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<|newrecord|> nctId: NCT06383338 id: PEGASUS briefTitle: A Study Investigating the Change in Metabolism Phenotype in Paediatric, Adolescent & Young Adults With Hodgkin or Non-Hodgkin Lymphoma. acronym: PEGASUS overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-05 date: 2026-05 date: 2024-04-25 date: 2024-04-25 ... |
The study involves administration of the probe medication at timepoints which align with pre-determined hospital visits for the treatment of lymphoma and subsequent blood draws to measure the metabolism of the probe medications. |
The acceptability and feasibility of this study will inform future studies in phenoconversion within the paediatric cancer population to direct more personalised precision medicine. conditions: Hodgkin Lymphoma conditions: Non Hodgkin Lymphoma studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interven... |
<|newrecord|> nctId: NCT06383325 id: Livertoxcicity in AL briefTitle: Livertoxcicity in Acute Leukemia Patients During Chemotherapy Treatment overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-05-01 date: 2025-08-01 date: 2024-04-25 date: 2024-04-25 name: Assiut University class: OTHER briefSummary: Detectio... |
<|newrecord|> nctId: NCT06383312 id: E-10840098-772.02-4248 briefTitle: Magnetic Reflexologic Insoles for Primary Dysmenorrhea overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-08 date: 2024-09 date: 2024-04-25 date: 2024-04-25 name: Istanbul Medipol University Hospital class: OTHER briefSummary: In the study,... |
<|newrecord|> nctId: NCT06383299 id: AnkaraYbuMNC briefTitle: The Validity and Reliability Study of Turkish Version of Calgary Sleep Apnea Quality of Life Index overallStatus: COMPLETED date: 2021-01-01 date: 2021-07-01 date: 2021-08-01 date: 2024-04-25 date: 2024-04-25 name: Ankara Yildirim Beyazıt University class: O... |
<|newrecord|> nctId: NCT06383286 id: AnkaraYBUfby briefTitle: The Relationship Between Physical Activity Levels and Anxiety, Depression, Stress of Disabled Athletes overallStatus: COMPLETED date: 2020-12-01 date: 2021-03-01 date: 2022-03-01 date: 2024-04-25 date: 2024-04-25 name: Ankara Yildirim Beyazıt University clas... |
<|newrecord|> nctId: NCT06383273 id: MELT-3-001 briefTitle: A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR) overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-12 date: 2025-01 date: 2024-04-25 date: 2024-04-25 na... |
The main questions it aims to answer are: |
1. Does MELT-300 is effective in comparison to placebo on procedural sedation for cataract surgery? |
2. To determine the effectiveness of MELT-300 compared with midazolam on procedural sedation (to determine the contribution of ketamine component and inform the risk of ketamine in MELT-300) |
3. To determine the time to achieve preoperative target sedation level with MELT-300 |
4. What medical problems do participants have when taking MELT-300 vs placebo |
Eligible participants will admitted to the study unit on Day 1. Participants will be randomized prior to surgery 4:1:1 to |
1. MELT-300 (i.e. 1 MELT-300 sublingual tablet which contains 3 mg midazolam and 50 mg of ketamine) |
2. Midazolam (i.e. 1 matching midazolam sublingual tablet which contains 3 mg midazolam) |
3. Placebo (i.e. 1 matching placebo sublingual tablet) |
Participants will receive study medication 30 (± 5) minutes, without food or water, before planned surgery start (defined as instillation of topical ocular anesthetic gel \[i.e.. 3 drops of chloroprocaine hydrochloride ophthalmic gel)\]. |
The effectiveness of MELT-300 will be performed after study medication is administered before surgery, in the course of surgery, and postoperative on Day 1 (end of surgery defined as just prior to drape removal). The safety of MELT-300 will be performed at baseline, in the course of surgery, postoperatively on Day 1, a... |
<|newrecord|> nctId: NCT06383260 id: 009-0001-7719-1189 briefTitle: Assessing the Prevalence of Attention Deficit Hyperactivity Disorder (ADHD) Symptoms in Undiagnosed Young Adults:A Cross Sectional Study overallStatus: COMPLETED date: 2023-07-01 date: 2023-09-01 date: 2023-09-01 date: 2024-04-25 date: 2024-04-25 name:... |
