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10,737,486 | Prostate cancer is highly predictable: a prognostic equation based on all morphological variables in radical prostatectomy specimens. | The Journal of urology | J Urol | 163 | 4 | 10.1016/s0022-5347(05)67713-0 | eng | 2,000 | 4 | null | null | null | null | [PURPOSE] We determine whether biochemical prostate specific antigen (PSA) failure can be accurately predicted from preoperative serum PSA combined with 6 morphological variables from radical retropubic prostatectomy specimens in men with peripheral zone cancers. The unexpected limitation imposed by preoperative serum ... | null | 1.751 | 291 | Urology | Medicine | 2,000 |
10,737,480 | Maintenance bacillus Calmette-Guerin immunotherapy for recurrent TA, T1 and carcinoma in situ transitional cell carcinoma of the bladder: a randomized Southwest Oncology Group Study. | The Journal of urology | J Urol | 163 | 4 | null | eng | 2,000 | 4 | null | null | null | null | [PURPOSE] Bacillus Calmette-Guerin (BCG) immunotherapy has been widely accepted as the optimal treatment for carcinoma in situ and high grade superficial transitional cell carcinoma. However, controversy remains regarding the role of maintenance therapy, and its long-term effect on recurrence and progression. [MATERIAL... | null | 1.751 | 291 | Urology | Medicine | 2,000 |
10,736,499 | In vivo interstitial temperature mapping of the human prostate during cryosurgery with correlation to histopathologic outcomes. | Urology | Urology | 55 | 4 | 10.1016/s0090-4295(99)00590-7 | eng | 2,000 | 4 | null | null | null | null | [OBJECTIVES] To determine the critical temperatures below which human prostatic tissue can be cryoablated in situ and the comparative cryoablative efficacy of single versus double-freeze cryosurgery. [METHODS] Six patients with prostate cancer previously scheduled for prostatectomy underwent unilateral or bilateral cry... | null | 1.753 | 197 | Urology | Medicine | 2,000 |
10,736,290 | KB-R7943 block of Ca(2+) influx via Na(+)/Ca(2+) exchange does not alter twitches or glycoside inotropy but prevents Ca(2+) overload in rat ventricular myocytes. | Circulation | Circulation | 101 | 12 | 10.1161/01.cir.101.12.1441 | eng | 2,000 | 3 | 28 | null | null | null | [BACKGROUND] The Na(+)/Ca(2+) exchange (NCX) extrudes Ca(2+) from cardiac myocytes, but it can also mediate Ca(2+) influx, load the sarcoplasmic reticulum with Ca(2+), and trigger Ca(2+) release from the sarcoplasmic reticulum. In ischemia/reperfusion or digitalis toxicity, increased levels of intracellular [Na(+)] ([N... | null | 5.669 | 691 | Cardiology and Cardiovascular Medicine; Physiology | Medicine | 2,000 |
10,735,660 | Intensive chemotherapy and radical resections for primary nonseminomatous mediastinal germ cell tumors. | The Annals of thoracic surgery | Ann Thorac Surg | 69 | 2 | 10.1016/s0003-4975(99)01472-1 | eng | 2,000 | 2 | null | null | null | null | [BACKGROUND] Primary nonseminomatous germ cell tumors of the mediastinum (PNSGM), unlike malignancies of gonadal origin, have a poor prognosis. We report a single institutional experience over a 5-year period of PNSGM treated with intensive chemotherapy, followed by radical operation in those who responded to this neoa... | null | 1.356 | 230 | Cardiology and Cardiovascular Medicine; Pulmonary and Respiratory Medicine; Surgery | Medicine | 2,000 |
10,735,613 | Spleno-renal shunt blood flow is an accurate index of collateral circulation in different models of portal hypertension and after pharmacological changes in rats. | Journal of hepatology | J Hepatol | 32 | 3 | 10.1016/s0168-8278(00)80394-3 | eng | 2,000 | 3 | null | null | null | null | [BACKGROUND/AIMS] Recently, we developed a new method to measure collateral blood flow in rats: splenorenal shunt (SRS) blood flow (BF). The aims were to evaluate the reproducibility of SRSBF measurement in different models of portal hypertension, and to investigate the ability of SRSBF to disclose pharmacological chan... | null | 1.219 | 319 | Hepatology | Medicine | 2,000 |
10,735,426 | External beam irradiation as an adjunctive treatment in failing dialysis shunts. | Journal of vascular and interventional radiology : JVIR | J Vasc Interv Radiol | 11 | 3 | 10.1016/s1051-0443(07)61424-9 | eng | 2,000 | 3 | null | null | null | null | [PURPOSE] To evaluate the utility of low-dose irradiation as adjunctive treatment for failing dialysis shunts related to stenoses. [MATERIALS AND METHODS] Thirty-one patients with 41 lesions in their dialysis shunts were successfully enrolled for this study. After imaging of the shunt and calculation of venous stenoses... | null | 1.111 | 150 | Cardiology and Cardiovascular Medicine; Medicine; Radiology, Nuclear Medicine and Imaging | Medicine | 2,000 |
10,733,723 | Differences in teaching about the acute sore throat within one medical faculty. | Medical education | Med Educ | 34 | 4 | 10.1046/j.1365-2923.2000.00507.x | eng | 2,000 | 4 | null | null | null | null | [OBJECTIVES] To examine the consistency of teaching about the acute sore throat in four departments in one medical faculty, and to determine whether there is agreement between what is taught and the evidence-based literature. [DESIGN] Cross-sectional study. [SUBJECTS] 71 undergraduates and 15 postgraduate general pract... | null | 0.444 | 171 | Medicine; Education | Medicine; Social Sciences | 2,000 |
10,733,048 | Prevalent vertebral deformities predict mortality and hospitalization in older women with low bone mass. Fracture Intervention Trial Research Group. | Journal of the American Geriatrics Society | J Am Geriatr Soc | 48 | 3 | 10.1111/j.1532-5415.2000.tb02641.x | eng | 2,000 | 3 | null | null | null | null | [OBJECTIVES] To determine the relationship between prevalent vertebral deformities and the risk of mortality and hospitalization in older women with low bone mass. [DESIGN] A prospective cohort study. [SETTING] Eleven clinical centers in the United States. [PARTICIPANTS] A total of 6459 community-dwelling women with lo... | null | 1.823 | 273 | Geriatrics and Gerontology | Medicine | 2,000 |
10,731,526 | The rate at which human sperm are immobilized and killed by mild acidity. | Fertility and sterility | Fertil Steril | 73 | 4 | 10.1016/s0015-0282(99)00640-8 | eng | 2,000 | 4 | null | null | null | null | [OBJECTIVE] To determine the rate at which mild acidity immobilizes and kills human sperm and to evaluate an acidic microbicide, BufferGel, for sperm immobilization. [DESIGN] Controlled in vitro study. [SETTING] An academic research university and hospital andrology lab. [PATIENT(S)] Eight volunteer male sperm donors. ... | null | 1.515 | 252 | Obstetrics and Gynecology; Reproductive Medicine | Medicine | 2,000 |
10,731,455 | Training effects of accumulated daily stair-climbing exercise in previously sedentary young women. | Preventive medicine | Prev Med | 30 | 4 | 10.1006/pmed.2000.0634 | eng | 2,000 | 4 | null | null | null | null | [BACKGROUND] The health and fitness benefits associated with short, intermittent bouts of exercise accumulated throughout the day have been seldom investigated. Stair climbing provides an ideal model for this purpose. [METHODS] Twenty-two healthy female volunteers (18-22 years) were randomly assigned to control (N = 10... | null | 1.021 | 199 | Public Health, Environmental and Occupational Health; Epidemiology | Medicine | 2,000 |
10,730,799 | An analysis of printed breast cancer information for African American women. | Journal of cancer education : the official journal of the American Association for Cancer Education | J Cancer Educ | 15 | 1 | 10.1080/08858190009528648 | eng | 2,000 | null | null | null | null | null | [BACKGROUND] The 1995-1998 Delta Project was designed to increase breast cancer screening among disadvantaged African American women with limited literacy skills by educating their health care professionals about breast health. The research team intended to provide onsite training and appropriate educational materials;... | null | null | null | null | null | null |
