hcaoaf/MoleculeQA · Datasets at Hugging Face

text stringlengths 3 799
Option A: It can be used for the treatment and management of Parkinson's disease.
Option B: It can be used for the treatment of sickle cell disease, malaria, and some cancers.
Option C: It has been studied for the treatment of acute myeloid leukaemia, arthritis, and atherosclerotic plaque formation.
Option D: It can be used for the treatment of Lennox-Gastaut syndrome and Dravet syndrome.
" A
2206 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=O)N(N1C)C2=CC=CC=C2
Question about this molecule: How can the molecule be used for treatment
Option A: It can be used for the treatment of sickle cell disease, malaria, and some cancers.
Option B: It can be used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.
Option C: It can be used in the prevention of invasive fungal infections due to aspergillosis and candida in high-risk patients.
Option D: It is used to treat bacterial infections including bronchitis and urinary tract infections, and to prevent urinary tract infections prior to surgery.
" B
47472 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=C(C(=C1)Cl)SC(CCC2=CC=C(C=C2)Cl)CN3C=CN=C3)Cl
Question about this molecule: How can the molecule be used for treatment
Option A: It can be used in the treatment of status epilepticus.
Option B: It is used as a treatment for leishmaniasis.
Option C: It is used in the treatment of giardiasis and cholera.
Option D: It can be used in gynecology.
" D
5284616 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC
Question about this molecule: How can the molecule be used for treatment
Option A: It can be used as an antibacterial and antifungal agent.
Option B: It can be used as an antifungal antibiotic.
Option C: It is used as an antiseptic and antifungal agent.
Option D: It can be used as an immunosuppressive and antitumor agent.
" D
119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C(CC(=O)O)CN
Question about this molecule: How can the molecule be used for treatment
Option A: It is used as a treatment for leishmaniasis.
Option B: It can be used in the treatment of status epilepticus.
Option C: It is used in the treatment of giardiasis and cholera.
Option D: It can be used in the treatment of epilepsy and bipolar disorder.
" B
182137 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN[C@@]1(CCCCC1=O)C2=CC=CC=C2Cl
Question about this molecule: How can the molecule be used for treatment
Option A: It can be used for the treatment of treatment-resistant major depression.
Option B: It can be used for the treatment of major depression.
Option C: It can be used for the treatment of various diseases.
Option D: It can be used for the treatment of severe long-term depression.
" A
4189 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
Question about this molecule: How can the molecule be used for treatment
Option A: It is a prodrug for an antifungal agent used for the treatment of invasive aspergillosis and invasive mucormycosis.
Option B: It is used as a triazole antifungal with a broad spectrum of activity and good safety profile.
Option C: It is used in the prevention and treatment of a variety of fungal infections as an imidazole antifungal agent.
Option D: It can be used as a broad-spectrum azole antifungal with some activity against Gram-positive bacteria.
" D
5371562 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C/C(=C\\C(=O)NC)/OP(=O)(OC)OC
Question about this molecule: What is the right withdrawal information about this molecule?
Option A: It was withdrawn in 2000 due to the risk of hepatotoxicity.
Option B: It was withdrawn from the American market in 2000 due to its ability to cause serious adverse effects, including agranulocytosis.
Option C: It was withdrawn from use on potatoes and tomatoes in 1985.
Option D: It was withdrawn from the market by Elan Pharmaceuticals in 2001.
" C
2366 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CNCCC1=CC=CC=N1
Question about this molecule: What is the right withdrawal information about this molecule?
Option A: It was withdrawn from the American market in 2000 due to its ability to cause serious adverse effects, including agranulocytosis.
Option B: It was withdrawn within approximately 5 years of its first approval by the FDA in the 1970s due to a lack of evidence supporting its efficacy.
Option C: It was withdrawn in 1965 because of dissociative hallucinogenic effects that were often disturbing and sometimes severe and prolonged.
Option D: It was withdrawn from Canadian and U.S. markets in October 2010 due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease.
" B
5323 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: COC1=NC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N)OC
Question about this molecule: What is the right withdrawal information about this molecule?
Option A: It is one of the products that have been withdrawn or removed from the market in the US after being found to be unsafe or not effective.
Option B: It was withdrawn from Canadian and U.S. markets in October 2010 due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease.
Option C: It was withdrawn within approximately 5 years of its first approval by the FDA in the 1970s due to a lack of evidence supporting its efficacy.
Option D: It was withdrawn from the American market in 2000 due to its ability to cause serious adverse effects, including agranulocytosis.
" A
39941 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C1=CC2=C(C=C1)OC(=N2)C3=CC=C(C=C3)Cl)C(=O)O
Question about this molecule: What is the right withdrawn from market information about this molecule?
Option A: It was withdrawn from the market due to adverse side-effects including liver necrosis, photosensitivity, and carcinogenicity in animals.
Option B: It was withdrawn from the market in 1982 due to links with hepatitis.
Option C: It was withdrawn from the market following its association with cases of Stevens-Johnson syndrome.
Option D: It was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market.
" A
38409 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CSC(=C1)C(=O)C2=C(C(=C(C=C2)OCC(=O)O)Cl)Cl
Question about this molecule: What is the right withdrawn from market information about this molecule?
Option A: It was withdrawn from the market following suspicions of carcenogenicity.
Option B: It was withdrawn from the market following its association with cases of Stevens-Johnson syndrome.
Option C: It was withdrawn from the market due to causing severe gastrointestinal bleeding.
Option D: It was withdrawn from the market in 1982 due to links with hepatitis.
" D

Option A: It can be used for the treatment and management of Parkinson's disease.

