, or the like, or any combination thereof.", "In some embodiments, the wearable device may include a smart bracelet, a smart footgear, a smart glass, a smart helmet, a smart watch, a smart clothing, a smart backpack, a smart accessory, or the like, or any combination thereof.", "In some embodiments, the smart mobile device may include a smartphone, a personal digital assistance (PDA), a gaming device, a navigation device, a point of sale (POS) device, or the like, or any combination thereof.", "In some embodiments, the virtual reality device and/or the augmented reality device may include a virtual reality helmet, a virtual reality glass, a virtual reality patch, an augmented reality helmet, an augmented reality glass, an augmented reality patch, or the like, or any combination thereof.", "For example, the virtual reality device and/or the augmented reality device may include a Google Glass, an Oculus Rift, a Hololens, a Gear VR, etc.", "In some embodiments, built-in device in the motor vehicle 130-4 may include an onboard computer, an onboard television, etc.", "In some embodiments, the requester terminal 130 may be a device with positioning technology for locating the position of the requester and/or the requester terminal 130.In some embodiments, the provider terminal 140 may be similar to, or the same device as the requester terminal 130.In some embodiments, the provider terminal 140 may be a device with positioning technology for locating the position of the provider and/or the provider terminal 140.In some embodiments, the requester terminal 130 and/or the provider terminal 140 may communicate with other positioning device to determine the position of the requester, the requester terminal 130, the provider, and/or the provider terminal 140.In some embodiments, the requester terminal 130 and/or the provider terminal 140 may send positioning information to the server 110.The data storage 150 may store data and/or instructions.", "In some embodiments, the data storage 150 may store data obtained from the requester terminal 130 and/or the provider terminal 140.In some embodiments, the data storage 150 may store data and/or instructions that the server 110 may execute or use to perform exemplary methods described in the present disclosure.", "In some embodiments, data storage 150 may include a mass storage, a removable storage, a volatile read-and-write memory, a read-only memory (ROM), or the like, or any combination thereof.", "Exemplary mass storage may include a magnetic disk, an optical disk, a solid-state drives, etc.", "Exemplary removable storage may include a flash drive, a floppy disk, an optical disk, a memory card, a zip disk, a magnetic tape, etc.", "Exemplary volatile read-and-write memory may include a random access memory (RAM).", "Exemplary RAM may include a dynamic RAM (DRAM), a double date rate synchronous dynamic RAM (DDR SDRAM), a static RAM (SRAM), a thyristor RAM (T-RAM), and a zero-capacitor RAM (Z-RAM), etc.", "Exemplary ROM may include a mask ROM (MROM), a programmable ROM (PROM), an erasable programmable ROM (EPROM), an electrically erasable programmable ROM (EEPROM), a compact disk ROM (CD-ROM), and a digital versatile disk ROM, etc.", "In some embodiments, the data storage 150 may be implemented on a cloud platform.", "Merely by way of example, the cloud platform may include a private cloud, a public cloud, a hybrid cloud, a community cloud, a distributed cloud, an inter-cloud, a multi-cloud, or the like, or any combination thereof.", "In some embodiments, the data storage 150 may be connected to the network 120 to communicate with one or more components in the online on-demand service system 100 (e.g., the server 110, the requester terminal 130, the provider terminal 140, etc.).", "One or more components in the online on-demand service system 100 may access the data or instructions stored in the data storage 150 via the network 120.In some embodiments, the data storage 150 may be directly connected to or communicate with one or more components in the online on-demand service system 100 (e.g., the server 110, the requester terminal 130, the provider terminal 140, etc.).", "In some embodiments, the data storage 150 may be part of the server 110.In some embodiments, one or more components in the online on-demand service system 100 (e.g., the server 110, the requester terminal 130, the provider terminal 140, etc.)", "may have a permission to access the data storage 150.In some embodiments, one or more components in the online on-demand service system 100 may read and/or modify information related to the requester, provider, and/or the public when one or more conditions are met.", "For example, the server 110 may read and/or modify one or more users' information after a service.", "As another example, the provider terminal 140 may access information related to the requester when receiving a service request from the requester terminal 130, but the provider terminal 140 may not modify the relevant information of the requester.", "In some embodiments, information exchanging of one or more components in the online on-demand service system 100 may be achieved by way of requesting a service.", "The object of the service request may be any product.", "In some embodiments, the product may be a tangible product, or an intangible product.", "The tangible product may include food, medicine, commodity, chemical product, electrical appliance, clothing, car, housing, luxury, or the like, or any combination thereof.", "The intangible product may include a service product, a financial product, a knowledge product, an internet product, or the like, or any combination thereof.", "The internet product may include an individual host product, a web product, a mobile internet product, a commercial host product, an embedded product, or the like, or any combination thereof.", "The mobile internet product may be implemented as a software of a mobile terminal, a program, a system, or the like, or any combination thereof.", "The mobile terminal may include a tablet computer, a laptop computer, a mobile phone, a personal digital assistance (PDA), a smart watch, a point of sale (POS) device, an onboard computer, an onboard television, a wearable device, or the like, or any combination thereof.", "For example, the product may be any software and/or application used in the computer or mobile phone.", "The software and/or application may relate to socializing, shopping, transporting, entertainment, learning, investment, or the like, or any combination thereof.", "In some embodiments, the software and/or application related to transporting may include a traveling software and/or application, a vehicle scheduling software and/or application, a mapping software and/or application, etc.", "In the vehicle scheduling software and/or application, the vehicle may include a horse, a carriage, a rickshaw (e.g., a wheelbarrow, a bike, a tricycle, etc.", "), a car (e.g., a taxi, a bus, a private car, etc.", "), a train, a subway, a vessel, an aircraft (e.g., an airplane, a helicopter, a space shuttle, a rocket, a hot-air balloon, etc.", "), or the like, or any combination thereof.", "FIG.", "2A is a schematic diagram illustrating exemplary hardware and/or software components of an exemplary computing device 200A on which the processing engine 112 may be implemented according to some embodiments of the present disclosure.", "As illustrated in FIG.", "2A, the computing device 200A may include a processor 201, a storage 203, an input/output (I/O) 205, and a communication port 207.The processor 201 may execute computer instructions (e.g., program code) and perform functions of the processing engine 112 in accordance with techniques described herein.", "The computer instructions may include, for example, routines, programs, objects, components, data structures, procedures, modules, and functions, which perform particular functions described herein.", "For example, the processor 201 may process information of a vehicle obtained from the server 110, the requester terminal 130, the provider terminal 140, the data storage 150, and/or any other component of the online on-demand service system 100.In some embodiments, the processor 201 may include one or more hardware processors, such as a microcontroller, a microprocessor, a reduced instruction set computer (RISC), an application specific integrated circuits (ASICs), an application-specific instruction-set processor (ASIP), a central processing unit (CPU), a graphics processing unit (GPU), a physics processing unit (PPU), a microcontroller unit, a digital signal processor (DSP), a field programmable gate array (FPGA), an advanced RISC machine (ARM), a programmable logic device (PLD), any circuit or processor capable of executing one or more functions, or the like, or any combinations thereof.", "Merely for illustration, only one processor is described in the computing device 200A.", "However, it should be noted that the computing device 200A in the present disclosure may also include multiple processors, thus operations and/or method operations that are performed by one processor as described in the present disclosure may also be jointly or separately performed by the multiple processors.", "For example, if in the present disclosure the processor of the computing device 200A executes both operation A and operation B, it should be understood that operation A and operation B may also be performed by two or more different processors jointly or separately in the computing device 200A (e.g., a first processor executes operation A and a second processor executes operation B, or the first and second processors jointly execute operations A and B).", "The storage 203 may store data/information obtained from the server 110, the requester terminal 130, the provider terminal 140, the data storage 150, and/or any other component of the online on-demand service system 100.In some embodiments, the storage 203 may include a mass storage, a removable storage, a volatile read-and-write memory, a read-only memory (ROM), or the like, or any combination thereof.", "For example, the mass storage may include a magnetic disk, an optical disk, a solid-state drives, etc.", "The removable storage may include a flash drive, a floppy disk, an optical disk, a memory card, a zip disk, a magnetic tape, etc.", "The volatile read-and-write memory may include a random access memory (RAM).", "The RAM may include a dynamic RAM (DRAM), a double date rate synchronous dynamic RAM (DDR SDRAM), a static RAM (SRAM), a thyristor RAM (T-RAM), and a zero-capacitor RAM (Z-RAM), etc.", "The ROM may include a mask ROM (MROM), a programmable ROM (PROM), an erasable programmable ROM (EPROM), an electrically erasable programmable ROM (EEPROM), a compact disk ROM (CD-ROM), and a digital versatile disk ROM, etc.", "In some embodiments, the storage 203 may store one or more programs and/or instructions to perform exemplary methods described in the present disclosure.", "For example, the storage 203 may store a program for the processing engine 112 for determining a color of a vehicle based on its image.", "The I/O 205 may input and/or output signals, data, information, etc.", "In some embodiments, the I/O 205 may enable a user interaction with the processing engine 112.In some embodiments, the I/O 205 may include an input device and an output device.", "Examples of the input device may include a keyboard, a mouse, a touch screen, a microphone, or the like, or any combination thereof.", "Examples of the output device may include a display device, a loudspeaker, a printer, a projector, or the like, or any combination thereof.", "Examples of the display device may include a liquid crystal display (LCD), a light-emitting diode (LED)-based display, a flat panel display, a curved screen, a television device, a cathode ray tube (CRT), a touch screen, or the like, or any combination thereof.", "The communication port 207 may be connected to a network (e.g., the network 120) to facilitate data communications.", "The communication port 207 may establish connections between the processing engine 112 and the requester terminal 130, the provider terminal 140, and/or the data storage 150.The connection may be a wired connection, a wireless connection, any other communication connection that can enable data transmission and/or reception, and/or any combination of these connections.", "The wired connection may include, for example, an electrical cable, an optical cable, a telephone wire, or the like, or any combination thereof.", "The wireless connection may include, for example, a Bluetooth™ link, a Wi-Fi™ link, a WiMax™ link, a WLAN link, a ZigBee link, a mobile network link (e.g., 3G, 4G, 5G, etc.", "), or the like, or any combination thereof.", "In some embodiments, the communication port 207 may be and/or include a standardized communication port, such as RS232, RS485, etc.", "In some embodiments, the communication port 207 may be a specially designed communication port.", "For example, the communication port 207 may be designed in accordance with the digital imaging and communications in medicine (DICOM) protocol.", "FIG.", "2B is a schematic diagram illustrating exemplary hardware and/or software components of an exemplary mobile device 200B on which the requester terminal 130 may be implemented according to some embodiments of the present disclosure.", "As illustrated in FIG.", "2B, the mobile device 200B may include a communication platform 209, a display 213, a graphic processing unit (GPU) 215, a central processing unit (CPU) 217, an I/O 219, a memory 221, and a storage 227.In some embodiments, any other suitable component, including but not limited to a system bus or a controller (not shown), may also be included in the mobile device 200B.", "In some embodiments, a mobile operating system 223 (e.g., iOS™, Android™, Windows Phone™, etc.)", "and one or more applications 225 may be loaded into the memory 221 from the storage 227 in order to be executed by the CPU 217.The applications 225 may include a browser or any other suitable mobile apps for receiving and rendering information related to image processing or other information from the processing engine 112.User interactions with the information stream may be achieved via the I/O 219 and provided to the processing engine 112 and/or other components of the online on-demand service system 100 via the network 120.To implement various modules, units, and their functionalities described in the present disclosure, computer hardware platforms may be used as the hardware platform(s) for one or more of the elements described herein.", "A computer with user interface elements may be used to implement a personal computer (PC) or any other type of work station or terminal device.", "A computer may also act as a server if appropriately programmed.", "FIG.", "3 is a block diagram illustrating an exemplary requester terminal according to some embodiments of the present disclosure.", "The requester terminal 130 may include an acquisition module 310, a determination module 320, a display module 330, and a transmitting module 340.Each module may include hardware circuitry that is designed to perform the following actions, a set of instructions stored in one or more storage media, and/or any combination of the hardware circuitry and the one or more storage media.", "The acquisition module 310 may acquire request and/or information related to the online on-demand service system 100.The request may be a request of an on-demand service.", "For example, the on-demand service may be a transportation service by a taxi, a private vehicle, a bus, a truck, and/or any other vehicle.", "As another example, the on-demand service may be a test drive service, a designated driving service, or the like, or any combination thereof.", "As still another example, the on-demand service may be an on-line delivery service, such as a meal delivery service booked on-line, a delivery service for on-line shopping, or the like, or any combination thereof.", "As yet another example, the on-demand service may be a service of taking an object from one place to another in a vehicle, such as a goods delivery service.", "The request of the on-demand service may include a real-time request, an appointment request, or a pending request.", "For example, the real-time request may be a request that requires a service provider to immediately process and start the service, and/or a service of which the requester wishes to receive the service at the present moment or at a defined time reasonably close to the present moment for an ordinary person in the art.", "For example, a request may be a real-time request if the defined time is shorter than a threshold value, such as 1 minute, 5 minutes, 10 minutes or 20 minutes.", "The appointment request may refer to a request that does not require the service provider to immediately start the service and/or the requester wishes and/or expects to receive the service at a defined time which is reasonably long from the present moment for the ordinary person in the art.", "For example, a service request may be an appointment request if the defined time is longer than a threshold value, such as 20 minutes, 2 hours, 1 day, etc.", "In some embodiments, the requester terminal 130 may define the real-time request or the appointment request based on a time threshold.", "The time threshold may be default settings of the online on-demand service system 100, or may be adjustable depending on different situations.", "For example, in a traffic peak period, the time threshold may be relatively small (e.g., 10 minutes, meaning that the requested service may be delivered within 10 minutes to qualify as a real-time service), otherwise in idle period (e.g., 10:00-12:00 am), the time threshold may be relatively great (e.g., 1 hour).", "The pending request may be an on-going request which is in progress by a service provider at the present moment.", "The request for on-demand service may include a start location (e.g., a current location of the service requester, an appointed pick-up location), a destination, a required service time, or the like, or any combination thereof.", "The destination may be expressly defined by the requester.", "Alternatively, the requester does not have to be associated with a destination.", "The information related to the online on-demand service system 100 may include information of a vehicle related to the request for on-demand service.", "The vehicle may include a non-motor vehicle (e.g., a bicycle or a tricycle), a motor vehicle (e.g., a car or a truck), a watercraft (e.g., a ship or a boat) and/or an aircraft.", "In some embodiments, the vehicle may be self-driven.", "The information of the vehicle may include color information, text information, logo information, image data, or the like, or any combination thereof.", "The color information may include any information about one or more colors of the vehicle, such as descriptive information of a color of the vehicle, a category of the color, a color code, spectral coordinate information, or the like, or any combination thereof.", "Descriptive information corresponding to a color may include one or more numbers, characters, symbols, and/or any other data that can be used to describe the color.", "The description information may include any information related to a representation of the color.", "For example, the descriptive information of the color can include a description of the color, such as “red,” “green,” or the like.", "As another example, the descriptive information of the color can include one or more parameters and/or values that can be used to determine the color.", "In a more particular example, the descriptive information can include parsed character data corresponding to the color.", "The parsed character data may be in any suitable markup language, including but not limited to Extensible Markup Language (XML), HyperText Markup Language (HTML), and Standard Generalized Markup Language (SGML).", "In another more particular example, the descriptive information of the color may include color code information, such as a Red-Green-Blue (RGB) code, a Hue-Saturation-Value (HSV) code, an HTML color code, a Hex triplet code, or the like, or any combination thereof.", "Each of the color code can include one or more values defining the color and/or one or more components of the color.", "For example, an RGB code for “orange” may be (255, 165, 0).", "In still another more particular example, the descriptive information of the color can include spectral coordinate information related to the color, such as a wavelength and/or a frequency of the color.", "For example, the wavelength of red may vary from 635 nm to 700 nm.", "The frequency of red may vary from 480 THz to 430 THz.", "In some embodiments, the color information of a color can include a variation of a color (e.g., “red,” “orange,” “grey,” “blue,” “yellow,” “green,” or the like, or any combination thereof).", "For example, variations of “orange” may include “orange,” “sun orange,” “honey orange,” “tropical orange,” “tangerine,” or the like, or any combination thereof.", "In some embodiments, one or more portions of the color information of the vehicle may be provided by a service provider associated with the vehicle.", "For example, the service provider may input the color of the vehicle via the provider terminal 140.In some embodiments, the server and/or the provider terminal 140 can prompt the service provider to provide color information about the vehicle when the service provider registers an account and/or the vehicle via the online on-demand service system 100 (e.g., by presenting one or more user interfaces).", "In some embodiments, the color information can be determined by one or more components in the online on-demand service system 100.For example, the color information may be determined by the determination module 320 and/or the determination module 420 based on image data of the vehicle (e.g., one or more images of the vehicle), registration and/or title information of the vehicle, etc.", "The text information may include route information, vehicle information, diver information, or the like, or any combination thereof.", "The route information may include a start location, a destination, a mileage, a pickup time, an estimated fee, a unit price (e.g., a price per unit distance), a congested portion of the route (e.g., a congested road due to traffic peak), an estimated distance of between the vehicle and the service requester, an estimated arrival time of the vehicle, or the like, or any combination thereof.", "The vehicle information may include a license plate number of the vehicle, a color of the vehicle, a brand name of the vehicle, a number of seats in a vehicle, a trunk volume, a load capacity (e.g., a weight of products that the vehicle can carry), or the like, or any combination thereof.", "The service provider information may include name information (e.g., a first name, a last name, a nickname, a username), score information (e.g., a score marked by service requesters), contact information (e.g., a cell phone number, an email address), an identity code (ID), a country, a city, a gender, a date of birth, etc.", "The logo information may include a brand name and/or model of vehicle, a logo image and/or a logo icon corresponding to the brand of the vehicle, or the like, or any combination thereof.", "Exemplary brands of the vehicle may include Benz™, Volkswagen™, Toyota™, Hyundai™, Honda™, Ford™, etc.", "The determination module 320 may determine a color of a vehicle related to a request for on-demand service.", "For example, the determination module 320 may determine the color based on descriptive information corresponding to a color of the vehicle, an image of the vehicle, or the like, or any combination thereof.", "For example, the determination module 320 can determine the color by performing one or more operations described in connection with FIGS.", "6 and 7.The display module 330 may present one or more user interfaces related to the online on-demand service system 100.The user interfaces may include, for example, a user interface for requesting services (e.g., scheduling a ride), a user interface for presentation when a user is waiting for a ride, a user interface for presentation during a ride, etc.", "Each of the user interface(s) may include one or more user interface elements related to a vehicle corresponding to a request for on-demand service.", "Each of the user interface elements may be in any other color or a combination of any number of colors.", "Each of the user interface elements may have any regular shape (e.g., circular, triangular, quadrilateral, pentagon, hexagon, etc.)", "or any irregular shape (e.g., an element like a vehicle, etc.).", "Each of the user interface elements may include a graph, an icon, a text field, a button, a checkbox, an image, or the like, or any combination thereof.", "In some embodiments, the user interface element may include an icon of the vehicle, text information of the vehicle, and a logo of the vehicle (e.g., a logo corresponding to a brand and/or model of the vehicle).", "In some embodiments, the display module 330 can present a user interface 1100 as illustrated in FIG.", "11.The transmitting module 340 may transmit information and/or request to one or more components in the online on-demand service system 100.For example, the transmitting module 340 may transmit a request for on-demand service to the server 110 via the network 120.As another example, the transmitting module 340 may transmit a request to the server 110 to determine color information of a vehicle.", "FIG.", "4 is a block diagram illustrating an exemplary server according to some embodiments of the present disclosure.", "The server 110 may include an acquisition module 410, a determination module 420, and a transmitting module 430.Each module may include hardware circuitry that is designed to perform the following actions, a set of instructions stored in one or more storage media, and/or any combination of the hardware circuitry and the one or more storage media.", "The acquisition module 410 may acquire requests and/or information related to the online on-demand service system 100.The requests may include a request for an on-demand service, a request for obtaining information, a request for processing information, or the like, or any combination thereof.", "For example, the acquisition module 410 may receive a request for an on-demand service from a service requester via the requester terminal 130.As another example, the acquisition module 410 may obtain a request from the requester terminal 130 for obtaining information of a vehicle.", "As still another example, the acquisition module 410 may obtain a request from the requester terminal 130 for determining a color of a vehicle.", "The request and/or information related to the online on-demand service system 100 may be similar with those described in FIG.", "3 and is not repeated.", "The determination module 420 may determine a vehicle related to a request for on-demand service, a color of a vehicle, or the like.", "The vehicle related to the request for on-demand service may be determined based on distances between available vehicles and the service requester, required time for available vehicles to pick up the service requester, score information of the service providers of the available vehicles, user preference information of the service requester, or the like, or any combination thereof.", "The color of the vehicle may be determined based on descriptive information corresponding to a color of the vehicle, an image of the vehicle, or the like, or any combination thereof.", "For example, the determination module 420 can determine the color by performing one or more operations described in connection with FIGS.", "9, and/or 10.The transmitting module 430 may transmit information and/or request to other components in the online on-demand service system 100.For example, the transmitting module 430 may transmit color information of a vehicle to the requester terminal 130 via the network 120.As another example, the transmitting module 430 may transmit an instruction to the requester terminal 130 for displaying a user interface element in a user interface based on the color information of a vehicle.", "In some embodiments, at least two components in the requester terminal 130 and server 110 may be connected to or communicate with each other and/or other components in the online on-demand service system 100 via a wired connection or a wireless connection.", "The wired connection may include a metal cable, an optical cable, a hybrid cable, or the like, or any combination thereof.", "The wireless connection may include a Local Area Network (LAN), a Wide Area Network (WAN), a Bluetooth, a ZigBee, a Near Field Communication (NFC), or the like, or any combination thereof.", "Any two of the modules may be combined as a single module, any one of the modules may be divided into two or more units.", "In some embodiments, the requester terminal 130 and/or the server 110 may include the computing device 200A as illustrated in FIG.", "2A where one or more of the components may be implemented.", "Merely by way of example, the acquisition module 310 and the display module 330 may be implemented on the computing device 200A that is part of the requester terminal 130, and the determination module 320 is implemented in the requester terminal 130 but not as part of computing device 200A.", "It should be noted that the above descriptions of the requester terminal 130 and/or the server 110 are provided for the purposes of illustration, and not intended to limit the scope of the present disclosure.", "For persons having ordinary skills in the art, various modifications and changes in the forms and details of the application of the above method and system may occur without departing from the principles in the present disclosure.", "For example, the requester terminal 130 or the server 110 may include one or more other modules (e.g., a storage module to store data generated by the above modules).", "As another example, one module may perform the functions of two or more modules described above.", "In some embodiments, the acquisition module 310 and the transmitting module 340 may form a module to input and/or output information and request related to the online on-demand service system 100.However, those variations and modifications also fall within the scope of the present disclosure.", "FIG.", "5 is a flowchart illustrating an exemplary process for presenting information about a vehicle for an on-demand service according to some embodiments of the present disclosure.", "In some embodiments, the process 500 may be executed by the online on-demand service system 100.For example, the process 500 may be implemented as a set of instructions (e.g., an application) stored in data storage 150, and/or storage 227.The requester terminal 130 and/or the CPU 217 may execute the set of instructions and may accordingly be directed to perform the process 500.The CPU 217 may be a processor of a computer server supporting an online on-demand service platform.", "The platform may be an Internet-based platform that connects on-demand service providers and requesters through Internet.", "In some embodiments, at least part of the process 500 may be performed by the computing device 200A shown in FIG.", "2A.", "In 502, a request for on-demand service may be obtained.", "The on-demand service may be a delivery service, a taxi transportation service, a test drive service, a designated driving service, or the like, or any combination thereof.", "The request of the on-demand service may include a real-time request, an appointment request, or a pending request, or the like.", "For example, a real-time request for a transportation service may be obtained in 502.For example, the request for on-demand service may include any request as described in connection with FIG.", "3.In some embodiments, 502 may be performed by the acquisition module 310.In 504, the request for on-demand service may be sent to a server.", "In some embodiments, the request for on-demand service may be sent to the server 110 by the transmitting module 340 via the network 120.In 506, information of a vehicle related to the request for on-demand service may be obtained.", "In some embodiments, a service provider may accept the request for on-demand service via a provider terminal (e.g., the provider terminal 140-1, etc.).", "The provider terminal can send one or more messages indicative of acceptance of the request by the service provider.", "In some embodiments, the server 110 may allocate the request to a provider terminal (e.g., the provider terminal 140-2, etc.).", "The information of the vehicle corresponding to the provider terminal may then be sent to the requester terminal 130 via the network 120.In some embodiments, the information may be obtained by the acquisition module 310 from the data storage 150 or the server 110.The information of the vehicle related to the request for on-demand service may include color information, text information, logo information, or the like, or any combination thereof.", "The color information may include descriptive information corresponding to a color of the vehicle, a category of the color, a color code, spectral coordinate information, or the like, or any combination thereof.", "The text information may include basic route information, vehicle information, driver information, or the like, or any combination thereof.", "The logo information may include a logo image and/or a logo icon corresponding to the brand of the vehicle.", "For example, the information of the vehicle may include any information as be described in connection with FIG.", "3.In some embodiments, 506 may be performed by the acquisition module 310.In 508, the requester terminal 130 may generate a user interface based on the information of the vehicle.", "In some embodiments, the user interface can be generated by performing one or more operations described in connection with FIGS.", "6 and 7.The user interface may include a user interface element corresponding to the color information of the vehicle.", "The user interface element corresponding to the color information may have a color that is the same as or similar to the color of the vehicle.", "In some embodiments, a first color may be regarded as being a similar color of a second color when the first color and the second color belong to the same color category.", "For example, “honey orange” and “sun orange” may be similar colors because they are variations of orange.", "In some embodiments, the first color may be regarded as being a similar color of the second color when a similarity between the first color and the second color satisfies a particular criterion or criteria.", "For example, the criterion may include that the similarity is greater than a threshold.", "The similarity between the first color and the second color may be determined based on an RGB Euclidean Distance, an RGB vector angle, an HSV Euclidean Distance, or the like, or any combination thereof.", "The user interface element corresponding to the color information may have any size, shape, and/or form.", "The user interface element corresponding to the color information may include an icon, a graph, text information, or the like, or any combination thereof.", "For example, the user interface elements may include any user interface element as described in connection with FIG.", "3.In some embodiments, user interface element corresponding to the color information may include but is not limited to a vehicle-shaped icon, text information of the vehicle, and a logo of the vehicle.", "The vehicle-shaped icon may have a similar shape with a vehicle.", "Exemplary vehicle may include but is not limited to a horse, a carriage, a rickshaw (e.g., a wheelbarrow, a bike, or a tricycle), a car (e.g., a taxi, a bus, or a private car), a train, a subway, a vessel, and an aircraft (e.g., an airplane, a helicopter, a space shuttle, a rocket, or a hot-air balloon).", "In some embodiments, the shape of the vehicle-shaped icon may be associated with the kind of on-demand service provided in the online on-demand service system 100.For example, as illustrated in FIG.", "11, a vehicle-shaped icon 1101 associated with a car transportation service may have a similar shape with a car.", "The user interface element of the text information of the vehicle may include text information of the vehicle (e.g., route information, vehicle information, diver information, etc.).", "For example, as shown in FIG.", "11, text information elements 1103-1 and 1103-2 can include text indicative of a name of the service provider, a score of the service provider, a license plate number of the vehicle, a color of the vehicle, a brand name of the vehicle, a model of the vehicle, an estimated distance between the vehicle and the service requester, an estimated required time for the vehicle to arrive at the start location, etc.", "In some embodiments, the text and/or other content in the text information elements 1103-1 and 1103-2 can be presented in a color that is the same as or similar to the color of the vehicle.", "The logo of the vehicle may display a logo image or a logo icon of the vehicle.", "The logo may correspond to a brand of the vehicle, a model of the vehicle, etc.", "As illustrated in FIG.", "11, a logo 1105 displays a logo of Benz™ for a Benz™ vehicle.", "In some embodiments, the logo 1105 can be presented in a color that is the same as or similar to the color of the vehicle.", "In some embodiments, the user interface element corresponding to the color information may have a same or similar color with the vehicle in the whole process of the on-demand service.", "For example, the vehicle-shaped icon 1101 illustrated in FIG.", "11 may have a same or similar color with the vehicle from the beginning of service (e.g., when the service requester sends a request) to the ending of the service (e.g., when the vehicle arrives at the destination of the service requester).", "In some embodiments, the user interface element corresponding to the color information may have a same or similar color with the vehicle in at least part of the process of the on-demand service.", "For example, the vehicle-shaped icon 1101 may have a same color or similar color with the vehicle when the vehicle is on the way to pick up the service requester, and change to another color after picking up the service requester.", "In 510, the user interface may be displayed.", "In some embodiments, 510 may be performed by the display module 330.It should be noted that the above descriptions of the process 500 are provided for the purposes of illustration, and not intended to limit the scope of the present disclosure.", "For persons having ordinary skills in the art, various modifications and changes in the forms and details of the application of the above method and system may occur without departing from the principles in the present disclosure.", "In some embodiments, multiple user interface elements may be generated in the user interface in 508.At least one of the multiple user interface elements may correspond to the color information of the vehicle.", "For example, all of the multiple user interface elements may have a same or similar color with the vehicle.", "Alternatively, some of the multiple user interface element may have a same or similar color with the vehicle while the rest may not.", "However, those variations and modifications also fall within the scope of the present disclosure.", "FIG.", "6 is a flowchart illustrating an exemplary process for presenting information about a vehicle for an on-demand service according to some embodiments of the present disclosure.", "In some embodiments, at least part of the process 600 may be performed by one or more components in the requester terminal 130.In 602, descriptive information corresponding to a color of a vehicle related to a request for on-demand service may be obtained.", "The descriptive information corresponding to the color of the vehicle may include a description of the color, parsed character data corresponding to the color, color code information, or the like, or any combination thereof.", "The descriptive information may be obtained by the acquisition module 310 from the data storage 150 and/or the server 110.For example, the descriptive information can include any descriptive information as described in connection with FIGS.", "3 and 5.In 604, the color of the vehicle may be determined based on the descriptive information.", "In some embodiments, the description information corresponding to the color may be transformed to parsed character data by a parsing technology.", "Exemplary parsing technology may include but is not limited to XML parsing technology, XHTML parsing technology, or HTML parsing technology.", "The color of the vehicle may then be determined based on the parsed character data.", "In some embodiments, 604 may be performed by the determination module 320.In 606, a user interface may be generated based on the color of the vehicle.", "The user interface may include a user interface element correspond to the color of the vehicle.", "The user interface element corresponding to the color may have a color that is same as or similar to the color of the vehicle.", "The user interface element may be substantial similar to that described in 508 with reference to FIG.", "5, and is not repeated here.", "FIG.", "7 is a flowchart illustrating an exemplary process for presenting information about a vehicle for an on-demand service according to some embodiments of the present disclosure.", "In some embodiments, at least part of the process 700 may be performed by one or more components in the requester terminal 130.In 702, image data of a vehicle related to a request for on-demand service may be obtained.", "The image data can include one or more still images, moving images (a sequence of video frames), and/or any other data about one or more images.", "In some embodiments, the image data may be obtained by the acquisition module 310 from the data storage 150 and/or the server 110.In 704, a color of the vehicle may be determined based on the image data.", "In some embodiments, the color of the vehicle may be determined by the determination module 320.In some embodiments, the determination of the color of the vehicle based on the image data may be implemented by performing one or more image processing operations.", "Exemplary image processing operations may include but is not limited to image segmenting, image filtering, color identifying, or the like, or any combination thereof.", "The image segmenting may be performed to segment a subarea from the image for color determination.", "The segmented subarea may be an area in the body of the vehicle.", "The image filtering may be performed to filter image noise, such as, a Gaussian noise, a Rayleigh noise, impulse noise, etc.", "The color identifying may be performed to identify the color of the vehicle based on the image data.", "For example, the color of the vehicle may be determined based on a color histogram of an image of the vehicle and a plurality of color templates.", "The color histogram of the image may be determined based on a color code model (e.g., a RGB code model, a HSV code model, a CMYK code model, etc.).", "Each of the plurality of color templates may include color information of the corresponding color.", "The corresponding color may include common vehicle color, such as, “red,” “blue,” “green,” “white,” “black,” “silver,” “grey,” “yellow,” etc.", "The color of the image may be determined by comparing the color histogram of the image and the plurality of color templates.", "Alternatively, the color of the vehicle may be determined based on the plurality of color templates and a color matrix or a color vector of the image.", "The color matrix and the color vector may be determined based on a color code model.", "In 706, a user interface may be generated based on the color of the vehicle.", "The user interface may include a user interface element corresponding to the color of the vehicle.", "Steps 706 and 606 may be performed in a substantially similar manner.", "It should be noted that the above descriptions of the process 700 are provided for the purposes of illustration, and not intended to limit the scope of the present disclosure.", "For persons having ordinary skills in the art, various modifications and changes in the forms and details of the application of the above method and system may occur without departing from the principles in the present disclosure.", "In some embodiments, the color of the image may be determined based on other related technologies, such as, a machine learning technology, a neural network technology, etc.", "FIG.", "8 is a flowchart illustrating an exemplary process for presenting information about a vehicle for an on-demand service according to some embodiments of the present disclosure.", "In some embodiments, the process 800 may be executed by the online on-demand service system 100.For example, the process 800 may be implemented as a set of instructions (e.g., an application) stored in data storage 150, and/or storage 227.The server 110 and/or the CPU 217 may execute the set of instructions and may accordingly be directed to perform the process and/or method 800.The CPU 217 may be a processor of a computer server supporting an online on-demand service platform.", "The platform may be an Internet-based platform that connects on-demand service providers and requesters through Internet.", "In some embodiments, at least part of the process 800 may be performed by the computing device 200A shown in FIG.", "2A.", "In 802, a request for on-demand service may be received.", "The request may correspond to a requester terminal.", "The request for on-demand service may include a start location (e.g., current location of the service requester, an appointed pick-up location), a destination, a required service time, or the like, or any combination thereof.", "For example, the request may be any request as described in connection with FIGS.", "3 and 5.In some embodiments, 802 may be performed by the acquisition module 410.In 804, a vehicle may be determined related to the request for on-demand service.", "In some embodiments, available vehicles may be determined and the vehicle may be selected from the available vehicles.", "The available vehicles may be vehicles which are not providing service for other service requesters in the required service time.", "The available vehicles may be ranked based on one or more ranking criteria, such as, distances between the available vehicles to the start location, required driving time to arrive at the start location, score information of the service providers, user preference information of the service requester, or the like, or any combination thereof.", "The vehicle in response to the request for on-demand service may be determined based on the ranking result.", "For example, a vehicle with smallest distance to the start location may be selected.", "In 806, information of the vehicle may be obtained.", "The information of the vehicle may include color information, text information, logo information, or the like, or any combination thereof.", "In some embodiments, the information may be obtained by the acquisition module 410 from the data storage 150.For example, the information of the vehicle may include any information as described in connection with FIG.", "3 and the relevant descriptions.", "In 808, the information related to the vehicle may be sent to the requester terminal for presentation in a user interface.", "In some embodiments, 808 may be performed by the transmitting module 430.In 810, an instruction may be sent to the requester terminal to display a user interface element corresponding to the color information of the vehicle in the user interface.", "Referring back to FIG.", "5, the user interface element corresponding to the color information of the vehicle may have a same or a similar color with the vehicle.", "The user interface element corresponding to the color information of the vehicle may have any shape, size, or form.", "In some embodiments, the user interface element corresponding to the color information of the vehicle may include but is not limited to a vehicle-shaped icon, text information of the vehicle, or a logo of the vehicle.", "For example, the user interface element corresponding to the color information of the vehicle may be described in connection with FIG.", "5.In some embodiments, 810 may be performed by the transmitting module 430.It should be noted that the above descriptions of the process 800 are provided for the purposes of illustration, and not intended to limit the scope of the present disclosure.", "For persons having ordinary skills in the art, various modifications and changes in the forms and details of the application of the above method and system may occur without departing from the principles in the present disclosure.", "In some embodiments, the requester terminal may be instructed to display multiple user interface elements in 810.At least one of the multiple user interface elements may correspond to the color information of the vehicle.", "However, those variations and modifications also fall within the scope of the present disclosure.", "FIG.", "9 is a flowchart illustrating an exemplary process for presenting vehicle information for an on-demand service according to one embodiment of the present disclosure.", "In some embodiments, at least part of the process 900 may be performed by one or more components in the server 110.In 902, descriptive information corresponding to a color of a vehicle related to a request for on-demand service may be obtained.", "In some embodiments, the descriptive information may be obtained by the acquisition module 410 from the data storage 150.Steps 902 and 602 may be performed in a substantially similar manner.", "In 904, the color of the vehicle may be determined based on the descriptive information.", "In some embodiments, 904 may be performed by the determination module 420.Steps 904 and 604 may be performed in a substantially similar manner.", "In 906, the color of the vehicle may be provided to the requester terminal for presentation in a user interface.", "In some embodiments, 906 may be performed by the transmitting module 430.FIG.", "10 is a flowchart illustrating an exemplary process for presenting vehicle information for an on-demand service according to another embodiment of the present disclosure.", "In some embodiments, at least part of the process 1000 may be performed by one or more components in the server 110.In 1002, image data of a vehicle related to a request for on-demand service may be obtained.", "In some embodiments, 1002 may be performed by the acquisition module 410.In 1004, the color of the vehicle may be determined based on the image data.", "In some embodiments, 1004 may be performed by the determination module 420.Steps 1004 and 704 may be performed in a substantially similar manner.", "In 1006, a user interface may be generated based on the color of the vehicle.", "The user interface may include a user interface element corresponding to the color of the vehicle.", "Steps 1006 and 606 may be performed in a substantially similar manner.", "FIG.", "11 illustrates an exemplary user interface for presenting vehicle information relating to an online on-demand service system according to some embodiments of the present disclosure.", "As shown in FIG.", "11, the user interface 1100 may include a map, a vehicle-shaped icon 1101, text information elements 1103-1 and 1103-2, a logo 1105, an image of a service provider 1107, a phone icon 1109 to call the service provider, a message icon 1111 to chat with the service provider, a location icon 1113 (e.g., a pickup point, a destination, etc.", "), or other user interface elements related to the online on-demand service system 100.At least one of the user interface elements in user interface 1100 may have a color that is same as or similar to the color of the vehicle.", "For example, the vehicle-shaped icon 1101 may be red if the vehicle is red.", "It should be noted that the user interface 1100 is provided for the purposes of illustration, and not intended to limit the scope of the present disclosure.", "The user interface may have any number of user interface elements and the user interface elements may be configured in any size, form, shape, and arrangement.", "Having thus described the basic concepts, it may be rather apparent to those skilled in the art after reading this detailed disclosure that the foregoing detailed disclosure is intended to be presented by way of example only and is not limiting.", "Various alterations, improvements, and modifications may occur and are intended to those skilled in the art, though not expressly stated herein.", "These alterations, improvements, and modifications are intended to be suggested by this disclosure, and are within the spirit and scope of the exemplary embodiments of this disclosure.", "Moreover, certain terminology has been used to describe embodiments of the present disclosure.", "For example, the terms “one embodiment,” “an embodiment,” and/or “some embodiments” mean that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment of the present disclosure.", "Therefore, it is emphasized and should be appreciated that two or more references to “an embodiment” or “one embodiment” or “an alternative embodiment” in various portions of this specification are not necessarily all referring to the same embodiment.", "Furthermore, the particular features, structures or characteristics may be combined as suitable in one or more embodiments of the present disclosure.", "Further, it will be appreciated by one skilled in the art, aspects of the present disclosure may be illustrated and described herein in any of a number of patentable classes or context including any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof.", "Accordingly, aspects of the present disclosure may be implemented entirely hardware, entirely software (including firmware, resident software, micro-code, etc.)", "or combining software and hardware implementation that may all generally be referred to herein as a “unit,” “module,” or “system.” Furthermore, aspects of the present disclosure may take the form of a computer program product embodied in one or more computer readable media having computer readable program code embodied thereon.", "A computer readable signal medium may include a propagated data signal with computer readable program code embodied therein, for example, in baseband or as part of a carrier wave.", "Such a propagated signal may take any of a variety of forms, including electro-magnetic, optical, or the like, or any suitable combination thereof.", "A computer readable signal medium may be any computer readable medium that is not a computer readable storage medium and that may communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device.", "Program code embodied on a computer readable signal medium may be transmitted using any appropriate medium, including wireless, wireline, optical fiber cable, RF, or the like, or any suitable combination of the foregoing.", "Computer program code for carrying out operations for aspects of the present disclosure may be written in any combination of one or more programming languages, including an object-oriented programming language such as Java, Scala, Smalltalk, Eiffel, JADE, Emerald, C++, C#, VB.", "NET, Python or the like, conventional procedural programming languages, such as the “C” programming language, Visual Basic, Fortran 2003, Perl, COBOL 2002, PHP, ABAP, dynamic programming languages such as Python, Ruby and Groovy, or other programming languages.", "The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server.", "In the latter scenario, the remote computer may be connected to the user's computer through any type of network, including a local area network (LAN) or a wide area network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet Service Provider) or in a cloud computing environment or offered as a service such as a Software as a Service (SaaS).", "Furthermore, the recited order of processing elements or sequences, or the use of numbers, letters, or other designations therefore, is not intended to limit the claimed processes and methods to any order except as may be specified in the claims.", "Although the above disclosure discusses through various examples what is currently considered to be a variety of useful embodiments of the disclosure, it is to be understood that such detail is solely for that purpose, and that the appended claims are not limited to the disclosed embodiments, but, on the contrary, are intended to cover modifications and equivalent arrangements that are within the spirit and scope of the disclosed embodiments.", "For example, although the implementation of various components described above may be embodied in a hardware device, it may also be implemented as a software only solution, e.g., an installation on an existing server or mobile device.", "Similarly, it should be appreciated that in the foregoing description of embodiments of the present disclosure, various features are sometimes grouped together in a single embodiment, figure, or description thereof for the purpose of streamlining the disclosure aiding in the understanding of one or more of the various embodiments.", "This method of disclosure, however, is not to be interpreted as reflecting an intention that the claimed subject matter requires more features than are expressly recited in each claim.", "Rather, claimed subject matter may lie in less than all features of a single foregoing disclosed embodiment." ] ]
Patent_15876092
[ [ "MANAGING DATA TRANSFERS OVER NETWORK CONNECTIONS BASED ON PRIORITY AND A DATA USAGE PLAN", "Embodiments manage use of different network connections for data transfer in view of priority information and a data usage plan identifying threshold limits associated with the different network connections.", "A computing device receives data transfer requests from applications executing on the computing device.", "The data transfer requests have priority information associated therewith.", "The computing device compares the priority information with available network connections.", "One or more of the data transfer requests are selected for initiation based on the comparison and on the threshold limits." ], [ "1.A system for managing use of network connections for data transfer, said system comprising: a memory area associated with a computing device, said memory area storing a plurality of data transfer requests received from at least one application of a plurality of applications executing on the computing device, the memory area further storing priority information associated with the plurality of data transfer requests; and a processor programmed to: compare the priority information stored in the memory area with a plurality of available network connections; select, from the received plurality of data transfer requests, a data transfer request identified as a high priority data transfer request for initiation over a first network connection of the plurality of network connections based on the comparison; notify the application associated with the selected data transfer request, the application initiating the selected data transfer request; detect an absence of the first network connection; determine that all other available network connections have data transfer costs that are greater than a data transfer cost associated with the first network connection; based on the determination that all other available network connections have data transfer costs that are greater than a data transfer cost associated with the first network connection, determine that none of the other available network connections should be used to initiate data transfer requests unless the data transfer requests are high priority; notify the application associated with the selected data transfer request of the detected absence; and based on notifying the application associated with the selected data transfer request of the detected absence, the application executes the selected data transfer request over one or more of the available network connections.", "2.The system of claim 1, wherein the selected data transfer request is operable with the first network connection and a second network connection, and wherein the application suspends performance of non-high priority data transfer requests in response to the notification to prevent performance of the non-high priority data transfer requests over the second network connection.", "3.The system of claim 2, wherein a data transfer cost associated with the second network connection is greater than the data transfer cost associated with the first network connection.", "4.The system of claim 1, wherein the memory area further stores a data usage plan describing threshold values associated with the first network connection.", "5.The system of claim 4, wherein the processor is programmed to select one or more of the received plurality of data transfer requests by selecting the one or more of the received plurality of data transfer requests by analyzing remaining data consumption based on the threshold values.", "6.The system of claim 1, wherein the processor is programmed to notify the application to reduce data transfer costs.", "7.The system of claim 1, wherein determining that no other available network connection should be used to initiate the data transfer requests unless the data transfer requests are high priority is based on the priority data.", "8.The system of claim 1, wherein determining that none of the other available network connection should be used to initiate the data transfer requests unless the data transfer requests are high priority is further based on a data usage plan associated with the computing device.", "9.A method comprising: receiving a plurality of data transfer requests from one or more applications executing on a first computing device, the plurality of data transfer requests having priority information associated therewith; after receiving the plurality of data transfer requests, determining an amount of data that has been transferred over a first network connection from the first computing device; comparing the priority information with the first network connection; and selecting one or more of the received plurality of data transfer requests that are identified as high priority data transfer requests for initiation over the first network connection based on the comparison and based on the determined amount of data transferred over the first network connection is greater than a maximum data threshold defined by a data usage plan.", "10.The method of claim 9, further comprising, for each of the received plurality of data transfer requests, determining the priority information to be one or more of the following: explicit, background, opportunistic, and predictive.", "11.The method of claim 9, further comprising receiving the priority information from the one or more applications for the plurality of data transfer requests.", "12.The method of claim 9, further comprising suspending all non-high priority data transfer requests of the received plurality of data transfer requests based on the determined amount of data transferred from the first computing device over the first network connection is greater than a maximum data threshold defined by a data usage plan.", "13.The method of claim 9, further comprising notifying the applications associated with the selected one or more of the received plurality of data transfer requests of the selecting, wherein the notified applications initiate the data transfer requests.", "14.The method of claim 9, wherein comparing further comprises comparing the tracked, cumulative amount of data to corresponding threshold values associated with the first network connection.", "15.The method of claim 14, wherein the data usage plan is associated with the first computing device and a second computing device.", "16.The method of claim 9, wherein the receiving, the comparing, and the selecting are performed by an operating system executing on the first computing device.", "17.One or more computer storage devices embodying computer-executable components, said components comprising: an interface component that when executed causes at least one processor to receive a plurality of data transfer requests from one or more applications executing on a first computing device the plurality of data transfer requests having priority information associated therewith; a type component that when executed causes at least one processor to classify one or more network connections available to the first computing device; a priority component that when executed causes at least one processor to assign one or more of the plurality of data transfer requests as high priority data transfer requests to the classified network connections based on the priority information and a remaining quantity of data available for consumption over the classified network connections, the remaining quantity of data available for consumption being determined from a data usage plan for the first computing device; and a notification component that when executed causes at least one processor to notify the applications of the assigned data transfer requests.", "18.The computer storage devices of claim 17, wherein a remaining quantity of data available for consumption being determined from a data usage plan shared between the first computing device and a second computing device is based on an accumulative amount of data sent and received by the first computing device and the second computing device.", "19.The computer storage devices of claim 17, wherein the priority component is further programmed to determine the remaining quantity of data available for consumption by comparing cumulative data consumption in a billing period with threshold values defined in the data usage plan.", "20.The computer storage devices of claim 17, wherein the priority component further sorts the network connections based on the classifications from the type component." ], [ "<SOH> BACKGROUND <EOH>With the increased popularity of smart telephones, tablets, and other mobile devices, there has been a similar increase in the amount of data handled by the networks of mobile operators.", "To reduce the strain on network infrastructure and to reduce network transfer costs, mobile operators are shifting from offering unlimited mobile data plans to offering capped and metered plans.", "With some of the capped and metered plans, the fees for exceeding the allotted data caps may be significant.", "While some existing web browsers attempt to optimize data traffic, the existing systems generally lack mechanisms for balancing specific needs of each user with data transfer costs.", "As a result, with the existing systems, users can unknowingly exceed the allotted data caps and experience bandwidth throttling (e.g., a reduction or limit placed upon the rate of consumption) and/or be presented with a much larger than normal monthly bill, resulting in “bill shock.” Throttling and bill shock can impact the user experience, leading to dissatisfied customers, increased customer service calls, and negative impressions of the mobile operators." ], [ "<SOH> SUMMARY <EOH>Embodiments of the disclosure manage use of network connections for data transfer.", "A first computing device receives a plurality of data transfer requests from one or more applications executing on the first computing device.", "Each of the plurality of data transfer requests has priority information associated therewith.", "The priority information is compared with one or more network connections between the first computing device and a second computing device.", "One or more of the received plurality of data transfer requests are selected for initiation based at least on the comparison and based on a data usage plan associated with a user of the first computing device.", "In other embodiments, the data transfer requests are selected for initiation based on other factors or considerations in addition to the priority information.", "This Summary is provided to introduce a selection of concepts in a simplified form that are further described below in the Detailed Description.", "This Summary is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used as an aid in determining the scope of the claimed subject matter." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. Non-Provisional application Ser.", "No.", "13/721,066, filed Dec. 20, 2012, which claims the benefit of pending U.S.", "Provisional Application No.", "61/696,472, filed Sep. 4, 2012, pending U.S.", "Provisional Application No.", "61/591,503, filed Jan. 27, 2012, and pending U.S.", "Provisional Application No.", "61/591,509, filed Jan. 27, 2012.The entireties of these applications are hereby incorporated by reference herein.", "This application is related to the following applications: U.S. patent application entitled “Tracking Data Usage Under a Schematized Data Usage Plan,” U.S. patent application entitled “On-Device Attribution of Network Data Usage,” U.S. patent application entitled “Predicting Network Data Consumption Relative to Data Usage Patterns,” U.S. patent application entitled “Updating Dynamic Data Usage Plans and Statistics,” U.S. patent application entitled “Data Usage Profiles for Users and Applications,” U.S. patent application entitled “Recommendations for Reducing Data Consumption Based on Data Usage Profiles,” U.S. patent application entitled “Dynamically Adjusting a Data Usage Plan Based on Data Usage Statistics,” and U.S. patent application entitled “Managing Network Data Transfers in View of Multiple Data Usage Plans.” All of these applications are incorporated by reference herein in their entirety.", "BACKGROUND With the increased popularity of smart telephones, tablets, and other mobile devices, there has been a similar increase in the amount of data handled by the networks of mobile operators.", "To reduce the strain on network infrastructure and to reduce network transfer costs, mobile operators are shifting from offering unlimited mobile data plans to offering capped and metered plans.", "With some of the capped and metered plans, the fees for exceeding the allotted data caps may be significant.", "While some existing web browsers attempt to optimize data traffic, the existing systems generally lack mechanisms for balancing specific needs of each user with data transfer costs.", "As a result, with the existing systems, users can unknowingly exceed the allotted data caps and experience bandwidth throttling (e.g., a reduction or limit placed upon the rate of consumption) and/or be presented with a much larger than normal monthly bill, resulting in “bill shock.” Throttling and bill shock can impact the user experience, leading to dissatisfied customers, increased customer service calls, and negative impressions of the mobile operators.", "SUMMARY Embodiments of the disclosure manage use of network connections for data transfer.", "A first computing device receives a plurality of data transfer requests from one or more applications executing on the first computing device.", "Each of the plurality of data transfer requests has priority information associated therewith.", "The priority information is compared with one or more network connections between the first computing device and a second computing device.", "One or more of the received plurality of data transfer requests are selected for initiation based at least on the comparison and based on a data usage plan associated with a user of the first computing device.", "In other embodiments, the data transfer requests are selected for initiation based on other factors or considerations in addition to the priority information.", "This Summary is provided to introduce a selection of concepts in a simplified form that are further described below in the Detailed Description.", "This Summary is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used as an aid in determining the scope of the claimed subject matter.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is an exemplary block diagram illustrating a computing device communicating with a plurality of other devices via one or more network connections.", "FIG.", "2 is an exemplary flow chart illustrating operation of the computing device to map data transfer requests to detected network connections based on priority information.", "FIG.", "3 is an exemplary sequence diagram illustrating notification of network connection availability for initiation of data transfer requests.", "FIG.", "4 is an exemplary graph illustrating data consumption compared to a data usage plan.", "Corresponding reference characters indicate corresponding parts throughout the drawings.", "DETAILED DESCRIPTION Referring to the figures, embodiments of the disclosure enable prioritizing of data transfer requests 112 to manage data consumption.", "In some embodiments, a service executing on a computing device 102 allows applications 110 to define priority information 114 for each of the data transfer requests 112.The service matches available network connections 132 to the data transfer requests 112 based on the priority information 114 and, in some embodiments, on data usage statistics 120 in view of a data usage plan 116.The data usage statistics 120 are used to determine whether a user and/or computing device 102 is under track, on track, or off track for usage compared to allotted usage under the data usage plan 116.For example, the data usage plan 116 may be associated with the user 104, computing device 102, a group of users 104, a group of computing devices 102, or any combination thereof.", "In some embodiments, the service notifies the selected applications 110 when the network connection 132 matching the requested priority information 114 is no longer available and/or when the data usage is predicted to exceed a billing period allotment.", "In response, the application 110 is able to halt data transfers to preserve data consumption for tasks with higher priority.", "Aspects of the disclosure further enable applications 110 to prioritize and balance data transfers based on user experience immediacy requirements.", "For example, the applications 110 may defer lower-priority operations to non-costed network connections 132.This enables the computing device 102 to differentiate urgency of traffic to minimize the amount of data transferred over any particular network type when the device is on a free Wi-Fi connection, pay-based Wi-Fi connection, tethered connection, cellular connection, multi-SIM devices, etc.", "Referring next to FIG.", "1, an exemplary block diagram illustrates the computing device 102 (e.g., a first computing device) communicating with one or more other devices 130 (e.g., second computing devices) via one or more network connections 132.In the example of FIG.", "1, the computing device 102 associated with the user 104 represents a system for managing use of network connections 132 for data transfer.", "The computing device 102 represents any device executing instructions (e.g., as application programs, operating system functionality, or both) to implement the operations and functionality associated with the computing device 102.The computing device 102 may include a mobile computing device or any other portable device.", "In some embodiments, the mobile computing device includes a mobile telephone, laptop, tablet, computing pad, netbook, gaming device, and/or portable media player.", "The computing device 102 may also include less portable devices such as desktop personal computers, kiosks, and tabletop devices.", "Additionally, the computing device 102 may represent a group of processing units or other computing devices.", "In some embodiments, the computing device 102 has at least one processor 106, a memory area 108, and at least one user interface (e.g., a touch screen or natural user interface).", "The processor 106 includes any quantity of processing units, and is programmed to execute computer-executable instructions for implementing aspects of the disclosure.", "The instructions may be performed by the processor 106 or by multiple processors executing within the computing device 102, or performed by a processor external to the computing device 102.In some embodiments, the processor 106 is programmed to execute instructions such as those illustrated in the figures (e.g., FIG.", "2).", "In some embodiments, the processor 106 represents an implementation of analog techniques to perform the operations described herein.", "For example, the operations may be performed by an analog computing device and/or a digital computing device.", "The computing device 102 further has one or more computer readable media such as the memory area 108.The memory area 108 includes any quantity of media associated with or accessible by the computing device 102.The memory area 108 may be internal to the computing device 102 (as shown in FIG.", "1), external to the computing device 102 (not shown), or both (not shown).", "In some embodiments, the memory area 108 includes read-only memory and/or memory wired into an analog computing device.", "The memory area 108 stores, among other data, one or more of the applications 110.The applications 110, when executed by the processor 106, operate to perform functionality on the computing device 102.Exemplary applications 110 include mail application programs, web browsers, calendar application programs, address book application programs, messaging programs, media applications, location-based services, search programs, and the like.", "The applications 110 may communicate with counterpart applications or services such as web services accessible via one or more networks.", "For example, the applications 110 may represent downloaded client-side applications that correspond to server-side services executing in a cloud.", "As another example, the applications 110 may send and receive data over one or more network connections 132 to other devices 130 or services.", "For example, the network connections 132 may include Wi-Fi, cellular, BLUETOOTH brand communication, near-field communication (NFC), and other types or configurations of one or more of the networks.", "The memory area 108 further stores a plurality of data transfer requests 112 received from one or more of the applications 110.The data transfer requests 112 represent requests by the applications 110 for use of at least one of the network connections 132.In some embodiments, each data transfer request 112 has priority information 114 associated therewith.", "The priority information 114 indicates a priority for association with the data transfer request 112, such as a level, degree, type, or other relative or absolute ordering information in a hierarchy of priorities.", "The priority information 114 for a particular data transfer request 112 may be provided by the application 110 providing the particular data transfer request 112.In other embodiments, the priority information 114 may be linked to characteristics or type of data transfer requests 112 or applications 110 providing the data transfer requests 112.For example, the priority information 114 associated with data transfer requests 112 from a mail application program may indicate a higher priority than priority information 114 associated with data transfer requests 112 from a social networking application program.", "Exemplary priority information 114 includes priorities such as Explicit, Background, Opportunistic, and Predictive, as described in Table 1 below.", "Aspects of the disclosure, however, are not limited to the following exemplary priorities or descriptions.", "TABLE 1 Exemplary Priority Information.", "Priority Description Priority Explicit user This priority is associated with a data 1 (P1) operation transfer request resulting from an action the user has taken, either directly through the user interface or via a settings page.", "The action may be a single or recurring operation that the user expects to be initiated, invoked, and/or completed based on time or event.", "The data transfer request is known or expected to consume data, and the data transfer request should not be deferred.", "Priority Background (e.g., This priority is associated with a data 2 (P2) explicit intent/ transfer request resulting from a user action implicit core that does not directly request to consume experience) data.", "If the data transfer request is not completed immediately, or at a specified time, the user experience will not be impacted negatively, but may lead to visible, noticeable, and/or perceptible differences in the user experience.", "Priority Opportunistic This priority is associated with a data 3 (P3) operation (e.g., transfer request that, if not completed at a deferred specified time, will not impact the user operation) experience negatively.", "The data transfer request may be scheduled when there is a low or very low risk of exceeding the threshold values under the data usage plan.", "Priority Predictive This priority is associated with a data 4 (P4) operation transfer request that does not have a specific target completion time, but should rather be performed upon detecting appropriate opportunities based on heuristics.", "An example of a P4 data transfer request may be sent by one of the applications 110 that determines that the user 104 is leaving for Vancouver soon (e.g., based on an analysis of an electronic calendar of the user 104).", "The application 110 generates the data transfer request with priority P4 to download relevant navigation map tiles opportunistically before the trip, such as while on a free or reduced cost connection (e.g., Wi-Fi rather than cellular).", "When the trip begins, the computing device 102 may then already have the navigation map tiles thereby reducing data usage on a cellular or roaming network connection 132.The memory area 108 further stores the data usage plan 116.The data usage plan 116 represents, for example, the mobile data plan agreement between the user and the mobile operator.", "The data usage plan 116 defines the usage limits associated with data transfer to/from the computing device 102, and/or usage limits associated with other devices of the user (e.g., mobile device, tablet, and laptop).", "The usage limits may also be associated with a group of users 104 or group of devices 102 (such as in a shared plan embodiment).", "In some embodiments, the data usage plan 116 describes threshold values 118 associated with at least one of the network connections 132.For example, the data usage plan 116 may indicate that two megabytes per month of data transfer over a digital cellular network connection 132 is available, while there is unlimited data transfer available over a Wi-Fi network connection 132.The computing device 102 monitors data transfer usage by the applications 110, and generates data usage statistics 120.The data usage statistics 120 represent an amount of network data consumed by the computing device 102 under the data usage plan.", "The data usage statistics 120 identify, to a granularity of time (e.g., per minute) or data (e.g., per kilobyte), how much data has been sent and/or received by the computing device 102, the time and date of usage (e.g., start and end times), the location of usage, network interface used (e.g., over which network connections), roaming state, data usage plan information, the subscriber identity module (SIM) or other user identity module used for dual SIM scenarios, the international mobile station equipment identity (IMEI) or other device identifier for multi-device scenarios, the Internet protocol (IP) address or other address of the access point used for Wi-Fi scenarios, the IP address or other address of a target computer (e.g., for whitelist/blacklists in data usage), the application responsible for the data transfer, and the like.", "In a further example, information relating to text messages, data, voice calls, minutes used, voice over Internet Protocol (VoIP) usage, and any other element of usage consumed by, or that impacts, the computing device 102 is collected to produce the data usage statistics 120.Other data usage statistics 120 are also contemplated.", "The memory area 108 further stores one or more computer-executable components.", "Exemplary components include an interface component 122, a type component 124, a priority component 126, and a notification component 128.Operation of these components, when executed, is described below with reference to FIG.", "2.Referring next to FIG.", "2, an exemplary flow chart illustrates operation of the computing device 102 to map data transfer requests 112 to detected network connections 132 based on priority information 114.While the operations illustrated in FIG.", "2 are performed by a mobile computing device in some embodiments, one or more of the operations may be performed by other devices, including any computing device local to, or remote from, the user 104.For example, the operations may be performed by a proxy device in communication with the mobile computing device.", "Further, in some embodiments, the operations illustrated in FIG.", "2 are performed by an operating system executing on the mobile computing device.", "At 202, the computing device 102 detects, or is informed of, available network connections 132 between the computing device 102 (e.g., a first computing device) and one or more other computing devices (e.g., second computing devices).", "For example, the computing device 102 may determine whether the network connection 132 has been established and/or has not expired.", "As another example, the computing device 102 may actually send a test packet (e.g., a ping) over each open network connection 132 to confirm the availability of each network connection 132.In some embodiments, the computing device 102 may further classify each of the detected network connections 132.For example, the network connections 132 may be classified according to type, speed, cost, and/or other factors or criteria.", "The computing device 102 accesses at least one of the data transfer requests 112 from the applications 110.For example, the computing device 102 may access the memory area 108 to retrieve or obtain the data transfer requests 112 that have been stored there by the applications 110, or the computing device 102 may receive the data transfer requests 112 from the applications 110 directly.", "The computing device 102 determines the priority information 114 associated with each of the data transfer requests 112.For example, the priority information 114 for one or more of the data transfer requests 112 may be specified by the requesting applications 110 or by a software vendor associated with the requesting applications 110.For those data transfer requests 112 lacking the priority information 114, the computing device 102 may assign default priority information 114.At 204, the priority information 114 for each of the accessed data transfer requests 112 is compared with the detected network connections 132 (and possibly the classifications associated therewith).", "In some embodiments, the priority information for one or more of the data transfer requests 112 includes a quality of service (QoS) requirement or request associated with the data transfer requests 112.The QoS requirements may be expressed by the applications 110.In some embodiments, other factors or considerations are contemplated.", "The other factors include a battery level (e.g., power remaining) for the computing device 102, which may be compared against the amount of power anticipated to be consumed by initiating the data transfer requests 112 over the network connections 132.At 206, the computing device 102 selects one or more of the accessed data transfer requests 112 for initiation based on the comparison, resulting in assignments between the one or more accessed data transfer requests 112 and the detected network connections 132.The relationship between the selected data transfer requests 112 and the network connections 132 may be stored, for example, in a file, table, database, or other data structure.", "In some embodiments, the computing device 102 attempts to match the requested priority information 114 with the available network connections 132.For example, using the exemplary priority information 114 described above in Table 1, priority P1 data transfer requests may be matched to any cellular or Wi-Fi network connections 132, priority P2 data transfer requests may be matched to any cellular or Wi-Fi network connections 132 when the computing device 102 is not roaming, priority P3 data transfer requests may be matched to any Wi-Fi network connections 132, and priority P4 data transfer requests may be matched only to free or otherwise non-costed Wi-Fi network connections 132.Selection of the accessed data transfer requests 112 may further include analyzing the data usage plan 116 associated with the user 104 and/or computing device 102.For example, the computing device 102 may track a cumulative amount of data transfers occurring over each of the network connections 132.The computing device 102 compares the tracked, cumulative amounts to the corresponding threshold values 118 associated with each of the network connections 132.Alternatively or in addition, the computing device 102 compares a projection of the tracked, cumulative amounts (e.g.", "associated with the end of the billing cycle) to the corresponding threshold values 118 associated with each of the network connections 132.The computing device 102 selects one or more of the data transfer requests 112 based on the comparison.", "For example, the computing device 102 determines whether the tracked, cumulative amounts of the available network connections 132 are less than the corresponding threshold values 118.If the computing device 102 determines that there is remaining data consumption available over particular, available network connections 132 (e.g., the cumulative amounts are less than the threshold values 118), the computing device 102 proceeds to match the data transfer requests 112 to those network connections 132.For the network connections 132 over which no further data consumption is available, the computing device 102 removes those network connections 132 from consideration when assignment data transfer requests 112 to network connections 132.The threshold values 118 may be obtained from the data usage plan 116.For example, the computing device 102 may correlate the detected network connections 132 with current consumption under the data usage plan 116 to determine which of the network connections 132 are available to the applications 110 as shown in Table 2 below.", "Table 2 below continues use of the example priorities provided in Table 1 above.", "TABLE 2 Exemplary Match Criteria for Relative Consumption Under Data Usage Plan.", "Priority Match Criteria Priority Explicit user For a data transfer request having priority 1 (P1) operation P1, match to any network connection when the user is Off Track, On Track, or Under Track Priority Background (e.g., For a data transfer request having priority 2 (P2) explicit intent/ P2, match to any network connection only implicit core when the user is On Track or Under Track, experience) or on an unlimited plan (e.g., no threshold values or limits).", "Priority Opportunistic For a data transfer request having priority 3 (P3) operation (e.g., P3, match to any network connection only deferred when the user is Under Track, or on an operation) unlimited plan (e.g., no threshold values or limits).", "Priority Predictive For a data transfer request having priority 4 (P4) operation P4, match to any network connection only when the user is on an unlimited plan (e.g., no threshold values or limits).", "If multiple network connections 132 are available, the computing device 102 may sort the network connections 132 when notifying the applications 110.For example, the network connections 132 may be sorted from free to expensive, and/or fast to slow.", "The computing device 102 initiates the selected data transfer requests 112 or may notify, at 208, the associated applications 110 of the selection to enable those applications 110 to initiate at least one of their corresponding, selected data transfer requests 112.After analyzing the network connections 132 at 202, the computing device 102 may conclude that one of the network connections 132 previously detected is no longer available, or is about to be no longer available.", "If the computing device 102 detects such an absence or anticipated absence of one or more of the previously detected network connections 132 at 210, the computing device 102 identifies the application(s) 110 that may be attempting to perform data transfers with the now-absent network connection 132.For example, the computing device 102 may analyze the previous mappings or assignments between data transfer requests 112 and network connections 132.At 212, the computing device 102 notifies those applications 110 of the detected absence of the network connections 132.In response, the notified applications 110 may suspend or postpone performance of their data transfer requests 112 over the now-absent, or soon-to-be-absent, network connections 132.The notified applications 110 may then initiate one or more of the suspended or postponed data transfers over a different network connection 132 that is available.", "For example, if the computing device 102 detects that a first network connection 132 is no longer available, the applications 110 may suspend performance over the first network connection 132 and resume or initiate performance over a second network connection 132.In embodiments in which a data transfer cost associated with the second network connection 132 is greater (or more expensive) than a data transfer cost associated with the first network connection 132, or based on the data usage statistics 120, the applications 110 (and/or the priority component 126) may choose to not use the second network connection 132.Instead, the applications 110 may attempt to prevent performance of the data transfer requests 112 over the second network connection 132 to prevent incurring higher network transfer costs for the user 104.In some embodiments, one or more of the operations illustrated in FIG.", "2 are performed by the computer-executable components illustrated in FIG.", "1.For example, the interface component 122, when executed by the processor 106 of the computing device 102, causes the processor 106 to receive a plurality of the data transfer requests 112 from one or more of the applications 110 executing on the computing device 102.The type component 124, when executed by the processor 106 of the computing device 102, causes the processor 106 to classify one or more of the network connections 132 detected between the computing device 102 and at least one other computing device.", "The priority component 126, when executed by the processor 106 of the computing device 102, causes the processor 106 to assign one or more of the data transfer requests 112 to the classified network connections 132 based on the priority information 114 and remaining bandwidth (e.g., remaining data consumption) associated with the classified network connections 132.The data consumption remaining may be determined from the data usage plan 116 and/or the data usage statistics 120.In some embodiments, the priority component 126 sorts the network connections 132 based on the classifications from the type component 124.The notification component 128, when executed by the processor 106 of the computing device 102, causes the processor 106 to notify the applications 110 of the assigned data transfer requests 112.Referring next to FIG.", "3, an exemplary sequence diagram illustrates notification of network connection 132 availability for initiation of the data transfer requests 112.One or more of the applications 110 register with an event scheduler 302, or other component executing on the computing device 102 for assignments between the data transfer requests 112 and the network connections 132.One or more of the registered applications 110 requests use of at least one of the network connections 132 to initiate a data transfer (e.g., send or receive).", "Those applications 110 may also provide the priority information 114 associated with the data transfer requests 112.A core networking component 304 executes on the computing device 102 to detect the network connections 132 available to the computing device 102.The core networking component 304 may analyze each of the network connections 132 continuously (e.g., without interruption) or continually (e.g., periodically), such as every minute.", "In other embodiments, the core networking component 304 analyzes each of the network connections 132 upon receiving a request for use of at least one of the network connections 132 from at least one of the applications 110.Further, the core networking component 304 may have different schedules for checking different network connections 132.For example, the core networking component 304 may check the availability of a Wi-Fi connection less frequently than the availability of a roaming cellular connection.", "In addition to checking the presence or absence of the networking connections, the core networking component 304 (or another component executing on the computing device 102) may check the data usage statistics 120 when determining whether a particular networking connection is available for use by the applications 110.If the user 104 and/or device has exceeded, or is about to exceed, the threshold values 118 for a particular network connection 132, the core networking component 304 may determine that the particular network connection 132 is not “available” to avoid incurring extra charges under the data usage plan 116.The core networking component 304 notifies the event scheduler 302 of the presence and/or absence of the network connections 132.Upon receipt of this notification, the event scheduler 302 maps or matches the queued data transfer requests 112 to the available network connections 132.For example, if the notification from the core networking component 304 indicates that a network connection 132 with priority X is available, the event scheduler 302 identifies the registered applications 110 that have sent or queued data transfer requests 112 having priority information 114 specifying priority X.", "Referring next to FIG.", "4, an exemplary graph illustrates data consumption compared to an exemplary data usage plan 116.In the example of FIG.", "4, the exemplary data usage plan 116 indicates that 200 megabytes (MB) is the threshold values 118 for a particular network connection 132 type (e.g., cellular) each month.", "Other threshold values 118 (e.g., other than 200 MB) and other billing periods (e.g., other than one month) are contemplated.", "The line in the graph in FIG.", "4 reflects the linear usage of the 200 MB over the course of the month.", "However, other data usage patterns such as non-linear patterns are also contemplated.", "In general, the shape of the usage curve is fit to, or otherwise dependent on, the pattern of the usage (e.g., the data usage pattern).", "For example, the data usage patterns may be based on the historical network data consumption of the user 104 and/or other users 104.The computing device 102 and/or the mobile operator track the data consumption by the user 104 and/or computing device 102 to generate the data usage statistics 120.The circles in the graph indicate the approximate areas where the user 104 and/or computing device 102 is Off Track (e.g., usage greater than the data usage pattern, the user 104 is on track to exceed 200 MB of data consumption before the end of the month), On Track (e.g., usage approximately equal to the data usage pattern, the user 104 is on track to consume 200 MB around the end of the month), and Under Track (e.g., usage less than the data usage pattern, the user 104 is not on track to consume the full 200 MB before the end of the month).", "In some embodiments, Off Track may be defined as the user 104 being on or above the projected limit (e.g., the value of the curve) given the day of the billing cycle and the current or up-to-date data consumption for the billing period.", "For example, given the day of the billing cycle and the current or up-to-date data consumption for the billing period, an extrapolation or projection is performed to predict the consumption associated with the end of the billing cycle.", "Similarly, On Track may be defined as the user 104 being at least 5% below the projected limit given the day of the billing cycle and the current or up-to-date data consumption for the billing period.", "Under Track may be defined as the user 104 being at least 20% below the projected limit given the day of the billing cycle and the current or up-to-date data consumption for the billing period.", "In some further embodiments, a notification is sent to the user 104 and/or applications 110 if the data usage is within 10% of the limit for a particular network connection 132 at any point during the billing period.", "The computing device 102 may then halt priority P3 data transfer requests using that network connection 132.Some embodiments contemplate an “Over Limit” category that allows users to opt out of data consumption by background transfers unless the background transfer are user-initiated or deemed critical.", "Additional Examples At least a portion of the functionality of the various elements in FIG.", "1 may be performed by other elements in FIG.", "1, or an entity (e.g., processor, web service, server, application program, computing device, etc.)", "not shown in FIG.", "1.In some embodiments, the operations illustrated in FIG.", "2 and FIG.", "3 may be implemented as software instructions encoded on a computer readable medium, in hardware programmed or designed to perform the operations, or both.", "For example, aspects of the disclosure may be implemented as a system on a chip or other circuitry including a plurality of interconnected, electrically conductive elements.", "The term “roaming” as used herein refers, in some embodiments, to connectivity provided outside a subscriber's home zone that may be subject to additional tariffs, fees, or constraints.", "Roaming service may or may not be provided by the same mobile operator 111.The term “tethered” as used herein refers, in some embodiments, to situations where one device acts as an access point for another device for network access.", "A tethered connection may occur over a wired connection or a wireless connection.", "The term “Wi-Fi” as used herein refers, in some embodiments, to a wireless local area network using high frequency radio signals for the transmission of data.", "The term “BLUETOOTH” as used herein refers, in some embodiments, to a wireless technology standard for exchanging data over short distances using short wavelength radio transmission.", "The term “cellular” as used herein refers, in some embodiments, to a wireless communication system using short-range radio stations that, when joined together, enable the transmission of data over a wide geographic area.", "The term “NFC” as used herein refers, in some embodiments, to a short-range high frequency wireless communication technology for the exchange of data over short distances.", "Embodiments have been described with reference to data monitored and/or collected from users 104.In some embodiments, notice may be provided to the users 104 of the collection of the data (e.g., via a dialog box or preference setting) and users 104 are given the opportunity to give or deny consent for the monitoring and/or collection.", "The consent may take the form of opt-in consent or opt-out consent.", "Exemplary Operating Environment Aspects of the disclosure are capable of operation and/or display on any computing device or screen.", "For example, the user 104 may move between a mobile device, a gaming console, an in-vehicle computing system (e.g., entertainment and/or navigation), a portable media player, and a laptop.", "Exemplary computer readable media include flash memory drives, digital versatile discs (DVDs), compact discs (CDs), floppy disks, and tape cassettes.", "By way of example and not limitation, computer readable media comprise computer storage media and communication media.", "Computer storage media include volatile and nonvolatile, removable and non-removable media implemented in any method or technology for storage of information such as computer readable instructions, data structures, program modules or other data.", "Computer storage media are tangible and are mutually exclusive to communication media.", "In some embodiments, computer storage media are implemented in hardware.", "Exemplary computer storage media include hard disks, flash drives, and other solid-state memory.", "In contrast, communication media typically embody computer readable instructions, data structures, program modules, or other data in a modulated data signal such as a carrier wave or other transport mechanism and include any information delivery media.", "Although described in connection with an exemplary computing system environment, embodiments of the disclosure are capable of implementation with numerous other general purpose or special purpose computing system environments, configurations, or devices.", "Examples of well-known computing systems, environments, and/or configurations that may be suitable for use with aspects of the invention include, but are not limited to, mobile computing devices, personal computers, server computers, hand-held or laptop devices, multiprocessor systems, gaming consoles, microprocessor-based systems, set top boxes, programmable consumer electronics, mobile telephones, network PCs, minicomputers, mainframe computers, distributed computing environments that include any of the above systems or devices, and the like.", "Such systems or devices may accept input from the user 104 in any way, including from input devices such as a keyboard or pointing device, via gesture input, and/or via voice input.", "Embodiments of the invention may be described in the general context of computer-executable instructions, such as program modules, executed by one or more computers or other devices.", "The computer-executable instructions may be organized into one or more computer-executable components or modules.", "Generally, program modules include, but are not limited to, routines, programs, objects, components, and data structures that perform particular tasks or implement particular abstract data types.", "Aspects of the invention may be implemented with any number and organization of such components or modules.", "For example, aspects of the invention are not limited to the specific computer-executable instructions or the specific components or modules illustrated in the figures and described herein.", "Other embodiments of the invention may include different computer-executable instructions or components having more or less functionality than illustrated and described herein.", "Aspects of the invention transform a general-purpose computer into a special-purpose computing device when configured to execute the instructions described herein.", "The embodiments illustrated and described herein as well as embodiments not specifically described herein but within the scope of aspects of the invention constitute exemplary means for reducing data transfer costs by opportunistic use of the network connections 132 based on the priority information 114.The order of execution or performance of the operations in embodiments of the invention illustrated and described herein is not essential, unless otherwise specified.", "That is, the operations may be performed in any order, unless otherwise specified, and embodiments of the invention may include additional or fewer operations than those disclosed herein.", "For example, it is contemplated that executing or performing a particular operation before, contemporaneously with, or after another operation is within the scope of aspects of the invention.", "When introducing elements of aspects of the invention or the embodiments thereof, the articles “a,” “an,” “the,” and “said” are intended to mean that there are one or more of the elements.", "The terms “comprising,” “including,” and “having” are intended to be inclusive and mean that there may be additional elements other than the listed elements.", "The term “exemplary” is intended to mean “an example of” The phrase “one or more of the following: A, B, and C” means “at least one of A and/or at least one of B and/or at least one of C.” Having described aspects of the invention in detail, it will be apparent that modifications and variations are possible without departing from the scope of aspects of the invention as defined in the appended claims.", "As various changes could be made in the above constructions, products, and methods without departing from the scope of aspects of the invention, it is intended that all matter contained in the above description and shown in the accompanying drawings shall be interpreted as illustrative and not in a limiting sense." ] ]
Patent_15876094
[ [ "Portable Intermediary Trusted Device", "In one embodiment, an intermediary gaming trusted electronic device for use with an untrusted PED may include a position sensor configured to acquire position information, a memory configured to store at least game session data, and a processor configured to at least: securely communicate with a gaming apparatus via the wireless transceiver; securely communicate with the associated untrusted PED; determine whether a gaming session is permitted based on the position information; receive gaming data from the gaming apparatus if it is determined that the gaming session is permitted; transmit presentation data to the associated untrusted PED for presentation on a display of the associated PED, wherein the intermediary gaming trusted device is able to support interaction between the gaming apparatus and the associated untrusted PED so that the associated untrusted PED, when coupled to the intermediary gaming trusted device, can execute a gaming software." ], [ "1.A portable intermediary gaming trusted device for use with an associated untrusted portable electronic device (FED), the device comprising: a position sensor configured to acquire position information of the associated untrusted PED; a memory configured to store at least game session data; a wireless transceiver; and a processor configured to at least: securely communicate with a gaming apparatus, the gaming apparatus able to receive or process a wager to play a game of chance; securely communicate with the associated untrusted PED; determine whether a gaming session for one or more games of chance is permitted based on the position information; receive gaming data from the gaming apparatus if it is determined that the gaming session is permitted; and enable the associated untrusted PED to display presentation data on a display of the associated untrusted PED, the presentation data being associated with the received gaming data, wherein the associated untrusted PED changes to a trusted device to display presentation data so long as the portable intermediary gaming trusted device is operatively coupled to the associated untrusted PED.", "2.A system for playing a wagering game of chance, the system supporting a portable electronic device (FED) having a display to display presentation data associated with gaming data based on the wagering game of chance, the system comprising: a portable intermediary gaming trusted device configured to securely communicate with the PED via a physical connection or a short-range wireless network; and a gaming server configured to securely communicate with the portable intermediary gaming trusted device to determine whether the PED is permitted to participate in a gaming session pertaining to a wager-based game of chance; and transmit gaming data to the PED so long as the PED is permitted to participate in the gaming session pertaining to a wager-based game of chance, wherein the portable intermediary gaming trusted device must remain at least periodically in communication with the gaming server in order for the PED to remain permitted to participate in the gaming session pertaining to a wager-based game of chance.", "3.A system for playing a wagering game of chance, the system supporting a portable electronic device (PED) having a display to display presentation data associated with gaming data based on the wagering game of chance, the system comprising: a portable intermediary gaming trusted device configured to securely communicate with the PED via a physical connection or a short-range wireless network; and a gaming apparatus configured to securely communicate with the portable intermediary gaming trusted device to determine whether the PED is permitted to participate in a gaming session pertaining to a wager-based game of chance; and transmit gaming data to the PED so long as the PED is permitted to participate in the gaming session pertaining to a wager-based game of chance, wherein the portable intermediary gaming trusted device must remain at least periodically in communication with the gaming apparatus in order for the PED to remain permitted to participate in the gaming session pertaining to a wager-based game of chance." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Gaming establishments continually try new methods to keep patrons in its establishment in order to increase profits.", "With more and more patrons using PEDs, mobile gaming is one way to increase profits.", "However, games of chance may not be played on unknown and untrusted PEDs." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>The accompanying drawings, which are incorporated into and constitute a part of this specification, illustrate one or more example embodiments and, together with the description of example embodiments, serve to explain the principles and implementations.", "In the drawings: FIG.", "1 illustrates an example block diagram of a network-based gaming system.", "FIGS.", "2A-2C illustrate example embodiments of an intermediary trusted gaming device.", "FIGS.", "3A and 3B illustrate example uses of the intermediary trusted gaming device.", "FIG.", "4 illustrates an example block diagram of an intermediary trusted gaming device.", "FIGS.", "5A and 5B illustrate example methods for playing games of chance using an intermediary gaming trusted device.", "FIG.", "6 illustrates an example method for playing a game of chance on a portable electronic device.", "FIG.", "7 illustrates an example method for playing a game of chance on a portable electronic device.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is continuation of U.S. patent application Ser.", "No.", "15/400,840, filed Jan. 6, 2017, and entitled “PORTABLE INTERMEDIARY TRUSTED DEVICE”, which is hereby incorporated herein by reference for all purposes, and which in turn is a continuation of U.S. patent application Ser.", "No.", "13/833,116, filed Mar.", "15, 2013, and entitled “PORTABLE INTERMEDIARY TRUSTED DEVICE”, which is hereby incorporated herein by reference for all purposes.", "This application is also related to U.S. application Ser.", "No.", "13/833,953 [Att.Dkt.No.", ": 902-P007], filed Mar.", "15, 2013, and entitled “GAMING DEVICE DOCKING STATION,” which is hereby incorporated by reference herein in its entirety for all purposes.", "BACKGROUND OF THE INVENTION Gaming establishments continually try new methods to keep patrons in its establishment in order to increase profits.", "With more and more patrons using PEDs, mobile gaming is one way to increase profits.", "However, games of chance may not be played on unknown and untrusted PEDs.", "OVERVIEW A network-based gaming system may support interaction between intermediary gaming trusted devices and PEDs and/or gaming machines so that games of chance are able to be securely presented to the user(s).", "The intermediary gaming trusted device is able to support a secure and controlled interaction between a gaming apparatus and an associated unknown, untrusted PED so that the associated untrusted PED, when coupled to the intermediary gaming trusted device, becomes a trusted PED and can execute gaming software.", "In one embodiment, an intermediary gaming trusted electronic device for use with an associated untrusted PED may include a position sensor configured to acquire position information of the untrusted PED, a memory configured to store at least game session data, a wireless transceiver, and a processor configured to at least: (i) securely communicate with a gaming apparatus via the wireless transceiver; (ii) securely communicate with the associated untrusted PED; (iii) determine whether a gaming session is permitted based on the position information; (iv) receive gaming data from the gaming apparatus if it is determined that the gaming session is permitted; and (v) transmit presentation data to the associated untrusted PED for presentation on a display of the associated PED, the presentation data associated with the received gaming data, wherein the intermediary gaming trusted device is able to support interaction between the gaming apparatus and the associated untrusted PED so that the associated untrusted PED, when coupled to the intermediary gaming trusted device, can execute a gaming software.", "In another embodiment, an intermediary gaming trusted device for use with an associated untrusted portable electronic device (PED), the device including a position sensor configured to acquire position information of the PED, a memory configured to store at least game session data, a wireless transceiver, and a processor configured to at least: (i) securely communicate with the gaming apparatus via the wireless transceiver; (ii) securely communicate with the associated untrusted PED; (iii) determine whether a gaming session is permitted based on the position information; (iv) receive gaming data from the gaming apparatus if it is determined that the gaming session is permitted; and (v) transmit presentation data to the associated untrusted PED for presentation on a display of the associated PED, the presentation data being associated with the received gaming data, wherein the associated untrusted PED can be trusted to display presentation data so long as the intermediary gaming trusted device is coupled thereto.", "In one embodiment, a system for playing a wagering game includes a portable electronic device (PED) having a display to display presentation data associated with gaming data, an intermediary gaming trusted device configured to securely communicate with the PED via a physical or wireless means, and a gaming apparatus configured to securely communicate with the intermediary gaming trusted device to transmit the gaming data to the intermediary gaming trusted device, wherein the intermediary gaming trusted device is configured to transmit the presentation data to the PED to allow a user of the PED to execute gaming software.", "The present invention provides other hardware configured to perform the methods of the invention, as well as software stored in a machine-readable medium (e.g., a tangible storage medium) to control devices to perform these methods.", "These and other features will be presented in more detail in the following detailed description of the invention and the associated figures.", "BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are incorporated into and constitute a part of this specification, illustrate one or more example embodiments and, together with the description of example embodiments, serve to explain the principles and implementations.", "In the drawings: FIG.", "1 illustrates an example block diagram of a network-based gaming system.", "FIGS.", "2A-2C illustrate example embodiments of an intermediary trusted gaming device.", "FIGS.", "3A and 3B illustrate example uses of the intermediary trusted gaming device.", "FIG.", "4 illustrates an example block diagram of an intermediary trusted gaming device.", "FIGS.", "5A and 5B illustrate example methods for playing games of chance using an intermediary gaming trusted device.", "FIG.", "6 illustrates an example method for playing a game of chance on a portable electronic device.", "FIG.", "7 illustrates an example method for playing a game of chance on a portable electronic device.", "DESCRIPTION OF EXAMPLE EMBODIMENTS The present disclosure relates generally to gaming systems.", "More particularly, the present disclosure relates to use of a portable electronic device (PED) in a gaming system and even more particularly use of a PED in a gaming system with an intermediary trusted device.", "Embodiments are described herein in the context of a portable intermediary trusted device.", "The following detailed description is illustrative only and is not intended to be in any way limiting.", "Other embodiments will readily suggest themselves to such skilled persons having the benefit of this disclosure.", "Reference will now be made in detail to implementations as illustrated in the accompanying drawings.", "The same reference indicators will be used throughout the drawings and the following detailed description to refer to the same or like parts.", "In the interest of clarity, not all of the routine features of the implementations described herein are shown and described.", "It will, of course, be appreciated that in the development of any such actual implementation, numerous implementation-specific decisions must be made in order to achieve the developer's specific goals, such as compliance with application- and business-related constraints, and that these specific goals will vary from one implementation to another and from one developer to another.", "Moreover, it will be appreciated that such a development effort might be complex and time-consuming, but would nevertheless be a routine undertaking of engineering for those of ordinary skill in the art having the benefit of this disclosure.", "In accordance with the present invention, the components, process steps, and/or data structures may be implemented using various types of operating systems, computing platforms, computer programs, and/or general purpose machines.", "In addition, those of ordinary skill in the art will recognize that devices of a less general purpose nature, such as hardwired devices, field programmable gate arrays (FPGAs), application specific integrated circuits (ASICs), or the like, may also be used without departing from the scope and spirit of the inventive concepts disclosed herein.", "FIG.", "1 illustrates an example block diagram of a network-based gaming system.", "The network-based gaming system 100 may support interaction between intermediary gaming trusted devices and one or more unknown, untrusted PEDs and/or gaming machines so that games of chance are able to be securely presented to the user(s).", "Initially, PEDs are untrusted devices and are supported or capable to play games of chance.", "However, once connected to an intermediary gaming trusted device, a PED becomes or is otherwise transformed into a trusted PED and is able to be used to execute gaming software.", "The network-based gaming system 100 may include at least one intermediary gaming trusted device 114a-n (where n is an integer).", "The intermediary gaming trusted device 114a-n may be associated with a PED 112a-n via a physical or wireless connection.", "Although each intermediary gaming trusted device is illustrated as connecting to one PED, the intermediary gaming trusted device may connect to more than one PED and thus acts as a trusted connection hub for multiple PED's.", "The PED 112a-n may be any portable device having a display such as, for example, portable telephones, laptops, computers, notebooks, tablets, media players, and the like.", "Wireless connections may be any known wireless methods such as a 3G wireless technology, 4G wireless technology, Bluetooth, wireless universal serial bus, near-field magnetic or communication sensor, Fire Wire, WiMax, IEEE 802.11x technology, radio frequency, narrow-beam infrared (IR) sensor, RFID tag, WiFi, vibration sensor or any other known wireless methods.", "Wired connections may be any known connection using a wire.", "The connection between the intermediary gaming trusted device and PED creates a secured pairing environment.", "Once paired, either a short-range (e.g.", "Bluetooth) or a long-range (e.g.", "WiFi) wireless communication tether (e.g.", "wireless leash) may be established and maintained during the wireless communication session.", "The intermediary gaming trusted device 114a-n may be configured to communicate with a gaming server 102 via a network 106 through a wired or wireless connection.", "In the same or another embodiment, the intermediary gaming trusted device 118 associated with the PED 120 may also be configured to communicate with a gaming machine 104 through a wired or wireless connection.", "The gaming machine 104 may then connect to the gaming server 102 via network 106 also through a wired or wireless connection.", "Wireless connections may be any known wireless methods such as a 3G wireless technology, 4G wireless technology, Bluetooth, wireless universal serial bus, near-field magnetic, Fire Wire, WiMax, IEEE 802.11 technology, radio frequency, or any other known wireless methods.", "Wired connections may be any known connection using a wire.", "The gaming server 102 may be configured to communicate with a player tracking server 108, location server 120, and an authentication server 116.The player tracking server 108 may communicate with a player tracking database 110 to obtain tracked player information such as player preferences, games of chance the player likes to play, entertainment the player enjoys, accumulated and used points, number of wins and losses, and any other similar player information.", "The authentication sever 116 may be used to authenticate and/or verify the player, the intermediary gaming trusted device 114a-n, 118, the PED 112a-n, 120, the gaming machine 104, or perform any other authentication or verification functions.", "Any known authentication method may be used, such as public-private key authentication algorithms, random number generators, authentication keys, location authentication, and the like.", "Each intermediary gaming trusted device 114a-n, 120 may be assigned to at least one PED 112a-n, 118.Although each intermediary gaming trusted device 114a-n, 118 is illustrated as being associated with one PED 112a-n, 120, this is not meant to be limiting as the intermediary gaming trusted device 114a-n, 118 may be assigned to more than one PED 112a-n, 120 and acts as a trusted gaming hub.", "Initially, PEDs are unknown and untrusted devices not capable of playing games of chance.", "However, once connected to an intermediary gaming trusted device, the PED becomes or is otherwise transformed into a trusted PED and is able to be used to play games of chance.", "Each intermediary gaming trusted device 114a-n, 118 may have a connector to connect to the PED 112a-n, 120.The connector is further illustrated and described in detail with reference to FIGS.", "2A-C and 3, however, example connectors may be a universal serial bus, male connector, wire, or any other connector able to connect the intermediary gaming trusted device 114a-n, 118 with the PED 112a-n, 120 to transmit and receive data.", "The intermediary gaming trusted device 114a-n, 118 may be configured to communicate with the authentication server 116.The intermediary gaming trusted device 114a-n, 118 may then, in turn, authenticate or verify the user of PED 112a-n, 120.The user of the PED 112a-n, 120 may be authenticated and/or verified though any known authentication and verification methods such as, for example, biometric verification (i.e.", "voice recognition, retinal scan, fingerprint verification, and the like), username, password, account number, and the like.", "Authentication of the user may also include authentication via a web-application associated with the gaming establishment and/or uploading authentication software from the intermediary gaming trusted device 114a-n, 118 to the PED 112a-n, 120.In another embodiment, the user of the PED 112a-n, 120 may also obtain the intermediary gaming trusted device 114a-n, 118 from a gaming establishment personnel.", "The gaming establishment personnel may then authenticate and/or verify the user as well as associate the intermediary gaming trusted device 114a-n, 118 to the PED 112a-n, 120.Once authenticated, the intermediary gaming trusted device 114a-n, 118 may receive gaming data from the gaming server 102.The gaming data may include gaming information or gaming establishment information.", "Gaming information may include, for example, player tracking information, gaming options, data to play a game of chance, funding information or options in order to play the games of chance, pay tables, and the like.", "The gaming establishment information may include, for example, advertisements (e.g.", "buffet coupons, movie trailers, and the like), tournament information, room booking information, entertainment information, and the like.", "The intermediary gaming trusted device 114a-n, 118 may control and review the communication between the PED and the gaming server 102.The intermediary gaming trusted device 114a-n, 118 may be configured to determine if the communication meets any desired rules or regulations.", "For example, if the user selects a “Cash Out” option on the PED 112a-n, 120 for $100,000.00, but the maximum amount to be cashed out is $2,000, the intermediary gaming trusted device 114a-n, 118 may prevent the user from cashing out.", "The intermediary gaming trusted device 114a-n, 118 may transmit the gaming data to the PED 114a-n, 120 or to the gaming machine 104.The intermediary gaming trusted device 114a-n, 118 may enable the PED 112a-n, 120 or the gaming machine 104 to display the gaming data.", "For example, if the gaming data is to play a game of chance, the game of chance may be displayed on a display of the PED 112a-n, 120 or the gaming machine 104.The game of chance may be, for example, poker, black jack, roulette, bingo, keno, video slot machine games, or any other game of chance.", "The intermediary gaming trusted device 114a-n, 118 may be configured to receive data from the PED 114a-n, 120 or the gaming machine 104 that is inputted by the user.", "The received data may then be transmitted from the intermediary gaming trusted device 114a-n, 118 to the gaming server 102 via the network 106 for processing.", "The received data may be transmitted to the gaming server 102 dynamically or periodically.", "In other words, the received data may be transmitted to the gaming server 102 dynamically or in real-time as it is received by the intermediary gaming trusted device 114a-n, 118.Alternatively, the received data may be buffered and transmitted to the gaming server 102 periodically such as every minute, ten (10) minutes, hour, or any other pre-defined time period.", "The gaming server 102 may then process and store the gaming data received from the intermediary gaming trusted device 114a-n, 118.The stored gaming data may be used in case of a power outage, weak or lost signals, or any other loss of gaming data.", "Once the received gaming data is processed, the gaming server 102 may transmit additional gaming data in response to the processed gaming data.", "The additional gaming data may be transmitted, in real-time on an as needed basis or in a bulk transfer mode for batch operations, to the intermediary gaming trusted device 114a-n, 118 for display on the PED 114a-n, 120 or the gaming machine 104 so that the player can continue to play the game of chance or receive additional gaming information.", "For instance, a video poker game on the gaming machine 104 may receive one card at a time, or five cards at a time, or ten cards at a time.", "In another example, a 5-reel slot game may receive one random number seed at a time, or 100 random number seeds for the next 20 games.", "Player input may include a selection of one of a plurality of games of chance, player preference options, selection of advertisement information, or the like.", "The gaming server 102 may be configured to determine the location of the intermediary gaming trusted device 114a-n, 118 using location server 120.Any known position or location methods may be used to determine the location of the intermediary gaming trusted device 114a-n, 118 such as cellular positioning, triangulation, global positioning systems, or any other location or positioning determining method.", "The position or location of the intermediary gaming trusted device 114a-n, 118 may be obtained periodically or at any pre-defined time period.", "For example, the intermediary gaming trusted device 114a-n, 118 may be pinged every thirty (30) seconds, minute, ten minutes, hour, or any periodic time interval for its location.", "A user may be prevented from playing a game or using the intermediary trusted gaming device 114a-n, 118 due to location, time, establishment rules, government rules, or any other restrictions the gaming establishment may have or impose.", "For example, if the user decides to leave the gaming establishment and the location server 120 determines that the intermediary gaming trusted device 114a-n, 118 is outside the gaming establishment, the gaming server 102 may cause to the intermediary gaming trusted device to cease performing any gaming activities.", "In another embodiment, if the intermediary trusted gaming device 114a-n, 118 is in a restricted location such as the kids club, the intermediary trusted gaming device 114a-n may cease performing any gaming activities.", "In still another example, if the player has played or lost a certain amount of money, the intermediary trusted gaming device 114a-n may cease performing any gaming activities.", "FIGS.", "2A-3C illustrate example embodiments of an intermediary trusted gaming device.", "The intermediary trusted gaming device may be a portable electronic device that a user may carry around.", "The intermediary trusted gaming device may be any size, but is preferably sized to fit in a pocket, purse, or the like.", "FIG.", "2A illustrates one example of an intermediary trusted gaming device.", "The intermediary trusted gaming device 200 may include a housing 210.The housing 210 may have at least a status indicator, such as one light emitting diode (LED) 204.The LED 204 may be any color and any shape.", "The LED 204 may be configured to turn on or off to inform the user of its activities.", "For example, a green LED 204 may inform the user that the intermediary trusted gaming device 200 is properly connected to a PED, such as PED 112a-n, 118 illustrated in FIG.", "1.In another example, a red LED 204 may inform the user that the intermediary trusted gaming device 200 is low on battery or is not properly connected to the PED, such as PED 112a-n, 118 illustrated in FIG.", "1.In still another example, the LED 204 may flash to inform the user that the intermediary trusted gaming device 200 is receiving information either from the PED and/or gaming server, such as gaming server 102 illustrated in FIG.", "1.Although the LED 204 is illustrated as being positioned on side 212 of the intermediary trusted gaming device 200, this is not intended to be limiting as the LED 204 may located anywhere on housing 210.Although the status indicator is described as a simple LED indicator, it maybe implemented as a LCD display for user-friendly text or graphical information.", "Intermediary trusted gaming device 200 may have connector 206 configured to connect to a PED, such as PED 112a-n, 118 illustrated in FIG.", "1.Connector 206 may be configured to receive or transmit signals or data from/to the PED.", "As illustrated, connector 206 may be a USB connector.", "Although illustrated as being positioned on side 202 of the intermediary trusted gaming device 200, this is not intended to be limiting as the connector 206 may located anywhere on housing 210.FIG.", "2B illustrates another example intermediary trusted gaming device.", "The intermediary trusted gaming device 220 may include a housing 230, display 224, microphone 228, buttons 226a-n, and connector 222.Connector 222, similar to connector 206 illustrated in FIG.", "2A, may be configured to connect to a PED.", "Display 224 positioned on the housing may be used to display any desired information.", "For example, the display may display a request for a username and/or password, inform the user that the intermediary trusted gaming device 220 is properly connected to the PED, such as PED 112a-n, 118 illustrated in FIG.", "1, or any other desired information.", "In one embodiment, display 224 may be a projector.", "For example, if the image on the display of the PED is too small, the player may want to view a larger image to play the game of chance.", "The display may be configured to project the game of chance in a larger image and allow the player to play the game of chance.", "The image may be projected on a table, wall, or any other surface or non-surface.", "The microphone 228 may be configured to receive audio input, such as, for example, voice input.", "For example, if the user is unable to input his password on the PED, for any reason, the user may speak his password into the microphone.", "In another example, the microphone 228 may be used to receive the user's voice to authenticate the user.", "Instead of the microphone 228, other biometric sensors such as a camera or a fingerprint sensor may also be used for authenticating the user of the PED.", "Buttons 226a-n may be used for any desired purpose or reason.", "For example, buttons 226a-n may be used to turn the intermediary trusted gaming device 220 on or off.", "In another example, button 226a-n may be used to signal a gaming establishment personnel that the player would like to order a drink.", "In another embodiment, buttons 226a-n maybe a numeric keypad, or an alphanumeric keypad, or a directional keypad, and the like.", "FIG.", "2C illustrates still another example of an intermediary trusted gaming device.", "Intermediary trusted gaming device 240 is similar to intermediary trusted gaming device 220 illustrated in FIG.", "2B, except that intermediary trusted gaming device 240 includes a camera 244.Camera 244 may be used for any desired purpose or reason.", "For example, camera 244 may be used to authenticate the player (e.g.", "facial recognition, compare a picture of the player stored in the player tracking database to a picture taken by the intermediary trusted gaming device 240, and the like).", "In another example, camera 244 may be used to allow a player to take a picture for upload to the player's player tracking account.", "In still another example, camera 244 may be configured to recognize player gestures to allow the player to play the games of chance as opposed to using the PED to input data.", "Although intermediary trusted gaming device 200, 220, 240 is illustrated as having a rectangular shape, this is for illustrating purposes and is not intended to be limiting.", "Intermediary trusted gaming device 200, 220, 240 may be formed of any desired shape such as a circle, triangle, star, shape of the gaming establishment's logo, and the like.", "Additionally, indicia may be printed anywhere on the housing of intermediary trusted gaming device 200, 220, 240.For example, the intermediary trusted gaming device 200, 220, 240 may be personalized for the player.", "In another example, the intermediary trusted gaming device 200, 220, 240 may include indicia of any sponsor, the gaming establishment, or any other desired indicia.", "FIGS.", "3A and 3B illustrate example uses of the intermediary trusted gaming device.", "Referring to FIG.", "3A, the intermediary trusted gaming device 310 may have a connector 306 configured to connect into any input/output (I/O) port 308 of the PED 300 via arrow A.", "When connected properly, PED 300 may have a display 302 to display gaming data received from the intermediary trusted gaming device 310.Although illustrated with the use of a connector 306, this is for illustrative purposes only and not meant to be limiting as the intermediary trusted gaming device 310 may also be configured to communicate with the PED 300 via any known wireless methods.", "In other words, intermediary trusted gaming device 310 need not be physically connected to the PED 300 to communicate with the PED 300.Referring now to FIG.", "3B, intermediary trusted gaming device 310 may connect to a gaming machine 320.In one embodiment, intermediary trusted gaming device 310 may be coupled to a PED 300 and be configured to communicate with the gaming device 310 wirelessly.", "For example, the player may want to play the game of chance at the sports bar while watching a basketball game.", "However, after the basketball game ends, the player may then want to sit and continue to play the game of chance on gaming machine 320.In another embodiment, intermediary trusted gaming device 310 may be coupled to the gaming machine 320 itself at I/O port 324.For example, the PED 300 may be low on batteries but the player would like to continue to play his game of chance.", "Thus, the intermediary trusted gaming device 310 may be coupled to the gaming machine 320 at I/O port 324.Although the I/O port is illustrated on housing 326 of gaming machine 320, this is for illustrative purposes only and not meant to be limiting.", "For example, I/O port 324 may also be positioned on a player tracking device 322 or in any other position on housing 326.Whether connected to the PED 300 or gaming machine 320, intermediary trusted gaming device 310 may transmit or receive gaming data to or from gaming server 325 via any known wireless methods.", "If the intermediary trusted gaming device 310 is connected to the PED 300, the gaming data may be displayed on display 302 of the PED 300.If the intermediary trusted gaming device 310 is connected to the gaming machine 320, the gaming data may be displayed on display 328 or secondary display 330.FIG.", "4 illustrates an example block diagram of an intermediary trusted gaming device.", "The intermediary trusted gaming device 400 may have a processor 402 configured to communicate with connector 404.Processor 402 may be configured to receive and transmit gaming information via connector 404 from and to the PED.", "Processor 402 may also be configured to communicate with a camera 408, microphone 410, LED 416, display 414, and buttons or switches 420.As stated above with reference to FIG.", "2B, camera 408 may be used to authenticate or verify the user.", "Once a picture of the player is taken using camera 408, processor 402 may process the picture to authenticate or verify the player.", "Additionally, processor 402 may process the input associated with selected buttons 420 or display the desired message or indicia on display 414.As stated above with reference to FIG.", "2C, microphone 410 may also be used to authenticate or verify the user.", "Once the player's voice is captured by the intermediary trusted gaming device 400 via microphone 410, processor 402 may process the player's voice to authenticate or verify the player.", "Additionally, processor 402 may be configured to control LED 416 as described above with reference to FIG.", "2A.", "Intermediary trusted gaming device 400 may also have at least one transceiver 412.In one embodiment, the intermediary trusted gaming device 400 may have a long-range transceiver, short-range transceiver, or both.", "The transceiver 412 may be designed to locate the position of the intermediary trusted gaming device 400 through use of any known positioning methods as discussed in detail above.", "As stated above, intermediary trusted gaming device 400 may communicate wirelessly and therefore may have a wireless sensor 422.Intermediary trusted gaming device 400 may have at least one memory 406.The memory 406 may be any type of memory configured to store gaming applications, game logic, game session data, authentication software, and the like.", "For example, the memory may be a non-volatile random access memory (NVRAM), flash memory, dynamic random access memory (“DRAM”)), and the like.", "The intermediary trusted gaming device 400 may have a power source 424.The power source 424 may be any known power source such as a battery and may be powered through any known means.", "For example, the power source 424 may be powered when physically connected to a PED or plugged into a power outlet.", "When the power source 424 is an internal battery, it maybe recharged when connected to an external power source such as a power outlet.", "Having an internal battery onboard the intermediary trusted device 400 may maintain communication to another device in the network such as a location server or a game server even when the PED is not powered on.", "In one embodiment, the intermediary trusted device 400's connection to the location server persists so that its location can be accounted for at all time.", "In one embodiment, intermediary trusted gaming device 400 may also have a cryptographic module 418 to decrypt communication received from a gaming server and/or PED and to encrypt communication transmitted to the PED and/or gaming server.", "FIGS.", "5A and 5B illustrate example methods for playing games of chance using an intermediary gaming trusted device.", "Referring to FIG.", "5A, the method 500 initially begins with associating an intermediary gaming trusted device with an untrusted PED at 502.The association may occur through any known association methods.", "For example, the gaming establishment personnel may manually associate the intermediary gaming trusted device with the untrusted PED.", "In another example, the intermediary gaming trusted device may be physically coupled to the untrusted PED.", "The associated untrusted PED may be detected at 504 by the intermediary gaming trusted device.", "If physically coupled to the untrusted PED, detection of the untrusted PED may occur when the intermediary gaming trusted device is coupled to the PED via the connector of the intermediary gaming trusted device.", "If communication of the untrusted PED is wireless, detection may occur when the intermediary gaming trusted device connects wirelessly with the untrusted PED.", "A determination of whether the user of the untrusted PED is authenticated is made at 506.If the user is not authenticated, the method 500 may end.", "Authentication and/or verification of the user may be through any known authentication and verification methods such as, for example, biometric verification (i.e.", "voice recognition, retinal scan, fingerprint verification, and the like), username, password, account number, and the like.", "Authentication of the user may also include authentication via a web-application associated with the gaming establishment and/or uploading authentication software from the intermediary gaming trusted device to the untrusted PED.", "In another embodiment, the user of the untrusted PED may also obtain the intermediary gaming trusted device from a gaming establishment personnel.", "The gaming establishment personnel may then authenticate and/or verify the user as well as associate the intermediary gaming trusted device to the untrusted PED.", "If the user of the untrusted PED is authenticated, the intermediary gaming trusted device may be authenticated at 508.If the intermediary gaming trusted device is not authenticated, the method 500 may end.", "Authentication of the intermediary gaming trusted device may be made by any known means.", "For example, a unique identifier of the intermediary gaming trusted device may be compared to identifiers stored at a gaming server.", "In one embodiment, the intermediary gaming trusted device may automatically connect to the gaming server and authenticate itself when turned on or powered up.", "If the intermediary gaming trusted device is authenticated at 508, the intermediary gaming trusted device may receive gaming data at 510 from a gaming server.", "The gaming data may include a plurality of options.", "The gaming data may include gaming information or gaming establishment information.", "Gaming information may include, for example, player tracking information, gaming options, data to play a game of chance, funding information or options in order to play the games of chance, pay tables, and the like.", "The gaming establishment information may include, for example, advertisements (e.g.", "buffet coupons, movie trailers, and the like), tournament information, room booking information, entertainment information, and the like.", "The untrusted PED becomes or is otherwise transformed into a trusted PED and the gaming data may then be transmitted to the associated trusted PED.", "As stated above, the gaming data may include a plurality of gaming options, such as, for example, a list of games of chance the user may select to play.", "The games of chance may be any game of chance such as blackjack, poker, roulette, craps, bingo, keno, video slot machines, and the like.", "Each list may also include a logo or any other indicia with each option, a summary of what the option is, a number of times the player has played each game of chance, the last time the selection was made by the player, or any other desired information.", "A selection of one of the gaming options may be detected at 514.For example, the player may want and select to play a game of black jack.", "In one embodiment, selection of one of the gaming options may be executed by the user on the trusted PED.", "In another embodiment, selection of one of the gaming options may be selected on the intermediary gaming trusted device.", "Once a selection has been made, the intermediary gaming trusted device may transmit the selected gaming option to the gaming server at 516.Referring now to FIG.", "5B, gaming data associated with the selected gaming option may be received at 518 by the intermediary gaming trusted device.", "For example, gaming data to play black jack may be received if the black jack option was selected.", "The gaming data may then be transmitted to the associated trusted PED for display on a display of the associated trusted PED at 520.Once displayed, any input associated with the displayed data may be detected at 522.For example, if the data displayed was to play a game of chance, inputs associated with playing the game of chance may be detected such as a wagering amount, spin, hold, and the like.", "In another example, if the data displayed was a poker tournament, the input may be to register for the tournament.", "In still another example, if the displayed data was a coupon to the buffet, the input may be to add the coupon to the player tracking account, print the coupon, or a cancel the coupon.", "The user input may be detected from the PED or the intermediary gaming trusted device.", "If the displayed data was to play a game of chance, the gaming session data may be generated at 524.In one embodiment, the intermediary gaming trusted device may generate the gaming session data at 524.For instance, the number of games played, by whom, where and when, and the aggregate amount of wager since the start of the game session maybe calculated and recorded by the intermediary gaming trusted device.", "In still another embodiment, the gaming session data may be generated from the gaming server and transmitted to the intermediary gaming trusted device.", "For instance, a random bonus amount and the associated triggering event maybe generated by the gaming server and sent to the intermediary gaming trusted device.", "In yet another embodiment, the gaming session data maybe generated from the user's inputs at the PED during the gaming session.", "Gaming session data may include any information the user inputs while playing a game, number of wins or losses, amount of funds remaining or added, clicking on advertisements, and any other gaming information generated during the game session.", "The gaming session data may be stored at 526.The gaming session data may be stored on the intermediary gaming trusted device periodically or dynamically in real-time.", "For example, the gaming session data may be stored or saved at predefined intervals such as every minute, every hour, every ten (10) seconds, and the like.", "In another example, the gaming session data may be stored dynamically as the gaming session data is generated.", "The gaming session data may be transmitted to the gaming server at 528.The gaming session data may be transmitted to the gaming server periodically or dynamically in real-time.", "For example, the gaming session data may be buffered and transmitted at predefined intervals such as every minute, every hour, every ten (10) seconds, and the like.", "In another example, the gaming session data may be transmitted dynamically in real-time as the gaming session data is generated.", "A determination of whether the gaming session is still permitted is made at 530.Gaming sessions may be permitted based on various factors such as location of the intermediary gaming trusted device, duration of play, time of day, user information, gaming regulations, amount played, and the like.", "For example, if the intermediary gaming trusted device is determined to be in the parking lot where playing games of chance are not permitted, the gaming session will end and the intermediary gaming trusted device may cease to perform any gaming activities.", "In another example, if gaming regulations prohibit game play after the loss of $500 within a 24-hr period, the gaming session will end and the intermediary gaming trusted device may cease to perform any gaming activities.", "If the gaming session is permitted at 530, a determination of whether gaming information is requested is made at 532.If a request for gaming information is detected at 532, the intermediary gaming trusted device may transmit the request to the gaming server and the method 500 may continue at step 512 of FIG.", "5A.", "If a request for gaming information is not detected or not permitted at 532, a determination of whether the gaming session ends is made at 534.For example, if a cash-out input was detected, the gaming session may end.", "In another example, if the PED has been determined to have been moved out of the allowed area, the gaming session may also end.", "In yet another example, if there are no credits to play the game of chance, the gaming session may end.", "If the gaming session did not end at 534, the method may continue at step 522.If the gaming session is determined to end at 534, the gaming session data may be transmitted to the gaming server at 536.Once the gaming session data is transmitted to the gaming server at 536, all gaming session data, gaming data, gaming software, and any other gaming related information and data are deleted from the associated trusted PED at 538.All gaming related information and data are deleted from the associated trusted PED to prevent fraud, hacking, and the like.", "FIG.", "6 illustrates an example method for playing a game of chance on a portable electronic device.", "The PED may be connected to an intermediary gaming trusted device to convert or otherwise transform an untrusted PED to a trusted PED to play games of chance and/or receive gaming related information.", "The method 600 initially begins with detection of the intermediary gaming trusted electronic device at 602.If physically coupled to the untrusted PED, detection of the intermediary gaming trusted device occurs when it is coupled to the PED via a connector, wire, or any other means.", "If communication with the intermediary gaming trusted device is wireless, detection may occur when the untrusted PED connects wirelessly with the intermediary gaming trusted device.", "An authentication and/or verification request may be received at 604.The untrusted PED may receive the authentication request form detected intermediary gaming trusted electronic device.", "Authentication and/or verification of the user may be through any known authentication and verification methods such as, for example, biometric verification (i.e.", "voice recognition, retinal scan, fingerprint verification, and the like), username, password, account number, and the like.", "Authentication of the user may also include authentication via a web-application associated with the gaming establishment and/or uploading authentication software from the intermediary gaming trusted device to the untrusted PED.", "In another embodiment, the user of the untrusted PED may also obtain the intermediary gaming trusted device from a gaming establishment personnel.", "The gaming establishment personnel may then authenticate and/or verify the user as well as associate the intermediary gaming trusted device to the untrusted PED.", "In still another embodiment, the authentication request may require the untrusted PED to download software or an authentication application.", "The software may request the user of the untrusted PED to input authentication and/or verification information to authenticate and/or verify the user.", "If the untrusted PED is not authenticated at 606, the intermediary gaming trusted device will cease to perform any tasks and the method 600 may end.", "If the untrusted PED is authenticated at 606, the untrusted PED then becomes or is otherwise converted to a trusted PED.", "The trusted PED may then receive gaming data from the intermediary gaming trusted electronic device at 608.The gaming data may have a plurality of gaming options.", "The gaming data may include gaming information or gaming establishment information.", "Gaming information may include, for example, player tracking information, gaming options, data to play a game of chance, funding information or options in order to play the games of chance, pay tables, and the like.", "The gaming establishment information may include, for example, advertisements (e.g.", "buffet coupons, movie trailers, and the like), tournament information, room booking information, entertainment information, and the like.", "The gaming options may include a list of games of chance the player may like to play such as, blackjack, poker, video slot machines, video games, keno, and the like.", "Each list may also include a logo or any other indicia with each option, a summary of what the option is, a number of times the player has played each game of chance, the last time the selection was made by the player, or any other desired information.", "The gaming data may then be displayed on a display of the trusted PED at 610.The user of the trusted PED may select an option associated with the displayed gaming data which is then transmitted to the intermediary gaming trusted device at 612.The selection may be made using the trusted PED and/or the intermediary gaming trusted device.", "For example, if the gaming data was a list of games of chance the play may play, the list may be displayed on the display of the trusted PED and the use may select one of the games of chance to play.", "The selected game of chance may be transmitted to the intermediary gaming trusted device.", "In another example, if the gaming data was a coupon for the buffet, the option may be to accept or decline the coupon which the user may select.", "The selection may then be transmitted to the intermediary gaming trusted device.", "If the user selected a game of chance to play using the trusted PED, gaming data may be received at 614 to start a gaming session for the player.", "The gaming data may be associated with the selected game of chance.", "For example, gaming data to play black jack may be received if the black jack option was selected.", "The gaming data may then be transmitted to the associated trusted PED for display on a display of the associated trusted PED at 616.Once displayed, any input associated with the displayed gaming data may be detected and transmitted to the intermediary gaming trusted device at 618.For example, if the data displayed was to play a game of chance, inputs associated with playing the game of chance may be detected such as a wagering amount, spin, hold, and the like.", "In another example, if the data displayed was a poker tournament, the input may be to register for the tournament.", "In still another example, if the displayed data was a coupon to the buffet, the input may be to add the coupon to the player tracking account, print the coupon, or a cancel the coupon.", "The user input may be detected from the PED or the intermediary gaming trusted device.", "A determination of whether the gaming session is permitted is made at 620.Gaming sessions may be permitted based on various factors such as location of the intermediary gaming trusted device, duration of play, time of day, user information, gaming regulations, amount played, and the like.", "For example, if the intermediary gaming trusted device is determined to be in the parking lot where playing games of chance are not permitted, the gaming session will end and the intermediary gaming trusted device may cease to perform any gaming activities.", "In another example, if gaming regulations prohibit game play after the loss of $500 within a 24-hr period, the gaming session will end and the intermediary gaming trusted device may cease to perform any gaming activities.", "If the gaming session is permitted at 620, a determination of whether the gaming session should end is made at 622.For example, if a cash-out input was detected, the gaming session may end.", "In another example, if the PED has been determined to have been moved out of the allowed area, the gaming session may also end.", "In yet another example, if there are no credits to play the game of chance, the gaming session may end.", "If the gaming session did not end at 622, the method may continue at step 608.If the gaming session is determined to end at 622, the gaming session data may be transmitted to the intermediary gaming trusted device at 624.Once the gaming session data is transmitted to the intermediary gaming trusted device at 624, all gaming session data, gaming data, gaming software, and any other gaming related information and data are deleted from the associated trusted PED at 626.All gaming related information and data are deleted from the associated trusted PED to prevent fraud, hacking, and the like.", "FIG.", "7 illustrates an example method for playing a game of chance on a portable electronic device.", "The PED may be configured to communicate with an intermediary gaming trusted device which is configured to communicate with a server.", "Use of the intermediary gaming trusted device converts an unknown and untrusted PED to a trusted PED to create a controlled and secure environment where a player may play games of chance or obtain gaming data.", "The method 700 initially begins when a gaming server receives an authentication request from the intermediary gaming trusted device at 702.The request may be to authenticate the unknown and untrusted PED and/or authenticate the intermediary gaming trusted device.", "If neither the untrusted PED and/or intermediary gaming trusted device are authenticated at 704, the method 700 may end.", "Authentication and/or verification of the untrusted PED may be through any known authentication and verification methods such as, for example, biometric verification (i.e.", "voice recognition, retinal scan, fingerprint verification, and the like) of the user, username, password, account number, device identifier, digital signature of the operating system and/or the software application, and the like.", "Authentication of the untrusted PED may also include authentication via a web-application associated with the gaming establishment and/or uploading authentication software from the intermediary gaming trusted device to the untrusted PED.", "The information received by the gaming server may be authenticated with information stored in a database, such as, for example, a player tracking base 110 illustrated in FIG.", "1.Similarly, the intermediary gaming trusted device may have a unique identifier that may be compared to identifiers stored at the gaming server.", "Once authenticated at 704, gaming data may be sent to the intermediary gaming trusted device at 706.The gaming data may include gaming information or gaming establishment information.", "Gaming information may include, for example, player tracking information, gaming options, data to play a game of chance, funding information or options in order to play the games of chance, pay tables, and the like.", "The gaming establishment information may include, for example, advertisements (e.g.", "buffet coupons, movie trailers, and the like), tournament information, room booking information, entertainment information, and the like.", "The gaming data may include a plurality of gaming options, such as, for example, a list of games of chance the user may select to play.", "The games of chance may be any game of chance such as blackjack, poker, roulette, craps, sicbo, bingo, keno, video slot machines, and the like.", "Each list may also include a logo or any other indicia with each option, a summary of what the option is, a number of times the player has played each game of chance, the last time the selection was made by the player, or any other desired information.", "A selected gaming option may be received at 708 from the intermediary gaming trusted device.", "Gaming data associated with the received selected gaming option may be transmitted at 710 to the intermediary gaming trusted device.", "For example, if the received selected gaming option is to play black jack, the transmitted gaming data may be associated with black jack.", "In another example, if the selected gaming option is to obtain movie tickets, the gaming data may be a list of movies playing at the theater.", "The gaming server may periodically or dynamically receive gaming session data at 712 from the intermediary gaming trusted device.", "Gaming session data may be any session data resulting from playing a game of chance such as number of wins or losses, amount of funds remaining or added, clicking on advertisements, and any other gaming information generated during the game session.", "The gaming session data may be received periodically or dynamically in real-time.", "For example, the gaming session data may be received at predefined intervals such as every minute, every hour, every ten (10) seconds, and the like.", "In another example, the gaming session data may be received dynamically in real-time as the gaming session data is generated.", "A determination of whether the gaming session is permitted is made at 714.Gaming sessions may be permitted based on various factors such as location of the intermediary gaming trusted device, duration of play, time of day, user information, gaming regulations, amount played, and the like.", "For example, if the intermediary gaming trusted device is determined to be in the parking lot where playing games of chance are not permitted, the gaming session will end and the intermediary gaming trusted device may cease to perform any gaming activities.", "In another example, if gaming regulations prohibit game play after the loss of $500 within a 24-hr period, the gaming session will end and the intermediary gaming trusted device may cease to perform any gaming activities.", "In no gaming session is permitted at 714, the method 700 may end.", "If the gaming session is permitted at 714, a determination of whether gaming information is requested is made at 716.If a request for gaming information is detected at 716, the method may return to step 706.If a request for gaming information is not detected at 716, the method 700 may end.", "While embodiments and applications of this invention have been shown and described, it would be apparent to those skilled in the art having the benefit of this disclosure that many more modifications than mentioned above are possible without departing from the inventive concepts herein." ] ]
Patent_15876095
[ [ "ENHANCED ON-DEMAND SERVICE FUNCTIONALITY IMPLEMENTED IN CASINO GAMING NETWORKS", "Various aspects described or referenced herein are directed to different methods, systems, and computer program products for implementing On Demand Services in Casino gaming establishments utilizing a Communications Network." ], [ "1.A computer implemented system, deployed at a casino establishment, for providing On Demand Services via a casino gaming network, the casino establishment including a first electronic gaming device (“first EGD”) and a second electronic gaming device (“second EGD”), the first and second electronic gaming devices being communicatively coupled to the casino gaming network, the first electronic gaming device being configured to enable a first patron to engage in first wager-based game at the first electronic gaming device, the first electronic gaming device including a first display and a first input interface, the second electronic gaming device being configured to enable a second patron to engage in second wager-based game at the second electronic gaming device, the second electronic gaming device including a second display and a second input interface, the system comprising: at least one processor; memory; an ODS database configured to store menu item data relating to a plurality of ODS menu items, including a first menu item and a second menu item; the at least one processor being operable to execute a plurality of instructions stored in the memory to: detect that the first patron is engaged in a wager-based gaming activities at the first EGD; track wagering activities performed by the first patron during a first time interval; display a first ODS Menu GUI at the first display of the first EGD, the first ODS Menu GUI being configurable to display selected menu item content representing products and/or services which are available to be ordered via interaction with the first ODS Menu GUI; analyze the first patron's tracked wagering activities to determine if the first patron's tracked wagering activities satisfy a first set of criteria; if it is determined that the first patron's tracked wagering activities satisfy the first set of criteria, automatically and dynamically configure the first ODS Menu GUI to: (i) display, at the first EGD display, a first portion of content representing the first menu item, (ii) enable the first patron to submit to the system, via interaction with the first ODS Menu GUI, a first ODS order which includes the first menu item, and (iii) cause at least one component of the system to generate and send a first set of information relating to the first ODS order to a first casino entity for handling fulfillment of the first OD S order, the first casino entity being located at the casino establishment; and if it is determined that the first patron's tracked wagering activities does not satisfy the first set of criteria, automatically and dynamically configure the first OD S Menu GUI to inhibit display of the first menu item at the first EGD display to thereby prevent the first patron from being able to order the first menu item via interaction with the first ODS Menu GUI.", "2.The computer implemented system of claim 1 wherein the system is further operable to cause the at least one processor to execute a plurality of instructions stored in the memory to: analyze the first patron's tracked wagering activities to determine if the first patron's tracked wagering activities satisfy a second set of criteria; if it is determined that the first patron's tracked wagering activities satisfy the second set of criteria, automatically and dynamically configure the first ODS Menu GUI to: (i) display, at the first EGD display, a second portion of content representing the second menu item, (ii) enable the first patron to submit to the system, via interaction with the first ODS Menu GUI, a second ODS order which includes the second menu item, and (iii) cause at least one component of the system to generate and send a second set of information relating to the second ODS order to a second casino entity for handling fulfillment of the second OD S order, the second casino entity being located at the casino establishment; and if it is determined that the first patron's tracked wagering activities does not satisfy the second set of criteria, automatically and dynamically configure the first OD S Menu GUI to inhibit display of the second menu item at the first EGD display to thereby prevent the first patron from being able to order the second menu item via interaction with the first ODS Menu GUI.", "3.The computer implemented system of claim 1 wherein the system is further operable to cause the at least one processor to execute a plurality of instructions stored in the memory to: track, after the first ODS order has been submitted to the system, additional wagering activities performed by the first patron during a subsequent time interval; analyze the first patron's tracked additional wagering activities to determine if the first patron's tracked additional wagering activities satisfy the first set of criteria; and if it is determined that the first patron's tracked additional wagering activities does not satisfy the first set of criteria, automatically cause at least one component of the system to cancel the first OD S order.", "4.The computer implemented system of claim 1 wherein the system is further operable to cause the at least one processor to execute a plurality of instructions stored in the memory to: analyze the first patron's tracked wagering activities to determine if the first patron's tracked wagering activities satisfy a second set of criteria; if it is determined that the first patron's tracked wagering activities satisfy the second set of criteria, automatically and dynamically: (i) determine a first purchase price of the first menu item; (ii) display, at the first ODS Menu GUI, the first purchase price of the first menu item, and (iii) enable the first patron to place an ODS order to purchase the first menu item at the first purchase price, via interaction with the first ODS Menu GUI; and analyze the first patron's tracked wagering activities to determine if the first patron's tracked wagering activities satisfy a third set of criteria; and if it is determined that the first patron's tracked wagering activities satisfy the third set of criteria, automatically and dynamically: (i) determine a second purchase price of the first menu item; (ii) display, at the first ODS Menu GUI, the second purchase price of the first menu item, and (iii) enable the first patron to place an ODS order to purchase the first menu item at the second purchase price, via interaction with the first ODS Menu GUI.", "5.The computer implemented system of claim 1: wherein the first menu item corresponds to a first beverage item; and wherein the first casino entity corresponds to a first bar at the casino establishment.", "6.The computer implemented system of claim 1: wherein the first menu item corresponds to a first food item; and wherein the first casino entity corresponds to a first restaurant at the casino establishment.", "7.The computer implemented system of claim 1: wherein the first menu item corresponds to a first service item; and wherein the first casino entity corresponds to a first service provider at the casino establishment.", "8.The computer implemented system of claim 1, wherein the first EGD includes a first EGD processor and first EGD memory for storing a first plurality of instructions, the first EGD further including a validator component operable to accept indicia of credit, the system being further operable to cause the first EGD processor to execute the first plurality of instructions for: receive, via the validator component, a first indicia of credit provided by the first patron, the first indicia of credit having a monetary value associated therewith; use monetary value of the first indicia to update a credit balance at the first EGM; and use a first portion of the credit balance to fund payment of the first ODS order.", "9.A computer implemented system, deployed at a casino establishment, for providing On Demand Services via a casino gaming network, the casino establishment including a first electronic gaming device (“first EGD”) and a second electronic gaming device (“second EGD”), the first and second electronic gaming devices being communicatively coupled to the casino gaming network, the first electronic gaming device being configured to enable a first patron to engage in first wager-based game at the first electronic gaming device, the first electronic gaming device including a first display and a first input interface, the second electronic gaming device being configured to enable a second patron to engage in second wager-based game at the second electronic gaming device, the second electronic gaming device including a second display and a second input interface, the system comprising: at least one processor; memory; an ODS database configured to store menu item data relating to a plurality of ODS menu items, including a first menu item and a second menu item; the at least one processor being operable to execute a plurality of instructions stored in the memory to: detect that the first patron is engaged in a wager-based gaming activities at the first EGD; display a first ODS Menu GUI at the first display of the first EGD, the first ODS Menu GUI being configurable to display selected menu item content representing products and/or services which are available to be ordered via interaction with the first ODS Menu GUI; determine if the first patron is a VIP patron or a non-VIP patron; if it is determined that the first patron is a VIP patron, automatically and dynamically configure the first ODS Menu GUI to: (i) display, at the first EGD display, a first portion of content representing the first menu item, (ii) enable the first patron to submit to the system, via interaction with the first ODS Menu GUI, a first ODS order which includes the first menu item, and (iii) cause at least one component of the system to generate and send a first set of information relating to the first ODS order to a first casino entity for handling fulfillment of the first ODS order, the first casino entity being located at the casino establishment; and if it is determined that the first patron is a non-VIP patron, automatically and dynamically configure the first ODS Menu GUI to inhibit display of the first menu item at the first EGD display to thereby prevent the first patron from being able to order the first menu item via interaction with the first ODS Menu GUI.", "10.The computer implemented system of claim 9 wherein the system is further operable to cause the at least one processor to execute a plurality of instructions stored in the memory to: if it is determined that the first patron is a VIP patron, automatically and dynamically: (i) determine a first purchase price of the first menu item; (ii) display, at the first ODS Menu GUI, the first purchase price of the first menu item, and (iii) enable the first patron to place an ODS order to purchase the first menu item at the first purchase price, via interaction with the first ODS Menu GUI; and if it is determined that the first patron is a non-VIP patron, automatically and dynamically: (i) determine a second purchase price of the first menu item; (ii) display, at the first ODS Menu GUI, the second purchase price of the first menu item, and (iii) enable the first patron to place an ODS order to purchase the first menu item at the second purchase price, via interaction with the first ODS Menu GUI.", "11.The computer implemented system of claim 9: wherein the first menu item corresponds to a first beverage item; and wherein the first casino entity corresponds to a first bar at the casino establishment.", "12.The computer implemented system of claim 9: wherein the first menu item corresponds to a first food item; and wherein the first casino entity corresponds to a first restaurant at the casino establishment.", "13.The computer implemented system of claim 9: wherein the first menu item corresponds to a first service item; and wherein the first casino entity corresponds to a first service provider at the casino establishment.", "14.The computer implemented system of claim 9, wherein the first EGD includes a first EGD processor and first EGD memory for storing a first plurality of instructions, the first EGD further including a validator component operable to accept indicia of credit, the system being further operable to cause the first EGD processor to execute the first plurality of instructions for: receive, via the validator component, a first indicia of credit provided by the first patron, the first indicia of credit having a monetary value associated therewith; use monetary value of the first indicia to update a credit balance at the first EGM; and use a first portion of the credit balance to fund payment of the first ODS order.", "15.A computer implemented method, deployed at a casino establishment, for providing On Demand Services via a casino gaming network, the casino establishment including a first electronic gaming device (“first EGD”) and a second electronic gaming device (“second EGD”), the first and second electronic gaming devices being communicatively coupled to the casino gaming network, the first electronic gaming device being configured to enable a first patron to engage in first wager-based game at the first electronic gaming device, the first electronic gaming device including a first display and a first input interface, the second electronic gaming device being configured to enable a second patron to engage in second wager-based game at the second electronic gaming device, the second electronic gaming device including a second display and a second input interface; the system including an ODS database configured to store menu item data relating to a plurality of ODS menu items, including a first menu item and a second menu item; the system further including at least one processor, and a memory storing a plurality of instructions, the method comprising causing the at least one processor to execute the plurality of instructions stored in the memory to: detect that the first patron is engaged in a wager-based gaming activities at the first EGD; track wagering activities performed by the first patron during a first time interval; display a first ODS Menu GUI at the first display of the first EGD, the first ODS Menu GUI being configurable to display selected menu item content representing products and/or services which are available to be ordered via interaction with the first ODS Menu GUI; analyze the first patron's tracked wagering activities to determine if the first patron's tracked wagering activities satisfy a first set of criteria; in response to determining that the first patron's tracked wagering activities satisfy the first set of criteria, automatically and dynamically configure the first ODS Menu GUI to: (i) display, at the first EGD display, a first portion of content representing the first menu item, (ii) enable the first patron to submit to the system, via interaction with the first ODS Menu GUI, a first ODS order which includes the first menu item, and (iii) cause at least one component of the system to generate and send a first set of information relating to the first ODS order to a first casino entity for handling fulfillment of the first OD S order, the first casino entity being located at the casino establishment; and in response to determining that the first patron's tracked wagering activities does not satisfy the first set of criteria, automatically and dynamically configure the first OD S Menu GUI to inhibit display of the first menu item at the first EGD display to thereby prevent the first patron from being able to order the first menu item via interaction with the first ODS Menu GUI.", "16.The computer implemented method of claim 15 further comprising causing the at least one processor to execute a plurality of instructions stored in the memory to: analyze the first patron's tracked wagering activities to determine if the first patron's tracked wagering activities satisfy a second set of criteria; in response to determining that the first patron's tracked wagering activities satisfy the second set of criteria, automatically and dynamically: (i) determine a first purchase price of the first menu item; (ii) display, at the first ODS Menu GUI, the first purchase price of the first menu item, and (iii) enable the first patron to place an ODS order to purchase the first menu item at the first purchase price, via interaction with the first ODS Menu GUI; and analyze the first patron's tracked wagering activities to determine if the first patron's tracked wagering activities satisfy a third set of criteria; and in response to determining that the first patron's tracked wagering activities satisfy the third set of criteria, automatically and dynamically: (i) determine a second purchase price of the first menu item; (ii) display, at the first ODS Menu GUI, the second purchase price of the first menu item, and (iii) enable the first patron to place an ODS order to purchase the first menu item at the second purchase price, via interaction with the first ODS Menu GUI.", "17.A computer implemented method, deployed at a casino establishment, for providing On Demand Services via a casino gaming network, the casino establishment including a first electronic gaming device (“first EGD”) and a second electronic gaming device (“second EGD”), the first and second electronic gaming devices being communicatively coupled to the casino gaming network, the first electronic gaming device being configured to enable a first patron to engage in first wager-based game at the first electronic gaming device, the first electronic gaming device including a first display and a first input interface, the second electronic gaming device being configured to enable a second patron to engage in second wager-based game at the second electronic gaming device, the second electronic gaming device including a second display and a second input interface; the system including an ODS database configured to store menu item data relating to a plurality of ODS menu items, including a first menu item and a second menu item; the system further including at least one processor, and a memory storing a plurality of instructions, the method comprising causing the at least one processor to execute the plurality of instructions stored in the memory to: detect that the first patron is engaged in a wager-based gaming activities at the first EGD; display a first ODS Menu GUI at the first display of the first EGD, the first ODS Menu GUI being configurable to display selected menu item content representing products and/or services which are available to be ordered via interaction with the first ODS Menu GUI; determine if the first patron is a VIP patron or a non-VIP patron; in response to determining that the first patron is a VIP patron, automatically and dynamically configure the first ODS Menu GUI to: (i) display, at the first EGD display, a first portion of content representing the first menu item, (ii) enable the first patron to submit to the system, via interaction with the first OD S Menu GUI, a first ODS order which includes the first menu item, and (iii) cause at least one component of the system to generate and send a first set of information relating to the first ODS order to a first casino entity for handling fulfillment of the first ODS order, the first casino entity being located at the casino establishment; and in response to determining that the first patron is a non-VIP patron, automatically and dynamically configure the first ODS Menu GUI to inhibit display of the first menu item at the first EGD display to thereby prevent the first patron from being able to order the first menu item via interaction with the first ODS Menu GUI.", "18.The computer implemented system of claim 9 further comprising causing the at least one processor to execute a plurality of instructions stored in the memory to: in response to determining that the first patron is a VIP patron, automatically and dynamically: (i) determine a first purchase price of the first menu item; (ii) display, at the first ODS Menu GUI, the first purchase price of the first menu item, and (iii) enable the first patron to place an ODS order to purchase the first menu item at the first purchase price, via interaction with the first ODS Menu GUI; and in response to determining that the first patron is a non-VIP patron, automatically and dynamically: (i) determine a second purchase price of the first menu item; (ii) display, at the first ODS Menu GUI, the second purchase price of the first menu item, and (iii) enable the first patron to place an ODS order to purchase the first menu item at the second purchase price, via interaction with the first ODS Menu GUI." ], [ "<SOH> BACKGROUND <EOH>The present disclosure generally relates to business transactions and services conducted at casino gaming establishments.", "More particularly, the present disclosure relates to techniques for implementing enhanced on-demand service functionality in casino gaming networks." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>FIG.", "1 illustrates a simplified block diagram of a specific example embodiment of a Casino Network 100 which may be configured or designed to implement various On Demand Service(s) and feature(s) described and/or referenced herein.", "FIG.", "2 shows an example block diagram of an electronic gaming system 200 in accordance with a specific embodiment.", "FIG.", "3 shows a perspective view of an example gaming machine 302 in accordance with a specific embodiment.", "FIG.", "4 shows a block diagram of electronic gaming device 400 , in accordance with a specific embodiment.", "FIG.", "5 is a simplified block diagram of an exemplary intelligent electronic gaming system 500 in accordance with a specific embodiment.", "FIG.", "6 is a simplified block diagram of an exemplary mobile gaming device 600 in accordance with a specific embodiment.", "FIG.", "7 illustrates an example embodiment of a System Server 780 which may be used for implementing various aspects/features described herein.", "FIG.", "8 illustrates an example of a functional block diagram of a Gaming System Server in accordance with a specific embodiment.", "FIG.", "9 shows a block diagram illustrating components of a gaming system 900 which may be used for implementing various aspects of example embodiments.", "FIGS.", "10-64 illustrate various system diagrams, procedural flows, GUIs, and screenshots relating to various aspects of the On Demand Services techniques described herein.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "RELATED APPLICATION DATA The present application claims benefit, pursuant to the provisions of 35 U.S.C.", "§ 119, of U.S.", "Provisional Application Ser.", "No.", "62/116,726 (Attorney Docket No.", "SYNBP002P), titled “ENHANCED PLAYER SUITE FUNCTIONALITY IMPLEMENTED IN CASINO GAMING NETWORKS”, naming Washington et al.", "as inventors, and filed 16 Feb. 2015, the entirety of which is incorporated herein by reference for all purposes.", "This application is a continuation application, pursuant to the provisions of 35 U.S.C.", "§ 120, of prior U.S. patent application Ser.", "No.", "15/045,234 (Attorney Docket No.", "SYNBP002US) titled “ENHANCED ON-DEMAND SERVICE FUNCTIONALITY IMPLEMENTED IN CASINO GAMING NETWORKS” by Washington et al., filed on 16 Feb. 2016, the entirety of which is incorporated herein by reference for all purposes.", "BACKGROUND The present disclosure generally relates to business transactions and services conducted at casino gaming establishments.", "More particularly, the present disclosure relates to techniques for implementing enhanced on-demand service functionality in casino gaming networks.