Datasets:

habdine

/

Prot2Text-Data

like 3

Q9PRP7

SL114_ECHCA

CA-1 25 kDa subunit chain 1

Echis

DCLPDWFHYEGHCYRVFDEPKKWADAEKFC

Calcium-dependent prothrombin activator. This protein may activate prothrombin via recognition by the regulatory subunit of the calcium ion bound conformation of its gamma-carboxyglutamic acid (GLA) domain, and the subsequent conversion of prothrombin to active thrombin is catalyzed by the catalytic subunit.

Q9PRP7

Q49467

GYRA_MYCGO

Mgo GyrA intein

Mycobacterium

FRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYCLTGDALVRLPFGQSMRIGDVAPGARTNSDNAGELKVLDRHGDPVFADRLFHSGDHQTFRVQTAEGYEVTGTSNHPVLCLVNLAGVPTLLWMLIEEIRPDDYVVLQRAPPVESGPANWRDAMEALLLGAFISEGFMSESRAGFNNVDRDYFNAVVAAYDAVVGGKRYVAQRTIASGSVLNELDIHDVSALKGTRLGVLCGQRSADKSVPEWLWQSPAAVKRVFLQALFEGDGSCSALPRNTIQVSYSTRSRQLAIDVQQMLLEFGVISRRYRHAVGEYKVVITNRAQAELFATQIGFGGAKQSKLTRILGSLPPCAGMDTNHVPGLAAFIRSHCDSEWVDKEWLRKHNIDRLSRWRRDGAEILSRIANPDVRAIATDLTDGRFYYAQVTSVTEAGVQPVYSLRVDSEDHAFLTNGFVSHNTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHN

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Q49467

A6T3N1

TTCA_JANMA

tRNA 2-thiocytidine biosynthesis protein TtcA

Janthinobacterium

MSQALMNTAAATAETDAAMSFKQNEKIVYENNKLHKRLCRQVGQAIGDFNMIEDGDKVMVCLSGGKDSYALLDILMTLRERAPIKFDIVAVNLDQKQPNFPDHILPAYLKQLDIPFHIENQDTYSIVKRLIPEGKTTCSLCSRLRRGILYRVADELGANKIALGHHRDDIMETFFLNMFFGAKIKGMPPKLQSDDGKHIVIRPLAYVKEADTERYAEVKNFPIIPCDLCGSQENLQRKQIKGMLREWEKKFPGRVDNIFSSLSTVVPSHLMDKELFGFADLKATGEAMANGDIAFDEEPCSTGSTSIPGIIPLRADD

Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.

A6T3N1

Q8Y206

MIAB_RALSO

tRNA-i(6)A37 methylthiotransferase

Ralstonia

MKKVFIKTFGCQMNEYDSDKMADVLNAAEGLVPTDTPEDADVILFNTCSVREKAQEKVFSDLGRVKALKARNPDLVVGVGGCVASQEGASIVARAPYVDVVFGPQTLHRLPELIDARRRTGRPQVDVSFPEIEKFDHLPPARVEGPSAFVSIMEGCSKYCSYCVVPYTRGEEVSRPFEDVLAEVAGLAEQGVREVTLLGQNVNAYIGKMGGTSERADFALLLEYVAEIPGIERIRYTTSHPKEFTARLIEAYATNRKLVDHLHLPVQHGSDRILMAMKRGYTVLEYKSIIRKLRAIRPDISIATDFIVGFPGETDADFAKTMDLVHEIGYDNSFSFIYSPRPGTPAANLHDDTPHAVKLERLKHLQATIDANMARISEGMVGSVQRILVEGPSRKDPSELHGRTENNRVVNFALPDLPQARRDQLVGQMLDVRIVHAYPHSLRGDVVEQRPDGVTQH

Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.

Q8Y206

Q1H4Q1

EFTU1_METFK

Elongation factor Tu 1

Methylobacillus

MAKGKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLTKKFGGEAKDYSQIDNAPEEKARGITINTSHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIIVFLNKADMVDDAELLELVEMEVRELLSKYDFPGDDTPIIKGSAKLALEGDQSDIGEPAIFRLAEALDTYIPTPERAVDGTFLMPVEDVFSISGRGTVVTGRVERGIVKVGDEIEIVGLKPTIKTTCTGVEMFRKLLDQGQAGDNVGVLLRGTKREEVERGQVLAKVGSIKPHTKFTAEIYVLGKDEGGRHTPFFNGYRPQFYFRTTDVTGAVELPAGTEMVMPGDNVSISVSLIAPIAMEEGLRFAIREGGRTVGAGVVAKIIE

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

Q1H4Q1

B2IG63

PTH_BEII9

Peptidyl-tRNA hydrolase

Beijerinckia

MLLFVGLGNPGKAYSANRHNIGFMAIDAIAREYGAPAFRARFQGLTSEITLSGEKIVLLKPETYMNESGRSVSDAVHFYKIDASRVIVFHDELDLAPGKVRVKKGGGNAGHNGLKSITQHITNDYRRVRIGIGHPGIKDMVRHYVLGDFSKTESAWVETLCLSIAVNAPLLAKGEDENFQNKIFHAMETAGLAKDGLF