<|newrecord|> nctId: NCT06383247 id: AMU-PD-multicenter briefTitle: The Efficacy of Repetitive Transcranial Magnetic Stimulation With Precision Neuronavigation in Parkinson's Disease overallStatus: NOT_YET_RECRUITING date: 2024-11-01 date: 2028-12-31 date: 2030-12-31 date: 2024-04-25 date: 2024-04-29 name: Anhui Medica... |
<|newrecord|> nctId: NCT06383234 id: PAR 89/21 briefTitle: REduced Pain After Bariatric Surgery - Sleeve Gastrectomy acronym: REPABS-SG overallStatus: COMPLETED date: 2022-01-10 date: 2023-09-21 date: 2023-09-28 date: 2024-04-25 date: 2024-04-25 name: Fondazione Policlinico Universitario Campus Bio-Medico class: OTHER ... |
<|newrecord|> nctId: NCT06383221 id: 83244570 briefTitle: Study of the Intervention Effect of Stepped-care Models on Depression Symptoms During Pregnancy. overallStatus: NOT_YET_RECRUITING date: 2024-05-20 date: 2025-10-20 date: 2026-03-10 date: 2024-04-25 date: 2024-04-25 name: Fangbiao Tao class: OTHER briefSummary: ... |
<|newrecord|> nctId: NCT06383208 id: 2024-ZF-13 briefTitle: Cardiovascular-Renal Adverse Prognosis Assessment System for Coronary Heart Disease With Chronic Kidney Disease Based on Metabolomics acronym: CRUISE-MET overallStatus: RECRUITING date: 2024-04-01 date: 2027-03-31 date: 2027-03-31 date: 2024-04-25 date: 2024-0... |
Furthermore, the emerging concept of "cardiovascular-kidney-metabolic syndrome" and the availability of new treatment options highlight the urgent need for a risk stratification tool tailored to modern management strategies and treatment goals to guide preventive measures effectively. To address this, we propose to con... |
<|newrecord|> nctId: NCT06383195 id: SBA 24/189 briefTitle: The Reliability and Validity of the Ankylosing Spondylitis Performance Index (ASPI) in Enthesitis-Related Arthritis overallStatus: RECRUITING date: 2024-03-21 date: 2026-03-20 date: 2026-03-20 date: 2024-04-25 date: 2024-04-25 name: Hacettepe University class:... |
<|newrecord|> nctId: NCT06383182 id: Y (2024) 054 briefTitle: Change in Serum Biomarkers After Endovascular Treatment for Acute Anterior Circulation Large Vessel Occlusion overallStatus: NOT_YET_RECRUITING date: 2024-05-07 date: 2026-12-30 date: 2026-12-30 date: 2024-04-25 date: 2024-04-25 name: General Hospital of She... |
<|newrecord|> nctId: NCT06383169 id: wanglizhong briefTitle: Impact of External Drainage of the Lumbar Cistern in Patients With Hydrocephalus Following Meningioma Surgery and Its Influence on Patient Satisfaction overallStatus: COMPLETED date: 2019-05-01 date: 2022-05-01 date: 2022-05-30 date: 2024-04-25 date: 2024-04-... |
<|newrecord|> nctId: NCT06383156 id: MD157/2023 briefTitle: The Use of Lung US, Fluoroscopy and Auscultation to Confirm Proper Positioning of Left Sided DLT : A Comparative Study overallStatus: NOT_YET_RECRUITING date: 2024-04-17 date: 2024-09-18 date: 2024-10-01 date: 2024-04-25 date: 2024-04-25 name: Ain Shams Univer... |
<|newrecord|> nctId: NCT06383143 id: AC-020-IT briefTitle: Promoting Diagnosis and Management of AL in Italy (ProDigALIty) acronym: ProDigALIty overallStatus: RECRUITING date: 2023-05-01 date: 2025-05-01 date: 2025-05-01 date: 2024-04-25 date: 2024-04-25 name: IRCCS Policlinico S. Matteo class: OTHER briefSummary: We p... |
1. Implement a biomarker-based screening strategy to promote early diagnosis of AL amyloidosis among at-risk patients, including patients with monoclonal gammopathy of undetermined significance, MGUS, and altered free light chain ratio (aFLCR), and patients with smoldering multiple myeloma (SMM) |
2. Expedite and facilitate patients' referral and their enrollment in ongoing pre-clinical/clinical studies, also to reflect a broader spectrum of the real-world population of patients with AL amyloidosis in Italy; |
3. Investigate the clinical utility of novel diagnostic technologies, including light chain sequencing and N-glycosylation analysis conditions: AL Amyloidosis conditions: Smoldering Multiple Myeloma conditions: Monoclonal Gammopathy of Undetermined Significance studyType: OBSERVATIONAL observationalModel: CASE_ONLY tim... |
<|newrecord|> nctId: NCT06383130 id: 24SM8792 briefTitle: London Asthma Diagnostics Study acronym: LADS overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-12 date: 2026-07 date: 2024-04-25 date: 2024-04-25 name: Imperial College London class: OTHER name: Asthma UK name: General Practitioners Research Institute ... |