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates a simplified block diagram of a specific example embodiment of a Casino Network 100 which may be configured or designed to implement various On Demand Service(s) and feature(s) described and/or referenced herein.", "FIG.", "2 shows an example block diagram of an electronic gaming system 200 in accordance with a specific embodiment.", "FIG.", "3 shows a perspective view of an example gaming machine 302 in accordance with a specific embodiment.", "FIG.", "4 shows a block diagram of electronic gaming device 400, in accordance with a specific embodiment.", "FIG.", "5 is a simplified block diagram of an exemplary intelligent electronic gaming system 500 in accordance with a specific embodiment.", "FIG.", "6 is a simplified block diagram of an exemplary mobile gaming device 600 in accordance with a specific embodiment.", "FIG.", "7 illustrates an example embodiment of a System Server 780 which may be used for implementing various aspects/features described herein.", "FIG.", "8 illustrates an example of a functional block diagram of a Gaming System Server in accordance with a specific embodiment.", "FIG.", "9 shows a block diagram illustrating components of a gaming system 900 which may be used for implementing various aspects of example embodiments.", "FIGS.", "10-64 illustrate various system diagrams, procedural flows, GUIs, and screenshots relating to various aspects of the On Demand Services techniques described herein.", "DETAILED DESCRIPTION OF EXAMPLE EMBODIMENTS Overview Various aspects described or referenced herein are directed to different methods, systems, and computer program products for implementing On Demand Services in Casino gaming establishments utilizing a Communications Network.", "One aspect disclosed herein is directed to different methods, systems, and computer program products for implementing On Demand Services in a casino gaming network, the casino gaming network including a first electronic gaming device communicatively coupled to the casino gaming network, the first electronic gaming being configured to enable a first patron to engage in first wager-based game at the first electronic gaming device, the first electronic gaming device including a first display and a first input interface.", "In at least one embodiment, an On-Demand Services System (“ODS System”) may be communicatively coupled to the first electronic gaming device via the casino gaming network.", "In at least one embodiment, various method(s), system(s) and/or computer program product(s) may be operable to cause at least one processor to execute a plurality of instructions for: causing a first On-Demand Services graphical user interface (“ODS GUI”) to be displayed at the first display of the first EGM; the first ODS GUI being configured or designed to enable the first patron to interact with the first ODS GUI via the first input interface; the first ODS GUI being configured or designed to enable the first patron to access a first set of On Demand Services via interaction with the first ODS GUI; the first ODS GUI being configured or designed to enable the first patron to submit to the OD S System, via interaction with the first OD S GUI, a first OD S order relating to a first On Demand Service; causing at least one component of the ODS System to generate and send a first set of information relating to the first ODS order to a first casino entity for handling fulfillment of the first ODS order; causing at least one component of the ODS System to automatically track a current status of the first ODS order; and causing at least one component of the ODS System to provide user access to real-time status information relating to the current status of the first OD S order.", "In at least one embodiment, the first set of On Demand Services includes: Beverage On Demand (BOD) Service; Host On Demand (HOD) Service; Valet On Demand (VOD) Service; Security On Demand (SOD) Service; and Weather On Demand (WOD) Service.", "In at least one embodiment, the first On Demand Service corresponds to a Beverage On Demand (BOD) Service; the first ODS order includes an order for a first beverage item; and the first casino entity corresponds to a first bar of the casino.", "In at least one embodiment, various method(s), system(s) and/or computer program product(s) may be further operable to cause at least one processor to execute additional instructions for: causing at least one component of the ODS System to automatically monitor a current status of ODS orders assigned to be handled by the first bar; and causing at least one component of the ODS System to provide user access to real-time status information relating to the current status of selected ODS orders assigned to be handled by the first bar.", "In at least one embodiment, various method(s), system(s) and/or computer program product(s) may be further operable to cause at least one processor to execute additional instructions for: causing at least one component of the ODS System to determine a current location of the first patron; causing at least one component of the ODS System to identify of a first casino waitstaff who has been assigned to deliver the first OD S order to the first patron; and causing at least one component of the ODS System to automatically notify the identified casino waitstaff of the current location of the first patron.", "In at least one embodiment, the first On Demand Service corresponds to a Beverage On Demand (BOD) Service; the first ODS order includes an order for a first beverage item; and the first casino entity corresponds to a first bar of the casino.", "In at least one embodiment, various method(s), system(s) and/or computer program product(s) may be further operable to cause at least one processor to execute additional instructions for: causing at least one component of the ODS System to determine a current location of the first patron; causing at least one component of the ODS System to identify of a first casino waitstaff who has been assigned to deliver the first ODS order to the first patron; and causing at least one component of the OD S System to automatically notify the identified casino waitstaff of the current location of the first patron.", "In at least one embodiment, the first On Demand Service corresponds to a Beverage On Demand (BOD) Service; the first ODS order includes an order for a first food item; and the first casino entity corresponds to a first restaurant of the casino.", "In at least one embodiment, various method(s), system(s) and/or computer program product(s) may be further operable to cause at least one processor to execute additional instructions for: causing at least one component of the ODS System to automatically monitor a current status of ODS orders assigned to be handled by the first restaurant; and causing at least one component of the ODS System to provide user access to real-time status information relating to the current status of selected ODS orders assigned to be handled by the first restaurant.", "In at least one embodiment, various method(s), system(s) and/or computer program product(s) may be further operable to cause at least one processor to execute additional instructions for: causing at least one component of the ODS System to automatically monitor a current status of multiple different ODS orders assigned to be handled by the first casino entity; and causing at least one component of the ODS System to provide user access to real-time status information relating to the current status of selected ODS orders assigned to be handled by the first casino entity.", "In at least one embodiment, the On Demand Services System may include functionality for enabling authorized personnel to fully customize and configure On Demand Services menus, sub-menus, and related GUIs.", "In at least one embodiment, the ODS Menu Manager Application enables authorized users (such as, for example, Casino Management and/or Food & Beverage Directors) to access, edit, customize, and/or modify selected On Demand Service application(s) menus, sub-menus and GUIs (e.g., BOD, HOD, SOD, VOD, WOD, Reports, etc.).", "In at least one embodiment, such authorized personnel may use the ODS Menu Manager Application to implement desired configurable updates and/or changes to one or more of the On Demand Service application(s) menus, sub-menus and GUIs, to thereby fully customize the services, features, and content provided by the On Demand Services System in a manner which conforms with the specific needs and/or desires of each individual property (e.g., casino property).", "Unlike many of today's Casino-based POS systems, the On Demand Services System of the present application may be configured or designed to provide functionality for allowing Casino managers (e.g., Food/Beverage managers, Valet managers, Host managers, Security managers, etc.)", "to continuously and/or periodically monitor, update, rearrange, remove, export, import, sort, itemize, track, date, locate, and/or deploy their entire menu system in a matter of seconds (e.g., in real-time).", "Additionally, the On Demand Services System may be configured or designed to enable On Demand Services menus to be dynamically populated, configured and/or modified on the fly (e.g., in real-time), without having to bring down or halt the gambling system/slot machine interface(s).", "Another unique and advantageous feature of the presently described On Demand Services System relates to the system's ability to automatically track (e.g., in real-time) orders which have been submitted to the On Demand Services System, and to provide real-time status updates about the current status of all (or selected) orders which have been submitted to the On Demand Services System.", "Another advantageous feature is the system's ability to provide casino personnel (and/or other authorized personnel) with access to real-time status information relating to specific orders and/or specific types of orders (e.g., pending orders, new orders, delivered orders, canceled orders, delayed orders, complementary orders, etc.).", "Another aspect disclosed herein is directed to different methods, systems, and computer program products for providing On Demand Services via a casino gaming network.", "In at least one embodiment, the casino establishment may include a first electronic gaming device (“first EGD”) and a second electronic gaming device (“second EGD”), the first and second electronic gaming devices being communicatively coupled to the casino gaming network.", "In at least one embodiment, the first electronic gaming device is configured to enable a first patron to engage in first wager-based game at the first electronic gaming device, the first electronic gaming device including a first display and a first input interface.", "In at least one embodiment, the second electronic gaming device is configured to enable a second patron to engage in second wager-based game at the second electronic gaming device, the second electronic gaming device including a second display and a second input interface.", "In at least one embodiment, various method(s), system(s) and/or computer program product(s) may be operable to cause at least one processor to execute a plurality of instructions to: detect that the first patron is engaged in a wager-based gaming activities at the first EGD; track wagering activities performed by the first patron during a first time interval; display a first OD S Menu GUI at the first display of the first EGD, the first OD S Menu GUI being configurable to display selected menu item content representing products and/or services which are available to be ordered via interaction with the first ODS Menu GUI; analyze the first patron's tracked wagering activities to determine if the first patron's tracked wagering activities satisfy a first set of criteria; if it is determined that the first patron's tracked wagering activities satisfy the first set of criteria, automatically and dynamically configure the first ODS Menu GUI to: (i) display, at the first EGD display, a first portion of content representing the first menu item, (ii) enable the first patron to submit to the system, via interaction with the first ODS Menu GUI, a first ODS order which includes the first menu item, and (iii) cause at least one component of the system to generate and send a first set of information relating to the first OD S order to a first casino entity for handling fulfillment of the first OD S order, the first casino entity being located at the casino establishment; and if it is determined that the first patron's tracked wagering activities does not satisfy the first set of criteria, automatically and dynamically configure the first ODS Menu GUI to inhibit display of the first menu item at the first EGD display to thereby prevent the first patron from being able to order the first menu item via interaction with the first ODS Menu GUI.", "In at least one embodiment, various method(s), system(s) and/or computer program product(s) may be further operable to cause at least one processor to execute additional instructions to: analyze the first patron's tracked wagering activities to determine if the first patron's tracked wagering activities satisfy a second set of criteria; if it is determined that the first patron's tracked wagering activities satisfy the second set of criteria, automatically and dynamically configure the first ODS Menu GUI to: (i) display, at the first EGD display, a second portion of content representing the second menu item, (ii) enable the first patron to submit to the system, via interaction with the first ODS Menu GUI, a second ODS order which includes the second menu item, and (iii) cause at least one component of the system to generate and send a second set of information relating to the second ODS order to a second casino entity for handling fulfillment of the second ODS order, the second casino entity being located at the casino establishment; and if it is determined that the first patron's tracked wagering activities does not satisfy the second set of criteria, automatically and dynamically configure the first ODS Menu GUI to inhibit display of the second menu item at the first EGD display to thereby prevent the first patron from being able to order the second menu item via interaction with the first ODS Menu GUI.", "In at least one embodiment, various method(s), system(s) and/or computer program product(s) may be further operable to cause at least one processor to execute additional instructions to: track, after the first ODS order has been submitted to the system, additional wagering activities performed by the first patron during a subsequent time interval; analyze the first patron's tracked additional wagering activities to determine if the first patron's tracked additional wagering activities satisfy the first set of criteria; and if it is determined that the first patron's tracked additional wagering activities does not satisfy the first set of criteria, automatically cause at least one component of the system to cancel the first ODS order.", "In at least one embodiment, various method(s), system(s) and/or computer program product(s) may be further operable to cause at least one processor to execute additional instructions to: analyze the first patron's tracked wagering activities to determine if the first patron's tracked wagering activities satisfy a second set of criteria; if it is determined that the first patron's tracked wagering activities satisfy the second set of criteria, automatically and dynamically: (i) determine a first purchase price of the first menu item; (ii) display, at the first OD S Menu GUI, the first purchase price of the first menu item, and (iii) enable the first patron to place an OD S order to purchase the first menu item at the first purchase price, via interaction with the first ODS Menu GUI; and analyze the first patron's tracked wagering activities to determine if the first patron's tracked wagering activities satisfy a third set of criteria; and if it is determined that the first patron's tracked wagering activities satisfy the third set of criteria, automatically and dynamically: (i) determine a second purchase price of the first menu item; (ii) display, at the first ODS Menu GUI, the second purchase price of the first menu item, and (iii) enable the first patron to place an ODS order to purchase the first menu item at the second purchase price, via interaction with the first ODS Menu GUI.", "In at least one embodiment, the first menu item corresponds to a first beverage item; and the first casino entity corresponds to a first bar at the casino establishment.", "In at least one embodiment, the first menu item corresponds to a first food item; and the first casino entity corresponds to a first restaurant at the casino establishment.", "In at least one embodiment, the first menu item corresponds to a first service item; and the first casino entity corresponds to a first service provider at the casino establishment.", "In at least one embodiment, the first EGD includes a first EGD processor and first EGD memory for storing a first plurality of instructions, the first EGD further including a validator component operable to accept indicia of credit, the system being further operable to cause the first EGD processor to execute the first plurality of instructions to: receive, via the validator component, a first indicia of credit provided by the first patron, the first indicia of credit having a monetary value associated therewith; use monetary value of the first indicia to update a credit balance at the first EGM; and use a first portion of the credit balance to fund payment of the first ODS order.", "Another aspect disclosed herein is directed to different methods, systems, and computer program products for providing On Demand Services via a casino gaming network.", "In at least one embodiment, the casino establishment may include a first electronic gaming device (“first EGD”) and a second electronic gaming device (“second EGD”), the first and second electronic gaming devices being communicatively coupled to the casino gaming network.", "In at least one embodiment, the first electronic gaming device is configured to enable a first patron to engage in first wager-based game at the first electronic gaming device, the first electronic gaming device including a first display and a first input interface.", "In at least one embodiment, the second electronic gaming device is configured to enable a second patron to engage in second wager-based game at the second electronic gaming device, the second electronic gaming device including a second display and a second input interface.", "In at least one embodiment, various method(s), system(s) and/or computer program product(s) may be operable to cause at least one processor to execute a plurality of instructions to: detect that the first patron is engaged in a wager-based gaming activities at the first EGD; display a first ODS Menu GUI at the first display of the first EGD, the first ODS Menu GUI being configurable to display selected menu item content representing products and/or services which are available to be ordered via interaction with the first ODS Menu GUI; determine if the first patron is a VIP patron or a non-VIP patron; if it is determined that the first patron is a VIP patron, automatically and dynamically configure the first OD S Menu GUI to: (i) display, at the first EGD display, a first portion of content representing the first menu item, (ii) enable the first patron to submit to the system, via interaction with the first OD S Menu GUI, a first OD S order which includes the first menu item, and (iii) cause at least one component of the system to generate and send a first set of information relating to the first ODS order to a first casino entity for handling fulfillment of the first ODS order, the first casino entity being located at the casino establishment; and if it is determined that the first patron is a non-VIP patron, automatically and dynamically configure the first ODS Menu GUI to inhibit display of the first menu item at the first EGD display to thereby prevent the first patron from being able to order the first menu item via interaction with the first ODS Menu GUI.", "In at least one embodiment, various method(s), system(s) and/or computer program product(s) may be further operable to cause at least one processor to execute additional instructions to: if it is determined that the first patron is a VIP patron, automatically and dynamically: (i) determine a first purchase price of the first menu item; (ii) display, at the first ODS Menu GUI, the first purchase price of the first menu item, and (iii) enable the first patron to place an ODS order to purchase the first menu item at the first purchase price, via interaction with the first ODS Menu GUI; and if it is determined that the first patron is a non-VIP patron, automatically and dynamically: (i) determine a second purchase price of the first menu item; (ii) display, at the first OD S Menu GUI, the second purchase price of the first menu item, and (iii) enable the first patron to place an ODS order to purchase the first menu item at the second purchase price, via interaction with the first ODS Menu GUI.", "Another aspect disclosed herein is directed to different methods, systems, and computer program products for providing On Demand Services via a casino gaming network, the casino establishment including a first electronic gaming device (“first EGD”) and a second electronic gaming device (“second EGD”), the first and second electronic gaming devices being communicatively coupled to the casino gaming network.", "In at least one embodiment, the first electronic gaming device is configured to enable a first patron to engage in first wager-based game at the first electronic gaming device, the first electronic gaming device including a first display and a first input interface.", "In at least one embodiment, the second electronic gaming device is configured to enable a second patron to engage in second wager-based game at the second electronic gaming device, the second electronic gaming device including a second display and a second input interface.", "In at least one embodiment, an ODS database is provided which is configured to store menu item data relating to a plurality of ODS menu items, including a first menu item and a second menu item.", "In at least one embodiment, various method(s), system(s) and/or computer program product(s) may be operable to cause at least one processor to execute a plurality of instructions to: detect that the first patron is engaged in a wager-based gaming activities at the first EGD; track wagering activities performed by the first patron during a first time interval; display a first ODS Menu GUI at the first display of the first EGD, the first ODS Menu GUI being configurable to display selected menu item content representing products and/or services which are available to be ordered via interaction with the first ODS Menu GUI; analyze the first patron's tracked wagering activities to determine if the first patron's tracked wagering activities satisfy a first set of criteria; in response to determining that the first patron's tracked wagering activities satisfy the first set of criteria, automatically and dynamically configure the first ODS Menu GUI to: (i) display, at the first EGD display, a first portion of content representing the first menu item, (ii) enable the first patron to submit to the system, via interaction with the first ODS Menu GUI, a first ODS order which includes the first menu item, and (iii) cause at least one component of the system to generate and send a first set of information relating to the first ODS order to a first casino entity for handling fulfillment of the first OD S order, the first casino entity being located at the casino establishment; and in response to determining that the first patron's tracked wagering activities does not satisfy the first set of criteria, automatically and dynamically configure the first ODS Menu GUI to inhibit display of the first menu item at the first EGD display to thereby prevent the first patron from being able to order the first menu item via interaction with the first ODS Menu GUI.", "In at least one embodiment, various method(s), system(s) and/or computer program product(s) may be operable to cause at least one processor to execute a plurality of instructions to: analyze the first patron's tracked wagering activities to determine if the first patron's tracked wagering activities satisfy a second set of criteria; in response to determining that the first patron's tracked wagering activities satisfy the second set of criteria, automatically and dynamically: (i) determine a first purchase price of the first menu item; (ii) display, at the first OD S Menu GUI, the first purchase price of the first menu item, and (iii) enable the first patron to place an OD S order to purchase the first menu item at the first purchase price, via interaction with the first ODS Menu GUI; and analyze the first patron's tracked wagering activities to determine if the first patron's tracked wagering activities satisfy a third set of criteria; and in response to determining that the first patron's tracked wagering activities satisfy the third set of criteria, automatically and dynamically: (i) determine a second purchase price of the first menu item; (ii) display, at the first ODS Menu GUI, the second purchase price of the first menu item, and (iii) enable the first patron to place an OD S order to purchase the first menu item at the second purchase price, via interaction with the first ODS Menu GUI.", "Another aspect disclosed herein is directed to different methods, systems, and computer program products for providing On Demand Services via a casino gaming network, the casino establishment including a first electronic gaming device (“first EGD”) and a second electronic gaming device (“second EGD”), the first and second electronic gaming devices being communicatively coupled to the casino gaming network.", "In at least one embodiment, the first electronic gaming device is configured to enable a first patron to engage in first wager-based game at the first electronic gaming device, the first electronic gaming device including a first display and a first input interface.", "In at least one embodiment, the second electronic gaming device is configured to enable a second patron to engage in second wager-based game at the second electronic gaming device, the second electronic gaming device including a second display and a second input interface.", "In at least one embodiment, an ODS database is provided which is configured to store menu item data relating to a plurality of OD S menu items, including a first menu item and a second menu item.", "In at least one embodiment, various method(s), system(s) and/or computer program product(s) may be operable to cause at least one processor to execute a plurality of instructions to: detect that the first patron is engaged in a wager-based gaming activities at the first EGD; display a first ODS Menu GUI at the first display of the first EGD, the first ODS Menu GUI being configurable to display selected menu item content representing products and/or services which are available to be ordered via interaction with the first ODS Menu GUI; determine if the first patron is a VIP patron or a non-VIP patron; in response to determining that the first patron is a VIP patron, automatically and dynamically configure the first ODS Menu GUI to: (i) display, at the first EGD display, a first portion of content representing the first menu item, (ii) enable the first patron to submit to the system, via interaction with the first ODS Menu GUI, a first ODS order which includes the first menu item, and (iii) cause at least one component of the system to generate and send a first set of information relating to the first ODS order to a first casino entity for handling fulfillment of the first ODS order, the first casino entity being located at the casino establishment; and in response to determining that the first patron is a non-VIP patron, automatically and dynamically configure the first ODS Menu GUI to inhibit display of the first menu item at the first EGD display to thereby prevent the first patron from being able to order the first menu item via interaction with the first ODS Menu GUI.", "In at least one embodiment, various method(s), system(s) and/or computer program product(s) may be operable to cause at least one processor to execute a plurality of instructions to: in response to determining that the first patron is a VIP patron, automatically and dynamically: (i) determine a first purchase price of the first menu item; (ii) display, at the first ODS Menu GUI, the first purchase price of the first menu item, and (iii) enable the first patron to place an ODS order to purchase the first menu item at the first purchase price, via interaction with the first ODS Menu GUI; and in response to determining that the first patron is a non-VIP patron, automatically and dynamically: (i) determine a second purchase price of the first menu item; (ii) display, at the first ODS Menu GUI, the second purchase price of the first menu item, and (iii) enable the first patron to place an OD S order to purchase the first menu item at the second purchase price, via interaction with the first ODS Menu GUI.", "Various objects, features and advantages of the various aspects described or referenced herein will become apparent from the following descriptions of its example embodiments, which descriptions should be taken in conjunction with the accompanying drawings.", "SPECIFIC EXAMPLE EMBODIMENTS Various techniques will now be described in detail with reference to a few example embodiments thereof as illustrated in the accompanying drawings.", "In the following description, numerous specific details are set forth in order to provide a thorough understanding of one or more aspects and/or features described or reference herein.", "It will be apparent, however, to one skilled in the art, that one or more aspects and/or features described or reference herein may be practiced without some or all of these specific details.", "In other instances, well known process steps and/or structures have not been described in detail in order to not obscure some of the aspects and/or features described or reference herein.", "One or more different inventions may be described in the present application.", "Further, for one or more of the invention(s) described herein, numerous embodiments may be described in this patent application, and are presented for illustrative purposes only.", "The described embodiments are not intended to be limiting in any sense.", "One or more of the invention(s) may be widely applicable to numerous embodiments, as is readily apparent from the disclosure.", "These embodiments are described in sufficient detail to enable those skilled in the art to practice one or more of the invention(s), and it is to be understood that other embodiments may be utilized and that structural, logical, software, electrical and other changes may be made without departing from the scope of the one or more of the invention(s).", "Accordingly, those skilled in the art will recognize that the one or more of the invention(s) may be practiced with various modifications and alterations.", "Particular features of one or more of the invention(s) may be described with reference to one or more particular embodiments or figures that form a part of the present disclosure, and in which are shown, by way of illustration, specific embodiments of one or more of the invention(s).", "It should be understood, however, that such features are not limited to usage in the one or more particular embodiments or figures with reference to which they are described.", "The present disclosure is neither a literal description of all embodiments of one or more of the invention(s) nor a listing of features of one or more of the invention(s) that must be present in all embodiments.", "Headings of sections provided in this patent application and the title of this patent application are for convenience only, and are not to be taken as limiting the disclosure in any way.", "Devices that are in communication with each other need not be in continuous communication with each other, unless expressly specified otherwise.", "In addition, devices that are in communication with each other may communicate directly or indirectly through one or more intermediaries.", "A description of an embodiment with several components in communication with each other does not imply that all such components are required.", "To the contrary, a variety of optional components are described to illustrate the wide variety of possible embodiments of one or more of the invention(s).", "Further, although process steps, method steps, algorithms or the like may be described in a sequential order, such processes, methods and algorithms may be configured to work in alternate orders.", "In other words, any sequence or order of steps that may be described in this patent application does not, in and of itself, indicate a requirement that the steps be performed in that order.", "The steps of described processes may be performed in any order practical.", "Further, some steps may be performed simultaneously despite being described or implied as occurring non-simultaneously (e.g., because one step is described after the other step).", "Moreover, the illustration of a process by its depiction in a drawing does not imply that the illustrated process is exclusive of other variations and modifications thereto, does not imply that the illustrated process or any of its steps are necessary to one or more of the invention(s), and does not imply that the illustrated process is preferred.", "When a single device or article is described, it will be readily apparent that more than one device/article (whether or not they cooperate) may be used in place of a single device/article.", "Similarly, where more than one device or article is described (whether or not they cooperate), it will be readily apparent that a single device/article may be used in place of the more than one device or article.", "The functionality and/or the features of a device may be alternatively embodied by one or more other devices that are not explicitly described as having such functionality/features.", "Thus, other embodiments of one or more of the invention(s) need not include the device itself.", "Techniques and mechanisms described or reference herein will sometimes be described in singular form for clarity.", "However, it should be noted that particular embodiments include multiple iterations of a technique or multiple instantiations of a mechanism unless noted otherwise.", "Casino's and gambling are a proven billion dollar industry.", "The waitstaff alone bring in millions of dollars annually.", "However, with all this success and money coming in the doors, there still remain significant untapped market opportunities that may bring in even more revenue for the casino.", "For example, one such untapped market opportunity relates to patrons seated at gaming machines who are “looking for the drink girl.” In today's fast paced world, patrons of gaming establishments tend to be impatient, and generally dislike having to wait for a server to “hopefully stroll by.” They want their needs/desires attended to, and in an expeditious and timely manner.", "However, given the casinos limited resources, it is generally difficult for casino patrons to obtain timely service.", "This issue is particularly problematic in specific areas of the casino such as, for example, the low-wager play zones of the casino.", "For example, a lone gambler occupying a seat at a gaming machine in a low-wager play zone may be forced to wait an undesirably long time for a server to come by and attend to the patron's order.", "Moreover, other types casino services (such as, for example, security, valet, medical aid, etc.)", "are neither easily accessible nor timely available to such patrons.", "In an effort to address at least some of these issues, various On-Demand Service (ODS) techniques and features are described herein for providing casino patrons with instant, real-time access to selected casino services via use of the casino's electronic gaming machine display(s) and interface(s).", "For example, as described in greater detail herein, a casino network may be communicatively coupled to an On Demand (ODS) System which is configured or designed to provide various types of On Demand Services such as, for example, one or more of the following (or combinations thereof): Beverage On Demand (BOD) service(s) (e.g., which may include services for food and/or beverages), Host On Demand (HOD) service(s), Security On Demand (SOD) service(s), Valet On Demand (VOD) service(s), Weather On Demand (WOD) service(s), Menu Manager (MMR) service(s), AppSite service(s), etc.", "According to different embodiments, such On Demand Services may be implemented at Casino establishments and/or other wager-based (and/or non-wager based) gaming establishments via one or more communications networks.", "Unlike many of today's Casino-based POS systems, the On Demand Services System of the present application may be configured or designed to provide functionality for allowing Casino managers (e.g., Food/Beverage managers, Valet managers, Host managers, Security managers, etc.)", "to continuously and/or periodically monitor, update, rearrange, remove, export, import, sort, itemize, track, date, locate, and/or deploy their entire menu system in a matter of seconds (e.g., in real-time).", "Additionally, the On Demand Services System may be configured or designed to enable On Demand Services menus to be dynamically populated, configured and/or modified on the fly (e.g., in real-time), without having to bring down or halt the gambling system/slot machine interface(s).", "By way of example, an On Demand Services System may be integrated into an existing casino gaming network such as, for example, The Cosmopolitan Casino in Las Vegas, Nev.", "In this particular example, it may be assumed that “Lobster Appetizer” may be a food item which is occasionally offered as part of the Beverage On Demand (BOD) service.", "However, in this particular example, it may initially be assumed that the “Lobster Appetizer” is currently unavailable at the Casino due to lack of inventory/supply.", "Consequently, in at least one embodiment, the On Demand Services System may dynamically detect this current lack of inventory/supply of lobster, and may automatically and dynamically respond by updating the BOD service menu(s) to show that the Lobster Appetizer is currently unavailable.", "In some embodiments, a Food/Beverage manager may elect to access the BOD service menu configuration interface to manually update the BOD service menu(s) to show that the Lobster Appetizer is currently unavailable.", "Subsequently, a delivery of lobster may arrive at the Casino and the details of the lobster delivery (e.g., quantity, weight, price, etc.)", "may be entered (e.g., either automatically or manually) into the Casino's inventory system.", "In one embodiment, the On Demand Services System may automatically detect the updated availability of lobster in the inventory system, and in response, may automatically and dynamically update the BOD service menu(s) to show that the Lobster Appetizer is currently available.", "Accordingly, within a matter of moments from detecting the availability of lobster in the Casino inventory, the Lobster Appetizer menu item may be made available for ordering by a patron, for example, via a BOD Service Menu GUI (e.g., 1024, FIG.", "10; 1124, FIG.", "11) of an electronic gaming machine (EGM).", "Moreover, in at least some embodiments, this may be accomplished without having to interrupt, halt, or otherwise interfere with the EGM's current operation(s)/activitie(s).", "Next, let's assume that the lobster delivery was a small shipment, and that the entirety of available lobster supply is sold out within twenty minutes.", "Just as quickly and seamlessly as the Lobster Appetizer was added (or made available for ordering) as BOD Service Menu item, this menu item may be dynamically removed (or made unavailable for ordering) via the On Demand Services System in response to detecting that the identified menu item (or at least one ingredient of the identified menu item, such as lobster) is no longer available.", "In some embodiments, the On Demand Services System may automatically analyze the details of the currently available supply of lobster, dynamically determine or estimate the quantity of available Lobster Appetizers which may be available for order (e.g., based on current supply and existing orders in queue), and dynamically track and update the BOD service menu(s) to show the estimated number of Lobster Appetizers which are currently available to be ordered.", "In some embodiments, if a food or beverage item is determined to be in short supply, the On Demand Services System may automatically and dynamically impose ordering restrictions on such identified items (such as, for example, by limiting a patron to a maximum of 2 orders of a given food/beverage item which is in short supply).", "On Demand Services Components, Systems, Sub-Systems FIGS.", "10-64 illustrate various system diagrams, procedural flows, GUIs, and screenshots relating to various aspects of the On Demand Services described herein.", "FIG.", "10 shows an example portion of a casino network 1010 which includes an electronic gaming machine (EGM 1022) deployed at the casino floor 1020 (e.g., serving as a front-end system for providing On Demand Services to casino patrons), and including one or more backend displays 1032 deployed at the Casino's backend system 1030.In the specific example embodiment of FIG.", "10, the EGM 1022 is configured or designed to display vertical-oriented On Demand Service window menu GUIs (e.g., 1024), which are configured or designed to provide players/patrons with access to various types of On Demand Services.", "Examples of different vertical-oriented On Demand Service window menu GUIs which may be displayed via the EGM's display are illustrated in FIGS.", "12-16.Additionally, as illustrated in the example embodiment of FIG.", "10 the backend system display 1032 is shown displaying a Menu Manager GUI such as that illustrated and described in greater detail with respect to FIG.", "17.FIG.", "11 shows an example portion of a casino network 1010 which includes an electronic gaming machine (EGM 1122) deployed at the casino floor 1120 (e.g., serving as a front-end system for providing On Demand Services to casino patrons), and including one or more backend displays 1132 deployed at the Casino's backend system 1130.In the specific example embodiment of FIG.", "11, the EGM 1122 is configured or designed to display horizontal-oriented On Demand Service window menu GUIs (e.g., 1124), which are configured or designed to provide players/patrons with access to various types of On Demand Services.", "According to different embodiments, the On Demand Services System may be configured or designed to host a plurality of different interfaces (e.g., electronic menus, GUIs, applications, etc., some or all of which may be individually enabled/disabled) that provide a dynamic and fully configurable patron services suite.", "Examples of some of the various interfaces/applications may include, but are not limited to, one or more of the following (or combinations thereof): Beverage On Demand® (BOD) Service menu(s)/interface(s), as illustrated, for example, in FIGS.", "12, 30-49, 55-59.Host On Demand® (HOD) Service menu(s)/interface(s), as illustrated, for example, in FIGS.", "13, 19-21.Security On Demand® (SOD) Service menu(s)/interface(s), as illustrated, for example, in FIGS.", "14, 22-25.Valet On Demand® (VOD) Service menu(s)/interface(s), as illustrated, for example, in FIGS.", "15, 26-28.Weather On Demand® (WOD) Service menu(s)/interface(s), as illustrated, for example, in FIGS.", "16, 29.Reports & Data Analytics Application(s), as illustrated, for example, in FIGS.", "50-54.On-Demand Service Application Configuration and Menu Management Application(s), as illustrated, for example, in FIGS.", "17, 18.Windows Services.", "Etc.", "In at least one embodiment, the On-Demand Service Application Configuration and Menu Management Application (also referred to herein as the “ODS Menu Manager” Application or the “AppSite” Application) may be configured or designed to include functionality for enabling authorized personnel to fully customize and configure On Demand Services menus, sub-menus, and related GUIs.", "In at least one embodiment, the ODS Menu Manager Application enables authorized users (such as, for example, Casino Management and/or Food & Beverage Directors) to access, edit, customize, and/or modify selected On Demand Service application(s) menus, sub-menus and GUIs (e.g., BOD, HOD, SOD, VOD, WOD, Reports, etc.).", "In at least one embodiment, such authorized personnel may use the ODS Menu Manager Application to implement desired configurable updates and/or changes to one or more of the On Demand Service application(s) menus, sub-menus and GUIs, to thereby fully customize the services, features, and content provided by the On Demand Services System in a manner which conforms with the specific needs and/or desires of each individual property (e.g., casino property).", "According to different embodiments, the ODS Menu Manager Application may be configured or designed to run as a local application, a remote application, and/or as a website or webpage based interface that ties into present day gambling/player management systems.", "FIG.", "18 shows an example embodiment illustrating of a portion of an On Demand Services System architecture, illustrating how the ODS Menu Manager Application may be configured or designed to function as an admin management hub for managing On Demand products and services.", "As illustrated in the example embodiment of FIG.", "18, an On Demand Services Menu Manager 1802 may be implemented at server (e.g., a backend casino server of the casino's gaming network), and may be configured or designed to interface with various On Demand Services Manager components (e.g., BOD Menu Manager 1808, Report Menu Manager 1810, WOD Menu Manager 1812, VOD Menu Manager 1814, HDD Menu Manager 1816, SOD Menu Manager 1818, etc.", "), each of which may be configured or designed to include functionality for enabling a user (e.g., authorized administrators, Casino Management personnel, ODS Directors, etc.)", "to configure, access, edit, customize, and/or modify selected On Demand Service application(s) menus, sub-menus, GUIs, and/or related content (e.g., 1840).", "FIG.", "17 shows an example screenshot of a ODS Menu Manager Application GUI 1700 which has been configured or designed to provide authorized users with access to various On Demand applications, services, products, and their related menu interfaces, content, and features, including, for example, one or more of the following (or combinations thereof): BOD—“Beverage On Demand®” 1702 applications, services, products, and related settings, menu interfaces, content, and features.", "In at least one embodiment, the BOD Services Application may be configured or designed to provide functionality for enabling a patron to order selected items of food, beverages, and/or merchandise via interaction with one or more ODS interfaces which are presented to the patron via an EGM display.", "In at least one embodiment, the BOD Services Application may also be configured or designed to provide functionality for enabling the patron to pay for ordered items of food, beverages, and/or merchandise via interaction with one or more ODS interfaces which are presented to the patron via the EGM display.", "HOD—“Host On Demand®” 1706 applications, services, products, and related settings, menu interfaces, content, and features.", "In at least one embodiment, the HOD Services Application may be configured or designed to provide functionality for enabling a patron to contact a Casino host, and/or to request/order selected Host Service(s)/Product(s) via interaction with one or more ODS interfaces which are presented to the patron via an EGM display.", "Such functionality provides a more personalized approach as compared to the patron pressing a generic “attendant” button.", "In at least one embodiment, the patron's EGM location/information is sent to a designated host, VIP host and/or concierge via a set of configurable rules, attributes and/or criteria setup via the ODS Menu Manager Application.", "SOD—“Security On Demand®” 1704 applications, services, products, and related settings, menu interfaces, content, and features.", "In at least one embodiment, the SOD Services may be configured or designed to provide functionality for enabling a patron to contact a security official and/or a medical aid representative.", "the patron's EGM location/information is sent to a designated security and/or medical advisor via a set of configurable rules, attributes and/or criteria setup within the ODS Menu Manager Application.", "VOD—“Valet On Demand®” applications, services, products, and related settings, menu interfaces, content, and features.", "In at least one embodiment, the VOD Services may be configured or designed to provide functionality for enabling a patron to contact the valet services and notify of an estimated arrival time to have one's vehicle ready before they arrive at the vehicle pickup location.", "WOD—“Weather On Demand®” 1710 applications, services, products, and related settings, menu interfaces, content, and features.", "Reports & Data Analytics 1712 applications, services, products, and related settings, menu interfaces, content, and features.", "ODS Menu Manager Application settings 1714 and related menu interfaces, content, and features.", "Etc.", "In at least some embodiments, the On Demand Services System may be implemented as a secure network that may be comprised of numerous devices, cables, and software packages that manage information tracking between gaming machines and house/backend servers/player management/storage locations.", "In some embodiments, the On Demand Services System may display data to the patron, and receive input from the patron, via a gaming device (or mobile device) display and input interface.", "In at least one embodiment, the On Demand Services System sends received user input (as well as other data) to the backend systems via regulated messaging protocols (e.g., S2S).", "For example, in one embodiment, a patron may submit an order via an interactive button of the BOD Service menu, which, in turn, sends the order data to the backend system, whereupon one or more automated processes may process and deploy the order data to the appropriate bar/grill/location to be handled by the waitstaff.", "Aspects of the On Demand Services functionality may be implemented as an enhanced “Intelligent” Point Of Sale (POS) system that is specifically configured or designed for implementation/use at casino (or wager-based) gaming machines and/or mobile device(s) located at the casino property.", "In some embodiments, one or more of the On Demand Service menu GUI(s) may be configured or designed to be presented at an EGM via the EGM's primary display (e.g., 1022, FIG.", "10), and/or one or more auxiliary displays (e.g., 1124, FIG.", "11).", "In some embodiments, one or more of the On Demand Service menu GUI(s) may be configured or designed to be presented at an EGM via use of PIP “picture in picture” technology (e.g., NexGen, Service Window etc.", "), as found, for example, in some of IGT's, Bally's, Aristocrat, and Leap Forward Gaming's (iView/displayManager) gaming machines.", "As described in greater detail herein, the various features and functions of the On Demand Services technology provides powerful and unmatched POS flexibility for any casino environment that may be manipulated in real time (e.g., via automated processes, and/or via manual processes) while enabling one to modify the usability and layout of selected EGM interface(s) from the backend system and to upload such modifications to the floor EGMs nearly instantaneously (e.g., in real-time), all of which may be implemented without having to interrupt, halt, or otherwise interfere with the current operation(s)/activitie(s) at the floor EGMs.", "Additionally, by incorporating flexible design, the POS functionality of the On Demand Services System may function on any resolution screen across multiple brands of devices.", "Further, the On Demand Services System may be configured or designed to seamlessly integrate with existing Casino networks and systems.", "For example, in at least one embodiment, the On Demand Services System may be configured or designed to seamlessly integrate with existing casino food & beverage systems (e.g., Infogenesis, Micros), and may be configured or designed to include automated functionality for rapidly and efficiently importing existing/current/pre-built menu's into the On Demand Services System's own database system.", "In at least some embodiments, the On Demand Services System may be configured or designed to include or provide additional features/functionality such as, for example: Remembering patrons' favorite orders.", "Tracking player locations (e.g., via player tracking card in/card out).", "Notifying waitstaff of patron relocation (e.g., in real-time).", "Tracking, analyzing, generating detailed analytics and reports (e.g., promotional orders, how many clicks, how long viewed, how many ordered, real-time order status tracking, etc.).", "Generating desired heat maps.", "Providing mobile device compatibility.", "Dynamically managing, modifying, monitoring, and configuring various aspects of On Demand Service(s) such as, for example, serving periods, bar locations, printer ports, default and preferred locations for both printers and bars, waitstaff monitoring, closed loop functionality, On Demand Service menu(s) (Admin/Backend side, EGM side, Mobile, etc.", "), etc.", "Etc.", "Thus, in at least one embodiment, the On Demand Services System provides an unprecedented trackable overview of casino/patron/staff interactions, transactions, and analytics.", "Moreover, some or all of these features (as well as others not listed) may be implemented in a manner which avoids (or does not require) interrupting patron gameplay and/or wagering events.", "Thus, for example, in at least one embodiment, a patron may literally be gambling with one hand and ordering and/or requesting services with the other hand.", "As described in greater detail herein, the various On Demand features and functionality may provide a number of advantages and/or benefits which, for example, may include, but are not limited to, one or more of the following (or combinations thereof): No more waiting to get what you want while at a gaming machine.", "No more “having to sit in a populated zone” to get service.", "No more waiting in the valet line.", "Live like a VIP, and have your car ready when you step out the casino doors.", "Enjoy the comfort of knowing security and/or medical personnel may be available at the touch of a button.", "BOD, HOD, SOD, VOD, and/or WOD services are easily available and accessible via casino gaming machines and/or other devices.", "Can't see outside—how's the weather?", "No worries, you don't have to wait to find that out either.", "Simply access desired weather information at the gaming machine via the WOD Service.", "The On Demand Services technology described herein provides the new age & technological foundation that may turn the “demographic tables” in a positive and more prosperous direction by allowing players to access current amenities that are found throughout some or all of the latest and greatest websites and applications familiar in common day to day lifestyles.", "And/or other benefits, features, and advantages described and/or referenced herein.", "FIGS.", "12-16 illustrate example screenshots of various OD S graphical user interfaces (herein referred to as “Patron ODS Menu GUIs”) which may be presented to patrons via EGM displays (and/or mobile device displays), and configured or designed to enable the patron to access and/or initiate orders/requests for selected On Demand Services and/or products.", "In at least one embodiment, the example Patron ODS Menu GUIs illustrated in FIGS.", "12-16 represent examples of interactive ODS menus which may be accessed by casino patrons via a portion of an EGM display such as, for example, EGM display portion 1024 of FIG.", "10.While the example Patron ODS Menu GUIs of FIGS.", "12-16 are configured or designed to be displayed in a vertical (e.g., portrait) orientation, in other embodiment, one or more Patron ODS Menu GUIs may be configured or designed to be displayed in a horizontal (e.g., landscape) orientation, as shown, for example, at 1124 of FIG.", "11.In at least some embodiments, the On Demand Services may initially be accessed by patron interaction with a “Service” button commonly found on most gaming machines.", "In one embodiment, pressing the “Service” button causes an interactive ODS Menu GUI to be displayed (e.g., at a PIP region of the primary EGM display, as illustrated, for example, at 1024, FIG.", "10).", "According to different embodiments, the interactive OD S Menu GUI may be configured or designed to be compatible with multiple resolutions to accommodate a plurality of gaming machines and their unique resolutions and PIP configurations.", "In some embodiments, the one or more ODS Services Menu GUIs may be displayed via one or more secondary display devices at the EGM (such as, for example, NexGen, NexGenII, iView, & displayManager), thereby allowing the ODS Services Menu GUIs to be concurrently displayed at the EGM without interfering with or otherwise affecting the patron's game play (or other content) presented on the primary EGM display.", "By way of illustration, FIGS.", "55-59 illustrate example screenshots of various BOD Menu GUIs which may be presented to a given patron via an EGM display (and/or mobile device display) for enabling the patron to access and/or initiate orders/requests for selected food items, beverage items, and/or other items of merchandise.", "In at least one embodiment, the interactive ODS Menu GUI may be configured or designed to enable the user (e.g., a patron) to navigate through the various ODS services/products offered by the casino, and to access desired On Demand Services.", "Once the user has accessed the desired ODS service and has selected items/services to “order” (e.g., via ODS menu navigation, GUI interaction, swipe screens, search options, etc.", "), the user may interact with the “Submit Order” button (e.g., 5530, FIG.", "55; 5630, FIG.", "56; 5730, FIG.", "57; 5830, FIG.", "58; 5930, FIG.", "59) to cause the user's order to be submitted to the On Demand Services System for processing.", "During the processing of the submitted order, the On Demand Services System may access one or more sets of conditions/criteria which may influence or determine where the order is to be routed or delivered for further processing and/or fulfillment by casino staff.", "For example, according to different embodiments, the determination as to where a particular OD S order is to be routed for fulfillment may depend upon various criteria such as, for example, jurisdiction, regulations, house preference, patron location, time of day, day of week, availability of waitstaff, and the like.", "In some embodiments, the order data may be automatically and/or dynamically routed/outputted (e.g., in real-time) (e.g., electronically displayed and/or printed out) at a predetermined bar and/or location (e.g., in accordance with the setup/configuration implemented via the On Demand Services System's backend functionality), where the order may then be filled by servers and/or waitstaff.", "Once the order is fulfilled and ready for delivery, it may be physically up to the waitstaff to deliver the items to the identified patron who submitted the order.", "In at least some embodiments, the On Demand Services System may include functionality for dynamically tracking player locations (e.g., in real-time) and for notifying waitstaff of patron relocation.", "Thus, for example, if, while the order is being filled, the patron who ordered decides to leave the current EGM, the On Demand Services System may automatically detect this activity, and may automatically respond by initiating one or more procedures/operations such as, for example, automatically generating and sending a notification to the ODS service station (where the order is being filled) that the patron has departed from location/EGM X.", "According to different embodiments, the system may automatically determine that the player has departed from a given location/EGM in response to detecting one or more event(s) and/or conditions such as, for example: a “card out” event (e.g., where the player's player tracking card is removed from the EGM), a “ticket out” event (e.g., where the EGM generates and delivers a cash voucher to the player to zero out the EGM credit meter), a “cash out” event, etc.", "Thereafter, if the system subsequently detects that the player has carded in at location/EGM Y, the system may respond by automatically generating and sending a notification to the ODS service station (where the order is being filled) that the patron has been detected as carding in at location/EGM Y at a specific time.", "Additionally, based on the detected player movement/relocation activities, the On Demand Services System may include functionality for identifying the specific waitstaff assigned to deliver the order to the patron, and for automatically generating and sending a notification to the identified waitstaff of the patron's movement(s)/relocation.", "Thus, for example, in one embodiment, if the waitstaff is in the process of delivering the ordered drink/item to the patron, and is on the floor in route for delivery, the system may be configured or designed to automatically detect these conditions, and may automatically and dynamically initiate appropriate actions for notifying the identified waitstaff via mobile device (e.g., via text message, phone call, etc.)", "of the player's new location.", "In specific situations it may happen that an ordered ODS item is unable to be delivered to the patron (e.g., because the patron has left the EGM, because the ordered item is unavailable, etc.).", "To address such situations, the On Demand Services System may provide a time out/cancellation feature which may be configured or designed to automatically cancel the order in response to detecting the occurrence of one or more predefined set(s) of event(s)/condition(s) such as, for example: Card-out/cash-out/ticket-out event detected at EGM where OD S order originated.", "Location of patron who ordered item cannot be detected, verified and/or determined.", "Ordered item unavailable.", "Condition(s) for allowing fulfillment of order no longer met/satisfied.", "Player no longer wagering at required minimum allowable wager amount/level for receiving ordered item.", "And/or other set(s) of event(s)/condition(s) as may be configured/defined by the casino.", "In addition to automatically canceling the order, the On Demand Services System may be configured or designed to identify and notify appropriate casino personnel (e.g., staff assigned to handle the order) that the identified ODS order has been cancelled.", "In at least some embodiments, the On Demand Services System may be configured or designed to include functionality for enabling waitstaff personnel to submit orders on behalf of the patron via a mobile device, smartphone and/or tablet running ODS application(s).", "In at least some embodiments, the mobile ODS applications/GUIs may be configured or designed to include functionality similar to that of the OD S Service menu GUIs described herein.", "Additionally, in at least some embodiments, similar triggering events/conditions/criteria may be applied to ODS orders placed by waitstaff on behalf of casino patrons.", "On Demand Service Menu GUI Configuration One of the beneficial aspects of the On Demand Services technology described herein relates to the flexible nature of the On Demand Service menu GUI configuration and layout.", "For example, in at least one embodiment, a casino property may configure different On Demand Service menu GUIs to offer different items in different ways.", "By way of illustration, to order a cup of coffee, an On Demand Service menu GUI may be configured to display (e.g., via the EGM display interface) a “Coffee” button.", "When the player selects the Coffee Button, the system may display a list of condiments (e.g., cream, sugar, Splenda, etc.)", "to the player, and request that the user select the specific condiments which the player would like to have included with the order.", "Alternatively, one or more On Demand Service menu GUI(s) may be configured or designed to include multiple different “Coffee” buttons such as, for example: “Coffee—black”, “Coffee—with cream”, “Coffee—with cream and sugar”, etc.", "The customization, layouts, configurations, and content of the On Demand Service menu GUI(s) may be controlled and managed by the casino property.", "Additionally, in at least some embodiments, the On Demand Services System may include functionality for enabling the On Demand Service menu GUI(s) to automatically and/or dynamically modified based on feedback from the customers/patrons, thereby allowing for instant changes to fully maximize player services and comfort.", "As described in greater detail herein, the On Demand Services System may include a Front End subsystem (e.g., enabled at EGMs, and Mobile Platform(s), for use by customers, patrons, waitstaff, etc.)", "and a Back End subsystem (e.g., implemented at a Casino server, accessible by authorized casino personnel).", "Examples of various types of Frontend activities which a casino patron (and/or waitstaff) may perform by interacting with one or more of the ODS Menu GUIs presented via an EGM (or mobile device) display may include, but are not limited to, one or more of the following (or combinations thereof): Beverage On Demand Services, such as, for example: Order items Leave comments Select favorites Select promotional items Move to different EGM's while order is in process (Player Tracking Card In/Card Out) Play EGM and order items simultaneously Security On Demand Services, such as, for example: Contact Security personnel Contact Medical personnel Contact Property personnel Play EGM and contact personnel simultaneously Host On Demand Services, such as, for example: Contact Host and/or VIP Host Contact Concierge Play EGM and contact personnel simultaneously Valet On Demand Services, such as, for example: Notify Valet Personnel on expected vehicle pickup Inform Valet Personnel on estimated time of arrival Supply Valet Coupon and/or ticket number for ease of use Play EGM and contact personnel simultaneously Weather On Demand Services, such as, for example: Stay up to date with current (local) weather and predicted forecasts Find global weather and forecasts via search engine Play EGM and be informed and/or search simultaneously Examples of various types of data and/or information which may be accessed, monitored, and/or modified by casino employees (and/or other authorized users) interacting with one or more of the On Demand Service window GUIs presented via a backend system display may include, but are not limited to, one or more of the following (or combinations thereof): Central access to individual On Demand applications and functionality thereof (e.g., AppSite) Menu Management interface system (Beverage On Demand), which, for example, may provide access to various types of Beverage On Demand related information such as, for example: Primary Categories Sub Categories Items Category Condiment & Condiment Group categories Custom Item images Custom Language setup Limit Tags, Limit Item Amounts & Limit Patrons Serving Periods, Bars & Printer locations Receipt formats Ads, Pop-up ads, and Banner Ads Discounts, promotions (based on tier, age, gender, birthday, other) Waitstaff management Tiered functionality Micros Integration Infogenesis Integration Analytics Player Tracking (Card In/Card Out) Heat Maps Intelligent Favorites Enable/Disable patron order comments Report management Export Database Closed Loop System Security Management interface system (Security On Demand), which, for example, may provide access to various types of Security On Demand related information such as, for example: General Setup Security Setup Medical Setup Reports Host Management interface system (Host On Demand), which, for example, may provide access to various types of Host On Demand related information such as, for example: General Setup Host Setup Reports Valet Management interface system (Valet On Demand), which, for example, may provide access to various types of Valet On Demand related information such as, for example: General Setup Valet Setup Reports Weather Management interface system (Weather On Demand), which, for example, may provide access to various types of Weather On Demand related information such as, for example: General Setup Report Management interface system (Report Management), which, for example, may provide access to various types of Report Management related information such as, for example: Order Tracking Delete Orders Generate Report Location Date Items Player Saving Examples of various types of Backend activities which casino employees (and/or other authorized users) may initiate and/or perform by interacting with one or more of the On Demand Service window GUIs presented via a backend system display may include, but are not limited to, one or more of the following (or combinations thereof): Central access to individual On Demand applications and functionality thereof (AppSite).", "Menu Management interface system (Beverage On Demand), which, for example, may provide access to various types of BOD related features, functions, operations such as, for example, one or more of the following (or combinations thereof): Configurable drag & drop Primary Categories Configurable drag & drop Sub Categories Configurable drag & drop Items Category Configurable drag & drop Condiment & Condiment Group categories Configurable custom Item images Configurable Limit Tags, Limit Item Amounts & Limit Patrons Configurable Serving Periods, Bars & Printer locations Configurable Receipt formats Configurable Ads, Pop-up ads, and Banner Ads Configurable discounts, promotions based on tier, age, gender, birthday, other Configurable Waitstaff management (with pin number for closed loop system) Tiered functionality (based through multiple sections) Micros Integration (menu database import) Infogenesis Integration (menu database import) Analytics (viewing and printing) Heat Maps (viewing and printing) Enable/Disable patron order comments Report management (viewing and printing).", "Security Management interface system (Security On Demand), which, for example, may provide access to various types of SOD related features, functions, operations such as, for example, one or more of the following (or combinations thereof): General Setup email port alert port SMTP server username account password protection language select Security Setup Email SMS Printer Email receiver Phone number receiver Phone service provider Add service provider Printer receiver Medical Setup Email SMS Printer Email receiver Phone number receiver Phone service provider Add service provider Printer receiver Reports Call type Report type Host Management interface system (Host On Demand), which, for example, may provide access to various types of HOD related features, functions, operations such as, for example, one or more of the following (or combinations thereof): General Setup email port alert port SMTP server password protection language select Host Setup Email SMS Printer Reports Report type Date setup Filter Reports Valet Management interface system (Valet On Demand), which, for example, may provide access to various types of VOD related features, functions, operations such as, for example, one or more of the following (or combinations thereof): General Setup email port alert port SMTP server username account password protection language select Valet Setup Email SMS Printer Email receiver Phone number receiver Phone service provider Add service provider Printer receiver Reports Report type Date setup Filter Reports Weather Management interface system (Weather On Demand), which, for example, may provide access to various types of WOD related features, functions, operations such as, for example, one or more of the following (or combinations thereof): General Setup Default Language Favored Country Default Location Measurement System API Key Report Management interface system (Report Management), which, for example, may provide access to various types of Report Management related features, functions, operations such as, for example, one or more of the following (or combinations thereof): Order Tracking Delete Orders Generate Report Location Date Items Player Saving In at least some embodiments, each of the different types of On Demand Services may have associated therewith a respective set of management GUIs for enabling casino staff, administrators and/or other authorized personnel to access, configure, monitor, modify, analyze, and report various types of On Demand related activities, events, data, and/or other information.", "Moreover, in at least some embodiments, these activities may be performed or accessed in real-time (e.g., on the fly), without causing or requiring any disruption to any concurrent or existing gaming-related and/or wagering-related activities being conducted via the casino gaming network, and without requiring that the On Demand Services System be brought off-line.", "It will be appreciated that On Demand Services techniques have been configured or designed to overcome various technological issues and limitations which have existed with respect to many of today's on-demand service systems which are currently deployed at casino properties.", "For example, the customized features and content of many on-demand service systems which are currently deployed at one or more casino properties are typically implemented via use of hardcoded software which has been specifically customized and configured to accommodate the individual requirements of each separate casino.", "In order to modify or change the features, content, or GUIs of such hardcoded on-demand systems, it is typically necessary to require that the systems running the on-demand services be brought off-line in order to implement the desired modifications.", "This may also cause or result in a disruption of gaming-related and/or wagering-related activities being conducted via the casino gaming network.", "In contrast, embodiments of the On Demand Services System described herein are specifically configured or designed to be implemented using flexible-based software coding techniques which provide functionality for enabling the features, content, and/or GUIs of On Demand Services System(s) to be dynamically configured, re-configured, or otherwise modified in real-time (e.g., on the fly), without causing or requiring any disruption to any concurrent or existing gaming-related and/or wagering-related activities being conducted via the casino gaming network, and without requiring that the On Demand Services System be brought off-line in order to implement such changes/modifications.", "Example Beverage on Demand (BOD) Services Features and Management FIGS.", "12, 55-59 illustrate example screenshots of various BOD Service Menu GUIs which may be accessed via the frontend system by patrons and/or waitstaff (e.g., via EGM device and/or mobile device).", "The example screenshots of BOD Service Menu GUIs illustrated in FIGS.", "12, 55-59 have been specifically configured for vertical-oriented presentation on a portion of an EGM display, as illustrated, for example, at 1024 of FIG.", "10.In other embodiments (not shown) the BOD Service Menu GUIs for horizontal-oriented presentation, and/or may be configured for presentation on other types of displays such as, for example, mobile devices, smart phones, PDAs, kiosk displays, etc.", "As described in greater detail herein, the Beverage On Demand® (BOD) Menu GUIs may be configured or designed to enable patron and/or waitstaff to browse the catalog of available items which may be ordered via the casino's BOD Service, select desired item(s) to be ordered, and submit an order for the selected items to the casino's BOD Service.", "In at least some embodiments, the BOD Service System may also be configured or designed to enable the patron to pay for the BOD Service order via one or more different types of funding sources such as, for example, credit cards, ATM cards, PayPal™, bitcoins, casino credits, casino vouchers, coupons, cash, room charge, etc.", "According to the preferences of the casino, the BOD Service Menu GUI(s) may be configured or designed to offer a variety of different items for ordering, including, for example, one or more of the following (or combinations thereof): food items, beverage items, novelty items, gift shop accessories, etc.", "However, for purposes of illustration and ease of explanation, the BOD Service Menu GUI(s) illustrated and described with respect to FIGS.", "12, 30-49, and 55-59, focus primarily on beverage items which may be available for ordering via the BOD Service Menu GUI(s).", "According to different embodiments, some of items offered via the BOD Service Menu GUI(s) may be available for purchase, while other items offered via the BOD Service Menu GUI(s) may be available for complimentary ordering (e.g., for a given patron).", "For example, in some embodiments the On Demand Services System may be configured or designed to include functionality for automatically monitoring casino patron gaming/wagering activities, and for automatically “comping” food, beverages, and/or other items ordered by a given patron via the BOD Service in response to determining that specific predefined conditions, events, and/or criteria have been satisfied.", "According to different embodiments, at least a portion of such predefined conditions, events, and/or criteria may be based on one or more of the following (or combinations thereof): Player Identity.", "Gaming history of that player at the player's current EGM.", "Gaming history of that player over a designated time interval.", "Wagering history of that player at the player's current EGM.", "Wagering history of that player over a designated time interval.", "Current physical location of the player.", "Historical physical location of player over one or more time intervals (e.g., player must be physically located on the gaming floor for at least 15 consecutive minutes in order to receive a free comp drink).", "And/or other desired criteria as may be configured/defined by the casino.", "By way of illustration, the casino may configure the On Demand Services System to allow a player at an EGM to order (via BOD Service Menu GUI) a complementary “top shelf” mixed drink once every 15 minutes, provided that the player initiates at least 10 wagers at the EGM each 15 minutes, and provided that each wager is a minimum of $1.In one embodiment, the On Demand Services System may be configured or designed to not allow the player to place an order for a complementary “top shelf” mixed drink until all required conditions/events are satisfied.", "In another embodiment, the player may start a gaming session at the EGM and specify a wager/bet amount of $1.Before the 15 minutes has elapsed, the On Demand Services System may be configured or designed to permit the player to place submit a “top shelf” mixed drink order before all required conditions/events are satisfied, but may continue to proactively monitor the player's wagering activities, and may take appropriate action to automatically cancel the order if the system subsequently detects that the player has switched to a $0.50 wager/bet amount, for example.", "FIG.", "12 shows an example screenshot of a BOD Main Menu GUI 1200, in accordance with one embodiment.", "As illustrated in the example embodiment of FIG.", "12, the BOD Main Menu GUI includes a first portion of interactive content 1210, which is configured or designed to enable the user (e.g., casino patron) to browse through a catalog of various types of beverages (e.g., beer, mixed drinks, nonalcohol beverages, wine, etc.)", "which are available to be ordered via the casino's BOD Service.", "The BOD Main Menu GUI may also include additional interactive content (e.g., 1220) which may be configured or designed to include functionality for enabling the patron to perform additional tasks relating to the BOD Service, such as, for example for example, one or more of the following (or combinations thereof): View/order/purchase special offers and/or promotions.", "Submit an order.", "Review items in the electronic shopping cart.", "Navigate to other menus of the BOD Service.", "Access other On Demand Services.", "Request a casino attendant.", "Request a server (e.g., waiter/waitress).", "Check on the status of a pending BOD order.", "Cancel a submitted BOD order.", "Modify a BOD order which has been submitted.", "Select/change default language of BOD Menu GUI(s).", "Initiate a keyword search for specific items.", "Minimize the BOD Service Menu.", "Close the BOD Service Menu.", "And/or other types of activities illustrated or described herein.", "FIG.", "55 shows an example screenshot of a BOD Menu GUI 5500, illustrating an example embodiment of a promotional offer (e.g., Budweiser Beer) being displayed via a pop-up window or overlay layer 5510.In one embodiment, the user may add the promotional item to the user's electronic shopping cart (e.g., by tapping on “+” icon 5511, and/or may order the promotional item by sliding the virtual “slide” button 5530 in the direction indicated.", "FIG.", "56 shows an example screenshot of a BOD Main Menu GUI 5600 which has been configured or designed to display promotional offer content 5620 (e.g., daiquiri mixed drink $5.99).", "In one embodiment, the user may add the promotional item to the user's electronic shopping cart, and/or may directly submit an order for the promotional item via interaction with “Submit Order” GUI portion 5630.Additionally, as illustrated in the example embodiment of FIG.", "56, the BOD Main Menu GUI may include interactive content 5610 for enabling the user to access one or more BOD submenus relating to the different types of of beverages (e.g., beer, mixed drinks, nonalcohol beverages, wine, etc.)", "which are available to be ordered via the casino's BOD Service.", "FIG.", "57 shows an example screenshot of a BOD Submenu GUI 5700, in accordance with one embodiment.", "As illustrated in the example embodiment of FIG.", "57, the BOD Submenu GUI 5700 has been configured to represent a BOD Beer Menu which displays information (e.g., 5720) about various types of beer (e.g., light beers, dark beers, wheat bears, pale ales, etc.", "), brands of beer (e.g., Budweiser, Coors, Stella, etc.", "), and/or items of beer (e.g., 12 oz can of Coors, 10 oz bottle of Budweiser, etc.)", "that are available for ordering via the BOD Service.", "Additionally, as illustrated in the example embodiment of FIG.", "57, BOD Submenu GUI 5700 has been configured or designed to display promotional offer content 5720 (e.g., Margarita mixed drink $5.99).", "In one embodiment, the user may add one or more of the offered items to the user's electronic shopping cart, and/or may directly submit an order for the promotional item via interaction with “Submit Order” GUI portion 5730.In at least one embodiment, the user may access the BOD Beer Menu of FIG.", "57 by tapping or selecting the “Beer” line item (e.g., 5612) of the BOD Main Menu GUI of FIG.", "56.FIG.", "58 shows an example screenshot of a BOD Submenu GUI 5800, in accordance with one embodiment.", "As illustrated in the example embodiment of FIG.", "58, the BOD Submenu GUI 5800 has been configured to represent a BOD Item Menu which displays additional information (e.g., 5810) about one or more specific BOD items (e.g., can of Stella beer).", "In at least one embodiment, the user may add (e.g., 5811) one or more of the offered items to the user's electronic shopping cart, and/or may directly submit an order for the promotional item via interaction with “Submit Order” GUI portion 5830.In at least one embodiment, the user may access the BOD Item Menu of FIG.", "58 by tapping or selecting the “STELLA” line item (e.g., 5712) of the BOD Beer Menu of FIG.", "57.FIG.", "59 shows an example screenshot of a BOD Shopping Cart GUI 5900, in accordance with one embodiment.", "As illustrated in the example embodiment of FIG.", "59, the BOD Shopping Cart GUI 5900 has been configured to provide the user with access to various types of information and features relating to the selected BOD items which the user has added to his electronic shopping cart via interaction with one or more BOD Menu GUI(s).", "By way of illustration, examples of such information/features may include, but are not limited to, one or more of the following (or combinations thereof): Listing of individual items (e.g., 5912, 5914) which have been added to the user's electronic shopping cart.", "Item pricing information.", "Tax-related information.", "(e.g., 5916) Functionality for enabling the user to dynamically add/subtract/modify/remove quantities of selected items to/from the user's shopping cart.", "Functionality for enabling the user to add special request(s) relating to one or more items in the user's shopping cart.", "Functionality 5918 for enabling the user to add one or more comment(s) to the BOD order.", "Functionality 5930 for enabling the user to submit the BOD order.", "Functionality for enabling the user to pay for the BOD order.", "Functionality for enabling the user to apply comps, coupons, discounts to the BOD order.", "And/or other types of information and/or functionality described herein.", "Real-Time BOD/ODS Tracking Functionality It is noted that many of today's on-demand service systems which are currently deployed at casino properties are not configured or designed to provide casino management with access to real-time tracking of orders which have been submitted to their on-demand service systems.", "Some reasons why such functionality has typically not been provided by such prior on-demand service systems relate to the complex and proprietary nature of the casinos networks.", "Additionally, since the customized features and content of many currently deployed on-demand service systems are typically implemented via use of hardcoded software, such systems inherently lack the dynamic customization/configuration flexibility which may be required for implementing real-time tracking of on-demand service orders.", "Accordingly, as described in greater detail herein, it may be appreciated that some of the unique and advantageous features of the presently described On Demand Services System relate to the system's ability to automatically track (e.g., in real-time) the current status of all BOD orders (and/or other types of ODS orders) which have been submitted to the On Demand Services System, and to the system's ability to provide casino personnel (and/or other authorized personnel) with access to real-time status information relating to specific orders and/or specific types of orders (e.g., pending orders, new orders, delivered orders, canceled orders, delayed orders, complementary orders, etc.).", "FIGS.", "60-64 illustrate example screenshots of various BOD Service Tracking GUIs which may be used for accessing real-time BOD tracking functionality relating to BOD Services and other related information/features, including, for example, one or more of the following (or combinations thereof): Real-time tracking of pending BOD Service orders.", "(e.g., FIG.", "61) Real-time tracking of delivered BOD Service orders.", "(e.g., FIG.", "62) Real-time tracking of canceled BOD Service orders.", "(e.g., FIG.", "63) Configuration of features and default settings relating to the BOD Service.", "(e.g., FIG.", "64) Etc.", "In at least one embodiment, at least a portion of the BOD tracking functionality may be provided by a BOD Tracking System, which, for example, may be implemented as a component or subsystem of the On Demand Services System.", "In the specific example embodiments of FIGS.", "60-64, the example BOD Service Tracking GUIs have been configured for presentation on a computer system display (such as, for example, a desktop computer, laptop computer, mobile device, etc.", "), and may be accessed via use of a web browser application.", "In other embodiments (not shown) the one or more of the BOD Service Tracking GUIs may be accessed via a client application running on a remote system.", "FIG.", "60 shows an example screenshot of a BOD Login GUI 6000 which may be used by authorized persons for accessing tracking functionality for the BOD Service.", "In order to access the main contents of the tracking system, a secure pin pad login may be required.", "The pin may be setup through the ODS System.", "FIG.", "61 shows an example screenshot of a BOD Order Tracking GUI 6100 which may be configured or designed to include functionality for enabling authorized personnel to access real-time BOD tracking of the various BOD orders which have been submitted to the BOD System, including, for example, one or more of the following (or combinations thereof): Pending or open BOD orders (e.g., 6112).", "New and/or recent BOD orders.", "Delivered BOD orders (e.g., 6114).", "Canceled BOD orders (e.g., 6116).", "Delayed BOD orders.", "Etc.", "In the example embodiment of FIG.", "61, the BOD Order Tracking GUI 6100 has been configured to display pending BOD orders, which may be accessed by tapping or selecting the “Pending Orders” (6112) display option.", "As illustrated in the example embodiment of FIG.", "61, two BOD orders (e.g., 6122, 6124) are currently pending.", "Display of various different icons (e.g., 6121, 6123, 6125, 6127) may be used to denote (e.g., via quick visual observation) aspects about each order such as, for example, one or more of the following (or combinations thereof): new order not yet viewed before; order which has been previously viewed; whether the player is currently seated/carded out/carded in; player VIP status; and/or other aspects and/or information about a given order.", "In one embodiment, each order that comes in may be displayed within its own respective window and/or frame (e.g., 6122, 6124) of the BOD Order Tracking GUI, and within each configurable window/frame, information about that specific order is displayed such as, for example, one or more of the following (or combinations thereof): player id; player name; time when order placed; elapsed time since order was placed; item description(s); order number; zone; location; EGM bank; pricing information; payment method; etc.", "In one embodiment, if the population of the orders expands beyond the screen display resolution limits, a scroll bar may automatically appear, allowing the user to scroll through the order list.", "As illustrated in the example embodiment of FIG.", "61, a Bar/Section Selection Icon 6102 may be displayed for enabling the user to switch between different bars, restaurants, zones/sections, and/or other locations where BOD orders may be processed, filled, or prepared.", "Additionally, as illustrated in the example embodiment of FIG.", "61, the BOD Order Tracking GUI may include a printer icon (e.g., 6106) for enabling the user to send print outs of selected orders to one or more selected printer locations at the casino property.", "In at least one embodiment, the BOD Order Tracking GUI(s) may be configured or designed to include keyword searching functionality (e.g., 6108) and grouping functionality for enabling users to view real-time status details relating to one or more sets of orders which match user-defined search criteria such as, for example, one or more of the following (or combinations thereof): Employee ID, Player ID, EGM ID, zone, EGM location, Player location, Bar/Restaurant ID, BOD item, BOD order ID, time-based criteria (e.g., range of time, range of day(s), range of date(s), etc.)", "and/or other types of searchable or filterable criteria.", "For example, in the specific example embodiment of FIG.", "61, the BOD Order Tracking GUI 6100 displays status details of pending BOD (e.g., 6120) orders which have been assigned to a specifically identified employee (e.g., Emp: #112244) (6104).", "In at least one embodiment, this grouping functionality may be used to help keep orders in their respective server zones and associated with their respective servers.", "FIG.", "62 shows an example screenshot of a BOD Order Tracking GUI 6200 which has been configured or designed to provide user access to real-time BOD tracking information relating to delivered BOD orders.", "In the specific example embodiment of FIG.", "62, the BOD Order Tracking GUI 6200 displays status details of a set of delivered BOD orders (e.g., 6220) which are associated with a specifically identified employee (e.g., Emp: #112244).", "FIG.", "63 shows an example screenshot of a BOD Order Tracking GUI 6300 which has been configured or designed to provide user access to real-time BOD tracking information relating to canceled BOD orders.", "In the specific example embodiment of FIG.", "63, the BOD Order Tracking GUI 6300 displays status details of a set of canceled BOD orders (e.g., 6320) which are associated with a specifically identified employee (e.g., Emp: #112244).", "In at least one embodiment, the On Demand Services System may include functionality for populating and maintaining an ODS Order Database for storing all (or selected) details of all (or selected) historical ODS orders, status updates, and related transactions.", "In one embodiment, the ODS Order Database may provide searchable access to archive-based lists of ODS orders, status updates, and related transactions which may be utilized by the BOD Tracking System (and/or other components/systems) for providing various aspects of the real-time BOD tracking and reporting functionalities described herein.", "Any order that is cancelled and/or delivered will populate these tabs.", "FIG.", "64 shows an example screenshot of a BOD Tracking Configuration GUI 6400 which may be configured or designed to include functionality for enabling authorized personnel to configure and/or modify various aspects/features relating to the BOD Tracking System functionality and/or BOD Order Tracking GUI(s).", "In at least one embodiment, one or more BOD Tracking Configuration GUI(s) may be configured or designed to enable authorized user(s) to selectively and/or dynamically set and/or modify configuration parameters of the BOD Tracking System such as, for example: the automated closing of orders (e.g., 6410); default settings (e.g., 6420), etc.", "For example, as illustrated in the example embodiment of FIG.", "64, a user may check the box in the “Close Orders When Printed” configuration GUI 6410 to configure the BOD Tracking System to automatically close an identified order in the BOD system after the order has been printed from the BOD Order Tracking GUI.", "Alternatively, a user may check the box in the “Close Orders When Printed” configuration GUI 6410 to configure the BOD Tracking System to prevent a printed order from being automatically closed.", "In this latter configuration, the order may need to be closed using the Service Window of the carded patron (or using the Mobile Close Loop screen when using Intelligent BOD).", "Additionally, as illustrated in the example embodiment of FIG.", "64, as shown at 6420, a user may selectively configure a selected bar of the casino (e.g., Bar_T1) as the “Default Bar” parameter of one or more BOD Order Tracking GUI(s).", "In at least one embodiment, different BOD Tracking System terminals may each be separately configured to have a respective Default Bar parameter assigned thereto.", "In at least some embodiments, the default bar parameter assigned to a first BOD Tracking System terminal may differ from another default bar parameter assigned to a second BOD Tracking System terminal.", "Thus, for example, as illustrated in the example embodiment of FIG.", "64, the casino bar identified as “Bar_T1” may be configured as the Default Bar for the BOD Tracking System terminal which is displaying the BOD Tracking Configuration GUI 6400.BOD Menu Management and Configuration One of the beneficial aspects of the On Demand Services technology described herein relates to the flexible nature of the ODS Menu GUI configurations and layouts, which provide functionality for enabling the features, content, and/or GUIs of On Demand Services System(s) to be dynamically configured, re-configured, or otherwise modified in real-time (e.g., on the fly), without causing or requiring any disruption to any concurrent or existing gaming-related and/or wagering-related activities being conducted via the casino gaming network, and without requiring that the On Demand Services System be brought off-line in order to implement such changes/modifications.", "In at least one embodiment, such functionality may be implemented via use of a Menu Manager (MM) System, which may be configured or designed to enable authorized users to dynamically configure and/or modify selected features, content, and/or GUIs of On Demand Services System(s).", "In at least one embodiment, the Menu Manager System may be implemented as an application, component or subsystem of the On Demand Services System.", "In some embodiments, the Menu Manager System may be implemented as a separate system which is configured or designed to provide ODS Menu Management functionality via remote access to the On Demand Services System.", "FIGS.", "30-49, and 60-64 illustrate example screenshots of BOD Menu Manager GUIs which may be accessible by authorized casino staff or other authorized entities.", "More specifically, FIGS.", "30-49 illustrate example screenshots of various backend BOD Service GUIs which may be used for accessing, enabling, initiating, and/or performing one or more of the following operation(s), action(s), and/or feature(s) (or combinations thereof): Configuring the features, content and other aspects of the frontend BOD Service Menu GUIs Configuring the features, content and other aspects of the backend BOD Service GUIs Configuring the features, content and other aspects of the BOD Service Accessing the BOD Reporting and Tracking features of the BOD Service Accessing specific features of the BOD Service System which are available for use by approved administrators and/or managers.", "Etc.", "As described previously with respect to FIGS.", "17 and 18, the On Demand Services System may include a Menu Manager application which is configured or designed to provide functionality for enabling authorized personnel to fully customize and configure On Demand Services menus, sub-menus, and related GUIs.", "In at least one embodiment, the ODS Menu Manager Application enables authorized users (such as, for example, Casino Management and/or Food & Beverage Directors) to access, edit, customize, and/or modify selected On Demand Service application(s) menus, sub-menus and GUIs (e.g., BOD, HOD, SOD, VOD, WOD, Reports, etc.).", "In at least one embodiment, such authorized personnel may use the OD S Menu Manager Application to implement desired configurable updates and/or changes to one or more of the On Demand Service application(s) menus, sub-menus and GUIs, to thereby fully customize the services, features, and content provided by the On Demand Services System in a manner which conforms with the specific needs and/or desires of each individual property (e.g., casino property).", "FIG.", "18 shows an example embodiment illustrating how the ODS Menu Manager Application may be configured or designed to function as an admin management hub for managing On Demand products and services.", "FIG.", "17 shows an example screenshot of an ODS Menu Manager Application GUI 1700 which has been configured or designed to provide authorized users with access to various On Demand applications, services, products, and their related menu interfaces, content, and features.", "FIG.", "30 illustrates an example screenshot of a BOD Menu Manager-Main Menu GUI which may be configured or designed to function as an admin management hub for managing and/or configuring BOD Service features and/or BOD Menu GUIs.", "As illustrated in the example embodiment of FIG.", "30, the BOD Menu Manager-Main Menu GUI may be divided into multiple sections or “panels.” (e.g., 3050, 3060, 3080, 3090, etc.)", "On the left is the “Navigation Panel” 3050 that is configured to display a plurality of user selectable “BOD Navigation” buttons (e.g., 3001, 3002, 3004, 3006, 3008, 3010, 3012, 3014, 3016, 3018, 3020, etc.)", "that enable the user to navigate, select and/or configure various aspects, features, and/or content of BOD Service Menu GUI(s), including, for example, one or more of the following (or combinations thereof): BOD Service Menu features/parameters/content 3001; Promotion features/parameters/content 3002; Bars features/parameters/content 3004; Serving Period features/parameters/content 3006; Waitstaff features/parameters/content 3008; EGM's features/parameters/content 3010; Ads features/parameters/content 3012; Tax features/parameters/content 3014; Limits features/parameters/content 3016; Configure features/parameters/content 3018; Reports features/parameters/content; Export features/parameters/content 3020; Etc.", "The Content Panel GUI portion 3040 shows the various configurable options that are available in connection with each BOD Navigation button of the Navigation Panel 3050.In at least one embodiment, the panel sections may be configured or designed to provide a familiar user interface where the BOD navigation elements (e.g., 3050) remain in their same (or similar) relative locations (e.g., throughout configuration use), and where the Content Panel GUI portion 3040 is where the dynamically changeable configurations are implemented by the user.", "In this way, the user quickly becomes familiarized with the layout and functionality of the Menu Manager Application GUI(s).", "By way of illustration, referring to FIG.", "30, as the user selects different BOD navigation buttons of the Navigation Panel 3050, the content displayed in the Content Panel GUI portion 3040 automatically and dynamically changes in accordance with the currently selected BOD navigation button.", "For example, in the specific example embodiment of FIG.", "30, it is assumed that the MENU navigation button 3001 is currently selected.", "Accordingly, the MM Application may respond by dynamically displaying (at the Content Panel GUI portion 3040) configurable aspects/parameters relating to the BOD Service Menu GUI(s), such as, for example, one or more of the following (or combinations thereof): Primary Menu Categories 3011; Sub Menu Categories 3013; BOD Menu Items 3015; Condiment Items 3070; Condiment Groups 3080 (e.g., which may be associated with respective BOD Menu Categories, Sub-categories and/or items); Main Menu GUI layout/features/content 3090; Sub Menu GUI layout/features/content; Item Menu GUI layout/features/content; And/or other aspects/features of the BOD Service described or referenced herein.", "Moreover, because the On Demand Services System may be configured or designed to provide dynamically configurable/updatable inventory and interface management features using easy “drag and drop” work flow functionality, the system is able to offer levels of flexibility and adaptability which may conform with the needs/desires of most any type of business (e.g., casino property), theme, marketing campaign, etc.", "Menu Content Panel GUI 3040 may be configured or designed to provide configurable access for some or all of the Condiment Groups, Condiments, Categories, Sub Categories, and/or orderable Items of the BOD Service.", "In at least one embodiment, the MM Application may also provide a “Preview Menu” feature that offers how the menu may look when displayed at an EGM.", "The Content Panel section herein provides the means necessary to create, configure and/or modify the BOD Menu GUIs that are to be used by the BOD Service.", "Menu Condiment Groups GUI portion 3080 may be configured or designed to enable a user to define, configure, and/or modify different groups of condiments and associated parameters.", "In at least one embodiment, condiment groups are a way to categorize various condiment items that may accompany different types of BOD menu items.", "For example, a condiment group named “Burgers” may be created and associated with all Burger-type items of the BOD menu.", "In one embodiment, the Burger condiment group may be configured to include selected condiment items such as, for example: ketchup, mustard, pickles, lettuce, onions, etc.", "In at least one embodiment, individual condiment items may be defined, configured, and/or modified via the Condiment Item GUI portion 3070.In at least one embodiment, the Menu Condiment Groups GUI portion 3080 and/or Condiment Item GUI portion 3070 may be configured or designed to include functionality for enabling a user to: add/create/modify/delete one or more condiment group(s) (e.g., 3081); add/create/modify/delete one or more condiment item(s) (e.g., 3071); assign selected condiment item(s) to one or more condiment group(s); edit/modify/add/delete associations between condiment item(s) and condiment group(s); configure specific condiment item(s) and/or condiment group(s) as being required (e.g., “R”), optional (e.g., “O”), and/or additional (e.g., “A”) edit/modify/add/delete descriptions of selected condiment item(s) and/or condiment group(s); and/or other functionality described and/or referenced herein.", "As illustrated in the example embodiment of FIG.", "30, edit icons (e.g., 3063, 3073, 3083, etc.)", "may be displayed in connection with various menu items and/or groups for enabling a user to selectively modify/re-configure (e.g., individually and/or in batch) desired aspects, features, and/or content associated therewith.", "FIG.", "31 illustrates an example screenshot of a BOD New Condiment Group GUI 3100 which may be configured or designed to facilitate the user in creating and configuring a new condiment group.", "In at least one embodiment, different types of condiment groups may be respectively defined and configured based on different types of food categories/items.", "For example, as illustrated in the example embodiment of FIG.", "31, it is assumed that the user is creating a new condiment named “French Fries” 3112.In this particular couple, it is further assumed that at least two specific condiment items (e.g., ketchup 3122, vinegar 3124) have been assigned to the French Fries condiment group as a required condiment to be included with all French Fry orders serviced by the BOD System.", "In one embodiment, when casino patron orders a “Basked of French Fries” via an EGM's BOD Service Menu GUI, the BOD System may automatically and dynamically determine that the “French Fries” condiment group is associated with the BOD menu item: “Basked of Fries”, and may respond by automatically and dynamically offering (e.g., via the EGM On-Demand Service GUI) the patron the option of adding ketchup and/or vinegar as condiments the “Basked of French Fries” order.", "Alternatively, the system may respond by taking appropriate action to automatically and dynamically add or append the “French Fries” condiment group items (e.g., ketchup, vinegar) to the “Basket of Fries” BOD order.", "In at least one embodiment, the identified condiments of ketchup and vinegar may be listed on the BOD order ticket (e.g., which may be used by the entity preparing the BOD order and/or may be used by the waitstaff delivering the order) as condiment items which are required to be included with the Basket of Fries order.", "Additionally, in some embodiments, the system may automatically identify the waitstaff who is assigned to deliver the order to the patron, and may automatically notify the identified waitstaff (e.g., via mobile device, printout, workstation display) to supply ketchup and vinegar as condiments when serving the Basket of Fries order.", "In one embodiment, menu item and group names may be allowed to have (up to) 32 characters each.", "In some embodiments, errors may be displayed if multiple items and/or groups share the same name.", "In at least some embodiments, additional fields may be provided in one or more BOD Menu GUIs for use in displaying items/content of the BOD Menu GUIs in other languages.", "In at least some embodiments, the MM Application may be configured or designed to provide “drag & drop” functionality for facilitating configuration of one or more BOD Service Menu(s).", "Illustrative examples of such “drag & drop” functionality are illustrated and described, for example, with respect to FIGS.", "32, and 37-39.FIG.", "32 illustrates an example screenshot of a BOD Condiment Group Configuration GUI 3200 which may be configured or designed to facilitate a user in configuring associations between various condiment items and condiment groups.", "For example, as illustrated in the example embodiment of FIG.", "32, the Condiment Group Configuration GUI includes a Condiment Item GUI portion 3220 which may be populated with various types of BOD condiment items (e.g., Ice 3222).", "Additionally, the Condiment Group Configuration GUI also includes a Condiment Group GUI portion 3210 which may be populated with various types of BOD condiment groups (e.g., Non-Alcoholic Beverages 3122).", "As illustrated in the example embodiment of FIG.", "32, the Condiment Group Configuration GUI may be configured or designed to provide “drag & drop” functionality (e.g., as illustrated within the outlined region 3240) for facilitating a user in configuring associations between various condiment items and condiment groups.", "In this particular example, it is assumed that a user is using the GUI's “drag & drop” functionality to add the selected condiment item: ICE to the condiment group: NON-ALCOHOL BEV.", "In at least one embodiment, this may be achieved by selecting and holding the displayed “ICE” object 3222 (e.g., using computer mouse or touchscreen display), dragging a representation of the “ICE” object until it is positioned over the “NON-ALCOHOL BEV” object 3212, and “dropping” the “ICE” object into the “NON-ALCOHOL BEV” object (e.g., by releasing the hold of the “ICE” object), thereby creating an association between nonalcoholic beverages and ice.", "In some embodiments, the BOD System may be configured or designed to interpret this ICE/NON-ALCOHOL BEV association as indicating that all nonalcoholic beverages are to be served with ice.", "In other embodiments, the BOD System may be configured or designed to interpret this ICE/NON-ALCOHOL BEV association as indicating that patrons are to be automatically offered an option of adding ice to their drink when ordering nonalcoholic beverages via the frontend BOD Service Menu GUI(s).", "For example, in at least one embodiment, similar “drag & drop” functionality may also be provided in one or more frontend BOD Service Menu GUIs displayed to patrons (e.g., via EGM display).", "For example, in one embodiment, when a patron orders a nonalcoholic beverage via the BOD Service Menu interface at an EGM display, the BOD System may automatically respond by displaying a list of condiment items (e.g., ice, lemon, lime, etc.)", "which may be individually selected by the patron and added to the beverage order.", "According to different embodiments, the BOD Service Menu GUIs may be configured or designed to enable patrons to request various types of condiment items to be added to one or more menu items ordered via BOD system.", "Examples of typical complementary condiment may include, but are not limited to: ketchup, mustard, mayonnaise, etc.", "Other types of condiment item requests may be more detailed and/or complex, such as, for example, adding bacon to an order of ice cream, or requesting no ice in your water.", "In at least some embodiments, the condiment functionality of the BOD System may also be utilized for indicating various types of patron preferences which may be associated with one or more ordered items.", "For example, in at least one embodiment, the BOD System may be configured to include a “Hamburger Cooking Preference” condiment group which has been configured to include a plurality of different “condiment items” corresponding to Rare, Medium Rare, Medium, Medium Well, and Well Done.", "When a patron orders a hamburger via the BOD System, the system may identify the “Hamburger Cooking Preference” condiment group, may display the list of “condiment items” (e.g., Rare, Medium Rare, Medium, Medium Well, or Well Done) to the patron, and prompt the patron to indicate how they would like their burger cooked by selecting one of the displayed options.", "In one embodiment, the user's selection (e.g., Medium Rare) may be processed by the system as if it were a condiment item to be added to the hamburger order.", "FIG.", "33 illustrates an example screenshot of a BOD Menu Configuration GUI 3300 which may be configured or designed to enable a user (e.g., casino admin or manager) to configure, add, create, modify, and/or delete various aspects and content relating to: One or more BOD menu primary categories (such as, for example, “Beverages/Drinks”, “Food”, “Merchandise”, “Attendant Services”, and the like).", "One or more BOD menu subcategories (such as, for example, “Beer”, “Liquor”, “Soda”, “Alcoholic Beverages”, “Non-Alcoholic Beverages”, “Appetizers”, “Clothing”, and the like).", "One or more BOD menu items (such as, for example, “Budweiser”, “Coors”, “Basket of French Fries”, “Margarita”, “Baseball Cap”, and the like).", "Etc.", "For example, as illustrated in the example embodiment of FIG.", "33, a BOD Sub-Category Menu may be configured or designed to display a plurality of BOD menu subcategories, including, for example, Beer 3302, Liquor 3304, Soda 3306, Wine 3308.In at least one embodiment, this list of BOD menu subcategories may be associated with a BOD menu primary category such as, for example, “Beverages/Drinks”.", "Features, attributes and/or content associated with an identified BOD category (e.g., Beer 3302) may be modified/re-configured via user interaction with an Edit Icon (e.g., 3303) which may be displayed in association with the identified BOD category.", "Additional subcategories may be added via “Add Primary Category” GUI portion 3061.As illustrated in the example embodiment of FIG.", "33, the BOD Primary Categories Configuration GUI 3300 may also include navigation tabs (e.g., 3011, 3013, 3015) to facilitate the user in navigating to other BOD Menu Configuration GUIs which may be used for configuring and/or modifying BOD menu primary categories, BOD menu items, etc.", "FIG.", "34 illustrates an example screenshot of an alternate embodiment of a BOD Menu Configuration GUI 3400 which, as illustrated in this particular example, may be used for configuring the list and layout of BOD subcategories which are to be included in connection with an identified BOD Sub-Category Menu.", "FIG.", "35 illustrates an example screenshot of an embodiment of a BOD Menu Configuration GUI 3500 which, as illustrated in this particular example, may be used for configuring the list and layout of BOD menu items which are to be included in connection with an identified BOD Item Selection Menu.", "In at least one embodiment, the list of displayed BOD menu items 3510 may be configured or designed to be dynamically sortable by the end user (e.g., on EGM GUI) according to desired sorting criteria such as, for example: Type (Light Beer/Dark Beer) Price Bottle/Tap Popularity and/or other properties associated with the BOD menu items.", "FIG.", "36 illustrates an example screenshot of an embodiment of a BOD Menu Item Configuration GUI 3600 which may be configured or designed to enable a user (e.g., casino admin or manager) to configure, add, create, modify, and/or delete various properties relating to one or more BOD menu item.", "For example, in at least one embodiment, the BOD Menu Item Configuration GUI 3600 may be accessed by a casino administrator or manager for adding a new BOD Menu item to the BOD Menu item catalog/database.", "As illustrated in the example embodiment of FIG.", "36, the BOD Menu Item Configuration GUI may be configured or designed to enable the user to configure, add, create, modify, and/or delete various properties relating to a selected BOD menu item, such as, for example, one or more of the following (or combinations thereof): BOD Menu Item Name 3610 (e.g., in one or more languages).", "BOD Item Ticket Name 3620.In one embodiment, the ticket name may correspond to the name of the BOD Menu Item that may appear on a ticket that prints at the bar.", "For example, the BOD Menu Item Name could be “Bacon Cheeseburger”, while the BOD Item Ticket Name would be “Ben Chzbrgr.” BOD Item Description 3630.In one embodiment, the BOD Item Description may include a short description to describe the Item.", "In some embodiments, the BOD Item Description may include images, drawings, and/or icons representing the Item.", "In some embodiments, the BOD Item Description may be displayed to the patron via the EGM display.", "BOD Item required Condiment Groups 3640.In at least one embodiment, Required Condiment Group(s) may require the patron to provide additional input before the patron is allowed to add the selected Item to their order.", "For example, a BOD Menu Item may have an associated a Required Condiment Group called ‘Drink Flavor’.", "The ‘Drink Flavor’ Condiment Group may include three “Condiments” corresponding to different flavor choices: ‘Cherry’, ‘Grape’, and ‘Lemon/Lime’.", "When the patron adds this BOD Menu Item to their order, the system may automatically prompt the user to choose one of the three condiments flavors to go along with this Item.", "It will be appreciated that these features help simplify the display of the BOD Menu Items by eliminating the need to display three of the same Items at the same price with the only difference being the flavor of the drink.", "During configuration of the BOD Item, in order to add a Required Condiment Group to the Item, a user may click on an “Add New Required Condiment Group” button to cause a dropdown menu to be displayed containing some or all of the BOD Condiment Groups that may be added to this Item as a Required Condiment Group.", "BOD Item available Condiment Groups 3650.In at least one embodiment, Available Condiment Groups may include Condiments that are allowed to be added to the Item.", "During configuration of the BOD Item, in order to add an Available Condiment Group to the Item, a user may click on an “Add New Available Condiment Group” button to cause a dropdown menu to be displayed containing some or all of the BOD Condiment Groups that may be added to this Item as an Available Condiment Group.", "BOD Item limitations/restrictions.", "For example, as illustrated in the example embodiment of FIG.", "36, the BOD Menu Item Configuration GUI 3600 may include a “New Item Limit Tag” GUI portion 3660 which may be configured or designed to enable a user to assign various ordering restrictions and/or limitations relating to this Item.", "In the specific example, the “New Item Limit Tag” GUI portion 3660 includes user configurable fields for imposing limits for Alcoholic and/or Non-Alcoholic Items.", "This means that the patron may only order a certain amount of Alcoholic or Non-Alcoholic Items.", "Once that limit has been reached the patron may no longer be able to add an Item with that type to their order.", "To assign a Limit Tag to the Item, check the radio button next to the Limit Tag name.", "BOD Item pricing 3670.As illustrated in the example embodiment of FIG.", "36, the BOD Item may be configured to have multiple different prices, which may be automatically and dynamically adjusted/updated based on predefined criteria.", "A first price may correspond to a Normal Price Level.", "This is the default price for the Item.", "If no other price point is available for this Item this is the price the system may use.", "One or more additional price points may be added to the Item.", "This may cause the Item have a different price during different Serving Periods.", "In order to add a different price to the Item, a user may click on a new price point button.", "When the user clicks this button a dropdown menu may appear filled with some or all of the Serving Periods that have currently been created.", "Select a Serving Period to continue.", "After a Serving Period has been selected the user may then fill out the price the user want the Item to be during this period.", "The user may also delete one or more existing price points, if desired.", "BOD Item Tax Properties 3680.FIG.", "37 illustrates an example screenshot of an embodiment of a BOD Menu Layout Configuration GUI 3700 which may be configured or designed to enable a user (e.g., casino admin or manager) to configure, add, create, modify, and/or delete various aspects and content relating to the layouts, appearances, features, and/or contents of one or more BOD Menu GUIs.", "For example, as illustrated in the example embodiment of FIG.", "37, a BOD Main Menu GUI may be configured or designed to display a plurality of BOD Menu Primary Categories, Subcategories and/or BOD Menu Items.", "As illustrated in the example embodiment of FIG.", "37, the BOD Menu Layout Configuration GUI may be configured or designed to provide “drag & drop” functionality similar to that described with respect to FIG.", "32.In the specific example embodiment of FIG.", "37, it is assumed that a user is using the GUI's “drag & drop” functionality to select the “Beer” Menu Category 3712 from a list of BOD Menu Primary Categories 3710, and add the selected “Beer” Menu Category as an item of a BOD Main Menu GUI 3720 (e.g., that is intended for presentation via BOD interface of EGM display).", "As illustrated in the example embodiment of FIG.", "37, the BOD Menu Layout Configuration GUI may also include navigation tabs (e.g., 3711, 3713, 3715) to facilitate the user in navigating to other BOD Menu Layout Configuration GUIs which may be used for configuring and/or modifying other BOD Menu GUIs.", "For example, as illustrated in the example embodiment of FIG.", "38, the BOD Menu Layout Configuration GUI 3800 a user may use the GUI's “drag & drop” functionality to select the “LIGHT” Menu Category 3812 from a list of BOD Subcategories (e.g., 3810), and add the selected “LIGHT” Menu Category as an item of a BOD Beer Menu GUI 3820 (e.g., that is intended for presentation via BOD interface of EGM display).", "Similarly, as illustrated in the example embodiment of FIG.", "39, the BOD Menu Layout Configuration GUI 3900, a user may use the GUI's “drag & drop” functionality to select the “BUDWEISER” Menu Item 3922 from a list of BOD Menu Items (e.g., 3910), and add the selected “BUDWEISER” Menu Item as an item of a BOD Beer Menu GUI 3920 (e.g., that is intended for presentation via BOD interface of EGM display).", "In at least one embodiment, the final section of the Menu screen is the EGM preview.", "This is the area where some or all of the Primary Categories, Sub Categories, and Items get “tied together.” One would start by setting up the Main Menu (Primary Categories).", "The user may then continue by adding Sub Categories to the Primary Categories, and finish off by adding Items to the Sub Categories.", "When the user first loads up MM Application, the EGM preview may be blank.", "At that moment, if one were to export the BOD menu to the floor, a patron would not see any items to select from.", "The Main Menu section may only include Primary Categories.", "To start building the EGM menu, one would navigate to the Primary Categories tab.", "This may display a scrollable list of some or all the Primary Categories created.", "The scrollable list appears adjacent to the EGM view.", "In order to add a Primary Category to the EGM preview, simply click and hold on the desired Primary Category and drag it over to the EGM preview.", "Once the user lets go of the mouse the user may drop the Primary Category inside the Main Menu on the EGM preview.", "The user may continue doing so until some or all of the desired Primary Categories are in the Main Menu.", "The Primary Categories that the user sees in the Main Menu of the EGM preview may be the categories that the patron sees when they load up BOD® on the EGM.", "They may appear in the exact order that is displayed on the EGM preview.", "To change the order that the Primary Categories appear in, click and hold on a Primary Category inside the EGM preview.", "As the user moves the Primary Category up and down the user may see the other categories move accordingly.", "Once the user is satisfied with the position of the Primary Category release the mouse to drop it back into the Main Menu.", "If desired, the user may also remove a Primary Category from the Main Menu without removing it completely from the database.", "By doing so, this may remove that Primary Category from the Main Menu and update the position of the others.", "After the Main Menu is set up, it's time to start adding Sub Categories to the Primary Categories.", "The steps to do this are very similar to adding Primary Categories to the Main Menu.", "Configuration of BOD Promotions According to different embodiments, the Content Panel for the Promotion tab may setup the current Promotion which the casino wants to display.", "In at least some embodiments, the Content Panel looks differently in comparison to the Menu view.", "Instead of multiple sections containing scrollable content, the Promotion Content Panel displays a selectable tab (or bar) that displays a promotion name and provides an edit button (similar to the category and item tabs/buttons in the Menu section).", "The Item that is selected for the promotion may be displayed to the player when BOD is loaded to the EGM display.", "When the user loads up the Promotion screen, the user may see the Item that is currently being promoted.", "In order to set the Promotion, navigate to the Promotion Screen and click on the edit icon of the current Promotion.", "This may bring up the Promotion Edit Panel.", "From here the user may select the Item that the user wants to be the new promotion.", "If the user no longer wants any promotion appearing set the current Promotion to ‘None’.", "Configuration of BOD Bar Parameters FIG.", "40 illustrates an example screenshot of an embodiment of a BOD Bar Configuration GUI 4000 which may be configured or designed to enable a user (e.g., casino admin or manager) to configure, add, create, modify, and/or delete various aspects and parameters relating to one or more casino bars, and associated peripherals/resources such as, for example: printers (e.g., receipt printer, order printer), waitstaff, tablets/mobile devices, etc.", "In at least some embodiments, Content Panel for the Bars tab may look similar to the Promotions Content panel (displays a selectable tab (or bar) that displays a name and provides an edit button).", "The Content Panel for the Bars tab may bring up the list of current Bars.", "If there are no bars available, the Content Panel may be empty.", "The bars are where the receipts may be printed when a customer submits their order from the EGM.", "The user may create different bars so that the EGM may print to the bar closest to it.", "In order to add a bar, the user first need to click the “+” Add New Bar button.", "Clicking this button may bring up the New Bar Edit Panel.", "This is where the user may fill out the required information needed to create a new bar.", "FIG.", "41 illustrates an example screenshot of an embodiment of a BOD Bar Edit Panel 4100 which may be configured or designed to enable a user (e.g., casino admin or manager) to configure, add, create, modify, and/or delete various aspects and content relating to one or more casino bars.", "By way of illustration, in one embodiment, there are three sections in the bar Edit Panel: New Bar Name, Set Hours of Operation, and Printer.", "The first section is the New Bar Name.", "The name of the Bar may be something that is easily recognizable to what Bar in the casino it belongs to.", "In the example Bar shown, the Bar is named “South Bar”.", "This indicates that the Bar to be printed to is located on the south side of the casino.", "The next section to fill out is Set Hours of Operation.", "In this section the user may define the open and close time of the Bar.", "These boxes are based on a 24 hour clock (4 am=4:00, 4 pm=16:00).", "The first three boxes indicate the open time.", "The first box is for hour and the second is for minutes.", "The third box is for seconds but that is defaulted to 0.The last three boxes indicate the close time for the Bar.", "The first box is for hours and the second box is for minutes.", "The third box is for seconds but that is defaulted to 59.If the bar never closes, the user may set the open time to 00:00:00 and the close time to 23:59:59.The final section to fill out is the Printer section.", "This is where the user defines the printer that the Bar may print at.", "There are two dropdown menus in this section.", "The first menu is for what printer the Bar uses when it's open.", "When the user opens this menu the user may see a list of printers that are accessible to the server.", "Choose the printer that this Bar uses.", "The second dropdown menu is for the printer the Bar may use if it's closed.", "For example: if all Bars in the casino closes except for one, the user may select the printer of the Bar that is still open in this menu.", "This may allow the EGMs that are tied to a closed bar to still be able to use BOD® on the EGM.", "If the user wants the EGMs that are tied to this bar to close down with the bar, select ‘None’ as the printer for the closed hours.", "This may cause a message saying that the bar is closed to appear on the EGM.", "This message is customizable from the Configure Screen (discussed later).", "If the dropdown menu for the printers is empty or not up to date, the user may need to click the “Update Printer List” button.", "It may take a second for the printer list to load.", "Once it does the user may select a printer from the dropdown list.", "In at least one embodiment, the BOD System supports network POS printers.", "A ‘Test Printer’ button is available to make sure that BOD may print to the selected printers.", "Pressing this button may print out a small test page on the printers selected in the dropdown menus.", "NOTES: The BOD service may be running in order to use the “Update Printer List” button.", "Also, the server may have access to the printer on the network in order to print to it.", "Also, the BOD service may be running to use the “Test Printer” button.", "When the user is finished filling out the sections, click on the save icon to create the Bar.", "In order to edit a Bar, click on the edit icon.", "Clicking this icon may bring up the Bar Edit Panel.", "From here the user may change any of the information that was set when creating the Bar.", "In order to delete a bar, click on the “Delete Bar” button.", "Configuration of BOD Serving Period Parameters FIG.", "42 illustrates an example screenshot of an embodiment of a BOD Serving Period Configuration GUI 4200 which may be configured or designed to enable a user (e.g., casino admin or manager) to configure, add, create, modify, and/or delete various aspects and parameters relating to various BOD Item serving periods.", "In at least one embodiment, a Serving Period describes the time of day when certain items appear and at what price.", "According to different embodiments, aspects relating to Item pricing and availability may be configured or designed to dynamically vary depending on different conditions/criteria such as, for example, one or more of the following (or combinations thereof): Time of Day; Patron/Customer ID (e.g., high rollers may be allowed to order breakfast 24/7); Availability; Relative level of traffic/customers at bar/restaurant location (real-time); Relative real-time demand of services/orders (e.g., prices may increase if the number of orders currently in queue exceeds some predefined threshold); Etc.", "In some embodiments, the Content Panel of the Serving Period screen may show some or all of the Serving Periods that have currently been created.", "In one embodiment, all times under a Serving Period are define in a 24 hour format (e.g.", "4 pm=16:00).", "Serving Periods are directly related to pricing levels.", "When a Serving Period is created a new price level may appear in the dropdown menu when creating/editing an item.", "In order to create a Serving Period the user may first click on the “+” Add New Serving Period button.", "Clicking on this button may display the Serving Period Edit Panel.", "This is where the user may fill in the required information needed to create a new serving period.", "In one embodiment, the Serving Period Edit Panel has two sections.", "The first section is New Serving Period Name.", "The name of the Serving Period may be something that is easily recognizable to what time the serving period represents.", "Examples of serving period names would be: Breakfast, Lunch, Happy Hour, or Dinner.", "The next section to fill out is the New Serving Period Time.", "In this section the user may define the time of the serving period.", "The input boxes are based on a 24 hour clock (e.g.", "4 am=4:00, 4 pm=16:00).", "The first three boxes indicate the start time.", "The first box is for hours, the second box is for minutes, and the third box is for seconds (which is default to 0).", "The last three boxes indicate the end time of the serving period.", "The first box is for hours, the second box is for minutes, and the third box is for seconds (which is default to 59).", "It's important to note that serving periods cannot overlap.", "If a serving period falls in the middle of another they may be separate.", "For example: Let's say Dinner starts at 3 pm (15:00) and ends at lam (01:00).", "However, in the middle of dinner there is a Happy Hour that lasts from 4 pm (16:00) to 6 pm (18:00).", "In order to accomplish this, the user may break up dinner into 2 different serving periods.", "The end result would look like this: Dinner (Part 1): 15:00:00-15:59:59, Happy Hour: 16:00:00-17:59:59, Dinner (Part 2): 18:00:00-00:59:59.When the user is finished filling out the sections, click on the save icon to create the Serving Period.", "In order to edit a Serving Period, click on the edit icon.", "Clicking this icon may display the Serving Period Edit Panel.", "From here the user may change any of the information that was set when creating the Serving Period.", "In order to delete a serving period, click on the “Delete Serving Period” button.", "Configuration of BOD Waitstaff Parameters FIG.", "43 illustrates an example screenshot of an embodiment of a BOD Waitstaff Configuration GUI 4300 which may be configured or designed to enable a user (e.g., casino admin or manager) to configure, add, create, modify, and/or delete various aspects and parameters relating to one or more Waitstaff.", "In at least one embodiment, the Content Panel for Waitstaff displays the pin that is currently being used to close out orders.", "When a player has submitted an order, they may see a pin pad displayed on the EGM (whenever they open/re-open BOD).", "To close out an order as “delivered” the waitress/waiter may put in the pin number.", "The user may change the pin number used to close out orders by clicking on the edit icon.", "Clicking on this icon may display the Waitstaff Edit Panel.", "From here, the user may set the pin to be any 4-8 digit number.", "When the user is finished setting up the pin, click the save icon to save any changes.", "Configuration of BOD EGM Parameters FIG.", "44 illustrates an example screenshot of an embodiment of a BOD EGM Configuration GUI 4400 which may be configured or designed to enable a user (e.g., casino admin or manager) to configure, add, create, modify, and/or delete various aspects and parameters relating to one or more EGMs.", "In at least one embodiment, the Content Panel for the EGM's may display a list of some or all the EGM locations currently created.", "The EGM location comprises of the zone and bank of the EGM.", "The user may use these created EGM locations to assign the EGM's on the floor to a bar.", "In order to create an EGM location the user first clicks on the “+” Add EGM Location button.", "Clicking on this button may display the EGM location Edit Panel.", "This is where the user may fill in the required information needed to create a new EGM location.", "From here the user may need to fill out three sections: New EGM Zone, New EGM Bank, and Associated Bar.", "The first section is the New EGM Zone.", "The user may need to put in the zone that the EGM is located at.", "The second section is the New EGM Bank.", "The user may need to put in the EGM's bank number here.", "The third section is the Associated Bar.", "This may display a list of some or all the bars that have been created.", "Selecting a bar from the list may assign this EGM to that bar.", "Each order that is placed on this EGM may print based on that bar's information.", "In order to edit an EGM location, click on the edit icon.", "Clicking this icon may display the EGM Location Edit Panel.", "From here the user may change any of the information that was setup when creating the EGM locations.", "In order to delete an EGM location, click on the “Delete EGM Location” button.", "Configuration of BOD Ad Parameters FIG.", "45 illustrates an example screenshot of an embodiment of a BOD Ad Configuration GUI 4500 which may be configured or designed to enable a user (e.g., casino admin or manager) to configure, add, create, modify, and/or delete various aspects and parameters relating to one or more ads to be presented via the BOD System.", "In at least one embodiment, the Content Panel for Ads may display some or all of the items that are set to be inside the Ad section of the skin (i.e., graphical interface displayed on the EGM).", "The Ad section of the skin may rotate between these items.", "This may allow a patron to have quick access to some or all of these items.", "In order to add an Ad to the rotation, click the “+” Add Ad button.", "Clicking this button may display the Add New Ad Edit Panel.", "From here the user may have a dropdown menu listing some or all the items that have currently been created.", "Select the item the user wants to add from the menu.", "Once the user has selected your item, click save to add it to the rotation.", "In order to remove an Ad from the rotation, click on the “Delete from Ad” button.", "Configuration of BOD Item Tax Parameters In at least one embodiment, the Content Panel of Tax may display the current tax percentage.", "This percent may be applied to some or all items in the patrons order.", "In order to set the current tax, click on the edit icon.", "Clicking this button may display the Tax Edit Panel.", "From here the user may set the current tax percentage.", "When the user is finished filling out the tax percentage, click the save icon.", "Configuration of BOD Item Limits/Restrictions Parameters FIG.", "46 illustrates an example screenshot of an embodiment of a BOD Limits Configuration GUI 4600 which may be configured or designed to enable a user (e.g., casino admin or manager) to configure, add, create, modify, and/or delete various aspects and parameters relating to one or more limits and/or restrictions (herein “Limits”) which may be assigned to various BOD Menu items.", "According to different embodiments, different Limits may be defined/configured based on specifically defined conditions/criteria such as, for example, one or more of the following (or combinations thereof): Per order Per person Per EGM Per menu item Per time period And/or other criteria By way of illustration, in some embodiments, the Content Panel for Limits may display some or all of the Limit Tags that have been created, as well as their amounts.", "Limit Tags are something the user may attach to an Item.", "At least one Limit Tag may have an amount associated with it.", "The amount associated with the Limit Tag may determine how many of those Items the player may add to their order.", "For example: We may create a Limit Tag called ‘Alcoholic’ and set it's amount to 2.This means that the player may only add 2 Items with the ‘Alcoholic’ Limit Tag.", "These Items could be the same ones or different ones, but either way only 2 Items with this tag may be added to the order.", "When the player has reached the limit for those Items, the “add to order button” for any Item with that tag may be grayed out.", "In order to create a limit tag, click on the “+” Add Limit Tag button.", "Clicking on this button may display the New Limit Tag Edit Panel.", "This is where the user may fill in the required information needed for creating a new Limit Tag.", "There are two sections to fill out: New Limit Name and New Limit Amount.", "The first section is New Limit Name.", "This is where the user may assign the Limit Tag a name.", "The name may be something easily recognizable to the items it may be attached to.", "NOTE: An item may only have ONE Limit Tag attached to it.", "The second section is New Limit Amount.", "This is where the user assigns the amount of items with this Limit Tag the player may be allowed to add to their order.", "In order to edit a Limit Tag, click on the edit icon.", "Clicking on this icon may display the Limit Tag Edit Panel.", "From here the user may change any of the information that was set when creating the Limit Tag.", "When the user is finished filling out the Limit Tag information, click the save icon to save any changes.", "In order to delete a Limit Tag, click on the “Delete Limit Tag” button.", "Configuration of Other BOD Parameters FIG.", "47 illustrates an example screenshot of an embodiment of a BOD Parameter Configuration GUI 4700 which may be configured or designed to enable a user (e.g., casino admin or manager) to configure, add, create, modify, and/or delete various aspects and parameters associated with the BOD System.", "In at least one embodiment, the Content Panel for the BOD Parameter Configuration GUI (herein “Configure”) may display various sections dedicated to configuring the basic information for the BOD System.", "The Database Information section is where the user may change how to access the database.", "In order to access this information, click on the edit icon.", "Clicking on this icon may display the Database Information Edit Panel.", "The Database Information section contains four parts: Change username, Change Password, Change Database, and Change Server.", "The first section is Change Username.", "This is where the user may put the username needed to access the database.", "The second section is Change Password.", "This is where the user may change the password to access the database.", "Enter the old password that was used in the first field, and then enter the new password the user want into the second field.", "The last field is to verify the new password.", "The third section is Change Database.", "This is where the user may change the database the Menu Manager may use to display the Menu information.", "The final section is Change Server.", "In this section the user may set the server that the BOD® database is located on.", "When the user is finished filling out the Database Information, click the save icon to save any changes.", "The Language section is where the user may set what languages are available for the player to access inside the Beverage On Demand® skin on the Service Window.", "This section may determine some or all of the input boxes for Name and Description that appear when creating a Primary Category, Sub Category, or Item.", "This is where the user may fill out the required information for creating a new Language.", "The Language Edit Panel comprises of four sections: New Language Name, Language Abbreviation, Default Language, and Supported Language.", "The first section is New Language Name.", "This is where the user may fill out the name of the language.", "This is the name that may display on the EGM when the player presses the Language button.", "The second section is Language Abbreviation.", "This is a short abbreviation for the language.", "The next section is Default Language.", "The user may check this box if the user want to use this language as the default language.", "Setting a language as default may make the BOD® skin (displayed on the EGM) load up that language.", "The final section is Supported Languages.", "Checking this box may cause this language to appear when the player selects a language from the BOD® skin on the EGM.", "When the user is finished filling out the section for New Language, click the save icon to create the language.", "In order to edit a language, click on the edit icon.", "Clicking on this button may display the Language Edit Panel.", "From here the user may change any of the information that was set when creating the language.", "Use the dropdown menu under “Choose Language” to change the language the user want to edit.", "When the user is finished filling out the language information, click on the save icon the save your changes.", "In order to delete a language, click on the “Delete Language” button.", "After the user has created languages, the user may configure which language is default and which languages are supported by clicking the edit icon.", "Clicking this icon may display the Language Edit Panel.", "This dialog has two sections, Default Language and Supported Languages.", "The first section is Default Language.", "This section displays a dropdown menu of the languages that have been created.", "The user may select a different default language here.", "The second section is Supported Languages.", "This section may allow the user to add and remove supported languages.", "When the user is finished changing the language information, click the save icon to save any changes.", "The EGM Translation section is where the user may change some or all of the phrases that appear on the BOD® skin.", "Selecting the edit icon may display the EGM Translation Edit Panel.", "The EGM Translation Edit Panel comprises of two sections: Language to translate and Phrases.", "The first section is Language to Translate.", "This section contains a dropdown menu filled with the languages that have been created.", "Here the user may select what languages the user wants to start translating.", "The second section is Phrases.", "Here is a list of phrases with their description above them.", "The user may edit these phrases to fit the language the user is translating.", "When the user is finished translating the phrases, click the save icon to save any changes.", "The Currency section may allow the user to setup how the currency is formatted.", "Clicking on the edit icon may display the Currency Edit Panel.", "The Currency Edit Panel comprises of three sections: Currency Symbol, Currency Delimiter, and Currency Decimal.", "The first section is Currency Symbol.", "Here the user may change the symbol to use in front of any price.", "The second section is Currency Delimiter.", "Here is where the user may setup the character that appears when a price enters the thousands (e.g.", "1,000 the“,” character is the delimiter).", "The last section is Currency Decimal.", "Here the user may be able to set the character that may appear before the cents in a price (e.g.", "3.99 the “.” Character is the decimal).", "When the user is finished setting the Currency information, click the save icon to save any changes.", "The Item Limit Per Order section may allow the user to set how many items the player is allowed to place in one order.", "This is not to be confused with Limit Tags.", "Limit Tags only apply to items with the same tag whereas Item Limit Per Order is applied to all (or selected) items in the menu.", "In one embodiment, the Item Limit Per Order may override any Limit Tags that are set.", "Example: if the user set the Limit Tag of “Alcoholic” to be 5 and the Item Limit Per Order to be 2, the player may only be able to order 2 items total.", "Clicking on the edit icon may display the Item Limit Per Order Edit Panel.", "This Edit Panel only has one section: Limit of Items per Order.", "In this section the user may define how many items the player is allowed to add to their order.", "When the user is finished setting the Item Limit, click the save icon to save any changes.", "The Time Limit Between Orders section allows the user to set up how much time may pass before the player may place another order.", "Clicking on the edit icon may display the Time Limit Between Orders Edit Panel.", "This dialog only has one section: Time Limit Between Orders.", "The user may set how long (in minutes) the player may wait before placing another order.", "When the user is finished setting the time limit, click the save icon to save any changes.", "The Order Time Out section allows the user to set how long to wait before a player pulls their card from the machine before automatically cancelling the order.", "When a player pulls their card out of the machine a message informing the staff may print at the bar associated with that machine.", "The player then has a certain amount of time to put their card into another (or same) machine before their order is automatically cancelled.", "This is where the user may define that time.", "In some embodiments, if the player inserts their card into another machine before the time limit expires, a message informing the staff may print out at the bar associated with the original machine.", "Clicking on the edit icon may display the Order Time Out Edit Panel.", "This dialog has one section: Time After Card out.", "In this section the user may put the amount of time (in minutes) that may pass, after the player has pulled their card, before the order is automatically cancelled.", "When the user is finished setting up the time out limit, click the save icon to save any changes.", "The Comments section is where the user may define if the player is allowed to add comments to their order.", "If this is enabled when a player is viewing their order, they may see an “Add Comments” button.", "Clicking this button may bring up a keyboard where they may type additional information to the staff members.", "Comments could allow the player to inform the staff to “Bring 2 straws” or “Extra napkins.” Clicking on the edit icon may display the Comments Edit Panel.", "This dialog has only one section: player Comments.", "This section may let the user enable or disable player comments.", "When the user is finished setting the comments, click the save icon to save any changes.", "The Receipt section may allow the user to customize the look of the receipt that prints out at the bar.", "Clicking on the edit icon may display the Receipt Edit Panel.", "FIG.", "48 illustrates an example screenshot of an embodiment of a BOD Receipt Configuration GUI 4700 (referred to as “Receipt Edit Panel”) which may be configured or designed to enable a user (e.g., casino admin or manager) to configure, add, create, modify, and/or delete various aspects and parameters associated with the BOD transactions and receipts.", "In at least one embodiment, the Receipt Edit Panel may include seven sections: Header Line 1, Header Line 2, Header Line 3, Patron Information Options, EGM Information Options, Footer Line 1, and Footer Line 2.The first three sections have to do with the header of the Receipt.", "For Header Line 1, Header Line 2, and Header Line 3 the user may fill out any information that the user would like displayed at the top of the Receipt.", "The forth section is Patron Information Options.", "In this section the user may turn on/off some or all portions of the information about the patron that the user want to appear on the Receipt.", "The fifth section is EGM Information Options.", "This is where the user may turn on/off some or all portions of the information about the EGM that the user want to appear on the Receipt.", "The last two sections have to do with the footer of the Receipt.", "For Footer Line 1 and Footer Line 2 the user may fill out any information that the user would like displayed at the bottom of the Receipt.", "When the user is finished filling out the information about the Receipt, click the save icon to save any changes.", "An example of the Receipt that may be printed at the Bar is illustrated in FIG.", "49.In at least one embodiment, The Receipt Translation may allow the user to translate any of the phrases that appear on the Receipt (ex: Player Name, Machine Number).", "Click on the edit icon to open the Receipt Translation pop up dialog.", "The Receipt Translation pop up dialog has one section: Phrases.", "Here is where the user may change the translation of the phrases that appear on the Receipt.", "When the user is finished translating the phrases for the Receipt, click the save icon to save any changes.", "FIG.", "49 shows an example embodiment of “BOD Order Ticket” which may be automatically displayed or printed out at a designated BOD fulfillment station (e.g., specifically selected bar/restaurant) in connection with a BOD order submitted by a specific patron at a specific EGM.", "In at least one embodiment, the BOD Order Ticket may also serve as the customer's (e.g., patron's) receipt.", "According to different embodiments, the BOD Order Ticket (or other type of ODS Order Ticket) may include various information such as, for example, one or more of the following (or combinations thereof): Information relating to the identity and location of the casino.", "Information 4902 relating to the order date, time, day, order number, etc.", "Information 4904 relating to the player/patron identity, player/patron location, EGM ID, EGM location (e.g., bank, zone), etc.", "Information 4906 identifying each ordered item and associated condiments to be included with each ordered item, price of each ordered item, etc.", "Pricing Information 4908 relating to subtotal amount(s), food total amount(s), bar total amount(s), tax amount(s), order total amount, etc.", "Payment information relating to payments, coupons, comps, and/or discounts applied to the order.", "Comment information 4910 which may include notes or comments provided by the patron to be taken into consideration when processing the order.", "And/or other types of information described and/or referenced herein.", "BOD Reporting Functionality FIGS.", "50-54 illustrate example screenshot embodiments of various BOD Report GUIs which may be configured or designed to enable a user (e.g., casino admin or manager) to generate various types of reports relating to selected aspects of the BOD System.", "In some embodiments, the BOD Report GUIs also may be configured or designed to enable a user (e.g., casino admin or manager) to access, monitor, track, and/or manage real-time status information relating to the BOD orders, inventory, personnel, etc.", "By way of illustration, in one embodiment, the Content panel for the Reports Screen (FIG.", "50) may allow the user to view some or all of the transactions that have occurred using the Beverage On Demand® System.", "Here the user may be able to view some or all the orders that have been placed, as well as view the receipt and generate reports.", "The Reports Screen comprises of three tabs: Order Tracking, Delete Orders, and Generate Reports.", "Clicking on the Order Tracking tab 5003 may give the user a list of some or all of the orders that have been placed on the selected day.", "The right section of the screen may show the full order for the one selected on the left.", "The user may select a different day to view from the ‘Select Date’ dropdown menu.", "Clicking on the Delete Orders tab 5005 may allow the user to remove old transactions from the system's database.", "To delete old transactions select the date that the user would like to delete up to and click the ‘Delete Transactions’ button.", "When selecting a date keep in mind that it may delete some or all of the transactions that have taken place on AND before the selected date.", "The Generate Reports tab 5007 may allow the user to generate reports based on different criteria.", "When the user first loads up the Reports tab the user may need to select which type of report the user want, the start date and end date, and then press the ‘Apply Filter’ button.", "NOTE: If the user leaves the start and end date alone the user may get all of the orders regardless of the date.", "There are a total of four different reports to choose from: Location, Date, Items, and Player.", "The Location report (e.g., FIG.", "51) may group some or all of the transactions by the location the transaction came from.", "In this report the user may see the location the transactions came from, the number of sales that took place in that location, the total amount the sales add up to, and the average price of at least one.", "The Date report (e.g., FIG.", "52) may group some or all of the transactions by the date they took place.", "In this report the user may see the date the transactions took place, the number of orders that occurred on that date, the total amount the sales add up to, and the average price per sale.", "The Items report (e.g., FIG.", "53) may group the transactions by the items that have been ordered.", "Here the user may see how many of at least one item has been sold, the name of the item, and the total amount of sales made from that item.", "The Player report (e.g., FIG.", "54) may group the transactions by player.", "In this report the user may see the player's ID, the player's name, the number of orders they have placed, the total amount of sales from that player, and the average price of at least one sale.", "After the user has chosen a report (and a filter if wanted), the user is given the option to save the report.", "In order to save the report click the ‘Save Report’ button at the bottom of the Reports tab.", "This may create a CSV file on the BOD™ server.", "The user may choose to save this file anywhere, however, backup report files are automatically saved on the BOD™ server.", "The Content Panel for the Export Screen may export the database for use on the EGM.", "Any changes saved to the database may not appear on the EGM until the database has been exported.", "If there are any problems with items missing on the EGM this is the first thing that may be checked.", "The Export Screen may have one row with the name “EXPORT”.", "In order to export the database for use on the EGM click on the edit icon.", "Clicking on this icon may bring up the Export pop up dialog.", "To confirm export to the database, click on the edit icon inside the pop up dialog.", "If the BOD™ service is running, the new menu may appear on the EGM instantly.", "Otherwise the menu may be updated the next time the BOD™ service is started.", "According to different embodiments, the On Demand Services System may be configured or designed to provide alternative and/or additional BOD-related features and functionality such as, for example, one or more of the following (or combinations thereof): 30 day trial with serial activation Closed loop system Patron ability to cancel their order Robust user interface (smartphone inspired) Robust back-end interface (drag and drop functionality) Limit the amount of total items a patron may order at once Limit the amount of alcoholic items a patron may order at once Limit the amount of orders a patron may order during a given time period Enable/disable patron's ability to add comments to their order Configure the order of Categories/Items via the backend system (drag and drop) Configurable pop-up ad before BOD starts Configurable ad banner on the BOD patron skin (EGM patron interface) Configurable receipt information (first name, last name, tier, is birthday) Custom item images may be uploaded (through IGT's Media Manager) Card In/Card Out detection (tells waitstaff if patron has left EGM and what new EGM they're at) Patron notifies of form of payment Micros integration Infogenesis integration Configurable pop-ups (based on age/gender/time/location/birthday/etc.)", "Patron favorites (displays top 3 based on starred and/or most ordered) Configurable drink pop-up for one-time redemption (patron's birthday etc.)", "Allow free drinks for different patron tiers Analytics (tracks how often patron's look at Categories/Items, how often they select said items, and how long they look at promotional ads) Heat Map generation (shows hot and cold areas of the gaming floor to maximize wager potentials) Ability to apply X % discount based on gender/age/tier/time/location/etc.", "Mobile app (for waitstaff closed loop and ordering) Limit and/or ban specific patrons (responsible gaming/person systems) BYOD Set up (Bring Your Own Device) may allow for players to utilize their own devices by logging into a secure local/in-house system Host on Demand (HOD) Services Features and Management In at least one embodiment, “Host On Demand®” allows a patron to contact a host and/or a VIP host via an EGM interface.", "A more personalized method than pressing the attendant button.", "Patron machine location/information is sent to a host, VIP host and/or concierge via a “plurality” of configurable means setup within the ODS Menu Manager Application.", "In at least some embodiments, different features of the HOD Services may be offered or provided for different hosts/services offered by the casino, such as, for example, concierges, bellhops, VIP services, business-related services, etc.", "FIG.", "13 shows an example screenshot of a HOD Menu GUI 1300, in accordance with one embodiment.", "The example HOD Menu GUI illustrated in FIG.", "13 is configured as a frontend GUI which may be displayed and/or accessed by patrons via one or more EGM interfaces.", "FIGS.", "19-21 illustrate example screenshot embodiments of various Host On Demand (HOD) Manager GUIs which may be configured or designed to enable a user (e.g., casino admin or manager) to access, manage, configure and/or modify various aspects, features, and parameters relating to the HOD Service(s).", "In some embodiments, one or more HOD Manager GUIs also may be configured or designed to enable a user (e.g., casino admin or manager) to access, monitor, track, and/or manage real-time status information relating to various aspects of the HOD Service.", "In one embodiment, the HOD Manager is where the user may setup the information needed to send alerts.", "Here, the user may enter the email address from which the user may send alerts as well as indicate whether the user wish to receive the alerts via email, a short message service (SMS), or a printer.", "In order to access the Manager, navigate to the server on which it is installed.", "From here, open Internet Explorer®.", "By default, the homepage may be set to the Synergy Blue AppSite page.", "If for some reason the home page has changed, the AppSite page may be found at: localhost/appsite.", "Once the user has loaded up the AppSite, the user may need to click on the Host On Demand® button.", "In at least one embodiment, the Manager interface comprises of two sections: Tab Bar and Info Panel.", "The Tab Bar is where the user may navigate between the different tabs of the HOD® Manager.", "The three tabs are: General Setup 1902, Host Setup 1904, and Reports 1906.The Info Panel provides some or all the information for the selected tab.", "Use the Info Panel to view and edit the information needed for at least one tab.", "The General Setup tab (e.g., FIG.", "19) is where the user may input some or all the information for the sender's email.", "This is the email that the alerts may come from.", "The HOD service may be running in order to access the General Setup tab.", "After loading up the HOD Manager site, the General Setup tab may automatically be selected.", "The user may now begin filling out the General Setup fields.", "The first field to fill out is the port number.", "This is the port that is used to send emails.", "The default port is 587.This may not need to be changed.", "The second field to fill out is the actual email address of the sender.", "Example: myusername@email.com.", "The third field to fill out is the SMTP server address.", "This may be the address of the SMTP server the email address from the second filed uses to send emails.", "Example: smtp.email.com.", "The fourth field to fill out is the username for the email account.", "This is the username needed to log into the email address provided in field two.", "The fifth and sixth field needed to fill out is the password for the email account.", "This is the password needed to log into the email address provided in field two.", "The fifth and sixth field may match in order to submit changes.", "The last thing needed to fill out is a dropdown box.", "This may be the default language HOD may use when loaded onto the EGM.", "After the user has filled out some or all of the fields press the “Save” button to save the changes.", "The HOD service may be running in order to access the Host Setup tab (e.g., FIG.", "20).", "The Host Setup tab is where the user may choose how the user wants to receive alerts.", "The HOD™ system is able to send alerts in three different ways: to an email address, to a cell phone using a short message service (SMS), or to a printer.", "After loading the HOD Manager site, click the Host Setup tab.", "This may load some or all of the information needed in the Info Panel.", "From here, the user may select how the user would like to receive alerts.", "The user may choose at least one; however, if desired, the user may select some or all three options.", "If the user chooses all three, the user may receive an email, an SMS text, and a printed ticket when a customer uses the when someone uses HOD™ option.", "Checking the Email check box may activate the email field.", "In this field, type the email address that is to receive the alerts.", "Selecting the SMS check box activates three fields: the phone number field, the service provider drop-down menu, and the add a provider field.", "In the phone field enter the phone number to which the SMS texts may be sent.", "In the service provider dropdown menu, select the appropriate service provider.", "To remove a service provider from the list, select that provider in the dropdown list and click the Remove Provider button.", "The final field may allow the user to add a provider to the dropdown list.", "The user may need to check with your service provider to find out the correct SMS gateway to use.", "Make sure the user include everything needed in the SMS gateway that follows the “@” symbol, including the “@” symbol itself at the beginning (e.g.", "@txt.att.net).", "After entering the SMS gateway into the provider field, click the Add Provider button to add the provider to the dropdown menu.", "Selecting the printer check box may activate the printer dropdown menu.", "From here, select the printer that is to print your alerts.", "If printer selections do not appear, or the list is out of date, click the Update Printer List button to access the list of printers.", "After setting up how the user would like to receive alerts, press the Save button to save any changes.", "The Reports tab (e.g., FIG.", "21) is where the user may be able to access or view (e.g., in real-time) some or all of the calls made by the HOD system.", "In one embodiment, there are four different types of reports to view: Bank, Calls, Machine Number, and Player.", "The Bank Report lists how many calls at least one Bank ID has made.", "The Calls Report lists some or all of the individual calls made.", "The Machine Number Report lists how many calls at least one machine has made.", "The Player Report lists how many calls at least one player made.", "After loading the HOD® Manager site, click the Reports tab.", "From the dropdown menu, select the type of calls on which to report.", "From the second dropdown menu, select the appropriate type of report.", "The system displays the requested call data.", "The user may filter the reports by selecting a start date and by clicking the Filter Report button.", "The system lists some or all of the calls that have occurred during that time period.", "The user may return to the non-filtered view by clicking the Reset Filter button.", "The user may save a report by clicking the Save Report button.", "This creates a report from the information that is currently being displayed.", "After the report is created, the system displays a Save window, which may allow the user to save the file locally.", "Security on Demand (SOD) Enhanced Services Features and Management In at least one embodiment, “Security On Demand®” (SOD) Service allows a patron to contact a security official and/or a medical aid representative.", "Patron machine location/information is sent to security and/or medical advisor via a “plurality” of configurable means setup within the ODS Menu Manager Application.", "FIG.", "14 shows an example screenshot of a SOD Menu GUI 1400, in accordance with one embodiment.", "The example SOD Menu GUI illustrated in FIG.", "14 is configured as a frontend GUI which may be displayed and/or accessed by patrons via one or more EGM interfaces.", "FIGS.", "22-25 illustrate example screenshot embodiments of various Security On Demand (SOD) Manager GUIs which may be configured or designed to enable a user (e.g., casino admin or manager) to access, manage, configure and/or modify various aspects, features, and parameters relating to the SOD Service(s).", "In some embodiments, one or more SOD Manager GUIs also may be configured or designed to enable a user (e.g., casino admin or manager) to access, monitor, track, and/or manage real-time status information relating to various aspects of the SOD Service.", "In at least one embodiment, the Security On Demand™ Manager is where the user may setup the information needed to send security and medical alerts.", "Here the user may enter what email to send alerts from, as well as whether to receive the alerts through email, SMS, or printer.", "In order to access the Manager, navigate to the server that it was installed on.", "From here, the user may need to open up Internet Explorer.", "By default the homepage may be set to the Synergy Blue Apps page.", "Once the user has loaded up the app site the user may need to click on the ‘Security On Demand™’ button.", "This may take the user to the Manager interface.", "The Menu Manager interface comprises of two sections: Tab Bar, and Info Panel.", "The Tab Bar is where the user may navigate between the different tabs of the Security On Demand™ Manager.", "The four tabs are: General Setup, Security Setup, Medical Setup, and Reports.", "The Info Panel provides some or all the information for the selected tab.", "The info panel may be used to view and edit the information needed for at least one tab.", "The General Setup tab (e.g., FIG.", "22) is where the user may input some or all the information for the sender's email.", "This is the email that the security/medical alerts may come from.", "The SOD service may be running in order to access the General Setup tab.", "After loading up the Security On Demand™ Manager site the General Setup tab may automatically be selected.", "The user may now begin filling out the General Setup fields.", "The first field to fill out is the port number.", "This is the port that is used to send emails.", "The default port is 587.This may not need to be changed.", "The second field to fill out is the actual email address of the sender.", "Example: myusername@email.com.", "The third field to fill out is the SMTP server address.", "This may be the address of the SMTP server the email address from the second field uses to send emails.", "Example: smtp.email.com.", "The fourth field to fill out is the username for the email account.", "This is the username needed to log into the email address provided in field two.", "The fifth and sixth field needed to fill out is the password for the email account.", "This is the password needed to log into the email address provided in field two.", "The fifth and sixth field may match in order to submit changes.", "The last thing needed to fill out is a dropdown box.", "This may be the default language Security On Demand™ may use when loaded onto the EGM.", "After the user has filled out some or all of the fields press the ‘Save’ button to save the changes.", "The Security Setup tab (e.g., FIG.", "23) is where the user may choose how the user wants to receive security alerts.", "The Security On Demand™ system is able to send alerts in three different ways: Email, SMS Message, and Printer.", "The SOD service may be running in order to access the Security Setup tab.", "After loading up the Security On Demand™ Manager site, click on the Security Setup tab.", "This may load some or all of the information needed in the Info Panel.", "From here the user may select how the user would like to receive security alerts.", "The user may choose at least one, however, the user may have some or all three selected if the user want.", "If the user chooses some or all three when someone uses Security On Demand™ the user may get an email, SMS Message, and printed ticket.", "Checking the Email checkbox may bring up the email field.", "In this field the user may put the address of the email that the user would like to use to receive security alerts.", "Checking the SMS checkbox may bring up three fields: the phone number field, the service provider dropdown box, and add a provider field.", "In the phone number field the user may put the phone number where the user would like to receive security alerts via SMS messages.", "In the service provider dropdown box, find the service provider for the number provided in the phone number field.", "To remove a service provider from the list select that provider in the dropdown list and click the ‘Remove Provider’ button.", "The final field may allow the user to add a provider to the dropdown list.", "Make sure the user include everything needed in the Mail to SMS gateway that follows the ‘@’ symbol, including the ‘@’ symbol itself at the beginning (example: @txt.att.net).", "Checking the Printer checkbox may bring up the printer dropdown box.", "Here the user may select a printer that the user would like security alerts to print to.", "If no printers appear, or the list is out of date, click the ‘Update Printer List’ button to get the list of printers.", "After setting up how the user would like to receive security alerts, the user may press the ‘Save’ button to save any changes.", "The Medical Setup tab (e.g., FIG.", "24) is where the user may choose how the user wants to receive medical alerts.", "The Security On Demand™ system is able to send alerts in three different ways: Email, SMS Message, and Printer.", "The SOD service may be running in order to access the Medical Setup tab.", "After loading up the Security On Demand™ Manager site, click on the Medical Setup tab.", "This may load some or all of the information needed in the Info Panel.", "From here the user may select how the user would like to receive medical alerts.", "The user may choose at least one, however, the user may have some or all three selected if the user want.", "If the user chooses some or all three when someone uses Security On Demand™ the user may get an email, SMS Message, and printed ticket.", "Checking the Email checkbox may bring up the email field.", "In this field the user may put the address of the email that the user would like to use to receive medical alerts.", "Checking the SMS checkbox may bring up two fields: the phone number field, and the service provider dropdown box.", "In the phone number field the user may put the phone number where the user would like to receive medical alerts via SMS messages.", "In the service provider dropdown box, find the service provider for the number provided in the phone number field.", "To remove a service provider from the list select that provider in the dropdown list and click the ‘Remove Provider’ button.", "The final field may allow the user to add a provider to the dropdown list.", "Make sure the user include everything needed in the Mail to SMS gateway that follows the ‘@’ symbol, including the ‘@’ symbol itself at the beginning (example: @txt.att.net).", "Checking the Printer checkbox may bring up the printer dropdown box.", "Here the user may select a printer that the user would like medical alerts to print to.", "If no printers appear, click the ‘Update Printer List’ button to get the list of printers.", "After setting up how the user would like to receive medical alerts, the user may press the ‘Save’ button to save any changes.", "After loading the Security On Demand™ Manager site, click on the Reports tab (e.g., FIG.", "25).", "The user may choose the type of call the user want to display from the first dropdown menu.", "The second dropdown menu may allow the user to choose the type of report the user want.", "The user may filter the reports by selecting a start date and end date and clicking the ‘Filter Report’ button.", "This may list some or all of the calls that have occurred during that time.", "The user may clear out the filter by clicking the ‘Reset Filter’ button.", "The user may save a report by clicking the ‘Save Report’ button.", "This may create a report from the information that is currently displayed, taking into account the type of call, the type of report, and any filters applied.", "After the report is created a save dialog box may appear.", "This may allow the user to save the file locally.", "Valet on Demand (VOD) Enhanced Services Features and Management In at least one embodiment, “Valet On Demand®” (VOD) Service allows a patron to contact the valet services and notify of an estimated arrival time to have ones vehicle ready before they arrive in the vehicle pickup location.", "In at least some embodiments, the VOD service may also provide access to other casino services such as, for example: car service, transportation service, luggage service, air transportation service, tour service, etc.", "FIG.", "15 shows an example screenshot of a VOD Menu GUI 1500, in accordance with one embodiment.", "The example VOD Menu GUI illustrated in FIG.", "15 is configured as a frontend GUI which may be displayed and/or accessed by patrons via one or more EGM interfaces.", "FIGS.", "26-28 illustrate example screenshot embodiments of various Valet On Demand (VOD) Manager GUIs which may be configured or designed to enable a user (e.g., casino admin or manager) to access, manage, configure and/or modify various aspects, features, and parameters relating to the VOD Service(s).", "In some embodiments, one or more VOD Manager GUIs also may be configured or designed to enable a user (e.g., casino admin or manager) to access, monitor, track, and/or manage real-time status information relating to various aspects of the VOD Service.", "In at least one embodiment, the Valet On Demand™ Manager is where the user may setup the information needed to send alerts.", "Here the user may enter what email to send valet alerts from, as well as whether to receive the alerts through email, SMS, or printer.", "In order to access the Manager, navigate to the server that it was installed on.", "From here, the user may need to open up Internet Explorer.", "By default the homepage may be set to the Synergy Blue Apps page.", "If for some reason the home page has changed the apps page may be found at: localhost/appsite.", "Once the user has loaded up the app site the user may need to click on the ‘Valet On Demand™’ button.", "The Manager interface comprises of two sections: Tab Bar and Info Panel.", "The Tab Bar is where the user may navigate between the different tabs of the Valet On Demand™ Manager.", "The three tabs are: General Setup, Valet Setup, and Reports.", "The Info Panel provides some or all the information for the selected tab.", "The info panel may be used to view and edit information needed for at least one tab.", "The General Setup tab is where the user may input some or all the information for the sender's email.", "This is the email that the valet alerts may come from.", "The VOD service may be running in order to access the General Setup tab.", "After loading up the VOD™ Manager site the General Setup tab (e.g., FIG.", "26) may automatically be selected.", "The user may now begin filling out the General Setup fields.", "The first field to fill out is the port number.", "This is the port that is used to send emails.", "The default port is 587.This may not need to be changed.", "The second field to fill out is the actual email address of the sender.", "Example: myusername@email.com.", "The third field to fill out is the SMTP server address.", "This may be the address of the SMTP server the email address from the second field uses to send emails.", "Example: smtp.email.com.", "The fourth field to fill out is the username for the email account.", "This is the username needed to log into the email address provided in field two.", "The fifth and sixth field needed to fill out is the password for the email account.", "This is the password needed to log into the email address provided in field two.", "The fifth and sixth field may match in order to submit changes.", "The last thing needed to fill out is a dropdown box.", "This may be the default language Valet On Demand™ may use when loaded onto the EGM.", "After the user has filled out some or all of the fields press the ‘Save’ button to save the changes.", "The Valet Setup tab (e.g., FIG.", "27) is where the user may choose how the user wants to receive valet alerts.", "The Valet On Demand™ system is able to send alerts in three different ways: Email, SMS Message, and Printer.", "The VOD service may be running in order to access the Valet Setup tab.", "After loading up the Valet On Demand™ Manager site, click on the Valet Setup tab.", "This may load some or all of the information needed in the Info Panel.", "From here the user may select how the user would like to receive alerts.", "The user may choose one, however, the user may have some or all three selected if the user want.", "If the user chooses some or all three when someone uses Valet On Demand™ the user may get an email, SMS Message, and printed ticket.", "Checking the Email checkbox may bring up the email field.", "In this field the user may put the address of the email that the user would like to use to receive Valet alerts.", "Checking the SMS checkbox may bring up two fields: the phone number field, and the service provider dropdown box.", "In the phone number field the user may put the phone number where the user would like to receive valet alerts via SMS messages.", "In the service provider dropdown box, find the service provider for the number provided in the phone number field.", "To remove a service provider from the list select that provider in the dropdown list and click the ‘Remove Provider’ button.", "The final field may allow the user to add a provider to the dropdown list.", "Make sure the user include everything needed in the Mail to SMS gateway that follows the ‘@’ symbol, including the ‘@’ symbol itself at the beginning (example: @txt.att.net).", "Checking the Printer checkbox may bring up the printer dropdown box.", "Here the user may select a printer that the user would like valet alerts to print to.", "If no printers appear, or the list is out of date, click the ‘Update Printer List’ button to get the list of printers.", "After setting up how the user would like to receive valet alerts, the user may press the ‘Submit’ button to save any changes.", "The Reports tab (e.g., FIG.", "28) is where the user may be able to view some or all of the calls made by the Valet On Demand™ system.", "There are four different types of reports to view: Bank, Calls, Machine Number, and Player.", "The Bank Report may list how many calls at least one Bank ID has made.", "The Calls Report may list some or all of the individual calls made.", "The Machine Number Report may list how many calls at least one machine has made.", "The Player Report may list how many calls at least one player has made.", "After loading the Valet On Demand™ Manager site, click on the Reports tab.", "The user may choose the type of report the user want from the dropdown menu.", "The user may filter the reports by selecting a start date and end date and clicking the ‘Filter Report’ button.", "This may list some or all of the valet calls that have occurred during that time.", "The user may clear out the filter by clicking the ‘Reset Filter’ button.", "The user may save a report by clicking the ‘Save Report’ button.", "This may create a report from the information that is currently displayed, taking into account the type of report and any filters applied.", "Weather on Demand (WOD) Enhanced Services Features and Management In at least one embodiment, “Weather On Demand®” (WOD) Service allows a patron to view local weather (same day as well as multi day forecast) as well as world weather (which is searchable via a provided touch interface input panel).", "FIG.", "16 shows an example screenshot of a WOD Menu GUI 1600, in accordance with one embodiment.", "The example WOD Menu GUI illustrated in FIG.", "16 is configured as a frontend GUI which may be displayed and/or accessed by patrons via one or more EGM interfaces.", "FIG.", "29 illustrates an example screenshot embodiment of a Weather On Demand (WOD) Manager GUI which may be configured or designed to enable a user (e.g., casino admin or manager) to access, manage, configure and/or modify various aspects, features, and parameters relating to the WOD Service.", "In at least one embodiment, Weather On Demand has a Menu Manager similar to the rest of the On Demand applications and may be accessed through the AppSite interface.", "The Weather On Demand Manager interface layout comprises of two sections: Tab Bar and Info Panel.", "In some embodiments, the only tab for the WOD™ Manager is: General Setup (e.g., FIG.", "29).", "The Info Panel may provide some or all the information for the General Setup tab.", "The Info Panel may be used to view and edit the information of the General Setup tab.", "The General Setup tab is where the default information that is displayed on the EGM is configured.", "To configure the General Setup, there may be (5) sections to fill out: Default Language, Favored Country, Default Location, Measurement System, and API Key.", "The first field to fill out is Default Language.", "A dropdown menu is provided to select from the available list of supported languages.", "The second section is the Favored Country Setup.", "Select the desired favored country from the dropdown menu.", "The third section is Default Location.", "By typing the desired location into the input field, the website may automatically provide suggestions for default locations.", "Clicking the desired location suggestion may fill out the text field automatically.", "The fourth section is Default Measurement System.", "This may allow the user to configure the temperature and wind speed measurement display (F or C, mph or kph).", "To do so, click the radio button next to the desired measurement system.", "The fifth section is the API Key.", "This key is used to access World Weather Online™ weather API service.", "Type in the API key that the user received from registering World Weather Online™ into the API input field.", "Some or all changes may be saved before navigating away from the WOD™ Manager, to save any changes, click on the save button.", "The system may display a message indicating whether the save was successful or not.", "Other Features/Benefits/Advantages In at least some embodiments, the On Demand Services System may be configured, designed, and/or operable to provide, enable and/or facilitate one or more of the following features, functionalities, benefits and/or advantages (or combinations thereof): In some embodiments the ODS will run automated processes in which information from one (and/or multiple) database(s) such as, for example Infogenesis, Micros, etc.", "gets transferred to another.", "During these processes data is intelligently sorted and structured to run within the ODS framework.", "Allows current pre-existing property databases to be easily imported which in turn reduces down-time and seamlessly creates a unique dynamic property system using ODS.", "In some embodiments the ODS will not run automated processes and data may be entered and/or configured manually (if there is no pre-existing database and/or new content is being added).", "In such highly regulated systems as casinos, security is a number one priority.", "ODS utilizes secure networking with data encryption, password protection, serial number activation, etc.", "ODS complies with regulations and is tested and approved.", "as well as numerous formats where it can be implemented, formats include but are not limited to, pc's, tablets, smartphones, Google Glass, Windows Hololens, pit tables (terminals), G2S/S2S floors, Class 2/Class 3 machines, web-based systems, etc.", "Uses multiple code languages such as java, C++, HTML5, flash, C#, JSON, etc.", "which allows for deployment on nearly any platform.", "In some embodiments the “intelligence” of the system may be configured to monitor patron play and display custom offerings to help make the player feel special, unique, thought-of and involved.", "For example, in some current bonusing applications, the patron may receive an award/prize based on player card session points earned through play.", "In doing so, the patron is “enticed” to stay and play longer in order to get another bonus.", "With the ODS the possibility exists where the player could be prompted with custom messages that may “unlock” different items during different times, Or a different example, If a player is only betting minimum and based on the player card and tracking analytics, the system “knows” they are ordering beverages (and usually do so between x & y times) the system could display messaging that may state: “Max Bet Bar Bash!", "If you Max Bet within happy hour x, bar x offers top shelf drinks to ODS users .", ".", ".", "” The player doesn't have to max bet, nor are they required to.", "In some embodiments players, waitstaff, directors etc.", "can view order progress.", "From the player point of view, they may be allowed to track their order progress; see when its being delivered etc.", "Waitstaff can continually monitor their zones checking new, pending, delivered, player location change, etc.", "Directors can track waitstaff efficiency, times/averages of orders, etc.", "Closed loop functionality.", "Regardless if a patron decides to leave the property after ordering a drink, ODS tracks, and delivers real-time updates of card in/out events, order complete, order canceled, pre-defined time-outs etc.", "All of which are accounted for within the system and can be tracked and viewed at later times.", "Also the closed loop functionality provides ways wherein the waitstaff does not need to interfere with the patrons gaming screen, they can confirm order delivery with their mobile devices.", "The robust and dynamically flexible menu system allows a property to display items to the patrons exactly how they want.", "For example, Coffee could be offered multiple ways, one way would be to setup individual coffee setups, coffee/black, coffee/decaf, coffee/wCream, coffee/wCream&Sugar allowing the patron to select from a pre-defined list of options.", "Another way may be creating “condiment groups” based on food/drink/item/etc.", "categories which creates a different user experience, selecting coffee may then display all the available options that “belong” to coffee, such as, cream, sugar, amaretto, and by doing so, the patron gets to choose what they want.", "Pairing this with the systems “intelligent” features, ODS keeps track of the players custom drinks and allow easy/quick access to order the same in the future.", "If the ODS system is configured to work in an uncarded environment, some of its features may not be readily available (i.e.", "player card data) however the order process may be configured to send out SMS, email, messages that can notify waitstaff assigned to that zone of machines to locate the exact machine the request was sent from.", "The ODS system may be configured to work with tiered players, offering different items, pricing, etc.", "based on specific tier.", "In some embodiments ODS may be configured to display/track certain menu items.", "For example, foods in short supply and/or subject to market availability may have quantity numbers associated with them letting the patron know of the supply and demand of said items.", "Furthermore the OD S system can be configured to “auto-remove” said items should their quantity reach 0 and the system may also “auto-add” said item if it gets checked in by food & beverage director etc.", "As with any ordering system, orders can be canceled by both players and waitstaff etc.", "Configurable timers can be setup as well to automate the process, messaging may be displayed to inform the user(s) of order status.", "Patron able to access status update of ODS order via ODS GUI.", "In some embodiments an “order from your own device” option is available to patrons.", "Onsite players may login to a property website (onsite only) and order directly from there (i.e.", "if they are at a location that doesn't have a service window and/or kiosk).", "Geo-location and device tracking methods allow the waitstaff to pinpoint order locations.", "The features and dynamic framework of ODS is unmatched in the current casino industry.", "There exists a need for a single complete system that houses all of the players, employees and administrator's needs.", "OD S provides multiple solutions which are dynamic, flexible, robust and allows for complete customization no matter what the property may choose.", "Another feature of ODS is the customization freedom.", "A property can add their own branding, logos, colors, themes, sounds, ads, anything they desire in order to make ODS a seamless property system that matches their surroundings.", "In some embodiments ODS system allows for multiple versions of payments for items, cash, card (credit/debit), comp, coupons, Apple Pay, Google Wallet, etc.", "The On Demand Service techniques described herein enable casino patrons/customers to remain in their comfortable seat, wagering on their favorite game, and being able order food, drink, shirts, novelties.", "Whatever the casino decides to make available to the patron, also get security, weather, valet, medical assistance, and VIP host services without a hassle; on demand.", "Different embodiments of the On Demand Service techniques described herein may be adapted and implemented in a variety of environments.", "For example, the On Demand Service techniques described herein are particularly well suited for deployment in any business establishments that house wager-based gaming devices (e.g., class 3 and/or class 2).", "Additionally, the On Demand Service techniques described herein may appeal to younger gamblers/garners who enjoy playing arcade-style video games, middle aged gamblers/gamers who may have played some video games, and possibly even veteran gamblers who may be bored with existing wager-based video gaming technology.", "The On Demand Service techniques described herein provide the ability for patrons of casinos and other gaming establishments to experience new and exciting ways of engaging in wager-based video game play with minimized learning curve and intimidation factors.", "Additionally, using the On Demand Service techniques described herein, casinos and other gaming establishments hosting such On Demand Service devices may increase their revenue by ensuring that the number of wager-based gaming event(s) occurring in an On Demand (e.g., during specified time period) meet minimum specified threshold criteria.", "FIG.", "1 illustrates a simplified block diagram of a specific example embodiment of Casino Network 100 which may be configured or designed to implement one or more On Demand Services features described herein.", "As described in greater detail herein, different embodiments of Casino Networks may be configured, designed, and/or operable to provide various different types of operations, functionalities, and/or features generally relating to On Demand Services technology.", "According to different embodiments, at least some Casino Network(s) may be configured, designed, and/or operable to provide a number of different advantages and/or benefits and/or may be operable to initiate, and/or enable various different types of operations, functionalities, and/or features, such as, for example, one or more of those described and/or referenced herein.", "According to different embodiments, at least a portion of the various functions, actions, operations, and activities performed by one or more component(s) of the Casino Network may be initiated in response to detection of one or more conditions, events, and/or other criteria satisfying one or more different types of minimum threshold criteria, such as, for example, one or more of those described and/or referenced herein.", "According to different embodiments, at least a portion of the various types of functions, operations, actions, and/or other features provided by the Casino Network may be implemented at one or more mobile device(s), electronic gaming device(s), client systems(s), system servers(s), and/or combinations thereof.", "According to different embodiments, the Casino Network 100 may include a plurality of different types of components, devices, modules, processes, systems, etc., which, for example, may be implemented and/or instantiated via the use of hardware and/or combinations of hardware and software.", "For example, as illustrated in the example embodiment of FIG.", "1, the Casino Network may include one or more of the following types of systems, components, devices, processes, etc.", "(or combinations thereof): Display System Server(s) 104.In at least one embodiment, the Display System Server(s) may be configured or designed to implement and/or facilitate management of content (e.g., graphics, images, text, video fees, etc.)", "to be displayed and/or presented at one or more EGDs (or at one or more groups of EGDs), dealer displays, administrator displays, etc.", "EGD Multimedia System Server(s) 105.In at least one embodiment, the Table Multimedia System Server(s) may be configured or designed to generate, implement and/or facilitate management of content (e.g., graphics, images, text, video fees, audio feeds, etc.", "), which, for example, is to be streamed or provided to one or more EGDs (or to one or more groups of EGDs).", "Messaging System Server(s) 106.In at least one embodiment, the Messaging System Server(s) may be configured or designed to implement and/or facilitate management of messaging and/or other communications among and between the various systems, components, devices, EGDs, players, dealers, and administrators of the gaming network.", "Mobile System Server(s) 108.In at least one embodiment, the Mobile System Server(s) may be configured or designed to implement and/or facilitate management of communications and/or data exchanged with various types of mobile devices, including for example: player-managed mobile devices (e.g., smart phones, PDAs, tablets, mobile computers), casino-managed mobile devices (e.g., mobile gaming devices), etc.", "Financial System Server(s) 112.In at least one embodiment, the Financial System Server(s) may be configured or designed to implement and/or facilitate tracking, management, reporting, and storage of financial data and financial transactions relating to one or more On Demand sessions.", "For example, at least some Financial System Server(s) may be configured or designed to track financial transactions relating to On Demand Service(s) requested by or performed for different casino patrons (or other persons).", "Player Tracking System Server(s) 114.In at least one embodiment, the Player Tracking System Server(s) may be configured or designed to implement and/or facilitate management and exchange of player tracking information associated with one or more EGDs, On Demand sessions, etc.", "In at least one embodiment, a Player Tracking System Server may include at least one database that tracks at least one player's hands, wins/losses, bet amounts, player preferences, etc., in the network.", "In at least one embodiment, the presenting and/or awarding of promotions, bonuses, rewards, achievements, etc., may be based on a player's play patterns, time, games selected, bet amount for at least one game type, etc.", "A Player Tracking System Server may also help establish a player's preferences, which assists the casino in their promotional efforts to: award player comps (loyalty points); decide which promotion(s) are appropriate; generate bonuses; etc.", "Data Tracking & Analysis System(s) 118.In at least one embodiment, the Data Tracking & Analysis System(s) may be configured or designed to implement and/or facilitate management and analysis of game data.", "Additionally, the Data Tracking & Analysis System(s) may be configured or designed to track and analyze different transactions relating to different On Demand Service(s) requested by or performed for different casino patrons (or other persons).", "On Demand Services System 120.In at least one embodiment, the On Demand Services System may be configured or designed to implement and/or facilitate implementation, configuration, management, analysis, and reporting of On Demand Services including, for example, one or more of the following (or combinations thereof): Beverage On Demand Service(s); Host On Demand Service(s); Security On Demand Service(s); Valet On Demand Service(s); Weather On Demand Service(s); Reporting service(s); and/or other aspects of On Demand Services described and/or referenced herein.", "Gaming System Server(s) (122).", "In at least one embodiment, different game servers may be configured or designed to be dedicated to one or more specifically designated type(s) of game(s).", "At least one game server has game logic to host one of more On Demand Services sessions.", "Jurisdictional/Regulatory Monitoring & Enforcement System(s) 150.In at least one embodiment, the Jurisdictional/Regulatory Monitoring & Enforcement System(s) may be configured or designed to handle tracking, monitoring, reporting, and enforcement of specific regulatory requirements relating to wager-based gameplay activities in one or more jurisdictions.", "Authentication & Validation System(s) 152.According to different embodiments, the Authentication & Validation System(s) may be configured or designed to determine and/or authenticate the identity of the current player at a given EGD.", "For example, in one embodiment, the current player may be required to perform a log in process at the EGD in order to access one or more features.", "Alternatively, the EGD may be adapted to automatically determine the identity of the current player based upon one or more external signals such as, for example, scanning of a barcode of a player tracking card, an RFID tag or badge worn by the current player which provides a wireless signal to the EGD for determining the identity of the current player.", "In at least one implementation, various security features may be incorporated into the EGD to prevent unauthorized players from engaging in certain types of activities at the EGD.", "In some embodiments, the Authentication & Validation System(s) may be configured or designed to authenticate and/or validate various types of hardware and/or software components, such as, for example, hardware/software components residing at a remote EGDs, game play information, wager information, player information and/or identity, etc.", "Examples of various authentication and/or validation components are described in U.S. Pat.", "No.", "6,620,047, titled, “ELECTRONIC GAMING APPARATUS HAVING AUTHENTICATION DATA SETS,” incorporated herein by reference in its entirety for one or more purposes.", "Casino Venues.", "In at least one embodiment, at least one casino venue may correspond to a real-world, physical casino which is located at a particular geographic location.", "In some embodiments, a portion of the multiple different casino venues may be affiliated with at least one other (e.g., Harrah's Las Vegas, Harrah's London).", "In other embodiments, at least a portion of the multiple different casino venues do not share any affiliation with at least one other.", "In at least some embodiments, the Casino Network may span across multiple different Casino Venues.", "Remote Services.", "In at least some embodiments, remote services (e.g., provided by third parties) may be provided for implementing, facilitating, configuring, monitoring, updating, and/or reporting one or more On Demand Service(s)/feature(s).", "For example, in one embodiment, a third party may be provided access by a Casino establishment to remotely configure one or more On Demand Service(s)/feature(s) implemented at the Casino establishment's network.", "Electronic gaming devices (EGDs) 132.As described in greater detail herein, the EGDs may be configured or designed to facilitate and enable players to participate in wager-based gaming sessions.", "Additionally, the EGDs may be configured or designed to enable players to access one or more On Demand Services features.", "In some embodiments, the EGDs may be configured or designed to display one or more On Demand GUIs for facilitating patrons in accessing desired On Demand Services features.", "In some embodiments, different EGDs may be physically located in one or more different casino venues, and may be connected via a communication network.", "In some embodiments, EGDs may be implemented as stationary machines (as illustrated, for example, in FIG.", "10).", "In some embodiments, at least some EGDs may be implemented using mobile devices (e.g., tablets, smartphones, laptops, PC's, and the like).", "Electronic Gaming Tables 134.In at least some embodiments, the Electronic Gaming Tables may be configured or designed to enable players to access one or more On Demand Services features.", "Mobile Gaming Devices 136.In at least some embodiments, the Mobile Gaming Devices may be configured or designed to enable players to access one or more On Demand Services features.", "Data Network 110, which, for example, may include one or more of the following (or combinations thereof): Internet Network(s), Cellular Network(s), WAN Network(s), LAN Network(s), and/or other types of communication networks.", "Game History Server(s) 164.In at least one embodiment, the Game History Server(s) may be configured or designed to track one or more (or selected) game types and game play history for one or more (or selected) On Demands In some embodiments, a Game History Server may also assist the casino manager in case of disputes between players and the casino by, for example, providing the ability to “replay” (e.g., by virtually recreating the game events) the game in dispute, step by step, based on previously stored game states.", "Such dispute resolution capability is a desirable feature in On Demand environments.", "Remote Database System(s) which, for example, may be operable to store and provide access to various types of information and data described herein.", "Remote System Server(s)/Service(s), which, for example, may include, but are not limited to, one or more of the following (or combinations thereof): Content provider servers/services Media Streaming servers/services Database storage/access/query servers/services Financial transaction servers/services Payment gateway servers/services Electronic commerce servers/services Event management/scheduling servers/services Etc.", "In at least one embodiment, the Casino Network may be operable to utilize and/or generate various different types of data and/or other types of information when performing specific tasks and/or operations.", "This may include, for example, input data/information and/or output data/information.", "For example, in at least one embodiment, the Casino Network may be operable to access, process, and/or otherwise utilize information from one or more different types of sources, such as, for example, one or more local and/or remote memories, devices and/or systems.", "Additionally, in at least one embodiment, the Casino Network may be operable to generate one or more different types of output data/information, which, for example, may be stored in memory of one or more local and/or remote devices and/or systems.", "Examples of different types of input data/information and/or output data/information which may be accessed and/or utilized by the Casino Network may include, but are not limited to, one or more of those described and/or referenced herein.", "According to specific embodiments, multiple instances or threads of the On Demand Service(s) may be concurrently implemented and/or initiated via the use of one or more processors and/or other combinations of hardware and/or hardware and software.", "For example, in at least some embodiments, various aspects, features, and/or functionalities of the On Demand Service(s) may be performed, implemented and/or initiated by one or more of the various systems, components, systems, devices, procedures, processes, etc., described and/or referenced herein.", "In at least one embodiment, a given instance of the Casino Network may access and/or utilize information from one or more associated databases.", "In at least one embodiment, at least a portion of the database information may be accessed via communication with one or more local and/or remote memory devices.", "Examples of different types of data which may be accessed by the Casino Network may include, but are not limited to, one or more of those described and/or referenced herein.", "According to different embodiments, various different types of encryption/decryption techniques may be used to facilitate secure communications between various devices, components and/or systems of the Casino Network(s).", "Examples of the various types of security techniques which may be used may include, but are not limited to, one or more of the following (or combinations thereof): random number generators, SHA-1 (Secured Hashing Algorithm), MD2, MD5, DES (Digital Encryption Standard), 3DES (Triple DES), RC4 (Rivest Cipher), ARC4 (related to RC4), TKIP (Temporal Key Integrity Protocol, uses RC4), AES (Advanced Encryption Standard), RSA, DSA, DH, NTRU, and ECC (elliptic curve cryptography), PKA (Private Key Authentication), Device-Unique Secret Key and other cryptographic key data, SSL, etc.", "Other security features contemplated may include use of well-known hardware-based and/or software-based security components, and/or any other known or yet to be devised security and/or hardware and encryption/decryption processes implemented in hardware and/or software.", "According to different embodiments, one or more different instances or threads of the On Demand Service(s) may be initiated in response to detection of one or more conditions or events satisfying one or more different types of minimum threshold criteria for triggering initiation of at least one instance of the Casino Network.", "Various examples of conditions or events which may trigger initiation and/or implementation of one or more different threads or instances of the instances or threads of the On Demand Service(s) may include, but are not limited to, one or more of those described and/or referenced herein.", "It may be appreciated that the Casino Network of FIG.", "1 is but one example from a wide range of Casino Network embodiments which may be implemented.", "Other embodiments of the Casino Network (not shown) may include additional, fewer and/or different components/features that those illustrated in the example Casino Network embodiment of FIG.", "1.Generally, the instances or threads of the On Demand Service(s) described herein may be implemented in hardware and/or hardware+software.", "For example, they may be implemented in an operating system kernel, in a separate user process, in a library package bound into network applications, on a specially constructed machine, or on a network interface card.", "In a specific embodiment, various aspects described herein may be implemented in software such as an operating system or in an application running on an operating system.", "Hardware and/or software+hardware hybrid embodiments of the instances or threads of the On Demand Service(s) techniques described herein may be implemented on a general-purpose programmable machine selectively activated or reconfigured by a computer program stored in memory.", "Such programmable machine may include, for example, mobile or handheld computing systems, PDA, smart phones, notebook computers, tablets, netbooks, desktop computing systems, system servers, cloud computing systems, network devices, etc.", "FIG.", "1 illustrates a network diagram of an example embodiment of a Casino Network 100 which may be configured or designed to implement various instances or threads of the On Demand Service(s) techniques described and/or referenced herein.", "As described in greater detail herein, different embodiments of instances or threads of the On Demand Service(s) may be configured, designed, and/or operable to provide various different types of operations, functionalities, and/or features generally relating to On Demand Services technology.", "Further, as described in greater detail herein, many of the various operations, functionalities, and/or features of the instances or threads of the On Demand Service(s) disclosed herein may provide may enable or provide different types of advantages and/or benefits to different entities interacting with the Casino Network(s).", "According to specific embodiments, a variety of different game states may be used to characterize the state of current and/or past events which are occurring (or have occurred) at a given EGD.", "For example, in one embodiment, at any given time in a game, a valid current game state may be used to characterize the state of game play (and/or other related events, such as, for example, mode of operation of the EGD, etc.)", "at that particular time.", "In at least one embodiment, multiple different states may be used to characterize different states or events which occur at the EGD at any given time.", "In one embodiment, when faced with ambiguity of game state, a single state embodiment forces a decision such that one valid current game state is chosen.", "In a multiple state embodiment, multiple possible game states may exist simultaneously at any given time in a game, and at the end of the game or at any point in the middle of the game, the EGD may analyze the different game states and select one of them based on certain criteria.", "Thus, for example, when faced with ambiguity of game state, the multiple state embodiment(s) allow one or more potential game states to exist and move forward, thus deferring the decision of choosing one game state to a later point in the game.", "The multiple game state embodiment(s) may also be more effective in handling ambiguous data or game state scenarios.", "According to specific embodiments, a variety of different entities may be used (e.g., either singly or in combination) to track the progress of game states which occur at a given gaming EGD.", "Examples of such entities may include, but are not limited to, one or more of the following (or combination thereof): master controller system, display system, gaming system, local game tracking component(s), remote game tracking component(s), etc.", "Examples of various game tracking components may include, but are not limited to: automated sensors, manually operated sensors, video cameras, intelligent playing card shoes, RFID readers/writers, RFID tagged chips, objects displaying machine readable code/patterns, etc.", "According to a specific embodiment, local game tracking components at the EGD may be operable to automatically monitor game play activities at the EGD, and/or to automatically identify key events which may trigger a transition of game state from one state to another as a game progresses.", "FIG.", "2 shows an example block diagram of an alternate embodiment of a Casino Network 200 in accordance with a specific embodiment.", "As illustrated in the example embodiment of FIG.", "2, Casino Network 200 may include: A first plurality of device(s), component(s), system(s), which may function as part of the Casino Network's Backend System 280.In at least one embodiment, access to Casino Network's Backend System may be intended for (or restricted to) authorized personnel such as, for example, Casino staff, Casino Employees, security personnel, authorized users, authorized remote users, authorized remote systems, etc.", "A second plurality of device(s), component(s), system(s), which may function as part of the Casino Network's Frontend System.", "In at least one embodiment, access to Casino Network's Frontend System may be intended for casino patrons, players, hotel guests, end users, etc.", "In at least one embodiment, the Frontend System may include electronic gaming devices 132, electronic gaming tables 134 and/or mobile gaming devices 136 which are located in one or more of the Casino's gaming floors/regions.", "In at least some embodiments, the electronic gaming machines and other devices on the casino gaming floor may be used by authorized personnel to remotely access one or more device(s), component(s), system(s) of the Backend System.", "In at least some embodiments, other device(s), component(s), system(s) of the casino network (e.g., such as mobile devices, laptops, smartphones, tablets, etc.)", "may function as either a Frontend System device or a Backend System device, depending upon the user, and functionality being accessed.", "For example, a casino patron may use his or her smartphone in various regions of the casino (including, for example, non-gaming regions such as the pool, hotel room, restaurant, etc.)", "to access the Frontend of the On Demand Services System.", "In other embodiments, a casino employee (such as a hostess or waitress) may use his or her smartphone to access the Backend of the On Demand Services System.", "According to different embodiments, the Casino Network 200 may include a plurality of different types of components, devices, modules, processes, systems, etc., which, for example, may be implemented and/or instantiated via the use of hardware and/or combinations of hardware and software.", "For example, as illustrated in the example embodiment of FIG.", "2, the Casino Network may include one or more of the following types of systems, components, devices, processes, etc.", "(or combinations thereof): Electronic gaming devices 132; Electronic gaming tables 134; Mobile gaming devices 136; Network links 210; Network 205, which, for example, may include WANs and/or LANs; Accounting/transaction server 220 may compile, track, store, and/or monitor cash flows, voucher transactions, winning vouchers, losing vouchers, and/or other transaction data for the casino operator and for the players.", "Transaction data may include the number of wagers, the size of these wagers, the date and time for these wagers, the identity of the players making these wagers, and the frequency of the wagers.", "Accounting/transaction server 220 may generate tax information relating to these wagers.", "Accounting/transaction server 220 may generate profit/loss reports for predetermined gaming options, contingent gaming options, predetermined betting structures, and/or outcome categories.", "Gaming server 225 may generate gaming options based on predetermined betting structures and/or outcome categories.", "These gaming options may be predetermined gaming options, contingent gaming options, and/or any other gaming option disclosed in this disclosure.", "Authentication server 230 may determine the validity of vouchers, players' identity, and/or an outcome for a gaming event.", "Player tracking server 235 may track a player's betting activity, a player's preferences (e.g., language, drinks, font, sound level, etc.).", "Based on data obtained by player tracking server 235, a player may be eligible for gaming rewards (e.g.", "free play), promotions, and/or other awards (e.g., complimentary food, drinks, lodging, concerts, etc.).", "Voucher server 240 may generate a voucher, which may include data relating to gaming options.", "For example, data relating to the structure may be generated.", "If there is a time deadline, that information may be generated by voucher server 240.Vouchers may be physical (e.g., paper) or digital.", "Searching server 242 may implement a search on one or more gaming devices to obtain gaming data.", "Searching server 242 may implement a messaging function, which may transmit a message to a third party (e.g., a player) relating to a search, a search status update, a game status update, a wager status update, a confirmation of a wager, a confirmation of a money transfer, and/or any other data relating to the player's account.", "The message may take the form of a text display on the gaming device, a pop up window, a text message, an email, a voice message, a video message and the like.", "Searching server 242 may implement a wagering function, which may be an automatic wagering mechanism.", "These functions of searching server 242 may be integrated into one or more servers.", "Searching server 242 may include one or more searching structures, one or more searching algorithms, and/or any other searching mechanisms.", "In general, the search structures may cover which Gaming Devices paid out the most money during a time period, which Gaming Devices kept the most money from players during a time period, which Gaming Devices are most popular (top games), which Gaming Devices are least popular, which Gaming Devices have the most amount of money wager during a period, which Gaming Devices have the highest wager volume, which Gaming Devices are more volatile (volatility, or deviation from the statistical norms, of wager volume, wager amount, pay out, etc.)", "during a time period, and the like.", "Search may also be associated with location queries, time queries, and/or people queries.", "The searching structures may be predetermined searching structures.", "For example, the method may start searching a first device, then a second device, then a third device, up to an Nth device based on one or more searching parameters (e.g., triggering event).", "In one example, the search may end once one or more triggering events are determined.", "In another example, the search may end once data has been received from a predetermined number (e.g., one, two, ten, one hundred, one or more) of the devices.", "In another example, the search may be based on a predetermined number of devices to be searched in combination with a predetermined number of search results to be obtained.", "In this example, the search structure may be a minimum of ten devices to be searched, along with a minimum of five gaming options to be determined.", "In another example, the searching structures may be based on one or more specific game types and/or themes (e.g., first person shooter types, first person rail types, TV themes, Movie themes, multiplayer types, etc.).", "Searching structure may search one or more of these games.", "In another example, the searching structure may be based on a player's preferences, past transactional history, player input, a particular game, a particular EGD, a particular casino, a particular location within a casino, game outcomes over a time period, payout over a time period, and/or any other criteria.", "Searching algorithms may be dynamic searching programs, which may be modified based on one or more past results.", "In one example, the search algorithm may determine that a specific triggering event occurs with a ninety percent success rate on a first EGD, a ten percent success rate on a second EGD, a fifty percent success rate on a third EGD, and a seventy percent success rate on a fourth EGD.", "The search algorithm may generate a search priority based on the probability of success, which may lead to the first EGD being searched first, the fourth EGD being searched second, the third EGD being searched third, and the second EGD being searched fourth.", "Search algorithm may utilize any dynamic feedback procedure to enhance current and/or future searching results FIG.", "3 shows a perspective view of an example gaming machine 302 in accordance with a specific embodiment.", "As illustrated in the example of FIG.", "3, device 302 includes a main cabinet or housing 304, which generally surrounds the device interior and is viewable by users.", "The main cabinet includes an access door 308, which opens to provide access to the interior of the device.", "In particular embodiments, the gaming machine may be controlled by software executed by a master gaming controller 346 in conjunction with software executed by a remote logic device (e.g., a remote host, a central server or a central controller) in communication with the gaming machine.", "The master gaming controller may execute externally-controlled interface (ECI) processes which, for example, may enable content generated and managed on the remote host to be output on the gaming machine.", "The gaming machine may receive and send events to the remote host that may affect the content output by one or more ECI processes as well as enable an ECI process to be initiated on the gaming machine.", "In one embodiment, attached to the main door is at least one payment acceptor 328 and a bill validator 330, and a coin tray 338.In one embodiment, the payment acceptor may include a coin slot and a payment, note or bill acceptor, where the player inserts money, coins or tokens.", "The player can place coins in the coin slot or paper money, a ticket or voucher into the payment, note or bill acceptor.", "In other embodiments, devices such as readers or validators for credit cards, debit cards or credit slips may accept payment.", "In one embodiment, a player may insert an identification card into a card reader of the gaming machine.", "In one embodiment, the identification card is a smart card having a programmed microchip or a magnetic strip coded with a player's identification, credit totals (or related data) and other relevant information.", "In another embodiment, a player may carry a portable device, such as a cell phone, a radio frequency identification tag or any other suitable wireless device, which communicates a player's identification, credit totals (or related data) and other relevant information to the gaming machine.", "In one embodiment, money may be transferred to a gaming machine through electronic funds transfer.", "When a player funds the gaming machine, the master gaming controller 346 or another logic device coupled to the gaming machine determines the amount of funds entered and displays the corresponding amount on the credit or other suitable display as described above.", "In one embodiment attached to the main door are a plurality of player-input switches or buttons 332.The input switches can include any suitable devices which enables the player to produce an input signal which is received by the processor.", "In one embodiment, after appropriate funding of the gaming machine, the input switch is a game activation device, such as a pull arm or a play button which is used by the player to start any primary game or sequence of events in the gaming machine.", "The play button can be any suitable play activator such as a bet one button, a max bet button or a repeat the bet button.", "In one embodiment, upon appropriate funding, the gaming machine may begin the game play automatically.", "In another embodiment, upon the player engaging one of the play buttons, the gaming machine may automatically activate game play.", "In one embodiment, one input switch is a bet one button.", "The player places a bet by pushing the bet one button.", "The player can increase the bet by one credit each time the player pushes the bet one button.", "When the player pushes the bet one button, the number of credits shown in the credit display preferably decreases by one, and the number of credits shown in the bet display preferably increases by one.", "In another embodiment, one input switch is a bet max button (not shown), which enables the player to bet the maximum wager permitted for a game of the gaming machine.", "In one embodiment, one input switch is a cash-out button.", "The player may push the cash-out button and cash out to receive a cash payment or other suitable form of payment corresponding to the number of remaining credits.", "In one embodiment, when the player cashes out, the player may receive the coins or tokens in a coin payout tray.", "In one embodiment, when the player cashes out, the player may receive other payout mechanisms such as tickets or credit slips redeemable by a cashier (or other suitable redemption system) or funding to the player's electronically recordable identification card.", "Details of ticketing or voucher system that may be utilized with at least one embodiment described herein are described in co-pending U.S. patent application Ser.", "No.", "10/406,911, filed Apr.", "2, 2003, by Rowe, et al., and entitled, “Cashless Transaction Clearinghouse,” which is incorporated herein by reference and for all purposes.", "In one embodiment, one input switch is a touch-screen coupled with a touch-screen controller, or some other touch-sensitive display overlay to enable for player interaction with the images on the display.", "The touch-screen and the touch-screen controller may be connected to a video controller.", "A player may make decisions and input signals into the gaming machine by touching touch-screen at the appropriate places.", "One such input switch is a touch-screen button panel.", "In one embodiment, the gaming machine may further include a plurality of communication ports for enabling communication of the gaming machine processor with external peripherals, such as external video sources, expansion buses, game or other displays, an SCSI port or a key pad.", "According to different embodiments, the gaming machine may be configured or designed to present one or more On Demand GUIs (e.g., via the gaming machine display(s), see, e.g., FIGS.", "10-21) to thereby enable players or patrons to access one or more On Demand Service(s)/feature(s) such as those described herein.", "As seen in FIG.", "3, viewable through the main door is a video display monitor 334 and an information panel 336.The display monitor 334 will typically be a cathode ray tube, high resolution flat-panel LCD, OLED based-display, plasma display, a television display, a display based on light emitting diodes (LED), a display based on polymer light-emitting diodes (PLEDs), a display including a projected and/or reflected image or any other suitable electronic device or display.", "The information panel 336 or belly-glass 340 may be a static back-lit, silk screened glass panel with lettering to indicate general game information including, for example, a game denomination (e.g.", "$0.25 or $1) or a dynamic display, such as an LCD, an OLED or E-INK display.", "In another embodiment, at least one display device may be a mobile display device, such as a PDA or tablet PC, that enables play of at least a portion of the primary or secondary game at a location remote from the gaming machine.", "The display devices may be of any suitable size and configuration, such as a square, rectangle elongated rectangle.", "The display devices of the gaming machine are configured to display at least one and preferably a plurality of game or other suitable images, symbols and indicia such as any visual representation or exhibition of the movement of objects such as mechanical, virtual or video reels and wheels, dynamic lighting, video images, images of people, characters, places, things and faces of cards, and the like.", "In one alternative embodiment, the symbols, images and indicia displayed on or of the display device may be in mechanical form.", "That is, the display device may include any electromechanical device, such as one or more mechanical objects, such as one or more rotatable wheels, reels or dice, configured to display at least one or a plurality of game or other suitable images, symbols or indicia.", "In another embodiment, the display device may include an electromechanical device adjacent to a video display, such as a video display positioned in front of a mechanical reel.", "In another embodiment, the display device may include dual layered video displays which co-act to generate one or more images.", "The bill validator 330, player-input switches 332, video display monitor 334, and information panel are gaming machines that may be used to play a game on the game device 302.Also, these devices may be utilized as part of an ECI provided on the gaming machine.", "According to a specific embodiment, the devices may be controlled by code executed by a master gaming controller 346 housed inside the main cabinet 304 of the device 302.The master gaming controller may include one or more processors including general purpose and specialized processors, such as graphics cards, and one or more memory devices including volatile and non-volatile memory.", "The master gaming controller 346 may periodically configure and/or authenticate the code executed on the gaming machine.", "In one embodiment, the gaming machine may include a sound generating device coupled to one or more sounds cards.", "In one embodiment, the sound generating device includes at least one and preferably a plurality of speakers or other sound generating hardware and/or software for generating sounds, such as playing music for the primary and/or secondary game or for other modes of the gaming machine, such as an attract mode.", "In one embodiment, the gaming machine provides dynamic sounds coupled with attractive multimedia images displayed on one or more of the display devices to provide an audio-visual representation or to otherwise display full-motion video with sound to attract players to the gaming machine.", "During idle periods, the gaming machine may display a sequence of audio and/or visual attraction messages to attract potential players to the gaming machine.", "The videos may also be customized for or to provide any appropriate information.", "In one embodiment, the gaming