10,728,417 | Gingerol, isoproterenol and ouabain normalize impaired post-rest behavior but not force-frequency relation in failing human myocardium. | Cardiovascular research | Cardiovasc Res | 45 | 4 | 10.1016/s0008-6363(99)00387-9 | eng | 2,000 | 3 | null | null | null | null | [OBJECTIVE] Rest- and stimulation frequency-dependent potentiation of contractile force is blunted in failing human myocardium. These alterations have been related to reduced sarcoplasmic reticulum (SR) Ca(2+)-reuptake and enhanced transsarcolemmal Ca(2+)-elimination by Na+/Ca(2+)-exchange. We investigated whether inot... | null | null | null | null | null | null |
10,728,388 | Inhibition of endogenous nitric oxide synthase potentiates ischemia-reperfusion-induced myocardial apoptosis via a caspase-3 dependent pathway. | Cardiovascular research | Cardiovasc Res | 45 | 3 | 10.1016/s0008-6363(99)00347-8 | eng | 2,000 | 2 | null | null | null | null | [OBJECTIVE] Apoptosis of cardiomyocytes may contribute to ischemia-reperfusion injury. The role of nitric oxide (NO) in apoptosis is controversial. Therefore, we investigated the effect of NO synthase inhibition on apoptosis of cardiomyocytes during ischemia and reperfusion and elucidated the underlying mechanisms. [ME... | null | null | null | null | null | null |
10,728,360 | Heterogeneous changes in action potential and intracellular Ca2+ in left ventricular myocyte sub-types from rabbits with heart failure. | Cardiovascular research | Cardiovasc Res | 45 | 2 | 10.1016/s0008-6363(99)00360-0 | eng | 2,000 | 1 | 14 | null | null | null | [OBJECTIVE] Myocardial cellular electrophysiology and intracellular Ca2+ regulation are altered in heart failure. The extent of these changes may vary within the layers of the ventricular wall. To examine this, cell size, action potential and intracellular Ca2+ transient characteristics (Fura-2) were measured in single... | null | null | null | null | null | null |
10,727,489 | Clinical, electrophysiological, and molecular genetic studies in a new family with paramyotonia congenita. | Journal of neurology, neurosurgery, and psychiatry | J Neurol Neurosurg Psychiatry | 68 | 4 | 10.1136/jnnp.68.4.504 | eng | 2,000 | 4 | null | null | null | null | [OBJECTIVES] To characterise the clinical and electrophysiological features and to determine the molecular genetic basis of pure paramyotonia congenita in a previously unreported large Irish kindred. [METHODS] Clinical and neurophysiological examination was performed on three of the five affected family members. Five u... | null | 1.317 | 244 | Neurology; Psychiatry and Mental Health; Surgery | Medicine | 2,000 |
10,727,358 | Internal carotid artery stenosis: rate of progression. | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery | Eur J Vasc Endovasc Surg | 19 | 2 | 10.1053/ejvs.1999.0951 | eng | 2,000 | 2 | null | null | null | null | [OBJECTIVES] to assess the incidence and the rate of progression of internal carotid artery (ICA) stenosis and to determine the related risk factors. [DESIGN] open prospective study. [MATERIALS AND METHODS] between 1988-1997, 442 carotid arteries with various degrees of stenosis were followed using colour duplex ultras... | null | 1.128 | 144 | Cardiology and Cardiovascular Medicine; Surgery | Medicine | 2,000 |
10,726,800 | Choroidal Langerhans' cell histiocytosis. | Acta ophthalmologica Scandinavica | Acta Ophthalmol Scand | 78 | 1 | 10.1034/j.1600-0420.2000.078001097.x | eng | 2,000 | 2 | null | null | null | null | [PURPOSE] To report a patient with choroidal Langerhans' cell histiocytosis. [METHODS] A solitary tumor was found in the left eye of a 49-year-old male who had no definite history of systemic disorders, but had observed visual disturbances for a period of 1 month. Ultrasonography, fluorescein angiography, and indocyani... | null | null | null | null | null | null |
10,726,734 | Evaluation of IgE antibodies to recombinant pollen allergens (Phl p 1, Phl p 2, and Phl p 5) in a random sample of patients with specific IgE to Phleum pratense. | Allergy | Allergy | 55 | 2 | 10.1034/j.1398-9995.2000.00320.x | eng | 2,000 | 2 | null | null | null | null | [BACKGROUND] We measured specific IgE levels against the recombinant allergens (RAs) rPhl p 1, rPhl p 2, and rPhl p 5 in patients allergic to grass pollen, and examined the existence of different patterns of IgE production to RAs. The seasonal variations of IgE levels to rPhl p 1, rPhl p 2, and rPhl p 5 were considered... | null | 0.882 | 213 | Immunology; Immunology and Allergy | Immunology and Microbiology; Medicine | 2,000 |
10,726,679 | RNA differential display of scarless wound healing in fetal rabbit indicates downregulation of a CCT chaperonin subunit and upregulation of a glycophorin-like gene transcript. | Journal of pediatric surgery | J Pediatr Surg | 35 | 3 | 10.1016/s0022-3468(00)90204-5 | eng | 2,000 | 3 | null | null | null | null | [BACKGROUND/PURPOSE] Scars form as wounds heal in adult organisms. In addition to disrupting cosmetic appearance, scar tissue can cause significant morbidity, and even death if it blocks vital organ function. Previous work has established that fetal wounds, especially in early to midgestation, can heal without scarring... | null | 0.994 | 147 | Medicine; Pediatrics, Perinatology and Child Health; Surgery | Medicine | 2,000 |
10,725,574 | Adverse effects of epidural analgesia in labor. | European journal of obstetrics, gynecology, and reproductive biology | Eur J Obstet Gynecol Reprod Biol | 89 | 2 | 10.1016/s0301-2115(99)00191-8 | eng | 2,000 | 4 | null | null | null | null | [OBJECTIVE] To examine the influence of epidural analgesia on labor and delivery in nulliparous and multiparous women. [DESIGN] Data were collected on 847 consecutive parturients with singleton pregnancy and vertex presentation (384 nulliparous and 463 multiparous). The obstetrical and labor characteristics including m... | null | null | null | null | null | null |
10,724,496 | Synthetic retinoids improve survival in rodent model of endotoxic shock. | The European journal of surgery = Acta chirurgica | Eur J Surg | 166 | 2 | 10.1080/110241500750009537 | eng | 2,000 | 2 | null | null | null | null | [OBJECTIVE] To investigate the effect of synthetic retinoids on septic shock induced by lipopolysaccharide (LPS) in rats. [DESIGN] Randomised study. [SETTINGS] University hospital laboratory, Sweden. [ANIMALS AND INTERVENTIONS] 31 male Sprague Dawley rats randomised into four groups: controls, given vehicle alone (n = ... | null | null | null | null | null | null |
10,724,071 | Anatomic motor point localization for partial quadriceps block in spasticity. | Archives of physical medicine and rehabilitation | Arch Phys Med Rehabil | 81 | 3 | 10.1016/s0003-9993(00)90072-8 | eng | 2,000 | 3 | null | null | null | null | [OBJECTIVE] To identify the location of the vastus intermedius nerve and its motor point (point M) and to precisely identify its coordinates in relation to anatomic surface landmarks. [DESIGN] Descriptive study. [SETTING] Anatomy institute of a university school of medicine. [PARTICIPANTS] Twenty-nine adult cadaver lim... | null | 0.838 | 225 | Physical Therapy, Sports Therapy and Rehabilitation; Rehabilitation; Sports Science | Health Professions; Medicine | 2,000 |
10,722,183 | Thought disorder index of Finnish adoptees and communication deviance of their adoptive parents. | Psychological medicine | Psychol Med | 30 | 1 | 10.1017/s0033291799001415 | eng | 2,000 | 1 | null | null | null | null | [BACKGROUND] Diverse forms of thought disorder, as measured by the Thought Disorder Index (TDI), are found in many conditions other than schizophrenia. Certain thought disorder categories are primarily manifest during psychotic schizophrenic episodes. The present study examined whether forms of thought disorder qualify... | null | 3.018 | 251 | Applied Psychology; Psychiatry and Mental Health | Medicine; Psychology | 2,000 |
10,722,173 | Risk factors and life processes associated with the onset of suicidal behaviour during adolescence and early adulthood. | Psychological medicine | Psychol Med | 30 | 1 | 10.1017/s003329179900135x | eng | 2,000 | 1 | null | null | null | null | [BACKGROUND] This study examined associations between childhood circumstances, adolescent mental health and life events, and the development of suicidal behaviour in young people aged between 15 and 21 years. [METHOD] Data were gathered over the course of a 21-year longitudinal study of a birth cohort of 1265 children ... | null | 3.018 | 251 | Applied Psychology; Psychiatry and Mental Health | Medicine; Psychology | 2,000 |