- Does oscillometry with reversibility testing increase diagnostic accuracy in detection of asthma in adults when added to spirometry with reversibility and FeNO? |
Researchers will evaluate the diagnostic accuracy of this approach with the reference standard, which is a clinically adjudicated diagnosis of asthma by two respiratory clinicians based on history and investigation results. |
Participants will |
* Undergo oscillometry testing alongside their routine asthma investigations within their scheduled clinic visit |
* Optionally participate in our sub-studies on new breath and nasal swab tests for asthma |
* Optionally participate in our qualitative substudy on patients views and attitudes to asthma testing and oscillometry conditions: Asthma studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 225 type: ESTIMATED name: Oscillometry with reversibility testing name: Breath volatile testin... |
<|newrecord|> nctId: NCT06383117 id: UL1TR002378 type: NIH link: https://reporter.nih.gov/quickSearch/UL1TR002378 id: KL2TR002381 type: NIH link: https://reporter.nih.gov/quickSearch/KL2TR002381 briefTitle: Understanding Effects of Calcium on the Gut-Bone Axis overallStatus: COMPLETED date: 2023-10-17 date: 2024-02-23 ... |
Blood will be analyzed to check on various health indicators, like bone health markers and certain hormones, to see how they change after the meal. The difference in these health indicators between the calcium and placebo sessions will help the study team understand the impact of calcium on health after eating. This co... |
<|newrecord|> nctId: NCT06383104 id: MyoLupus briefTitle: Myofascial Techniques and Proprioceptive Neuromuscular Facilitation in Patients With Systemic Lupus Erythematosus. overallStatus: RECRUITING date: 2024-04-22 date: 2024-05-28 date: 2024-06-26 date: 2024-04-25 date: 2024-04-25 name: Universidad Católica San Anton... |
Objective. To analyse the efficacy of an intervention using myofascial techniques and proprioceptive neuromuscular facilitation in patients with systemic lupus erythematosus. |
Methods. Randomised clinical study with 20 patients with systemic lupus erythematosus, randomised to an experimental and control group. The intervention will last 4 weeks, with a periodicity of 2 weekly sessions of 50 minutes each. The intervention of the experimental group will consist of a protocol using myofascial a... |
Expected results. Improvement of knee and ankle pain intensity, functional capacity, basic mobility skills, strength, balance, agility and fatigue. conditions: System; Lupus Erythematosus studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: PREVENTION masking: SINGLE ... |
<|newrecord|> nctId: NCT06383091 id: IRB00380938 briefTitle: Impact of Manual Therapy on Laryngeal Function Following Total Thyroidectomy acronym: Man Total Thy overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-12 date: 2026-12 date: 2024-04-25 date: 2024-04-25 name: Johns Hopkins University class: OTHER brief... |
The main questions it aims to answer are: |
Will neck massage, stretches and pain science education reduce patient complaints of swallowing changes after total thyroidectomy? |
Will neck massage, stretches and pain science education reduce patient complaints of voice changes after total thyroidectomy? |
Will neck massage, stretches and pain science education reduce patient complaints of scar tethering and quality changes after total thyroidectomy? |
Will neck massage, stretches and pain science education improve quality of life after total thyroidectomy? |
Participants will: |
Participate in 4 visits with the participant's endocrine/laryngology surgeon. One prior and 3 after surgery for endoscopic evaluation and tests. |
Participate in 5 Speech-Language Pathology Sessions for intervention exercises and tests. One prior and 4 after surgery. |
Complete a journal of the participant's Home Exercise Practice conditions: Total Thyroidectomy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This is meant to be a parallel study. However, The Speech Language Pathologists will not be blinded as the ... |