machine may include a sensor, such as a camera that is selectively positioned to acquire an image of a player actively using the gaming machine and/or the surrounding area of the gaming machine.", "In one embodiment, the camera may be configured to selectively acquire still or moving (e.g., video) images and may be configured to acquire the images in either an analog, digital or other suitable format.", "The display devices may be configured to display the image acquired by the camera as well as display the visible manifestation of the game in split screen or picture-in-picture fashion.", "For example, the camera may acquire an image of the player and the processor may incorporate that image into the primary and/or secondary game as a game image, symbol or indicia.", "In another embodiment, the gaming machines on the gaming machine may be controlled by code executed by the master gaming controller 346 (or another logic device coupled to or in communication with the gaming machine, such as a player tracking controller) in conjunction with code executed by a remote logic device in communication with the master gaming controller 346.In at least one embodiment, the master gaming controller 346 may execute ECI processes that enable content generated and managed on a remote host to be output on the gaming machine.", "The gaming machine may receive and send events to a remote host that may affect the content output on an instantiation of a particular ECI.", "The master gaming controller 346 may be configured to limit the resources that can be utilized by the ECI processes executing on the gaming machine at any given time and may constantly monitor resources utilized by the ECI processes to ensure that gaming experience on the gaming machine is optimal Games Played Many different types of wager-based games, including mechanical slot games, video slot games, video poker, video black jack, video pachinko, lottery, etc., may be played via the use of one or more gaming devices and/or gaming systems described or referenced herein.", "In particular, the gaming machine 302 may be operable to provide a play of many different games of chance.", "The games may be differentiated according to themes, sounds, graphics, type of game (e.g., slot game vs. card game), denomination, number of paylines, maximum jackpot, progressive or non-progressive, bonus games, etc.", "In one embodiment, the gaming machine 302 may be operable to enable a player to select a game of chance to play from a plurality of different games available on the gaming machine.", "For example, the gaming machine may provide a menu with a list of the different games that are available for play on the gaming machine and a player may be able to select from the list a first game of chance that they wish to play.", "In one such embodiment, a In particular embodiments, the master gaming controller 346 may provide information to a remote host providing content to an ECI on the gaming machine 302 that enables the remote host to select graphical and audio themes for the ECI content that matches the theme of the game graphics and game sounds currently played on the gaming machine 302.In one embodiment, the various games available for play on the gaming machine 302 may be stored as game software on a mass storage device in the gaming machine.", "In one such embodiment, the memory device of the gaming machine stores program codes and instructions, executable by the gaming machine processor, to control the games available for play on the gaming machine.", "The memory device also stores other data such as image data, event data, player input data, random or pseudo-random number generators, pay-table data or information and applicable game rules that relate to the play of the gaming machine.", "In another embodiment, the games available for play on the gaming machine may be generated on a remote gaming machine but then displayed on the gaming machine.", "In one embodiment, the gaming machine 302 may execute game software, such as but not limited to video streaming software that enables the game to be displayed on the gaming machine.", "When a game is stored on the gaming machine 302, it may be loaded from the mass storage device into a RAM for execution.", "In some cases, after a selection of a game, the game software that enables the selected game to be generated may be downloaded from a remote gaming machine, such as another gaming machine.", "As illustrated in the example of FIG.", "3, the gaming machine 302 includes a top box 306, which sits on top of the main cabinet 304.The top box 306 houses a number of devices, which may be used to add features to a game being played on the gaming machine 302, including speakers 310, 312, 314, a ticket printer 318 which prints bar-coded tickets 320, a key pad 322 for entering player tracking information, a display 316 (e.g., a video LCD display) for displaying player tracking information, a card reader 324 for entering a magnetic striped card containing player tracking information, and a video display screen 35.The ticket printer 318 may be used to print tickets for a cashless ticketing system.", "Further, the top box 306 may house different or additional devices not illustrated in FIG.", "3.For example, the top box may include a bonus wheel or a back-lit silk screened panel which may be used to add bonus features to the game being played on the gaming machine.", "As another example, the top box may include a display for a progressive jackpot offered on the gaming machine.", "During a game, these devices are controlled and powered, in part, by circuitry (e.g.", "a master gaming controller 346) housed within the main cabinet 304 of the device 302.It will be appreciated that gaming machine 302 is but one example from a wide range of gaming machine designs on which at least one embodiment described herein may be implemented.", "For example, not all suitable gaming machines have top boxes or player tracking features.", "Further, some gaming machines have only a single game display—mechanical or video, while others may have multiple displays.", "Networks In various embodiments, the remote gaming machine may be connected to the host computer via a network of some type such as a local area network, a wide area network, an intranet or the Internet.", "In one such embodiment, a plurality of the gaming machines may be capable of being connected together through a data network.", "In one embodiment, the data network is a local area network (LAN), in which one or more of the gaming machines are substantially proximate to each other and an on-site remote host as in, for example, a gaming establishment or a portion of a gaming establishment.", "In another embodiment, the data network is a wide area network (WAN) in which one or more of the gaming machines are in communication with at least one off-site remote host.", "In this embodiment, the plurality of gaming machines may be located in a different part of the gaming establishment or within a different gaming establishment than the off-site remote host.", "Thus, the WAN may include an off-site remote host and an off-site gaming machine located within gaming establishments in the same geographic area, such as a city or state.", "The WAN gaming system may be substantially identical to the LAN gaming system described above, although the number of gaming machines in each system may vary relative to each other.", "In another embodiment, the data network is an internet or intranet.", "In this embodiment, the operation of the gaming machine can be viewed at the gaming machine with at least one internet browser.", "In this embodiment, operation of the gaming machine and accumulation of credits may be accomplished with only a connection to the central server or controller (the internet/intranet server) through a conventional phone or other data transmission line, digital line (DSL), T-1 line, coaxial cable, fiber optic cable, or other suitable connection.", "In this embodiment, players may access an internet game page from any location where an internet connection and computer, or other internet facilitator is available.", "The expansion in the number of computers and number and speed of internet connections in recent years increases opportunities for players to play from an ever-increasing number of remote sites.", "It should be appreciated that enhanced bandwidth of digital wireless communications may render such technology suitable for some or all communications, particularly if such communications are encrypted.", "Higher data transmission speeds may be useful for enhancing the sophistication and response of the display and interaction with the player.", "In another embodiment, the remote gaming machine may be a portable gaming machine such as but not limited to a cell phone, a personal digital assistant, and a wireless game player Images rendered from 3-D gaming environments may be displayed on portable gaming machines that are used to play a game of chance.", "Further a gaming machine or server may include gaming logic for commanding a remote gaming machine to render an image from a virtual camera in a 3-D gaming environments stored on the remote gaming machine and to display the rendered image on a display located on the remote gaming machine.", "In addition, various combinations of gaming machines are possible on the gaming machine.", "For example, some gaming machine only accept cash, cashless vouchers or electronic fund transfers and do not include coin acceptors or coin hoppers.", "Thus, those of skill in the art will understand that at least one embodiment described herein, as described below, can be deployed on most any gaming machine now available or hereafter developed.", "In another embodiment, the gaming machine disclosed herein is operable over a wireless network, such as part of a wireless gaming system.", "In this embodiment, the gaming machine may be a hand held device, a mobile device or any other suitable wireless device that enables a player to play any suitable game at a variety of different locations.", "It should be appreciated that a gaming machine as disclosed herein may be a device that has obtained approval from a regulatory gaming commission or a device that has not obtained approval from a regulatory gaming commission.", "In at least one embodiment, some wager-based gaming systems may enable functionality relating to other game play concepts/features such as, for example: tournament play with multiple tables; head to head play on and/or between tables; etc.", "This is in addition to the simple social factor of allowing people to play together on a table, versus playing against each other or against a dealer.", "Also, it opens the door for traditional types of player input and/or real-time object recognition.", "For example, players can simply gesture to make something happen, versus pressing a button.", "For example, in one embodiment, a game of blackjack may be played on an intelligent multi-player electronic gaming system, and a player may be able to split their hand (e.g., of paired 8's) by simply placing their fingers over the virtual cards and spreading their cards out to cause the computer to recognize the split action.", "According to different embodiments, a wager-based gaming system may be operable as a stand alone device, and/or it can be operable as a server-based device.", "It can also plug into multi-player platforms.", "In at least one embodiment, some wager-based gaming systems support industry standard software development with WPF (Windows Presentation Foundation), Expressions Blend (for the artists), and Microsoft's XNA, which is used to make PC and XBox games.", "It will be appreciated that the various wager-based gaming systems described herein are but some examples from a wide range of wager-based gaming systems designs on which various aspects and/or techniques described herein may be implemented.", "For example, not all wager-based gaming systems have electronic displays or player tracking features.", "Further, some wager-based gaming systems may include a single display, while others may include multiple displays.", "Other wager-based gaming systems may not include any displays.", "As another example, a game may be generated on a host computer and may be displayed on a remote terminal or a remote gaming device.", "The remote gaming device may be connected to the host computer via a network of some type such as a local area network, a wide area network, an intranet or the Internet.", "The remote gaming device may be a portable gaming device such as but not limited to a cell phone, a personal digital assistant, and a wireless game player.", "Images rendered from gaming environments may be displayed on portable gaming devices that are used to facilitate game play activities at the wager-based gaming system.", "Further a wager-based gaming system or server may include gaming logic for commanding a remote gaming device to render an image from a virtual camera in 2-D or 3-D gaming environments stored on the remote gaming device and to display the rendered image on a display located on the remote gaming device.", "Thus, those of skill in the art will understand that the various example embodiments described herein may be deployed on most any wager-based gaming system now available or hereafter developed.", "Gaming device vs.", "General-Purpose Computer Some preferred wager-based gaming devices of the present assignee are implemented with special features and/or additional circuitry that differentiates them from general-purpose computers (e.g., desktop PC's and laptops).", "In at least one embodiment, a wager-based gaming device may be defined to include any type of device, machine, apparatus, and/or system which has been configured or designed for use in conducting wager-based game play activities at the wager-based gaming device.", "Example of such wager-based gaming device may include, but are not limited to, one or more of the following (or combinations thereof): mechanical gaming machines, electronic gaming machines, slot-type gaming machines, gaming tables, mobile or portable wager-based gaming devices, etc.", "Wager-based gaming devices are highly regulated to ensure fairness and, in some cases, wager-based gaming devices are operable to dispense monetary awards of multiple millions of dollars.", "Therefore, to satisfy security and regulatory requirements in a gaming environment, hardware and software architectures may be implemented in wager-based gaming devices that differ significantly from those of general-purpose computers.", "A description of wager-based gaming devices relative to general-purpose computing devices and some examples of the additional (or different) components and features found in wager-based gaming devices are described below.", "At first glance, one might think that adapting PC technologies to the gaming industry would be a simple proposition because both PCs and wager-based gaming devices employ microprocessors that control a variety of devices.", "However, because of such reasons as 1) the regulatory requirements that are placed upon wager-based gaming devices, 2) the harsh environment in which wager-based gaming devices operate, 3) security requirements and 4) fault tolerance requirements, adapting PC technologies to a wager-based gaming device can be quite difficult.", "Further, techniques and methods for solving a problem in the PC industry, such as device compatibility and connectivity issues, might not be adequate in the gaming environment.", "For instance, a fault or a weakness tolerated in a PC, such as security holes in software or frequent crashes, may not be tolerated in a wager-based gaming device because in a wager-based gaming device these faults can lead to a direct loss of funds from the wager-based gaming device, such as stolen cash or loss of revenue when the wager-based gaming device is not operating properly.", "For the purposes of illustration, a few differences between PC systems and wager-based gaming devices/systems will be described.", "A first difference between wager-based gaming devices and common PC based computers systems is that wager-based gaming devices are designed to be state-based systems.", "In a state-based system, the system stores and maintains its current state in a non-volatile memory, such that, in the event of a power failure or other malfunction the wager-based gaming device will return to its current state when the power is restored.", "For instance, if a player was shown an award for a wager-based game (e.g., of chance, skill and/or some combination thereof) and, before the award could be provided to the player the power failed, the wager-based gaming device, upon the restoration of power, would return to the state where the award is indicated.", "As anyone who has used a PC, knows, PCs are not state devices and a majority of data is usually lost when a malfunction occurs.", "This requirement affects the software and hardware design on a wager-based gaming device.", "A second important difference between wager-based gaming devices and common PC based computer systems is that for regulation purposes, the software on the wager-based gaming device used to generate the wager-based game and operate the wager-based gaming device has been designed to be static and monolithic to prevent cheating by the operator of wager-based gaming device.", "For instance, one solution that has been employed in the gaming industry to prevent cheating and satisfy regulatory requirements has been to manufacture a wager-based gaming device that can use a proprietary processor running instructions to generate the wager-based game play activities from an EPROM or other form of non-volatile memory.", "The coding instructions on the EPROM are static (non-changeable) and must be approved by a gaming regulators in a particular jurisdiction and installed in the presence of a person representing the gaming jurisdiction.", "Any changes to any part of the software required to generate the wager-based game play activities, such as adding a new device driver used by the master gaming controller to operate a device during generation of the wager-based game can require a new EPROM to be burnt, approved by the gaming jurisdiction and reinstalled on the wager-based gaming device in the presence of a gaming regulator.", "Regardless of whether the EPROM solution is used, to gain approval in most gaming jurisdictions, a wager-based gaming device must demonstrate sufficient safeguards that prevent an operator or player of a wager-based gaming device from manipulating hardware and software in a manner that gives them an unfair and some cases an illegal advantage.", "The wager-based gaming device should have a means to determine if the code it will execute is valid.", "If the code is not valid, the wager-based gaming device must have a means to prevent the code from being executed.", "The code validation requirements in the gaming industry affect both hardware and software designs on wager-based gaming devices.", "A third important difference between wager-based gaming devices and common PC based computer systems is the number and kinds of peripheral devices used on a wager-based gaming device are not as great as on PC based computer systems.", "Traditionally, in the gaming industry, wager-based gaming devices have been relatively simple in the sense that the number of peripheral devices and the number of functions the wager-based gaming device has been limited.", "Further, in operation, the functionality of wager-based gaming devices were relatively constant once the wager-based gaming device was deployed, i.e., new peripherals devices and new gaming software were infrequently added to the wager-based gaming device.", "This differs from a PC where users will go out and buy different combinations of devices and software from different manufacturers and connect them to a PC to suit their needs depending on a desired application.", "Therefore, the types of devices connected to a PC may vary greatly from user to user depending in their individual requirements and may vary significantly over time.", "Although the variety of devices available for a PC may be greater than on a wager-based gaming device, wager-based gaming devices still have unique device requirements that differ from a PC, such as device security requirements not usually addressed by PCs.", "For instance, monetary devices, such as coin dispensers, bill validators and ticket printers and computing devices that are used to govern the input and output of cash to a wager-based gaming device have security requirements that are not typically addressed in PCs.", "Therefore, many PC techniques and methods developed to facilitate device connectivity and device compatibility do not address the emphasis placed on security in the gaming industry.", "To address some of the issues described above, a number of hardware/software components and architectures are utilized in wager-based gaming devices that are not typically found in general purpose computing devices, such as PCs.", "These hardware/software components and architectures, as described below in more detail, include but are not limited to watchdog timers, voltage monitoring systems, state-based software architecture and supporting hardware, specialized communication interfaces, security monitoring and trusted memory.", "For example, a watchdog timer may be used in International Game Technology (IGT) wager-based gaming devices to provide a software failure detection mechanism In a normally operating system, the operating software periodically accesses control registers in the watchdog timer subsystem to “re-trigger” the watchdog.", "Should the operating software fail to access the control registers within a preset timeframe, the watchdog timer will timeout and generate a system reset.", "Typical watchdog timer circuits include a loadable timeout counter register to enable the operating software to set the timeout interval within a certain range of time.", "A differentiating feature of the some preferred circuits is that the operating software cannot completely disable the function of the watchdog timer.", "In other words, the watchdog timer always functions from the time power is applied to the board.", "IGT gaming computer platforms preferably use several power supply voltages to operate portions of the computer circuitry.", "These can be generated in a central power supply or locally on the computer board.", "If any of these voltages falls out of the tolerance limits of the circuitry they power, unpredictable operation of the computer may result.", "Though most modern general-purpose computers include voltage monitoring circuitry, these types of circuits only report voltage status to the operating software.", "Out of tolerance voltages can cause software malfunction, creating a potential uncontrolled condition in the gaming computer.", "Wager-based gaming devices of the present assignee typically have power supplies with tighter voltage margins than that required by the operating circuitry.", "In addition, the voltage monitoring circuitry implemented in IGT gaming computers typically has two thresholds of control.", "The first threshold generates a software event that can be detected by the operating software and an error condition generated.", "This threshold is triggered when a power supply voltage falls out of the tolerance range of the power supply, but is still within the operating range of the circuitry.", "The second threshold is set when a power supply voltage falls out of the operating tolerance of the circuitry.", "In this case, the circuitry generates a reset, halting operation of the computer.", "One standard method of operation for IGT slot device game software is to use a state device.", "Different functions of the game (bet, play, result, points in the graphical presentation, etc.)", "may be defined as a state.", "When a game moves from one state to another, critical data regarding the game software is stored in a custom non-volatile memory subsystem.", "This is critical to ensure the player's wager and credits are preserved and to minimize potential disputes in the event of a malfunction on the wager-based gaming device.", "In general, the wager-based gaming device does not advance from a first state to a second state until critical information that allows the first state to be reconstructed has been stored.", "This feature allows the game to recover operation to the current state of play in the event of a malfunction, loss of power, etc.", "that occurred just prior to the malfunction.", "In at least one embodiment, the wager-based gaming device is configured or designed to store such critical information using atomic transactions.", "Generally, an atomic operation in computer science refers to a set of operations that can be combined so that they appear to the rest of the system to be a single operation with only two possible outcomes: success or failure.", "As related to data storage, an atomic transaction may be characterized as series of database operations which either all occur, or all do not occur.", "A guarantee of atomicity prevents updates to the database occurring only partially, which can result in data corruption.", "In order to ensure the success of atomic transactions relating to critical information to be stored in the wager-based gaming device memory before a failure event (e.g., malfunction, loss of power, etc.", "), it is preferable that memory be used which includes one or more of the following criteria: direct memory access capability; data read/write capability which meets or exceeds minimum read/write access characteristics (such as, for example, at least 5.08 Mbytes/sec (Read) and/or at least 38.0 Mbytes/sec (Write)).", "Devices which meet or exceed the above criteria may be referred to as “fault-tolerant” memory devices, whereas it is which the above criteria may be referred to as “fault non-tolerant” memory devices.", "Typically, battery backed RAM devices may be configured or designed to function as fault-tolerant devices according to the above criteria, whereas flash RAM and/or disk drive memory are typically not configurable to function as fault-tolerant devices according to the above criteria.", "Accordingly, battery backed RAM devices are typically used to preserve wager-based gaming device critical data, although other types of non-volatile memory devices may be employed.", "These memory devices are typically not used in typical general-purpose computers.", "Thus, in at least one embodiment, the wager-based gaming device is configured or designed to store critical information in fault-tolerant memory (e.g., battery backed RAM devices) using atomic transactions.", "Further, in at least one embodiment, the fault-tolerant memory is able to successfully complete all desired atomic transactions (e.g., relating to the storage of wager-based gaming device critical information) within a time period of 200 milliseconds (ms) or less.", "In at least one embodiment, the time period of 200 mSec represents a maximum amount of time for which sufficient power may be available to the various wager-based gaming device components after a power outage event has occurred at the wager-based gaming device.", "As described previously, the wager-based gaming device may not advance from a first state to a second state until critical information that allows the first state to be reconstructed has been atomically stored.", "This feature allows the game to recover operation to the current state of play in the event of a malfunction, loss of power, etc.", "that occurred just prior to the malfunction.", "After the state of the wager-based gaming device is restored during the play of a wager-based game, game play may resume and the game may be completed in a manner that is no different than if the malfunction had not occurred.", "Thus, for example, when a malfunction occurs during a wager-based game, the wager-based gaming device may be restored to a state in the wager-based game just prior to when the malfunction occurred.", "The restored state may include metering information and graphical information that was displayed on the wager-based gaming device in the state prior to the malfunction.", "For example, when the malfunction occurs during the play of a card game after the cards have been dealt, the wager-based gaming device may be restored with the cards that were previously displayed as part of the card game.", "As another example, a bonus game may be triggered during the play of a wager-based game where a player is required to make a number of selections on a video display screen.", "When a malfunction has occurred after the player has made one or more selections, the wager-based gaming device may be restored to a state that shows the graphical presentation at the just prior to the malfunction including an indication of selections that have already been made by the player.", "In general, the wager-based gaming device may be restored to any state in a plurality of states that occur in the wager-based game that occurs while the wager-based game is played or to states that occur between the play of a wager-based game.", "Game history information regarding previous games played such as an amount wagered, the outcome of the game and so forth may also be stored in a non-volatile memory device.", "The information stored in the non-volatile memory may be detailed enough to reconstruct a portion of the graphical presentation that was previously presented on the wager-based gaming device and the state of the wager-based gaming device (e.g., credits) at the time the wager-based game was played.", "The game history information may be utilized in the event of a dispute.", "For example, a player may decide that in a previous wager-based game that they did not receive credit for an award that they believed they won.", "The game history information may be used to reconstruct the state of the wager-based gaming device prior, during and/or after the disputed game to demonstrate whether the player was correct or not in their assertion.", "Further details of a state based gaming system, recovery from malfunctions and game history are described in U.S. Pat.", "No.", "6,804,763, titled “High Performance Battery Backed RAM Interface”, U.S. Pat.", "No.", "6,863,608, titled “Frame Capture of Actual Game Play,” U.S. application Ser.", "No.", "10/243,104, titled, “Dynamic NV-RAM,” and U.S. application Ser.", "No.", "10/758,828, titled, “Frame Capture of Actual Game Play,” each of which is incorporated by reference and for all purposes.", "Another feature of wager-based gaming devices, such as IGT gaming computers, is that they often include unique interfaces, including serial interfaces, to connect to specific subsystems internal and external to the wager-based gaming device.", "The serial devices may have electrical interface requirements that differ from the “standard” EIA 232 serial interfaces provided by general-purpose computers.", "These interfaces may include EIA 485, EIA 422, Fiber Optic Serial, optically coupled serial interfaces, current loop style serial interfaces, etc.", "In addition, to conserve serial interfaces internally in the wager-based gaming device, serial devices may be connected in a shared, daisy-chain fashion where multiple peripheral devices are connected to a single serial channel.", "The serial interfaces may be used to transmit information using communication protocols that are unique to the gaming industry.", "For example, IGT's Netplex is a proprietary communication protocol used for serial communication between wager-based gaming devices.", "As another example, SAS is a communication protocol used to transmit information, such as metering information, from a wager-based gaming device to a remote device.", "Often SAS is used in conjunction with a player tracking system.", "IGT wager-based gaming devices may alternatively be treated as peripheral devices to a casino communication controller and connected in a shared daisy chain fashion to a single serial interface.", "In both cases, the peripheral devices are preferably assigned device addresses.", "If so, the serial controller circuitry must implement a method to generate or detect unique device addresses.", "General-purpose computer serial ports are not able to do this.", "Security monitoring circuits detect intrusion into an IGT wager-based gaming device by monitoring security switches attached to access doors in the wager-based gaming device cabinet.", "Preferably, access violations result in suspension of game play and can trigger additional security operations to preserve the current state of game play.", "These circuits also function when power is off by use of a battery backup.", "In power-off operation, these circuits continue to monitor the access doors of the wager-based gaming device.", "When power is restored, the wager-based gaming device can determine whether any security violations occurred while power was off, e.g., via software for reading status registers.", "This can trigger event log entries and further data authentication operations by the wager-based gaming device software.", "Trusted memory devices and/or trusted memory sources are preferably included in an IGT wager-based gaming device computer to ensure the authenticity of the software that may be stored on less secure memory subsystems, such as mass storage devices.", "Trusted memory devices and controlling circuitry are typically designed to not enable modification of the code and data stored in the memory device while the memory device is installed in the wager-based gaming device.", "The code and data stored in these devices may include authentication algorithms, random number generators, authentication keys, operating system kernels, etc.", "The purpose of these trusted memory devices is to provide gaming regulatory authorities a root trusted authority within the computing environment of the wager-based gaming device that can be tracked and verified as original.", "This may be accomplished via removal of the trusted memory device from the wager-based gaming device computer and verification of the secure memory device contents is a separate third party verification device.", "Once the trusted memory device is verified as authentic, and based on the approval of the verification algorithms included in the trusted device, the wager-based gaming device is enabled to verify the authenticity of additional code and data that may be located in the gaming computer assembly, such as code and data stored on hard disk drives.", "A few details related to trusted memory devices that may be used in at least one embodiment described herein are described in U.S. Pat.", "No.", "6,685,567 (U.S. patent application Ser.", "No.", "09/925,098), filed Aug. 8, 2001 and titled “Process Verification,” and U.S. Pat.", "No.", "3,221,314, filed Sep. 6, 2005, each of which is incorporated herein by reference in its entirety and for all purposes.", "In at least one embodiment, at least a portion of the trusted memory devices/sources may correspond to memory which cannot easily be altered (e.g., “unalterable memory”) such as, for example, EPROMS, PROMS, Bios, Extended Bios, and/or other memory sources which are able to be configured, verified, and/or authenticated (e.g., for authenticity) in a secure and controlled manner.", "According to a specific implementation, when a trusted information source is in communication with a remote device via a network, the remote device may employ a verification scheme to verify the identity of the trusted information source.", "For example, the trusted information source and the remote device may exchange information using public and private encryption keys to verify each other's identities.", "In another embodiment of at least one embodiment described herein, the remote device and the trusted information source may engage in methods using zero knowledge proofs to authenticate each of their respective identities.", "Details of zero knowledge proofs that may be used with the present invention are described in US publication no.", "2003/0203756, by Jackson, filed on Apr.", "25, 2002 and entitled, “Authentication in a Secure Computerized Gaming System”, which is incorporated herein in its entirety and for all purposes.", "Wager-based gaming devices storing trusted information may utilize apparatus or methods to detect and prevent tampering.", "For instance, trusted information stored in a trusted memory device may be encrypted to prevent its misuse.", "In addition, the trusted memory device may be secured behind a locked door.", "Further, one or more sensors may be coupled to the memory device to detect tampering with the memory device and provide some record of the tampering.", "In yet another example, the memory device storing trusted information might be designed to detect tampering attempts and clear or erase itself when an attempt at tampering has been detected.", "Additional details relating to trusted memory devices/sources are described in U.S. Pat.", "No.", "3,078,966, entitled “Secured Virtual Network in a Gaming Environment”, naming Nguyen et al.", "as inventors, filed on Mar.", "10, 2005, herein incorporated in its entirety and for all purposes.", "Mass storage devices used in a general purpose computer typically enable code and data to be read from and written to the mass storage device.", "In a wager-based gaming system environment, modification of the gaming code stored on a mass storage device is strictly controlled and would only be enabled under specific maintenance type events with electronic and physical enablers required.", "Though this level of security could be provided by software, IGT gaming computers that include mass storage devices preferably include hardware level mass storage data protection circuitry that operates at the circuit level to monitor attempts to modify data on the mass storage device and will generate both software and hardware error triggers should a data modification be attempted without the proper electronic and physical enablers being present.", "Details using a mass storage device that may be used with at least one embodiment described herein are described, for example, in U.S. Pat.", "No.", "6,149,522, herein incorporated by reference in its entirety for all purposes.", "FIG.", "4 shows a block diagram 400 of electronic gaming device 400, in accordance with a specific embodiment.", "Electronic gaming device 400 may include a processor 402, a memory 404, a network interface 422, input devices 428, and a display 426.Processor 402 may generate gaming options based on predetermined betting structures and/or outcome categories.", "Predetermined betting structures may utilize more than one outcome category to generate via processor 402 gaming options.", "Predetermined betting structures may combine any outcome category with any other outcome category to gaming options.", "Processor 402 may offer a gaming option which is structured so that the gaming option relates to more than one EGD.", "Processor 402 may generate contingent gaming options 108 and/or predetermined gaming options 106.Contingent gaming options 108 may be structures such that when a triggering event occurs over one or more than one gaming event, racing event, and/or sporting event, the wager is activated.", "Network interface 422 may allow electronic gaming device 400 to communicate with video/multimedia server 215, accounting/transaction server 220, gaming server 225, authentication server 230, player tracking server 235, voucher server 240, and gaming table 260.Input devices 428 may be mechanical buttons, electronic buttons, a touchscreen, a microphone, cameras, an optical scanner, or any combination thereof.", "Input devices 428 may be utilized to make a wager, to make an offer to buy or sell a voucher, to determine a voucher's worth, to cash in a voucher, to modify (e.g., change sound level, configuration, font, language, etc.)", "electronic gaming device 400, to select a movie or music, to select type of content to be displayed on main and/or auxiliary screen(s) of EGD, or any combination thereof.", "Display 426 may show video streams from one or more gaming tables 260, gaming objects from one or more gaming tables 260, computer generated graphics, predetermined gaming options 106, and/or contingent gaming options 108.Memory 404 may include various memory modules 440.Memory 404 via various memory modules 440 may include a future betting module 406, a predetermined game options module 408, a contingent game options module 410, a confirmation module 412, a validation module 414, a voucher module 416, a reporting module 418, a maintenance module 420, a player tracking preferences module 424, a searching module 430, and an account module 432.Future betting module 406 may store data relating to the predetermined betting structure.", "Processor 402 may utilize data in future betting module 406 to generate predetermined gaming options 106 and contingent gaming options 108.Any other processor (e.g., gaming server 225, any virtualized gaming server, etc.)", "may implement these functions of processor 402.Predetermined game options module 408 may store data relating to predetermined gaming options 106, which may be offered to a player.", "Contingent game options module 410 may store data relating to continent gaming options 108, which may be offered to a player.", "Confirmation module 412 may utilize data received from a voucher, the transaction history of the voucher (e.g., the voucher changed hands in a secondary market), and/or the identity of the player to confirm the value of the voucher.", "In another example, confirmation module 412 may utilize game event data, along with voucher data to confirm the value of the voucher.", "Validation module 414 may utilize data received from a voucher to confirm the validity of the voucher.", "Voucher module 416 may store data relating to generated vouchers, redeemed vouchers, bought vouchers, and/or sold vouchers.", "Reporting module 418 may generate reports related to a performance of electronic gaming device 400, electronic gaming system 200, On Demand 260, video streams, gaming objects, credit device 112, and/or identification device 114.In one implementation, reporting module 418 may reside on a central server and may aggregate and generate real time statistics on betting activities at one or more gaming device(s) at one or more participating casino's.", "The aggregate betting statistics may include trends (e.g., aggregate daily wager volume and wager amount by game types, by casinos, and the like), top games with the most payouts, top tables with the most payouts, top search structures used by players, most popular gaming device(s) by wager volume, most searched for game, gaming device(s) with least payouts, weekly trends, monthly trends, and other statistics related to game plays, wagers, people, location, and searches.", "The information and statistics generated by the server-based reporting module 418 may be displayed publicly or privately.", "For example, popular trending and statistical information on wager volume and wager amount for the top ten gaming device(s) may be publicly displayed in a casino display system so that players may study and decide what game to play, where, when, etc.", "Such a public display of general statistics may also be posted on the Internet, sent out as a text, an email, or multimedia message to the player's smart phones, tablets, desktop computer, etc.", "In another example, the trending and statistical information may also be distributed privately to privileged players such as casino club members.", "Maintenance module 420 may track any maintenance that is implemented on electronic gaming device 400 and/or electronic gaming system 200.Maintenance module 420 may schedule preventative maintenance and/or request a service call based on a device error.", "Player tracking preferences module 424 may compile and track data associated with a players preferences.", "Searching module 430 may include one or more searching structures, one or more searching algorithms, and/or any other searching mechanisms.", "The searching structures may be predetermined searching structures.", "For example, the method may start searching a first device, then a second device, then a third device, up to an Nth device based on one or more searching parameters (e.g., triggering event).", "In one example, the search may end once one or more triggering events are determined.", "In another example, the search may end once data has been received from a predetermined number (e.g., one, two, ten, one hundred, one or more) of the devices.", "In another example, the search may be based on a predetermined number of devices to be searched in combination with a predetermined number of search results to be obtained.", "In this example, the search structure may be a minimum of ten devices to be searched, along with a minimum of five gaming options to be determined.", "In another example, the searching structures may be based on one or more specific games (e.g., baccarat tables, roulette tables, blackjack tables, poker tables, craps tables, Sic Bo tables, etc.).", "Searching structure may search one or more of these games.", "In another example, the searching structure may be based on a player's preferences, past transactional history, player input, a particular gaming device or game type, a particular EGD, a particular casino, a particular location within a casino, game outcomes over a time period, payout over a time period, and/or any other criteria.", "Searching algorithms may be dynamic searching programs, which may be modified based on one or more past results, as described previously.", "In another example, the search algorithm may generate a search priority based on the probability of success various events and/or conditions, as described previously.", "In some embodiments, the search algorithm may utilize any dynamic feedback procedure to enhance current and/or future searching results.", "Account module 432 may include data relating to an account balance, a wager limit, a number of wagers placed, credit limits, any other player information, and/or any other account information.", "Data from account module 432 may be utilized to determine whether a wager may be accepted.", "For example, when a search has determined a triggering event, the device and/or system may determine whether to allow this wager based on one or more of a wager amount, a number of wagers, a wager limit, an account balance, and/or any other criteria.", "In at least one embodiment, the On Demand Module 434 may be configured or designed to implement and/or facilitate access to one or more On Demand Service(s)/feature(s) including, for example, one or more of the following (or combinations thereof): Beverage On Demand Service(s); Host On Demand Service(s); Security On Demand Service(s); Valet On Demand Service(s); Weather On Demand Service(s); Reporting service(s); and/or other aspects of On Demand Services described and/or referenced herein.", "In at least one embodiment, at least a portion of the modules discussed in block diagram 400 may reside locally in gaming terminal 400.However, in at least some embodiments, the functions performed by these modules may be implemented in one or more remote servers.", "For instance, modules 406-420, 424, 434, etc.", "may be implemented on a remote server, communicating with gaming terminal 400 via a network interface such as Ethernet in a local or a wide area network topology.", "In some implementations, these servers may be physical servers in a data center.", "In some other implementations, these servers may be virtualized.", "In yet some other implementations, the functions performed by these modules may be implemented as web services.", "For example, the predetermined game options module 408 may be implemented in software as a web service provider.", "Gaming terminal 400 would make service requests over the web for the available predetermined wager options to be displayed.", "Regardless of how the modules and their respective functions are implemented, the interoperability with the gaming terminal 400 is seamless.", "FIG.", "5 is a simplified block diagram of an exemplary intelligent multi-player electronic gaming system 500 in accordance with a specific embodiment.", "In some embodiments, gaming system by hundred may be implemented as a gaming server.", "In other embodiments, gaming system 500 may be implemented as an electronic gaming machine (EGM) or electronic gaming device (EGD).", "As illustrated in the embodiment of FIG.", "5, gaming system 500 includes at least one processor 510, at least one interface 506, and memory 516.Additionally, as illustrated in the example embodiment of FIG.", "5, gaming system 500 includes at least one master gaming controller 512, a multi-touch sensor and display system 590, a plurality of peripheral device components 550, and various other components, devices, systems such as, for example, one or more of the following (or combinations thereof): Candle control system 569 which, for example, may include functionality for determining and/or controlling the appearances of one or more candles, etc.", "; Transponders 554; Wireless communication components 556; Gaming chip/wager token tracking components 570; Games state tracking components 574; Motion/gesture analysis and interpretation components 584; Audio/video processors 583 which, for example, may include functionality for detecting, analyzing and/or managing various types of audio and/or video information relating to various activities at the gaming system.", "Various interfaces 506b (e.g., for communicating with other devices, components, systems, etc.", "); Tournament manager 575; On Demand Component(s) 576; Sensors 560; One or more cameras 562; One or more microphones 563; Secondary display(s) 535a; Input devices 530a; Motion/gesture detection components 551; Peripheral Devices 550; One or more cameras (e.g., 562) may be used to monitor, stream and/or record image content and/or video content relating to persons or objects within at least one camera's view.", "For example, in at least one embodiment where the gaming system is implemented as an EGD, camera 562 may be used to generate a live, real-time video feed of a player (or other person) who is currently interacting with the EGD.", "In some embodiments, camera 562 may be used to verify a user's identity (e.g., by authenticating detected facial features), and/or may be used to monitor or tract facial expressions and/or eye movements of a user or player who is interacting with the gaming system.", "In at least one embodiment, display system 590 may include one or more of the following (or combinations thereof): EGD controllers 591; Multipoint sensing device(s) (e.g., multi-touch surface sensors/components); Display device(s) 595; Input/touch surface 596; Etc.", "According to various embodiments, display surface(s) 595 may include one or more display screens utilizing various types of display technologies such as, for example, one or more of the following (or combinations thereof): LCDs (Liquid Crystal Display), Plasma, OLEDs (Organic Light Emitting Display), TOLED (Transparent Organic Light Emitting Display), Flexible (F)OLEDs, Active matrix (AM) OLED, Passive matrix (PM) OLED, Phosphor-escent (PH) OLEDs, SEDs (surface-conduction electron-emitter display), EPD (ElectroPhoretic display), FEDs (Field Emission Displays) and/or other suitable display technology.", "EPD displays may be provided by E-ink of Cambridge, Mass.", "OLED displays of the type list above may be provided by Universal Display Corporation, Ewing, N.J.", "In at least one embodiment, master gaming controller 512 may include one or more of the following (or combinations thereof): Authentication/validation components 544; Device drivers 542; Logic devices 513, which may include one or more processors 510; Memory 516, which may include one or more of the following (or combinations thereof): configuration software 514, non-volatile memory 515, EPROMS 508, RAM 509, associations 518 between indicia and configuration software, etc.", "; Interfaces 506; Etc.", "In at least one embodiment, Peripheral Devices 550 may include one or more of the following (or combinations thereof): Power distribution components 558; Non-volatile memory 519a (and/or other types of memory); Bill acceptor 553; Ticket I/O 555; Player tracking I/O 557; Meters 559 (e.g., hard and/or soft meters); Meter detect circuitry 559a; Processor(s) 510a; Interface(s) 506a; Display(s) 535; Independent security system 561; Door detect switches 567; Candles, etc.", "571; Input devices 530; Etc.", "In at least one embodiment, the On Demand Component(s) 576 may be configured or designed to implement and/or facilitate access to one or more On Demand Service(s)/feature(s) including, for example, one or more of the following (or combinations thereof): Beverage On Demand Service(s); Host On Demand Service(s); Security On Demand Service(s); Valet On Demand Service(s); Weather On Demand Service(s); Reporting service(s); and/or other aspects of On Demand Services described and/or referenced herein.", "In one implementation, processor 510 and master gaming controller 512 are included in a logic device 513 enclosed in a logic device housing.", "The processor 510 may include any conventional processor or logic device configured to execute software allowing various configuration and reconfiguration tasks such as, for example: a) communicating with a remote source via communication interface 506, such as a server that stores authentication information or games; b) converting signals read by an interface to a format corresponding to that used by software or memory in the gaming system; c) accessing memory to configure or reconfigure game parameters in the memory according to indicia read from the device; d) communicating with interfaces, various peripheral devices and/or I/O devices; e) operating peripheral devices such as, for example, card readers, paper ticket readers, etc.", "; f) operating various I/O devices such as, for example, displays 535, input devices 530; etc.", "For instance, the processor 510 may send messages including game play information to the displays 535 to inform players of game play/event information, wagering information, and/or other desired information.", "In at least one implementation, the gaming system may include card readers such as used with credit cards, or other identification code reading devices to allow or may require player identification in connection with play of the card game and associated recording of game action.", "Such a player identification interface may be implemented in the form of a variety of magnetic card readers commercially available for reading a player-specific identification information.", "The player-specific information may be provided on specially constructed magnetic cards issued by a casino, or magnetically coded credit cards or debit cards frequently used with national credit organizations such as VISA, MASTERCARD, AMERICAN EXPRESS, or banks and other institutions.", "The gaming system may include other types of participant identification mechanisms which may use a fingerprint image, eye blood vessel image reader, or other suitable biological information to confirm identity of the player.", "Such personalized identification information could also be used to confirm credit use of a smart card, transponder, and/or player's personal player input device (UID).", "The gaming system 500 also includes memory 516 which may include, for example, volatile memory (e.g., RAM 509), non-volatile memory 519 (e.g., disk memory, FLASH memory, EPROMs, etc.", "), unalterable memory (e.g., EPROMs 508), etc.", "The memory may be configured or designed to store, for example: 1) configuration software 514 such as one or more the parameters and settings for a game playable on the gaming system; 2) associations 518 between configuration indicia read from a device with one or more parameters and settings; 3) communication protocols allowing the processor 510 to communicate with peripheral devices and I/O devices 511; 5) a secondary memory storage device 515 such as a non-volatile memory device, configured to store gaming software related information (the gaming software related information and memory may be used to store various audio files and games not currently being used and invoked in a configuration or reconfiguration); 5) communication transport protocols (such as, for example, TCP/IP, USB, Firewire, IEEE1394, Bluetooth, IEEE 802.11x (IEEE 802.11 standards), hiperlan/2, HomeRF, etc.)", "for allowing the gaming system to communicate with local and non-local devices using such protocols; etc.", "In one implementation, the master gaming controller 512 communicates using a serial communication protocol.", "A few examples of serial communication protocols that may be used to communicate with the master gaming controller include but are not limited to USB, RS-232 and Netplex (a proprietary protocol developed by IGT, Reno, Nev.).", "A plurality of device drivers 542 may be stored in memory 516.Example of different types of device drivers may include device drivers for gaming system components, device drivers for gaming system components, etc.", "Typically, the device drivers 542 utilize a communication protocol of some type that enables communication with a particular physical device.", "The device driver abstracts the hardware implementation of a device.", "For example, a device drive may be written for at least one type of card reader that may be potentially connected to the gaming system.", "Examples of communication protocols used to implement the device drivers include Netplex, USB, Serial, Ethernet 575, Firewire, I/O debouncer, direct memory map, serial, PCI, parallel, RF, Bluetooth™, near-field communications (e.g., using near-field magnetics), 802.11 (WiFi), etc.", "Netplex is a proprietary IGT standard while the others are open standards.", "According to a specific embodiment, when one type of a particular device is exchanged for another type of the particular device, a new device driver may be loaded from the memory 516 by the processor 510 to allow communication with the device.", "For instance, one type of card reader in gaming system 500 may be replaced with a second type of card reader where device drivers for both card readers are stored in the memory 516.In some embodiments, the software units stored in the memory 516 may be upgraded as needed.", "For instance, when the memory 516 is a hard drive, new games, game options, various new parameters, new settings for existing parameters, new settings for new parameters, device drivers, and new communication protocols may be uploaded to the memory from the master gaming controller 512 or from some other external device.", "As another example, when the memory 516 includes a CD/DVD drive including a CD/DVD designed or configured to store game options, parameters, and settings, the software stored in the memory may be upgraded by replacing a first CD/DVD with a second CD/DVD.", "In yet another example, when the memory 516 uses one or more flash memory 519 or EPROM 508 units designed or configured to store games, game options, parameters, settings, the software stored in the flash and/or EPROM memory units may be upgraded by replacing one or more memory units with new memory units which include the upgraded software.", "In another embodiment, one or more of the memory devices, such as the hard-drive, may be employed in a game software download process from a remote software server.", "In some embodiments, the gaming system 500 may also include various authentication and/or validation components 544 which may be used for authenticating/validating specified gaming system components such as, for example, hardware components, software components, firmware components, information stored in the gaming system memory 516, etc.", "Examples of various authentication and/or validation components are described in U.S. Pat.", "No.", "6,620,047, entitled, “ELECTRONIC GAMING APPARATUS HAVING AUTHENTICATION DATA SETS,” incorporated herein by reference in its entirety for one or more purposes.", "Sensors 560 may include, for example, optical sensors, pressure sensors, RF sensors, Infrared sensors, motion sensors, audio sensors, image sensors, thermal sensors, biometric sensors, etc.", "As mentioned previously, such sensors may be used for a variety of functions such as, for example: detecting the presence and/or monetary amount of gaming chips which have been placed within a player's wagering zone; detecting (e.g., in real time) the presence and/or monetary amount of gaming chips which are within the player's personal space; etc.", "In one implementation, at least a portion of the sensors 560 and/or input devices 530 may be implemented in the form of touch keys selected from a wide variety of commercially available touch keys used to provide electrical control signals.", "Alternatively, some of the touch keys may be implemented in another form which are touch sensors such as those provided by a touchscreen display.", "For example, in at least one implementation, the gaming system player may include input functionality for enabling players to provide their game play decisions/instructions (and/or other input) to the EGD using the touch keys and/or other player control sensors/buttons.", "Additionally, such input functionality may also be used for allowing players to provide input to other devices in the casino gaming network (such as, for example, player tracking systems, side wagering systems, etc.)", "Wireless communication components 556 may include one or more communication interfaces having different architectures and utilizing a variety of protocols such as, for example, 802.11 (WiFi), 802.15 (including Bluetooth™), 802.16 (WiMax), 802.22, Cellular standards such as CDMA, CDMA2000, WCDMA, Radio Frequency (e.g., RFID), Infrared, Near Field Magnetic communication protocols, etc.", "The communication links may transmit electrical, electromagnetic or optical signals which carry digital data streams or analog signals representing various types of information.", "An example of a near-field communication protocol is the ECMA-340 “Near Field Communication—Interface and Protocol (NFCIP-1)”, published by ECMA International (www.ecma-international.org), herein incorporated by reference in its entirety for one or more purposes.", "It may be appreciated that other types of Near Field Communication protocols may be used including, for example, near field magnetic communication protocols, near field RF communication protocols, and/or other wireless protocols which provide the ability to control with relative precision (e.g., on the order of centimeters, inches, feet, meters, etc.)", "the allowable radius of communication between at least 5 devices using such wireless communication protocols.", "Power distribution components 558 may include, for example, components or devices which are operable for providing wireless power to other devices.", "For example, in one implementation, the power distribution components 558 may include a magnetic induction system which is adapted to provide wireless power to one or more portable UIDs at the gaming system.", "In one implementation, a UID docking region may include a power distribution component which is able to recharge a UID placed within the UID docking region without requiring metal-to-metal contact.", "In at least one embodiment, motion/gesture detection component(s) 551 may be configured or designed to detect player movements and/or gestures and/or other input data from the player.", "In some embodiments, at least one gaming system may have its own respective motion/gesture detection component(s).", "In other embodiments, motion/gesture detection component(s) 551 may be implemented as a separate sub-system of the gaming system which is not associated with any one specific gaming system or device.", "FIG.", "6 is a simplified block diagram of an exemplary mobile gaming device 600 in accordance with a specific embodiment.", "In at least one embodiment, one or more players may participate in a wager-based, arcade-style video game session using mobile gaming devices.", "In at least some embodiments, the mobile gaming device may be configured or designed to include or provide functionality which is similar to that of an electronic gaming device (EGD) such as that described, for example, in FIG.", "4.As illustrated in the example of FIG.", "6, mobile gaming device 600 may include a variety of components, modules and/or systems for providing various functionality.", "For example, as illustrated in FIG.", "6, mobile gaming device 600 may include Mobile Device Application components (e.g., 660), which, for example, may include, but are not limited to, one or more of the following (or combinations thereof): UI Components 662 such as those illustrated, described, and/or referenced herein.", "Database Components 664 such as those illustrated, described, and/or referenced herein.", "Processing Components 666 such as those illustrated, described, and/or referenced herein.", "On Demand Application(s) 676 such as those illustrated, described, and/or referenced herein.", "Other Components 668 which, for example, may include components for facilitating and/or enabling the mobile gaming device to perform and/or initiate various types of operations, activities, functions such as those described herein.", "In at least one embodiment, the mobile gaming device may include Mobile Device App Component(s) which have been configured or designed to provide functionality for enabling or implementing at least a portion of the various On Demand Service(s) at the mobile gaming device.", "According to specific embodiments, various aspects, features, and/or functionalities of the mobile gaming device may be performed, implemented and/or initiated by one or more of the following types of systems, components, systems, devices, procedures, processes, etc.", "(or combinations thereof): Processor(s) 610 Device Drivers 642 Memory 616 Interface(s) 606 Power Source(s)/Distribution 643 Geolocation module 646 Display(s) 635 I/O Devices 630 Audio/Video devices(s) 639 Peripheral Devices 631 Motion Detection module 640 User Identification/Authentication module 647 Client App Component(s) 660 Other Component(s) 668 UI Component(s) 662 Database Component(s) 664 Processing Component(s) 666 Software/Hardware Authentication/Validation 644 Wireless communication module(s) 645 Information Filtering module(s) 649 Operating mode selection component 648 Speech Processing module 654 Scanner/Camera 652 OCR Processing Engine 656 etc.", "FIG.", "7 illustrates an example embodiment of a system server 780 which may be used for implementing various aspects/features described herein.", "In at least one embodiment, the system server 780 includes at least one network device 760, and at least one storage device 770 (such as, for example, a direct attached storage device).", "In one embodiment, system server 780 may be suitable for implementing at least some of the On Demand Service(s)/feature(s) described herein.", "In according to one embodiment, network device 760 may include a master central processing unit (CPU) 762, interfaces 768, and a bus 767 (e.g., a PCI bus).", "When acting under the control of appropriate software or firmware, the CPU 762 may be responsible for implementing specific functions associated with the functions of a desired network device.", "For example, when configured as a server, the CPU 762 may be responsible for analyzing packets; encapsulating packets; forwarding packets to appropriate network devices; instantiating various types of virtual machines, virtual interfaces, virtual storage volumes, virtual appliances; etc.", "The CPU 762 preferably accomplishes at least a portion of these functions under the control of software including an operating system (e.g.", "Linux), and any appropriate system software (such as, for example, AppLogic™™ software).", "CPU 762 may include one or more processors 763 such as, for example, one or more processors from the AMD, Motorola, Intel and/or MIPS families of microprocessors.", "In an alternative embodiment, processor 763 may be specially designed hardware for controlling the operations of system server 780.In a specific embodiment, a memory 761 (such as non-volatile RAM and/or ROM) also forms part of CPU 762.However, there may be many different ways in which memory could be coupled to the system.", "Memory block 761 may be used for a variety of purposes such as, for example, caching and/or storing data, programming instructions, etc.", "The interfaces 768 may be typically provided as interface cards (sometimes referred to as “line cards”).", "Alternatively, one or more of the interfaces 768 may be provided as on-board interface controllers built into the system motherboard.", "Generally, they control the sending and receiving of data packets over the network and sometimes support other peripherals used with the system server 780.Among the interfaces that may be provided may be FC interfaces, Ethernet interfaces, frame relay interfaces, cable interfaces, DSL interfaces, token ring interfaces, Infiniband interfaces, and the like.", "In addition, various very high-speed interfaces may be provided, such as fast Ethernet interfaces, Gigabit Ethernet interfaces, ATM interfaces, HSSI interfaces, POS interfaces, FDDI interfaces, ASI interfaces, DHEI interfaces and the like.", "Other interfaces may include one or more wireless interfaces such as, for example, 802.11 (WiFi) interfaces, 802.15 interfaces (including Bluetooth™), 802.16 (WiMax) interfaces, 802.22 interfaces, Cellular standards such as CDMA interfaces, CDMA2000 interfaces, WCDMA interfaces, TDMA interfaces, Cellular 3G interfaces, etc.", "Generally, one or more interfaces may include ports appropriate for communication with the appropriate media.", "In some cases, they may also include an independent processor and, in some instances, volatile RAM.", "The independent processors may control such communications intensive tasks as packet switching, media control and management.", "By providing separate processors for the communications intensive tasks, these interfaces allow the master microprocessor 762 to efficiently perform routing computations, network diagnostics, security functions, etc.", "In at least one embodiment, some interfaces may be configured or designed to allow the system server 780 to communicate with other network devices associated with various local area network (LANs) and/or wide area networks (WANs).", "Other interfaces may be configured or designed to allow network device 760 to communicate with one or more direct attached storage device(s) 770.Although the system shown in FIG.", "7 illustrates one specific network device described herein, it is by no means the only network device architecture on which one or more embodiments may be implemented.", "For example, an architecture having a single processor that handles communications as well as routing computations, etc.", "may be used.", "Further, other types of interfaces and media could also be used with the network device.", "Regardless of network device's configuration, it may employ one or more memories or memory modules (such as, for example, memory block 765, which, for example, may include random access memory (RAM)) configured to store data, program instructions for the general-purpose network operations and/or other information relating to the functionality of the various On Demand Service(s)/feature(s) described herein.", "The program instructions may control the operation of an operating system and/or one or more applications, for example.", "The memory or memories may also be configured to store data structures, and/or other specific non-program information described herein.", "Because such information and program instructions may be employed to implement the systems/methods described herein, one or more embodiments relates to machine readable media that include program instructions, state information, etc.", "for performing various operations described herein.", "Examples of machine-readable storage media include, but are not limited to, magnetic media such as hard disks, floppy disks, and magnetic tape; optical media such as CD-ROM disks; magneto-optical media such as floptical disks; and hardware devices that may be specially configured to store and perform program instructions, such as read-only memory devices (ROM) and random access memory (RAM).", "Some embodiments may also be embodied in transmission media such as, for example, a carrier wave travelling over an appropriate medium such as airwaves, optical lines, electric lines, etc.", "Examples of program instructions include both machine code, such as produced by a compiler, and files containing higher level code that may be executed by the computer using an interpreter.", "FIG.", "8 illustrates an example of a functional block diagram of a Gaming System Server in accordance with a specific embodiment.", "In at least one embodiment, the Virtual Live electronic gaming device System Server may be operable to perform and/or implement various types of functions, operations, actions, and/or other features, such as, for example, one or more of those described and/or referenced herein.", "In at least one embodiment, the Gaming System Server may include a plurality of components operable to perform and/or implement various types of functions, operations, actions, and/or other features such as, for example, one or more of the following (or combinations thereof): Context Interpreter (e.g., 802) which, for example, may be operable to automatically and/or dynamically analyze contextual criteria relating to a detected set of event(s) and/or condition(s), and automatically determine or identify one or more contextually appropriate response(s) based on the contextual interpretation of the detected event(s)/condition(s).", "According to different embodiments, examples of contextual criteria which may be analyzed may include, but are not limited to, one or more of the following (or combinations thereof): location-based criteria (e.g., geolocation of mobile gaming device, geolocation of EGD, etc.)", "time-based criteria identity of user(s) user profile information transaction history information recent user activities etc.", "Time Synchronization Engine (e.g., 804) which, for example, may be operable to manages universal time synchronization (e.g., via NTP and/or GPS) Search Engine (e.g., 828) which, for example, may be operable to search for transactions, logs, game history information, player information, On Demand information, etc., which may be accessed from one or more local and/or remote databases.", "Configuration Engine (e.g., 832) which, for example, may be operable to determine and handle configuration of various customized configuration parameters for one or more devices, component(s), system(s), process(es), etc.", "Time Interpreter (e.g., 818) which, for example, may be operable to automatically and/or dynamically modify or change identifier activation and expiration time(s) based on various criteria such as, for example, time, location, transaction status, etc.", "Authentication/Validation Component(s) (e.g., 847) (password, software/hardware info, SSL certificates) which, for example, may be operable to perform various types of authentication/validation tasks such as one or more of those described and/or referenced herein.", "Transaction Processing Engine (e.g., 822) which, for example, may be operable to handle various types of transaction processing tasks such as, for example, one or more of those described and/or referenced herein.", "OCR Processing Engine (e.g., 834) which, for example, may be operable to perform image processing and optical character recognition of images such as those captured by a gaming device camera, for example.", "Database Manager (e.g., 826) which, for example, may be operable to handle various types of tasks relating to database updating, database management, database access, etc.", "In at least one embodiment, the Database Manager may be operable to manage game history databases, player tracking databases, etc.", "Log Component(s) (e.g., 810) which, for example, may be operable to generate and manage transactions history logs, system errors, connections from APIs, etc.", "Status Tracking Component(s) (e.g., 812) which, for example, may be operable to automatically and/or dynamically determine, assign, and/or report updated transaction status information based, for example, on the state of the transaction.", "Gateway Component(s) (e.g., 814) which, for example, may be operable to facilitate and manage communications and transactions with external Payment Gateways.", "Web Interface Component(s) (e.g., 808) which, for example, may be operable to facilitate and manage communications and transactions with virtual live electronic gaming device web portal(s).", "API Interface(s) to Gaming System Server(s) (e.g., 846) which, for example, may be operable to facilitate and manage communications and transactions with API Interface(s) to Gaming System Server(s) API Interface(s) to 3rd Party System Server(s) (e.g., 848) which, for example, may be operable to facilitate and manage communications and transactions with API Interface(s) to 3rd Party System Server(s) At least one processor 810.In at least one embodiment, the processor(s) 810 may include one or more commonly known CPUs which are deployed in many of today's consumer electronic devices, such as, for example, CPUs or processors from the Motorola or Intel family of microprocessors, etc.", "In an alternative embodiment, at least one processor may be specially designed hardware for controlling the operations of a gaming system.", "In a specific embodiment, a memory (such as non-volatile RAM and/or ROM) also forms part of CPU.", "When acting under the control of appropriate software or firmware, the CPU may be responsible for implementing specific functions associated with the functions of a desired network device.", "The CPU preferably accomplishes one or more these functions under the control of software including an operating system, and any appropriate applications software.", "Memory 816, which, for example, may include volatile memory (e.g., RAM), non-volatile memory (e.g., disk memory, FLASH memory, EPROMs, etc.", "), unalterable memory, and/or other types of memory.", "In at least one implementation, the memory 816 may include functionality similar to at least a portion of functionality implemented by one or more commonly known memory devices such as those described herein and/or generally known to one having ordinary skill in the art.", "According to different embodiments, one or more memories or memory modules (e.g., memory blocks) may be configured or designed to store data, program instructions for the functional operations of the mobile gaming system and/or other information relating to the functionality of the various Mobile Transaction techniques described herein.", "The program instructions may control the operation of an operating system and/or one or more applications, for example.", "The memory or memories may also be configured to store data structures, metadata, identifier information/images, and/or information/data relating to other features/functions described herein.", "Interface(s) 806 which, for example, may include wired interfaces and/or wireless interfaces.", "In at least one implementation, the interface(s) 806 may include functionality similar to at least a portion of functionality implemented by one or more computer system interfaces such as those described herein and/or generally known to one having ordinary skill in the art.", "Device driver(s) 842.In at least one implementation, the device driver(s) 842 may include functionality similar to at least a portion of functionality implemented by one or more computer system driver devices such as those described herein and/or generally known to one having ordinary skill in the art.", "One or more display(s) 835.Messaging Server Component(s) 836, which, for example, may be configured or designed to provide various functions and operations relating to messaging activities and communications.", "Network Server Component(s) 837, which, for example, may be configured or designed to provide various functions and operations relating to network server activities and communications.", "On Demand Services System Components (Backend) 876.In at least one embodiment, the Backend On Demand Services System Components may include the ODS Menu Management System, and may be configured or designed to implement and/or facilitate implementation, configuration, management, analysis, and reporting of On Demand Services including, for example, one or more of the following (or combinations thereof): Beverage On Demand Service(s); Host On Demand Service(s); Security On Demand Service(s); Valet On Demand Service(s); Weather On Demand Service(s); Reporting service(s); and/or other aspects of On Demand Services described and/or referenced herein.", "Etc.", "FIG.", "9 shows a block diagram illustrating components of a gaming system 900 which may be used for implementing various aspects of example embodiments.", "In FIG.", "9, the components of a gaming system 900 for providing game software licensing and downloads are described functionally.", "The described functions may be instantiated in hardware, firmware and/or software and executed on a suitable device.", "In the system 900, there may be many instances of the same function, such as multiple game play interfaces 911.Nevertheless, in FIG.", "9, only one instance of at least one function is shown.", "The functions of the components may be combined.", "For example, a single device may comprise the game play interface 911 and include trusted memory devices or sources 909.The gaming system 900 may receive inputs from different groups/entities and output various services and or information to these groups/entities.", "For example, game players 925 primarily input cash or indicia of credit into the system, make game selections that trigger software downloads, and receive entertainment in exchange for their inputs.", "Game software content providers provide game software for the system and may receive compensation for the content they provide based on licensing agreements with the gaming machine operators.", "Gaming machine operators select game software for distribution, distribute the game software on the gaming devices in the system 900, receive revenue for the use of their software and compensate the gaming machine operators.", "The gaming regulators 930 may provide rules and regulations that may be applied to the gaming system and may receive reports and other information confirming that rules are being obeyed.", "In the following paragraphs, details of at least one component and some of the interactions between the components are described with respect to FIG.", "9.The game software license host 901 may be a server connected to a number of remote gaming devices that provides licensing services to the remote gaming devices.", "For example, in other embodiments, the license host 901 may 1) receive token requests for tokens used to activate software executed on the remote gaming devices, 9) send tokens to the remote gaming devices, 3) track token usage and 4) grant and/or renew software licenses for software executed on the remote gaming devices.", "The token usage may be used in utility based licensing schemes, such as a pay-per-use scheme.", "In another embodiment, a game usage-tracking host 915 may track the usage of game software on a plurality of devices in communication with the host.", "The game usage-tracking host 915 may be in communication with a plurality of game play hosts and gaming machines.", "From the game play hosts and gaming machines, the game usage tracking host 915 may receive updates of an amount that at least one game available for play on the devices has been played and on amount that has been wagered per game.", "This information may be stored in a database and used for billing according to methods described in a utility based licensing agreement.", "The game software host 902 may provide game software downloads, such as downloads of game software or game firmware, to various devious in the game system 900.For example, when the software to generate the game is not available on the game play interface 911, the game software host 902 may download software to generate a selected game of chance played on the game play interface.", "Further, the game software host 902 may download new game content to a plurality of gaming machines via a request from a gaming machine operator.", "In one embodiment, the game software host 902 may also be a game software configuration-tracking host 913.The function of the game software configuration-tracking host is to keep records of software configurations and/or hardware configurations for a plurality of devices in communication with the host (e.g., denominations, number of paylines, paytables, max/min wagers).", "Details of a game software host and a game software configuration host that may be used with example embodiments are described in co-pending U.S. Pat.", "No.", "6,645,077, by Rowe, titled, “Gaming Terminal Data Repository and Information System,” filed Dec. 21, 2000, which is incorporated herein in its entirety and for one or more purposes.", "A game play host device 903 may be a host server connected to a plurality of remote clients that generates games of chance that are displayed on a plurality of remote game play interfaces 911.For example, the game play host device 903 may be a server that provides central determination for a bingo game play played on a plurality of connected game play interfaces 911.As another example, the game play host device 903 may generate games of chance, such as slot games or video card games, for display on a remote client.", "A game player using the remote client may be able to select from a number of games that are provided on the client by the host device 903.The game play host device 903 may receive game software management services, such as receiving downloads of new game software, from the game software host 902 and may receive game software licensing services, such as the granting or renewing of software licenses for software executed on the device 903, from the game license host 901.In particular embodiments, the game play interfaces or other gaming devices in the gaming system 900 may be portable devices, such as electronic tokens, cell phones, smart cards, tablet PC's and PDA's.", "The portable devices may support wireless communications and thus, may be referred to as wireless mobile devices.", "The network hardware architecture 916 may be enabled to support communications between wireless mobile devices and other gaming devices in gaming system.", "In one embodiment, the wireless mobile devices may be used to play games of chance.", "The gaming system 900 may use a number of trusted information sources.", "Trusted information sources 904 may be devices, such as servers, that provide information used to authenticate/activate other pieces of information.", "CRC values used to authenticate software, license tokens used to allow the use of software or product activation codes used to activate to software are examples of trusted information that might be provided from a trusted information source 904.Trusted information sources may be a memory device, such as an EPROM, that includes trusted information used to authenticate other information.", "For example, a game play interface 911 may store a private encryption key in a trusted memory device that is used in a private key-public key encryption scheme to authenticate information from another gaming device.", "When a trusted information source 904 is in communication with a remote device via a network, the remote device may employ a verification scheme to verify the identity of the trusted information source.", "For example, the trusted information source and the remote device may exchange information using public and private encryption keys to verify at least one other's identities.", "In another example of an embodiment, the remote device and the trusted information source may engage in methods using zero knowledge proofs to authenticate at least one of their respective identities.", "Details of zero knowledge proofs that may be used with example embodiments are described in US publication no.", "9003/0203756, by Jackson, filed on Apr.", "25, 2002 and titled, “Authentication in a Secure Computerized Gaming System, which is incorporated herein in its entirety and for one or more purposes.", "Gaming devices storing trusted information might utilize apparatus or methods to detect and prevent tampering.", "For instance, trusted information stored in a trusted memory device may be encrypted to prevent its misuse.", "In addition, the trusted memory device may be secured behind a locked door.", "Further, one or more sensors may be coupled to the memory device to detect tampering with the memory device and provide some record of the tampering.", "In yet another example, the memory device storing trusted information might be designed to detect tampering attempts and clear or erase itself when an attempt at tampering has been detected.", "The gaming system 900 of example embodiments may include devices 906 that provide authorization to download software from a first device to a second device and devices 907 that provide activation codes or information that allow downloaded software to be activated.", "The devices, 906 and 907, may be remote servers and may also be trusted information sources.", "One example of a method of providing product activation codes that may be used with example embodiments is describes in previously incorporated U.S. Pat.", "No.", "6,264,561.A device 906 that monitors a plurality of gaming devices to determine adherence of the devices to gaming jurisdictional rules 908 may be included in the system 900.In one embodiment, a gaming jurisdictional rule server may scan software and the configurations of the software on a number of gaming devices in communication with the gaming rule server to determine whether the software on the gaming devices is valid for use in the gaming jurisdiction where the gaming device is located.", "For example, the gaming rule server may request a digital signature, such as CRC's, of particular software components and compare them with an approved digital signature value stored on the gaming jurisdictional rule server.", "Further, the gaming jurisdictional rule server may scan the remote gaming device to determine whether the software is configured in a manner that is acceptable to the gaming jurisdiction where the gaming device is located.", "For example, a maximum wager limit may vary from jurisdiction to jurisdiction and the rule enforcement server may scan a gaming device to determine its current software configuration and its location and then compare the configuration on the gaming device with approved parameters for its location.", "A gaming jurisdiction may include rules that describe how game software may be downloaded and licensed.", "The gaming jurisdictional rule server may scan download transaction records and licensing records on a gaming device to determine whether the download and licensing was carried out in a manner that is acceptable to the gaming jurisdiction in which the gaming device is located.", "In general, the game jurisdictional rule server may be utilized to confirm compliance to any gaming rules passed by a gaming jurisdiction when the information needed to determine rule compliance is remotely accessible to the server.", "Game software, firmware or hardware residing a particular gaming device may also be used to check for compliance with local gaming jurisdictional rules.", "In one embodiment, when a gaming device is installed in a particular gaming jurisdiction, a software program including jurisdiction rule information may be downloaded to a secure memory location on a gaming machine or the jurisdiction rule information may be downloaded as data and utilized by a program on the gaming machine.", "The software program and/or jurisdiction rule information may check the gaming device software and software configurations for compliance with local gaming jurisdictional rules.", "In another embodiment, the software program for ensuring compliance and jurisdictional information may be installed in the gaming machine prior to its shipping, such as at the factory where the gaming machine is manufactured.", "The gaming devices in game system 900 may utilize trusted software and/or trusted firmware.", "Trusted firmware/software is trusted in the sense that is used with the assumption that it has not been tampered with.", "For instance, trusted software/firmware may be used to authenticate other game software or processes executing on a gaming device.", "As an example, trusted encryption programs and authentication programs may be stored on an EPROM on the gaming machine or encoded into a specialized encryption chip.", "As another example, trusted game software, e.g., game software approved for use on gaming devices by a local gaming jurisdiction may be required on gaming devices on the gaming machine.", "In example embodiments, the devices may be connected by a network 916 with different types of hardware using different hardware architectures.", "Game software may be quite large and frequent downloads may place a significant burden on a network, which may slow information transfer speeds on the network.", "For game-on-demand services that may require frequent downloads of game software in a network, efficient downloading is desirable for the service to viable.", "Thus, in example embodiments, network efficient devices 910 may be used to actively monitor and maintain network efficiency.", "For instance, software locators may be used to locate nearby locations of game software for peer-to-peer transfers of game software.", "In another example, network traffic may be monitored and downloads may be actively rerouted to maintain network efficiency.", "One or more devices in example embodiments may provide game software and game licensing related auditing, billing and reconciliation reports to server 912.For example, a software licensing billing server may generate a bill for a gaming device operator based upon a usage of games over a time period on the gaming devices owned by the operator.", "In another example, a software auditing server may provide reports on game software downloads to various gaming devices in the gaming system 900 and current configurations of the game software on these gaming devices.", "At particular time intervals, the software auditing server 912 may also request software configurations from a number of gaming devices in the gaming system.", "The server may then reconcile the software configuration on at least one gaming device.", "In one embodiment, the software auditing server 912 may store a record of software configurations on at least one gaming device at particular times and a record of software download transactions that have occurred on the device.", "By applying at least one of the recorded game software download transactions since a selected time to the software configuration recorded at the selected time, a software configuration is obtained.", "The software auditing server may compare the software configuration derived from applying these transactions on a gaming device with a current software configuration obtained from the gaming device.", "After the comparison, the software-auditing server may generate a reconciliation report that confirms that the download transaction records are compriseent with the current software configuration on the device.", "The report may also identify any incompriseencies.", "In another embodiment, both the gaming device and the software auditing server may store a record of the download transactions that have occurred on the gaming device and the software auditing server may reconcile these records.", "There are many possible interactions between the components described with respect to FIG.", "9.Many of the interactions are coupled.", "For example, methods used for game licensing may affect methods used for game downloading and vice versa.", "For the purposes of explanation, details of a few possible interactions between the components of the system 900 relating to software licensing and software downloads have been described.", "The descriptions are selected to illustrate particular interactions in the game system 900.These descriptions are provided for the purposes of explanation only and are not intended to limit the scope of example embodiments described herein.", "Example Procedures and Flow Diagrams According to different embodiments, at least a portion of the various types of functions, operations, actions, and/or other features provided by the On Demand Procedures described herein may be implemented at one or more client systems(s), at one or more System Servers(s), and/or combinations thereof.", "In at least one embodiment, one or more of the On Demand procedures may be operable to utilize and/or generate various different types of data and/or other types of information when performing specific tasks and/or operations.", "This may include, for example, input data/information and/or output data/information.", "For example, in at least one embodiment, the On Demand procedures may be operable to access, process, and/or otherwise utilize information from one or more different types of sources, such as, for example, one or more local and/or remote memories, devices and/or systems.", "Additionally, in at least one embodiment, the On Demand procedures may be operable to generate one or more different types of output data/information, which, for example, may be stored in memory of one or more local and/or remote devices and/or systems.", "Examples of different types of input data/information and/or output data/information which may be accessed and/or utilized by the On Demand procedures may include, but are not limited to, one or more of those described and/or referenced herein.", "In at least one embodiment, a given instance of the On Demand procedures may access and/or utilize information from one or more associated databases.", "In at least one embodiment, at least a portion of the database information may be accessed via communication with one or more local and/or remote memory devices.", "Examples of different types of data which may be accessed by the On Demand procedures may include, but are not limited to, one or more of those described and/or referenced herein.", "According to specific embodiments, multiple instances or threads of the On Demand procedures may be concurrently implemented and/or initiated via the use of one or more processors and/or other combinations of hardware and/or hardware and software.", "For example, in at least some embodiments, various aspects, features, and/or functionalities of the On Demand procedures may be performed, implemented and/or initiated by one or more of the various systems, components, systems, devices, procedures, processes, etc., described and/or referenced herein.", "According to different embodiments, one or more different threads or instances of the On Demand procedures may be initiated in response to detection of one or more conditions or events satisfying one or more different types of minimum threshold criteria for triggering initiation of at least one instance of the On Demand procedures.", "Various examples of conditions or events which may trigger initiation and/or implementation of one or more different threads or instances of the On Demand procedures may include, but are not limited to, one or more of those described and/or referenced herein.", "According to different embodiments, one or more different threads or instances of the On Demand procedures may be initiated and/or implemented manually, automatically, statically, dynamically, concurrently, and/or combinations thereof.", "Additionally, different instances and/or embodiments of the On Demand procedures may be initiated at one or more different time intervals (e.g., during a specific time interval, at regular periodic intervals, at irregular periodic intervals, upon demand, etc.).", "In at least one embodiment, initial configuration of a given instance of the On Demand procedures may be performed using one or more different types of initialization parameters.", "In at least one embodiment, at least a portion of the initialization parameters may be accessed via communication with one or more local and/or remote memory devices.", "In at least one embodiment, at least a portion of the initialization parameters provided to an instance of the On Demand procedures may correspond to and/or may be derived from the input data/information.", "Although several example embodiments of one or more aspects and/or features have been described in detail herein with reference to the accompanying drawings, it is to be understood that aspects and/or features are not limited to these precise embodiments, and that various changes and modifications may be effected therein by one skilled in the art without departing from the scope of spirit of the On Demand Services System(s) as defined, for example, in the appended claims." ] ]
Patent_15876097
[ [ "METHODS OF TREATMENT OF, AND FORMULATIONS FOR TREATMENT OF ANORECTAL AND GENITOURINARY CONDITIONS", "This invention relates to a novel method of treating various inflammation-related anorectal and genitourinary conditions using various related, novel formulations.", "The formulations comprise, at a minimum, a corticosteroid, an antidepressant agent(s) with anti-allergic and/or anti-itch properties and a cooling/soothing agent(s).", "Selection of specific ingredients depends on the nature of the target tissues, the etiologies of inflammation and the severity of symptoms.", "To maximize its efficacy, each of the formulations has a unique combination of several active ingredients, and each of these ingredients exerts its anti-inflammatory effect at various phases of the inflammatory cascade, resulting in a synergistic effect of pain relief and healing.", "To minimize the side effects, the current multi-active ingredient formulations allow each of these ingredients to exist at a lower concentration than the existing single-active ingredient formulations, thus minimizing the likelihood for side effects due to systemic absorption and toxicity.", "The formulations are highly versatile in that the composition of the ingredients can be varied and adjusted to treat a wide array of anorectal and genitourinary conditions." ], [ "1.A topically-administered composition for treating inflammation-related medical conditions, the composition consisting of active ingredients and inactive ingredients, the active ingredients consisting of: (a) a corticosteroid ingredient, or salt thereof, selected from the group consisting of alclometasone dipropionate, amcinonide, beclomethasone, betamethasone benzoate, betamethasone dipropionate, betamethasone propionate, betamethasone valerate, budesonide, clobetasol propionate, clobetasone butyrate, clocortolone pivolate, cortisone, desonide, desoximetasone, dexamethasone, diflorasone diacetate, flumethasone pivolate, flunisolide, fluocinolone acetonide, fluocinonide, flurandrenolide, fluticasone propionate, halobetasol propionate, halocinonide, hydrocortisone, hydrocortisone acetate, hydrocortisone butyrate, hydrocortisone probutate, hydrocortisone propionate, hydrocortisone valerate, methylprednisolone, mometasone furoate, prednicarbate, prednisolone, prednisone acetate, prednisone valerate, triamcinolone acetonide, and triamcinolone hexacetonide; (b) an anti-depressant agent(s) ingredient, or salt thereof, selected from the group consisting of agomelatine, amitryptiline, amoxapine, bupropion, buspirone, carbamazepine, citalopram, clomipramine, desipramine, desvenlafaxine, dexmethylphenidate, dextromethorphan, dosulepin, doxepin, duloxetine, escitalopram, fluoxetine, fluvoxamine, imipramine, isocarboxazid, lamotrigine, lisdexamfetamine, lofepramine, maprotiline, methylphenidate, mianserin, milnacipran, mirtazapine, moclobemide, nefazodone, nortriptyline, opipramol, paroxetine, phenelzine, pirlindole, protriptyline, reboxetine, selegiline, sertraline, sibutramine, tandospirone, tianeptine, tramadol, tranylcypromine, trazodone, trimipramine, valproic acid, venlafaxine, and viloxazine; (c) a cooling/soothing agent(s) ingredient(s), or salt(s) or oil(s) thereof, selected from the group consisting of camphor, camphor oil, cinnamon oil, citronella oil, cornmint oil, eucalyptus oil, menthol, methyl salicylate, and peppermint oil, and combinations thereof; wherein said corticosteroid agent(s) is present in an amount of from about 0.0005% to about 10% by weight, said anti-depressant agent(s) is present in an amount of from about 0.005% to about 20% by weight, and said cooling/soothing agent(s) are present in an amount of from about 0.001% to about 15% by weight; and wherein the inactive ingredients consist of a commercially accessible cream base.", "2.The composition according to claim 1 wherein said corticosteroid agent(s) is a low-mid to mid-potency corticosteroid, or salt thereof, selected from the group consisting of alclometasone dipropionate, clobetasone butyrate, clocortolone pivolate, cortisone, desoximetasone, dexamethasone, hydrocortisone, hydrocortisone acetate, hydrocortisone butyrate, hydrocortisone propionate, hydrocortisone probutate, hydrocortisone valerate, methylprednisolone, prednisolone, prednisone acetate, prednisone valerate, triamcinolone acetonide, and triamcinolone hexacetonide.", "3.The composition according to claim 1 wherein said corticosteroid is a mid- to high-potency corticosteroid, or salt thereof, selected from the group consisting of amcinonide, beclomethasone, betamethasone benzoate, betamethasone dipropionate, betamethasone propionate, betamethasone valerate, budesonide, clobetasol propionate, desonide, diflorasone diacetate, flumethasone pivolate, flunisolide, fluocinolone acetonide, fluocinonide, flurandrenolide, fluticasone propionate, halobetasol propionate, halocinonide, mometasone furoate, and prednicarbate.", "4.A method of treatment of inflammation-related anorectal medical conditions by delivering a composition according to claim 1, 2 or 3 comprising the steps of: (a) diagnosing one or more of said anorectal conditions in a patient; (b) formulating said composition by dispersing the four major active ingredients into a commercially accessible cream base; and (c) delivering an effective amount of said formulation topically to the affected areas of a patient in need thereof by way of bare finger, gloved finger, pad, swab, cloth, applicator, or patch; wherein said anorectal conditions comprise anal fissures, anal fistulas, anal itch, hemorrhoids, inflammatory bowel diseases, radiation colitis, radiation proctitis, and anorectal infections including bacterial infections, fungal infections, viral infections, and warts/condyomata, and said affected areas comprise the skin, the anus, rectum, anal verge, peri-anal areas, and perineum, and said patient is a human.", "5.A method of treatment of inflammation-related genitourinary medical conditions by delivering a composition according to claim 1, 2 or 3 comprising the steps of: (a) diagnosing one or more of said genitourinary conditions in a patient; (b) formulating said composition by dispersing the three major active ingredients into a commercially accessible base; and (c) delivering an effective amount of said formulation topically to the affected areas of a patient in need thereof by way of bare finger, gloved finger, pad, swab, cloth, applicator, or patch; wherein said genitourinary conditions comprise acute, chronic or recurrent prostatitis, bacterial or non-bacterial prostatitis, prostadynia, balanitis, balanoposthitis, balanitis xerotica obliterans, groin itch, scrotal itch, radiation cystitis, radiation vaginitis, radiation prostatitis, radiation urethritis, infectious and non-infectious urethritis, peri- and post-menopausal urethritis, peri- and post-menopausal vaginitis, atrophic urethritis, urethral syndrome, peri- and post-menopausal vaginitis, infectious and non-infectious vulvovaginitis, atrophic vaginitis, vaginal dryness, non-specific vaginal symptoms, pre- and post-coital discomfort and dyspareunia, vaginismus, vulvodynia, radiation vaginitis, and genitourinary infections including bacterial infections, fungal infections, viral infections, genital herpes, and warts/condyomata, and said affected areas comprise the skin, anus, rectum, external genitalia, scrotum, penis, vagina, labia, urethral meatus, peri-urethral area, peri-vaginal area, and perineum, and said patient is a human.", "6.The composition according to claims 1, 4 and 5 wherein said commercially accessible cream base may contain ingredients selected from the group consisting of mineral oil, petrolatum, paraffin, white wax, emulsifying wax, alcohol, glycerin, glycerol, glyceryl stearate, glyceryl triacetate, glycol, glycol stearate, alkyl benzoate, benzoic acid, benzyl alcohol, ceresin, cetearyl alcohol, cetostearyl alcohol, cetyl alcohol, cetyl ester, sodium cetostearyl sulphate, isopropyl myristate, isopropyl palmitate, lactic acid, lanolin, lanolin alcohol, methylchloroisothiazolinone, methylisothiazolinone, polydextrose, sorbic acid, sorbitan, stearate, stearic acid, stearyl alcohol, polysorbate, sodium hydroxide, parabens, phenoxyethanol, triethanolamine, sodium sulphite, sodium metabisulfite, propylene glycol, polyethylene glycol stearate, chlorocresol, sodium citrate, citric acid, sorbitol, maltitol, titanium dioxide, glyceryl polymethacrylate, polyethylene glycol glyceryl stearate, dimethiconol, dimethicone, ether, polyoxy stearate, polyethylene fatty acid ester, and combinations thereof, with its/their composition comprising about 0.001% to about 35% by weight of such an agent(s) and/or its salt(s), and with water comprising about 5% to about 65% by weight." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>Embodiments of the present disclosure generally relate to a novel method of treating various inflammation-related medical conditions comprising anorectal, genitourinary, musculoskeletal and dermatological conditions using various related, novel formulations.", "In exemplary embodiments, a topically-administered composition for treating inflammation-related medical conditions may include active ingredients and inactive ingredients, the active ingredients that may include (a) a corticosteroid ingredient, or salt thereof, selected from the group consisting of alclometasone dipropionate, amcinonide, beclomethasone, betamethasone benzoate, betamethasone dipropionate, betamethasone propionate, betamethasone valerate, budesonide, clobetasol propionate, clobetasone butyrate, clocortolone pivolate, cortisone, desonide, desoximetasone, dexamethasone, diflorasone diacetate, flumethasone pivolate, flunisolide, fluocinolone acetonide, fluocinonide, flurandrenolide, fluticasone propionate, halobetasol propionate, halocinonide, hydrocortisone, hydrocortisone acetate, hydrocortisone butyrate, hydrocortisone probutate, hydrocortisone propionate, hydrocortisone valerate, methylprednisolone, mometasone furoate, prednicarbate, prednisolone, prednisone acetate, prednisone valerate, triamcinolone acetonide, and triamcinolone hexaceto.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation-in-part of U.S. patent application Ser.", "No.", "12/927,845, filed Nov. 26, 2010, entitled “Methods of treatment of, and formulations for treatment of inflammation-related medical conditions,” and claims priority to U.S. provisional patent application Ser.", "No.", "61/283,665, filed Dec. 7, 2009, the disclosures of which are incorporated by reference herein in their entireties.", "BACKGROUND Field of the Invention This invention relates to a novel method of treating various inflammation-related medical conditions comprising anorectal, genitourinary, musculoskeletal and dermatological conditions using various related, novel formulations.", "Consumers and caregivers are often frustrated over.", "SUMMARY Embodiments of the present disclosure generally relate to a novel method of treating various inflammation-related medical conditions comprising anorectal, genitourinary, musculoskeletal and dermatological conditions using various related, novel formulations.", "In exemplary embodiments, a topically-administered composition for treating inflammation-related medical conditions may include active ingredients and inactive ingredients, the active ingredients that may include (a) a corticosteroid ingredient, or salt thereof, selected from the group consisting of alclometasone dipropionate, amcinonide, beclomethasone, betamethasone benzoate, betamethasone dipropionate, betamethasone propionate, betamethasone valerate, budesonide, clobetasol propionate, clobetasone butyrate, clocortolone pivolate, cortisone, desonide, desoximetasone, dexamethasone, diflorasone diacetate, flumethasone pivolate, flunisolide, fluocinolone acetonide, fluocinonide, flurandrenolide, fluticasone propionate, halobetasol propionate, halocinonide, hydrocortisone, hydrocortisone acetate, hydrocortisone butyrate, hydrocortisone probutate, hydrocortisone propionate, hydrocortisone valerate, methylprednisolone, mometasone furoate, prednicarbate, prednisolone, prednisone acetate, prednisone valerate, triamcinolone acetonide, and triamcinolone hexaceto.", "DETAILED DESCRIPTION This invention relates to a novel method of treating various inflammation-related medical conditions including anorectal and genitourinary conditions using various related, novel formulations.", "Consumers and caregivers are often frustrated over the relative lack of effective topical medical products in treating certain inflammatory medical conditions.", "Frequently, even after the acute infections or local traumas have subsided, with or without the use of anti-microbial agents, the inflammatory cascade lingers on, thus leading to chronic or recurrent inflammatory conditions.", "Symptoms attributable to such local inflammatory cascades may not respond to systematic treatments, which are often costly and morbid in the long run.", "Conversely, existing topical formulations are often limited by their suboptimal efficacy and slow relief of symptoms.", "This invention is a method of utilizing various combinations of topical preparations aiming at providing rapid relief and healing of acute, chronic and recurrent inflammatory anorectal and genitourinary conditions while minimizing the side effects of each of the individual ingredients.", "The formulations are highly versatile in that the composition of the ingredients can be varied and adjusted to treat a wide array of inflammatory conditions in these organ systems.", "Each of the formulations has a unique combination of several active ingredients, and each of these ingredients exerts its anti-inflammatory effects at various phases of the inflammatory cascade resulting in a synergistic effect of pain relief and healing.", "The first major active ingredient in the current formulations is selected from a member of the low-, mid-, or high-potency corticosteroids, which are known for their potent anti-inflammatory effects against a wide range of inflammations.", "Its anti-inflammatory mechanism is mediated through inhibition of prostaglandin synthesis and leukocyte response.", "Topical corticosteroid preparations, when applied in small quantities, have the advantage of modulating local immune response at the target sites while avoiding systemic side effects and drug interactions.", "The second major active ingredient described herein is an antidepressant agent(s) with anti-allergic and/or anti-itch properties which can counteract the propagation of the inflammatory cascade through anti-histaminic, serotonin and/or neuronal pathways.", "The third major active ingredient, a cooling/soothing agent(s), is crucial in providing immediate relaxation and soothing of the inflamed tissues such as the epithelial, sub-epithelial, mucosal tissues and nerve endings, and in aiding tissue penetration of other active ingredients, thus resulting in an instant relief of symptoms at the target sites.", "All these ingredients are combined in a commercially accessible cream base, with the overall efficacy resulting from the synergistic effect achieved via combining all or some of the above ingredients are superior to that of the individual ingredient alone.", "The antidepressant agents described herein specifically comprise antidepressants with anti-allergic and/or anti-itch properties, which can counteract the propagation of the inflammatory cascade through anti-histaminic, serotonin and/or neuronal pathways.", "They are intended to synergistically augment the anti-inflammatory potency of the corticosteroids and the anti-histaminic agents.", "Certain oral antidepressants have been implicated by some researchers as being capable of providing anti-allergic relief, presumably through anti-histaminic, serotonin and/or neuronal pathways (Hoffer, A., Journal of Orthomolecular Psychiatry, 1980, 9(3):164-170, http://www.orthomed.org/resources/papers/hofdepr.htm).", "For dermatological applications, the use of oral antidepressants following topical corticosteroid administration in treating lichen simplex chronicus has been found to be superior to conventional oral anti-histamines (Sanjana, V. D. & Fernandez, R. J., Indian J. Dermatol.", "Venereol.", "Leprol., 1992, 58:384-387).", "It follows that antidepressants, when added to other anti-inflammatory ingredients in various formulations of topical preparations as described herein, may enhance the overall safety margins while lessening the overall sedative side effects, thus achieving superior anti-inflammatory, anti-allergic and anti-itch effects.", "U.S. Pat.", "No.", "6,890,544 to McCadden discloses a gel composition for the topical treatment of poison ivy and other forms of contact dermatitis.", "The formulations included a corticosteroid, two drying agents consisting of calamine and zinc oxide, water and an anti-itch agent(s) selected from the group consisting of menthol, camphor, phenol, benzocaine, diphenylhydramine and pramoxine.", "The current invention differs substantially from the above cited patent in several ways including the fact that this invention contains a major active ingredient comprising an antidepressant with anti-allergic and/or anti-itch properties.", "For anorectal and genitourinary applications, while there is an abundance of formulations comprising corticosteroids and/or pramoxine, the use of a cooling agent(s) for treating such conditions for such organ systems is a rare application.", "For example, a non-prescriptive, mentholated herbal cream received good testimonials for multi-organ usages, including anorectal and genitourinary applications (Shaklee's Green Cream: www.barefoot-sun.com/2006/06/whats-in-your-medicine-cabinet.html).", "The addition of an anti-depressant with anti-allergic and/or anti-itch properties and a cooling or soothing agent(s) to a corticosteroid and an emollient/moisturizing agent(s) for the treatment of anorectal and genitourinary conditions is unknown in the prior art.", "By way of example, the addition of a cooling agent(s) to a topical analgesic was demonstrated to facilitate the penetration of the latter, thus enhancing its efficacy, by effecting changes in the epidermal ultra structure (Liu, Y., et al, International J. Pharmaceutics, 2005, 305(1-2):31-36).", "In another study, a cooling agent(s), when added to a cetylated fatty acid topical cream, was shown to reduce pain and improve the functional performance in individuals with arthritis (Kraemer, W., et al, J.", "Strength and Conditioning Research, 2005, 19(2):475-480).", "In summary, while there is an abundance of patents and literature on the various combinations of active ingredients in treating various inflammation-related medical conditions, the addition of an anti-depressant with anti-allergic and/or anti-itch properties described herein to the other two major active ingredients comprising a corticosteroid and a cooling or soothing agent(s) in treating various anorectal and genitourinary conditions has not been described in the prior art.", "The invention relates to novel methods of treatment of various inflammation-related anorectal and genitourinary conditions using various related, novel formulations containing the selected active ingredients, which are dispersed in commercially accessible base formulations such as a cream.", "The invention also relates to novel methods of treatment of various anorectal and genitourinary conditions using various novel formulations containing the three major ingredients as described above.", "Specific compositions of the three major active ingredients are selected depending on the nature of the target tissues, the etiologies of inflammation and the severity of symptoms.", "Taken altogether, the multi-active ingredient formulations described herein allow each of these ingredients to exist at a lower concentration than existing single-active ingredient formulations, thus minimizing the likelihood for side effects due to systemic absorption and toxicity.", "The latter has been the major concern for oral or parenteral administrations of pharmaceutical agents.", "Such symptoms, in the case of prolonged corticosteroid use, may include reversible hypothalamic-pituitary-adrenal axis suppression, manifestations of Cushing's syndrome, hyperglycemia and glucosuria, and in the case of excessive application of an anti-histaminic/anti-allergic, anti-itch agent(s), may include drowsiness and sedation.", "On the contrary, systemic absorption leading to clinical symptoms is a rare occurrence using the formulations described for anorectal and genitourinary administrations wherein only a small amount of the formulated product is applied, for example, on the tip of a finger, pad, swab, cloth or an applicator, and then transferred to the target sites.", "Alternatively, formulations may be delivered via a patch, providing immediate or controlled release of the formulation.", "The formulations of this invention contain lower amounts of each of the multiple active ingredients in lieu of a formulation that contains a larger concentration of a single active ingredient.", "This is because in the latter preparation, the single active ingredient will have to exist in a much larger quantity in order to achieve the comparable clinical efficacy as the multi-active ingredient formulations.", "For example, the concern for local untoward side effects such as atrophic changes, telangiectasia and depigmentation of the skin, the mucosal/epithelial linings, the anal verge and vaginal introitus following long-term use of topical steroids at a high concentration can be effectively lessened.", "The idea leading to the current formulation development parallels the concept of utilizing the multi-drug approach in developing modern chemotherapeutic regimens, i.e., delivering a higher overall efficacy with a wider safety margin and fewer complications when compared to the single-drug regimens.", "This invention relates to novel methods of treatment of various inflammation-related anorectal and genitourinary conditions using various novel formulations containing the three major ingredients as described above comprising a corticosteroid, an antidepressant agent(s) with anti-allergic and/or anti-itch properties and a cooling/soothing agent(s).", "As further described, the above selected active ingredients are dispersed in commercially accessible cream base formulations.", "Specific ingredients are selected depending on the nature of the target tissues, the etiologies of inflammation and the severity of symptoms.", "The invention consists of a method of utilizing various combinations of topical preparations aiming at providing rapid relief and healing of acute, chronic and recurrent inflammatory anorectal and genitourinary conditions while minimizing the side effects of each of the individual ingredients.", "The formulations are highly versatile in that the composition of the ingredients can be varied and adjusted to treat a wide array of inflammatory conditions in these organ systems.", "To maximize its efficacy, each of the formulations has a unique combination of several active ingredients, and each of these ingredients exerts its anti-inflammatory effect at various phases of the inflammatory cascade, resulting in a synergistic effect of pain relief and healing.", "To minimize the side effects, the current multi-active ingredient formulations allow each of these ingredients to exist at a lower concentration than the existing single-active ingredient formulations, thus minimizing the likelihood for side effects due to systemic absorption and toxicity.", "Over the years as a practicing urologist, I have observed how some patients suffered from untoward systemic side effects of various hormonally based vaginal creams/gels/lotions, etc., including gynecomastia, flushing, skin irritations, vulvar ulcerations, etc.", "These topical preparations are often administered in large quantities (e.g., with a vaginal syringe applicator) in order to elicit adequate clinical response.", "However, such a conventional administration of a high quantity of a single drug locally can often cause significant local symptoms and even irreversible skin changes.", "Similar observations were made on my patients who were given long-term, full-strength corticosteroid creams/gels/lotions, etc.", "for various dermatological conditions, and subsequently developed severe atrophic dermatitis, skin thinning, hypopigmentation, easy bruisibility, skin cracking and bleeding, etc.", "The various components in specific combinations can raise the thresholds for toxicities and side effects of each of their individual components, while achieving a superior outcome due to their synergistic effects, e.g., relieving the inflammatory dermatological conditions while avoiding skin thinning and other side effects associated with long-term corticosteroid use.", "In order to maximize efficacy, the claimed compositions have unique combinations of several active ingredients, and each of these ingredients exerts its anti-inflammatory effect at various phases of the inflammatory cascade, resulting in a synergistic effect of pain relief and healing.", "In order to minimize side effects, the current claimed multi-active ingredient compositions allow each of these ingredients to exist at a lower concentration than the existing single-active ingredient compositions, thus minimizing the likelihood for side effects due to systemic absorption and toxicity.", "A method of treatment of and formulations for treatment of anorectal conditions.", "The pathophysiology of symptoms related to various anorectal conditions shares the final common inflammatory pathway of pain and swelling of the tissues involved, such as the anal verge, perineum, hemorrhoidal tissues/veins, anal ulcerations, fissure and fistula formation and anal, peri-anal, rectal and peri-rectal mucosal and epithelial linings, leading to venous congestion/thrombosis, mucosal and submucosal edema/inflammation, etc.", "All treatment options aim at relief of tissue swelling and inflammation, the leading cause of pain and discomfort.", "Current topical preparations for treatments of anorectal conditions, either prescriptive or non-prescriptive formulations, have been mostly developed for the treatments of hemorrhoids and anal fissures, and have been limited to products containing one or two active ingredients comprising pramoxine, decongestants, corticosteroids, analgesics.", "The method of treatment for the anorectal conditions using the formulations described herein is novel, unique and different from any methods of treatment using any of the existing patented prescriptive and non-prescriptive formulations including those indicated for use in various anorectal conditions such as anal fissures, anal fistulas, anal itch, hemorrhoids, inflammatory bowel diseases, radiation colitis, radiation proctitis, and anorectal infections including bacterial infections, fungal infections, viral infections, and warts/condyomata.", "Each of the formulations has a unique combination of several active ingredients as described in the claims, and each of these ingredients exerts its anti-inflammatory effects at various phases of the inflammatory cascade resulting in a synergistic effect of pain relief and healing.", "The first major active ingredient in the anorectal formulations described herein is selected from a member of the low-, mid-, or high-potency corticosteroids, which are known for their potent anti-inflammatory effects against a wide range of inflammations.", "Its anti-inflammatory mechanism is mediated through inhibition of prostaglandin synthesis and leukocyte response.", "Topical corticosteroid preparations, when applied in small quantities, have the advantage of modulating local immune response at the target sites while avoiding systemic side effects and drug interactions.", "The second major active ingredient in the anorectal formulations described herein is an antidepressant agent(s) with anti-allergic and/or anti-itch properties which can counteract the propagation of the inflammatory cascade through anti-histaminic, serotonin and/or neuronal pathways.", "The third major active ingredient in the anorectal formulations described herein is a cooling/soothing agent(s), which is crucial in providing immediate relaxation and soothing of the inflamed tissues such as the epithelial, sub-epithelial, mucosal tissues and nerve endings, and in aiding tissue penetration of other active ingredients, thus resulting in an instant relief of symptoms at the target sites.", "All these ingredients are combined in a commercially accessible cream base, with the overall efficacy resulting from the synergistic effect achieved via combining all or some of the above ingredients are superior to that of the individual ingredient alone.", "The novel method of treatment of various anorectal conditions using various novel formulations containing the above three major ingredients are dispersed as an admixture in a commercially accessible cream base formulation.", "Taken altogether, the current multi-active ingredient in the anorectal formulations described herein allow each of these ingredients to exist at a lower concentration than the existing single-active ingredient formulations, thus minimizing the likelihood for side effects due to systemic absorption and toxicity.", "The latter has been the major concern for oral or parenteral administrations of pharmaceutical agents.", "Such symptoms, in the case of prolonged corticosteroid use, may include reversible hypothalamic-pituitary-adrenal axis suppression, manifestations of Cushing's syndrome, hyperglycemia and glucosuria, and in the case of excessive application of an anti-histaminic/anti-allergic, anti-itch agent(s), may include drowsiness and sedation.", "On the contrary, systemic absorption leading to clinical symptoms is a rare phenomenon using the formulations as described herein for anorectal administrations, wherein only a small amount of the formulated product is applied on the tip of a finger, pad, swab, cloth or an applicator and then transferred to the target sites comprising the skin, the anus, rectum, anal verge, peri-anal areas, and perineum.", "To further enhance its safety margin and efficacy, the anorectal formulations of this invention described herein use lower amounts of each of the multiple active ingredients in lieu of a formulation that contains a larger concentration of a single active ingredient.", "This is because in the latter preparation, the single active ingredient will have to exist in a much larger quantity in order to achieve the comparable clinical efficacy as the multi-active ingredient formulations.", "For example, the concern for local untoward side effects such as atrophic changes and telangiectasia in the mucosal/epithelial linings and the anal verge following long-term use of topical steroids at a high concentration can be effectively lessened.", "The idea leading to the current formulation development parallels the concept of utilizing the multi-drug approach in developing modern chemotherapeutic regimens, i.e., delivering a higher overall efficacy with fewer complications when compared to the single-drug regimens.", "The formulations for treatment of anorectal conditions described herein comprise the following selected active ingredients, which are dispersed as an admixture in commercially accessible base formulations.", "Specifically, the formulations comprise a low-, mid-, or high-potency corticosteroid selected from a listing comprising the following agents/ingredients and/or their salts: alclometasone dipropionate, amcinonide, beclomethasone, betamethasone benzoate, betamethasone dipropionate, betamethasone propionate, betamethasone valerate, budesonide, clobetasol propionate, clobetasone butyrate, clocortolone pivolate, cortisone, desonide, desoximetasone, dexamethasone, diflorasone diacetate, flumethasone pivolate, flunisolide, fluocinolone acetonide, fluocinonide, flurandrenolide, fluticasone propionate, halobetasol propionate, halocinonide, hydrocortisone, hydrocortisone acetate, hydrocortisone butyrate, hydrocortisone probutate, hydrocortisone propionate, hydrocortisone valerate, methylprednisolone, mometasone furoate, prednicarbate, prednisolone, prednisone acetate, prednisone valerate, triamcinolone acetonide, and triamcinolone hexacetonide, with its composition comprising about 0.0005% to about 10% by weight of such an agent(s).", "More specifically, the low-mid to mid-potency corticosteroids are selected from a listing comprising the following agents/ingredients and/or their salts: alclometasone dipropionate, clobetasone butyrate, clocortolone pivolate, cortisone, desoximetasone, dexamethasone, hydrocortisone, hydrocortisone acetate, hydrocortisone butyrate, hydrocortisone propionate, hydrocortisone probutate, hydrocortisone valerate, methylprednisolone, prednisolone, prednisone acetate, prednisone valerate, triamcinolone acetonide, and triamcinolone hexacetonide, with its composition comprising about 0.005% to about 10%, preferably about 0.01% to about 5%, and more preferably from about 0.05% to about 2.5% by weight of such an agent(s).", "When mid- to high-potency corticosteroids are used, they are selected from a listing comprising the following agents/ingredients and/or their salts: amcinonide, beclomethasone, betamethasone benzoate, betamethasone dipropionate, betamethasone propionate, betamethasone valerate, budesonide, clobetasol propionate, desonide, diflorasone diacetate, flumethasone pivolate, flunisolide, fluocinolone acetonide, fluocinonide, flurandrenolide, fluticasone propionate, halobetasol propionate, halocinonide, mometasone furoate, and prednicarbate, with its composition comprising about 0.0005% to about 5%, preferably about 0.01% to about 3%, and more preferably from about 0.05% to about 1% by weight of such an agent(s).", "The formulations for treatment of anorectal conditions also contain an antidepressant agent(s) with anti-allergic and/or anti-itch properties which is selected from a listing comprising the following agents/ingredients and/or their salts: agomelatine, amitryptiline, amoxapine, bupropion, buspirone, carbamazepine, citalopram, clomipramine, desipramine, desvenlafaxine, dexmethylphenidate, dextromethorphan, dosulepin, doxepin, duloxetine, escitalopram, fluoxetine, fluvoxamine, imipramine, isocarboxazid, lamotrigine, lisdexamfetamine, lofepramine, maprotiline, methylphenidate, mianserin, milnacipran, mirtazapine, moclobemide, nefazodone, nortriptyline, opipramol, paroxetine, phenelzine, pirlindole, protriptyline, reboxetine, selegiline, sertraline, sibutramine, tandospirone, tianeptine, tramadol, tranylcypromine, trazodone, trimipramine, valproic acid, venlafaxine, and viloxazine, with its composition comprising about 0.005% to about 20%, preferably about 0.1% to about 10%, and more preferably from about 0.2% to about 5% by weight of such an agent(s).", "The formulations for treatment of anorectal conditions also comprise a cooling/soothing agent(s) which is/are selected from a listing comprising the following agents/ingredients and/or their salts/oils: camphor, camphor oil, cinnamon oil, citronella oil, cornmint oil, eucalyptus oil, menthol, methyl salicylate, peppermint oil, and combinations thereof, with its/their composition comprising about 0.001% to about 15%, preferably about 0.1% to about 7.5%, and more preferably from about 0.2% to about 5% by weight of such an agent(s).", "2.A method of treatment of and formulations of treatment of genitourinary conditions.", "The pathophysiology of symptoms related to various genitourinary conditions shares the final common inflammatory pathway of pain and swelling of the tissues involved, such as the urethral, peri-urethral, vaginal mucosa, labial, vulvar, peri-vaginal, perineal, penile and scrotal epithelia, leading to mucosal and submucosal edema/inflammation, etc.", "All treatment options aim at relief of tissue swelling and inflammation—the leading cause of pain and discomfort.", "Current topical preparations for treatments of genitourinary conditions, either prescriptive or non-prescriptive formulations, have been mostly developed for the treatments of post-menopausal atrophic vaginal changes, and often contain one or two active ingredients comprising female sex hormone derivatives, corticosteroids, etc.", "The method of treatment for the genitourinary conditions using the formulations described herein is novel, unique and different from any methods of treatment using any of the existing patented formulations including prescriptive and non-prescriptive formulations currently indicated for use in various genitourinary conditions such as acute, chronic or recurrent prostatitis, bacterial or non-bacterial prostatitis, prostadynia, balanitis, balanoposthitis, balanitis xerotica obliterans, groin itch, scrotal itch, radiation cystitis, radiation vaginitis, radiation prostatitis, radiation urethritis, infectious and non-infectious urethritis, peri- and post-menopausal urethritis, peri- and post-menopausal vaginitis, atrophic urethritis, urethral syndrome, peri- and post-menopausal vaginitis, infectious and non-infectious vulvovaginitis, atrophic vaginitis, vaginal dryness, non-specific vaginal symptoms, pre- and post-coital discomfort and dyspareunia, vaginismus, vulvodynia, radiation vaginitis, and genitourinary infections including bacterial infections, fungal infections, viral infections, genital herpes, and warts/condyomata.", "Each of the formulations for treatment of genitourinary conditions has a unique combination of several active ingredients, and each of these ingredients exerts its anti-inflammatory effects at various phases of the inflammatory cascade resulting in a synergistic effect of pain relief and healing.", "The first major active ingredient in the current formulations is selected from a member of the low-, mid-, or high-potency corticosteroids, which are known for their potent anti-inflammatory effects against a wide range of inflammations.", "Its anti-inflammatory mechanism is mediated through inhibition of prostaglandin synthesis and leukocyte response.", "Topical corticosteroid preparations, when applied in small quantities, have the advantage of modulating local immune response at the target sites while avoiding systemic side effects and drug interactions.", "The second major active ingredient described herein is an antidepressant agent(s) with anti-allergic and/or anti-itch properties which can counteract the propagation of the inflammatory cascade through anti-histaminic, serotonin and/or neuronal pathways.", "The third major active ingredient, a cooling or soothing agent(s), is crucial in providing immediate relaxation and soothing of the inflamed tissues such as the epithelial, sub-epithelial, mucosal tissues and nerve endings, and in aiding tissue penetration of other active ingredients, thus resulting in an instant relief of symptoms at the target sites.", "All these ingredients are combined in a commercially accessible cream base, with the overall efficacy resulting from the synergistic effect achieved via combining all or some of the above ingredients are superior to that of the individual ingredient alone.", "The novel method of treatment of various genitourinary conditions using various novel formulations containing the above four major ingredients are dispersed as an admixture in a commercially accessible cream base formulation.", "Taken altogether, the current multi-active ingredient formulations allow each of these ingredients to exist at a lower concentration than the existing single-active ingredient formulations, thus minimizing the likelihood for side effects due to systemic absorption and toxicity.", "The latter has been the major concern for oral or parenteral administrations of pharmaceutical agents.", "Such symptoms, in the case of prolonged corticosteroid use, may include reversible hypothalamic-pituitary-adrenal axis suppression, manifestations of Cushing's syndrome, hyperglycemia and glucosuria, and in the case of excessive application of an anti-histaminic/anti-allergic, anti-itch agent(s), may include drowsiness and sedation.", "On the contrary, systemic absorption leading to clinical symptoms is a rare phenomenon using the formulations as described herein for genitourinary administrations, wherein only a small amount of the formulated product is applied on the tip of a finger, pad, swab, cloth or an applicator and then transferred to the target sites comprising the skin, anus, rectum, external genitalia, scrotum, penis, vagina, labia, urethral meatus, peri-urethral area, peri-vaginal area, and perineum.", "To further enhance its safety margin and efficacy, these formulations consist of smaller amounts of each of the multiple active ingredients in lieu of a formulation that contains a larger concentration of a single active ingredient.", "This is because in the latter preparation, the single active ingredient will have to exist in a much larger quantity in order to achieve the comparable clinical efficacy as the multi-active ingredient formulations.", "For example, the concern for local untoward side effects such as atrophic changes and telangiectasia in the skin or mucosal/epithelial linings following long-term use of topical steroids at a high concentration can be effectively lessened.", "The idea leading to the current formulation development parallels the concept of utilizing the multi-drug approach in developing modern chemotherapeutic regimens, i.e., delivering a higher overall efficacy with fewer complications when compared to the single-drug regimens.", "The formulations for treatment of genitourinary conditions described herein comprise the following selected active ingredients, which are dispersed as an admixture in commercially accessible base formulations.", "Specifically, the formulations comprise a low-, mid-, or high-potency corticosteroid selected from a listing comprising the following agents/ingredients and/or their salts: alclometasone dipropionate, amcinonide, beclomethasone, betamethasone benzoate, betamethasone dipropionate, betamethasone propionate, betamethasone valerate, budesonide, clobetasol propionate, clobetasone butyrate, clocortolone pivolate, cortisone, desonide, desoximetasone, dexamethasone, diflorasone diacetate, flumethasone pivolate, flunisolide, fluocinolone acetonide, fluocinonide, flurandrenolide, fluticasone propionate, halobetasol propionate, halocinonide, hydrocortisone, hydrocortisone acetate, hydrocortisone butyrate, hydrocortisone probutate, hydrocortisone propionate, hydrocortisone valerate, methylprednisolone, mometasone furoate, prednicarbate, prednisolone, prednisone acetate, prednisone valerate, triamcinolone acetonide, and triamcinolone hexacetonide, with its composition comprising about 0.0005% to about 10% by weight of such an agent(s).", "More specifically, the low-mid to mid-potency corticosteroids are selected from a listing comprising the following agents/ingredients and/or their salts: alclometasone dipropionate, clobetasone butyrate, clocortolone pivolate, cortisone, desoximetasone, dexamethasone, hydrocortisone, hydrocortisone acetate, hydrocortisone butyrate, hydrocortisone propionate, hydrocortisone probutate, hydrocortisone valerate, methylprednisolone, prednisolone, prednisone acetate, prednisone valerate, triamcinolone acetonide, and triamcinolone hexacetonide, with its composition comprising about 0.005% to about 10%, preferably about 0.01% to about 5%, and more preferably from about 0.05% to about 2.5% by weight of such an agent(s).", "When mid- to high-potency corticosteroids are used, they are selected from a listing comprising the following agents/ingredients and/or their salts: amcinonide, beclomethasone, betamethasone benzoate, betamethasone dipropionate, betamethasone propionate, betamethasone valerate, budesonide, clobetasol propionate, desonide, diflorasone diacetate, flumethasone pivolate, flunisolide, fluocinolone acetonide, fluocinonide, flurandrenolide, fluticasone propionate, halobetasol propionate, halocinonide, mometasone furoate, and prednicarbate, with its composition comprising about 0.0005% to about 5%, preferably about 0.01% to about 3%, and more preferably from about 0.05% to about 1% by weight of such an agent(s).", "The formulations for treatment of genitourinary conditions also contain an antidepressant agent(s) with anti-allergic and/or anti-itch properties which is selected from a listing comprising the following agents/ingredients and/or their salts: agomelatine, amitryptiline, amoxapine, bupropion, buspirone, carbamazepine, citalopram, clomipramine, desipramine, desvenlafaxine, dexmethylphenidate, dextromethorphan, dosulepin, doxepin, duloxetine, escitalopram, fluoxetine, fluvoxamine, imipramine, isocarboxazid, lamotrigine, lisdexamfetamine, lofepramine, maprotiline, methylphenidate, mianserin, milnacipran, mirtazapine, moclobemide, nefazodone, nortriptyline, opipramol, paroxetine, phenelzine, pirlindole, protriptyline, reboxetine, selegiline, sertraline, sibutramine, tandospirone, tianeptine, tramadol, tranylcypromine, trazodone, trimipramine, valproic acid, venlafaxine, and viloxazine, with its composition comprising about 0.005% to about 20%, preferably about 0.1% to about 10%, and more preferably from about 0.2% to about 5% by weight of such an agent(s).", "The formulations for treatment of genitourinary conditions also comprise a cooling/soothing agent(s) which is/are selected from a listing comprising the following agents/ingredients and/or their salts/oils: camphor, camphor oil, cinnamon oil, citronella oil, cornmint oil, eucalyptus oil, menthol, methyl salicylate, peppermint oil, and combinations thereof, with its/their composition comprising about 0.001% to about 15%, preferably about 0.1% to about 7.5%, and more preferably from about 0.2% to about 5% by weight of such an agent(s).", "It should be emphasized that the above-described embodiments of the present disclosure are merely possible examples of implementations, merely set forth for a clear understanding of the principles of the disclosure.", "Many variations and modifications may be made to the above-described embodiment(s) of the disclosure without departing substantially from the spirit and principles of the disclosure.", "All such modifications and variations are intended to be included herein within the scope of this disclosure and the present disclosure and protected by the following claims.", "While the foregoing is directed to embodiments of the present invention, other and further embodiments of the invention may be devised without departing from the basic scope thereof.", "For example, although numerous embodiments having various features have been described herein, combinations of such various features in other combinations not discussed herein are contemplated within the scope of embodiments of the present invention." ] ]
Patent_15876101
[ [ "NOVEL PRESSURELESS IRRIGATION DEVICE", "The present disclosure belongs to the technical field of farm irrigation, and particularly relates to a novel pressureless irrigation device.", "The novel pressureless irrigation device of the present disclosure uniformly conveys irrigation water to crop plant root systems on the basis of a “connector” principle; and the size of a flow cross-section necessarily satisfies the extremely-low flowing speed requirement of “lossless conveyance” for the “connector” in a static pressure dominant operating state, thereby eliminating a problem of irrigator blockage which accompanies energy dissipation.", "Water enters the atmosphere via transpiration of crop plants, and a water supply water level control pool at a head portion is triggered to replenish the water.", "The water consumption and water replenishment are adaptive, and human intervention and additional energy are not required, thereby realizing low-cost and “fool-proof” automatic irrigation and true sense of uniform irrigation." ], [ "1.A novel pressureless irrigation device, comprising a novel irrigator for the novel pressureless irrigation device, wherein the novel irrigator comprises an equal-diameter downstream tee joint (1), a horizontal water inlet end (1-1) of the equal-diameter downstream tee joint, a horizontal water outlet end (1-2) of the equal-diameter downstream tee joint, a vertical water inlet end (1-3) of the equal-diameter downstream tee joint, a connecting pipe (2), a reducer pipe (3), a soil saturated water layer forming pipe (4), a porous water-permeable plate (5), a sandstone inverted filter layer (6) and backfill soil (7); the equal-diameter downstream tee joint (1) is connected to underground capillary pipes in series; the horizontal water inlet end (1-1) of the equal-diameter downstream tee joint is connected with a head end direction of one capillary pipe; the horizontal water outlet end (1-2) of the equal-diameter downstream tee joint is connected with a rear end direction of the capillary pipe; head ends of all capillary pipes are communicated with water supply water level control pool (201) by water supply branch pipes and water supply main pipes; rear ends of all the capillary pipes are connected with capillary pipe flushing valves by drainage branch pipes and drainage main pipes; the water supply branch pipes, the drainage branch pipes, the drainage main pipes and all the capillary pipes are located on a same horizontal plane; when noncapillary pipes perform flushing operation, the flushing valves are in a closed state; the vertical water inlet end (1-3) of the equal-diameter downstream tee joint is connected with a small head of the reducer pipe (3) by the connecting pipe (2); a lower end of the soil saturated water layer forming pipe (4) is vertically inserted into a large head of the reducer pipe (3); the porous water-permeable plate (5) is placed at the bottom of the soil saturated water layer forming pipe (4) and on one side of the large head of a diameter reducing position of the reducer pipe (3); the sandstone inverted filter layer (6) is placed on the porous water-permeable plates (5); the backfill soil (7) is placed on the sandstone inverted filter layer (6); a distance between a top end of the soil saturated water layer forming pipe (4) and a soil surface of an irrigated farmland is 40-45 cm; a height adjustment range of a soil saturated water layer is from the bottom of the backfill soil (7) in the soil saturated water layer forming pipe (4) to a top of the soil saturated water layer forming pipe (4); and a height of the soil saturated water layer is adjusted by adjusting a water level of a corresponding water level control pool for water supply (201).", "2.The novel pressureless irrigation device according to claim 1, further comprising a floating ball water level control device having a water level adjustment control mechanism and a gauge, wherein a water inlet pipe (202) of the water supply water level control pool (201) horizontally penetrates through a side wall of the water supply water level control pool (201) from right to left and enters the water supply water level control pool (201); the water inlet pipe is connected with a port at right side of an equal-diameter tee (203), and the port is perpendicular to an upper port and a lower port of the equal-diameter tee (203); a lower end of an upper connecting pipe (204) is connected with the upper port of the equal-diameter tee (203); an upper end of the upper connecting pipe (204) is connected with the lower end of a female adapter (205); a square plug (206) is mounted at the upper end of the female adapter (205); the upper end of a lower connecting pipe (207) is connected with the lower port of the equal-diameter tee (203); the lower end of the lower connecting pipe (207) is connected with the upper port of a ball valve (208); the lower port of the ball valve (208) is connected with the upper end of a water distribution pipe (209); the water distribution pipe (209) has a suspended lower end and a downward pipe port; a horizontal head-on surface of a valve rod (210) of the ball valve (208) is inward, is perpendicular to a plane on which the upper connecting pipe (204), the lower connecting pipe (207) and the water inlet pipes (202) in the water supply water level control pool (201) are located; perpendicular to the plane, a right upper shaft (211) is fixed inwards and horizontal to the head-on surface at an upper portion of the upper connecting pipe (204); a right end of the upper connecting rod (212) is sleeved on a right upper shaft (211) after being drilled, and then the upper connecting rod (212) is equipped with a circular gasket and a gasket fixing plug pin; the upper connecting rod (212) is rotatable about the right upper shaft (211) in the plane perpendicular to the right upper shaft (211); a right end of the lower connecting rod (213) is fixed to the valve rod (210); when a left end and a right end of the lower connecting rod (213) are located on a same horizontal plane, the ball valve (208) is in a closed state; when the left end of the lower connecting rod (213) is separated from the horizontal plane and moves downwards, the valve rod (210) is drivable to rotate to open the closed ball valve (208); a left lower shaft (215) is fixed inwards to a head-on surface of the valve rod (210) parallel to the valve rod (210) at a lower end of a sleeve (214); the left end of the lower connecting rod (213) is sleeved on the left lower shaft (215) after being drilled and then is equipped with a circular gasket and a gasket fixing plug pin; a left upper shaft (216) is fixed inwards and horizontal to the head-on surface and parallel to the right upper shaft (211) on the sleeve (214) at a position with a distance equal to a distance between the valve rod (210) and the right upper shaft (211) above the left lower shaft (215); the left end of the upper connecting rod (212) is sleeved on the left upper shaft (216) after drilled and then is equipped with a circular gasket and a gasket fixing plug pin; a distance between the right upper shaft (211) and the left upper shaft (216) is equal to a distance between the valve rod (210) and the left lower shaft (215); a pull ring (218) is fixed at a upper end of a floating box connecting rod (217); a water-level control gauge (219) is arranged on a upper portion of the floating box connecting rod (217) and on the floating box connecting rod (217) below the pull ring (218); a lower end of the floating box connecting rod (217) penetrating through the sleeve (214) is fixed to a floating box (221) by a fixing nut (220) on the floating box (221); a control water level positioning pin (222) is mounted on an upward extended section of the sleeve (214) and on the sleeve (214) at a height higher than an upper cover plate of the water supply water level control pool (201) and convenient to operate above the left upper shaft (216); the upper connecting rod (212) and the lower connecting rod (213) move in the same plane perpendicular to the valve rod (210), the right upper shaft (211), the left lower shaft (215) and the left upper shaft (216); a pipe port at one end of the water outlet pipe (223) of the water supply water level control pool (201) penetrates through a side wall of the water supply water level control pool (201), and the pipe port is located at the bottom of the water supply water level control pool (201) with 20-25 cm higher than a bottom surface of the water supply water level control pool (201); and the other end of the water outlet pipe (223) of the water supply water level control pool (201) is connected with a water supply main pipe in the novel irrigator of the novel pressureless irrigation device.", "3.The novel pressureless irrigation device according to claim 1, further comprising a photovoltaic water supply system for the novel irrigator of the novel pressureless irrigation device; the photovoltaic water supply system comprises a photovoltaic water pumping portion, a water reservoir and the water supply water level control pool (201); the photovoltaic water pumping portion is composed of a solar battery array, a photovoltaic water pumping invertor and a water pump; the solar battery array is configured on the water reservoir; the water pump is configured at a bottom in a water source well; a water pump water outlet pipe is mounted on a water outlet of the water pump; the pipe port at the other end of the water pump water outlet pipe is located above the water reservoir and the mouth of the pipe port is downward; an overflow pipe is arranged on an upper portion of the water reservoir; a water inlet pipe port of the overflow pipe is configured on a side wall of the water reservoir; the pipe port is located in the water reservoir and the port pipe is 10-15 cm lower than an upper edge of the side wall of the water reservoir; the other end of the overflow pipe is located outside the water reservoir and has the water outlet pipe port placed in a water source well; one end of the water inlet pipe (202) of the water supply water level control pool (201) is connected with the water reservoir; the pipe port at one end of the water inlet pipe (202) connected with the water reservoir penetrates through the side wall of the water reservoir, and the pipe port is located in the water reservoir with 15-20 cm higher than the bottom surface of the water reservoir; the other end of the water inlet pipe (202) of the water supply water level control pool (201) horizontally penetrates through the side wall of the water supply water level control pool (201) from right to left and enters the water supply water level control pool (201); the water inlet pipe is connected with a port at right side of the equal-diameter tee (203), and the port is perpendicular to an upper port and a lower port of the equal-diameter tee (203); the lower end of the upper connecting pipe (204) is connected with the upper port of the equal-diameter tee (203); the upper end of the upper connecting pipe (204) is connected with the lower end of the female adapter (205); the square plug (206) is mounted at the upper end of the female adapter (205); the upper end of the lower connecting pipe (207) is connected with the lower port of the equal-diameter tee (203); the lower end of the lower connecting pipe (207) is connected with the upper port of the ball valve (208); the lower port of the ball valve (208) is connected with the upper end of the water distribution pipe (209); the water distribution pipe (209) has the suspended lower end and the downward pipe port; the valve rod (210) of the ball valve (208) is facing inward and horizontal to the head-on surface, and the valve rod is perpendicular to the plane on which the upper connecting pipe (204), the lower connecting pipe (207) and the water inlet pipes (202) in the water supply water level control pool (201) are located; perpendicular to the plane, the right upper shaft (211) is fixed inwards and horizontal to the head-on surface at the upper portion of the upper connecting pipe (204); the right end of the upper connecting rod (212) is sleeved on the right upper shaft (211) after being drilled, and then the upper connecting rod is equipped with the circular gasket and the gasket fixing plug pin; the upper connecting rod (212) is rotatable about the right upper shaft (211) in the plane perpendicular to the right upper shaft (211); the right end of the lower connecting rod (213) is fixed to the valve rod (210); when the left end and the right end of the lower connecting rod (213) are located on the same horizontal plane, the ball valve (208) is in the closed state; when the left end of the lower connecting rod (213) is separated from the horizontal plane and moves downwards, the valve rod (210) is drivable to rotate to open the closed ball valve (208); the left lower shaft (215) is fixed inwards and parallel to the head-on surface of the valve rod (210) at the lower end of the sleeve (214); the left end of the lower connecting rod (213) is sleeved on the left lower shaft (215) after being drilled and then the lower connecting rod (213) is equipped with the circular gasket and the gasket fixing plug pin; the left upper shaft (216) is fixed inwards, horizontal to the head-on surface and parallel to the right upper shaft (211) on the sleeve (214) at a position with a distance equal to a distance between the valve rod (210) and the right upper shaft (211) above the left lower shaft (215); the left end of the upper connecting rod (212) is sleeved on the left upper shaft (216) after being drilled and then the upper connecting rod (212) is equipped with the circular gasket and the gasket fixing plug pin; the distance between the right upper shaft (211) and the left upper shaft (216) is equal to the distance between the valve rod (210) and the left lower shaft (215); the pull ring (218) is fixed at the upper end of the floating box connecting rod (217); the control level gauge (219) is arranged on the upper portion of the floating box connecting rod (217) and the floating box connecting rod (217) below the pull ring (218); the lower end of the floating box connecting rod (217) penetrating through the sleeve (214) is fixed to the floating box (221) by the fixing nut (210) on the floating box (221); the control water level positioning pin (222) is mounted on the upward extended section of the sleeve (214) and on the sleeve (214) at the height higher than an upper cover plate of the water supply water level control pool (201) and convenient to operate above the left upper shaft (216); the upper connecting rod (212) and the lower connecting rod (213) move in the same plane perpendicular to the valve rod (210), the right upper shaft (211), the left lower shaft (215) and the left upper shaft (216); the pipe port at one end of the water outlet pipe (223) of the water supply water level control pool (201) penetrates through the side wall of the water supply water level control pool (201), and the pipe port is located in the water supply water level control pool (201), with 20-25 cm higher than the bottom surface of the water supply water level control pool (201); and the other end of the water outlet pipes (223) of the water supply water level control pool (201) is connected with the water supply main pipe in the novel irrigator for the novel pressureless irrigation device.", "4.The novel pressureless irrigation device according to claim 3, wherein the water reservoir and the photovoltaic water pumping portion are replaced with a water source with a minimum dynamic water level higher than a water level of the water supply water level control pool (201); and one end of the water inlet pipe (202) of the water supply water level control pool (201) is connected with the water sources.", "5.The novel pressureless irrigation device according to claim 3, wherein the novel irrigator and the novel water supply system for the novel irrigator uniformly convey the irrigation water to the crop plant root systems; the novel irrigator and the water supply water level control pool (201) are based on the “connector” principle; and a size of the flow cross-section satisfies extremely-low flowing speed requirement of “lossless conveyance” for the “connector” in a static pressure dominant operating state.", "6.The novel pressureless irrigation device according to claim 1, wherein a distance between the top end of the soil saturated water layer forming pipe (4) and the soil surface of the irrigated farmland is 5-10 cm greater than a maximum tractor-ploughing depth of the irrigated farmland.", "7.The novel pressureless irrigation device according to claim 1, wherein a height adjustment range of the soil saturated water layer is from the bottom of the backfill soil (7) in the soil saturated water layer forming pipe (4) to the top of the soil saturated water layer forming pipe (4) and the height is 3-4 cm lower than the upper edge.", "8.The novel pressureless irrigation device according to claim 5, wherein the height of the soil saturated water layer is controlled and adjusted by controlling and adjusting the water level of the corresponding water supply water level control pool (201) based on the “connector” principle.", "9.The novel pressureless irrigation device according to claim 1, wherein the porous water-permeable plates (5) are sphere-shaped plates having convex surfaces placed upwards." ], [ "<SOH> BACKGROUND <EOH>The concept of pressureless irrigation has been first proposed by an authorized patent “a novel pressureless irrigation device” with a publication number of CN102160518A.", "Pressureless irrigation is an irrigation method in which an elevation of an irrigation water source is equal to that of an irrigator, which is derived from a definition of “negative pressure irrigation”.", "The patent CN102160518A is invented to provide a novel pressureless irrigation device which is as efficient as the negative pressure irrigation, more convenient to use, more durable and highly reliable.", "A patent literature with the publication number of CN102160518A discloses a novel pressureless irrigation device which includes a water supply tank, a water level control pool, a water conveying main pipe, a confluence pipe and a plurality of irrigators (referring to a patent specification of CN102160518A).", "The patent of a novel pressureless irrigation device with the publication number of CN102160518A adopts the irrigator (referring to the patent specification of CN 102160518 A) using a U-shaped concrete trough as a basic structure, and has the following defects.", "Firstly, high-precision concrete pouring molding equipment is required in on-site construction; a series of technical problems exist such as expansion joint anti-seepage treatment and the like; input is large and construction is difficult.", "Secondly, the U-shaped concrete trough made of brittle material is easy to be damaged by frost-heaving, uneven subsidence, tillage machine operation and the like; most importantly, the height of a soil saturated water layer cannot be adjusted for supplying water to a crop root system layer by rising of soil capillary water.", "When water consumption for crop transpiration is not high, and when the soil water continues to rise to a soil surface to form soil evaporation between plants and to cause accumulation of salt in the surface soil, the problem cannot be solved by reducing the height of the soil saturated water layer.", "Similarly, a common problem of irregular seedling emergence caused by inadequate water supply of the surface soil at a seedling stage after underground irrigation sowing also cannot be solved by a method of raising the height of the soil saturated water layer.", "The patent of a novel pressureless irrigation device with the publication number of CN102160518A adopts a water supply tank type water level adjustment and water supply device which has the following defects.", "Firstly, a special control water level adjustment mechanism and control water level gauge are not provided so that the control water level is very difficult to be adjusted accurately, and requirement of accurately and conveniently adjusting the control water level at any time of a novel irrigator of the novel pressureless irrigation device of the present cannot be satisfied.", "Secondly, a water supply tank of the water supply tank type water level adjustment and water supply device needs to operate in a closed state (referring to the patent specification of CN 102160518 A), which cannot be filled with water at any time, and is inconvenient to adopt a photovoltaic water pumping mode." ], [ "<SOH> SUMMARY <EOH>Aims of the present disclosure are to provide a novel pressureless irrigation device capable of overcoming the above defects, to eliminate a problem of irrigator blockage of a “traditional irrigation operation mode” in a brand-new irrigation operation mode, and to realize low-cost and “fool-proof” automatic irrigation and true sense of uniform irrigation.", "The aims of the present disclosure are achieved by follows.", "The novel pressureless irrigation device includes a novel irrigator and a novel water supply system, which uniformly convey irrigation water to crop plant root systems, wherein the novel irrigator and a water supply water level control pool of the novel water supply system are based on a “connector” principle; and the size of a flow cross-section satisfies the extremely-low flowing speed requirement of “lossless conveyance” for the “connector” in a static pressure dominant operating state.", "The novel pressureless irrigation device includes a novel irrigator for the novel pressureless irrigation device, wherein the novel irrigator includes an equal-diameter downstream tee joint, a horizontal water inlet end of the equal-diameter downstream tee joint, a horizontal water outlet end of the equal-diameter downstream tee joint, a vertical water inlet end of the equal-diameter downstream tee joint, a connecting pipe, a reducer pipe, a soil saturated water layer forming pipe, porous water-permeable plates, sandstone inverted filters and backfill soil.", "The equal-diameter downstream tee joint is connected to underground capillary pipes in series.", "The horizontal water inlet end of the equal-diameter downstream tee joint is connected with a head end direction of one capillary pipe.", "The horizontal water outlet end of the equal-diameter downstream tee joint is connected with a rear end direction of the capillary pipe.", "Head ends of all the capillary pipes are communicated with water supply water level control pool by water supply branch pipes and water supply main pipes.", "rear ends of all the capillary pipes are connected with capillary pipe flushing valves by drainage branch pipes and drainage main pipes.", "The water supply branch pipes, the drainage branch pipes, the drainage main pipes and all the capillary pipes are located on a same horizontal plane.", "When noncapillary pipes perform flushing operation, the flushing valves are in a closed state.", "The vertical water inlet end of the equal-diameter downstream tee joint is connected with a small head of the reducer pipe by the connecting pipe.", "A lower end of the soil saturated water layer forming pipe is vertically inserted into a large head of the reducer pipe.", "The porous water-permeable plates are placed at the bottom of the soil saturated water layer forming pipe and on one side of the large head of a diameter reducing position of the reducer pipe.", "The sandstone inverted filters are placed on the porous water-permeable plates.", "The backfill soil is placed on the sandstone inverted filters.", "A distance between a top end of the soil saturated water layer forming pipe and a soil surface of an irrigated farmland is 40-45 cm.", "A height adjustment range of a soil saturated water layer is from the bottom of the backfill soil in the soil saturated water layer forming pipe to the top of the soil saturated water layer forming pipe.", "The height of the soil saturated water layer is adjusted by adjusting a water level of a corresponding water supply water level control pool.", "The novel pressureless irrigation device further includes a floating ball water level control device having a control water level adjustment mechanism and a gauge, wherein water inlet pipes of the water supply water level control pool horizontally penetrate through side walls of the water supply water level control pool from the right to the left and enter the water supply water level control pool.", "Ports connected to an equal-diameter tee face the right.", "A lower end of an upper connecting pipe is connected with the upper port of the equal-diameter tee above ports perpendicular to an upper port and a lower port of the equal-diameter tee.", "An upper end of the upper connecting pipe is connected with the lower end of a female adapter.", "A square plug is mounted at the upper end of the female adapter.", "The upper end of a lower connecting pipe is connected with the lower port of the equal-diameter tee.", "The lower end of the lower connecting pipe is connected with the upper port of a ball valve.", "The lower port of the ball valve is connected with the upper end of a water distribution pipe.", "The water distribution pipe has a suspended lower end and a downward pipe port.", "A horizontal head-on surface of a valve rod of the ball valve is inward, and is perpendicular to a plane on which the upper connecting pipe, the lower connecting pipe and the water inlet pipes in the water supply water level control pool are located, and is perpendicular to the plane.", "A right upper shaft is fixed inwards to the horizontal head-on surface at an upper portion of the upper connecting pipe.", "A right end of the upper connecting rod is sleeved on a right upper shaft after being drilled, and then is equipped with a circular gasket and a gasket fixing plug pin.", "The upper connecting rod can rotate about the shaft in the plane perpendicular to the shaft; the right end of the lower connecting rod is fixed to the valve rod.", "When a left end and a right end of the lower connecting rod are located on the same horizontal plane, the ball valve is in a closed state.", "When the left end of the lower connecting rod is separated from the horizontal plane and moves downwards, the valve rod can be driven to rotate to open the closed ball valve.", "A left lower shaft is fixed inwards parallel to the head-on surface of the valve rod at the lower end of a sleeve.", "The left end of the lower connecting rod is sleeved on the left lower shaft after being drilled and then is equipped with the circular gasket and the gasket fixing plug pin.", "A left upper shaft is fixed inwards and horizontal to the head-on surface and parallel to the right upper shaft on the sleeve at a position with a distance equal to a distance between the valve rod and the right upper shaft above the left lower shaft.", "The left end of the upper connecting rod is sleeved on the left upper shaft after being drilled and then is equipped with the circular gasket and the gasket fixing plug pin.", "The distance between the right upper shaft and the left upper shaft is equal to the distance between the valve rod and the left lower shaft.", "A pull ring is fixed at the upper end of a floating box connecting rod.", "Control level gauges are arranged on the upper portion of the floating box connecting rod and the floating box connecting rod below the pull ring.", "The lower end of the floating box connecting rod penetrating through the sleeve is fixed to a floating box by a fixing nut on the floating box.", "Control water level positioning pins are mounted on an upward extended section of the sleeve and on the sleeve at a height higher than an upper cover plate of the water supply water level control pool and convenient to operate above the left upper shaft.", "The upper connecting rod and the lower connecting rod move in the same plane perpendicular to the valve rod, the right upper shaft, the left lower shaft and the left upper shaft.", "The pipe port at one end of the water outlet pipe of each water supply water level control pool penetrates through the side wall of the water supply water level control pool, and is located at the bottom of the water supply water level control pool, and is 20-25 cm higher than a bottom surface of the water supply water level control pool.", "The other ends of the water outlet pipes of the water supply water level control pool are connected with the water supply main pipes in the novel irrigator for the novel pressureless irrigation device.", "The novel pressureless irrigation device further includes a photovoltaic water supply system for the novel irrigator of the novel pressureless irrigation device.", "The photovoltaic water supply system includes a photovoltaic water pumping portion, a water reservoir and the water supply water level control pool.", "The photovoltaic water pumping portion is composed of a solar battery array, a photovoltaic water pumping invertor and a water pump.", "The solar battery array is placed on the water reservoir.", "The water pump is placed at the bottom in a water source well.", "A water pump water outlet pipe is mounted on a water outlet of the water pump.", "The pipe port at the other end of the water pump water outlet pipe is located above the water reservoir and is downward An overflow pipe is arranged on an upper portion of the water reservoir.", "A water inlet pipe port of the overflow pipe is formed in a side wall of the water reservoir.", "The pipe port is located in the water reservoir and is 10-15 cm lower than an upper edge of the side wall of the water reservoir.", "The other end of the overflow pipe is located outside the water reservoir and has the water outlet pipe port placed in a water source well.", "One end of the water inlet pipe of each water supply water level control pool is connected with the water reservoir.", "The pipe port at the end penetrates through the side wall of the water reservoir, and is located in the water reservoir and is 15-20 cm higher than the bottom surface of the water reservoir.", "The other end of the water inlet pipe of each water supply water level control pool horizontally penetrates through the side wall of the water supply water level control pool from right to left and enters the water supply water level control pool.", "The ports are connected to an equal-diameter tee face the right.", "The lower end of the upper connecting pipe is connected with the upper port of the equal-diameter tee above the ports perpendicular to the upper port and the lower port of the equal-diameter tee.", "The upper end of the upper connecting pipe is connected with the lower end of the female adapter.", "The square plug is mounted at the upper end of the female adapter.", "The upper end of the lower connecting pipe is connected with the lower port of the equal-diameter tee.", "The lower end of the lower connecting pipe is connected with the upper port of the ball valve.", "The lower port of the ball valve is connected with the upper end of the water distribution pipe.", "The water distribution pipe has the suspended lower end and the downward pipe port.", "The horizontal head-on surface of the valve rod of the ball valve is inward, and is perpendicular to the plane on which the upper connecting pipe.", "The lower connecting pipe and the water inlet pipes in the water supply water level control pool are located, and is perpendicular to the plane.", "The right upper shaft is fixed inwards and horizontal to head-on surface at the upper portion of the upper connecting pipe.", "The right end of the upper connecting rod is sleeved on the right upper shaft after being drilled, and then is equipped with the circular gasket and the gasket fixing plug pin.", "The upper connecting rod can rotate about the shaft in the plane perpendicular to the shaft.", "The right end of the lower connecting rod is fixed to the valve rod.", "When the left end and the right end of the lower connecting rod are located on the same horizontal plane, the ball valve is in the closed state.", "When the left end of the lower connecting rod is separated from the horizontal plane and moves downwards, the valve rod can be driven to rotate to open the closed ball valve.", "The left lower shaft is fixed inwards parallel to the head-on surface of the valve rod at the lower end of the sleeve.", "The left end of the lower connecting rod is sleeved on the left lower shaft after being drilled and then is equipped with the circular gasket and the gasket fixing plug pin.", "The left upper shaft is fixed inwards and horizontal to the head-on surface and parallel to the right upper shaft on the sleeve at a position with a distance equal to a distance between the valve rod and the right upper shaft above the left lower shaft.", "The left end of the upper connecting rod is sleeved on the left upper shaft after being drilled and then is equipped with the circular gasket and the gasket fixing plug pin.", "The distance between the right upper shaft and the left upper shaft is equal to the distance between the valve rod and the left lower shaft.", "The pull ring is fixed at the upper end of the floating box connecting rod.", "The control level gauges are arranged on the upper portion of the floating box connecting rod and the floating box connecting rod below the pull ring.", "The lower end of the floating box connecting rod penetrating through the sleeve is fixed to the floating box by the fixing nut on the floating box.", "The control water level positioning pins are mounted on the upward extended section of the sleeve and on the sleeve at the height higher than an upper cover plate of the water supply water level control pool and convenient to operate above the left upper shaft.", "The upper connecting rod and the lower connecting rod move in the same plane perpendicular to the valve rod, the right upper shaft, the left lower shaft and the left upper shaft.", "The pipe port at one end of the water outlet pipe of each water supply water level control pool penetrates through the side wall of the water supply water level control pool, is located in the water supply water level control pool, and is 20-25 cm higher than the bottom surface of the water supply water level control pool.", "The other ends of the water outlet pipes of the water supply water level control pool are connected with the water supply main pipes in the novel irrigator for the novel pressureless irrigation device.", "Further, regarding to the novel pressureless irrigation device, one end of the water inlet pipe of each water supply water level control pool is connected with the water reservoir.", "The water reservoir can supply water in other modes besides the photovoltaic water pumping mode; or the water reservoir and the photovoltaic water pumping portion are replaced with other water sources with a minimum dynamic water level higher than that of the water supply water level control pool.", "Further, regarding to the novel pressureless irrigation device, the novel irrigator and the novel water supply system uniformly convey the irrigation water to the crop plant root systems.", "The novel irrigator and the water supply water level control pool of the novel water supply system are based on the “connector” principle.", "The size of the flow cross-section satisfies the extremely-low flowing speed requirement of “lossless conveyance” for the “connector” in the static pressure dominant operating state.", "Further, regarding to the novel pressureless irrigation device, the distance between the top end of the soil saturated water layer forming pipe and the soil surface of the irrigated farmland is 5-10 cm greater than a maximum tractor-ploughing depth of the irrigated farmland.", "Further, regarding to the novel pressureless irrigation device, the height adjustment range of the soil saturated water layer is from the bottom of the backfill soil in the soil saturated water layer forming pipe to the top of the soil saturated water layer forming pipe and is 3-4 cm lower than the upper edge.", "Further, regarding to the novel pressureless irrigation device, the height of the soil saturated water layer is controlled and adjusted by controlling and adjusting the water level of the corresponding water supply water level control pool based on the “connector” principle.", "Further, regarding to the novel pressureless irrigation device, the porous water-permeable plates are sphere-shaped plates having convex surfaces placed upwards.", "The present disclosure has the following technical features and positive effects.", "For a long time, in order to uniformly convey the irrigation water to the crop plant root systems, an irrigation operation mode of dissipating energy is realized via the irrigator after pressurization, referred to as a “traditional irrigation operation mode” in the present description.", "Theoretically, in the “traditional irrigation operation mode”, the irrigator blockage takes place along with energy dissipation of the irrigator.", "The energy dissipation of the irrigator provides conditions for the irrigator blockage.", "The irrigator blockage is difficult to be eliminated as long as the irrigator still can perform an energy dissipation function.", "Long-term scientific research and production practice also prove that elimination of the irrigator blockage under the “traditional irrigation operation mode” with a premise, such as an environment-friendly non-chemical method, which seems to be an impossible task, and deserves a name of worldwide problem.", "The novel pressureless irrigation device of the present disclosure uniformly conveys the irrigation water to the crop plant root systems on the basis of the “connector” principle.", "The novel pressureless irrigation device of the present disclosure does not need to pressurize, and adopts “lossless conveyance”, with a driving force from a capillary force of the soil and a water potential energy difference of the soil, the plants and the atmosphere which consume solar energy.", "It is a brand-new irrigation operation mode substantially different from the “traditional irrigation operation mode”, and has a necessary and sufficient condition of the “lossless conveyance” in the static pressure dominant operating state based on the “connector” principle.", "Because of soil capillary force as well as the water potential energy difference between the soil, the plants and the atmosphere, the water of the soil saturated water layer in the soil saturated water layer forming pipe rises to a crop plant system layer in a form of soil capillary water, and then is conveyed to the atmosphere via transpiration of the crop plant.", "The transpiration of the crop plant consumes the water of the soil saturated water layer in the soil saturated water layer forming pipe, so that the height of the soil saturated water layer in the soil saturated water layer forming pipe falls.", "On the basis of the “connector” principle, the water supply water level control pool at a head portion is triggered to replenish the water.", "The replenished water is as much as the water consumed by crops.", "The volume of replenished water is increased or reduced with water consumption adaptively without human intervention and additional energy, so that low-cost and “fool-proof” automatic irrigation and true sense of uniform irrigation are realized.", "For the “traditional irrigation operation mode”, the irrigation quantity is set artificially.", "The soil is irrigated with the same volume of water without considering spatial difference of own water conditions of the soil.", "In fact, the volume of water may be appropriate for one portion of a field and may be excessive or insufficient to the other portion, thereby affecting the growth of the crops.", "In other words, in the “traditional irrigation operation mode”, even if the volume of water flowing from each irrigator is identical, it is not uniform irrigation in true sense.", "Following the “connector” principle, only when the size of the flow cross-section necessarily satisfies the extremely-low flowing speed requirement of “lossless conveyance” for the “connector” in the static pressure dominant operating state, the irrigation water can be uniformly conveyed to the crop plant root systems.", "Otherwise, the greater the distance from the water supply water level control pool at the head portion is, the lower the height of the soil saturated water layer in the soil saturated water layer forming pipe is.", "The purpose of uniformly conveying the irrigation water to the crop plant root systems cannot be achieved.", "The so-called “lossless conveyance” refers to “lossless conveyance” with relative significance when the height of the soil saturated water layer in the soil saturated water layer forming pipe at a maximum distance from the water supply water level control pool at the head portion falls due to conveyance loss, the water supply uniformity and costs are taken into account, and the maximum falling magnitude (appearing at a maximum replenished water flow corresponding to the maximum water consumption) is in an allowable range.", "The “lossless conveyance” can be realized only when an area of the flow cross-section is increased and an on-way resistance of conveyance is reduced in a manner of reducing the flow speed, i.e., the so-called the extremely-low flowing speed requirement of “lossless conveyance” for the “connector” in the static pressure dominant operating state.", "Certainly, the area of a soil pore channel is increased by increasing a pipe diameter of the soil saturated water layer forming pipe of the novel irrigator.", "The pipe diameter of the soil saturated water layer forming pipe must be greater than that of the capillary pipe at the same flow and flow speed.", "Because of “adaptive irrigation”, the water is saved to the largest degree.", "The conveyed flow rate is far less than that in the “traditional irrigation operation mode”.", "The investment of the area of the flow cross-section increased to satisfy the extremely-low flowing speed requirement of “lossless conveyance” for the “connector” in the static pressure dominant operating state of the “connector” is not great.", "Compared with the “traditional irrigation operation mode”, the adaptive irrigation is cost-effective, economical and completely acceptable.", "Specific pipes and sizes used by the flow cross-section are shown in embodiments of the novel irrigator of the present disclosure.", "Certainly, when the extremely-low flowing speed requirement with “lossless conveyance” for the “connector” in the static pressure dominant operating state is satisfied, other combinations of the pipes and the sizes except embodiments of the novel irrigator of the present disclosure can also be adopted as required.", "For example, based on an actual situation that the on-way water flow rate of the capillary pipes is gradually reduced, the on-way reducing thick-to-fine capillary pipes are adopted to achieve the purpose of being more economical and enhancing the flushing effect of the capillary pipes (the capillary pipe flushing valves are opened).", "The extremely-low flowing speed greatly weakens the entrainment capability to solid particles in the irrigation water, and in combination with a precipitation effect of gravity, the solid particles in the irrigation water cannot be moved to the soil pore channel of the soil saturated water layer forming pipe located at a high altitude to form blockage, thereby eliminating a root cause of the irrigator blockage.", "Therefore, an excellent anti-blockage performance is realized without any filtering device.", "The solid particles precipitated in the capillary pipes located at a low altitude can be flushed out by opening the capillary pipe flushing valves.", "Because we irrigate non-aquatic crops, a situation that the crop root systems invade into the soil saturated water layer forming pipe does not appear.", "Even if invasion exists, the soil saturated water layer forming pipe with a large pipe diameter cannot be blocked, thereby eliminating the problem of irrigator blockage when the irrigator performs the energy dissipation function in the “traditional irrigation operation mode”.", "According to a fundamental law of fluid mechanics, the resistance (water head loss) is in direct proportion to the square of the flow speed.", "The flow speed is very low and almost no conveyance loss exists, so that the volume of supplied water is large and the water supply is sufficient, and thus the volume of an unsaturated wetting body in the soil formed under action of the capillary pipes of the soil is maximum and the irrigators can be laid under a tractor-ploughing layer slightly farther from the crop plant root systems, thereby overcoming major defects that the other “adaptive irrigation” method-“negative pressure irrigation” cannot satisfy water demands of the crops when the conveying resistance (stroke) of the soil is increased since the driving force is excessively consumed when resisting the conveying resistance of the “negative pressure irrigation” system, causing that the irrigators for the “negative pressure irrigation” cannot be laid under the tractor-ploughing layer slightly farther from the crop plant root systems, thereby affecting the tractor-ploughing operation and requiring frequently laying the underground irrigators and the capillary pipes for the “negative pressure irrigation”.", "The novel pressureless irrigation device of the present disclosure is sturdy and durable and can accurately adjust the control water level of the underground water supply water level control pool by the over ground control water level gauge and positioning pin.", "The height of the soil saturated water layer for supplying water to the crop root system layer by raising the water in the soil capillary pipe can be controlled and adjusted conveniently and accurately since the “lossless conveyance” based on the “connector” principle does not consume the driving force, a spared space for controlling and adjusting the height of the soil saturated water layer is large enough, and an optimum strategy for controlling and adjusting the height of the soil saturated water layer for supplying water to the crop root system layer by raising the water in the soil capillary pipe still can be adopted in the case of shallow or deep crop root systems, high or low water consumption and the like in different growth periods of the crops when the irrigators are laid under the tractor-ploughing layer.", "For example, the height of the soil saturated water layer is reduced to avoid the occurrence of accumulation of salt in the surface soil when the water consumption for crop transpiration is not high and the soil water continues to rise to the soil surface to form soil evaporation between plants.", "For another example, the height of the soil saturated water layer is increased to avoid affecting seedling emergence and the like since the water supply of the surface soil is insufficient at a seedling stage after sowing, so that the crops are always in an optimum (for example, when evaporation exists between the plants, the height of the soil saturated water layer is reduced) or not the optimum but the most reasonable (for example, the height of the soil saturated water layer is increased at the seedling stage after sowing) irrigation state.", "In the present disclosure, the water is supplied upwards in an infiltration manner based on the “connector” principle, so that the soil is loose and not hardened.", "The higher the soil is, the lower the wetting degree is.", "The evaporation of the upper soil is less, and the growth of weeds can be effectively inhibited.", "The “lossless conveyance” based on the “connector” principle almost has no water supply resistance, so that the volume of the unsaturated wetting body in the soil formed under action of the soil capillary pipe is maximum.", "Compared with the other “adaptive irrigation” method-“negative pressure irrigation” which has large water supply resistance and too small soil wetting range, when the same irrigation uniformity is achieved, a distribution density of the irrigators can be reduced, and a line spacing is increased to reduce the investment and achieve ideal effects of large volume of supplied water, sufficient water supply, no deep seepage and the irrigators being optimally deeply buried under the tractor-ploughing layer.", "The wide wetting range in the soil is further beneficial for uniform distribution of water and fertilizer, which can create greater growth space for the root systems, and reduces salt damage.", "A non-intermittent continuous irrigation mode of the present disclosure based on the “connector” principle enables the size of the soil wetting body and a water and fertilizer distribution gradient to be relatively stable, and is beneficial for the plant root systems to grow to an optimum soil water and fertilizer position, and gives full play to an optimum physiological regulation function of the plant root systems so that the root system layer cannot be subjected to soil water saturation due to irrigation, sequentially reduces the humidity of the soil from bottom to top.", "So that the air permeability of the soil is the best and the temperature is risen rapidly.", "It is not only superior to the intermittent ground water supply irrigation capable of forming a soil water saturation situation on the upper layers of the root systems, but also superior to various positive pressure difference irrigations capable of directly supplying water to partial crop root systems partially forming the soil water saturation situation on the root system layer, and has a crop growth environment, i.e., water and fertilizer gas-heating conditions, better than any one of previous irrigation modes and methods." ], [ "TECHNICAL FIELD The present disclosure belongs to the technical field of farmland irrigation, and particularly relates to a novel pressureless irrigation device.", "BACKGROUND The concept of pressureless irrigation has been first proposed by an authorized patent “a novel pressureless irrigation device” with a publication number of CN102160518A.", "Pressureless irrigation is an irrigation method in which an elevation of an irrigation water source is equal to that of an irrigator, which is derived from a definition of “negative pressure irrigation”.", "The patent CN102160518A is invented to provide a novel pressureless irrigation device which is as efficient as the negative pressure irrigation, more convenient to use, more durable and highly reliable.", "A patent literature with the publication number of CN102160518A discloses a novel pressureless irrigation device which includes a water supply tank, a water level control pool, a water conveying main pipe, a confluence pipe and a plurality of irrigators (referring to a patent specification of CN102160518A).", "The patent of a novel pressureless irrigation device with the publication number of CN102160518A adopts the irrigator (referring to the patent specification of CN 102160518 A) using a U-shaped concrete trough as a basic structure, and has the following defects.", "Firstly, high-precision concrete pouring molding equipment is required in on-site construction; a series of technical problems exist such as expansion joint anti-seepage treatment and the like; input is large and construction is difficult.", "Secondly, the U-shaped concrete trough made of brittle material is easy to be damaged by frost-heaving, uneven subsidence, tillage machine operation and the like; most importantly, the height of a soil saturated water layer cannot be adjusted for supplying water to a crop root system layer by rising of soil capillary water.", "When water consumption for crop transpiration is not high, and when the soil water continues to rise to a soil surface to form soil evaporation between plants and to cause accumulation of salt in the surface soil, the problem cannot be solved by reducing the height of the soil saturated water layer.", "Similarly, a common problem of irregular seedling emergence caused by inadequate water supply of the surface soil at a seedling stage after underground irrigation sowing also cannot be solved by a method of raising the height of the soil saturated water layer.", "The patent of a novel pressureless irrigation device with the publication number of CN102160518A adopts a water supply tank type water level adjustment and water supply device which has the following defects.", "Firstly, a special control water level adjustment mechanism and control water level gauge are not provided so that the control water level is very difficult to be adjusted accurately, and requirement of accurately and conveniently adjusting the control water level at any time of a novel irrigator of the novel pressureless irrigation device of the present cannot be satisfied.", "Secondly, a water supply tank of the water supply tank type water level adjustment and water supply device needs to operate in a closed state (referring to the patent specification of CN 102160518 A), which cannot be filled with water at any time, and is inconvenient to adopt a photovoltaic water pumping mode.", "SUMMARY Aims of the present disclosure are to provide a novel pressureless irrigation device capable of overcoming the above defects, to eliminate a problem of irrigator blockage of a “traditional irrigation operation mode” in a brand-new irrigation operation mode, and to realize low-cost and “fool-proof” automatic irrigation and true sense of uniform irrigation.", "The aims of the present disclosure are achieved by follows.", "The novel pressureless irrigation device includes a novel irrigator and a novel water supply system, which uniformly convey irrigation water to crop plant root systems, wherein the novel irrigator and a water supply water level control pool of the novel water supply system are based on a “connector” principle; and the size of a flow cross-section satisfies the extremely-low flowing speed requirement of “lossless conveyance” for the “connector” in a static pressure dominant operating state.", "The novel pressureless irrigation device includes a novel irrigator for the novel pressureless irrigation device, wherein the novel irrigator includes an equal-diameter downstream tee joint, a horizontal water inlet end of the equal-diameter downstream tee joint, a horizontal water outlet end of the equal-diameter downstream tee joint, a vertical water inlet end of the equal-diameter downstream tee joint, a connecting pipe, a reducer pipe, a soil saturated water layer forming pipe, porous water-permeable plates, sandstone inverted filters and backfill soil.", "The equal-diameter downstream tee joint is connected to underground capillary pipes in series.", "The horizontal water inlet end of the equal-diameter downstream tee joint is connected with a head end direction of one capillary pipe.", "The horizontal water outlet end of the equal-diameter downstream tee joint is connected with a rear end direction of the capillary pipe.", "Head ends of all the capillary pipes are communicated with water supply water level control pool by water supply branch pipes and water supply main pipes.", "rear ends of all the capillary pipes are connected with capillary pipe flushing valves by drainage branch pipes and drainage main pipes.", "The water supply branch pipes, the drainage branch pipes, the drainage main pipes and all the capillary pipes are located on a same horizontal plane.", "When noncapillary pipes perform flushing operation, the flushing valves are in a closed state.", "The vertical water inlet end of the equal-diameter downstream tee joint is connected with a small head of the reducer pipe by the connecting pipe.", "A lower end of the soil saturated water layer forming pipe is vertically inserted into a large head of the reducer pipe.", "The porous water-permeable plates are placed at the bottom of the soil saturated water layer forming pipe and on one side of the large head of a diameter reducing position of the reducer pipe.", "The sandstone inverted filters are placed on the porous water-permeable plates.", "The backfill soil is placed on the sandstone inverted filters.", "A distance between a top end of the soil saturated water layer forming pipe and a soil surface of an irrigated farmland is 40-45 cm.", "A height adjustment range of a soil saturated water layer is from the bottom of the backfill soil in the soil saturated water layer forming pipe to the top of the soil saturated water layer forming pipe.", "The height of the soil saturated water layer is adjusted by adjusting a water level of a corresponding water supply water level control pool.", "The novel pressureless irrigation device further includes a floating ball water level control device having a control water level adjustment mechanism and a gauge, wherein water inlet pipes of the water supply water level control pool horizontally penetrate through side walls of the water supply water level control pool from the right to the left and enter the water supply water level control pool.", "Ports connected to an equal-diameter tee face the right.", "A lower end of an upper connecting pipe is connected with the upper port of the equal-diameter tee above ports perpendicular to an upper port and a lower port of the equal-diameter tee.", "An upper end of the upper connecting pipe is connected with the lower end of a female adapter.", "A square plug is mounted at the upper end of the female adapter.", "The upper end of a lower connecting pipe is connected with the lower port of the equal-diameter tee.", "The lower end of the lower connecting pipe is connected with the upper port of a ball valve.", "The lower port of the ball valve is connected with the upper end of a water distribution pipe.", "The water distribution pipe has a suspended lower end and a downward pipe port.", "A horizontal head-on surface of a valve rod of the ball valve is inward, and is perpendicular to a plane on which the upper connecting pipe, the lower connecting pipe and the water inlet pipes in the water supply water level control pool are located, and is perpendicular to the plane.", "A right upper shaft is fixed inwards to the horizontal head-on surface at an upper portion of the upper connecting pipe.", "A right end of the upper connecting rod is sleeved on a right upper shaft after being drilled, and then is equipped with a circular gasket and a gasket fixing plug pin.", "The upper connecting rod can rotate about the shaft in the plane perpendicular to the shaft; the right end of the lower connecting rod is fixed to the valve rod.", "When a left end and a right end of the lower connecting rod are located on the same horizontal plane, the ball valve is in a closed state.", "When the left end of the lower connecting rod is separated from the horizontal plane and moves downwards, the valve rod can be driven to rotate to open the closed ball valve.", "A left lower shaft is fixed inwards parallel to the head-on surface of the valve rod at the lower end of a sleeve.", "The left end of the lower connecting rod is sleeved on the left lower shaft after being drilled and then is equipped with the circular gasket and the gasket fixing plug pin.", "A left upper shaft is fixed inwards and horizontal to the head-on surface and parallel to the right upper shaft on the sleeve at a position with a distance equal to a distance between the valve rod and the right upper shaft above the left lower shaft.", "The left end of the upper connecting rod is sleeved on the left upper shaft after being drilled and then is equipped with the circular gasket and the gasket fixing plug pin.", "The distance between the right upper shaft and the left upper shaft is equal to the distance between the valve rod and the left lower shaft.", "A pull ring is fixed at the upper end of a floating box connecting rod.", "Control level gauges are arranged on the upper portion of the floating box connecting rod and the floating box connecting rod below the pull ring.", "The lower end of the floating box connecting rod penetrating through the sleeve is fixed to a floating box by a fixing nut on the floating box.", "Control water level positioning pins are mounted on an upward extended section of the sleeve and on the sleeve at a height higher than an upper cover plate of the water supply water level control pool and convenient to operate above the left upper shaft.", "The upper connecting rod and the lower connecting rod move in the same plane perpendicular to the valve rod, the right upper shaft, the left lower shaft and the left upper shaft.", "The pipe port at one end of the water outlet pipe of each water supply water level control pool penetrates through the side wall of the water supply water level control pool, and is located at the bottom of the water supply water level control pool, and is 20-25 cm higher than a bottom surface of the water supply water level control pool.", "The other ends of the water outlet pipes of the water supply water level control pool are connected with the water supply main pipes in the novel irrigator for the novel pressureless irrigation device.", "The novel pressureless irrigation device further includes a photovoltaic water supply system for the novel irrigator of the novel pressureless irrigation device.", "The photovoltaic water supply system includes a photovoltaic water pumping portion, a water reservoir and the water supply water level control pool.", "The photovoltaic water pumping portion is composed of a solar battery array, a photovoltaic water pumping invertor and a water pump.", "The solar battery array is placed on the water reservoir.", "The water pump is placed at the bottom in a water source well.", "A water pump water outlet pipe is mounted on a water outlet of the water pump.", "The pipe port at the other end of the water pump water outlet pipe is located above the water reservoir and is downward An overflow pipe is arranged on an upper portion of the water reservoir.", "A water inlet pipe port of the overflow pipe is formed in a side wall of the water reservoir.", "The pipe port is located in the water reservoir and is 10-15 cm lower than an upper edge of the side wall of the water reservoir.", "The other end of the overflow pipe is located outside the water reservoir and has the water outlet pipe port placed in a water source well.", "One end of the water inlet pipe of each water supply water level control pool is connected with the water reservoir.", "The pipe port at the end penetrates through the side wall of the water reservoir, and is located in the water reservoir and is 15-20 cm higher than the bottom surface of the water reservoir.", "The other end of the water inlet pipe of each water supply water level control pool horizontally penetrates through the side wall of the water supply water level control pool from right to left and enters the water supply water level control pool.", "The ports are connected to an equal-diameter tee face the right.", "The lower end of the upper connecting pipe is connected with the upper port of the equal-diameter tee above the ports perpendicular to the upper port and the lower port of the equal-diameter tee.", "The upper end of the upper connecting pipe is connected with the lower end of the female adapter.", "The square plug is mounted at the upper end of the female adapter.", "The upper end of the lower connecting pipe is connected with the lower port of the equal-diameter tee.", "The lower end of the lower connecting pipe is connected with the upper port of the ball valve.", "The lower port of the ball valve is connected with the upper end of the water distribution pipe.", "The water distribution pipe has the suspended lower end and the downward pipe port.", "The horizontal head-on surface of the valve rod of the ball valve is inward, and is perpendicular to the plane on which the upper connecting pipe.", "The lower connecting pipe and the water inlet pipes in the water supply water level control pool are located, and is perpendicular to the plane.", "The right upper shaft is fixed inwards and horizontal to head-on surface at the upper portion of the upper connecting pipe.", "The right end of the upper connecting rod is sleeved on the right upper shaft after being drilled, and then is equipped with the circular gasket and the gasket fixing plug pin.", "The upper connecting rod can rotate about the shaft in the plane perpendicular to the shaft.", "The right end of the lower connecting rod is fixed to the valve rod.", "When the left end and the right end of the lower connecting rod are located on the same horizontal plane, the ball valve is in the closed state.", "When the left end of the lower connecting rod is separated from the horizontal plane and moves downwards, the valve rod can be driven to rotate to open the closed ball valve.", "The left lower shaft is fixed inwards parallel to the head-on surface of the valve rod at the lower end of the sleeve.", "The left end of the lower connecting rod is sleeved on the left lower shaft after being drilled and then is equipped with the circular gasket and the gasket fixing plug pin.", "The left upper shaft is fixed inwards and horizontal to the head-on surface and parallel to the right upper shaft on the sleeve at a position with a distance equal to a distance between the valve rod