10,722,027 | Papillary thyroid carcinoma: prognostic index for survival including the histological variety. | Archives of surgery (Chicago, Ill. : 1960) | Arch Surg | 135 | 3 | 10.1001/archsurg.135.3.272 | eng | 2,000 | 3 | null | null | null | null | [BACKGROUND] Numerous prognostic factors have been studied for survival in patients with papillary thyroid carcinoma (PTC), although there are few multivariate studies that include the histological variety of PTC. [HYPOTHESIS] There are prognostic factors that influence survival in a series of patients with PTC, includ... | null | null | null | null | null | null |
10,721,396 | Follow-up of patients with arrhythmogenic right ventricular cardiomyopathy dysplasia. | South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde | S Afr Med J | 90 | 1 | null | eng | 2,000 | 1 | null | null | null | null | [OBJECTIVE] The enlargement of data on the natural course and management of patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). [DESIGN] Retrospective and partly prospective observational study. [SETTING] Cardiac Unit, Wentworth Hospital, Durban--the only unit in KwaZulu-Natal providing an... | null | null | null | null | null | null |
10,720,864 | Deep dorsal vein arterialization in pure cavernoocclusive dysfunction. | European urology | Eur Urol | 37 | 3 | 10.1159/000052368 | eng | 2,000 | 3 | null | null | null | null | [PURPOSE] We report our 4-year experience with deep dorsal vein arterialization at 3 years' follow-up in young patients with pure cavernoocclusive dysfunction as an alternative to penile prosthesis implantation. [MATERIALS AND METHODS] We performed a modified Furlow-Fisher operation (circumflex collaterals are preserve... | null | 1.126 | 274 | Urology | Medicine | 2,000 |
10,720,278 | A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection. AIDS Clinical Trials Group Team 291. | Neurology | Neurology | 54 | 5 | 10.1212/wnl.54.5.1080 | eng | 2,000 | 3 | 14 | null | null | null | [OBJECTIVE] To evaluate the safety and efficacy of recombinant human nerve growth factor (rhNGF) in HIV-associated sensory neuropathy (SN) within a multicenter, placebo-controlled, randomized trial (ACTG 291). [BACKGROUND] SN affects 30% of individuals with AIDS, is worsened by neurotoxic antiretrovirals, and its treat... | null | 2.317 | 422 | Neurology | Medicine | 2,000 |
10,720,270 | Longitudinal ocular motor study in corticobasal degeneration and progressive supranuclear palsy. | Neurology | Neurology | 54 | 5 | 10.1212/wnl.54.5.1029 | eng | 2,000 | 3 | 14 | null | null | null | [OBJECTIVE] To evaluate the usefulness of ocular motor information in the early diagnosis of corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). [METHODS] Seven PSP patients, six CBD patients, and three atypical CBD patients were followed longitudinally with repeated electrooculographic (EOG) reco... | null | 2.317 | 422 | Neurology | Medicine | 2,000 |
10,719,945 | Comparison of blood-conservation strategies in cardiac surgery patients at high risk for bleeding. | Anesthesiology | Anesthesiology | 92 | 3 | 10.1097/00000542-200003000-00010 | eng | 2,000 | 3 | null | null | null | null | [BACKGROUND] Aprotinin and tranexamic acid are routinely used to reduce bleeding in cardiac surgery. There is a large difference in agent price and perhaps in efficacy. [METHODS] In a prospective, randomized, partially blinded study, 168 cardiac surgery patients at high risk for bleeding received either a full-dose apr... | null | null | null | null | null | null |
10,718,855 | N-terminal sequences of high molecular weight allergens from celery tuber. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology | Clin Exp Allergy | 30 | 4 | 10.1046/j.1365-2222.2000.00773.x | eng | 2,000 | 4 | null | null | null | null | [BACKGROUND] Celery tuber is an important source of food allergens. Low molecular weight celery allergens were identified as homologues of Bet v 1 and profilin. Little is known about the relevant allergens with molecular weights between 45 and 60 kDa, which cross-react with other plant food and pollen allergens. [OBJEC... | null | 1.551 | 176 | Immunology; Immunology and Allergy | Immunology and Microbiology; Medicine | 2,000 |
10,718,784 | Gastric decontamination performed 5 min after the ingestion of temazepam, verapamil and moclobemide: charcoal is superior to lavage. | British journal of clinical pharmacology | Br J Clin Pharmacol | 49 | 3 | 10.1046/j.1365-2125.2000.00138.x | eng | 2,000 | 3 | null | null | null | null | [AIMS] The aim was to study the efficacy of gastric lavage and activated charcoal in preventing the absorption of temazepam, verapamil and moclobemide when gastric decontamination was performed immediately after ingestion of the drugs. [METHODS] Nine healthy volunteers took part in a randomized cross-over study with th... | null | 0.882 | 176 | Pharmacology; Pharmacology | Medicine; Pharmacology, Toxicology and Pharmaceutics | 2,000 |
10,718,695 | Age-specific patterns of prostate-specific antigen testing among primary care physician visits. | The Journal of family practice | J Fam Pract | 49 | 2 | null | eng | 2,000 | 2 | null | null | null | null | [BACKGROUND] Early detection of prostate cancer is thought to be effective, and indirect evidence suggests that men aged 50 to 69 years will benefit most while those aged 70 and older will benefit least from it. The goal of our study was to describe usual care patterns for prostate-specific antigen (PSA) testing by pri... | null | null | null | null | null | null |
10,716,686 | Increased availability of central benzodiazepine receptors in patients with chronic hepatic encephalopathy and alcohol related cirrhosis. | Gut | Gut | 46 | 4 | 10.1136/gut.46.4.546 | eng | 2,000 | 4 | null | null | null | null | [BACKGROUND/AIMS] To measure cerebral benzodiazepine receptor binding using (11)C-flumazenil positron emission tomography in patients with stable chronic hepatic encephalopathy, who were also characterised by proton magnetic resonance spectroscopy. [METHODS] Six abstinent patients of mean age 61 years with alcohol rela... | null | 1.953 | 364 | Gastroenterology | Medicine | 2,000 |
10,716,135 | Efficacy and safety of valsartan compared with enalapril at different altitudes. | International journal of cardiology | Int J Cardiol | 72 | 3 | 10.1016/s0167-5273(99)00194-1 | eng | 2,000 | 2 | 15 | null | null | null | [OBJECTIVE] To compare the safety, tolerability, and antihypertensive efficacy of valsartan with enalapril at different altitudes. [METHOD] A total of 142 adult Colombian outpatients with mild to moderate essential hypertension were recruited in 3 cities at different altitudes (Bogotá at 2600 m, Medellin at 1538 m and ... | null | 0.547 | 155 | Cardiology and Cardiovascular Medicine | Medicine | 2,000 |
10,715,748 | Accuracy of the estimated prevalence of obesity from self reported height and weight in an adult Scottish population. | Journal of epidemiology and community health | J Epidemiol Community Health | 54 | 2 | 10.1136/jech.54.2.143 | eng | 2,000 | 2 | null | null | null | null | [STUDY OBJECTIVE] To determine whether self reported heights and weights from Scottish adults can provide an accurate assessment of obesity prevalence in the population. [DESIGN] Standardised clinic measurements of weight and height were compared against self reported values on a postal questionnaire in the fourth Scot... | null | 1.134 | 199 | Public Health, Environmental and Occupational Health; Epidemiology | Medicine | 2,000 |
10,715,300 | CD56 expression is an indicator of poor clinical outcome in patients with acute promyelocytic leukemia treated with simultaneous all-trans-retinoic acid and chemotherapy. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology | J Clin Oncol | 18 | 6 | 10.1200/JCO.2000.18.6.1295 | eng | 2,000 | 3 | null | null | null | null | [PURPOSE] Preliminary reports suggest that leukemic cell expression of CD56, a neural cell adhesion molecule, is associated with adverse clinical outcome in either acute myeloid leukemia with t(8;21) or acute promyelocytic leukemia (APL). We investigated the prognostic relevance of CD56 in a series of patients with APL... | null | 3.972 | 646 | Cancer Research; Medicine; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,000 |
