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Patients with head and neck cancer (H\&N-C) and Glioblastoma multiforme (GBM) have high psychological and sometimes psychiatric comorbidity probably due to the severity, poor prognosis of these cancers and harsh treatment toxicities. |
The most important protective factor for psychopathology is psychological resilience, which is "the capacity of a person to protect themselves and their mental health when facing life adversities," such as a GBM or H\&N-C diagnosis. Resilience is influenced by the affective temperament, which refers to basic personalit... |
To date, the literature does not clarify the role of resilience and temperament in mediating the psychological profile of cancer patients. Furthermore, extensive profiling of the psychological and psychiatric profile of these patients at such a critical and pivotal moment in their journey is currently lacking in the li... |
Aim of this study is to evaluate global psychological and psychiatric profile of patients affected by GBM and H\&N-C and the eventual fluctuation over time during RT course. Conducting an early and accurate screening for potential psychopathological issues will give the opportunity to avoid factors that could: worsen p... |
The results obtained will be utilized for planning precocious psychological or psychiatric take-in-charge aimed at promoting psychological well-being of H\&N-C and GBM patients. conditions: Glioblastoma conditions: Head and Neck Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE cou... |
<|newrecord|> nctId: NCT06385119 id: F8394-101 briefTitle: A Study of the Effects of Food and Cobicistat on Plixorafenib Pharmacokinetics in Healthy Volunteers. overallStatus: NOT_YET_RECRUITING date: 2024-04-24 date: 2024-10-31 date: 2024-11-25 date: 2024-04-25 date: 2024-04-25 name: Fore Biotherapeutics class: INDUST... |
* The effect of food on the single dose PK of plixorafenib administered with cobicistat. |
* The effect of cobicistat administration on the single dose PK of plixorafenib. |
* The safety of plixorafenib administered alone and with cobicistat in a single dose regimen in healthy participants. conditions: Healthy Volunteer studyType: INTERVENTIONAL phases: PHASE1 allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: NONE count: 12 type: ESTIMATED name: Pli... |
<|newrecord|> nctId: NCT06385106 id: rTMS in AD briefTitle: Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-12 date: 2025-01 date: 2024-04-25 date: 2024-04-25 name: First Affiliated Hospital of Zhejiang University cl... |
<|newrecord|> nctId: NCT06385093 id: EDR-IIS-003 briefTitle: A Study on the Prevention and Treatment of GIOP With Eldecalcitol acronym: ELEGANT overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-12 date: 2026-03 date: 2024-04-25 date: 2024-04-25 name: Chinese SLE Treatment And Research Group class: OTHER name: ... |
<|newrecord|> nctId: NCT06385080 id: 61186372HNC2002 briefTitle: A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Recurrent/Metastatic Head and Neck Cancer acronym: OrigAMI-4 overallStatus: RECRUITING date: 2024-04-22 date: 2026-07-17 date: 2026-07-17 date: 2024-04-25 date: 202... |
<|newrecord|> nctId: NCT06385067 id: JW-PM-DCB-2024 briefTitle: Treatment of Primary Coronary Artery Vascular Lesions With Biolimus Coated Coronary Balloon Dilation Catheter overallStatus: NOT_YET_RECRUITING date: 2024-05-10 date: 2025-12-30 date: 2026-12-30 date: 2024-04-25 date: 2024-04-25 name: JW Medical Systems Lt... |
The study population was patients with primary coronary vascular lesions with a blood vessel diameter of 2.0mm-2.75mm. conditions: Coronary Artery Disease studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 400 type: ESTIMATED name: Biolimus Coated Coronary Artery Balloon Dilation... |
<|newrecord|> nctId: NCT06385054 id: L-027 id: 2023-A02612-43 type: REGISTRY domain: ID-RCB id: PEC23063 type: OTHER domain: Biofortis briefTitle: Effect of Probiotics on Infantile Colic Symptoms acronym: EPIC overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2026-02 date: 2027-02 date: 2024-04-25 date: 2024-04-29 ... |
