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The main question it aims to assess is will patient response to IL-23 therapies improve when simultaneously treated with fluconazole. conditions: Crohn's Disease conditions: Inflammatory Bowel Diseases studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT ... |
<|newrecord|> nctId: NCT06274541 id: CTRIAL-IE 18-01 briefTitle: Upfront Systematic Tumour BRCA Testing in Patients With High Grade Serous or Endometrioid Ovarian, Fallopian Tube or Primary Peritoneal Cancer (HGSEC): The t-BRCA Study overallStatus: ACTIVE_NOT_RECRUITING date: 2019-03-22 date: 2025-11 date: 2025-11 date... |
<|newrecord|> nctId: NCT06274528 id: 202301150 briefTitle: DORA and LP in Alzheimer's Disease Biomarkers overallStatus: RECRUITING date: 2024-03-11 date: 2029-03-11 date: 2029-03-11 date: 2024-02-23 date: 2024-03-29 name: Washington University School of Medicine class: OTHER briefSummary: The purpose of this study is t... |
<|newrecord|> nctId: NCT06274515 id: WO44977 briefTitle: A Study to Investigate Mechanisms of Resistance to Breast Cancer Therapies acronym: REMERGE overallStatus: RECRUITING date: 2024-04-02 date: 2027-01-28 date: 2027-01-28 date: 2024-02-23 date: 2024-04-08 name: Hoffmann-La Roche class: INDUSTRY briefSummary: This s... |
<|newrecord|> nctId: NCT06274502 id: deep learning briefTitle: Automated Detection and Diagnosis of Pathological DRGs in PHN Patients Using Deep Learning and Magnetic Resonance overallStatus: COMPLETED date: 2023-10-01 date: 2024-01-31 date: 2024-01-31 date: 2024-02-23 date: 2024-03-06 name: Huazhong University of Scie... |
<|newrecord|> nctId: NCT06274489 id: GSN000500 briefTitle: A Study to Evaluate Setanaxib in Patients With Alport Syndrome overallStatus: RECRUITING date: 2023-11-27 date: 2025-01-27 date: 2025-01-27 date: 2024-02-23 date: 2024-04-05 name: Calliditas Therapeutics AB class: INDUSTRY briefSummary: The purpose of the study... |
Setanaxib is planned for use together with the current standard of care to hopefully provide additional therapeutic benefits by preserving kidney function. |
The study will be conducted at multiple research sites in the UK, Spain, and Czech Republic. Eligible participants will be randomly assigned to receive either setanaxib or placebo. Setanaxib dose level will depend on age and all participants will receive their standard of care in addition to setanaxib or placebo. The s... |
<|newrecord|> nctId: NCT06274476 id: 2020/9/9 briefTitle: Prosthetic Rehabilitation of Thin Wiry Ridge by Ridge Splitting and Simultaneous Implants Placement acronym: implant overallStatus: COMPLETED date: 2018-09-09 date: 2019-12-09 date: 2020-01-01 date: 2024-02-23 date: 2024-02-23 name: Cairo University class: OTHER... |
<|newrecord|> nctId: NCT06274463 id: 2023-11-035 briefTitle: A Personalized Trunk Stability Exercise Program Study With Brain Disease Patients overallStatus: NOT_YET_RECRUITING date: 2024-02-21 date: 2024-12-31 date: 2024-12-31 date: 2024-02-23 date: 2024-02-23 name: Bundang CHA Hospital class: OTHER briefSummary: To i... |
<|newrecord|> nctId: NCT06274450 id: C2202112 briefTitle: A Clinical Study on the Improvement of Skin and Living Conditions After Drinking Rosa Roxburghii and Pomegranate Drinks overallStatus: COMPLETED date: 2022-07-06 date: 2022-09-02 date: 2022-09-02 date: 2024-02-23 date: 2024-02-23 name: Botanee Group Co., Ltd. cl... |
This is a single-center, randomized, single-blind, controlled, 8-week (56-day) clinical study conducted in Chinese healthy women aged 25-45 years old who were offered a rosa roxburghii and pomegranate drink. conditions: Skin Laxity studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL ... |
<|newrecord|> nctId: NCT06274437 id: BND-35-001 briefTitle: A Study of BND-35 in Participants With Advanced Solid Tumors overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-09 date: 2027-11 date: 2024-02-23 date: 2024-02-23 name: Biond Biologics class: INDUSTRY briefSummary: This is an open-label, multicenter, d... |
<|newrecord|> nctId: NCT06274424 id: HUS/211/2016 and HUS/2699/2018 briefTitle: Hair Cortisol and Symptoms in Children With Psychopathology During CBT overallStatus: COMPLETED date: 2016-07-01 date: 2019-10-01 date: 2019-10-01 date: 2024-02-23 date: 2024-02-29 name: Helsinki University Central Hospital class: OTHER bri... |