10,715,286 | Results of treatment after relapse from high-dose chemotherapy in germ cell tumors. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology | J Clin Oncol | 18 | 6 | 10.1200/JCO.2000.18.6.1181 | eng | 2,000 | 3 | null | null | null | null | [PURPOSE] To identify therapy-related or patient-related characteristics that predict response and long-term survival after failure of high-dose chemotherapy (HDCT) for germ cell tumors (GCT). [PATIENTS AND METHODS] Between 1986 and 1997, 101 GCT patients relapsed after high-dose carboplatin and etoposide (VP-16) at In... | null | 3.972 | 646 | Cancer Research; Medicine; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,000 |
10,715,268 | Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium. | Circulation | Circulation | 101 | 10 | 10.1161/01.cir.101.10.1192 | eng | 2,000 | 3 | 14 | null | null | null | [BACKGROUND] Certain alterations by mutations or drugs of the potassium currents I(Ks) and I(Kr) and the sodium current I(Na) give rise to several types of the long-QT syndrome. I(Ks) is heterogeneously distributed across the ventricular wall. [METHODS AND RESULTS] We investigated the effects of reducing I(Ks) or I(Kr)... | null | 5.669 | 691 | Cardiology and Cardiovascular Medicine; Physiology | Medicine | 2,000 |
10,714,616 | Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres. | Pharmaceutical research | Pharm Res | 17 | 1 | 10.1023/a:1007582911958 | eng | 2,000 | 1 | null | null | null | null | [PURPOSE] In the past decade, biodegradable polymers have become the materials of choice for a variety of biomaterials applications. In particular, poly(lactic-co-glycolic acid) (PLGA) microspheres have been extensively studied for controlled-release drug delivery. However, degradation of the polymer generates acidic m... | null | 1.067 | 235 | Biotechnology; Organic Chemistry; Pharmaceutical Science; Pharmacology; Pharmacology; Molecular Medicine | Biochemistry, Genetics and Molecular Biology; Chemistry; Medicine; Pharmacology, Toxicology and Pharmaceutics | 2,000 |
10,714,611 | Evaluation of blood-brain barrier passage of a muscarine M1 agonist and a series of analogous tetrahydropyridines measured by in vivo microdialysis. | Pharmaceutical research | Pharm Res | 17 | 1 | 10.1023/a:1007522626070 | eng | 2,000 | 1 | null | null | null | null | [PURPOSE] To investigate the blood-brain barrier (BBB) passage of the M1 muscarine agonist Lu 25-109 (5-(2-Ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-methylpyridine) and potential metabolites using in vivo microdialysis. [METHODS] Anesthetized rats were administered an intravenous infusion of one of seven analogs with ... | null | 1.067 | 235 | Biotechnology; Organic Chemistry; Pharmaceutical Science; Pharmacology; Pharmacology; Molecular Medicine | Biochemistry, Genetics and Molecular Biology; Chemistry; Medicine; Pharmacology, Toxicology and Pharmaceutics | 2,000 |
10,714,257 | The effect of octreotide on postoperative adhesion formation. | Canadian journal of surgery. Journal canadien de chirurgie | Can J Surg | 43 | 1 | null | eng | 2,000 | 2 | null | null | null | null | [OBJECTIVE] To investigate the effect of octreotide, a long-acting analogue of somatostatin, on postoperative adhesion formation, because somatostatin inhibits secretion of some growth factors that have modulatory effects on collagen synthesis. [DESIGN] An experimental study. [SETTING] Surgical Research and Biochemistr... | null | null | null | null | null | null |
10,714,019 | Clinical experience of Argatroban for anticoagulation in cardiovascular surgery. | The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi | Jpn J Thorac Cardiovasc Surg | 48 | 1 | 10.1007/BF03218083 | eng | 2,000 | 1 | null | null | null | null | [PURPOSE] We have reviewed our experience with Argatroban-a direct thrombin inhibitor for anticoagulation--in a variety of cardiovascular operations, and in extracorporeal circulation, as a substitute for heparin. [SUBJECTS AND METHODS] 60 patients receiving anticoagulation with Argatroban were classified into the foll... | null | null | null | null | null | null |
10,714,015 | Combined thoracic aortic or upper digestive tract resection for lung cancer and malignant mediastinal tumor. | The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi | Jpn J Thorac Cardiovasc Surg | 48 | 1 | 10.1007/BF03218079 | eng | 2,000 | 1 | null | null | null | null | [OBJECTIVE] We studied possible indications and combined resection in patients with lung cancer and mediastinal tumors requiring combined thoracic aortic or upper digestive tract resection. [METHODS] Ten patients with lung cancer and malignant mediastinal tumors (9 men and 1 woman aged 39 to 72 years; mean: 60.5) under... | null | null | null | null | null | null |
10,713,646 | Dermatomyositis and polymyositis associated with the antiphospholipid syndrome-a novel overlap syndrome. | Lupus | Lupus | 9 | 1 | 10.1177/096120330000900108 | eng | 2,000 | null | null | null | null | null | [OBJECTIVE] As APS (antiphospholipid syndrome) can be either primary or secondary to a wide range of other conditions (such as autoimmune diseases, malignancies, infectious diseases, and drug-induced conditions) the aim of this study was to describe a novel overlap syndrome of APS. [METHODS] All patients diagnosed with... | null | 0.757 | 122 | Rheumatology | Medicine | 2,000 |
10,713,231 | Phakic posterior chamber lenses for high myopia: functional and anatomical outcomes. | Journal of cataract and refractive surgery | J Cataract Refract Surg | 26 | 3 | 10.1016/s0886-3350(99)00417-4 | eng | 2,000 | 3 | null | null | null | null | [PURPOSE] To evaluate the functional and the anatomical outcomes after implantation of phakic posterior chamber intraocular lenses (IOLs) in highly myopic eyes. [SETTING] Service d'Ophtalmologie, Hôpital Purpan, Toulouse, France. [METHODS] Fifty-eight eyes of 46 patients that had implantation of phakic posterior chambe... | null | 1.883 | 169 | Ophthalmology; Sensory Systems; Surgery | Medicine; Neuroscience | 2,000 |
10,712,992 | Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. | Chest | Chest | 117 | 3 | 10.1378/chest.117.3.684 | eng | 2,000 | 3 | null | null | null | null | [BACKGROUND] A central feature in the pathogenesis of COPD is the inflammation coexisting with an abnormal protease/antiprotease balance. However, the possible role of different serine and metalloproteinases remains controversial. [PATIENTS AND MEASUREMENTS] We examined the expression of gelatinases A and B (matrix met... | null | 1.002 | 337 | Cardiology and Cardiovascular Medicine; Critical Care and Intensive Care Medicine; Pulmonary and Respiratory Medicine | Medicine | 2,000 |
10,712,928 | Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains. | Chemistry & biology | Chem Biol | 7 | 3 | 10.1016/s1074-5521(00)00091-0 | eng | 2,000 | 3 | null | null | null | null | [BACKGROUND] Nonribosomal peptide synthetases (NRPSs) are large modular proteins that selectively bind, activate and condense amino acids in an ordered manner. Substrate recognition and activation occurs by reaction with ATP within the adenylation (A) domain of each module. Recently, the crystal structure of the A doma... | null | null | null | null | null | null |
10,711,885 | Visual outcomes following the use of intravitreal steroids in the treatment of postoperative endophthalmitis. | Ophthalmology | Ophthalmology | 107 | 3 | 10.1016/s0161-6420(99)00139-6 | eng | 2,000 | 3 | null | null | null | null | [OBJECTIVE] To compare visual outcomes between cases of acute postoperative endophthalmitis that did or did not receive intravitreal steroids. [DESIGN] Retrospective nonrandomized comparative trial. [PARTICIPANTS] Fifty-seven patients with postoperative endophthalmitis. [INTERVENTION] Thirty-one patients with postopera... | null | 2.651 | 297 | Ophthalmology | Medicine | 2,000 |