and the right upper shaft above the left lower shaft.", "The left end of the upper connecting rod is sleeved on the left upper shaft after being drilled and then is equipped with the circular gasket and the gasket fixing plug pin.", "The distance between the right upper shaft and the left upper shaft is equal to the distance between the valve rod and the left lower shaft.", "The pull ring is fixed at the upper end of the floating box connecting rod.", "The control level gauges are arranged on the upper portion of the floating box connecting rod and the floating box connecting rod below the pull ring.", "The lower end of the floating box connecting rod penetrating through the sleeve is fixed to the floating box by the fixing nut on the floating box.", "The control water level positioning pins are mounted on the upward extended section of the sleeve and on the sleeve at the height higher than an upper cover plate of the water supply water level control pool and convenient to operate above the left upper shaft.", "The upper connecting rod and the lower connecting rod move in the same plane perpendicular to the valve rod, the right upper shaft, the left lower shaft and the left upper shaft.", "The pipe port at one end of the water outlet pipe of each water supply water level control pool penetrates through the side wall of the water supply water level control pool, is located in the water supply water level control pool, and is 20-25 cm higher than the bottom surface of the water supply water level control pool.", "The other ends of the water outlet pipes of the water supply water level control pool are connected with the water supply main pipes in the novel irrigator for the novel pressureless irrigation device.", "Further, regarding to the novel pressureless irrigation device, one end of the water inlet pipe of each water supply water level control pool is connected with the water reservoir.", "The water reservoir can supply water in other modes besides the photovoltaic water pumping mode; or the water reservoir and the photovoltaic water pumping portion are replaced with other water sources with a minimum dynamic water level higher than that of the water supply water level control pool.", "Further, regarding to the novel pressureless irrigation device, the novel irrigator and the novel water supply system uniformly convey the irrigation water to the crop plant root systems.", "The novel irrigator and the water supply water level control pool of the novel water supply system are based on the “connector” principle.", "The size of the flow cross-section satisfies the extremely-low flowing speed requirement of “lossless conveyance” for the “connector” in the static pressure dominant operating state.", "Further, regarding to the novel pressureless irrigation device, the distance between the top end of the soil saturated water layer forming pipe and the soil surface of the irrigated farmland is 5-10 cm greater than a maximum tractor-ploughing depth of the irrigated farmland.", "Further, regarding to the novel pressureless irrigation device, the height adjustment range of the soil saturated water layer is from the bottom of the backfill soil in the soil saturated water layer forming pipe to the top of the soil saturated water layer forming pipe and is 3-4 cm lower than the upper edge.", "Further, regarding to the novel pressureless irrigation device, the height of the soil saturated water layer is controlled and adjusted by controlling and adjusting the water level of the corresponding water supply water level control pool based on the “connector” principle.", "Further, regarding to the novel pressureless irrigation device, the porous water-permeable plates are sphere-shaped plates having convex surfaces placed upwards.", "The present disclosure has the following technical features and positive effects.", "For a long time, in order to uniformly convey the irrigation water to the crop plant root systems, an irrigation operation mode of dissipating energy is realized via the irrigator after pressurization, referred to as a “traditional irrigation operation mode” in the present description.", "Theoretically, in the “traditional irrigation operation mode”, the irrigator blockage takes place along with energy dissipation of the irrigator.", "The energy dissipation of the irrigator provides conditions for the irrigator blockage.", "The irrigator blockage is difficult to be eliminated as long as the irrigator still can perform an energy dissipation function.", "Long-term scientific research and production practice also prove that elimination of the irrigator blockage under the “traditional irrigation operation mode” with a premise, such as an environment-friendly non-chemical method, which seems to be an impossible task, and deserves a name of worldwide problem.", "The novel pressureless irrigation device of the present disclosure uniformly conveys the irrigation water to the crop plant root systems on the basis of the “connector” principle.", "The novel pressureless irrigation device of the present disclosure does not need to pressurize, and adopts “lossless conveyance”, with a driving force from a capillary force of the soil and a water potential energy difference of the soil, the plants and the atmosphere which consume solar energy.", "It is a brand-new irrigation operation mode substantially different from the “traditional irrigation operation mode”, and has a necessary and sufficient condition of the “lossless conveyance” in the static pressure dominant operating state based on the “connector” principle.", "Because of soil capillary force as well as the water potential energy difference between the soil, the plants and the atmosphere, the water of the soil saturated water layer in the soil saturated water layer forming pipe rises to a crop plant system layer in a form of soil capillary water, and then is conveyed to the atmosphere via transpiration of the crop plant.", "The transpiration of the crop plant consumes the water of the soil saturated water layer in the soil saturated water layer forming pipe, so that the height of the soil saturated water layer in the soil saturated water layer forming pipe falls.", "On the basis of the “connector” principle, the water supply water level control pool at a head portion is triggered to replenish the water.", "The replenished water is as much as the water consumed by crops.", "The volume of replenished water is increased or reduced with water consumption adaptively without human intervention and additional energy, so that low-cost and “fool-proof” automatic irrigation and true sense of uniform irrigation are realized.", "For the “traditional irrigation operation mode”, the irrigation quantity is set artificially.", "The soil is irrigated with the same volume of water without considering spatial difference of own water conditions of the soil.", "In fact, the volume of water may be appropriate for one portion of a field and may be excessive or insufficient to the other portion, thereby affecting the growth of the crops.", "In other words, in the “traditional irrigation operation mode”, even if the volume of water flowing from each irrigator is identical, it is not uniform irrigation in true sense.", "Following the “connector” principle, only when the size of the flow cross-section necessarily satisfies the extremely-low flowing speed requirement of “lossless conveyance” for the “connector” in the static pressure dominant operating state, the irrigation water can be uniformly conveyed to the crop plant root systems.", "Otherwise, the greater the distance from the water supply water level control pool at the head portion is, the lower the height of the soil saturated water layer in the soil saturated water layer forming pipe is.", "The purpose of uniformly conveying the irrigation water to the crop plant root systems cannot be achieved.", "The so-called “lossless conveyance” refers to “lossless conveyance” with relative significance when the height of the soil saturated water layer in the soil saturated water layer forming pipe at a maximum distance from the water supply water level control pool at the head portion falls due to conveyance loss, the water supply uniformity and costs are taken into account, and the maximum falling magnitude (appearing at a maximum replenished water flow corresponding to the maximum water consumption) is in an allowable range.", "The “lossless conveyance” can be realized only when an area of the flow cross-section is increased and an on-way resistance of conveyance is reduced in a manner of reducing the flow speed, i.e., the so-called the extremely-low flowing speed requirement of “lossless conveyance” for the “connector” in the static pressure dominant operating state.", "Certainly, the area of a soil pore channel is increased by increasing a pipe diameter of the soil saturated water layer forming pipe of the novel irrigator.", "The pipe diameter of the soil saturated water layer forming pipe must be greater than that of the capillary pipe at the same flow and flow speed.", "Because of “adaptive irrigation”, the water is saved to the largest degree.", "The conveyed flow rate is far less than that in the “traditional irrigation operation mode”.", "The investment of the area of the flow cross-section increased to satisfy the extremely-low flowing speed requirement of “lossless conveyance” for the “connector” in the static pressure dominant operating state of the “connector” is not great.", "Compared with the “traditional irrigation operation mode”, the adaptive irrigation is cost-effective, economical and completely acceptable.", "Specific pipes and sizes used by the flow cross-section are shown in embodiments of the novel irrigator of the present disclosure.", "Certainly, when the extremely-low flowing speed requirement with “lossless conveyance” for the “connector” in the static pressure dominant operating state is satisfied, other combinations of the pipes and the sizes except embodiments of the novel irrigator of the present disclosure can also be adopted as required.", "For example, based on an actual situation that the on-way water flow rate of the capillary pipes is gradually reduced, the on-way reducing thick-to-fine capillary pipes are adopted to achieve the purpose of being more economical and enhancing the flushing effect of the capillary pipes (the capillary pipe flushing valves are opened).", "The extremely-low flowing speed greatly weakens the entrainment capability to solid particles in the irrigation water, and in combination with a precipitation effect of gravity, the solid particles in the irrigation water cannot be moved to the soil pore channel of the soil saturated water layer forming pipe located at a high altitude to form blockage, thereby eliminating a root cause of the irrigator blockage.", "Therefore, an excellent anti-blockage performance is realized without any filtering device.", "The solid particles precipitated in the capillary pipes located at a low altitude can be flushed out by opening the capillary pipe flushing valves.", "Because we irrigate non-aquatic crops, a situation that the crop root systems invade into the soil saturated water layer forming pipe does not appear.", "Even if invasion exists, the soil saturated water layer forming pipe with a large pipe diameter cannot be blocked, thereby eliminating the problem of irrigator blockage when the irrigator performs the energy dissipation function in the “traditional irrigation operation mode”.", "According to a fundamental law of fluid mechanics, the resistance (water head loss) is in direct proportion to the square of the flow speed.", "The flow speed is very low and almost no conveyance loss exists, so that the volume of supplied water is large and the water supply is sufficient, and thus the volume of an unsaturated wetting body in the soil formed under action of the capillary pipes of the soil is maximum and the irrigators can be laid under a tractor-ploughing layer slightly farther from the crop plant root systems, thereby overcoming major defects that the other “adaptive irrigation” method-“negative pressure irrigation” cannot satisfy water demands of the crops when the conveying resistance (stroke) of the soil is increased since the driving force is excessively consumed when resisting the conveying resistance of the “negative pressure irrigation” system, causing that the irrigators for the “negative pressure irrigation” cannot be laid under the tractor-ploughing layer slightly farther from the crop plant root systems, thereby affecting the tractor-ploughing operation and requiring frequently laying the underground irrigators and the capillary pipes for the “negative pressure irrigation”.", "The novel pressureless irrigation device of the present disclosure is sturdy and durable and can accurately adjust the control water level of the underground water supply water level control pool by the over ground control water level gauge and positioning pin.", "The height of the soil saturated water layer for supplying water to the crop root system layer by raising the water in the soil capillary pipe can be controlled and adjusted conveniently and accurately since the “lossless conveyance” based on the “connector” principle does not consume the driving force, a spared space for controlling and adjusting the height of the soil saturated water layer is large enough, and an optimum strategy for controlling and adjusting the height of the soil saturated water layer for supplying water to the crop root system layer by raising the water in the soil capillary pipe still can be adopted in the case of shallow or deep crop root systems, high or low water consumption and the like in different growth periods of the crops when the irrigators are laid under the tractor-ploughing layer.", "For example, the height of the soil saturated water layer is reduced to avoid the occurrence of accumulation of salt in the surface soil when the water consumption for crop transpiration is not high and the soil water continues to rise to the soil surface to form soil evaporation between plants.", "For another example, the height of the soil saturated water layer is increased to avoid affecting seedling emergence and the like since the water supply of the surface soil is insufficient at a seedling stage after sowing, so that the crops are always in an optimum (for example, when evaporation exists between the plants, the height of the soil saturated water layer is reduced) or not the optimum but the most reasonable (for example, the height of the soil saturated water layer is increased at the seedling stage after sowing) irrigation state.", "In the present disclosure, the water is supplied upwards in an infiltration manner based on the “connector” principle, so that the soil is loose and not hardened.", "The higher the soil is, the lower the wetting degree is.", "The evaporation of the upper soil is less, and the growth of weeds can be effectively inhibited.", "The “lossless conveyance” based on the “connector” principle almost has no water supply resistance, so that the volume of the unsaturated wetting body in the soil formed under action of the soil capillary pipe is maximum.", "Compared with the other “adaptive irrigation” method-“negative pressure irrigation” which has large water supply resistance and too small soil wetting range, when the same irrigation uniformity is achieved, a distribution density of the irrigators can be reduced, and a line spacing is increased to reduce the investment and achieve ideal effects of large volume of supplied water, sufficient water supply, no deep seepage and the irrigators being optimally deeply buried under the tractor-ploughing layer.", "The wide wetting range in the soil is further beneficial for uniform distribution of water and fertilizer, which can create greater growth space for the root systems, and reduces salt damage.", "A non-intermittent continuous irrigation mode of the present disclosure based on the “connector” principle enables the size of the soil wetting body and a water and fertilizer distribution gradient to be relatively stable, and is beneficial for the plant root systems to grow to an optimum soil water and fertilizer position, and gives full play to an optimum physiological regulation function of the plant root systems so that the root system layer cannot be subjected to soil water saturation due to irrigation, sequentially reduces the humidity of the soil from bottom to top.", "So that the air permeability of the soil is the best and the temperature is risen rapidly.", "It is not only superior to the intermittent ground water supply irrigation capable of forming a soil water saturation situation on the upper layers of the root systems, but also superior to various positive pressure difference irrigations capable of directly supplying water to partial crop root systems partially forming the soil water saturation situation on the root system layer, and has a crop growth environment, i.e., water and fertilizer gas-heating conditions, better than any one of previous irrigation modes and methods.", "BRIEF DESCRIPTION OF THE DRAWINGS The above and other features, natures and advantages of the present disclosure become apparent with descriptions to drawings and embodiments below, wherein FIG.", "1 is a schematic diagram of a novel irrigator of a novel pressureless irrigation device of the present disclosure.", "FIG.", "2 is a schematic diagram of a water level control pool for water supply of a novel water supply system of a novel pressureless irrigation device of the present disclosure.", "DETAILED DESCRIPTION OF THE DISCLOSURE The present disclosure is further described below with specific embodiments and drawings.", "More derears are illustrated in the following descriptions in order to fully understand the present disclosure.", "However, the present disclosure can be apparently implemented in many other manners different from those described herein.", "Those skilled in the art can make similar promotions and deductions according to actual application situations without departing from connotations of the present disclosure.", "Therefore, a protection scope of the present disclosure should not be limited by contents of the specific embodiments.", "It should be noted that FIG.", "1 to FIG.", "2 are only taken as examples, and are not drawn at an equal proportion, and should not be used for limiting the protection scope actually demanded by the present disclosure.", "The novel pressureless irrigation device includes a novel irrigator and a novel water supply system, which uniformly convey irrigation water to crop plant root systems, wherein the novel irrigator and a water supply water level control pool 201 of the novel water supply system are based on a “connector” principle; and the size of a flow cross-section satisfies very extremely-low flowing speed requirement of “lossless conveyance” for the “connector” in a static pressure dominant operating state.", "As shown in FIG.", "1, the novel pressureless irrigation device includes a novel irrigator for the novel pressureless irrigation device, wherein the novel irrigator includes an equal-diameter downstream tee joint 1, a horizontal water inlet end 1-1 of the equal-diameter downstream tee joint, a horizontal water outlet end 1-2 of the equal-diameter downstream tee joint, a vertical water inlet end 1-3 of the equal-diameter downstream tee joint, a connecting pipe 2, a reducer pipe 3, a soil saturated water layer forming pipe 4, porous water-permeable plates 5, sandstone inverted filters 6 and backfill soil 7.The equal-diameter downstream tee joint 1 is connected to underground capillary pipes in series.", "The horizontal water inlet end 1-1 of the equal-diameter downstream tee joint is connected with a head end direction of one capillary pipe.", "The horizontal water outlet end 1-2 of the equal-diameter downstream tee joint is connected with a rear end direction of the capillary pipe.", "Head ends of all the capillary pipes are communicated with the water supply water level control pool 201 by water supply branch pipes and water supply main pipes.", "rear ends of all the capillary pipes are connected with capillary pipe flushing valves by drainage branch pipes and drainage main pipes.", "The water supply branch pipes, the drainage branch pipes, the drainage main pipes and all the capillary pipes are located on a same horizontal plane.", "When noncapillary pipes perform flushing operation, the flushing valves are in a closed state.", "The vertical water inlet end 1-3 of the equal-diameter downstream tee joint is connected with a small head of the reducer pipe 3 by the connecting pipe 2.A lower end of the soil saturated water layer forming pipe 4 is vertically inserted into a large head of the reducer pipe 3.The porous water-permeable plates 5 are placed at the bottom of the soil saturated water layer forming pipe 4 and on one side of the large head of a diameter reducing position of the reducer pipe 3.The sandstone inverted filters 6 are placed on the porous water-permeable plates 5.The backfill soil 7 is placed on the sandstone inverted filters 6.A distance between a top end of the soil saturated water layer forming pipe 4 and a soil surface of a irrigated farmland is 40-45 cm.", "A height adjustment range of a soil saturated water layer is from the bottom of the backfill soil 7 in the soil saturated water layer forming pipe 4 to the top of the soil saturated water layer forming pipe 4.The height of the soil saturated water layer is adjusted by adjusting a water level of a corresponding water supply water level control pool 201.If the water level control device adopted by the novel pressureless irrigation device disclosed in the patent literature with a publication number of CN102160518A is adopted, only the height of a pipe port of an intake pipe of a water supply tank corresponding to the height of the soil saturated water layer needs to be adjusted.", "In embodiments of the novel irrigator for the novel pressureless irrigation device, the equal-diameter downstream tee joint 1 is a commercially available equal-diameter downstream tee joint with Φ50 made of a hard PVC material for drainage; the reducer pipe 3 is a commercially available reducer pipe with Φ50/Φ110 made of the hard PVC material for drainage; and the connecting pipe 2 is a commercially available pipe with Φ50 made of the hard PVC material for drainage.", "As shown in FIG.", "2, the novel pressureless irrigation device further includes a floating ball water level control device having a control water level adjustment mechanism and a gauge, wherein water inlet pipes 202 of the water supply water level control pool 201 horizontally penetrate through side walls of the water supply water level control pool 201 from right to left and enter the water supply water level control pool 201.Ports connected to an equal-diameter tee 203 face the right.", "A lower end of an upper connecting pipe 204 is connected with the upper port of the equal-diameter tee 203 above ports perpendicular to an upper port and a lower port of the equal-diameter tee 203.An upper end of the upper connecting pipe 204 is connected with the lower end of a female adapter 205.A square plug 206 is mounted at the upper end of the female adapter 205.The upper end of a lower connecting pipe 207 is connected with the lower port of the equal-diameter tee 203.The lower end of the lower connecting pipe 207 is connected with the upper port of a ball valve 208.The lower port of the ball valve 208 is connected with the upper end of a water distribution pipe 209.The water distribution pipe 209 has a suspended lower end and a downward pipe port.", "A horizontal head-on surface of a valve rod 210 of the ball valve 208 is inward, and is perpendicular to a plane on which the upper connecting pipe 204, the lower connecting pipe 207 and the water inlet pipes 202 in the water supply water level control pool 201 are located, and is perpendicular to the plane.", "A right upper shaft 211 is fixed inwards on the horizontal head-on surface at an upper portion of the upper connecting pipe 204.A right end of the upper connecting rod 212 is sleeved on a right upper shaft 211 after being drilled, and then is equipped with a circular gasket and a gasket fixing plug pin The upper connecting rod 212 can rotate about the shaft in the plane perpendicular to the shaft The right end of the lower connecting rod 213 is fixed to the valve rod 210.When a left end and a right end of the lower connecting rod 213 are located on the same horizontal plane, the ball valve 208 is in a closed state; when the left end of the lower connecting rod 213 is separated from the horizontal plane and moves downwards, the valve rod 210 can be driven to rotate to open the closed ball valve 208.A left lower shaft 215 is fixed inwards to the head-on surface parallel to the valve rod 210 at the lower end of a sleeve 214.The left end of the lower connecting rod 213 is sleeved on the left lower shaft 215 after being drilled and then is equipped with the circular gasket and the gasket fixing plug pin.", "A left upper shaft 216 is fixed inwards and horizontal to the head-on surface and parallel to the right upper shaft 211 on the sleeve 214 at a position with a distance equal to a distance between the valve rod 210 and the right upper shaft 211 above the left lower shaft 215 The left end of the upper connecting rod 212 is sleeved on the left upper shaft 216 after being drilled and then is equipped with the circular gasket and the gasket fixing plug pin; the distance between the right upper shaft 211 and the left upper shaft 216 is equal to the distance between the valve rod 210 and the left lower shaft 215.A pull ring 218 is fixed at the upper end of a floating box connecting rod 217.Control level gauges 219 are arranged on the upper portion of the floating box connecting rod 217 and the floating box connecting rod 217 below the pull ring 218; the lower end of the floating box connecting rod 217 penetrating through the sleeve 214 is fixed to a floating box 221 by a fixing nut 220 on the floating box 221.Control water level positioning pins 222 are mounted on an upward extended section of the sleeve 214 and on the sleeve 214 at a height higher than an upper cover plate of the water supply water level control pool 201 and convenient to operate above the left upper shaft 216.The upper connecting rod 212 and the lower connecting rod 213 move in the same plane perpendicular to the valve rod 210, the right upper shaft 211, the left lower shaft 215 and the left upper shaft 216.The pipe port of the water outlet pipe 223 of each water supply water level control pool 201 penetrates through the side wall of the water supply water level control pool 201, and is located at the bottom in the water supply water level control pool 201, and is 20-25 cm higher than a bottom surface of the water supply water level control pool 201.The other ends of the water outlet pipes 223 of the water supply water level control pool 201 are connected with the water supply main pipes in the novel irrigator for the novel pressureless irrigation device.", "As shown in FIG.", "2, the novel pressureless irrigation device further includes a photovoltaic water supply system for the novel irrigator of the novel pressureless irrigation device.", "The photovoltaic water supply system includes a photovoltaic water pumping portion, a water reservoir and the water supply water level control pool 201.The photovoltaic water pumping portion is composed of a solar battery array, a photovoltaic water pumping invertor and a water pump.", "The solar battery array is placed on the water reservoir.", "The water pump is placed at the bottom in a water source well.", "A water outlet pipe of the water pump is mounted on a water outlet of the water pump.", "The pipe port at the other end of the water outlet pipe of the water pump is located above the water reservoir and is downward.", "An overflow pipe is arranged on an upper portion of the water reservoir.", "A water inlet pipe port of the overflow pipe is formed in a side wall of the water reservoir.", "The pipe port is located in the water reservoir and is 10-15 cm lower than an upper edge of the side wall of the water reservoir.", "The other end of the overflow pipe is located outside the water reservoir and has the water outlet pipe port placed in the water source well.", "One end of the water inlet pipe 202 of each water supply water level control pool 201 is connected with the water reservoir.", "The pipe port at the end penetrates through the side wall of the water reservoir, and is located in the water reservoir and is 15-20 cm higher than the bottom surface of the water reservoir.", "The other end of the water inlet pipe 202 of each water supply water level control pool 201 horizontally penetrates through the side wall of the water supply water level control pool 201 from right to left and enters the water supply water level control pool 201.The ports connected to the equal-diameter tee 203 face the right.", "The lower end of the upper connecting pipe 204 is connected with the upper port of the equal-diameter tee 203 above the ports perpendicular to the upper port and the lower port of the equal-diameter tee 203.The upper end of the upper connecting pipe 204 is connected with the lower end of the female adapter 205.The square plug 206 is mounted at the upper end of the female adapter 205.The upper end of the lower connecting pipe 207 is connected with the lower port of the equal-diameter tee 203.The lower end of the lower connecting pipe 207 is connected with the upper port of the ball valve 208.The lower port of the ball valve 208 is connected with the upper end of the water distribution pipe 209.The water distribution pipe 209 has the suspended lower end and the downward pipe port.", "The horizontal head-on surface of the valve rod 210 of the ball valve 208 is inward, and is perpendicular to the plane on which the upper connecting pipe 204.The lower connecting pipe 207 and the water inlet pipes 202 in the water supply water level control pool 201 are located, and is perpendicular to the plane.", "The right upper shaft 211 is fixed inward on the horizontal head-on surface at the upper portion of the upper connecting pipe 204.The right end of the upper connecting rod 212 is sleeved on the right upper shaft 211 after being drilled, and then is equipped with the circular gasket and the gasket fixing plug pin; the upper connecting rod 212 can rotate about the shaft in the plane perpendicular to the shaft.", "The right end of the lower connecting rod 213 is fixed to the valve rod 210.When the left end and the right end of the lower connecting rod 213 are located on the same horizontal plane, the ball valve 208 is in the closed state.", "When the left end of the lower connecting rod 213 is separated from the horizontal plane and moves downwards, the valve rod 210 can be driven to rotate to open the closed ball valve 208.The left lower shaft 215 is fixed inwards parallel to the head-on surface of the valve rod 210 at the lower end of the sleeve 214.The left end of the lower connecting rod 213 is sleeved on the left lower shaft 215 after being drilled and then is equipped with the circular gasket and the gasket fixing plug pin.", "The left upper shaft 216 is fixed inwards and horizontal to the head-on surface and parallel to the right upper shaft 211 on the sleeve 214 at a position with a distance equal to a distance between the valve rod 210 and the right upper shaft 211 above the left lower shaft 215.The left end of the upper connecting rod 212 is sleeved on the left upper shaft 216 after being drilled and then is equipped with the circular gasket and the gasket fixing plug pin.", "The distance between the right upper shaft 211 and the left upper shaft 216 is equal to the distance between the valve rod 210 and the left lower shaft 215.The pull ring 218 is fixed at the upper end of the floating box connecting rod 217.The control level gauges 219 are arranged on the upper portion of the floating box connecting rod 217 and the floating box connecting rod 217 below the pull ring 218.The lower end of the floating box connecting rod 217 penetrating through the sleeve 214 is fixed to the floating box 221 by the fixing nut 220 on the floating box 221.The control water level positioning pins 222 are mounted on the upward extended section of the sleeve 214 and on the sleeve 214 at the height higher than an upper cover plate of the water supply water level control pool 201 and convenient to operate above the left upper shaft 216.The upper connecting rod 212 and the lower connecting rod 213 move in the same plane perpendicular to the valve rod 210, the right upper shaft 211, the left lower shaft 215 and the left upper shaft 216.The pipe port at one end of the water outlet pipe 223 of each water supply water level control pool 201 penetrates through the side wall of the water supply water level control pool 201, and is located in the water supply water level control pool 201, and is 20-25 cm higher than the bottom surface of the water supply water level control pool 201.The other ends of the water outlet pipes 223 of the water supply water level control pool 201 are connected with the water supply main pipes in the novel irrigator for the novel pressureless irrigation device.", "Preferably, the distance between the top end of the soil saturated water layer forming pipe 4 and the soil surface of the irrigated farmland is 5-10 cm greater than a maximum tractor-ploughing depth of the irrigated farmland.", "Preferably, the height adjustment range of the soil saturated water layer is from the bottom of the backfill soil 7 in the soil saturated water layer forming pipe 4 to the top of the soil saturated water layer forming pipe 4 and is 3-4 cm lower than the upper edge.", "Preferably, the height of the soil saturated water layer is controlled and adjusted by controlling and adjusting the water level of the corresponding water supply water level control pool 201 based on the “connector” principle.", "Preferably, the porous water-permeable plates 5 are sphere-shaped plates having convex surfaces placed upwards.", "In embodiments of the novel irrigator of the novel pressureless irrigation device constituted by the novel irrigator and the novel water supply system, the equal-diameter downstream tee joint 1 is the commercially available equal-diameter downstream tee joint with Φ50 made of the hard PVC material for drainage; the capillary pipe is the commercially available pipe with Φ50 made of the hard PVC material for drainage.", "The reducer pipe 3 is the commercially available reducer pipe with Φ50/Φ110 made of the hard PVC material for drainage.", "The connecting pipe 2 is a commercially available pipe with Φ50 made of the hard PVC material for drainage.", "The soil saturated water layer forming pipe 4 is a commercially available pipe with Φ110 made of the hard PVC material for drainage and has a length of 40 cm.", "The porous water-permeable plate 5 is a 15 mm thick sphere-shaped plate injection-molded by the hard PVC material, and has 6 mm-wide ribs on the plate and 8 mm-wide gaps, and has the convex surface placed upwards.", "Although the present disclosure is disclosed above by preferred embodiments, the preferred embodiments are not used to limit the present disclosure.", "Any one of those skilled in the art can make possible changes and amendments without departing from spirits and scope of the present disclosure.", "Any amendment, equivalent change and modification made to the above embodiments according to a technical essence of the present disclosure without departing from contents of technical solutions of the present disclosure fall within the protection scope defined by claims of the present disclosure." ] ]
Patent_15876108
[ [ "MEMORY DIE TEMPERATURE ADJUSTMENT BASED ON A POWER CONDITION", "A device includes a memory device and a controller.", "The controller is coupled to the memory device.", "The controller is configured to, in response to receiving a request to perform a memory access at the memory device, determine that the memory device has a characteristic indicative of a temperature crossing.", "The controller is also configured to, in response to determining that the memory device has the characteristic indicative of the temperature crossing, determine that the memory device satisfies an availability criterion.", "The controller is further configured to, in response to determining that the memory device satisfies the availability criterion, increase a temperature of the memory device by performing memory operations on the memory device until detecting a condition related to the temperature." ], [ "1.A data storage device, comprising: a memory device; and a controller coupled to the memory device, the controller including: a temperature crossing engine, wherein the temperature crossing engine is configured to reduce a bit-error rate associated with reading data; an interface; and memory.", "2.The data storage device of claim 1, wherein the temperature crossing engine is configured to perform memory operations.", "3.The data storage device of claim 2, wherein the temperature crossing engine is configured to determine whether a temperature of the memory device is less than a first temperature threshold.", "4.The data storage device of claim 3, wherein the temperature crossing engine further includes an availability detector.", "5.The data storage device of claim 4, wherein availability detector is configured to determine whether the memory device satisfies an availability condition.", "6.The data storage device of claim 5, wherein the availability detector is configured to determine an availability metric.", "7.The data storage device of claim 6, wherein the availability metric is an indication of power demand.", "8.The data storage device of claim 6, wherein the availability metric is an indication of a number of concurrent read or write operations.", "9.The data storage device of claim 6, wherein the availability metric is an indication of a number of inactive dies of the memory device.", "10.The data storage device of claim 1, wherein the temperature crossing engine is configured to heat the memory device.", "11.A method, comprising: checking a die temperature; determining that a temperature crossing condition is met; determining that an availability criteria is met; and performing a memory operation.", "12.The method of claim 11, wherein performing a memory operation includes heating a memory device.", "13.The method of claim 11, wherein determining that an availability criteria is met includes determining that a power demand is less than a power threshold.", "14.The method of claim 11, wherein determining that an availability criteria is met includes determining that a number of inactive dies is greater than an active die threshold.", "15.The method of claim 11, wherein determining that an availability criteria is met includes determining that an activity level is less than an activity threshold.", "16.A data storage device, comprises: a memory device; and a controller coupled to the memory device, the controller including: means to reduce a bit-error rate associated with reading data.", "17.The data storage device of claim 16, further comprising means to heat a memory die.", "18.The data storage device of claim 17, further comprising: means to determine that a power demand is less than a power threshold; means to determine that a number of inactive dies is greater than an active die threshold; and means to determine that an activity level is less than an activity threshold.", "19.The data storage device of claim 16, further comprising: means to determine whether a temperature of the memory device is less than a first temperature threshold.", "20.The data storage device of claim 16, further comprising means to determine whether the memory device satisfies an availability condition." ], [ "<SOH> BACKGROUND <EOH>Storage devices enable users to store and retrieve data.", "Examples of storage devices include volatile memory devices and non-volatile memory devices.", "Storage devices often include memory dies with program/erase cycles that degrade over time.", "For example, a storage device may include a memory die having a plurality of storage elements.", "A number of traps (e.g., oxide traps, interface traps, or both) may increase in the storage elements over time.", "A higher number of traps may increase a number of program pulses to program a storage element, a number of erase pulses to erase the storage element, or both.", "A memory die may be marked as erroneous and unavailable for use in response to determining that a number of program pulses to program storage elements of the memory die is greater than a program threshold, that a number of erase pulses to erase the storage elements is greater than an erase threshold, or both.", "A storage capacity of the storage device may be reduced over time as a number of memory dies marked as erroneous in the storage device increases." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>FIG.", "1 is a diagram of a particular illustrative example of a system that includes a device, such as a data storage device.", "FIG.", "2 is a diagram of a particular illustrative example of components that may be included in the device of FIG.", "1 .", "FIG.", "3 is a diagram of a particular illustrative example of a method of operation of the device of FIG.", "1 ; FIG.", "4 is a diagram of another particular illustrative example of a method of operation of the device of FIG.", "1 ; FIG.", "5 is a diagram of another illustrative example of a system that includes a device, such as a data storage device; FIG.", "6 is a diagram of a particular illustrative example of conditions detected by the device of FIG.", "5 ; FIG.", "7 is a diagram of another illustrative example of conditions detected by the device of FIG.", "5 ; FIG.", "8 is a diagram of a particular illustrative example of a method of operation of the device of FIG.", "5 ; FIG.", "9 is a diagram of another illustrative example of a method of operation of the device of FIG.", "5 ; FIG.", "10 is a diagram of another illustrative example of a system that includes a device, such as a data storage device; and FIG.", "11 is a diagram of a particular illustrative example of a method of operation of the device of FIG.", "10 .", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of and claims priority to U.S. Non-Provisional patent application Ser.", "No.", "15/225,884, filed Aug. 2, 2016, which is a continuation-in-part of and claims priority to U.S. Non-Provisional patent application Ser.", "No.", "15/061,702, filed Mar.", "4, 2016, which is a continuation-in-part of and claims priority to U.S. Non-Provisional patent application Ser No.", "14/867,999, filed Sep. 28, 2015, the contents of each of which are incorporated by reference herein in their entirety.", "FIELD OF THE DISCLOSURE The present disclosure is generally related to electronic devices and more particularly to memory die temperature adjustment based on a power condition, an aging condition, or both.", "BACKGROUND Storage devices enable users to store and retrieve data.", "Examples of storage devices include volatile memory devices and non-volatile memory devices.", "Storage devices often include memory dies with program/erase cycles that degrade over time.", "For example, a storage device may include a memory die having a plurality of storage elements.", "A number of traps (e.g., oxide traps, interface traps, or both) may increase in the storage elements over time.", "A higher number of traps may increase a number of program pulses to program a storage element, a number of erase pulses to erase the storage element, or both.", "A memory die may be marked as erroneous and unavailable for use in response to determining that a number of program pulses to program storage elements of the memory die is greater than a program threshold, that a number of erase pulses to erase the storage elements is greater than an erase threshold, or both.", "A storage capacity of the storage device may be reduced over time as a number of memory dies marked as erroneous in the storage device increases.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a diagram of a particular illustrative example of a system that includes a device, such as a data storage device.", "FIG.", "2 is a diagram of a particular illustrative example of components that may be included in the device of FIG.", "1.FIG.", "3 is a diagram of a particular illustrative example of a method of operation of the device of FIG.", "1; FIG.", "4 is a diagram of another particular illustrative example of a method of operation of the device of FIG.", "1; FIG.", "5 is a diagram of another illustrative example of a system that includes a device, such as a data storage device; FIG.", "6 is a diagram of a particular illustrative example of conditions detected by the device of FIG.", "5; FIG.", "7 is a diagram of another illustrative example of conditions detected by the device of FIG.", "5; FIG.", "8 is a diagram of a particular illustrative example of a method of operation of the device of FIG.", "5; FIG.", "9 is a diagram of another illustrative example of a method of operation of the device of FIG.", "5; FIG.", "10 is a diagram of another illustrative example of a system that includes a device, such as a data storage device; and FIG.", "11 is a diagram of a particular illustrative example of a method of operation of the device of FIG.", "10.DETAILED DESCRIPTION The present disclosure describes systems and methods of controlling memory die temperature based on detecting a characteristic indicative of an aging condition.", "For example, the aging condition may correspond to an increase in a number of traps (e.g., oxide traps, interface traps, or both) in storage elements of a memory die over time.", "A high number of traps may increase a number of program pulses to program the storage elements, a number of erase pulses to erase the storage elements, or both.", "A controller may perform a memory die healing process that includes a temperature adjustment.", "The temperature adjustment may decrease the number of traps in the storage elements of the memory die.", "Performing the memory die healing process may limit a loss of storage capacity of the memory die due to a high number of traps in the storage elements.", "In a particular aspect, a controller may determine that at least one storage element of a first die of a plurality of memory dies of a memory device has a characteristic indicative of an aging condition.", "For example, the controller may determine that a storage element of the first die has the characteristic in response to determining that a number of program pulses to change a state of the storage element fails to satisfy (e.g., is greater than) a program threshold, that a number of erase pulses to erase the storage element fails to satisfy (e.g., is greater than) an erase threshold, or both.", "The controller may, in response to determining that the at least one storage element of the first die has the characteristic indicative of the aging condition, perform a healing process by performing memory operations on the first die.", "For example, the controller may increase the temperature of the first die by performing the memory operations until detecting a temperature condition related to the temperature of the first die.", "As an example, detecting the temperature condition may include detecting that the temperature of the first die exceeds a first temperature threshold.", "As another example, detecting the temperature condition may include detecting expiration of a time period during which the temperature of the first die is maintained above a second temperature threshold.", "Performing the memory operations may include sending a request to the memory device to initiate a sequence of memory operations.", "Read/write circuitry of the memory device may be configured to perform a plurality of read operations on the first die in response to receiving the request.", "As another example, performing the memory operations may include sending a plurality of read requests to the memory device.", "The read/write circuitry may be configured to perform a read operation on the first die in response to receiving each read request of the plurality of read requests.", "Each read operation may raise a temperature of the first die.", "The controller may determine that the healing process is successful in response to determining that the at least one storage element of the first die no longer has the characteristic indicative of the aging condition.", "For example, subsequent to performance of the memory operations of the healing process, the number of program pulses to change the state of the storage element of the first die may decrease, the number of erase pulses to erase the storage element may decrease, or both.", "As a result, the storage element may no longer have the characteristic indicative of the aging condition.", "For example, the healing process may at least partially reverse the effects of aging on the first die by reducing the number of program pulses to erase the storage element, the number of erase pulses to erase the storage element, or both.", "To illustrate, the storage element may include a transistor having an insulating oxide layer between a gate and a substrate.", "During a process of writing to the storage element, electrons may be forced in one direction through the oxide layer.", "During a process of erasing the storage element, the electrons may be forced in another direction through the oxide layer.", "The oxide layer may build charge traps due to repetitive electron tunneling from writing and erasing the storage element.", "The charge traps may cause current degradation in the storage element.", "For example, the trapped charge may act as a barrier to a flow of current.", "The charge traps may increase a number of program pulses to change a state of the storage element, the number of erase pulses to erase the storage element, or both.", "The healing process may reverse the effects of aging by heating the storage element to detrap the trapped electrons from the oxide layer.", "Performing the healing process on memory dies of the storage device may limit a number of memory dies that are marked as erroneous and may maintain a storage capacity of the storage device over time.", "Particular aspects of the disclosure are described below with reference to the drawings.", "In the description, common or similar features or components may be designated by common reference numbers.", "As used herein, “exemplary” may indicate an example, an implementation, and/or an aspect, and should not be construed as indicating a preference or a preferred implementation.", "Referring to FIG.", "1, a particular illustrative example of a system is depicted and generally designated 100.The system 100 includes a device 102.In some implementations, the device 102 corresponds to a data storage device, such as a solid state drive (SSD) data storage device that is configured to be embedded within a device (e.g., a host device, a test device, or an access device) or a removable flash memory data storage device that is configured to be removed from a device (e.g., the host device, the test device, or the access device).", "In other implementations, the device 102 corresponds to another device, such as an application-specific integrated circuit (ASIC) or a system-on-chip (SoC) device, as illustrative examples.", "The device 102 includes a memory device 103.The memory device 103 includes one or more memory dies 190 (e.g., one memory die, two memory dies, sixty-four memory dies, or another number of memory dies).", "For example, the memory dies 190 may include a first memory die 104, one or more backup memory dies 106, one or more secondary memory dies 124, one or more other memory dies, or a combination thereof.", "The memory device 103 includes read/write (R/W) circuitry 116 and a temperature sensor 108.The first memory die 104 includes a memory 160, such as an array of storage elements (e.g., non-volatile storage elements).", "For example, the array of storage elements may include a first storage element 110, a second storage element 112, one or more other storage elements, or a combination thereof.", "The memory 160 may include a flash memory (e.g., a NAND flash memory) or a resistive memory, such as a resistive random access memory (ReRAM), as illustrative examples.", "The memory 160 may have a three-dimensional (3D) memory configuration.", "As used herein, a 3D memory device may include multiple physical levels of storage elements (instead of having a single physical level of storage elements, as in a planar memory device).", "As an example, the memory 160 may have a 3D vertical bit line (VBL) configuration.", "In a particular implementation, the memory 160 is a non-volatile memory having a 3D memory array configuration that is monolithically formed in one or more physical levels of arrays of memory cells having an active area disposed above a silicon substrate.", "Alternatively, the memory 160 may have another configuration, such as a two-dimensional (2D) memory configuration or a non-monolithic 3D memory configuration (e.g., a stacked die 3D memory configuration).", "The device 102 may further include a controller 120 coupled to the memory device 103.In some implementations, the controller 120 corresponds to a semiconductor die that includes components of the controller 120.The controller 120 may include an interface 118 (e.g., a memory interface) to the memory device 103.The controller 120 may include a healing engine 122, memory 140 (e.g., random access memory (RAM)), or both.", "The healing engine 122 may be implemented by software (e.g., instructions) executable by a processor to perform operations described herein.", "Alternatively, the healing engine 122 may include hardware configured to perform operations described herein.", "The healing engine 122 may be configured to heal (e.g., reduce a number of traps in) a memory die (e.g., the first memory die 104) by performing memory operations on the first memory die 104, as described herein.", "The memory 140 may be configured to store one or more instructions 162.In a particular implementation, the instructions 162, when executed by a processor, enable the processor to perform operations described herein.", "The system 100 may correspond to a solid state drive (SSD), such as found in computing devices, such as laptop computers and tablet computers.", "In some implementations, the system 100, the device 102, the memory device 103, or the memory 160 may be integrated within a network-accessible data storage system, such as an enterprise data system, a network-attached storage (NAS) system, or a cloud data storage system, as illustrative examples.", "During operation, the healing engine 122 may determine whether at least one storage element of the first memory die 104 has a characteristic indicative of an aging condition 128.For example, the healing engine 122 may determine that the first storage element 110 has a characteristic indicative of the aging condition 128 based on a number of program pulses 152 to change a state of the first storage element 110, a number of erase pulses 154 to erase the first storage element 110, or both.", "In a particular implementation, the R/W circuitry 116 may determine the number of program pulses 152 used to change a state of a particular storage element.", "For example, the R/W circuitry 116 may perform a read operation to determine that the first storage element 110 has a first state.", "To illustrate, a threshold voltage of the first storage element 110 may indicate the first state.", "The first state may indicate an n-bit value when the first storage element 110 stores n bits.", "For example, the first state may indicate a 1-bit value (e.g., “0”) when the first storage element 110 stores 1 bit.", "Alternatively, the first state may indicate a 3-bit value (e.g., “010”) when the first storage element 110 stores 3 bits.", "The R/W circuitry 116 may apply program pulses to the first storage element 110 to change the state of the first storage element 110 to a second state.", "For example, the R/W circuitry 116 may write with the program pulses and then perform a read/verify operation to detect that the first storage element 110 has the second state, where the second state indicates a second n-bit value (e.g., “1” or “001”).", "The R/W circuitry 116 may set the number of program pulses 152 to a default value (e.g., 1) prior to applying the program pulses to the first storage element 110.The R/W circuitry 116 may increment the number of program pulses 152 subsequent to (or prior to) applying each of the program pulses to the first storage element 110.Thus, the number of program pulses 152 indicates how many program pulses are used to change the state of the first storage element 110.Additionally, or in the alternative, the R/W circuitry 116 may determine the number of erase pulses 154 to erase a particular storage element.", "For example, the R/W circuitry 116 may perform a read operation to determine that the first storage element 110 has a first state.", "To illustrate, a threshold voltage of the first storage element 110 may indicate the first state.", "The R/W circuitry 116 may apply erase pulses to the first storage element 110 change the state the first storage element 110 to an erase state.", "For example, the R/W circuitry 116 may erase the first storage element 110 with the erase pulses and then perform a read/verify operation to detect that the first storage element 110 is erased.", "A particular threshold voltage of the first storage element 110 may indicate the erase state.", "The R/W circuitry 116 may set the number of erase pulses 154 to a default value (e.g., 1) prior to applying the erase pulses to the first storage element 110.The R/W circuitry 116 may increment the number of erase pulses 154 subsequent to (or prior to) applying each of the erase pulses to the first storage element 110.Thus, the number of erase pulses 154 indicates how many erase pulses are used to erase the first storage element 110.The R/W circuitry 116 may send the number of program pulses 152, the number of erase pulses 154, or both, to the controller 120.The controller 120 may receive the number of program pulses 152, the number of erase pulses 154, or both, via the interface 118.Due to repeated use, a number of traps (e.g., oxide traps, interface traps, or both) in storage elements (e.g., the first storage element 110) may increase over time.", "A higher number of traps may increase a number of program pulses to program the first storage element 110, a number of erase pulses to erase the first storage element 110, or both.", "Thus, the number of program pulses 152, the number of erase pulses 154, or both, may indicate an age (or a level of use) of the first memory die 104.The healing engine 122 may determine that the first storage element 110 has a characteristic indicative of the aging condition 128 in response to determining that the number of program pulses 152 is greater than a program threshold 142, that the number of erase pulses 154 is greater than an erase threshold 144, or both.", "For example, the healing engine 122 may determine that the first storage element 110 has the characteristic indicative of the aging condition 128 in response to determining that the number of program pulses 152 is greater than the program threshold 142, that the number of erase pulses 154 is greater than the erase threshold 144, or both.", "At least one storage element having the characteristic indicative of the aging condition 128 may indicate that the first memory die 104 has a sufficient number of traps to initiate a healing process.", "The healing engine 122 may, in response to determining that the at least one storage element (e.g., the first storage element 110) of the first memory die 104 has the characteristic indicative of the aging condition 128, perform a healing process.", "The healing process may include performing memory operations 166 (e.g., read operations, write operations, or both) on the first memory die 104 within a relatively short period of time to increase a temperature of the first memory die 104.For example, performing the memory operations 166 may include sending a sequence request 136, via the interface 118, to the memory device 103 to initiate a sequence of memory operations.", "The sequence of memory operations may include one or more read operations, one or more write operations, or a combination thereof.", "The sequence of memory operations may be performed on the first storage element 110, another storage element (e.g., the second storage element 112), or both.", "The R/W circuitry 116 may be configured to perform the sequence of memory operations on the first memory die 104 in response to receiving the sequence request 136.For example, the sequence request 136 may indicate that at least one storage element (e.g., the first storage element 110) of a memory die (e.g., the first memory die 104) has a characteristic indicative of the aging condition 128.To illustrate, the sequence request 136 may identify the first memory die 104, the first storage element 110, or both.", "The R/W circuitry 116 may perform the sequence of memory operations on the first memory die 104 in response to determining that the sequence request 136 identifies the first memory die 104.In a particular implementation, the R/W circuitry 116 may perform at least a portion of the sequence of memory operations on the first storage element 110 in response to determining that the sequence request 136 identifies the first storage element 110.As another example, performing the memory operations 166 may include sending a plurality of operation requests 134, via the interface 118, to the memory device 103.The operation requests 134 may include one or more read requests, one or more write requests, or a combination thereof.", "The R/W circuitry 116 may be configured to perform a memory operation on the first memory die 104 in response to receiving each operation request of the operation requests 134.For example, the R/W circuitry 116 may be configured to perform a read operation on the first memory die 104 in response to receiving each read request of the one or more read requests.", "The read operation may be performed on the first storage element 110 or another storage element (e.g., the second storage element 112) of the first memory die 104.As another example, the R/W circuitry 116 may be configured to perform a write operation on the first memory die 104 in response to receiving each write request of the one or more write requests.", "The write operation may be performed on the first storage element 110 or another storage element (e.g., the second storage element 112) of the first memory die 104.Execution of each memory operation (e.g., read operation or write operation) raises a temperature of the first memory die 104.Thus, the first memory die 104 can be self-heating by performing multiple memory operations in a relative short period of time.", "The healing engine 122 may cause the memory operations 166 to be performed until a temperature condition 126 related to a temperature of the first memory die 104 is detected.", "The temperature sensor 108 may generate a signal or data based on a temperature of the memory device 103.An output of the temperature sensor 108 may be provided to the controller 120 as sensor input 156.The temperature sensor 108 may be included within the first memory die 104 or located proximate to the first memory die 104.The sensor input 156 indicates a temperature 158 of the memory device 103 at or proximate to the first memory die 104.The controller 120 may receive the sensor input 156 via the interface 118.The healing engine 122 may determine the temperature 158 indicated by the sensor input 156.In a particular aspect, detecting the temperature condition 126 may include detecting that the temperature 158 exceeds a first temperature threshold 146.For example, the temperature 158 may exceed the first temperature threshold 146 for a relatively short duration (e.g., five minutes).", "In an alternate aspect, detecting the temperature condition 126 may include detecting expiration of a time period 150 during which the temperature 158 of the first memory die 104 is maintained above a second temperature threshold 176.For example, the temperature 158 may exceed the second temperature threshold 176 for a relatively long duration (e.g., 19 hours-3 weeks).", "The memory 140 may include time period data 148 indicating the time period 150.The first temperature threshold 146 may be greater than or equal to the second temperature threshold 176.The healing engine 122 may perform a first subset of the memory operations 166 to increase the temperature 158 of the first memory die 104 above the first temperature threshold 146.The healing engine 122 may, subsequent to performing the first subset of the memory operations 166, receive the sensor input 156 at a first time.", "The sensor input 156 may indicate the temperature 158.The healing engine 122 may determine that the temperature 158 exceeds the first temperature threshold 146.In a particular example, the healing engine 122 may detect the temperature condition 126 in response to determining that the temperature 158 exceeds the first temperature threshold 146.The temperature of the first memory die 104 may decrease over time due to heat dissipation.", "The healing engine 122 may receive, at a second time, a second sensor input that indicates a second temperature.", "The second temperature may be less than the first temperature threshold 146.The healing engine 122 may perform a second subset of the memory operations 166 to bring the temperature of the first memory die 104 above the first temperature threshold 146.For example, the healing engine 122 may, in response to determining that the second temperature is less than the first temperature threshold 146, perform the second subset of the memory operations 166.The healing engine 122 may, subsequent to performing the second subset of the memory operations 166, receive a third sensor input.", "The third sensor input may indicate a third temperature.", "The third temperature may exceed the first temperature threshold 146.Performing a subset of the memory operations 166 may temporarily increase the temperature of the first memory die 104.The temperature of the first memory die 104 may fall subsequent to performance of the subset of the memory operations 166 due to heat dissipation.", "The temperature of the first memory die 104 may be maintained above the second temperature threshold 176 by performing a second subset of memory operations 166 in response to detecting that the temperature of the first memory die 104 has fallen to within a range (e.g., within 5 degrees) of the second temperature threshold 176.In a particular implementation, the first temperature threshold 146 (e.g., 120 degrees Celsius) may be higher than the second temperature threshold 176 (e.g., 115 degrees Celsius).", "The difference (e.g., 5 degrees Celsius) between the first temperature threshold 146 and the second temperature threshold 176 may correspond to the range of temperatures (e.g., 115 degrees Celsius-120 degrees Celsius) that trigger a subsequent subset of the memory operations 166.The temperature of the first memory die 104, as measured by the temperature sensor 108, may be approximately equal to the first temperature threshold 146 from the first time to a heating end time.", "For example, the temperature of the first memory die 104 may vary between a first temperature (e.g., 115 degrees Celsius) and a second temperature (e.g., 125 degrees Celsius) from the first time to the heating end time.", "The first temperature and the second temperature may be proximate to the first temperature threshold 146.The temperature of the first memory die 104 may exceed the second temperature threshold 176 from the first time to the heating end time.", "The healing engine 122 may detect the temperature condition 126 in response to expiration of the time period 150.For example, the healing engine 122 may detect the temperature condition 126 in response to determining, at the heating end time, that a difference between the first time and the heating end time is greater than or equal to the time period 150.Maintaining the temperature of the first memory die 104 above the second temperature threshold 176 during the time period 150 (e.g., by causing multiple memory operations to be performed) may heal the first memory die 104.For example, subsequent to the time period 150, the number of program pulses to change the state of the first storage element 110 may decrease, the number of erase pulses to erase the first storage element 110 may decrease, or both.", "To illustrate, the R/W circuitry 116 may determine a second number of program pulses to change the state of the first storage element 110, a second number of erase pulses to erase the first storage element 110, or both.", "The second number of program pulses may be less than the number of program pulses 152.The second number of erase pulses may be less than the number of erase pulses 154.The R/W circuitry 116 may provide the second number of program pulses, the second number of erase pulses, or both, to the controller 120.The healing engine 122 may determine whether the at least one storage element (e.g., the first storage element 110) of the first memory die 104 has the characteristic indicative of the aging condition 128 based on the second number of program pulses, the second number of erase pulses, or both.", "The healing engine 122 may, in response to determining that the first storage element 110 continues to have the characteristic indicative of the aging condition 128, perform a subset (e.g., a third subset) of the memory operations 166 until the temperature condition 126 is detected.", "For example, the healing engine 122 may, in response to determining that the first storage element 110 continues to have the characteristic indicative of the aging condition 128, repeat (one or more times) the process of increasing the temperature of the first memory die 104 until the temperature condition 126 is detected.", "The healing engine 122 may, alternatively, determine that the healing process is successful in response to determining that the at least one storage element (e.g., the first storage element 110) of the first memory die 104 no longer has the characteristic indicative of the aging condition 128.In a particular implementation, the healing engine 122 may determine that the healing process is complete in response to determining that the healing process is successful or in response to determining that a healing time period has expired.", "The healing time period may begin at a begin time that the healing engine 122 starts performing the memory operations 166.The healing engine 122 may determine, at an end time, that the healing time period has expired in response to determining that a difference between the begin time and the end time satisfies (e.g., is greater than or equal to) a healing time threshold.", "The healing engine 122 may designate the first memory die 104 as erroneous in response to determining that the healing process is not successful and the healing time period has expired.", "For example, the healing engine 122 may designate the first memory die 104 as erroneous in response to determining that the at least one storage element (e.g., the first storage element 110) of the first memory die 104 continues to have the characteristic indicative of the aging condition 128 after expiration of the healing time period.", "In a particular implementation, performing the memory operations 166 on the first memory die 104 may raise a temperature of the secondary memory dies 124.For example, the secondary memory dies 124 may be proximate to the first memory die 104.In this example, the healing engine 122 may identify a particular secondary memory die of the secondary memory dies 124 in response to determining that the particular secondary memory die is within a first memory die distance from the first memory die 104.In a particular aspect, the healing engine 122 may identify the particular secondary memory die in response to determining that the particular secondary memory die is adjacent to the first memory die 104 in a first direction (e.g., a horizontal direction, a vertical direction, or a diagonal direction).", "The healing engine 122 may, prior to performing the memory operations 166, copy first data from the first memory die 104, second data from the secondary memory dies 124, or a combination thereof, to the backup memory dies 106.The healing engine 122 may copy the first data from the backup memory dies 106 to the first memory die 104, may copy the second data from the backup memory dies 106 to the secondary memory dies 124, or a combination thereof, subsequent to performing the memory operations 166.The first data may be copied to a first subset of the secondary memory dies 124.The second data may be copied to a second subset of the secondary memory dies 124.The first subset may be distinct from the second subset.", "In a particular aspect, the first subset may overlap the second subset.", "The first memory die 104, the secondary memory dies 124, or a combination thereof, may lose data during the healing process.", "For example, heating storage elements of the first memory die 104, the secondary memory dies 124, or a combination thereof, may cause the storage elements to change state.", "Copies of the first data, the second data, or both, may be preserved prior to performing the healing process by copying the first data, the second data, or both, to the backup memory dies 106.Subsequent to performing the healing process, the first data, the second data, or both, may be restored from the backup memory dies 106 to the first memory die 104, the secondary memory dies 124, or a combination thereof.", "In a particular implementation, the healing process may be performed in the background.", "For example, during the healing process, the first data, the second data, or both, may be accessed from the backup memory dies 106.Updates to the first data, the second data, or both, may be written to the backup memory dies 106 during the healing process.", "Subsequent to the healing process, the first data (e.g., the updated first data), the second data (e.g., the updated second data), or both, may be copied from the backup memory dies 106 to the first memory die 104, the secondary memory dies 124, or a combination thereof.", "At least one of the program threshold 142, the erase threshold 144, the first temperature threshold 146, or the time period data 148 may include a default value.", "In a particular implementation, the controller 120 may receive the program threshold 142, the erase threshold 144, the first temperature threshold 146, the time period data 148, or a combination thereof, from another device (e.g., a host device, a test device, or an access device).", "The program threshold 142, the erase threshold 144, first temperature threshold 146, the time period data 148, or a combination thereof, may be stored in the memory 140.Advantageously, a number of program pulses to change a state of a storage element of the first memory die 104, a number of erase pulses to erase the storage element of the first memory die 104, or both, may decrease due to the healing process.", "Thus, the first storage element 110 may not have the characteristic indicative of the aging condition 128 subsequent to performance of the healing process.", "Performing the healing process on the memory dies 190 of the device 102 may limit a number of memory dies that are marked as erroneous and may maintain a storage capacity of the device 102 over time.", "Referring to FIG.", "2, illustrative aspects of the memory dies 190 are shown.", "The memory dies 190 may include the first memory die 104, a secondary memory die 220, a memory die 222, a secondary memory die 224, a secondary memory die 226, a memory die 228, a memory die 230, a secondary memory die 232, or a combination thereof.", "In a particular aspect, the secondary memory dies 124 may include the secondary memory die 220, the secondary memory die 224, the secondary memory die 226, the secondary memory die 232, or a combination thereof.", "The healing engine 122 of FIG.", "1 may perform healing processes on the memory dies 190 by performing memory operations on a first subset of dies of the memory dies 190 based on a pattern (e.g., a checkerboard pattern).", "For example, the memory dies 190 may include the first subset of dies and a second subset of dies.", "The first subset of dies may include the first memory die 104, the memory die 222, the memory die 228, the memory die 230, or a combination thereof.", "The second subset of dies may include the secondary memory die 220, the secondary memory die 224, the secondary memory die 226, the secondary memory die 232, or a combination thereof.", "The first subset of dies and the second subset of dies may be interleaved.", "For example, the first subset of dies and the second subset of dies may include alternating dies.", "To illustrate, the first memory die 104 may be positioned between the secondary memory die 220 and the secondary memory die 226.The healing engine 122 may select the first subset of dies of the memory dies 190 for performing the memory operations 166 of FIG.", "1.The healing engine 122 may select the first subset of dies based on the pattern.", "For example, the healing engine 122 may select alternating dies of the memory dies 190.The healing engine 122 may generate a list indicating the selected dies.", "The first subset of dies may include the first memory die 104.The healing engine 122 may perform memory operations on the selected dies (e.g., the first subset of dies).", "For example, the healing engine 122 may maintain a counter indicating a next entry of the list.", "The healing engine 122 may perform memory operations on a next die corresponding to the next entry and update (e.g., increment by 1) the counter.", "Performing memory operations on the first memory die 104 may raise a temperature of one or more secondary dies (e.g., the secondary memory die 220 and the secondary memory die 226) of the second subset of dies that are proximate to the first memory die 104.Raising the temperature of the secondary dies (e.g., the secondary memory die 220 and the secondary memory die 226) may heal the secondary dies.", "For example, subsequent to performance of the memory operations 166 of FIG.", "1 on the first memory die 104, a number of program pulses to change a state of a storage element of the secondary dies (e.g., the secondary memory die 220 and the secondary memory die 226) may decrease, a number of erase pulses to erase the storage element of the secondary dies may decrease, or both.", "Similarly, subsequent to performance of memory operations 166 on the memory die 228, a number of program pulses to change a state of a storage element of secondary dies (e.g., the secondary memory die 224, the secondary memory die 226, and the secondary memory die 232) may decrease, a number of erase pulses to erase the storage element of the secondary dies may decrease, or both.", "The healing engine 122 may thus heal each of the memory dies 190 by performing memory operations on fewer than all of the memory dies 190, thereby conserving power.", "Referring to FIG.", "3, an illustrative example of a method is depicted and generally designated 300.The method 300 may be performed by the device 102, the controller 120, R/W circuitry 116, the healing engine 122 of FIG.", "1, or a combination thereof.", "The method 300 includes die age determination, at 302.For example, the healing engine 122 of FIG.", "1 may perform a die age determination of the first memory die 104 by determining the number of erase pulses 154, the number of program pulses 152, or both.", "For example, the healing engine 122 may receive the number of erase pulses 154, the number of program pulses 152, or both, from the R/W circuitry 116, as described with reference to FIG.", "1.The method 300 also includes determining whether an age threshold is crossed, at 304.For example, the healing engine 122 of FIG.", "1 may determine whether the age threshold is crossed by determining whether at least one storage element (e.g., the first storage element 110) of the first memory die 104 has a characteristic indicative of the aging condition 128.To illustrate, the healing engine 122 may determine that the age threshold is crossed in response to determining that the number of erase pulses 154 is greater than the erase threshold 144, that the number of program pulses 152 is greater than the program threshold 142, or both, as described with reference to FIG.", "1.The method 300 further includes initiating a self-healing mechanism, at 306.For example, the healing engine 122 of FIG.", "1 may cause a self-healing mechanism (e.g., a healing process) to be performed.", "The self-healing mechanism may perform the memory operations 166, as described with reference to FIG.", "1.The method 300 also includes continuing to be available for allocation, at 308.For example, the healing engine 122 of FIG.", "1 may, subsequent to performing the memory operations 166, determine that the first memory die 104 continues to be available for allocation in response to determining that the healing process is successful, as described with reference to FIG.", "1.To illustrate, the healing engine 122 may not mark the first memory die 104 as erroneous in response to determining that, subsequent to performing the healing process, a number of program pulses to change a state of the first storage element 110 is less than or equal to the program threshold 142, a number of erase pulses to erase the first storage element 110 is less than or equal to the erase threshold 144, or both.", "The method 300 may limit a number of memory dies of a storage device that are marked as erroneous and may enable a storage capacity of the storage device to be maintained over time.", "Referring to FIG.", "4, an illustrative example of a method is depicted and generally designated 400.The method 400 may be performed by the device 102, the controller 120, the healing engine 122 of FIG.", "1, or a combination thereof.", "The method 400 includes determining that at least one storage element of a first die of the plurality of memory dies has a characteristic indicative of an aging condition, at 402.For example, the healing engine 122 of FIG.", "1 may determine that the first storage element 110 of the first memory die 104 has a characteristic indicative of the aging condition 128, as described with reference to FIG.", "1.The method 400 also includes increasing the temperature of the first die by performing memory operations on the first die until detecting a condition related to the temperature, at 404.For example, the healing engine 122 of FIG.", "1 may increase the temperature of the first memory die 104 by performing the memory operations 166 on the first memory die 104 until detecting the temperature condition 126, as described with reference to FIG.", "1.The temperature condition 126 is related to the temperature of the first memory die 104.The method 400 may enable healing of the first memory die 104 by raising the temperature of the first memory die 104 using multiple memory operations.", "Healing the first memory die 104 may enable the first memory die 104 to be available for allocation and may enable a storage capacity of the device 100 of FIG.", "1 to be maintained over time.", "Referring to FIG.", "5, a particular illustrative example of a system is depicted and generally designated 500.The system 500 includes an implementation of the device 102 of FIG.", "1 that includes a temperature crossing engine 522.The device 102 may be coupled to, attached to, or embedded within one or more access devices (e.g., a device 504), such as within a housing of the device 504.The device 504 may correspond to a testing device, a host device, or both.", "The temperature crossing engine 522 may be implemented by software (e.g., instructions) executable by a processor to perform operations described herein.", "Alternatively, the temperature crossing engine 522 may include hardware configured to perform operations described herein.", "The temperature crossing engine 522 may be configured to reduce a bit-error rate associated with reading data by performing memory operations on the memory device 103, as described herein.", "The memory operations may be performed, prior to a memory access (e.g., a write access or a read access) to heat up a die of the memory device 103.For example, the memory operations may be performed in response to receiving a request to perform the memory access.", "When a read temperature corresponding to data (e.g., a temperature of the memory die when the data is read from the memory die) is similar to a write temperature corresponding to the data (e.g., a temperature of the memory die when the data is written to the memory die), bit-error rates may be reduced.", "As used herein, a “temperature crossing” refers to a difference between a read temperature and a write temperature that is likely to cause bit-errors.", "For example, a temperature crossing may refer to a situation where the read temperature is less than a first threshold and the write temperature is greater than a second threshold.", "Prior to a memory access, the temperature crossing engine 522 may detect a condition indicative of a temperature crossing, as described herein.", "For example, the temperature crossing engine 522 may detect the condition in response to receiving a request to perform the memory access.", "The temperature crossing engine 522 may perform the memory operations 166 to heat up a die of the memory device 103 in response to detecting the condition.", "During operation, the temperature crossing engine 522 may determine that a memory access (e.g., a write request 534) is to be performed on the memory device 103.In a particular aspect, the device 102 may receive a write request 532 from the device 504.The temperature crossing engine 522 may determine that the write request 534 is to be performed in response to receiving the write request 532.The temperature crossing engine 522 may, prior to performing the write request 534, determine whether the memory device 103 has a characteristic indicative of a temperature crossing, as described herein.", "The write request 534 may correspond to a request to write data at one or more storage elements (e.g., the first storage element 110, the second storage element 112, or both) of the first memory die 104.An output of the temperature sensor 108 may be provided to the controller 120 as the sensor input 156.In a particular aspect, the controller 120 may be configured to detect (e.g., receive) the sensor input 156 in response to determining that the write request 534 is to be performed, in response to receiving the write request 532, or both.", "The sensor input 156 may indicate a temperature 158 of the memory device 103 at or proximate to the first memory die 104.The temperature crossing engine 522 may determine a write temperature 546 based on the temperature 158 indicated by the sensor input 156.For example, the write temperature 546 may indicate the temperature 158.The temperature crossing engine 522 may determine, based on the write temperature 546, whether the first memory die 104 has a characteristic indicative of a temperature crossing condition 528, as further described with reference to FIG.", "6.For example, the temperature crossing engine 522 may, in response to determining that the write temperature 546 satisfies (e.g., is less than) a first temperature (temp.)", "threshold 542, determine that the first memory die 104 has the characteristic indicative of the temperature crossing condition 528.As another example, the temperature crossing engine 522 may, in response to determining that the write temperature 546 fails to satisfy (e.g., is greater than or equal to) the first temperature threshold 542, determine that the first memory die 104 does not have the characteristic indicative of the temperature crossing condition 528.The temperature crossing engine 522 may, in response to determining that the first memory die 104 does not have the characteristic indicative of the temperature crossing condition 528, determine that the memory device 103 does not have the characteristic indicative of a temperature crossing.", "The temperature crossing engine 522 may perform the write request 534 in response to determining that the memory device 103 does not have the characteristic indicative of a temperature crossing.", "For example, the temperature crossing engine 522 may provide data to the R/W circuitry 116.The R/W circuitry 116 may write the data to the first storage element 110, the second storage element 112, or both, of the first memory die 104.Alternatively, the temperature crossing engine 522 may, in response to determining that the first memory die 104 has the characteristic indicative of the temperature crossing condition 528, determine that the memory device 103 has the characteristic indicative of a temperature crossing.", "The temperature crossing engine 522 may, in response to determining that the memory device 103 has the characteristic indicative of a temperature crossing, increase a temperature of the memory device 103 (e.g., the first memory die 104) by performing the memory operations 166 (e.g., read operations, write operations, or both) on the first memory die 104 within a relatively short period of time, as described with reference to FIG.", "1.Performing the memory operations 166 may include sending an instruction (e.g., the sequence request 136), via the interface 118, to the memory device 103 to initiate a sequence of memory operations, as described with reference to FIG.", "1.The sequence of memory operations may be performed on the first storage element 110, another storage element (e.g., the second storage element 112), or both.", "The R/W circuitry 116 may be configured to perform the sequence of memory operations on the first memory die 104 in response to receiving the sequence request 136, as described with reference to FIG.", "1.For example, the sequence request 136 may indicate that at least one storage element (e.g., the first storage element 110) of a memory die (e.g., the first memory die 104) has a characteristic indicative of the temperature crossing condition 528.To illustrate, the sequence request 136 may include an instruction that identifies the first memory die 104, the first storage element 110, or both.", "The R/W circuitry 116 may perform the sequence of memory operations on the first memory die 104 in response to determining that the sequence request 136 identifies the first memory die 104.In a particular implementation, the R/W circuitry 116 may perform at least a portion of the sequence of memory operations on the first storage element 110 in response to determining that the sequence request 136 identifies the first storage element 110.As another example, performing the memory operations 166 may include sending a plurality of instructions (e.g., the plurality of operation requests 134), via the interface 118, to the memory device 103, as described with reference to FIG.", "1.The R/W circuitry 116 may be configured to perform a memory operation (e.g., a read operation or a write operation) on the first memory die 104 in response to receiving each operation request (e.g., instruction) of the operation requests 134.The memory operation may be performed on the first storage element 110 or another storage element (e.g., the second storage element 112) of the first memory die 104.Execution of each memory operation (e.g., read operation or write operation) raises a temperature of the first memory die 104, as described with reference to FIG.", "1.The temperature crossing engine 522 may cause the memory operations 166 to be performed until a temperature condition 526 related to a temperature of the first memory die 104 is detected.", "The controller 120 may, subsequent to performance of at least a subset of the memory operations 166, receive the sensor input 156 indicating the temperature 158 at or proximate to the first memory die 104.In a particular aspect, detecting the temperature condition 526 may include detecting that the temperature 158 is greater than or equal to a first temperature (temp.)", "threshold 542.The temperature crossing engine 522 may, in response to determining that the temperature 158 is less than the first temperature threshold 542, perform another subset of the memory operations 166.The controller 120 may perform the write request 534 in response to detecting the temperature condition 526.For example, detecting the temperature condition 526 may include receiving the sensor input 156 indicating the temperature 158 and determining that the temperature 158 satisfies (e.g., is greater than) the first temperature threshold 542.In a particular implementation, the write temperature 546 may represent a temperature corresponding to the first memory die 104 prior to performing the write request 534.A temperature at which data is written to the first memory die 104 may be greater than the write temperature 546 when the memory operations 166 are performed subsequent to determining the write temperature 546 and prior to performing the write request 534.In an alternate implementation, the temperature crossing engine 522 may update the write temperature 546 subsequent to performing the memory operations 166.For example, the temperature crossing engine 522 may update the write temperature 546 to indicate the temperature 158 in response to determining that the temperature 158 satisfies (e.g., is greater than) the first temperature threshold 542.The temperature crossing engine 522 may store the write temperature 546 in the memory 140 of the controller 120.In a particular aspect, the temperature crossing engine 522 may store the write temperature 546 in the memory 140 in response to determining that the write temperature 546 satisfies (e.g., is greater than) a second temperature threshold 544.The temperature crossing engine 522 may refrain from storing the write temperature 546 in the memory 140 in response to determining that the write temperature 546 fails to satisfy (e.g., is less than or equal to) the second temperature threshold 544.The write temperature 546 may be associated with the data stored at the first storage element 110, the second storage element 112, or both.", "For example, the write temperature 546 may be associated with a memory address of the data.", "To illustrate, the write temperature 546 may be stored in the memory 140 with a reference (e.g., the memory address) to a memory location of the data.", "In a particular aspect, the temperature crossing engine 522 may determine that a read request 538 is to be performed on the memory device 103.For example, the device 102 may, in response to receiving a read request 536 from the device 504, determine that the read request 538 (e.g., a memory access) is to be performed.", "The temperature crossing engine 522 may, prior to performing the read request 538, determine whether the memory device 103 has a characteristic indicative of a temperature crossing, as described herein.", "For example, the temperature crossing engine 522 may, in response to receiving the read request 536, determine whether the memory device 103 has a characteristic indicative of a temperature crossing.", "The read request 538 may correspond to a request to read data stored at one or more storage elements (e.g., the first storage element 110, the second storage element 112, or both) of the first memory die 104.The controller 120 may receive the sensor input 156 indicating the temperature 158 of the memory device 103 at or proximate to the first memory die 104.For example, the controller 120 may receive the sensor input 156 subsequent to determining that the read request 538 is to be performed.", "In a particular aspect, the controller 120 may be configured to detect (e.g., receive) the sensor input 156 in response to determining that the read request 538 is to be performed, in response to receiving the read request 536, or both.", "The temperature crossing engine 522 may determine a read temperature 548 based on the temperature 158 indicated by the sensor input 156.For example, the read temperature 548 may indicate the temperature 158.The temperature crossing engine 522 may determine, based on the read temperature 548, the write temperature 546, or both, whether the first memory die 104 has a characteristic indicative of the temperature crossing condition 528, as further described with reference to FIG.", "7.The temperature crossing engine 522 may, in response to determining that the first memory die 104 does not have the characteristic indicative of the temperature crossing condition 528, determine that the memory device 103 does not have the characteristic indicative of a temperature crossing.", "The temperature crossing engine 522 may perform the read request 538 in response to determining that the memory device 103 does not have the characteristic indicative of a temperature crossing.", "For example, the controller 120 may send the read request 538 to the R/W circuitry 116.The R/W circuitry 116 may read data from the first storage element 110, the second storage element 112, or both, of the first memory die 104.The R/W circuitry 116 may provide the data to the controller 120, and the controller 120 may provide the data to the device 504.Alternatively, the temperature crossing engine 522 may, in response to determining that the first memory die 104 has the characteristic indicative of the temperature crossing condition 528, determine that the memory device 103 has the characteristic indicative of a temperature crossing.", "The temperature crossing engine 522 may, in response to determining that the memory device 103 has the characteristic indicative of a temperature crossing, increase a temperature of the memory device 103 (e.g., the first memory die 104) by performing the memory operations 166 on the first memory die 104 within a relatively short period of time, as described herein.", "The temperature crossing engine 522 may cause the memory operations 166 to be performed until a temperature condition 526 related to a temperature of the first memory die 104 is detected.", "The controller 120 may, subsequent to performance of at least a subset of the memory operations 166, receive the sensor input 156 indicating the temperature 158 at or proximate to the first memory die 104.In a particular aspect, detecting the temperature condition 526 may include detecting that the temperature 158 is greater than or equal to the first temperature threshold 542 (or the second temperature threshold 544), as further described with reference to FIG.", "7.The temperature crossing engine 522 may, in response to determining that the temperature 158 is less than the first temperature threshold 542 (or the second temperature threshold 544), perform another subset of the memory operations 166.The temperature crossing engine 522 may perform the read request 538 in response to detecting the temperature condition 526.The read temperature 548 may thus represent a temperature corresponding to the first memory die 104 prior to performing the read request 538.A temperature at which data is read from the first memory die 104 may be greater than the read temperature 548 when the memory operations 166 are performed subsequent to determining the read temperature 548 and prior to performing the read request 538.In a particular implementation, performing the memory operations 166 on the first memory die 104 may raise a temperature of the secondary memory dies 124, as described with reference to FIG.", "1.The temperature crossing engine 522 may perform subsequent writes on one or more of the secondary memory dies 124.For example, the controller 120 may receive a second request from the device 504 to perform a write access at the memory device 103.The controller 120 may, in response to receiving the second request, perform the write access at a second die of the secondary memory dies 124 subsequent to performing the memory operations 166 on the first memory die 104.In a particular aspect, the second die may be heated by the memory operations 166 performed on the first memory die 104 and the temperature crossing engine 522 may perform fewer (e.g., no) memory operations prior to performing the write access on the second die.", "For example, a write temperature of the second die may be closer to the first temperature threshold 542 subsequent to performance of the memory operations 166 on the first memory die 104 and fewer memory operations may be used to raise the temperature of the second die to at least the first temperature threshold 542.In a particular aspect, the write temperature of the second die may be greater than or equal to the first temperature threshold 542 subsequent to performance of the memory operations 166 on the first memory die 104 and the write access to the second die may be performed without prior performance of memory operations to increase the temperature of the second die.", "In a particular aspect, the temperature crossing engine 522 may perform the memory operations 166 on a second memory die of the secondary memory dies 124 to raise a temperature of the first memory die 104.For example, the temperature crossing engine 522 may, in response to determining that the request (e.g., the write request 532 or the read request 536) corresponds to the first memory die 104, identify a second memory die of the second memory dies 124.The temperature crossing engine 522 may perform the memory operations 166 on the second memory die to increase a temperature of the first memory die 104.For example, the memory operations 166 may be performed on the second memory die to raise the temperature of the first memory die 104 in response to determining that temperatures of multiple memory dies including the first memory die 104 are to be raised.", "To illustrate, the second memory die may correspond to the secondary memory die 224 of FIG.", "2 and the temperature crossing engine 522 may determine that temperatures of the first memory die 104, the memory die 222, and the memory 228 of FIG.", "2 are to be raised, as described herein.", "Performing the memory operations 166 on the secondary memory die 224 to raise the temperature of the multiple memory dies (e.g., the first memory die 104, the memory die 222, and the memory die 228) may result in fewer memory operations being performed than performing memory operations on each of the multiple memory dies (e.g., the first memory die 104, the memory die 222, and the memory die 228).", "For example, performing memory operations on the first memory die 104 may not increase a temperature of the memory die 222 or the memory die 228 as much as performing the memory operations 166 on the secondary memory die 224 because the memory die 222 and the memory die 228 are closer to the secondary memory die 224 than to the first memory die 104.Performing the memory operations on the first memory die 104 to raise a temperature of the first memory die 104 to at least the first temperature threshold 542 may result in additional memory operations being performed on the memory die 222 and on the memory die 228 to raise the temperatures of the memory die 222 and the memory die 228 to at least the first temperature threshold 542.For example, a first number of memory operations may be performed to raise a temperature of the first memory die 104 to at least the first temperature threshold 542, a second number of memory operations may be performed to raise a temperature of the memory die 222 to at least the first temperature threshold 542, and a third number of memory operations may be performed to raise a temperature of the memory die 228 to at least the first temperature threshold 542.A sum of the first number, the second number, and the third number may be greater than a count of the memory operations 166 performed on the secondary memory die 224 to raise the temperature of each of the first memory die 104, the memory die 222, and the memory die 228 to at least the first temperature threshold 542.The temperature crossing engine 522 may thus reduce a number of memory operations performed to heat multiple dies.", "As described above, in some implementations, the controller 120 delays writing data to the memory device 103 until the temperature of the first memory die 104 meets the temperature condition 526 (e.g., is greater than the first temperature threshold 542).", "In other implementations, where the first memory die 104 includes multi-level cell (MLC) and single-level cell (SLC) storage elements, the controller 120 may write the data to the SLC storage elements prior to heating up the first memory die 104.Writing the data to the SLC storage elements prior to performing the memory operations 166 may reduce a latency associated with the write request 534 because the controller 120 may signal to the device 504 that the data is stored upon writing to the SLC storage elements.", "After the temperature of the first memory die 104 satisfies (e.g., is greater than) the first temperature threshold 542, the controller 120 may copy or ‘fold’ data from the SLC storage elements to the MLC storage elements.", "For example, the first storage element 110 may, according to an MLC scheme, indicate multiple (e.g., three) values.", "In a particular implementation, the temperature crossing engine 522 may, in response to determining that the memory device 103 has the characteristic indicative of a temperature crossing, write data of the write request 534 to one or more SLC storage elements of the memory device 103.Each of the one or more SLC storage elements may, according to a SLC scheme, indicate a single value.", "A portion of the first memory die 104 may include the one or more SLC storage elements.", "The temperature crossing engine 522 may, in response to detecting the temperature condition 526, copy the data from the one or more SLC storage elements to MLC storage elements (e.g., the first storage element 110).", "At least one of the first temperature threshold 542 or the second temperature threshold 544 may include a default value.", "In a particular implementation, the controller 120 may receive the first temperature threshold 542, the second temperature threshold 544, or both, from the device 504 (e.g., a host device, a test device, or an access device).", "The first temperature threshold 542, the second temperature threshold 544, or both, may be stored in the memory 140.Advantageously, the temperature crossing engine 522 may, prior to performing a memory access, raise a temperature of the first memory die 104 to increase a likelihood that a write temperature of data that is written to the first memory die 104 is substantially similar to a temperature at which data is read from the first memory die 104, as further described with reference to FIGS.", "6-7.When the write temperature is substantially similar to the read temperature, a number of bit errors associated with data reads at the memory device 103 may be reduced.", "Referring to FIG.", "6, a diagram 600 includes a particular illustrative example of conditions that may be detected by the device 102, the controller 120 of FIG.", "1, the temperature crossing engine 522, the system 500 of FIG.", "5, or a combination thereof.", "The temperature crossing engine 522 may, in response to determining that the write request 534 is to be performed, determine whether the first memory die 104 has a characteristic indicative of the temperature crossing condition 528 based on the write temperature 546.The diagram 600 illustrates a first case 602, a second case 604, and a third case 606.It should be understood that the first case 602, the second case 604, and the third case 606 are provided as illustrative, non-limiting examples.", "In some implementations, the temperature crossing engine 522 may use other cases to determine whether the first memory die 104 has a characteristic indicative of the temperature crossing condition 528.In the first case 602, the temperature crossing engine 522 may, in response to determining that the write temperature 546 is less than the first temperature threshold 542, determine that the first memory die 104 has the characteristic indicative of the temperature crossing condition 528.The temperature crossing engine 522 may perform the memory operations 166 until detecting that the temperature 158 at or proximate to the first memory die 104 is greater than or equal to the first temperature threshold 542, as described with reference to FIG.", "5.The temperature crossing engine 522 may perform the write request 534 subsequent to detecting that the temperature 158 is greater than or equal to the first temperature threshold 542.In the second case 604, the temperature crossing engine 522 may, in response to determining that the write temperature 546 is greater than or equal to the first temperature threshold 542 and less than or equal to the second temperature threshold 544, determine that the first memory die 104 does not have the characteristic indicative of the temperature crossing condition 528.The temperature crossing engine 522 may perform the write request 534 in response to detecting that the first memory die 104 does not have the characteristic indicative of the temperature crossing condition 528.In the third case 606, the temperature crossing engine 522 may, in response to determining that the write temperature 546 is greater than the second temperature threshold 544, determine that the first memory die 104 does not have the characteristic indicative of the temperature crossing condition 528.The temperature crossing engine 522 may perform the write request 534 and, in response to determining that the write temperature 546 is greater than the second temperature threshold 544, store the write temperature 546 in the memory 140.Referring to FIG.", "7, a diagram 700 includes a particular illustrative example of conditions that may be detected by the device 102, the controller 120 of FIG.", "1, the temperature crossing engine 522, the system 500 of FIG.", "5, or a combination thereof.", "The temperature crossing engine 522 may, in response to determining that the read request 538 is to be performed, determine whether the first memory die 104 has a characteristic indicative of the temperature crossing condition 528 based on the write temperature 546, the read temperature 548, or both.", "The diagram 700 includes a first case 702, a second case 704, a third case 706, and a fourth case 708.The temperature crossing engine 522 may perform the memory operations 166 on the memory device 103 to heat the memory device 103 to at least the first temperature threshold 542 prior to performing the write request 534, as described with reference to FIG.", "6.The temperature crossing engine 522 may perform the memory operations 166 on the memory device 103 to heat the memory device 103 to a second temperature (e.g., greater than or equal to the first temperature threshold 542 or greater than the second temperature threshold 544) prior to performing the read request 538, as described herein.", "The second temperature may be based on the write temperature 546.The temperature crossing engine 522 may, in response to determining that the read temperature 548 fails to satisfy (e.g., is less than) the first temperature threshold 542, perform the memory operations 166 to heat the memory device 103 to a temperature that satisfies (e.g., is greater than) the first temperature threshold 542.In a particular aspect, the temperature crossing engine 522 may, in response to determining that the read temperature 548 fails to satisfy (e.g., is less than or equal to) the second temperature threshold 544 and that the write temperature 546 satisfies (e.g., is greater than) the second temperature threshold 544, perform the memory operations 166 to heat the memory device 103 to a temperature that satisfies (e.g., is greater than) the second temperature threshold 544.In the first case 702, the temperature crossing engine 522 may, in response to determining that the read temperature 548 is less than the first temperature threshold 542 and that the write temperature 546 is either not stored in the memory 140 or is less than or equal to the second temperature threshold 544, determine that the first memory die 104 has the characteristic indicative of the temperature crossing condition 528.The temperature crossing engine 522 may perform the memory operations 166 until detecting that the temperature 158 at or proximate to the first memory die 104 is greater than or equal to the first temperature threshold 542, as described with reference to FIG.", "5.The temperature crossing engine 522 may perform the read request 538 subsequent to detecting that the temperature 158 is greater than or equal to the first temperature threshold 542.In the second case 704, the temperature crossing engine 522 may, in response to determining that the write temperature 546 is not stored in the memory 140 or that the write temperature 546 is less than or equal to the second temperature threshold 544, and that the read temperature 548 is greater than or equal to the first temperature threshold 542, determine that the first memory die 104 does not have the characteristic indicative of the temperature crossing condition 528.The temperature crossing condition 528 may correspond to a condition where performing the memory operations 166 may reduce bit-errors caused by a temperature crossing.", "In a particular aspect, a temperature (e.g., warm) of the first memory die 104 when the write request 534 is performed may be substantially the same as the read temperature 548 (e.g., warm) and the temperature crossing engine 522 may determine that the first memory die 104 does not indicate a characteristic indicative of a temperature crossing and thus does not have the characteristic indicative of the temperature crossing condition 528.In another aspect, the read temperature 548 (e.g., hot) may be greater than the temperature (e.g., warm) of the first memory die 104 when the write request 534 was performed.", "Performing the memory operations 166 prior to performing the read request 538 may raise the temperature of the first memory die 104 thereby causing more bit-errors by increasing a difference between the temperature (e.g., warm) of the first memory die 104 when the write request 534 was performed and a temperature (e.g., hotter) of the first memory die 104 when the read request 538 is performed.", "The temperature crossing engine 522 may determine that the first memory die 104 indicates a characteristic indicative of a temperature crossing.", "The temperature crossing engine 522 may, in response to determining that performing the memory operations 166 will not reduce bit-errors, determine that the first memory die 104 does not have the characteristic indicative of the temperature crossing condition 528.The temperature crossing engine 522 may perform the read request 538 without using the memory operations 166 to heat the first memory die 104.In the third case 706, the temperature crossing engine 522 may, in response to determining that the write temperature 546 is stored in the memory 140, that the write temperature 546 is greater than the second temperature threshold 544, or both, and that the read temperature 548 is less than or equal to the second temperature threshold 544, determine that the first memory die 104 has the characteristic indicative of the temperature crossing condition 528.The temperature crossing engine 522 may perform the memory operations 166 until detecting that the temperature 158 at or proximate to the first memory die 104 is greater than the second temperature threshold 544, as described with reference to FIG.", "5.The temperature crossing engine 522 may perform the read request 538 subsequent to detecting that the temperature 158 is greater than the second temperature threshold 544.In the fourth case 708, the temperature crossing engine 522 may, in response to determining that the write temperature 546 is stored in the memory 140, that the write temperature 546 is greater than the second temperature threshold 544, or both, and that the read temperature 548 is greater than the second temperature threshold 544, determine that the first memory die 104 does not have the characteristic indicative of the temperature crossing condition 528.The temperature crossing engine 522 may perform the read request 538 in response to detecting that the first memory die 104 does not have the characteristic indicative of the temperature crossing condition 528.The temperature crossing engine 522 may perform the read request 538 without using the memory operations 166 to heat the first memory die 104.In the first case 702, the temperature crossing engine 522 may reduce a bit-error rate associated with data reads at the memory device 103 by performing the memory operations 166 prior to performing the read request 538.In the first case 702, the write temperature 546 and the read temperature 548 may both be less than the first temperature threshold 542 (e.g., cold).", "The temperature crossing engine 522 may perform the memory operations 166 prior to performing the write request 534 and also prior to performing the read request 538 such that a temperature (e.g., warm) of the first memory die 104 when the read request 538 is performed is substantially similar to a temperature (e.g., warm) of the first memory die 104 when the write request 534 is performed.", "Alternatively, in the first case 702, the write temperature 546 (e.g., warm) may be greater than or equal to the first temperature threshold 542 and less than or equal to the second temperature threshold 544.The temperature crossing engine 522 may refrain from performing the memory operations 166 prior to performing the write request 534.The read temperature 548 (e.g., cold) may be less than the first temperature threshold 542.The temperature crossing engine 522 may perform the memory operations 166 prior to performing the read request 538 such that a temperature (e.g., warm) of the first memory die 104 when the read request 538 is performed is substantially similar to a temperature (e.g., warm) of the first memory die 104 when the write request 534 is performed.", "In the second case 704, in a particular aspect, the read temperature 548 (e.g., warm) may be substantially similar to a temperature of the first memory die 104 when the write request 534 is performed and the temperature crossing engine 522 may refrain from performing the memory operations 166 prior to performing the read request 538.For example, the write temperature 546 (e.g., warm) may be greater than or equal to the first temperature threshold 542 and less than or equal to the second temperature threshold 544.The temperature crossing engine 522 may, in response to determining that the write temperature 546 (e.g., warm) is greater than or equal to the first temperature threshold 542 and less than or equal to the second temperature threshold 544, determine that the first memory die 104 does not have a characteristic indicative of the temperature crossing condition 528.The temperature crossing engine 522 may, in response to determining that the first memory die 104 does not have a characteristic indicative of the temperature crossing condition 528, refrain from performing the memory operations 166 prior to performing the write request 534.The read temperature 548 may be unknown at the time of performing the write request 534.A first likelihood that the read temperature 548 is less than or equal to the second temperature threshold 544 may be higher than a second likelihood that the read temperature 548 is greater than the second temperature threshold 544.When the first likelihood is greater than the second likelihood, refraining from performing the memory operations 166 in response to determining that the write temperature 546 (e.g., warm) is greater than or equal to the first temperature threshold 542 and less than or equal to the second temperature threshold 544 may reduce an overall number of memory operations performed.", "For example, refraining from performing the memory operations 166 to raise a temperature of the first memory die 104 above the second temperature threshold 544 prior to performing the write request 534 may result in fewer memory operations being performed to raise a temperature of the first memory die 104 to at least the first temperature threshold 542 when the read temperature 548 is less than the first temperature threshold 542.As another example, when the read temperature 548 is greater than or equal to the first temperature threshold 542 and less than or equal to the second temperature threshold 544, refraining from performing the memory operations 166 to raise a temperature of the first memory die 104 above the second temperature threshold 544 prior to performing the write request 534 may result in no memory operations being performed prior to performing the read request 538.When the read temperature 548 has a greater likelihood of being less than or equal to the second temperature threshold 544, refraining from performing the memory operations 166 to raise a temperature of the first memory die 104 above the second temperature threshold 544 prior to performing the write request 534 may result in fewer memory operations being performed prior to performing the read request 538.As another example, the write temperature 546 (e.g., cold) may be less than the first temperature threshold 542 and the temperature crossing engine 522 may perform the memory operations 166 prior to performing the write request 534.The read temperature 548 (e.g., warm) may be greater than or equal to the first temperature threshold 542 and less than or equal to the second temperature threshold 544.Performing the memory operations 166 prior to performing the write request 534 may cause a temperature of the first memory die 104 when the write request 534 is performed to be substantially the same as the read temperature 548.A temperature (e.g., warm) of the first memory die 104 when the read request 538 is performed may be substantially similar to a temperature (e.g., warm) of the first memory die 104 when the write request 534 is performed.", "Performing the memory operations 166 prior to performing the write request 534 may result in the first memory die 104 not having a characteristic indicative of a temperature crossing prior to performing the read request 538.Bit-errors associated with a temperature crossing may thus be reduced (e.g., eliminated).", "In the second case 704, in an alternate aspect, the read temperature 548 (e.g., hot) may be higher than a temperature of the first memory die 104 when the write request 534 is performed.", "The write temperature 546 (e.g., cold) may be less than the first temperature threshold 542 and the temperature crossing engine 522 may perform the memory operations 166 prior to performing the write request 534, thereby at least reducing the difference between the temperature (e.g., warm) at which the write request 534 is performed and the temperature (e.g., hot) at which the read request 538 is performed.", "A temperature crossing corresponding to a lower difference between the temperature (e.g., warm) at which the write request 534 is performed and the temperature (e.g., hot) at which the read request 538 is performed may result in fewer bit-errors than a temperature crossing corresponding to a higher difference between the temperature (e.g., cold) at which the write request 534 is performed and the temperature (e.g., hot) at which the read request 538 is performed.", "Performing the memory operations 166 prior to performing the write request 534 may thus reduce bit-errors associated with a temperature crossing.", "Alternatively, the write temperature 546 (e.g., warm) may be greater than or equal to the first temperature threshold 542 and less than or equal to the second temperature threshold 544.The temperature crossing engine 522 may refrain from performing the memory operations 166 prior to performing the write request 534 because the read temperature 548 (e.g., hot) is unknown at the time of performing the write request 534.For example, the temperature crossing engine 522 may refrain from performing the memory operations 166 prior to performing the write request 534 to reduce a number of overall memory operations when a first likelihood that the read temperature 548 is less than or equal to the second temperature threshold 544 is greater than a second likelihood that the read temperature 548 is greater than the second temperature threshold 544.The temperature crossing engine 522 may refrain from performing the memory operations 166 prior to performing the read request 538 because raising the temperature of the first memory die 104 would further increase a difference between a temperature (e.g., warm) at which the write request 534 was performed and a temperature (e.g., hot) at which the read request 538 is performed.", "In the third case 706, the temperature crossing engine 522 may reduce a bit-error rate associated with data reads at the memory device 103 by performing the memory operations 166 prior to performing the read request 538.In the third case 706, the write temperature 546 (e.g., hot) may be greater than the second temperature threshold 544 and the read temperature 548 (e.g., cold or warm) may be less than the second temperature threshold 544.The temperature crossing engine 522 may perform the memory operations 166 prior to performing the read request 538 such that a temperature (e.g., hot) of the first memory die 104 when the read request 538 is performed is substantially similar to a temperature (e.g., hot) of the first memory die 104 when the write request 534 is performed.", "As a result of performing the memory operations 166 prior to performing the read request 538, the first memory die 104 may not have a characteristic indicative of a temperature crossing.", "Bit-errors associated with a temperature crossing may thus be reduced (e.g., eliminated).", "In the fourth case 708, the read temperature 548 may be substantially similar to a temperature of the first memory die 104 when the write request 534 is performed and the temperature crossing engine 522 may refrain from performing the memory operations 166 prior to performing the read request 538.In the fourth case 708, the write temperature 546 (e.g., hot) and the read temperature 548 (e.g., hot) may both be greater than the second temperature threshold 544.The temperature crossing engine 522 may refrain from performing the memory operations 166 prior to performing the write request 534 and may also refrain from performing the memory operations 166 prior to performing the read request 538.A temperature (e.g., hot) of the first memory die 104 when the read request 538 is performed may be substantially similar to a temperature (e.g., hot) of the first memory die 104 when the write request 534 is performed without performing the memory operations 166.The temperature crossing engine 522 may reduce a bit-error rate in at least one of the first case 702, the second case 704, or the third case 706 by performing the memory operations 166 prior to the write request 534, performing the memory operations 166 prior to the read request 538, or both.", "It should be understood that the first case 702, the second case 704, the third case 706, and the fourth case 708 are provided as illustrative, non-limiting examples.", "In some implementations, the temperature crossing engine 522 may use other cases to determine whether the first memory die 104 has a characteristic indicative of the temperature crossing condition 528.For example, the temperature crossing engine 522 may, prior to performing the write request 534, determine that the first memory die 104 has a characteristic indicative of the temperature crossing condition 528 in response to determining that the write temperature 546 is less than or equal to the second temperature threshold 544.In this example, the temperature crossing engine 522 may, prior to performing the read request 538, determine that the first memory die 104 has a characteristic indicative of the temperature crossing condition 528 in response to determining that the read temperature 548 is less than or equal to the second temperature threshold 544.In this example, a temperature (e.g., hot) of the first memory die 104 when the write request 534 is performed may be substantially similar to a temperature (e.g., hot) of the first memory die 104 when the read request 538 is performed.", "The temperature crossing engine 522 may reduce a bit-error rate by performing the memory operations 166 prior to the write request 534, performing the memory operations 166 prior to the read request 538, or both.", "Referring to FIG.", "8, an illustrative example of a method is depicted and generally designated 800.The method 800 may be performed by the device 102, the controller 120 of FIG.", "1, the temperature crossing engine 522, the system 500 of FIG.", "5, or a combination thereof.", "The method 800 includes checking die temperature, at 802.For example, the temperature crossing engine 522 of FIG.", "5 may determine the write temperature 546 based on the sensor input 156, as described with reference to FIG.", "5.The sensor input 156 may indicate the temperature 158 at or proximate to the first memory die 104.The method 800 also includes determining whether a temperature crossing condition is met, at 804.For example, the temperature crossing engine 522 of FIG.", "5 may determine whether the temperature crossing condition 528 is detected, as described with reference to FIGS.", "5-7.The method 800 includes, in response to determining that the temperature crossing condition is met, at 804, applying a temperature crossing mitigation operation, at 806.For example, the temperature crossing engine 522 of FIG.", "5 may, in response to detecting the temperature crossing condition 528, perform the memory operations 166 until the temperature condition 526 is detected, as further described with reference to FIGS.", "5-6.The method 800 includes, in response to determining that the temperature crossing condition is not met, at 804, proceeding to 808.The method 800 also includes performing one or more memory access operations while the temperature crossing condition is not met (e.g., after performing the 806).", "For example, the method 800 may include writing to a die, at 808.For example, the controller 120 may perform the write request 534 at the first memory die 104, as described with reference to FIG.", "5.As another example, the method 800 may include reading from the die, at 810.For example, the controller 120 may perform the read request 538 at the first memory die 104, as described with reference to FIG.", "5.The method 800 may, by heating the first memory die 104 prior to writing the data, prior to reading the data, or both, reduce a difference between a first temperature at which data is read from the first memory die 104 and a second temperature at which data is written to the first memory die 104.For example, the first temperature may be substantially similar (e.g., warm) to the second temperature.", "The reduction in (e.g., elimination of) the temperature difference may reduce a bit-error rate associated with performing data reads at the memory device 103.Referring to FIG.", "9, an illustrative example of a method is depicted and generally designated 900.The method 900 may be performed by the device 102, the controller 120 of FIG.", "1, the temperature crossing engine 522, the system 500 of FIG.", "5, or a combination thereof.", "The method 900 includes, in response to receiving a request to perform a memory access at a memory device, determining that the memory device has a characteristic indicative of a temperature crossing, at 902.For example, the temperature crossing engine 522 of FIG.", "5 may, in response to receiving a request (e.g., the read request 536 or the write request 532) to perform a memory access (e.g., the write request 534 or the read request 538), determine that the memory device 103 has a characteristic indicative of a temperature crossing, as described with reference to FIGS.", "5-7.The method 900 also includes, in response to the determination, increasing a temperature of the memory device by performing memory operations on the memory device until detecting a condition related to the temperature, at 904.For example, the temperature crossing engine 522 of FIG.", "5 may, in response to determining that the memory device 103 has a characteristic indicative of a temperature crossing, perform the memory operations 166 until detecting the temperature condition 526, as further described with reference to FIGS.", "5-7.The method 900 may correspond to one or more of the cases of FIGS.", "6-7.The method 900 may, by heating the first memory die 104 prior to a data write, prior to a data read, or both, reduce a difference between a first temperature at which data is read from the first memory die 104 and a second temperature at which data is written to the first memory die 104.For example, the first temperature may be substantially similar to the second temperature.", "The reduction in (e.g., elimination of) the temperature difference may reduce a bit-error rate associated with performing data reads at the memory device 103.Referring to FIG.", "10, a particular illustrative example of a system is depicted and generally designated 1000.The system 1000 includes an implementation of the device 102 of FIG.", "1 that includes a temperature crossing engine 1022.The device 102 may be coupled to, attached to, or embedded within one or more access devices (e.g., a device 1004), such as within a housing of the device 1004.The device 1004 may correspond to a testing device, a host device, or both.", "The temperature crossing engine 1022 may be implemented by software (e.g., instructions) executable by a processor to perform operations described herein.", "Alternatively, the temperature crossing engine 1022 may include hardware configured to perform operations described herein.", "In a particular implementation, the temperature crossing engine 1022 may include or correspond to the temperature crossing engine 522 of FIG.", "5.In this implementation, the temperature crossing engine 1022 includes the features and functions described with reference to FIG.", "5 and includes an availability detector 1050, as described further below.", "In other implementations, the temperature crossing engine 1022 includes the availability detector 1050 and omits one or more of the features or functions of the temperature crossing engine 522 of FIG.", "5.The temperature crossing engine 1022 may be configured to reduce a bit-error rate associated with reading data by heating the memory device 103, as described herein.", "When a read temperature corresponding to data (e.g., a temperature of the memory die when the data is read from the memory die) is similar to a write temperature corresponding to the data (e.g., a temperature of the memory die when the data is written to the memory die), bit-error rates may be reduced.", "As used herein, a “temperature crossing” refers to a difference between a read temperature and a write temperature that is likely to cause bit-errors.", "To mitigate the risk of errors due to temperature crossing, the temperature crossing engine 1022 may perform memory operations to heat the memory device 103 when a temperature of the memory device 103 is below a threshold and when the memory operations are unlikely to interfere with performing operations requested by the device 1004.For example, the temperature crossing engine 1022 may detect a condition indicating that a temperature of the memory device 103 is less than a first threshold (e.g., a first temperature threshold 1042) and that an availability metric 1052 satisfies an availability criterion 1054.The temperature crossing engine 1022 may perform the memory operations 166 to heat up a die of the memory device 103 in response to detecting the condition.", "During operation, the temperature crossing engine 1022 may determine whether a temperature of the memory device is less than the first temperature threshold 1042.For example, an output of the temperature sensor 108 may be provided to the controller 120 as the sensor input 156.The sensor input 156 may indicate a temperature 158 of the memory device 103 or a temperature of a portion of the memory device 103, such as a temperature of the first memory die 104.The temperature crossing engine 1022 may compare the temperature 158 to the first temperature threshold 1042.If the temperature 158 fails to satisfy (e.g., is less than) the first temperature threshold 1042, the temperature crossing engine 1022 may determine whether the memory device 103 satisfies an availability criterion 1054.For example, the temperature crossing engine 1022 may include an availability detector 1050 configured to determine or monitor an availability metric 1052.The availability metric 1052 may be indicative of demand, usage, or activity at the memory device 103.To illustrate, the availability metric 1052 may include or correspond to a measure or indication of power demand at the memory device 103 (or at the device 102), may include or correspond to a measure or indication of number of inactive dies at the memory device 103, may include or correspond to a measure or indication of an activity level (e.g., a number of concurrent read or write operations) at the memory device 103, another indication of demand, usage, or activity at the memory device 103, or a combination thereof.", "As a specific example, power available to the device 102 may be limited by a power supply (not shown) of the device 102 or external to the device 102.In this example, the availability metric 1052 may include a power metric indicating power demand at the device 102 or a portion (e.g., a percentage) of available power being used by the device 102.The temperature crossing engine 1022 may compare the availability metric 1052 to the availability criterion 1054 to determine whether the memory device 103 satisfies the availability criterion 1054.For example, when the availability metric 1052 indicates an activity level at the memory device 103 (e.g., a number of concurrent memory operations), the availability criterion 1054 may be satisfied if the activity level is less than an activity threshold.", "To illustrate, the memory device 103 may include multiple memory dies 190, and the number of concurrent memory operations that can be performed at the multiple memory dies 190 may be limited due to power constraints, bus constraints, or other constraints.", "In this example, the availability criterion 1054 may limit the activity level sufficiently that if the device 1004 issues an access request, such as the write request 532 or the read request 536, the memory device 103 has sufficient capacity to perform operations associated with the access request.", "As another example, when the availability metric 1052 indicates power demand at the memory device 103, the availability criterion 1054 may be satisfied if the power demand is less than a power threshold.", "To illustrate, performing multiple concurrent read or write operations at the memory device 103 may use a first portion of power available to the memory device 103.In this example, the availability criterion 1054 may limit the power demand sufficiently that if the device 1004 issues an access request, such as the write request 532 or the read request 536, the memory device 103 has sufficient additional power capacity to perform operations associated with the access request.", "As another example, the availability metric 1052 may indicate a number of inactive dies of the memory device 103 or a number of active dies of the memory device 103.In this example, the availability criterion 1054 may be satisfied if the number of inactive dies is greater than an active die threshold, or if the number of active dies is less than or equal to the active die threshold.", "In this context, an active die refers to a memory die that is performing memory access operations at a particular time, and an inactive die refers to memory die that is not performing memory access operations at the particular time.", "Alternatively, in some implementations, an active die refers to a memory die that is marked (e.g., in a table or other data structure in the memory 140) as available for use at a particular time, and an inactive die refers to a memory die that is marked (e.g., in the table or other data structure in the memory 140) as not available for use at the particular time.", "In this example, the availability criterion 1054 may limit the number of active dies sufficiently that if the device 1004 issues an access request, such as the write request 532 or the read request 536, the memory device 103 has at least one memory die available to perform operations associated with the access request.", "If the memory device 103 satisfies the availability criterion 1054, the temperature crossing engine 1022 may increase the temperature of the memory device 103.For example, the temperature crossing engine 1022 may perform a set of memory operations at the memory device 103 until detecting a condition related to the temperature of the memory device 103.The condition related to the temperature of the memory device 103 may include or correspond to the temperature 158 indicated by the sensor input 156 satisfying (e.g., being greater than or equal to) a second temperature threshold 1044.The set of memory operations may include read operations, write operations, or both, that are performed within a relatively short period of time, as described with reference to FIG.", "1.Performing the set of memory operations may include sending an instruction (e.g., the sequence request 136), via the interface 118, to the memory device 103 to initiate the set (e.g., a sequence) of memory operations, as described with reference to FIG.", "1.The set of memory operations may be performed on the first storage element 110, another storage element (e.g., the second storage element 112), or both.", "The R/W circuitry 116 may be configured to perform the set of memory operations in response to receiving the sequence request 136, as described with reference to FIG.", "1.For example, the sequence request 136 may indicate that at least one storage element (e.g., the first storage element 110) of a memory die (e.g., the first memory die 104) on which the set of memory operations are to be performed.", "In this example, the R/W circuitry 116 performs the set of memory operations on the first memory die 104 in response to determining that the sequence request 136 identifies the first memory die 104.In a particular implementation, the R/W circuitry 116 may perform at least a portion of the set of memory operations on the first storage element 110 in response to determining that the sequence request 136 identifies the first storage element 110.As another example, performing the set of memory operations may include sending a plurality of instructions (e.g., the plurality of operation requests 134), via the interface 118, to the memory device 103, as described with reference to FIG.", "1.The R/W circuitry 116 may be configured to perform a memory operation (e.g., a read operation or a write operation) on the first memory die 104 in response to receiving each operation request (e.g., instruction) of the operation requests 134.The memory operation may be performed on the first storage element 110 or another storage element (e.g., the second storage element 112) of the first memory die 104.Execution of each memory operation (e.g., read operation or write operation) raises a temperature of the first memory die 104, as described with reference to FIG.", "1.The temperature crossing engine 1022 may cause the memory operations of the set of memory operations to be performed until a temperature condition 1026 related to a temperature of the first memory die 104 is detected.", "For example, the memory operations may be performed until the temperature 158 of the memory device 103 satisfies (e.g., is greater than or equal to) the second temperature threshold 1044.In this example, when temperature crossing engine 1022 detects that the temperature 158 of the memory device 103 satisfies the second temperature threshold 1044, the controller 120 may cease sending the operations requests 134 or may instruct the memory device 103 to cease performing the memory operations associated with the sequence request 136.In some implementations, the temperature crossing engine 1022 may cause the memory operations to cease in response to detecting that the availability metric 1052 has ceased to satisfy the availability criterion 1054.To illustrate, during a period of low activity (e.g., when few requests are received from the device 1004, the temperature 158 of the memory device 103 may drop below the first temperature threshold 1042.The temperature crossing engine 1022 may cause the memory operations to be performed at the memory device 103 to increase the temperature toward the second temperature threshold 1044.While the temperature crossing engine 1022 is attempting to increase the temperature 158 of the memory device 103, the period of inactivity of the device 1004 may cease and the device 1004 may issue a number of memory access requests.", "The availability detector 1050 may detect the increase in activity associated with the device 1004, and the temperature crossing engine 1022 may cause the memory operations (that are performed to increase the temperature 158 of the memory device 103) to cease responsive to the availability metric 1052 failing to satisfy the availability criterion 1054.In a particular implementation, performing the memory operations on the first memory die 104 may raise a temperature of the secondary memory dies 124, as described with reference to FIG.", "1.Thus, a second die of the secondary memory dies 124 may be heated by the memory operations performed on the first memory die 104.Conversely, the temperature of the first memory die 104 may be increased by performing memory operations at one or more of the secondary memory dies 124.In a particular aspect, the temperature crossing engine 1022 may perform the memory operations on a second memory die of the secondary memory dies 124 to raise a temperature of the first memory die 104.For example, the temperature crossing engine 1022 may determine that the first memory die is an active die and that a temperature sensor on or near the first memory die 104 indicates a temperature that is less than the first temperature threshold 1042.In this example, the temperature crossing engine 1022 may cause memory operations to be performed at one or more inactive memory dies of the secondary memory dies 124 to heat the first memory die 104.To illustrate, the temperature crossing engine 1022 may select particular set of one or memory dies (of the secondary memory dies 124) to perform the memory operation based on proximity of the set of one or more memory dies to the first memory die 104.In an alternative implementation, the temperature crossing engine 1022 may select a set of memory dies that are distributed among the memory dies 190 to perform the memory operation.", "In this implementation, the set of memory dies may be selected (e.g., randomly or pseudo-randomly) such that the memory dies performing the memory operations are scattered (or distributed) among the memory dies 190 of the memory device 103 to facilitate relatively even heating of the memory device 103.As described above, in some implementations, the controller 120 delays writing data to the memory device 103 until the temperature of the first memory die 104 meets a temperature condition 1026 (e.g., is greater than the first temperature threshold 1042).", "In other implementations, where the first memory die 104 includes multi-level cell (MLC) and single-level cell (SLC) storage elements, the controller 120 may write the data to the SLC storage elements until the temperature of the first memory die 104 satisfies the temperature condition 1026.Writing the data to the SLC storage elements until the temperature of the first memory die 104 satisfies the temperature condition 1026 may reduce a latency associated with the write request 534 because the controller 120 may signal to the device 1004 that the data is stored upon writing to the SLC storage elements.", "After the temperature of the first memory die 104 satisfies (e.g., is greater than) the first temperature threshold 1042, the controller 120 may copy or ‘fold’ data from the SLC storage elements to the MLC storage elements.", "For example, the first storage element 110 may, according to an MLC scheme, indicate multiple (e.g., three) values.", "At least one of the first temperature threshold 1042 or the second temperature threshold 1044 may include a default value.", "In a particular implementation, the controller 120 may receive the first temperature threshold 1042, the second temperature threshold 1044, or both, from the device 1004 (e.g., a host device, a test device, or an access device).", "The first temperature threshold 1042, the second temperature threshold 1044, or both, may be stored in the memory 140.Additionally, the availability criterion 1054 may include a default value, such as a power threshold set according to a power specification.", "In some implementation, the availability criterion 1054 may include a value based on user input or based on information provided by the device 1004.To illustrate, a user or the device 1004 may provide an indication that is associated with a power limit (e.g., an indication that the device 1004 is operating on battery power) or performance limit (e.g., an indication that a particular performance requirement is to be satisfied).", "In such implementations, the availability criterion 1054 may be set or modified based on the value based on user input or based on information provided by the device 1004.To illustrate, if a power limit is specified, the controller 120 may modify the availability criterion 1054 based on a decrease in available power indicated by the power limit.", "Advantageously, the temperature crossing engine 1022 may raise a temperature of the first memory die 104 during periods of low activity (e.g., when the availability criterion 1054 is satisfied) to increase a likelihood that a write temperature of data that is written to the first memory die 104 is substantially similar to a temperature at which data is read from the first memory die 104 without decreasing performance associated with access requests received from the device 1004.When the write temperature is substantially similar to the read temperature, a number of bit errors associated with data reads at the memory device 103 may be reduced.", "Referring to FIG.", "11, an illustrative example of a method is depicted and generally designated 1100.The method 1100 may be performed by the device 102, the controller 120 of FIG.", "1, the temperature crossing engine 522 of FIG.", "5, the system 500 of FIG.", "5, the temperature crossing engine 1022 of FIG.", "10, the system 1000 of FIG.", "10, or a combination thereof.", "The method 1100 includes checking die temperature, at 1102.For example, the temperature crossing engine 1022 of FIG.", "10 may determine the temperature 158 based on the sensor input 156, as described with reference to FIG.", "10.The sensor input 156 may indicate the temperature 158 at or proximate to the first memory die 104.The method 1100 also includes determining whether a temperature condition is met, at 1104.For example, the temperature crossing engine 1022 of FIG.", "10 may determine whether the temperature condition 1026 is satisfied.", "The temperature condition 1026 may be satisfied when the temperature 158 is greater than the first temperature threshold 1042, as described with reference to FIG.", "10.The method 1100 includes, in response to determining that the temperature condition is met, at 1104, determining whether an availability criterion is met, at 1106.For example, the temperature crossing engine 1022 of FIG.", "10 may determine whether the availability criterion 1054 is satisfied based on the availability metric 1052, as described with reference to FIG.", "10.The method 1100 includes, in response to determining that availability criterion is met, performing one or more memory operations, at 1108.The memory operations may include read operations, write operations, or both.", "For example, performing the memory operations may include performing the memory operation indicated by the sequence request 136 of FIG.", "10.As another example, performing the memory operations may include performing a number of distinct memory operations responsive to the operation requests 134 of FIG.", "10.After one or more memory operation have been performed, the method 1100 may return to 1102 to check the temperature of the die.", "For example, the temperature crossing engine 1022 of FIG.", "10 may, in response to detecting that the temperature condition 1026 is met and in the availability metric 1052 satisfies the availability criterion 1054, perform the memory operations 166 until the temperature 158 satisfies the second temperature threshold 1044.The method 1100 includes, in response to determining that the temperature condition is not met, at 1104, or in response to determining that the availability condition is not met, at 1106, returning to 1102.Thus, the method 1100 may heat the memory die during periods of low activity (e.g., when the availability criterion is satisfied).", "Heating the die may reduce temperature crossing associated with read and write operations of the die.", "For example, by heating the die, a temperature difference between a first temperature at which data is written and a second temperature at which the data is read may be reduced.", "The reduction in (e.g., elimination of) the temperature difference may reduce a bit-error rate associated with performing data reads at the memory device 103.In some implementations, a computer-readable medium stores instructions executable by a processing module to perform operations.", "For example, the computer-readable medium may correspond to the memory 140, the instructions may correspond to the instructions 162, and the processing module may correspond to the healing engine 122, the temperature crossing engine 522, the temperature crossing engine 1022, or a combination thereof.", "The operations include performing memory operations (e.g., the memory operations 166) to increase a temperature of a memory die (e.g., the first memory die 104) until detecting a condition (e.g., the temperature condition 126) related to the temperature of the memory die (e.g., the first memory die 104).", "The memory operations may be performed responsive to determining that at least one storage element (e.g., the first storage element 110) of a memory die (e.g., the first memory die 104) has a characteristic indicative of an aging condition (e.g., the aging condition 128) during execution of the instructions by the processing module.", "Alternatively, or in addition, the memory operations may be performed responsive to determining that a temperature of the memory device is less than a first threshold and that the memory device satisfies the availability criterion.", "In a particular aspect, the operations include, prior to performing a memory access (e.g., the write request 534 or the read request 538) at a memory device (e.g., the memory device 103), determining that the memory device (e.g., the memory device 103) has a characteristic indicative of a temperature crossing (e.g., the temperature crossing condition 528).", "The operations also include, in response to the determination, increasing a temperature (e.g., the temperature 158) of the memory device (e.g., the memory device 103) by performing memory operations (e.g., the memory operations 166) at the memory device (e.g., the memory device 103) until detecting a condition related to the temperature (e.g., the temperature condition 526).", "In another particular aspect, the operations include in response to determining that a temperature of the memory device is less than a threshold, determining that the memory device satisfies an availability criterion.", "The operations also include in response to determining that the memory device satisfies the availability criterion, increasing the temperature of the memory device by performing memory operations at the memory device until detecting a condition related to the temperature.", "In this aspect, performing the memory operations may include sending an instruction to the memory device to initiate a set of memory operations.", "In a particular example, the operations may also include determining, based on the availability criterion, a number of memory operations of the set of memory operations.", "In this example, the number of memory operations of the set of memory operations may be determined such that a request to access the memory device that is received from a host device during performance of the memory operations can be satisfied.", "In yet another particular aspect, a device include a memory device and a controller.", "The controller is configured to perform memory operations on the memory device to heat the memory device to at least a threshold temperature when power demand of the memory device is less than a power threshold.", "In this particular aspect, heating the memory device may include performing a set of memory operations at the memory device, where a number of operations of the set of memory operations is determined based on the power threshold.", "The power threshold may be set such that a host request, received at the controller at a first time, can be satisfied when the power demand at the first time is less than or equal to the power threshold.", "In a particular example, the memory device may include a plurality of memory dies, and the power demand may be associated with a number of active dies of the plurality of memory dies.", "In this example, heating the memory device includes performing a set of memory operations at one or more idle memory dies of the plurality of memory dies.", "Although various components depicted herein are illustrated as block components and described in general terms, such components may include one or more microprocessors, state machines, or other circuits configured to enable such components to perform one or more operations described herein.", "For example, the temperature condition 126, the aging condition 128, or both, may represent physical components, such as hardware controllers, state machines, logic circuits, or other structures, to enable the healing engine 122 to detect the temperature condition 126, the aging condition 128, or both.", "As another example, the healing engine 122 may represent physical components, such as hardware controllers, state machines, logic circuits, or other structures, to enable the controller 120 to increase a temperature of a memory die (e.g., a first memory die 104) until the temperature condition 126 is detected.", "The temperature of the first memory die 104 may be increased responsive to determining that at least one storage element has a characteristic indicative of the aging condition 128.In a particular aspect, the temperature condition 526, the temperature crossing condition 528, or both, may represent physical components, such as hardware controllers, state machines, logic circuits, or other structures, to enable the temperature crossing engine 522 to detect the temperature condition 526, the temperature crossing condition 528, or both.", "In a particular aspect, the temperature crossing engine 522 may represent physical components, such as hardware controllers, state machines, logic circuits, or other structures, to enable the controller 120 to increase a temperature of a memory die (e.g., a first memory die 104) until the temperature condition 526 is detected.", "The temperature of the first memory die 104 may be increased, prior to performing a memory access (e.g., the write request 534 or the read request 538), responsive to determining that the first memory die 104 has a characteristic indicative of the temperature crossing condition 528.Alternatively or in addition, one or more components described herein may be implemented using a microprocessor or microcontroller programmed to perform operations, such as one or more operations of the method 300 of FIG.", "3, the method 400 of FIG.", "4, the method 800 of FIG.", "8, the method 900 of FIG.", "9, or a combination thereof.", "Instructions executed by the healing engine 122, the temperature crossing engine 522, the controller 120 and/or the device 102 may be retrieved from the memory 140 or from a separate memory location that is not part of the memory 140, such as from a read-only memory (ROM).", "In conjunction with one or more of the described aspects of FIGS.", "1-9, an apparatus includes means for communicating with a memory device that includes a plurality of memory dies.", "For example, the means for communicating may include or correspond to the interface 118 of FIG.", "1, one or more other structures, devices, circuits, modules, or a combination thereof.", "The apparatus also includes means for increasing the temperature of a first die of the plurality of memory dies by performing memory operations on the first die until detecting a condition related to the temperature.", "The means for increasing the temperature of the first die may include the healing engine 122 of FIG.", "1, one or more other structures, devices, circuits, modules, instructions for increasing the temperature of the first die, or a combination thereof.", "The temperature may be increased responsive to determining that at least one storage element of the first die has a characteristic indicative of an aging condition.", "The device 102 may be coupled to, attached to, or embedded within one or more access devices, such as within a housing of the device 504.For example, the device 102 may be embedded within the device 504 in accordance with a Joint Electron Devices Engineering Council (JEDEC) Solid State Technology Association Universal Flash Storage (UFS) configuration.", "To further illustrate, the device 102 may be integrated within an electronic device, such as a mobile telephone, a computer (e.g., a laptop, a tablet, or a notebook computer), a music player, a video player, a gaming device or console, a component of a vehicle (e.g., a vehicle console), an electronic book reader, a personal digital assistant (PDA), a portable navigation device, or other device that uses internal non-volatile memory.", "In one or more other implementations, the device 102 may be implemented in a portable device configured to be selectively coupled to one or more external devices, such as a host device (e.g., the device 504).", "For example, the device 102 may be removable from the device 504 (i.e., “removably” coupled to the device 504).", "As an example, the device 102 may be removably coupled to the device 504 in accordance with a removable universal serial bus (USB) configuration.", "In some implementations, the system 100, the system 500, the device 102, or the memory 140 may be integrated within a network-accessible data storage system, such as an enterprise data system, an NAS system, or a cloud data storage system, as illustrative examples.", "In some implementations, the device 102 may include a solid state drive (SSD).", "The device 102 may function as an embedded storage drive (e.g., an embedded SSD drive of a mobile device), an enterprise storage drive (ESD), a cloud storage device, a network-attached storage (NAS) device, or a client storage device, as illustrative, non-limiting examples.", "In some implementations, the device 102 may be coupled to another device (e.g., the device 504) via a network.", "For example, the network may include a data center storage system network, an enterprise storage system network, a storage area network, a cloud storage network, a local area network (LAN), a wide area network (WAN), the Internet, and/or another network.", "To further illustrate, the device 102 may be configured to be coupled to another device (e.g., the device 504) as embedded memory, such as in connection with an embedded MultiMedia Card (eMMC®) (trademark of JEDEC Solid State Technology Association, Arlington, Va.) configuration, as an illustrative example.", "The device 102 may correspond to an eMMC device.", "As another example, the device 102 may correspond to a memory card, such as a Secure Digital (SD®) card, a microSD® card, a miniSD™ card (trademarks of SD-3C LLC, Wilmington, Del.", "), a MultiMediaCard™ (MMC™) card (trademark of JEDEC Solid State Technology Association, Arlington, Va.), or a CompactFlash® (CF) card (trademark of SanDisk Corporation, Milpitas, Calif.).", "The device 102 may operate in compliance with a JEDEC industry specification.", "For example, the device 102 may operate in compliance with a JEDEC eMMC specification, a JEDEC Universal Flash Storage (UFS) specification, one or more other specifications, or a combination thereof.", "The memory 140 may include a resistive random access memory (ReRAM), a flash memory (e.g., a NAND memory, a NOR memory, a SLC flash memory, a MLC flash memory, a divided bit-line NOR (DINOR) memory, an AND memory, a high capacitive coupling ratio (HiCR) device, an asymmetrical contactless transistor (ACT) device, or another flash memory), an erasable programmable read-only memory (EPROM), an electrically-erasable programmable read-only memory (EEPROM), a read-only memory (ROM), a one-time programmable memory (OTP), another type of memory, or a combination thereof.", "In a particular embodiment, the device 102 is indirectly coupled to an access device via a network.", "For example, the device 102 may be a network-attached storage (NAS) device or a component (e.g., a solid-state drive (SSD) component) of a data center storage system, an enterprise storage system, or a storage area network.", "The memory 140 may include a semiconductor memory device.", "Semiconductor memory devices include volatile memory devices, such as dynamic random access memory (“DRAM”) or static random access memory (“SRAM”) devices, non-volatile memory devices, such as resistive random access memory (“ReRAM”), magnetoresistive random access memory (“MRAM”), electrically erasable programmable read only memory (“EEPROM”), flash memory (which can also be considered a subset of EEPROM), ferroelectric random access memory (“FRAM”), and other semiconductor elements capable of storing information.", "Each type of memory device may have different configurations.", "For example, flash memory devices may be configured in a NAND or a NOR configuration.", "The memory devices can be formed from passive and/or active elements, in any combinations.", "By way of non-limiting example, passive semiconductor memory elements include ReRAM device elements, which in some embodiments include a resistivity switching storage element, such as an anti-fuse, phase change material, etc., and optionally a steering element, such as a diode, etc.", "Further by way of non-limiting example, active semiconductor memory elements include EEPROM and flash memory device elements, which in some embodiments include elements containing a charge region, such as a floating gate, conductive nanoparticles, or a charge storage dielectric material.", "Multiple memory elements may be configured so that they are connected in series or so that each element is individually accessible.", "By way of non-limiting example, flash memory devices in a NAND configuration (NAND memory) typically contain memory elements connected in series.", "A NAND memory array may be configured so that the array is composed of multiple strings of memory in which a string is composed of multiple memory elements sharing a single bit line and accessed as a group.", "Alternatively, memory elements may be configured so that each element is individually accessible, e.g., a NOR memory array.", "NAND and NOR memory configurations are exemplary, and memory elements may be otherwise configured.", "The semiconductor memory elements located within and/or over a substrate may be arranged in two or three dimensions, such as a two dimensional memory structure or a three dimensional memory structure.", "In a two dimensional memory structure, the semiconductor memory elements are arranged in a single plane or a single memory device level.", "Typically, in a two dimensional memory structure, memory elements are arranged in a plane (e.g., in an x-z direction plane) which extends substantially parallel to a major surface of a substrate that supports the memory elements.", "The substrate may be a wafer over or in which the layer of the memory elements are formed or it may be a carrier substrate which is attached to the memory elements after they are formed.", "As a non-limiting example, the substrate may include a semiconductor such as silicon.", "The memory elements may be arranged in the single memory device level in an ordered array, such as in a plurality of rows and/or columns.", "However, the memory elements may be arrayed in non-regular or non-orthogonal configurations.", "The memory elements may each have two or more electrodes or contact lines, such as bit lines and word lines.", "A three dimensional memory array is arranged so that memory elements occupy multiple planes or multiple memory device levels, thereby forming a structure in three dimensions (i.e., in the x, y and z directions, where they direction is substantially perpendicular and the x and z directions are substantially parallel to the major surface of the substrate).", "As a non-limiting example, a three dimensional memory structure may be vertically arranged as a stack of multiple two dimensional memory device levels.", "As another non-limiting example, a three dimensional memory array may be arranged as multiple vertical columns (e.g., columns extending substantially perpendicular to the major surface of the substrate, i.e., in they direction) with each column having multiple memory elements in each column.", "The columns may be arranged in a two dimensional configuration, e.g., in an x-z plane, resulting in a three dimensional arrangement of memory elements with elements on multiple vertically stacked memory planes.", "Other configurations of memory elements in three dimensions can also constitute a three dimensional memory array.", "By way of non-limiting example, in a three dimensional NAND memory array, the memory elements may be coupled together to form a NAND string within a single horizontal (e.g., x-z) memory device levels.", "Alternatively, the memory elements may be coupled together to form a vertical NAND string that traverses across multiple horizontal memory device levels.", "Other three dimensional configurations can be envisioned wherein some NAND strings contain memory elements in a single memory level while other strings contain memory elements which span through multiple memory levels.", "Three dimensional memory arrays may also be designed in a NOR configuration and in a ReRAM configuration.", "Typically, in a monolithic three dimensional memory array, one or more memory device levels are formed above a single substrate.", "Optionally, the monolithic three dimensional memory array may also have one or more memory layers at least partially within the single substrate.", "As a non-limiting example, the substrate may include a semiconductor such as silicon.", "In a monolithic three dimensional array, the layers constituting each memory device level of the array are typically formed on the layers of the underlying memory device levels of the array.", "However, layers of adjacent memory device levels of a monolithic three dimensional memory array may be shared or have intervening layers between memory device levels.", "Alternatively, two dimensional arrays may be formed separately and then packaged together to form a non-monolithic memory device having multiple layers of memory.", "For example, non-monolithic stacked memories can be constructed by forming memory levels on separate substrates and then stacking the memory levels atop each other.", "The substrates may be thinned or removed from the memory device levels before stacking, but as the memory device levels are initially formed over separate substrates, the resulting memory arrays are not monolithic three dimensional memory arrays.", "Further, multiple two dimensional memory arrays or three dimensional memory arrays (monolithic or non-monolithic) may be formed on separate chips and then packaged together to form a stacked-chip memory device.", "Associated circuitry is typically used for operation of the memory elements and for communication with the memory elements.", "As non-limiting examples, memory devices may have circuitry used for controlling and driving memory elements to accomplish functions such as programming and reading.", "This associated circuitry may be on the same substrate as the memory elements and/or on a separate substrate.", "For example, a controller for memory read-write operations may be located on a separate controller chip and/or on the same substrate as the memory elements.", "One of skill in the art will recognize that this disclosure is not limited to the two dimensional and three dimensional exemplary structures described but cover all relevant memory structures within the spirit and scope of the disclosure as described herein and as understood by one of skill in the art.", "The illustrations of the embodiments described herein are intended to provide a general understanding of the various embodiments.", "Other embodiments may be utilized and derived from the disclosure, such that structural and logical substitutions and changes may be made without departing from the scope of the disclosure.", "This disclosure is intended to cover any and all subsequent adaptations or variations of various embodiments.", "Those of skill in the art will recognize that such modifications are within the scope of the present disclosure.", "The above-disclosed subject matter is to be considered illustrative, and not restrictive, and the appended claims are intended to cover all such modifications, enhancements, and other embodiments, that fall within the scope of the present disclosure.", "Thus, to the maximum extent allowed by law, the scope of the present disclosure is to be determined by the broadest permissible interpretation of the following claims and their equivalents, and shall not be restricted or limited by the foregoing detailed description." ] ]
Patent_15876119
[ [ "COMPOSITION OF MATTER AND USE THEREOF", "Embodiments of the disclosure pertain to a composition of matter having a matrix, a thickener, a strengthener, and a soluble medium.", "The matrix may be about 100 parts by weight of a low viscosity cycloaliphatic epoxy resin with an anhydride curing agent.", "The thickener may be about 10-20 parts by weight of an additive comprising a clay.", "The strengthener may be about 5-10 parts by weight of a glass.", "The soluble medium may be about 20-30 parts by weight of a water-soluble fiber." ], [ "1.A composition of matter comprising: an epoxy system comprising an epoxy resin and a hardener; an additive comprising a clay; a soluble medium; and a glass.", "2.The composition of claim 1, wherein the soluble medium comprises a plurality of soluble fibers, wherein the clay comprises modified montmorillonite, wherein the glass comprises high-strength, hollow glass microspheres with an average diameter of about 20 to about 25 microns, and wherein the hardener comprises an anhydride.", "3.The composition of claim 2, wherein the plurality of soluble fibers comprises sodium polyacrylate fibers, and the length is in the range of about 0.5 mm to about 2 mm.", "4.The composition of claim 1, wherein the epoxy system comprises about 100 parts by weight, wherein the epoxy resin comprises a low viscosity cycloaliphatic epoxy resin, wherein the hardener comprises an anhydride curing agent, wherein the additive comprises about 10-20 parts by weight, wherein the soluble medium comprises about 20-30 parts by weight, and further comprises a plurality of water-soluble fibers, wherein the glass comprises about 5-10 parts by weight, and wherein the glass comprises hollow glass spheres.", "5.The composition of claim 4, wherein the clay comprises modified montmorillonite, wherein the hollow glass microspheres comprise an average diameter of about 20 to about 25 microns, wherein the plurality of soluble fibers comprises sodium polyacrylate fibers, and the length is in the range of about 0.5 mm to about 2 mm.", "6.A composition of matter comprising: 100 parts by weight of a low viscosity cycloaliphatic epoxy resin with an anhydride curing agent; 10-20 parts by weight of an additive comprising a clay; 20-30 parts by weight of a plurality of water-soluble fibers; and 5-10 parts by weight of a glass.", "6.The composition of claim 5, wherein the clay comprises montmorillonite, wherein the glass comprises hollow-glass microspheres, and wherein the plurality of soluble fibers comprise a fiber length of less than 6 mm 7.The composition of claim 6, wherein the plurality of soluble fibers comprises sodium polyacrylate fibers.", "8.The composition of claim 5, wherein the clay comprises montmorillonite, wherein the glass comprises high-strength, hollow glass microspheres with an average diameter of about 20 to about 25 microns, wherein the plurality of soluble fibers comprises sodium polyacrylate fibers, and a length of each of the plurality of soluble fibers is in the range of about 0.5 mm to about 2 mm.", "9.A method of curing a composition, the method comprising: heating an oven to an inner oven temperature in the range of about 70° F. to about 100° F.; placing the composition into the oven; heating the oven with a ramp up about 0.2-2° F./min to a next inner oven temperature in a first predetermined range of about 120° F. to about 200° F.; holding the oven in the first predetermined range for a first predetermined amount of soak time of about 30 minutes to about 120 minutes; heating the oven with a ramp up about 0.2-2° F./min to a second inner oven temperature in a second predetermined range of about 160° F. to about 250° F.; heating the oven with a ramp up about 1-4° F./min to a third inner oven temperature in a third predetermined range of about 250° F. to about 350° F.; holding the oven in the third predetermined range for about 30 minutes to about 120 minutes; and cooling the oven with a ramp down at a rate of about 0.2-2° F./min to a temperature in the range of about 70° F. to about 100° F. 10.The method of claim 9, wherein the composition comprises: an epoxy system comprising an epoxy resin and a hardener; an additive comprising a clay; a soluble medium; and a glass.", "11.The method of claim 9, wherein the method comprises: 100 parts by weight of a low viscosity cycloaliphatic epoxy resin with an anhydride curing agent; about 10-20 parts by weight of an additive comprising clay; about 20-30 parts by weight of a water-soluble fiber; and about 5-10 parts by weight of a glass.", "12.A composition of matter comprising: 100 parts by weight of a low viscosity cycloaliphatic epoxy resin with an anhydride curing agent; about 10-20 parts by weight of an additive comprising a clay; about 20-30 parts by weight of a water-soluble fiber; and about 5-10 parts by weight of a glass.", "13.The composition of claim 12, wherein the water-soluble fiber comprises sodium polyacrylate fibers having a fiber length in the range of about 0.5 to about 6 mm.", "14.The composition of claim 13, wherein the glass comprises high-strength, hollow-glass spheres of an average diameter of 22 microns.", "15.The composition of claim 12, wherein the clay comprises montmorillonite, wherein the glass comprises hollow-glass microspheres, and wherein the water-soluble fiber comprises sodium polyacrylate fibers having a fiber length in the range of about 0.5 to about 6 mm.", "16.The composition of claim 12, wherein the clay comprises montmorillonite, wherein the glass comprises high-strength, hollow glass microspheres with an average diameter of about 20 to about 25 microns, wherein the water-soluble fiber comprises sodium polyacrylate fibers, and a length of each of the plurality of soluble fibers is in the range of about 0.5 mm to about 2 mm." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>Embodiments of the disclosure pertain to a composition of matter that may include in the range of: about 100 parts by weight of a resin system; about 10-20 parts by weight of a clay; about 20-30 parts by weight of a fiber; and about 5-10 parts by weight of a glass.", "The resin system may include a low viscosity cycloaliphatic epoxy resin with an anhydride curing agent.", "The clay may include or be bentonite.", "The clay may include or be montmorillonite.", "The clay may be modified montmorillonite.", "The glass may include or be glass spheres.", "The composition may include at least one of organic hemp fiber, glass fiber, and combinations thereof.", "The composition may include a water-soluble material.", "In aspects, the water-soluble material may include or be one of a salt, a sugar, and combinations thereof.", "The glass may include or be high-strength, hollow-glass spheres of an average diameter of 22 microns.", "The composition may include a water-soluble fiber.", "In aspects, the water-soluble fiber may include or be sodium polyacrylate.", "Embodiments of the disclosure pertain to a device that may have (or being made from a material that may have) any composition of matter disclosed herein.", "The device may be selected from one of a downhole tool, a component of the downhole tool, and a frac ball.", "The device may be made from a cured composition.", "Embodiments of the disclosure pertain to a device for use in a downhole environment that may have (or being made from a material, including cured material, that may have) any composition of matter disclosed herein.", "Embodiments of the disclosure pertain to an apparatus that may have (or being made from a material, including cured material, that may have) any composition of matter disclosed herein.", "Embodiments of the disclosure pertain to a downhole tool with one or more components that may have (or being made from a material, including cured material, that may have) any composition of matter disclosed herein.", "Embodiments of the disclosure pertain to a frac ball that may have (or being made from a material, including cured material, that may have) any composition of matter disclosed herein.", "The material may include a composition of an anhydride-based cure resin and a flexibilizer comprising clay.", "The material may include a composition of an anhydride epoxy resin system and a thixotropic rheology modifier comprising clay.", "The material may degrade at 0.24-17 g/hr at various temperatures.", "The material may degrade within 24 hours of activation.", "The clay may include a nano-clay and/or clay particles The material may include polyglycolic acid.", "Any number of devices, tools, and other components may be made of materials disclosed herein.", "The material may be or result in a cured material, whereby one or more of the original constituents undergo some amount of change The material may include a sugar-based epoxy.", "A downhole tool made of a material of the present disclosure.", "A downhole tool configured with one or more components made of a material of the present disclosure, or a cured byproduct thereof.", "A device made of a material of the present disclosure, or a cured byproduct thereof.", "A frac ball made of a material of the present disclosure, or a cured byproduct thereof.", "A composition as disclosed herein further including a sugar-based epoxy.", "The material may include a resin.", "The resin may be an anhydride-cured epoxy resin material.", "It may be possible to use sodium polyacrylate fiber in conjunction therewith, although any fiber that has dissolvable properties associated with it may be used.", "Resins described herein may include a flexibilizer distributed therewith.", "A flexibilizer may include clay(s), hygroscopic clay, nano-clay, bentonite, or any other material that is easily distributable within the resin and reduces brittleness of the resin.", "Carbon nano-tubes may also add strength but promote capillary water flow through the resin matrix.", "Embodiments of the disclosure pertain to a device that may have (or being made from a material that may have) any composition of matter disclosed herein, or a cured byproduct thereof.", "The device may be selected from the group consisting of a downhole tool, a component of the downhole tool, and a frac ball.", "Embodiments of the disclosure pertain to a device for use in a downhole environment that may have (or being made from a material that may have) any composition of matter disclosed herein, or a cured byproduct thereof.", "Embodiments of the disclosure pertain to an apparatus that may have (or being made from a material that may have) any composition of matter disclosed herein, or a cured byproduct thereof.", "Embodiments of the disclosure pertain to a downhole tool with one or more components that may have (or being made from a material that may have) any composition of matter disclosed herein, or a cured byproduct thereof.", "Embodiments of the disclosure pertain to a frac ball that may have (or being made from a material that may have) any composition of matter disclosed herein, or a cured byproduct thereof.", "These and other embodiments, features and advantages will be apparent in the following detailed description and drawings." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a ‘bypass’ continuation of PCT Application Ser.", "No.", "PCT/US17/40611, filed on Jul.", "3, 2017, which claims priority to: U.S.", "Provisional Patent Application Ser.", "No.", "62/439,085, filed on Dec. 26, 2016, and U.S.", "Provisional Patent Application Ser.", "No.", "62/358,230, filed on Jul.", "5, 2016.The disclosure of each application is hereby incorporated herein by reference in its entirety for all purposes.", "STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT Not applicable.", "BACKGROUND Field of the Disclosure This disclosure generally relates to systems and related tools used in oil and gas wellbores.", "Certain embodiments pertain to a composition of matter useable with systems, related tools, and parts thereof.", "Particular embodiments of the disclosure pertain to a breakable, dissolvable, disassociatable, and/or degradable material.", "Some embodiments include a material(s) having a composition of about 100 parts by weight of a resin system that includes an epoxy resin with an anhydride hardener; about 10-20 parts by weight of an additive that may be a clay-based constituent; about 20-30 parts by weight of a fiber; and about 5-10 parts by weight of a glass.", "The epoxy resin may be a low viscosity cycloaliphatic epoxy resin.", "Background of the Disclosure An oil or gas well includes a wellbore extending into a subterranean formation at some depth below a surface (e.g., Earth's surface), and is usually lined with a tubular, such as casing, to add strength to the well.", "Many commercially viable hydrocarbon sources are found in “tight” reservoirs, which means the target hydrocarbon product may not be easily extracted.", "The surrounding formation (e.g., shale) to these reservoirs typically has low permeability, and it is uneconomical to produce the hydrocarbons (i.e., gas, oil, etc.)", "in commercial quantities from this formation without the use of drilling accompanied with additional operations.", "Fracing is common in the industry and includes the use of a plug set in the wellbore below or beyond the respective target zone, followed by pumping or injecting high pressure frac fluid into the zone.", "A frac plug and accompanying operation may be such as described or otherwise disclosed in U.S. Pat.", "No.", "8,955,605, incorporated by reference herein in its entirety for all purposes.", "Still, downhole operations may include the use of any number of other devices, tools, etc.", "(or collectively in general a “tool” or “tools”) including drill bits, flow controllers, packers, plugs, sliding sleeves, related tubing, and more.", "Some tools may be characterized as having complex mechanical designs, and often require remote control or actuation from the surface via wirelines, hydraulic control lines, coil tubings, and so forth.", "Other methods of actuation include pressurization, which may occur by sliding a sleeve or dropping a ball in order to block or otherwise obstruct an orifice in the tool.", "Downhole tools typically have multiple components constructed of steel, cast iron, aluminum, or other alloyed metals.", "Additionally, or alternatively, tool components may include composite or rubber materials.", "It is naturally desirable to “flow back,” i.e., from the formation to the surface, the injected fluid, or the formation fluid(s); however, this is not possible until the previously set tool or its blockage is removed.", "Removal of tools (or blockage) usually requires a well-intervention service for retrieval or drill-through, which is time consuming, costly, and adds a potential risk of wellbore damage.", "The more metal parts used in the tool, the longer the drill-through operation takes.", "Because metallic components are harder to drill, such an operation may require additional trips into and out of the wellbore to replace worn out drill bits.", "In the interest of cost-saving, materials that react under certain downhole conditions have been the subject of significant research in view of the potential offered to the oilfield industry.", "For example, such an advanced material that has an ability to degrade by mere response to a change in its surrounding is desirable because no, or limited, intervention would be necessary for removal or actuation to occur.", "Such a material, essentially self-actuated by changes in its surrounding (e.g., the presence a specific fluid, a change in temperature, and/or a change in pressure, etc.)", "may potentially replace costly and complicated designs and may be most advantageous in situations where accessibility is limited or even considered to be impossible, which is the case in a downhole (subterranean) environment.", "It is highly desirable and economically advantageous to have controls that do not rely on lengthy and costly wirelines, hydraulic control lines, or coil tubings.", "Furthermore, in countless situations, a subterranean piece of equipment may need to be actuated only once, after which it may no longer present any usefulness, and may even become disadvantageous when for instance the equipment must be retrieved by risky and costly interventions.", "In some instances, it may be advantageous to have a device (ball, tool, component, etc.)", "made of a material (of composition of matter) characterized by properties where the device is mechanically strong (hard) under some conditions (such as at the surface or at ambient conditions), but degrades, dissolves, breaks, etc.", "under specific conditions, such as in the presence of water-containing fluids like fresh water, seawater, formation fluid, additives, brines, acids and bases, or changes in pressure and/or temperature.", "Thus, after a predetermined amount of time, and after the desired operation(s) is complete, the formation fluid is ultimately allowed to flow toward the surface.", "It would be advantageous to configure a device (or a related activation device, such as a frac ball, or other component(s)) to utilize materials that alleviate or reduce the need for an intervention service.", "This would save a considerable amount of time and expense.", "Therefore, there is a need in the art for tools, devices, components, etc.", "to be of a nature that does not involve or otherwise require a drill-through process.", "Environmental- or bio-friendly materials are further desirous.", "The ability to save operational time (and those saving operational costs) leads to considerable competition in the marketplace.", "Achieving any ability to save time, or ultimately cost, leads to an immediate competitive advantage.", "SUMMARY Embodiments of the disclosure pertain to a composition of matter that may include in the range of: about 100 parts by weight of a resin system; about 10-20 parts by weight of a clay; about 20-30 parts by weight of a fiber; and about 5-10 parts by weight of a glass.", "The resin system may include a low viscosity cycloaliphatic epoxy resin with an anhydride curing agent.", "The clay may include or be bentonite.", "The clay may include or be montmorillonite.", "The clay may be modified montmorillonite.", "The glass may include or be glass spheres.", "The composition may include at least one of organic hemp fiber, glass fiber, and combinations thereof.", "The composition may include a water-soluble material.", "In aspects, the water-soluble material may include or be one of a salt, a sugar, and combinations thereof.", "The glass may include or be high-strength, hollow-glass spheres of an average diameter of 22 microns.", "The composition may include a water-soluble fiber.", "In aspects, the water-soluble fiber may include or be sodium polyacrylate.", "Embodiments of the disclosure pertain to a device that may have (or being made from a material that may have) any composition of matter disclosed herein.", "The device may be selected from one of a downhole tool, a component of the downhole tool, and a frac ball.", "The device may be made from a cured composition.", "Embodiments of the disclosure pertain to a device for use in a downhole environment that may have (or being made from a material, including cured material, that may have) any composition of matter disclosed herein.", "Embodiments of the disclosure pertain to an apparatus that may have (or being made from a material, including cured material, that may have) any composition of matter disclosed herein.", "Embodiments of the disclosure pertain to a downhole tool with one or more components that may have (or being made from a material, including cured material, that may have) any composition of matter disclosed herein.", "Embodiments of the disclosure pertain to a frac ball that may have (or being made from a material, including cured material, that may have) any composition of matter disclosed herein.", "The material may include a composition of an anhydride-based cure resin and a flexibilizer comprising clay.", "The material may include a composition of an anhydride epoxy resin system and a thixotropic rheology modifier comprising clay.", "The material may degrade at 0.24-17 g/hr at various temperatures.", "The material may degrade within 24 hours of activation.", "The clay may include a nano-clay and/or clay particles The material may include polyglycolic acid.", "Any number of devices, tools, and other components may be made of materials disclosed herein.", "The material may be or result in a cured material, whereby one or more of the original constituents undergo some amount of change The material may include a sugar-based epoxy.", "A downhole tool made of a material of the present disclosure.", "A downhole tool configured with one or more components made of a material of the present disclosure, or a cured byproduct thereof.", "A device made of a material of the present disclosure, or a cured byproduct thereof.", "A frac ball made of a material of the present disclosure, or a cured byproduct thereof.", "A composition as disclosed herein further including a sugar-based epoxy.", "The material may include a resin.", "The resin may be an anhydride-cured epoxy resin material.", "It may be possible to use sodium polyacrylate fiber in conjunction therewith, although any fiber that has dissolvable properties associated with it may be used.", "Resins described herein may include a flexibilizer distributed therewith.", "A flexibilizer may include clay(s), hygroscopic clay, nano-clay, bentonite, or any other material that is easily distributable within the resin and reduces brittleness of the resin.", "Carbon nano-tubes may also add strength but promote capillary water flow through the resin matrix.", "Embodiments of the disclosure pertain to a device that may have (or being made from a material that may have) any composition of matter disclosed herein, or a cured byproduct thereof.", "The device may be selected from the group consisting of a downhole tool, a component of the downhole tool, and a frac ball.", "Embodiments of the disclosure pertain to a device for use in a downhole environment that may have (or being made from a material that may have) any composition of matter disclosed herein, or a cured byproduct thereof.", "Embodiments of the disclosure pertain to an apparatus that may have (or being made from a material that may have) any composition of matter disclosed herein, or a cured byproduct thereof.", "Embodiments of the disclosure pertain to a downhole tool with one or more components that may have (or being made from a material that may have) any composition of matter disclosed herein, or a cured byproduct thereof.", "Embodiments of the disclosure pertain to a frac ball that may have (or being made from a material that may have) any composition of matter disclosed herein, or a cured byproduct thereof.", "These and other embodiments, features and advantages will be apparent in the following detailed description and drawings.", "BRIEF DESCRIPTION OF THE DRAWINGS For a more detailed description of the present disclosure, reference will now be made to the accompanying drawings, wherein: FIG.", "1 is a side view of a process diagram of a conventional plugging system; FIG.", "2A shows an isometric view of a system having a downhole tool, according to embodiments of the disclosure; FIG.", "2B shows an isometric view of the downhole tool of FIG.", "2A positioned within a tubular, according to embodiments of the disclosure; FIG.", "2C shows a side longitudinal view of a downhole tool according to embodiments of the disclosure; FIG.", "2D shows a longitudinal cross-sectional view of a downhole tool according to embodiments of the disclosure; FIG.", "2E shows an isometric component break-out view of a downhole tool according to embodiments of the disclosure; FIG.", "3A shows a longitudinal cross-sectional view of a downhole tool with a hybrid sleeve according to embodiments of the disclosure; FIG.", "3B shows a longitudinal cross-sectional view of the tool of FIG.", "3A with a dissolved sleeve insert according to embodiments of the disclosure; FIG.", "3C shows an isometric component breakout view of a downhole tool with a hybrid sleeve according to embodiments of the disclosure; and FIG.", "3D shows an isometric component breakout view of a system using a downhole tool with a hybrid sleeve according to embodiments of the disclosure.", "DETAILED DESCRIPTION Herein disclosed are novel compositions of matter useable with apparatuses, systems, and methods that pertain to downhole tools for wellbore operations, details of which are described herein.", "Embodiments herein may pertain to a downhole tool suitable for use in a wellbore that may include a mandrel sleeve; and a sleeve insert disposed within the mandrel sleeve.", "The tool may have a first slip disposed about the mandrel sleeve.", "There may be a second slip disposed about the mandrel sleeve.", "The second slip may be proximate to a conical surface.", "There may be a lower sleeve engaged with the second slip.", "The mandrel sleeve may include a set of threads.", "At least one of the first slip and the second slip may have a one-piece configuration with at least partial connectivity around the entirety of a circular slip body.", "Either of the slips may be made of a composite material.", "Either of the slips may be made of metal.", "Either of the slips may be surface hardened.", "The downhole tool may include a seal element.", "The tool may include a composite member disposed about the mandrel.", "The composite member may be in engagement with the seal element.", "The composite member may be made of a first material and comprises a first portion and a second portion.", "The first material may be a composite material, such as filament wound material.", "The first portion may be a deformable portion.", "The second portion may be a resilient portion.", "The tool may include a seal element positioned on the mandrel sleeve and in between a first cone and a second cone.", "The first cone may be proximate to the first slip, and/or the second cone may be proximate to the second slip.", "There may be a bearing plate disposed around the mandrel sleeve.", "In aspects, the set of threads may be one of shear threads and rounded threads.", "In aspects, the mandrel sleeve may be made of non-dissolvable composite material.", "In aspects, the sleeve insert may be made of dissolvable material.", "In other aspects, the sleeve insert may be configured to dissolve or have some other change in physical characteristic within 24 hours of setting the downhole tool.", "The sleeve insert may be made of, or otherwise include, an anhydride cure resin.", "Embodiments herein pertain to a downhole tool for use in a wellbore that may include a mandrel sleeve having at least one set of threads; and a sleeve insert threadingly engaged with the mandrel sleeve.", "The tool may further include a first slip disposed about the mandrel, the first slip further comprising a circular slip body; a second slip disposed about the mandrel; a lower sleeve engaged with the second slip; a seal element; and a bearing plate.", "Either of the slips may have a one-piece configuration with at least partial connectivity around the entirety of a respective circular slip body, and at least two grooves disposed therein.", "In aspects, the sleeve insert may be made of, or otherwise include, a dissolvable resin.", "The sleeve insert may be made of, or otherwise include, a resin comprising a flexibilizer.", "The flexibilizer may be or otherwise include clay.", "The flexibilizer may be or otherwise include nanoclay.", "The flexibilizer may be or otherwise include clay particles.", "The sleeve insert may be made of or otherwise include bentonite.", "In aspects, the sleeve insert may be made of, or otherwise include, a dissolvable resin.", "The sleeve insert may be made of, or otherwise include, a resin comprising a thixotropic rheology modifier.", "The thixotropic rheology modifier may be or otherwise include clay.", "Terms Composition of matter: as used herein may refer to one or more ingredients or constituents that make up a material (or material of construction).", "For example, a material may have a composition of matter.", "Similarly, a device may be made of a material having a composition of matter, or a cured byproduct thereof.", "Degradable Material: as used herein may refer to a composition of matter (including a cured byproduct thereof) having properties and/or characteristics that, while subject to change over time and/or under certain conditions, lead to a change in the integrity of the material.", "As one example, the material may initially be hard, rigid, and strong at ambient or surface conditions, but over time (such as within about 12-36 hours) and under certain conditions (such as wellbore conditions), the material softens.", "Dissolvable Material: analogous to degradable material; as used herein may refer to a composition of matter (including a cured byproduct thereof) having properties and/or characteristics that, while subject to change over time and/or under certain conditions, lead to a change in the integrity of the material, including to the point of degrading, or partial or complete dissolution.", "As one example, the material may initially be hard, rigid, and strong at ambient or surface conditions, but over time (such as within about 12-36 hours) and under certain conditions (such as wellbore conditions), the material softens.", "As another example, the material may initially be hard, rigid, and strong at ambient or surface conditions, but over time (such as within about 12-36 hours) and under certain conditions (such as wellbore conditions), the material dissolves at least partially, and may dissolve completely.", "Breakable Material: as used herein may refer to a composition of matter (including a cured byproduct thereof) having properties and/or characteristics that, while subject to change over time and/or under certain conditions, lead to brittleness.", "As one example, the material may be hard, rigid, and strong at ambient or surface conditions, but over time and under certain conditions, becomes brittle.", "The breakable material may experience breakage into multiple pieces, but not necessarily dissolution.", "Disassociatable Material: as used herein may refer to a composition of matter (including a cured byproduct thereof) having properties and/or characteristics that, while subject to change over time and/or under certain conditions, lead to a change in the integrity of the material, including to the point of changing from a solid structure to a powdered material.", "As one example, the material may initially be hard, rigid, and strong at ambient or surface conditions, but over time (such as within about 12-36 hours) and under certain conditions (such as wellbore conditions), the material changes (disassociates) to a powder.", "For some embodiments, the material of construction may include a composition of matter (including a cured byproduct thereof) designed or otherwise having the inherent characteristic to change integrity or other physical attribute when exposed to certain wellbore conditions, such as a change in time, temperature, water, heat, pressure, solution, combinations thereof, etc.", "Heat may be present due to the temperature increase attributed to the natural temperature gradient of the earth, and water may already be present in existing wellbore fluids.", "The change in integrity may occur in a predetermined time period, which may vary from several minutes to several weeks.", "In aspects, the time period may be about 12 to about 36 hours.", "In some embodiments, the material may degrade to the point of ‘mush’ or disassociate to a powder, while in other embodiments, the material may dissolve or otherwise disintegrate and be carried away by fluid flowing in the wellbore.", "The temperature of the downhole fluid may affect the rate change in integrity.", "The material need not form a solution when it dissolves in the aqueous phase.", "For example, the material may dissolve, break, or otherwise disassociate into sufficiently small particles (i.e., a colloid), that may be removed by the fluid as it circulates in the well.", "In embodiments, the material may become degradable, but not dissolvable.", "In other embodiments, the material may become degradable, and subsequently dissolvable.", "In still other embodiments, the material may become breakable (or brittle), but not dissolvable.", "In yet other embodiments, the material may become breakable, and subsequently dissolvable.", "In still yet other embodiments, the material may disassociate.", "Referring now to FIGS.", "2A and 2B together, isometric views of a system 200 having a downhole tool 202 illustrative of embodiments disclosed herein, are shown.", "FIG.", "2B depicts a wellbore 206 formed in a subterranean formation 210 with a tubular 208 disposed therein.", "In an embodiment, the tubular 208 may be casing (e.g., casing, hung casing, casing string, etc.)", "(which may be cemented).", "A workstring 212 (which may include a part 217 of a setting tool coupled with adapter 252) may be used to position or run the downhole tool 202 into and through the wellbore 206 to a desired location.", "In accordance with embodiments of the disclosure, the tool 202 may be configured as a plugging tool, which may be set within the tubular 208 in such a manner that the tool 202 forms a fluid-tight seal against the inner surface 207 of the tubular 208.In an embodiment, the downhole tool 202 may be configured as a bridge plug, whereby flow from one section of the wellbore 213 to another (e.g., above and below the tool 202) is controlled.", "In other embodiments, the downhole tool 202 may be configured as a frac plug, where flow into one section 213 of the wellbore 206 may be blocked and otherwise diverted into the surrounding formation or reservoir 210.In yet other embodiments, the downhole tool 202 may also be configured as a ball-drop tool.", "In this aspect, a ball may be dropped into the wellbore 206 and flowed into the tool 202 and come to rest in a corresponding ball seat at the end of the mandrel 214.The seating of the ball may provide a seal within the tool 202 resulting in a plugged condition, whereby a pressure differential across the tool 202 may result.", "The ball seat may include a radius or curvature.", "In other embodiments, the downhole tool 202 may be a ball-check plug, whereby the tool 202 is configured with a ball already in place when the tool 202 runs into the wellbore.", "The tool 202 may then act as a check valve, and provide one-way flow capability.", "Fluid may be directed from the wellbore 206 to the formation with any of these configurations.", "Once the tool 202 reaches the set position within the tubular, the setting mechanism or workstring 212 may be detached from the tool 202 by various methods, resulting in the tool 202 left in the surrounding tubular and one or more sections of the wellbore isolated.", "In an embodiment, once the tool 202 is set, tension may be applied to the adapter 252 until the threaded connection between the adapter 252 and the mandrel 214 is broken.", "For example, the mating threads on the adapter 252 and the mandrel 214 (256 and 216, respectively as shown in FIG.", "2D) may be designed to shear, and thus may be pulled and sheared accordingly in a manner known in the art.", "The amount of load applied to the adapter 252 may be in the range of about, for example, 20,000 to 40,000 pounds force.", "In other applications, the load may be in the range of less than about 10,000 pounds force.", "Accordingly, the adapter 252 may separate or detach from the mandrel 214, resulting in the workstring 212 being able to separate from the tool 202, which may be at a predetermined moment.", "The loads provided herein are non-limiting and are merely exemplary.", "The setting force may be determined by specifically designing the interacting surfaces of the tool and the respective tool surface angles.", "The tool 202 may also be configured with a predetermined failure point (not shown) configured to fail or break.", "For example, the failure point may break at a predetermined axial force greater than the force required to set the tool but less than the force required to part the body of the tool.", "Operation of the downhole tool 202 may allow for fast run in of the tool 202 to isolate one or more sections of the wellbore 206, as well as quick and simple drill-through to destroy or remove the tool 202.Drill-through of the tool 202 may be facilitated by components and sub-components of tool 202 made of drillable material that is less damaging to a drill bit than those found in conventional plugs.", "In an embodiment, the downhole tool 202 and/or its components may be a drillable tool made from drillable composite material(s), such as glass fiber/epoxy, carbon fiber/epoxy, glass fiber/PEEK, carbon fiber/PEEK, etc.", "Other resins may include phenolic, polyamidic, etc.", "All mating surfaces of the downhole tool 202 may be configured with an angle, such that corresponding components may be placed under compression instead of shear.", "Referring now to FIGS.", "2C-2E together, a longitudinal view, a longitudinal cross-sectional view, and an isometric component break-out view, respectively, of downhole tool 202 useable with system (200, FIG.", "2A) and illustrative of embodiments disclosed herein, are shown.", "The downhole tool 202 may include a mandrel 214 that extends through the tool (or tool body) 202.The mandrel 214 may be a solid body.", "In other aspects, the mandrel 214 may include a flowpath or bore 250 formed therein (e.g., an axial bore).", "The bore 250 may extend partially or for a short distance through the mandrel 214, as shown in FIG.", "2E.", "Alternatively, the bore 250 may extend through the entire mandrel 214, with an opening at its proximate end 248 and oppositely at its distal end 246 (near downhole end of the tool 202), as illustrated by FIG.", "2D.", "The presence of the bore 250 or other flowpath through the mandrel 214 may indirectly be dictated by operating conditions.", "That is, in most instances the tool 202 may be large enough in diameter (e.g., 4-¾ inches) that the bore 250 may be correspondingly large enough (e.g., 1-¼ inches) so that debris and junk can pass or flow through the bore 250 without plugging concerns.", "However, with the use of a smaller diameter tool 202, the size of the bore 250 may need to be correspondingly smaller, which may result in the tool 202 being prone to plugging.", "Accordingly, the mandrel may be made solid to alleviate the potential of plugging within the tool 202.With the presence of the bore 250, the mandrel 214 may have an inner bore surface 247, which may include one or more threaded surfaces formed thereon.", "As such, there may be a first set of threads 216 configured for coupling the mandrel 214 with corresponding threads 256 of a setting adapter 252.The coupling of the threads, which may be shear threads, may facilitate detachable connection of the tool 202 and the setting adapter 252 and/or workstring (212, FIG.", "2B) at the threads.", "It is within the scope of the disclosure that the tool 202 may also have one or more predetermined failure points (not shown) configured to fail or break separately from any threaded connection.", "The failure point may fail or shear at a predetermined axial force greater than the force required to set the tool 202.The adapter 252 may include a stud 253 configured with the threads 256 thereon.", "In an embodiment, the stud 253 has external (male) threads 256 and the mandrel 214 has internal (female) threads; however, type or configuration of threads is not meant to be limited, and could be, for example, a vice versa female-male connection, respectively.", "The downhole tool 202 may be run into wellbore (206, FIG.", "2A) to a desired depth or position by way of the workstring (212, FIG.", "2A) that may be configured with the setting device or mechanism.", "The workstring 212 and setting sleeve 254 may be part of the plugging tool system 200 utilized to run the downhole tool 202 into the wellbore, and activate the tool 202 to move from an unset to set position.", "The set position may include seal element 222 and/or slips 234, 242 engaged with the tubular (208, FIG.", "2B).", "In an embodiment, the setting sleeve 254 (that may be configured as part of the setting mechanism or workstring) may be utilized to force or urge compression of the seal element 222, as well as swelling of the seal element 222 into sealing engagement with the surrounding tubular.", "The setting device(s) and components of the downhole tool 202 may be coupled with, and axially and/or longitudinally movable along mandrel 214.When the setting sequence begins, the mandrel 214 may be pulled into tension while the setting sleeve 254 remains stationary.", "The lower sleeve 260 may be pulled as well because of its attachment to the mandrel 214 by virtue of the coupling of threads 218 and threads 262.As shown in the embodiment of FIGS.", "2C and 2D, the lower sleeve 260 and the mandrel 214 may have matched or aligned holes 281A and 281B, respectively, whereby one or more anchor pins 211 or the like may be disposed or securely positioned therein.", "In embodiments, brass set screws may be used.", "Pins (or screws, etc.)", "211 may prevent shearing or spin-off during drilling or run-in.", "As the lower sleeve 260 is pulled in the direction of Arrow A, the components disposed about mandrel 214 between the lower sleeve 260 and the setting sleeve 254 may begin to compress against one another.", "This force and resultant movement causes compression and expansion of seal element 222.The lower sleeve 260 may also have an angled sleeve end 263 in engagement with the slip 234, and as the lower sleeve 260 is pulled further in the direction of Arrow A, the end 263 compresses against the slip 234.As a result, slip(s) 234 may move along a tapered or angled surface 228 of a composite member 220, and eventually radially outward into engagement with the surrounding tubular (208, FIG.", "2B).", "Serrated outer surfaces or teeth 298 of the slip(s) 234 may be configured such that the surfaces 298 prevent the slip 234 (or tool) from moving (e.g., axially or longitudinally) within the surrounding tubular, whereas otherwise the tool 202 may inadvertently release or move from its position.", "Although slip 234 is illustrated with teeth 298, it is within the scope of the disclosure that slip 234 may be configured with other gripping features, such as buttons or inserts.", "Initially, the seal element 222 may swell into contact with the tubular, followed by further tension in the tool 202 that may result in the seal element 222 and composite member 220 being compressed together, such that surface 289 acts on the interior surface 288.The ability to “flower,” unwind, and/or expand may allow the composite member 220 to extend completely into engagement with the inner surface of the surrounding tubular.", "Additional tension or load may be applied to the tool 202 that results in movement of cone 236, which may be disposed around the mandrel 214 in a manner with at least one surface 237 angled (or sloped, tapered, etc.)", "inwardly of second slip 242.The second slip 242 may reside adjacent or proximate to collar or cone 236.As such, the seal element 222 forces the cone 236 against the slip 242, moving the slip 242 radially outwardly into contact or gripping engagement with the tubular.", "Accordingly, the one or more slips 234, 242 may be urged radially outward and into engagement with the tubular (208, FIG.", "2B).", "In an embodiment, cone 236 may be slidingly engaged and disposed around the mandrel 214.As shown, the first slip 234 may be at or near distal end 246, and the second slip 242 may be disposed around the mandrel 214 at or near the proximate end 248.It is within the scope of the disclosure that the position of the slips 234 and 242 may be interchanged.", "Moreover, slip 234 may be interchanged with a slip comparable to slip 242, and vice versa.", "Because the sleeve 254 is held rigidly in place, the sleeve 254 may engage against a bearing plate 283 that may result in the transfer load through the rest of the tool 202.The setting sleeve 254 may have a sleeve end 255 that abuts against the bearing plate end 284.As tension increases through the tool 202, an end of the cone 236, such as second end 240, compresses against slip 242, which may be held in place by the bearing plate 283.As a result of cone 236 having freedom of movement and its conical surface 237, the cone 236 may move to the underside beneath the slip 242, forcing the slip 242 outward and into engagement with the surrounding tubular (208, FIG.", "2B).", "The second slip 242 may include one or more, gripping elements, such as buttons or inserts 278, which may be configured to provide additional grip with the tubular.", "The inserts 278 may have an edge or corner 279 suitable to provide additional bite into the tubular surface.", "In an embodiment, the inserts 278 may be mild steel, such as 1018 heat treated steel.", "The use of mild steel may result in reduced or eliminated casing damage from slip engagement and reduced drill string and equipment damage from abrasion.", "In an embodiment, slip 242 may be a one-piece slip, whereby the slip 242 has at least partial connectivity across its entire circumference.", "Meaning, while the slip 242 itself may have one or more grooves (or notches, undulations, etc.)", "244 configured therein, the slip 242 itself has no initial circumferential separation point.", "In an embodiment, the grooves 244 may be equidistantly spaced or disposed in the second slip 242.In other embodiments, the grooves 244 may have an alternatingly arranged configuration.", "That is, one groove 244A may be proximate to slip end 241, the next groove 244B may be proximate to an opposite slip end 243, and so forth.", "The tool 202 may be configured with ball-plug, check-valve assembly that includes a ball seat 286.The assembly may be removably or integrally formed therein.", "In an embodiment, the bore 250 of the mandrel 214 may be configured with the ball seat 286 formed or removably disposed therein.", "In some embodiments, the ball seat 286 may be integrally formed within the bore 250 of the mandrel 214.In other embodiments, the ball seat 286 may be separately or optionally installed within the mandrel 214, as may be desired.", "The ball seat 286 may be configured in a manner so that a ball 285 seats or rests therein, whereby the flowpath through the mandrel 214 may be closed off (e.g., flow through the bore 250 is restricted or controlled by the presence of the ball 285).", "For example, fluid flow from one direction may urge and hold the ball 285 against the seat 286, whereas fluid flow from the opposite direction may urge the ball 285 off or away from the seat 286.As such, the ball 285 and the check valve assembly may be used to prevent or otherwise control fluid flow through the tool 202.The ball 285 may be conventionally made of a composite material, phenolic resin, etc., whereby the ball 285 may be capable of holding maximum pressures experienced during downhole operations (e.g., fracing).", "By utilization of retainer pin 287, the ball 285 and ball seat 286 may be configured as a retained ball plug.", "As such, the ball 285 may be adapted to serve as a check valve by sealing pressure from one direction, but allowing fluids to pass in the opposite direction.", "The tool 202 may be configured as a drop-ball plug, such that a drop ball may be flowed to a drop ball seat 259.The drop ball may be much larger diameter than the ball of the ball check.", "In an embodiment, end 248 may be configured with a drop ball seat surface 259 such that the drop ball may come to rest and seat at in the seat proximate end 248.As applicable, the drop ball (not shown here) may be lowered into the wellbore (206, FIG.", "2A) and flowed toward the drop ball seat 259 formed within the tool 202.The ball seat may be formed with a radius 259A (i.e., circumferential rounded edge or surface).", "In other aspects, the tool 202 may be configured as a bridge plug, which once set in the wellbore, may prevent or allow flow in either direction (e.g., upwardly/downwardly, etc.)", "through tool 202.Accordingly, it should be apparent to one of skill in the art that the tool 202 of the present disclosure may be configurable as a frac plug, a drop ball plug, bridge plug, etc.", "simply by utilizing one of a plurality of adapters or other optional components.", "In any configuration, once the tool 202 is properly set, fluid pressure may be increased in the wellbore, such that further downhole operations, such as fracture in a target zone, may commence.", "The tool 202 may include an anti-rotation assembly that includes an anti-rotation device or mechanism 282, which may be a spring, a mechanically spring-energized composite tubular member, and so forth.", "The device 282 may be configured and usable for the prevention of undesired or inadvertent movement or unwinding of the tool 202 components.", "As shown, the device 282 may reside in cavity 294 of the sleeve (or housing) 254.During assembly, the device 282 may be held in place with the use of a lock ring 296.In other aspects, pins may be used to hold the device 282 in place.", "FIG.", "2D shows the lock ring 296 may be disposed around a part 217 of a setting tool coupled with the workstring 212.The lock ring 296 may be securely held in place with screws inserted through the sleeve 254.The lock ring 296 may include a guide hole or groove 295, whereby an end 282A of the device 282 may slidingly engage therewith.", "Protrusions or dogs 295A may be configured such that during assembly, the mandrel 214 and respective tool components may ratchet and rotate in one direction against the device 282; however, the engagement of the protrusions 295A with device end 282B may prevent back-up or loosening in the opposite direction.", "The anti-rotation mechanism may provide additional safety for the tool and operators in the sense that it may help prevent inoperability of tool in situations where the tool is inadvertently used in the wrong application.", "For example, if the tool is used in the wrong temperature application, components of the tool may be prone to melt, whereby the device 282 and lock ring 296 may aid in keeping the rest of the tool together.", "As such, the device 282 may prevent tool components from loosening and/or unscrewing, as well as prevent tool 202 unscrewing or falling off the workstring 212.Drill-through of the tool 202 may be facilitated by the fact that the mandrel 214, the slips 234, 242, the cone(s) 236, the composite member 220, etc.", "may be made of drillable material that is less damaging to a drill bit than those found in conventional plugs.", "The drill bit will continue to move through the tool 202 until the downhole slip 234 and/or 242 are drilled sufficiently that such slip loses its engagement with the well bore.", "When that occurs, the remainder of the tools, which generally would include lower sleeve 260 and any portion of mandrel 214 within the lower sleeve 260 falls into the well.", "If additional tool(s) 202 exist in the well bore beneath the tool 202 that is being drilled through, then the falling away portion will rest atop the tool 202 located further in the well bore and will be drilled through in connection with the drill through operations related to the tool 202 located further in the well bore.", "Accordingly, the tool 202 may be sufficiently removed, which may result in opening the tubular 208.Accordingly, components of tool 202 may be made of non-dissolvable materials (e.g., materials suitable for and are known to withstand downhole environments [including extreme pressure, temperature, fluid properties, etc.]", "for an extended period of time (predetermined or otherwise) as may be desired).", "Just the same, one or more components of a tool of embodiments disclosed herein may be made of dissolvable materials (e.g., materials suitable for and are known to dissolve in downhole environments [including extreme pressure, temperature, fluid properties, etc.]", "after a brief or limited period of time (predetermined or otherwise) as may be desired).", "In an embodiment, a component made of a dissolvable material may begin to dissolve within about 3 to about 48 hours after setting of the downhole tool 202.In other embodiments, components may be made of a material that may have brittle characteristics under certain conditions.", "In yet other embodiments, components may be made of a material that may have disassociatable characteristics under certain conditions.", "One of skill in the art would appreciate that the material may be the same material and have the same composition, but that the physical characteristic of the material may change, and thus depend on variables such as curing procedures or downhole conditions.", "The material (including a cured byproduct thereof) may be or include a resin.", "The resin may be an anhydride-cured epoxy material.", "It may be possible to use sodium polyacrylate fiber in conjunction therewith, although any fiber that has dissolvable properties associated with it Some resins may be too brittle (or have too low Tg) for certain downhole conditions.", "Accordingly, resins described herein may include a flexibilizer distributed therewith.", "A flexibilizer may include clay(s), hygroscopic clay, nanoclay, bentonite, or any other material that is easily distributable within the resin and reduces brittleness of the resin.", "Carbon nano-tubes may also add strength but promote capillary water flow through the resin matrix.", "Of note, smectic clay minerals, including montmorillonite and bentonite, are known to have dramatic shrink-swell capacity.", "Bentonite is known to have super high affinity for water, which may provide a synergistic effect.", "That is, bentonite may reduce the brittleness of the tool component, but at the same time induce an additional fracture stress to the tool component so that it dissolves more readily (as upon exposure to water, the volume of the bentonite within the tool component may expand up to about approximately 8× from its original state).", "Embodiments herein provide for one or more components of a downhole tool (or other downhole devices) to be made of a material of construction that may include a composition of matter (including a cured byproduct thereof) designed or otherwise having the inherent characteristic to change integrity or other physical attribute when exposed to certain wellbore conditions, such as a change in time, temperature, water, heat, pressure, solution, combinations thereof, etc.", "Heat may be present due to the temperature increase attributed to the natural temperature gradient of the earth, and water may already be present in the existing wellbore fluids.", "The change in integrity may occur in a predetermined time period, which may vary from several minutes to several weeks.", "In some embodiments, the material may degrade to the point of ‘mush,’ while in other embodiments, the material may dissolve or otherwise disintegrate and be carried away by fluid flowing in the wellbore.", "The material may disassociate in some embodiments.", "The temperature of the downhole fluid may affect the rate change in integrity.", "The material need not form a solution when it dissolves in the aqueous phase.", "For example, the material may dissolve, break, or otherwise disassociate into sufficiently small particles (i.e., a colloid), that may be removed by the fluid as it circulates in the well.", "In embodiments, the material may become degradable, but not dissolvable.", "In other embodiments, the material may become degradable, and subsequently dissolvable.", "In still other embodiments, the material may become breakable (or brittle), but not dissolvable.", "In yet other embodiments, the material may become breakable, and subsequently dissolvable.", "In accordance with the disclosure, any unlimited number of devices, apparatuses, tools, etc.", "may utilize one or more components made of a material having a composition of matter according to embodiments herein.", "One such device may be a “frac ball” or “drop ball”.", "As such, for some embodiments there may be a frac ball constructed of a material described herein.", "A downhole tool may also be configured with a “ball in place” (caged ball, etc.)", "that is similarly construct of a material described herein.", "In an operation utilizing one or more components made of a material of embodiments of the disclosure, the material may be differentiated in a manner that leads to different rates in physical change.", "The frac ball of the present disclosure may be constructed of a suitable water-soluble material so that after a predetermined amount of time (presumably after the fracing is done), the frac ball may degrade or otherwise undergo physical change to provide an unobstructed flow path through a tool whereby production fluid may flow to surface.", "Conventionally, downhole dissolvables fall into two groups: 1) a dissolving thermoplastic with a characteristic of hotter temperature, faster dissolve rate; and 2) dissolving metals, typically alloy-based often with other trace metals with a characteristic of being very expensive and cost prohibitive.", "The examples to follow illustrate innovation around the prior art and conventional groups of dissolvables.", "For example, embodiments herein provide for use of constituents that in their own form do not dissolve, e.g., a clay material will ‘swell’ and/or somewhat solidify.", "Other constituents add differing performance characteristics.", "A soluble fiber(s), for example, may provide a ‘pathway’ (s) (in various, including random, direction) for fluid to flow therethrough and more readily attack other constituents.", "Thus, it has been discovered that a dissolving fiber is beneficial (over dissolving powder) because in forming the component or device, ‘pathways’ are formed.", "The pathways remain once the fiber dissolves, and allows fluid to much more readily move into surrounding contact with the other constituents.", "It has been further discovered that upon curing of the initial constituents, the material may be characterized as being dissolvable, disassociatable, degradable, and/or breakable, depending upon the composition, curing process, and/or depending upon the surrounding activation conditions Percentages of constituents and length of fibers can be optimized to yield a desired physical characteristic known to occur in certain conditions.", "Care is needed to avoid temperature conditions that avoid ‘swelling’ the clay and closing of the pathways.", "Accordingly, embodiments herein provide for a material that may include four primary constituents: 1) a matrix or adhesive; 2) a plasticizer or thickener; 3) strengthener; and 4) a soluble medium.", "The matrix (or the adhesive) may be the resin or resin system.", "Among other things the matrix acts to combine and hold other constituents thereto.", "The resin may be an epoxy based resin system.", "In aspects, the resin system may be an epoxy resin with an anhydride hardener.", "The matrix may be an anhydride epoxy, or an epoxy resin hardened with an anhydride, like that of U.S. Pat.", "No.", "5,629,379, incorporated herein by reference in its entirety for all purposes.", "The plasticizer (or thickener) is suitable to ‘thicken’ the resin.", "The resin may be that which has a low viscosity, whereby other constituents may not be able to properly distribute uniformly therein.", "The plasticizer helps in uniform distribution of constituents.", "The plasticizer may be clay-based, including montmorillonite or modified montmorillonite (such as CLAYTONE APA.", "The strengthener may be suitable to increase mechanical properties of the material.", "In aspects, it may be desirable to want high compressive strength.", "An example strengthener includes glass bubbles.", "The glass does not increase tensile strength, but may increase plasticity—thus dramatically increasing compressive strength of, for example, a frac ball.", "Normally, a frac ball is brittle, as the compressive strength is not very high.", "Glass (e.g., glass microspheres) may be added.", "If not added, the resulting material may not have high compressive strength.", "The soluble medium is suitable to provide pathways within the cured material.", "Once the material is subjected to its activation environment, the medium dissolves, and the surrounding fluid can easily and readily infiltrate and reach other constituents via the pathways.", "The resultant cured material has a synergistic benefit of having a specific gravity of close to one, which of significance is substantially equivalent to most wellbore fluids (which are often predominantly water).", "Accordingly, the material may be naturally buoyant in the presence of frac fluid, whereby the material may be readily flowed back.", "This may be the case whether the material is in its original state, such as a solid frac ball, or the material has undergone a physical/chemical change (e.g., solid to dissolved).", "In some aspects, it may be preferable or desired to flow back a ball.", "In other aspects, it is undesirable to flow a ball back, and instead preferred to keep materials downhole.", "Embodiments herein provide for the ability to form a composition useable as a material for a device that can be customized for a specific customer need (e.g., material that is readily flowed back; or material that is not readily flowed back).", "Embodiments of the disclosure pertain to a composition of matter prior to curing that may include in the range of: about 100 parts by weight of an epoxy resin with an anhydride curing agent; about 10-20 parts by weight of a clay; about 20-30 parts by weight of a fiber; and about 5-10 parts by weight of a glass.", "Embodiments of the disclosure pertain to a composition of matter prior to curing that may be: a.", "100 parts by weight of an epoxy resin with an anhydride curing agent; b. about 10-20 parts by weight of a clay; c. about 20-30 parts by weight of a fiber; and d. about 5-10 parts by weight of a glass.", "One of skill in the art would appreciate subjecting a material having a composition of matter in accordance with embodiments of the disclosure to a curing process.", "The physical properties of the resultant cured material may dependent in a manner of significance to the selected constituents and/or curing process.", "The curing process may include two aspects, first pertaining to a curing device, such as an oven, and secondly pertaining to what happens to the material in the oven, with the latter being dependent on the form.", "Because of the insulating properties of the material, there may be ‘soak’ (i.e., a held temperature) for a period of time to ensure the core reaches desired temp.", "The constituents may be mixed together in a powered mixer of suitable HP and volume.", "The mixed material may then be transferred into a mold suitable for the curing process.", "The mold may be the shape of the desired cured-material device.", "For example, the mold may be spherical in shape to produce a spherical ball.", "Just the same, the mold may produce a resultant product that may then be subjected to a finishing process such as grinding or machining in order to produce the desired cured-material device.", "The curing process may include operating a curing device to start within an initial curing temperature in the range of about 70° F. to about 100° F. The material may then be placed therein, and the device closed in a manner to maintain heat.", "The curing device may then be heated a ramp up rate of about 0.2-2° F./min to a temperature in the range of about 120° F. to about 200° F. The device may be held at a temperature of 120° F. to about 200° F. for a predetermined amount of soak time of about 30 minutes to about 120 minutes.", "The curing device may then be heated a ramp up rate of about 0.2-2° F./min to a temperature in the range of about 160° F. to about 250° F. The curing device may then be heated a ramp up rate of about 1-4° F./min to a temperature in the range of about 250° F. to about 350° F. The device may be held at a temperature of 250° F. to about 350° F. for a predetermined amount of soak time of about 30 minutes to about 120 minutes.", "The curing device may then be ramped down at a rate of about 0.2-2° F./min to a temperature in the range of about 70° F. to about 100° F. The forgoing curing process operation may yield a material that experiences a starting material temperature in the range of about 70° F. to about 100° F. The material experiences a temperature ramp up 12-120° F./hr to a temperature in the range of about 300° F. to about 400° F. The material may have a higher material temperature than the curing device as a result of a thermal reaction from the activity of the selected constituents.", "The device may be operated to hold the material at a material temperature of about 300° F. to about 400° F. for a predetermined amount of time in the range of about 30 minutes to about 120 minutes.", "The material may then have its temperature ramped down at a rate of 12-120° F./hr to a temperature in the range of about 70° F. to about 100° F. MATERIAL OF CONSTRUCTION—COMPOSITION—EXAMPLE 1 The composition prior to curing of Example 1 may include a base epoxy system that comprises an epoxy resin with an anhydride curing agent (100 parts by wt.).", "The base resin system may be desirably prone to break down in high temp/high pressure water.", "The composition may include about 10 to about 20 parts modified montmorillonite clay.", "The composition may include about 5-10 parts by weight high-strength (8 ksi collapse), glass spheres.", "The spheres may be hollow.", "The spheres may have a diameter of about 1 to about 1000 microns.", "The spheres may have an average diameter of about 15 to about 25 microns.", "The composition may include a water-soluble fiber, such as sodium polyacrylate.", "The material of the present disclosure may include a composition of matter that includes one or more of an epoxy resin with an anhydride curing agent; a clay; a water-soluble fiber; and a glass.", "Accordingly, embodiments of the disclosure pertain to the composition having a clay comprises modified montmorillonite, and glass that includes high-strength, hollow-glass microspheres.", "In aspects, the clay may include or be modified montmorillonite; and/or the glass may include or be high-strength hollow glass microspheres.", "The composition may include a water-soluble material.", "In aspects, the water-soluble material may include or be sodium polyacrylate.", "The resin system may be an anhydride-cured epoxy material.", "The composition is subjected to curing in order to yield a finalized (i.e., cured) product.", "A device of the disclosure may be formed during the curing process, or subsequently thereafter.", "The composition may be cured with a curing process of the present disclosure.", "COMPOSITION—EXAMPLE 2 The composition prior to curing of Example 2 may include a base resin system that comprises an epoxy with an anhydride-based curing agent (˜100 parts by wt.).", "The base resin system may be desirably prone to break down in high temp/high pressure water.", "The composition may include about 0 to about 30 parts of a clay-based material.", "The composition may include about 25 to about 30 parts by weight desiccated bentonite (swelling clay).", "The composition may include about 5 to about 10 parts Montmorillonite (non-swelling/water-conducting) clay.", "The composition may include about 0 to about 10 parts by weight of a glass material.", "In aspects, the glass material may be glass microspheres, typically being between 1 and 1000 micrometers in diameter.", "In aspects, the glass material may be a low-pressure (˜800 psi collapse) hollow glass nanospheres.", "The composition may include an organic fiber (such as hemp or comparable) or glass fiber.", "The composition may include a small or trace amount (by weight) of a water-soluble material, such as salt or sugar (or both).", "The presence of the water-soluble material may contribute to the material being ‘mushy’ (in contrast to brittle) under certain conditions.", "The material of the present disclosure may include a composition of matter that includes one or more of an epoxy with an anhydride-based hardener; a swelling clay; a non-swelling clay; and a glass.", "Accordingly, embodiments of the disclosure pertain to the composition that may have swelling clay that includes bentonite, non-swelling clay that includes montmorillonite, and glass that includes glass spheres.", "In aspects, the swelling clay may include or be bentonite; the non-swelling clay may include or be montmorillonite; and/or the glass may include or be low pressure hollow glass nanospheres.", "The composition may include at least one of organic hemp fiber, glass fiber, and combinations thereof.", "The composition may include a water-soluble material.", "In aspects, the water-soluble material may include or be one of a salt, a sugar, and combinations thereof.", "The resin system may be made from or include polyglycolic acid (PGA).", "The resin system may be an anhydride-cured epoxy material.", "The resin system may be cast or molded pure resin or may be reinforced with short chopped glass, carbon or natural fiber hemp, canvas or silk.", "It may be possible to use PGA fiber in conjunction therewith, although any resin that may have dissolvable properties associated therewith may be used.", "Some resins may be too brittle (or have too low Tg) for certain downhole conditions.", "Accordingly, resins described herein may include a flexibilizer distributed therewith.", "A flexibilizer may include clay(s), hygroscopic clay, nanoclay, bentonite, or any other material that is easily distributable within the resin and reduces brittleness of the resin.", "Carbon nano-tubes may also add strength but promote capillary water flow through the resin matrix.", "The composition is subjected to curing in order to yield a finalized product.", "A device of the disclosure may be formed during the curing process, or subsequently thereafter.", "The composition may be cured with a curing process of the present disclosure.", "EXAMPLE 3 The composition of Example 3 prior to curing may include about 100 parts by weight base resin system that comprises an epoxy with a curing agent (or ‘hardener’).", "The base resin may be desirably prone to break down in a high temp and/or high pressure aqueous environment.", "The epoxy may be a cycloaliphatic epoxy resin with a low viscosity and a high glass transition temperature.", "The epoxy may be characterized by having high adhesability with fibers.", "As an example, the epoxy may be 3,4-epoxycyclohexylmethyl-3′,4′-epoxycyclohexane-carboxylate.", "The hardener may be an anhydride, i.e., anhydride-based.", "For example, the curing agent may be a methyl carboxylic, such as methyl-5-norborene-2, 3-dicarboxylic anhydride.", "The hardener may include, and be pre-catalyzed with, an accelerator.", "The accelerator may be imidazole-based.", "The accelerator may help in saving or reducing the curing time.", "The ratio of epoxy to curing agent may be in the range of about 0.5 to about 1.5.In more particular aspects, the ratio may be about 0.9 to about 1.0.Processing conditions of the base resin system may include multiple stages of curing.", "The composition may include an additive comprising a clay.", "The additive may be a solid in granular or powder form.", "The additive may be about 0 to about 30 parts by weight of the composition of a montmorillonite-based clay.", "In aspects, the clay may be about 0 to about 20 parts by weight of the composition.", "The additive may be an organophilic clay.", "An example of a suitable clay additive may be CLAYTONE® APA by BYK Additives, Inc.", "The composition may include a glass, such as glass bubbles or spheres (including microspheres and/or nanospheres).", "The glass may be about 0 to about 20 parts by weight of the composition.", "In aspects, the glass may be about 5 to about 15 parts by weight of the composition.", "An example of a suitable glass may be 3M Glass Bubbles 342XHS by 3M.", "The composition may include a fiber.", "The fiber may be organic.", "The fiber may be a water-soluble fiber.", "The fiber may be in the range of about 0 to about 30 parts by weight of the composition.", "In aspects, the fiber may be in the range of about 15 to about 25 parts by weight.", "The fiber may be made of a sodium polyacrylate-based material.", "The fiber may resemble a thread or string shape.", "In aspects, the fiber may have a fiber length in the range of about 0.1 mm to about 2 mm.", "The fiber length may be in the range of about 0.5 mm to about 1 mm.", "The fiber length may be in the range of substantially 0 mm to about 6 mm.", "The fiber may be a soluble fiber like EVANESCE™ water soluble fiber from Technical Absorbents Ltd.", "The composition is subjected to curing in order to yield a finalized product.", "A device of the disclosure may be formed during the curing process, or subsequently thereafter.", "The composition may be cured with a curing process of the present disclosure.", "EXAMPLE 4 The composition of Example 4 may be characterized as a material that includes a polyester and aluminosilicate clay.", "The composition may include an ester-based component, a base resin, and an additive characterized by the ability to become acidic in an aqueous environment.", "The additive may be Halloysite like that provided by Applied Materials, which may be in the form of a nano-tube.", "The nano-tube may be made by rolling a sheet of aluminosilicate clay.", "The additive may become acidic in aqueous environments and suitable to attack plastic, especially thermoplastics having ester groups, like polyethylene terephthalate (PET).", "The additive may increase the strength of the material.", "The additive may be suitable for aggressively attacking polyester in aqueous environments.", "Halloysite may be characterized as an aluminosilicate mineral with the same chemistry as kaolinite but instead of the flatsheets typical of kaolinite, the sheets having been rolled up into tubes by a natural hydrothermal process.", "The composition may include a modified Halloysite/PLLA (poly (L-lactic acid)/glass fiber.", "The composition is subjected to curing in order to yield a finalized product.", "A device of the disclosure may be formed during the curing process, or subsequently thereafter.", "The composition may be cured with a curing process of the present disclosure.", "Referring now to FIGS.", "3A and 3B together, a longitudinal cross-sectional view of a downhole tool with a hybrid sleeve, in accordance with embodiments disclosed herein, are shown.", "Downhole tool 2102 may be run, set, and operated as described herein and in other embodiments (such as in System 200), and as otherwise understood to one of skill in the art.", "Components of the downhole tool 2102 may be arranged and disposed about a mandrel or mandrel sleeve 2114, as described herein and in other embodiments, and as otherwise understood to one of skill in the art.", "Thus, downhole tool 2102 may be comparable or identical in aspects, function, operation, components, etc.", "as that of other tool embodiments, and redundant discussion is limited for sake of brevity.", "On occasion, it may be necessary or otherwise desired to produce a fluid from the formation while leaving a set plug in place.", "However, an inner diameter (ID) of a bore (e.g., 250, FIG.", "2D) in a mandrel (214) may be too narrow to effectively and efficiently produce the fluid—thus in embodiments it may be desirous to have an oversized ID 2131 through the tool 2102.The ID of the bore is normally adequate to allow drop balls to pass therethrough, but may be inadequate for production.", "In order to produce desired fluid flow, it often becomes necessary to drill out a set tool—this requires a stop in operations, rig time, drill time, and related operator and equipment costs.", "On the other hand, the presence of the oversized ID 2131 of bore 2151, and thus a larger cross-sectional area as compared to bore 2150, provides effective and efficient production capability through the tool 2102 without the need to resort to drilling of the tool.", "However, a reduced wall thickness 2127 of mandrel sleeve 2114 may be problematic to the characteristics of the tool 2102, especially during the setting sequence.", "Accordingly, a sleeve insert (or liner, reinforcing member, etc.)", "2153 may be used to provide an effective wall thickness of the mandrel 2114 during the run-in and setting sequence comparable to other embodiments disclosed herein.", "Referring briefly to FIGS.", "3C and 3D together, an isometric component breakout view of a downhole tool with a hybrid sleeve according to embodiments of the disclosure, and an isometric component breakout view of a system using a downhole tool with a hybrid sleeve, respectively, in accordance with embodiments disclosed herein, are shown.", "FIG.", "3D depicts a wellbore 2106 formed in a subterranean formation (210) with a tubular 2108 disposed therein.", "A workstring 2112 (which may include a part 2117 of a setting tool coupled with adapter 2152) may be used to position or run the downhole tool 2102 into and through the wellbore 2106 to a desired location.", "In accordance with embodiments of the disclosure, the tool 2102 may be configured as a plugging tool, which may be set within the tubular 2108 in such a manner that the tool 2102 forms a fluid-tight seal against the inner surface 2107 of the tubular 2108.In an embodiment, the downhole tool 2102 may be configured as a frac plug, where flow into one section of the wellbore 2106 may be blocked and otherwise diverted into the surrounding formation or reservoir.", "Once the tool 2102 reaches the set position within the tubular, the setting mechanism or workstring 2112 may be detached from the tool 2102 by various methods, resulting in the tool 2102 left in the surrounding tubular and one or more sections of the wellbore isolated.", "In an embodiment, once the tool 2102 is set, tension may be applied to the adapter 2152 until the threaded connection between the adapter 2152 and the mandrel 2114 (or insert 2153) is broken.", "For example, the mating threads on the adapter 2152 and the insert 2153 (2156 and 2116, FIG.", "22A) may be designed to shear, and thus may be pulled and sheared accordingly in a manner known in the art.", "In an embodiment, the downhole tool 2102 and/or its components may be a drillable tool made from drillable composite material(s), such as glass fiber/epoxy, carbon fiber/epoxy, glass fiber/PEEK, carbon fiber/PEEK, etc.", "Other resins may include phenolic, polyamide, etc.", "One or more mating surfaces of the downhole tool 2102 may be configured with an angle, such that corresponding components may be placed under compression instead of shear.", "In accordance with the disclosure, components of tool 2102 may be made of non-dissolvable materials (e.g., materials suitable for and are known to withstand downhole environments [including extreme pressure, temperature, fluid properties, etc.]", "for an extended period of time (predetermined or otherwise) as may be desired).", "In accordance with the disclosure, components of tool 2102 may be made of dissolvable materials (e.g., materials suitable for and are known to dissolve in downhole environments [including extreme pressure, temperature, fluid properties, etc.]", "after a brief or limited period of time (predetermined or otherwise) as may be desired).", "In an embodiment, a component made of a dissolvable material may begin to dissolve within about 3 to about 48 hours after setting of the downhole tool.", "In aspects, the insert 2153 may be made of a composition of material described herein.", "The insert 2153 may be made of a material that is adequate to provide durability and strength to the tool 2102 for a sufficient amount of time that includes run-in, setting and frac, but then begins to change (i.e., degrade, dissolve, etc.).", "shortly thereafter.", "The outer sleeve 2114 may be machined from metal, including such as aluminum or dissolvable aluminum alloy.", "Alternatively, the sleeve 2114 may be formed from a material (or its cured byproduct) having a clay, glass bubble, water-soluble fiber material further mixed with a dissolving resin.", "The downhole tool 2102 may include the mandrel sleeve 2114 that extends through the tool (or tool body) 2102.The mandrel sleeve 2114 may include a flowpath or bore 2151 formed therein (e.g., an axial bore).", "The bore 2151 may extend partially or for a short distance through the mandrel 2114, or the bore 2151 may extend through the entire mandrel sleeve 2114, with an opening at its proximate end 2148 and oppositely at its distal end 2146.The presence of the bore or other flowpath through the mandrel sleeve 2114 may indirectly be dictated by operating conditions.", "That is, in most instances the tool 2102 may be large enough in diameter (e.g., in a range of about 4-5 inches) that the bore 2151 may be correspondingly large enough (e.g., 3 inches) so that fluid may be produced therethrough.", "The tool OD should probably not exceed 5.5 inches for standard operation.", "The small ID should be around 1″.", "The dissolved ID is preferably 3″.", "With the presence of the bore 2151, the mandrel sleeve 2114 may have an inner bore surface (2147, FIG.", "22B), which may include one or more threaded surfaces formed thereon.", "As such, there may be a first set of threads 2117 configured for coupling the mandrel sleeve 2114 with corresponding threads 2155 of the sleeve insert 2153.The setting device(s) and components of the downhole tool 2102 may be as described and disclosed with other embodiments herein.", "The tool 2102 may include a lower sleeve 2160 engaged with the mandrel sleeve 2114.The mandrel sleeve 2114 and the lower sleeve 2160 may be threadingly engaged via mated threaded connection 2118.Accordingly, during setting, as the lower sleeve 2160 is pulled, the components disposed about the mandrel sleeve 2114 between the lower sleeve 2160 and the setting sleeve 2154 may begin to compress against one another.", "This force and resultant movement causes compression and expansion of seal element 2122.Slip(s) 234 may move or otherwise be urged eventually radially outward into engagement with the surrounding tubular 2108.Serrated outer surfaces or teeth 2198 of the slip(s) 2134 may be configured such that the surfaces 298 prevent the slip 2134 (or tool) from moving (e.g., axially or longitudinally) within the surrounding tubular, whereas otherwise the tool 2102 may inadvertently release or move from its position.", "Although slip 2134 is illustrated with teeth 2198, it is within the scope of the disclosure that slip 2134 may be configured with other gripping features, such as buttons or inserts.", "Because the sleeve 2154 is held rigidly in place, the sleeve 2154 may engage against a bearing plate 2183 that may result in the transfer load through the rest of the tool 2102.The setting sleeve 2154 may have a sleeve end 2155 that abuts against the bearing plate end 284.The second slip 2134a may include one or more, gripping elements, which may be configured to provide additional grip with the tubular 2108.A ball seat 2186 may be configured in a manner so that a ball 2185 seats or rests therein, whereby the flowpath through the mandrel sleeve 2114 (or sleeve insert 2153) may be closed off (e.g., flow through the bore 2150 is restricted or controlled by the presence of the ball 2185).", "For example, fluid flow from one direction may urge and hold the ball 2185 against the seat 2186.Ball 2185 may be made of a material of composition of embodiments disclosed herein.", "It should be apparent to one of skill in the art that the tool 2102 of the present disclosure may be configurable as a frac plug, a drop ball plug, bridge plug, etc.", "simply by utilizing one of a plurality of adapters or other optional components.", "In any configuration, once the tool 2102 is properly set, fluid pressure may be increased in the wellbore, such that further downhole operations, such as fracture in a target zone, may commence.", "The tool 2102 may include an anti-rotation assembly that includes an anti-rotation device or mechanism 2182, which may be a spring, a mechanically spring-energized composite tubular member, and so forth.", "The device 2182 may be configured and usable for the prevention of undesired or inadvertent movement or unwinding of the tool 2102 components.", "As shown, the device 2182 may reside in cavity 2194 of the sleeve (or housing) 2154.During assembly, the device 2182 may be held in place with the use of a lock ring 2196.In other aspects, pins may be used to hold the device 2182 in place.", "The anti-rotation mechanism may provide additional safety for the tool and operators in the sense it may help prevent inoperability of tool in situations where the tool is inadvertently used in the wrong application.", "As such, the device 2182 may prevent tool components from loosening and/or unscrewing, as well as prevent tool 2102 unscrewing or falling off the workstring 2112.Drill-through of the tool 2102 may be facilitated by the fact that the mandrel sleeve 2114 and other components, etc.", "may be made of drillable material that is less damaging to a drill bit than those found in conventional plugs.", "The drill bit will continue to move through the tool 2102 until the slips are drilled sufficiently that such slip loses its engagement with the well bore.", "Remaining components may fall into the well or onto another tool positioned therebelow.", "Accordingly, the tool 2102 may be sufficiently removed, which may result in opening the tubular 208.Components, such as the slip 2134 may be prefilled or prefitted with a reactant that aids in destruction of the slip and other tool components once the reactant is exposed to the downhole environment.", "The reactant may be, for example, anionic, salt-based, caustic, sulfur, sodium polyacrylate, or other suitable material that becomes highly reactive upon wetness or exposure to an aqueous fluid.", "Advantages The composition(s) of matter disclosed or claimed herein are not limited in utility to downhole conditions or operations (and related tools, devices, etc.", "), but instead may find utility in many applications in which initial hardness (strength) or durability, and subsequent degradability, dissolvability, breakage, dissociation, etc., is desired.", "Yet other advantages may be recognized during post-frac, where downhole fluids can flow without intervention of a drilling rig to remove the tool.", "In certain embodiments, the component or device degrades or undergoes other physical change, reducing hydraulic restriction and allows valuable fluids to be recovered and/or flow back frac water and potentially start oil/gas production.", "Faster is better.", "Advantageously this can be done with just a hose and tank truck.", "While example embodiments of the disclosure have been shown and described, modifications thereof can be made by one skilled in the art without departing from the spirit and teachings of the disclosure.", "These embodiments are exemplary only and not limiting.", "Many variations and modifications of the disclosure disclosed herein are possible and are within the scope of the disclosure.", "Where numerical ranges or limitations are expressly stated, such express ranges or limitations should be understood to include iterative ranges or limitations of like magnitude falling within the expressly stated ranges or limitations.", "The use of the term “optionally” with respect to any element of a claim is intended to mean that the subject element is required, or alternatively, is not required.", "Both alternatives are intended to be within the scope of the claim.", "Use of broader terms such as comprises, includes, having, etc.", "should be understood to provide support for narrower terms such as consisting of, consisting essentially of, comprised substantially of, and the like.", "Accordingly, the scope of protection is not limited by the description set out above but is only limited by the claims which follow, that scope including all equivalents of the subject matter of the claims.", "Each and every claim is incorporated into the specification as an embodiment of the present disclosure.", "Thus, the claims are a further description and are an addition to the preferred embodiments of the present disclosure.", "The inclusion or discussion of a reference is not an admission that it is prior art to the present disclosure, especially any reference that may have a publication date after the priority date of this application.", "The disclosures of all patents, patent applications, and publications cited herein are hereby incorporated by reference, to the extent they provide background knowledge; or exemplary, procedural or other details supplementary to those set forth herein." ] ]
Patent_15876120
[ [ "Peer to peer geolocation system", "A method and apparatus for location sharing, consisting of sending a location report by a location determining device to a plurality of network enabled devices over a peer-to-peer network, the location determining device being associated with a first digital key pair.", "A first of the plurality of network enabled devices, associated with a second digital key pair, performs a validation computation on the location report and submits a validation computation result and the location report to a remainder of the plurality of network enabled devices for inclusion in a shared ledger.", "Including the location report creates commercially-valued credits associated with the public key of the second digital key pair recorded in the shared ledger.", "A transfer of commercially-valued credits from association with the first public key of the first digital key pair to the public key of the second digital key pair is also recorded in the shared ledger." ], [ "1.A method for sharing location information comprising: determining, by a network connected location determining device, a location status of the network connected location determining device, said location status comprising two or more of: location coordinates of the network connected location determining device, an accuracy of the location coordinates of the network connected location determining device, an altitude of the network connected location determining device, an accuracy of the altitude of the network connected location determining device, a heading of the network connected location determining device, an accuracy of the heading of the network connected location determining device, a velocity of the network connected location determining device, an accuracy of the velocity of the network connected location determining device, an acceleration of the network connected location determining device, an accuracy of the acceleration of network connected location determining device; and generating, by the network connected location determining device, a location report comprising the location status; and transmitting, by the network connected location determining device, the location report to a distributed ledger maintained by a plurality of network connected devices, for inclusion in the distributed ledger.", "2.The method of claim 1, wherein the location coordinates of the network connected location determining device are determined by the network connected location determining device using one or more of: a global navigation satellite system receiver, an altimeter, a magnetometer, a gyroscopic sensor, an accelerometer, a wireless local area network module, a wireless wide area network module, a Bluetooth module.", "3.The method of claim 1, wherein the heading of the network connected location determining device is determined by the network connected location determining device using one or more of: a global navigation satellite system receiver, a magnetometer, a gyroscopic sensor, an accelerometer, a wireless local area network module, a wireless wide area network module, a Bluetooth module.", "4.The method of claim 1, wherein an accuracy of a one or more of: the location coordinates of the network connected location determining device, the altitude of the network connected location determining device, the heading of the network connected location determining device, the velocity of the network connected location determining device, the acceleration of the network connected location determining device, are determined by the network connected location determining device through the use of a one or more of a plurality of wireless components comprising one or more of: a global navigation satellite system receiver, a wireless local area network module, a wireless wide area network module, a Bluetooth module by determining a one or more of: a time difference of arrival of data frames, a signal strength determination, a signal trilateration, an other wireless position accuracy determination technique.", "5.The method of claim 1, further comprising: generating a plurality of location reports, by the network connected location determining device; and transmitting, by the network connected location determining device, the plurality of location reports to the distributed ledger maintained by the plurality of network connected devices, for inclusion in the distributed ledger.", "6.The method of claim 5, further comprising: encrypting an at least part of an at least one of the plurality of location reports by the network connected location determining device using a cryptographic key.", "7.The method of claim 5, wherein the plurality of location reports, in combination, comprise the location status of the network connected location determining device.", "8.A client device comprising: a location determining component; a network connectivity component; a plurality of wireless components comprising one or more of: a global navigation satellite system receiver, a wireless local area network module, a wireless wide area network module, a Bluetooth module; one or more processors; and storage media comprising computer instructions, wherein when computer instructions are executed on the one or more processors of the network connected location determining device, operations are caused comprising: determining, by the client device, a location status of the client device, said location status comprising two or more of: location coordinates of the client device, an accuracy of the location coordinates of the client device, an altitude of the client device, an accuracy of the altitude of the client device, a heading of the client device, an accuracy of the heading of the client device, a velocity of the client device, an accuracy of the velocity of the client device, an acceleration of the client device, an accuracy of the acceleration of the client device; and generating, by the client device, a location report comprising the location status; and transmitting, by the client device, the location report to a distributed ledger maintained by a plurality of network connected devices, for inclusion in the distributed ledger.", "9.The client device of claim 8, wherein the location coordinates of the client device are determined by the client device using one or more of: a global navigation satellite system receiver, an altimeter, a magnetometer, a gyroscopic sensor, an accelerometer, a wireless local area network module, a wireless wide area network module, a Bluetooth module.", "10.The client device of claim 8, wherein the heading of the client device is determined by the client device using one or more of: a global navigation satellite system receiver, a magnetometer, a gyroscopic sensor, an accelerometer, a wireless local area network module, a wireless wide area network module, a Bluetooth module.", "11.The client device of claim 8, wherein the accuracy of a one or more of: the location coordinates of the client device, the altitude of the client device, the heading of the client device, the velocity of the client device, the acceleration of the client device, are determined by the client device through the use of a one or more of the plurality of wireless components to determine: a time difference of arrival of data frames, a signal strength determination, a signal trilateration, an other wireless position accuracy determination technique.", "12.The client device of claim 8, further comprising: generating a plurality of location reports, by the client device; and transmitting, by the client device, the plurality of location reports to the distributed ledger maintained by the plurality of network connected devices, for inclusion in the distributed ledger.", "13.The client device of claim 12, further comprising: encrypting an at least part of an at least one of the plurality of location reports by the client device using a cryptographic key.", "14.The client device of claim 12, wherein the plurality of location reports, in combination, comprise the location status of the client device." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>An entity such as a parent of a child, a haulage company or delivery service, a prison system, or a car rental company, may need to track a location of users or assets, for example but not limited to: ensuring safety, for legal reasons, or in order to secure such assets.", "A common method for reporting and storing location data is in a database connected to a network such as are known from US2014074667.If a location data is recorded in a database maintained by the entity, there are high costs associated with installing and maintaining the hardware and network infrastructure.", "If the location is recorded in a facility maintained by a third party such as a data storage provider, then there is a risk that due to network failure or other technical issues the data storage facility will at some times not be available to be queried by the entity, or to be written to by a location aware device to be tracked by the entity.", "In extreme cases the location data may be irretrievably lost.", "Furthermore, if the database is maintained by the third party, there is a risk that the location data may be revealed to other parties, hacked, corrupted, or otherwise altered, without the knowledge of the entity or possibly the third party.", "It is the intention of the present invention to address the shortcomings of the prior art, i.e.", "the problems of establishing and maintaining a network enabled data storage system, ensuring the integrity of the stored data, and providing always-available data access for users of the system.", "Furthermore, if the method used is based on a distributed system, no individual maintenance costs arise, there is no single point of failure, and through an inherent cryptographic structure integrity is maintained." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>In accordance with the present invention, a solution is provided for reporting, storing and subsequently retrieving the locations of devices or objects in a distributed and secure manner.", "The problems are establishing and maintaining a network enabled data storage system, ensuring the integrity of the stored data, and providing always-available data access for users of the system.", "If the method used is based on a distributed system, no individual maintenance costs arise, there is no single point of failure, and through an inherent cryptographic structure integrity is maintained.", "Embodiments of the invention are based on the reporting of location in a location report by a network enabled location determining device communicating through a peer-to-peer network system to a plurality of network enabled devices.", "A first of the plurality of network enabled devices performs a validation computation on the location report and forwards a result of the validation computation to the plurality of network enabled devices for inclusion in a shared ledger of location reports.", "The network enabled location determining device may include a location module that may comprise a global navigation satellite system receiver (GNSS receiver), a magnetometer, an accelerometer, an altimeter, and a gyroscopic sensor for determining the location of the device.", "Further methods and apparatus for determining the location of the device may include trilateration or time difference of arrival calculations using a wireless local area network (WLAN), Bluetooth, or a wireless wide area network (WWAN) positioning method, position determination using fluctuations in a detected magnetic field, or a hybrid combination of all the aforementioned systems to produce an accurate location fix.", "The decision by the network enabled location determining device to determine and report a location may be triggered through: an external request over a communication network channel; on a regular timed basis, for example but not limited to one location determination every ten minutes; an external trigger detected by the network enabled device's sensors, for example due to a change in motion detected by the accelerometer or a change in orientation detected by the gyroscopic sensor or magnetometer; a completion of a computation on the network enabled location determining device; or some other internal or external event.", "In some embodiments of the invention the location report may be signed by the network enabled location determining device using an associated public-private key pair, for example using the ECDSA signature scheme, the ElGamal signature scheme, the DSA signature scheme, or some other asymmetric key infrastructure.", "In further embodiments of the invention at least part of the location report may be encrypted using an asymmetric or symmetric cryptographic key generated by the network enabled location determining device, to prevent unauthorized third parties from scanning the shared ledger and extracting the location of the location determining network enabled device at reported times.", "The cryptographic key may then be shared with selected parties in subsequent reports submitted for inclusion in the shared ledger, or the cryptographic key may be encrypted with the public key of a public-private key pair and appended to the location report.", "When the location report is submitted to the peer-to-peer network, a subset of the plurality of network enabled devices associated with the peer-to-peer network may forward copies of the location to a remainder of the plurality of network enabled devices.", "Network enabled devices on the peer-to-peer network may be standard nodes, in that they forward location reports on to other devices on the peer-to-peer network, or they may be “miners”, which are nodes that also perform validation computations on a submitted location report in order to solve a proof-of-work or other computationally difficult problem that confirms to other nodes and miners that the submitted location report should be added to the shared ledger.", "The first of the plurality of network enabled devices to successfully generate a validation computation result may submit this, together with the location report, to the peer-to-peer network.", "The remainder of plurality of network enabled devices may then check the validation computation.", "If it is correct, they may add it to the shared ledger.", "In this manner, the location report is stored in the shared ledger for future retrieval and examination.", "In order to provide an incentive for third parties to join the peer-to-peer network as miners, a commercially-valued credit system may be associated with the described system.", "When the validation computation result and location reports are submitted to the peer-to-peer network by the first of the plurality of network enabled devices, it may also submit a notification that a number of commercially-valued credits are to be credited to a public key of a private-public key pair generated by the first of the plurality of network enabled devices.", "When the remainder of the plurality of network enabled devices add the location report and the validation computation result to the shared ledger, they also add this notification to the shared ledger.", "A submission comprising one or more location reports, a validation computation result and a commercially-valued credit notification will henceforth be described as a “block”.", "The awarding of commercially-valued credits on successfully producing an accepted block provides third parties with a motivation to allocate computing resources and hardware to work on the production of blocks.", "Blocks may also be constructed to comprise a transaction report that reallocates commercially-valued credits from a first public key to a second public key, by signing the transaction report with a private key of the first public key.", "In another embodiment, the location report submitted by the location determining network enabled device may contain an offer of commercially-valued credits that are allocated to a public key of the public-private key pair associated with the location determining network enabled device.", "The commercially-valued credits may then be claimed by the first of the plurality of network enabled devices to produce a block accepted into the public ledger, for example by including a transaction notification in the block that reallocates the commercially-valued credits to the public key of the first of the plurality of network enabled devices.", "Those skilled in the art will further appreciate the advantages and superior features of the invention together with other important aspects thereof on reading the detailed description that follows in conjunction with the drawings." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS The present application is a continuation of, and claims priority of, U.S. non-provisional application Ser.", "No.", "14/981,803, entitled “Peer To Peer Geolocation System”, filed Dec. 28, 2015.The aforementioned United States application is hereby incorporated by reference in its entirety.", "TECHNICAL FIELD The invention relates to computer systems and methods for reporting and recording device locations, and more specifically to the reporting of device locations to a shared file, distributed and maintained over a peer-to-peer network.", "BACKGROUND OF THE INVENTION An entity such as a parent of a child, a haulage company or delivery service, a prison system, or a car rental company, may need to track a location of users or assets, for example but not limited to: ensuring safety, for legal reasons, or in order to secure such assets.", "A common method for reporting and storing location data is in a database connected to a network such as are known from US2014074667.If a location data is recorded in a database maintained by the entity, there are high costs associated with installing and maintaining the hardware and network infrastructure.", "If the location is recorded in a facility maintained by a third party such as a data storage provider, then there is a risk that due to network failure or other technical issues the data storage facility will at some times not be available to be queried by the entity, or to be written to by a location aware device to be tracked by the entity.", "In extreme cases the location data may be irretrievably lost.", "Furthermore, if the database is maintained by the third party, there is a risk that the location data may be revealed to other parties, hacked, corrupted, or otherwise altered, without the knowledge of the entity or possibly the third party.", "It is the intention of the present invention to address the shortcomings of the prior art, i.e.", "the problems of establishing and maintaining a network enabled data storage system, ensuring the integrity of the stored data, and providing always-available data access for users of the system.", "Furthermore, if the method used is based on a distributed system, no individual maintenance costs arise, there is no single point of failure, and through an inherent cryptographic structure integrity is maintained.", "SUMMARY OF THE INVENTION In accordance with the present invention, a solution is provided for reporting, storing and subsequently retrieving the locations of devices or objects in a distributed and secure manner.", "The problems are establishing and maintaining a network enabled data storage system, ensuring the integrity of the stored data, and providing always-available data access for users of the system.", "If the method used is based on a distributed system, no individual maintenance costs arise, there is no single point of failure, and through an inherent cryptographic structure integrity is maintained.", "Embodiments of the invention are based on the reporting of location in a location report by a network enabled location determining device communicating through a peer-to-peer network system to a plurality of network enabled devices.", "A first of the plurality of network enabled devices performs a validation computation on the location report and forwards a result of the validation computation to the plurality of network enabled devices for inclusion in a shared ledger of location reports.", "The network enabled location determining device may include a location module that may comprise a global navigation satellite system receiver (GNSS receiver), a magnetometer, an accelerometer, an altimeter, and a gyroscopic sensor for determining the location of the device.", "Further methods and apparatus for determining the location of the device may include trilateration or time difference of arrival calculations using a wireless local area network (WLAN), Bluetooth, or a wireless wide area network (WWAN) positioning method, position determination using fluctuations in a detected magnetic field, or a hybrid combination of all the aforementioned systems to produce an accurate location fix.", "The decision by the network enabled location determining device to determine and report a location may be triggered through: an external request over a communication network channel; on a regular timed basis, for example but not limited to one location determination every ten minutes; an external trigger detected by the network enabled device's sensors, for example due to a change in motion detected by the accelerometer or a change in orientation detected by the gyroscopic sensor or magnetometer; a completion of a computation on the network enabled location determining device; or some other internal or external event.", "In some embodiments of the invention the location report may be signed by the network enabled location determining device using an associated public-private key pair, for example using the ECDSA signature scheme, the ElGamal signature scheme, the DSA signature scheme, or some other asymmetric key infrastructure.", "In further embodiments of the invention at least part of the location report may be encrypted using an asymmetric or symmetric cryptographic key generated by the network enabled location determining device, to prevent unauthorized third parties from scanning the shared ledger and extracting the location of the location determining network enabled device at reported times.", "The cryptographic key may then be shared with selected parties in subsequent reports submitted for inclusion in the shared ledger, or the cryptographic key may be encrypted with the public key of a public-private key pair and appended to the location report.", "When the location report is submitted to the peer-to-peer network, a subset of the plurality of network enabled devices associated with the peer-to-peer network may forward copies of the location to a remainder of the plurality of network enabled devices.", "Network enabled devices on the peer-to-peer network may be standard nodes, in that they forward location reports on to other devices on the peer-to-peer network, or they may be “miners”, which are nodes that also perform validation computations on a submitted location report in order to solve a proof-of-work or other computationally difficult problem that confirms to other nodes and miners that the submitted location report should be added to the shared ledger.", "The first of the plurality of network enabled devices to successfully generate a validation computation result may submit this, together with the location report, to the peer-to-peer network.", "The remainder of plurality of network enabled devices may then check the validation computation.", "If it is correct, they may add it to the shared ledger.", "In this manner, the location report is stored in the shared ledger for future retrieval and examination.", "In order to provide an incentive for third parties to join the peer-to-peer network as miners, a commercially-valued credit system may be associated with the described system.", "When the validation computation result and location reports are submitted to the peer-to-peer network by the first of the plurality of network enabled devices, it may also submit a notification that a number of commercially-valued credits are to be credited to a public key of a private-public key pair generated by the first of the plurality of network enabled devices.", "When the remainder of the plurality of network enabled devices add the location report and the validation computation result to the shared ledger, they also add this notification to the shared ledger.", "A submission comprising one or more location reports, a validation computation result and a commercially-valued credit notification will henceforth be described as a “block”.", "The awarding of commercially-valued credits on successfully producing an accepted block provides third parties with a motivation to allocate computing resources and hardware to work on the production of blocks.", "Blocks may also be constructed to comprise a transaction report that reallocates commercially-valued credits from a first public key to a second public key, by signing the transaction report with a private key of the first public key.", "In another embodiment, the location report submitted by the location determining network enabled device may contain an offer of commercially-valued credits that are allocated to a public key of the public-private key pair associated with the location determining network enabled device.", "The commercially-valued credits may then be claimed by the first of the plurality of network enabled devices to produce a block accepted into the public ledger, for example by including a transaction notification in the block that reallocates the commercially-valued credits to the public key of the first of the plurality of network enabled devices.", "Those skilled in the art will further appreciate the advantages and superior features of the invention together with other important aspects thereof on reading the detailed description that follows in conjunction with the drawings.", "BRIEF DESCRIPTION OF THE DRAWINGS The components in the figures are not necessarily to scale, emphasis instead being placed upon illustrating the principles of the present invention.", "In the figures, like reference numerals designate corresponding parts throughout the different views.", "FIG.", "1 illustrates a peer-to-peer network with a location determining network enabled device and a plurality of network enabled devices connected to the peer-to-peer network, in accordance with an embodiment of the present invention.", "FIG.", "2 illustrates a location determining network enabled device, in accordance with an embodiment of the present invention.", "FIG.", "3 is a flowchart that shows how the decision to produce a location report by the location determining network enabled device may be made.", "FIG.", "4 is a signal flow diagram providing a general overview of a method controlling the flow of location data from the location determining network enabled device to the plurality of network enabled devices connected via a peer-to-peer network for inclusion in the shared ledger.", "FIG.", "5 is a flowchart that shows an example method for the first of the plurality of network enabled devices to generate and broadcast a validation computation result, according to one embodiment of the invention.", "FIG.", "6 is a block diagram illustrating the structure of a possible embodiment of the blocks in shared ledger.", "FIG.", "7 is a flowchart illustrating a method for including a block containing a location report and a commercially-valued credit allocation in a shared ledger, according to one embodiment of the invention.", "FIG.", "8 is a block diagram illustrating a possible structure of a location report encrypted with a cryptographic key, and with the cryptographic key itself encrypted with a public key and appended to the location report.", "DETAILED DESCRIPTION OF THE INVENTION Aspects of this disclosure will be described in the context of an exemplary system of a plurality of location determining network connected devices and a plurality of network connected devices communicating through the medium of a peer-to-peer network system 100, as shown schematically in FIG.", "1.As depicted, the peer-to-peer network 108 is embodied within a packet switched network 101, through the interconnection of the plurality of network connected devices on the peer-to-peer network 108.A location determining network enabled device 102 may connect to the peer-to-peer network, either through a wireless connection by association with a wireless access point 103 as depicted in FIG.", "1, or alternatively through a cellular base station, a Bluetooth connection, or other wireless connection that provides access to the packet switched network.", "Alternatively, the location determining device may be connected directly to the packet switched network through a wired connection.", "Other devices connected the peer-to-peer network may include network connected devices acting as a “node” 104, 105 whose role is to maintain a list of other devices connected through the peer-to-peer network, and to forward on received network messages to those devices on the list, possibly independently, or possibly as a response to a request from another network connected device.", "As one skilled in the art will be aware, no individual node is required to have a complete list of all devices, as the process of peer-to-peer networking only requires that a union of a set of all nodes contains a complete list of all devices on the peer-to-peer network, and for every pair of network connected devices there is a network route from one device to the other, possibly via a set of one or more nodes.", "Therefore, the only requirement to be a participant on the peer-to-peer network is to establish a connection to one or more of the nodes on said network.", "Further devices connected via the peer-to-peer network may include one or more network connected devices 106, 107 acting as a “miner”, whose role is to receive or request location reports and other transaction messages from the peer-to-peer network, process them according to the methods and processes to be described further below, and transmitting the results of said processing back to the peer-to-peer network for inclusion in a shared ledger.", "The devices described above may each be implemented through a system comprising a one or a plurality of: general purpose microprocessors, digital signal processors (DSPs), application specific instruction set processors (ASIPs), field programmable gate arrays (FPGAs), dedicated application specific integrated chips (ASICs), or other equivalent integrated or discrete logic circuitry and peripheral circuitry, connected to a tangible storage medium containing instructions which when executed effect methods and techniques described below.", "The techniques additionally, or alternatively, may be realized at least in part by a computer-readable communication medium or record carrier, that carries or communicates code in the form of instructions or data structures and that can be accessed, read, and/or executed by a computer.", "An embodiment of the network connected location determining device 102 is presented in FIG.", "2, and is now discussed in further detail.", "The network connected location determining device 102 may comprise a CPU 240 capable of executing instructions stored in a memory 242, and controlling other peripheral components through drivers 244 stored within the memory 242.Further storage 246 may be present.", "Optionally, the network connected location determining device 102 may also include an integrated location determining module, comprising one or more of a global navigation satellite system (GNSS) receiver 222, an antenna 202 for said GNSS receiver 222, and a sensor module 224, connected to one or more of an altimeter 216, a magnetometer 217, a gyroscopic sensor 218, and an accelerometer 219.The integrated location determining module may determine a longitude, a latitude, a heading, a velocity, an acceleration, and an altitude of the network connected location determining device 102 to a degree of accuracy through the use of some or all of these components.", "The network connected location determining device 102 may also include wireless components comprising one or more wireless modules implemented in firmware or hardware, including a wireless local area network (WLAN) module 210 such as a Wi-Fi adapter utilizing an 802.11 protocol, a wireless wide area network (WWAN) module 212 such as GSM, LIE, or other cellular wireless data communication system, or a Bluetooth module 214, each with one or more associated antennas 208, 206 and 204 respectively.", "As desired, one or more antennas may be shared between the modules using switching techniques known to those skilled in the art.", "The wireless components may provide network connectivity to a packet switched network and hence to the peer-to-peer network for the network connected location determining device.", "Alternately the network connected location determining device may be connected to the packet switching network directly through a wired connection.", "The wireless components may also be employed to obtain, or help obtain, a location through techniques such as, but not limited to, time difference of arrival determination of data frames at the wireless component, signal strength determination, signal trilateration, and other wireless position techniques know to those skilled in the art.", "Furthermore, measurements from the wireless components can be used in conjunction with measurements from the GNSS module 222, and the sensor module 224, to provide a hybrid or combined location result.", "Components comprising the network connected location determining device may communicate through a bus 226, which may be implemented as a peripheral component interconnect express (PCIe) bus, a universal serial bus (USB), a universal asynchronous receiver/transmitter (UART) serial bus, a suitable advanced micro-controller bus architecture (AMBA) interface, a serial digital input output (SDIO) bus, or other equivalent interface.", "In FIG.", "3 an exemplary list of possible events, triggers, or occurrences is provided that may cause the network connected location determining device to perform a location determining operation, generate a location report, and send the location report to the peer-to-peer network.", "Event 302 is an internal step and represents a timer event, in which a one-time timer or a repeat timer may be triggered after a pre-set time, causing step 318 to be executed, in which the network connected location determining device 102 generates and sends a location report.", "Event 304 may represent a request from an external entity over the packet switched network for step 318 to be executed.", "The external request may be issued by an owner of the network connected location determining device, or by a user or entity authorized by the owner, or the option to issue the request may be open to any entity.", "Event 306 may represent the network connected location determining device detecting that the accelerometer sensor 219 has experienced a change in output sensor data, reflecting a change in acceleration of the network connected location determining device, and may trigger step 318 to be executed.", "Event 308 may represent the network connected location determining device detecting that the magnetometer sensor 217 has experienced a change in output sensor data, reflecting a change in heading of the network connected location determining device or a movement through a varying magnetic field, and may trigger step 318 to be executed.", "Event 310 may represent the network connected location determining device detecting that the gyroscopic sensor 218 has experienced a change in output sensor data, reflecting a change in heading or a rotation about an internal or external axis of the network connected location determining device, and may trigger step 318 to be executed.", "Event 312 may represent the network connected location determining device detecting that the time difference of arrival of frame data in response to frame request data by the WLAN module 210, the WWAN module 212 or the Bluetooth module 214, has increased or decreased, possibly reflecting a change in the distance of the network connected location determining device from an associated WLAN access point, a WWAN base station or paired Bluetooth device, respectively, and may trigger step 318 to be executed.", "Event 314 may represent the network connected location determining device detecting that its position has changed due to a changing position report from the GNSS module 222, and may trigger step 318 to be executed.", "Event 316 may represent the completion of some other internal computation result, and may trigger step 318 to be executed.", "It will be appreciated by those skilled in the art that although FIG.", "3 shows a logical OR 320 applied to events 302, 304, 306, 308, 310, 312, 314 and 316, any other logical operator or combination or logical operators could be applied.", "For example, the decision to execute step 318 could be undertaken with a logical AND, NOR, or NAND, and applied pairwise to any combination of the events.", "A high level flow diagram illustrating one possible embodiment of the system and the steps taken therein is presented in FIG.", "4.The interaction of the location determining network enabled device 102 with the plurality of network connected devices, and specifically a network connected device functioning as a node 104, and a network connected device functioning as a miner 106, and finally another one of the plurality of network connected devices 107, is shown.", "The flow of a data comprising the location and other associated information determined by the location determining network enabled device through the location report, inclusion in the successfully generated block, and the appending of said block to the shared ledger is also illustrated through FIG.", "4.Once the network connected location determining device 102 has determined a location and other associated data, it may generate a location report 402.The location report may then be encapsulated in a network message 404 and sent on to the peer-to-peer network 406.Once the location report encapsulated in the network message has been received by a network connected device acting as a node 104, the node may forward the message to other network connected devices on the peer-to-peer network 408.Other network connected devices may also make requests to the node for network messages that they have not yet received.", "Through these means, the location report encapsulated in the network message is forwarded to all interested parties on the peer-to-peer network.", "Through these network interactions, the location report encapsulated in the network message may arrive at a network connected device acting as a miner 106.The miner may then extract the location report from the network message as per step 410.After the location report has been obtained, the miner may construct a block containing the location report, a nonce, and any other location reports that the miner has previously received and that have not yet been included in the shared ledger as noted in step 412.The block may also contain other messages and elements, which will be detailed further below.", "The miner may then perform a validation computation on the block 414, further details of which will be provided below.", "For now, it suffices to note that the validation computation will either return a correct result, or a failure as per step 416.If the validation computation returns a failure, the miner may alter the nonce as per step 417, for example if it is an integer by incrementing or decrementing the value of the number by a chosen amount, or by choosing a new random value, and may then repeat the validation computation on the new block as per step 414.If the validation computation is correct, the block has been successfully verified and the miner may transmit it to the peer-to-peer network 418.Through transmission to the peer-to-peer network, the block may arrive at another network connected device 107, which may constitute another miner, or another node.", "The network connected device 107 may then repeat the same validation computation on the block 420 as previously performed by the miner 106 in step 414, and the validation computation will return either a successful result or a failure 422.If the computation result is a failure, the network connected device 107 may discard the block, as shown in step 424.If the validation computation produces a successful result, then the network connected device 107 may add the block to a copy of the shared ledger 426.FIG.", "5 presents a flowchart providing further details for one possible embodiment of a miner, and provides a specification for the steps taken once a location report or a plurality of location reports have been received by a network connected device acting as a miner.", "In step 502 the miner generates a header for a new block, which in one embodiment may contain data indicating the start of the block, and may contain a link back to the last accepted block in the shared ledger, for example through inclusion of a hash of the previous block.", "The header may also contain a time stamp.", "In step 504 the miner may append a message to the block, commonly known to those skilled in the art as a “block reward”, which allocates a number of commercially-valued credits to a public key associated with a network connected device.", "In other embodiments the number of commercially-valued credits may be associated with one or more of: an email address, an IP address or a MAC address.", "In step 506 the miner may append none, one, or a plurality of location reports received from the peer-to-peer network to the block.", "The miner may also append a count of the number of reports added to the block.", "In step 508 the miner may insert a nonce into the block.", "The nonce may comprise a number, a string, or a binary data, and may be selected randomly or according to a predetermined algorithm, for example, the nonce may initially be the number 1, and subsequently incremented by one until a successful result is returned from the validation computation.", "In step 510 the miner may conduct a validation computation on the block in its current state.", "The validation computation may comprise applying a one or more hash functions to the block, and then possibly applying the one or more hash functions or a different one or more hash functions repeatedly one or more times to the output of the previous hash function applied.", "The hash functions used may include SHA, RIPEMD, Whirlpool, Scrypt, HAS-160, or other cryptographic hash function where a hash output cannot be determined from hash input other than by the application of the cryptographic hash function to the hash input.", "A final result of step 510 may be a number.", "In step 512 the final result is compared to a target value.", "The target value may be a fixed value agreed upon by a plurality of participating devices in the peer-to-peer network, or it may be a dynamic value determined in one embodiment by the average time taken for the miners in the peer-to-peer network to produce the last K blocks, where K is a fixed value agreed upon by the plurality of participating devices in the peer-to-peer network.", "When the final result is compared to the target value, the result may be determined to be successful if the final result is greater than the target.", "In other embodiments of the invention the result may be determined to be successful if the final result is greater or equal to the target value, or less than the target value, or less than or equal to the target value, or by some other Boolean operation on the final result and the target value.", "If the result of step 512 is “no”, then step 514 may be executed.", "The miner may alter the nonce in the block, for example by incrementing its value if it is a number, or by selecting a new nonce at random, and may then proceed to step 510 again.", "The repeated cycle of step 510, step 512, and step 514 is often described in the art as a “proof of work” effort.", "If the result of step 512 is “yes”, then step 516 may be executed.", "The miner may append a checksum or cryptographic hash to the block, which allows third parties to verify that the preceding data is correct and has not been altered or corrupted during data transfer.", "Finally, the miner may execute step 520, by sending the completed block to the peer-to-peer network for inspection by other network connected devices, and subsequent inclusion in the shared ledger.", "FIG.", "6 is a diagram defining one exemplary embodiment of a block in terms of elements generated through the process described previously in FIG.", "5.It should be noted that in although the elements for inclusion in the block are presented in a given order in the preferred embodiment detailed above, the chosen ordering within the block may be decided in an arbitrary manner, provided all participants on the peer-to-peer network agree to the same ordering.", "Element 602 is a header, and may comprise: an identifier indicating that the block is intended for a peer-to-peer geolocation system such as is described in this disclosure; a link to the preceding block, for example through a block number identifier or a cryptographic hash of the preceding block; a time stamp.", "Element 604 is an integer indicating the block size.", "Element 606 is a nonce.", "Element 608 is a commercially-valued credit allocation message, and may include a claim to a number of commercially-valued credits to be allocated.", "Element 610 is an integer indicating the number of location reports included in the block.", "It can be zero, or an integer greater than zero.", "In FIG.", "6 an example is presented in which N location reports are included in the block.", "Element 612 is an example of a first location report received from the peer-to-peer network and included in the block.", "Element 614 is an example of a second location report received from the peer-to-peer network and included in the block.", "Element 616 is an example of an Nth location report received from the peer-to-peer network and included in the block.", "Element 618 is an integer indicating a number of transaction messages may be included in the block.", "It can be zero, or an integer greater than zero.", "In FIG.", "6 an example is presented in which M transaction messages are included in the block.", "A transaction message may represent a transfer of commercially-valued credits from an allocation to a one public cryptographic key to an allocation to a second public cryptographic key, and may be signed with a private cryptographic key to authorize the transfer.", "Element 620 is an example of a first transaction message received from the peer-to-peer network or generated by the miner and included in the block.", "Element 622 is an example of a second transaction message received from the peer-to-peer network or generated by the miner and included in the block.", "Element 624 is an example of a Mth transaction message received from the peer-to-peer network or generated by the miner and included in the block.", "In a preferred embodiment of the invention, elements 602 through 624 may be cryptographically hashed during the validation computation in the proof of work activity to provide a final result for comparison with the target value.", "Element 626 is a checksum or cryptographic hash of elements 602 through 624 that may be included in the block, for example to allow third parties to verify that the preceding data is correct and has not been altered or corrupted during data transfer.", "In one embodiment it may be the result obtained from the proof of work activity during the validation computation.", "One possible embodiment of a network connected device, henceforth referred to as a verifier, for verifying a block submitted to the peer-to-peer network by a miner is presented in FIG.", "7.In step 702 the network connected device may receive the block from the peer-to-peer network.", "In step 704 the verifier may perform a same validation computation on the submitted block, as performed by the miner.", "In step 706 the verifier may examine a result to determine if the block satisfies the validation computation.", "If the result is “no”, the network connected device may proceed to step 708, in which the block is discarded.", "If the result is “yes”, the network connected device may proceed to step 710, in which the shared ledger may be scanned for location reports or transaction messages matching those in the submitted block.", "The result from step 710 may be evaluated by the verifier in step 712.If the result of step 712 is “yes”, then duplicates have been found, and the verifier proceeds to step 708, in which the block is discarded.", "If the result of step 712 is “no”, then no duplicates were found, and the verifier proceeds to step 714, in which the block is added to the shared ledger.", "FIG.", "8 presents a possible embodiment of a location report message.", "The location report header 802 may contain a marker indicating that the rest of the message contains a location report, and other header information such as the length of the report.", "The location report may contain the public key 804, the network address 806 and the email address 808 of the network connected location determining device 102 that is to submit the location report.", "A data payload of the location report may comprise a longitude 812, a latitude 814, an altitude 816, a time of position determination 818, and a position accuracy 820.The data payload may be encrypted with a cryptographic symmetric key 810, for example to maintain the privacy of the location determined by the network connected location determining device.", "The location report may also comprise the symmetric key of 810 encrypted with a public key 822 of an alternate network connected device.", "This may allow the alternate network connected device to decrypt the symmetric key using its private key, and subsequently decrypt the data payload 812-820, using the decrypted symmetric key.", "The location report may also comprise a digital signature 824, generated with the private key of the network connected location determining device, in order to provide for the veracity of the submitted location report.", "As will be appreciated from the above discussion, an advantage of the systems and methods of this disclosure includes distributing effort required to maintain and extend a shared ledger, a file, or a database of location information pertaining to a plurality of network connected location determining devices, thereby providing protection from an existence of a single point of failure, and reducing cost to individual users of the system.", "Further, these techniques offer protection of the location data stored through use of cryptographic keys and digital signatures.", "Finally, the techniques also allow for rewarding of owners of network connected devices participating in the peer-to-peer network and charging of owners or users of network connected location determining devices providing location reports to the system." ] ]
Patent_15876122
[ [ "DENTAL TAPE AND FLOSS HOLDER WITH INSTALLATION CASSETTE", "A floss holder includes a housing and a spindle for receiving floss and a fork having two ends between which the feed portion of the floss is secured for use.", "A first locking plate is operable for receiving a feed portion and a return portion of the floss upon a horizontal surface thereof.", "A second locking plate is operable to engage the first locking plate, where a distal end of the second locking plate engages the feed portion and the return portion to substantially constrain the feed portion of the floss on the fork and the return portion, applying tension along the feed portion and the return portion.", "A number of protrusions assist in retaining the feed portion and preventing the tape floss from slippage while reducing the friction around the fork; the protrusions are located at the base of the fork and inside the floss holder." ], [ "1.A dental floss holder comprising: (a) a housing comprising a first part and a second part forming in a closed position a fork having two prongs for receiving a feed portion of floss and an aperture on a side of the housing opposite to the fork for enabling a return portion of floss to exit the housing; (b) a spindle or spool contained in the housing, said spindle or spool being operable for receiving a quantity of floss wound thereabout; (c) a first toothed locking plate disposed in the housing, said the first toothed locking plate capable of receiving the feed portion and the return portion returning back over a substantially horizontal surface of the first toothed locking plate; (d) a second toothed locking plate positioned between the first toothed locking plate and a locking button disposed in the housing, said locking button protruding through the housing so as to enable selective operation by a user, wherein teeth of the first locking plate and teeth of the second locking plate are selectively engaged by a user by moving the locking button towards the fork, whereby a distal end of the second toothed locking plate proximate to the fork engages the feed portion of the floss and the return portion of the floss returning back over the substantially horizontal surface to substantially restrain the feed portion and the return portion between the first toothed locking plate and the second toothed locking plate, wherein the act of selectively engaging the locking butting applies a tension force to the feed portion between the two prongs of the fork and the return portion; and (e) a cutting blade connected to the housing for cutting the return portion.", "2.The dental floss holder of claim 1, wherein the locking button includes a plurality of protrusions and a combined thickness of the first toothed locking plate, the second toothed locking plate, and each of the plurality of protrusions is greater than a distance between elements and protruding elements of the housing.", "3.The dental floss holder of claim 2, wherein the plurality of protrusions lodge between and thereby engage elements and protruding elements of the housing when the locking button is selectively moved towards the fork.", "4.The dental floss holder of claim 2, wherein each of the plurality of protrusions is wedge- or parallelogram-shaped.", "5.The dental floss holder of claim 1, wherein the housing includes a plurality of housing protrusions on the first part and a plurality of housing protrusions on the second part, about which floss moves, creating a plurality of contact points between the floss and the housing, thereby reducing friction between the floss and the housing.", "6.The dental floss holder of claim 5, wherein one of the plurality of housing protrusions on the first part is disposed at the base of the fork and wherein one of the plurality of housing protrusions on the second part is symmetrically disposed on the other side of the base of the fork.", "7.The dental floss holder of claim 1, wherein each prong of the fork includes an end for facilitating the smooth movement of floss between the prongs.", "8.The dental floss holder of claim 7, wherein the ends are substantially cylindrical or semi-cylindrical.", "9.The dental floss holder of claim 1, wherein each prong of the fork includes a pair of extensions having a space between each of the pair of extensions, each said pair of extensions being positioned to retain the floss during inserting, removing, and flossing.", "10.The dental floss holder of claim 9, wherein the space between each of the pair of extension enables a user to reposition floss between prongs of the fork if the floss tears or slips.", "11.The dental floss holder of claim 1, wherein the cutting blade is recessed below a surface of the housing.", "12.The dental floss holder of claim 1, wherein the tension force to the feed portion between and the return portion is applied by a horizontal element of the locking button sliding between the distal end of the second toothed locking plate and the protruding elements when selectively engaged by the user.", "13.The dental floss holder of claim 1, wherein the locking button is a sliding button.", "14.The dental floss holder of claim 1, wherein the distal end of the second toothed locking plate includes at least one notch for engaging the feed portion or the return portion.", "15.The dental floss holder of claim 1, wherein the first part or the second part includes a plurality of fixating plates holding together the first part and the second part.", "16.The dental floss holder of claim 1, wherein the housing includes a seam between the first part and the second part, said seam acting as a hinge or pivot, and wherein the housing is selectively openable by a user to install or replace a quantity of floss by pivoting the first part away from the second part.", "17.The dental floss holder of claim 1, wherein the first toothed locking plate or the second toothed locking plate includes a partition wall aligned with a longitudinal axis of the housing to separate the feed portion and the return portion.", "18.The dental floss holder of claim 1, further comprising a locking means for holding together the first part and the second part.", "19.The dental floss holder of claim 18 wherein the locking means are selected from the group consisting from latches, locks, snaps, straps, hook and loop attachments, and rails.", "20.A dental floss holder comprising: (a) a housing comprising a first part and a second part forming in a closed position a fork having two prongs for receiving a feed portion of floss and an aperture on a side of the housing opposite to the fork for enabling a return portion of floss to exit the housing, wherein each prong of the fork includes a channel for passing the feed portion and the return portion; (b) a cassette contained in the housing, said cassette having a bottom part including a container and a first toothed locking plate connected to the container, said first toothed locking plate capable of receiving the feed portion and the return portion over a substantially horizontal surface of the first toothed locking plate, and a top part including a cover, forming a closable container with the container for holding a spindle or spool being operable for receiving a quantity of floss wound thereabout and a second toothed locking plate connected to the cover, said second toothed locking plate being positioned between the first toothed locking plate and a locking button disposed in the housing, said locking button protruding through the housing so as to enable selective operation by a user, wherein teeth of the first locking plate and teeth of the second locking plate are selectively engaged by a user by moving the locking button towards the fork, whereby a distal end of the second toothed locking plate proximate to the fork engages the feed portion of the floss and the return portion of the floss returning back over the substantially horizontal surface to substantially restrain the feed portion and the return portion between the first toothed locking plate and the second toothed locking plate, wherein the act of selectively engaging the locking butting applies a force to the first toothed locking plate and the second toothed locking plate and a tension force to the feed portion between the two prongs of the fork and the return portion; and (c) a cutting blade connected to the housing for cutting the return portion." ], [ "<SOH> BACKGROUND <EOH>The present invention relates to a dental floss holder.", "Daily flossing is highly recommended by dentists for good oral health.", "However, many people do not practice daily flossing.", "Some people do not floss because the floss can be difficult to use as it may break, tangle or pinch the fingers during use.", "It is therefore an objective of the present invention to provide a device that holds dental floss during use.", "Currently, dental floss holders exist.", "However, when using these dental floss holders it is often difficult to hold the floss firmly in the desired position.", "Also, the floss may stretch or become tangled during flossing or when removing used floss from the holder.", "Furthermore, many dental floss holders require the user to install a piece of floss in the holder before each use or are not reusable and are thrown away after one use.", "Some floss holders accept only limited types of floss and may not be suitable for using dental tape and flosses using modern technologies.", "Some floss holders require large pieces of floss to be replaced at a time, creating waste.", "In other floss holders replacing is time-consuming and the floss can be tangled or twisted.", "Yet other floss holders are designed for right hand users and are not as equally convenient for left hand users.", "Still other floss holders are not designed for easy access to all areas in the mouth.", "In view of the foregoing, there is a need for improved techniques for providing a dental floss holder that firmly holds the floss, generally prevents the floss from stretching, bunching up, or becoming tangled and is easily reused." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>This invention meets the need for an improved dental holder/flosser by providing a device that securely holds the floss, allows the user to easily replace the used section of floss with a fresh section of floss, and prevents the floss from stretching or bunching up.", "At the same time, the novel improved dental floss holder/flosser is easy to operate, inexpensive to manufacture, and it addresses the issues present in the dental floss holders/flossers known in the art.", "The novel dental floss holder/flosser achieves that by having an innovative securing/locking system for the floss and elements that reduce friction and sticking and promote uninhibited movement of the floss through the device." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation-in-part of the nonprovisional patent application Ser.", "No.", "13/825,321, which claims priority benefit under 35 U.S.C.", "§ 120 and § 365(c) of the PCT international patent application designating the U.S. Ser.", "No.", "PCT/US11/52066, filed 18 Sep. 2011, entitled “Dental Tape and Floss Holder with Installation Cassette”, and this application further claims benefit of priority under 35 U.S.C.", "§ 119(e) to U.S. provisional patent application Ser.", "No.", "61/403,635, filed Sep. 20, 2010, entitled “Dental Floss Holder with Installation Cassette,” the disclosures of all of which are incorporated herein by reference in their entirety for all purposes to the extent that such subject matter is not inconsistent herewith or limiting hereof.", "FIELD OF THE INVENTION This invention was not made pursuant to any federally-sponsored research and/or development.", "A portion of the disclosure of this patent document contains material that is subject to copyright protection.", "The copyright owner has no objection to the facsimile reproduction by anyone of the patent document or patent disclosure as it appears in the Patent and Trademark Office, patent file or records, but otherwise reserves all copyright rights whatsoever.", "The present invention relates generally to dental care.", "More particularly, the invention relates to a dental floss holder, which is usable by any person to floss and is easily operable to move and replace the portion of the floss that has been used with a fresh section of floss.", "BACKGROUND The present invention relates to a dental floss holder.", "Daily flossing is highly recommended by dentists for good oral health.", "However, many people do not practice daily flossing.", "Some people do not floss because the floss can be difficult to use as it may break, tangle or pinch the fingers during use.", "It is therefore an objective of the present invention to provide a device that holds dental floss during use.", "Currently, dental floss holders exist.", "However, when using these dental floss holders it is often difficult to hold the floss firmly in the desired position.", "Also, the floss may stretch or become tangled during flossing or when removing used floss from the holder.", "Furthermore, many dental floss holders require the user to install a piece of floss in the holder before each use or are not reusable and are thrown away after one use.", "Some floss holders accept only limited types of floss and may not be suitable for using dental tape and flosses using modern technologies.", "Some floss holders require large pieces of floss to be replaced at a time, creating waste.", "In other floss holders replacing is time-consuming and the floss can be tangled or twisted.", "Yet other floss holders are designed for right hand users and are not as equally convenient for left hand users.", "Still other floss holders are not designed for easy access to all areas in the mouth.", "In view of the foregoing, there is a need for improved techniques for providing a dental floss holder that firmly holds the floss, generally prevents the floss from stretching, bunching up, or becoming tangled and is easily reused.", "SUMMARY OF THE INVENTION This invention meets the need for an improved dental holder/flosser by providing a device that securely holds the floss, allows the user to easily replace the used section of floss with a fresh section of floss, and prevents the floss from stretching or bunching up.", "At the same time, the novel improved dental floss holder/flosser is easy to operate, inexpensive to manufacture, and it addresses the issues present in the dental floss holders/flossers known in the art.", "The novel dental floss holder/flosser achieves that by having an innovative securing/locking system for the floss and elements that reduce friction and sticking and promote uninhibited movement of the floss through the device.", "BRIEF DESCRIPTION OF THE DRAWINGS The present invention is illustrated by way of examples, in the figures of the accompanying drawings in which reference numerals refer to elements.", "The features, aspects and advantages of the novel invention will become further understood with reference to the following description and accompanying drawings where FIG.", "1 is a perspective view of the dental floss holder in accordance with an embodiment of the present invention; FIG.", "1A is a side view of the dental floss holder of FIG.", "1; FIG.", "1B is a front view of the dental floss holder of FIG.", "1; FIG.", "1C is a rear view of the dental floss holder of FIG.", "1; FIG.", "1D is a perspective close-up view of the fork of the dental floss holder of FIG.", "1; FIG.", "2A is perspective view of the dental floss cassette, in a closed position, used with an alternative embodiment of the dental floss holder, illustrating the water-resistant container for floss in a closed position; FIG.", "2B is a perspective view of the floss cassette of FIG.", "2A in an open position, illustrating the locking plates of the dental floss holder and the water-resistant container for floss in an open position; FIG.", "3A is a perspective view of a preferred embodiment of a locking button of the dental floss holder of FIG.", "1; FIG.", "3B is a front view of the locking button of FIG.", "3A; FIG.", "3C is the bottom view of the locking button of FIG.", "3A; FIG.", "4A is a side view of the alternative embodiment of the dental floss holder in the open position, containing the locking button of FIG.", "3A, the floss cassette of FIG.", "2A and a blade mounted on the dental floss holder; FIG.", "4B is a perspective view of the dental floss holder of FIG.", "4A in the open position with the locking button, the floss cassette and the blade removed; DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention is best understood by reference to the detailed figures and description set forth herein.", "Various embodiments of the invention are discussed below with reference to the Figures.", "However, those skilled in the art will readily appreciate that the detailed description given herein with respect to these figures is for explanatory purposes as the invention extends beyond these limited embodiments.", "For example, it should be appreciated that those skilled in the art will, in light of the teachings of the present invention, recognize a multiplicity of alternate and suitable approaches, depending upon the needs of the particular application, to implement the functionality of any given detail described herein, beyond the particular implementation choices in the following embodiments described and shown.", "That is, there are numerous modifications and variations of the invention that are too numerous to be listed but that all fit within the scope of the invention.", "Also, singular words should be read as plural and vice versa and masculine as feminine and vice versa, where appropriate, and alternative embodiments do not necessarily imply that the two are mutually exclusive.", "It is to be further understood that the present invention is not limited to the particular methodology, compounds, materials, manufacturing techniques, uses, and applications, described herein, as these may vary.", "It is also to be understood that the terminology used herein is used for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention.", "It must be noted that as used herein and in the appended claims, the singular forms “a,” “an,” and “the” include the plural reference unless the context clearly dictates otherwise.", "Thus, for example, a reference to “an element” is a reference to one or more elements and includes equivalents thereof known to those skilled in the art.", "Similarly, for another example, a reference to “a step” or “a means” is a reference to one or more steps or means and may include sub-steps and subservient means.", "All conjunctions used are to be understood in the most inclusive sense possible.", "Thus, the word “or” should be understood as having the definition of a logical “or” rather than that of a logical “exclusive or” unless the context clearly necessitates otherwise.", "Structures described herein are to be understood also to refer to functional equivalents of such structures.", "Language that may be construed to express approximation should be so understood unless the context clearly dictates otherwise.", "Unless defined otherwise, all technical and scientific terms used herein have the same meanings as commonly understood by one of ordinary skill in the art to which this invention belongs.", "Preferred methods, techniques, devices, and materials are described, although any methods, techniques, devices, or materials similar or equivalent to those described herein may be used in the practice or testing of the present invention.", "Structures described herein are to be understood also to refer to functional equivalents of such structures.", "The present invention will now be described in detail with reference to embodiments thereof as illustrated in the accompanying drawings.", "From reading the present disclosure, other variations and modifications will be apparent to persons skilled in the art.", "Such variations and modifications may involve equivalent and other features which are already known in the art, and which may be used instead of or in addition to features already described herein.", "Although Claims have been formulated in this Application to particular combinations of features, it should be understood that the scope of the disclosure of the present invention also includes any novel feature or any novel combination of features disclosed herein either explicitly or implicitly or any generalization thereof, whether or not it relates to the same invention as presently claimed in any Claim and whether or not it mitigates any or all of the same technical problems as does the present invention.", "Features which are described in the context of separate embodiments may also be provided in combination in a single embodiment.", "Conversely, various features which are, for brevity, described in the context of a single embodiment, may also be provided separately or in any suitable sub combination.", "The Applicants hereby give notice that new Claims may be formulated to such features and/or combinations of such features during the prosecution of the present Application or of any further Application derived therefrom.", "As is well known to those skilled in the art many careful considerations and compromises typically must be made when designing for the optimal manufacture of a commercial implementation any system, and in particular, the embodiments of the present invention.", "A commercial implementation in accordance with the spirit and teachings of the present invention may configured according to the needs of the particular application, whereby any aspect(s), feature(s), function(s), result(s), component(s), approach(s), or step(s) of the teachings related to any described embodiment of the present invention may be suitably omitted, included, adapted, mixed and matched, or improved and/or optimized by those skilled in the art, using their average skills and known techniques, to achieve the desired implementation that addresses the needs of the particular application.", "Detailed descriptions of the preferred embodiments are provided herein.", "It is to be understood, however, that the present invention may be embodied in various forms.", "Therefore, specific details disclosed herein are not to be interpreted as limiting, but rather as a basis for the claims and as a representative basis for teaching one skilled in the art to employ the present invention in virtually any appropriately detailed system, structure or manner.", "It is to be understood that any exact measurements/dimensions or particular construction materials indicated herein are solely provided as examples of suitable configurations and are not intended to be limiting in any way.", "Depending on the needs of the particular application, those skilled in the art will readily recognize, in light of the following teachings, a multiplicity of suitable alternative implementation details.", "A preferred embodiment of the present invention and some variations thereof provide a dental floss holder, which may be used with conventional round floss or dental tape.", "Some preferred embodiments allow for the use of many types of floss including, but not limited to, round floss, dental tape, flosses using modern technologies developed for new applications of synthetic materials with elastic effect, ultra-thin floss, wax covered floss, etc.", "Some preferred embodiments may be designed to enable them to be produced from plastic with existing technologies used for manufacturing containers for conventional dental flosses and tapes.", "Some types of dental tape floss include monofilament nylon, polytetrafluoroethylene (PTFE), and microfilament floss.", "However, some alternate embodiments may be produced using different techniques and from different materials including, but not limited to, metals, composites, rubber, or a combination of materials.", "Some preferred embodiments comprise a small number of parts, which allows for quick and easy installation of the floss and generally ensures minimum costs in the production of the device.", "With reference to FIGS.", "1, 1A, 1B and 1C an exemplary dental floss holder is illustrated in accordance with an embodiment of the present invention.", "In the present embodiment, the floss holder is preferably made for effective use of dental tape.", "However, the floss holder also allows for the use of conventional round floss, waxed floss, ultra-thin floss, synthetic floss, elastic floss, etc.", "In the present embodiment, the floss holder comprises a housing 2, an optional floss cassette 4, as shown by way of example in FIGS.", "2A, 2B and 2C, a locking button 1, which locks a stretched portion of floss 5 within a locking mechanism in housing 2, and a rounded blade 3.The housing 2 is preferably a one-piece part manufactured from plastic, which may be injection-molded.", "The housing 2 has a first part 6 and a second part 7 THESE PARTS NEED TO BE SHOWN IN THE DRAWINGS, which are essentially symmetrical versus one another about a longitudinal axis of the housing 2 and can pivot to grant access to the interior of the housing 2 and the floss cassette 4.Alternatively, the first part and the second part may be called a left side and right side of the housing 2 or top part and bottom part of the housing 2.A person skilled in the art will appreciate that the housing may be manufactured several different ways to satisfy these requirements.", "The design of floss holder housing 2 and particularly a fork 204 comprising fork-shaped protruding prongs 8 PRONGS 8 and base 9 must be shown in the drawings enables smooth flossing by holding a piece of floss 5 firmly in the desired position and generally preventing floss 5 from stretching and tangling during flossing or while removing used floss.", "Indent 217 on housing 2 enables the user to rest the floss holder on a finger while operating locking button 1 to prevent the floss holder from slipping.", "As illustrated in FIG.", "1D, the ends 210 of the fork 204 are substantially cylindrical and are positioned so that floss, especially tape floss, passes between the ends 210 smoothly, with little friction, and without bunching up because it passes between the side walls of the ends 210, each of which side wall (curvilinear shape) is located between the respective cylinder's faces.", "In the preferred embodiment of this invention, the ends 210 are molded into the fork 204 (i.e., in the shape of a half-cylinder or semi-cylinder where the floss comes into contact with the curvilinear shape), but the ends 210 may be separate cylindrical pins inserted into the fork 204, which may be solid or hollow.", "Bunching up of the floss is a known problem with the existing flossing devices that use V-shaped cutouts or apertures to thread the floss through, which pulls the floss into one point and thickens the floss material.", "This in turn makes it difficult to or unavailable for use by users with closely-placed teeth (i.e., who have tight gaps between the teeth).", "The present invention addresses these issues with the substantially cylindrical ends 210 that allow tape floss to retain its intended shape and expand even multi-thread or string floss, approximating it to tape floss.", "The ends 210 are designed to keep the wide tape floss in good shape (smoothing the operation and preserving the qualities of the material during refreshing and flossing process by the user and avoiding the effect of folds in two, twisting and compression effect between the prongs 8 of the fork).", "Tape floss is usually thin, allowing the user to floss even if the gaps between the teeth and minimal, and tape floss is more effective than string floss because tape floss covers a greater surface of the tooth in use.", "Bunched-up tape floss loses these advantageous qualities, but the present invention allows tape floss to retain its intended structure and capabilities.", "Further with reference to FIG.", "1D, the extensions 209, which are preferably positioned on both sides of the ends 210, retain the floss on the ends 210 of the fork 204, even during aggressive use, especially the stress on the floss during the process of entry into or removal of the floss from the space between the teeth.", "Because there is open space between extensions 209, the user can replace the floss back onto the ends 210 of the fork 204 in the event the floss tears, without having to thread the floss through apertures that exist in prior flossing devices.", "A free end 5A of floss 5 is pulled out through an opening 207, which enables a user to pull floss 5 through the floss holder after housing 2 is locked in a closed position.", "In the present embodiment, opening 207 is located at the end of housing 2 opposite fork 204.However, this opening 207 may be placed in various different locations in alternate embodiments such as, but not limited to, on the front or side of the housing.", "In the present embodiment, housing 2 is held in place in the closed position with two housing fixating plates 201, which are locked firmly in place with the help of a locking mechanism, shown by way of example in FIG.", "4B.", "The locking mechanism of the fixating plates 201 may be a latch, lock, snap, or similar locking mechanism.", "These are the preferred attachment methods, although other methods, including straps, hook and loop attachments, or rails may be used.", "To open housing 2, fixating plates 201 are unlocked and the two portions of housing 2 are spread apart along a seam 213 on the back with a hinge 214 on the front.", "Free end 5A of floss 5, which is the used portion of floss 5, is manually pulled through opening 207 and into a channel 215, which guides free end 5A in the direction of cutting blade 3 where the used portion of floss 5 is cut off Alternate embodiments may be implemented without a channel for guiding the free end of the floss and also be implemented without a blade.", "In the present embodiment, housing protrusions 208, which are also located on the inside of housing 2 as shown by way of example in FIG.", "4B, reduce friction on floss 5 in the process of sliding floss 5 through the floss holder when the used portion is replaced with a clean portion.", "Dimples 216 enable a user to firmly grasp housing 2 when floss 5 is manually pulled through opening 207 and into a channel 215 and capture free end 5A in the process of cutting by the blade 3.Housing protrusions 208 reduce friction by creating several points of contact between the floss tape and the floss holder along the path of the floss tape's movement.", "When the floss tape is moved (i.e., to get a fresh, unused portion of the floss between the ends 210 of the fork 204, the use of housing protrusions 208 avoids the undesirable effect of sticking of some types of floss (depending on the material) to the floss holder, and particularly sticking to the prongs 8 of the fork 204.This is especially important for tape floss that has a large contact surface area, or floss that is treated with flavor components, wax, or medicinal additives.", "CANNOT SEE the housing protrusions 208 that well, need a drawing similar to page 3 (top view cross section).", "In the present embodiment, the floss holder is designed to allow equally easy operation for left or right-handed users.", "For example, without limitation, dimples 216 and channels 215 are provided on both sides of housing 2 to enable the used portion of floss 5 to be cut on either side of housing 2.However, alternate embodiments may be implemented as specifically right-handed or left-handed devices.", "In the present embodiment, the floss holder provides considerable savings of floss since during the replacement of floss 5 on the fork 204 only about one to one and a half inches of floss are used.", "Also, the process of replacing floss 5 is fast and simple, often taking only one to two seconds to complete.", "The floss holder is designed so that the clean portion of floss 5 does not come into contact with the used portion at any time during flossing or during the replacement of floss 5 on the fork 204.FIGS.", "2A and 2B illustrate an exemplary floss cassette 4 from a dental floss holder, in accordance with an embodiment of the present invention.", "FIG.", "2A is a side perspective view of floss cassette 4 in a closed position.", "In the present embodiment floss 5 is installed in floss cassette 4 by being coiled around a cylinder 406 then being fed between locking plates 401 and 402 around a plate 404 and a plate portion 404A.", "In some embodiments, plate portion 404A includes a notch 412, shown in FIG.", "4B, to capture floss 5.In other alternate embodiments, various other means may be used to capture floss 5.From here, floss 5 is placed back through locking plates 401 and 402 then into one of notches 409 and out of cassette 4 so that a free end 5A of floss 5 can exit the floss holder once cassette 4 is installed in the floss holder, as shown by way of example in FIG.", "4A.", "Further with reference to FIGS.", "2A and 2B, the floss cassette 4 includes the water-resistant container 421 and the cover 422 of the water-resistant container 421.The water-resistant container 421 houses the spindle or spool of the floss inside the housing 2, and the user accesses the water-resistant container 421 by separating the top and the bottom parts of the floss cassette 4 to lift the cover 422 off the water-resistant container 421.As disclosed in this specification, the floss may be coiled around a cylinder 406 integral to the interior of the water-resistant container 421.With reference to FIG.", "2B, the partition wall 420 is an optional partition, located in either locking plate 401 as illustrated, but may also be located in the locking plate 402, preferably on the middle longitudinal axis of the plate.", "The partition wall 420 serves as a separator between the feed portion of the floss (clean, unused floss on the way to the fork 204) and the return (used floss on the way back to the end of the housing 2 opposite to the fork 204, where the return exits the housing 2 through an aperture in the housing.", "The partition wall 420 ensures that the used floss of the return does not come into contact and contaminate the clean, unused floss in the feed portion.", "Floss cassette 4 comprises a stretching mechanism 403, which holds floss 5 in place and stretches floss 5 on the fork 204 of the floss holder and maintains floss 5 in the stretched position for smooth and easy flossing, as described by way of example in accordance with FIG.", "4A.", "The stretching mechanism 403 illustrated in FIG.", "4A is essentially a curved extension on the end of the locking plate 401 proximate to the fork 204 (i.e., the distal end of the locking plate 401).", "The stretching mechanism 403 may include one or two notches for engaging one or both of the feed portion of the floss and the return portion of the floss when the stretching mechanism 403 is engaged by sliding the locking button 1 towards the fork 204.In order for floss 5 to be coiled around cylinder 406, a user may manually wind a long piece of floss around cylinder 406 or a pre-wound spool of floss may be placed on cylinder 406.In some embodiments the cassette 4 may be preloaded with floss.", "In these embodiments, the user may obtain the cassette preloaded with a type of floss of his/her choosing.", "During the installation in the present embodiment, protruding segments 407 hold floss 5 in place on locking plate 402.After floss 5 is installed in cassette 4, cassette 4 is inserted into the housing of the floss holder.", "Openings 405 on locking plates 401 and 402 are installed upon protrusions inside the housing, shown by way of example in FIGS.", "4A and 4B.", "In the present embodiment, locking plates 401 and 402 comprise zigzagged surfaces with a multiplicity of protrusions (toothed surfaces if viewed in a cross-section).", "In alternate embodiments the zigzagged surface may only be on locking plate 401 or only on locking plate 402.The number of protrusions and corresponding hollow segments on locking plates 401 and 402 depends on the size of the floss holder.", "In alternate embodiments only one of the locking plates may have a zigzagged surface or the surfaces may have different textures such as, but not limited to, a bumpy or rough texture.", "Plates 410 on the top portion of cassette 4 and plate 401 provide unlocking of locking plates 401 and 402, as described by way of example in accordance with FIG.", "4A.", "The plates 410 are shown in FIGS.", "2A, 4A and 4B on the rear part of plate 401.FIGS.", "3A, 3B and 3C illustrate an exemplary locking button 1 of a dental floss holder, in accordance with an embodiment of the present invention.", "FIG.", "3A is a side perspective view.", "FIG.", "3B is a front view, and FIG.", "3C is a bottom view.", "In the present embodiment, locking button 1 comprises an irregular bottom surface with protrusions 101 extending from a horizontal element 102.When locking button 1 is installed in the floss holder, pushing forward on locking button 1 (sliding the locking button 1 forward towards the fork) causes the floss in the floss holder to be held in place.", "As illustrated in FIG.", "3A, the protrusions 101 are preferably parallelogram-shaped, but they may be wedge- or substantially triangular-shaped.", "In use, when the tape floss slides under the protruding elements 206, protrusions 101 of the locking button 1 cause the deformation of the space between protruding elements 206 and elements 212, causing high pressure on the floss material between the locking plates 401 and 402.This happens because of the one-piece injection molded plastic between protruding elements 206 and elements 212 that creates tension when deformed (stretched) because it is trying to return to its initial shape, which is defined by the injection molding form.", "This innovative solution allows to hold the floss by blocking it from moving without any additional exertion of force by the user (such as, for example, by pinching it in the hand, holding the blocking button, or any other restrictive manipulations that would limit the user's ability to freely use the floss holder).", "To achieve this effect, the distance between elements 212 and protruding elements 206 should be less than the combined thickness of toothed plates 401, 402 and protrusions 101 of the locking button 1 (the thickness of the protrusions 101 is basically the height of the protrusions 101).", "For example, if the combined thickness of toothed plates 401, 402 and protrusions 101 is 7.5 mm, the distance between elements 212 and protruding elements 206 should be 7.0 mm.", "Furthermore, horizontal element 102 of the locking button 1 generates pressure on the stretching mechanism 403, which exerts pressure onto the floss material (both the fresh, unused floss coming out of the blocking plates 401 and 402 and the return, used floss coming into the plates).", "Therefore, the tensioning of the floss materials happens directly on the fork 204 of the dental floss holder.", "Elements 101 generate equal pressure along the entire lengths of the locking toothed plate 401, which ensures effective retention of the floss material.", "FIGS.", "4A and 4B illustrate an exemplary dental floss holder, in accordance with an embodiment of the present invention.", "FIG.", "4A is a side view of the floss holder in an open position, and FIG.", "4B is a side perspective view of the floss holder in the open position with a locking button 1, a floss cassette 4 and a blade 3 removed.", "In the present embodiment, a housing 2 opens by pivoting at a hinge 214.In alternate embodiments, the housing may comprise two halves that are separate from each other that snap together to close.", "Other alternate embodiments may comprise doors that swing open, slide open, or snap on and off of the housing to provide access to the inside of the housing to load the floss.", "Referring to FIG.", "4A, after the installation of floss 5, cassette 4 is closed and inserted into housing 2 of the floss holder.", "In the present embodiment, floss cassette 4 is slid into the side of housing 2; however, alternate embodiments may be implemented where the floss cassette is installed in different ways for example, without limitation, dropped in from the top or bottom of the housing.", "Referring to FIGS.", "4A and 4B, in the present embodiment, a protrusion 212 provides stable positioning for plates 410 on the front of cassette 4.Element 212 is also an element providing the stable positioning for plate 402 inside of housing 2.Openings 405 on locking plates 401 and 402 of cassette 4 are installed upon protrusions 211 inside housing 2 and hold and stabilize locking plate 401 over locking plate 402.Once floss cassette 4 is in place, locking button 1 is installed above floss cassette 4.An opening 207 in housing 2 enables a user to pull a free end 5A of floss 5 out of housing 2 so that the used portions of floss 5 can be replaced with clean floss when floss locking plates 401 and 402 are unlocked, as shown by way of example in FIG.", "4A.", "The portion of floss 5 around a plate 404 is installed on the fork 204 of the floss holder once housing 2 is closed.", "Referring to FIG.", "4B, in the closed position, housing 2 is held closed by two fixating plates 201, which are locked firmly in place by locking mechanisms 202 locking into openings 203 on the opposite end of housing 2.The locking mechanism 202 of the fixating plates 201 may be a latch, lock, snap, or similar locking mechanism.", "Plate portion 404A is removed from plate 404 and discarded after floss 5 is installed on the fork 204.In the present embodiment, the floss holder allows for effective and convenient flossing thanks to a mechanism for locking and stretching floss 5 on fork 204.This mechanism is located on floss cassette 4 and comprises locking plates 401 and 402 with zigzagged surfaces.", "Referring to FIG.", "4A, locking button 1 and locking plates 401 and 402 are shown in an unlocked position.", "Once housing 2 is closed and floss 5 is placed on fork 204, pushing down locking button 1 causes floss 5 to be locked between locking plates 401 and 402, and sliding locking button 1 towards fork 204 causes a horizontal element 102 of locking button 1 to push down upon a stretching mechanism 403 of floss cassette 4, which results in stretching mechanism 403 being pushed down onto and stretching floss 5 on fork 204 of housing 2.After it is pushed down and slid forward towards the fork 204, locking button 1 holds its position and holds plate 401 in place against plate 402 with the help of protrusions 101 located on locking button 1, which engage with protruding elements 206 on the inside of housing 2.This double locking mechanism provides effecting locking of floss 5 between plates 401 and 402 of floss cassette 4 and stretching of floss 5 on fork 204 by virtue of horizontal element 102 pressing upon stretching mechanism 403.In alternate embodiments, the locking mechanism may be actuated by various different means other than a sliding button such as, but not limited to, a push button, a lever, a dial, etc.", "In the present embodiment to unlock floss 5, locking button 1 is slid away from fork 204 and slides off of protruding elements 206.This releases locking button 1 upward away from plates 401 and 402 and therefore enables plate 401 to move upward, away from plate 402.Plates 410 on the top portion of cassette 4 are shown in FIGS.", "2A, 4A and 4B, towards the rear part of plate 401.Plates 410 facilitate the unlocking of locking plates 401 and 402.Initially plate 401 is located above the plate 402 with a space between the plates 401 and 402 which is needed for smooth removal of the used portion of the floss.", "Plates 401 and 402 preferably have zigzagged surfaces, meaning that the surfaces have ridges (the plates 401 and 402 are toothed if viewed in a cross-section).", "That means that there must be a sufficient gap between the teeth on the substantially horizontal surfaces of the plates 401 and 402 in the unlocked position in order to smoothly remove the used portion of the floss, and to feed the fresh portion to the fork 204.In the process of locking, elements 410 bend and provide locking of the floss between the plates.", "After unlocking, elements 410 return plate 401 to its previous position allowing space to be created for removal of the used portion of the floss.", "A number of housing protrusions 208 located in the housing 2 and preferably at the base 9 of the fork 204 as well (end of the fork 204 opposite to the fork prongs 8), as illustrated in FIG.", "4B, reduces friction of floss 5 while floss 5 slides through the floss holder in order to replace used floss with clean floss.", "Alternate embodiments may be implemented without these protrusions.", "In the present embodiment, a blade 3, which may be rounded, is used for cutting off used floss and is located on the lower portion of housing 2 on a blade plate 205.As shown in FIG.", "1A, this location of blade 3 enables blade 3 to be recessed from the bottom surface of housing 2 for the user's safety while leaving a sufficient length of floss outside housing 2 for easy grasping.", "However, the cutting blade 3 may be located in various different locations in alternate embodiments such as, but not limited to, near the opening from which the floss exits the floss holder, and other alternate embodiments may be implemented without a blade.", "In the present embodiment, the fork 204, which is formed when the two parts of the housing 2 are in the closed position, includes extensions 209 that form a hollow shape which allows for the installation of floss 5 on the fork 204 and holds floss 5 in place during flossing.", "In other words, there is a small space between the extensions 209 to accommodate floss if it needs to be reapplied to the fork (in cases of tears or slipping off), but the positioning of the extensions 209 should allow them to retain the floss on the fork 204 during aggressive use (inserting or removing the floss, and the process of flossing itself).", "The rounded shape of ends 210 of fork 204 facilitates smooth sliding of floss 5 and generally prevents twisting or breaking during use.", "Those skilled in the art will readily recognize, in accordance with the teachings of the present invention that the forks in alternate embodiments may vary in shape.", "For example, without limitation, the prongs 8 of the fork may comprise apertures into which the floss is threaded, or the prongs 8 may comprise shallow grooves into which the floss is placed.", "In some embodiments the prongs 8 of the fork 204 may be made of rubber or may be covered by rubber tips to protect the mouth of the user and to more securely grip the floss.", "In typical use of the present embodiment, which is illustrated by way of example in FIGS.", "IA through 4B, a user opens housing 2 of the floss holder along seam 213 and inserts a loaded floss cassette 4 into housing 2, as shown by way of example in FIG.", "4A.", "Then, the user installs locking button 1 above locking plates 401 and 402 and closes housing 2 by locking fixating plates 201.The user then pulls floss 5 wrapped around plate 404 and plate portion 404A from the floss holder and inserts floss 5 between extensions 209 on fork 204.Once floss 5 is installed on fork 204, the user may break off plate portion 404A.", "To tighten and lock floss 5 in place, the user then slides locking button 1 toward fork 204.The user may now hold the floss holder in either hand to use the portion of floss 5 in fork 204 to floss his teeth.", "In order to replace the used portion of floss 5 with an unused portion, the user slides locking button 1 away from fork 204 to unlock locking plates 401 and 402 and pulls on free end 5A to slide floss 5 through the floss holder and out opening 207.Once the used portion of floss 5 is pulled out of fork 204, the user slides locking button 1 back toward fork 204 to lock the clean portion of floss 5 in place.", "If desired, the user may then take free end 5A of floss 5 up through channel 215 to cut off the excess floss with blade 3.Those skilled in the art will readily recognize, in accordance with the teachings of the present invention, that any of the foregoing steps may be suitably replaced, reordered, removed and additional steps may be inserted depending upon the needs of the particular application.", "For example, without limitation, locking button 1 may be installed before floss cassette 4, and the user may skip the step of cutting the excess floss from free end 5A.", "An alternate embodiment of the present invention may provide a floss holder that does not use a floss cassette.", "In this embodiment, the locking mechanism is built into the housing of the floss holder along with floss holding means.", "A user installs the floss directly into the housing and feeds the floss through the built in locking mechanism prior to use.", "Those skilled in the art will readily recognize, in accordance with the teachings of the present invention, that various features of the floss holder illustrated by way of example in the foregoing may vary in alternate embodiments.", "For example, without limitation, the forks in alternate embodiments may have various different shapes such as, but not limited to, square forks, the housings may have various different shapes including, but not limited to, housings with finger grooves for improved grip or rectangular housings, floss holders in alternate embodiments may come in various different sizes for example, without limitation, adult and children's sizes, etc.", "Furthermore, there are various protrusions illustrated in the foregoing embodiment for guiding the floss and reducing friction.", "In alternate embodiments the number and locations of these protrusions may vary greatly, and some embodiments may be implemented without these protrusions.", "Yet other alternate embodiments may comprise additional features such as, but not limited to, a dental pick, a tongue scraper, an electric motor to provide vibration, etc.", "Having fully described at least one embodiment of the present invention, other equivalent or alternative methods of providing a floss holder according to the present invention will be apparent to those skilled in the art.", "The invention has been described above by way of illustration, and the specific embodiments disclosed are not intended to limit the invention to the particular forms disclosed.", "For example, the particular implementation of the floss cassette may vary depending upon the particular type of floss used.", "The floss spools described in the foregoing were directed to relatively short implementations; however, similar techniques are to provide floss cassettes to accommodate floss spools of various different sizes such as, but not limited to, tall spools or wide spools.", "In some of these implementations, the configuration of the floss within the cassette may vary depending on the size of the spool in order to fit the floss within the floss holder; for example, without limitation, the spool may be held in the cassette vertically rather than horizontally.", "Implementations of the present invention for use with different sizes of floss spools are contemplated as within the scope of the present invention.", "The invention is thus to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the following claims.", "The above description is provided to enable any person skilled in the art to make or use the invention.", "Various modifications to these embodiments will be readily apparent to those skilled in the art, and the principles described herein can be applied to other embodiments without departing from the spirit or scope of the invention and the subject matter of the present invention, which is broadly contemplated by the Applicant.", "The scope of the present invention fully encompasses other embodiments that may be or become obvious to those skilled in the art.", "Claim elements and steps herein may have been numbered and/or lettered solely as an aid in readability and understanding.", "Any such numbering and lettering in itself is not intended to and should not be taken to indicate the ordering of elements and/or steps in the claims." ] ]
Patent_15876126
[ [ "UNA OLIGOMERS AND COMPOSITIONS FOR TREATING AMYLOIDOSIS", "This invention encompasses compounds and compositions useful in methods for medical therapy, in general, for inhibiting expression of a TTR gene in a subject.", "The compounds have a first strand and a second strand, the monomers comprising UNA monomers and nucleic acid monomers, and the compounds are targeted to a sequence of a TTR gene." ], [ "1.A compound comprising a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers comprising UNA monomers and nucleic acid monomers, wherein the compound has a duplex region of from 14 to 29 contiguous monomers in length, wherein the first strand is a passenger strand for RNA interference and the second strand is a guide strand for RNA interference, and wherein the compound comprises a sequence of bases targeted to inhibit expression of a TTR gene.", "2.The compound of claim 1, wherein the compound contains one to seven UNA monomers.", "3.The compound of claim 1, wherein the compound contains a UNA monomer at the 1-end (5′ end for non-UNA) of the first strand, a UNA monomer at the second position from the 3′ end of the first strand, and a UNA monomer at the second position from the 3′ end of the second strand.", "4.The compound of claim 1, wherein the compound contains a UNA monomer at any one or more of positions 2 to 8 from the 5′ end of the second strand.", "5.The compound of claim 1, wherein the compound comprises SEQ ID NOs:60/100, SEQ ID NOs:59/99, SEQ ID NOs:43/83, or SEQ ID NOs:61/101.6.The compound of claim 1, wherein the compound has a 3′ overhang comprising one or more UNA monomers, natural nucleotides, non-natural nucleotides, modified nucleotides, or chemically-modified nucleotides, or combinations thereof.", "7.The compound of claim 1, wherein one or more of the nucleic acid monomers is a non-natural nucleotide, a modified nucleotide, or a chemically-modified nucleotide.", "8.The compound of claim 1, wherein one or more of the nucleic acid monomers has a 2′-O-methyl group.", "9.The compound of claim 1, wherein one or more of three monomers at each end of each strand is connected by a phosphorothioate, a chiral phosphorothioate, or a phosphorodithioate linkage.", "10.A lipid nanoparticle-oligomer compound comprising one or more compounds of claim 1 attached to the lipid nanoparticle.", "11.A composition comprising one or more compounds of claim 1 and a pharmaceutically acceptable carrier.", "12.The composition of claim 11, wherein the carrier comprises lipid nanoparticles or liposomes.", "13.The composition of claim 11, wherein the carrier is a lipid formulation comprising any one or more of the compounds ATX-001 to ATX-032.14.The composition of claim 11, wherein upon administering a single intravenous dose to a subject, the composition reduces TTR protein in the subject by at least 50% after 30 days.", "15.A method for treating or preventing TTR-related amyloidosis in a subject in need, the method comprising administering to the subject an effective amount of a composition of claim 11 to the subject.", "16.The method of claim 15, wherein the TTR-related amyloidosis is ATTR.", "17.The method of claim 15, wherein the administering is intravenous, subcutaneous, pulmonary, intramuscular, intraperitoneal, or dermal.", "18.The method of claim 15, wherein the effective amount is a dose of from 0.001 to 10.0 mg/kg.", "19.The method of claim 15, wherein upon administering a single dose to the subject, the composition reduces TTR protein in the subject by at least 50% after 30 days.", "20.A method for inhibiting expression of a TTR gene in a subject, the method comprising administering to the subject a composition of claim 11." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>The presence of certain diseases appears to correlate with expression of a mutant allele.", "For example, amyloidosis can be correlated to certain transthyretin (TTR) mutations.", "In such cases, it is desirable to selectively silence expression of the mutant allele, while maintaining expression of the wild-type variant.", "Amyloidosis related to transthyretin (ATTR) involves the depositing of amyloid fibril proteins in various organs and tissues, including the peripheral, autonomic, and central nervous systems.", "Transthyretin (TTR) is a secreted thyroid hormone-binding protein that binds and transports retinol binding protein, and serum thyroxine in plasma and cerebrospinal fluid.", "The pathology of ATTR may include many TTR mutations.", "Symptoms of ATTR often include neuropathy and/or cardiomyopathy.", "Peripheral neuropathy can begin in the lower extremities, with sensory and motor neuropathy, and can progress to the upper extremities.", "Autonomic neuropathy can be manifest by gastrointestinal symptoms and orthostatic hypotension.", "Patients with TTR gene Val-30-Met, the most common mutation, have normal echocardiograms.", "However, they may have conduction system irregularities and need a pacemaker.", "The ATTR V30M variant can cause lower extremity weakness, pain, and impaired sensation, as well as autonomic dysfunction.", "Vitreous and opaque amyloid deposits can be characteristic of ATTR.", "Survival upon onset of ATTR may be from five to fifteen years.", "The major treatment for ATTR amyloidosis is liver transplantation, which removes the major source of variant TTR production and replaces it with normal TTR.", "Liver transplantation slows disease progression and some improvement in autonomic and peripheral neuropathy can occur.", "There is currently no pharmacological therapy that can undo the formation of TTR amyloid.", "There is a continuing need for therapeutics for ATTR and other amyloid-related diseases.", "There is a long-standing need for gene silencing agents that can selectively downregulate a disease-related allele.", "There is also a need for active agents that can provide efficient and specific knockdown of TTR." ], [ "<SOH> BRIEF SUMMARY <EOH>This invention relates to the fields of biopharmaceuticals and therapeutics that are operable by gene silencing.", "More particularly, this invention relates to the structures, compositions and uses of active agents for inhibiting expression of a TTR gene in a subject.", "The active agents are UNA oligomers that can be used for gene silencing, and among other things, in methods for treating transthyretin-related amyloidosis.", "This invention relates to the fields of biopharmaceuticals and therapeutics based on allele selective gene silencing.", "More particularly, this invention relates to methods for treating transthyretin-related amyloidosis with UNA oligomers capable of allele-selective knockdown of transthyretin.", "This invention provides UNA oligomers for selectively inhibiting V30M TTR expression, which can be used in treating amyloidosis.", "The UNA oligomers can have a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers being UNA monomers and nucleic acid monomers.", "Embodiments include pharmaceutical compositions and methods for treating or preventing TTR-related amyloidosis by administering a UNA oligomer to a subject.", "Embodiments of this invention include the following: A UNA oligomer for selectively inhibiting V30M TTR expression, the oligomer comprising a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers comprising UNA monomers and nucleic acid monomers, wherein the oligomer has a duplex structure of from 14 to 29 monomers in length.", "The UNA oligomer above, wherein the second strand has at least one UNA monomer in the duplex region.", "The UNA oligomer above, wherein the at least one UNA monomer in the second strand is at any one of positions 2-8 from the 5′ end.", "The UNA oligomer above, wherein the at least one UNA monomer in the second strand is at any one of positions 9-18 from the 5′ end.", "The UNA oligomer above, wherein the at least one UNA monomer in the second strand is at position 6, 7, 15, 16 or 17 from the 5′ end.", "The UNA oligomer above, wherein the oligomer has an IC50 for reducing V30M TTR expression of less than 20 pM.", "The UNA oligomer above, wherein the oligomer has a selectivity ratio of at least 10, wherein the selectivity ratio is the ratio of the IC50 for reducing wild type TTR expression to the IC50 for reducing V30M TTR expression.", "The UNA oligomer above, wherein the oligomer has a selectivity ratio of at least 20.The UNA oligomer above, wherein the oligomer has a selectivity ratio in vitro of at least 50.The UNA oligomer above, wherein the oligomer selectively inhibits V30M TTR expression in vivo.", "The UNA oligomer above, wherein the oligomer selectively inhibits V30M TTR expression ex vivo.", "The UNA oligomer above, comprising at least one nucleic acid monomer that is base-modified, sugar-modified, or linkage modified.", "A compound comprising a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers comprising UNA monomers and nucleic acid monomers, wherein the compound has a duplex region of from 14 to 29 contiguous monomers in length, wherein the first strand is a passenger strand for RNA interference and the second strand is a guide strand for RNA interference, and wherein the compound comprises a sequence of bases targeted to inhibit expression of a TTR gene.", "In some embodiments, the compound may contain from one to seven UNA monomers.", "In certain embodiments, the compound may contain a UNA monomer at the 1-end (5′ end for non-UNA) of the first strand, a UNA monomer at the second position from the 3′ end of the first strand, and a UNA monomer at the second position from the 3′ end of the second strand.", "In further embodiments, the compound may contain a UNA monomer at any one or more of positions 2 to 8 from the 5′ end of the second strand.", "In additional embodiments, the compound may have a 3′ overhang comprising one or more UNA monomers, natural nucleotides, non-natural nucleotides, modified nucleotides, or chemically-modified nucleotides, or combinations thereof.", "The compound may have a 3′ overhang comprising one or more deoxythymidine nucleotides, 2′-O-methyl nucleotides, inverted abasic monomers, inverted thymidine monomers, L-thymidine monomers, or glyceryl nucleotides.", "Embodiments of this invention contemplate compounds in which one or more of the nucleic acid monomers may be a non-natural nucleotide, a modified nucleotide, or a chemically-modified nucleotide.", "A nucleic acid monomer may have a 2′-O-methyl group, a 2′-methoxyethoxy, or a 2′-deoxy-2′-fluoro ribonucleotide.", "In some embodiments, the compound may not contain fluorine.", "A compound may have one or more of three monomers at each end of each strand being connected by a phosphorothioate, a chiral phosphorothioate, or a phosphorodithioate linkage.", "This invention further contemplates a lipid nanoparticle-oligomer compound comprising one or more compounds above attached to the lipid nanoparticle, as well as compositions containing one or more compounds above and a pharmaceutically acceptable carrier.", "In certain embodiments, the carrier may include lipid nanoparticles or liposomes.", "A composition of this disclosure, upon administering a single intravenous dose to a subject, may reduce TTR protein in the subject by at least 80% after 10 days, or at least 70% after 20 days, or at least 50% after 30 days.", "Embodiments of this invention further include methods for treating or preventing TTR-related amyloidosis in a subject in need, by administering to the subject an effective amount of a composition above to the subject.", "The TTR-related amyloidosis can be ATTR.", "The administering can be intravenous, subcutaneous, pulmonary, intramuscular, intraperitoneal, or dermal.", "The effective amount can be a dose of from 0.001 to 10.0 mg/kg.", "In some embodiments, upon administering a single dose to a subject, the composition may reduce TTR protein in the subject by at least 70% after 20 days, or by at least 50% after 30 days.", "This invention includes methods for inhibiting expression of a TTR gene in a subject, by administering to the subject a composition above.", "Further aspects include the use of a composition above for preventing, ameliorating or treating a disease or condition associated with TTR-related amyloidosis in a subject in need, or for use in medical therapy, or for use in the treatment of the human or animal body.", "This invention further includes compositions above for use in preparing or manufacturing a medicament for preventing, ameliorating or treating a disease or condition associated with TTR-related amyloidosis in a subject in need." ], [ "REFERENCE TO THE SEQUENCE LISTING This application includes a Sequence Listing submitted electronically as an ASCII file created on Jan. 20, 2018, named ARC1242US_SL.txt, which is 37,860 bytes in size, and is hereby incorporated by reference in its entirety.", "BACKGROUND OF THE INVENTION The presence of certain diseases appears to correlate with expression of a mutant allele.", "For example, amyloidosis can be correlated to certain transthyretin (TTR) mutations.", "In such cases, it is desirable to selectively silence expression of the mutant allele, while maintaining expression of the wild-type variant.", "Amyloidosis related to transthyretin (ATTR) involves the depositing of amyloid fibril proteins in various organs and tissues, including the peripheral, autonomic, and central nervous systems.", "Transthyretin (TTR) is a secreted thyroid hormone-binding protein that binds and transports retinol binding protein, and serum thyroxine in plasma and cerebrospinal fluid.", "The pathology of ATTR may include many TTR mutations.", "Symptoms of ATTR often include neuropathy and/or cardiomyopathy.", "Peripheral neuropathy can begin in the lower extremities, with sensory and motor neuropathy, and can progress to the upper extremities.", "Autonomic neuropathy can be manifest by gastrointestinal symptoms and orthostatic hypotension.", "Patients with TTR gene Val-30-Met, the most common mutation, have normal echocardiograms.", "However, they may have conduction system irregularities and need a pacemaker.", "The ATTR V30M variant can cause lower extremity weakness, pain, and impaired sensation, as well as autonomic dysfunction.", "Vitreous and opaque amyloid deposits can be characteristic of ATTR.", "Survival upon onset of ATTR may be from five to fifteen years.", "The major treatment for ATTR amyloidosis is liver transplantation, which removes the major source of variant TTR production and replaces it with normal TTR.", "Liver transplantation slows disease progression and some improvement in autonomic and peripheral neuropathy can occur.", "There is currently no pharmacological therapy that can undo the formation of TTR amyloid.", "There is a continuing need for therapeutics for ATTR and other amyloid-related diseases.", "There is a long-standing need for gene silencing agents that can selectively downregulate a disease-related allele.", "There is also a need for active agents that can provide efficient and specific knockdown of TTR.", "BRIEF SUMMARY This invention relates to the fields of biopharmaceuticals and therapeutics that are operable by gene silencing.", "More particularly, this invention relates to the structures, compositions and uses of active agents for inhibiting expression of a TTR gene in a subject.", "The active agents are UNA oligomers that can be used for gene silencing, and among other things, in methods for treating transthyretin-related amyloidosis.", "This invention relates to the fields of biopharmaceuticals and therapeutics based on allele selective gene silencing.", "More particularly, this invention relates to methods for treating transthyretin-related amyloidosis with UNA oligomers capable of allele-selective knockdown of transthyretin.", "This invention provides UNA oligomers for selectively inhibiting V30M TTR expression, which can be used in treating amyloidosis.", "The UNA oligomers can have a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers being UNA monomers and nucleic acid monomers.", "Embodiments include pharmaceutical compositions and methods for treating or preventing TTR-related amyloidosis by administering a UNA oligomer to a subject.", "Embodiments of this invention include the following: A UNA oligomer for selectively inhibiting V30M TTR expression, the oligomer comprising a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers comprising UNA monomers and nucleic acid monomers, wherein the oligomer has a duplex structure of from 14 to 29 monomers in length.", "The UNA oligomer above, wherein the second strand has at least one UNA monomer in the duplex region.", "The UNA oligomer above, wherein the at least one UNA monomer in the second strand is at any one of positions 2-8 from the 5′ end.", "The UNA oligomer above, wherein the at least one UNA monomer in the second strand is at any one of positions 9-18 from the 5′ end.", "The UNA oligomer above, wherein the at least one UNA monomer in the second strand is at position 6, 7, 15, 16 or 17 from the 5′ end.", "The UNA oligomer above, wherein the oligomer has an IC50 for reducing V30M TTR expression of less than 20 pM.", "The UNA oligomer above, wherein the oligomer has a selectivity ratio of at least 10, wherein the selectivity ratio is the ratio of the IC50 for reducing wild type TTR expression to the IC50 for reducing V30M TTR expression.", "The UNA oligomer above, wherein the oligomer has a selectivity ratio of at least 20.The UNA oligomer above, wherein the oligomer has a selectivity ratio in vitro of at least 50.The UNA oligomer above, wherein the oligomer selectively inhibits V30M TTR expression in vivo.", "The UNA oligomer above, wherein the oligomer selectively inhibits V30M TTR expression ex vivo.", "The UNA oligomer above, comprising at least one nucleic acid monomer that is base-modified, sugar-modified, or linkage modified.", "A compound comprising a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers comprising UNA monomers and nucleic acid monomers, wherein the compound has a duplex region of from 14 to 29 contiguous monomers in length, wherein the first strand is a passenger strand for RNA interference and the second strand is a guide strand for RNA interference, and wherein the compound comprises a sequence of bases targeted to inhibit expression of a TTR gene.", "In some embodiments, the compound may contain from one to seven UNA monomers.", "In certain embodiments, the compound may contain a UNA monomer at the 1-end (5′ end for non-UNA) of the first strand, a UNA monomer at the second position from the 3′ end of the first strand, and a UNA monomer at the second position from the 3′ end of the second strand.", "In further embodiments, the compound may contain a UNA monomer at any one or more of positions 2 to 8 from the 5′ end of the second strand.", "In additional embodiments, the compound may have a 3′ overhang comprising one or more UNA monomers, natural nucleotides, non-natural nucleotides, modified nucleotides, or chemically-modified nucleotides, or combinations thereof.", "The compound may have a 3′ overhang comprising one or more deoxythymidine nucleotides, 2′-O-methyl nucleotides, inverted abasic monomers, inverted thymidine monomers, L-thymidine monomers, or glyceryl nucleotides.", "Embodiments of this invention contemplate compounds in which one or more of the nucleic acid monomers may be a non-natural nucleotide, a modified nucleotide, or a chemically-modified nucleotide.", "A nucleic acid monomer may have a 2′-O-methyl group, a 2′-methoxyethoxy, or a 2′-deoxy-2′-fluoro ribonucleotide.", "In some embodiments, the compound may not contain fluorine.", "A compound may have one or more of three monomers at each end of each strand being connected by a phosphorothioate, a chiral phosphorothioate, or a phosphorodithioate linkage.", "This invention further contemplates a lipid nanoparticle-oligomer compound comprising one or more compounds above attached to the lipid nanoparticle, as well as compositions containing one or more compounds above and a pharmaceutically acceptable carrier.", "In certain embodiments, the carrier may include lipid nanoparticles or liposomes.", "A composition of this disclosure, upon administering a single intravenous dose to a subject, may reduce TTR protein in the subject by at least 80% after 10 days, or at least 70% after 20 days, or at least 50% after 30 days.", "Embodiments of this invention further include methods for treating or preventing TTR-related amyloidosis in a subject in need, by administering to the subject an effective amount of a composition above to the subject.", "The TTR-related amyloidosis can be ATTR.", "The administering can be intravenous, subcutaneous, pulmonary, intramuscular, intraperitoneal, or dermal.", "The effective amount can be a dose of from 0.001 to 10.0 mg/kg.", "In some embodiments, upon administering a single dose to a subject, the composition may reduce TTR protein in the subject by at least 70% after 20 days, or by at least 50% after 30 days.", "This invention includes methods for inhibiting expression of a TTR gene in a subject, by administering to the subject a composition above.", "Further aspects include the use of a composition above for preventing, ameliorating or treating a disease or condition associated with TTR-related amyloidosis in a subject in need, or for use in medical therapy, or for use in the treatment of the human or animal body.", "This invention further includes compositions above for use in preparing or manufacturing a medicament for preventing, ameliorating or treating a disease or condition associated with TTR-related amyloidosis in a subject in need.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 shows the single nucleotide polymorph (SNP) that exists at position 284 in the V30M mutation mRNA, as compared to the wild type (WT) TTR mRNA.", "Conventional siRNAs that are complementary to the WT mRNA can be tiled around position 284.FIG.", "2 shows that the conventional siRNAs complementary to the WT mRNA have limited activity in silencing the WT TTR gene, as measured by TTR knockdown in HepG2 cells.", "Positions 5, 9, 14 and 15, indicated by arrows, appear to be more accessible to silencing than other positions.", "FIG.", "3 shows that conventional siRNAs that are complementary to the V30M mRNA can be tiled around position 284.Four conventional siRNA variations, namely V30M-P5, V30M-P9, V30M-P14, and V30M-P15, were prepared.", "Also, as shown in FIG.", "3, two reporter variants, V30V and V30M, each bearing nucleotide sequence 264 to 304 of human TTR, V30V being without the point mutation at position 284, and V30M containing the point mutation at position 284, were prepared and used in the PSICHECK reporter system in the 3′-UTR region of Luciferase gene.", "FIG.", "4 shows the activity of the four conventional siRNA variations V30M-P5, V30M-P9, V30M-P14, and V30M-P15 measured in the PSICHECK reporter assay against V30V and V30M gene reporter variants.", "The conventional siRNA variations V30M-P5, V30M-P9, and V30M-P15 were more effective against V30M than V30V.", "The conventional siRNA variation V30M-P14 was not more effective against V30M than V30V.", "FIG.", "5 shows IC50 analysis for the four conventional siRNA variations V30M-P5, V30M-P9, V30M-P14, and V30M-P15 measured in the PSICHECK reporter assay against V30V and V30M gene reporter variants.", "The conventional V30M-P15 variant was 5.6 times more effective against V30M than V30V.", "Thus, the selectivity of the conventional siRNAs against V30M over V30V was no more than 5.6.FIG.", "6 shows the structure of UNA oligomers that were effective in silencing V30M TTR, as measured in the PSICHECK reporter assay.", "Each of the UNA oligomer embodiments, P15U6, P15U7, P15U14, P15U15, and P15U16, contained four UNA monomers.", "In each UNA oligomer, a first UNA monomer was located at the 5′ end of the first strand, also called the passenger strand.", "In each UNA oligomer, the second strand, also called the guide strand, formed a duplex region of 19 monomers length with the first strand.", "Each UNA oligomer had a duplex region of 19 monomers, and a two-monomer overhang at each end.", "In each UNA oligomer, a second UNA monomer was located at the 3′ end of the first strand, in the 20th position, which is in an overhang portion.", "In each UNA oligomer, a third UNA monomer was located at the 3′ end of the second strand, in the 20th position, which is in an overhang portion.", "In the UNA oligomer embodiments, P15U6, P15U7, P15U14, P15U15, and P15U16, a fourth UNA monomer was located in the second strand at positions 6, 7, 14, 15 and 16, respectively, counting from the 5′ end of the second strand.", "FIG.", "7 shows the activity of UNA oligomers P15U6, P15U7, P15U15, and P15U16, measured in the PSICHECK reporter assay against V30V and V30M gene reporter variants, as compared to the conventional siRNA V30M-P15.For each of the UNA oligomer embodiments, P15U6, P15U7, P15U15, and P15U16, the UNA oligomers were more effective against V30M than V30V.", "Surprisingly, the activity of the UNA oligomer P15U6 was substantially and advantageously superior to the activity of the conventional siRNA V30M-P15, where each is targeted to V30M.", "Furthermore, FIG.", "7 shows the surprising and unexpected result that the selectivity of the UNA oligomers, P15U6, P15U7, P15U15, and P15U16, against V30M over V30V was substantially greater than for the conventional siRNA V30M-P15.In particular, the selectivity of UNA oligomer P15U6 against V30M over V30V was 24, meaning that the IC50 of UNA oligomer P15U6 against V30M (37.6 pM) was 24 times lower than the IC50 of UNA oligomer P15U6 against V30V (919.9 pM).", "This selectivity was advantageously 4-fold superior to the selectivity of 5.6 shown above in FIG.", "5 for the conventional siRNA.", "FIG.", "8 shows the structure of UNA oligomers that were effective in silencing V30M TTR, as measured in the PSICHECK reporter assay.", "Each of the UNA oligomer embodiments, P16U6, P16U7, P16U15, P16U16, and P16U17, contained four UNA monomers.", "In each UNA oligomer, a first UNA monomer was located at the 5′ end of the first strand, also called the passenger strand.", "In each UNA oligomer, the second strand, also called the guide strand, formed a duplex region of 19 monomers length with the first strand.", "Each UNA oligomer had a duplex region of 19 monomers, and a two-monomer overhang at each end.", "In each UNA oligomer, a second UNA monomer was located at the 3′ end of the first strand, in the 20th position, which is in an overhang portion.", "In each UNA oligomer, a third UNA monomer was located at the 3′ end of the second strand, in the 20th position, which is in an overhang portion.", "In the UNA oligomer embodiments, P16U6, P16U7, P16U15, P16U16, and P16U17, a fourth UNA monomer was located in the second strand at positions 6, 7, 15, 16 and 17, respectively, counting from the 5′ end of the second strand.", "FIG.", "9 shows the activity of UNA oligomers P16U6, P16U7, P16U15, and P16U16, measured in the PSICHECK reporter assay against V30V and V30M gene reporter variants, as compared to the conventional siRNA V30M-P16.For each of the UNA oligomer embodiments, P16U6, P16U7, P16U15, and P16U16, the UNA oligomers were more effective against V30M than V30V.", "Surprisingly, the activity of each of the UNA oligomers P16U6, P16U7, P16U15, and P16U16, was substantially and advantageously superior to the activity of the conventional siRNA V30M-P16, where each is targeted to V30M.", "Furthermore, FIG.", "9 shows the surprising and unexpected result that the selectivity of the UNA oligomers, P16U6, P16U7, P16U15, and P16U16, against V30M over V30V was substantially greater than for the conventional siRNA V30M-P16.In particular, the selectivity of UNA oligomer P16U6 against V30M over V30V was 23, meaning that the IC50 of UNA oligomer P16U6 against V30M (92.4 pM) was 23 times lower than the IC50 of UNA oligomer P16U6 against V30V (2119 pM).", "This selectivity was advantageously 4-fold superior to the selectivity of 5.6 shown above in FIG.", "5 for the conventional siRNA.", "FIG.", "10 (left) shows the selectivity of UNA oligomer P15U6 against V30M over V30V.", "The IC50 of UNA oligomer P15U6 against V30M (37.6 pM) was 24 times lower than the IC50 of UNA oligomer P15U6 against V30V (919.9 pM).", "This selectivity was advantageously 4-fold superior to the selectivity of 5.6 shown in FIG.", "5 above for the conventional siRNA.", "FIG.", "10 (right) shows the surprising and unexpected result that the IC50 of UNA oligomer P16U6 against V30M (92.4 pM) was 23 times lower than the IC50 of UNA oligomer P16U6 against V30V (2119 pM).", "This selectivity was advantageously 4-fold superior to the selectivity of 5.6 shown above in FIG.", "5 for the conventional siRNA.", "FIG.", "11 shows knockdown of Transthyretin protein in vivo as a result of treatment with UNA oligomers targeting Transthyretin TTR mRNA, delivered in a liposomal formulation to male Cynomolgus monkeys.", "Measurements were made following a single intravenous (IV) dose administration.", "TTR protein concentration in plasma samples was assessed by LC-MS/MS at various time points.", "Animals were administered test doses on Day 1 at 0.3 mg/kg.", "Doses were administered as a 15-minute intravenous (IV) infusion, +1 minute, using a pump and disposable syringe.", "DETAILED DESCRIPTION OF THE INVENTION This invention provides UNA oligomers for selectively inhibiting V30M TTR expression.", "The UNA oligomers of this invention can be used as therapeutics for treating amyloidosis.", "In particular, this invention provides UNA oligomers, compositions and methods for treating transthyretin-related amyloidosis.", "The UNA oligomers can have a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers being UNA monomers and nucleic acid monomers.", "Embodiments of this invention include compositions and methods for treating or preventing TTR-related amyloidosis by administering a UNA oligomer to a subject.", "The UNA oligomers of this invention are capable of allele-specific knockdown of transthyretin.", "In some embodiments, UNA oligomers are provided for treating amyloidosis related to transthyretin (ATTR).", "The UNA oligomers of this invention can reduce the depositing of amyloid fibril proteins in various organs and tissues, including the peripheral, autonomic, and central nervous systems.", "In certain aspects, this invention provides therapeutics for ATTR and related amyloid-related diseases.", "Aspects of this invention include UNA oligomers that can be used for treating clinical features of ATTR amyloidosis, including neuropathy and/or cardiomyopathy.", "In some embodiments, UNA oligomers of this invention are targeted to one mutation Val-30-Met TTR.", "This invention can provide a pharmacological therapy that can undo the formation of TTR amyloid.", "Homo sapiens transthyretin (TTR) mRNA is found at NCBI Reference Sequence: NM_000371.3.In some aspects, a composition of this invention can provide an unexpectedly advantageous duration of action.", "In certain embodiments, upon administering a single dose of a composition containing a UNA oligomer of this invention, the TTR protein in a subject may be reduced by at least 90% after 20 days.", "In further embodiments, upon administering a single dose of a pharmaceutical composition containing a UNA oligomer of this invention, the TTR protein in a subject may be reduced by at least 70% for a period of at least 20 days.", "In additional embodiments, upon administering a single dose of a pharmaceutical composition containing a UNA oligomer of this invention, the TTR protein in a subject may be reduced by at least 50% for a period of at least 30 days.", "A subject can be a primate, a human, or other mammal.", "UNA Oligomers The UNA oligomers of this invention can be used for inhibiting V30M TTR expression.", "A UNA oligomer of this invention the oligomer may have a first strand and a second strand, each of the strands being 19-29 monomers in length.", "The monomers of a UNA oligomer can include UNA monomers and nucleic acid monomers A UNA oligomer can be a duplex structure of from 14 to 29 monomers in length.", "In some embodiments, the second strand of a UNA oligomer can have at least one UNA monomer in the duplex region.", "In certain embodiments, a UNA oligomer can have at least one UNA monomer in the second strand at any of positions 6, 7, 15, 16 or 17 from the 5′ end in the duplex region.", "A UNA oligomer of this invention may have any number of UNA monomers within its total length.", "A UNA oligomer can include a nucleic acid monomer that is base-modified, sugar-modified, or linkage modified.", "Embodiments of this invention further provide UNA oligomers that selectively inhibit V30M TTR expression.", "In certain embodiments, a UNA oligomer has an IC50 for reducing V30M TTR expression in vitro of less than 20 pM.", "In further embodiments, a UNA oligomer can have a selectivity ratio in vitro of at least 5.The selectivity ratio is the ratio of the IC50 for reducing V30M TTR expression to the IC50 for reducing wild type TTR expression.", "The selectivity ratio of a UNA oligomer of this invention can range from 2 to 1000.In certain embodiments, the selectivity ratio of a UNA oligomer is at least 2, or at least 5, or at least 10, or at least 30, or at least 30, or at least 50, or at least 100.In some aspects, a UNA oligomer of this invention can selectively inhibit V30M TTR expression in vivo.", "In certain aspects, a UNA oligomer of this invention can selectively inhibit V30M TTR expression ex vivo.", "A UNA oligomer can be an active pharmaceutical molecule being a chain composed of monomers, also called an oligomer.", "The monomers of the oligomer can include UNA monomers and other nucleic acid monomers.", "The UNA monomers are novel, synthetic molecules that can be attached in a chain to form an oligomer.", "The nucleic acid monomers can be naturally-occurring nucleotides, modified naturally-occurring nucleotides, or certain non-naturally-occurring nucleotides.", "A UNA oligomer of this invention is a synthetic, pharmacologically active molecule and can be used in the treatment of a condition or disease.", "A UNA oligomer of this disclosure can be a double stranded oligomer.", "Each strand of the double stranded oligomer can be composed of UNA monomers along with a number of nucleic acid monomers for a total length of 19 to 29 monomers.", "A UNA oligomer of this invention can contain one or more UNA monomers in any strand.", "The UNA monomers can be in a single strand, or in either strand of a double stranded UNA oligomer, or in both strands of a double stranded UNA oligomer.", "UNA Monomers In some embodiments, linker group monomers can be unlocked nucleomonomers (UNA monomers), which are small organic molecules based on a propane-1,2,3-tri-yl-trisoxy structure as shown below: where R1 and R2 are H, and R1 and R2 can be phosphodiester linkages, Base can be a nucleobase, and R3 is a functional group described below.", "In another view, the UNA monomer main atoms can be drawn in IUPAC notation as follows: where the direction of progress of the oligomer chain is from the 1-end to the 3-end of the propane residue.", "Examples of a nucleobase include uracil, thymine, cytosine, 5-methylcytosine, adenine, guanine, inosine, and natural and non-natural nucleobase analogues.", "In general, because the UNA monomers are not nucleotides, they can exhibit at least four forms in an oligomer.", "First, a UNA monomer can be an internal monomer in an oligomer, where the UNA monomer is flanked by other monomers on both sides.", "In this form, the UNA monomer can participate in base pairing when the oligomer is a duplex, for example, and there are other monomers with nucleobases in the duplex.", "Examples of UNA monomer as internal monomers flanked at both the propane-1-yl position and the propane-3-yl position, where R3 is —OH, are shown below.", "Second, a UNA monomer can be a monomer in an overhang of an oligomer duplex, where the UNA monomer is flanked by other monomers on both sides.", "In this form, the UNA monomer does not participate in base pairing.", "Because the UNA monomers are flexible organic structures, unlike nucleotides, the overhang containing a UNA monomer will be a flexible terminator for the oligomer.", "A UNA monomer can be a terminal monomer in an overhang of an oligomer, where the UNA monomer is attached to only one monomer at either the propane-1-yl position or the propane-3-yl position.", "In this form, the UNA monomer does not participate in base pairing.", "Because the UNA monomers are flexible organic structures, unlike nucleotides, the overhang containing a UNA monomer can be a flexible terminator for the oligomer.", "Examples of a UNA monomer as a terminal monomer attached at the propane-3-yl position are shown below.", "Because a UNA monomer can be a flexible molecule, a UNA monomer as a terminal monomer can assume widely differing conformations.", "An example of an energy minimized UNA monomer conformation as a terminal monomer attached at the propane-3-yl position is shown below.", "Thus, UNA oligomers having a terminal UNA monomer are significantly different in structure from conventional nucleic acid agents, such as siRNAs.", "For example, siRNAs may require that terminal monomers or overhangs in a duplex be stabilized.", "In contrast, the conformability of a terminal UNA monomer can provide UNA oligomers with different properties.", "Among other things, the structure of the UNA monomer allows it to be attached to naturally-occurring nucleotides.", "A UNA oligomer can be a chain composed of UNA monomers, as well as various nucleotides that may be based on naturally-occurring nucleosides.", "In some embodiments, the functional group R3 of a UNA monomer can be —OR4, —SR4, —NR42, —NH(C═O)R4, morpholino, morpholin-1-yl, piperazin-1-yl, or 4-alkanoyl-piperazin-1-yl, where R4 is the same or different for each occurrence, and can be H, alkyl, a cholesterol, a lipid molecule, a polyamine, an amino acid, or a polypeptide.", "The UNA monomers are organic molecules.", "UNA monomers are not nucleic acid monomers or nucleotides, nor are they naturally-occurring nucleosides or modified naturally-occurring nucleosides.", "A UNA oligomer of this invention is a synthetic chain molecule.", "A UNA oligomer of this invention is not a nucleic acid, nor an oligonucleotide.", "In some embodiments, as shown above, a UNA monomer can be UNA-A (designated Ã), UNA-U (designated Ũ), UNA-C (designated Č), and UNA-G (designated Ğ).", "Designations that may be used herein include mA, mG, mC, and mU, which refer to the 2′-O-Methyl modified ribonucleotides.", "Designations that may be used herein include lower case c and u, which refer to the 2′-O-methyl modified ribonucleotides.", "Designations that may be used herein include dT, which refers to a 2′-deoxy T nucleotide.", "Monomers for UNA Oligomers As used herein, in the context of oligomer sequences, the symbol X represents a UNA monomer.", "As used herein, in the context of oligomer sequences, the symbol N represents any natural nucleotide monomer, or a modified nucleotide monomer.", "As used herein, in the context of oligomer sequences, the symbol Q represents a non-natural, modified, or chemically-modified nucleotide monomer.", "When a Q monomer appears in one strand of the oligomer, and is unpaired with the other strand, the monomer can have any base attached.", "When a Q monomer appears in one strand of the oligomer, and is paired with a monomer in the other strand, the Q monomer can have any base attached that would be complementary to the monomer in the corresponding paired position in the other strand.", "Examples of nucleic acid monomers include non-natural, modified, and chemically-modified nucleotides, including any such nucleotides known in the art.", "Examples of non-natural, modified, and chemically-modified nucleotide monomers include 2′-O-methyl ribonucleotides, 2′-O-methyl purine nucleotides, 2′-deoxy-2′-fluoro ribonucleotides, 2′-deoxy-2′-fluoro pyrimidine nucleotides, 2′-deoxy ribonucleotides, 2′-deoxy purine nucleotides, universal base nucleotides, 5-C-methyl-nucleotides, and inverted deoxyabasic monomer residues.", "Examples of non-natural, modified, and chemically-modified nucleotide monomers include 3′-end stabilized nucleotides, 3′-glyceryl nucleotides, 3′-inverted abasic nucleotides, and 3′-inverted thymidine, and L-thymidine.", "Examples of non-natural, modified, and chemically-modified nucleotide monomers include locked nucleic acid nucleotides, 2′-O,4′-C-methylene-(D-ribofuranosyl) nucleotides, 2′-methoxyethoxy (MOE) nucleotides, 2′-methyl-thio-ethyl, 2′-deoxy-2′-fluoro nucleotides, and 2′-O-methyl nucleotides.", "Examples of non-natural, modified, and chemically-modified nucleotide monomers include 2′-amino nucleotides, 2′-O-amino nucleotides, 2′-C-allyl nucleotides, and 2′-O-allyl nucleotides.", "Examples of non-natural, modified, and chemically-modified nucleotide monomers include N6-methyladenosine nucleotides.", "Examples of non-natural, modified, and chemically-modified nucleotide monomers include nucleotide monomers with modified bases 5-(3-amino)propyluridine, 5-(2-mercapto)ethyluridine, 5-bromouridine; 8-bromoguanosine, or 7-deazaadenosine.", "Examples of non-natural, modified, and chemically-modified nucleotide monomers include 2′-O-aminopropyl substituted nucleotides.", "Examples of non-natural, modified, and chemically-modified nucleotide monomers include 2′-O-guanidinopropyl substituted nucleotides.", "Examples of non-natural, modified, and chemically-modified nucleotide monomers include Pseudouridines.", "Examples of non-natural, modified, and chemically-modified nucleotide monomers include replacing the 2′-OH group of a nucleotide with a 2′-R, a 2′-OR, a 2′-halogen, a 2′-SR, or a 2′-amino, or a 2′-azido, where R can be H, alkyl, fluorine-substituted alkyl, alkenyl, or alkynyl.", "Examples of non-natural, modified, and chemically-modified nucleotide monomers include replacing the 2′—OH group of a nucleotide with a 2′-R or 2′-OR, where R can be CN, CF3, alkylamino, or aralkyl.", "Examples of non-natural, modified, and chemically-modified nucleotide monomers include nucleotides with a modified sugar such as an F-HNA, an HNA, a CeNA, a bicyclic sugar, or an LNA.", "Examples of non-natural, modified, and chemically-modified nucleotide monomers include 2′-oxa-3′-aza-4′a-carbanucleoside monomers, 3-hydroxymethyl-5-(1H-1,2,3-triazol)-isoxazolidine monomers, and 5′-triazolyl-2′-oxa-3′-aza-4′a-carbanucleoside monomers.", "Some examples of modified nucleotides are given in Saenger, Principles of Nucleic Acid Structure, Springer-Verlag, 1984.Details of UNA Oligomer Structure Aspects of this invention can provide structures and compositions for UNA-containing oligomeric compounds.", "The oligomeric agents may incorporate one or more UNA monomers.", "Oligomeric molecules of this invention can be used as active agents in formulations for gene regulating or gene silencing therapeutics.", "In some embodiments, this invention provides oligomeric compounds having a structure that incorporates novel combinations of UNA monomers with certain natural nucleotides, non-natural nucleotides, modified nucleotides, or chemically-modified nucleotides.", "In further aspects, the oligomeric compounds can be pharmacologically active molecules.", "UNA oligomers of this invention can be used as active pharmaceutical ingredients for regulating gene expression, and in RNA interference methods, as well as antisense, RNA blocking, and micro-RNA strategies.", "A UNA oligomer of this invention can have the structure of Formula I wherein L1 is a linkage, n is from 19 to 29, and for each occurrence L2 is a UNA linker group having the formula —C1—C2—C3—, where R is attached to C2 and has the formula —OCH(CH2R3)R5, where R3 is —OR4, —SR4, —NR42, —NH(C═O)R4, morpholino, morpholin-1-yl, piperazin-1-yl, or 4-alkanoyl-piperazin-1-yl, where R4 is the same or different for each occurrence and is H, alkyl, a cholesterol, a lipid molecule, a polyamine, an amino acid, or a polypeptide, and where R5 is a nucleobase, or L2(R) is a sugar such as a ribose and R is a nucleobase, or L2 is a modified sugar such as a modified ribose and R is a nucleobase.", "In certain embodiments, a nucleobase can be a modified nucleobase.", "L1 can be a phosphodiester linkage.", "A UNA oligomer of this invention can be a short chain molecule.", "A UNA oligomer can be a duplex pair.", "Thus, a UNA oligomer can have a first strand of the duplex and a second strand of the duplex, which is complementary to the first strand with respect to the nucleobases, although up to three mismatches can occur.", "A UNA oligomer duplex can have overhangs.", "Some UNA oligomers are discussed in U.S. Pat.", "No.", "8,314,227, as well as US Patent Publication No.", "20110313020 A1.The target of a UNA oligomer can be a target nucleic acid.", "In some embodiments, the target can be any TTR mRNA of a subject.", "A UNA oligomer can be active for gene silencing in RNA interference.", "A UNA oligomer may comprise two strands that together provide a duplex.", "The duplex may be composed of a first strand, which may also be referred to as a passenger strand or sense strand, and a second strand, which may also be referred to as a guide strand or antisense strand.", "In some aspects, a UNA oligomer of this invention can have any number of phosphorothioate intermonomer linkages in any position in any strand, or in both strands of a duplex structure.", "In certain embodiments, a UNA oligomer of this invention can have a phosphorothioate intermonomer linkage between the last one or two monomers at either end of any strand.", "In some embodiments, any one or more of the intermonomer linkages of a UNA oligomer can be a phosphodiester, a phosphorothioate including dithioates, a chiral phosphorothioate, and other chemically modified forms.", "Examples of UNA oligomers of this invention include duplex pairs, which are in general complementary.", "Thus, for example, SEQ ID NO: 1 can represent a first strand of a duplex and SEQ ID NO:2 can represent a second strand of the duplex, which is complementary to the first strand.", "For example, the symbol “N” in the first strand can represent any nucleotide that is complementary to the monomer in the corresponding position in the second strand.", "Example UNA oligomers of this disclosure are shown with 2-monomer length overhangs, although overhangs of from 1 to 8 monomers, or longer, can be used.", "The symbol “X” in a strand or oligomer represents a UNA monomer.", "When a UNA monomer appears in one strand of the oligomer, and is unpaired with the other strand, the monomer can have any base attached.", "When a UNA monomer appears in one strand of the oligomer, and is paired with a monomer in the other strand, the UNA monomer can have any base attached that would be complementary to the monomer in the corresponding paired position in the other strand.", "Further, when the oligomer terminates in a UNA monomer, the terminal position has a 1-end, according to the positional numbering shown above, instead of a 5′-end as for a nucleotide, or the terminal position has a 3-end, according to the positional numbering shown above, instead of a 3′-end as for a nucleotide.", "For example, the UNA oligomer SEQ ID NO: 1 1-X•N•N•N•N•N•N•N•N•N•N•N•N•N•N•N•N•N•N•N•X•X-3 3-X•X•N•N•N•N•N•N•N•N•N•N•N•X•X•X•X•X•X•X•N-5′ SEQ ID NO: 2 has a UNA monomer 1-end on the first strand, a UNA monomer 3-end on the first strand, a UNA monomer 3-end on the second strand, and a nucleotide 5′-end on the second strand.", "Complementarity of strands can involve mismatches.", "In certain embodiments, complementarity of strands can include one to three, or more, mismatches.", "In some embodiments, a UNA oligomer of this invention can have one or more UNA monomers at the 1-end of the first strand, and one or more UNA monomers at the 3-end of the first strand.", "In further embodiments, a UNA oligomer of this invention can have one or more UNA monomers at the 3-end of the second strand.", "In certain embodiments, a duplex UNA oligomer of this invention can have one or more UNA monomers at the 1-end of the first strand, one or more UNA monomers at the 3-end of the first strand, and one or more UNA monomers at the 3-end of the second strand.", "A UNA oligomer of this invention the oligomer may have a first strand and a second strand, each of the strands independently being 19-23 monomers in length.", "In certain embodiments, a UNA oligomer of this invention may have a first strand that is 19-23 monomers in length.", "In certain embodiments, a UNA oligomer of this invention may have a duplex region that is 19-21 monomers in length.", "In further embodiments, a UNA oligomer of this invention may have a second strand that is 19-23 monomers in length.", "In certain embodiments, a UNA oligomer of this invention may have a first strand that is 19 monomers in length, and a second strand that is 21 monomers in length.", "In certain embodiments, a UNA oligomer of this invention may have a first strand that is 20 monomers in length, and a second strand that is 21 monomers in length.", "In certain embodiments, a UNA oligomer of this invention may have a first strand that is 21 monomers in length, and a second strand that is 21 monomers in length.", "In certain embodiments, a UNA oligomer of this invention may have a first strand that is 22 monomers in length, and a second strand that is 21 monomers in length.", "A UNA oligomer of this invention for inhibiting gene expression can have a first strand and a second strand, each of the strands being 19-29 monomers in length.", "The monomers can be UNA monomers and nucleic acid nucleoside monomers.", "The oligomer can have a duplex structure of from 14 to 29 monomers in length.", "The UNA oligomer can be targeted to a target gene and can exhibit reduced off-target effects as compared to a conventional siRNA.", "In some embodiments, a UNA oligomer of this invention can have a first strand and a second strand, each of the strands being 19-23 monomers in length.", "In another aspect, the UNA oligomer may have a blunt end, or may have one or more overhangs.", "In some embodiments, the first and second strands may be connected with a connecting oligomer in between the strands, and form a duplex region with a connecting loop at one end.", "In certain embodiments, an overhang can be one or two monomers in length.", "Examples of an overhang can contain one or more UNA monomers, natural nucleotides, non-natural nucleotides, modified nucleotides, or chemically-modified nucleotides, and combinations thereof.", "Examples of an overhang can contain one or more deoxythymidine nucleotides, 2′-O-methyl nucleotides, inverted abasic monomers, inverted thymidine monomers, L-thymidine monomers, or glyceryl nucleotides.", "A UNA oligomer can mediate cleavage of a target nucleic acid in a cell.", "In some processes, the second strand of the UNA oligomer, at least a portion of which can be complementary to the target nucleic acid, can act as a guide strand that can hybridize to the target nucleic acid.", "The second strand can be incorporated into an RNA Induced Silencing Complex (RISC).", "In some embodiments, a UNA oligomer may have a strand that is a DICER substrate.", "A UNA oligomer of this disclosure may comprise naturally-occurring nucleic acid nucleotides, and modifications thereof that are compatible with gene silencing activity.", "In some aspects, a UNA oligomer is a double stranded construct molecule that is able to inhibit gene expression.", "As used herein, the term strand refers to a single, contiguous chain of monomers, the chain having any number of internal monomers and two end monomers, where each end monomer is attached to one internal monomer on one side, and is not attached to a monomer on the other side, so that it ends the chain.", "The monomers of a UNA oligomer may be attached via phosphodiester linkages, phosphorothioate linkages, gapped linkages, and other variations.", "In some embodiments, a UNA oligomer can include mismatches in complementarity between the first and second strands.", "In other embodiments, a UNA oligomer may have 1, or 2, or 3 mismatches.", "The mismatches may occur at any position in the duplex region.", "The target of a UNA oligomer can be a target nucleic acid of a target gene.", "A UNA oligomer may have one or two overhangs outside the duplex region.", "The overhangs can be an unpaired portion at the end of the first strand or second strand.", "The lengths of the overhang portions of the first and second strands can be the same or different.", "A UNA oligomer may have at least one blunt end.", "A blunt end does not have an overhang portion, and the duplex region at a blunt end terminates at the same position for both the first and second strands.", "A UNA oligomer can be RISC length, which means that it has a duplex length of less than 25 base pairs.", "In certain embodiments, a UNA oligomer can be a single strand that folds upon itself and hybridizes to itself to form a double stranded region having a connecting loop at the end of the double stranded region.", "Examples of UNA oligomer structures of this invention are shown in Table 1.TABLE 1 Examples of UNA oligomer structures.", "First strand Second strand Oligomer 1 to 3′ 5′ to 3′ P15U6 SEQ ID NO: 3 SEQ ID NO: 4 ĞGCCAUGCAUGUGUUCAGAŨmU UCUGAÃCACAUGCAUGGCCŨmU P15U7 SEQ ID NO: 5 SEQ ID NO: 6 ĞGCCAUGCAUGUGUUCAGAŨmU UCUGAAĈACAUGCAUGGCCŨmU P15U14 SEQ ID NO: 7 SEQ ID NO: 8 ĞGCCAUGCAUGUGUUCAGAŨmU UCUGAACACAUGCÃUGGCCŨmU P15U15 SEQ ID NO: 9 SEQ ID NO: 10 ĞGCCAUGCAUGUGUUCAGAŨmU UCUGAACACAUGCAŨGGCCŨmU P15U16 SEQ ID NO: 11 SEQ ID NO: 12 ĞGCCAUGCAUGUGUUCAGAŨmU UCUGAACACAUGCAUĞGCCŨmU Examples of UNA oligomer structures of this invention are shown in Table 2.TABLE 2 Examples of UNA oligomer structures.", "First strand Second strand Oligomer 1 to 3′ 5′ to 3′ P16U6 SEQ ID NO: 13 SEQ ID NO: 14 ĞCCAUGCAUGUGUUCAGAAŨmU UUCUGÃACACAUGCAUGGCŨmU P16U7 SEQ ID NO: 15 SEQ ID NO: 16 ĞCCAUGCAUGUGUUCAGAAŨmU UUCUGAÃCACAUGCAUGGCŨmU P16U15 SEQ ID NO: 17 SEQ ID NO: 18 ĞCCAUGCAUGUGUUCAGAAŨmU UUCUGAACACAUGCÃUGGCŨmU P16U16 SEQ ID NO: 19 SEQ ID NO: 20 ĞCCAUGCAUGUGUUCAGAAŨmU UUCUGAACACAUGCAŨGGCŨmU P16U17 SEQ ID NO: 21 SEQ ID NO: 22 ĞCCAUGCAUGUGUUCAGAAŨmU UUCUGAACACAUGCAUĞGCŨmU Examples of sequences of UNA oligomers of this invention targeted to a TTR component are shown in Table 3.“Ref Pos” refers to reference position, which is the numerical position of a reference nucleotide in a TTR mRNA.", "In Table 3, a UNA oligomer would be composed of pairs SEQ ID NOs:23 and 63, 24 and 64, etc.", "TABLE 3 UNA oligomers for TTR component target sequences SEQ SEQ REF ID Sense (5′-3′) ID Antisense (5′-3′) POS NO SEQ ID NOS: 23 to 62 NO SEQ ID NOS: 63 to 102 626 23 AUGUAACCAAGAGUAUUCCAUUUUUac 63 GUAAAAAUGGAAUACUCUUGGUUACAU 626 24 AUGUAACCAAGAGUAUUCCAUUUUUac 64 GUAAAAAUGGAAUACUCUUGGUUACĀŨ 626 25 ĀŨGUAACCAAGAGUAUUCCAUUUUUac 65 GUAAAAAUGGAAUACUCUUGGUUACAU 626 26 ĀŨGUAACCAAGAGUAUUCCAUUUUUac 66 GUAAAAAUGGAAUACUCUUGGUUACĀŨ 626 27 AUGUAACCAAGAGUAUUCCAUUUUUĀĈ 67 GUAAAAAUGGAAUACUCUUGGUUACĀŨ 626 28 AUGUAACCAAGAGUAUUCCĀŨUUUUac 68 GUAAAAAUGGAAŨACUCUUGGUUACĀŨ 628 29 GUAACCAAGAGUAUUCCAUUUUUACta 69 UAGUAAAAAUGGAAUACUCUUGGUUAC 628 30 ĜŨAACCAAGAGUAUUCCAUUUUUACta 70 UAGUAAAAAUGGAAUACUCUUGGUUAC 628 31 GUAACCAAGAGUAUUCCAUUUUUACta 71 UAGUAAAAAUGGAAUACUCUUGGUUĀĈ 628 32 ĜŨAACCAAGAGUAUUCCAUUUUUACta 72 UAGUAAAAAUGGAAUACUCUUGGUUĀĈ 628 33 GUAACCAAGAGUAUUCCAUUUUUACŨĀ 73 UAGUAAAAAUGGAAUACUCUUGGUUĀĈ 628 34 GUAACCAAGAGUAUUCCAUŨŨUUACUA 74 UAGUAAAAAUGGAĀUACUCUUGGUUĀĈ 628 35 ĜUAACCAAGAGUAUUCCAUtt 75 AUGGAAUACUCUUGGUUACtt 628 36 GUAACCAAGAGUAUUCCAUtt 76 AUGGAAUACUCUUGGUUACŨŨ 628 37 ĜUAACCAAGAGUAUUCCAUtt 77 AUGGAAUACUCUUGGUUACŨŨ 628 38 GUAACCAAGAGUAUUCCAUŨŨ 78 AUGGAAUACUCUUGGUUACŨŨ 628 39 ĜUAACCAAGAGUAUUCCAUŨŨ 79 AUGGAAUACUCUUGGUUACŨŨ 628 40 GUAACCAAGAGUAUUCCAUŨŨ 80 AUGGAAŨACUCUUGGUUACŨŨ 628 41 ĞUAACCAAGAGUAUUCCAUŨŨ 81 AUGGAAŨACUCUUGGUUACŨŨ 628 42 ĞUAACCAAGAGUAUUCCAUŨŨ 82 AUGGAAŨACUCUUGGUUACAŨ 628 43 ĞUAACCAAGAGUAUUCCAUŨmU 83 AUGGAAUACUCUUGGUUACŨmU 628 44 ĞUAACCAAGAGUAUUCCAUŨmU 84 AUGĞAAUACUCUUGGUUACŨmU 628 45 ĞUAACCAAGAGUAUUCCAUŨmU 85 AUGGĀAUACUCUUGGUUACŨmU 628 46 ĞUAACCAAGAGUAUUCCAUŨmU 86 AUGGAĀUACUCUUGGUUACŨmU 626 47 ĀUGUAACCAAGAGUAUUCCŨmU 87 GGAĀUACUCUUGGUUACAUŨmU 626 48 ĀUGUAACCAAGAGUAUUCCŨmU 88 GGAAUACUCUUGGUUACAUŨmU 626 49 ĀUGUAACCAAGAGUAUUCCŨmU 89 GGAAŨACUCUUGGUUACAUŨmU 626 50 ĀUGUAACCAAGAGUAUUCŨmU 90 GGAAUĀCUCUUGGUUACAUŨmU 635 51 ĀGAGUAUUCCAUUUUUACŨmU 91 AGUAAAAAUGGAAUACUCŨmU 635 52 ĀGAGUAUUCCAUUUUUACŨmU 92 AGUĀAAAAUGGAAUACUCUmU 635 53 ĀGAGUAUUCCAUUUUUACŨmU 93 AGUAĀAAAUGGAAUACUCUmU 635 54 ĀGAGUAUUCCAUUUUUACŨmU 94 AGUAAĀAAUGGAAUACUCŨmU 174 55 ĞACUGGUAUUUGUGUCUGAŨmU 95 UCAGACACAAAUACCAGUCĈmA 174 56 ĞACUGGUAUUUGUGUCUGAŨmU 96 UCAĞACACAAAUACCAGUCĈmA 174 57 ĞACUGGUAUUUGUGUCUGAŨmU 97 UCAGĀCACAAAUACCAGUCĈmA 174 58 ĞACUGGUAUUUGUGUCUGAŨmU 98 UCAGAĈACAAAUACCAGUCĈmA 627 59 ŨGUAACCAAGAGUAUUCCAŨmU 99 UGGAAUACUCUUGGUUACAŨmU 629 60 ŨAACCAAGAGUAUUCCAUUŨmU 100 AAUGGAAUACUCUUGGUUAŨmU 632 61 ĈCAAGAGUAUUCCAUUUUUŨmU 101 AAAAAUGGAAUACUCUUGGŨmU 632 62 ĈCAAGAGUAUUCCAUUUUUŨmU 102 AAAAAUĜGAAUACUCUUGGŨmU In Table 3, lower case designates 2′-deoxyribo-N; upper case designates Ribo-N; underlined-lower case designates 2′-deoxy-N; mA, mG, mC, and mU designate 2′-O-Methyl RNA; and Ā Ũ Ğ and Ĉ designate UNA monomers.", "In certain embodiments, a UNA oligomer may have a duplex region, and have a UNA monomer in the second strand within the duplex region, where the UNA monomer in the second strand is present in any of positions 1 through 19, counting from the 5′ end of the second strand.", "In certain embodiments, a UNA oligomer may have a duplex region, and have a UNA monomer in the second strand within the duplex region, where the UNA monomer in the second strand is present in any of positions 6, 7, 14, 15 and 16, counting from the 5′ end of the second strand.", "In some embodiments, a UNA oligomer may comprise an overhang portion of two monomers in length, or longer, at the 3′ end of the first strand, wherein the overhang monomer immediately flanking the duplex portion is a UNA monomer.", "In some embodiments, a UNA oligomer may comprise an overhang portion of two monomers in length, or longer, at the 3′ end of the second strand, wherein the overhang monomer immediately flanking the duplex portion is a UNA monomer.", "Methods for Treating Amyloidosis Methods of this invention include the treatment and prevention of TTR-related amyloidosis in human and mammalian subjects.", "In the methods of this invention, a subject in need of treatment or prevention can be administered an effective amount of a UNA oligomer.", "Administration can be performed for 1, 2, or up to 7 days, or 1, 2, 3, or up to 4 weeks, or longer.", "The subject may have TTR-related amyloidosis, also known as ATTR.", "In particular, a subject can have a V30M gene.", "The methods of this invention can selectively reduce V30M TTR in the subject.", "In some embodiments, a method of this invention can selectively reduce V30M TTR in the subject by at least 10%, as compared to control.", "In certain embodiments, V30M TTR in the subject can be reduced by at least 20%, or 30%, or 50%, as compared to control.", "An effective amount of a UNA oligomer of this invention can be a dose ranging from 0.001 mg/kg to 50.0 mg/kg, or from 0.001 mg/kg to 10.0 mg/kg.", "In the methods of this invention, TTR mRNA expression can be reduced in a subject for at least 5 days.", "In certain embodiments, TTR mRNA expression can be reduced in a subject for at least 10 days, or 15 days.", "In the methods of this invention, peripheral neuropathy or autonomic neuropathy in the subject can be reduced.", "In the methods of this invention, peripheral neuropathy or autonomic neuropathy in the subject can be reduced.", "In some embodiments, a subject may undergo reduced lower extremity weakness, reduced pain, or improved sensation.", "Methods of this invention can reduce occurrence of vitreous opacities in the subject.", "In the methods of this disclosure, the administration of a UNA oligomer may not result in an inflammatory response.", "In further embodiments, this invention includes methods for inhibiting expression of a TTR gene in a cell, by treating the cell with a UNA oligomer.", "In additional embodiments, this invention includes methods for inhibiting expression of a TTR gene in a mammal, by administering to the mammal a composition containing a UNA oligomer.", "Pharmaceutical Compositions In some aspects, this invention provides compositions containing a UNA oligomer and a pharmaceutically acceptable carrier.", "In further aspects, this invention includes nanoparticle compositions that can encapsulate and deliver a UNA oligomer to cells with surprisingly advantageous potency.", "The nanoparticles can be formed with lipid molecules, for example, any one or more of the compounds ATX-001 to ATX-032 disclosed in WO/2015/074085.In certain embodiments, lipid nanoparticles of this invention can be formed with compound ATX-002, as disclosed in WO/2015/074085, and the nanoparticles can encapsulate the UNA oligomer.", "A composition can be capable of local or systemic administration.", "In some aspects, a pharmaceutical composition can be capable of any modality of administration.", "In certain aspects, the administration can be intravenous, subcutaneous, pulmonary, intramuscular, intraperitoneal, dermal, oral, or nasal administration.", "Embodiments of this invention include pharmaceutical compositions containing a UNA oligomer in a lipid formulation.", "In some embodiments, a composition may comprise one or more lipids selected from cationic lipids, anionic lipids, sterols, pegylated lipids, and any combination of the foregoing.", "In certain embodiments, a composition can be substantially free of liposomes.", "In further embodiments, a composition can include liposomes.", "In additional embodiments, a composition can contain a UNA oligomer within a viral or bacterial vector.", "A pharmaceutical composition of this disclosure may include carriers, diluents or excipients as are known in the art.", "Examples of pharmaceutical compositions are described, for example, in Remington's Pharmaceutical Sciences, Mack Publishing Co. (A. R. Gennaro ed.", "1985).", "Examples of excipients for a pharmaceutical composition include antioxidants, suspending agents, dispersing agents, preservatives, buffering agents, tonicity agents, and surfactants.", "EXAMPLES Example 1 FIG.", "1 shows the single nucleotide polymorph (SNP) that exists at position 284 in the V30M mutation of the human TTR mRNA, as compared to the wild type (WT) TTR mRNA.", "Conventional siRNAs that are complementary to the WT mRNA were tiled around position 284.FIG.", "2 shows that the conventional siRNAs complementary to the WT mRNA have limited activity in silencing the WT TTR gene, as measured by TTR knockdown in HepG2 cells.", "Positions 5, 9, 14 and 15 appear to be more accessible to silencing than other positions.", "FIG.", "3 shows conventional siRNAs that were complementary to the V30M mRNA were tiled around position 284.Four conventional siRNA variations, namely V30M-P5, V30M-P9, V30M-P14, and V30M-P15, were prepared.", "Also, as shown in FIG.", "3, two gene reporter variants, V30V and V30M, each bearing nucleotide sequence 264 to 304 of human TTR, V30V being without the point mutation at position 284, and V30M containing the point mutation at position 284, were prepared and used in the PSICHECK reporter system in the 3′-UTR region of Luciferase gene.", "Example 2 FIG.", "4 shows the activity of the four conventional siRNA variations V30M-P5, V30M-P9, V30M-P14, and V30M-P15 as measured in the PSICHECK reporter assay against V30V and V30M gene reporter variants.", "The conventional siRNA variations V30M-P5, V30M-P9, and V30M-P15 were more effective against V30M than V30V.", "The conventional siRNA variation V30M-P14 was not more effective against V30M than V30V.", "FIG.", "5 shows IC50 analysis for the four conventional siRNA variations V30M-P5, V30M-P9, V30M-P14, and V30M-P15 measured in the PSICHECK reporter assay against V30V and V30M gene reporter variants.", "The conventional V30M-P15 variant was 5.6 times more effective against V30M than V30V.", "Thus, the selectivity of the conventional siRNAs against V30M over V30V was no more than 5.6.Example 3 FIG.", "6 shows the structure of UNA oligomers that were effective in silencing V30M TTR, as measured in the PSICHECK reporter assay.", "Each of the UNA oligomer embodiments, P15U6, P15U7, P15U14, P15U15, and P15U16, contained four UNA monomers.", "In each UNA oligomer, a first UNA monomer was located at the 5′ end of the first strand, also called the passenger strand.", "In each UNA oligomer, the second strand, also called the guide strand, formed a duplex region of 19 monomers length with the first strand.", "Each UNA oligomer had a duplex region of 19 monomers, and a two-monomer overhang at each end.", "In each UNA oligomer, a second UNA monomer was located at the 3′ end of the first strand, in the 20th position, which is in an overhang portion.", "In each UNA oligomer, a third UNA monomer was located at the 3′ end of the second strand, in the 20th position, which is in an overhang portion.", "In the UNA oligomer embodiments, P15U6, P15U7, P15U14, P15U15, and P15U16, a fourth UNA monomer was located in the second strand at positions 6, 7, 14, 15 and 16, respectively, counting from the 5′ end of the second strand.", "Example 4 FIG.", "7 shows the activity of UNA oligomers P15U6, P15U7, P15U15, and P15U16, measured in the PSICHECK reporter assay against V30V and V30M gene reporter variants, as compared to the conventional siRNA V30M-P15.For each of the UNA oligomer embodiments, P15U6, P15U7, P15U15, and P15U16, the UNA oligomers were more effective against V30M than V30V.", "Surprisingly, the activity of the UNA oligomer P15U6 was substantially and advantageously superior to the activity of the conventional siRNA V30M-P15, where each is targeted to V30M.", "Furthermore, FIG.", "7 shows the surprising and unexpected result that the selectivity of the UNA oligomers, P15U6, P15U7, P15U15, and P15U16, against V30M over V30V was substantially greater than for the conventional siRNA V30M-P15.In particular, the selectivity of UNA oligomer P15U6 against V30M over V30V was 24, meaning that the IC50 of UNA oligomer P15U6 against V30M (37.6 pM) was 24 times lower than the IC50 of UNA oligomer P15U6 against V30V (919.9 pM).", "This selectivity was advantageously 4-fold superior to the selectivity of 5.6 shown by the conventional siRNA.", "Example 5 FIG.", "8 shows the structure of UNA oligomers that were effective in silencing V30M TTR, as measured in the PSICHECK reporter assay.", "Each of the UNA oligomer embodiments, P16U6, P16U7, P16U15, P16U16, and P16U17, contained four UNA monomers.", "In each UNA oligomer, a first UNA monomer was located at the 5′ end of the first strand, also called the passenger strand.", "In each UNA oligomer, the second strand, also called the guide strand, formed a duplex region of 19 monomers length with the first strand.", "Each UNA oligomer had a duplex region of 19 monomers, and a two-monomer overhang at each end.", "In each UNA oligomer, a second UNA monomer was located at the 3′ end of the first strand, in the 20th position, which is in an overhang portion.", "In each UNA oligomer, a third UNA monomer was located at the 3′ end of the second strand, in the 20th position, which is in an overhang portion.", "In the UNA oligomer embodiments, P16U6, P16U7, P16U15, P16U16, and P16U17, a fourth UNA monomer was located in the second strand at positions 6, 7, 15, 16 and 17, respectively, counting from the 5′ end of the second strand.", "Example 6 FIG.", "9 shows the activity of UNA oligomers P16U6, P16U7, P16U15, and P16U16, measured in the PSICHECK reporter assay against V30V and V30M gene reporter variants, as compared to the conventional siRNA V30M-P16.For each of the UNA oligomer embodiments, P16U6, P16U7, P16U15, and P16U16, the UNA oligomers were more effective against V30M than V30V.", "Surprisingly, the activity of each of the UNA oligomers P16U6, P16U7, P16U15, and P16U16, was substantially and advantageously superior to the activity of the conventional siRNA V30M-P16, where each is targeted to V30M.", "Furthermore, FIG.", "9 shows the surprising and unexpected result that the selectivity of the UNA oligomers, P16U6, P16U7, P16U15, and P16U16, against V30M over V30V was substantially greater than for the conventional siRNA V30M-P16.In particular, the selectivity of UNA oligomer P16U6 against V30M over V30V was 23, meaning that the IC50 of UNA oligomer P16U6 against V30M (92.4 pM) was 23 times lower than the IC50 of UNA oligomer P16U6 against V30V (2119 pM).", "This selectivity was advantageously 4-fold superior to the selectivity of 5.6 shown by the conventional siRNA.", "FIG.", "10 (left) shows the selectivity of UNA oligomer P15U6 against V30M over V30V.", "The IC50 of UNA oligomer P15U6 against V30M (37.6 pM) was 24 times lower than the IC50 of UNA oligomer P15U6 against V30V (919.9 pM).", "This selectivity was advantageously 4-fold superior to the selectivity of 5.6 shown by the conventional siRNA.", "FIG.", "10 (right) shows the surprising and unexpected result that the IC50 of UNA oligomer P16U6 against V30M (92.4 pM) was 23 times lower than the IC50 of UNA oligomer P16U6 against V30V (2119 pM).", "This selectivity was advantageously 4-fold superior to the selectivity of 5.6 shown by the conventional siRNA.", "Example 7: UNA Oligomers Reduce V30M TTR Deposits In Vivo Transgenic mice for human TTR V30M overexpression are used at 6 months age.", "TTR wild-type and TTR knockout mice are used as controls.", "Animals are housed in controlled environment, and euthanized with ketamine and medetomidine.", "For TTR gene silencing, the TTR UNA oligomer, as well as controls, are delivered in liposome formulations.", "Mice are injected in the tail vein with TTR UNA oligomer (n=6), at a concentration of 1 mg/kg.", "Untreated age-matched controls are treated with blank formulation.", "One injection is given per week for 4 weeks, and animals are sacrificed 48 h after last injection.", "Liver and colon are removed and collected to 10% formalin and frozen.", "Liver and colon mRNA are isolated using phenol extraction (Invitrogen).", "Sciatic nerve from V30M mice is dissected from other tissue, and mRNA is extracted with a RNeasy Mini column (Qiagen).", "cDNA is synthesized with a SuperScript double-stranded cDNA Kit (Invitrogen).", "Extracted RNA is validated with Experion RNA StdSens Analysis Kit (Bio-Rad).", "qPCR is performed with primers and iQ Syber Green Super Mix (Bio-Rad).", "Double immunofluorescence analysis is performed with sciatic nerve, dorsal root ganglia, and colon from V30M animals that is removed and treated as above.", "Comparisons are performed with Student T-test or One-way ANOVA.", "Data are expressed as mean values±standard error (SEM).", "p-values less than 0.05 are considered significant.", "Injection of a composition containing one or more UNA oligomers in V30M mice reduces the V30M TTR deposits in sciatic nerve, dorsal root ganglia, and colon by at least 90% over controls.", "Injection of a composition containing any one of UNA oligomers P15U6, P15U7, P15U15, or P15U16, or any combination of these UNA oligomers, in V30M mice reduces the V30M TTR deposits in sciatic nerve, dorsal root ganglia, and colon by at least 90% over controls.", "Example 8: UNA Oligomers Reduce TTR Protein In Vivo Primate A single-dose, pharmacokinetic and pharmacodynamic study of liposomally formulated UNA Oligomers targeting transthyretin (TTR) mRNA following intravenous infusion in Cynomolgus monkeys was performed.", "Cynomolgus monkeys (Macaca fascicularis) were selected for this study because the TTR mRNA of Cynomolgus monkeys is homologous to human TTR mRNA, making them a good model for screening the potency of UNA oligomers targeting to TTR mRNA.", "In this study, the knockdown of Transthyretin protein was evaluated as a result of treatment with UNA oligomers targeting Transthyretin TTR mRNA, based on SEQ ID NOs:46/86, 59/99, and 60/100, delivered in a liposomal formulation to male Cynomolgus monkeys.", "Measurements were made following a single intravenous (IV) dose administration.", "TTR protein concentration in plasma samples was assessed by LC-MS/MS at various time points.", "Twenty-four (24) Cynomolgus non-naïve and naïve monkeys were used in this study.", "There were eight (8) groups of animals in the study with three (3) per group and three (3) extra animals.", "The animals weighed 2.4 to 6.8 kg and were 3 to 6 years old at pre-study physical examination.", "Animals were housed in a temperature- and humidity-monitored environment.", "The targeted range of temperature and relative humidity was from 18° C. to 29° C., and from 35% to 70%, respectively.", "An automatic lighting system provided a 12-hour light/dark cycle.", "Previously quarantined animals were acclimated to the study room for a minimum of 14 days prior to initiation of dosing.", "Acclimation phase data was collected from all animals.", "Animals in Groups 1 through 8 were administered the test articles on Day 1 at 0.3 mg/kg, dose volume 6.25 mL/kg, concentration 0.048 mg/mL.", "Doses were administered as a 15-minute intravenous (IV) infusion, ±1 minute, using a pump and disposable syringe.", "For each animal, infusion start and end times were recorded; and subsequent sample collection target times were determined based on infusion end time (t=0).", "All blood specimens, approximately 1 mL, were collected by venipuncture from a peripheral vein from restrained, conscious animals.", "Knockdown of TTR was observed in all treated groups with observation at Days 10 and 20 after dosing.", "The study period was lengthened to 50 days for one group to observe long-term effects.", "Referring to FIG.", "11, knockdown of Transthyretin protein in vivo was achieved as a result of treatment with UNA oligomer SEQ ID NO:60/100 targeting Transthyretin TTR mRNA, delivered in a liposomal formulation to male Cynomolgus monkeys.", "Measurements were made following a single intravenous (IV) dose administration.", "TTR protein concentration in plasma samples was assessed by LC-MS/MS at various time points.", "As shown in FIG.", "11, a single injection in the primates of a UNA oligomer targeted to TTR surprisingly knocked down TTR protein levels to below 50% with a continuous duration of more than one month (30 days).", "FIG.", "11 shows the unexpectedly advantageous result of over 91% knockdown of TTR in the primates at 20 days, and more than 70% knockdown with a continuous duration of more than 20 days.", "The Monkey TTR SRM assay was used, which is a high throughput absolute protein quantitation assay using Selected Reaction Monitoring (SRM) technology platform.", "In a single SRM assay, the panel can multiplex up to 200 proteins.", "The assay was performed on a targeted absolute protein quantitation platform, where the key technology was SRM, sometimes also referred to as Multiple Reaction Monitoring (MRM).", "In a triple-quadrupole (QQQ) mass spectrometer, SRM/MRM is a tandem selection process where selecting peptides by precursor m/z is followed by selecting fragmentations (transitions) of the targeted peptide.", "Further, coupled with liquid chromatography and the addition of heavy labeled internal standards, SRM/MRM is a highly selective, sensitive technology to quantify designated protein with precision.", "All publications, patents and literature specifically mentioned herein are incorporated by reference for all purposes.", "It is understood that this invention is not limited to the particular methodology, protocols, materials, and reagents described, as these may vary.", "It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention, which will be encompassed by the appended claims.", "It must be noted that as used herein and in the appended claims, the singular forms “a”, “an”, and “the” include plural reference unless the context clearly dictates otherwise.", "As well, the terms “a” (or “an”), “one or more” and “at least one” can be used interchangeably herein.", "It is also to be noted that the terms “comprises,” “comprising”, “containing,” “including”, and “having” can be used interchangeably.", "Without further elaboration, it is believed that one skilled in the art can, based on the above description, utilize the present invention to its fullest extent.", "The following specific embodiments are, therefore, to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever.", "All of the features disclosed in this specification may be combined in any combination.", "Each feature disclosed in this specification may be replaced by an alternative feature serving the same, equivalent, or similar purpose." ] ]