<|newrecord|> nctId: NCT06274411 id: KS2024014 briefTitle: Standby Cannulated ECMO for High-Risk Percutaneous Coronary Intervention acronym: ESCORT overallStatus: RECRUITING date: 2024-03-01 date: 2025-12-31 date: 2026-03-01 date: 2024-02-23 date: 2024-02-23 name: Beijing Anzhen Hospital class: OTHER briefSummary: The ... |
• If standby cannulated ECMO as compared with prophylactic ECMO will improve the outcomes in patients undergoing high-risk PCI conditions: ECMO conditions: High-risk PCI studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPA... |
<|newrecord|> nctId: NCT06274398 id: RITE Study briefTitle: Rectal Insert TAF/EVG Pre-Exposure Prophylaxis (RITE PrEP) Study acronym: RITE PrEP overallStatus: RECRUITING date: 2024-01-16 date: 2024-10-31 date: 2024-12-31 date: 2024-02-23 date: 2024-02-23 name: Eastern Virginia Medical School class: OTHER name: CONRAD n... |
<|newrecord|> nctId: NCT06274385 id: 2311010178 briefTitle: The Effects of an Acute Dose of a Betalain-rich Concentrate on Repeated-sprint Cycling Performance and Recovery. acronym: BET_RSE overallStatus: RECRUITING date: 2024-02 date: 2024-06 date: 2024-06 date: 2024-02-23 date: 2024-02-23 name: Drexel University clas... |
<|newrecord|> nctId: NCT06274372 id: FCV,V-2202 briefTitle: The Effect of Flow-controlled Ventilation on Hemodynamic and Respiratory Parameters in Laparoscopic Surgeries overallStatus: ACTIVE_NOT_RECRUITING date: 2023-08-07 date: 2024-08-06 date: 2024-08-06 date: 2024-02-23 date: 2024-03-06 name: Derince Training and R... |
<|newrecord|> nctId: NCT06274359 id: 21-3985 briefTitle: Digital Storytelling to Reduce Pediatric Influenza Vaccination Disparities overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-03-31 date: 2027-08-31 date: 2024-02-23 date: 2024-02-23 name: Denver Health and Hospital Authority class: OTHER briefSummary:... |
<|newrecord|> nctId: NCT06274346 id: ahmedU briefTitle: Effect of Retro Walking Versus Isometric Multi-angular Exercises on Pain and Functional Performance in Knee Osteoarthritis in Geriatric Population overallStatus: COMPLETED date: 2023-06-01 date: 2023-11-10 date: 2023-11-30 date: 2024-02-23 date: 2024-02-23 name: D... |
The common clinical manifestations of knee OA include pain, stiffness, joint enlargement, crepitus, muscle weakness, deformity, impaired proprioception, reduced joint motion, and disability(3). |
Patients with knee Osteoarthritis seems to develop their own gait pattern and try to unload the affected structures during gait. More over patients with less severe knee osteoarthritis develop a gait pattern that differs from patients with severe osteoarthritis and control group of patients (4). |
Isometric exercises are types of strength training in which the joint angle and muscle length do not change during contraction, and therefore this approach can be advantageous in the early stages of knee rehabilitation in cases where the range of motion is restricted due to pain (13). No physical work is performed duri... |
Another study was conducted to assess the effectiveness of Isometric exercise and counseling on level of pain among patients with Knee osteoarthritis, the authors concluded that Isometric exercise and counseling program has significantly reduced pain, stiffness and improved physical function and the authors recommended... |
Materials and Methods |
This randomized controlled experimental trial was carried out at the outpatient clinic of faculty of physical therapy, Delta University for science and technology from June 2023 to November 2023. The aims of the study and the study protocol were explained for each patient before participation in the study. All patients... |
Subjects: |
Sixty male and female geriatric patients had chronic knee osteoarthritis were chosen the outpatient clinic of faculty of physical therapy, Delta University for science and technology. In each case, the diagnosis of knee OA was based on the criteria specified by the American College of Rheumatology. |
We recorded the height, weight, and medical history, and lower extremity dominance, level of education, occupation and duration of complaints of each patient. All were evaluated at the beginning of the treatment (week 0), at the endpoint of the treatment (week 4) conditions: Knee Osteoarthritis studyType: INTERVENTIONA... |
<|newrecord|> nctId: NCT06274333 id: RC.18.1.2024 briefTitle: Adding Dexmedetomidine or Tramadol to Paracetamol- An Effort to Attenuate Catheter Related Bladder Discomfort overallStatus: RECRUITING date: 2024-02-28 date: 2024-05-30 date: 2024-05-30 date: 2024-02-23 date: 2024-03-15 name: Al-Azhar University class: OTHE... |