10,711,681 | The use of atomic force microscopy for the observation of corneal epithelium surface. | Investigative ophthalmology & visual science | Invest Ophthalmol Vis Sci | 41 | 3 | null | eng | 2,000 | 3 | null | null | null | null | [PURPOSE] To evaluate the feasibility of imaging normal corneal epithelium by means of atomic force microscopy (AFM). [METHODS] Twelve normal corneas from six albino rabbits were examined using a commercial atomic force microscope. Six corneas were examined in balanced salt solution after fixation in glutaraldehyde 2.5... | null | null | null | null | null | null |
10,711,676 | Fas mediates apoptosis and oxidant-induced cell death in cultured hRPE cells. | Investigative ophthalmology & visual science | Invest Ophthalmol Vis Sci | 41 | 3 | null | eng | 2,000 | 3 | null | null | null | null | [PURPOSE] To investigate whether Fas ligand (FasL) and the Fas receptor system mediates apoptosis in cultured human retinal pigment epithelial (hRPE) cells and contributes to oxidant-induced death of hRPE cells. [METHODS] Expression of FasL and Fas in cultured hRPE cells was examined by Western blot analysis and flow c... | null | null | null | null | null | null |
10,710,076 | Work loss costs due to peptic ulcer disease and gastroesophageal reflux disease in a health maintenance organization. | The American journal of gastroenterology | Am J Gastroenterol | 95 | 3 | 10.1111/j.1572-0241.2000.01861.x | eng | 2,000 | 3 | null | null | null | null | [OBJECTIVE] The aim of this study was to estimate the value of work time and productivity loss because of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). [METHODS] A total of 300 adult members of Northern California Kaiser Permanente Medical Care Program with outpatient diagnoses of PUD or GERD w... | null | 1.058 | 296 | Gastroenterology; Hepatology | Medicine | 2,000 |
10,710,065 | A meta-analysis of antimycobacterial therapy for Crohn's disease. | The American journal of gastroenterology | Am J Gastroenterol | 95 | 3 | 10.1111/j.1572-0241.2000.01842.x | eng | 2,000 | 3 | null | null | null | null | [OBJECTIVE] Various therapies have been studied for the treatment of Crohn's disease, including antimycobacterial therapy. Meta-analysis was used to evaluate the effect of antimycobacterial therapy in patients with Crohn's disease. [METHODS] Randomized, controlled trials comparing antimycobacterial therapy with placebo... | null | 1.058 | 296 | Gastroenterology; Hepatology | Medicine | 2,000 |
10,708,836 | Parental child-rearing behavior as measured by the Parental Bonding Instrument in a Japanese population: factor structure and relationship to a lifetime history of depression. | Journal of affective disorders | J Affect Disord | 57 | 1-3 | 10.1016/s0165-0327(99)00071-3 | eng | 2,000 | null | null | null | null | null | [BACKGROUND] Recent factor analyses showed that the variance of the Parental Bonding Instrument (PBI) was more satisfactorily explained by the use of three factors (one factor corresponding to the original care factor and two factors derived from the original protection factor), casting doubt as to the accuracy of prev... | null | 1.451 | 245 | Clinical Psychology; Psychiatry and Mental Health | Medicine; Psychology | 2,000 |
10,708,234 | Isolation of short-wavelength sensitive mechanisms in normal and glaucomatous visual field regions. | Journal of glaucoma | J Glaucoma | 9 | 1 | 10.1097/00061198-200002000-00012 | eng | 2,000 | 2 | null | null | null | null | [PURPOSE] To determine whether "isolation" of short wavelength sensitive mechanisms (i.e., exclusive detection of a threshold stimulus by a short wavelength sensitive mechanism) is maintained in areas of glaucomatous visual field damage as measured with short-wavelength automated perimetry (SWAP). [METHODS] Data from c... | null | 1.308 | 105 | Ophthalmology | Medicine | 2,000 |
10,708,232 | Changes in anterior chamber depth and angle width after filtration surgery: a quantitative study using ultrasound biomicroscopy. | Journal of glaucoma | J Glaucoma | 9 | 1 | 10.1097/00061198-200002000-00010 | eng | 2,000 | 2 | null | null | null | null | [PURPOSE] To evaluate the anterior chamber configuration by means of ultrasound biomicroscopy in patients with glaucoma and control subjects, and to determine quantitative changes in this configuration after glaucoma filtration surgery (trabeculectomy) and combined cataract and filtration surgery. [METHODS] The study i... | null | 1.308 | 105 | Ophthalmology | Medicine | 2,000 |
10,707,787 | The CUP trial: a randomized study analyzing the efficacy of high dose therapy and purging in low-grade non-Hodgkin's lymphoma (NHL). | Annals of oncology : official journal of the European Society for Medical Oncology | Ann Oncol | 11 Suppl 1 | null | null | eng | 2,000 | null | null | null | null | null | [BACKGROUND] The CUP trial was initiated to analyze the value of high-dose therapy and stem-cell transplantation and purging in patients with relapsed chemosensitive follicular NHL. [PATIENTS AND METHODS] After three cycles of chemotherapy responsive patients were randomized to either three more cycles of the same chem... | null | 1.005 | 311 | Hematology; Medicine; Oncology | Medicine | 2,000 |
10,707,771 | Lymphoma classification--from controversy to consensus: the R.E.A.L. and WHO Classification of lymphoid neoplasms. | Annals of oncology : official journal of the European Society for Medical Oncology | Ann Oncol | 11 Suppl 1 | null | null | eng | 2,000 | null | null | null | null | null | [BACKGROUND] Controversy in lymphoma classification dates back to the first attempts to formulate such classifications. Over the years, much of this controversy arose from the assumption that there had to be a single guiding principle--a 'gold standard'--for classification, and from the existence of multiple different ... | null | 1.005 | 311 | Hematology; Medicine; Oncology | Medicine | 2,000 |
10,707,753 | Effects of infusion of glucose-insulin-potassium on myocardial function after a recent myocardial infarction. | Acta cardiologica | Acta Cardiol | 55 | 1 | 10.2143/AC.55.1.2005712 | eng | 2,000 | 2 | null | null | null | null | [UNLABELLED] We studied the effects of glucose, insulin, and KCl infusion (GIK), on regional myocardial perfusion and function by 99m-Tc-tetrofosmin-gated SPECT. [METHODS] We studied 21 male patients with their first uncomplicated acute myocardial infarction (AMI). All patients underwent a rest and submaximal stress be... | null | 0.249 | 45 | Medicine; Cardiology and Cardiovascular Medicine | Medicine | 2,000 |
10,706,168 | Perceived consequences of teenage childbearing among adolescent girls in an urban sample. | The Journal of adolescent health : official publication of the Society for Adolescent Medicine | J Adolesc Health | 26 | 3 | 10.1016/s1054-139x(99)00067-1 | eng | 2,000 | 3 | null | null | null | null | [PURPOSE] The purpose of this study was to examine the perceived positive consequences of teenage childbearing among female adolescents, and to determine whether perceived consequences of teenage childbearing are associated with other attitudes and sexual risk behaviors. [METHODS] The sample consisted of 584 female stu... | null | 0.884 | 204 | Pediatrics, Perinatology and Child Health; Psychiatry and Mental Health; Public Health, Environmental and Occupational Health | Medicine | 2,000 |
10,706,076 | Thrombopoietin can influence mature megakaryocytes to undergo further nuclear and cytoplasmic maturation. | Experimental hematology | Exp Hematol | 28 | 2 | 10.1016/s0301-472x(99)00138-1 | eng | 2,000 | 2 | null | null | null | null | [OBJECTIVE] We studied the effects of TPO on the nuclear and cytoplasmic maturation of mature megakaryocytes. [MATERIALS AND METHODS] We prepared mature megakaryocytes by velocity sedimentation method and investigated the maturational effect of TPO on such mature megakaryocytes from the aspects of DNA ploidy and cytopl... | null | 0.45 | 131 | Hematology; Cancer Research; Cell Biology; Genetics; Molecular Biology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,000 |