<|newrecord|> nctId: NCT06383078 id: MA-PC-II-012 briefTitle: HR070803 in Combination With Oxaliplatin, S-1 Versus NALIRIFOX as Adjuvant Therapy for Pancreatic Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2027-03-01 date: 2027-12-30 date: 2024-04-25 date: 2024-04-25 name: The First Affiliated Hospita... |
<|newrecord|> nctId: NCT06383065 id: YDU/2020/76-1007 briefTitle: Respiratory Physiotherapy in Type 2 Diabetes and Bariatric Surgery overallStatus: COMPLETED date: 2020-02-01 date: 2021-04-30 date: 2022-01-30 date: 2024-04-25 date: 2024-04-25 name: Near East University, Turkey class: OTHER briefSummary: The aim of this... |
The study will be conducted with 40 individuals with type 2 diabetes aged between 25-65. Individuals will be randomly assigned to the IMT (trained at 30% of maximum inspiratory pressure with an IMT threshold device) and control group. As measurement parameters, a 6-minute walk test for functional capacity, a spirometry... |
<|newrecord|> nctId: NCT06383052 id: NYM032Z01 briefTitle: A Phase 1/2 Study of 177Lu-NYM032 Injection in mCRPC overallStatus: RECRUITING date: 2024-04-30 date: 2024-11-30 date: 2024-11-30 date: 2024-04-25 date: 2024-04-25 name: Norroy Bioscience Co., LTD class: INDUSTRY briefSummary: 177Lu-NYM032 injection is a radiol... |
<|newrecord|> nctId: NCT06383039 id: ZSoy briefTitle: Transcranial Direct Current Stimulation and Balance acronym: tDCS overallStatus: COMPLETED date: 2022-05-16 date: 2022-09-06 date: 2023-05-13 date: 2024-04-25 date: 2024-04-25 name: Zeynep Soy class: OTHER briefSummary: Postural control is an adaptive sensorimotor p... |
<|newrecord|> nctId: NCT06383026 id: PRO00047199 briefTitle: Transgender and Gender-Diverse Breast Cancer Screening Pilot overallStatus: RECRUITING date: 2024-04-17 date: 2027-12 date: 2028-02 date: 2024-04-25 date: 2024-04-25 name: Medical College of Wisconsin class: OTHER briefSummary: This investigation is a prospec... |
<|newrecord|> nctId: NCT06383013 id: BB-101-BBCBB1A briefTitle: Phase II Study of BB-101 for the Treatment of Diabetic Lower Leg and Foot Ulcers overallStatus: RECRUITING date: 2024-02-29 date: 2027-12-31 date: 2028-12-31 date: 2024-04-25 date: 2024-04-25 name: Blue Blood Biotech Corp. class: INDUSTRY briefSummary: Thi... |
<|newrecord|> nctId: NCT06383000 id: BLZ2024MOH briefTitle: Assessment of Effectiveness of Continuous Non-invasive Haemodynamic Monitor by Compared to Invasive Blood Pressure and Pulse Oximeter Monitoring on Patients Undergoing General Anesthesia Surgeries for More Than 60 Minutes overallStatus: NOT_YET_RECRUITING date... |
Researchers will compare blood pressure data derived from MOH200 to the invasive blood pressure (IBP) data to see if the MOH200 is effective to measure the blood pressure of a surgical person. Also, researchers will compare pulse rate data drived from MOH200 to that from the pulse oximeter to see if the MOH200 is effec... |
Participants will be asked to be applied with MOH200 monitoring while IBP monitoring and pulse oximeter are applied. And after 30 minutes of the surgery, researchers will monitor the adverse effects occurred on the skin of participants to assess the safety of MOH200. conditions: General Anesthesia conditions: Blood Pre... |
<|newrecord|> nctId: NCT06382987 id: IM011-1124 briefTitle: A Study of the Comparative Effectiveness of Deucravacitinib in Adults With Plaque Psoriasis in Japan (RePhlect) acronym: RePhlect overallStatus: RECRUITING date: 2024-01-22 date: 2029-12-31 date: 2029-12-31 date: 2024-04-25 date: 2024-04-25 name: Bristol-Myers... |
<|newrecord|> nctId: NCT06382974 id: 3-3-14 briefTitle: Evaluation of the Osteoinductivity of Atorvastatin Combined With β-TCP overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-12 date: 2026-03 date: 2024-04-25 date: 2024-04-25 name: Cairo University class: OTHER briefSummary: This case series study aims to ev... |
<|newrecord|> nctId: NCT06382961 id: SZUS_231101 briefTitle: Postoperative Dexmedetomidine in Prevention of Postoperative Delirium overallStatus: ACTIVE_NOT_RECRUITING date: 2023-11-11 date: 2024-03-06 date: 2024-04 date: 2024-04-25 date: 2024-04-25 name: Boston Intelligent Medical Research Center, Shenzhen United Sche... |
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