<|newrecord|> nctId: NCT06385041 id: BE-2-83 briefTitle: Cardiac Rehabilitation and Frailty Physical Training Program in Elderly Patients After Open Heart Surgery overallStatus: RECRUITING date: 2021-05-12 date: 2025-09-01 date: 2025-09-01 date: 2024-04-25 date: 2024-04-25 name: Vitalija Stonkuvienė class: OTHER briefS... |
<|newrecord|> nctId: NCT06385028 id: 20230213_PIANISSIMO briefTitle: Physical Activity Promotion in Osteoarthritis Patients acronym: PIANISSIMO overallStatus: NOT_YET_RECRUITING date: 2024-10-01 date: 2026-03-31 date: 2026-12-31 date: 2024-04-25 date: 2024-04-25 name: Luxembourg Institute of Health class: OTHER_GOV nam... |
A mobile phone application - namely PIANISSIMO - will be developed specifically for this project. It aims to spread knowledge on the benefits of physical activity and collect data on how this knowledge can induce behavior changes toward a more physically active lifestyle. |
The intervention is delivered via the app, which will send daily notifications on physical activity and sedentary behavior, and ask the participants to set their weekly goal (i.e., daily steps). The app will also collect daily steps count and ask the participant to fill in questionnaire on pain once a week. conditions:... |
<|newrecord|> nctId: NCT06385015 id: IRB#23-001257 briefTitle: T-UP: Engaging Vulnerable Students in Diabetes Prevention overallStatus: ACTIVE_NOT_RECRUITING date: 2023-10-04 date: 2024-05 date: 2025-06 date: 2024-04-25 date: 2024-04-26 name: University of California, Los Angeles class: OTHER name: American Diabetes As... |
The specific aims are to: 1) Evaluate the efficacy of adolescents and young adults (AYA)-tailored version of the University of California Diabetes Prevention Program (UC DPP) for mitigating type 2 diabetes risk (i.e., weight change) in a pre/post pilot trial. The investigators hypothesize that the AYA-tailored interven... |
The investigators will randomize participants to the AYA-tailored DPP cohort vs control cohort. Control participants will be offered the opportunity to participate in the AYA-tailored DPP in the following academic year. Participants will be organized into groups within their DPP cohort based on their student status and... |
<|newrecord|> nctId: NCT06385002 id: 2024-0158 briefTitle: Effect of Combined Administration of Sevoflurane and Remimazolam on Emergence overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2025-05-31 date: 2025-05-31 date: 2024-04-25 date: 2024-04-26 name: Pusan National University Yangsan Hospital class: OTHER br... |
<|newrecord|> nctId: NCT06384989 id: MinnesotaHealthSolutions_LL briefTitle: Safety-Enhancing Motor Vehicle Child Safety Seat overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-07-01 date: 2024-08-15 date: 2024-04-25 date: 2024-04-25 name: Minnesota HealthSolutions class: INDUSTRY briefSummary: This study ai... |
<|newrecord|> nctId: NCT06384976 id: KYV101-007 briefTitle: A Study of Anti-CD19 CAR T-Cell Therapy, in Subjects With Refractory Primary and Secondary Progressive Multiple Sclerosis overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-04 date: 2029-01 date: 2024-04-25 date: 2024-04-25 name: Kyverna Therapeutics c... |
<|newrecord|> nctId: NCT06384963 id: Cer22/02 briefTitle: Respiratory Sinus Arrhythmia Pacing Post-CABG Surgery in Patients With HFrEF acronym: RSA-PACE overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-03-01 date: 2025-04-01 date: 2024-04-25 date: 2024-04-25 name: Ceryx Medical Australia class: INDUSTRY na... |
The main questions the trial aims to answer are: |
* Is the new type of pacemaker safe? |
* Does the new type of pacemaker improve how patients' hearts work (also known as cardiac output)? |
Participants will have a range of tests before their operation and during their recovery in hospital while participants have the new type of pacemaker in place, and will be monitored very closely. Participants will also receive a phone call 1 month after their surgery. Researchers will compare the new type of heart pac... |