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

B2IG63

Q99M64

P4K2A_RAT

Phosphatidylinositol 4-kinase type II-alpha

Rattus

MDETSPLVSPERAQPPEYTFPSVSGAHFPQVPGGAVRVAAAGSGPSPPCSPGHDRERQPLLDRARGAAAQGQTHTVAAQAQALAAQAAVAVHAVQTHRERNDFPEDPEFEVVVRQAEIAIECSIYPERIYQGSSGSYFVKDSQGRIIAVFKPKNEEPYGNLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIKYDYPMDNPNCRDTDWVMVREPVIKVAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDLEEDLYELFKKDPGFDRGQFHKQIAVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSHQRSSSESYTQSFQSRKPFFSWW

Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).

Q99M64

Q2S2A5

HEM1_SALRD

Glutamyl-tRNA reductase

Salinibacter

MRFYAVGLNHECTSLEQTETFALSAEEQEALYANLSLSADAEVVVLSTCNRTEAYLYGTEADLRQVKALIGQGGGTRWPEETAFQERDEAAVRHLLQVTSGLRSVVLGERQIFAQVKAAYERAVDAGGIHSVMHRLFHTAFRAAKRVSSETGLGRGAASVSTAAVEMARQDLSEAGGEGLRNTEIVLVGAGKMGRLALEALADESLASLTVVNRSPDRAREVASPFGGDTEPWADRHRAVATADLALVATGASDPVLHAPALPAPDEATLVVDVAMPRNVDPAVDERPGYRLYDLDDLEAWTAEVRERRADAVPEAESICEELLEDFVTWVFHQQALQPAIQAIRSTFDTIREQEVDRHAHRTGMDREEVDRLTESIMQKLLAVPIVRLKNVDPESIDFVQGIELLHALFAPSDESDAGRSLAEAPDADTPDLGEAPSRCPYMTHDPGGDGTETEEVQKALRLSAAHQAASHSEEVRGG

Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).

Q2S2A5

Q4L5D8

COAD_STAHJ

Pantetheine-phosphate adenylyltransferase

Staphylococcus

MAKTKAVIPGSFDPITYGHIDIIERSAGRFDELHICVLKNSNKTGTFNIDERMALIEESVKHLSNVEVHNYNGLLVDFCDKIGAQTIIRGLRAVSDFEYELRLTSMNKKLNSNVETMYMMTSTNYSFISSSVVKEVAQYKADISDFVPPNVEKALKEKFKK

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

Q4L5D8

Q03K76

HISZ_STRTD

ATP phosphoribosyltransferase regulatory subunit

Streptococcus

MKKTTLALGMHDKLFKRARTMYQIEHCICDLLMTKGFLRIETPTLEHFEVFSDVVDNGNYNFFDKNGDLISLRPDITSQIGRVIASTQVHTPIKFSYSGKVFNYNEEMRGLSNEHTQAGVEIIGFPVHQALEEAVISAKEALDVAGVRNYKFEFSHAQLLQLIFEELNLPAVKEAELATYIRDKSITGLKEFTKENPSQYDKVLEQLPSLFGETTAVLTEARQLTDNESFLTALDSLEVLTSRLADNLPETTLDLAQLPAVPYYTGIMFKVFGDKVPDAFVSGGRYDKLFERFGATELTAVGWAIDIDSVYQAVHDDVEFGGDMDD

Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.

Q03K76

Q4JAC0

CDPAS_SULAC

CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase

Sulfolobus

MIGLLLGLIYYIPALVANGSAPFIKSGTPIDFKRKLNDGRRVLGDGKTFEGLLLSLTFGTTVGAIISRFLGIEWIIIGFVESLGAMLGDMLGAFIKRRIGLERGARAPILDQLDFILGATVVLISFNVNLNIYQVVFVCVLVIALHMFTNYVAYRLKIKSVPW

Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

Q4JAC0

Q9A5A7

MURB_CAUVC

UDP-N-acetylmuramate dehydrogenase

Caulobacter

MTWKTQLPTARGKLLIDEALAPFTWFRVGGPADVVFLPADEQDLSDFLKGLDPSVPVMAIGVGSNLLVRDGGVDGVVIRLGKGFNGVEALGDNRIKAGSAVPDAILARKAAEAGIAGLEFYVGVPGTIGGAVIMNAGCYGAETVNVVKSVRVMNRAGVVRELSVEDLHYTYRHSALQDGEPVIVLDAIFEGTPDEPEAIKARMAEITARRETTQPIREKTGGSTFKNPPGHSSWKLVDEAGWRGKPYGGAMFSPLHSNFLINTGEATAADLEGLGEAVRADVLAKTGVQLDWEIKRIGRAG

Cell wall formation.