<|newrecord|> nctId: NCT06274320 id: LRP22002 LIPIKAR UREA 30% briefTitle: Effect of Lipikar Urea 30% Before Actinic Keratoses Treatment overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-10 date: 2024-10 date: 2024-02-23 date: 2024-02-28 name: Cosmetique Active International class: INDUSTRY briefSummary: This ... |
<|newrecord|> nctId: NCT06274307 id: IRB-21-10-4045 briefTitle: Efficacy of Transversus Abdominis Plane Block overallStatus: RECRUITING date: 2023-06-22 date: 2024-07-01 date: 2024-09-01 date: 2024-02-23 date: 2024-02-23 name: Justin Hruska class: OTHER briefSummary: This study aims to assess the efficacy of Transversu... |
<|newrecord|> nctId: NCT06274294 id: 2023/12 briefTitle: Pharmacokinetics, Efficacy and Safety of CT-P13 Subcutaneous as Induction Therapy in Patients With Active CD or UC acronym: PASSPORT overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-01 date: 2025-01 date: 2024-02-23 date: 2024-02-23 name: CMC Ambroise P... |
The main aim of this study is to demonstrate that induction treatment with CT-P13 SC is non-inferior to CT-P13 IV in terms of pharmacokinetics at Week 6. conditions: Inflammatory Bowel Diseases studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The ... |
* Experimental Arm: Patients receive CT-P13 SC at weeks 0, 1, 2, 3, 4, and 6, followed by subcutaneous administration every two weeks until week 24. |
* Control Arm: Patients receive CT-P13 IV at weeks 0 and 2, followed by subcutaneous administration every two weeks until week 24. primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 130 type: ESTIMATED name: CT-P13 measure: Ratio SC/IV measure: Ctrough at week 24 (non-inferiority) measure: AUC at w... |
<|newrecord|> nctId: NCT06274281 id: TOMs_FMD briefTitle: Digital Telerehabilitation in Functional Motor Disorders overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-02-01 date: 2026-02-01 date: 2024-02-23 date: 2024-02-23 name: Universita di Verona class: OTHER briefSummary: Functional motor disorders (FMDs... |
The increasing development and availability of portable and wearable technologies are rapidly expanding the field of technology-based objective measures (TOMs) in neurological disorders. However, substantial challenges remain in (1) recognizing TOMs relevant to patients and clinicians to provide accurate, objective, an... |
This feasibility study provides preliminary data on the integration of a real-time gait and activity analysis by wearable devices in the real world with a digital platform to improve the diagnosis, monitoring, and rehabilitation of patients with FMDs. conditions: Functional Movement Disorder studyType: INTERVENTIONAL p... |
<|newrecord|> nctId: NCT06274268 id: CHMS23006 briefTitle: Effect of Sarcopenia on the Occurrence of Toxicity Related to Anti-cancer Treatments acronym: SARC-ONCO overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2027-05-01 date: 2028-05-01 date: 2024-02-23 date: 2024-02-23 name: Centre Hospitalier Metropole Sav... |
The main question it aims to answer is : |
Is sarcopenia a predictive marker for the occurrence of toxicity in the initial phase of cancer treatment? |
The evaluation will focus on the body composition of the participants, assessed by impedancemetry, and on their muscular performance by standardized physical tests. conditions: Sarcopenia conditions: Oncology conditions: Physical Inactivity conditions: Toxicity Due to Chemotherapy studyType: INTERVENTIONAL phases: NA a... |
<|newrecord|> nctId: NCT06274255 id: BalikesirU briefTitle: Serum Magnesium Level and Pediatric Migraine acronym: Migraine overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-04-10 date: 2024-05-15 date: 2024-02-23 date: 2024-02-23 name: Mersin University class: OTHER briefSummary: Aim: The purpose of this st... |
Material-Method: Patients diagnosed presenting to the Balıkesir University Medical Faculty pediatric neurology clinic between 01.09.2019 and 01.04.2023 and diagnosed with migraine were enrolled retrospectively. Patients diagnosed with migraine were included as the study group and healthy children presenting to the pedi... |
<|newrecord|> nctId: NCT06274242 id: MU-CIRB 2022/300.0711 briefTitle: Mixed Natural Prebiotic-Fibers Impact on Stool Frequency and Fecal Microbiota in Constipated Thai Adults overallStatus: ACTIVE_NOT_RECRUITING date: 2023-03-10 date: 2023-07-22 date: 2024-04-19 date: 2024-02-23 date: 2024-02-23 name: Mahidol Universi... |