<|newrecord|> nctId: NCT06384950 id: 2023-11-005A briefTitle: Evaluating the Role of ChatGPT in Educating Patients With Early-stage Hepatocellular Carcinoma overallStatus: RECRUITING date: 2024-03-22 date: 2024-11-29 date: 2025-03-21 date: 2024-04-25 date: 2024-04-25 name: Taipei Veterans General Hospital, Taiwan class... |
The research methodology employs a Randomized Controlled Trial (RCT) design, dividing participants into a control cohort receiving standard patient education routine and an experimental cohort receiving both the AI chatbot and traditional education routine. The comparative analysis of these cohorts will determine the e... |
<|newrecord|> nctId: NCT06384937 id: GCA-PRO-2022-001-01 briefTitle: [Trial of device that is not approved or cleared by the U.S. FDA] overallStatus: WITHHELD date: 2024-04-25 date: 2024-04-25 name: [Redacted] hasResults: False |
<|newrecord|> nctId: NCT06384924 id: SBU-RAMAN-SKINCANCER briefTitle: Raman Spectroscopy and Skin Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-04-30 date: 2025-04-30 date: 2024-04-25 date: 2024-04-25 name: Renee Cattell class: OTHER briefSummary: The goal of this observational study is to find o... |
-Can Raman Spectroscopy help figure out how far a tumor spreads? |
This study will take measurements using laser light from an experimental, handheld probe by lightly touching the skin. conditions: Skin Cancer conditions: Basal Cell Carcinoma conditions: Squamous Cell Carcinoma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 20 type: ESTIMATED n... |
<|newrecord|> nctId: NCT06384911 id: STUDY00004543 briefTitle: InvesT1D: Promoting Adolescent Investment in Diabetes Care overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2027-08 date: 2028-02 date: 2024-04-25 date: 2024-04-25 name: Seattle Children's Hospital class: OTHER name: Harvard Pilgrim Health Care briefSu... |
Adolescent participants will be randomized to usual care or receive financial incentives for meeting diabetes self-management and clinical outcomes goals during the study. Researchers will compare changes in glucose levels and person-reported outcomes between groups. conditions: Type 1 Diabetes studyType: INTERVENTIONA... |
<|newrecord|> nctId: NCT06384898 id: STUDY00002259 id: UH3AT012413 type: OTHER_GRANT domain: National Center for Complementary and Integrative Health briefTitle: Remote Tai Chi for Knee Osteoarthritis acronym: TAICHIKNEE overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2026-12 date: 2027-10 date: 2024-04-25 date: ... |
* Does remote Tai Chi improve the extent to which pain interferes with physical, mental, and social activities (PROMIS-Pain Interference at 3 months, primary outcome), as well as knee pain and function (WOMAC subscales) and analgesic use (secondary outcomes) |
* Does remote tai chi decreases healthcare utilization? |
Researchers will compare remote Tai Chi added to routine care to routine care alone to see if remote tai chi works to treat knee osteoarthritis pain. Participants will participate in remotely delivered web-based tai chi sessions, twice a week for 12 weeks, or will continue to receive routine care. Participants will be ... |
<|newrecord|> nctId: NCT06384885 id: 2024-079 briefTitle: Ultrasound Investigation Into Swimming Induced Pulmonary Edema in Open Water Swimming Athletes acronym: SIPE overallStatus: RECRUITING date: 2024-04-15 date: 2025-06-01 date: 2025-12-01 date: 2024-04-25 date: 2024-04-25 name: Rocky Vista University, LLC class: O... |
<|newrecord|> nctId: NCT06384872 id: 230042_RRI_Interv5 briefTitle: Effect of Shoe Cushioning Position and Properties on Running-related Injury Risk acronym: RRI_Interv5 overallStatus: NOT_YET_RECRUITING date: 2024-10-01 date: 2025-09-30 date: 2025-12-31 date: 2024-04-25 date: 2024-04-26 name: Luxembourg Institute of H... |
1. "Extra soft" cushioning materials can reduce injury risk compared to stiffer materials; |
2. Cushioning under the forepart of the shoe also influences injury risk, independently of the cushioning at the rear part; |