10,706,060 | Graft-versus-host-disease-associated thymic damage results in the appearance of T cell clones with anti-host reactivity. | Transplantation | Transplantation | 69 | 3 | 10.1097/00007890-200002150-00026 | eng | 2,000 | 2 | 15 | null | null | null | [BACKGROUND] We studied whether T-cell clones, which appear in the periphery as a result of the failure of thymic negative selection during graft-versus-host disease (GVHD), have any in vivo anti-host reactivity and can cause GVHD in an adoptive transfer model. [METHODS] We performed our studies in a murine model (B10.... | null | 2.115 | 224 | Transplantation | Medicine | 2,000 |
10,705,849 | New NHLBI clinical guidelines for obesity and overweight: will they promote health? | American journal of public health | Am J Public Health | 90 | 3 | 10.2105/ajph.90.3.340 | eng | 2,000 | 3 | null | null | null | null | [OBJECTIVES] The purpose of this study was to assess the justification, on the basis of mortality, of the new National Heart, Lung, and Blood Institute (NHLBI) guidelines on obesity and overweight and to discuss the health implications of declaring all adults with a body mass index of 25 through 29 "overweight." [METHO... | null | 2.126 | 321 | Public Health, Environmental and Occupational Health | Medicine | 2,000 |
10,705,267 | Therapeutic equivalence and acceptability of two multidose powder inhalers in the treatment of asthma. | Respiration; international review of thoracic diseases | Respiration | 67 | 1 | 10.1159/000029467 | eng | 2,000 | null | null | null | null | null | [BACKGROUND] Problems in using conventional inhalation aerosols, in addition to environmental reasons, have driven development of the dry powder inhalers. [OBJECTIVE] To compare therapeutic equivalence and acceptability of two dry powder inhalers, Easyhaler (EH) and Diskhaler (DH), in the delivery of beclomethasone dip... | null | null | null | null | null | null |
10,705,260 | Co-expression of vascular endothelial growth factor and its receptor flt-1 in malignant pleural mesothelioma. | Respiration; international review of thoracic diseases | Respiration | 67 | 1 | 10.1159/000029460 | eng | 2,000 | null | null | null | null | null | [BACKGROUND] Vascular endothelial growth factor (VEGF) is a potent angiogenic protein with a selective mitogenic effect on endothelial cells known to be involved in many normal and pathological processes. Coexpression of VEGF and its receptor flt-1 has been reported in different types of malignant tumors. [OBJECTIVE] I... | null | null | null | null | null | null |
10,704,952 | The effect of family status and schizotypy on electrophysiologic measures of attention and semantic processing. | Biological psychiatry | Biol Psychiatry | 47 | 5 | 10.1016/s0006-3223(99)00184-5 | eng | 2,000 | 3 | 1 | null | null | null | [BACKGROUND] Disturbances in both attention and language are central to the phenomenology of the schizophrenia spectrum disorders. The purpose of this study was to investigate the relative contributions of two factors, family status and schizotypy, on electrophysiologic measures of attention and semantic processing in ... | null | 2.239 | 367 | Biological Psychiatry | Neuroscience | 2,000 |
10,704,557 | Diffuse interface keratitis after laser in situ keratomileusis (LASIK): a nonspecific syndrome. | American journal of ophthalmology | Am J Ophthalmol | 129 | 3 | 10.1016/s0002-9394(99)00386-4 | eng | 2,000 | 3 | null | null | null | null | [PURPOSE] To characterize the presentation of diffuse interface keratitis after laser in-situ keratomileusis (LASIK). [METHODS] Case report. [RESULTS] Diffuse interface keratitis occurred in the left eye of a postoperative LASIK patient after central epithelial debridement without exposure of the flap margin or elevati... | null | 1.709 | 221 | Ophthalmology | Medicine | 2,000 |
10,704,555 | Epstein-Barr virus dacryoadenitis. | American journal of ophthalmology | Am J Ophthalmol | 129 | 3 | 10.1016/s0002-9394(99)00351-7 | eng | 2,000 | 3 | null | null | null | null | [PURPOSE] To describe the clinical features of lacrimal gland inflammation associated with Epstein-Barr virus infection. [METHODS] The clinical records, laboratory data, and radiographs of patients who had inflammation of one or both lacrimal glands that had begun less than 4 weeks previously were reviewed. [RESULTS] S... | null | 1.709 | 221 | Ophthalmology | Medicine | 2,000 |
10,702,770 | Impact of the Peroxisome Proliferator Activated Receptor gamma2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus. | International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity | Int J Obes Relat Metab Disord | 24 | 2 | 10.1038/sj.ijo.0801112 | eng | 2,000 | 2 | null | null | null | null | [OBJECTIVE] The Pro12Ala polymorphism of the Peroxisome Proliferator Activated Receptor gamma2 (PPARgamma2) gene has been inconsistently associated with body mass index variations and non-insulin-dependent diabetes mellitus (NIDDM). We investigated the impact of this polymorphism on obesity markers, lipid and glucose v... | null | null | null | null | null | null |
10,701,806 | Stimulus motion increases measured visual field extent in children 3.5 to 30 months of age. | Optometry and vision science : official publication of the American Academy of Optometry | Optom Vis Sci | 77 | 2 | 10.1097/00006324-200002000-00012 | eng | 2,000 | 2 | null | null | null | null | [PURPOSE] To examine the influence of stimulus motion on measured visual field extent of 3.5- to 30-month-old children and adults. [METHODS] Each subject was tested with LED-hybrid and LED-kinetic perimetry procedures, using a black double-arc perimeter. Targets in both procedures were identical in size, color, luminan... | null | 0.691 | 121 | Ophthalmology; Optometry | Health Professions; Medicine | 2,000 |
10,700,530 | Quality of life in long-term home enteral nutrition patients. | Clinical nutrition (Edinburgh, Scotland) | Clin Nutr | 19 | 1 | 10.1054/clnu.1999.0068 | eng | 2,000 | 2 | null | null | null | null | [BACKGROUND AND AIMS] Few data are available on the quality of life of home enteral nutrition (HEN) patients. This study was designed to assess both the quality of life of long-term HEN patients and the evolution of quality of life after initiation of HEN. [METHODS] Quality of life-related parameters were analysed in 3... | null | 0.334 | 183 | Critical Care and Intensive Care Medicine; Nutrition and Dietetics | Medicine; Nursing | 2,000 |
10,824,658 | Relationships between hostility and physiological coronary heart disease risk factors in young adults: the moderating influence of depressive tendencies. | Psychological medicine | Psychol Med | 30 | 2 | 10.1017/s0033291700001720 | eng | 2,000 | 3 | null | null | null | null | [BACKGROUND] We examined whether the relationships between hostility and physiological coronary heart disease (CHD) risk factors differ as a function of depressive tendencies (DT). [METHODS] The participants were 672 randomly selected healthy young adults who self-reported their hostility (anger, cynicism, and paranoia... | null | 3.018 | 251 | Applied Psychology; Psychiatry and Mental Health | Medicine; Psychology | 2,000 |
10,824,656 | Six-month and 12-month mental health outcome of medical and surgical patients admitted to general hospital. | Psychological medicine | Psychol Med | 30 | 2 | 10.1017/s0033291799001804 | eng | 2,000 | 3 | null | null | null | null | [BACKGROUND] We have recently reported a two-phase study on psychiatric morbidity in a sample of general hospital patients. This paper reports the results of the 6-month and 12-month follow-up of these patients. [METHODS] The screening questionnaire was the GHQ-12. The main diagnostic instrument used in the second phas... | null | 3.018 | 251 | Applied Psychology; Psychiatry and Mental Health | Medicine; Psychology | 2,000 |
10,823,535 | Upper extremity fractures in restrained front-seat occupants. | The Journal of trauma | J Trauma | 48 | 5 | 10.1097/00005373-200005000-00015 | eng | 2,000 | 5 | null | null | null | null | [BACKGROUND] The aim of our study was to analyze the injury mechanism of upper extremity fractures in car crashes, to create a basis for developing prophylactic devices. [METHODS AND RESULTS] During 1985-1995, 3,260 restrained car drivers (1,228 front-seat passengers) were injured in 9,380 crashes involving cars. A tot... | null | null | null | null | null | null |