Patent_15876127
[ [ "Methods and Systems for LIDAR Optics Alignment", "A method is provided that involves mounting a transmit block and a receive block in a LIDAR device to provide a relative position between the transmit block and the receive block.", "The method also involves locating a camera at a given position at which the camera can image light beams emitted by the transmit block and can image the receive block.", "The method also involves obtaining, using the camera, a first image indicative of light source positions of one or more light sources in the transmit block and a second image indicative of detector positions of one or more detectors in the receive block.", "The method also involves determining at least one offset based on the first image and the second image.", "The method also involves adjusting the relative position between the transmit block and the receive block based at least in part on the at least one offset." ], [ "1.A method comprising: causing a light detection and ranging (LIDAR) device to emit one or more light beams toward a field-of-view (FOV) of the LIDAR device, wherein the LIDAR device includes one or more light detectors and a lens that focuses light from the FOV toward the one or more light detectors; capturing a plurality of images using a camera located at a given position in the FOV of the LIDAR device, wherein the one or more light detectors are viewable to the camera via the lens of the LIDAR device, and wherein the plurality of images include: a first image indicating a view of the one or more light beams from the given position of the camera, and a second image indicating a view of the one or more light detectors from the given position of the camera; and based on at least the plurality of images, adjusting the LIDAR device to align the one or more light beams with the one or more light detectors.", "2.The method of claim 1, wherein the one or more light beams propagate through the lens toward the camera, and wherein the first image indicates the view of the one or more light beams via the lens.", "3.The method of claim 1, wherein the LIDAR device includes one or more light sources that emit the one or more light beams.", "4.The method of claim 3, wherein the one or more light sources are viewable to the camera via the lens of the LIDAR device, and wherein the first image is indicative of a view of the one or more light sources via the lens of the LIDAR device.", "5.The method of claim 3, wherein adjusting the LIDAR device comprises mounting the one or more light sources in the LIDAR device.", "6.The method of claim 3, wherein adjusting the LIDAR device comprises adjusting a position of the one or more light sources relative to the one or more light detectors in the LIDAR device.", "7.The method of claim 3, wherein adjusting the LIDAR device comprises adjusting a position of the one or more light detectors relative to the one or more light sources in the LIDAR device.", "8.The method of claim 1, wherein adjusting the LIDAR device comprises mounting the one or more light detectors in the LIDAR device.", "9.The method of claim 1, further comprising: comparing the first image with the second image, wherein adjusting the LIDAR device is further based on the comparison.", "10.The method of claim 1, further comprising: moving a light filter to a first position between the camera and the LIDAR device, wherein the one or more light beams propagate through the light filter based on the light filter being at the first position, and wherein capturing the plurality of images comprises: capturing the first image while the light filter is at the first position, and capturing the second image while the light filter is at a second position outside a path of the one or more light beams.", "11.The method of claim 10, further comprising: prior to capturing the second image, moving the light filter from the first position to the second position.", "12.The method of claim 1, further comprising: illuminating the one or more light detectors with an auxiliary light source, wherein capturing the plurality of images comprises capturing the second image while the one or more light detectors are illuminated by the auxiliary light source.", "13.The method of claim 12, wherein the auxiliary light source emits light at a source wavelength of the one or more light beams emitted by the LIDAR device.", "14.The method of claim 12, wherein capturing the plurality of images comprises capturing the first image while the one or more light detectors are not illuminated by the auxiliary light source.", "15.A system comprising: a mounting platform that supports a light detection and ranging (LIDAR) device, wherein the LIDAR device includes one or more light detectors and a lens that focuses light from a field-of-view (FOV) of the LIDAR device toward the one or more light detectors; a camera located at a given position in the FOV of the LIDAR device, wherein the one or more light detectors are viewable to the camera via the lens of the LIDAR device; and a controller that: causes the LIDAR device to emit one or more light beams toward the FOV of the LIDAR device; obtains a plurality of images using the camera, wherein the plurality of images include: a first image indicating a view of the one or more light beams from the given position of the camera, and a second image indicating a view of the one or more light detectors from the given position of the camera; and based on at least the plurality of images, identifies at least one alignment offset between the one or more light beams and the one or more light detectors.", "16.The system of claim 15, further comprising: an alignment apparatus that adjusts the LIDAR device based on the at least one identified alignment offset.", "17.The system of claim 17, further comprising: a light filter that attenuates light within a wavelength range that includes a source wavelength of the one or more light beams; and an actuator coupled to the light filter, wherein the controller causes the actuator to move the light filter to a first position between the camera and the LIDAR device, wherein the one or more light beams propagate through the light filter toward the camera based on the light filter being at the first position, and wherein obtaining the plurality of images comprises obtaining the first image while the light filter is at the first position.", "18.The system of claim 17, wherein the controller causes the actuator to move the light filter to a second position outside a path of the one or more light beams, wherein obtaining the plurality of images comprises obtaining the second image while the light filter is at the second position.", "19.A method comprising: causing a light detection and ranging (LIDAR) device to transmit one or more light beams toward a field-of-view (FOV) of the LIDAR device, wherein the LIDAR device includes one or more light detectors, a lens, and one or more light sources that emit the one or more light beams; capturing a plurality of images using a camera located at a given position in the FOV of the LIDAR device, wherein the one or more light detectors are viewable to the camera via the lens, wherein the one or more light sources are viewable to the camera via the lens, and wherein the plurality of images include: a first image indicating a view of the one or more light beams from the given position of the camera, and a second image indicating a view of the one or more light detectors from the given position of the camera; and based on at least the plurality of images, aligning the one or more light sources with the one or more light detectors.", "20.The method of claim 19, further comprising: interposing a light filter between the camera and the LIDAR device, wherein the light filter attenuates a source wavelength of the one or more light beams emitted by the LIDAR device, and wherein capturing the plurality of images comprises: capturing the first image while the light filter is interposed between the camera and the LIDAR device, and capturing the second image while the light filter is not interposed between the camera and the LIDAR device." ], [ "<SOH> BACKGROUND <EOH>Unless otherwise indicated herein, the materials described in this section are not prior art to the claims in this application and are not admitted to be prior art by inclusion in this section.", "A LIDAR can estimate distance to environmental features while scanning through a scene to assemble a “point cloud” indicative of reflective surfaces in the environment.", "Individual points in the point cloud can be determined by transmitting a laser pulse and detecting a returning pulse, if any, reflected from an object in the environment, and determining the distance to the object according to the time delay between the transmission of the transmitted pulse and the reception of the reflected pulse.", "A laser, or set of lasers, can be rapidly and repeatedly scanned across a scene to provide continuous real-time information on distances to reflective objects in the scene.", "Combining the measured distances and the orientation of the laser(s) while measuring each distance allows for associating a three-dimensional position with each returning pulse.", "In this way, a three-dimensional map of points indicative of locations of reflective features in the environment can be generated for the entire scanning zone." ], [ "<SOH> SUMMARY <EOH>In one example, a method is provided that involves mounting a transmit block and a receive block in a light detection and ranging (LIDAR) device to provide a relative position between the transmit block and the receive block.", "The transmit block may include one or more light sources configured to emit light at a source wavelength.", "The receive block may include one or more detectors configured to detect light at the source wavelength.", "The method further involves locating a camera at a given position at which the camera, when focused at infinity, can image light beams emitted by the one or more light sources and can image the one or more detectors.", "The method further involves obtaining a first image using the camera located at the given position and focused at infinity.", "The first image may be indicative of light source positions of the one or more light sources.", "The method further involves obtaining a second image using the camera located at the given position and focused at infinity.", "The second image may be indicative of detector positions of the one or more detectors in the receive block.", "The method further involves determining at least one offset based on the light source positions indicated by the first image and the detector positions indicated by the second image.", "The method further involves adjusting the relative position between the transmit block and the receive block based at least in part on the at least one offset.", "In another example, a system is provided that includes a mounting platform to mount a light detection and ranging (LIDAR) device that provides a relative position between a transmit block in the LIDAR device and a receive block in the LIDAR device.", "The transmit block may include one or more light sources configured to emit light at a source wavelength.", "The receive block may include one or more detectors configured to detect light at the source wavelength.", "The system also includes a camera located at a given position at which the camera, when focused at infinity, can image light beams emitted by the one or more light sources and can image the one or more detectors.", "The system also includes an alignment apparatus configured to adjust the relative position between the transmit block and the receive block.", "The system also includes a controller configured to obtain a first image from the camera located at the given position and focused at infinity.", "The first image may be indicative of light source positions of the one or more light sources.", "The controller is also configured to obtain a second image from the camera located at the given position and focused at infinity.", "The second image may be indicative of detector positions of the one or more detectors in the receive block.", "The controller is also configured to determine at least one offset based on the light source positions indicated by the first image and the detector positions indicated by the second image.", "The controller is also configured to cause the alignment apparatus to adjust the relative position between the transmit block and the receive block based at least in part on the at least one offset.", "In yet another example, a system is provided that includes a means for mounting a transmit block and a receive block in a light detection and ranging (LIDAR) device to provide a relative position between the transmit block and the receive block.", "The transmit block may include one or more light sources configured to emit light at a source wavelength.", "The receive block may include one or more detectors configured to detect light at the source wavelength.", "The system also comprises means for locating a camera at a given position at which the camera, when focused at infinity, can image light beams emitted by the one or more light sources and can image the one or more detectors.", "The system also comprises means for obtaining a first image using the camera located at the given position and focused at infinity.", "The first image may be indicative of light source positions of the one or more light sources.", "The system also comprises means for obtaining a second image using the camera located at the given position and focused at infinity.", "The second image may be indicative of detector positions of the one or more detectors in the receive block.", "The system also comprises means for determining at least one offset based on the light source positions indicated by the first image and the detector positions indicated by the second image.", "The system also comprises means for adjusting the relative position between the transmit block and the receive block based at least in part on the at least one offset.", "These as well as other aspects, advantages, and alternatives, will become apparent to those of ordinary skill in the art by reading the following detailed description, with reference where appropriate to the accompanying figures." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "15/482,722 filed on Apr.", "8, 2017, which is a continuation of U.S. patent application Ser.", "No.", "14/671,085 filed on Mar.", "27, 2015, the entire contents of each of which are incorporated herein by reference.", "BACKGROUND Unless otherwise indicated herein, the materials described in this section are not prior art to the claims in this application and are not admitted to be prior art by inclusion in this section.", "A LIDAR can estimate distance to environmental features while scanning through a scene to assemble a “point cloud” indicative of reflective surfaces in the environment.", "Individual points in the point cloud can be determined by transmitting a laser pulse and detecting a returning pulse, if any, reflected from an object in the environment, and determining the distance to the object according to the time delay between the transmission of the transmitted pulse and the reception of the reflected pulse.", "A laser, or set of lasers, can be rapidly and repeatedly scanned across a scene to provide continuous real-time information on distances to reflective objects in the scene.", "Combining the measured distances and the orientation of the laser(s) while measuring each distance allows for associating a three-dimensional position with each returning pulse.", "In this way, a three-dimensional map of points indicative of locations of reflective features in the environment can be generated for the entire scanning zone.", "SUMMARY In one example, a method is provided that involves mounting a transmit block and a receive block in a light detection and ranging (LIDAR) device to provide a relative position between the transmit block and the receive block.", "The transmit block may include one or more light sources configured to emit light at a source wavelength.", "The receive block may include one or more detectors configured to detect light at the source wavelength.", "The method further involves locating a camera at a given position at which the camera, when focused at infinity, can image light beams emitted by the one or more light sources and can image the one or more detectors.", "The method further involves obtaining a first image using the camera located at the given position and focused at infinity.", "The first image may be indicative of light source positions of the one or more light sources.", "The method further involves obtaining a second image using the camera located at the given position and focused at infinity.", "The second image may be indicative of detector positions of the one or more detectors in the receive block.", "The method further involves determining at least one offset based on the light source positions indicated by the first image and the detector positions indicated by the second image.", "The method further involves adjusting the relative position between the transmit block and the receive block based at least in part on the at least one offset.", "In another example, a system is provided that includes a mounting platform to mount a light detection and ranging (LIDAR) device that provides a relative position between a transmit block in the LIDAR device and a receive block in the LIDAR device.", "The transmit block may include one or more light sources configured to emit light at a source wavelength.", "The receive block may include one or more detectors configured to detect light at the source wavelength.", "The system also includes a camera located at a given position at which the camera, when focused at infinity, can image light beams emitted by the one or more light sources and can image the one or more detectors.", "The system also includes an alignment apparatus configured to adjust the relative position between the transmit block and the receive block.", "The system also includes a controller configured to obtain a first image from the camera located at the given position and focused at infinity.", "The first image may be indicative of light source positions of the one or more light sources.", "The controller is also configured to obtain a second image from the camera located at the given position and focused at infinity.", "The second image may be indicative of detector positions of the one or more detectors in the receive block.", "The controller is also configured to determine at least one offset based on the light source positions indicated by the first image and the detector positions indicated by the second image.", "The controller is also configured to cause the alignment apparatus to adjust the relative position between the transmit block and the receive block based at least in part on the at least one offset.", "In yet another example, a system is provided that includes a means for mounting a transmit block and a receive block in a light detection and ranging (LIDAR) device to provide a relative position between the transmit block and the receive block.", "The transmit block may include one or more light sources configured to emit light at a source wavelength.", "The receive block may include one or more detectors configured to detect light at the source wavelength.", "The system also comprises means for locating a camera at a given position at which the camera, when focused at infinity, can image light beams emitted by the one or more light sources and can image the one or more detectors.", "The system also comprises means for obtaining a first image using the camera located at the given position and focused at infinity.", "The first image may be indicative of light source positions of the one or more light sources.", "The system also comprises means for obtaining a second image using the camera located at the given position and focused at infinity.", "The second image may be indicative of detector positions of the one or more detectors in the receive block.", "The system also comprises means for determining at least one offset based on the light source positions indicated by the first image and the detector positions indicated by the second image.", "The system also comprises means for adjusting the relative position between the transmit block and the receive block based at least in part on the at least one offset.", "These as well as other aspects, advantages, and alternatives, will become apparent to those of ordinary skill in the art by reading the following detailed description, with reference where appropriate to the accompanying figures.", "BRIEF DESCRIPTION OF THE FIGURES FIG.", "1 is a block diagram of a system, according to an example embodiment.", "FIG.", "2A illustrates a LIDAR device, according to an example embodiment.", "FIG.", "2B is a cross-section view of the LIDAR device shown in FIG.", "2A.", "FIG.", "2C is a perspective view of the LIDAR device shown in FIG.", "2A with various components removed to illustrate an interior of the LIDAR device.", "FIG.", "3 illustrates a transmit block, according to an example embodiment.", "FIG.", "4A is a view of a light source, according to an example embodiment.", "FIG.", "4B is a view of the light source of FIG.", "4A in combination with a cylindrical lens, according to an example embodiment.", "FIG.", "4C is another view of the light source and cylindrical lens combination of FIG.", "4B, according to an example embodiment.", "FIG.", "5A illustrates a receive block, according to an example embodiment.", "FIG.", "5B illustrates a side view of three detectors included in the receive block of FIG.", "5A.", "FIG.", "6A illustrates another LIDAR device, according to an example embodiment.", "FIG.", "6B illustrates a partial cross-section view of the LIDAR device of FIG.", "6A.", "FIG.", "6C illustrates a partial cross-section view of the optics assembly in the FIG.", "7A illustrates a system, according to an example embodiment.", "FIG.", "7B illustrates an arrangement of the system shown in FIG.", "7A where the light filter is not interposed between the LIDAR device and the camera.", "FIG.", "7C illustrates a partial view of the system shown in FIGS.", "7A-7B.", "FIG.", "8 illustrates another system, according to an example embodiment.", "FIG.", "9 is a flowchart of a method, according to an example embodiment.", "FIG.", "10 illustrates an image indicative of light source positions, according to an example embodiment.", "FIG.", "11 illustrates an image indicative of detector positions, according to an example embodiment.", "FIG.", "12 illustrates an image in a scenario where light sources and detectors are aligned, according to an example embodiment.", "FIG.", "13 illustrates an image in a scenario where light sources and detectors have an up/down offset, according to an example embodiment.", "FIG.", "14 illustrates an image in a scenario where light sources and detectors have a left/right offset, according to an example embodiment.", "FIG.", "15 illustrates an image in a scenario where light sources and detectors have a forward/backward offset, according to an example embodiment.", "FIG.", "16 illustrates an image in a scenario where light sources and detectors have a roll offset, according to an example embodiment.", "FIG.", "17 illustrates an image in a scenario where light sources and detectors have a yaw offset, according to an example embodiment.", "FIG.", "18 illustrates an image in a scenario where light sources and detectors have a pitch offset, according to an example embodiment.", "FIG.", "19 illustrates an image indicative of a defect or an aberration, according to an example embodiment.", "FIG.", "20 is a flowchart of another method, according to an example embodiment.", "FIG.", "21 illustrates a partial cross-section view of yet another system, according to an example embodiment.", "FIG.", "22 illustrates a front-view of a camera, according to an example embodiment.", "DETAILED DESCRIPTION The following detailed description describes various features and functions of the disclosed systems, devices and methods with reference to the accompanying figures.", "In the figures, similar symbols identify similar components, unless context dictates otherwise.", "The illustrative system, device and method embodiments described herein are not meant to be limiting.", "It may be readily understood by those skilled in the art that certain aspects of the disclosed systems, devices and methods can be arranged and combined in a wide variety of different configurations, all of which are contemplated herein.", "Within examples, a LIDAR device may include a transmit block and a receive block.", "The transmit block may include one or more light sources that transmit light for propagation away from the LIDAR device toward an environment of the LIDAR device.", "In turn, the transmitted light may reflect off one or more objects in the environment, and the reflected light may propagate back toward the LIDAR device.", "Further, the receive block may include one or more detectors to detect the reflected light.", "Through this process, a computing system may process data from the LIDAR device pertaining to the reflected light to determine positions and/or characteristics of various objects in the environment of the LIDAR device.", "To facilitate operation of the LIDAR device, a light beam emitted by a given light source and reflected back toward the LIDAR device is received by a corresponding detector.", "Within examples, systems and methods are provided for alignment of light source(s) and detector(s) in a LIDAR device.", "FIG.", "1 is a block diagram of a system 100, according to an example embodiment.", "The system 100 includes a mounting platform 102, an alignment apparatus 160, and a controller 180.The system 100 may optionally include an auxiliary light source 170.The mounting platform 102 may provide a platform for mounting some or all of the components of the system 100.As shown, the mounting platform 102 mounts a LIDAR device 104 and a camera 106.In some examples, the mounting platform 102 may also mount a light filter 108.Further, in some examples, the mounting platform 102 may also mount an actuator 112.Accordingly, the mounting platform 102 may be formed from one or more solid materials suitable for supporting the various components, such as plastics or metals among other possibilities.", "In some examples, some of the components shown to be mounted on the mounting platform 102 may alternatively be mounted to a separate structure (not shown) or otherwise coupled to the system 100.For instance, the camera 106 and/or the light filter 108 may be alternatively positioned and/or mounted outside the mounting platform 102.The LIDAR device 104 includes a transmit block 120 and a receive block 130.As shown, in some examples, the LIDAR device 104 may optionally include a lens 150.The transmit block 120 includes one or more light sources 122 that may be configured to emit one or more light beams 124.Although not shown in FIG.", "1, the transmit block 120 may include additional components such as a mirror or an exit aperture to condition and/or redirect the light beams 124.The one or more light sources 122 may include laser diodes, light emitting diodes (LEDs), vertical cavity surface emitting lasers (VCSEL), organic light emitting diodes (OLEDs), polymer light emitting diodes (PLED), light emitting polymers (LEP), liquid crystal displays (LCD), microelectromechanical systems (MEMS), or any other device configured to selectively transmit, reflect, and/or emit light beams 124 at a source wavelength.", "The source wavelength, for example, may include ultraviolet, visible, and/or infrared portions of the electromagnetic spectrum.", "In one embodiment, the source wavelength is 905 nm.", "Additionally, in some examples, the light sources 122 may be configured to emit the light beam(s) 124 in the form of pulses.", "In some examples, the light sources 122 may be disposed on one or more substrates (e.g., printed circuit boards (PCB), flexible PCBs, etc.).", "The receive block 130 includes one or more detectors 132 that may be configured to receive light from an environment of the LIDAR device 104.In one example, a given detector of the detectors 132 is configured and arranged to receive a given light beam of the light beams 124 that is reflected off an object in the environment of the LIDAR device 104 toward the given detector.", "Through this process, for example, the LIDAR device 104 may detect various objects in the environment by emitting light beams 124 using the light sources 122 and detecting reflections of the light beams 124 using the detectors 132.Although not shown, in some examples, the receive block 130 may include additional components such as an inert gas, an entrance aperture (e.g., half-mirror), and/or any other component to filter and/or condition light propagating toward the detectors 132.The detector(s) 132 may comprise photodiodes, avalanche photodiodes, phototransistors, cameras, active pixel sensors (APS), charge coupled devices (CCD), cryogenic detectors, or any other sensor of light.", "In one embodiment, the detector(s) 132 may be configured to detect light at the source wavelength (e.g., 905 nm, etc.)", "of the light beams 124 emitted by the light sources 122 and/or reflections thereof.", "The lens 150 may be optionally included in the LIDAR device 104 and may be configured to collimate the emitted light beams 124 and/or focus light propagating toward the detectors 132.In one embodiment, the lens 150 may be a single lens having an optical power to both collimate the light beams 124 and focus light onto the detectors 132.In another embodiment, the lens 150 may include two separate lenses.", "For example, a first lens may collimate the light beam(s) 124 emitted by the light source(s) 122, and a second lens may focus light propagating toward the LIDAR device 104 onto the detector(s) 132.Other lens configurations are possible as well (e.g., multiple lenses for collimation and/or multiple lenses for focus, etc.).", "In some examples, the LIDAR device 104 may include additional, fewer, or different components than those shown in FIG.", "1.Thus, in some embodiments, the system 100 may be utilized for assembly, manufacture, and/or calibration of various LIDAR devices having various configurations, such as the LIDAR device 104 or any other LIDAR device.", "Accordingly, in some examples, the LIDAR device 104 may be removably mounted to the mounting platform 102 of the system 100 to facilitate such calibration or assembly.", "In some examples, the various components of the LIDAR device 104 such as the transmit block 120, receive block 130, and the lens 150 can be removably mounted in predetermined positions within the LIDAR device 104 to reduce burden of calibrating the arrangement of each component and/or subcomponents included in each component.", "In these examples, the system 100 may adjust the relative position between the transmit block 120 and the receive block 130 to align the one or more light sources 122 with the one or more detectors 132.Alternatively, in other examples, the system 100 may be configured to adjust the relative position between each of the subcomponents (e.g., each light source of light sources 122, each detector of detectors 132, etc.).", "The camera 106 may be any camera (e.g., a still camera, a video camera, etc.)", "configured to capture images of the LIDAR device 104.In some examples, the camera 106 may be located at a given position at which the camera 106 can image the light beams 124 emitted by the one or more light sources 122, and can image the one or more detectors 132.In one embodiment, the camera may be focused at infinity when capturing such images.", "By way of example, the camera may be mounted to have a field-of-view along the path of the light beams 124 (e.g., facing the lens 150, etc.).", "As an example scenario for operation of the camera 106, the LIDAR device 104 may then be configured to cause the light sources 122 to emit the light beams 124 toward the camera 106.In turn, the camera 106 may provide a first image of the light beams 124.The first image, for instance, may indicate light source position(s) (e.g., bright pixels in the first image, etc.)", "of the light source(s) 122.In the scenario, the camera may also obtain a second image indicative of detector position(s) of the detector(s) 132.Other scenarios are possible as well and are described in greater detail within exemplary embodiments herein.", "The light filter 108 may be optionally included in the system 100 to facilitate capture and/or processing of the images described above.", "For instance, the light filter 108 may be positioned along a path of the light beams 124 between the LIDAR device 104 and the camera 106.In one example, the light filter 108 may be configured to attenuate light within a wavelength range that includes the source wavelength of the light source(s) 122.In this example, the attenuation of the light may facilitate contrasting pixels in the first image that are associated with the light beams 124 against surrounding pixels.", "Further, in this example, the attenuation of the light may protect the camera 106 from the intensity of the light beams 124.In another example, the light filter 108 may be configured to attenuate light within another wavelength range that does not include the source wavelength of the light source(s) 122.In this example, the images obtained by the camera 106 may represent features of interest (e.g., light source(s) 122, detector(s) 132, etc.)", "in the LIDAR device 104 more clearly due to the light filter 108 attenuating background light having other wavelengths.", "Other configurations of the light filter 108 are possible as well and are described in greater detail within exemplary embodiments herein.", "The actuator 112 may be optionally included in the system 100.The actuator 112 may be configured to adjust the position of the light filter 108.For instance, the actuator 112 may be configured to actuate the light filter 108 to a first position where the light filter 108 is interposed between the LIDAR device 104 and the camera 106, or to a second position where the light filter 108 is not interposed between the LIDAR device 104 and the camera 106.Example actuators may include motors, stepper motors, pneumatic actuators, hydraulic pistons, relays, solenoids, and piezoelectric actuators among other possibilities.", "The alignment apparatus 160 may include any device that couples to one or more of the components in the LIDAR device 104 to adjust the relative position between the transmit block 120 and the receive block 130.By way of example, the alignment apparatus 160 may be a robotic arm that physically couples to the receive block 130 to rotate and/or translate the position of the receive block 130 in the LIDAR 104.Alternatively or additionally, for example, the robotic arm may adjust the position of the transmit block 120.In some examples, the alignment apparatus 160 may adjust the relative position between the transmit block 120 and the receive block 130 based on image(s) obtained by the camera 106.For instance, the alignment apparatus 160 may adjust the relative position to align one or more of the light beams 124 emitted by the light sources 122 with one or more of the detectors 132.The system 100 may optionally include an auxiliary light source 170 that emits light 174 at the source wavelength to illuminate the receive block 130.The structure and form of the auxiliary light source 170 (e.g., LED, etc.)", "may be similar to the light sources 122.In one example, where the camera 106 is configured to capture images when focused at infinity for the source wavelength the light sources 122, the auxiliary light source 170 may illuminate the detectors 132 to facilitate the camera 106 obtaining the second image of the detectors 132 while also focused at infinity for the same source wavelength.", "In some examples, the light filter 108 may be configured to remain interposed between the camera 106 and the LIDAR device 104 during capture of the first image (e.g., of the light beams 124) and during capture of the second image (e.g., of the detectors 132).", "In these examples, the illuminating light 174 from the auxiliary light source 170 may allow the camera 106 to capture an image of the detectors 132 while the light filter 108 is interposed.", "In other examples, the system 100 may be configured to move the light filter 108 to another position other than the position between the camera 106 and the LIDAR device 104 prior to the camera 106 obtaining the second image of the detectors 132.For instance, the light filter 108 may be moved by the actuator 112.In these examples, the camera 106 may rely on background light to obtain the second image of the detectors 132, or the system 100 may utilize the auxiliary light source 170 to illuminate the receive block 130.The controller 180 may include one or more processors configured to operate some or all of the components of the system 100 in line with the discussion above.", "To that end, the controller 180 may be coupled to the various components via a wired or wireless interface (not shown).", "In some examples, the controller 180 may execute program functions stored in a computer readable medium (not shown) to cause the system 100 to perform various functions and processes of the present method.", "In a first example, the controller 180 may cause a power source (not shown) to provide power to the various components of the system 100.In a second example, the controller 180 may cause the transmit block 120 of the LIDAR device 104 to emit the light beams 124.In a third example, the controller 180 may operate an actuator (not shown) to position the light filter 108 between the LIDAR device 104 and the camera 106, or to position the light filter 108 at any other position.", "In a third example, the controller 180 may operate the camera 106 to obtain the first image (e.g., of the light beams 124) and the second image (e.g., of the detectors 132) in line with the discussion above.", "In a fourth example, the controller 180 may operate the alignment apparatus 160 to adjust the relative position between the transmit block 120 and the receive block 130.In a fifth example, the controller 180 may operate the alignment apparatus 160 to mount (or unmounts) various components (e.g., LIDAR device 104, etc.)", "to the mounting platform 102.In a sixth example, the controller 180 may operate the auxiliary light source 170 to illuminate the receive block 130 with light 174.In a seventh example, the controller 180 may operate the actuator 112 to move the light filter 108.Other examples are possible as well and are described in greater detail within exemplary embodiments herein.", "The system 100 may include additional, fewer, or different components than those shown, and may perform other functions as well.", "In one example, the system 100 may include a display (not shown) for displaying image(s) obtained using the camera 106.For instance, the display may have a graphical user interface (GUI) for displaying and/or interacting with images captured by the camera 106, and a human operator or a computer operator may interact with the GUI to adjust the relative position between the transmit block 120 and the receive block 130 by manipulating the images in the GUI.", "Other procedures are possible as well for controlling the system 100 in accordance with the present disclosure.", "FIG.", "2A illustrates a LIDAR device 200, according to an example embodiment.", "The LIDAR 200 illustrates an example LIDAR device that can be used with a system such as the system 100.For instance, the LIDAR device 200 may be similar to the LIDAR device 104 of the system 100, and may be similarly mounted to the mounting platform 104 to adjust the relative position between light sources and detectors of the LIDAR 200.As shown, the LIDAR device 200 includes a housing 210 and a lens 250.Additionally, light beams 204 emitted by the first LIDAR device 200 propagate from the lens 250 along a viewing direction of the first LIDAR 200 toward an environment of the LIDAR device 200, and reflect off one or more objects in the environment as reflected light 206.The housing 210 included in the LIDAR device 200 can provide a platform for mounting the various components included in the LIDAR device 200.The housing 210 can be formed from any material capable of supporting the various components of the LIDAR device 200 included in an interior space of the housing 210.For example, the housing 210 may be formed from a solid material such as plastic or metal among other possibilities.", "In some examples, the housing 210 can be configured to have a substantially cylindrical shape and to rotate about an axis of the LIDAR device 200.For example, the housing 210 can have the substantially cylindrical shape with a diameter of approximately 10 centimeters.", "In some examples, the axis is substantially vertical.", "By rotating the housing 210 that includes the various components, in some examples, a three-dimensional map of a 360-degree view of the environment of the LIDAR device 200 can be determined without frequent recalibration of the arrangement of the various components of the LIDAR device 200.Additionally or alternatively, in some examples, the LIDAR device 200 can be configured to tilt the axis of rotation of the housing 210 to control the field of view of the LIDAR device 200.The lens 250 mounted to the housing 210 can have an optical power to both collimate the emitted light beams 204, and focus the reflected light 205 from one or more objects in the environment of the LIDAR device 200 onto detectors in the LIDAR device 200.In one example, the lens 250 has a focal length of approximately 120 mm.", "By using the same lens 250 to perform both of these functions, instead of a transmit lens for collimating and a receive lens for focusing, advantages with respect to size, cost, and/or complexity can be provided.", "The LIDAR device 200 can be mounted on a mounting structure 260 that rotates about an axis to provide a 360-degree view of the environment surrounding the LIDAR device 200.In some examples, the mounting structure 260 may comprise a movable platform that may tilt in one or more directions to change the axis of rotation of the LIDAR device 200.FIG.", "2B is a cross-section view of the first LIDAR 200 shown in FIG.", "2A.", "As shown, the housing 210 houses a transmit block 220, a receive block 230, a shared space 240, and the lens 250.For purposes of illustration, FIG.", "2B shows an x-y-z axis, in which the z-axis is in a substantially vertical direction.", "The transmit block 220 includes a plurality of light sources 222a-c arranged along a curved focal surface 228 defined by the lens 250.The plurality of light sources 222a-c can be configured to emit, respectively, the plurality of light beams 202a-c having wavelengths within a wavelength range.", "For example, the plurality of light sources 222a-c may comprise laser diodes that emit the plurality of light beams 202a-c having the wavelengths within the wavelength range.", "The plurality of light beams 202a-c are reflected by mirror 224 through an exit aperture 226 into the shared space 240 and towards the lens 250.The light sources 222a-c can include laser diodes, light emitting diodes (LED), vertical cavity surface emitting lasers (VCSEL), organic light emitting diodes (OLED), polymer light emitting diodes (PLED), light emitting polymers (LEP), liquid crystal displays (LCD), microelectromechanical systems (MEMS), or any other device configured to selectively transmit, reflect, and/or emit light to provide the plurality of emitted light beams 202a-c.", "In some examples, the light sources 222a-c can be configured to emit the emitted light beams 202a-c in a wavelength range that can be detected by detectors 232a-c included in the receive block 230.The wavelength range could, for example, be in the ultraviolet, visible, and/or infrared portions of the electromagnetic spectrum.", "In some examples, the wavelength range can be a narrow wavelength range, such as provided by lasers.", "In one embodiment, the wavelength range includes a source wavelength of 905 nm.", "Additionally, the light sources 222a-c can be configured to emit the emitted light beams 202a-c in the form of pulses.", "In some examples, the plurality of light sources 222a-c can be disposed on one or more substrates (e.g., printed circuit boards (PCB), flexible PCBs, etc.)", "and arranged to emit the plurality of light beams 202a-c towards the exit aperture 226.Although FIG.", "2B shows that the curved focal surface 228 is curved in the x-y plane, additionally or alternatively, the plurality of light sources 222a-c may be arranged along a focal surface that is curved in a vertical plane.", "For example, the curved focal surface 228 can have a curvature in a vertical plane, and the plurality of light sources 222a-c can include additional light sources arranged vertically along the curved focal surface 228 and configured to emit light beams directed at the mirror 224 and reflected through the exit aperture 226.In this example, the detectors 232a-c may also include additional detectors that correspond to additional light sources of the light sources 222a-c. Further, in some examples, the light sources 222a-c may include additional light sources arranged horizontally along the curved focal surface 228.In one embodiment, the light sources 222a-c may include 64 light sources that emit light having a wavelength of 905 nm.", "For instance, the 64 light sources may be arranged in four columns, each comprising 16 light sources, along the curved focal surface 228.In this instance, the detectors 232a-c may include 64 detectors that are arranged similarly (e.g., 4 columns comprising 16 detectors each, etc.)", "along curved focal surface 238.In other embodiments, the light sources 222a-c and the detectors 232a-c may include additional or fewer light sources and/or detectors than those shown in FIG.", "2B.", "Due to the arrangement of the plurality of light sources 222a-c along the curved focal surface 228, the plurality of light beams 202a-c, in some examples, may converge towards the exit aperture 226.Thus, in these examples, the exit aperture 226 may be minimally sized while being capable of accommodating vertical and horizontal extents of the plurality of light beams 202a-c. Additionally, in some examples, the curved focal surface 228 can be defined by the lens 250.For example, the curved focal surface 228 may correspond to a focal surface of the lens 250 due to shape and composition of the lens 250.In this example, the plurality of light sources 222a-c can be arranged along the focal surface defined by the lens 250 at the transmit block.", "The plurality of light beams 202a-c propagate in a transmit path that extends through the transmit block 220, the exit aperture 226, and the shared space 240 towards the lens 250.The lens 250 collimates the plurality of light beams 202a-c to provide collimated light beams 204a-c into an environment of the LIDAR device 200.The collimated light beams 204a-c correspond, respectively, to the plurality of light beams 202a-c.", "In some examples, the collimated light beams 204a-c reflect off one or more objects in the environment of the LIDAR device 200 as reflected light 206.The reflected light 206 may be focused by the lens 250 into the shared space 240 as focused light 208 traveling along a receive path that extends through the shared space 240 onto the receive block 230.For example, the focused light 208 may be reflected by the reflective surface 242 as focused light 208a-c propagating towards the receive block 230.The lens 250 may be capable of both collimating the plurality of light beams 202a-c and focusing the reflected light 206 along the receive path 208 towards the receive block 230 due to the shape and composition of the lens 250.For example, the lens 250 can have an aspheric surface 252 facing outside of the housing 210 and a toroidal surface 254 facing the shared space 240.By using the same lens 250 to perform both of these functions, instead of a transmit lens for collimating and a receive lens for focusing, advantages with respect to size, cost, and/or complexity can be provided.", "The exit aperture 226 is included in a wall 244 that separates the transmit block 220 from the shared space 240.In some examples, the wall 244 can be formed from a transparent material (e.g., glass) that is coated with a reflective material 242.In this example, the exit aperture 226 may correspond to the portion of the wall 244 that is not coated by the reflective material 242.Additionally or alternatively, the exit aperture 226 may comprise a hole or cut-away in the wall 244.The focused light 208 is reflected by the reflective surface 242 and directed towards an entrance aperture 234 of the receive block 230.In some examples, the entrance aperture 234 may comprise a filtering window configured to allow wavelengths in the wavelength range of the plurality of light beams 202a-c (e.g., source wavelength) emitted by the plurality of light sources 222a-c and attenuate other wavelengths.", "In some examples, the entrance aperture 234 may comprise a half-mirror configured to reflect a portion of the focused light 208a-c and allow another portion of the focused light 208a-c to propagate toward the detectors 232a-c.", "The focused light 208a-c reflected by the reflective surface 242 from the focused light 208a-c propagates, respectively, onto a plurality of detectors 232a-c.", "The plurality of detectors 232a-c can be arranged along a curved focal surface 238 of the receive block 230.Although FIG.", "2B shows that the curved focal surface 238 is curved along the x-y plane (horizontal plane), additionally or alternatively, the curved focal surface 238 can be curved in a vertical plane.", "The curvature of the focal surface 238 is also defined by the lens 250.For example, the curved focal surface 238 may correspond to a focal surface of the light projected by the lens 250 along the receive path at the receive block 230.The detectors 232a-c may comprise photodiodes, avalanche photodiodes, phototransistors, cameras, active pixel sensors (APS), charge coupled devices (CCD), cryogenic detectors, or any other sensor of light configured to receive focused light 208a-c having wavelengths in the wavelength range of the emitted light beams 202a-c (e.g., the source wavelength).", "Each of the focused light 208a-c corresponds, respectively, to the emitted light beams 202a-c and is directed onto, respectively, the plurality of detectors 232a-c. For example, the detector 232a is configured and arranged to received focused light 208a that corresponds to collimated light beam 204a reflected of the one or more objects in the environment of the LIDAR device 200.In this example, the collimated light beam 204a corresponds to the light beam 202a emitted by the light source 222a.", "Thus, the detector 232a receives light that was emitted by the light source 222a, the detector 232b receives light that was emitted by the light source 222b, and the detector 232c receives light that was emitted by the light source 222c.", "By comparing the received light 208a-c with the emitted light beams 202a-c, at least one aspect of the one or more object in the environment of the LIDAR device 200 may be determined.", "For example, by comparing a time when the plurality of light beams 202a-c were emitted by the plurality of light sources 222a-c and a time when the plurality of detectors 232a-c received the focused light 208a-c, a distance between the LIDAR device 200 and the one or more object in the environment of the LIDAR device 200 may be determined.", "In some examples, other aspects such as shape, color, material, etc.", "may also be determined.", "In some examples, the LIDAR device 200 may be rotated about an axis to determine a three-dimensional map of the surroundings of the LIDAR device 200.For example, the LIDAR device 200 may be rotated about a substantially vertical axis as illustrated by arrow 290.Although illustrated that the LIDAR device 200 is rotated counter clock-wise about the axis as illustrated by the arrow 290, additionally or alternatively, the LIDAR device 200 may be rotated in the clockwise direction.", "In some examples, the LIDAR device 200 may be rotated 360 degrees about the axis.", "In other examples, the LIDAR device 200 may be rotated back and forth along a portion of the 360 degree view of the LIDAR device 200.For example, the LIDAR device 200 may be mounted on a platform that wobbles back and forth about the axis without making a complete rotation.", "Thus, the arrangement of the light sources 222a-c and the detectors 232a-c may allow the LIDAR device 200 to have a particular vertical field-of-view.", "In one example, the vertical FOV of the LIDAR device 200 is 20°.", "Additionally, the rotation of the LIDAR device 200 allows the LIDAR device 200 to have a 360° horizontal FOV Further, the rate of rotation may allow the device to have a particular refresh rate.", "In one example, the refresh rate is 10 Hz.", "The refresh rate along with the arrangement of the light sources 222a-c and the detectors 232a-c may also allow the LIDAR device 300 to have a particular angular resolution.", "In one example, the angular resolution is 0.2°×0.3°.", "However, the various parameters such as the refresh rate and the angular resolution may vary according to the configuration of the LIDAR device 200.Further, in some examples, the LIDAR device 200 may include additional, fewer, or different components than those shown in FIGS.", "2A-2B.", "FIG.", "2C is a perspective view of the LIDAR device 200 shown in FIG.", "2A with various components removed to illustrate an interior of the LIDAR device 200.As shown, the various components of the LIDAR device 200 can be removably mounted to the housing 210.For example, the transmit block 220 may comprise one or more printed circuit boards (PCBs) that are fitted in the portion of the housing 210 where the transmit block 220 can be mounted.", "Although FIG.", "2C shows the transmit block 220 with one PCB, in some embodiments, the transmit block 320 may include multiple PCBs (not shown) that each include some of the plurality of light sources 232a-c.", "In one embodiment, each PCB in the transmit block may include 16 light sources, and the transmit block 220 may include four PCBs.", "Thus, in this embodiment, the LIDAR device 200 may include 64 light sources.", "Other embodiments are possible as well where the transmit block 220 includes a different number of light sources.", "Additionally, the receive block 230 may comprise a plurality of detectors (e.g., detectors 232a-c, etc.)", "mounted to a flexible substrate and can be removably mounted to the housing 210 as a block that includes the plurality of detectors.", "Similarly, the lens 250 can be mounted to another side of the housing 210.FIG.", "3 illustrates a transmit block 320, according to an example embodiment.", "Transmit block 320 may be similar to the transmit blocks 120 and/or 220 described in FIGS.", "1-2.For example, the transmit block 320 includes a plurality of light sources 322a-c similar to the plurality of light sources 222a-c included in the transmit block 220 of FIGS.", "2A-2C.", "Additionally, the light sources 322a-c are arranged along a focal surface 328, which is curved in a vertical plane.", "The light sources 322a-c are configured to emit a plurality of light beams 302a-c that converge and propagate through an exit aperture 326 in a wall 344.Although the plurality of light sources 322a-c can be arranged along a focal surface 328 that is curved in a vertical plane, additionally or alternatively, the plurality of light sources 322a-c can be arranged along a focal surface that is curved in a horizontal plane or a focal surface that is curved both vertically and horizontally.", "For example, the plurality of light sources 322a-c can be arranged in a curved three dimensional grid pattern.", "For example, the transmit block 320 may comprise a plurality of printed circuit boards (PCBs) vertically mounted such that a column of light sources such as the plurality of light sources 322a-c are along the vertical axis of each PCB and each of the plurality of PCBs can be arranged adjacent to other vertically mounted PCBs along a horizontally curved plane to provide the three dimensional grid pattern.", "Alternatively, in some examples, the light sources 322a-c may be arranged along any other surface such as a linear surface.", "Further, although the transmit block 320 is shown to include multiple light sources 322a-c, in some examples, the transmit block 320 may include only one light source or a different number of light sources than those shown in FIG.", "3.As shown in FIG.", "3, the light beams 302a-c converge towards the exit aperture 326 which allows the size of the exit aperture 326 to be minimized while accommodating vertical and horizontal extents of the light beams 302a-c similarly to the exit aperture 226 described in FIG.", "2B.", "The light emitted by the light sources 222a-c may be partially collimated to fit through the exit aperture 224.FIGS.", "4A, 4B, and 4C illustrate an example of how such partial collimation could be achieved.", "In this example, a light source 400 is made up of a laser diode 402 and a cylindrical lens 404.As shown in FIG.", "4A, laser diode 402 has an aperture 406 with a shorter dimension corresponding to a fast axis 408 and a longer dimension corresponding to a slow axis 410.FIGS.", "4B and 4C show an uncollimated laser beam 412 being emitted from laser diode 402.Laser beam 412 diverges in two directions, one direction defined by fast axis 408 and another, generally orthogonal direction defined by slow axis 410.FIG.", "4B shows the divergence of laser beam 412 along fast axis 408, whereas FIG.", "4C shows the divergence of laser beam 412 along slow axis 410.Laser beam 412 diverges more quickly along fast axis 408 than along slow axis 410.In one specific example, laser diode 402 is an Osram SPL DL90_3 nanostack pulsed laser diode that emits pulses of light with a range of wavelengths from about 896 nm to about 910 nm (a nominal wavelength of 905 nm).", "In this specific example, the aperture has a shorter dimension of about 10 microns, corresponding to its fast axis, and a longer dimension of about 200 microns, corresponding to its slow axis.", "The divergence of the laser beam in this specific example is about 25 degrees along the fast axis and about 11 degrees along the slow axis.", "It is to be understood that this specific example is illustrative only.", "Laser diode 402 could have a different configuration, different aperture sizes, different beam divergences, and/or emit different wavelengths.", "As shown in FIGS.", "4B and 4C, cylindrical lens 404 may be positioned in front of aperture 406 with its cylinder axis 414 generally parallel to slow axis 410 and perpendicular to fast axis 408.In this arrangement, cylindrical lens 404 can pre-collimate laser beam 412 along fast axis 408, resulting in partially collimated laser beam 416.In some examples, this pre-collimation may reduce the divergence along fast axis 408 to about one degree or less.", "Nonetheless, laser beam 416 is only partially collimated because the divergence along slow axis 410 may be largely unchanged by cylindrical lens 404.Thus, whereas uncollimated laser beam 412 emitted by laser diode has a higher divergence along fast axis 408 than along slow axis 410, partially collimated laser beam 416 provided by cylindrical lens 404 may have a higher divergence along slow axis 410 than along fast axis 408.Further, the divergences along slow axis 410 in uncollimated laser beam 412 and in partially collimated laser beam 416 may be substantially equal.", "In one example, cylindrical lens 404 is a microrod lens with a diameter of about 600 microns that is placed about 250 microns in front of aperture 406.The material of the microrod lens could be, for example, fused silica or a borosilicate crown glass, such as Schott BK7.Cylindrical lens 404 could also be used to provide magnification along fast axis 408.For example, if the dimensions of aperture 406 are 10 microns by 200 microns, as previously described, and cylindrical lens 404 is a microrod lens as described above, then cylindrical lens 404 may magnify the shorter dimension (corresponding to fast axis 408) by about 20 times.", "This magnification effectively stretches out the shorter dimension of aperture 406 to about the same as the longer dimension.", "As a result, when light from laser beam 416 is focused, for example, onto a detector, the focused spot could have a substantially square shape instead of the rectangular slit shape of aperture 406.FIG.", "5A illustrates a receive block 530, according to an example embodiment.", "FIG.", "5B illustrates a side view of three detectors 532a-c included in the receive block 530 of FIG.", "5A.", "Receive block 530 may be similar to the receive block 130 of FIG.", "1 and/or the receive block 230 of FIGS.", "2B-2C.", "For example, the receive block 530 includes a plurality of detectors 532a-c arranged along a curved surface 538 defined by a lens 550 similarly to the receive block 230, the detectors 232a-c, and the curved plane 238 described in FIG.", "2B.", "Focused light 508a-c from lens 550 propagates along a receive path that includes a reflective surface 542 onto the detectors 532a-c similar, respectively, to the focused light 208a-c, the lens 250, the reflective surface 242, and the detectors 232a-c described in FIG.", "2B.", "The receive block 530 comprises a flexible substrate 580 on which the plurality of detectors 532a-c are arranged along the curved surface 538.The flexible substrate 580 conforms to the curved surface 538 by being mounted to a receive block housing 590 having the curved surface 538.As illustrated in FIG.", "5B, the curved surface 538 includes the arrangement of the detectors 532a-c curved along a vertical and horizontal axis of the receive block 530.In some embodiments, the number and arrangement of the detectors 532a-c may be different than those shown in FIGS.", "5A-5B.", "For instance, the detectors 532a-c may be alternatively arranged along a linear surface, or may alternatively only include one detector, among other possibilities.", "As noted above in the description of FIG.", "1, the system 100 may be used with various LIDAR devices having various configurations, such as the LIDAR device 200 of FIGS.", "2A-2C.", "FIG.", "6A illustrates another LIDAR device 600 that may be used with the system 100, according to an example embodiment.", "As shown, the LIDAR device 600 includes an optics assembly 610, a transmit lens 652, a receive lens 654, a mirror 620, a pin 622, and a motor 670.For purposes of illustration, FIG.", "6A shows an x-y-z axis, in which the z-axis is pointing out of the page, and the x-axis and y-axis define a horizontal plane along the surface of the page.", "In some examples, the LIDAR device 600 may emit light that propagates away from the mirror 660 along a viewing direction of the LIDAR device 600 (e.g., parallel to z-axis shown in FIG.", "6A, etc.)", "toward an environment of the LIDAR device 600, and may receive reflected light from one or more objects in the environment.", "Accordingly, the optics assembly 610 may be configured to emit light pulses towards the mirror 660 that are then reflected by the mirror 660 towards the environment.", "Further, the optics assembly 610 may be configured to receive reflected light that is reflected off the mirror 660.In one embodiment, the optics assembly 610 may include a single laser emitter that is configured to provide a narrow beam having a wavelength of 905 nm.", "In other embodiments, the optics assembly 610 may include multiple light sources similarly to the LIDAR device 200 of FIGS.", "2A-2C.", "As shown, the optics assembly 610 includes the transmit lens 652 for collimation and/or focusing of emitted light from the optics assembly 610 onto the mirror 620, and a receive lens 654 for focusing reflected light from the mirror 660 onto one or more detectors (not shown) of the optics assembly 610.However, in some examples, the optics assembly 610 may alternatively include a single lens for both collimation of emitted light and focusing of reflected light similarly to the lens 250 of the LIDAR device 200.As shown, the mirror 660 may be arranged to steer emitted light from the transmit lens 652 towards the viewing direction of the LIDAR device 600.Further, for example, the mirror 660 may be arranged to steer reflected light from the mirror 660 towards the receive lens 654.In some examples, the mirror 6690 may be a triangular mirror that performs complete rotations about an axis defined by the pin 662.In one embodiment, the vertical FOV of the LIDAR device 600 is 110°.", "The pin 662 may be configured to mount the mirror 660 to the LIDAR device 600.In turn, the pin 662 can be formed from any material capable of supporting the mirror 660.For example, the pin 662 may be formed from a solid material such as plastic or metal among other possibilities.", "In some examples, the LIDAR device 600 may be configured to rotate the mirror 660 about the pin 662 for complete rotations to steer emitted light from the optics assembly 610 vertically.", "In other examples, the LIDAR device 600 may be configured to rotate the mirror 660 about the pin 662 over a given range of angles to steer the emitted light.", "Thus, in some examples, various vertical FOVs are possible by adjusting the rotation the mirror 660 about the pin 662.The motor 670 may include any motor such as a stepper motor, an electric motor, a combustion motor, a pancake motor, and/or a piezoelectric actuator among other possibilities.", "In some examples, the motor 670 may be configured to rotate various components of the LIDAR device 600 (e.g., optics assembly 610, mirror 660, pin 662, etc.)", "about an axis of the LIDAR device 600.For example, the axis may be substantially vertical similarly to the y-axis shown in FIG.", "6A.", "By rotating the various components of the LIDAR device 600 about the axis, in some examples, the motor 670 may steer the emitted light that is reflected off the mirror 660 horizontally, thus allowing the LIDAR device 600 to have a horizontal FOV.", "In one embodiment, the motor 670 may rotate for a defined amount of rotation such as 270°.", "In this embodiment, the LIDAR device 600 may thus have a horizontal FOV of 270.However, other amounts of rotation are possible as well (e.g., 360°, 8°, etc.)", "thereby allowing a different horizontal FOV for the LIDAR device 600.Thus, in some examples, the LIDAR device 600 may provide an alternative device for scanning the environment or a portion thereof to the LIDAR device 104 of FIG.", "1, and/or the LIDAR device 200 of FIGS.", "2A-2C.", "FIG.", "6B illustrates a partial cross-section view of the LIDAR device 600 shown in FIG.", "6A.", "It is noted that some of the components of the LIDAR device 600 are omitted from the illustration of FIG.", "6B for convenience in description.", "As shown, the optics assembly 610 comprises a transmit block 620 that includes one light source 622.In some examples, the transmit block 620 may alternatively include more than one light source similarly to the transmit block 220 of the LIDAR device 200.However, for the sake of example, the transmit block 620 includes one light source 622.The light source 622 may be configured to emit one or more light pulses (e.g., laser beams, etc.)", "towards the transmit lens 652.For example, as shown, emitted light 602a propagates away from the light source 622 towards the transmit lens 652.In some examples, the light source 622 may be similar to the light sources 222a-c of the LIDAR device 200 of FIGS.", "2A-2C.", "In one embodiment, the light source 622 may be configured to emit light pulses having a wavelength of 905 nm.", "In other embodiments, the light source 622 may be configured to emit light having any other wavelength.", "In line with the discussion above, the transmit lens 652 may be configured to collimate the emitted light 602a into one or more collimated light beams 602b and/or may be configured to focus the emitted light 602a as the focused light 602b onto the mirror 660.As shown, the mirror 660 may be a triangular mirror that has three reflective surfaces 660a, 660b, 660c.", "However, in other examples, the mirror 660 may alternatively include a greater or fewer number of reflective surfaces.", "As shown, the collimated light 602b may then reflect off the reflective surface 602a and into the environment of the LIDAR 600 as emitted light 602c.", "For example, a direction of the emitted light 602c is illustrated by arrow 604.In practice, as the mirror 660 is rotated about an axis defined by the pin 662, the emitted light 602c may be steered to have a different direction than that illustrated by arrow 604.For example, the direction 604 of the emitted light 602c may instead correspond to a different direction along arrow 606.Thus, by rotating the mirror 660 about the pin 662, the LIDAR device 600 may be configured to have a vertical FOV, for example.", "Consider by way of example a scenario where the mirror 660 is configured to rotate about an axis defined by the pin 662 continuously in a clock-wise direction.", "In this scenario, the direction 604 of the emitted light 602c may thereby be adjusted also in a clock-wise direction as illustrated by the arrow 606 until the focused light 602b is reflecting off an edge of the reflective surface 660a.", "At this point, the emitted light 602c would be directed towards a maximum extent of the vertical FOV of the LIDAR device 600.Continuing with the scenario, as the mirror 660 continues to rotate, the collimated light 602b may then be focused onto the reflective surface 660b instead of the reflective surface 660a.", "At this point, the reflected light 602c may be steered to a direction that is towards a minimum extent of the vertical FOV of the LIDAR device 600.Continuing with the scenario, as the mirror 660 continues to rotate, the direction of the emitted light 602c may then be adjusted in a clock-wise direction towards the maximum extent of the vertical FOV that corresponds to the light 602b being focused onto another edge of the reflective surface 660b.", "Similarly, continuing with the scenario, the direction of the emitted light 602c may then be adjusted to scan the vertical FOV of the LIDAR device 600 by reflecting the light 602b off the reflective surface 660c instead of the reflective surface 660b.", "Through this process, for example, the LIDAR device 600 may continuously scan the vertical FOV.", "As a variation of the scenario above by way of example, the mirror 660 may be alternatively configured to rotate within a given range of angles (e.g., wobble, etc.)", "to define a narrower vertical field-of-view than that of the scenario described above.", "Other configurations for rotation of the mirror 660 are possible as well.", "FIG.", "6C illustrates a partial cross-section view of the optics assembly 610 in the LIDAR device 600 of FIG.", "6A.", "For purposes of illustration, FIG.", "6C shows an x-y-z axis, in which the z-axis is pointing out of the page, and the x-axis and y-axis define a horizontal plane along the surface of the page.", "As shown, the optical assembly 610 comprises transmit block 620 that includes one light source 622.The light source 622 may be similar to the light sources 222a-c of the LIDAR device 200.In line with the discussion above, in some examples, the transmit block 620 may alternatively include more than one light source.", "The light source 622 is configured to emit light 602a toward the transmit lens 652.Further, the optical assembly 610 comprises receive block 630 that includes one detector 632.The detector 632 may be similar to the detectors 232a-c of the LIDAR device 200.Again, in some examples, the receive block 630 may alternatively include more than one detector.", "The detector 632 may be configured to receive light 608 focused by the receive lens 654.As shown, the optics assembly 610 also includes an optical shield 612.The optical shield 612 may be configured to provide optical shielding between the transmit block 620 and the receive block 630, at least for the light having the source wavelength of the emitted light 602a.", "In turn, the optical shield 612 may mitigate interference with light 608 detected by the detector 632 of the receive block 630.The optical shield 612 may be formed, for example, as a wall coated by a metal, metallic ink, or metallic foam to provide the shielding.", "Example metals may include copper or nickel.", "Other configurations and/or materials are possible as well for the optical shield 612.As noted in the description of the system 100 of FIG.", "1, in some examples, the present method allows alignment of the detector 632 with light originating at the light source 622.By way of example, an alignment apparatus (e.g., apparatus 160) may couple to the transmit block 620 and/or the receive block 630, and may then adjust the relative position between the transmit block 620 and the receive block 630 to perform the alignment.", "The optical components (i.e., the transmit block 620 and the receive block 630) of the optical assembly 610 may each have six degrees of freedom (DOF).", "Three of the six DOF are translational: forward/backward (e.g., linearly along an axis of the optical component that is parallel to the y-axis shown in FIG.", "6C), up/down (e.g., linearly along an axis of the optical component that is parallel to the z-axis), and left/right (e.g., linearly along an axis of the optical component that is parallel to the x-axis).", "Further, three of the six DOF are rotational: pitch (e.g., rotation about the axis of the optical component that is parallel to the x-axis), yaw (e.g., rotation about the axis of the optical component that is parallel to the z-axis), and roll (e.g., rotation about the axis of the optical component that is parallel to the y-axis).", "In accordance with the present disclosure, the alignment apparatus (not shown) may adjust the relative position between the transmit block 620 and the receive block 630 shown in FIG.", "6C by adjusting some or all of the six DOF described above for one or both of the transmit block 620 and the receive block 630.In line with the discussion above, systems and methods herein allow optics alignment for LIDAR devices having various different configurations.", "Thus, the configurations of the LIDAR devices 200 and 600 are presented for exemplary purposes only.", "Other configurations and LIDAR devices are possible as well for the systems and methods herein.", "FIG.", "7A illustrates a system 700, according to an example embodiment.", "The system 700 may be similar to the system 100 of FIG.", "1.For example, as shown, the system 700 includes a mounting platform 702, a LIDAR device 704, a camera 706, a light filter 708, and an alignment apparatus 760 that can be similar, respectively, to the mounting platform 102, the LIDAR device 104, the camera 106, the light filter 108, and the alignment apparatus 160 of the system 100.As shown, the system 700 also includes a mounting structure 710, an actuator 712, and a manipulator 762.The mounting structure 710 may be formed from any solid material (e.g., metal, plastic, etc.)", "similarly to the mounting platform 702, and may be shaped to facilitate coupling one or more of the components of the system 700 to the mounting platform 702.As shown, for example, the mounting structure 710 couples the camera 706 and the light filter 708 to the mounting platform 702.However, in some examples, a separate mounting structure may be utilized for each of the camera 706 and the light filter 708.The actuator 712 may be configured to adjust a position of the light filter 708.Example actuators may include motors, stepper motors, pneumatic actuators, hydraulic pistons, relays, solenoids, and piezoelectric actuators among other possibilities.", "The manipulator 762 may include any structure configured to couple the alignment apparatus 702 with one or more components of the LIDAR device 704.In line with the discussion above, the system 700 may adjust a relative position between a transmit block (not shown) and a receive block (not shown) of the LIDAR device 704.For instance, the alignment apparatus 760 (e.g., robotic arm, etc.)", "may adjust the relative position between the transmit block and the receive block by adjusting the position of the manipulator 762 or changing the orientation of the manipulator 762, among other possibilities.", "As shown, the mounting platform 702 includes a plurality of holes, exemplified by holes 702a and 702b.", "In some embodiments, the various components such as the LIDAR device 704, the camera 706, and/or the light filter 708 may be mounted to the mounting platform by coupling the various components to such holes in the mounting platform (e.g., by fastening a bolt through the holes).", "In other embodiments, the various components may be mounted to the mounting platform 702 via other processes or devices.", "In one example, the various components may be mounted to the mounting platform 702 via an application of an adhesive among other possibilities.", "In another example, a mounting structure may couple one or more of the components to the mounting platform 702.For instance, as shown in FIG.", "7A, the mounting structure 710 may be coupled to the mounting platform 702 (e.g., by fastening a bolt to one of the holes, etc.", "), and may also be coupled the camera 706 and the light filter 708 to provide the particular positions of the camera 706 and the light filter 708 relative to the mounting platform 702.Other configurations and shapes of the mounting structure 710 are possible as well.", "Further, as shown, the LIDAR device 704 has a configuration similar to the LIDAR device 200 of FIGS.", "2A-2C.", "However, in some examples, other configurations are possible for the LIDAR device 704, such as the configuration of the LIDAR device 600 of FIGS.", "6A-6C among other possibilities.", "An example scenario for operation of the system 700 is as follows.", "First, as shown, the LIDAR device 704 may be mounted to the mounting platform 702 to have a field-of-view (FOV) through which light emitted by a transmit block (not shown) of the LIDAR device 704 and light received by a receive block (not shown) of the LIDAR device 704 propagates.", "For instance, the LIDAR device 704 may be mounted to the mounting platform 702 using the alignment apparatus 760 (e.g., robotic arm, etc.)", "or any other device (e.g., mechanical tool, etc.).", "Next, the camera 706 may be located at a given position relative to the LIDAR device 704 such that the camera 706 may obtain images of the receive block (not shown) of the LIDAR device 704 and/or light emitted by the transmit block (not shown) of the LIDAR device 704.Continuing with the scenario, the camera 706 may then be focused to infinity for the source wavelength (e.g., 905 nm) of the light emitted by the LIDAR device 704.Next, the light filter 708 may be positioned at a first position to be interposed between the LIDAR device 704 and the camera 706 along the FOV of the LIDAR device 704.For instance, the actuator 712 may be configured to move the light filter 708 to the first position shown in FIG.", "7A.", "Continuing with the scenario, the system 700 may then cause the transmit block (not shown) of the LIDAR device 704 to emit one or more light beams through the light filter 708 and toward the camera 706.Referring back to FIG.", "2B by way of example, the light beams may correspond to the light beams 204a-c propagating out of the lens 250.Next, the camera 706 may obtain a first image of the light beams emitted by the LIDAR device 704.Continuing with the example of FIG.", "2B, the first image may indicate light source positions of light sources 222a-c in the LIDAR device 200.At this point in the scenario, the system may then cause the LIDAR device 704 to stop emitting the light beams.", "Continuing with the scenario, the system may then cause the actuator 712 to move the light filter 708 to a second position where the light filter 708 is not interposed between the camera 706 and the LIDAR 704.FIG.", "7B illustrates the light filter 708 at the second position described above.", "In turn, the camera 706 may obtain a second image.", "The second image may indicate detector positions of detectors in a receive block (not shown) of the LIDAR device 704.Referring back to FIG.", "2B by way of example, the second image may represent the detector positions of detectors 232a-c that are viewable to the camera 706 via mirror 242 and lens 250.Continuing with the scenario, the system 700 may then determine at least one offset based on the first image and the second image.", "In one instance, the at least one offset may include distances between adjacent light sources and/or adjacent detectors of the LIDAR device 704.In another instance, the at least one offset may include distances between light beams emitted by light sources in the LIDAR device 704 and corresponding detectors of the LIDAR device 704.Other offsets are possible as well and are described in greater detail within exemplary embodiments herein.", "In line with the discussion above, the alignment apparatus 760 (e.g., robotic arm, etc.)", "may couple to the transmit block (not shown) and/or the receive block (not shown) of the LIDAR device 704 via the manipulator 762.Thus, in the scenario, the alignment apparatus 760 may then adjust the relative position between the transmit block and the receive block in accordance with the determined at least one or more offset.", "FIG.", "7C illustrates a partial view of the system 700 shown in FIGS.", "7A-7B.", "It is noted that some of the components of the system 700 are omitted from the illustration of FIG.", "7C for convenience in description.", "For purposes of illustration, FIG.", "7C shows an x-y-z axis, in which the z-axis is pointing out of the page, and the x-axis and y-axis define a horizontal plane along the surface of the page.", "As shown in FIG.", "7C, the manipulator 762 includes protrusions 762a-d that may be configured to couple with receive block 730.The receive block 730 may be included in the LIDAR device 704 shown in FIGS.", "7A-7B.", "It is noted that other components of the LIDAR device 704 (e.g., transmit block, etc.)", "are omitted from the illustration of FIG.", "7C for convenience in description.", "The receive block 730 may be similar to the receive block 230 of the system 200.However, in some embodiments, the receive block 730 may take any other form such as the configuration of the receive block 630 among other possibilities.", "Similarly to the description of the receive block 630 of FIG.", "6C, the receive block 730 has six degrees of freedom (DOF).", "Three of the six DOF are translational: forward/backward (e.g., linearly along an axis of the receive block 730 that is parallel to the z-axis shown in FIG.", "7C), up/down (e.g., linearly along an axis of the receive block 730 that is parallel to the y-axis), and left/right (e.g., linearly along an axis of the receive block 730 that is parallel to the x-axis).", "Further, three of the six DOF are rotational: pitch (e.g., rotation about the axis of the receive block 730 that is parallel to the x-axis), yaw (e.g., rotation about the axis of the optical component that is parallel to the y-axis), and roll (e.g., rotation about the axis of the optical component that is parallel to the z-axis).", "Continuing with the scenario, the system 700 may adjust the position of the receive block 730, when coupled to the manipulator 762, by adjusting the forward/backward position, the up/down position, the left/right position, the pitch, the yaw, and/or the roll of the receive block 730 in line with the discussion above.", "In turn, the system 700 may adjust the relative position between the transmit block (not shown) of the LIDAR 704 and the receive block 730.In some embodiments, additionally or alternatively to the adjustments to the position/orientation of the receive block 730, the manipulator 762 may adjust the position/orientation of the transmit block (not shown) of the LIDAR device 704 in a similar manner.", "Through this process, for example, the system 700 may align one or more light sources of the LIDAR device 704 with one or more detectors of the LIDAR device 704.In some embodiments, the system 700 may then decouple the manipulator 762 from the receive block 730 (or the transmit block), and the receive block 730 may be configured to remain at the alignment (e.g., relative position) performed by the alignment apparatus 760.By way of example, the system 700 may apply an epoxy or other adhesive to a periphery of the receive block 730 to maintain the receive block 730 at the aligned relative position to the transmit block of the LIDAR device 704.In one instance, the manipulator 762 may remain coupled to the receive block 730 until the adhesive is cured.", "However, other processes are possible as well for maintaining the relative position between the transmit block and the receive block 730 of the LIDAR device 704.For instance, the receive block 730 may be fastened to a housing of the LIDAR device 704 using bolts, screws, or any other device among other possibilities.", "It is noted that the scenario presented above is for exemplary purposes only.", "Other scenarios are possible as well that may include some or all of the components of the system 700, or may include other processes than those described.", "A non-exhaustive list of example variations of the scenario is presented below.", "In a first example, the system 700 may not include the light filter 708.For instance, the camera 706 may be configured to obtain the first image and the second image without the light filter 708 being interposed between the camera 706 and the LIDAR device 704.In a second example, the camera 706 and the light filter 708 may be mounted separately from the LIDAR device 704.For instance, the system 700 may be implemented in an assembly line where multiple LIDAR devices such as the LIDAR device 704 are located on an assembly belt.", "In this instance, the camera 706, the light filter 708 and the robotic arm 760 may be mounted independently adjacent to the assembly belt, and may perform similar functions to the scenario described above to calibrate each LIDAR device in the assembly line.", "In a third example, the receive block 730 may be illuminated by an auxiliary light source (not shown) similar to the auxiliary light source 170.For instance, the light filter 708 may remain interposed between the LIDAR device 704 and the camera 706 while the first image of the laser beams emitted by the LIDAR device 704 is captured by the camera 706, and while the second image of the receive block 730 is captured as well.", "In this instance, the receive block 730 would be visible to the camera 706 through the light filter 708 due to the illumination by the auxiliary light source with light at the source wavelength that is viewable through the light filter 708.In a fourth example, the LIDAR device 704 may be configured to continue emitting light while the camera 106 captures the first image and the second image.", "For instance, the light filter 708 may alternatively attenuate the light beams having the source wavelength emitted by light sources of the LIDAR device 704.Thus, in this instance, the light filter 708 may be positioned as shown in FIG.", "7B while the camera 706 is capturing the first image indicative of the light source positions.", "Further, in this instance, the light filter 708 may be positioned as shown in FIG.", "7A while the camera 706 is capturing the second image indicative of the detector positions.", "Thus, various configurations of the light filter 708 may therefore affect the operation of the system 700 in line with the discussion above.", "In a fifth example, the camera 706 may be configured to capture a single image instead of the first image and the second image.", "The single image may be indicative of both the light source positions of light sources in the LIDAR device 704, and the detector positions of detectors in the receive block 730.Referring back to FIG.", "2B by way of example, the single image may capture both the light beams 204a-c and light reflected off the detectors 232a-c. As in the third example above, the receive block 730 in this example may be illuminated by an auxiliary light source such that the detectors 232a-c are viewable through the light filter 708.Other example scenarios are possible as well.", "FIG.", "8 illustrates another system 800, according to an example embodiment.", "The system 800 may be similar to the systems 100 and 700.For example, the system 800 includes a mounting platform 802, a camera 806, a light filter 808, and an alignment apparatus 860 that are similar, respectively, to the mounting platform 702, the camera 706, the light filter 708, and the alignment apparatus 760 of the system 700.The system 800 also includes a LIDAR device 804 that is similar to the LIDAR device 104 of the system 100.The system 800 also includes a manipulator 862 shaped and configured to couple the alignment apparatus 860 with one or more components of the LIDAR device 804.The system 800 also includes an auxiliary light source 870 that is similar to the auxiliary light source 170 of the system 100.As shown, the LIDAR device 804 has a configuration similar to the LIDAR device 600 of FIGS.", "6A-6C.", "However, in some examples, other configurations are possible as well, such as the configuration of the LIDAR device 200 among other possibilities.", "As shown, the light filter 808 is interposed between the LIDAR device 804 and the camera 806.Additionally, the camera 806 is located at a given position at which the camera 806 can image light beam(s) emitted by the LIDAR device 804 and can image detector(s) (not shown) in the LIDAR device 804.Referring back to FIG.", "6A by way of example, the camera 806 may be positioned to have a field-of-view facing the mirror 660 of the LIDAR device 600.However, as shown, the system 800 does not include an actuator (e.g., actuator 712 of system 700) to move the light filter 808.Instead, the system 800 includes the auxiliary light source 870 to illuminate a receive block (not shown) of the LIDAR device 804 with light having the source wavelength of light emitted by light source(s) (not shown) in the LIDAR device 804.For instance, such illumination may allow detectors in the receive block of the LIDAR device 804 to be viewable by the camera 806 through the light filter 808.Although the auxiliary light source 870 is shown to be mounted separately from other components of the system 800, in some examples, the auxiliary light source 870 may be alternatively mounted to any of the components of the system 800, such as the alignment apparatus 860, the light filter 808, the mounting platform 802, etc.", "In one example, the auxiliary light source 870 may be alternatively mounted inside the LIDAR device 804.Referring back to FIG.", "6C by way of example, the auxiliary light source may be alternatively mounted to a wall of the optics assembly 610.Other configurations of the auxiliary light source 870 are possible as well.", "As shown, the manipulator 862 has a different shape and structure than the manipulator 762 of the system 700.Referring back to FIG.", "6C by way of example, the manipulator 862 may have any shape suitable for adjusting position/orientation of the transmit block 620 and/or the receive block 630.Thus, in some examples, the system 800 may perform similar functions as those described for the system 100 and the system 700, but may include some variations suitable for other LIDAR device configurations, such as the configuration of the LIDAR device 804.FIG.", "9 is a flowchart of a method 900, according to an example embodiment.", "Method 900 shown in FIG.", "9 presents an embodiment of a method that could be used with any of the systems 100, 700, 800, the LIDAR devices 200, 600, the transmit block 320, the light source 400, and/or the receive block 530, for example.", "Method 900 may include one or more operations, functions, or actions as illustrated by one or more of blocks 902-912.Although the blocks are illustrated in a sequential order, these blocks may in some instances be performed in parallel, and/or in a different order than those described herein.", "Also, the various blocks may be combined into fewer blocks, divided into additional blocks, and/or removed based upon the desired implementation.", "In addition, for the method 900 and other processes and methods disclosed herein, the flowchart shows functionality and operation of one possible implementation of present embodiments.", "In this regard, each block may represent a module, a segment, a portion of a manufacturing or operation process, or a portion of program code, which includes one or more instructions executable by a processor for implementing specific logical functions or steps in the process.", "The program code may be stored on any type of computer readable medium, for example, such as a storage device including a disk or hard drive.", "The computer readable medium may include non-transitory computer readable medium, for example, such as computer-readable media that stores data for short periods of time like register memory, processor cache and Random Access Memory (RAM).", "The computer readable medium may also include non-transitory media, such as secondary or persistent long term storage, like read only memory (ROM), optical or magnetic disks, compact-disc read only memory (CD-ROM), for example.", "The computer readable media may also be any other volatile or non-volatile storage systems.", "The computer readable medium may be considered a computer readable storage medium, for example, or a tangible storage device.", "In addition, for the method 900 and other processes and methods disclosed herein, each block in FIG.", "9 may represent circuitry that is wired to perform the specific logical functions in the process.", "At block 902, the method 900 involves mounting a transmit block and a receive block in a light detection and ranging (LIDAR) device to provide a relative position between the transmit block and the receive block.", "The transmit block may include one or more light sources configured to emit light at a source wavelength.", "The receive block may include one or more detectors configured to detect light at the source wavelength.", "In one embodiment, the source wavelength is 905 nm.", "In other embodiments, the source wavelength may be any other wavelength (e.g., infrared, ultraviolet, x-ray, visible, etc.).", "By way of example, the transmit block and the receive block may be mounted by a robotic arm (e.g., alignment apparatuses 160, 760, 860, etc.)", "into a housing (e.g., housing 210, optics assembly 610, etc.)", "to provide the relative position.", "In this example, the relative position may be similar to the relative position between transmit block 220 and receive block 230 of FIG.", "2B, or the relative position between transmit block 620 and receive block 630 of FIG.", "6C, among other possibilities.", "However, in other examples, the mounting at block 902 may be performed by a device other than the alignment apparatus.", "For instance, the mounting at block 902 may correspond to an alignment (e.g., adjustment of the relative position) by a system performing the method 900 for a transmit block and a receive block that are already mounted in a LIDAR device.", "In some examples, the LIDAR device may include a lens configured to (i) collimate light emitted from the one or more light sources and (ii) focus light onto the one or more detectors, similarly to the lens 250 of the LIDAR device 200.In other examples, the LIDAR device may include a transmit lens for collimation of emitted light and a receive lens for focusing received light, similarly to the transmit lens 652 and the receive lens 654 of the LIDAR device 600.At block 904, the method 900 involves locating a camera at a given position at which the camera, when focused at infinity, can image light beams emitted by the one or more light sources and can image the one or more detectors.", "By way of example, the given position may be similar to the position of the camera 706 of the system 700.For instance, a field-of-view of the camera may be aligned with a FOV of the LIDAR device where light emitted from the one or more light sources propagates away from the LIDAR device.", "At block 906, the method 900 involves obtaining a first image indicative of light source positions of the one or more light sources.", "The first image, for example, may be obtained using the camera located at the given position and focused at infinity.", "Referring back to FIG.", "2B by way of example, the light source positions of the light sources 222a-c may vary according to the particular orientation and position of the transmit block 220.In turn, the direction of propagation of the light beams 204a-c may also vary, and such variation may be represented by pixels in the first image obtained by the camera.", "In some examples, the method 900 may also involve obtaining the first image while the one or more light sources are emitting light at the source wavelength.", "For instance, a system performing the method 900 may provide power and/or instructions to the LIDAR device to emit the light at the source wavelength, and may provide instructions to the camera to capture the first image while the one or more light sources are emitting the light.", "Further, in some instances, the system may provide instructions to the camera to adjust the focus to infinity for the source wavelength.", "Alternatively, for instance, the camera may be configured to have the focus prior to capturing the first image.", "In some examples, the method 900 may also involve obtaining the first image while a light filter is interposed between the camera and the one or more light sources.", "The light filter may be similar to the light filters 108, 708, or 808.In one example, the light filter may be configured to attenuate light having wavelengths other than the source wavelength.", "In this example, the first image may be more suitable for representing features of the emitted light beams at the source wavelength.", "In another example, the light filter may be configured to attenuate light within a wavelength range that includes the source wavelength.", "In this example, the light filter may reduce the intensity of the emitted light to protect components of the camera.", "Additionally or alternatively, in this example, the light filter may reduce an amount of light propagating toward the camera that has wavelengths proximal to the source wavelength.", "In turn, for instance, pixels in the first image representing the emitted light beams having the source wavelength may be easily contrasted from surrounding pixels having proximal wavelengths.", "In some examples, the method 900 may also involve detecting a defect in a light source based on the first image.", "In one example, the first image may indicate that one or more of the light sources in the transmit block has a different intensity, brightness, color, or other characteristic compared to other light sources.", "For instance, a system performing method 900 may compare pixel properties (e.g., brightness, intensity, color, etc.)", "associated with one light source against other pixel properties in the first image associated with another light source.", "Alternatively, for instance, the system may compare the pixel properties of the light source with pre-determined pixel properties or pixel properties in a stored image among other possibilities.", "In some examples, the method 900 may also involve detecting an aberration in an optical element optically coupled to a light source based on the first image.", "Referring back to FIGS.", "4A-4C by way of example, the light source may be coupled to an optical element such as the cylindrical lens 404.In this example, the system performing the method 900 may detect the aberration in such optical element by examining the shape or other properties of pixels in the first image that are associated with a light beam from the light source (e.g., compare with other pixels, compare with stored parameters/image, etc.).", "Thus, in some embodiments, the method 900 may allow diagnosis of light source(s) in the LIDAR device.", "At block 908, the method 900 involves obtaining a second image indicative of detector positions of the one or more detectors.", "Similarly to the first image, the second image may be obtained using the camera located at the given position and focused at infinity.", "Referring back to FIG.", "2B by way of example, the second image may represent the detectors 232a-c that are viewable to the camera via the lens 250 and the mirror 242.Referring back to FIGS.", "6A-6C as another example, the second image may represent the detector 632 that is viewable to the camera via the lens 654 and the mirror 660.Thus, in some embodiments, the camera may obtain the first image and the second image while the camera is located at the same given position.", "In some examples, the method 900 may also involve obtaining the second image while the one or more light sources are not emitting light at the source wavelength.", "For instance, a system performing the method 900 may reduce power to the one or more light sources and/or provide instructions to the LIDAR device to stop emitting light beams.", "However, in other examples, the method 900 may involve obtaining the second image while the one or more light sources are emitting the light at the source wavelength.", "In one instance, a light filter may be interposed between the camera and the LIDAR device while the camera is capturing the second image, and the light filter may be configured to attenuate light at the source wavelength emitted by the one or more light sources.", "In this instance, the system performing the method 900 may then obtain the second image indicative of the detector positions while the light filter attenuates the light beams emitted by the one or more light sources.", "In another instance, the second image may indicate both the light source positions and the detector positions since the one or more light sources are emitting the light at the source wavelength when the second image is obtained.", "Other examples are possible as well.", "In some examples, the method 900 may also involve obtaining the second image while the one or more detectors are illuminated with light at the source wavelength from an auxiliary light source.", "The auxiliary light source may be similar to the auxiliary light sources 170 and 870 included, respectively, in the systems 100 and 800.In one example, the camera may be focused at infinity for the source wavelength.", "In another example, a light filter interposed between the camera and the LIDAR device may be configured to attenuate light having wavelengths other than the source wavelength.", "In both examples, the auxiliary light source may illuminate the one or more detectors such that reflections of the illuminating light having the source wavelength are viewable by the camera when capturing the second image.", "At block 910, the method 900 involves determining at least one offset based on the light source positions indicated by the first image and the detector positions indicated by the second image.", "In one example, the at least one offset may include distances between adjacent regions of the first image that are associated with particular light sources.", "In another example, the at least one offset may include distances between adjacent regions of the second image that are associated with particular detectors.", "In yet another example, the at least one offset may include an offset between a region of the first image associated with a given light source, and a corresponding region of the second image associated with a given detector.", "The offset in the third example may have a horizontal component and a vertical component, or may just be a distance between the respective regions (e.g., number of pixels).", "As a variation of the third example, the offset may also include a depth component where the camera is configured to obtain 3D images, for instance.", "Other offsets are possible as well.", "In some examples, the method 900 may also involve generating a composite image based on overlaying the first image and the second image.", "In these examples, the at least one offset may be determined based on separation between one or more pixels in the composite image associated with a light source and one or more pixels in the composite image associated with a corresponding detector.", "At block 912, the method 900 includes adjusting a relative position between the transmit block and the receive block based at least in part on the at least one offset.", "By way of example, a robotic arm or other device (e.g., alignment apparatuses 160, 760, 860, etc.)", "may couple to the transmit block and/or the receive block to adjust the relative position.", "The robotic arm, for instance, may translate the coupled component linearly and/or rotate the coupled component about an axis in line with the discussion for the systems 100, 700, and 800.Accordingly, in some examples, the method 900 may also involve adjusting the relative position between the transmit block and the receive block by rotating the receive block about an axis.", "Further, in some examples, the method 900 may also involve adjusting the relative position by rotating the transmit block about an axis.", "In some examples, adjusting the relative position between the transmit block and the receive block at block 912 reduces the at least one offset.", "For instance, where the at least one offset includes an offset between a light source and a corresponding detector, the adjustment of the relative position may reduce the offset to align the light source with the detector.", "In other examples, adjusting the relative position between the transmit block and the receive block at 912 causes the at least one offset to correspond to a particular offset.", "For instance, where the at least one offset includes an offset between two adjacent light sources, the adjustment of the relative position may cause the offset to correspond to the particular offset.", "FIG.", "10 illustrates an image 1000 indicative of light source positions of light sources in a transmit block of a LIDAR device, according to an example embodiment.", "The image 1000 may be similar to the first image described at block 906 of the method 900.For instance, dark pixels in the image 1000 may represent light beams emitted by one or more light sources in a transmit block.", "Referring back to FIG.", "3 by way of example, each of regions 1002, 1004, 1006 in the image 1000 may correspond, respectively, to light beams 302a, 302b, 302c emitted by light sources 322a, 322b, 322c of the transmit block 320.FIG.", "11 illustrates an image 1100 indicative of detector positions of detectors in a receive block, according to an example embodiment.", "The image 1100 may be similar to the second image described at block 908 of the method 900.Referring back to FIG.", "5A by way of example, regions 1102, 1104, 1106 in the image 1100 may correspond, respectively, to the detectors 532a, 532b, 532c of the receive block 530.FIG.", "12 illustrates an image 1200 in a scenario where light sources in a transmit block and detectors in a receive block of a LIDAR device are aligned, according to an example embodiment.", "For example, the image 1200 may correspond to a composite image generated by overlaying the image 1000 and the image 1100, in line with the discussion at block 910 of the method 900.However, in some examples, light sources and detectors in a LIDAR device may not be aligned with one another due to manufacturing/assembly variability or other factors.", "FIG.", "13 illustrates an image 1300 in a scenario where the light sources and the detectors of a LIDAR device are misaligned along the up/down DOF described in the discussion of FIG.", "7C, according to an example embodiment.", "Image 1300 may be a composite image determined similarly to the image 1200.For instance, region 1302 may correspond to region 1006 of the image 1000, and region 1304 may correspond to region 1106 of the image 1100.In turn, the at least one offset determined at block 910 of the method 900 may correspond to a distance (e.g., pixel distance, etc.)", "between the region 1302 and the region 1304, and a system (e.g., system 700, etc.)", "may perform the adjustment of the relative position between the transmit block and the receive block to align the light source associated with region 1302 with the detector associated with region 1304.By way of example, the system may adjust the up/down position of the transmit block and/or the up/down position of the receive block to reduce the determined offset, in line with the discussion above.", "FIG.", "14 illustrates an image 1400 in a scenario where the light sources and the detectors of the LIDAR device are misaligned along the left/right DOF described in the discussion of FIG.", "7C, according to an example embodiment.", "As a variation of the discussion for image 1300, an offset in the LIDAR device of image 1400 may correspond to the distance between the regions 1402 (e.g., associated with a light source) and 1404 (e.g., associated with a corresponding detector).", "FIG.", "15 illustrates an image 1500 in a scenario where the light sources and the detectors are misaligned along the forward/backward DOF, according to an example embodiment.", "For instance, as shown in image 1500, the regions that correspond to light source positions appear smaller and closer to one another, than the regions that correspond to detector positions.", "Similarly here, one or more offsets according to block 910 of the method 900 may be determined.", "An example offset may be a ratio between: (i) the distance between region 1502 and 1504 (e.g., particular detector positions), and (ii) the distance between regions 1506 and 1508 (e.g., corresponding light source positions).", "However, other offsets are possible as well such as offsets determined by various image processing algorithms to detect differences in sizing or depth among other possibilities.", "FIG.", "16 illustrates an image 1600 in a scenario where the light sources and the detectors are misaligned along the roll DOF described in FIG.", "7C, according to an example embodiment.", "Similarly here, the offset between the roll position of the light sources and the roll position of the detectors may be determined.", "For instance, an image processing algorithm may determine such offset, and a system of the present method may adjust the relative position between the transmit block and the receive block accordingly.", "Alternatively, for instance, manual operation of a robotic arm may be employed by visual inspection of the image 1600 (e.g., video feed, etc.)", "to adjust the relative position between the transmit block and the receive block, among other possibilities.", "FIG.", "17 illustrates an image 1700 in a scenario where the light sources and detectors are misaligned along the yaw DOF described in FIG.", "7C, according to an example embodiment.", "For instance, as shown, light beams from light sources at a right side of the image 1700 (e.g., associated with regions 1702 and 1704) are at a greater distance (e.g., offset) to one another than light sources at a left side of the image 1700 (e.g., associated with regions 1706 and 1708).", "This variation may be due to the yaw of the transmit block.", "In contrast, distances between adjacent corresponding detectors (e.g., associated with regions 1710 and 1712) do not exhibit the same variation, due to the receive block having a different yaw.", "Thus, in some examples, the present method may adjust the yaw of the receive block to correspond to the yaw of the transmit block.", "Alternatively or additionally, in some examples, the present method may adjust the yaw of the transmit block to correspond to the yaw of the receive block.", "FIG.", "18 illustrates an image 1800 in a scenario where the light sources and detectors are misaligned along the pitch DOF described in FIG.", "7C, according to an example embodiment.", "Similarly to the discussion above for the yaw misalignment in image 1700, the transmit block in this scenario has a pitch orientation that is different from the pitch orientation of the receive block.", "For instance, a distance (e.g., offset) between light beams indicated by regions 1802 and 1804 is different from the distance between light beams indicated by regions 1806 and 1808, due to the pitch of the transmit block.", "Further, corresponding detectors for those light beams are not similarly separated in the image 1800, which indicates that the receive block has a different pitch than the pitch of the transmit block.", "In turn, similarly to the discussion above for image 1700, the present method may adjust the pitch of the transmit block, the receive block, or both, to align the transmit block with the receive block, in line with the discussion at block 912 of the method 900.Although images 1200-1800 illustrate composite images overlaying a first image (e.g., image 1000, etc.)", "with a second image (e.g., image 1100), in some examples, the present method may determine the various offsets described above for images 1200-1800 without overlaying the two images.", "For instance, a computing device herein may determine the various offsets by comparing pixel locations in the first image 1000 with corresponding pixel locations in the second image 1100.Other image processing techniques are possible as well (e.g., filtering, transforms, etc.)", "for determining the at least one offset described at block 910 of the method 900.Further, although images 1300-1800 illustrate scenarios where the light sources and the detectors are offset in only one DOF, in some examples, the light sources and the detectors may be offset in more than one DOF.", "For instance, a LIDAR device may have light sources and detectors that are offset in both the forward/backward DOF described in image 1500 and the roll DOF described in image 1600.Other offset combinations are possible as well.", "Further, although images 1000-1800 represent light sources and detectors of a LIDAR device having a similar configuration to the LIDAR device 200, in some examples, similar images may be generated for any other LIDAR device configuration, such as the configuration of the LIDAR device 600 among other possibilities.", "In addition to alignment of light sources and detectors of a LIDAR device, in some examples, the present method may facilitate diagnosis of the various components of the LIDAR device.", "As an example, FIG.", "19 illustrates an image 1900 indicative of a defect or an aberration.", "Image 1900 is an example image of light beams from a transmit block, similarly to the image 1000.For instance, region 1902 of image 1900 may correspond to a light beam from a light source, similarly to region 1002 of the image 1000.In one example, region 1904 may represent a light beam from a defective light source.", "For instance, pixels in region 1904 may have a different color, brightness, intensity, or any other characteristic than pixels in other similar regions (e.g., region 1902), due to a defect in the light source associated with region 1904.In another example, region 1906 may be a region where a light beam from a light source is expected, and therefore the associated light source may also be defective.", "In yet another example, regions 1908 and 1910 appear distorted compared to similar regions (e.g., region 1902).", "In turn, for instance, such distortions may indicate that optical elements (e.g., cylindrical lens 404 of FIGS.", "4B-4C, etc.)", "coupled to light sources associated with regions 1908 and 1910 may have aberrations, and the present method may therefore detect the aberrations.", "Other example defects and aberrations are possible as well.", "In some examples, the present method may detect the various defects/aberrations described above by comparing the various regions 1904-1910 with similar regions in the image 1900 (e.g., region 1902, etc.).", "Additionally or alternatively, in some examples, the present method may detect the various defects/aberrations by comparing the image 1900 with a stored image (e.g., image 1000).", "FIG.", "20 is a flowchart of another method 2000, according to an example embodiment.", "Method 2000 shown in FIG.", "20 presents an embodiment of a method that could be used with any of the systems 100, 700, 800, the LIDAR devices 104, 200, 600, 704, 804, the transmit block 320, the light source 400, and/or the receive block 530, for example.", "Method 2000 may include one or more operations, functions, or actions as illustrated by one or more of blocks 2002-2004.Although the blocks are illustrated in a sequential order, these blocks may in some instances be performed in parallel, and/or in a different order than those described herein.", "Also, the various blocks may be combined into fewer blocks, divided into additional blocks, and/or removed based upon the desired implementation.", "At block 2002, the method 2000 involves obtaining one or more images using a camera located at a given position at which the camera can image light beams emitted by one or more light sources in a transmit block of a LIDAR device and can image one or more detectors in a receive block of the LIDAR device.", "In some examples, the one or more images may include a single image that indicates both light source positions of the one or more light sources and detector positions of the one or more detectors.", "For instance, the single image may be similar to images 1200-1800 shown in FIGS.", "12-18.In other examples, the one or more images may include a first image indicative of the light source positions and a second image indicative of the detector positions, similarly to the first image and the second image described, respectively, at blocks 906 and 908 of the method 900.In some examples, the method 2000 may also involve causing an actuator to move a light filter to a first position where the light filter is interposed between the camera and the LIDAR device, obtaining a first image indicative of light source positions of the one or more light sources while the light filter is at the first position, causing the actuator to move the light filter to a second position where the light filter is outside a field-of-view of the camera, and obtaining a second image indicative of detector positions of the one or more detectors while the light filter is at the second position.", "Referring back to FIGS.", "7A and 7B by way of example, the actuator, the light filter, and the camera may correspond, respectively, to the actuator 712, the light filter 708, and the camera 706.Thus, in this example, the method 2000 may adjust the position of the light filter 708 to the first position illustrated in FIG.", "7A to obtain the first image, and to the second position illustrated in FIG.", "7B to obtain the second image.", "At block 2004, the method 2000 involves adjusting a relative position between the transmit block and the receive block based on the one or more images.", "For instance, the adjustment at block 2004 may be similar to the adjustments described at block 912 of the method 900, along some or all the six DOF (e.g., up/down, left/right, forward/backward, roll, yaw, pitch) of the transmit block, the receive block, or both.", "Through this process, for instance, the present method may align the one or more light sources with the one or more detectors.", "In some scenarios, the process described for yaw or pitch alignment in the description of images 1700 and 1800 is less suitable than other methods herein.", "As an example, the variation in distances between adjacent light sources indicated by a first image (e.g., image 1000) and the variation in distances between adjacent detectors indicated by a second image (e.g., image 1100) may be insufficient for detection of yaw or pitch offsets between the transmit block and the receive block.", "For instance, the one or more detectors (or the one or more light sources) may be arranged closely to one another.", "As another example, the transmit block and the receive block may only include, respectively, one light source and one detector, similarly to the transmit block 620 and the receive block 630 shown in FIG.", "6C.", "Thus, in this example, there may be no adjacent light sources or adjacent detectors for the determination of the offsets described in the description of images 1700 and 1800.Accordingly, in some embodiments, alternative or additional processes for rotational position alignment (e.g., yaw, pitch, roll) are presented below.", "In one embodiment, the receive block may be coupled to a half-mirror positioned along a receive path of the receive block.", "Referring back to FIG.", "2B by way of example, the half-mirror may correspond to the entrance aperture 234 and may be configured to reflect at least a portion of light incident on the half-mirror, and the receive path may correspond to receive path 208.Further, in this embodiment, the camera may be coupled to at least two light sources positioned along a periphery of a camera lens of the camera.", "The at least two light sources may be configured to emit light toward the LIDAR device.", "Further, in this embodiment, the method 2000 may also involve causing the at least two light sources to emit light pulses, and obtaining a third image from the camera indicative of reflections of the emitted light pulses off the half-mirror.", "In one instance, the method 2000 may also involve determining offsets between the reflections indicated by the third image, and determining the rotational position adjustment accordingly.", "In another instance, the method 2000 may alternatively involve comparing the third image with a stored image, and adjusting the relative position based on the comparison.", "For example, the stored image may indicate particular pre-determined offsets between the reflected light pulses that correspond to a particular yaw, pitch, or roll of the receive block.", "In this example, the method 2000 may adjust the relative position to achieve the particular offsets.", "In another embodiment, the method 2000 may additionally or alternatively involve actuating at least two probes adjacent to the receive block toward the receive block.", "A given probe (e.g., force sensor, proximity sensor, etc.)", "may be configured to provide a signal indicative of contact (or proximity) between the given probe and the receive block.", "In this embodiment, adjusting the relative position may comprise rotating the receive block (e.g., adjusting yaw, pitch, or roll of the receive block) such that at least two signals from the at least two probes are provided at a substantially same time.", "For instance, the at least two probes may have a particular yaw or pitch substantially similar to the yaw or pitch of the transmit block, and thus by providing the at least two signals at the substantially same time, the yaw or pitch of the receive block may also correspond to the yaw or pitch of the transmit block.", "FIG.", "21 illustrates a partial cross-section view of yet another system 2100, according to an example embodiment.", "The system 2100 may be similar to any of the systems 100, 700, or 800.For instance, as shown, the system 2100 includes a LIDAR device 2104 that is similar to the LIDAR devices 104 and 704 the systems 100 and 700.It is noted that some components of the system 2100 (e.g., alignment apparatus, mounting platform, etc.)", "are omitted from the illustration of FIG.", "21 for convenience in description.", "As shown, the LIDAR device 2104 has a configuration similar to the LIDAR device 200.For instance, as shown, the LIDAR device 2104 includes a transmit block 2120, light sources 2122a-c, receive block 2130, detectors 2132a-c, an exit aperture 2134, and a lens 2150 that are similar, respectively, to the transmit block 220, the light sources 222a-c, the receive block 230, the detectors 232a-c, the exit aperture 234, and the lens 250 of the LIDAR device 200.However, in some examples, the system 2100 may be adapted for use with other LIDAR device configurations such as the configuration of the LIDAR device 600, etc.", "Further, as shown, the system 2100 includes an actuator 2190 and probes 2192-2194.The actuator 2190 may be configured to move the probes 2192 and 2194 toward the receive block 2130 in line with the discussion above at block 2004 of the method 2000.Example actuators may include motors, pneumatic actuators, hydraulic pistons, relays, solenoids, and piezoelectric actuators among other possibilities.", "The probes 2192 and 2194 may include any probes suitable for detection of the receive block 2130 in line with the discussion above at block 2004 of the method 2000.In one example, the probes 2192-2194 may include force sensors that provide a signal if the probes 2192-2194 contact the receive block 2130.In another example, the probes 2192-2194 may include proximity sensors (e.g., IR range sensors, etc.)", "that provide a signal if the probes 2192-2194 are within a threshold distance to the receive block 2130.In the illustration of FIG.", "21, a yaw of a component corresponds to an amount of rotation of the component about an axis of the component pointing out of the page.", "Further, a pitch of the component corresponds to an amount of rotation of the component about an axis of the component pointing away from the component.", "For instance, a pitch of the transmit block 2120 may be the amount of rotation of the transmit block 2120 about an axis perpendicular to one of the light sources 2122a-c, a pitch of the receive block 2130 may be the amount of rotation of the receive block 2130 about an axis perpendicular to the exit aperture 2134, and a pitch of the probe 2192 may be the amount of rotation of the probe 2192 about an axis perpendicular to the probe 2192 that is pointing toward the receive block 2130, etc.", "In line with the discussion above, the system 2100 provides an example embodiment for the rotational position alignment described at block 2004 of the method 2000.Consider an example scenario where the probes 2192-2194 have a particular yaw (i.e., amount of rotation about axis pointing out of page) as shown in FIG.", "21.In some examples, the particular yaw may be substantially similar to the yaw of the transmit block 2120.In one example, the probes 2192-2194 may be mounted via a mounting apparatus (not shown) to the transmit block 2120.In this example, the mounting apparatus may have a particular structure that causes the probes 2192-2194 to have a substantially similar yaw to the yaw of the transmit block 2120.In another example, the probes 2192-2194 may be mounted to an alignment apparatus (e.g., alignment apparatus 160, 760, 860, etc.)", "that provides the particular yaw.", "For instance, the system 2100 may determine the yaw of the transmit block 2120 by processing an image from a camera (not shown) in line with the description of the image 1700 of FIG.", "17.In turn, for instance, the system 2100 may adjust the particular yaw of the probes 2192-2194 by utilizing a robotic arm or other device coupled to the probes 2192-2194 among other possibilities.", "Continuing with the example scenario, the actuator 2190 may move the probes 2192-2194 toward the receive block 2130 in line with the discussion at block 2004 of the method 2000.On one hand, if the two probes 2192-2194 detect the receive block 2130 (e.g., provide a signal, etc.)", "at a substantially similar time, then the system 2100 may determine that the yaw of the receive block 2130 corresponds to the yaw of the probes 2192-2192, and therefore also corresponds to the yaw of the transmit block 2120.On the other hand, if the two probes 2192-2194 detect the receive block 2130 at substantially different times, then the system 2100 may determine that the yaw of the receive block 2130 does not correspond to the yaw of the probes 2192-2194, and therefore does not correspond to the yaw of the transmit block 2120.In this case, the system 2100 may then perform the adjustment of the relative position between the transmit block 2120 and the receive block 2130 in line with the discussion at block 912 of the method 900.Through this process, for example, the transmit block 2120 and the receive block 2130 may be aligned with one another, at least with regard to the yaw DOF.", "As a variation of the example scenario, the probes 2192-2194 may be arranged vertically (e.g., along an axis pointing out of the page) instead of the arrangement shown in FIG.", "21, or the system 2100 may include two additional probes (not shown) that are arranged vertically.", "In either case, the probes in this scenario may have a particular pitch (e.g., amount of rotation about an axis pointing away from the probes 2192-2194 toward the receive block 2130).", "Similarly to the previous scenario, the particular pitch may also correspond to a pitch of the transmit block 2120.Thus, in this scenario, a similar process to the previous scenario may be performed by the system 2100 to align the pitch of the receive block 2130 with the pitch of the transmit block 2120.As a further variation of the example scenarios above, the probes 2192-2194 may be alternatively moved by the actuator 2192 toward the transmit block 2120 instead of the receive block 2130.In this scenario, the system 2100 may adjust the position of the transmit block 2120 to align the pitch and/or yaw of the transmit block 2120 with the pitch and/or yaw of the receive block 2130.FIG.", "22 illustrates a front-view of a camera 2206, according to an example embodiment.", "The camera 2206 may be similar to the cameras 106, 706, and 806 included, respectively, in the systems 100, 700, and 800.For instance, the camera 2206 may be located at a given position where the camera can capture images of light beams emitted by a LIDAR device and can capture images of detectors in the LIDAR device, similarly to the cameras 106, 706, and 806.However, in some examples, the camera 2206 may be located in other positions such as inside the housing of a LIDAR device, similarly to the probes 2192-2194 of the system 2100.In these examples, the camera 2206 may be configured to only capture images of the detectors in the LIDAR device, or may be configured to only capture images of light beams emitted by the LIDAR device, among other possibilities.", "As shown, the camera 2206 includes a lens 2210 and light sources 2212, 2214, 2216, and 2218.However, in some examples, the camera 2206 may include additional, fewer, or different components than those shown.", "In one example, the camera 2206 may alternatively not include the lens 2210.For instance, the camera 2206 in this example may be an image sensor configured to capture images without use of the lens 2210, among other possibilities.", "In another example, the camera 2206 may be alternatively configured not to include the light sources 2212-2218, or may be configured to include additional or fewer light sources than the four light sources 2212-2218 shown, in accordance with the discussion at block 2004 of the method 2000.The lens 2210 may include one or more optical element (e.g., convex lens, concave lens, Fresnel lens, mirror, etc.)", "arranged to modify, condition, focus, and/or redirect light incident on the lens 2210 toward imaging sensors (not shown) of the camera 2206.In some examples, the lens 2210 may be configured to provide an infinity focus for incident light having a source wavelength.", "In one embodiment, the source wavelength is 905 nm.", "However, other source wavelengths are possible as well (e.g., infrared, ultraviolet, x-ray, visible, etc.).", "The light sources 2212-2218 may include laser diodes, light emitting diodes (LEDs), vertical cavity surface emitting lasers (VCSEL), organic light emitting diodes (OLEDs), polymer light emitting diodes (PLED), light emitting polymers (LEP), liquid crystal displays (LCD), microelectromechanical systems (MEMS), filament light sources, or any other device configured to selectively transmit, reflect, and/or emit light propagating away from the camera 2206.In some examples, the light sources 2212-2218 may be configured to emit light at the source wavelength of light emitted by the LIDAR device (not shown) imaged by the camera 2206.Referring back to FIG.", "7A by way of example, the camera 2206 may correspond to the camera 706 of the system 700.Thus, in this example, the light sources 2212-2218 may emit light having the source wavelength that can propagate through the light filter 708 similarly to light emitted by the LIDAR device 704.However, in other examples, the light sources 2212-2218 may be configured to emit light at other wavelengths.", "For instance, the light filter may allow propagation of the light from the light sources 2212-2218 even if the light has other wavelengths, or the light filter may not be interposed between the camera 2206 and the LIDAR device, similarly to the configuration shown in FIG.", "7B, among other possibilities.", "As shown, the light sources 2212-2218 are positioned along a periphery of the camera lens 2210.However, in some examples, the light sources 2212-2218 may be alternatively positioned at a different location.", "In one example, referring back to FIG.", "7A, the light sources 2212-2218 may be alternatively positioned along a periphery of the light filter 708.In another example, referring back to FIG.", "21, the light sources 2212-2214 may be alternatively positioned within a housing of the LIDAR device 2104 similarly to the probes 2192-2194.As a variation of the previous example, the camera 2206 may be alternatively positioned inside the housing of the LIDAR device 2104 as well similarly to the actuator 2190.In yet another example, referring back to FIG.", "21, the light sources 2212-2218 may be alternatively positioned at a periphery of the transmit block 2120 or at a periphery of the receive block 2130.Other positions for the light sources 2212-2218 are possible as well.", "Thus, in some examples, the light sources 2212-2218 may be utilized by a system of the present method to determine the at least one offset in line with the discussion at block 910 of the method 900, and therefore facilitate the adjustment of the relative position between a transmit block and a receive block of a LIDAR device in line with the discussion at block 912 of the method 900.In one example, the light sources 2212-2218 may facilitate alignment of the rotational position (e.g., yaw, pitch, roll) of a transmit block and a receive block in line with the discussion at block 2004 of the method 2000.As an example scenario for rotational position alignment using the camera 2206, suppose that the camera 2206 corresponds to the camera 706 of the system 700.In the scenario, the light sources 2212-2218 may be configured to emit light that propagates through the light filter 708 (e.g., if the light filter 708 is interposed between the camera 2206 and the LIDAR device 704 as illustrated in FIG.", "7A).", "Suppose that, for the sake of example, the LIDAR device 704 has the configuration of the LIDAR device 200 shown in FIG.", "2B.", "In this example, the light from the light sources 2212-2218 may propagate through the lens 250, and then reflect off mirror 242 onto the entrance aperture 234.Further, suppose that, in this example, the entrance aperture 234 includes a half-mirror that reflects at least a portion of the light from the light sources 2212-2218.In turn, the reflected light may reflect off the half-mirror, then reflect off the mirror 242, then propagate through the lens 250 of the LIDAR device, and then propagate into the lens 2210 of the camera 2206.At this point in the scenario, the camera 2206 may capture an image of the reflected light in line with the discussion at block 2004 of the method 2000.Continuing with the scenario, a system of the present method may then analyze the image, in line with the discussion for images 1700-1800, using the properties (e.g., position, shape, intensity, etc.)", "of the light beams originating from the light sources 2212-2218 to determine yaw or pitch offsets between the transmit block and the receive block.", "As a variation of the scenario above, suppose that the light sources 2212-2218 are alternatively positioned along a periphery of the transmit block 220 of the LIDAR device 200.In this scenario, four mirrors may be positioned at the positions shown for the light sources 2212-2218.In turn, the four mirrors may reflect the light from the light sources 2212-2218 towards the receive block 230 of the LIDAR device 200, and the camera 2206 may capture an image of reflections of that light off the entrance aperture 234 (e.g., half-mirror) to determine a possible yaw/pitch offset between the transmit block 220 and the receive block 230.As another variation of the scenario, suppose that the light sources 2212-2218 are alternatively positioned along a periphery of the receive block 230 of the LIDAR device 200.In this scenario, a system of the present method may analyze an image of light from the light sources 2212-2218 in line with the discussion for images 1600-1800 to determine the rotational position (e.g., roll, yaw, pitch) of the receive block.", "As yet another variation of the scenario, the light sources 2212-2218 may be alternatively positioned along a periphery of the transmit block 220 of the LIDAR device 200, and four additional similar light sources may be positioned along the periphery of the receive block 230 of the LIDAR device 200.Similarly here, one or more images of the light from the light sources 2212-2218 and the four additional light sources may be obtained from the camera 2206 and analyzed by the system of the present method to determine rotational offsets (e.g., roll, yaw, pitch) between the transmit block and the receive block.", "Thus, various configurations and positions are possible for the light sources 2212-2218 to facilitate optics alignment in line with the discussion above.", "It should be understood that arrangements described herein are for purposes of example only.", "As such, those skilled in the art will appreciate that other arrangements and other elements (e.g.", "machines, interfaces, functions, orders, and groupings of functions, etc.)", "can be used instead, and some elements may be omitted altogether according to the desired results.", "Further, many of the elements that are described are functional entities that may be implemented as discrete or distributed components or in conjunction with other components, in any suitable combination and location, or other structural elements described as independent structures may be combined.", "While various aspects and embodiments have been disclosed herein, other aspects and embodiments will be apparent to those skilled in the art.", "The various aspects and embodiments disclosed herein are for purposes of illustration and are not intended to be limiting, with the true scope being indicated by the following claims, along with the full scope of equivalents to which such claims are entitled.", "It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting." ] ]
Patent_15876129
[ [ "SEMICONDUCTOR DEVICE", "A logic circuit in a system LSI is provided with a power switch so as to cut off the switch at the time of standby, reducing leakage current.", "At the same time, an SRAM circuit of the system LSI controls a substrate bias to reduce leakage current." ], [ "1-15.", "(canceled) 16.A semiconductor device comprising: a first line for a first voltage; a second line for a second voltage lower than the first voltage; a first P channel MOS transistor having a gate coupled to receive a first control signal and having a source-drain path; a second P channel MOS transistor having a gate coupled to receive a second control signal different from the first control signal and having a source-drain path; a first static random access memory circuit which includes: first static memory cells, each first static memory cell having a first voltage supply point which is coupled to the first line via the source-drain path of the first P channel MOS transistor, and each first static memory cell being coupled to the second line; first word lines coupled to the first static memory cells; first word drivers coupled to the first word lines, each first word driver having a second voltage supply point which is coupled to the first line via the source-drain path of the second P channel MOS transistor, and each first word driver being coupled to the second line; and first bit lines coupled to the first static memory cells; and a second static random access memory circuit which includes: second static memory cells, each second static memory cell being directly coupled to the first line and coupled to the second line; second word lines coupled to the second static memory cells; second word drivers coupled to the second word lines, each second word driver being coupled to the first line and coupled to the second line; and second bit lines coupled to the second static memory cells.", "17.A semiconductor device according to claim 16, wherein each first static memory cell incudes: a flip-flop having a first storage node, a second storage node, a first CMOS inverter having an output coupled to the first storage node and an input coupled to the second storage node, and a second CMOS inverter having an output coupled to the second storage node and an input coupled to the first storage node, the first CMOS inverter including a first P channel load MOS transistor and a first N channel drive MOS transistor, the second CMOS inverter including a second P channel load MOS transistor and a second N channel drive MOS transistor; and first and second N channel transfer MOS transistors, each having a source-drain path coupled between a corresponding one of the first and second storage nodes and a corresponding one of the first bit lines and having a gate electrode coupled to a corresponding first word line, wherein the first and second P channel load MOS transistors have sources coupled to the first voltage supply point.", "18.A semiconductor device according to claim 17, wherein the first P channel MOS transistor and the second P channel MOS transistor are arranged at one side of the first static random access memory circuit.", "19.A semiconductor device according to claim 17, further comprising: a third P channel MOS transistor having a gate coupled to receive a third control signal different from the first and second control signals and having a source-drain path, and wherein the first static random access memory circuit includes a read/write amplifier coupled to the first bit lines and having a third voltage supply point which is coupled to the first line via the source-drain path of the third P channel MOS transistor.", "20.A semiconductor device according to claim 17, further comprising: a third P channel MOS transistor having a gate coupled to receive a third control signal different from the first and second control signals and having a source-drain path, wherein the first static random access memory circuit includes a pre-charge circuit, and wherein the pre-charge circuit includes: fourth and fifth P channel MOS transistors having drains coupled to the first bit lines, respectively, and sources which are coupled to a third voltage supply point which is coupled to the first line via the source-drain path of the third P channel MOS transistor, and a sixth P channel MOS transistors having a source-drain path coupled between the drains of the fourth and fifth P channel MOS transistors.", "21.A semiconductor device according to claim 17, wherein the first static random access memory circuit includes a row decoder coupled to the first word drivers, and wherein the row decoder has a third voltage supply point different from the first and second voltage supply points.", "22.A semiconductor device according to claim 17, wherein the first static random access memory circuit includes a row decoder coupled to the first word drivers, and wherein the row decoder is directly coupled to the first line and to the second line.", "23.A semiconductor device according to claim 17, further comprising: a first N channel MOS transistor having a gate coupled to receive a third control signal different from the first and second control signals and having a source-drain path, and a second N channel MOS transistor having a gate coupled to receive a fourth control signal different from the first, second and third control signals and having a source-drain path, wherein each first static memory cell has a third voltage supply point which is coupled to the second line via the source-drain path of the first N channel MOS transistor, and wherein each first word driver has a fourth voltage supply point which is coupled to the second line via the source-drain path of the second N channel MOS transistor.", "24.A semiconductor device according to claim 18, further comprising: a third P channel MOS transistor having a gate coupled to receive a third control signal different from the first and second control signals and having a source-drain path, and wherein each second word driver has a third voltage supply point which is coupled to the first line via the source-drain path of the third P channel MOS transistor.", "25.A semiconductor device according to claim 24, wherein the second word drivers are directly coupled to the second line.", "26.A semiconductor device according to claim 19, further comprising: a first N channel MOS transistor having a gate coupled to receive a fourth control signal different from the first, second and third control signals and having a source-drain path, and wherein the read/write amplifier has a fourth voltage supply point which is coupled to the second line via the source-drain path of the first N channel MOS transistor.", "27.A semiconductor device according to claim 17, wherein the first static random access memory circuit includes a read/write amplifier coupled to the first bit lines (BL,/BL) and a column decoder coupled to the read/write amplifier, and wherein the column decoder is coupled to the second voltage supply point.", "28.A semiconductor device according to claim 27, further comprising: a first N channel MOS transistor having a gate coupled to receive a third control signal different from the first and second control signals and having a source-drain path, wherein the column decoder and each first word driver have a third voltage supply point which is coupled to the second line via the source-drain path of the first N channel MOS transistor.", "29.A semiconductor device according to claim 18, further comprising: a third P channel MOS transistor having a gate coupled to receive a third control signal different from the first and second control signals and having a source-drain path, and a logic circuit including a CMOS inverter having an N channel MIS transistor and a P channel MIS transistor, the CMOS inverter having a third voltage supply point which is coupled to the first line via the source-drain path of the third P channel MOS transistor.", "30.A semiconductor device according to claim 29, further comprising: a bus coupled to the logic circuit and the first and second static random access memories.", "31.A semiconductor device according to claim 29, wherein the second static memory cells are directly coupled to the second line.", "32.A semiconductor device according to claim 29, wherein a thickness of a gate insulating film of the second P channel MOS transistor is greater than that of a gate insulating film of the P channel MIS transistor in the logic circuit.", "33.A semiconductor device according to claim 29, wherein a thickness of a gate insulating film of the second P channel MOS transistor is the same as that of a gate insulating film of the P channel MIS transistor in the logic circuit.", "34.A semiconductor device according to claim 17, wherein a thickness of a gate insulating film of the second P channel MOS transistor is greater than a respective thickness of a gate insulating film of the first P channel load MOS transistor in each first static memory cell.", "35.A semiconductor device according to claim 17, wherein a thickness of a gate insulating film of the second P channel MOS transistor is the same as a respective thickness of a gate insulating film of the first P channel load MOS transistor in each first static memory cell.", "36.A semiconductor device according to claim 19, further comprising: a fourth P channel MOS transistor having a gate coupled to receive a fourth control signal different from the first, second and third control signals and having a source-drain path, and a logic circuit including a CMOS inverter having an N channel MIS transistor and a P channel MIS transistor, the CMOS inverter having a fourth voltage supply point which is coupled to the first line via the source-drain path of the fourth P channel MOS transistor.", "37.A semiconductor device according to claim 36, further comprising: a bus coupled to the logic circuit and the first and second static random access memories.", "38.A semiconductor device according to claim 36, wherein the second static memory cells are directly coupled to the second line.", "39.A semiconductor device according to claim 36, wherein a thickness of a gate insulating film of the second P channel MOS transistor is greater than that of a gate insulating film of the P channel MIS transistor in the logic circuit.", "40.A semiconductor device according to claim 36, wherein a thickness of a gate insulating film of the second P channel MOS transistor is the same as that of a gate insulating film of the P channel MIS transistor in the logic circuit.", "41.A semiconductor device according to claim 20, further comprising: a fourth P channel MOS transistor having a gate coupled to receive a fourth control signal different from the first, second and third control signals and having a source-drain path, and a logic circuit including a CMOS inverter having an N channel MIS transistor and a P channel MIS transistor, the CMOS inverter having a fourth voltage supply point which is coupled to the first line via the source-drain path of the fourth P channel MOS transistor.", "42.A semiconductor device according to claim 41, further comprising: a bus coupled to the logic circuit and the first and second static random access memories.", "43.A semiconductor device according to claim 41, wherein the second static memory cells are directly coupled to the second line.", "44.A semiconductor device according to claim 41, wherein a thickness of a gate insulating film of the second P channel MOS transistor is greater than that of a gate insulating film of the P channel MIS transistor in the logic circuit.", "45.A semiconductor device according to claim 41, wherein a thickness of a gate insulating film of the second P channel MOS transistor is the same as that of a gate insulating film of the P channel MIS transistor in the logic circuit.", "46.A semiconductor device according to claim 21, further comprising: a third P channel MOS transistor having a gate coupled to receive a third control signal different from the first and second control signals and having a source-drain path, and a logic circuit including a CMOS inverter having an N channel MIS transistor and a P channel MIS transistor, the CMOS inverter having a fourth voltage supply point which is coupled to the first line via the source-drain path of the third P channel MOS transistor.", "47.A semiconductor device according to claim 46, further comprising: a bus coupled to the logic circuit and the first and second static random access memories.", "48.A semiconductor device according to claim 46, wherein the second static memory cells are directly coupled to the second line.", "49.A semiconductor device according to claim 46, wherein a thickness of a gate insulating film of the second P channel MOS transistor is greater than that of a gate insulating film of the P channel MIS transistor in the logic circuit.", "50.A semiconductor device according to claim 46, wherein a thickness of a gate insulating film of the second P channel MOS transistor is the same as that of a gate insulating film of the P channel MIS transistor in the logic circuit.", "51.A semiconductor device according to claim 22, further comprising: a third P channel MOS transistor having a gate coupled to receive a third control signal different from the first and second control signals and having a source-drain path, and a logic circuit including a CMOS inverter having an N channel MIS transistor and a P channel MIS transistor, the CMOS inverter having a third voltage supply point which is coupled to the first line via the source-drain path of the third P channel MOS transistor.", "52.A semiconductor device according to claim 51, further comprising: a bus coupled to the logic circuit and the first and second static random access memories.", "53.A semiconductor device according to claim 51, wherein the second static memory cells are directly coupled to the second line.", "54.A semiconductor device according to claim 51, wherein a thickness of a gate insulating film of the second P channel MOS transistor is greater than that of a gate insulating film of the P channel MIS transistor in the logic circuit.", "55.A semiconductor device according to claim 51, wherein a thickness of a gate insulating film of the second P channel MOS transistor is the same as that of a gate insulating film of the P channel MIS transistor in the logic circuit.", "56.A semiconductor device according to claim 23, further comprising: a third P channel MOS transistor having a gate coupled to receive a third control signal different from the first and second control signals and having a source-drain path, and a logic circuit including a CMOS inverter having an N channel MIS transistor and a P channel MIS transistor, the CMOS inverter having a fifth voltage supply point which is coupled to the first line via the source-drain path of the third P channel MOS transistor.", "57.A semiconductor device according to claim 56, further comprising: a bus coupled to the logic circuit and the first and second static random access memories.", "58.A semiconductor device according to claim 56, wherein the second static memory cells are directly coupled to the second line.", "59.A semiconductor device according to claim 56, wherein a thickness of a gate insulating film of the second P channel MOS transistor is greater than that of a gate insulating film of the P channel MIS transistor in the logic circuit.", "60.A semiconductor device according to claim 56, wherein a thickness of a gate insulating film of the second P channel MOS transistor is the same as that of a gate insulating film of the P channel MIS transistor in the logic circuit.", "61.A semiconductor device according to claim 27, further comprising: a third P channel MOS transistor having a gate coupled to receive a third control signal different from the first and second control signals and having a source-drain path, and a logic circuit including a CMOS inverter having an N channel MIS transistor and a P channel MIS transistor, the CMOS inverter having a third voltage supply point which is coupled to the first line via the source-drain path of the third P channel MOS transistor.", "62.A semiconductor device according to claim 61, further comprising: a bus coupled to the logic circuit and the first and second static random access memories.", "63.A semiconductor device according to claim 61, wherein the second static memory cells are directly coupled to the second line.", "64.A semiconductor device according to claim 61, wherein a thickness of a gate insulating film of the second P channel MOS transistor is greater than that of a gate insulating film of the P channel MIS transistor in the logic circuit.", "65.A semiconductor device according to claim 61, wherein a thickness of a gate insulating film of the second P channel MOS transistor is the same as that of a gate insulating film of the P channel MIS transistor in the logic circuit." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The summary of the representative inventions disclosed in this application will be described as follows.", "(1) In a LSI consolidating a logic circuit and an SRAM circuit, the power source of the logic circuit is cut off by the switch at the time of standby, and the SRAM circuit controls the substrate voltage of the MOS transistor so as to reduce the leakage current.", "(2) The power source of the control circuit for accessing the memory cell in the SRAM circuit is divided to be cut off, reducing the power consumption.", "(3) The SRAM circuit is divided so that some SRAMs hold data at the time of standby and other SRAMs not holding data cut off the power source to reduce the leakage current." ], [ "BACKGROUND OF THE INVENTION 1.Field of the Invention The present invention relates to a semiconductor device consolidating a logic circuit and a static memory (SRAM) circuit.", "2.Description of the Related Art Japanese Published Unexamined Patent Application No.", "Hei 7-86916 discloses a construction in which a logic circuit is provided with a power switch and a MOS transistor constructing the logic circuit is back-gate biased.", "Japanese Published Unexamined Patent Application No.", "2000-207884 discloses a substrate bias control technology for a system LSI operable at a low voltage including a static memory.", "Japanese Published Unexamined Patent Application No.", "2001-93275 discloses a construction in which a logic circuit is provided with a logic power source and a memory circuit is provided with a memory power source.", "Currently, semiconductor integrated circuits called a system LSI (Large Scale Integrated Circuit) integrating an SRAM circuit and a logic circuit on the same semiconductor chip are widely manufactured.", "The SRAM circuit refers to a circuit functioning as a memory by only the circuit including arrayed SRAM memory cells and a peripheral circuit for accessing the memory cells.", "The logic circuit refers to a circuit subjecting an inputted signal to a specified process for output, other than the memory circuit including arrayed memory cells such as an SRAM, a dynamic memory (DRAM) and a non-volatile memory and a circuit for accessing the memory cells.", "A circuit holding data such as a flip-flop in the logic circuit is thought to be part of the logic circuit.", "A request for low power consumption of the system LSI and finer transistors in the LSI lower the source voltage of the LSI.", "In a 0.13 μm process, a LSI operated at a source voltage of 1.2V is manufactured.", "When the source voltage is lowered, the electric current of the MOS transistor is reduced to deteriorate the circuit performance.", "To prevent the performance from being deteriorated, a LSI lowering the threshold voltage of the MOS transistor is manufactured.", "When the threshold value of the MOS transistor is lowered, a leakage current called a sub-threshold current of the MOS transistor is increased.", "The leakage current continues to flow at the time of operation or non-operation of the circuit.", "In the standby state, the SRAM does not perform write and read operations, but continues to hold data.", "The power consumption in the standby state of the system LSI is the leakage current of the MOS transistor in the circuit.", "When the threshold voltage of the MOS transistor is lowered, the power consumption in the standby state is increased.", "In the system LSI, the state that the logic circuit is not operated and the SRAM circuit holds data is called a standby state.", "The logic circuit is not operated at the time of standby.", "The logic circuit cuts off the power source using a switch to reduce the leakage current.", "The SRAM memory cell is of a flip-flop construction.", "The leak current is relatively small.", "In the prior art system LSI, the capacitance of the SRAM circuit mounted is not large and the SRAM memory cell is made by the MOS transistor having a high threshold value.", "The leakage current in the SRAM circuit has not been a problem.", "However, when the MOS transistor is made finer and a large-capacitance SRAM is mounted on the system LSI so as to lower the threshold voltage of the MOS transistor constructing the SRAM memory cell, the leakage current in the SRAM memory cell cannot be ignored.", "The logic circuit can reduce the leakage current at the time of standby when the power source is cut off by the switch.", "The SRAM circuit must hold data in the standby state.", "The power source cannot be cut off so that the leakage current cannot be reduced.", "When the voltage is lowered to reduce the threshold voltage of the MOS transistor, the leakage current in the circuit attached for accessing the memory cell in the SRAM circuit is increased.", "SUMMARY OF THE INVENTION The summary of the representative inventions disclosed in this application will be described as follows.", "(1) In a LSI consolidating a logic circuit and an SRAM circuit, the power source of the logic circuit is cut off by the switch at the time of standby, and the SRAM circuit controls the substrate voltage of the MOS transistor so as to reduce the leakage current.", "(2) The power source of the control circuit for accessing the memory cell in the SRAM circuit is divided to be cut off, reducing the power consumption.", "(3) The SRAM circuit is divided so that some SRAMs hold data at the time of standby and other SRAMs not holding data cut off the power source to reduce the leakage current.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a diagram showing an overview of the relation between a logic circuit and an SRAM circuit of a system LSI to which the present invention is applied and power sources thereof; FIG.", "2 is a schematic diagram of the layout of the system LSI of FIG.", "1; FIG.", "3 is a diagram showing change in voltage of nodes in the circuit shown in FIG.", "1; FIG.", "4 is a diagram showing an example of a control circuit CNTS in FIG.", "1; FIG.", "5 is a waveform chart of signals for changing the state of the circuit of FIG.", "1; FIG.", "6 is a diagram showing an example of a circuit generating signals shown in FIG.", "5; FIG.", "7 is a diagram showing the relation between the internal construction of the SRAM circuit to which the present invention is applied and power sources thereof; FIG.", "8 is a diagram showing the construction of the logic circuit to which the present invention is applied; FIG.", "9 is a diagram showing the constructions of transistors of the system LSI to which the present invention is applied; FIG.", "10 is a diagram showing a first modification of the switches of the logic circuit; FIG.", "11 is a diagram showing change in voltage of nodes in the circuit shown in FIG.", "10; FIG.", "12 is a diagram showing a second modification of the switches of the logic circuit; FIG.", "13 is a diagram showing a third modification of the switches of the logic circuit; FIG.", "14 is a diagram of an application of FIG.", "13; FIG.", "15 is a diagram in which a voltage dropping circuit is applied to the SRAM circuit; FIG.", "16 is a diagram showing change in voltage of nodes in the circuit shown in FIG.", "15; FIG.", "17 is a circuit diagram of a switch circuit CNTV1 in FIG.", "16; FIG.", "18 is a first modification of the SRAM circuit of FIG.", "7; FIG.", "19 is a second modification of the SRAM circuit of FIG.", "7; FIG.", "20 is a diagram in which substrate bias control is applied to the logic circuit; FIG.", "21 is a diagram showing a first modification dividing the SRAM circuit part; FIG.", "22 is a diagram showing the constructions of transistors constructing a plurality of SRAM circuits in FIG.", "21; FIG.", "23 is a diagram showing an application of the system of the invention of FIG.", "21; FIG.", "24 is a diagram showing a second modification dividing the SRAM circuit; FIG.", "25 is a diagram showing a third modification dividing the SRAM circuit; and FIG.", "26 is a diagram showing a circuit construction example of a power source control circuit CNVT2 in FIG.", "24.DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Embodiment 1 FIG.", "1 schematically shows the entire construction of a LSI consolidating a logic circuit and an SRAM circuit using the present invention.", "In FIG.", "1, a CHIP as the consolidated LSI includes an input/output circuit IO (IO circuit) having power voltage lines VssQ and VddQ from outside as operating voltages; a logic circuit LOGIC executing a predetermined process to data; a static memory circuit SRAM storing data; an nMOS transistor N1 as a switch between a ground voltage line Vss and an operating voltage supply line Vss1 on the low voltage side of the logic circuit; a control circuit CNTS to which a signal stby inputted in the standby state is inputted to be connected to the gate electrode of the N1 outputting a signal cntn controlling the N1; and a substrate bias control circuit VBBC controlling substrate voltages Vbn and Vbp of the SRAM when the stby is inputted.", "Unless otherwise specified, the power source with a symbol starting from Vdd is a power source supplying a high voltage, and the power source with a symbol starting from Vss is a power source supplying a low voltage.", "An operating voltage difference (VssQ-VddQ) supplied to the IO circuit is typically defined by the standard and is larger than an operating voltage difference (Vss-Vdd) of the logic circuit and the SRAM circuit.", "By way of example, 3.3V is supplied to the VddQ, 1.2V is supplied to the Vdd, and 0V is supplied to the Vss and the VssQ.", "The signal stby for use in the control circuit CNTS is used via the IO circuit.", "FIG.", "2 shows the layout of the circuit of FIG.", "1 on a semiconductor chip.", "A core circuit (the logic circuits and the SRAM circuit) is arranged so as to be surrounded by the input/output circuit IO (IO circuit).", "The IO circuit is connected to an input/output pad.", "AMOS transistor having a gate-insulating film thickness larger than that of the MOS transistor for use in the core circuit is used for the IO circuit.", "Since a source voltage higher than that of the core circuit is typically applied to the IO circuit, the voltage resistance is required.", "The power switch, the substrate bias control circuit VBBC, and the power switch control circuit CNTS included in a power source control system POW in FIG.", "1 are integrally arranged to increase the integration degree.", "It is advantageous when the transistor size (the channel length and the channel width) is different from that of the logic circuit and the SRAM circuit.", "The substrate bias control circuit has a control switch and a charge pump circuit.", "The nMOS transistor having a large insulating film thickness for use in the IO circuit is used for the N1 in FIG.", "1.The substrate voltage of the power switch N1 is connected to the source side.", "Unless otherwise specified, the substrate voltages of the N channel type and the P channel type MOS transistors constructing the switch connected to the power source are connected to the source voltages of the transistors.", "Use of the thick-film MOS transistor is effective for the tunnel leakage current prevention of the gate.", "Since the voltage resistance is excellent, the voltage applied to the gate of the switch N1 can be larger than the operating voltage and the leakage current when the nMOS is allowed to be nonconductive can be reduced.", "When there is only one film thickness of the transistor constructing the LSI and the MOS transistor for use in the IO circuit cannot be used in the core part for design, a MOS transistor having a small insulating film thickness can be used as a switch.", "In this case, the leakage current cannot be cut off completely by the switch N1.When the leak current is within an allowable range, the MOS switch may be only made by the thin-film MOS transistor.", "When the leakage current exceeds the allowable value, the substrate voltage of the logic circuit and the switch N1 or only the switch N1 must be controlled to reduce the leakage current.", "The nMOS transistor is used as a switch cutting off the power source.", "The nMOS has a flowing current larger than that of the pMOS.", "When attempting to flow the same current, the switch size can be reduced.", "When the switch size is not considered due to enough area, the switch of the pMOS cutting off the power source Vdd can be inserted without inserting the switch of the nMOS cutting off the ground power source Vss.", "FIG.", "3 shows an example of the voltages of an active state ACT and a standby state STB of the parts of the circuit.", "The active state ACT represents a state that the logic circuit and the SRAM circuit are operated.", "The Vdd and the Vss in FIG.", "1 are power sources of the core including the SRAM circuit and the logic circuit.", "The Vdd voltage is 1.2V and the Vss voltage is 0.0V.", "The standby signal stby is low in the active state.", "The control signal of the switch is high and the nMOS switch is on.", "The Vbn and the Vbp as the substrate voltages of the nMOS transistor and the pMOS transistor of the SRAM circuit are 0V and 1.2V.", "The substrate bias Vbs applied to the MOS transistor in the SRAM circuit is 0V.", "The threshold voltage of the MOS transistor constructing the SRAM circuit is not changed as compared with values determined by the transistor construction (gate width, gate length and implantation amount).", "In the standby state, the standby signal stby is high.", "With it, the signal cntn controlling the nMOS switch is low and the nMOS switch is nonconductive.", "At the same time, the Vbn and the Vbp as the substrate voltages of the nMOS transistor and the pMOS transistor constructing the SRAM circuit are—1.2V and 2.4V.", "A substrate bias of 1.2V is applied to the MOS transistor in the SRAM circuit to increase the threshold voltage of the MOS transistor.", "The leakage current of the MOS transistor is reduced.", "A circuit generating the signal cntn controlling the switch using the inputted standby signal stby can be realized by the simplified circuit as shown in FIG.", "4.When using the circuit of FIG.", "4, the high standby signal stby must be always inputted in the standby state STB, as shown in FIG.", "3.For example, there is considered the case that the standby signal stby is inputted only in the standby state STB and an active signal ack is inputted when the standby state STB is changed to the active state.", "ACT.", "FIG.", "5 shows the voltage change of the standby signal stby, the active signal ack and the control signal cntn in this case.", "When the standby signal stby is inputted, the control signal cntn is low to turn off the power switch, reducing the leakage current.", "When the active signal ack is inputted, the control signal cntn is high to make the power switch conductive, supplying power to the logic circuit.", "FIG.", "6 shows the circuit CNTS for outputting the signals of the waveform of FIG.", "5.To store the standby state STB in the circuit, a flip-flop is used.", "In this case, a signal for returning to the active state ACT is prepared.", "FIG.", "7 shows a construction example of the SRAM circuit SRAM in FIG.", "1.The SRAM circuit includes a memory cell array MAR, peripheral circuits PERI1 and PERI2 for accessing the memory cells, and an inverter to input an inverted signal of the signal stby transmitting the standby state to the gates of MOS transistor s_sw2 and s_sw1 and s_sw2m as switches for cutting off the power lines Vss and Vdd of the PERI1 or the PERI2.The substrate voltage of the P channel type MOS transistor included in SRAM_CIR is connected to the Vbp and the substrate voltage of the N channel type MOS transistor included therein is connected to the Vbn so as to control the substrate-bias voltage.", "The MAR is a circuit having the arrayed SRAM memory cells.", "The memory cell has a pair of flip-flops (a first and second P channel type load MOS transistors and a first and second N channel type drive MOS transistors) having the input and the output of a CMOS inverter interconnected, and a first and second N channel type transfer MOS transistors connected between two storage nodes and bitlines (BL,/BL) of the flip-flops.", "The gate electrode of the N channel type transfer MOS transistor is connected to a wordline WL.", "The operating voltage of the memory cell is given by Vddma and Vssma.", "The peripheral circuit PERI1 includes a circuit for controlling the wordline WL of the memory cell including a word driver WDR, a row decoder RDEC, and a memory controller MCNT.", "The operating voltage of the circuit included in the PERI1 is given by Vddper and Vssper.", "The peripheral circuit PERI2 includes a circuit for controlling a bitline BL of the memory cell including a pre-charge circuit PRE, a read/write amplifier RWAMP as a read/write control circuit connected to the bitline and a column decoder CDEC.", "The read/write amplifier RWAMP includes OBUF as an output buffer of a sense amplifier and WCNT as a control circuit of the write amplifier.", "The operating voltage of the circuit included in the PERI2 is given by Vddamp and Vssamp.", "A low signal is inputted to/stby in the drawing at the time of the standby STB.", "At the time of standby, the power line Vdd inputted to the PERI1 is cut off, and at the same time, the power line Vss inputted to the PERI2 is cut off.", "The Vbn and the Vbp supplying the substrate voltage of the MOS transistor constructing the MAR, PERI1 and PERI2 are controlled so as to increase an absolute value of the threshold voltage of the MOS transistor.", "The substrate bias is applied to the SRAM memory cell.", "The substrate bias is applied to the peripheral circuit.", "The power source is provided with the switch to reduce the leakage current.", "The power consumption of the SRAM at the time of standby can be reduced.", "There will be described next a reason why the peripheral circuit is divided into two to cut off the Vss and the Vdd in FIG.", "7.The wordline is low in the standby state and is low also in the operating state except for the selected wordline.", "The circuit driving the wordline cuts off the power source Vdd as the high voltage to reduce the leakage current when compared to cutting off the power source Vss as the low voltage.", "Time for returning from the standby state is shortened.", "The switch inserted in the Vdd side is smaller than that inserted in the Vss side.", "The bitline is typically charged to the Vdd in the SRAM.", "In many cases, the amplifier is of a construction in which the state charged to the Vdd is stable.", "The bitline is charged to the Vdd at the time of standby to cut off the power source Vss of the read amplifier and the write amplifier by the switch.", "The leakage current can be thus reduced.", "Time for returning from the standby state to the active state is shortened.", "In the circuit pre-charging the bitline to the Vdd, the Vss of the circuit driving the bitline is cut off, which is advantageous in the leakage current and the return time.", "In the circuit pre-charging the bitline to the Vss, cutting off the switch on the Vdd side is naturally advantageous, providing the construction.", "The circuit in FIG.", "7 is assumed to be the SRAM in the system LSI as shown in FIG.", "1, and can be applied to a memory LSI without being limited to the system LSI.", "FIG.", "7 is a diagram controlling the substrate bias of the SRAM circuit.", "When the leakage of the peripheral circuit can be reduced to sufficiently reduce the power consumption in the standby state, the substrate bias is not necessarily applied.", "In the case that the characteristic of the MOS transistor will be varied in the future to make the leakage current called a junction leakage of the MOS transistor larger than the leakage current called a sub-threshold of the MOS transistor, the method for controlling the substrate voltage may not reduce the leakage current.", "In this case, a construction in which the power sources of the logic circuit and the peripheral circuits of the SRAM in the system LSI are cut off by the switches can be thought to be an important technology.", "FIG.", "8 shows a construction example of the logic circuit LOGIC in FIG.", "1.In a logic circuit LOGIC_CIR, the logic gates such as NAND and NOR as the inverter having the P channel type MOS transistor and the N channel type MOS transistor are combined for multiple-stage connection.", "The substrate voltage is not applied to the transistor in the logic circuit.", "The substrate voltage of the P channel type MOS transistor is connected to the high voltage side Vdd of the operating voltage and the substrate voltage of the N channel type MOS transistor is connected to the low voltage side Vssl of the operating voltage.", "FIG.", "9 shows the constructions of the types of a MOS transistor for use in the logic circuit and the SRAM circuit (CORE) in the LSI, a MOS transistor for use in the input/output circuit IO of the LSI, a MOS transistor for use in the switch logic sw cutting off the power source of the logic circuit shown in FIG.", "1, and a MOS transistor for use in the switch s sw cutting off the power sources of the peripheral circuits of the SRAM shown in FIG.", "7.The threshold voltages of the P channel type.", "MOS and the N channel type MOS transistors are different.", "The polarity is typically inverted to be designed to be the same value.", "FIG.", "16 shows its absolute value.", "A transistor having a large insulating film thickness is used for the input/output circuit part of the LSI.", "A transistor having a small insulating film thickness is used for the internal logic circuit.", "In this drawing, there are used a MOS transistor having a large insulating film thickness of 6.7 nm and a MOS transistor having a small insulating film thickness of 2.0 nm.", "As the transistor having a small film thickness, a MOS transistor having two or more threshold voltages depending on a difference in impurity amount is often used.", "In FIG.", "9, a MOS transistor having two threshold voltages Vth of 0.40V and 0.25V is taken as an example.", "The current at the time of operation of the MOS transistor having a low threshold voltage is large and the leakage current at the time of standby is increased.", "In all the combinations, the MOS transistor of a thin gate-insulating film having two types of Vth is used for the logic circuit LOGIC_CIR and the SRAM circuit SRAM_CIR except for the control switch, and the MOS transistor of a thick gate-insulating film having a high Vth is used for the IO.", "In the LOGIC_CIR, a transistor having a low threshold value is used for a critical path and a transistor having a high threshold value is used for the remaining circuits.", "In the SRAM_CIR, to reduce the leakage current and to maintain static noise margin (SNB), a transistor having a high threshold value is used for the memory cell array MAR.", "Since the peripheral circuit PERI including the pre-charge circuit, the sense amplifier, the word driver and the decoder must be fast, a MOS transistor having a low threshold value is used.", "In the combination of Patternl, the thick-film MOS transistor having a high Vth is used for the power switch of the logic circuit, and the thin-film MOS transistor having a high Vth is used for the power switch of the peripheral circuit in the SRAM circuit.", "The thick-film MOS transistor is used for the power switch of the logic circuit to reduce the leakage current of the large-scale circuit.", "The SRAM controls the substrate bias to reduce the leakage current.", "The thin-film MOS transistor having a slightly large leakage is used for the power switch to reduce the entire leakage current.", "When the circuit size of the peripheral circuit in the SRAM circuit is not large, the leakage current of the peripheral circuit is considered to be small.", "The construction of the Patternl is effective.", "When designing the SRAM circuit as a module which can be easily reused, the SRAM circuit can be designed in consideration of the characteristic of only the thin-film MOS transistor.", "The switch is made by the thin-film MOS transistor to enhance the design efficiency.", "The construction of the Patternl is effective when the size of the SRAM circuit itself is not large, the size of the peripheral circuit in the SRAM circuit is not large, reduction of the leakage current is highly expected by controlling the substrate bias, or the design efficiency of the SRAM is considered.", "In the combination of Pattern2, the thick-film MOS transistor having a high Vth is used for the power switch of the logic circuit and the power switch of the peripheral circuit in the SRAM circuit.", "This can reduce the leakage current of the circuit other than the SRAM memory cell in the LSI.", "The power consumption at the time of standby is smaller than that of the Patternl.", "When designing the SRAM circuit, the characteristic of the thick-film MOS transistor must be considered.", "The design efficiency is thus lowered.", "The combination of the Pattern2 is effective when the size of the SRAM circuit is large, the size of the peripheral circuit of the SRAM is large, or an effect for reducing the leakage current by controlling the substrate bias is not highly expected.", "In the combination of Pattern3, the thin-film MOS transistor having a high Vth is used for the power switch of the logic circuit and the power switch of the peripheral circuit in the SRAM circuit.", "In this case, the thin-film MOS transistor is used.", "An effect for reducing the leakage current is lower than that of the Pattern2.Since the characteristic of the thick-film MOS transistor need not be considered, the design efficiency is enhanced.", "The combination of the Pattern3 is effective when the effect for reducing the leakage current of the LSI is less large and the design efficiency is required.", "As described above, the power source of the logic circuit is cut off by the switch in the standby state and the substrate bias is applied to the SRAM circuit.", "The leakage current of the system LSI is lowered to reduce the power consumption in the standby state.", "Embodiment 2 This embodiment shows a modification of the power switch for use in the logic circuit.", "FIG.", "10 shows a circuit block diagram when the power switch mounted only on the power source Vss of the logic circuit part in the circuit of FIG.", "1 is provided in the power sources Vdd and Vss.", "The two power sources Vdd and Vss of the logic circuit are provided with the switch to cut off the power source.", "The area is increased by providing the power switch.", "The leakage current at the time of standby can be cut off more reliably.", "FIG.", "1 illustrates the IO circuit, but is omitted in FIG.", "10.The IO circuit in the CHIP is omitted in other drawings.", "FIG.", "11 shows the voltages of the parts of the circuit when using the circuit of FIG.", "10.In this drawing, a signal cntp controlling P1 of the pMOS as a switch for cutting off the Vdd of the logic part is added to the voltages of FIG.", "3.The cntp is low in the active state ACT and is high in the standby state STB.", "The internal circuit of a circuit CNTS2 outputting the control signal in FIG.", "7 is not particularly described.", "A circuit outputting a phase reversal signal can be added to the circuit of FIG.", "4 or FIG.", "6.In FIGS.", "1 and 10, the circuit when the logic circuit in FIG.", "1 is unified is described.", "FIG.", "12 shows a block diagram of a circuit when the present invention is applied to the LSI in which the logic circuit is divided into two or more blocks.", "FIG.", "12 shows an example when the logic circuit is divided into two blocks.", "When it is divided into three or more blocks, the same construction can be applied.", "The memory consolidated LSI shown in FIG.", "12 has logic circuits LOGIC1 and LOGIC2, ground voltage power lines Vss11 and Vss12 of the LOGIC1 and the LOGIC2, switches N2 and N3 connecting the Vss11 and the Vss12 to the power line Vss of the entire LSI, the static memory circuit SRAM, the control circuit CNTS of the switch, and the circuit VBBC controlling the substrate voltage of the SRAM.", "It is of the same construction as the circuit of FIG.", "1 except that there are a plurality of logic circuits and the operation is the same as that of the circuit of FIG.", "1.The logic circuit is divided into a plurality of blocks which are provided with a switch cutting off the power source.", "An optimum switch can be added to each of the blocks.", "For example, an nMOS switch cutting off the Vss is added to some logic blocks and a pMOS switch cutting off the Vdd is added to other blocks.", "Otherwise, a switch cutting off the two power sources Vdd and Vss can be provided depending on the block.", "In the memory consolidated LSI shown in FIG.", "13, the power switch is added to each of the blocks of the logic circuit so that the power switch is controlled by other signals cntn1 and cntn2.The LSI has a control circuit CNTS3 which can separately control the control signals cntnl and cntn2.These points are different from FIG.", "12.The CNTS3 is a circuit which can control the control signals cntn1 and cntn2 of the power switch and permits control so that the switch N2 is cut off and the switch N3 is conductive depending on the operating state of the circuit Thus, the block of the logic circuit which must be operated in the standby state is operated and the block of the logic circuit and the SRAM circuit which can be stopped are brought into the standby state, reducing the leakage current.", "In FIG.", "13, as in the case of FIG.", "12, when there are three or more logic blocks, it is possible to make a combination cutting off the power source on the Vss side, the power source on the Vdd side or both for each of the blocks.", "In the construction of FIG.", "13, the power supply for each of the blocks is controlled so as to bring the standby state, that is, the low leakage state.", "Not only in the standby state but also in the active state, the power switch is controlled so that the logic circuit and the SRAM circuit which need not be operated are brought into the standby state, minimizing the leakage current.", "FIG.", "14 shows an example in which the embodiment of FIG.", "13 is applied to a system (microcomputer) equipped with a central processing unit.", "The system LSI has a logic circuit block CPU called a central processing unit CPU permitting various arithmetic operations, a logic circuit block DSP dedicated for digital signal operation, a static memory block SRAM circuit, a bus BUS connecting the blocks exchanging data, a circuit BSCNT controlling the bus, and a circuit IO exchanging data with outside.", "The respective blocks exchange data via the bus in the active state.", "Whether the bus is operated or not is found by monitoring the operating state of the bus.", "For example, when the entire circuit is not operated, the circuit BSCNT controlling the bus transmits that all the blocks are in the standby state, to the control circuit CNTS3 of the switch by a signal stat1.The CNTS3 makes the cntn1 and the cntn2 low to cut off the switches N2 and N3, reducing the leakage current of the logic circuit.", "At the same time, the VBBC controls the Vbn and the Vbp as the substrate voltages of the SRAM to lower the leakage current of the SRAM, reducing the leakage current of the entire circuit.", "When only the CPU is operated and there is no access to the DSP and the SRAM via the bus, the BSCNT outputs the information via the statl to allow the substrate voltage of the SRAM to be in the standby state, to cut off the power switch N3 of the DSP to allow the DSP to be in the standby state, and allows only the CPU to be in the active state.", "Embodiment 3 FIG.", "15 schematically shows the entire construction of the LSI consolidating the logic circuit and the SRAM circuit using the present invention.", "The CHIP as the consolidated LSI includes the logic circuit LOGIC; the static memory circuit SRAM; the nMOS transistor N1 as a switch between the ground voltage line Vss from outside and the ground voltage line Vss1 of the logic circuit; the control circuit CNTS to which the signal stby inputted in the standby state is inputted to be connected to the gate electrode of the N1 outputting the signal cntn controlling the N1 ; the substrate bias control circuit VBBC controlling the substrate voltages Vbn and Vbp of the SRAM when the stby is inputted; and a circuit CNTV1 controlling the power line Vddm of the SRAM by the stby signal.", "The construction of FIG.", "15 is the same as that of the circuit of FIG.", "1 except for the CNTV1.Other than the CNTV1, it is operated as in FIG.", "1.The CNTV1 is brought into the standby state and the stby signal is inputted.", "The source voltage of the SRAM is lower than the Vdd which can hold data from the Vdd.", "This controls the substrate voltage of the SRAM in the standby state to reduce the leakage current.", "Since the source voltage is lowered, the leakage current can be further reduced.", "The power consumption at the time of standby can be lower than that of the circuit of FIG.", "1.FIG.", "16 shows the voltages at the time of active ACT and the time of standby STB of the parts of the circuit of FIG.", "15.The voltage of the power source Vdd of the circuit exhibits 1.2V.", "The stby, cntn, Vbn and Vbp are the same as those of FIG.", "3 as the operating voltages of FIG.", "1.The source voltage Vddm of the SRAM is 1.2V at the time of active ACT which is the same as the source voltage and is 0.6V at the time of standby STB.", "This can reduce the leakage current in the SRAM.", "The power source control circuit CNTV1 in FIG.", "15 can be realized by the circuit of FIG.", "16.The CNTV1 has a voltage dropping circuit PDC and a circuit changing switch.", "When the SRAM circuit is in the active state ACT, the circuit changing switch connects the power line Vddm supplying the operating voltage to the memory cell in the SRAM circuit to the power source Vdd supplied from outside so that the source voltage of the SRAM circuit is equal to the Vdd.", "In the standby state STB, the signal stby switches the circuit changing switch to connect Vddlow which is above the voltage lower than the Vdd produced by the voltage dropping circuit holding data in the memory cell of the SRAM and the power source Vddm of the SRAM circuit.", "The source voltage of the SRAM circuit is lower than the Vdd.", "In FIG.", "15, the voltage is dropped on the high voltage side.", "The power source control circuit CNTV1 is connected between Vssm and the Vss so that the CNTV1 can be a voltage raising circuit.", "The raised voltage or a combination of the raised and dropped voltages on the low voltage side can obtain the same effect.", "Embodiment 4 FIG.", "18 shows a modification of the circuit of FIG.", "7.In FIG.", "7, the power sources of the memory cell array are the Vddma and the Vssma, the power sources of the circuit RWAMP including the circuit driving the bitline are the Vddamp and the Vssamp, and the power sources of other circuits are the Vddper and the Vssper.", "The power source in the SRAM circuit is divided into three systems.", "A switch having the N channel type MOS transistor is inserted between the peripheral circuit PERI2 for use in control of the bitline and the power source on the low voltage side.", "A switch having the P channel type MOS transistor is inserted between the peripheral circuit PERI1 for use in control of the wordline and the power source on the high voltage side.", "The switches are inserted in the high voltage side and the low voltage side of the three-system power sources to cut off the power sources at the time of standby.", "In this circuit, the switches constructed by the MOS transistor are inserted in all the power sources.", "At the time of standby, control signals cntmp1 and cntmp2 become low, a control signal cntmp3 becomes high, control signals cntmnl and cntmn3 become high, and a control signal cntmn2 becomes low.", "Switches P6, P7, N6 and N8 are conductive to cut off switches P8 and N7, realizing the construction of FIG.", "7.To hold information of the SRAM memory cell, the P6 and the N6 must be conductive at the time of standby.", "When the SRAM circuit is divided into blocks, as described later, use of the construction cutting off the P6 and the N6 in the block which need not hold the information is effective in low power consumption.", "Without allowing the signal cntmn2 applied to the switch controlling the Vssamp at the time of standby to be low, the cntmp2 is allowed to be high.", "It is possible to realize a circuit cutting off the power source on the Vdd side of the read/write amplifier which is considered to be used in the circuit pre-charging the bitline to be low.", "In the circuit shown in FIG.", "18, some kinds of circuits can be realized depending on the control method of the control signal.", "FIG.", "19 shows a circuit which partly modifies of the circuit of FIG.", "7.The power source of the column decoder CDEC is connected to the Vddper and the Vssper.", "In FIG.", "7, the column decoder CDEC cuts off the power source on the Vss side.", "The column decoder is arranged near the amplifier.", "When the same switch as that of the amplifier cuts off the power source, the circuit design is considered to be facilitated.", "The power source is shared between the column decoder and the circuit controlling the wordline to cut off the power source of the Vdd side.", "Unless the design of the power source arrangement is complicated, the Vdd side can be cut off.", "The column decoder controls the bitline and has many nodes having the low voltage at the time of operation as in the word driver WDR (the number of the selection lines is larger than that of the non-selection lines).", "It is advantageous to provide the same operating voltages Vddper and Vssper as those of the memory controller MNCT using the switch on the high voltage side.", "By the same reason, although not shown, the control circuit WCNT of the write amplifier is desirably connected to the Vddper and the Vssper In FIG.", "19, there are prepared the switches for the three-power sources of FIG.", "18 (the switches of the P channel type MOS transistors provided between the Vdd and the Vddma, and the Vddamp and the Vddper; and the switches of the N channel type MOS transistors provided between the Vss and the Vssma, and the Vssamp and the Vssper) and the power line not via the switch.", "For the construction, depending on whether the switch for cutting off is provided on the low voltage side or the high voltage side, the SRAM circuit is blocked.", "The P channel type MOS transistor connected to the Vddamp and the N channel type MOS transistor connected to the Vssper can be omitted.", "In this circuit, unlike FIG.", "7, the power source connected to the row decoder RDEC is directly connected to the power sources Vdd and Vss outside the SRAM circuit, not to the cuttable power source in the SRAM circuit.", "Power is supplied to the row decoder at the time of standby This prevents the transfer MOS in the memory cell from being conductive due to noise on the wordline caused by a time difference in power supply at the time of returning from the standby state.", "The noise is produced because the power source of the previous-stage circuit of the power source of the word driver rises quickly to input a low signal to the word driver, and then, the word driver outputs a high signal.", "Power is supplied to the row decoder at the time of standby.", "The low signal is not inputted to the word driver.", "The noise cannot be provided on the wordline.", "In FIG.", "19, the power source of the entire row decoder is directly connected to the power sources Vdd and Vss supplied from outside.", "The circuit construction cannot reduce the leakage current of the row decoder.", "Although not shown, the power source of the entire row decoder is not connected to the Vdd and the Vss.", "The Vdd and the Vss are connected only to the previous-stage circuit of the word driver, e.g., the NAND circuit.", "There can be considered a circuit construction in which the power source cut off by the switch is connected to other circuits of the row decoder.", "The circuit construction can reduce the leakage current.", "The power source arrangement in the row decoder is complicated so that the design is difficult.", "When the size of the row decoder in the SRAM circuit is relatively large and the leakage current of the row decoder must be reduced, the power sources Vdd and Vss supplied from outside are connected only to the previous-stage circuit of the word driver.", "The power source which can cut off the power source at the time of standby by the power switch is connected to other circuits of the row decoders.", "When the size of the row decoder is not large and the influence of the leakage current of the row decoder is less, all the power sources of the row decoder are connected to the Vdd and the Vss.", "This construction is considered to be effective.", "As shown in FIG.", "19, the power source of the peripheral circuit of the SRAM is divided by function for control to reduce the leakage current of the peripheral circuit of the SRAM.", "Embodiment 5 FIG.", "20 shows a construction diagram in which the LSI consolidating the logic circuit and the SRAM circuit of FIG.", "1, substrate bias control is performed not only to the SRAM circuit but also to the logic circuit.", "The CHIP as the consolidated LSI includes the logic circuit LOGIC; the static memory circuit SRAM; the nMOS transistor N1 as a switch between the power source Vss and the ground voltage line Vssl of the logic circuit; a switch SW1 selecting, to which Vdd, Vss, Vbn and Vbp, the substrate voltage lines Vbn1, Vbp1, Vbnm and Vbpm of the MOS transistor constructing the logic circuit and the SRAM circuit are connected; a control circuit CNTS4 outputting the signal cntn controlling the N1 and signals cntvbb1 and cntvbb2 controlling the switch SW1; and a substrate bias control circuit VBBC2 producing the substrate bias Vbn and Vbp.", "The voltages of the parts at the time of active and standby are shown in FIG.", "3 At the time of standby, the power source of the logic circuit is cut off.", "The substrate voltage of the logic circuit is controlled to reduce the leakage current of the logic circuit.", "When the power switch of the logic circuit is made by the MOS transistor having a low threshold value, as shown in the Pattern3 of FIG.", "9 and there is a leakage current in the power switch, the substrate bias is applied to reduce the leakage current of the logic circuit.", "The circuit is thus effective.", "In the circuit, the substrate voltages of the logic circuit and the SRAM circuit can be controlled independently.", "Only the SRAM circuit is allowed to be in the standby state and the logic circuit is allowed to be in the active state.", "When only the logic circuit is operated, the leakage current in the SRAM circuit can be reduced.", "The substrate bias is applied to the logic circuit to operate the SRAM circuit, reducing the leakage current of the logic circuit.", "The switch which can select whether the substrate bias is applied to the logic circuit and the SRAM circuit is provided, permitting an operation to reduce the leakage current corresponding to the operating state.", "The block controlling the substrate voltage is controlled finely.", "The substrate bias is applied to change the load amount varying the voltage.", "That is, when the switch is provided so as not to apply the substrate bias to the unnecessary parts, the load which must change the voltage is reduced.", "Time to change the voltage can be shortened.", "Embodiment 6 FIG.", "21 shows a first modification in which the SRAM circuit of FIG.", "1 is divided into blocks.", "In FIG.", "24, the CHIP as the consolidated LSI includes the logic circuit LOGIC; static memory circuits SRAM1 and SRAM2; an nMOS transistor N9 as a switch between the power source Vss and the ground voltage line Vssl of the logic circuit; an nMOS transistor N10 as a switch between the power source Vss and a ground voltage line Vssm1 of the SRAM1; the control circuit CNTS outputting the signal cntn controlling the N9 and the N10; and the substrate bias control circuit VBBC producing the substrate bias Vbn and Vbp.", "The SRAM circuits SRAM1 and SRAM2 can be of the same construction as that of FIG.", "7 and the already described modification of FIG.", "7.In the circuit, the SRAM circuit of FIG.", "1 is divided into two blocks of the SRAM1 and the SRAM2.At the time of standby, the power sources of the logic circuit and the SRAM1 are cut off and the substrate bias is applied to the SRAM2 to reduce the entire leakage current, reducing the power consumption at the time of standby As compared with the circuit of FIG.", "1, the leakage current of the circuit of the SRAM1 can be reduced.", "In the construction, however, data stored into the SRAM1 is erased at the time of standby.", "Data which must be stored at the time of standby must be stored into the SRAM2.In the system LSI, some SRAM blocks are consolidated so that blocks which must and need not hold data at the time of standby are often consolidated.", "In such circuit, the circuit construction is used to provide a large effect for reducing the leakage current.", "FIG.", "22 shows a combination of the MOS transistors for use in the memory cell circuits of the divided two SRAM circuits.", "In the drawing, as in FIG.", "9, the MOS transistor having a large insulating film thickness of 6.7nm and the MOS transistor having a small insulating film thickness of 2.0nm are used.", "As an example in which the MOS transistor with a small film thickness has two threshold voltages, the MOS transistor having two threshold voltages Vth of 0.40V and 0.25V is used.", "A MAR1 represents the MOS transistor of the memory cell of the SRAM1 cutting off the power source.", "A MAR2 represents the MOS transistor of the memory cell of the SRAM2 not cutting off the power source.", "As described in the table of FIG.", "9, the MOS transistor having two threshold values is used for the logic circuit LOGIC_CIR.", "The MOS transistor having a low threshold value is used for about 10% in the logic circuit.", "They are allocated to the transistors in a critical path.", "The MOS transistor of the peripheral circuit except for the memory cell of the SRAM is not shown.", "The MOS transistor having the same threshold value as the low threshold value of 0.25V of the logic circuit is used.", "The thin-film MOS transistor is used in any case.", "The IO represents the MOS transistor for use in the input/output circuit.", "The thick-film MOS transistor having a high threshold voltage is used in any of the coMbinations.", "In a Pattern1, the thin-film MOS transistor having a high threshold voltage is used for the memory cell in all the SRAM circuit blocks.", "The construction is thought to reduce the area of the memory cell and has the excellent operating stability of the SRAM.", "In a combination of the Pattern2, the SRAM memory cell to which the power switch is not added is made by the thick-film MOS transistor having a small leakage current to reduce the leakage current.", "In the combination, the transistor constructing the memory cell in the SRAM1 including the power switch is made by the thin-film MOS transistor.", "The area is small and the operation is fast.", "The leakage current can be reduced by the power switch.", "The transistor constructing the memory cell in the SRAM2 not including the power switch is made by the thick-film MOS transistor.", "The leakage current at the time of standby can be reduced.", "The area of the memory cell of the SRAM2 is considered to be increased.", "The transistor is used in the circuit in which the circuit area is not cared much and the leakage current must be reduced reliably.", "The highest advantage of the circuit is thus obtained.", "When the circuit size of the SRAM2 is small, the combination is effective.", "In a Pattern3, the memory cell of the SRAM1 is made by the thin-film MOS transistor having a low threshold voltage.", "The memory cell of the SRAM2 is made by the thin-film MOS transistor having a high threshold voltage.", "When the threshold value of the MOS transistor constructing the memory cell of the SRAM is lowered, there are problems that the leakage current is made higher to increase the power consumption at the time of standby and the operating margin of the SRAM itself is lost so as not to operate the memory cell itself.", "The former problem can be avoided by providing the power switch.", "The combination can be realized only when using the MOS transistor having a characteristic so as not to exhibit the latter problem significantly.", "In a Pattern4, the thick-film MOS transistor is used as the MOS transistor constructing the SRAM2 memory cell of the combination of the Pattern3.This increases the circuit area than that of the Pattern3.The leakage current can be reduced.", "FIG.", "23 shows an application of FIG.", "21.The CHIP as the consolidated LSI includes the logic circuit LOGIC; the static memory circuits SRAM1 and SRAM2; the BUS as a bus transferring data between the logic circuit and the SRAM circuit; an nMOS transistor N9 as a switch between the power source Vss and the ground voltage line Vss1 of the logic circuit; the nMOS transistor N10 as a switch between the power source Vss and the ground voltage line Vssm1 of the SRAM1; a control circuit CNTS5 outputting the control signals cntn and dtran in the standby state; and the substrate bias control circuit VBBC producing the substrate bias Vbn and Vbp.", "Typically, in the system LSI, data is exchanged between the logic circuit and the SRAM circuit via the bus.", "The bus is considered to exist in the circuit of the system LSI of FIG.", "21.The circuit of FIG.", "23 is different from the circuit of FIG.", "21 in that it has the CNTS5 as the control circuit in the standby state.", "The operation of the circuit and the operation of the bus will be described.", "When the LSI is allowed to be in the standby state, the control circuit CNTS5 controls the logic circuit using the control signal dtran to escape data in the SRAM1 which must be stored at the time of standby to the SRAM2 via the bus.", "Upon completion of the escape, the escape completion is transmitted to the control circuit CNTS5 via the dtran.", "The control circuit CNTS5 outputs a signal for change to the standby state to cut off the power sources of the logic circuit and the SRAM1 by the switch.", "Then, the substrate bias to reduce the leakage current is applied to the SRAM2.For returning from the standby state to the active state, the control circuit CNTS5 outputs a signal to supply power to the logic circuit and the SRAM1, and then, the substrate bias in the standby state of the SRAM2 is switched to the bias in the active state.", "When the source voltages of the logic circuit and the SRAM1 and the substrate voltage of the SRAM2 are stable, the circuit controlling the bus via the control signal dtran is controlled to restore data of the SRAM1 escaped to the SRAM2.The circuit can hold data which must be held at the time of standby and reduce the leakage current of the memory cell of data which need not be held.", "FIG.", "24 shows the SRAM circuit of a second modification in which the SRAM circuit is divided into blocks and its power source control circuit part.", "In FIG.", "15, the CNTV1 controls the voltage on the high voltage side of the SRAM circuit by one voltage dropping circuit.", "Optimum control (The voltage of the SRAM1 is dropped and the voltage of the SRAM2 is not dropped since read and write operations are performed) can be performed for each of the blocks by dividing the SRAM circuit.", "As in the case of FIG.", "15, the voltage is not dropped on the high voltage side and the raised voltage or a combination of the raised and dropped voltages on the low voltage side can obtain the same effect.", "The circuit shown in FIG.", "17 may be used for each CNTV2.The dropped voltage must be above the lowest voltage which can hold the memory of the SRAM.", "FIG.", "25 shows the SRAM circuit of a third modification in which the SRAM circuit is divided into blocks and its power source control circuit part.", "They have four SRAM blocks SRAM1, SRAM2, SRAM3 and SRAM4, switches P9, P10, P11 and P12 constructed by the P channel type MOS transistor cutting off the power sources of the blocks, and a control circuit CNTS6 controlling the power switches.", "At the time of standby, the power source of the block which needs to hold data is not cut off and the power source of the block which need not hold data is cut off.", "In the circuit construction, the leakage current of the SRAM circuit is produced only in the blocks which must hold data.", "An example of the P channel type MOS transistor is described.", "As described already, the construction substituting it for the N channel type transistor is advantageous in area efficiency.", "In FIG.", "21, the block not cutting off the power source is provided and information of another block which must hold information and cuts off the power source at the time of standby is transferred.", "This construction need not transfer data.", "Means for detecting whether information must be held or not is added.", "The means cuts off only the power switch of the block which need not hold information.", "There is considered a control method of a control circuit CNTS6 in which the block into which necessary data is stored is stored and in the case of change to the standby state, the power source of the block in which no data is stored is cut off.", "In addition, there is considered a control method in which when making the circuit, the block cutting off the power source and the block not cutting off the power source are programmed to cut off the power source corresponding to the program.", "Further, there is considered a control method in which the power source of the block to be cut off during operation is programmed to cut off the power source of only the block which must cut off the power source.", "In this manner, change of the control methods of the control circuit CNTS6 can realize various power source cutting-off patterns.", "In FIG.", "26, the CNTV2 of FIG.", "24 is a switch connected to any one of three power source states.", "The three power source states refer to a state connected to the source voltage Vdd supplied from outside, a state connected to the power source having a voltage lower than the Vdd which can hold data in the SRAM, and a state cutting off the power source.", "When the CNTV2 can be connected to the three power source states, the power sources of all the blocks are connected to the Vdd in the active state, the power source of the block which must hold data is connected to the power source having a voltage lower than the Vdd in the standby state, and the power source of the block which need not hold data is cut off This can reduce the leakage current of the block which must hold data.", "The PDC in the drawing is a voltage dropping circuit and outputs a voltage lower than the power source Vdd in which the memory cell of the SRAM can hold data.", "In the circuit, corresponding to the value of the inputted control signal a cntpl, the switch is switched to connect the power source Vddm of the memory to the Vdd, the circuit dropping the voltage of the Vdd, or a state connected to nothing.", "Use of the circuit of FIG.", "25 can reduce the leakage current in the standby state.", "The power source of the SRAM block accessed in the active state is connected to the Vdd and the power source of the block not accessed is connected to the power source having a voltage lower than the Vdd.", "This can reduce the leakage current of the unnecessary SRAM block at the time of active.", "The CNTV2 can also be changed from the voltage dropping circuit to the voltage raising circuit, which can be inserted between the power line and the power source on the low voltage side of the memory cell.", "In FIG.S.", "24 and 25, the SRAM circuit is divided into four blocks As the circuit construction, it can be applied when there are one or more blocks.", "The MOS (Metal-Oxide-Semiconductor) transistor is described above.", "The MIS (Metal-Insulated-Semiconductor) transistor using no oxide film may be substituted.", "The same effect of the present invention is obtained.", "According to the present invention, the LSI consolidating the logic circuit and the SRAM circuit can reduce the power consumption at the time of standby." ] ]