<|newrecord|> nctId: NCT06274229 id: EA4/252/23 briefTitle: DivAirCity Social Health Survey acronym: DivAirCitySH overallStatus: RECRUITING date: 2024-02-20 date: 2024-12-31 date: 2025-12-31 date: 2024-02-23 date: 2024-02-23 name: Charite University, Berlin, Germany class: OTHER name: Universitat Politècnica de Valènci... |
<|newrecord|> nctId: NCT06274216 id: 4381021ABOS briefTitle: The Effect of Vitamin D Supplementation on Dental Implant Osseointegration: A Randomized Controlled Trial overallStatus: COMPLETED date: 2021-09-01 date: 2022-03-30 date: 2022-04-01 date: 2024-02-23 date: 2024-02-23 name: Ziauddin University class: OTHER brie... |
Prior to implant surgery, each participant undergoes a blood test to assess their vitamin D levels. |
Detailed records are maintained concerning the anatomical position (molar, pre-molar, canine, and incisor) and implant site (maxilla and mandible) for every participant. |
Group Formation: The participant pool is stratified into two distinct groups - Group A and Group B. This categorization is essential for implementing and comparing different interventions within the study. Group A undergoes a specific intervention wherein they receive a daily oral dose of 5000 IU of vitamin D3 for a du... |
Following the intervention period, the implants are allowed to cure adequately primaryPurpose: SUPPORTIVE_CARE masking: DOUBLE maskingDescription: Groups A and B were created out of all patients who had signed up. Patients in group A received 5000 IU of vitamin D3 orally every day for 12 weeks , whereas patients in gro... |
The both groups were compared for the difference of osseo-integration at 3 months, as well as difference of osseo-integration were compared with respect to implant site (maxilla and mandible). |
Additionally, change in vitamin D levels were also assessed pre-operatively and post-operatively at 3 months. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER count: 100 type: ACTUAL name: Vitamin D3 name: Vitamin E 400 measure: Osseo-integration is measured by evaluating the ISQ value (Implant Stability Quotient, rangi... |
<|newrecord|> nctId: NCT06274203 id: 10584-2/5-2023 briefTitle: High Dose Vitamin D Supplementation in Children With Sickle Cell Disease overallStatus: COMPLETED date: 2023-05-03 date: 2024-01-30 date: 2024-02-10 date: 2024-02-23 date: 2024-02-23 name: Zagazig University class: OTHER_GOV briefSummary: Suboptimal vitami... |
<|newrecord|> nctId: NCT06274190 id: S68746 briefTitle: Personalized Care Pathways for Bowel Symptoms in Rectal Cancer patients_development of E-diary acronym: Treatable overallStatus: NOT_YET_RECRUITING date: 2024-04-29 date: 2025-10 date: 2026-03 date: 2024-02-23 date: 2024-04-08 name: KU Leuven class: OTHER name: Un... |
<|newrecord|> nctId: NCT06274177 id: BTL-785_CTUS1400 briefTitle: Evaluation of the BTL-785F Device for Submental Fat Reduction and Neck Rejuvenation overallStatus: ACTIVE_NOT_RECRUITING date: 2023-07-26 date: 2024-04-01 date: 2024-04-01 date: 2024-02-23 date: 2024-02-23 name: BTL Industries Ltd. class: INDUSTRY briefS... |
<|newrecord|> nctId: NCT06274164 id: H-54820 / RAI1 briefTitle: Clinical and Molecular Biomarker Studies in RAI1 (Retinoic Acid-Induced 1) -Related Disorders overallStatus: RECRUITING date: 2024-03-13 date: 2027-03 date: 2027-03 date: 2024-02-23 date: 2024-04-01 name: Baylor College of Medicine class: OTHER name: Doris... |
Biomarkers can help doctors and scientists diagnose diseases and health conditions, monitor responses to treatment and see how a person's disease or health condition changes over time. |
The goal of this observational and laboratory study is to develop clinical, neurophysiology and molecular biomarkers in RAI1-related disorders. The main question\[s\] it aims to answer are: |
* to characterize the disease features more precisely and analyze the differentiating and overlapping features of RAI1-related disorders (Smith-Magenis syndrome and Potocki-Lupski Syndrome) |
* to identify clinical, neurophysiology, and laboratory biomarkers that differentiate RAI1-related disorders one from another. |
Participants will have to complete: |
* a clinical examination |
* a blood draw |
* a skin biopsy (optional) |
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