10,822,803 | High human plasma levels of organochlorine compounds in Greenland. Regional differences and lifestyle effects. | Danish medical bulletin | Dan Med Bull | 47 | 2 | null | eng | 2,000 | 4 | null | null | null | null | [INTRODUCTION] The purpose of the study has been to analyse data, collected for surveillance purposes under the Human Health Programme of AMAP (Arctic Monitoring and Assessment Programme, in Greenland, regarding geographical differences and lifestyle versus pollution load from persistent organic pollutants (POP), and t... | null | null | null | null | null | null |
10,822,404 | The effect of frequency and mode of sports activity on the psychological status in tetraplegics and paraplegics. | Spinal cord | Spinal Cord | 38 | 5 | 10.1038/sj.sc.3101002 | eng | 2,000 | 5 | null | null | null | null | [OBJECTIVE] To examine whether the psychological benefits of sports activity differ between tetraplegics and paraplegics with spinal cord injury, and investigate the effect of frequency and modes of sports activity on the psychological benefits. [METHODS] The Self-rating Depression Scale (SDS), State-Trait Anxiety Inve... | null | 0.733 | 131 | Medicine; Neurology; Neurology | Medicine; Neuroscience | 2,000 |
10,821,542 | Surgical management of the atelectatic ear. | The American journal of otology | Am J Otol | 21 | 3 | 10.1016/s0196-0709(00)80038-1 | eng | 2,000 | 5 | null | null | null | null | [OBJECTIVE] The surgical management of the atelectatic ear is controversial because the natural course toward cholesteatoma development cannot be predicted, and hearing acuity remains normal until later in the disease course. Consequently, surgery is often delayed until there is a clear indication, such as hearing loss... | null | null | null | null | null | null |
10,820,364 | The annual report to the nation on the status of cancer, 1973-1997, with a special section on colorectal cancer. | Cancer | Cancer | 88 | 10 | 10.1002/(sici)1097-0142(20000515)88:10<2398::aid-cncr26>3.0.co;2-i | eng | 2,000 | 5 | 15 | null | null | null | [BACKGROUND] This annual report to the nation addresses progress in cancer prevention and control in the U.S. with a special section on colorectal cancer. This report is the joint effort of the American Cancer Society, the National Cancer Institute (NCI), the North American Association of Central Cancer Registries (NAA... | null | 1.528 | 349 | Cancer Research; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,000 |
10,820,362 | T-cell-rich large B-cell lymphoma in children and adolescents: a clinicopathologic report of six cases from the Children's Cancer Group Study CCG-5961. | Cancer | Cancer | 88 | 10 | 10.1002/(sici)1097-0142(20000515)88:10<2378::aid-cncr24>3.0.co;2-q | eng | 2,000 | 5 | 15 | null | null | null | [BACKGROUND] T-cell-rich large B-cell lymphoma (TCRLBCL) is a morphologic subset of diffuse large B-cell lymphoma that has been confused with Hodgkin disease and reactive lymphadenopathies. To the authors' knowledge the majority of reports of TCRLBCL are from adults, and it is not widely recognized as occurring in the ... | null | 1.528 | 349 | Cancer Research; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,000 |
10,819,864 | Neonatal alloimmune thrombocytopenia: antenatal management. | American journal of obstetrics and gynecology | Am J Obstet Gynecol | 182 | 5 | 10.1067/mob.2000.104841 | eng | 2,000 | 5 | null | null | null | null | [OBJECTIVE] The optimal management of pregnancies at risk for neonatal alloimmune thrombocytopenia is debated. Proposed management includes the administration of intravenous immunoglobulin and serial determination of the fetal platelet count. The aims of our study were to determine the effectiveness and likely mechanis... | null | 1.624 | 274 | Obstetrics and Gynecology | Medicine | 2,000 |
10,819,364 | Significance of multiple nodal basin drainage in truncal melanoma patients undergoing sentinel lymph node biopsy. | Annals of surgical oncology | Ann Surg Oncol | 7 | 4 | 10.1007/s10434-000-0256-x | eng | 2,000 | 5 | null | null | null | null | [BACKGROUND] Although previous studies have demonstrated that truncal site is associated with an adverse prognosis, explanations for such risk are lacking. In addition, the number of nodal basins as well as the number of lymph nodes containing regional metastases are important prognostic factors in these patients. Beca... | null | 1.158 | 210 | Oncology; Surgery | Medicine | 2,000 |
10,819,252 | Informed consent in neurosurgery: patients' recall of preoperative discussion. | Acta neurochirurgica | Acta Neurochir (Wien) | 142 | 3 | 10.1007/s007010050030 | eng | 2,000 | null | null | null | null | null | [OBJECTIVE] Informed consent (IC) is an important principle of modern medicine and the quality of the process is likely to receive increasing attention in future due to complex surgical procedures and a development of social mistrust for medical treatment. Medico-legal action is also becoming an important influence on ... | Empirical Approach; Professional Patient Relationship | 0.555 | 112 | Neurology; Surgery | Medicine | 2,000 |
10,819,067 | A new method of intrathecal PO2, PCO2, and pH measurements for continuous monitoring of spinal cord ischemia during thoracic aortic clamping in pigs. | Surgery | Surgery | 127 | 5 | 10.1067/msy.2000.105036 | eng | 2,000 | 5 | null | null | null | null | [BACKGROUND] Impaired spinal cord circulation during thoracic aortic clamping may result in paraplegia. Reliable and fast responding methods for intraoperative monitoring are needed to facilitate the evaluation of protective measures and efficiency of revascularization. [METHODS] In 11 pigs, a multiparameter PO2, PCO2,... | null | null | null | null | null | null |
10,818,121 | Factors explaining the geographical differences in Disability Free Life Expectancy in Spain. | Journal of epidemiology and community health | J Epidemiol Community Health | 54 | 6 | 10.1136/jech.54.6.451 | eng | 2,000 | 6 | null | null | null | null | [OBJECTIVE] To study the geographical variations in Disability Free Life Expectancy (DFLE) at birth (DFLEb) and at 65 years (DFLE65) in Spain and to identify the main factors that explain these variations. [DESIGN] Ecological study with the 50 provinces of Spain as the units of analysis. Sullivan's method is used to ca... | null | 1.134 | 199 | Public Health, Environmental and Occupational Health; Epidemiology | Medicine | 2,000 |
10,817,564 | Gene therapy that inhibits nuclear translocation of nuclear factor kappaB results in tumor necrosis factor alpha-induced apoptosis of human synovial fibroblasts. | Arthritis and rheumatism | Arthritis Rheum | 43 | 5 | 10.1002/1529-0131(200005)43:5<1094::AID-ANR20>3.0.CO;2-V | eng | 2,000 | 5 | null | null | null | null | [OBJECTIVE] Tumor necrosis factor alpha (TNFalpha) increases the survival and proliferation of human rheumatoid arthritis (RA) cell lines. These experiments were designed to determine if inhibition of nuclear factor kappaB (NF-kappaB) nuclear translocation leads to increased apoptosis of TNFalpha-treated human RA cell ... | null | null | null | null | null | null |
10,816,626 | Single-layer continuous versus two-layer interrupted intestinal anastomosis: a prospective randomized trial. | Annals of surgery | Ann Surg | 231 | 6 | 10.1097/00000658-200006000-00007 | eng | 2,000 | 6 | null | null | null | null | [OBJECTIVE] To determine the suitability of a single-layer continuous technique for intestinal anastomosis in a surgical training program. [SUMMARY BACKGROUND DATA] Several recent reports have advocated the use of a continuous single-layer technique for intestinal anastomosis. Purported advantages include shorter time ... | null | 3.51 | 360 | Surgery | Medicine | 2,000 |
10,815,368 | An economic framework for evaluating a multileaf collimator. | International journal of technology assessment in health care | Int J Technol Assess Health Care | 16 | 1 | 10.1017/s0266462300161203 | eng | 2,000 | null | null | null | null | null | [OBJECTIVES] As health care budgets continue to face close scrutiny, any new acquisition must be evaluated for both costs and outcomes. This study was undertaken to demonstrate the application of an economic framework for the evaluation of a multileaf collimator as an example of a new technology that can have both quan... | null | 0.554 | 79 | Health Policy | Medicine | 2,000 |