Patent_15876132
[ [ "Interchangeable Shelf Label System", "An interchangeable shelf label system includes a label mount backing plate, a label sleeve, and a label plate for securing to shelving.", "The label mount backing plate has a configured thickness and extends from the distal end of one or more support arms of shelving and presents a front face as a backing surface for the label plate.", "The label sleeve includes ridges, extending inwardly from the interior front wall of the label sleeve a target width, with ridges disposed on opposing sides of the label sleeve.", "The label sleeve further includes ledges, opposing the ridges, the ledges disposed on opposing sides of the label sleeve.", "The ledges extend inwardly a target width from the ridges.", "The ledge to ridge area define a first sleeve dimensioned for receipt of the label mount backing plate.", "The ridge to interior wall area define an adjacent, second sleeve dimensioned for receipt of the label plate.", "The adjacent sleeve enables the label mount backing plate and the label plate to be simultaneously slidably engaged for an optimum compression fit." ], [ "1.A shelf label system for securing to shelving comprising: a label mount backing plate, a label sleeve, and a label plate; the label mount backing plate presenting a front face as a backing surface for the label plate, the label mount backing plate having a configured width for slidable engagement in the label sleeve; the label sleeve having an upper section, a lower section, a front section and a rear section; the label sleeve having ridges extending inwardly to the interior of the label sleeve a configured, target length; the label sleeve having ledges extending inwardly to the interior of the label sleeve, a configured, target length, the ledges opposing the ridges a configured, target width from the ridges; the ledge to ridge area defining a first sleeve dimensioned for receipt of the label mount backing plate and the ridge to interior wall area defining an adjacent second sleeve dimensioned for receipt of the label plate; the label plate including a display region and having a configured, target width; and the configured, target widths and material compositions of the label mount backing plate, the first sleeve, the label plate, and the second sleeve selected to result in a compression fit.", "2.The shelf label system of claim 1, wherein the rear of the label mount backing plate includes at least one protrusion dimensioned to be contained within a similarly positioned and dimensioned recess disposed on the label sleeve, whereby mating of the protrusion to recess joint resists relative sliding of the label sleeve.", "3.The shelf label system of claim 2, wherein the front section of the label sleeve includes an opening presenting a window.", "4.The shelf label system of claim 2, wherein the front section of the label sleeve is composed of a transparent material.", "5.The shelf label system of claim 2, wherein the label sleeve comprises an ultramid polyamide and the label plate comprises a polyvinylchloride.", "6.The shelf label system of claim 2, wherein the label mount backing plate comprises a glass-filled ultramid polyamide, the label sleeve comprises a glass-filled ultramid polyamide, and the label plate comprises a polyvinylchloride.", "7.The shelf label system of claim 1, wherein the rear of the label mount backing plate includes at least one recess dimensioned to be contained within a similarly positioned and dimensioned protrusion disposed on the label sleeve, whereby mating of the protrusion to recess joint resists relative sliding of the label sleeve.", "8.The shelf label system of claim 7, wherein the front section of the label sleeve includes an opening presenting a window.", "9.The shelf label system of claim 7, wherein the front section of the label sleeve is composed of a transparent material.", "10.The shelf label system of claim 7, wherein the label sleeve comprises an ultramid polyamide and the label plate comprises a polyvinylchloride.", "11.The shelf label system of claim 7, wherein the label mount backing plate comprises a glass-filled ultramid polyamide, the label sleeve comprises a glass-filled ultramid polyamide, and the label plate comprises a polyvinylchloride.", "12.A shelf label system for securing to shelving comprising: a label mount backing plate, a label sleeve, and a label plate; the label mount backing plate presenting a front face as a backing surface for the label plate, the label mount backing plate having a configured width for slidable engagement in the label sleeve; the label sleeve having an upper section, a lower section, a front section and a rear section; the label sleeve having ridges extending inwardly to the interior of the label sleeve a configured, target length; the label sleeve having ledges extending inwardly to the interior of the label sleeve, a configured, target length, the ledges opposing the ridges a configured, target width from the ridges; the ledge to ridge area defining a first sleeve dimensioned for receipt of the label mount backing plate and the ridge to interior wall area defining an adjacent second sleeve dimensioned for receipt of the label plate; the label plate including a display region and having a configured, target width; and the configured, target widths and material compositions of the label mount backing plate, the first sleeve, the label plate, and the second sleeve selected to result in a compression fit.", "13.The shelf label system of claim 12, wherein the front section of the label sleeve includes an opening presenting a window.", "14.The shelf label system of claim 12, wherein the label mount backing plate comprises a glass-filled ultramid polyamide, the label sleeve comprises a glass-filled ultramid polyamide, and the label plate comprises a polyvinylchloride.", "15.The shelf label system of claim 12, wherein the label plate includes one or more protrusions dimensioned to be contained within a similarly positioned and dimensioned recesses disposed on the front face of the label mount plate or front section of the label sleeve, such that mating of the protrusion to recess joint resists relative sliding of the label plate.", "16.The shelf label system of claim 12, wherein the front face of the label mount plate or front section of the label sleeve includes one or more protrusions dimensioned to be contained within similarly positioned and dimensioned recesses disposed on the label plate, such that mating of the protrusion to recess joint resists relative sliding of the label plate.", "17.A shelf label system for securing to shelving having a label mount backing plate presenting a front face and having a known width, the shelf label system comprising: a label sleeve, and a label plate; the label sleeve having an upper section, a lower section, a front section and a rear section; the label sleeve having ridges extending inwardly to the interior of the label sleeve a configured, target length; the label sleeve having ledges extending inwardly to the interior of the label sleeve, a configured, target length, the ledges opposing the ridges a configured, target width from the ridges; the ledge to ridge area defining a first sleeve dimensioned for receipt of the label mount backing plate and the ridge to interior wall area defining an adjacent second sleeve dimensioned for receipt of the label plate; the label plate including a display region and having a configured, target width; and the configured, target widths and material compositions of the label mount backing plate, the first sleeve, the label plate, and the second sleeve selected to result in a compression fit.", "18.The shelf label system of claim 17, wherein the front section of the label sleeve includes an opening presenting a window.", "19.The shelf label system of claim 17, wherein the label plate includes one or more protrusions dimensioned to be contained within a similarly positioned and dimensioned recesses disposed on the front face of the label mount plate or front section of the label sleeve, such that mating of the protrusion to recess joint resists relative sliding of the label plate.", "20.The shelf label system of claim 17, wherein the front face of the label mount plate or front section of the label sleeve includes one or more protrusions dimensioned to be contained within similarly positioned and dimensioned recesses disposed on the label plate, such that mating of the protrusion to recess joint resists relative sliding of the label plate." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>Embodiments of an interchangeable shelf label system include a label mount backing plate, a label sleeve, and a label plate for securing to shelving.", "The label mount backing plate extends from the distal end of one or more support arms, with the proximal ends of the support arms extending from shelving and the label mount backing plate presenting a front face as a backing surface for the label plate.", "The label mount backing plate has a configured thickness for slidable engagement in the label sleeve.", "The label sleeve includes an upper section, a lower section, a front section and a rear section.", "The label sleeve includes ridges, extending inwardly from the interior front wall of the label sleeve a configured target length, with the ridges disposed on opposing sides of the label sleeve.", "The label sleeve further includes ledges, opposing the ridges, the ledges disposed on opposing sides of the label sleeve.", "The ledges extend inwardly a configured target distance from the ridges.", "The ledge to ridge area define a first sleeve dimensioned for receipt of the label mount backing plate.", "The ridge to interior wall area define an adjacent, second sleeve dimensioned for receipt of the label plate.", "The adjacent sleeve enable the label mount backing plate and the label plate to be simultaneously slidably engaged.", "The label plate has a configured thickness.", "The configured target dimensions and material compositions of the label mount backing plate, first sleeve, label plate, and the second sleeve are selected to result in an optimum compression fit such that the label plate can be slidably engaged and disengaged by hand force while preventing accidental dislodging.", "These and other features, aspects, and advantages of the invention will become better understood with reference to the following description, and accompanying drawings." ], [ "BACKGROUND Field of the Invention The invention relates generally to shelf systems and more particularly to shelf display systems.", "Description of the Related Art In the merchandising of products in stores, merchandise is often displayed on shelves, where the items can be easily seen by customers and easily removed for placement in shopping carts or the like.", "It is conventional to secure label display stickers to the front of such shelves, to display pricing information and/or other information of relevance to a prospective consumer.", "Often, the retailer desires to highlight certain items in a manner that will catch the consumer's attention.", "Typical methods of highlighting selected products involve attaching adhesive labels to the front of the label holder with the information on the label facing a consumer as he or she walks along a store aisle, such as that shown in the prior art FIG.", "9.An example display structure includes shelf-type structures having shelf-type price label holders such as that shown in the prior art figure.", "The rear end is slid through a channel and a sticker with the display information is placed on the front face.", "When it is necessary to change product information, the sticker is removed from the front face, taking time and energy.", "SUMMARY Embodiments of an interchangeable shelf label system include a label mount backing plate, a label sleeve, and a label plate for securing to shelving.", "The label mount backing plate extends from the distal end of one or more support arms, with the proximal ends of the support arms extending from shelving and the label mount backing plate presenting a front face as a backing surface for the label plate.", "The label mount backing plate has a configured thickness for slidable engagement in the label sleeve.", "The label sleeve includes an upper section, a lower section, a front section and a rear section.", "The label sleeve includes ridges, extending inwardly from the interior front wall of the label sleeve a configured target length, with the ridges disposed on opposing sides of the label sleeve.", "The label sleeve further includes ledges, opposing the ridges, the ledges disposed on opposing sides of the label sleeve.", "The ledges extend inwardly a configured target distance from the ridges.", "The ledge to ridge area define a first sleeve dimensioned for receipt of the label mount backing plate.", "The ridge to interior wall area define an adjacent, second sleeve dimensioned for receipt of the label plate.", "The adjacent sleeve enable the label mount backing plate and the label plate to be simultaneously slidably engaged.", "The label plate has a configured thickness.", "The configured target dimensions and material compositions of the label mount backing plate, first sleeve, label plate, and the second sleeve are selected to result in an optimum compression fit such that the label plate can be slidably engaged and disengaged by hand force while preventing accidental dislodging.", "These and other features, aspects, and advantages of the invention will become better understood with reference to the following description, and accompanying drawings.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 depicts an embodiment of an interchangeable shelf label system as it may exist in operation; FIG.", "2 depicts the parts of an embodiment of an interchangeable shelf label system as it may exist in operation; FIG.", "3 depicts a top view of parts of an embodiment of an interchangeable shelf label system as it may exist in operation; FIGS.", "4A and 4B depict top views of parts of embodiments of interchangeable shelf label systems as they may exist in operation; FIGS.", "5A and 5B depict front perspective views of usage of embodiments of interchangeable shelf label systems as they may exist in operation; FIGS.", "6A and 6B depict front perspective views of usage of embodiments of interchangeable shelf label systems as they may exist in operation; FIGS.", "7A and 7B depict front perspective views of usage of embodiments of interchangeable shelf label systems as they may exist in operation; FIG.", "8 depicts a top perspective view of an embodiment of an interchangeable shelf label system as it may exist in operation; and FIG.", "9 depicts a prior art shelf label display.", "DETAILED DESCRIPTION Detailed descriptions of the preferred embodiment are provided herein.", "It is to be understood, however, that the present invention may be embodied in various forms.", "Therefore, specific details disclosed herein are not to be interpreted as limiting, but rather as a basis for the claims and as a representative basis for teaching one skilled in the art to employ the present invention in virtually any appropriately detailed system, structure or manner.", "As mentioned, it is conventional to secure label display strips to the front of display shelves, to receive and display pricing and other information of relevance to a prospective consumer.", "Often the retailer desires to highlight certain merchandise in a manner that will catch the consumer's attention.", "Additionally, a retailer often seeks high turnover frequency of the shelf space, with the ability to quickly and uniquely label all sections of the shelf space is desirable.", "A consistent problem with the use of conventional labels arises after the label has served its purpose and is no longer needed.", "The present invention is directed to an interchangeable shelf label system 10.FIG.", "1 illustrates an embodiment of an interchangeable shelf label system 10 of the present invention as it may exist in usage.", "Depicted are a label backing plate 12, a label sleeve 20, and a label plate 30.Certain embodiments of the invention include a label mount backing plate 12, operable to support the interchangeable shelf label system 10 and provide a backing support surface for the label plate 30.FIGS.", "2 and 3 illustrate configurations of a label mount backing plate 12.The illustrated label mount backing plate 12 extends from the distal end of one or more support arms 16, with the proximal ends of the support arms 16 extending from shelving 08.The label mount backing plate 12 includes a front face and a rear face.", "The illustrated label mount backing plate 12 presents a front face 15 having a surface area presenting a backing surface for the label plate 30, conforming to at least a portion of the rear surface of the label plate 30.An exemplary front face 15 is substantially planar.", "The label mount backing plate 12 can angularly depend from the support arms 16, with representative suitable angles being about 70° to 100° relative to the support arms 16.The label mount backing plate 12 has a configured thickness W1 for slidable engagement into the label sleeve 20, as will be disclosed.", "FIG.", "3 illustrates a configuration of a label sleeve 20.The label sleeve 20 is operable is to slidably receive the label mount backing plate 12 and the label plate 30 simultaneously in order to resiliently secure the interchangeable shelf label system 10, employing a compression fit approach, in exemplary configuration.", "The label sleeve 20 is composed of rigid materials, including plastics and polymers, such as rigid polyvinyl chloride, ultramid polyamide, glass-filled ultramid polyamide, or others.", "The label sleeve 20 includes an upper section 21 and a lower section 19.The label sleeve 20 includes a front section 31 and a rear section 25.In certain configurations, the front section 31 of the label sleeve 20 includes an opening presenting a window 29.In certain configurations, the label sleeve 20 or the front section 31 is composed of a transparent material, such as a polymer or plastic.", "The window 29 or transparency enable visibility of the insignia 34 region while the device is in operation, such that the front face 32 or section thereof can be clearly viewed.", "The illustrated label sleeve 20 of FIG.", "4A includes ridges 24 extending from the upper section 21 of the label sleeve 20 to the lower section 19 of the label sleeve 20, the ridges 24 disposed on opposing sides of the label sleeve 20.In other configurations, the ridges 24 have a shorter height, not extending from the upper section 21 to the lower section 19.The ridges 24 extend inwardly from the interior front wall of the label sleeve 20 a length of W3.The illustrated label sleeve 20 also includes ledges 28 extending from the upper section 21 of the label sleeve 20 to the lower section 19 of the label sleeve 20, the ledges 28 disposed on opposing sides of the label sleeve 20.In other configurations, the ledges 28 have a shorter height, not extending from the upper section 21 to the lower section 19.The ledges 28 are further distal to the ridges 24 from the interior front wall and also extend inwardly a distance of W2 from the ridges 24.The area bounded laterally by the ledge 24 to ridge 28 on the same side of the label sleeve 20, from opposing ledges 24, and from opposing ridges 28 define a first sleeve 22.This first sleeve 21 is dimensioned for receipt of the label mount backing plate 12.The area bounded laterally by the interior wall and the end of the opposing ridges 28 define an adjacent, second sleeve 26.This second sleeve 26 is dimensioned for receipt of the label plate 30.FIG.", "2 illustrates configurations of a label plate 30.The label plate 30 is composed of rigid materials, including plastics and polymers, such as rigid polyvinyl chloride, ultramid polyamide, glass-filled ultramid polyamide, or others, and is operable to display the product information on the proximate shelving 08.The label plate 30 includes a front face 32 and a display region 34.It has a thickness W4.The display region 34 can receive a printable medium such as thin gauge printable sheet material, sticker labels, paper, cardstock, paper board, or other similar printable medium, that is printed with textual and/or graphical indicia including generalized information relating to a number of particular items being displayed on the shelf 08 to which interchangeable shelf label system 10 is attached, such as indicia indicative of brand identification, graphical designs and the like.", "In other configurations, it may serve as a printable medium, where it can be printed or screened upon.", "As disclosed, embodiments of the present invention employ compression fit in the interchangeable label mount system 10, where the front face 32 of the label plate 30 contacts the interior wall of the label sleeve 20, the rear face of the label plate 30 contacts the front face 14 of the label mount backing plate 12, the front face 14 of the label mount backing plate 12 also contacts the ridges 24, and the rear face of the label mount backing plate 12 contacts the ledges 28.The compression of the label mount backing plate 12 and the label plate 30 within the interior of the label sleeve 20 secures the interchangeable label mount system 10 in operation (FIG.", "5B).", "The first sleeve 22 contains the mount backing plate 12 while the second sleeve 26 contains the label plate 30.The compression is configured with a target resistance force that allows repositioning of the label plate 30 by sliding it laterally and also allows removal when necessary or desired but at the same time effectively prevents accidental dislodging of the label plate 30.In exemplary configuration, the interchangeable label mount system 10 is configured such that the label plate 30 can be removed by a user using thumbs and applying upward force to dislodge the label plate 30 for changing (FIG.", "5A).", "The embodiments of FIGS.", "4B, 6A, 6B, 7A, and 7B include at least one protrusion 18 to recess 38 pair, with the protrusions 18 dimensioned to be contained within a similarly positioned and dimensioned corresponding recess 38.A protrusion 18 fits within its corresponding recess 38 such that the mating of the protrusion 18/recess 38 locks the relative position of the label plate 30 to the label sleeve 20, resisting relative sliding of the label plate 30.The protrusion 18/recess 38 pairs can take different geometries and dimensions for different pairing characteristics.", "For example, protrusion 18′ takes a hemispherical geometry, providing a relatively similar lodging and dislodging force locking characteristic.", "For example, protrusion 18″ takes an inverse triangular geometry, requiring a strong dislodging force locking characteristic.", "The protrusions 18 and recesses 38 can have various dispositions.", "In the illustrated embodiments, the label plate 30 includes one or more protrusions 18 dimensioned to be contained within the similarly positioned and dimensioned recess(es) 38 disposed on the front face 14 of the label mount plate 12 or front section 31 of the label sleeve 20, such that mating of the protrusion 18/recess 38 lock resists relative sliding of the label plate 30.In other configurations, the front face 14 of the label mount plate 12 or front section 31 of the label sleeve 20 includes one or more protrusions 18 dimensioned to be contained within similarly positioned and dimensioned recess(es) 38 disposed on the label plate 30, such that mating of the protrusion 18/recess 38 lock resists relative sliding of the label plate 30.Referring to FIG.", "3, the target configuration factors include the dimensions W1, W2, W3, and W4 and the material composition of the label sleeve 20, the label mount backing plate, and the label mount backing plate 12.Regarding the dimensions, the proportion of the values relative to each other and/or the total width can alter the target resistance or “snugness” of the fit.", "Regarding the material composition, materials with an optimum coefficient of friction are selected.", "Below are implementations for one configuration.", "Again, it should be appreciated that the dimension values are proportional and can be scaled for other environments.", "Width Composition Label Mount 3.2 mm Glass-filled Backing Plate ultramid Thickness (W1) polyamide First Sleeve (W2) 3.2 mm Glass-filled ultramid polyamide Label Plate 1.2 mm polyvinylchloride Thickness (W4) Second Sleeve (W3) 1.5 mm Glass-filled ultramid polyamide Another configuration employed the following: Width Composition Label Mount 2.5 mm Glass-filled ultramid polyamide Backing Plate Thickness (W1) First Sleeve (W2) 2.5 mm Glass-filled ultramid polyamide Label Plate 1.0 mm polyvinylchloride Thickness (W4) Second Sleeve 1.0 mm Glass-filled ultramid polyamide (W3) FIGS.", "2, 5A, 5B, and 8 illustrate usage of an interchangeable shelf label system 10.The label mount backing plate 12, the label sleeve 20, and the label plate are brought in proximity and aligned (FIG.", "2).", "The label sleeve 20 is slidably engaged to the label mount backing plate 12 such that the label mount backing plate 12 occupies the first sleeve 21 (FIG.", "5A).", "The label plate 20 is slidably engaged to the label sleeve 20 such that the label plate 20 occupies the second sleeve 26 (FIG.", "5B).", "Completely slidably engaging the label plate 30 leaves the interchangeable label mount system 10 as it would exist in shelf label display usage (FIG.", "1).", "Insofar as the description above and the accompanying drawing disclose any additional subject matter that is not within the scope of the single claim below, the inventions are not dedicated to the public and the right to file one or more applications to claim such additional inventions is reserved." ] ]
Patent_15876133
[ [ "Packaged Overvoltage Protection Circuit For Triggering Thyristors", "In a first embodiment, an ultra-fast breakover diode has a turn on time TON that is less than 0.3 microseconds, where the forward breakover voltage is greater than +400 volts and varies less than one percent per ten degrees Celsius change.", "In a second embodiment, a breakover diode has a reverse breakdown voltage that is greater, in absolute magnitude, than the forward breakover voltage, where the forward breakover voltage is greater than +400 volts.", "In a third embodiment, a string of series-connected breakover diode dice is provided, along with a resistor string, in a packaged circuit.", "The packaged circuit acts like a single breakover diode having a large forward breakover voltage and a comparably large reverse breakdown voltage, even though the packaged circuit includes no discrete high voltage reverse breakdown diode.", "The packaged circuit is usable to supply a triggering current to a thyristor in a voltage protection circuit." ], [ "1.A packaged overvoltage protection circuit comprising: a first semiconductor die, wherein the first semiconductor die comprises a breakover diode having a reverse breakdown voltage of at least four hundred volts; a second semiconductor die, wherein the second semiconductor die comprises a breakover diode having a reverse breakdown voltage of at least four hundred volts; a package housing that encloses the first and second semiconductor dice; a first package terminal; and a second package terminal, wherein the first and second semiconductor dice are coupled such that if a positive voltage of adequate magnitude is present between the second package terminal and the first package terminal then breakover of the breakover diodes in the first and second semiconductor dice occurs and a current flows in a current path from the second package terminal, through the breakover diode of the first semiconductor die, through the breakover diode of the second semiconductor die, and to the first package terminal, and such that if a negative voltage of nine hundred volts or less is present between the second package terminal and the first package terminal then neither of the breakover diodes of the first and second semiconductor dice suffers reverse breakdown.", "2.The packaged overvoltage protection circuit of claim 1, wherein the packaged overvoltage protection circuit has no package terminal other than the first and second package terminals.", "3.The packaged overvoltage protection circuit of claim 2, wherein the package housing encloses no semiconductor die that comprises any component other than a breakover diode.", "4.The packaged overvoltage protection circuit of claim 2, wherein the package housing encloses no diode that is not a part of a breakover diode die.", "5.The packaged overvoltage protection circuit of claim 2, further comprising: a third semiconductor die, wherein the third semiconductor die comprises a breakover diode having a reverse breakdown voltage of at least four hundred volts.", "6.The packaged overvoltage protection circuit of claim 2, further comprising: a first resistor; and a second resistor, wherein the first and second resistors are coupled in series.", "7.The packaged overvoltage protection circuit of claim 2, further comprising: a first resistor coupled in parallel with the first semiconductor die; and a second resistor coupled in parallel with the second semiconductor die.", "8.The packaged overvoltage protection circuit of claim 2, wherein the first and second semiconductor dice are coupled to block current flow through the current path from the first package terminal to the second package terminal for reverse voltages of nine hundred volts or less.", "9.A packaged overvoltage protection circuit comprising: a first package terminal; a second package terminal; a plurality of semiconductor dice, wherein each of the semiconductor dice comprises a breakover diode, wherein the breakover diode has a forward breakover voltage, wherein the breakover diode has a reverse breakdown voltage whose absolute magnitude is greater than the forward breakover voltage, wherein the plurality of semiconductor dice are coupled in series between the first and second package terminals, and wherein the breakover voltage is at least four hundred volts; a plurality of resistors, wherein the resistors are coupled in series; and a package housing that encloses the plurality of semiconductor dice and the plurality of resistors, wherein the package housing encloses no semiconductor die other than said plurality of semiconductor dice.", "10.The packaged overvoltage protection circuit of claim 9, wherein each of the plurality of semiconductor dice is substantially identical to each other of the plurality of semiconductor dice, and wherein the packaged overvoltage protection circuit has no package terminal other than the first and second package terminals.", "11.The packaged overvoltage protection circuit of claim 9, wherein each of the plurality of resistors is coupled in parallel with each corresponding respective one of the plurality of semiconductor dice.", "12.An apparatus comprising: a first package terminal; a second package terminal; and means for blocking substantially all current flow from the second package terminal to the first package terminal for positive voltages less than a first voltage between the second and first package terminals, for initiating conduction of a breakover current from the second package terminal to the first package terminal if a positive voltage equal to the first voltage becomes present between the second and first package terminals, and for blocking substantially all current flow from the first package terminal to the second package terminal for negative voltages less than a second voltage between the second package terminal and the first package terminal, wherein the absolute magnitude of the second voltage exceeds the first voltage, wherein the first voltage is at least nine hundred volts, wherein the means comprises no semiconductor die other than a plurality of semiconductor dice, and wherein each die of the plurality of semiconductor dice comprises a breakover diode.", "13.The apparatus of claim 12, wherein the plurality of semiconductor dice are coupled together in series between the first and second package terminals.", "14.The apparatus of claim 13, wherein the means further comprises a plurality of resistors coupled together in series to form a resistor string.", "15.The apparatus of claim 14, wherein the means further comprises a housing that encloses the plurality of semiconductor dice and the plurality of resistors.", "16.The apparatus of claim 15, wherein the means does not block current flow that passes through the resistor string.", "17.The apparatus of claim 12, wherein the means is also for supplying a triggering current to the gate of a thyristor.", "18.The apparatus of claim 12, further comprising: a thyristor having a gate, an anode, and a cathode, wherein the gate of the thyristor is coupled to the first package terminal.", "19.The apparatus of claim 12, further comprising: a thyristor having a gate, an anode, and a cathode, wherein the gate of the thyristor is coupled to the first package terminal, wherein the anode of the thyristor is coupled to the second package terminal via a current limiting resistor.", "20.The apparatus of claim 18, further comprising: a snubber circuit coupled between the gate of the thyristor and the cathode of the thyristor." ], [ "<SOH> BACKGROUND INFORMATION <EOH>FIG.", "1 (Prior Art) is a symbol of a thyristor 1 .", "A conventional thyristor is a three terminal semiconductor device that has four layers of alternating N type material and P type material.", "FIG.", "2 (Prior Art) shows an example in which the thyristor device 1 has an P-N-P-N structure.", "A cathode electrode 2 is coupled to the N type material on one side of the device and an anode electrode 3 is coupled to the P type material on the other side of the device.", "A gate electrode 4 is coupled to the P type layer closest to the cathode.", "The structure has three PN junctions, serially named J 1 , J 2 , and J 3 , from the anode electrode side of the device.", "Operation of the thyristor device is explained in terms of a pair of tightly coupled bipolar junction transistors, arranged in a self-latching way, as illustrated in FIG.", "3 (Prior Art).", "One bipolar transistor 5 is an NPN transistor whose N type emitter is coupled to the cathode electrode.", "The other bipolar transistor 6 is a PNP transistor whose P type emitter is coupled to the anode electrode.", "The thyristor is considered to operate in one of three modes: 1) in a reverse blocking mode, 2) in a forward blocking mode, and 3) in a forward conducting mode.", "If the cathode electrode has a positive voltage with respect to the anode electrode, then no current flows from cathode to anode because either the J 3 junction and/or the J 1 junction is reverse biased.", "These two PN junctions can be thought of as a series connected pair of diodes that are reverse biased.", "This is referred to as the reverse blocking mode.", "Supplying a triggering pulse into the gate has no effect.", "If the anode has a positive voltage with respect to the cathode, but no voltage is applied to the gate electrode with respect to the cathode electrode, then the J 1 and J 3 junctions are forward biased, while the J 2 junction is reverse biased.", "Due to the J 2 junction being reverse biased, there is no conduction and the thyristor is off.", "This is referred to as the forward blocking mode.", "The anode-to-cathode voltage is applied in a direction that could cause conduction were there to be current flow across the J 2 junction, but the thyristor has not been triggered.", "At some voltage, the electric field at the J 2 junction grows so strong that the J 2 junction starts to breakdown and a small amount of avalanche current begins to flow, but the amount of current is not adequate to turn on transistor 5 .", "If the anode-to-cathode voltage is increased beyond the forward breakdown voltage V (BO)F of the thyristor, then the magnitude of the avalanche current reaches a triggering current, which causes transistor 5 to turn on, and causes the thyristor to start conducting.", "This is referred to as the forward conduction mode.", "If a positive voltage is applied to the gate electrode with respect to the cathode electrode, then the onset of this avalanche breakdown of the J 2 junction occurs at a lower (but still positive) anode-to-cathode voltage.", "The anode-to-cathode voltage at which the thyristor turns on is therefore dependent upon the gate voltage (gate-to-cathode voltage).", "This positive gate voltage that causes the thyristor to turn on (due to avalanche breakdown of the J 2 junction) can be caused by injecting a momentary current pulse 7 into the gate electrode 4 .", "Whether the triggering on is said to occur due to the gate voltage pulse or due to the current of the pulse, the triggering effect of triggering the thyristor on is the same in that avalanche breakdown of the J 2 junction is started.", "Once avalanche breakdown of the J 2 junction has occurred and the thyristor is on and conducting current from the anode to the cathode, the thyristor remains latched in this on state and the thyristor continues to conduct, irrespective of changes in the gate voltage, until either the anode is no longer forward biased with respect to the cathode, or until the current through the thyristor (anode to cathode) is less than a holding current I H .", "Once the thyristor has been triggered, removing the triggering current does not turn off the thyristor.", "If the anode is positively biased with respect to the cathode, then the thyristor cannot be turned off unless the anode current falls below the holding current I H .", "The thyristor can, however, be switched off if an external circuit momentarily causes the anode to be negatively biased with respect to the cathode.", "Very large and expensive thyristors are used to switch high voltages in high power applications.", "Due to the limited maximum forward voltage drop (anode to cathode) that can be put across a thyristor before it conducts too much current and fails, many thyristors are typically assembled together in series in what is referred to as a stack.", "Each thyristor of the stack therefore only has to handle part of the overall high forward voltage drop across the stack.", "By controlling the gate voltages of the individual thyristors in the stack, the stack can be made to operate as a single high voltage and high power switch that either conducts from one end of the stack to the other, or that does not conduct.", "Thyristor stacks are, for example, used in megawatt scale AC-to-DC and DC-to-AC power conversion, such as for example where the high DC voltage is a voltage on a high voltage DC power transmission line.", "If the magnitude of the high voltage DC were to momentarily pulse high, such as due to the power line being struck by lightning, then an intolerably high transient voltage might be momentarily placed across the thyristor stack (the anode voltage is at too high a positive voltage with respect to the cathode), causing excessive current flow through the stack if the thyristors were on, and causing localized overheating and failure of the stack.", "To avoid this, and to protect the thyristors of the stack from such a transient overvoltage condition, an overvoltage protection device referred to as a BOD (Break Over Diode) device is used.", "BOD devices are coupled to the thyristors of the stack in such a way that the BOD devices turns on the thyristors before excessive over voltage across the thyristors can damage the thyristors.", "The BOD overvoltage protection device detects the high voltage condition and turns on, thereby causing a gate current to flow into the gate of each thyristor, and thereby turning on the thyristor.", "A BOD diode is a thyristor whose gate electrode is not brought out of the device for external connection.", "The BOD diode has an anode electrode and a cathode electrode, but the gate electrode of the device is not brought out.", "The BOD diode is not triggered on by an externally applied pulse of gate current as described above in the case of a conventional thyristor, but rather the BOD diode is triggered on by the onset of avalanche current that is generated within the BOD device itself.", "Operation of the BOD diode is therefore explained using the terminology employed above in connection with the self-latching bipolar transistor structure of FIG.", "3 .", "In a forward blocking mode, as the anode-to-cathode voltage increases to the V (BO)F , the J 1 and J 3 junctions are forward biased but the J 2 junction is reversed biased.", "A depletion region forms at this reverse biased J 2 junction, and the resulting separation of charge at the junction gives rise to a localized electric field.", "The strength of the electric field grows to the point that covalent bonds of the material at the J 2 junction are broken, and an avalanche current flows, with generated electrons being pulled to the relative positive potential of the anode, and with generated holes being pulled the opposite direction to the relative negative potential of the cathode.", "The hole flow through the P type layer between J 2 and J 3 results in a voltage drop across the material of the P type layer.", "If the avalanche current is of adequate magnitude, then the voltage drop exceeds 0.7 volts, resulting in the base-to-emitter voltage of the NPN transistor 5 (see FIG.", "3 ) exceeding 0.7 volts.", "This causes the NPN transistor 5 to turn on.", "The NPN transistor 5 turning on pulls a base current out of the base of the PNP transistor 6 .", "PNP transistor 6 turns on, and supplies current from its collector into the base of the NPN transistor 5 .", "The two transistors are therefore latched on in a self-latching way, with each one supplying a base current to the other.", "Once the BOD diode has triggered itself on in this way, it will remain on unless either the anode is no longer forward biased with respect to the cathode, or until the current through the BOD diode falls below the holding current I H .", "In an overvoltage protection application, the BOD diode is coupled in parallel with a power thyristor of a stack, such that if an excessive forward voltage develops across the power thyristor, then the BOD diode undergoes breakover and turns on, thereby conducting a current.", "This current is supplied as a triggering pulse to the thyristor, so that the thyristor is turned on.", "Accordingly, when the forward voltage across the thyristor reaches an adequately high voltage, the breakover diode supplies a triggering current to the thyristor and causes the thyristor to turn on.", "When the thyristor turns on, the forward voltage drop across the thyristor decreases.", "The thyristor is therefore protected from an over voltage condition.", "FIG.", "4 (Prior Art) is a cross-sectional diagram of a conventional bulk BOD diode 8 .", "The PNPN thyristor structure is evident.", "Whereas the anode electrode 3 of the PNPN structure of FIG.", "2 is illustrated on the top, the anode electrode 9 of the BOD diode of FIG.", "4 is illustrated on the bottom.", "The P type substrate layer 10 is the first P type thyristor layer, the N− type substrate layer 11 is the second N type thyristor layer, the P type base region 12 is the third P type thyristor layer, and the N+ type region 13 is the fourth N type thyristor layer.", "Layers 10 and 11 are both of substrate silicon, so the BOD is referred to here as a “bulk” BOD.", "Reference numeral 14 identifies the cathode electrode.", "The BOD device has guard rings 15 and 16 , and a peripheral shallow channel stopper 17 .", "FIG.", "5 (Prior Art) is a diagram that shows the electric field along line A-A′ in FIG.", "4 just before the onset of avalanche breakdown.", "The peak of the electric field is at the J 2 PN junction.", "The J 2 PN junction is between the N− type base layer 11 and the P type base region 12 .", "When the electric field strength at this point is high enough, then the avalanche current begins to flow.", "If the magnitude of current flow from the junction laterally under the emitter region 13 across the resistance of the P type material of region 12 and to the cathode electrode 14 is adequately high, then the resulting voltage drop will reach 0.7 volts.", "This 0.7 volt drop amounts to a 0.7 base-to-emitter voltage on the NPN transistor, so the thyristor will be triggered on as described above.", "FIG.", "6 (Prior Art) is a diagram that shows the turning on of the BOD device 8 of FIG.", "4 .", "The BOD device has 8 has a reverse breakdown voltage of −200 volts to −300 volts.", "In the forward voltage condition, the solid line 18 in FIG.", "6 represents current flow through the BOD device from anode to cathode.", "The dashed line 19 is the anode-to-cathode voltage across the BOD device.", "As can be seen, the BOD device begins to conduct appreciable current at a forward anode-to-cathode breakover voltage V (BO)F of about +450 volts.", "This is the time when the avalanche current in the BOD device has reached the triggering current.", "Thereafter the current increases and the voltage across the BOD device decreases.", "At time 0.6 microseconds the anode-to-cathode voltage across the BOD device has decreased to zero volts.", "The turn on time (T ON ) is the time from the time when the internal triggering current is reached at time 0.1 microseconds until the time when the anode-to-cathode voltage reaches zero volts.", "The turn on time (T ON ) is therefore 0.5 microseconds.", "Because a high transient overvoltage condition can cause a power thyristor of a stack to be destroyed in a short amount of time, a fast turn on BOD is desired for its thyristor-protection function." ], [ "<SOH> SUMMARY <EOH>In a first novel aspect, an ultra-fast breakover diode has a turn on time T ON of less than 0.3 microseconds, a breakover voltage greater than +400 volts, and the breakover voltage varies less than one percent per ten degree Celsius change.", "The breakover voltage is also repeatable over changes in semiconductor manufacturing process.", "In one example, an anode metal electrode is disposed on a bottom surface of a P type layer of substrate semiconductor material, and an N type buffer layer of epitaxial semiconductor material is disposed on the P type layer.", "The N type buffer layer has an N type dopant concentration between 1×10 15 atoms/cm 3 and 1×10 16 atoms/cm 3 .", "A thin layer of N− type base layer of epitaxial semiconductor material is disposed on the N type buffer layer.", "This thin layer is less than 130 microns thick.", "A P type base region extends from a semiconductor surface down into the thin N− type base layer to a depth D. The P type base region has a peripheral edge at the semiconductor surface, and the peripheral edge has a minimum radius of curvature R that is at least twice the depth D. An N+ type annular emitter region extends down from the semiconductor surface down into the P type base region such that material of the P type base region extends up to the semiconductor surface in the center of the N+ annular region and defines a cathode short region of P type semiconductor material.", "The cathode short region has a width at the semiconductor surface that is less than 0.250 millimeters.", "A cathode metal electrode is disposed over part of the annular N+ type emitter and over the cathode short region at the semiconductor surface.", "A floating metal ring is disposed on the P type base region.", "In a second novel aspect, a high voltage breakover diode has comparable forward breakover and reverse breakdown voltages.", "In one example, an anode metal electrode is disposed on a bottom semiconductor surface of a P type layer of substrate semiconductor material.", "An N− type base layer is disposed on the P type layer, and a P type base region extends from an upper semiconductor surface down into the N-type base layer.", "An N+ type annular emitter region extends down from the upper semiconductor surface into the P type base region.", "P type material of the P type base region extends up to the semiconductor surface in the center of the annular emitter region and defines a cathode short region.", "A P type isolation diffusion region extends from the upper semiconductor surface to the bottom semiconductor surface, and the P type isolation diffusion region surrounds the N− type base layer in the lateral dimension so that the P type isolation diffusion contacts each of four side edges of the die of breakover diode device.", "A cathode metal electrode is disposed over part of the annular N+ type emitter and over the cathode short region at the upper semiconductor surface.", "The breakover diode device has a forward breakover voltage (V (BO)F ) that is greater than four hundred volts.", "The breakover diode device is also able to withstand a reverse voltage whose absolute value is in excess of the forward breakover voltage without suffering breakdown.", "In a third novel aspect, a packaged overvoltage protection circuit includes a plurality of identical breakover diode dice, and a plurality of resistors.", "The plurality of breakover diode dice are coupled together in series between a first package terminal and a second package terminal.", "The plurality of resistors are coupled together in a resistor string, such that one resistor is in parallel with each of the plurality of breakover diode dice.", "The plurality of breakover diode dice and the plurality of resistors are enclosed in a package housing from which the first and second package terminals extend.", "Each of the breakover diodes has a reverse breakdown voltage that is greater in absolute magnitude than the forward breakover voltage of the breakover diode, and the forward breakover voltage is at least 400 volts.", "Of importance, the packaged overvoltage protection circuit need contain no expensive separate discrete diode with a high reverse breakdown capability.", "The only semiconductor components of the packaged overvoltage protection circuit are the plurality of breakover diode dice.", "Accordingly, the package housing encloses no semiconductor die that comprises any component other than a breakover diode.", "In one application, the packaged overvoltage protection circuit is usable to supply a triggering current to the gate of a thyristor.", "If the voltage between the anode and the cathode of the thyristor exceeds a first positive voltage, then the breakover diodes in the packaged overvoltage protection circuit will undergo breakover such that a triggering current is supplied from the packaged overvoltage protection circuit and into the gate of the thyristor.", "The triggering current turns the thyristor on, and the thyristor conducts a large current to reduce the voltage across the thyristor between the anode and cathode to be less than the first positive voltage.", "A large negative voltage between the gate of the thyristor and the anode of the thyristor will not damage the packaged overvoltage protection circuit because the packaged overvoltage protection circuit can withstand a reverse voltage of a second voltage.", "The second voltage is a large negative voltage that has an absolute value that is greater than the first positive voltage.", "The number of breakover diode dice in series can be increased to increase the first and second voltages.", "In one example, the first voltage is +8000 volts, and the second voltage is −10,000 volts.", "In one example, a snubber circuit is provided between the gate and cathode of the thyristor to soften ill effects of switching voltage spikes on the packaged overvoltage protection circuit.", "A current limiting resistor is placed in series with the packaged overvoltage protection circuit between the thyristor anode and the thyristor gate to limit the magnitude of the triggering current.", "A second identical circuit (packaged overvoltage protection circuit, thyristor, current limiting resistor, and snubber circuit) is provided in parallel with the first circuit to protect against large negative voltages that are more negative than −8000 volts.", "Further details and embodiments and techniques are described in the detailed description below.", "This summary does not purport to define the invention.", "The invention is defined by the claims." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of, and claims priority under 35 U.S.C.", "§ 120 from, nonprovisional U.S. patent application Ser.", "No.", "13/892,237 entitled “Packaged Overvoltage Protection Circuit For Triggering Thyristors,” filed on May 10, 2013, now U.S. Patent No.", "______ , the subject matter of which is incorporated herein by reference.", "TECHNICAL FIELD The described embodiments relate to breakover diodes and to related structures and methods.", "BACKGROUND INFORMATION FIG.", "1 (Prior Art) is a symbol of a thyristor 1.A conventional thyristor is a three terminal semiconductor device that has four layers of alternating N type material and P type material.", "FIG.", "2 (Prior Art) shows an example in which the thyristor device 1 has an P-N-P-N structure.", "A cathode electrode 2 is coupled to the N type material on one side of the device and an anode electrode 3 is coupled to the P type material on the other side of the device.", "A gate electrode 4 is coupled to the P type layer closest to the cathode.", "The structure has three PN junctions, serially named J1, J2, and J3, from the anode electrode side of the device.", "Operation of the thyristor device is explained in terms of a pair of tightly coupled bipolar junction transistors, arranged in a self-latching way, as illustrated in FIG.", "3 (Prior Art).", "One bipolar transistor 5 is an NPN transistor whose N type emitter is coupled to the cathode electrode.", "The other bipolar transistor 6 is a PNP transistor whose P type emitter is coupled to the anode electrode.", "The thyristor is considered to operate in one of three modes: 1) in a reverse blocking mode, 2) in a forward blocking mode, and 3) in a forward conducting mode.", "If the cathode electrode has a positive voltage with respect to the anode electrode, then no current flows from cathode to anode because either the J3 junction and/or the J1 junction is reverse biased.", "These two PN junctions can be thought of as a series connected pair of diodes that are reverse biased.", "This is referred to as the reverse blocking mode.", "Supplying a triggering pulse into the gate has no effect.", "If the anode has a positive voltage with respect to the cathode, but no voltage is applied to the gate electrode with respect to the cathode electrode, then the J1 and J3 junctions are forward biased, while the J2 junction is reverse biased.", "Due to the J2 junction being reverse biased, there is no conduction and the thyristor is off.", "This is referred to as the forward blocking mode.", "The anode-to-cathode voltage is applied in a direction that could cause conduction were there to be current flow across the J2 junction, but the thyristor has not been triggered.", "At some voltage, the electric field at the J2 junction grows so strong that the J2 junction starts to breakdown and a small amount of avalanche current begins to flow, but the amount of current is not adequate to turn on transistor 5.If the anode-to-cathode voltage is increased beyond the forward breakdown voltage V(BO)F of the thyristor, then the magnitude of the avalanche current reaches a triggering current, which causes transistor 5 to turn on, and causes the thyristor to start conducting.", "This is referred to as the forward conduction mode.", "If a positive voltage is applied to the gate electrode with respect to the cathode electrode, then the onset of this avalanche breakdown of the J2 junction occurs at a lower (but still positive) anode-to-cathode voltage.", "The anode-to-cathode voltage at which the thyristor turns on is therefore dependent upon the gate voltage (gate-to-cathode voltage).", "This positive gate voltage that causes the thyristor to turn on (due to avalanche breakdown of the J2 junction) can be caused by injecting a momentary current pulse 7 into the gate electrode 4.Whether the triggering on is said to occur due to the gate voltage pulse or due to the current of the pulse, the triggering effect of triggering the thyristor on is the same in that avalanche breakdown of the J2 junction is started.", "Once avalanche breakdown of the J2 junction has occurred and the thyristor is on and conducting current from the anode to the cathode, the thyristor remains latched in this on state and the thyristor continues to conduct, irrespective of changes in the gate voltage, until either the anode is no longer forward biased with respect to the cathode, or until the current through the thyristor (anode to cathode) is less than a holding current IH.", "Once the thyristor has been triggered, removing the triggering current does not turn off the thyristor.", "If the anode is positively biased with respect to the cathode, then the thyristor cannot be turned off unless the anode current falls below the holding current IH.", "The thyristor can, however, be switched off if an external circuit momentarily causes the anode to be negatively biased with respect to the cathode.", "Very large and expensive thyristors are used to switch high voltages in high power applications.", "Due to the limited maximum forward voltage drop (anode to cathode) that can be put across a thyristor before it conducts too much current and fails, many thyristors are typically assembled together in series in what is referred to as a stack.", "Each thyristor of the stack therefore only has to handle part of the overall high forward voltage drop across the stack.", "By controlling the gate voltages of the individual thyristors in the stack, the stack can be made to operate as a single high voltage and high power switch that either conducts from one end of the stack to the other, or that does not conduct.", "Thyristor stacks are, for example, used in megawatt scale AC-to-DC and DC-to-AC power conversion, such as for example where the high DC voltage is a voltage on a high voltage DC power transmission line.", "If the magnitude of the high voltage DC were to momentarily pulse high, such as due to the power line being struck by lightning, then an intolerably high transient voltage might be momentarily placed across the thyristor stack (the anode voltage is at too high a positive voltage with respect to the cathode), causing excessive current flow through the stack if the thyristors were on, and causing localized overheating and failure of the stack.", "To avoid this, and to protect the thyristors of the stack from such a transient overvoltage condition, an overvoltage protection device referred to as a BOD (Break Over Diode) device is used.", "BOD devices are coupled to the thyristors of the stack in such a way that the BOD devices turns on the thyristors before excessive over voltage across the thyristors can damage the thyristors.", "The BOD overvoltage protection device detects the high voltage condition and turns on, thereby causing a gate current to flow into the gate of each thyristor, and thereby turning on the thyristor.", "A BOD diode is a thyristor whose gate electrode is not brought out of the device for external connection.", "The BOD diode has an anode electrode and a cathode electrode, but the gate electrode of the device is not brought out.", "The BOD diode is not triggered on by an externally applied pulse of gate current as described above in the case of a conventional thyristor, but rather the BOD diode is triggered on by the onset of avalanche current that is generated within the BOD device itself.", "Operation of the BOD diode is therefore explained using the terminology employed above in connection with the self-latching bipolar transistor structure of FIG.", "3.In a forward blocking mode, as the anode-to-cathode voltage increases to the V(BO)F, the J1 and J3 junctions are forward biased but the J2 junction is reversed biased.", "A depletion region forms at this reverse biased J2 junction, and the resulting separation of charge at the junction gives rise to a localized electric field.", "The strength of the electric field grows to the point that covalent bonds of the material at the J2 junction are broken, and an avalanche current flows, with generated electrons being pulled to the relative positive potential of the anode, and with generated holes being pulled the opposite direction to the relative negative potential of the cathode.", "The hole flow through the P type layer between J2 and J3 results in a voltage drop across the material of the P type layer.", "If the avalanche current is of adequate magnitude, then the voltage drop exceeds 0.7 volts, resulting in the base-to-emitter voltage of the NPN transistor 5 (see FIG.", "3) exceeding 0.7 volts.", "This causes the NPN transistor 5 to turn on.", "The NPN transistor 5 turning on pulls a base current out of the base of the PNP transistor 6.PNP transistor 6 turns on, and supplies current from its collector into the base of the NPN transistor 5.The two transistors are therefore latched on in a self-latching way, with each one supplying a base current to the other.", "Once the BOD diode has triggered itself on in this way, it will remain on unless either the anode is no longer forward biased with respect to the cathode, or until the current through the BOD diode falls below the holding current IH.", "In an overvoltage protection application, the BOD diode is coupled in parallel with a power thyristor of a stack, such that if an excessive forward voltage develops across the power thyristor, then the BOD diode undergoes breakover and turns on, thereby conducting a current.", "This current is supplied as a triggering pulse to the thyristor, so that the thyristor is turned on.", "Accordingly, when the forward voltage across the thyristor reaches an adequately high voltage, the breakover diode supplies a triggering current to the thyristor and causes the thyristor to turn on.", "When the thyristor turns on, the forward voltage drop across the thyristor decreases.", "The thyristor is therefore protected from an over voltage condition.", "FIG.", "4 (Prior Art) is a cross-sectional diagram of a conventional bulk BOD diode 8.The PNPN thyristor structure is evident.", "Whereas the anode electrode 3 of the PNPN structure of FIG.", "2 is illustrated on the top, the anode electrode 9 of the BOD diode of FIG.", "4 is illustrated on the bottom.", "The P type substrate layer 10 is the first P type thyristor layer, the N− type substrate layer 11 is the second N type thyristor layer, the P type base region 12 is the third P type thyristor layer, and the N+ type region 13 is the fourth N type thyristor layer.", "Layers 10 and 11 are both of substrate silicon, so the BOD is referred to here as a “bulk” BOD.", "Reference numeral 14 identifies the cathode electrode.", "The BOD device has guard rings 15 and 16, and a peripheral shallow channel stopper 17.FIG.", "5 (Prior Art) is a diagram that shows the electric field along line A-A′ in FIG.", "4 just before the onset of avalanche breakdown.", "The peak of the electric field is at the J2 PN junction.", "The J2 PN junction is between the N− type base layer 11 and the P type base region 12.When the electric field strength at this point is high enough, then the avalanche current begins to flow.", "If the magnitude of current flow from the junction laterally under the emitter region 13 across the resistance of the P type material of region 12 and to the cathode electrode 14 is adequately high, then the resulting voltage drop will reach 0.7 volts.", "This 0.7 volt drop amounts to a 0.7 base-to-emitter voltage on the NPN transistor, so the thyristor will be triggered on as described above.", "FIG.", "6 (Prior Art) is a diagram that shows the turning on of the BOD device 8 of FIG.", "4.The BOD device has 8 has a reverse breakdown voltage of −200 volts to −300 volts.", "In the forward voltage condition, the solid line 18 in FIG.", "6 represents current flow through the BOD device from anode to cathode.", "The dashed line 19 is the anode-to-cathode voltage across the BOD device.", "As can be seen, the BOD device begins to conduct appreciable current at a forward anode-to-cathode breakover voltage V(BO)F of about +450 volts.", "This is the time when the avalanche current in the BOD device has reached the triggering current.", "Thereafter the current increases and the voltage across the BOD device decreases.", "At time 0.6 microseconds the anode-to-cathode voltage across the BOD device has decreased to zero volts.", "The turn on time (TON) is the time from the time when the internal triggering current is reached at time 0.1 microseconds until the time when the anode-to-cathode voltage reaches zero volts.", "The turn on time (TON) is therefore 0.5 microseconds.", "Because a high transient overvoltage condition can cause a power thyristor of a stack to be destroyed in a short amount of time, a fast turn on BOD is desired for its thyristor-protection function.", "SUMMARY In a first novel aspect, an ultra-fast breakover diode has a turn on time TON of less than 0.3 microseconds, a breakover voltage greater than +400 volts, and the breakover voltage varies less than one percent per ten degree Celsius change.", "The breakover voltage is also repeatable over changes in semiconductor manufacturing process.", "In one example, an anode metal electrode is disposed on a bottom surface of a P type layer of substrate semiconductor material, and an N type buffer layer of epitaxial semiconductor material is disposed on the P type layer.", "The N type buffer layer has an N type dopant concentration between 1×1015 atoms/cm3 and 1×1016 atoms/cm3.A thin layer of N− type base layer of epitaxial semiconductor material is disposed on the N type buffer layer.", "This thin layer is less than 130 microns thick.", "A P type base region extends from a semiconductor surface down into the thin N− type base layer to a depth D. The P type base region has a peripheral edge at the semiconductor surface, and the peripheral edge has a minimum radius of curvature R that is at least twice the depth D. An N+ type annular emitter region extends down from the semiconductor surface down into the P type base region such that material of the P type base region extends up to the semiconductor surface in the center of the N+ annular region and defines a cathode short region of P type semiconductor material.", "The cathode short region has a width at the semiconductor surface that is less than 0.250 millimeters.", "A cathode metal electrode is disposed over part of the annular N+ type emitter and over the cathode short region at the semiconductor surface.", "A floating metal ring is disposed on the P type base region.", "In a second novel aspect, a high voltage breakover diode has comparable forward breakover and reverse breakdown voltages.", "In one example, an anode metal electrode is disposed on a bottom semiconductor surface of a P type layer of substrate semiconductor material.", "An N− type base layer is disposed on the P type layer, and a P type base region extends from an upper semiconductor surface down into the N-type base layer.", "An N+ type annular emitter region extends down from the upper semiconductor surface into the P type base region.", "P type material of the P type base region extends up to the semiconductor surface in the center of the annular emitter region and defines a cathode short region.", "A P type isolation diffusion region extends from the upper semiconductor surface to the bottom semiconductor surface, and the P type isolation diffusion region surrounds the N− type base layer in the lateral dimension so that the P type isolation diffusion contacts each of four side edges of the die of breakover diode device.", "A cathode metal electrode is disposed over part of the annular N+ type emitter and over the cathode short region at the upper semiconductor surface.", "The breakover diode device has a forward breakover voltage (V(BO)F) that is greater than four hundred volts.", "The breakover diode device is also able to withstand a reverse voltage whose absolute value is in excess of the forward breakover voltage without suffering breakdown.", "In a third novel aspect, a packaged overvoltage protection circuit includes a plurality of identical breakover diode dice, and a plurality of resistors.", "The plurality of breakover diode dice are coupled together in series between a first package terminal and a second package terminal.", "The plurality of resistors are coupled together in a resistor string, such that one resistor is in parallel with each of the plurality of breakover diode dice.", "The plurality of breakover diode dice and the plurality of resistors are enclosed in a package housing from which the first and second package terminals extend.", "Each of the breakover diodes has a reverse breakdown voltage that is greater in absolute magnitude than the forward breakover voltage of the breakover diode, and the forward breakover voltage is at least 400 volts.", "Of importance, the packaged overvoltage protection circuit need contain no expensive separate discrete diode with a high reverse breakdown capability.", "The only semiconductor components of the packaged overvoltage protection circuit are the plurality of breakover diode dice.", "Accordingly, the package housing encloses no semiconductor die that comprises any component other than a breakover diode.", "In one application, the packaged overvoltage protection circuit is usable to supply a triggering current to the gate of a thyristor.", "If the voltage between the anode and the cathode of the thyristor exceeds a first positive voltage, then the breakover diodes in the packaged overvoltage protection circuit will undergo breakover such that a triggering current is supplied from the packaged overvoltage protection circuit and into the gate of the thyristor.", "The triggering current turns the thyristor on, and the thyristor conducts a large current to reduce the voltage across the thyristor between the anode and cathode to be less than the first positive voltage.", "A large negative voltage between the gate of the thyristor and the anode of the thyristor will not damage the packaged overvoltage protection circuit because the packaged overvoltage protection circuit can withstand a reverse voltage of a second voltage.", "The second voltage is a large negative voltage that has an absolute value that is greater than the first positive voltage.", "The number of breakover diode dice in series can be increased to increase the first and second voltages.", "In one example, the first voltage is +8000 volts, and the second voltage is −10,000 volts.", "In one example, a snubber circuit is provided between the gate and cathode of the thyristor to soften ill effects of switching voltage spikes on the packaged overvoltage protection circuit.", "A current limiting resistor is placed in series with the packaged overvoltage protection circuit between the thyristor anode and the thyristor gate to limit the magnitude of the triggering current.", "A second identical circuit (packaged overvoltage protection circuit, thyristor, current limiting resistor, and snubber circuit) is provided in parallel with the first circuit to protect against large negative voltages that are more negative than −8000 volts.", "Further details and embodiments and techniques are described in the detailed description below.", "This summary does not purport to define the invention.", "The invention is defined by the claims.", "BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, where like numerals indicate like components, illustrate embodiments of the invention.", "FIG.", "1 (Prior Art) is a diagram of a thyristor symbol.", "FIG.", "2 (Prior Art) is a simplified diagram of the structure of a thyristor.", "FIG.", "3 (Prior Art) is a simplified circuit diagram of a thyristor.", "FIG.", "4 (Prior Art) is a cross-sectional diagram of a bulk breakover diode device.", "FIG.", "5 (Prior Art) is a diagram that illustrates the electric field along sectional line A-A′ in FIG.", "4.FIG.", "6 (Prior Art) is a waveform diagram that shows the turn on time TON of the bulk BOD device of FIG.", "4.FIG.", "7 is a simplified cross-sectional diagram of a breakover diode (BOD) die in accordance with a first novel aspect.", "FIG.", "8 is a diagram of a package that contains the BOD die of FIG.", "7.FIG.", "9 is a schematic diagram of the package of FIG.", "8.FIG.", "10 is a top-down diagram of the BOD die of FIG.", "7.FIG.", "11 is a view of the bottom of the BOD die of FIG.", "7.FIG.", "12 is a circuit diagram of a test circuits used to exercise the BOD die of FIG.", "7.FIG.", "13 is a waveform diagram that shows the turn on time TON of the BOD die of FIG.", "7.FIG.", "14 is a diagram that illustrates the electric field along sectional line B-B′ in FIG.", "7.FIG.", "15 is a diagram that illustrates a depletion region in the BOD die of FIG.", "7 just before avalanche breakdown.", "FIG.", "16 is a diagram that shows BOD devices having different turn on times being manufactured as parts of the same wafer.", "FIG.", "17 is a diagram showing how the forward breakover voltage of the BOD die of FIG.", "7 varies less than one percent per ten degree Celsius change in temperature.", "FIG.", "18 is a diagram showing the V-I characteristic of the BOD die of FIG.", "7.FIG.", "19 is a diagram of a thyristor protection circuit that involves the BOD die of FIG.", "7.FIG.", "20 is a table that sets forth aspects of the composition of various parts of the BOD die of FIG.", "7.FIG.", "21 is a table that shows how the turn on time of a device of the architecture of the BOD die of FIG.", "7 can be adjusted.", "FIG.", "22 is a cross-sectional diagram of a BOD device in accordance with a second novel aspect.", "FIG.", "23 is a diagram of a package that contains the breakover diode device of FIG.", "22.FIG.", "24 is a schematic diagram of the package of FIG.", "23.FIG.", "25 is a top-down diagram of the BOD device of FIG.", "22.FIG.", "26 is a diagram of the bottom of the BOD device of FIG.", "22.FIG.", "27 is a cross-sectional diagram of the BOD device of FIG.", "22 showing the J1 depletion region for a reverse voltage of about −300 volts.", "FIG.", "28 is cross-sectional diagram of the BOD device of FIG.", "22 showing the J1 depletion region for a reverse voltage of about −500 volts.", "FIG.", "29 is a diagram that shows the turn on time TON of the BOD device of FIG.", "22, when the BOD device is tested in the test circuit of FIG.", "12.FIG.", "30 is a diagram that shows the V-I characteristic of the BOD device of FIG.", "22.FIG.", "31 is a table that sets forth aspects of the composition of various parts of the BOD device of FIG.", "22.FIG.", "32 is a diagram of a packaged overvoltage protection circuit in accordance with a third novel aspect.", "FIG.", "33 is a circuit diagram of the packaged overvoltage protection circuit of FIG.", "32 in use with a thyristor, a current limiting resistor, and a snubber.", "DETAILED DESCRIPTION Reference will now be made in detail to background examples and some embodiments of the invention, examples of which are illustrated in the accompanying drawings.", "In the description and claims below, when a first object is referred to as being disposed “over” or “on” a second object, it is to be understood that the first object can be directly on the second object, or an intervening object may be present between the first and second objects.", "Similarly, terms such as “upper”, “top”, “up”, “down”, and “bottom” are used herein to describe relative orientations between different parts of the structure being described, and it is to be understood that the overall structure being described can actually be oriented in any way in three-dimensional space.", "The notations N+, N−, N, P+, and P are only relative, and are to be considered in context, and do not denote any particular dopant concentration range.", "FIG.", "7 is a cross-sectional diagram of a breakover diode (BOD) device 20 in accordance with one novel aspect.", "A metal anode electrode 21 is disposed on the bottom surface of a layer of P type substrate semiconductor material 22.An N type buffer layer 23 of epitaxial semiconductor material is disposed on the P type substrate layer 22.The epitaxial layer is grown on the substrate using known processes.", "An N− type base layer 24 of epitaxial semiconductor material is disposed on the N type buffer layer 23.The N-type base layer 24 is more lightly doped with N type dopants than is the N type buffer layer 23.The N− type layer 24 extends up to an upper semiconductor surface 25 of the die structure.", "The bottom semiconductor surface 26 of the die structure is identified by reference numeral 26.In the illustrated example, the two surfaces 25 and 26 are substantially planar.", "A P type base region 27 extends down into the N− type base layer 24 from the upper semiconductor surface 25.An N+ type annular emitter region 28 extends down into the P type base region 27 from the upper semiconductor surface 25 as shown.", "The region 28 is annular in that it has a ring-shape when considered from the top-down perspective.", "An amount of the P type material of the P type base region 27 extends up in the center of this annular structure so that the P type material reaches the upper semiconductor surface 25.This amount of P type material is referred to as the “cathode short region” 29.Cathode short region 29 has a width W at the upper semiconductor surface 25.A metal cathode electrode 30 is disposed on the upper semiconductor surface 25 so that it makes contact with the N+ type annular emitter region 28 and with the cathode short region 29 at the upper semiconductor surface 25 as shown.", "A floating metal ring 31 is disposed on the upper surface of the P type base region 27 so that the floating metal ring 31 surrounds, but does not touch, the metal cathode electrode 30.The floating metal ring 31 is “floating” in the sense that it is not electrically coupled to the cathode metal electrode 30.The floating metal ring 31 does not extend over any portion of the N− type base layer at the surface 25, nor does it extend over any portion of the annular N+ type emitter region 28 at the surface 25.The floating metal ring 31 is only in contact with the P type base region 27.In addition, the BOD device 20 includes two concentric P+ type guard rings 32 and 33.P+ type guard ring 32 surrounds the P type base region 27, and P+ type guard ring 33 surrounds the P+ type guard ring 32.In addition, the BOD device 20 includes an N+ type channel stopper ring 34.FIG.", "8 is a side view of a packaged BOD device 40.A BOD die of the type illustrated in FIG.", "7 is enclosed in the plastic housing portion 41 the package of FIG.", "40.The anode metal electrode 21 of the die is coupled to metal package terminal PT2 42.The cathode metal electrode 30 of the die is coupled to metal package terminal PT1 43.FIG.", "9 is a schematic diagram of the packaged BOD device 40 of FIG.", "8.The connections 44 and 45 are internal to the package.", "FIG.", "10 is a diagram of the top surface of BOD die 20.The cathode metal electrode 30 has a square shape when viewed from the top-down perspective, except that the corners of the square are rounded.", "The peripheral edge of the P type base region 27 (when viewed from the top-down perspective) has a minimum radius of curvature of radius R. Similarly, the minimum radius of curvature R′ of the floating metal ring 31 is approximately R. From the top-down perspective, the strip-like shape of the floating metal ring 31 follows along the peripheral boundary of the P type base region 27.FIG.", "11 is a diagram of the bottom surface of BOD die 20.Substantially the entire bottom surface of the BOD die is covered in metal of the anode metal electrode 21.FIG.", "12 is a schematic diagram of a test circuit.", "The high voltage DC supply 46 is isolated from the BOD device 20 by 5k ohm resistor 47, capacitor 48, and inductor 49.The values are capacitor 48 and inductor 49 are selected depending on the pulse width and peak current desired.", "A 1800V antiparallel diode 50 is disposed in parallel with BOD device 20 in order to protect the BOD device 20 from any large negative transient voltages that might occur as a consequence of the switching.", "If a negative transient voltage where to develop across the BOD device 20, then diode 50 would conduct and limit the magnitude of this negative voltage across the BOD device.", "A Pearson transformer 51 is provided to detect and measure current 52 that might be flowing.", "In operation, the switch 53 is closed so that the DC voltage charges the capacitor 48 through the resistor 47.The voltage on capacitor 48 increases until the V(BO)F of the BOD device 20 is reached.", "The BOD device 20 is then triggered on, and current 52 begins to flow.", "This current 52 is measured via the Pearson transformer 51.Due to the current flow 52, the capacitor 48 is discharged through the inductance of inductor 49.FIG.", "13 is a waveform diagram showing the voltage across the BOD device 20 and the current flow 52 through the BOD device 20.The BOD device 20 of FIG.", "7 has a reverse breakdown voltage of −20 volts.", "The dashed line 54 in FIG.", "13 represents the voltage across the BOD device 20.Solid line 55 shows the current 52 flowing through the BOD device 20.The voltage across the BOD device 20 increases until the avalanche current reaches the internal triggering current of the BOD device 20, at which time the voltage across the BOD device 20 is V(BO)F at time 0.2 microseconds.", "The BOD device 20 then undergoes breakover, and current flow through the BOD device 20 rises quickly.", "Accordingly, the voltage across the BOD device 20 decreases quickly.", "The voltage across the BOD device 20 reaches zero volts by time 0.5 microseconds.", "The turn on time TON is the time from the time when the avalanche current reaches the triggering current until the time when the voltage across the BOD device has decreased to zero volts.", "The turn on time TON is therefore 0.3 microseconds.", "The subsequent part of the voltage and current waveforms involve ringing and transients that are not important for the considerations here.", "As compared to the 0.5 microsecond turn on time TON of the prior art BOD device of FIG.", "4, the 0.3 microsecond turn on time TON of the BOD device of FIG.", "7 is considerably smaller.", "In one advantageous aspect, the BOD device 20 of FIG.", "7 has a reduced turn on time TON.", "This is accomplished by recognizing that the delay in turn on in the prior art structure of FIG.", "4 is mainly due to slow diffusion of charge carriers through the neutral part of the N− type layer 11.When avalanche occurs at the PN junction between P base region 12 and N− type layer 11, time is required for the charge carriers to pass through the structure and to reach the electrodes.", "In the novel BOD device 20 of FIG.", "7, the thickness of the N-base layer 24 is reduced to be less than 130 microns, as compared to the thicker N− type layer 11 of the prior art structure of FIG.", "4.This reduces the distance the charge carriers have to traverse in a turn on event.", "The forward blocking voltage of the BOD device, however, is limited by the onset of punch-through.", "If, under a reverse bias situation, the depletion region at the PN junction between the P type base 12 and the N− type material of layer 11 were to expand so far that it were to reach the top of the P type layer 10, then punch through would occur.", "At this point the device would breakdown.", "Accordingly, in the conventional design of FIG.", "4 the N-type layer 11 is made thick enough so that under the high voltage forward voltages that the BOD device is to be able to withstand, the depletion region does not reach the P type layer 10.In the novel device of FIG.", "7, on the other hand, the N− type layer 24 is made thinner and punch through is prevented by providing an extra more heavily doped N type buffer layer 23.Due to the low doping concentration in the N− type layer 24, the depletion region grows relative quickly through this layer as the forward voltage across the BOD device increases, but when the depletion region reaches the more highly doped N type buffer layer 23 the depletion region expands downward much more slowly with further increases in the forward voltage.", "The doping concentration of the N type buffer layer 23 is chosen to be high enough that the depletion layer is effectively stopped and does not penetrate deeper than ten microns in the N type buffer layer 23 at the time the breakover voltage is reached.", "This defines the lower limit for the N type dopant concentration in the buffer layer to be approximately 1×1015 atoms/cm3.On the other hand, too high an N type dopant concentration in the buffer layer would reduce the injection efficiency of the P type emitter of the PNP transistor.", "The P type substrate layer 22 is the emitter of this PNP transistor.", "If the injection efficiency of the emitter of the PNP transistor is reduced, then the turn on speed will be reduced.", "This defines the upper limit for the N type dopant concentration in the N type buffer layer 23 to be approximately 1×1017 atoms/cm3.The preferred range for N type dopants in the N type buffer layer 23 is 1×1015 atoms/cm3 to 1×1016 atoms/cm3.The thickness of the N type buffer layer 23 should be as small as possible, while still preventing the depletion region from penetrating through the N type buffer layer.", "This results in a thickness of the N type buffer layer 23 of approximately 15 microns to 25 microns.", "FIG.", "14 is a diagram that shows the strength of the electric field along sectional line B-B′ in the structure of FIG.", "7.The highest electric field strength is at the PN junction between the P type base region 27 and the N− type base layer 24.From this high electric field strength, the electric field decreases at a relatively lower rate (as compared to the rate of decrease of the electric field in FIG.", "5) through the lightly doped N− type base layer 24.The depletion layer extends all the way through the N− type base layer 24, and into the more highly doped N type buffer layer 23.Accordingly, the magnitude of the electric field decreases at a relatively higher rate into the N− type buffer layer 24.The depletion region ends about half way into the N type buffer layer 23, well before the P type substrate is reached.", "FIG.", "15 is a cross-sectional diagram that shows the contour of the outer extent of the depletion region.", "In the diagram, as the forward voltage across the BOD device increases, the depletion region expands from the JN junction (the PN junction between P type region 17 and N-base layer 24) downward and to the right.", "Dashed line 56 indicates the outer extent of the depletion region at a point in time before avalanche breakdown occurs.", "Dashed line 57 indicates the outer extent of the depletion region at a later point in time when there is a greater forward voltage across the BOD device.", "The depletion region has extended into the upper part of the N type buffer layer 23.The P+ type guard rings affect and shape the contour of the boundary of the depletion region so that it has a relatively smooth shape when considered in three-dimensional space.", "The N+ type channel stopper ring 34 stops the depletion region from extending laterally out to the side walls of the die.", "The maximum possible electric field occurs at the PN junction, at the point of highest curvature in the junction.", "This region is indicated in FIG.", "15 by reference numeral 58.In the case of the BOD device 20 that has a very short turn on time TON of 0.3 microseconds, the triggering on of the device due to avalanche breakdown has to occur quickly, and there is not adequate time for the current conducting area of breakdown to spread over the whole emitter area.", "Current flow is restricted to a small area around the point where avalanche breakdown was triggered.", "In a conventional design, such triggering would occur at four points in the bottom corners of the P type base region.", "The P type base region conventionally has corners when considered from the top-down perspective, and the bottom corners are the corner PN junction at the bottom of the P type base region in these four corner areas.", "In accordance with one novel aspect, the turn on time TON of the BOD device 20 is small in part due to increasing the minimum radius of curvature R (see FIG.", "10) of the P type base region.", "The minimum radius of curvature R is the radius of curvature illustrated in FIG.", "10.In one example, the minimum radius of curvature R is at least twice the depth D 59 of the N− type base layer 24, and is preferably four times the depth D of the N− type base layer 24.The region 58 where avalanche is triggered is therefore closer to a ring than it is to four separate points as in the prior art.", "Floating metal ring 31 also facilitates uniform triggering of avalanche breakdown.", "Empirically it has been found that providing the floating metal ring 31 reduces TON.", "Floating metal ring 31 is thought to assist in the making the onset of avalanche more uniform due to equalizing of what might otherwise be local peaks in the electric field in the semiconductor material below the ring.", "In addition to facilitating fast turn on by reducing carrier lifetime in the N-type base layer, and in addition to facilitating fast turn on by promoting uniform and distributed avalanche triggering, fast turn on is further facilitated by reducing the amount of avalanche current that causes the NPN transistor to turn on.", "If charge carriers are generated in region 58 in FIG.", "15, then holes will move from this region laterally to the left through the P type base region 27, passing under the N+ annular emitter region 28, and to the cathode short region 29, and up to the cathode metal electrode 30.Reducing the width of the cathode short region 29, which may result in an increase in the resistance of the current path at this point, is seen to reduce the triggering current required to achieve the requisite 0.7 volt drop to turn on the NPN transistor.", "In one example, the width of the cathode short region is 0.125 millimeters, and the amount of avalanche current required to achieve turn on (the triggering current) is about 10 milliamperes, and the turn on time is 0.3 microseconds or less.", "FIG.", "16 is a diagram of a wafer 60 of BOD devices being manufactured, where different ones of the BOD devices are fabricated to have different triggering currents due to the BOD devices having different cathode short region widths.", "The BOD devices at this point in the semiconductor manufacturing process before wafer dicing are oriented in row and columns on the wafer.", "The upper part 61 of the diagram of FIG.", "16 is a blowup cross-sectional view of a first BOD device 62.The lower part 63 of the diagram of FIG.", "16 is a blowup cross-sectional view of a second BOD device 64.The width W1 of the cathode short region of BOD device 62 is wider than is the width W2 of the cathode short region of BOD device 64.In this way, a single wafer can yield BOD devices having a range of triggering currents.", "In addition to the novel BOD device 20 of FIG.", "7 having a small turn on time, and a small triggering current, the design of the BOD device 20 also results in reduced variability of the forward breakover voltage over temperature, and over process.", "Conventionally, variation in the forward breakover voltages of BOD devices (that ideally should have the same breakover voltage) over temperature is two percent per ten degrees Celsius, or more.", "Moreover, one BOD device manufactured using a design and process may have a forward breakover voltage that varies considerably from the forward breakover voltage of another BOD device manufactured on the same wafer using the same design and process.", "This variation in the forward breakover voltage is undesirable.", "FIG.", "17 is a simplified diagram that illustrates BOD forward breakover voltage versus temperature.", "Line 65 shows how the forward breakover voltage of the prior art BOD diode of FIG.", "4 changes at about two percent per ten degree Celsius change in temperature.", "Line 66 shows how the forward breakover voltage of the novel BOD diode 20 of FIG.", "7 changes with temperature.", "Advantageously, the forward breakover voltage changes less than one percent per ten degree Celsius change in temperature.", "In a conventional BOD device where the N− type layer 11 is thick, and where the depletion region expands downward a greater distance, the shape of the bottom extent of the depletion region is not perfectly planar.", "Variations in the doping concentration of the N− type layer 11 affect the breakover voltage, and variations of ten percent in dopant concentrations is typical.", "In the novel BOD device 20 of FIG.", "7, on the other hand, the entire N− type layer 24 typically depletes prior to breakover.", "The bottom surface of N-type layer 24 is quite planar.", "Further expansion of the depletion region extends into the top of the N type buffer layer 23, but this buffer layer has a much higher N type dopant concentration so the depletion region does not extend far into the buffer layer.", "The bottom extent of the depletion region is therefore quite planar and uniform.", "As compared to difficulties in controlling the N type dopant concentration in the N type layer 11 of the prior art structure, it is easier to control the thickness of the N− type base layer 24 in the BOD device of FIG.", "7.Due to the improved uniformity and repeatability in the way the depletion region grows in devices made using the structure of FIG.", "7, the forward breakover voltages of devices made using the structure of FIG.", "7 are more uniform and repeatable.", "The forward breakover voltage of a particular BOD device is less affected by changes in temperature as shown in the diagram of FIG.", "17.FIG.", "18 is a diagram that shows the V-I characteristic of the BOD device 20 of FIG.", "17.In a simplified explanation, as the forward voltage (the voltage from terminal T2 to terminal T1) increases, the current remains very close to zero and the BOD device is in the forward blocking mode.", "At some high forward voltage, avalanche breakdown begins to occur, but the current flow is not equal to the triggering current.", "When the voltage reaches the forward breakover voltage V(BO)F, then the avalanche current reaches the triggering current, and then breakover occurs and the BOD device turns on.", "The voltage across the BOD device therefore quickly falls to a low voltage VH.", "Once the BOD device is on, an increase in the voltage across the BOD device results in a rapid increase in current.", "The BOD device is effectively a short.", "The BOD device will remain in this forward conductive mode unless the current flow through the BOD device falls below the holding current IH.", "The BOD device is not able to tolerate reverse voltages well, so there is no voltage to current relationship shown for negative voltages.", "FIG.", "19 is a diagram of an overvoltage protection circuit.", "Two such circuits may be provided in antiparallel fashion as a crowbar to protect a piece of equipment (not shown) from voltages more positive than +2000V and from voltages more negative than −2000V.", "With respect to the +2000V protection circuit, if the positive voltage between node 67 and node 68 grows adequately large, then the large positive voltage will effectively be present across packaged BOD device 40.When the voltage reaches the forward breakover voltage of the BOD device, the BOD device breaks over and turns on.", "The resulting current, which is limited by resistor 70, then flows from node 67, through the resistor 70, through a reverse diode 71, through the packaged BOD device 40, and into the gate terminal G of the thyristor 69.This gate current triggers the thyristor 69 on.", "As a result of the triggering current flowing into the gate of thyristor 69, thyristor 69 turns on and conducts a large amount of current from node 67 to node 68, thereby reducing the voltage between nodes 67 and 68, and thereby protecting the equipment from overvoltage.", "The BOD device cannot tolerate large negative voltages (for example, cannot tolerate a negative voltage greater than −20V), so the reverse diode 71 is provided to block current from flowing upward through the BOD device from terminal PT1 to PT2 during large negative voltage situations.", "In addition, the thyristor can turn off rapidly.", "When the thyristor turns off it can generate voltage spikes (voltage spikes between the thyristor cathode and the thyristor gate).", "The RC circuit of resistor 72 and capacitor 73 is a snubber circuit.", "The snubber circuit is provided to soften the effect of the self-induced voltage spikes, and prevents these self-induced spikes from reaching and damaging the BOD device.", "As just described, the circuit pictured in FIG.", "19 protects the equipment against positive voltages in excess of +2000V.", "There is also a similar circuit (not shown) provided in the opposite direction between the same two nodes 67 and 68 to protect the equipment from voltages that are more negative than −2000V.", "The variation in the forward breakover voltage as a function of temperature changes is a major problem because margin needs to be provided in the capability of the other parts of the circuit (such as the thyristor), and in the equipment being protected, to account for the changes in the breakover voltage of the BOD device.", "When temperature increases, the equipment and thyristor still need to be able to tolerate the higher voltage that may be present (due to the breakover voltage of the BOD device increasing).", "The less than one percent change in forward breakover voltage per ten degrees Celsius (see line 66 of FIG.", "17) can result in major cost savings in the overall system as compared to the two percent change in forward breakover voltage per ten degrees Celsius of the prior art bulk BOD of FIG.", "4.FIG.", "20 is a table that shows various aspects of the composition of the BOD device of FIG.", "7.FIG.", "21 is a table that shows how reducing the cathode short region width results in reduced triggering currents.", "FIG.", "22 is a cross-sectional diagram of a BOD device 100 having comparable forward breakover and reverse breakdown voltages in accordance with one novel aspect.", "BOD device 100 has a forward breakover voltage of +450 volts and a reverse breakdown voltage of −500 volts.", "The voltages are comparable in the sense that the absolute magnitude of the reverse breakdown voltage is slightly greater than the forward breakover voltage.", "A metal anode electrode 101 is disposed on the bottom surface of a layer of P type substrate semiconductor material 102.An N− type base layer 103 of substrate semiconductor material is disposed on the P type substrate layer 102.The N− type base layer can be formed by diffusing N type dopants down into the P type substrate material from the upper semiconductor surface.", "The N− type base layer 103 extends up to an upper semiconductor surface 104 of the die structure.", "The bottom semiconductor surface of the die structure is identified by reference numeral 105.In the illustrated example, the two surfaces 104 and 105 are substantially planar.", "A P type base region 106 extends down into the N− type base layer 103 from the upper semiconductor surface 104.An N+ type annular emitter region 107 extends down into the P type base region 106 from the upper semiconductor surface 104 as shown.", "Region 107 is annular in that it has a ring-shape when considered from the top-down perspective.", "An amount of the P type material of the P type base region 106 in the center of the ring extends up so that the P type material reaches the upper semiconductor surface 104.This amount of P type material is referred to as the cathode short region 108.A metal cathode electrode 109 is disposed on the upper semiconductor surface 104 so that it makes contact with the N+ type annular emitter region 107 and with the cathode short region 108 at the upper semiconductor surface 104 as shown.", "An optional floating metal ring 110 is disposed on the upper surface of the P type base region 106 so that the floating metal ring 110 surrounds, but does not touch, the metal cathode electrode 109.This structure of the upper portion of the BOD of FIG.", "22 is similar to the structure of the upper portion of the BOD of FIG.", "7, except that in the case of the BOD of FIG.", "22 a peripheral P type isolation diffusion region 111 is provided.", "The peripheral P type isolation diffusion region 111 extends from the upper semiconductor surface 104 all the way through the die structure to the bottom semiconductor surface 105.The peripheral P type isolation diffusion region reaches the side edges of the die as shown.", "The peripheral P type isolation diffusion region is formed by implanting and diffusing P type dopants into the structure from the upper semiconductor surface 104, and by implanting and diffusing P type dopants into the structure from the bottom semiconductor surface 105, so that the two doped regions meet.", "As in the case of the BOD of FIG.", "7, two P+ type guard rings 112 and 113 are provided and an N+ type channel stopper 114 is provided as well.", "FIG.", "23 is a side view of a packaged BOD device 115.A BOD die of the type illustrated in FIG.", "22 is enclosed in the plastic housing portion 116 of the package of FIG.", "23.The anode metal electrode 101 of the BOD die is coupled to metal package terminal PT2 117.The cathode metal electrode 109 of the BOD die is coupled to metal package terminal PT1 118.FIG.", "24 is a schematic diagram of the packaged BOD device 115 of FIG.", "23.The connections 119 and 120 are internal to the package.", "The BOD device is a N-P-N-P layered device, where the top N type layer is the N+ type annular emitter region, where the next P type layer is the P type base region 106, where the next N type layer is the N− type base layer 103, and where the last P type layer is the P type substrate layer 102.The BOD die 100 does not actually include a reverse diode separate from the BOD diode, but rather the symbols of FIG.", "24 indicate a functionality of the device.", "The reverse diode function is performed by the PN junction of the J1 junction between P type substrate 102 and N− type base layer 103.FIG.", "25 is a top-down diagram of the BOD die 100 of FIG.", "22.As in the case of the BOD die of FIG.", "10 described above, the periphery of P type base region 106 (when considered from the top-down perspective) has a minimum radius of curvature R, where R is at least twice the depth D of the N− type base layer 103, and is preferably four times the depth D of the N− type base layer 103.FIG.", "26 is a diagram of the bottom surface of the BOD die 100 of FIG.", "22.Substantially the entire bottom surface of the BOD die is covered in metal of the metal anode electrode 101.FIG.", "27 is a cross-sectional diagram of the BOD device 100 under a reverse voltage of −300 volts (the anode is −300 volts with respect to the cathode).", "The BOD device 100 successfully blocks this −300 volt reverse voltage.", "The depletion region extends from the J1 PN junction into the N-base layer 103.The depletion region also extends from the J1 PN junction into the P type substrate layer 102 and into the P type isolation diffusion region 111.Whereas the reverse breakdown voltage of the BOD device of FIG.", "19 is about −200 volts, the reverse breakdown voltage of the BOD device of FIG.", "22 is about −500 volts.", "The absolute magnitude of the reverse breakdown voltage (−500 volts) is higher than the forward breakover voltage (+450 volts) because in the forward bias direction the base region 106 has a cylindrical junction.", "In the forward bias direction, without the guard rings, the device would break down at about +100 volts.", "By adding the guard rings the breakdown voltage (−450 volts) in the forward bias direction is increased to about 85% of the breakdown voltage of the bulk silicon.", "In the reverse direction, there is no cylindrical junction.", "The absolute magnitude of the reverse breakdown voltage of the BOD device (−500 volts) is approximately the same as the bulk breakdown voltage of bulk silicon.", "Without the P type isolation region, the reverse breakdown voltage would be approximately −50 volts to −100 volts.", "FIG.", "28 is a cross-sectional diagram of the BOD device 100 under a reverse voltage of −450 volts.", "The BOD device 100 successfully blocks the −450 volt reverse voltage.", "The depletion region extends from the J1 PN junction farther into the N-base layer 103 and farther into the P type substrate layer 102 and the P type isolation diffusion region 111.FIG.", "29 is a waveform diagram showing the voltage across packaged BOD device 115 of FIG.", "23 when the BOD device is put into the test circuit of FIG.", "12.The BOD device 115 of FIG.", "23 has a reverse breakdown voltage of about −500 volts.", "The dashed line 121 in FIG.", "29 shows the voltage across the BOD device in a test.", "Solid line 122 shows the current flowing through the BOD device.", "Avalanche current increases, until the magnitude of the avalanche current reaches the triggering current at the +450 volt forward breakover voltage V(BO)F .", "The forward breakover voltage V(BO)F is reached at 0.1 microseconds.", "The breakover diode then breaks over, and begins to conduct current.", "The voltage across the BOD device drops, and the current increases.", "The voltage across the BOD device reaches zero at time 0.55 microseconds.", "The turn on time TON is the time from when the avalanche current reaches the triggering current until the time when the voltage across the BOD device has decreased to zero.", "The turn on time TON is therefore 0.45 microseconds.", "FIG.", "30 is a diagram that shows the V-I characteristic of the BOD device of FIG.", "22.In a simplified explanation, as the forward voltage (the voltage from terminal T2 to terminal T1) increases, the current remains very close to zero and the BOD device is in the forward blocking mode.", "When the voltage reaches the forward breakover voltage V(BO)F of +450 volts, then breakover occurs and the BOD device turns on.", "The voltage across the BOD device therefore falls quickly to a low voltage VH.", "Once the BOD device is on, an increase in the voltage across the BOD device results in a rapid increase in current.", "The BOD device is effectively a short.", "The BOD device will remain in this forward conductive mode unless the current flow through the BOD device falls below the holding current IH.", "Unlike the BOD device of FIG.", "7, the BOD device of FIG.", "22 is able to tolerate reverse voltages up to −500 volts.", "If the reverse voltage exceeds this −500 volt value, then the BOD device undergoes breakdown and a reverse current flows.", "This is the “reverse avalanche region” labeled on the diagram.", "The reverse breakdown voltage (also sometimes called the “reverse breakover voltage”) of the BOD device is −500 volts, which is slightly larger in absolute magnitude than the +450 volt forward breakover voltage.", "Using the architecture of the BOD device of FIG.", "22, the reverse breakdown voltage is made to be a little larger in absolute magnitude than the forward breakover voltage, and the forward breakover voltage can be made to be anywhere in a range from +200V to greater than +900V.", "FIG.", "31 is a table that shows the composition of the various parts of the BOD device of FIG.", "22.In this example, as indicated in the graph of FIG.", "30, the BOD device 100 of FIG.", "22 has a forward breakover voltage of +450 volts, and a reverse breakdown voltage of −500 volts.", "FIG.", "32 is a side view of a packaged overvoltage protection circuit 123 in accordance with another embodiment.", "The packaged device 123 includes a housing portion 124, a PT2 package terminal 125, and a PT1 package terminal 126.A plurality of BOD dice of the type illustrated in FIG.", "22, along with other components, are enclosed in the housing portion 124.FIG.", "33 is a circuit diagram of an apparatus and circuit 136.Apparatus and circuit 136 involves the packaged device 123 of FIG.", "32 in use in combination with a thyristor 127.The apparatus and circuit 136 includes a current limiting resistor 128, the packaged device 123, and a RC snubber circuit 129, 130.Operation of the circuit of FIG.", "33 is similar to the operation of the circuit of FIG.", "19 described above.", "The packaged overvoltage protection circuit 123 functions similar to a single BOD device that has a forward breakover voltage of +8000 volts, and a reverse breakdown voltage of −10,000 volts.", "The contents of the packaged device 123 is shown encircled in the dashed line 123.Within packaged device 123 there are four identical dice 131-134 of the type of FIG.", "22, with these dice being coupled in series between package terminal PT2 and package terminal PT1.If the forward voltage drop between PT2 and PT1 reaches the forward breakover voltage of +8000 volts, then the BOD devices undergo breakover and a breakover current flows through the BOD devices in current path 135 from PT2 to PT1.But for a small leakage current that flows through the resistor string 136-139, the packaged device 123 blocks substantially all current flow for positive voltages between PT2 and PT1 unless the forward voltage reaches or exceeds +8000 volts.", "The triggering current of the BOD device may, for example, be 10 mA and this current only flows at high forward voltages approaching V(BO)F. In the reverse direction, each of the BOD devices can withstand a reverse voltage of −500 volts before suffering breakdown.", "Accordingly, other than for a small leakage current that flows through the resistor string 136-139 and a small triggering current, the packaged device 123 blocks current flow for negative voltages between PT2 and PT1 unless the negative voltage reaches or exceeds −10,000 volts.", "The resistances of the resistors is made large so that the current flow through the resistor string is inconsequential.", "In operation, if the voltage between node 140 and 141 reaches +8000 volts, then the BOD devices in packaged device 123 undergo breakover, and a current flows from PT2 to PT1 and this current is injected into the gate of thyristor 127, thereby turning on the thyristor.", "As a consequence of the thyristor turning on, the thyristor conducts a large current from node 140 to node 141 through the thyristor, and this large current reduces the voltage between nodes 140 and 141 to a voltage below the +8000 volts.", "Equipment 142 that is not to experience voltages in excess of +8000 volts is connected across the nodes 140 and 141, so that the circuit of FIG.", "33 will prevent the voltage between those nodes from exceeding +8000 volts.", "As explained above in connection with FIG.", "19, resistor 128 has a current limiting function in limiting the magnitude of the triggering current sent into the gate of the thyristor.", "The snubber 129, 130 protects the BOD devices from potentially harmful voltage spikes that the thyristor itself generates between the gate and cathode of the thyristor.", "The thyristor may generate such spikes when it turn on and/or off rapidly.", "Due the ability of each BOD device to block a reverse voltage of −500 volts, the circuit of FIG.", "33 does not include an expensive reverse diode such as reverse diode 71 of FIG.", "19.As explained above in connection with FIG.", "19, there is typically another circuit identical to the circuit of FIG.", "33 where this other circuit is coupled in antiparallel fashion to nodes 140 and 141.The first circuit is to stop positive voltages more positive than +8000 volts from appearing between nodes 140 and 141, whereas the second circuit is to stop negative voltages more negative than −8000 volts from appearing between nodes 140 and 141.Equipment to be protected 142 in this case is not to see voltages whose absolute magnitudes are greater than 8000 volts.", "Although an embodiment is shown in which a resistor is coupled in parallel with each individual BOD device, some BOD devices may not have such a parallel-connected resistor in some embodiments.", "Although an embodiment is shown in which all the BOD devices are identical, in another embodiments BOD devices that have different forward breakover voltages are provided in the same packaged overvoltage protection circuit to provide a desired different overall forward breakover voltage and a desired different overall reverse breakdown voltage of the overall packaged overvoltage protection circuit.", "Although certain specific embodiments are described above for instructional purposes, the teachings of this patent document have general applicability and are not limited to the specific embodiments described above.", "Accordingly, various modifications, adaptations, and combinations of various features of the described embodiments can be practiced without departing from the scope of the invention as set forth in the claims." ] ]
Patent_15876139
[ [ "VIDEO DISTRIBUTION METHOD AND DEVICE", "Embodiments of the present invention relate to the communications field, and provide a video distribution method and a device.", "The method includes: receiving, by an SCEF, a first request message sent by a third-party server, where the first request message includes an MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; sending, by the SCEF, a second request message to an HSS according to the first request message, to request the HSS to expose an MBMS capability; sending, by the SCEF, a third request message to a broadcast multicast service center BM-SC after the SCEF receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request to obtain MBMS capability information exposed by the BM-SC; and sending the MBMS capability information obtained from the BM-SC to the third-party server." ], [ "1.A video distribution method, comprising: receiving, by a service capability exposure function (SCEF), a first request message sent by a third-party server, wherein the first request message comprises a multimedia broadcast multicast service (MBMS) capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; sending, by the SCEF, a second request message to a home subscriber server (HSS) according to the first request message, to request the HSS to expose an MBMS capability; sending, by the SCEF, a third request message to a broadcast multicast service center (BM-SC) after the SCEF receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request first MBMS capability information exposed by the BM-SC; and sending, by the SCEF, the first MBMS capability information obtained from the BM-SC to the third-party server, to enable the-third party server to request, according to the first MBMS capability information, to start an MBMS broadcast, and distributes video content to user equipment (UE).", "2.The method according to claim 1, wherein the first request message further comprises port information of the third-party server and media encoding information of the third-party server; the second request message comprises the MBMS capability negotiation parameter and/or an MBMS media capability exposure request indication, and the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability; if the second request message comprises the MBMS capability negotiation parameter, the second response message comprises second MBMS capability information that is to be exposed and that is determined by the HSS according to subscription information between the HSS and an operator and the MBMS capability negotiation parameter; if the second request message comprises the MBMS media capability exposure request indication, the second response message comprises an MBMS capability exposure request indication, and the MBMS capability exposure request indication is used to request the first MBMS capability information exposed and determined by the BM-SC; the third request message comprises the port information of the third-party server and the media encoding information of the third-party server; and if the second response message comprises the second MBMS capability information, the third request message further comprises the second MBMS capability information; or if the second response message does not comprise the second MBMS capability information, the third request message further comprises the MBMS capability negotiation parameter.", "3.The method according to claim 2, wherein before the sending, by the SCEF, the first MBMS capability information obtained from the BM-SC to the third-party server, the method further comprises: receiving, by the SCEF, a third response message sent by the BM-SC, wherein the third response message comprises the first MBMS capability information, a service portal link for transporting the video content, port information of the BM-SC, a charging rule, and media encoding information of the BM-SC.", "4.The method according to claim 3, wherein the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately comprise at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience (QoE) reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, wherein the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information comprising at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported; the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information comprises at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "5.A service capability exposure function (SCEF), comprising: a receiver, configured to receive a first request message sent by a third-party server, wherein the first request message comprises a multimedia broadcast multicast service (MBMS) capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; and a transmitter, configured to send a second request message to a home subscriber server (HSS) according to the first request message, to request the HSS to expose an MBMS capability, wherein the transmitter is further configured to send a third request message to a broadcast multicast service center (BM-SC) when the receiver receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request first MBMS capability information exposed by the BM-SC; and the transmitter is further configured to send the first MBMS capability information obtained from the BM-SC to the third-party server, to enable the-third party server to request, according to the first MBMS capability information, to start an MBMS broadcast, and distributes video content to user equipment UE.", "6.The SCEF according to claim 5, wherein the first request message further comprises port information of the third-party server and media encoding information of the third-party server; the second request message comprises the MBMS capability negotiation parameter and/or an MBMS media capability exposure request indication, and the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability; if the second request message comprises the MBMS capability negotiation parameter, the second response message comprises second MBMS capability information that is to be exposed and that is determined by the HSS according to subscription information between the HSS and an operator and the MBMS capability negotiation parameter; if the second request message comprises the MBMS media capability exposure request indication, the second response message comprises an MBMS capability exposure request indication, and the MBMS capability exposure request indication is used to request the first MBMS capability information exposed and determined by the BM-SC; the third request message comprises the port information of the third-party server and the media encoding information of the third-party server; and if the second response message comprises the second MBMS capability information, the third request message further comprises the second MBMS capability information; or if the second response message does not comprise the second MBMS capability information, the third request message further comprises the MBMS capability negotiation parameter.", "7.The SCEF according to claim 6, wherein the receiver is further configured to receive a third response message sent by the BM-SC, wherein the third response message comprises the first MBMS capability information, a service portal link for transporting the video content, port information of the BM-SC, a charging rule, and media encoding information of the BM-SC.", "8.The SCEF according to claim 7, wherein the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately comprise at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience (QoE) reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, wherein the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information comprising at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported; and the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information comprises at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "9.A third-party server, comprising: a transmitter, configured to send a first request message to a service capability exposure function (SCEF), wherein the first request message comprises a multimedia broadcast multicast service (MBMS) capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; a receiver, configured to receive a first response message sent by the SCEF, wherein the first response message comprises exposed MBMS capability information obtained by the SCEF and a service portal link that is used for transporting video content and that is obtained from a broadcast multicast service center BM-SC, wherein the transmitter is further configured to send, to UE, the service portal link for transporting the video content; and a processor, configured to request, according to the MBMS capability information, to start an MBMS broadcast to distribute the video content to the UE.", "10.The third-party server according to claim 9, wherein the MBMS capability negotiation parameter and the MBMS capability information separately comprise at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience (QoE) reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, wherein the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information comprising at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported; the first request message further comprises port information of the third-party server and media encoding information of the third-party server; and the first response message further comprises port information of the BM-SC, media encoding information of the BM-SC, and a charging rule that are obtained by the SCEF; and, wherein the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information comprises at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "11.The third-party server according to claim 9, wherein the receiver is further configured to: before the transmitter sends the first request message to the SCEF, or after the receiver receives the first response message sent by the SCEF, receive Hypertext Transfer Protocol (HTTP) request messages sent by at least two UEs, wherein the HTTP request message is used to request same video content.", "12.The third-party server according to claim 9, wherein the transmitter is further configured to: after sending, to the user equipment UE, the service portal link for transporting the video content, send the video content to the BM-SC or the SCEF." ], [ "<SOH> BACKGROUND <EOH>OTT (Over The Top) means that an Internet company develops, by bypassing an operator, various open Internet-based video and data serving services, that is, only a network transmission capability of the operator is used, and a third party other than the operator provides an Internet television service or the like.", "In an existing service and capability exposure (Service Exposure and Enablement Support, SEES) technology, an OTT third party (for example, Sohu video, LeTV, Baidu browser, or Tencent WeChat) may provide, by using a network transmission capability, a 3rd Generation Partnership Project (3GPP) network with a time period for requesting data, a volume of data sent in a specified region, quality of service (QoS), a priority, and the like.", "The 3GPP network sends, according to a request of the OTT third party, specified data according to QoS and a priority of network authorization in a specified region, and provides the OTT third party with a recommended time period, charging policy information, network anomaly information, status information of user equipment (UE), and the like.", "If the operator supports an OTT video, none of multimedia broadcast multicast service (MBMS) supporting capabilities of the 3GPP network that include a media format support capability, a media distribution capability, a caching/transcoding capability, and an advertisement insertion capability are described in an existing 3GPP network capability exposure framework.", "In this way, the operator needs to perform interoperability testing with each OTT third party and develop and customize a video support capability for each OTT third party.", "For the OTT third party, because each operator has a different MBMS capability, if the OTT third party does not use an MBMS video support capability of the 3GPP network, the OTT third party still needs to perform interoperability testing with each operator, to adapt to different operator pipes and video supporting capabilities of different terminals.", "This increases IOT (interoperability testing) workload of the OTT third party, causing heavy video distribution and management load." ], [ "<SOH> SUMMARY <EOH>Embodiments of the present invention provide a video distribution method and a device, so as to resolve problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network.", "According to a first aspect, a video distribution method is provided, including: receiving, by a service capability exposure function SCEF, a first request message sent by a third-party server, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; sending, by the SCEF, a second request message to a home subscriber server HSS according to the first request message, to request the HSS to expose an MBMS capability; sending, by the SCEF, a third request message to a broadcast multicast service center BM-SC after the SCEF receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request first MBMS capability information exposed by the BM-SC; and sending, by the SCEF, the first MBMS capability information obtained from the BM-SC to the third-party server, to enable the-third party server to request, according to the first MBMS capability information, to start an MBMS broadcast, and distributes video content to user equipment UE.", "With reference to the first aspect, in a first possible implementation of the first aspect, the first request message further includes port information of the third-party server and media encoding information of the third-party server; the second request message includes the MBMS capability negotiation parameter and/or an MBMS media capability exposure request indication, and the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability; if the second request message includes the MBMS capability negotiation parameter, the second response message includes second MBMS capability information that is to be exposed and that is determined by the HSS according to subscription information between the HSS and an operator and the MBMS capability negotiation parameter; or if the second request message includes the MBMS media capability exposure request indication, the second response message includes an MBMS capability exposure request indication, and the MBMS capability exposure request indication is used to request the first MBMS capability information exposed and determined by the BM-SC; the third request message includes the port information of the third-party server and the media encoding information of the third-party server; and if the second response message includes the second MBMS capability information, the third request message further includes the second MBMS capability information; or if the second response message does not include the second MBMS capability information, the third request message further includes the MBMS capability negotiation parameter.", "With reference to the first possible implementation of the first aspect, in a second possible implementation of the first aspect, before the sending, by the SCEF, the first MBMS capability information obtained from the BM-SC to the third-party server, the method further includes: receiving, by the SCEF, a third response message sent by the BM-SC, where the third response message includes the first MBMS capability information, a service portal link for transporting the video content, port information of the BM-SC, a charging rule, and media encoding information of the BM-SC.", "With reference to the second possible implementation of the first aspect, in a third possible implementation of the first aspect, the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported; and the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "According to a second aspect, a video distribution method is provided, including: sending, by a third-party server, a first request message to a service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; receiving, by the third-party server, a first response message sent by the SCEF, where the first response message includes exposed MBMS capability information obtained by the SCEF and a service portal link that is used for transporting video content and that is obtained from a broadcast multicast service center BM-SC; and sending, by the third-party server to the UE, the service portal link for transporting the video content, and requesting, according to the MBMS capability information, to start an MBMS broadcast to distribute the video content to the UE.", "With reference to the second aspect, in a first possible implementation of the second aspect, the MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported; the first request message further includes port information of the third-party server and media encoding information of the third-party server; and the first response message further includes port information of the BM-SC, media encoding information of the BM-SC, and a charging rule that are obtained by the SCEF; where the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "With reference to the second aspect or the first possible implementation of the second aspect, in a second possible implementation of the second aspect, before the sending, by a third-party server, a first request message to an SCEF, or after the receiving, by the third-party server, a first response message sent by the SCEF, the method further includes: receiving, by the third-party server, Hypertext Transfer Protocol HTTP request messages sent by at least two UEs, where the HTTP request message is used to request same video content.", "With reference to the second aspect or the first possible implementation or the second possible implementation of the second aspect, in a third possible implementation of the second aspect, after the sending, by the third-party server to user equipment UE, the service portal link for transporting the video content, the method further includes: sending, by the third-party server, the video content to the BM-SC or the SCEF.", "According to a third aspect, a video distribution method is provided, including: receiving, by a broadcast multicast service center BM-SC, a first request message sent by a service capability exposure function SCEF, where the first request message is used to obtain multimedia broadcast multicast service MBMS capability information during video content distribution; and sending, by the BM-SC, a first response message to the SCEF, where the first response message includes first MBMS capability information exposed by the BM-SC, so as to distribute video content to user equipment UE after the SCEF starts an MBMS broadcast according to the first MBMS capability information.", "With reference to the third aspect, in a first possible implementation of the third aspect, the first request message includes an MBMS capability negotiation parameter for video distribution and that is requested by a third-party server, or the first request message includes second MBMS capability information that is to be exposed and that is determined by a home subscriber server HSS according to the MBMS capability negotiation parameter obtained from the third-party server; and before the sending, by the BM-SC, a first response message to the SCEF, the method further includes: determining, by the BM-SC according to the MBMS capability negotiation parameter and subscription information between the BM-SC and an operator, the first MBMS capability information exposed by the BM-SC; or determining, by the BM-SC according to the second MBMS capability information that is to be exposed and that is determined by the HSS and subscription information between the BM-SC and the operator, the first MBMS capability information exposed by the BM-SC.", "With reference to the third aspect or the first possible implementation of the third aspect, in a second possible implementation of the third aspect, the first request message further includes port information of the third-party server and media encoding information of the third-party server; and the first response message includes port information of the BM-SC, a service portal link for transporting the video content, a charging rule, and media encoding information of the BM-SC; and the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "With reference to the second possible implementation of the third aspect, in a third possible implementation of the third aspect, the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "With reference to the second possible implementation or the third possible implementation of the third aspect, in a fourth possible implementation of the third aspect, after the sending, by the BM-SC, a first response message to the SCEF, the method further includes: sending, by the BM-SC to the UE, the service portal link for transporting the video content; and receiving, by the BM-SC according to the port information of the BM-SC, video content sent by the third-party server, and sending the video content to the UE.", "According to a fourth aspect, a video distribution method is provided, including: receiving, by a home subscriber server HSS, a first request message sent by a service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution and that is sent by a third-party server AS by using the SCEF, and/or an MBMS media capability exposure request indication sent by the SCEF, where the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability; and determining, by the HSS according to subscription information between the HSS and an operator, and the MBMS capability negotiation parameter and/or the MBMS media capability exposure request, whether to allow the exposure of the MBMS capability.", "With reference to the fourth aspect, in a first possible implementation of the fourth aspect, if the first request message includes the MBMS capability negotiation parameter, when the HSS determines to allow the exposure of the MBMS capability, the method further includes: determining, by the HSS, exposed MBMS capability information according to the subscription information and the MBMS capability negotiation parameter; and sending, by the HSS, a first response message to the SCEF, where the first response message includes the MBMS capability information, where if the first request message includes the MBMS media capability exposure request indication, and the HSS determines to allow the exposure of the MBMS capability, the first response message includes an MBMS capability exposure request indication, to notify the SCEF that the exposure of the MBMS capability is allowed.", "With reference to the first possible implementation of the fourth aspect, in a second possible implementation, the MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "According to a fifth aspect, a service capability exposure function SCEF is provided, including: a receiving unit, configured to receive a first request message sent by a third-party server, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; and a sending unit, configured to send a second request message to a home subscriber server HSS according to the first request message, to request the HSS to expose an MBMS capability, where the sending unit is further configured to send a third request message to a broadcast multicast service center BM-SC when the receiving unit receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request first MBMS capability information exposed by the BM-SC; and the sending unit is further configured to send the first MBMS capability information obtained from the BM-SC to the third-party server, to enable the-third party server to request, according to the first MBMS capability information, to start an MBMS broadcast, and distributes video content to user equipment UE.", "With reference to the fifth aspect, in a first possible implementation of the fifth aspect, the first request message further includes port information of the third-party server and media encoding information of the third-party server; the second request message includes the MBMS capability negotiation parameter and/or an MBMS media capability exposure request indication, and the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability; if the second request message includes the MBMS capability negotiation parameter, the second response message includes second MBMS capability information that is to be exposed and that is determined by the HSS according to subscription information between the HSS and an operator and the MBMS capability negotiation parameter; or if the second request message includes the MBMS media capability exposure request indication, the second response message includes an MBMS capability exposure request indication, and the MBMS capability exposure request indication is used to request the first MBMS capability information exposed and determined by the BM-SC; the third request message includes the port information of the third-party server and the media encoding information of the third-party server; and if the second response message includes the second MBMS capability information, the third request message further includes the second MBMS capability information; or if the second response message does not include the second MBMS capability information, the third request message further includes the MBMS capability negotiation parameter.", "With reference to the first possible implementation of the fifth aspect, in a second possible implementation of the fifth aspect, the receiving unit is further configured to: receive a third response message sent by the BM-SC, where the third response message includes the first MBMS capability information, a service portal link for transporting the video content, port information of the BM-SC, a charging rule, and media encoding information of the BM-SC.", "With reference to the first possible implementation of the fifth aspect, in a second possible implementation of the fifth aspect, the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported; and the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "According to a sixth aspect, a third-party server is provided, including: a sending unit, configured to send a first request message to a service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; a receiving unit, configured to receive a first response message sent by the SCEF, where the first response message includes exposed MBMS capability information obtained by the SCEF and a service portal link that is used for transporting video content and that is obtained from a broadcast multicast service center BM-SC, where the sending unit is further configured to send, to the UE, the service portal link for transporting the video content; and a processing unit, configured to request, according to the MBMS capability information, to start an MBMS broadcast to distribute the video content to the UE.", "With reference to the sixth aspect, in a first possible implementation of the sixth aspect, the MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported; the first request message further includes port information of the third-party server and media encoding information of the third-party server; and the first response message further includes port information of the BM-SC, media encoding information of the BM-SC, and a charging rule that are obtained by the SCEF; where the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "With reference to the sixth aspect or the first possible implementation of the sixth aspect, in a second possible implementation of the sixth aspect, the receiving unit is further configured to: before the third-party server sends the first request message to the SCEF, or after the third-party server receives the first response message sent by the SCEF, receive Hypertext Transfer Protocol HTTP request messages sent by at least two UEs, where the HTTP request message is used to request same video content.", "With reference to the sixth aspect or the first possible implementation or the second possible implementation of the sixth aspect, in a third possible implementation of the sixth aspect, the sending unit is further configured to: after sending, to the user equipment UE, the service portal link for transporting the video content, send the video content to the BM-SC or the SCEF.", "According to a seventh aspect, a broadcast multicast service center BM-SC is provided, including: a receiving unit, configured to receive a first request message sent by a service capability exposure function SCEF, where the first request message is used to obtain multimedia broadcast multicast service MBMS capability information during video content distribution; and a sending unit, configured to send a first response message to the SCEF, where the first response message includes first MBMS capability information exposed by the BM-SC, so as to distribute video content to user equipment UE after the SCEF starts an MBMS broadcast according to the first MBMS capability information.", "With reference to the seventh aspect, in a first possible implementation of the seventh aspect, the first request message includes an MBMS capability negotiation parameter for video distribution and that is requested by a third-party server, or the first request message includes second MBMS capability information that is to be exposed and that is determined by a home subscriber server HSS according to the MBMS capability negotiation parameter obtained from the third-party server; and the BM-SC further includes: a processing unit, configured to determine, according to the MBMS capability negotiation parameter and subscription information between the BM-SC and an operator, the first MBMS capability information exposed by the BM-SC; or the processing unit is configured to determine, according to the second MBMS capability information that is to be exposed and that is determined by the HSS and subscription information between the BM-SC and the operator, the first MBMS capability information exposed by the BM-SC.", "With reference to the seventh aspect or the first possible implementation of the seventh aspect, in a second possible implementation of the seventh aspect, the first request message further includes port information of the third-party server and media encoding information of the third-party server; and the first response message includes port information of the BM-SC, a service portal link for transporting the video content, a charging rule, and media encoding information of the BM-SC; and the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "With reference to the second possible implementation of the seventh aspect, in a third possible implementation of the seventh aspect, the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "With reference to the second possible implementation or the third possible implementation of the seventh aspect, in a fourth possible implementation of the seventh aspect, the sending unit is further configured to: send, to the UE, the service portal link for transporting the video content; the receiving unit is further configured to receive, according to the port information of the BM-SC, video content sent by the third-party server; and the sending unit is further configured to send the video content to the UE.", "According to an eighth aspect, a home subscriber server HSS is provided, including: a receiving unit, configured to receive a first request message sent by a service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution and that is sent by a third-party server AS by using the SCEF, and/or an MBMS media capability exposure request indication sent by the SCEF, where the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability; and a processing unit, configured to determine, according to subscription information between the HSS and an operator, and the MBMS capability negotiation parameter and/or the MBMS media capability exposure request, whether to allow the exposure of the MBMS capability.", "With reference to the eighth aspect, in a first possible implementation of the eighth aspect, if the first request message includes the MBMS capability negotiation parameter, the processing unit is further configured to determine exposed MBMS capability information according to the subscription information and the MBMS capability negotiation parameter; and the HSS further includes a sending unit, configured to send a first response message to the SCEF, where the first response message includes the MBMS capability information, where if the first request message includes the MBMS media capability exposure request indication, and the HSS determines to allow the exposure of the MBMS capability, the first response message includes an MBMS capability exposure request indication, to notify the SCEF that the exposure of the MBMS capability is allowed.", "With reference to the first possible implementation of the eighth aspect, in a second possible implementation of the eighth aspect, the MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "According to a ninth aspect, a service capability exposure function SCEF is provided, including: a receiver, configured to receive a first request message sent by a third-party server, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; and a transmitter, configured to send a second request message to a home subscriber server HSS according to the first request message, to request the HSS to expose an MBMS capability, where the transmitter is further configured to send a third request message to a broadcast multicast service center BM-SC when the receiver receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request first MBMS capability information exposed by the BM-SC; and the transmitter is further configured to send the first MBMS capability information obtained from the BM-SC to the third-party server, to enable the-third party server to request, according to the first MBMS capability information, to start an MBMS broadcast, and distributes video content to user equipment UE.", "With reference to the ninth aspect, in a first possible implementation of the ninth aspect, the first request message further includes port information of the third-party server and media encoding information of the third-party server; the second request message includes the MBMS capability negotiation parameter and/or an MBMS media capability exposure request indication, and the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability; if the second request message includes the MBMS capability negotiation parameter, the second response message includes second MBMS capability information that is to be exposed and that is determined by the HSS according to subscription information between the HSS and an operator and the MBMS capability negotiation parameter; or if the second request message includes the MBMS media capability exposure request indication, the second response message includes an MBMS capability exposure request indication, and the MBMS capability exposure request indication is used to request the first MBMS capability information exposed and determined by the BM-SC; the third request message includes the port information of the third-party server and the media encoding information of the third-party server; and if the second response message includes the second MBMS capability information, the third request message further includes the second MBMS capability information; or if the second response message does not include the second MBMS capability information, the third request message further includes the MBMS capability negotiation parameter.", "With reference to the first possible implementation of the ninth aspect, in a second possible implementation of the ninth aspect, the receiver is further configured to receive a third response message sent by the BM-SC, where the third response message includes the first MBMS capability information, a service portal link for transporting the video content, port information of the BM-SC, a charging rule, and media encoding information of the BM-SC.", "With reference to the second possible implementation of the ninth aspect, in a third possible implementation of the ninth aspect, the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported; and the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "According to a tenth aspect, a third-party server is provided, including: a transmitter, configured to send a first request message to a service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; a receiver, configured to receive a first response message sent by the SCEF, where the first response message includes exposed MBMS capability information obtained by the SCEF and a service portal link that is used for transporting video content and that is obtained from a broadcast multicast service center BM-SC, where the transmitter is further configured to send, to the UE, the service portal link for transporting the video content; and a processor, configured to request, according to the MBMS capability information, to start an MBMS broadcast to distribute the video content to the UE.", "With reference to the tenth aspect, in a first possible implementation of the tenth aspect, the MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported; the first request message further includes port information of the third-party server and media encoding information of the third-party server; and the first response message further includes port information of the BM-SC, media encoding information of the BM-SC, and a charging rule that are obtained by the SCEF; where the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "With reference to the tenth aspect or the first possible implementation of the tenth aspect, in a second possible implementation of the tenth aspect, the receiver is further configured to: before the transmitter sends the first request message to the SCEF, or after the receiver receives the first response message sent by the SCEF, receive Hypertext Transfer Protocol HTTP request messages sent by at least two UEs, where the HTTP request message is used to request same video content.", "With reference to the tenth aspect or the first possible implementation or the second possible implementation of the tenth aspect, in a third possible implementation of the tenth aspect, the transmitter is further configured to: after sending, to the user equipment UE, the service portal link for transporting the video content, send the video content to the BM-SC or the SCEF.", "According to an eleventh aspect, a broadcast multicast service center BM-SC is provided, including: a receiver, configured to receive a first request message sent by a service capability exposure function SCEF, where the first request message is used to obtain multimedia broadcast multicast service MBMS capability information during video content distribution; and a transmitter, configured to send a first response message to the SCEF, where the first response message includes first MBMS capability information exposed by the BM-SC, so as to distribute video content to user equipment UE after the SCEF starts an MBMS broadcast according to the first MBMS capability information.", "With reference to the eleventh aspect, in a first possible implementation of the eleventh aspect, the first request message includes an MBMS capability negotiation parameter for video distribution and that is requested by a third-party server, or the first request message includes second MBMS capability information that is to be exposed and that is determined by a home subscriber server HSS according to the MBMS capability negotiation parameter obtained from the third-party server; and the BM-SC further includes: a processor, configured to: determine, according to the MBMS capability negotiation parameter and subscription information between the BM-SC and an operator, the first MBMS capability information exposed by the BM-SC; or determine, according to the second MBMS capability information that is to be exposed and that is determined by the HSS and subscription information between the BM-SC and the operator, the first MBMS capability information exposed by the BM-SC.", "With reference to the eleventh aspect or the first possible implementation of the eleventh aspect, in a second possible implementation of the eleventh aspect, the first request message further includes port information of the third-party server and media encoding information of the third-party server; and the first response message includes port information of the BM-SC, a service portal link for transporting the video content, a charging rule, and media encoding information of the BM-SC; and the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "With reference to the second possible implementation of the eleventh aspect, in a third possible implementation of the eleventh aspect, the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "With reference to the second possible implementation or the third possible implementation of the eleventh aspect, in a fourth possible implementation of the eleventh aspect, the transmitter is further configured to send, to the UE, the service portal link for transporting the video content; and the receiver is further configured to receive, according to the port information of the BM-SC, video content sent by the third-party server; and the transmitter is further configured to send the video content to the UE.", "According to a twelfth aspect, a home subscriber server HSS is provided, including: a receiver, configured to receive a first request message sent by a service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution and that is sent by a third-party server AS by using the SCEF, and/or an MBMS media capability exposure request indication sent by the SCEF, where the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability; and a processor, configured to determine, according to subscription information between the HSS and an operator, and the MBMS capability negotiation parameter and/or the MBMS media capability exposure request, whether to allow the exposure of the MBMS capability.", "With reference to the twelfth aspect, in a first possible implementation of the twelfth aspect, if the first request message includes the MBMS capability negotiation parameter, when the processor is configured to determine to allow the exposure of the MBMS capability, the processor is further configured to determine exposed MBMS capability information according to the subscription information and the MBMS capability negotiation parameter; and the transmitter is further configured to send a first response message to the SCEF, where the first response message includes the MBMS capability information, where if the first request message includes the MBMS media capability exposure request indication, and the HSS determines to allow the exposure of the MBMS capability, the first response message includes an MBMS capability exposure request indication, to notify the SCEF that the exposure of the MBMS capability is allowed.", "With reference to the first possible implementation of the twelfth aspect, in a second possible implementation of the twelfth aspect, the MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "The embodiments of the present invention provide a video distribution method and a device.", "The SCEF receives a first request message sent by the third-party server, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server, and sends a second request message to the home subscriber server HSS according to the first request message, to request the HSS to expose an MBMS capability.", "The SCEF sends a third request message to the broadcast multicast service center BM-SC after the SCEF receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request first MBMS capability information exposed by the BM-SC.", "The SCEF sends the exposed first MBMS capability information obtained from the BM-SC to the third-party server, so that the third-party server starts an MBMS broadcast according to the exposed first MBMS capability information and distributes video content to the user equipment UE.", "That is, when multiple UEs access the video content, the third-party server providing the video content may interact with an SCEF of a 3GPP network and the BM-SC, and negotiates with the BM-SC to determine a to-be-exposed MBMS capability according to the MBMS capability negotiation parameter.", "The third-party server redirects requests of the UEs to a broadcast reception mode of the 3GPP, to receive the video content, so as to expand the MBMS capability to OTT video supporting.", "In this way, an OTT third party does not need to perform negotiation and testing with different operators or different terminals, and technical difficulty of the OTT third party in providing a video service is reduced.", "Therefore, problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network can be resolved." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of International Application No.", "PCT/CN2015/084530, filed on Jul.", "20, 2015, which is hereby incorporated by reference in the entirety.", "TECHNICAL FIELD The present application relates to the communications field, and in particular, to a video distribution method and a device.", "BACKGROUND OTT (Over The Top) means that an Internet company develops, by bypassing an operator, various open Internet-based video and data serving services, that is, only a network transmission capability of the operator is used, and a third party other than the operator provides an Internet television service or the like.", "In an existing service and capability exposure (Service Exposure and Enablement Support, SEES) technology, an OTT third party (for example, Sohu video, LeTV, Baidu browser, or Tencent WeChat) may provide, by using a network transmission capability, a 3rd Generation Partnership Project (3GPP) network with a time period for requesting data, a volume of data sent in a specified region, quality of service (QoS), a priority, and the like.", "The 3GPP network sends, according to a request of the OTT third party, specified data according to QoS and a priority of network authorization in a specified region, and provides the OTT third party with a recommended time period, charging policy information, network anomaly information, status information of user equipment (UE), and the like.", "If the operator supports an OTT video, none of multimedia broadcast multicast service (MBMS) supporting capabilities of the 3GPP network that include a media format support capability, a media distribution capability, a caching/transcoding capability, and an advertisement insertion capability are described in an existing 3GPP network capability exposure framework.", "In this way, the operator needs to perform interoperability testing with each OTT third party and develop and customize a video support capability for each OTT third party.", "For the OTT third party, because each operator has a different MBMS capability, if the OTT third party does not use an MBMS video support capability of the 3GPP network, the OTT third party still needs to perform interoperability testing with each operator, to adapt to different operator pipes and video supporting capabilities of different terminals.", "This increases IOT (interoperability testing) workload of the OTT third party, causing heavy video distribution and management load.", "SUMMARY Embodiments of the present invention provide a video distribution method and a device, so as to resolve problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network.", "According to a first aspect, a video distribution method is provided, including: receiving, by a service capability exposure function SCEF, a first request message sent by a third-party server, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; sending, by the SCEF, a second request message to a home subscriber server HSS according to the first request message, to request the HSS to expose an MBMS capability; sending, by the SCEF, a third request message to a broadcast multicast service center BM-SC after the SCEF receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request first MBMS capability information exposed by the BM-SC; and sending, by the SCEF, the first MBMS capability information obtained from the BM-SC to the third-party server, to enable the-third party server to request, according to the first MBMS capability information, to start an MBMS broadcast, and distributes video content to user equipment UE.", "With reference to the first aspect, in a first possible implementation of the first aspect, the first request message further includes port information of the third-party server and media encoding information of the third-party server; the second request message includes the MBMS capability negotiation parameter and/or an MBMS media capability exposure request indication, and the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability; if the second request message includes the MBMS capability negotiation parameter, the second response message includes second MBMS capability information that is to be exposed and that is determined by the HSS according to subscription information between the HSS and an operator and the MBMS capability negotiation parameter; or if the second request message includes the MBMS media capability exposure request indication, the second response message includes an MBMS capability exposure request indication, and the MBMS capability exposure request indication is used to request the first MBMS capability information exposed and determined by the BM-SC; the third request message includes the port information of the third-party server and the media encoding information of the third-party server; and if the second response message includes the second MBMS capability information, the third request message further includes the second MBMS capability information; or if the second response message does not include the second MBMS capability information, the third request message further includes the MBMS capability negotiation parameter.", "With reference to the first possible implementation of the first aspect, in a second possible implementation of the first aspect, before the sending, by the SCEF, the first MBMS capability information obtained from the BM-SC to the third-party server, the method further includes: receiving, by the SCEF, a third response message sent by the BM-SC, where the third response message includes the first MBMS capability information, a service portal link for transporting the video content, port information of the BM-SC, a charging rule, and media encoding information of the BM-SC.", "With reference to the second possible implementation of the first aspect, in a third possible implementation of the first aspect, the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported; and the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "According to a second aspect, a video distribution method is provided, including: sending, by a third-party server, a first request message to a service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; receiving, by the third-party server, a first response message sent by the SCEF, where the first response message includes exposed MBMS capability information obtained by the SCEF and a service portal link that is used for transporting video content and that is obtained from a broadcast multicast service center BM-SC; and sending, by the third-party server to the UE, the service portal link for transporting the video content, and requesting, according to the MBMS capability information, to start an MBMS broadcast to distribute the video content to the UE.", "With reference to the second aspect, in a first possible implementation of the second aspect, the MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported; the first request message further includes port information of the third-party server and media encoding information of the third-party server; and the first response message further includes port information of the BM-SC, media encoding information of the BM-SC, and a charging rule that are obtained by the SCEF; where the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "With reference to the second aspect or the first possible implementation of the second aspect, in a second possible implementation of the second aspect, before the sending, by a third-party server, a first request message to an SCEF, or after the receiving, by the third-party server, a first response message sent by the SCEF, the method further includes: receiving, by the third-party server, Hypertext Transfer Protocol HTTP request messages sent by at least two UEs, where the HTTP request message is used to request same video content.", "With reference to the second aspect or the first possible implementation or the second possible implementation of the second aspect, in a third possible implementation of the second aspect, after the sending, by the third-party server to user equipment UE, the service portal link for transporting the video content, the method further includes: sending, by the third-party server, the video content to the BM-SC or the SCEF.", "According to a third aspect, a video distribution method is provided, including: receiving, by a broadcast multicast service center BM-SC, a first request message sent by a service capability exposure function SCEF, where the first request message is used to obtain multimedia broadcast multicast service MBMS capability information during video content distribution; and sending, by the BM-SC, a first response message to the SCEF, where the first response message includes first MBMS capability information exposed by the BM-SC, so as to distribute video content to user equipment UE after the SCEF starts an MBMS broadcast according to the first MBMS capability information.", "With reference to the third aspect, in a first possible implementation of the third aspect, the first request message includes an MBMS capability negotiation parameter for video distribution and that is requested by a third-party server, or the first request message includes second MBMS capability information that is to be exposed and that is determined by a home subscriber server HSS according to the MBMS capability negotiation parameter obtained from the third-party server; and before the sending, by the BM-SC, a first response message to the SCEF, the method further includes: determining, by the BM-SC according to the MBMS capability negotiation parameter and subscription information between the BM-SC and an operator, the first MBMS capability information exposed by the BM-SC; or determining, by the BM-SC according to the second MBMS capability information that is to be exposed and that is determined by the HSS and subscription information between the BM-SC and the operator, the first MBMS capability information exposed by the BM-SC.", "With reference to the third aspect or the first possible implementation of the third aspect, in a second possible implementation of the third aspect, the first request message further includes port information of the third-party server and media encoding information of the third-party server; and the first response message includes port information of the BM-SC, a service portal link for transporting the video content, a charging rule, and media encoding information of the BM-SC; and the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "With reference to the second possible implementation of the third aspect, in a third possible implementation of the third aspect, the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "With reference to the second possible implementation or the third possible implementation of the third aspect, in a fourth possible implementation of the third aspect, after the sending, by the BM-SC, a first response message to the SCEF, the method further includes: sending, by the BM-SC to the UE, the service portal link for transporting the video content; and receiving, by the BM-SC according to the port information of the BM-SC, video content sent by the third-party server, and sending the video content to the UE.", "According to a fourth aspect, a video distribution method is provided, including: receiving, by a home subscriber server HSS, a first request message sent by a service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution and that is sent by a third-party server AS by using the SCEF, and/or an MBMS media capability exposure request indication sent by the SCEF, where the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability; and determining, by the HSS according to subscription information between the HSS and an operator, and the MBMS capability negotiation parameter and/or the MBMS media capability exposure request, whether to allow the exposure of the MBMS capability.", "With reference to the fourth aspect, in a first possible implementation of the fourth aspect, if the first request message includes the MBMS capability negotiation parameter, when the HSS determines to allow the exposure of the MBMS capability, the method further includes: determining, by the HSS, exposed MBMS capability information according to the subscription information and the MBMS capability negotiation parameter; and sending, by the HSS, a first response message to the SCEF, where the first response message includes the MBMS capability information, where if the first request message includes the MBMS media capability exposure request indication, and the HSS determines to allow the exposure of the MBMS capability, the first response message includes an MBMS capability exposure request indication, to notify the SCEF that the exposure of the MBMS capability is allowed.", "With reference to the first possible implementation of the fourth aspect, in a second possible implementation, the MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "According to a fifth aspect, a service capability exposure function SCEF is provided, including: a receiving unit, configured to receive a first request message sent by a third-party server, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; and a sending unit, configured to send a second request message to a home subscriber server HSS according to the first request message, to request the HSS to expose an MBMS capability, where the sending unit is further configured to send a third request message to a broadcast multicast service center BM-SC when the receiving unit receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request first MBMS capability information exposed by the BM-SC; and the sending unit is further configured to send the first MBMS capability information obtained from the BM-SC to the third-party server, to enable the-third party server to request, according to the first MBMS capability information, to start an MBMS broadcast, and distributes video content to user equipment UE.", "With reference to the fifth aspect, in a first possible implementation of the fifth aspect, the first request message further includes port information of the third-party server and media encoding information of the third-party server; the second request message includes the MBMS capability negotiation parameter and/or an MBMS media capability exposure request indication, and the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability; if the second request message includes the MBMS capability negotiation parameter, the second response message includes second MBMS capability information that is to be exposed and that is determined by the HSS according to subscription information between the HSS and an operator and the MBMS capability negotiation parameter; or if the second request message includes the MBMS media capability exposure request indication, the second response message includes an MBMS capability exposure request indication, and the MBMS capability exposure request indication is used to request the first MBMS capability information exposed and determined by the BM-SC; the third request message includes the port information of the third-party server and the media encoding information of the third-party server; and if the second response message includes the second MBMS capability information, the third request message further includes the second MBMS capability information; or if the second response message does not include the second MBMS capability information, the third request message further includes the MBMS capability negotiation parameter.", "With reference to the first possible implementation of the fifth aspect, in a second possible implementation of the fifth aspect, the receiving unit is further configured to: receive a third response message sent by the BM-SC, where the third response message includes the first MBMS capability information, a service portal link for transporting the video content, port information of the BM-SC, a charging rule, and media encoding information of the BM-SC.", "With reference to the first possible implementation of the fifth aspect, in a second possible implementation of the fifth aspect, the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported; and the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "According to a sixth aspect, a third-party server is provided, including: a sending unit, configured to send a first request message to a service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; a receiving unit, configured to receive a first response message sent by the SCEF, where the first response message includes exposed MBMS capability information obtained by the SCEF and a service portal link that is used for transporting video content and that is obtained from a broadcast multicast service center BM-SC, where the sending unit is further configured to send, to the UE, the service portal link for transporting the video content; and a processing unit, configured to request, according to the MBMS capability information, to start an MBMS broadcast to distribute the video content to the UE.", "With reference to the sixth aspect, in a first possible implementation of the sixth aspect, the MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported; the first request message further includes port information of the third-party server and media encoding information of the third-party server; and the first response message further includes port information of the BM-SC, media encoding information of the BM-SC, and a charging rule that are obtained by the SCEF; where the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "With reference to the sixth aspect or the first possible implementation of the sixth aspect, in a second possible implementation of the sixth aspect, the receiving unit is further configured to: before the third-party server sends the first request message to the SCEF, or after the third-party server receives the first response message sent by the SCEF, receive Hypertext Transfer Protocol HTTP request messages sent by at least two UEs, where the HTTP request message is used to request same video content.", "With reference to the sixth aspect or the first possible implementation or the second possible implementation of the sixth aspect, in a third possible implementation of the sixth aspect, the sending unit is further configured to: after sending, to the user equipment UE, the service portal link for transporting the video content, send the video content to the BM-SC or the SCEF.", "According to a seventh aspect, a broadcast multicast service center BM-SC is provided, including: a receiving unit, configured to receive a first request message sent by a service capability exposure function SCEF, where the first request message is used to obtain multimedia broadcast multicast service MBMS capability information during video content distribution; and a sending unit, configured to send a first response message to the SCEF, where the first response message includes first MBMS capability information exposed by the BM-SC, so as to distribute video content to user equipment UE after the SCEF starts an MBMS broadcast according to the first MBMS capability information.", "With reference to the seventh aspect, in a first possible implementation of the seventh aspect, the first request message includes an MBMS capability negotiation parameter for video distribution and that is requested by a third-party server, or the first request message includes second MBMS capability information that is to be exposed and that is determined by a home subscriber server HSS according to the MBMS capability negotiation parameter obtained from the third-party server; and the BM-SC further includes: a processing unit, configured to determine, according to the MBMS capability negotiation parameter and subscription information between the BM-SC and an operator, the first MBMS capability information exposed by the BM-SC; or the processing unit is configured to determine, according to the second MBMS capability information that is to be exposed and that is determined by the HSS and subscription information between the BM-SC and the operator, the first MBMS capability information exposed by the BM-SC.", "With reference to the seventh aspect or the first possible implementation of the seventh aspect, in a second possible implementation of the seventh aspect, the first request message further includes port information of the third-party server and media encoding information of the third-party server; and the first response message includes port information of the BM-SC, a service portal link for transporting the video content, a charging rule, and media encoding information of the BM-SC; and the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "With reference to the second possible implementation of the seventh aspect, in a third possible implementation of the seventh aspect, the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "With reference to the second possible implementation or the third possible implementation of the seventh aspect, in a fourth possible implementation of the seventh aspect, the sending unit is further configured to: send, to the UE, the service portal link for transporting the video content; the receiving unit is further configured to receive, according to the port information of the BM-SC, video content sent by the third-party server; and the sending unit is further configured to send the video content to the UE.", "According to an eighth aspect, a home subscriber server HSS is provided, including: a receiving unit, configured to receive a first request message sent by a service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution and that is sent by a third-party server AS by using the SCEF, and/or an MBMS media capability exposure request indication sent by the SCEF, where the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability; and a processing unit, configured to determine, according to subscription information between the HSS and an operator, and the MBMS capability negotiation parameter and/or the MBMS media capability exposure request, whether to allow the exposure of the MBMS capability.", "With reference to the eighth aspect, in a first possible implementation of the eighth aspect, if the first request message includes the MBMS capability negotiation parameter, the processing unit is further configured to determine exposed MBMS capability information according to the subscription information and the MBMS capability negotiation parameter; and the HSS further includes a sending unit, configured to send a first response message to the SCEF, where the first response message includes the MBMS capability information, where if the first request message includes the MBMS media capability exposure request indication, and the HSS determines to allow the exposure of the MBMS capability, the first response message includes an MBMS capability exposure request indication, to notify the SCEF that the exposure of the MBMS capability is allowed.", "With reference to the first possible implementation of the eighth aspect, in a second possible implementation of the eighth aspect, the MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "According to a ninth aspect, a service capability exposure function SCEF is provided, including: a receiver, configured to receive a first request message sent by a third-party server, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; and a transmitter, configured to send a second request message to a home subscriber server HSS according to the first request message, to request the HSS to expose an MBMS capability, where the transmitter is further configured to send a third request message to a broadcast multicast service center BM-SC when the receiver receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request first MBMS capability information exposed by the BM-SC; and the transmitter is further configured to send the first MBMS capability information obtained from the BM-SC to the third-party server, to enable the-third party server to request, according to the first MBMS capability information, to start an MBMS broadcast, and distributes video content to user equipment UE.", "With reference to the ninth aspect, in a first possible implementation of the ninth aspect, the first request message further includes port information of the third-party server and media encoding information of the third-party server; the second request message includes the MBMS capability negotiation parameter and/or an MBMS media capability exposure request indication, and the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability; if the second request message includes the MBMS capability negotiation parameter, the second response message includes second MBMS capability information that is to be exposed and that is determined by the HSS according to subscription information between the HSS and an operator and the MBMS capability negotiation parameter; or if the second request message includes the MBMS media capability exposure request indication, the second response message includes an MBMS capability exposure request indication, and the MBMS capability exposure request indication is used to request the first MBMS capability information exposed and determined by the BM-SC; the third request message includes the port information of the third-party server and the media encoding information of the third-party server; and if the second response message includes the second MBMS capability information, the third request message further includes the second MBMS capability information; or if the second response message does not include the second MBMS capability information, the third request message further includes the MBMS capability negotiation parameter.", "With reference to the first possible implementation of the ninth aspect, in a second possible implementation of the ninth aspect, the receiver is further configured to receive a third response message sent by the BM-SC, where the third response message includes the first MBMS capability information, a service portal link for transporting the video content, port information of the BM-SC, a charging rule, and media encoding information of the BM-SC.", "With reference to the second possible implementation of the ninth aspect, in a third possible implementation of the ninth aspect, the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported; and the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "According to a tenth aspect, a third-party server is provided, including: a transmitter, configured to send a first request message to a service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; a receiver, configured to receive a first response message sent by the SCEF, where the first response message includes exposed MBMS capability information obtained by the SCEF and a service portal link that is used for transporting video content and that is obtained from a broadcast multicast service center BM-SC, where the transmitter is further configured to send, to the UE, the service portal link for transporting the video content; and a processor, configured to request, according to the MBMS capability information, to start an MBMS broadcast to distribute the video content to the UE.", "With reference to the tenth aspect, in a first possible implementation of the tenth aspect, the MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported; the first request message further includes port information of the third-party server and media encoding information of the third-party server; and the first response message further includes port information of the BM-SC, media encoding information of the BM-SC, and a charging rule that are obtained by the SCEF; where the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "With reference to the tenth aspect or the first possible implementation of the tenth aspect, in a second possible implementation of the tenth aspect, the receiver is further configured to: before the transmitter sends the first request message to the SCEF, or after the receiver receives the first response message sent by the SCEF, receive Hypertext Transfer Protocol HTTP request messages sent by at least two UEs, where the HTTP request message is used to request same video content.", "With reference to the tenth aspect or the first possible implementation or the second possible implementation of the tenth aspect, in a third possible implementation of the tenth aspect, the transmitter is further configured to: after sending, to the user equipment UE, the service portal link for transporting the video content, send the video content to the BM-SC or the SCEF.", "According to an eleventh aspect, a broadcast multicast service center BM-SC is provided, including: a receiver, configured to receive a first request message sent by a service capability exposure function SCEF, where the first request message is used to obtain multimedia broadcast multicast service MBMS capability information during video content distribution; and a transmitter, configured to send a first response message to the SCEF, where the first response message includes first MBMS capability information exposed by the BM-SC, so as to distribute video content to user equipment UE after the SCEF starts an MBMS broadcast according to the first MBMS capability information.", "With reference to the eleventh aspect, in a first possible implementation of the eleventh aspect, the first request message includes an MBMS capability negotiation parameter for video distribution and that is requested by a third-party server, or the first request message includes second MBMS capability information that is to be exposed and that is determined by a home subscriber server HSS according to the MBMS capability negotiation parameter obtained from the third-party server; and the BM-SC further includes: a processor, configured to: determine, according to the MBMS capability negotiation parameter and subscription information between the BM-SC and an operator, the first MBMS capability information exposed by the BM-SC; or determine, according to the second MBMS capability information that is to be exposed and that is determined by the HSS and subscription information between the BM-SC and the operator, the first MBMS capability information exposed by the BM-SC.", "With reference to the eleventh aspect or the first possible implementation of the eleventh aspect, in a second possible implementation of the eleventh aspect, the first request message further includes port information of the third-party server and media encoding information of the third-party server; and the first response message includes port information of the BM-SC, a service portal link for transporting the video content, a charging rule, and media encoding information of the BM-SC; and the port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "With reference to the second possible implementation of the eleventh aspect, in a third possible implementation of the eleventh aspect, the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "With reference to the second possible implementation or the third possible implementation of the eleventh aspect, in a fourth possible implementation of the eleventh aspect, the transmitter is further configured to send, to the UE, the service portal link for transporting the video content; and the receiver is further configured to receive, according to the port information of the BM-SC, video content sent by the third-party server; and the transmitter is further configured to send the video content to the UE.", "According to a twelfth aspect, a home subscriber server HSS is provided, including: a receiver, configured to receive a first request message sent by a service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution and that is sent by a third-party server AS by using the SCEF, and/or an MBMS media capability exposure request indication sent by the SCEF, where the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability; and a processor, configured to determine, according to subscription information between the HSS and an operator, and the MBMS capability negotiation parameter and/or the MBMS media capability exposure request, whether to allow the exposure of the MBMS capability.", "With reference to the twelfth aspect, in a first possible implementation of the twelfth aspect, if the first request message includes the MBMS capability negotiation parameter, when the processor is configured to determine to allow the exposure of the MBMS capability, the processor is further configured to determine exposed MBMS capability information according to the subscription information and the MBMS capability negotiation parameter; and the transmitter is further configured to send a first response message to the SCEF, where the first response message includes the MBMS capability information, where if the first request message includes the MBMS media capability exposure request indication, and the HSS determines to allow the exposure of the MBMS capability, the first response message includes an MBMS capability exposure request indication, to notify the SCEF that the exposure of the MBMS capability is allowed.", "With reference to the first possible implementation of the twelfth aspect, in a second possible implementation of the twelfth aspect, the MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "The embodiments of the present invention provide a video distribution method and a device.", "The SCEF receives a first request message sent by the third-party server, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server, and sends a second request message to the home subscriber server HSS according to the first request message, to request the HSS to expose an MBMS capability.", "The SCEF sends a third request message to the broadcast multicast service center BM-SC after the SCEF receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request first MBMS capability information exposed by the BM-SC.", "The SCEF sends the exposed first MBMS capability information obtained from the BM-SC to the third-party server, so that the third-party server starts an MBMS broadcast according to the exposed first MBMS capability information and distributes video content to the user equipment UE.", "That is, when multiple UEs access the video content, the third-party server providing the video content may interact with an SCEF of a 3GPP network and the BM-SC, and negotiates with the BM-SC to determine a to-be-exposed MBMS capability according to the MBMS capability negotiation parameter.", "The third-party server redirects requests of the UEs to a broadcast reception mode of the 3GPP, to receive the video content, so as to expand the MBMS capability to OTT video supporting.", "In this way, an OTT third party does not need to perform negotiation and testing with different operators or different terminals, and technical difficulty of the OTT third party in providing a video service is reduced.", "Therefore, problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network can be resolved.", "BRIEF DESCRIPTION OF DRAWINGS To describe the technical solutions in the embodiments of the present invention or in the prior art more clearly, the following briefly describes the accompanying drawings required for describing the embodiments or the prior art.", "Apparently, the accompanying drawings in the following description show merely some embodiments of the present invention, and a person of ordinary skill in the art may still derive other drawings from these accompanying drawings without creative efforts.", "FIG.", "1 is a schematic flowchart of a video distribution method according to an embodiment of the present invention; FIG.", "2A and FIG.", "2B are a schematic flowchart of a video distribution method according to an embodiment of the present invention; FIG.", "3A and FIG.", "3B are a schematic information interaction diagram of a video distribution method according to an embodiment of the present invention; FIG.", "4A and FIG.", "4B are a schematic flowchart of a video distribution method according to an embodiment of the present invention; FIG.", "5 is a schematic information interaction diagram of a video distribution method according to an embodiment of the present invention; FIG.", "6 is a schematic flowchart of a video distribution method according to an embodiment of the present invention; FIG.", "7 is a schematic flowchart of a video distribution method according to an embodiment of the present invention; FIG.", "8 is a schematic flowchart of a video distribution method according to an embodiment of the present invention; FIG.", "9 is a schematic structural diagram of an SCEF according to an embodiment of the present invention; FIG.", "10 is a schematic structural diagram of a third-party server according to an embodiment of the present invention; FIG.", "11 is a schematic structural diagram of a BM-SC according to an embodiment of the present invention; FIG.", "12 is a schematic structural diagram of an HSS according to an embodiment of the present invention; FIG.", "13 is a schematic structural diagram of an SCEF according to an embodiment of the present invention; FIG.", "14 is a schematic structural diagram of a third-party server according to an embodiment of the present invention; FIG.", "15 is a schematic structural diagram of a BM-SC according to an embodiment of the present invention; and FIG.", "16 is a schematic structural diagram of an HSS according to an embodiment of the present invention.", "DESCRIPTION OF EMBODIMENTS The following clearly describes the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention.", "Apparently, the described embodiments are merely some but not all of the embodiments of the present invention.", "All other embodiments obtained by a person of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present application.", "The embodiments of the present invention may be applied to a multimedia broadcast multicast service MBMS architecture of an evolved packet system (EPS).", "The MBMS is a point-to-multipoint service, can implement data transmission from a single entity to multiple receivers, and may include the following network elements and devices: UE supports an activation/deactivation function of an MBMS bearer service.", "A packet data network gateway (P-GW) is a user plane anchor between a 3GPP access network and a non-3GPP access network, and an interface with an external packet data network.", "A broadcast multicast service center (BM-SC) is used for charging record generation, member management, MBMS session and transmission management, service notification management, MBMS transmission security support, MBMS session transmission and retransmission schedule determining, identification of each MBMS session, temporary mobile group identity (TMGI) allocation, MBMS bearer resource initiation or termination, and MBMS data sending, and has an error resilience policy, or the like.", "In a capability exposure architecture, a service capability exposure function (SCEF) is located between a 3GPP network and a service capability server (SCS)/third-party server (Application Server, AS), and the SCS/AS may initiates a service capability request to the SCEF by using an application programming interface (API) or the SCS/AS directly initiates a request to a network