Option B: It can be used for the treatment of sickle cell disease, malaria, and some cancers.

Option C: It has been studied for the treatment of acute myeloid leukaemia, arthritis, and atherosclerotic plaque formation.

Option D: It can be used for the treatment of Lennox-Gastaut syndrome and Dravet syndrome.

" A

2206 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC1=CC(=O)N(N1C)C2=CC=CC=C2

Question about this molecule: How can the molecule be used for treatment

Option A: It can be used for the treatment of sickle cell disease, malaria, and some cancers.

Option B: It can be used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.

Option C: It can be used in the prevention of invasive fungal infections due to aspergillosis and candida in high-risk patients.

Option D: It is used to treat bacterial infections including bronchitis and urinary tract infections, and to prevent urinary tract infections prior to surgery.

" B

47472 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C1=CC(=C(C(=C1)Cl)SC(CCC2=CC=C(C=C2)Cl)CN3C=CN=C3)Cl

Question about this molecule: How can the molecule be used for treatment

Option A: It can be used in the treatment of status epilepticus.

Option B: It is used as a treatment for leishmaniasis.

Option C: It is used in the treatment of giardiasis and cholera.

Option D: It can be used in gynecology.

" D

5284616 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC

Question about this molecule: How can the molecule be used for treatment

Option A: It can be used as an antibacterial and antifungal agent.

Option B: It can be used as an antifungal antibiotic.

Option C: It is used as an antiseptic and antifungal agent.

Option D: It can be used as an immunosuppressive and antitumor agent.

" D

119 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C(CC(=O)O)CN

Question about this molecule: How can the molecule be used for treatment

Option A: It is used as a treatment for leishmaniasis.

Option B: It can be used in the treatment of status epilepticus.

Option C: It is used in the treatment of giardiasis and cholera.

Option D: It can be used in the treatment of epilepsy and bipolar disorder.

" B

182137 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CN[C@@]1(CCCCC1=O)C2=CC=CC=C2Cl

Question about this molecule: How can the molecule be used for treatment

Option A: It can be used for the treatment of treatment-resistant major depression.

Option B: It can be used for the treatment of major depression.

Option C: It can be used for the treatment of various diseases.

Option D: It can be used for the treatment of severe long-term depression.

" A

4189 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl

Question about this molecule: How can the molecule be used for treatment

Option A: It is a prodrug for an antifungal agent used for the treatment of invasive aspergillosis and invasive mucormycosis.

Option B: It is used as a triazole antifungal with a broad spectrum of activity and good safety profile.

Option C: It is used in the prevention and treatment of a variety of fungal infections as an imidazole antifungal agent.

Option D: It can be used as a broad-spectrum azole antifungal with some activity against Gram-positive bacteria.

" D

5371562 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C/C(=C\\C(=O)NC)/OP(=O)(OC)OC

Question about this molecule: What is the right withdrawal information about this molecule?

Option A: It was withdrawn in 2000 due to the risk of hepatotoxicity.

Option B: It was withdrawn from the American market in 2000 due to its ability to cause serious adverse effects, including agranulocytosis.

Option C: It was withdrawn from use on potatoes and tomatoes in 1985.

Option D: It was withdrawn from the market by Elan Pharmaceuticals in 2001.

" C

2366 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CNCCC1=CC=CC=N1

Question about this molecule: What is the right withdrawal information about this molecule?

Option A: It was withdrawn from the American market in 2000 due to its ability to cause serious adverse effects, including agranulocytosis.

Option B: It was withdrawn within approximately 5 years of its first approval by the FDA in the 1970s due to a lack of evidence supporting its efficacy.

Option C: It was withdrawn in 1965 because of dissociative hallucinogenic effects that were often disturbing and sometimes severe and prolonged.

Option D: It was withdrawn from Canadian and U.S. markets in October 2010 due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease.

" B

5323 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: COC1=NC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N)OC

Question about this molecule: What is the right withdrawal information about this molecule?

Option A: It is one of the products that have been withdrawn or removed from the market in the US after being found to be unsafe or not effective.

Option B: It was withdrawn from Canadian and U.S. markets in October 2010 due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease.

Option C: It was withdrawn within approximately 5 years of its first approval by the FDA in the 1970s due to a lack of evidence supporting its efficacy.

Option D: It was withdrawn from the American market in 2000 due to its ability to cause serious adverse effects, including agranulocytosis.

" A

39941 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC(C1=CC2=C(C=C1)OC(=N2)C3=CC=C(C=C3)Cl)C(=O)O

Question about this molecule: What is the right withdrawn from market information about this molecule?

Option A: It was withdrawn from the market due to adverse side-effects including liver necrosis, photosensitivity, and carcinogenicity in animals.

Option B: It was withdrawn from the market in 1982 due to links with hepatitis.

Option C: It was withdrawn from the market following its association with cases of Stevens-Johnson syndrome.

Option D: It was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market.

" A

38409 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C1=CSC(=C1)C(=O)C2=C(C(=C(C=C2)OCC(=O)O)Cl)Cl

Question about this molecule: What is the right withdrawn from market information about this molecule?

Option A: It was withdrawn from the market following suspicions of carcenogenicity.

Option B: It was withdrawn from the market following its association with cases of Stevens-Johnson syndrome.

Option C: It was withdrawn from the market due to causing severe gastrointestinal bleeding.

Option D: It was withdrawn from the market in 1982 due to links with hepatitis.

" D