10,815,134 | Stereotaxic injection of IgG from patients with Alzheimer disease initiates injury of cholinergic neurons of the basal forebrain. | Archives of neurology | Arch Neurol | 57 | 5 | 10.1001/archneur.57.5.681 | eng | 2,000 | 5 | null | null | null | null | [CONTEXT] The participation of an immune/inflammatory process in the pathomechanism of sporadic Alzheimer disease (AD) has been suggested by evidence for activated microglia and the potential therapeutic benefit of anti-inflammatory medication. [OBJECTIVE] To define a possible role for IgG in the immune/inflammatory pr... | null | null | null | null | null | null |
10,814,660 | Validity of rapid estimates of household wealth and income for health surveys in rural Africa. | Journal of epidemiology and community health | J Epidemiol Community Health | 54 | 5 | 10.1136/jech.54.5.381 | eng | 2,000 | 5 | null | null | null | null | [STUDY OBJECTIVE] To test the validity of proxy measures of household wealth and income that can be readily implemented in health surveys in rural Africa. [DESIGN] Data are drawn from four different integrated household surveys. The assumptions underlying the choice of wealth proxy are described, and correlations with ... | null | 1.134 | 199 | Public Health, Environmental and Occupational Health; Epidemiology | Medicine | 2,000 |
10,813,119 | Laparostomy for severe intra-abdominal infection complicating colorectal disease. | Diseases of the colon and rectum | Dis Colon Rectum | 43 | 1 | 10.1007/BF02237239 | eng | 2,000 | 1 | null | null | null | null | [PURPOSE] The aim of this study was to evaluate the use of laparostomy in the management of patients with severe intra-abdominal infection resulting from colorectal disease. [METHODS] Seven patients, four with inflammatory bowel disease, two with colorectal carcinoma, and one with diverticular perforation, underwent la... | null | 1.294 | 185 | Gastroenterology; Medicine | Medicine | 2,000 |
10,812,491 | Diffuse idiopathic skeletal hyperostosis (DISH): is it of vascular aetiology? | Clinical and experimental rheumatology | Clin Exp Rheumatol | 18 | 2 | null | eng | 2,000 | null | null | null | null | null | [OBJECTIVE] Reassessment of the pathological features of spinal involvement in DISH and studying the possible aetiopathogenetic mechanism/s of DISH in view of clinical, radiological and pathological findings. [METHODS] Forty Egyptian patients with DISH were included in this study. They underwent clinical and radiologic... | null | 0.56 | 112 | Immunology and Allergy; Rheumatology; Immunology | Immunology and Microbiology; Medicine | 2,000 |
10,811,546 | Chair and bed rise performance in ADL-impaired congregate housing residents. | Journal of the American Geriatrics Society | J Am Geriatr Soc | 48 | 5 | 10.1111/j.1532-5415.2000.tb04999.x | eng | 2,000 | 5 | null | null | null | null | [OBJECTIVES] To examine the ability of activity of daily living (ADL)-impaired older adults to successfully rise, and, when successful, the time taken to rise, from a bed and chair under varying rise task demands. [SETTING] Seven congregate housing facilities [SUBJECTS] Congregate housing residents (n = 116, mean age 8... | null | 1.823 | 273 | Geriatrics and Gerontology | Medicine | 2,000 |
10,811,494 | Proposing phase I studies: patients', relatives', nurses' and specialists' perceptions. | Annals of oncology : official journal of the European Society for Medical Oncology | Ann Oncol | 11 | 3 | 10.1023/a:1008393031299 | eng | 2,000 | 3 | null | null | null | null | [PURPOSE] As of now the primary objective of studies on informed consent in phase I trials has been to assess patients' expectations and reasons for participation. We have previously shown that the quantity of information provided through a procedure of subsequent oral interviews with patients was adequate while the at... | Biomedical and Behavioral Research; Empirical Approach | 1.005 | 311 | Hematology; Medicine; Oncology | Medicine | 2,000 |
10,811,078 | Highly active antiretroviral therapy-related immune recovery in AIDS patients with cytomegalovirus retinitis. | Ophthalmology | Ophthalmology | 107 | 5 | 10.1016/s0161-6420(00)00023-3 | eng | 2,000 | 5 | null | null | null | null | [OBJECTIVE] To characterize cytomegalovirus (CMV) retinitis in human immunodeficiency virus (HIV)-infected patients who demonstrate immune recovery while receiving highly active antiretroviral therapy (HAART). [DESIGN] Consecutive, noncomparative case series. [PARTICIPANTS] Twenty-two HIV-positive patients, from two in... | null | 2.651 | 297 | Ophthalmology | Medicine | 2,000 |
10,811,045 | Cost-minimisation analysis of three conservative treatment programmes in 180 patients sick-listed for acute low-back pain. | Scandinavian journal of primary health care | Scand J Prim Health Care | 18 | 1 | 10.1080/02813430050202578 | eng | 2,000 | 3 | null | null | null | null | [OBJECTIVE] To perform a cost-minimization analysis of three conservative treatment regimes for acute low-back pain (LBP). [DESIGN] A prospective randomized clinical trial. Patients were assigned at random to one of three treatment programmes: General Practitioner Programme (GPP-) controls, Manual Therapy Programme (MT... | null | 0.581 | 63 | Public Health, Environmental and Occupational Health | Medicine | 2,000 |
10,811,043 | Randomised, double blind, placebo controlled trial of penicillin V in the treatment of acute maxillary sinusitis in adults in general practice. | Scandinavian journal of primary health care | Scand J Prim Health Care | 18 | 1 | 10.1080/02813430050202550 | eng | 2,000 | 3 | null | null | null | null | [OBJECTIVE] To compare the effectiveness of penicillin V with placebo in the treatment of adult patients with acute maxillary sinusitis in general practice. [DESIGN] Randomised, double blind, placebo controlled trial. [SETTING] 26 Danish general practices. [PATIENTS] 133 adult patients with a clinical diagnosis of acut... | null | 0.581 | 63 | Public Health, Environmental and Occupational Health | Medicine | 2,000 |
10,810,411 | Serrated adenoma: a clinicopathological, DNA ploidy, and immunohistochemical study. | Anticancer research | Anticancer Res | 20 | 2B | null | eng | 2,000 | null | null | null | null | null | [AIMS] Serrated adenoma (SA) is a relatively newly defined entity of colorectal neoplasm. In this study, we examined the cell proliferation, DNA ploidy, and clinicopathological features of SA in order to investigate its biological features. [METHODS AND RESULTS] We reviewed 10,532 polypectomy specimens of the colorectu... | null | null | null | null | null | null |
10,810,167 | Detection and genotyping of Borrelia burgdorferi sensu lato by polymerase chain reaction. | Croatian medical journal | Croat Med J | 41 | 1 | null | eng | 2,000 | 3 | null | null | null | null | [AIM] To isolate and genotype Borrelia burgdorferi genospecies in serum samples of Croatian patients with erythema migrans. [METHODS] DNA isolates from sera of patients with erythema migrans were analyzed by nested polymerase chain reaction (PCR), amplifying a segment of flagellin gene with primers encompassing the con... | null | null | null | null | null | null |
10,810,108 | Prevalence and pattern of occupational exposure to whole body vibration in Great Britain: findings from a national survey. | Occupational and environmental medicine | Occup Environ Med | 57 | 4 | 10.1136/oem.57.4.229 | eng | 2,000 | 4 | null | null | null | null | [OBJECTIVES] To estimate the number of workers in Great Britain with significant occupational exposure to whole body vibration (WBV) and to identify the common sources of exposure and the occupations and industries where such exposures arise. [METHODS] A postal questionnaire was posted to a random community sample of 2... | null | 1.509 | 167 | Public Health, Environmental and Occupational Health | Medicine | 2,000 |
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