entity.", "The SCEF requests a corresponding network capability from the 3GPP network, and then the SCEF sends the obtained network capability/a result to the SCS/AS by using the API.", "For broadcast capability exposure, the SCEF is connected to the BM-SC by using an interface, the AS requests allocation/release of a TMGI also by using the interface, to activate/deactivate/modify an MBMS bearer, and the BM-SC notifies MBMS status information to the AS by using the interface.", "Based on the foregoing MBMS architecture and capability exposure architecture, an embodiment of the present invention provides a video distribution method.", "As shown in FIG.", "1, the method includes the following steps.", "101.An SCEF receives a first request message sent by a third-party server, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server.", "For an operator, the third-party server may be referred to the foregoing SCS/AS.", "For a user, the third-party server may be referred to as an OTT video server, providing video content to the user.", "Before the SCEF receives the first request message sent by the third-party server, UE may first access the OTT video server.", "After detecting that at least two UEs access same video content, the OTT video server interacts with an SCEF of a 3GPP, and sends, to the SCEF, the first request message to request for invoking an MBMS video support capability of a 3GPP network.", "The first request message includes an MBMS capability negotiation parameter for video distribution and that is requested by the OTT video server, for example, a transport mode indication of the video content, a security feature indication of an MBMS, an indication showing that content caching is supported, or an indication showing that content caching is not supported.", "Alternatively, the OTT video server may request in advance an MBMS capability exposure resource from a 3GPP network, to send the first request message to the SCEF.", "In this way, when detecting that at least two UEs access same video content, the OTT video server may redirect requests of the UEs to a broadcast reception mode, to receive the video content.", "Alternatively, policy information is preconfigured in the third-party server, and when receiving an HTTP request sent by the UE, the third-party server sends the first request message to the SCEF.", "This is not limited in the present disclosure.", "The first request message may further include port information of the third-party server and media encoding information of the third-party server.", "The port information of the third-party server is used for trusted channel data transmission between the third-party server and a BM-SC.", "The media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "102.The SCEF sends a second request message to a home subscriber server HSS according to the first request message, to request the HSS to expose an MBMS capability.", "The SCEF adds the MBMS capability negotiation parameter and/or an MBMS media capability exposure request indication in the first request message to a second request message, and sends the second request message to a home subscriber server (HSS).", "The MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability.", "Therefore, the HSS may check subscription information between the HSS and an operator, to determine whether the MBMS capability is allowed to be exposed to an OTT third party.", "If the HSS performs MBMS capability determining, the HSS determines, for example, whether to expose the MBMS pipe capability, whether to expose a media capability (including a content caching capability, a media transcoding capability, or the like), or whether to expose an advertisement insertion capability.", "103.The SCEF sends a third request message to a BM-SC after the SCEF receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request first MBMS capability information exposed by the BM-SC.", "When determining to expose the MBMS capability, the HSS returns the second response message to the SCEF, to represent that the MBMS capability is allowed to be exposed to the OTT third party.", "If the second request message includes the MBMS capability negotiation parameter, when the HSS allows the exposure of the MBMS capability, the second response message includes second MBMS capability information that is to be exposed and that is determined by the HSS according to subscription information between the HSS and an operator and the MBMS capability negotiation parameter.", "If the second response message includes the second MBMS capability information, the third request message further includes the second MBMS capability information, that is, the BM-SC determines the first MBMS capability information according to the second MBMS capability information determined by the HSS and the subscription information between the BM-SC and the operator.", "If the second request message includes the MBMS media capability exposure request indication, the second response message includes an MBMS capability exposure request indication, and the MBMS capability exposure request indication is used to request the first MBMS capability information exposed and determined by the BM-SC.", "In this case, if the second request message further includes the MBMS capability negotiation parameter, the first MBMS capability information in the second response message is determined by the BM-SC according to the second MBMS capability information determined by the HSS.", "If the second response message does not include the second MBMS capability information, the third request message further includes the MBMS capability negotiation parameter, that is, the HSS does not perform MBMS capability determining, but the BM-SC directly determines to-be-exposed first MBMS capability information according to the MBMS capability negotiation parameter and the subscription information between the BM-SC and the operator only when the HSS determines to allow the exposure of the MBMS capability.", "The MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "104.The SCEF sends the exposed first MBMS capability information obtained from the BM-SC to the third-party server, to enable the-third party server to request, according to the first MBMS capability information, to start an MBMS broadcast, and distributes video content to user equipment UE.", "Before the sending, by the SCEF, the first MBMS capability information obtained from the BM-SC to the third-party server, the method further includes: receiving, by the SCEF, a third response message sent by the BM-SC, where the third response message includes the first MBMS capability information, a service portal link for transporting the video content, port information of the BM-SC, a charging rule, and media encoding information of the BM-SC.", "The service portal link for transporting the video content may be a user service description (USD) uniform resource locator (URL) provided by the BM-SC, or a domain name address of the BM-SC, or the like.", "The port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server.", "The SCEF then sends the first MBMS capability information obtained from the BM-SC, the service portal link for transporting the video content, the port information of the BM-SC, the charging rule, and the media encoding information of the BM-SC to the third-party server.", "In this way, the third-party server requests the 3GPP network to start an MBMS broadcast, and notifies the video content to the UE according to the MBMS capability information exposed by the BM-SC, that is, redirects a request of the UE to an MBMS broadcast reception mode, to receive the video content, so as to expand the MBMS capability to OTT video supporting.", "In this way, technical difficulty of the OTT third party in providing a video service is reduced, the OTT third party does not need to perform negotiation and testing with different operators or different terminal types separately, and workload of the OTT third party is reduced.", "This embodiment of the present invention provides a video distribution method.", "The SCEF receives a first request message sent by the third-party server, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server, and sends a second request message to the home subscriber server HSS according to the first request message, to request the HSS to expose an MBMS capability.", "The SCEF sends a third request message to the broadcast multicast service center BM-SC after the SCEF receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request first MBMS capability information exposed by the BM-SC.", "The SCEF sends the exposed first MBMS capability information obtained from the BM-SC to the third-party server, so that the third-party server starts an MBMS broadcast according to the exposed first MBMS capability information and distributes video content to the user equipment UE.", "That is, when multiple UEs access the video content, the third-party server providing the video content may interact with an SCEF of a 3GPP and the BM-SC, and negotiates with the BM-SC to determine a to-be-exposed MBMS capability according to the MBMS capability negotiation parameter.", "The third-party server redirects requests of the UEs to a broadcast reception mode, to receive the video content, so as to expand the MBMS capability to OTT video supporting.", "In this way, an OTT third party does not need to perform negotiation and testing with different operators or different terminals, and technical difficulty of the OTT in providing a video service is reduced.", "Therefore, problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network can be resolved.", "Based on the foregoing embodiment, the following specifically describes an embodiment of the present invention.", "For a scenario in which an OTT video server requests, after detecting that at least two UEs access same video content, a 3GPP network to expose an MBMS capability, another embodiment of the present invention provides a video distribution method.", "As shown in FIG.", "2, the method includes the following steps.", "201.A third-party server detects that at least two UEs access same video content.", "For example, UE 1 sends an HTTP request message to the third-party server, to request to send video content.", "The HTTP request message includes a URL corresponding to the video content.", "UE 2 also sends an HTTP request message to the third-party server, and also requests, from the third-party server, the video content corresponding to the same URL.", "Therefore, the third-party server detects, according to the URL, that multiple UEs access the same video content.", "Then the third-party server determines to invoke a video capability of a 3GPP network to distribute the video content.", "202.The third-party server sends a first TMGI allocation request to an SCEF, where the TMGI allocation request includes an MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server.", "The MBMS capability negotiation parameter for video distribution is added to an existing TMGI allocation request (Allocate TMGI Request) by using a standard open interface and by using the TMGI allocation request.", "That is, the first TMGI allocation request herein is equivalent to the first request message in the foregoing embodiment.", "The first TMGI allocation request includes the MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server.", "The MBMS capability negotiation parameter may include: a transport mode indication of the video content.", "The transport mode indication may include a broadcast mode (Broad Cast only), or a broadcast/unicast hybrid mode (hybrid Broad Cast/Unitary Cast, hybrid BC/UC), or a dynamic broadcast/unicast mode (dynamic BC/UC), that is, a mode dynamically switching between a broadcast mode and a unicast mode; may further include a security feature indication for using the MBMS (MBMS security feature allowed), where the security feature indication is an enabled state or a disabled state; may further include a content transcoding capability support indication (content transcoding capability support), which includes an indication showing that transcoding is supported or an indication showing that transcoding is not supported; may further include a content caching indication (caching support), which includes an indication showing that content caching is supported or an indication showing that content caching is not supported; may further include an advertisement insertion capability indication, where the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported; may further include quality of experience (QoE) reporting indication, where the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; may further include a network information reporting indication, where the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, and the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; or may further include an advertisement purchasing information indication, where the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "The first TMGI allocation request may further include port information (SCS port information) of the third-party server, for example, an IP address and a port number of an SCS, used for trusted channel data transmission between the third-party server and the BM-SC; may further include media encoding information (media layer information) of the third party server, including, for example, video encoding information, such as video H.264/H.265; and audio encoding information, such as adaptive multi-rate wideband coding (AMR-WB), adaptive multi-rate narrowband coding (AMR-NB), or an enhanced voice service (EVS); or may further include other media information, for example, text encoding information, or picture encoding information.", "Certainly, the first TMGI allocation request further includes a group identifier (external group ID), an SCS ID, UE IDs, and the like of video content already existing in the request.", "203.The SCEF sends a subscription information request to an HSS, to request the HSS to expose an MBMS capability.", "When receiving the first TMGI allocation request, the SCEF sends, to the HSS, a subscription information request, which is equivalent to the second request message in the foregoing embodiment.", "The subscription information request may carry the MBMS capability negotiation parameter and/or an MBMS media capability exposure request indication.", "The MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability, or may further include an external group ID, an SCS ID, and the like, so as to request the HSS to expose the MBMS capability to an OTT third party, for example, Sohu video, or LeTV.", "204.The HSS detects subscription information, determines whether to allow the exposure of the MBMS capability to an OTT third party, and sends a subscription information response to the SCEF.", "According to the description of step 203, the subscription information request may include the MBMS capability negotiation parameter, or the MBMS media capability exposure request indication, or the MBMS capability negotiation parameter and the MBMS media capability exposure request indication; or the subscription information request indicates that no parameter or indication is added.", "When the subscription information request indicates that no parameter or indication is added, if the HSS receives the subscription information request, the subscription information request may determine, according to subscription information between the HSS and the operator, that is, an external group ID, an SCS ID, and the like, whether to expose the MBMS capability to the third party.", "If the HSS determines to expose the MBMS capability to the third party, the HSS sends, to the SCEF, a subscription information response representing that the exposure of the MBMS capability is allowed, and the subscription information response is also equivalent to the second response message in the foregoing embodiment.", "If the subscription information request includes the MBMS media capability exposure request indication and does not include the MBMS capability negotiation parameter, it may be understood that the MBMS pipe capability includes an MBMS media capability.", "When the HSS determines to allow the exposure of the MBMS pipe capability, because the MBMS capability negotiation parameter is not carried, a subscription information response including an MBMS capability exposure request indication is returned to the SCEF when no specific capability determining is performed to determine which media capability is to be exposed, so that the SCEF further requests the BM-SC exposed MBMS media capability information.", "If the subscription information request does not include the MBMS media capability exposure request indication, but includes the MBMS capability negotiation parameter, it may be understood that the MBMS pipe capability is represented in the MBMS capability negotiation parameter.", "If the HSS receives the subscription information request, when determining, according to the subscription information between the HSS and the operator, to expose the MBMS pipe capability, the HSS further determines, according to the MBMS capability negotiation parameter and the subscription information, which MBMS capability is to be exposed to a third party, and returns the determined MBMS capability information to the SCEF by using a subscription information response.", "If the subscription information request includes both the MBMS media capability exposure request indication and the MBMS capability negotiation parameter, it may be understood that the MBMS pipe capability and an MBMS media capability are in parallel, the HSS first determines, according to the subscription information, whether to expose the MBMS pipe capability.", "If the HSS determines to expose the MBMS pipe capability, the HSS further determines, according to the MBMS capability negotiation parameter and the subscription information, which MBMS capability is to be exposed, and returns, to the SCEF, a subscription information response that includes an MBMS capability exposure request indication and the determined to-be-exposed MBMS capability information, so that the SCEF further requests specific MBMS capability information from the BM-SC.", "An MBMS pipe represents a capability of data transmission between two nodes.", "205.The SCEF sends a second TMGI allocation request to a BM-SC, where the second TMGI allocation request is used to request to obtain exposed MBMS capability information from the BM-SC.", "When the SCEF determines that the HSS allows the exposure of the MBMS capability to the OTT third party, the SCEF sends, to the BM-SC, the second TMGI allocation request that is equivalent to the third request message in the foregoing embodiment.", "The MBMS capability negotiation parameter or the MBMS capability information that is determined to be exposed by the HSS is added to the second TMGI allocation request, or the foregoing SCS port information, media information, or the like may be further added to the second TMGI allocation request.", "That is, if the HSS does not specifically perform determining on the MBMS capability exposed to the third party, the SCEF sends the MBMS capability negotiation parameter obtained from the third-party server to the BM-SC, so that the BM-SC determines, according to the MBMS capability negotiation parameter and the subscription information between the BM-SC and the operator, which MBMS capability is specifically to be exposed.", "If the HSS performs capability determining according to the MBMS capability sent by the SCEF, to determine which MBMS is to be exposed to the third party, the BM-SC further determines, according to the subscription information between the BM-SC and the operator, and according to a set of MBMS capabilities in the MBMS capability information that is obtained from the SCEF and that is determined by the HSS, which MBMS capability is further exposed to the third party.", "206.The BM-SC determines the exposed MBMS capability information according to the subscription information between the BM-SC and an operator, and sends the MBMS capability information to the SCEF.", "The BM-SC determines specific exposed MBMS capability information, that is, arbitrates an exposure attribute based on a capability of the BM-SC.", "For example, the specific MBMS capability information includes a dynamic unicast/broadcast conversion capability and a media transcoding capability.", "In addition, the BM-SC returns the determined specific MBMS capability information to the SCEF.", "The specific MBMS capability information may be carried in the first TMGI allocation response message (allocate TMGI response).", "The BM-SC may provide, at the same time, port information of the BM-SC (BM-SC port information), a charging rule provided by the BM-SC, media encoding information of the BM-SC, and a service portal link that is used for transporting the video content and that is constructed by the BM-SC according to an arbitration result, for example, a USD URL; and further include an allocated TMGI or the like.", "207.The SCEF forwards the MBMS capability information to the third-party server.", "The SCEF may add the MBMS capability information, the charging rule, the port information of the BM-SC, the service portal link for transporting the video content, and the encoding information of the BM-SC that are received from the BM-SC to the second TMGI allocation response message, and forwards the second TMGI allocation response message to the third-party server SCS/AS.", "In this case, the third-party server is triggered to redirect a request of the UE to a broadcast reception mode, to receive the video content.", "For the foregoing description, it is assumed that the third-party server requests 10 capabilities (features) from the SCEF.", "According to different charging fees or an operator policy, the BM-SC provides only five of the capabilities, and then returns the five capabilities to the third-party server by using the SCEF.", "The third-party server can use only the five capabilities with the UE/BM-SC.", "For example, in a transport mode indication, there are three options for a transmission mode: a broadcast mode, a broadcast/unicast hybrid mode, and a dynamic broadcast/unicast mode.", "The broadcast mode means that the BM-SC provides only a broadcast capability, and only UE falling within a coverage area of the MBMS can receive media content, and UE falling outside the coverage area of the MBMS can only obtain media content from an OTT unicast server.", "The broadcast/unicast hybrid mode means that the 3GPP network provides a unicast/broadcast hybrid transmission capability, and when the UE falls outside the coverage area of the MBMS, the UE may obtain media content from a 3GPP network unicast server.", "In the dynamic broadcast/unicast mode, the UE can still obtain media content from the 3GPP network, but the 3GPP network selects an optimal transport manner to send the content to the UE.", "A difference between such a method and a hybrid unicast/broadcast mode lies in that: a coverage area of an MBMS in the hybrid unicast/broadcast mode is semi-static.", "After the coverage area of the MBMS is selected, although there is a small quantity of receiving users, the mode is still a broadcast mode, and although there is a large quantity of users outside the coverage area of the MBMS, media content can be obtained only in a unicast mode.", "For the dynamic unicast/broadcast mode, a broadcast mode or a unicast mode may be dynamically selected according to a user density status within an area, so that a network transmission capacity can be optimally used.", "When the OTT third party inquiries, by using a standard open interface, an operator network (SCEF) to query a video capability supported by the BM-SC, and negotiates with the operator network on the transmission mode, in a broadcast-only mode, the OTT still needs to configure a unicast server, while in the hybrid unicast/broadcast mode, the OTT does not need to configure a unicast server, but a 3GPP network capacity is not efficiently used.", "In the dynamic unicast/broadcast, use of the 3GPP network capacity is maximized.", "The three different transmission modes may correspond to different charging fees.", "For another example, for a content caching capability, if the OTT third party does not inquire, by using the standard open interface, the operator network (SCEF) to query the video capability supported by the BM-SC, and it is assumed that the BM-SC does not support the content caching capability, a subsequent unicast request of the UE is still provided by the OTT third party, the OTT third party needs to configure a large quantity of unicast servers, and needs a large server capacity.", "On the contrary, if the OTT third party interacts with the SCEF of the 3GPP network, to request for invoking an MBMS video support capability of the BM-SC of the 3GPP network, and the BM-SC supports the content caching capability, a subsequent unicast request of the UE is provided by a unicast server of the 3GPP network.", "The unicast server of the 3GPP network may obtain already cached content from the BM-SC, or the BM-SC provides 3GPP network unicast server supporting.", "In this case, the OTT third party does not need to be concerned with a problem of server capacity.", "It may be understood that the MBMS capability negotiation parameter and the MBMS capability information may be sent by using a single message.", "A process of starting an MBMS broadcast and distributing the video content according to the exposed MBMS capability information may be as follows: 208.The third-party server notifies, by means of HTTP interaction between the third-party server and UE, the UE of a service portal link for transporting the video content.", "209.The third-party server requests the SCEF to start an MBMS broadcast.", "The third-party server may specifically send, to the SCEF, a request message group message request, which may include an external group ID, an SCS ID, and the like.", "210.The SCEF performs, according to the foregoing context, authorization check on the request sent by the third-party server.", "211.If it is determined, according to the authorization check, to start the MBMS broadcast, the SCEF queries the HSS whether the third-party server can use an MBMS channel.", "Specifically, the SCEF may send, to the HSS, subscriber information request, which includes an external group ID, an SCS ID, and the like, so that the HSS determines, according to the subscription information, whether the third-party server can use an MBMS channel.", "212.If the HSS determines that the third-party server can use an MBMS channel, the HSS sends a determining response (subscriber information response) to the SCEF.", "213.The SCEF starts the MBMS broadcast.", "214.The SCEF sends an MBMS enabling acknowledgment message to the third-party server.", "If step 208 is not performed, step 215 may be performed after step 214, that is, the service portal link for transporting the video content may be notified to the UE by the third-party server or by the SCEF, and either of step 208 and step 215 may be selected.", "215.The SCEF communicates with the UE, and notifies the UE of the service portal link for transporting the video content, a UE-side MBMS client is ready, and the third-party server sends the video content to the BM-SC/SCEF.", "Optionally, in step 206, a USD URL constructed by the BM-SC may not need to be carried, but the domain name address of the BM-SC is carried.", "In this way, after the domain name address is notified to the UE by using the SCEF or the AS, the UE may parse the domain name address, and learn that the USD URL is obtained from the BM-SC.", "That is, the service portal link for transporting the video content may be the domain name address of the BM-SC.", "216.The SCEF sends a bearer activation request message (activate MBMS bearer request) to the BM-SC.", "217.The BM-SC establishes an MBMS bearer.", "218.The BM-SC sends an MBMS bearer establishment success message (activate MBMS bearer response) to the SCEF.", "219.The BM-SC starts a broadcast, and sends the content obtained from the third-party server to a broadcast bearer.", "220.The third-party server continuously pushes the video content to the BM-SC/SCEF.", "221.The UE obtains the video content by using an MBMS bearer.", "The UE obtains the video content by using the MBMS bearer according to an obtained service portal link USD URL of the video content that is provided by the BM-SC.", "It may be understood that, if the MBMS capability negotiation parameter sent by the third-party server to the SCEF further includes at least one of an indication showing that QoE is to be reported, an indication showing that network information is to be reported, or an indication showing that advertisement purchasing information is to be reported, after the third-party server distributes the video content to the UE by using the BM-SC or the SCEF, the BM-SC further needs to report at least one of QoE, network information, or advertisement purchasing information to the third-party server, or the UE reports such information to the third-party server by using the SCEF.", "This is not limited in the present disclosure.", "It should be noted that if media encoding information returned by the BM-SC is different from media encoding information requested by the third-party server, the third-party server needs to transcode the video content according to the media encoding information provided by the BM-SC.", "Certainly, if the BM-SC provides a content transcoding service, the third-party server may directly send the video content to the BM-SC, the BM-SC transcodes a media format to a content format supported by the UE, and then the BM-SC sends the content to the UE.", "For interaction between network elements in this embodiment, refer to FIG.", "3.Therefore, in this embodiment of the present invention, when the UE first accesses the third-party server, if the third-party server detects that multiple UEs access same video content, the third-party server interacts with an SCEF of a 3GPP network, to request for invoking an MBMS video support capability of the 3GPP network.", "The 3GPP network allows enabling of the MBMS video support capability, and then the third-party server redirects requests of the UEs to a broadcast reception mode, to receive the video content.", "By means of the present application, the MBMS capability may be expanded to OTT video supporting.", "In this way, an OTT third party does not need to perform negotiation and testing with different operators and different terminals, and technical difficulty of the OTT in providing a video service is reduced.", "This is equivalent to outsourcing video transmission work to an operator network by the OTT third party.", "By using an open transport and the MBMS capability negotiation parameter, the OTT third party does not need to perform negotiation and testing with different operators separately for parameters such as different pipes or video supporting capabilities of terminals.", "Therefore, problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network can be resolved.", "When a third-party server requests in advance a 3GPP network to expose an MBMS capability, another embodiment of the present invention provides a video distribution method.", "As shown in FIG.", "4, the method includes the following steps.", "401.A third-party server sends a first TMGI allocation request to an SCEF, where the first TMGI allocation request includes an MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server.", "402.The SCEF sends a subscription information request to an HSS, to request the HSS to expose an MBMS capability.", "403.The HSS checks subscription information, determines whether to allow the exposure of the MBMS capability to an OTT third party, and sends a subscription information response to the SCEF.", "404.The SCEF sends a second TMGI allocation request to a BM-SC, where the second TMGI allocation request is used to obtain exposed MBMS capability information from the BM-SC.", "405.The BM-SC determines the exposed MBMS capability information according to subscription information between the BM-SC and an operator, and sends the MBMS capability information to the SCEF.", "406.The SCEF forwards the MBMS capability information to the third-party server.", "For a specific implementation of step 401 to step 406, refer to step 202 to step 207 in the foregoing embodiment.", "407.The third-party server requests the SCEF to start an MBMS broadcast.", "The third-party server may specifically send a request message group message request to the SCEF, where the message may include the foregoing external group ID, SCS ID, port information of an SCS, and the like.", "408.The SCEF performs, according to the foregoing context, authorization check on the request sent by the third-party server.", "409.If it is determined, according to the authorization check, to start the MBMS broadcast, the SCEF queries the HSS whether the third-party server can use an MBMS channel.", "410.If the HSS determines that the third-party server can use an MBMS channel, the HSS sends a determining response to the SCEF.", "411.The SCEF starts the MBMS broadcast.", "412.The SCEF sends an MBMS enabling acknowledgment message to the third-party server.", "413.The third-party server detects that at least two UEs access same video content.", "For example, UE 1 sends an HTTP request message (including a URL) to the third-party server, and UE 2 also sends an HTTP request to the third-party server to request video content corresponding to the same URL.", "414.The third-party server notifies, to the at least two UEs by means of HTTP interaction between the third-party server and the UEs, a service portal link for transporting the video content.", "Specifically, the third-party server may send an HTTP redirection message to the UE 1 and the UE 2 separately.", "The HTTP redirection message includes a USD URL provided by the BM-SC, and redirects the UE to receive the video content by means of broadcast.", "Alternatively, step 414 is replaced with step 415.415.The BM-SC communicates with the UEs, to notify the UEs of the service portal link for transporting the video content, and that a UE-side MBMS client is ready.", "It may be understood that, in step 405, the USD URL may not be carried, and instead, a domain name address of the BM-SC is carried.", "In this way, the domain name address may be notified to the UEs by using the third-party server or the BM-SC, so that the UEs obtain the USD URL from the BM-SC according to the domain name address.", "That is, the service portal link for transporting the video content may be the domain name address of the BM-SC.", "416.The SCEF sends a bearer activation request message to the BM-SC.", "417.The BM-SC establishes an MBMS bearer.", "418.The BM-SC sends an MBMS bearer establishment success message to the SCEF.", "419.The BM-SC starts a broadcast, and obtains the video content from the third-party server.", "420.The UEs obtain the video content by using the MBMS bearer.", "For interaction between network elements in this embodiment, refer to FIG.", "5.Therefore, in this embodiment of the present invention, the third-party server requests in advance an MBMS capability exposure resource from a 3GPP network.", "The 3GPP network allows enabling of an MBMS video support capability.", "After detecting access requests of at least two UEs, the third-party server redirects the requests of the UEs to a broadcast reception mode, to receive video content.", "By means of the present application, the MBMS capability may be expanded to OTT video supporting.", "In this way, an OTT third party does not need to perform negotiation and testing with different operators and different terminals, and technical difficulty of the OTT in providing a video service is reduced.", "Therefore, problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network can be resolved.", "Based on the description of the foregoing embodiment, execution procedures for the third-party server, the BM-SC, and the HSS may be as follows: An embodiment of the present invention provides a video distribution method.", "As shown in FIG.", "6, the method includes the following steps.", "601.A third-party server sends a first request message to an SCEF, where the first request message includes an MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server.", "The MBMS capability negotiation parameter includes at least one of a transport mode indication of video content, a security feature indication for using an MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication.", "The transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode.", "The security feature indication is an enabled state or a disabled state.", "The content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported.", "The content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported.", "The QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported.", "The network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported.", "The network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state.", "The advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported.", "The advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "The first request message further includes port information of the third-party server and media encoding information of the third-party server.", "The port information of the third-party server is used for trusted channel data transmission between the third-party server and a BM-SC.", "The media encoding information of the third-party server includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "602.The third-party server receives a first response message sent by the SCEF, where the first response message includes exposed MBMS capability information obtained by the SCEF and a service portal link that is used for transporting video content and that is obtained from a broadcast multicast service center BM-SC.", "Before the sending, by a third-party server, a first request message to an SCEF, or after the receiving, by the third-party server, a first response message sent by the SCEF, the method further includes: receiving, by the third-party server, Hypertext Transfer Protocol HTTP request messages sent by at least two UEs, where the HTTP request message is used to request same video content.", "603.The third-party server sends, to UE, the service portal link for transporting the video content, and requests, according to the MBMS capability information, to start an MBMS broadcast to distribute the video content to the UE.", "After the sending, by the third-party server to user equipment UE, the service portal link for transporting the video content, the method further includes: sending, by the third-party server, the video content to the BM-SC, so that the UE obtains the video content by using an MBMS bearer.", "For a specific implementation of the third-party server, refer to the embodiment shown in FIG.", "1 to FIG.", "5.Details are not described herein again.", "This embodiment of the present invention provides a video distribution method.", "The third-party server sends a first request message to the service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server, receives a first response message sent by the SCEF, where the first response message includes exposed MBMS capability information obtained by the SCEF and a service portal link that is obtained by the broadcast multicast service center BM-SC and that is used for transporting video content, sends, to the UE, the video content for transporting the service portal link, and starts an MBMS broadcast according to the MBMS capability information, to distribute the video content to the UE.", "That is, when multiple UEs access the video content, the third-party server providing the video content may interact with an SCEF of a 3GPP and the BM-SC, and negotiates with the BM-SC to determine a to-be-exposed MBMS capability according to the MBMS capability negotiation parameter.", "The third-party server redirects requests of the UEs to a broadcast reception mode, to receive the video content, so as to expand the MBMS capability to OTT video supporting.", "In this way, an OTT third party does not need to perform negotiation and testing with different operators or different terminals, and technical difficulty of the OTT in providing a video service is reduced.", "Therefore, problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network can be resolved.", "An embodiment of the present invention provides a video distribution method.", "As shown in FIG.", "7, the method includes the following steps.", "701.A BM-SC receives a first request message sent by an SCEF, where the first request message is used to obtain MBMS capability information during video content distribution.", "The first request message includes an MBMS capability negotiation parameter for video distribution and that is requested by a third-party server, or the first request message includes second MBMS capability information that is to be exposed and that is determined by a home subscriber server HSS according to the MBMS capability negotiation parameter obtained from the third-party server.", "The first request message further includes port information and media encoding information of the third-party server.", "The port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC.", "The media encoding information of the third-party server includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "702.The BM-SC sends a first response message to the SCEF, where the first response message includes first MBMS capability information exposed by the BM-SC, so as to distribute video content to user equipment UE after the SCEF starts an MBMS broadcast according to the first MBMS capability information.", "The first response message includes port information of the BM-SC, a service portal link for transporting the video content, a charging rule, and media encoding information of the BM-SC.", "The port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server.", "The media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "Before the sending, by the BM-SC, a first response message to the SCEF, the method further includes: determining, by the BM-SC according to the MBMS capability negotiation parameter and subscription information between the BM-SC and an operator, the first MBMS capability information exposed by the BM-SC; or determining, by the BM-SC according to the second MBMS capability information that is to be exposed and that is determined by the HSS and subscription information between the BM-SC and the operator, the first MBMS capability information exposed by the BM-SC.", "After the sending, by the BM-SC, a first response message to the SCEF, the method further includes: sending, by the BM-SC to the UE, the service portal link for transporting the video content; and receiving, by the BM-SC according to the port information of the BM-SC, video content sent by the third-party server, and sending the video content to the UE.", "The MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "This embodiment of the present invention provides a video distribution method.", "The BM-SC receives a first request message sent by the SCEF, where the first request message is used to obtain multimedia broadcast multicast service MBMS capability information during video content distribution.", "The BM-SC sends a first response message to the SCEF, where the first response message includes the first MBMS capability information exposed by the BM-SC, so that the BM-SC and the SCEF start an MBMS broadcast according to the first MBMS capability information, to distribute video content to the user equipment UE.", "In this way, when multiple UEs access the video content, an OTT third party may interact with an SCEF of a 3GPP and the BM-SC, and negotiates with the BM-SC to determine a to-be-exposed MBMS capability according to the MBMS capability negotiation parameter, so that the third-party server redirects requests of the UEs to a broadcast reception mode, to receive the video content, so as to expand the MBMS capability to OTT video supporting.", "In this way, the OTT third party does not need to perform negotiation and testing with different operators or different terminals, and technical difficulty of the OTT in providing a video service is reduced.", "Therefore, problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network can be resolved.", "An embodiment of the present invention provides a video distribution method.", "As shown in FIG.", "8, the method includes the following steps.", "801.An HSS receives a first request message sent by an SCEF, where the first request message includes an MBMS capability negotiation parameter for video distribution and that is sent by an AS by using the SCEF, and/or an MBMS media capability exposure request indication sent by the SCEF, where the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability.", "802.The HSS determines, according to subscription information between the HSS and an operator, and the MBMS capability negotiation parameter and/or the MBMS media capability exposure request, whether to allow exposure of an MBMS capability.", "If the first request message includes the MBMS capability negotiation parameter, when the HSS determines to allow the exposure of the MBMS capability, the method further includes: determining, by the HSS, exposed MBMS capability information according to the subscription information and the MBMS capability negotiation parameter; and sending, by the HSS, a first response message to the SCEF, where the first response message includes the MBMS capability information.", "If the first request message includes the MBMS media capability exposure request indication, and the HSS determines to allow the exposure of the MBMS capability, the first response message includes an MBMS capability exposure request indication, to notify the SCEF that the exposure of the MBMS capability is allowed.", "The MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "This embodiment of the present invention provides a video distribution method.", "The HSS receives a first request message sent by the SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution and that is sent by a third-party server AS by using the SCEF, and/or an MBMS media capability exposure request indication sent by the SCEF, where the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability.", "The HSS determines, according to subscription information between the HSS and an operator, and the MBMS capability negotiation parameter and/or the MBMS media capability exposure request, whether to allow the exposure of the MBMS capability.", "In this way, when multiple UEs access the video content, an OTT third party may interact with an SCEF of a 3GPP and the HSS, and obtain, from the HSS, an indication for allowing the exposure of the capability, so that the third-party server negotiates with the BM-SC to determine a to-be-exposed MBMS capability according to the MBMS capability negotiation parameter, so that the third-party server redirects requests of the UEs to a broadcast reception mode, to receive the video content, so as to expand the MBMS capability to OTT video supporting.", "In this way, the OTT third party does not need to perform negotiation and testing with different operators or different terminals, and technical difficulty of the OTT in providing a video service is reduced.", "Therefore, problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network can be resolved.", "An embodiment of the present invention provides an SCEF 90.As shown in FIG.", "9, the SCEF 90 includes: a receiving unit 901, configured to receive a first request message sent by a third-party server, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; and a sending unit 902, configured to send a second request message to a home subscriber server HSS according to the first request message, to request the HSS to expose an MBMS capability.", "The sending unit 902 is further configured to send a third request message to a broadcast multicast service center BM-SC when the receiving unit receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request first MBMS capability information exposed by the BM-SC.", "The sending unit 902 is further configured to send the first MBMS capability information obtained from the BM-SC to the third-party server, to enable the-third party server to request, according to the first MBMS capability information, to start an MBMS broadcast, and distributes video content to user equipment UE.", "Optionally, the first request message further includes port information of the third-party server and media encoding information of the third-party server.", "The second request message includes the MBMS capability negotiation parameter and/or an MBMS media capability exposure request indication, and the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability.", "If the second request message includes the MBMS capability negotiation parameter, the second response message includes second MBMS capability information that is to be exposed and that is determined by the HSS according to subscription information between the HSS and an operator and the MBMS capability negotiation parameter.", "If the second request message includes the MBMS media capability exposure request indication, the second response message includes an MBMS capability exposure request indication, and the MBMS capability exposure request indication is used to request the first MBMS capability information exposed and determined by the BM-SC.", "The third request message includes the port information of the third-party server and the media encoding information of the third-party server.", "If the second response message includes the second MBMS capability information, the third request message further includes the second MBMS capability information.", "If the second response message does not include the second MBMS capability information, the third request message further includes the MBMS capability negotiation parameter.", "Optionally, the receiving unit 901 is further configured to: receive a third response message sent by the BM-SC, where the third response message includes the first MBMS capability information, a service portal link for transporting the video content, port information of the BM-SC, a charging rule, and media encoding information of the BM-SC.", "Optionally, the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "The port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC.", "The port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server.", "The media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "This embodiment of the present invention provides an SCEF.", "The SCEF receives a first request message sent by the third-party server, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server, and sends a second request message to the home subscriber server HSS according to the first request message, to request the HSS to expose an MBMS capability.", "The SCEF sends a third request message to the broadcast multicast service center BM-SC after the SCEF receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request to obtain MBMS capability information exposed by the BM-SC.", "The SCEF sends the exposed MBMS capability information obtained from the BM-SC to the third-party server, so that the third-party server starts an MBMS broadcast according to the exposed MBMS capability information and distributes video content to the user equipment UE.", "That is, when multiple UEs access the video content, the third-party server providing the video content may interact with an SCEF of a 3GPP and the BM-SC, and negotiates with the BM-SC to determine a to-be-exposed MBMS capability according to the MBMS capability negotiation parameter.", "The third-party server redirects requests of the UEs to a broadcast reception mode, to receive the video content, so as to expand the MBMS capability to OTT video supporting.", "In this way, an OTT third party does not need to perform negotiation and testing with different operators or different terminals, and technical difficulty of the OTT in providing a video service is reduced.", "Therefore, problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network can be resolved.", "An embodiment of the present invention provides a third-party server 10.As shown in FIG.", "10, the third-party server 10 includes: a sending unit 101, configured to send a first request message to a service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server; a receiving unit 102, configured to receive a first response message sent by the SCEF, where the first response message includes exposed MBMS capability information obtained by the SCEF and a service portal link that is used for transporting video content and that is obtained from a broadcast multicast service center BM-SC, where the sending unit 101 is further configured to send, to the UE, the service portal link for transporting the video content; and a processing unit 103, configured to request, according to the MBMS capability information, to start an MBMS broadcast to distribute the video content to the UE.", "Optionally, the MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "The first request message further includes port information of the third-party server and media encoding information of the third-party server.", "The first response message further includes port information of the BM-SC, media encoding information of the BM-SC, and a charging rule that are obtained by the SCEF.", "The port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "Optionally, the receiving unit 102 is further configured to: before the third-party server sends the first request message to the SCEF, or after the third-party server receives the first response message sent by the SCEF, receive Hypertext Transfer Protocol HTTP request messages sent by at least two UEs, where the HTTP request message is used to request same video content.", "Optionally, the sending unit 101 is further configured to: after sending, to the user equipment UE, the service portal link for transporting the video content, send the video content to the BM-SC or the SCEF.", "This embodiment of the present invention provides a third-party server.", "The third-party server sends a first request message to the service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server, receives a first response message sent by the SCEF, where the first response message includes exposed MBMS capability information obtained by the SCEF and a service portal link that is obtained by the broadcast multicast service center BM-SC and that is used for transporting video content, sends, to the UE, the video content for transporting the service portal link, and starts an MBMS broadcast according to the MBMS capability information, to distribute the video content to the UE.", "That is, when multiple UEs access the video content, the third-party server providing the video content may interact with an SCEF of a 3GPP and the BM-SC, and negotiates with the BM-SC to determine a to-be-exposed MBMS capability according to the MBMS capability negotiation parameter.", "The third-party server redirects requests of the UEs to a broadcast reception mode, to receive the video content, so as to expand the MBMS capability to OTT video supporting.", "In this way, an OTT third party does not need to perform negotiation and testing with different operators or different terminals, and technical difficulty of the OTT in providing a video service is reduced.", "Therefore, problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network can be resolved.", "An embodiment of the present invention provides a BM-SC 11.As shown in FIG.", "11, the BM-SC 11 includes: a receiving unit 111, configured to receive a first request message sent by a service capability exposure function SCEF, where the first request message is used to obtain multimedia broadcast multicast service MBMS capability information during video content distribution; and a sending unit 112, configured to send a first response message to the SCEF, where the first response message includes first MBMS capability information exposed by the BM-SC, so as to distribute video content to user equipment UE after the SCEF starts an MBMS broadcast according to the first MBMS capability information.", "Optionally, the first request message includes an MBMS capability negotiation parameter for video distribution and that is requested by a third-party server, or the first request message includes second MBMS capability information that is to be exposed and that is determined by a home subscriber server HSS according to the MBMS capability negotiation parameter obtained from the third-party server.", "The BM-SC further includes: a processing unit 113, configured to determine, according to the MBMS capability negotiation parameter and subscription information between the BM-SC and an operator, the first MBMS capability information exposed by the BM-SC; or the processing unit 113 is configured to determine, according to the second MBMS capability information that is to be exposed and that is determined by the HSS and subscription information between the BM-SC and the operator, the first MBMS capability information exposed by the BM-SC.", "Optionally, the first request message further includes port information of the third-party server and media encoding information of the third-party server.", "The first response message includes port information of the BM-SC, a service portal link for transporting the video content, a charging rule, and media encoding information of the BM-SC.", "The port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC.", "The port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server.", "The media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "The MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "Optionally, the sending unit 112 is further configured to send, to the UE, the service portal link for transporting the video content.", "The receiving unit 111 is further configured to receive, according to the port information of the BM-SC, video content sent by the third-party server.", "The sending unit 112 is further configured to send the video content to the UE.", "This embodiment of the present invention provides a BM-SC.", "The BM-SC receives a first request message sent by the SCEF, where the first request message is used to obtain multimedia broadcast multicast service MBMS capability information during video content distribution.", "The BM-SC sends a first response message to the SCEF, where the first response message includes the MBMS capability information exposed by the BM-SC, so that the BM-SC and the SCEF start an MBMS broadcast according to the MBMS capability information, to distribute video content to the user equipment UE.", "In this way, when multiple UEs access the video content, the third-party server providing the video content may interact with an SCEF of a 3GPP and the BM-SC, and negotiates with the BM-SC to determine a to-be-exposed MBMS capability according to the MBMS capability negotiation parameter, so that the third-party server redirects requests of the UEs to a broadcast reception mode, to receive the video content, so as to expand the MBMS capability to OTT video supporting.", "In this way, an OTT third party does not need to perform negotiation and testing with different operators or different terminals, and technical difficulty of the OTT in providing a video service is reduced.", "Therefore, problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network can be resolved.", "An embodiment of the present invention provides an HSS 12.As shown in FIG.", "12, the HSS 12 includes: a receiving unit 121, configured to receive a first request message sent by a service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution and that is sent by a third-party server AS by using the SCEF, and/or an MBMS media capability exposure request indication sent by the SCEF, where the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability; and a processing unit 122, configured to determine, according to subscription information between the HSS and an operator, and the MBMS capability negotiation parameter and/or the MBMS media capability exposure request, whether to allow the exposure of the MBMS capability.", "Optionally, if the first request message includes the MBMS capability negotiation parameter, the processing unit is further configured to determine exposed MBMS capability information according to the subscription information and the MBMS capability negotiation parameter.", "The HSS further includes a sending unit 123, configured to send a first response message to the SCEF, where the first response message includes the MBMS capability information.", "If the first request message includes the MBMS media capability exposure request indication, and the HSS determines to allow the exposure of the MBMS capability, the first response message includes an MBMS capability exposure request indication, to notify the SCEF that the exposure of the MBMS capability is allowed.", "Optionally, the MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "This embodiment of the present invention provides an HSS.", "The HSS receives a first request message sent by the service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution and that is sent by a third-party server AS by using the SCEF, and/or an MBMS media capability exposure request indication sent by the SCEF, where the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability.", "The HSS determines, according to subscription information between the HSS and an operator, and the MBMS capability negotiation parameter and/or the MBMS media capability exposure request, whether to allow the exposure of the MBMS capability.", "In this way, when multiple UEs access the video content, an OTT third party may interact with an SCEF of a 3GPP and the HSS, and obtain, from the HSS, an indication for allowing the exposure of the capability, so that the third-party server negotiates with the BM-SC to determine a to-be-exposed MBMS capability according to the MBMS capability negotiation parameter, so that the third-party server redirects requests of the UEs to a broadcast reception mode, to receive the video content, so as to expand the MBMS capability to OTT video supporting.", "In this way, the OTT third party does not need to perform negotiation and testing with different operators or different terminals, and technical difficulty of the OTT in providing a video service is reduced.", "Therefore, problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network can be resolved.", "An embodiment of the present invention provides an SCEF 13.As shown in FIG.", "13, the SCEF 13 includes a receiver 131, a transmitter 132, a memory 133, and a bus 134.The memory 133 is configured to store data and an instruction.", "The receiver 131 executes the instruction and is configured to receive a first request message sent by a third-party server, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server.", "The transmitter 132 executes the instruction and is configured to send a second request message to a home subscriber server HSS according to the first request message, to request the HSS to expose an MBMS capability.", "The transmitter 132 executes the instruction and is further configured to send a third request message to a broadcast multicast service center BM-SC when the receiver receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request first MBMS capability information exposed by the BM-SC.", "The transmitter 132 executes the instruction and is further configured to send the first MBMS capability information obtained from the BM-SC to the third-party server, to enable the-third party server to request, according to the first MBMS capability information, to start an MBMS broadcast, and distributes video content to user equipment UE.", "In this embodiment of the present invention, optionally, the first request message further includes port information of the third-party server and media encoding information of the third-party server.", "The second request message includes the MBMS capability negotiation parameter and/or an MBMS media capability exposure request indication, and the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability.", "If the second request message includes the MBMS capability negotiation parameter, the second response message includes second MBMS capability information that is to be exposed and that is determined by the HSS according to subscription information between the HSS and an operator and the MBMS capability negotiation parameter.", "If the second request message includes the MBMS media capability exposure request indication, the second response message includes an MBMS capability exposure request indication, and the MBMS capability exposure request indication is used to request the first MBMS capability information exposed and determined by the BM-SC.", "The third request message includes the port information of the third-party server and the media encoding information of the third-party server.", "If the second response message includes the second MBMS capability information, the third request message further includes the second MBMS capability information.", "If the second response message does not include the second MBMS capability information, the third request message further includes the MBMS capability negotiation parameter.", "In this embodiment of the present invention, optionally, the receiver 131 executes the instruction and is further configured to receive a third response message sent by the BM-SC, where the third response message includes the first MBMS capability information, a service portal link for transporting the video content, port information of the BM-SC, a charging rule, and media encoding information of the BM-SC.", "In this embodiment, optionally, the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "The port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC.", "The port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server.", "The media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "This embodiment of the present invention provides an SCEF.", "The SCEF receives a first request message sent by the third-party server, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server, and sends a second request message to the home subscriber server HSS according to the first request message, to request the HSS to expose an MBMS capability.", "The SCEF sends a third request message to the broadcast multicast service center BM-SC after the SCEF receives a second response message returned by the HSS when the HSS determines to allow the exposure of the MBMS capability, to request to obtain MBMS capability information exposed by the BM-SC.", "The SCEF sends the exposed MBMS capability information obtained from the BM-SC to the third-party server, so that the third-party server starts an MBMS broadcast according to the exposed MBMS capability information and distributes video content to the user equipment UE.", "That is, when multiple UEs access the video content, the third-party server providing the video content may interact with an SCEF of a 3GPP and the BM-SC, and negotiates with the BM-SC to determine a to-be-exposed MBMS capability according to the MBMS capability negotiation parameter.", "The third-party server redirects requests of the UEs to a broadcast reception mode, to receive the video content, so as to expand the MBMS capability to OTT video supporting.", "In this way, an OTT third party does not need to perform negotiation and testing with different operators or different terminals, and technical difficulty of the OTT in providing a video service is reduced.", "Therefore, problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network can be resolved.", "An embodiment of the present invention provides a third-party server 14.As shown in FIG.", "14, the third-party server 14 includes: a receiver 141, a transmitter 142, a processor 143, a memory 144, and a bus 145.The memory 144 is configured to store an instruction and data.", "The transmitter 142 executes the instruction and is configured to send a first request message to a service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server.", "The receiver 141 executes the instruction and is configured to receive a first response message sent by the SCEF, where the first response message includes exposed MBMS capability information obtained by the SCEF and a service portal link that is used for transporting video content and that is obtained from a broadcast multicast service center BM-SC.", "The transmitter 142 executes the instruction and is further configured to send, to UE, the service portal link for transporting the video content.", "The processor 143 executes the instruction and is configured to request, according to the MBMS capability information, to start an MBMS broadcast to distribute the video content to the UE.", "In this embodiment of the present invention, optionally, the MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "The first request message further includes port information of the third-party server and media encoding information of the third-party server.", "The first response message further includes port information of the BM-SC, media encoding information of the BM-SC, and a charging rule that are obtained by the SCEF.", "The port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC; the port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server; and the media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "In this embodiment of the present invention, optionally, the receiver 141 executes the instruction and is further configured to: before the transmitter 142 sends the first request message to the SCEF, or after the receiver 141 receives the first response message sent by the SCEF, receive Hypertext Transfer Protocol HTTP request messages sent by at least two UEs, where the HTTP request message is used to request same video content.", "In this embodiment of the present invention, optionally, the transmitter 142 executes the instruction and is further configured to: after sending, to the user equipment UE, the service portal link for transporting the video content, send the video content to the BM-SC or the SCEF.", "This embodiment of the present invention provides a third-party server.", "The third-party server sends a first request message to the service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution, the MBMS capability negotiation parameter being requested by the third-party server, receives a first response message sent by the SCEF, where the first response message includes exposed MBMS capability information obtained by the SCEF and a service portal link that is obtained by the broadcast multicast service center BM-SC and that is used for transporting video content, sends, to the UE, the video content for transporting the service portal link, and starts an MBMS broadcast according to the MBMS capability information, to distribute the video content to the UE.", "That is, when multiple UEs access the video content, the third-party server providing the video content may interact with an SCEF of a 3GPP and the BM-SC, and negotiates with the BM-SC to determine a to-be-exposed MBMS capability according to the MBMS capability negotiation parameter.", "The third-party server redirects requests of the UEs to a broadcast reception mode, to receive the video content, so as to expand the MBMS capability to OTT video supporting.", "In this way, an OTT third party does not need to perform negotiation and testing with different operators or different terminals, and technical difficulty of the OTT in providing a video service is reduced.", "Therefore, problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network can be resolved.", "An embodiment of the present invention provides a BM-SC 15.As shown in FIG.", "15, the BM-SC 15 includes: a receiver 151, a transmitter 152, a memory 153, a bus 154, and a processor 155.The memory 153 is configured to store an instruction and data.", "The receiver 151 executes the instruction and is configured to receive a first request message sent by a service capability exposure function SCEF, where the first request message is used to obtain multimedia broadcast multicast service MBMS capability information during video content distribution.", "The transmitter 152 executes the instruction and is configured to send a first response message to the SCEF, where the first response message includes first MBMS capability information exposed by the BM-SC, so as to distribute video content to user equipment UE after the SCEF starts an MBMS broadcast according to the first MBMS capability information.", "In this embodiment of the present invention, optionally, the first request message includes an MBMS capability negotiation parameter for video distribution and that is requested by a third-party server, or the first request message includes second MBMS capability information that is to be exposed and that is determined by a home subscriber server HSS according to the MBMS capability negotiation parameter obtained from the third-party server.", "The processor 155 executes the instruction and is configured to: determine, according to the MBMS capability negotiation parameter and subscription information between the BM-SC and an operator, the first MBMS capability information exposed by the BM-SC; or determine, according to the second MBMS capability information that is to be exposed and that is determined by the HSS and subscription information between the BM-SC and an operator, the first MBMS capability information exposed by the BM-SC.", "In this embodiment of the present invention, optionally, the first request message further includes port information of the third-party server and media encoding information of the third-party server.", "The first response message includes port information of the BM-SC, a service portal link for transporting the video content, a charging rule, and media encoding information of the BM-SC.", "The port information of the third-party server is used for trusted channel data transmission between the third-party server and the BM-SC.", "The port information of the BM-SC is used for trusted channel data transmission between the BM-SC and the third-party server.", "The media encoding information includes at least one of video encoding information, audio encoding information, text encoding information, or picture encoding information.", "In this embodiment of the present invention, optionally, the MBMS capability negotiation parameter, the first MBMS capability information, and the second MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "This embodiment of the present invention provides a BM-SC.", "The BM-SC receives a first request message sent by the SCEF, where the first request message is used to obtain multimedia broadcast multicast service MBMS capability information during video content distribution.", "The BM-SC sends a first response message to the SCEF, where the first response message includes the MBMS capability information exposed by the BM-SC, so that after starting an MBMS broadcast according to the MBMS capability information, the SCEF distributes video content to the user equipment UE.", "In this way, when multiple UEs access the video content, the third-party server providing the video content may interact with an SCEF of a 3GPP and the BM-SC, and negotiates with the BM-SC to determine a to-be-exposed MBMS capability according to the MBMS capability negotiation parameter, so that the third-party server redirects requests of the UEs to a broadcast reception mode, to receive the video content, so as to expand the MBMS capability to OTT video supporting.", "In this way, an OTT third party does not need to perform negotiation and testing with different operators or different terminals, and technical difficulty of the OTT in providing a video service is reduced.", "Therefore, problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network can be resolved.", "An embodiment of the present invention provides an HSS 16.As shown in FIG.", "16, the HSS 16 includes a receiver 161, a transmitter 162, a processor 163, a memory 164, and a bus 165.The memory 164 is configured to store an instruction and data.", "The receiver 161 executes the instruction and is configured to receive a first request message sent by a service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution and that is sent by a third-party server AS by using the SCEF, and/or an MBMS media capability exposure request indication sent by the SCEF, where the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability.", "The transmitter 162 executes the instruction and is configured to determine, according to subscription information between the HSS 16 and an operator, and the MBMS capability negotiation parameter and/or the MBMS media capability exposure request, whether to allow the exposure of the MBMS capability.", "In this embodiment of the present invention, optionally, if the first request message includes the MBMS capability negotiation parameter, when the processor 163 is configured to determine to allow the exposure of the MBMS capability, the processor 163 is further configured to determine exposed MBMS capability information according to the subscription information and the MBMS capability negotiation parameter.", "The transmitter is further configured to send a first response message to the SCEF, where the first response message includes the MBMS capability information.", "If the first request message includes the MBMS media capability exposure request indication, and the HSS determines to allow the exposure of the MBMS capability, the first response message includes an MBMS capability exposure request indication, to notify the SCEF that the exposure of the MBMS capability is allowed.", "In this embodiment of the present invention, optionally, the MBMS capability negotiation parameter and the MBMS capability information separately include at least one of a transport mode indication of the video content, a security feature indication for using the MBMS, a content transcoding capability support indication, a content caching indication, a quality of experience QoE reporting indication, a network information reporting indication, an advertisement purchasing information indication, or an advertisement insertion capability indication, where the transport mode indication is a broadcast mode, or a broadcast/unicast hybrid mode, or a dynamic broadcast/unicast mode; the security feature indication is an enabled state or a disabled state; the content transcoding capability support indication is an indication showing that transcoding is supported or an indication showing that transcoding is not supported; the content caching indication is an indication showing that content caching is supported or an indication showing that content caching is not supported; the QoE reporting indication is an indication showing that QoE is to be reported or an indication showing that QoE is not to be reported; the network information reporting indication is an indication showing that network information is to be reported or an indication showing that network information is not to be reported, the network information includes at least one of a UE identifier, a serving cell identifier, or a network congestion state; the advertisement purchasing information indication is an indication showing that an event of purchasing advertisement content by a user is to be reported or an indication showing that an event of purchasing advertisement content by a user is not to be reported; and the advertisement insertion capability indication is an indication showing that insertion of an advertisement is supported or an indication showing that insertion of an advertisement is not supported.", "This embodiment of the present invention provides an HSS.", "The HSS receives a first request message sent by the service capability exposure function SCEF, where the first request message includes a multimedia broadcast multicast service MBMS capability negotiation parameter for video distribution and that is sent by a third-party server AS by using the SCEF, and/or an MBMS media capability exposure request indication sent by the SCEF, where the MBMS media capability exposure request indication is used to request the HSS to expose an MBMS pipe capability.", "The HSS determines, according to subscription information between the HSS and an operator, and the MBMS capability negotiation parameter and/or the MBMS media capability exposure request, whether to allow the exposure of the MBMS capability.", "In this way, when multiple UEs access the video content, an OTT third party may interact with an SCEF of a 3GPP and the HSS, and obtain, from the HSS, an indication for allowing the exposure of the capability, so that the third-party server negotiates with the BM-SC to determine a to-be-exposed MBMS capability according to the MBMS capability negotiation parameter, so that the third-party server redirects requests of the UEs to a broadcast reception mode, to receive the video content, so as to expand the MBMS capability to OTT video supporting.", "In this way, the OTT third party does not need to perform negotiation and testing with different operators or different terminals, and technical difficulty of the OTT in providing a video service is reduced.", "Therefore, problems of heavy workload and complex management when an operator exposes an MBMS media capability to an OTT third party, and problems of heavy IOT workload and heavy video distribution and management load when the OTT third party distributes videos by using a mobile network can be resolved.", "In the several embodiments provided in the present application, it should be understood that the disclosed device and method may be implemented in other manners.", "For example, the described device embodiment is merely exemplary.", "For example, the unit division is merely logical function division and may be other division in actual implementation.", "For example, a plurality of units or components may be combined or integrated into another system, or some features may be ignored or not performed.", "In addition, the displayed or discussed mutual couplings or direct couplings or communication connections may be implemented by using some interfaces.", "The indirect couplings or communication connections between the apparatuses or units may be implemented in electronic, mechanical, or other forms.", "In addition, functional units in the devices and systems in the embodiments of the present invention may be integrated into one processing unit, or each of the units may exist alone physically, or two or more units are integrated into one unit.", "The units may be implemented in a form of hardware, or may be implemented in a form of hardware in addition to a software functional unit.", "All or some of the steps of the method embodiments may be implemented by a program instructing relevant hardware.", "The program may be stored in a computer-readable storage medium.", "When the program runs, the steps of the method embodiments are performed.", "The foregoing storage medium includes: any medium that can store program code, such as a USB flash drive, a removable hard disk, a read-only memory (ROM for short), a random access memory (RAM for short), a magnetic disk, or an optical disc.", "The foregoing descriptions are merely specific implementations of the present application, but are not intended to limit the protection scope of the present application.", "Any variation or replacement readily figured out by a person skilled in the art within the technical scope disclosed in the present application shall fall within the protection scope of the present application.", "Therefore, the protection scope of the present application shall be subject to the protection scope of the claims." ] ]
Patent_15876142
[ [ "Collapsible, Folding Mattress Support with a Headboard and a Footboard that Fold Out", "A foldable mattress support includes a headboard, a central hinge portion and first and second portions of a bedboard frame.", "The first and second portions are pivotally attached to the central hinge.", "A longer first strut is pivotally attached at a first location to a side bar of the first portion and at a third location to a post of the headboard.", "A shorter second strut is pivotally attached at a second location to the side bar and at a fourth location to the post.", "The second location is closer to the head end of the first portion than is the first location, and the fourth location is closer to the top of the post than is the third location.", "The struts rotate the headboard from an unfolded state that is perpendicular to the first portion down to being parallel and adjacent to the first portion in a collapsed state." ], [ "1-17.", "(canceled) 18.A foldable mattress support comprising: a bedboard frame with a first portion and a second portion; a central hinge portion that is pivotally attached to the first portion and the second portion; a headboard frame; and means for rotating the headboard frame from a collapsed state that is parallel and adjacent to the first portion to an unfolded state that is perpendicular to the first portion without pivoting the headboard frame about any axis whose position is fixed with respect to the first portion.", "19.The foldable mattress support of claim 18, wherein the first portion has a head end and a center end, wherein the central hinge portion is pivotally attached to the center end of the first portion, wherein the means comprises a first bracing strut that is pivotally attached at a first location to the first portion and a second bracing strut that is pivotally attached at a second location to the first portion, wherein the second location is closer to the head end than is the first location, and wherein the first bracing strut is longer than the second bracing strut.", "20.The foldable mattress support of claim 18, wherein the means is pivotally attached to the first portion both at a first location and at a second location, wherein the means is pivotally attached to the headboard frame both at a third location and at a fourth location, and wherein the first location is closer to the second location than the third location is to the fourth location.", "21.The foldable mattress support of claim 18, wherein the headboard frame has a top end and a foot end, wherein the means comprises a first bracing strut that is pivotally attached to the headboard frame at a third location and a second bracing strut that is pivotally attached to the headboard frame at a fourth location, wherein the fourth location is closer to the top end than is the third location, and wherein the first bracing strut is longer than the second bracing strut.", "22.The foldable mattress support of claim 18, further comprising: a footboard frame pivotally attached to a longer bracing strut and a shorter bracing strut, wherein the longer bracing strut and the shorter bracing strut are pivotally attached to the second portion of the bedboard frame.", "23.The foldable mattress support of claim 18, wherein the first portion has a head end and a center end, wherein the central hinge portion is pivotally attached to the center end of the first portion, wherein the first portion has a length from the head end to the center end, wherein the headboard frame has a post with a top end and a foot end, and wherein the post is more than three quarters as long as the length of the first portion.", "24.The foldable mattress support of claim 18, wherein the first portion has a head end and a center end, wherein the central hinge portion is pivotally attached to the center end of the first portion, wherein the headboard frame has a post with a top end and a foot end, and wherein when the foldable mattress support is in the unfolded state the head end of the first portion contacts the post of the headboard frame at a location that is closer to the foot end than the top end of the post.", "25.The foldable mattress support of claim 18, wherein in the collapsed state the first portion of the bedboard frame is parallel to the second portion of the bedboard frame, and the headboard frame is parallel to the first portion of the bedboard frame, wherein the foldable mattress support is disposed in a packing box, and wherein the headboard frame is disposed between the first portion of the bedboard frame and the second portion of the bedboard frame.", "26.The foldable mattress support of claim 18, further comprising: a footboard frame, wherein in the collapsed state the first portion of the bedboard frame is parallel to the headboard frame, and the headboard frame is parallel to the footboard frame, and wherein in the collapsed state both the headboard frame and the footboard frame are disposed between the first portion of the bedboard frame and the second portion of the bedboard frame.", "27.The foldable mattress support of claim 18, further comprising: a footboard frame, wherein in the collapsed state the foldable mattress support is disposed in a packing box, and wherein the packing box has a thickness that is only slightly greater than a sum of widths of the first portion of the bedboard frame, the second portion of the bedboard frame, the headboard frame and the footboard frame.", "28.A bed frame comprising: a bedboard frame adapted to support a mattress; a footboard frame; a headboard frame; and means for rotating the headboard frame from a collapsed state that is parallel and adjacent to the bedboard frame to an unfolded state that is perpendicular to the bedboard frame without pivoting the headboard frame about any axis whose position is fixed with respect to the bedboard frame.", "29.The bed frame of claim 28, wherein the means includes two metal struts of different lengths.", "30.The bed frame of claim 28, wherein the means includes a first bracing strut that is pivotally attached at a first end to the bedboard frame and at a third end to the headboard frame, and wherein the means further includes a second bracing strut that is pivotally attached at a second end to the bedboard frame and at a fourth end to the headboard frame, and wherein the first bracing strut is longer than the second bracing strut.", "31.The bed frame of claim 30, wherein the first end of the first bracing strut is attached at a first location to a bar of the bedboard frame, wherein the second end of the second bracing strut is attached at a second location to the bar of the bedboard frame, and wherein the first location and the second location are located on opposite sides of the bar.", "32.The bed frame of claim 30, wherein the first end is attached to the bedboard frame at a first location, the second end is attached to the bedboard frame at a second location, the third end is attached to the headboard frame at a third location, and the fourth end is attached to the headboard frame at a fourth location, and wherein the first location is closer to the second location than the third location is to the fourth location.", "33.The bed frame of claim 32, wherein the fourth location is closer to a top end of the headboard frame than is the third location.", "34.The bed frame of claim 28, wherein the bedboard frame has a head end, wherein the headboard frame has a post with a top end and a foot end, and wherein when the bed frame is in the unfolded state the head end of the bedboard frame contacts the post of the headboard frame at a location that is closer to the foot end than the top end of the post.", "35.The bed frame of claim 28, further comprising: a packing box, wherein the bedboard frame has a first portion and a second portion, wherein in the collapsed state the first portion is parallel to the second portion, and the headboard frame is parallel to the first portion, wherein the bed frame is disposed in the packing box, and wherein the headboard frame is disposed between the first portion and the second portion.", "36.The bed frame of claim 28, further comprising: a footboard frame, wherein the bedboard frame has a first portion and a second portion, wherein in the collapsed state the first portion is parallel to the headboard frame, and the headboard frame is parallel to the footboard frame, and wherein in the collapsed state both the headboard frame and the footboard frame are disposed between the first portion and the second portion.", "37.The bed frame of claim 28, further comprising: a footboard frame, wherein the bedboard frame has a first portion and a second portion, wherein in the collapsed state the bed frame is disposed in a packing box, and wherein the packing box has a thickness that is only slightly greater than a sum of widths of the first portion of the bedboard frame, the second portion of the bedboard frame, the headboard frame and the footboard frame." ], [ "<SOH> BACKGROUND INFORMATION <EOH>Conventional beds generally include a mattress resting on a box springs that is supported by a bed frame.", "Box springs are generally designed to have the outward appearance of a mattress, being covered by quilted fabric and cushioning, for example.", "Typically, box springs have a wooden rectangular frame supporting an array of springs to provide firm support for the mattress.", "A box springs is usually constructed in one piece having the same dimensions as the mattress it supports.", "A conventional box springs, due to its stiff wooden frame, is often heavy and awkward to handle.", "The dimensions of a conventional box spring make it impractical for a consumer to transport the box springs home from a mass-market retail store.", "For example, the typical box springs does not fit in the trunk of a car.", "Moving such a box-springs into apartment elevators and around corners into bedrooms is often difficult and exposes the box springs and doorways to potential damage.", "In addition, the dimensions of a conventional box springs take up valuable retail floor space which discourages mass-market stores from offering box springs to their retail customers.", "Attempts have been made to develop folding mattress supports in the form of collapsible box springs or collapsible bed frames upon which a mattress can be directly placed.", "For example, FIG.", "1 (prior art) shows a foldable bedding foundation 10 as disclosed in U.S. Pat.", "No.", "7,376,988.Bedding foundation 10 has wire struts 11 that pivotally secure an upper wire grid 12 to wooden rails of the base 13 .", "Wire braces 14 slide along the wire struts 11 and hold the bedding foundation 10 in an erected position when the foundation is unfolded.", "The two portions of the upper wire grid 12 are connected to each other by an upper hinge 15 .", "Upper hinge 15 is a small piece of plastic that clips onto the border wires of each of the two portions of the upper wire grid 12 .", "The two portions of the base 13 are connected to each other by a lower hinge 16 , which is a piece of wire.", "Upper hinge 15 and lower hinge 16 are not attached to each other.", "The wire braces that slide along wire struts and the upper wire grids that are clipped together with a plastic hinge render bedding foundation 10 less sturdy than a conventional box springs.", "Moreover, bedding foundation 10 lacks a headboard and a footboard, so most consumers would prefer to place foundation 10 on another bed foundation whose aesthetic appearance more resembles a bed.", "A support for a mattress is sought that provides all of the support, comfort and aesthetic qualities of a conventional box springs supported by a bed foundation but yet that reduces the transportation and storage space requirements of a conventional bed and box springs combination.", "Moreover, the novel mattress support should be less flimsy than a foldable bed foundation that employs wire braces, wire struts, wire hinges and wire grids that are clipped together." ], [ "<SOH> SUMMARY <EOH>A foldable mattress support includes a headboard frame, a central hinge portion, first and second portions of a bedboard frame and bracing struts.", "The headboard frame is parallel to the first portion when the foldable mattress support is completely collapsed and perpendicular to the first portion when the foldable mattress support is completely unfolded.", "The first portion and the second portion are pivotally attached to the central hinge portion.", "A first bracing strut is pivotally attached at a first location to a side bar of the first portion, and a second bracing strut is pivotally attached at a second location to the side bar.", "The first location and the second location are located on opposite sides of the side bar.", "The first bracing strut is longer than the second bracing strut.", "The second location is closer to the head end of the first portion than is the first location.", "The first bracing strut is pivotally attached at a third location to a post of the headboard frame, and the second bracing strut is pivotally attached at a fourth location to the post.", "The fourth location is closer to the top end of the post than is the third location.", "The first location is closer to the second location than the third location is to the fourth location.", "The bracing struts are used to rotate the headboard frame from a collapsed state that is parallel and adjacent to the first portion to an unfolded state that is perpendicular to the first portion without pivoting the headboard frame about any axis whose position is fixed with respect to the first portion.", "A footboard frame that is analogously attached to bracing struts is rotated from a collapsed state that is parallel and adjacent to the second portion to an unfolded state that is perpendicular to the second portion.", "When the mattress support is completely collapsed, the first portion is substantially parallel to the second portion with the headboard frame and footboard frame sandwiched between the two portions of bedboard frame.", "The posts of the headboard frame and the footboard frame are parallel to the legs of the central hinge portion when the foldable mattress support is completely unfolded.", "The bracing struts permit the headboard frame to be completely folded under the first portion of the bedboard frame without extending out beyond the head end despite the fact that the posts of the headboard frame are nearly as long as the side bars of first portion.", "For example, the posts of the headboard frame can be more than three quarters as long as the side bars of the first portion.", "A method of making and packaging a foldable mattress support includes folding down a headboard and a footboard and then folding a bedboard frame in half.", "A headboard frame is folded parallel to a first portion of the bedboard frame.", "The headboard is folded from a perpendicular orientation down and around the head end of the bedboard frame to being parallel and adjacent to the first portion.", "The folding is performed using bracing struts.", "A first bracing strut is pivotally attached at a first location to the first portion and at a third location to the headboard frame.", "A second bracing strut is pivotally attached at a second location to the first portion and at a fourth location to the headboard frame.", "The first bracing strut is longer than the second bracing strut.", "The first location is closer to the second location than the third location is to the fourth location.", "The footboard frame is also folded parallel and adjacent to the second portion.", "The first portion of the bedboard frame is then folded into the second portion of the bedboard frame.", "The first and second portions are pivotally attached to a central hinge portion.", "The first portion is pivotally attached at its center end to the central hinge portion.", "The second location is closer to the head end of the first portion than is the first location.", "The folded bedboard frame with the headboard and footboard sandwiched between the first and second portions is then inserted into a packing box.", "Instructions are also inserted into the packing box that instruct the user of the foldable mattress support to unfold the folded bedboard frame such that the headboard frame is perpendicular to the first portion.", "Further details and embodiments are described in the detailed description below.", "This summary does not purport to define the invention.", "The invention is defined by the claims." ], [ "CROSS REFERENCE TO RELATED APPLICATION This application is a continuation of, and claims priority under 35 U.S.C.", "§ 120 from, nonprovisional U.S. patent application Ser.", "No.", "14/929,202 entitled “A Collapsible, Folding Mattress Support with a Headboard and a Footboard that Fold Out,” filed on Oct. 30, 2015, the subject matter of which is incorporated herein by reference.", "TECHNICAL FIELD The present invention relates to bedding products, and in particular to a collapsible, folding mattress support with a headboard and a footboard that fold out from under a bedboard frame.", "BACKGROUND INFORMATION Conventional beds generally include a mattress resting on a box springs that is supported by a bed frame.", "Box springs are generally designed to have the outward appearance of a mattress, being covered by quilted fabric and cushioning, for example.", "Typically, box springs have a wooden rectangular frame supporting an array of springs to provide firm support for the mattress.", "A box springs is usually constructed in one piece having the same dimensions as the mattress it supports.", "A conventional box springs, due to its stiff wooden frame, is often heavy and awkward to handle.", "The dimensions of a conventional box spring make it impractical for a consumer to transport the box springs home from a mass-market retail store.", "For example, the typical box springs does not fit in the trunk of a car.", "Moving such a box-springs into apartment elevators and around corners into bedrooms is often difficult and exposes the box springs and doorways to potential damage.", "In addition, the dimensions of a conventional box springs take up valuable retail floor space which discourages mass-market stores from offering box springs to their retail customers.", "Attempts have been made to develop folding mattress supports in the form of collapsible box springs or collapsible bed frames upon which a mattress can be directly placed.", "For example, FIG.", "1 (prior art) shows a foldable bedding foundation 10 as disclosed in U.S. Pat.", "No.", "7,376,988.Bedding foundation 10 has wire struts 11 that pivotally secure an upper wire grid 12 to wooden rails of the base 13.Wire braces 14 slide along the wire struts 11 and hold the bedding foundation 10 in an erected position when the foundation is unfolded.", "The two portions of the upper wire grid 12 are connected to each other by an upper hinge 15.Upper hinge 15 is a small piece of plastic that clips onto the border wires of each of the two portions of the upper wire grid 12.The two portions of the base 13 are connected to each other by a lower hinge 16, which is a piece of wire.", "Upper hinge 15 and lower hinge 16 are not attached to each other.", "The wire braces that slide along wire struts and the upper wire grids that are clipped together with a plastic hinge render bedding foundation 10 less sturdy than a conventional box springs.", "Moreover, bedding foundation 10 lacks a headboard and a footboard, so most consumers would prefer to place foundation 10 on another bed foundation whose aesthetic appearance more resembles a bed.", "A support for a mattress is sought that provides all of the support, comfort and aesthetic qualities of a conventional box springs supported by a bed foundation but yet that reduces the transportation and storage space requirements of a conventional bed and box springs combination.", "Moreover, the novel mattress support should be less flimsy than a foldable bed foundation that employs wire braces, wire struts, wire hinges and wire grids that are clipped together.", "SUMMARY A foldable mattress support includes a headboard frame, a central hinge portion, first and second portions of a bedboard frame and bracing struts.", "The headboard frame is parallel to the first portion when the foldable mattress support is completely collapsed and perpendicular to the first portion when the foldable mattress support is completely unfolded.", "The first portion and the second portion are pivotally attached to the central hinge portion.", "A first bracing strut is pivotally attached at a first location to a side bar of the first portion, and a second bracing strut is pivotally attached at a second location to the side bar.", "The first location and the second location are located on opposite sides of the side bar.", "The first bracing strut is longer than the second bracing strut.", "The second location is closer to the head end of the first portion than is the first location.", "The first bracing strut is pivotally attached at a third location to a post of the headboard frame, and the second bracing strut is pivotally attached at a fourth location to the post.", "The fourth location is closer to the top end of the post than is the third location.", "The first location is closer to the second location than the third location is to the fourth location.", "The bracing struts are used to rotate the headboard frame from a collapsed state that is parallel and adjacent to the first portion to an unfolded state that is perpendicular to the first portion without pivoting the headboard frame about any axis whose position is fixed with respect to the first portion.", "A footboard frame that is analogously attached to bracing struts is rotated from a collapsed state that is parallel and adjacent to the second portion to an unfolded state that is perpendicular to the second portion.", "When the mattress support is completely collapsed, the first portion is substantially parallel to the second portion with the headboard frame and footboard frame sandwiched between the two portions of bedboard frame.", "The posts of the headboard frame and the footboard frame are parallel to the legs of the central hinge portion when the foldable mattress support is completely unfolded.", "The bracing struts permit the headboard frame to be completely folded under the first portion of the bedboard frame without extending out beyond the head end despite the fact that the posts of the headboard frame are nearly as long as the side bars of first portion.", "For example, the posts of the headboard frame can be more than three quarters as long as the side bars of the first portion.", "A method of making and packaging a foldable mattress support includes folding down a headboard and a footboard and then folding a bedboard frame in half.", "A headboard frame is folded parallel to a first portion of the bedboard frame.", "The headboard is folded from a perpendicular orientation down and around the head end of the bedboard frame to being parallel and adjacent to the first portion.", "The folding is performed using bracing struts.", "A first bracing strut is pivotally attached at a first location to the first portion and at a third location to the headboard frame.", "A second bracing strut is pivotally attached at a second location to the first portion and at a fourth location to the headboard frame.", "The first bracing strut is longer than the second bracing strut.", "The first location is closer to the second location than the third location is to the fourth location.", "The footboard frame is also folded parallel and adjacent to the second portion.", "The first portion of the bedboard frame is then folded into the second portion of the bedboard frame.", "The first and second portions are pivotally attached to a central hinge portion.", "The first portion is pivotally attached at its center end to the central hinge portion.", "The second location is closer to the head end of the first portion than is the first location.", "The folded bedboard frame with the headboard and footboard sandwiched between the first and second portions is then inserted into a packing box.", "Instructions are also inserted into the packing box that instruct the user of the foldable mattress support to unfold the folded bedboard frame such that the headboard frame is perpendicular to the first portion.", "Further details and embodiments are described in the detailed description below.", "This summary does not purport to define the invention.", "The invention is defined by the claims.", "BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, where like numerals indicate like components, illustrate embodiments of the invention.", "FIG.", "1 (prior art) is a schematic diagram of a foldable bedding foundation that includes wire braces, wire struts, wire hinges and wire grids.", "FIG.", "2 is a perspective view of a novel collapsible, foldable mattress support that has the appearance of a conventional bed with a headboard, a footboard and a bedboard frame.", "FIG.", "3 is a perspective view of the mattress support of FIG.", "2 in a completely collapsed state.", "FIG.", "4 is a perspective view of the mattress support of FIG.", "3 in which a first portion of the bedboard is being unfolded from a second portion of the bedboard.", "FIGS.", "5A-F are schematic diagrams of six side views of the bedboard and the headboard as the mattress support of FIG.", "3 is unfolded after being unpacked from a packing box.", "FIG.", "5A shows the headboard adjacent to the bedboard frame before being unfolded.", "FIG.", "5B shows the headboard being folded out from under the bedboard frame.", "FIG.", "5C shows the headboard being folded out farther than in FIG.", "5B.", "FIG.", "5D shows the headboard being rotated towards a more vertical orientation.", "FIG.", "5E shows the headboard being folded out and rotated into an almost vertical orientation.", "FIG.", "5F shows the headboard in the completely unfolded state perpendicular to the bedboard frame.", "FIG.", "6 is a perspective view of the first portion of the bedboard frame as the headboard has just begun to be folded out from under the first portion.", "FIG.", "7 is a perspective view of the first portion of the bedboard frame as the headboard is folded out farther from under the first portion as illustrated in FIG.", "5B.", "FIG.", "8 is a perspective view of the first portion of the bedboard frame as the headboard has been folded out from under the first portion to the position shown in FIG.", "5D.", "FIG.", "9 is a perspective view of the first portion of the bedboard frame as the headboard has been folded out from under the first portion to the position shown in FIG.", "5E.", "FIG.", "10 is a perspective view of the headboard that has been completely unfolded to a position perpendicular to the first portion as shown in FIG.", "5F.", "FIG.", "11 is a perspective view of the second portion of the bedboard frame as the footboard is folded out from under the second portion.", "FIG.", "12 is a perspective view of the second portion of the bedboard frame as the footboard has been folded out from under the second portion past the position shown in FIG.", "11.FIG.", "13 is a flowchart of steps of a method of making and packaging the foldable mattress support of FIG.", "3.FIG.", "14 is a perspective view of the collapsible, foldable mattress support of FIG.", "2 upon which a mattress has been placed.", "DETAILED DESCRIPTION FIG.", "2 shows a sturdy, collapsible, foldable mattress support 20 that has the appearance of a conventional bed frame with a headboard frame 21 and a footboard frame 22.The headboard frame 21 and the footboard frame 22 fold out from under a bedboard frame 23.Foldable mattress support 20 has a central hinge portion 24 at its middle axis at which a first portion 25 of bedboard frame 23 unfolds from a second portion 26 of the bedboard frame.", "First portion 25 has a head end 27 and a center end 28.In a completely unfolded state, the head end 27 of first portion 25 contacts headboard frame 21 when the head end of a side bar 29 of first portion 25 abuts a post 30 of headboard frame 21.In the completely unfolded state as shown in FIG.", "2, headboard frame 21 is perpendicular to first portion 25 of bedboard frame 23.Similarly, in the completely unfolded state, footboard frame 22 is perpendicular to second portion 26.As the headboard frame 21 and footboard frame 22 are unfolded from under the bedboard frame 23, they are guided by bracing struts 31 from being parallel to the first and second portions of the bedboard frame to being perpendicular to the first and second portions of the bedboard frame.", "Central hinge portion 24 has two legs 32-33 connected by a bar 34.In addition, central hinge portion 24 has plates that form hinges that pivotally attach the side bars of the first and second portions of the bedboard frame 23.Two of the plates are connection by a beam 35 (not visible in FIG.", "2).", "First portion 25 has side bars 29 and 36, and second portion 26 has side bars 37-38.Headboard frame 21 has posts 30 and 39, and footboard frame 22 has posts 40-41.In the unfolded and assembled state, bar 29 abuts against post 30, bar 36 abuts against post 39, bar 37 abuts against post 40, and bar 38 abuts against post 41.The bars of bedboard frame 23 contact the posts of headboard frame 21 closer to a foot end 42 than to a top end 43 of the headboard frame.", "FIG.", "2 shows that post 30 of headboard frame 21 is parallel to leg 32 of central hinge portion 24 when foldable mattress support 20 is completely unfolded.", "In the description and claims, terms such as “over”, “under”, “top”, “bottom”, “up”, and “down” are used to describe relative directions and orientations between different parts of the mattress support system, and it is to be understood that the overall structure being described can actually be oriented in any way in three-dimensional space.", "For example, when the headboard is described as being unfolded out from under the bedboard frame, it is to be understood that the headboard may in fact be folded down and over the end of the bedboard frame or even around the end of the bedboard frame.", "When a first object is referred to as being disposed “over” or “on” a second object, it is to be understood that the first object can be directly on the second object, or an intervening object may be present between the first and second objects.", "FIG.", "3 shows mattress support 20 of FIG.", "2 in a completely collapsed or folded state.", "In the folded state, mattress support 20 is very compact and occupies less than half the volume of a conventional box springs sized for the same mattress size as mattress support 20.When mattress support 20 is completely collapsed, first portion 25 is substantially parallel to the second portion 26 with the headboard frame and footboard frame sandwiched between the two portions of bedboard frame 23.The novel use of the bracing struts 31 permit headboard frame 21 to be completely folded under first portion 25 of bedboard frame 23 without extending out beyond head end 27, despite the fact that the posts 30 and 39 of headboard frame 21 are nearly as long as the side bars of first portion 25.In the embodiment of FIG.", "2, for example, post 30 of headboard frame 21 is more than three quarters as long as side bar 29 of first portion 25.The predetermined lengths and pivoting axes of the bracing struts 31 allow headboard frame 21 to rotate from an unfolded state that is perpendicular to first portion 25 to a collapsed state that is parallel and adjacent to first portion 25 without pivoting headboard frame 21 about any axis whose position is fixed with respect to first portion 25.Because bedboard frame 23 does not meet headboard frame 21 at the foot end 42 or top end 43, it would not be possible to fold headboard frame 21 completely under first portion 25 if headboard frame 21 were to pivot about any axis that is fixed compared to first portion 25, such as if a simple rotating hinge were to connect side bar 29 to post 30.By manufacturing the mattress support 20 so that it can fold flat with headboard frame 21 between the portions of bedboard frame 23, the mattress support can be packaged in a smaller box whose dimensions are more likely to fit in the trunk of a car.", "Thus, mattress support 20 is better suited than a conventional box springs for sale in mass-market retail stores.", "The smaller packing box containing the collapsed mattress support 20 can more easily be brought from the store shelf to the check-out counter and then to the trunk of the consumer's car.", "In addition, it is easier to move collapsed mattress support 20 into an apartment elevator, up a staircase or through bedroom doors.", "FIG.", "4 illustrates how mattress support 20 is initially unfolded after being removed from a packing box in the completely collapsed state of FIG.", "3.The consumer first unfolds second portion 26 from first portion 25.Each of the first and second portions has two side bars that are connected by six tubular bars 44 and two beams 45 at the ends.", "First portion 25 and second portion 26 are both pivotally attached to central hinge portion 24.However, the two portions 25-26 of bedboard frame 23 rotate about two separate axes 46-47, respectively, that pass through plates of the central hinge portion 24.First portion 25 is pivotally attached at axis 46 at its center end 28 to central hinge portion 24.FIG.", "4 shows beam 35 that connects two of the inner plates of hinge portion 24.FIG.", "4 also shows that each of the posts 30 and 39 of headboard frame 21 is more than three quarters as long as each of the side bars 29 and 36 of first portion 25.Headboard frame 21 is thereby sufficiently tall to be distinguishable from footboard 22 and to impart the aesthetic appearance of a traditional bed frame.", "FIGS.", "5A-F are schematic diagrams of six side views of first portion 25 of foldable mattress support 20 as headboard frame 21 is being folded out from under bedboard frame 23.FIG.", "5A shows post 30 of headboard frame 21 adjacent to and parallel to side bar 29 of first portion 25 as shown in FIG.", "4 before headboard frame 21 is unfolded.", "FIG.", "5B shows post 30 of headboard frame 21 being folded out from under bedboard frame 23.The term “under” is used to describe only a relative position.", "In use, headboard frame 21 is unfolded by the consumer while mattress support 20 is positioned on its side.", "Thus, headboard frame 21 is actually unfolded around head end 27 of first portion 25.FIG.", "5B shows a first bracing strut 48 and a second bracing strut 49 that are pivotally attached both to side bar 29 of first portion 25 and to post 30 of headboard frame 21.First bracing strut 48 is longer than second bracing strut 49.First bracing strut 48 is pivotally attached at a first location 50 to side bar 29, and second bracing strut 49 is pivotally attached at a second location 51 to side bar 29.Second location 51 is closer to head end 27 of first portion 25 than is first location 50.First bracing strut 48 is pivotally attached at a third location 52 to post 30 of headboard frame 21, and second bracing strut 49 is pivotally attached at a fourth location 53 to post 30.Fourth location 53 is closer to top end 43 of post 30 than is third location 52.In addition, first location 50 is closer to second location 51 than third location 52 is to fourth location 53.First location 50 and second location 51 are located on opposite sides of side bar 29, and third location 52 and fourth location 53 are located on opposite sides of post 30.In the embodiment of FIG.", "2, first bracing strut 48 is pivotally attached to the outside surfaces of bar 29 and post 30, whereas second bracing strut 49 is pivotally attached to surfaces of bar 29 and post 30 that do not face outwards from mattress support 20.In FIG.", "5, second bracing strut 49 has a dashed outline to represent that the strut rotates on the other side of side bar 29 from the viewer.", "In addition to first bracing strut 48 and second bracing strut 49 that rotatably connect post 30 to side bar 29, two analogous bracing struts connect each of posts 39-41 to the side bars 36-39.The bracing struts are pivotally attached to the bars and posts by bolts, nuts and washers.", "The struts are made of flat bars of metal.", "FIG.", "5C shows post 30 of headboard frame 21 being folded out farther from under side bar 29 than in FIG.", "5B.", "Because first bracing strut 48 is longer than second bracing strut 49, and pivot axis locations 50-51 are closer together than are pivot axis locations 52-53, foot end 42 of headboard frame 21 is pushed downward relative to top end 43 as the headboard frame is moved towards the head end 27 of bedboard frame 23.When the bracing struts 48-49 are more or less vertical as shown in FIG.", "5C, top end 43 of headboard frame 21 is already above head end 27 of bedboard frame 23.FIG.", "5D shows headboard frame 21 being rotated towards a more vertical orientation than in FIG.", "5C.", "A path 54 is illustrated through which first bracing strut 48 causes third location 52 to rotate about first location 50.In addition, FIG.", "5D shows a path 55 through which second bracing strut 49 causes fourth location 53 to rotate about second location 51.The paths 54-55 and the fixed distance 56 between locations 52-53 on those paths illustrate how the struts 48-49 rotate the orientation of headboard frame 21 from parallel to bedboard frame 23 to perpendicular to bedboard frame 23 as headboard frame 21 moves down and around top end 43 of bedboard frame 23.FIG.", "5E shows post 30 of headboard frame 21 being folded out and rotated into an almost vertical orientation.", "And finally FIG.", "5F shows headboard frame 21 in the completely unfolded state perpendicular to bedboard frame 21.FIG.", "6 is a perspective view of first portion 25 of bedboard frame 23 as headboard frame 21 has just begun to be folded out from under first portion 25.The consumer is instructed to stand mattress support 20 on its side after unfolding first portion 25 from second portion 26.Thus, the unfolding step shown in FIG.", "6 would preferably be performed by pulling headboard frame 21 from the side away from first portion 25.FIG.", "7 is a perspective view of first portion 25 of bedboard frame 23 as headboard frame 21 is unfolded to a degree analogous to that shown in FIG.", "5B.", "In FIG.", "7, headboard frame 21 is folded out farther from under first portion 25 than as illustrated in FIG.", "6.The relative positions of longer first bracing strut 48 and shorter second bracing strut 49 are shown that connect bar 29 and post 30 beneath the bars 44 of first portion 25.FIG.", "8 is a perspective view of first portion 25 of bedboard frame 23 as headboard frame 21 has been folded out from under first portion 25 to a position similar to that shown in FIG.", "5D.", "FIG.", "8 shows a longer bracing strut 57 and a shorter bracing strut 58 that connect bar 36 and post 39 on the opposite side of bedboard frame 23 from first bracing strut 48 and second bracing strut 49.Struts 57-58 rotate post 39 in an analogous manner to how struts 48-49 rotate post 30 up and around head end 27 of first portion 25.Bracing struts 48-49 and 57-58 are a means for rotating headboard frame 21 from a collapsed state that is parallel and adjacent to first portion 25 to an unfolded state that is perpendicular to first portion 25 without pivoting headboard frame 21 about any axis whose position is fixed with respect to first portion 25.This allows a taller headboard to be folded completely under first portion 25 so that the collapsed state of foldable mattress support 20 is not wider than the length of the side bars 29 and 36.FIG.", "9 is a perspective view of first portion 25 of bedboard frame 23 as headboard frame 21 has been folded out from under first portion 25 to a position similar to that shown in FIG.", "5E where headboard frame 21 is approaching a vertical orientation.", "FIG.", "10 shows foldable mattress support 20 in a completely unfolded state when headboard frame 21 is perpendicular to bedboard frame 23 and the head ends of side bars 29 and 36 of first portion 25 abut the posts 30 and 39 of headboard frame 21.Head end 27 of first portion 25 contacts the posts 30 and 39 of headboard frame 21 at locations that are closer to the foot ends than the top ends of the posts 30 and 39.The consumer is instructed to immovably secure the headboard frame 21 to the bedboard frame 23 in the completely unfolded state by inserting bolts 59-60 through the posts 30 and 39 and screwing them into the ends of the side bars 29 and 36.FIG.", "11 is a perspective view of second portion 26 of bedboard frame 23 as footboard 22 is being folded out from under second portion 26.Bracing struts 61-64 are used to rotate footboard 22 from a position parallel and adjacent to second portion 26 to a perpendicular orientation.", "Bracing struts 61-64 operate on footboard 22 in a manner analogous to how bracing struts 48-49 and 57-58 rotate headboard frame 21.FIG.", "12 shows second portion 26 of bedboard frame 23 as footboard 22 has been folded out from under second portion 26 past the position shown in FIG.", "11 to a nearly perpendicular orientation.", "FIG.", "13 is a flowchart illustrating steps 65-69 of a method of packing foldable mattress support 20 into a packing box that is conveniently sized for transporting.", "In a first step 65, headboard frame 21 is folded parallel to first portion 25 of bedboard frame 23.Headboard frame 21 is rotated from a perpendicular orientation to a position parallel and adjacent to the underside of first portion 25 by being folded down and around head end 27 of first portion 25.Headboard frame 21 is folded by means of four bracing struts 48-49 and 57-58.First bracing strut 48 is pivotally attached at first location 50 to first portion 25 and at third location 52 to headboard frame 21.Second bracing 49 strut is pivotally attached at second location 51 to first portion 25 and at fourth location 53 to headboard frame 21.First location 50 is closer to second location 51 than third location 52 is to fourth location 53.In a second step 66, footboard 22 is folded parallel to second portion 26 of bedboard frame 23.Footboard 22 is folded down and around the foot end of second portion 26 by being rotated from a perpendicular orientation to a position parallel and adjacent to the underside of second portion 26.In a step 67, first portion 25 of bedboard frame 23 is folded into second portion 26 of bedboard frame 23.First portion 25 and second portion 26 are pivotally attached to central hinge portion 24.Bedboard frame 23 is folded over at two axes the pass through central hinge portion 24.After first portion 25 is folded into second portion 26, headboard frame 21 and footboard 22 are sandwiched between the two portions 25-26, as shown in FIG.", "3.In the completely folded state achieved after step 67, the bars 29 and 36-38 and posts 30 and 39-41 are substantially parallel to one another.", "In a step 68, the folded bedboard frame 23 as shown in FIG.", "3 is inserted into a packing box.", "The packing box has a length that is slightly longer than the bars 44 and beams 45, and a width that is marginally longer than the side bars 29 and 36-38.The packing box has a height that is slightly greater than the sum of the widths of two bars 29 and 36-38 plus two posts 30 and 39-41.In a step 69, instructions are inserted into the packing box instructing the user of foldable mattress support 20 how to unfold the folded mattress support after removing it from the packing box.", "The instructions instruct the user to unfold the folded bedboard frame 23 and to place a mattress on top of the unfolded bedboard frame.", "FIG.", "14 shows collapsible, foldable mattress support 20 of FIG.", "2 upon which a mattress 70 has been placed.", "By manufacturing the mattress support 20 so that it can fold in half and collapse flat, the mattress support is better suited to sell in mass-market retail stores and can more easily be transported from the store to the location of the mattress to be supported.", "The large dimensions of a conventional box springs and bed frame take up valuable floor space in mass-market stores.", "Less floor space is needed to display boxes of the foldable mattress support 20 on store shelves.", "The large size and unitary construction of a conventional box spring also make it impractical for a consumer to transport the box springs home from a mass-market retail store.", "The small packing box capable of containing the collapsed mattress support 20, however, can be brought from the store shelf to the check-out counter and then to the trunk of the consumer's car.", "In addition, the damage that occurs when conventional one-piece wooden box springs are moved through doorways can be avoided.", "The packing box that contains foldable mattress support 20 can more easily be maneuvered up stairs, into apartment elevators and around corners than would a conventional non-collapsible box springs and a bed frame.", "Although certain specific embodiments are described above for instructional purposes, the teachings of this patent document have general applicability and are not limited to the specific embodiments described above.", "Accordingly, various modifications, adaptations, and combinations of various features of the described embodiments can be practiced without departing from the scope of the invention as set forth in the claims." ] ]
Patent_15876149
[ [ "MOLECULAR CHEMICAL IMAGING ENDOSCOPIC IMAGING SYSTEMS", "The instant disclosure provides for medical imaging systems that may be used in conjunction with an intraoperative medical device, such as an endoscope.", "Generally, the disclosed medical imaging systems include an illumination source configured to generate illuminating photons for illuminating a biological sample.", "An optical signal modulator is configured to separate one or more of the illuminating photons and photons that have interacted with the biological sample into a first optical signal having first multi-passband wavelengths and a second optical signal having second multi-passband wavelengths.", "At least one detector is configured to detect one or more of the first optical signal and the second optical signal and generate at least one image data set.", "A processor is configured to analyze the at least one image data set.", "In some embodiments, the processor is configured to differentiate between structures of the biological sample, such as between an ureter and surrounding tissue." ], [ "1-57.", "(canceled) 58.An intraoperative device comprising: an imaging system including: an illumination source configured to generate a plurality of illuminating photons to illuminate a biological sample and produce a plurality of interacted photons; an optical signal modulator configured to receive one or more of the plurality of illuminating photons and the plurality of interacted photons and generate a first optical component and a second optical component; at least one detector configured to detect one or more of the first optical component and the second optical component and generate at least one image data set; and a processor configured to analyze the at least one image data set.", "59.The device of claim 58, wherein the illumination source includes one or more of a halogen light source, a metal halide light source, a light emitting diode (LED), an LED array, a pulsed LED, a pulsed LED array, a laser, and a pulsed laser.", "60.The device of claim 58, wherein the optical signal modulator comprises one or more of a plurality of conformal filters, a liquid crystal tunable filter, a multi-conjugate filter, a plurality of multivariate optical elements, and an acousto-optic tunable filter.", "61.The device of claim 58, wherein the detector comprises one or more of a CCD detector, a complementary metal-oxide-semiconductor (CMOS) detector, an indium gallium arsenide (InGaAs) detector, a platinum silicide (PtSi) detector, an indium antimonide (InSb) detector, and a mercury cadmium telluride (HgCdTe) detector.", "62.The device of claim 58, wherein the at least one detector is configured to generate a first image data set (T1) and a second image data set (T2).", "63.The device of claim 62, wherein the processor is configured to analyze the at least one data set by applying an optical computation to one or more of the first image data set (T1) and the second image data set (T2).", "64.The device of claim 58, wherein the processor is further configured to apply a digital stain to the at least one image data set.", "65.The device of claim 58, wherein the processor is configured to analyze the at least one image data set to differentiate structures of the biological sample.", "66.The device of claim 65, wherein the structures include a ureter and surrounding tissue.", "67.The device of claim 58, wherein the processor is configured to analyze the at least one image data set by applying one or more chemometric techniques selected from a group consisting of a multivariate curve resolution analysis, a principle component analysis (PCA), a partial least squares discriminant analysis (PLSDA), a k means clustering analysis, a band t entropy analysis, an adaptive subspace detector analysis, a cosine correlation analysis, a Euclidian distance analysis, a partial least squares regression analysis, a spectral mixture resolution analysis, a spectral angle mapper metric analysis, a spectral information divergence metric analysis, a Mahalanobis distance metric analysis, and a spectral unmixing analysis.", "68.The device of claim 58, wherein the at least one image data set includes a hyperspectral image.", "69.The device of claim 58, wherein the first optical component comprises first multi-passband wavelengths and the second optical component comprises second multi-passband wavelengths.", "70.The device of claim 58, wherein the optical signal modulator comprises a patterned etalon filter arrangement configured to receive the plurality of interacted photons.", "71.The device of claim 58, wherein the optical signal modulator is configured to modulate the plurality of illuminating photons.", "72.The device of claim 71, wherein the optical signal modulator comprises one or more of a plurality of conformal filters in a dual polarization arrangement and a plurality of multivariate optical elements.", "73.The device of claim 58, wherein the optical signal modulator is configured to modulate the plurality of interacted photons.", "74.The device of claim 58, wherein the optical signal modulator comprises one or more of a conformal filter, a liquid crystal tunable filter, a multi-conjugate filter, an acousto-optic filter, a plurality of multi-optic elements, and a patterned etalon filter.", "75.The device of claim 58, wherein the at least one detector comprises a first detector configured to detect the first optical component and a second detector configured to detect the second optical component.", "76.An endoscopic instrument comprising: a tubular body having a lumen therethrough, the tubular body having a proximal end and an operable end; an illumination source optically connected to the operable end and configured to illuminate a biological sample and generate a plurality of interacted photons; a collection optic disposed on the operable end; an optical signal modulator optically connected to the collection optic and configured to receive the plurality of interacted photons and separate the plurality of interacted photons into a first optical component and a second optical component; at least one detector configured to detect one or more of the first optical component and the second optical component and generate at least one image data set; and a processor configured to analyze the at least one image data set.", "77.The instrument of claim 76, wherein the illumination source includes one or more of a halogen light source, a metal halide light source, a light emitting diode (LED), an LED array, a pulsed LED, a pulsed LED array, a laser, and a pulsed laser.", "78.The instrument of claim 76, wherein the optical signal modulator comprises one or more of a plurality of conformal filters in dual polarization arrangement and a plurality of multivariate optical elements.", "79.The instrument of claim 76, wherein the at least one detector comprises one or more of a CCD detector, a complementary metal-oxide-semiconductor (CMOS) detector, an indium gallium arsenide (InGaAs) detector, a platinum silicide (PtSi) detector, an indium antimonide (InSb) detector, a mercury cadmium telluride (HgCdTe) detector.", "80.The instrument of claim 76, wherein the at least one detector is configured to generate a first image data set (T1) and a second image data set (T2).", "81.The instrument of claim 80, wherein the processor is configured to analyze the at least one image data set by applying an optical computation to the first image data set (T1) and the second image data set (T2).", "82.The instrument of claim 76, wherein the processor is further configured to apply a digital stain to the at least one image data set.", "83.The instrument of claim 76, wherein the processor is configured to analyze the at least one image data set to differentiate structures of the biological sample.", "84.The device of claim 76, wherein the structures include a ureter and surrounding tissue.", "85.The instrument of claim 76, wherein the processor is configured to analyze the at least one image data set by applying one or more chemometric techniques selected from a group consisting of a multivariate curve resolution analysis, a principle component analysis (PCA), a partial least squares discriminant analysis (PLSDA), a k means clustering analysis, a band t entropy analysis, an adaptive subspace detector analysis, a cosine correlation analysis, a Euclidian distance analysis, a partial least squares regression analysis, a spectral mixture resolution analysis, a spectral angle mapper metric analysis, a spectral information divergence metric analysis, a Mahalanobis distance metric analysis, and a spectral unmixing analysis.", "86.The instrument of claim 76, wherein the at least one image data set includes a hyperspectral image.", "87.The instrument of claim 76, wherein the first optical component comprises first multi-passband wavelengths and the second optical component comprises second multi-passband wavelengths.", "88.The instrument of claim 76, wherein the optical signal modulator comprises a patterned etalon filter arrangement.", "89.The instrument of claim 76, wherein the at least one detector comprises a first detector configured to detect the first optical component and a second detector configured to detect the second optical component.", "90.An endoscopic instrument comprising: a tubular body having a lumen therethrough, the tubular body having a proximal end and an operable end; an illumination source configured to generate a plurality of illuminating photons; an optical signal modulator configured to receive the plurality of illuminating photons and separate the plurality of illuminating photons into a first optical component and a second optical component; a fiber optic configured to transmit the first optical component and the second optical component through the lumen to the operable end to illuminate a biological sample; a collection optic disposed on the operable end; at least one detector optically coupled to the collection optic and configured to detect one or more of the first optical component and the second optical component and generate at least one image data set; and a processor configured to analyze the at least one image data set.", "91.The instrument of claim 90, wherein the illumination source includes one or more of a halogen light source, a metal halide light source, a light emitting diode (LED), an LED array, a pulsed LED, a pulsed LED array, a laser, and a pulsed laser.", "92.The instrument of claim 90, wherein the optical signal modulator comprises one or more of a plurality of conformal filters in dual polarization arrangement and a plurality of multivariate optical elements.", "93.The instrument of claim 90, wherein the at least one detector comprises one or more of a CCD detector, a complementary metal-oxide-semiconductor (CMOS) detector, an indium gallium arsenide (InGaAs) detector, a platinum silicide (PtSi) detector, an indium antimonide (InSb) detector, a mercury cadmium telluride (HgCdTe) detector.", "94.The instrument of claim 90, wherein the at least one detector is configured to generate a first image data set (T1) and a second image data set (T2).", "95.The device of claim 94, wherein the processor is configured to analyze the at least one image data set by applying an optical computation to the first image data set (T1) and the second image data set (T2).", "96.The device of claim 90, wherein the processor is further configured to apply a digital stain to the at least one image data set.", "97.The instrument of claim 90, wherein the processor is configured to analyze the at least one image data set to differentiate structures of the biological sample.", "98.The instrument of claim 97, wherein the structures include a ureter and surrounding tissue.", "99.The instrument of claim 90, wherein the processor is configured to analyze the at least one image data set by applying one or more chemometric techniques selected from a group consisting of a multivariate curve resolution analysis, a principle component analysis (PCA), a partial least squares discriminant analysis (PLSDA), a k means clustering analysis, a band t entropy analysis, an adaptive subspace detector analysis, a cosine correlation analysis, a Euclidian distance analysis, a partial least squares regression analysis, a spectral mixture resolution analysis, a spectral angle mapper metric analysis, a spectral information divergence metric analysis, a Mahalanobis distance metric analysis, and a spectral unmixing analysis.", "100.The instrument of claim 90, wherein the at least one image data set includes a hyperspectral image.", "101.The instrument of claim 90, wherein the first optical component comprises first multi-passband wavelengths and the second optical component comprises second multi-passband wavelengths.", "102.The instrument of claim 90, wherein the at least one detector comprises a first detector configured to detect the first optical component and a second detector configured to detect the second optical component.", "103.A method of differentiating anatomical structures in a biological sample, comprising: illuminating the biological sample with a plurality of illuminating photons to generate a plurality of interacted photons; modulating one or more of the plurality of illuminating photons and the plurality of interacted photons into a first optical component and a second optical component; detecting one or more of the first optical component and the second optical component to generate at least one image data set; and analyzing the at least one image data set to differentiate the anatomical structures.", "104.The method of claim 103, wherein modulating comprises passing one or more of the plurality of illuminating photons and the plurality of interacted photons through one or more of a plurality of tunable conformal filters, a plurality of multivariate optical elements, a liquid crystal tunable filter, a multi-conjugate filter, an acousto-optic filter, a plurality of multivariate optical elements, and a patterned etalon filter.", "105.The method of claim 103, wherein detecting comprises generating a first image data set (T1) and a second image data set (T2).", "106.The method of claim 105, wherein analyzing comprises applying an optical computation to the first image data set (T1) and the second image data set (T2).", "107.The method of claim 103, wherein analyzing comprises applying a digital stain to the at least one image data set.", "108.The method of claim 103, wherein differentiating anatomical structures comprises differentiating an ureter from surrounding tissue.", "109.The method of claim 103, wherein analyzing comprises applying one or more chemometric techniques to the at least one image data set, the one or more chemometric techniques being selected from a group consisting of a multivariate curve resolution analysis, a principle component analysis (PCA), a partial least squares discriminant analysis (PLSDA), a k means clustering analysis, a band t entropy analysis, an adaptive subspace detector analysis, a cosine correlation analysis, a Euclidian distance analysis, a partial least squares regression analysis, a spectral mixture resolution analysis, a spectral angle mapper metric analysis, a spectral information divergence metric analysis, a Mahalanobis distance metric analysis, and a spectral unmixing analysis.", "110.The method of claim 103, wherein detecting the first optical component comprises detecting first multi-passband wavelengths and detecting the second optical component comprises detecting second multi-passband wavelengths.", "111.The method of claim 103, wherein modulating comprises modulating the plurality of illuminating photons.", "112.The method of claim 103, wherein modulating comprises modulating the plurality of interacted photons." ], [ "<SOH> BACKGROUND <EOH>In performing surgery on the human body, it is essential that surgeons do not accidentally cut or otherwise harm organs, passages or other anatomical structures such as the urethra and ureter.", "The presence of blood, fat, arteries, veins, intervening tissue such as muscle and fascia and other highly scattering and absorbing media can make it extremely difficult to locate with great accuracy such organs, passages and anatomical structures in the immediate vicinity of the surgical site.", "Light emitting catheters have been used to detect irregularities in a duct, vessel or organ to assist a surgeon in locating anatomical structures of interest to permit the proper performance of the surgical procedure.", "However, there exists a need for improved intraoperative imaging tools which are capable of real-time detection of anatomical structures in assisting surgeons performing delicate operations without harming tissue surrounding the surgical site." ], [ "<SOH> SUMMARY OF THE DISCLOSURE <EOH>The instant disclosure provides medical imaging systems.", "The medical imaging systems may be used in conjunction with an endoscope.", "Generally, the medical imaging system includes an illumination source configured to generate illuminating photons.", "The illuminating photons are transmitted to one or more filters configured to filter a first plurality of illuminating photons and generate a first plurality of filtered photons comprising a first passband wavelength and a second plurality of filtered photons comprising a second passband wavelength.", "A sample is then illuminated with the first plurality of filtered photons and the second plurality of filtered photons to generate a first plurality of interacted photons and a second plurality of interacted photons.", "One or more detectors are configured to detect the first plurality of interacted photons and the second plurality of interacted photons and generate one or more image data sets.", "In another embodiment, the imaging system includes an illumination source configured to illuminate a sample and generate interacted photons.", "One or more filters are configured to filter one or more of a first plurality of the interacted photons and transmit a first passband wavelength and a second plurality of the interacted photons and transmit a second passband wavelength.", "The first and second passband wavelengths are transmitted to one or more detectors configured to detect the first passband wavelength and the second passband wavelength and generate one or more image data sets.", "In yet another embodiment, the imaging system features an illumination source configured to illuminate a sample with one or more of a first plurality of illuminating photons having a first wavelength to generate a first plurality of interacted photons and a second plurality of illuminating photons having a second wavelength to generate a second plurality of interacted photons.", "One or more detectors are configured to detect the first plurality of interacted photons and the second plurality of interacted photons to generate one or more image data sets." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application claims benefit of and priority to U.S.", "Provisional Patent Application No.", "62/089,777 entitled “Molecular Chemical Imaging Endoscopic Imaging Systems,” filed Dec. 9, 2014, the disclosure of which is incorporated by reference herein in its entirety.", "This application further claims benefit of and priority to U.S.", "Provisional Patent Application No.", "62/113,958 entitled “Molecular Chemical Imaging Endoscopic Imaging Systems,” filed Feb. 9, 2015, the disclosure of which is incorporated by reference herein in its entirety.", "BACKGROUND In performing surgery on the human body, it is essential that surgeons do not accidentally cut or otherwise harm organs, passages or other anatomical structures such as the urethra and ureter.", "The presence of blood, fat, arteries, veins, intervening tissue such as muscle and fascia and other highly scattering and absorbing media can make it extremely difficult to locate with great accuracy such organs, passages and anatomical structures in the immediate vicinity of the surgical site.", "Light emitting catheters have been used to detect irregularities in a duct, vessel or organ to assist a surgeon in locating anatomical structures of interest to permit the proper performance of the surgical procedure.", "However, there exists a need for improved intraoperative imaging tools which are capable of real-time detection of anatomical structures in assisting surgeons performing delicate operations without harming tissue surrounding the surgical site.", "SUMMARY OF THE DISCLOSURE The instant disclosure provides medical imaging systems.", "The medical imaging systems may be used in conjunction with an endoscope.", "Generally, the medical imaging system includes an illumination source configured to generate illuminating photons.", "The illuminating photons are transmitted to one or more filters configured to filter a first plurality of illuminating photons and generate a first plurality of filtered photons comprising a first passband wavelength and a second plurality of filtered photons comprising a second passband wavelength.", "A sample is then illuminated with the first plurality of filtered photons and the second plurality of filtered photons to generate a first plurality of interacted photons and a second plurality of interacted photons.", "One or more detectors are configured to detect the first plurality of interacted photons and the second plurality of interacted photons and generate one or more image data sets.", "In another embodiment, the imaging system includes an illumination source configured to illuminate a sample and generate interacted photons.", "One or more filters are configured to filter one or more of a first plurality of the interacted photons and transmit a first passband wavelength and a second plurality of the interacted photons and transmit a second passband wavelength.", "The first and second passband wavelengths are transmitted to one or more detectors configured to detect the first passband wavelength and the second passband wavelength and generate one or more image data sets.", "In yet another embodiment, the imaging system features an illumination source configured to illuminate a sample with one or more of a first plurality of illuminating photons having a first wavelength to generate a first plurality of interacted photons and a second plurality of illuminating photons having a second wavelength to generate a second plurality of interacted photons.", "One or more detectors are configured to detect the first plurality of interacted photons and the second plurality of interacted photons to generate one or more image data sets.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates an endoscope comprising an imaging system having a plurality of conformal filters in a dual polarization configuration, according to an embodiment; FIG.", "1A is an end-on view of the endoscope according to the embodiment in FIG.", "1; FIG.", "1B illustrates a patterned conformal filter configuration with a CCD detector, according to an embodiment; FIG.", "2 illustrates an endoscope comprising an imaging system having a plurality of multivariate optical element (MOE) filters, according to an embodiment; FIG.", "2A is an end-on view of the endoscope according to the embodiment in FIG.", "2; FIG.", "2B is a cross-sectional view of the distal end of the endoscope according to the embodiment in FIG.", "2; FIG.", "3 illustrates an endoscope comprising an imaging system having a conformal filter, according to an embodiment; FIG.", "3A is an end-on view of the endoscope according to the embodiment in FIG.", "3; FIG.", "4 illustrates an endoscope comprising an imaging system having a plurality of conformal filters in a dual polarization configuration for source illumination modulation, according to an embodiment; FIG.", "4A is an end-on view of the endoscope according to the embodiment in FIG.", "4; FIG.", "4B is an end-on view of an alternate embodiment of the endoscope according to the embodiment in FIG.", "4; FIG.", "5 illustrates an endoscope comprising an imaging system having an acousto-optic filter, according to an embodiment; FIG.", "5A is an end-on view of the endoscope according the embodiment in FIG.", "5; FIG.", "6 illustrates an endoscope comprising an imaging system having a MOE filter wheel, according to an embodiment; FIG.", "6A is an end-on view of the endoscope according to the embodiment in FIG.", "6; FIG.", "7 illustrates an endoscope comprising an imaging system having a patterned etalon filter arrangements, according to an embodiment; and DETAILED DESCRIPTION The present disclosure features intraoperative medical imaging systems which can assist surgeons in various medical procedures.", "The systems disclosed herein are suitable for use as stand-alone devices, or may be incorporated into other medical imaging devices such as a robotic platform.", "In one embodiment, the systems disclosed herein may be used in conjunction with an endoscope.", "The medical imaging systems disclosed herein may provide real-time detection of tumors and anatomic structures during endoscopic procedures.", "Generally, the systems disclosed herein provide illuminating a biological sample, collecting photons that have interacted with the sample, detecting the interacted photons to generate an image data set of the sample, and analyzing the image data set.", "Interacted photons may comprise one or more of photons absorbed by a sample, photons reflected by a sample, photons scattered by a sample, and photons emitted by a sample.", "In one embodiment, the medical imaging system provides multivariate imaging.", "Multivariate imaging features generating two or more wavelengths corresponding to a first image data set (T1) and a second image data set (T2).", "These first and second image data sets may be analyzed using an optical computation.", "Multivariate imaging creates enhanced image contrast and increased discrimination between a target and background.", "In certain embodiments, the first image data set and the second image data set feature hyperspectral image data.", "In another embodiment, the medical imaging systems feature imaging frame rates of >10 Hz (hyper-cubes/second).", "The systems disclosed herein may be used on various biological samples, such as tissues, organs, anatomical structures, physiological systems, cells, blood, fat, nerves, muscle and the like.", "In certain embodiments, the systems may be employed in various areas of the body, which would be apparent to one of skill in the art in view of this disclosure.", "For example, the systems might be employed to investigate and/or perform surgery in the gastrointestinal tract.", "In such an application, the systems may be employed in any of the esophagus, the stomach, the duodenum, the small intestine, the large intestine/colon, the bile duct, the rectum, the anus and the like.", "The systems may further be employed on structures of the respiratory tract including, without limitation, the nose, the sinuses and the lower respiratory tract.", "In other embodiments, the systems disclosed herein may be used to investigate and/or perform surgery on structures comprising the urinary tract, such as the bladder, ureter, kidneys and so forth.", "In yet other embodiments, the systems may be employed on structures comprising the female reproductive system, such as the cervix, uterus, fallopian tubes and the like.", "Further, the systems may be employed in medical procedures performed during pregnancy, such as to investigate and/or perform medical procedures on the amnion and fetus.", "In another embodiment, the systems described herein may be employed to investigate and/or perform surgery on the structures involving the musculoskeletal system, i.e., orthopaedics, including the structures of the hand, the knee, the elbow, the shoulder, the spine, including the epidural cavity, bursae, muscles, ligaments, connective tissues and the like.", "Further, the systems may be configured to discriminate between two or more different biological samples.", "For example, the systems disclosed herein may be configured to discriminate between a ureter and surrounding tissue and fat.", "In one embodiment, the systems disclosed herein may be employed to differentiate cancer from normal tissue, determine one or more of a cancer stage, cancer progression and cancer grade.", "In another embodiment, the systems may be employed during surgical procedures to remove cancer tissue or tumors found on the biological sample.", "In yet another embodiment, the systems described herein may be employed to differentiate anatomical structures by identifying a bodily fluid associated with such anatomic structures.", "Bodily fluids may include, for example, urine, saliva, sputum, blood, feces, mucus, pus, semen, lymph, wound exudate, mammary fluid, vaginal fluid and the like.", "Anatomical structures having an associated bodily fluid would be apparent to those of ordinary skill in the art.", "As disclosed herein, the systems of the present disclosure provide illumination to a biological tissue.", "It is known that such illumination may penetrate a biological sample up to several centimeters, depending on wavelength and tissue type.", "Thus, such illumination penetration permits the imaging of bodily fluids contained inside an anatomical structure.", "Further, the bodily fluids may be directly imaged where their presence resides outside of the anatomical structure or other biological sample.", "In another embodiment, the systems disclosed herein may be employed to identify a ureter by detecting urine in or around the ureter.", "In another embodiment, the instant systems may be employed with the use of one or more contrasting-enhancing agents.", "Contrast-enhancing agents may include one or more stains or dyes.", "When only one stain or dye is used, the procedure is referred to as staining.", "Multiple staining comprises the use of more than one stain or dye.", "As used herein, a “stain” or “dye” is any chemical or biological compound that can bind to a substance in a biological sample, to induce a color.", "For example, a stain or dye can bind to a particular cellular or biochemical structure (e.g., cell membrane, organelles, nucleic acid, protein) to induce contrasts when viewed using the systems described herein.", "In some embodiments, the stain or dye can induce a color by emitting electromagnetic radiation at one or more wavelengths when excited (i.e., fluoresce).", "The one or more stains or dyes can be used, for example, in vivo or ex vivo.", "In some embodiments, the stain or dye is any stain or dye suitable for use in a living organism/individual that does not kill cells, i.e., a biological stain.", "Examples of biological stains include, but are not limited to, azo dyes, arylmethane dyes, cyanine dyes, thiazine dyes, xanthene dyes (e.g., eosin), natural stains (e.g., alizarin red), steroids, trypan blue, janus green, indocyanine green, alizarin red, propidium iodide, erythrosine, 7-aminotinomycin D, and Nile blue.", "In one embodiment, the contrasting-enhancing agent is a fluorescent contrast-enhancing agent.", "In one embodiment, the contrast-enhancing agent may include a Flourophor.", "Suitable Fluorophores include an immuno-fluorescent compound, a basophilic compound, an acidophilic compound, neutral stains and naturally occurring luminescent molecules.", "When one or more stains or dyes are used in conjunction with the systems and methods described herein, a user (e.g., a surgeon) can intra-operatively identify histology, pathology, morphology, position, chemicals, and chemical reactions in or around the biological sample.", "For example, some (one or more) biological stains can identify cancerous cells so that the surgeon can resect the tumor.", "Other biological stains can also identify living cells (tissue) versus non-living cells.", "Once the contrast-enhancing agent is applied to the biological sample, the sample can be irradiated with photons having a wavelength within the illumination wavelength range of the applied contrast-enhancing agent in order to obtain spectral images as set forth in the instant disclosure.", "In another embodiment, the contrast-enhancing agent may be ingested by a subject, where the contrast-enhancing agent will appear in a bodily fluid.", "In one embodiment, the contrast-enhancing agent may be taken orally, through an IV or through other means as would be apparent to one of skill in the art in view of this disclosure.", "Once the contrast-enhancing agent is ingested, the target biological sample may be examined by the systems disclosed herein.", "The systems may be configured to detect the contrast-enhancing agent in the bodily fluid to provide contrast between structures comprising the bodily fluid and surrounding biological samples, such as surrounding tissue.", "For example, a patient may orally ingest a solution comprising a contrast-enhancing agent where the contrast-enhancing agent at a certain time thereafter appears in the patient's urine.", "A endoscopic procedure may be performed on the kidney area of the patient with a system according to the instant disclosure.", "The system is configured to detect the contrast-enhancing agent present in the urine located in an ureter to differentiate the ureter and other surrounding tissues.", "In another embodiment, a biological tissue may be imaged with a system according to the instant disclosure ex vivo.", "In such an application, the biological sample may be removed and analyzed outside of the surgical site.", "Traditional staining methods may be applied to the resected tissue to determine one or more biological characteristics of the sample.", "Ex vivo techniques are known in the art and would be apparent to one of skill in the art in view of this disclosure.", "In another embodiment, the biological sample may be enhanced by applying a digital stain to the sample.", "Digital stains are applied to an image data set by using an algorithm.", "The use of a digital stain eliminates the need to apply a physical and/or chemical stain to the biological sample.", "Digital stains may be applied to any of the image data sets obtained through the systems disclosed herein.", "One example of the application of a digital stain to a Raman data set may be found in U.S. Patent Application Publication Number 2012/0083678, filed as application Ser.", "No.", "13/200,779 on Sep. 30, 2011 to Drauch et al.", "and entitled SYSTEM AND METHOD FOR RAMAN CHEMICAL ANALYSIS OF LUNG CANCER WITH DIGITAL STAINING, assigned to ChemImage Corporation, Pittsburgh, Pa., the entirety of which is incorporated herein by reference.", "Not intending to limit the disclosure in any way, the instant disclosure is directed to analyzing a ureter via an endoscope.", "Other medical imaging instrumentation and the detection of other types of biological samples is further contemplated by the instant disclosure and would be apparent to those of skill in the art in view of the instant disclosure.", "The medical imaging instruments disclosed herein provide real-time multivariate imaging by generating a multivariate signal using one or more detectors.", "The detectors detect the multivariate signal to produce one or more image data sets.", "Provided herein are two ways to achieve this result.", "One such method includes illuminating a sample, collecting interacted photons that have interacted with the sample, and modulating the collected signal prior to passing the signal on to a detector.", "A second method includes modulating the illumination source signal prior to interaction with a sample, collecting interacted photons of the modulated signal, and detecting the interacted photons of the signal.", "Both processes provide a modulated signal to produce a multivariate chemical image in real-time with enhanced contrast to assist surgeons with delicate medical procedures.", "The embodiments contained herein can further be configured to provide real-time images displayed in stereo vision.", "Such a configuration would be apparent to those of skill in the art in view of this disclosure.", "Stereo vision further assists a surgeon by providing the depth perception needed in medical procedures employing medical imaging techniques, such as in endoscopic procedures.", "Systems and methods recited herein provide exemplary embodiments of the instant disclosure and are not intended to limit the disclosure to any particular embodiment.", "In the following illustrated embodiments, like reference characters refer to like parts.", "Modulating Collected Optical Signal The following embodiment features modulating an optical signal after the collection of photons that have interacted with a sample.", "System Having Conformal Filters in a Dual Polarization Arrangement: Referring now to FIG.", "1, a biological sample 100 may be illuminated and/or excited by an illumination source 103.In one embodiment, the illumination source 103 may comprise a quartz tungsten halogen light source.", "In other embodiments, the illumination source may comprise a metal halide light source, a light emitting diode (LED), a LED array having a uniform selection of emitters which emit over a constant wavelength range or a plurality of emitters which emit over a diversity of wavelength ranges, a pulsed LED, a pulsed LED array, a laser, a pulsed laser, a broadband illumination source and/or the like.", "The illumination source 103 generates illuminating photons that are directed from the illumination source 103 to the distal end of an endoscope 102 through a fiber optic bundle 104.The endoscope 102 is configured to direct interacted photons 101 that have interacted with the biological sample 100 to a polarizing beam splitter 107.Two independently tunable conformal filters 105a, 105b are situated along distinct orthogonal beam paths to filter orthogonal polarization components emerging from polarizing beam splitter 107.Suitable conformal filters for use in the instant disclosure may include those disclosed in U.S. Patent Application Publication Number 2013/0176568 to Priore et al., filed Jan. 4, 2013, assigned to Chemimage Corporation and entitled CONFORMAL FILTER AND METHOD OF USE THEREOF, the entirety of which is hereby incorporated by reference.", "In this arrangement, the paths of the filtered beams are not parallel through the conformal filters 105a, 105b, but are directed by appropriate reflectors, i.e., mirrors, 109a, 109b to a beam combiner 111.In alternate embodiments, the beam combiner may be a polarizing cube or polarizing beam splitter.", "In another embodiment, the orthogonal components may comprise the same or different multi-passband wavelengths Σλ1 and Σλ2.In the exemplary embodiment, the conformal filter 105a is configured to generate a polarized multi-passband wavelengths Σλ1 and conformal filter 105b is configured to generate a polarized multi-passband wavelengths Σλ2.In the exemplary embodiment, multi-passband wavelengths Σλ1 and Σλ2 are directed to a detector 115 through a lens assembly (not shown).", "In another embodiment, the multi-passband wavelengths Σλ1 and Σλ2 may be combined as they are directed to the detector 115.In some embodiments, beam paths from the polarizing beam splitter 107 to the beam combiner 111 may be made symmetrical to avoid, for example, a need for infinitely-corrected optics.", "The detector 115 as illustrated comprises a CCD detector.", "However, the present disclosure contemplates that the detector 115 may comprise other suitable detectors including, for example, a complementary metal-oxide-semiconductor, a (CMOS) detector, an indium gallium arsenide (InGaAs) detector, a platinum silicide (PtSi) detector, an indium antimonide (“InSb”) detector, a mercury cadmium telluride (“HgCdTe”) detector, or combinations thereof.", "Still referring to FIG.", "1, the two conformal filters 105a and 105b may be tuned in unison to the same multi-passband wavelengths (Σλ1=Σλ2) using an controller 117.In another embodiment, the controller 117 may be configured to independently tune each multi-passband wavelengths Σλ1 and Σλ2 to respectively process orthogonal components of the input.", "Therefore, by appropriate control, the conformal filters 105a and 105b may be tuned to the same multi-passband wavelengths or to two different multi-passband wavelengths (Σλ1≠Σλ2) at the same time.", "The controller 117 may be programmable or software-implemented to allow a user to selectively tune each conformal filter as desired.", "In the embodiment of FIG.", "1, a fast switching mechanism (not shown) may be provided to switch between the two views (or spectral images) corresponding to spectral data collected by the detector 117 from each of the conformal filters 105a and 105b.", "Alternatively, two such spectral views or images may be combined or overlaid into a single image to increase contrast or intensity, or for the purpose of comparison.", "The exemplary embodiment in FIG.", "1 comprises a single CCD detector 115 to capture the filtered signals received from the conformal filters 105a and 105b.", "FIG.", "1B illustrates an alternative embodiment of the instant disclosure.", "In this embodiment, the beam combiner 111 and mirror 109a may be removed and two detectors may be used.", "The first conformal filter 105a is configured to filter and transmit first multi-passband wavelengths corresponding to a T1 state to a first detector 115a where the first detector 115a detects the first multi-passband wavelengths and generates a first image data set (T1).", "In similar fashion, the second conformal filter 105b is configured to filter and transmit second multi-passband wavelengths corresponding to a T2 state to a second detector 115b where the second detector 115b detects the second multi-passband wavelengths and generate a second image data set (T2).", "U.S. Patent Application Publication Number 2014/0198315 to Treado et al., filed Jan. 15, 2014 assigned to Chemimage Corporation and entitled SYSTEM AND METHOD FOR ASSESSING ANALYTES USING CONFORMAL FILTERS AND DUAL POLARIZATION discloses the use of conformal filters in a dual polarization configuration as discussed above.", "The reference is hereby incorporated by reference in its entirety.", "FIG.", "1A illustrates an end-on view of the distal end of the endoscope 102.The distal end features a lens 119 for collecting interacted photons 101 and fiber ends 121 of the fiber optic bundle 103 which illuminate the biological sample 100 to generate the interacted photons 101.The detector 115 detects the multi-passband wavelength from the conformal filters 105a and 105b and is configured to generate one or more image data sets.", "The image data set may comprise a T1 image corresponding to the first multi-passband wavelengths Σλ1 and a T2 image corresponding to the second multi-passband wavelengths Σλ2.In one embodiment, the image data set comprises a Raman image data set.", "The one or more image data sets generated by the detector 115 may be further analyzed as set forth below.", "System Having MOE Filter Arrangements FIG.", "2 illustrates another embodiment featuring modulating the collected optical signal.", "In FIG.", "2, an illumination source 103 generates illuminating photons which traverse along a fiber optic bundle 104 through an endoscope 102 and terminate at a series of fiber ends 121 on the distal end of the endoscope 102 (shown in FIG.", "2A).", "The fiber ends 121 emit illuminating photons to illuminate a sample 100 to produce a plurality of interacted photons 101.The interacted photons are collected by a first collection optic 231 and a second collection optic 233.The first collection optic 231 collects a first portion of the interacted photons 101 and passes these photons on to a first Multivariate Optical Element “MOE” filter 237 which filters the first portion of the interacted photons 101 to generate a first portion of filtered photons.", "The first portion of filtered photons is detected by a first detector 241.Further, the second collection optic 233 collects a second portion of the interacted photons 101 and passes these photons on to a second MOE filter 238 to generate a second portion of filtered photons.", "The second portion of filtered photons is detected by a second detector 239.In one embodiment, the first detector 239 and the second detector 241 are CCD detectors.", "In other embodiments, the detectors 239 and 241 may comprise other suitable detectors including, for example, a complementary metal-oxide-semiconductor, a (CMOS) detector, an indium gallium arsenide (InGaAs) detector, a platinum silicide (PtSi) detector, an indium antimonide (“InSb”) detector, a mercury cadmium telluride (“HgCdTe”) detector, or combinations thereof.", "In one embodiment, the first MOE filter 237 may be configured to generate a first filtered passband.", "In one embodiment, the first MOE filter 237 is configured to generate a first filtered passband consistent with a randomized target or background.", "In one embodiment, the second MOE filter 238 may be configured to generate a second filtered passband consistent with the target or sample 100.In embodiments where the first MOE filter 231 is configured to generate a first filtered passband corresponding to a randomized target or background, the second MOE filter 238 may be configured to generate a second filtered passband corresponding to a target or sample.", "This type of embodiment permits discrimination of both a target and a background.", "MOEs are typically known in the art.", "An MOE features wide-band, optical interference filters encoded with an application-specific regression (or pattern) specific to a target.", "MOEs provide multivariate optical computing by performing the optical computation based on the pattern of the filter.", "In other words, MOEs are uniquely tuned to the pattern that needs to be measured using multivariate analysis on the filter as opposed to capturing multiple measurements at different wavelengths to estimate the full spectrum of a target and processing this information by applying multivariate statistics to the spectrum.", "Thus, MOEs increase throughput and efficiency over conventional filters, which can increase the speed of analysis.", "Suitable MOEs would be apparent to those of skill in the art in view of this disclosure.", "The first detector 241 is configured to detect the first filtered passband from the first MOE filter 237 to generate a first image data set (T1), and the second detector 239 is configured to detect the second filtered passband from the second MOE filter 238 to generate a second image data set (T2).", "The first image data set and the second image data set may be further analyzed, as set forth below.", "Modulating Illumination Source Signal The following embodiments feature modulating the illumination source signal prior to interaction with a sample.", "System Having a Conformal Filter Arrangement FIG.", "3 illustrates an illumination source 103 configured to generate illuminating photons which are transmitted through a filter 305.In one embodiment, the filter 305 comprises a conformal filter, as disclosed herein.", "In another embodiment, the filter 305 may comprise other filters, such as a liquid crystal tunable filter (“LCTF”), or filters as would be apparent to those of skill in the art in view of this disclosure.", "In one embodiment, the filter 305 may include a multi-conjugate filter.", "The filter 305 is controlled by a controller (not shown) that is configured to switch the filter configuration to pass first multi-passband wavelengths (Σλ1) and subsequently be switched to configure the filter to pass a second multi-passband wavelengths (Σλ2).", "In one embodiment, the rate at which the controller switches between the two states is on a millisecond order of magnitude.", "The filter 305 transmits each multi-passband wavelengths, Σλ1 and Σλ2, through a fiber optic bundle 309 to the distal end of an endoscope 102 where each multi-passband wavelengths exits the distal end of the endoscope 102 via fiber ends 321, as shown in FIG.", "3A, to illuminate the sample 100 and produce interacted photons 329.The interacted photons 329 are collected by a first detector 331 and a second detector 335 located on the distal end of the endoscope 102.The detectors 331 and 335 of the illustrated embodiment comprise CCD detectors.", "However, other detectors, such as disclosed herein, may be employed.", "The first detector 331 may be configured to detect substantially only the first multi-passband wavelengths.", "In one embodiment, the first detector 331 may be timed, i.e., turned off and on, to detect the first multi-passband wavelengths concurrent with the filter 305 transmitting the first multi-passband wavelengths.", "Likewise, the second detector 335 may be configured to detect substantially only the second multi-passband wavelengths.", "In one embodiment, the second detector 335 may be timed, i.e., turned off and on, to detect the second multi-passband wavelengths concurrent with the filter 305 transmitting the second multi-passband wavelengths.", "In another embodiment, the timing sequence of the modulation between the first multi-passband wavelengths and the second multi-passband wavelengths and the detection of the first multi-passband wavelengths and the second multi-passband wavelengths with the corresponding detector may be controlled by the controller (not shown).", "The first detector 231 detects the first multi-passband wavelengths and generates a first image data set (T1) and the second detector detects the second multi-passband wavelengths and generates a second image data set (T2).", "In one embodiment, the first image data set and the second image data set may be further analyzed as set forth below.", "System Having a Conformal Filters in Dual Polarization Arrangement FIG.", "4 illustrates another embodiment of illumination source modulation.", "In this embodiment, an illumination source 103 generates an optical signal that is transmitted through a polarizing beam splitter 405 which splits the optical signal into a first polarization signal and a second polarization signal.", "The first polarization signal is transmitted to a first filter 409, and the second polarization signal is transmitted to a second filter 411.In one embodiment, the first filter 409 and the second filter 411 each comprise conformal filter, as described herein.", "In another embodiment, the first filter 409 and second filter 411 comprise an LCTF.", "In one embodiment, the first filter 409 and the second filter 411 each may comprise a multi-conjugate filter.", "The first filter 409 is configured to filter the first polarization signal and transmit a first multi-passband wavelengths (Σλ1), and the second filter 411 is configured to filter the second polarization signal and transmit second multi-passband wavelengths (Σλ2).", "The first multi-passband wavelengths and the second multi-passband wavelengths are transmitted from their respective filters 409, 411 to the distal end of an endoscope 102 via a first fiber optic bundle 417 and second fiber optic bundle 419.In one embodiment, the first fiber optic bundle 417 and the second fiber optic bundle 419 comprise a polarization-maintaining fiber optic bundle.", "FIG.", "4A and FIG.", "4B illustrate different embodiments of the distal end of the endoscope 102.The first fiber bundle 417 and a the second fiber bundle 419 traverse through the endoscope 102 to the distal end.", "The first fiber bundle 417 terminates at first fiber ends 423 and the second fiber bundle 417 terminates at second fiber ends 425.FIG.", "4A illustrates one exemplary arrangement of the first fiber ends 423 with respect to the second fiber ends 425.In this embodiment, the first fiber ends 423 are distributed together on one side of the distal end of the endoscope 102 and the second fiber ends 425 are distributed together on the other side of the distal end of the endoscope 102.In FIG.", "4B, another embodiment is shown where the first fiber ends 423 and the second fiber ends 425 alternate around the distal end of the endoscope 102.Suitable arrangements of the fiber ends would be apparent to those of skill in the art in view of this disclosure.", "The sample 100 is illuminated from the multi-first passband wavelengths and the second multi-passband wavelengths emitting from the first fiber ends 423 and the second fiber ends 425, respectively, to generate interacted photons 435.The interacted photons 435 are detected by a first detector 437 and a second detector 441 disposed on the distal end of the endoscope 102.In the illustrated embodiment, the first detector 437 and the second detector 441 are CCD detectors.", "However, other suitable detectors, such as those disclosed herein, may be employed and such detectors would be apparent to one of skill in the art in view of this disclosure.", "In one embodiment, the first fiber bundle 417 and the second fiber bundle 419 comprise polarization maintaining fiber bundles.", "In such an embodiment, polarizers (not shown) may be disposed in front of the detectors 437 and 441, which are arranged for stereovision, and configured to differentiate between a T1 state and a T2 state on the basis of polarization.", "In one embodiment, the first detector 437 is configured to detect substantially only interacted photons generated from the first multi-passband wavelengths, and the second detector 441 is configured to detect substantially only interacted photons generated from the second multi-passband wavelengths.", "As such, the location of the first fiber ends 423 and second fiber ends 425 with respect to the first detector 437 and the second detector 441 can be arranged to optimize the detection of the interacted photons corresponding to the first multi-passband wavelengths by the first detector 437 and the interacted photons corresponding to second multi-passband wavelengths by the second detector 441.Once the first detector 437 and the second detector 441 detect the interacted photons 435, the first detector 437 is configured to generate a first image data set (T1), and the second detector 441 is configured to generate a second image data set (T2).", "In one embodiment, the first image data set and the second image data set may be further analyzed.", "System Having an Acousto-Optic Filter Arrangement FIG.", "5 illustrates an embodiment of the instant disclosure employing an acousto-optic tunable filter (AOTF).", "This embodiment features an illumination source 103 to generate illuminating photons for illuminating a sample 100.A filter 507 is configured to filter photons emitted from the illumination source 103.In one embodiment, the filter 507 comprises an AOTF in which the AOTF transmits a single passband wavelength.", "To achieve a >10 fps sampling rate, the AOTF is rapidly switched between target vs background passband wavelengths.", "In another embodiment, the filter comprises a conformal filter based on AOTF technology in which the AOTF transmits multi-passband wavelengths simultaneously.", "To switch between T1 and T2 states, the conformal filter AOTF is switched in series with microsecond switching speeds.", "In other embodiments, multiple conformal AOTFs may be employed in which the T1 and T2 states are selected simultaneously.", "In embodiments employing multiple acousto-optic filters, each filter may be tuned to various wavelengths where each filter transmits different multi-passband wavelengths simultaneously.", "Acousto-optic filters are known in the art and, generally, operate by passing a beam of source light through a substrate, typically quartz.", "The substrate is vibrated by a piezoelectric transducer modulator.", "An RF frequency is applied to the modulator, causing the substrate to vibrate.", "Source light or radiation is passed through the vibrating substrate, which causes the source light passing through the substrate to diffract, thus creating a filter gradient for the source light.", "The source light emitted from the acousto-optic filter can be filtered to a desired passband wavelength by the RF frequency applied to the piezoelectric transducer.", "Details on the operation of an acousto-optic filter are described in more detail in Turner, John F. and Treado, Patrick J.", "“Near-Infrared Acousto-Optic Tunable Filter Hadamard Transform Spectroscopy” Applied Spectroscopy, 50.2 (1996), 277-284, which is hereby incorporated by reference in its entirety.", "The passband wavelength transmitted from the filter 507 is transmitted to the distal end of an endoscope 102 through a fiber optic bundle 515.FIG.", "5A illustrates the distal end of the endoscope 102 and features a plurality of fiber ends 519 from the fiber optic bundle 515.The fiber ends 519 transmit the passband wavelength from the filter 507 to illuminate the sample 100 to produce interacted photons 521 which are detected by a first detector 525 and a second detector 529 located on the distal end of the endoscope 102.In one embodiment, only one detector is used, i.e., the first detector 525, to detect a plurality of the interacted photons 521.In another embodiment, the interacted photons 521 are detected by both detectors 525 and 529.In another embodiment, a plurality of acousto-optic filters are employed and generate a first passband wavelength and a second passband wavelength.", "The first detector 525 may be configured to detect the first passband wavelength and generate a first image data set (T1), and the second detector 529 may be configured to detect the second passband wavelength and generate a second image data set (T2).", "In one embodiment, the first image data set and the second image data set may be further analyzed as set forth below.", "System Having an MOE Filter Wheel Arrangement FIG.", "6 illustrates another embodiment according to the instant disclosure.", "An illumination source 103 generates illuminating photons which are transmitted to a filter wheel 605 where the illuminating photons are filtered to generate filtered photons.", "The filter wheel 605 comprises a plurality of filter elements 609.In one embodiment, each filter element 605 comprises an MOE.", "Suitable MOEs for use in the instant disclosure are known in the art and described herein.", "Each filter element 609 may be different and each filter element may be configured to filter and transmit a different passband wavelength.", "For example, filter element 609a may be configured to transmit a wavelength corresponding to a background, such as a specific type of tissue or anatomical structure, and filter element 609b may be configured to transmit a passband wavelength corresponding to an anomaly in a tissue sample, such as a cancerous tumor on the tissue.", "In this type of embodiment, the filter wheel 605 can be rotated during a surgical procedure to assist a surgeon in distinguishing normal tissue from cancerous tissue.", "In another embodiment, the filter elements 609 are configured to detect a plurality of different samples.", "In one embodiment, the filter elements 609 are configured to discriminate background tissue from an anatomical structure such as a ureter.", "The filtered photons are transmitted via a fiber optic bundle 603 to the distal end of the endoscope 102 and exit the distal end of the endoscope through a plurality of fiber ends 621 as shown in FIG.", "6A.", "The filtered photons illuminate the sample 100 and generate a plurality of interacted photons 601.The interacted photons 601 are detected by a one or more detectors 619, and the one or more detectors 619 is configured to generate an image data set (T1).", "In one embodiment, the image data set may be further analyzed, as set forth below.", "System Having a Patterned Etalon Filter Arrangement FIG.", "7 illustrates another embodiment of the instant disclosure.", "Illumination source 103 generates illuminating photons which are transmitted through a fiber optic bundle 104 to the distal end of the endoscope 102 to fiber ends 121.Illuminating photons exit the fiber ends 121 and illuminate the sample 100 and generate interacted photons 101 from the sample 100.The interacted photons 101 are detected by a first detector 705 and a second detector 707 disposed on the distal end of the endoscope 102.In one embodiment, the first detector 705 and the second detector 707 comprise hyperspectral cameras.", "In one embodiment, the detectors 705 and 707 comprise a Fabry-Perot interferometric (patterned etalon) filter configuration disposed on each pixel of the detector.", "Suitable examples of patterned etalon filter arrangements and associated detectors are available from Ximea Corporation.", "The filter on each pixel is configured to transmit one or more passband wavelengths for each pixel.", "In one embodiment, the first detector 705 comprises a patterned etalon filter arrangement in a mosaic snapshot arrangement.", "A mosaic snapshot can be acquired over 1088×2048 pixels.", "In one embodiment, the mosaic snapshot comprises a 4×4 mosaic having 16 wavelength bands.", "In another embodiment, the mosaic snapshot comprises a snapshot of the sample from 465-630 nm at 11 nm intervals.", "In another embodiment, the mosaic snapshot may comprise a 5×5 mosaic having 25 bands over a wavelength range from about 600 to 1,000 nm.", "The mosaic snapshot may include a spatial resolution per band of about 512×272 with up to 2 megapixels with interpolation and may collect up to 170 data-cubes/sec.", "In another embodiment, the first detector 705 and the second detector 707 may comprise a patterned etalon filter arrangement for obtaining a snapshot tiled configuration.", "In one embodiment, the snapshot tiled configuration transmits a passband wavelength at each pixel.", "The patterned etalon snapshot tiled filter configuration can acquire up to 1088×2048 pixels.", "In one embodiment, the tiled snapshot has a spectral resolution of up to 32 bands and can detect wavelengths ranging from 600-1,000 nm over 12 incremental steps.", "In another embodiment, the spatial resolution per band is about 256×256.In another embodiment, the tiled snapshot may detect up to 170 data-cubes/sec.", "The patterned etalon filter arrangement may also be customized to generate a predetermined response based on the sample to be analyzed and the result desired.", "Such customization would be apparent to one of skill in the art in view of this disclosure.", "In one embodiment, the first detector 705 and the second detector 707 comprise IMEC mosaic filter arrangements.", "In such an embodiment, the patterned etalon mosaic filter arrangements of the first detector 705 and the second detector 707 are configured to transmit one or more different wavelength bands at each pixel.", "In another embodiment, the first detector 705 and the second detector 707 comprise patterned etalon tiled filter arrangements.", "In such an embodiment, the patterned etalon tiled filter arrangements of the first detector 705 and the second detector 707 are configured to detect a different wavelength band at each pixel.", "In another embodiment, the second detector is eliminated and the embodiment employs the first detector 705 having either a snapshot mosaic patterned etalon filter arrangement or a snapshot tiled patterned etalon filter arrangement.", "The detectors 705 and 707 are configured to generate one or more image data sets for each passband wavelength transmitted from the filter arrangements.", "In one embodiment, the detectors 705 and 707 are configured to generate a first image data set (T1) and a second image data set (T2).", "In one embodiment, the image data sets may be further analyzed, as set forth below.", "In yet another embodiment, an illumination source may be configured to generate illuminating photons at specific wavelengths.", "For example, the illumination source may comprise a plurality of LEDs where a first portion of the LEDs are configured to generate a first wavelength and a second portion of the LEDs are configured to generate a second wavelength for illuminating a sample.", "In such an embodiment, a first detector may be configured to detect interacted photons from the first wavelength and generate a first image data set (T1), and a second detector may be configured to detect interacted photons from the second wavelength and generate a second image data set (T2).", "Other illumination sources or arrangements may be employed which are capable of producing illuminating photons at a plurality of wavelengths.", "In one embodiment, the illumination source comprises a modulating laser which is capable of generating multiple wavelengths.", "The image data sets described herein may comprise one or more of an ultraviolet (UV) image data set, fluorescence image data set, a visible (VIS) image data set, a Raman image data set, a near-infrared (NIR) image data set, a short-wave infrared (SWIR) data set, a mid-infrared (MIR) data set, and a long-wave infrared (LWIR) data set.", "In another embodiment, the image data set comprises a hyperspectral image data set.", "The image data sets of the instant disclosure may further be analyzed.", "In one embodiment, the systems disclosed herein may include a fiber array spectral translator (FAST).", "Suitable FAST devices are disclosed in U.S. Pat.", "No.", "8,098,373 to Nelson et al., entitled SPATIALLY AND SPECTRALLY PARALLELIZED FIBER ARRAY SPECTRAL TRANSLATOR SYSTEM AND METHOD OF USE, filed Apr.", "13, 2010 and assigned to Chemimage Corporation, the disclosure of which is incorporated by reference in its entirety.", "In one embodiment, the systems disclosed herein may comprise a processor and a non-transitory processor-readable storage medium in operable communication with the processor.", "The storage medium may contain one or more programming instructions that, when executed, cause the processor to analyze the image data sets.", "In one embodiment, the analysis may comprise applying an optical computation to the data set.", "In another embodiment, the optical computation may comprise one or more of T1, and (T1-T2)/(T1+T2).", "Other optical computations known in the art may be applied.", "In one embodiment, the analysis may comprise applying one or more chemometric techniques to the image data sets.", "The chemometric analysis may comprise one or more of a multivariate curve resolution analysis, a principle component analysis (PCA), a partial least squares discriminant analysis (PLSDA), a k means clustering analysis, a band t entropy analysis, an adaptive subspace detector analysis, a cosine correlation analysis, a Euclidian distance analysis, a partial least squares regression analysis, a spectral mixture resolution analysis, a spectral angle mapper metric analysis, a spectral information divergence metric analysis, a Mahalanobis distance metric analysis, and spectral unmixing analysis.", "In some embodiments, the processor may be configured to control operation of the system.", "For example, in embodiments where a tunable filter is employed, the process may be configured to cause the a controller to apply voltages to the tunable filter to obtain the desired passband transmission.", "Further, the processor may be configured to control timing of an illumination source and detectors so that the correct detector is in operation for the specific illumination.", "Other processor configurations are contemplated and would be apparent to one of skill in the art in view of this disclosure.", "The systems according to the instant disclosure may further include a display.", "In some embodiments, the display may include one or more results from one or more of the detectors.", "In another embodiment, the display may include one or more results from the analysis of the processor.", "In one embodiment, the display may include one or more results from one or more of the detectors and one or more results from the analysis of the processor." ] ]
Patent_15932435
[ [ "TOURNIQUET", "A tourniquet with two locking, two release and two tension mechanisms that occludes blood flow in extremities, but can also be used as a pressure strap to hold gauze over wounds on different part of the body including torso." ], [ "1.-23.", "(canceled) 24.A tourniquet with two locking, two release and two tension mechanisms that occludes blood flow in extremities, but can also be used as a pressure strap to hold gauze over wounds on different part of the body including torso.", "25.The tourniquet of claim 24, including: a first locking and tension mechanism comprising a strap that has serrated teeth all along the length of the strap; a head that has an automatic locking mechanism in the form of teeth that interlock with teeth on the strap; a second locking and tension mechanism comprising: a tension bar, a buckle, and a windlass locking mechanism.", "26.The tourniquet of claim 25, wherein the strap with serrated teeth is attached to a plastic plate that also has attached to it a buckle and clips that hold a windlass rod.", "27.The tourniquet of claim 26, wherein the buckle is attached to another buckle by fabric material which then the fabric material is threaded into a plastic plate to give support to locking mechanism, the fabric material passes through the tension bar, and the other end of material is attached to another buckle that attaches to the locking head of the automatic locking mechanism.", "28.The tourniquet of claim 27, wherein the fabric material is also attached to a tension bar when the tension bar is twisted it draws inward the fabric material and the strap causing more circumference pressure around the object or extremities which causes occlusion of blood flow, so that the more the tension bar is twisted the tighter the tourniquet becomes around the limb.", "29.The tourniquet of claim 25, wherein attached to the buckle are two clip mechanisms to store tension rod.", "30.The tourniquet of claim 24, wherein the tourniquet has a double locking mechanism first locking mechanism is the interlocking of strap teeth with the teeth in head, the second is a windlass mechanism, both are used to tighten tourniquet pressure around limb to occlude blood flow.", "31.The tourniquet of claim 24, wherein the end of strap (tail) has a liquid timer strip; it automatically activated when reservoir of timer is ruptured when it passes through mouth of head, it can also be activated by manually pressing down on reservoir with finger, and the timer informs user the length of time the tourniquet has been on.", "32.The tourniquet of claim 24, wherein the tourniquet can also be used as a tactical tool to bound limbs and carry equipment.", "33.The tourniquet of claim 24, wherein the tourniquet is equipped with a body sensor that can read vital signs of body temperature, blood pressure, heart rate, and oxygen level, and the device can also detect if a victim is going into shock from loss of blood.", "34.The tourniquet of claim 24, wherein the tourniquet is equipped with a transceiver and GPS receiver that can transmit victim's voice and vital signs to a remote location.", "35.The tourniquet of claim 24, wherein the tourniquet strap is constructed so two tourniquets can be connected together to form one larger tourniquet.", "36.The tourniquet of claim 24, wherein the strap has a chemical patch attached to it, which can be self-activated by the victim; the patch can be, but not limited to morphine lanacane etc.", "for relief of tourniquet pain or from wound.", "37.The tourniquet of claim 24, the tourniquet has a visible light or infrared light so it can only be visible with infrared device.", "38.The tourniquet of claim 24, wherein the tourniquet can be stored and packaged in a ready to deploy position, which allows the user to remove tourniquet from packaging using only one hand and slipping the tourniquet on to the limb and tightening, this is accomplished by storing tourniquet tail into mouth of locking head.", "39.The tourniquet of claim 24, wherein the teeth on strap are distanced in millimeters which allows for slight tension adjustment, for partial or full occlusion, also eliminates over tightening that causes pain and possible broken bones.", "40.The tourniquet of claim 24, wherein the material used for strap, is bullet, oil, dirt, water resistant and self-sealing.", "41.The tourniquet of claim 24, wherein two tourniquets can be connected together to make one larger tourniquet to be used on torso area to hold pressure dressings or to hold in place fractured hip, to use as a junction tourniquet.", "42.The tourniquet of claim 24, wherein built into the locking head mechanism is a one finger safety release lever to disengage locking teeth in head with teeth on strap and release of pressure.", "43.The tourniquet of claim 24, wherein the tourniquet has a UV inhibitor." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>The present invention is directed to tourniquets, and, more particularly, to tourniquets with a windlass tightening mechanism and other accessories.", "We now live in a post 911 environment in a World where violent threats and terrorist attacks are literally knocking at our door; school mass shooting, bombings, vehicle attacks is the reality of today.", "These attacks cause trauma wounds and hemorrhaging to the extremities and in some cases loss of limb if not immediately treated, the victim will die from blood loss within 90 seconds to 5 minutes.", "The White House and Homeland Security has begun a campaign called “Stop the Bleed” it calls for Worldwide distribution of tourniquets to be placed in school, vehicles, first responders, office buildings, airports, stadiums, outdoor events, all law enforcement and everywhere there are first aid kits and defibrillators.", "The current tourniquet in use today require prior training in order to apply properly, the current application time is at least 5 minutes, a tourniquet is needed that anyone can apply within a few seconds, a tourniquet that a bystander can apply to a victim without prior training, because no matter how fast a first responder arrives, the bystander will always be first on the scene.", "The current invention is the first tourniquet that can be applied within seconds; its familiar design similar to a zip tie, allows almost anyone to be able to apply it.", "Its water, oil and temperature resistant, it's been tested and approved by Homeland Security and first responders.", "It's also the first tourniquet that has an automatic timer that informs first responders how long the tourniquet was applied to help prevent tissue and muscle damage.", "A windlass tightening mechanism is described in U.S. Pat.", "No.", "7,842,067 see Esposito Nov. 30, 2010.In accordance with the present invention, Esposito tourniquet has an inner strap, that the windlass tension bar pulls in and tightens tourniquet.", "Esposito also uses fabric material for the tourniquet strap FIG.", "2 # 14 , line 26 “pull the inner strap” as other prior art, the tourniquet strap when made with Velcro which will fail if the Velcro becomes wet, dirty or is exposed to oil, also Velcro is not resistant to high heat or extreme cold.", "Rex McDonald U.S. Pat.", "No.", "8,926,651B2 describes a Windlass Tourniquet that also uses Velcro as a strap." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present invention has the following features that make it unique: Has a double locking and tension mechanism.", "The S.T.A.T.", "Tourniquet is designed to interlock with 2 or more extra tourniquets to form one large tourniquet that can be used on the torso to hold pressure on gauze over wound forming a pressure strap.", "S.T.A.T.", "Tourniquet pressure strap can support fractured hips, skull fractures, or to help occlude abdominal bleeding.", "Can be worn on Molle compatible gear.", "Self-activating liquid timing strip.", "2 tension release levers." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application claims benefit under 35 U.S.C.", "§ 119(e) to Provisional Application Ser.", "Nos.", "62/496,016, filed on Oct. 3, 2016; 62/496,017, filed on Oct. 3, 2016; and 62/496,018, filed on Oct. 3, 2016, the disclosures of which are incorporated herein by reference in their entireties.", "BACKGROUND OF THE INVENTION The present invention is directed to tourniquets, and, more particularly, to tourniquets with a windlass tightening mechanism and other accessories.", "We now live in a post 911 environment in a World where violent threats and terrorist attacks are literally knocking at our door; school mass shooting, bombings, vehicle attacks is the reality of today.", "These attacks cause trauma wounds and hemorrhaging to the extremities and in some cases loss of limb if not immediately treated, the victim will die from blood loss within 90 seconds to 5 minutes.", "The White House and Homeland Security has begun a campaign called “Stop the Bleed” it calls for Worldwide distribution of tourniquets to be placed in school, vehicles, first responders, office buildings, airports, stadiums, outdoor events, all law enforcement and everywhere there are first aid kits and defibrillators.", "The current tourniquet in use today require prior training in order to apply properly, the current application time is at least 5 minutes, a tourniquet is needed that anyone can apply within a few seconds, a tourniquet that a bystander can apply to a victim without prior training, because no matter how fast a first responder arrives, the bystander will always be first on the scene.", "The current invention is the first tourniquet that can be applied within seconds; its familiar design similar to a zip tie, allows almost anyone to be able to apply it.", "Its water, oil and temperature resistant, it's been tested and approved by Homeland Security and first responders.", "It's also the first tourniquet that has an automatic timer that informs first responders how long the tourniquet was applied to help prevent tissue and muscle damage.", "A windlass tightening mechanism is described in U.S. Pat.", "No.", "7,842,067 see Esposito Nov. 30, 2010.In accordance with the present invention, Esposito tourniquet has an inner strap, that the windlass tension bar pulls in and tightens tourniquet.", "Esposito also uses fabric material for the tourniquet strap FIG.", "2 #14, line 26 “pull the inner strap” as other prior art, the tourniquet strap when made with Velcro which will fail if the Velcro becomes wet, dirty or is exposed to oil, also Velcro is not resistant to high heat or extreme cold.", "Rex McDonald U.S. Pat.", "No.", "8,926,651B2 describes a Windlass Tourniquet that also uses Velcro as a strap.", "SUMMARY OF THE INVENTION The present invention has the following features that make it unique: Has a double locking and tension mechanism.", "The S.T.A.T.", "Tourniquet is designed to interlock with 2 or more extra tourniquets to form one large tourniquet that can be used on the torso to hold pressure on gauze over wound forming a pressure strap.", "S.T.A.T.", "Tourniquet pressure strap can support fractured hips, skull fractures, or to help occlude abdominal bleeding.", "Can be worn on Molle compatible gear.", "Self-activating liquid timing strip.", "2 tension release levers.", "BRIEF DESCRIPTION OF THE DRAWING(S) FIG.", "1 is a perspective of a tourniquet in accordance with the present invention.", "FIG.", "2 shows one side of the strap component of the tourniquet of FIG.", "1.FIG.", "3 is another perspective of the tourniquet of FIG.", "1 with the leading edge folded over.", "FIG.", "4 is another perspective of the tourniquet of FIG.", "1, showing its initial insertion into the head component.", "FIG.", "5 is a perspective of the windlass tensioning mechanism of the tourniquet of FIG.", "1.FIG.", "6 shows a cross section through the head component of the tourniquet of FIG.", "1.FIG.", "7 shows a side view of the tourniquet of FIG.", "1.FIG.", "8 shows another perspective of the tourniquet of FIG.", "1.FIG.", "9 shows a top view of the tourniquet of FIG.", "1.Other features and advantages of the present invention will become apparent from the following description of the invention which refers to the accompanying drawings.", "DETAILED DESCRIPTION OF EMBODIMENTS OF THE INVENTION In FIG.", "1: #101 is the Windlass Locking and tension assembly; #100 is the 2nd locking and tension adjustment head; #6 is the serrated strap of the tourniquet; #9 is the automatic timer; #10 is the finger hole; #11 is the tail of strap; #63 is the buckle that attaches to the strap and plastic plate #151; #61 is the fabric material that connects to Windlass rod #60; #62 are the clips that hold Windlass rod #60; #150 is the buckle that connects to #151 plastic plate and locking head #2; #12 is a protruding mechanism that holds extra strap slack, it also serves as a safety cover over #5 release cover; and #155 is the non-slip finger grips.", "In FIG.", "6: #2 is the locking head; #156 is the locking teeth that strap teeth interlock with; #5 is the release lever that disengages locking teeth in the head with strap teeth #7; #90 is where strap is inserted; #71 keeps strap #6 straight, so strap evenly locks with teeth #156; #12 is the protruding mechanism that holds extra slack of the strap; #90 is where strap #11 is inserted; and #14 sleeve that covers the Windlass locking mechanism.", "FIG.", "6 shows a side view of locking head #101.FIG.", "4 shows strap #6 entering the locking head #2.FIG.", "1 shows the Windlass mechanism #101 and locking head #100 assembly.", "FIG.", "2 shows the complete tourniquet laid flat and direction of tension bar turning.", "FIG.", "3 shows strap #6 in slack holder #12, it also shows the timer #9.FIGS.", "8, 9, and 7 show a different design tourniquet where there is a sleeve over windlass assembly #101.FIG.", "7 shows a side view of tourniquet with windlass sleeve #14.FIG.", "5 shows tourniquet with windlass sleeve #14 and fabric material inserted into windlass tension rod.", "The present invention eliminates the inner fabric and Velcro, and only tightens the plastic strap 6 FIG.", "1.In addition to the windlass tension mechanism.", "The present invention has a second tension mechanism to tighten the tourniquet, it uses male teeth in head 90 FIG.", "6 and interlocks with female teeth 7 on strap FIG.", "1, to interlock with each other; female teeth on strap are only half of a millimeter spacing allow for gradual increase in tension by pulling strap away from head increases tension, tension adjustments in millimeters eliminating over tightening which causes pain, and in some cases the victim (If a child) can break bones.", "The tourniquet is also able to ratchet it down to fit the circumference of children, or the elderly.", "In order to use the tourniquet, the strap is placed around the limb, the tail #11 of strap is inserted into #90 of locking head #2, the teeth #7 on strap interlock with teeth in the head #156 of FIG.", "6.Extra slack of the strap is placed into holder #12; ifs also used as a safety cover for #5 the release lever.", "In FIG.", "3 to increase circumference tension of strap around the limb, tail #11 is pulled away from the head.", "Should blood flow not stop then the Windlass rod #60 would be turned which would pull the fabric material #61 and strap #6 inward which would increase the tourniquet tension; once desired tension is accomplished, Windlass rod is stored in clip #62.In order to release tension wither the Windlass rod #60 is removed from clip #62 and unwound, or release lever #5 can be pulled backward to disengage the teeth on strap with teeth in the head.", "According to the present invention, when tourniquet strap teeth engage with teeth in the head an audible sound can be heard to verify tourniquet has been properly applied.", "According to the present invention, the locking head has a triple locking mechanism with teeth in the head that engage with teeth on the strap.", "According to the present invention, the strap is made of a plastic material, which is flexible and can withstand temperatures of below 0 degrees and up to 250 degrees Fahrenheit.", "Although the present invention has been described in relation to particular embodiments thereof, many other variations and modifications and other uses will become apparent to those skilled in the art.", "It is preferred, therefore, that the present invention be limited not by the specific disclosure herein, but only by the appended claims." ] ]
Patent_15932437