3. Effects of cushioning material and position depend on the runner's body mass; |
4. Perception of cushioning is related to both shoe cushioning and injury risk; |
5. Other weight-bearing locomotion activities (i.e., number of steps per day besides running practice) represents an independent risk factor for running-related injury. |
This study consists in a 6-month intervention trial during which leisure-time runners are required to follow their usual training schedule. Before the beginning of the study, the participants will receive a pair of running shoes. The three running shoe models will be exactly the same, except for their foam properties a... |
Participants will first fill out a baseline questionnaire. During the intervention, data on running practice will be downloaded from sports watches and their respective app via Strava. Information on the use of the study shoes will be collected via a weekly questionnaire. Participants will be asked to fill out a weekly... |
Primary hypothesis: |
- Greater shock absorption properties at the rear part of running shoes are associated with a lower injury risk in recreational runners. |
Secondary hypothesis: |
* Greater shock absorption properties under the forepart of the shoe are also associated with lower injury risk in recreational runners. |
* Runners with low body mass experience a lower injury risk in shoes with greater shock absorption properties. |
* Greater perceived cushioning is related to lower injury risk. conditions: Running-related Injury studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: QUADRUPLE maskingDescription: Participants will be stratified according to their sex. Two pre-est... |
<|newrecord|> nctId: NCT06384859 id: Pending briefTitle: Effectiveness of Extracorporeal Shockwave Therapy Combined With Platelet-rich Plasma in the Treatment of Chronic Insertional Achilles Tendinopathy overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-05-01 date: 2027-05-01 date: 2024-04-25 date: 2024-04-... |
Does ESWT combined with PRP treatment reduce the symptom and improve functional score after treatment? What medical complication do participants have when receive the treatment? |
Researchers will compare ESWT combined with PRP to ESWT treatment alone to see if ESWT combined with PRP works to treat chronic insertional tendinopathy. |
Participants will: |
* Receive ESWT once a week for 4 weeks then receive PRP injection at a week later or ESWT once a week for 4 weeks |
* Visit the clinic at 6 weeks, 3 months, 6 months and 1 year after treatment for checkups and record functional score conditions: Insertional Achilles Tendinopathy studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 94 type: ESTIMATE... |
<|newrecord|> nctId: NCT06384846 id: AI ACS briefTitle: AI Algorithms in Prediction of ACS Based on Leukocyte Properties overallStatus: RECRUITING date: 2024-02-01 date: 2026-07-31 date: 2026-12-31 date: 2024-04-25 date: 2024-04-25 name: RobotDreams GmbH class: INDUSTRY briefSummary: The goal of this observational stud... |
- Can AI algorithms based on white blood cell data predict ACS with accuracy comparable to that of high-sensitivity cardiac troponin (hs-cTn)? Researchers will look at how the AI model's predictions stack up against the standard hs-cTn blood tests to see which is more accurate in diagnosing ACS. |
Participants in this study will have already had blood tests as part of their usual care. Their previously collected health information and blood test results will be used to help train and test the AI algorithms. Participants will not undergo any new procedures for the study itself. conditions: Acute Coronary Syndrome... |
<|newrecord|> nctId: NCT06384833 id: Rama briefTitle: Combination of Vitamin C and N-Acetylcysteine to Improve Functional Outcome After Rotator Cuff Repair overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-09-01 date: 2026-05-01 date: 2024-04-25 date: 2024-04-25 name: Mahidol University class: OTHER briefSu... |
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