Q9A5A7

Q4L6J7

XERD_STAHJ

Tyrosine recombinase XerD

Staphylococcus

METIIEEYLKFIQIEKGLSENTIGAYRRDLKKYQLYMQEQKIAHIDFIDRQTIQECLGSLIDQGASAKSIARFISTIRSFHQFALREKYAAKDPTVLIETPKYEKKLPDVLDVEEVIQLLETPDLTKNNGYRDRTILELLYATGMRVTELIQIEIDDVNLIMGFVKVFGKGNKERIIPLGDTVIEYLDTYINNVRSQLLKKTVTNVLFLNLHGRPLTRQGIWKLIKQYGLRANINKTLTPHTLRHSFATHLLENGADLRAVQEMLGHSDISTTQLYTHVSKTQIRQMYNQFHPRA

Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

Q4L6J7

Q8TCV5

WFDC5_HUMAN

p53-responsive gene 5 protein

Homo

MRTQSLLLLGALLAVGSQLPAVFGRKKGEKSGGCPPDDGPCLLSVPDQCVEDSQCPLTRKCCYRACFRQCVPRVSVKLGSCPEDQLRCLSPMNHLCHKDSDCSGKKRCCHSACGRDCRDPARGTAPGCPGQANSDLGSVALHLSWGPTERVHDGRPGALPAGQHYLYQRWFQPSDNHWPADTSLQPIHPWFLLLGVKVHSLSSEEGLCITPVLCTTAIRASHPS

Putative acid-stable proteinase inhibitor.

Q8TCV5

B4SGD1

RISB_PELPB

6,7-dimethyl-8-ribityllumazine synthase

Pelodictyon

MQVKQIEGVLNAKDIRFALVVGRFNDFIGQKLVEGAIDCICRHGGSEECIAMYRCPGAFELPMVAKKVALSGKYDAIITLGVIIRGSTPHFDVLAAEATKGIAQVALDTMVPIAFGVLTTENIEQAIERAGTKAGNKGFDAAMTAIEMVNLYRQI

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

B4SGD1

P97527

CNTN5_RAT

Neural recognition molecule NB-2

Rattus

MASSWRLILFLSFTSCLSEYSEALSGLSTSYAALLRIKKSSTSSAFGSKSRPRYSSPSLGTLSVSPPSWRGAAQQYHSPVNLYHSPDAFRQDESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPSPTYRWLRNGTEIDLESDYRYSMIDGTFIINNPSESRDSGLYQCLATNTFGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNAVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPTTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKSRLRKSQAVLEIPNLQLDDAGIYECTAENSRGKNSFRGQLQIYTYPHWVQKLNDTQLDSGSPLQWECKATGKPRPTYRWLKNGAPLLPQSRVDTANGVLAIHSVNQSDAGMYQCLAENKYGAIYASAELKILASPPSFELNQVKKSIIVTKDREVLIECKPQGSPKPAISWRKGDKAVRGNKRIAILPDGSLRILNASKADEGKYICQGVNIFGSAEIIASVSVKEPTRIELTPKRTELTVGESIVLNCKAMHDSSLDVTFYWTLKGQPIDFEKEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGVVIVEEITESTATLSWSPATDNHSPISSYNLQARSPFSLGWQTVKTVPEVITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSIPSRMIRTNEAVPKTAPSNVSGGSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSDASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPTAAPTDVTATSVSVSEIFVVWKHVKESLGRPQGFEIGYWKDTEPEDSAETVRTRGNESFVMLTGLEGDTLYHLTVRAYNGAGYGPPSREVSATTKRHPPSEPPGNLRWEQQGSQVSLGWEPVRPLANESEVMGYKVFYRQEGHSKGQVIETQKPQAVVPLPEAGVYIIEVRAYSEGGDGTASSQIRVPSYAGGKITSAQSTLHSLSKWSSVTLLLALMLPSSSW

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system.

P97527

B9DHG0

PYG7_ARATH

Protein PALE YELLOW GREEN 7

Arabidopsis

MFESNMVLQTLSSSSPPIHRLYLHHSQILPSSGSPSKISLQIHGRTLAIRSFHDYVFAEISARGLPALNKASLKKLPIKGSTFLLGQSLLMVSAHPQLAAAAEIIKPEPIYEVGELFELSIQLSYLLLLLGLLGVGTFYVIRQVLVRRELDLSAKELQEQVRSGDASATELFELGAVMLRRKFYPAANKFLQQAIQKWDGDDQDLAQVYNALGVSYVREDKLDKGIAQFEMAVKLQPGYVTAWNNLGDAYEKKKELPLALNAFEEVLLFDPNNKVARPRRDALKDRVKLYKGVVAVKSKKR

Nuclear genome-encoded factor required for the accumulation of photosystem I (PSI). Functions as PSI biogenesis factor . Cooperates with PSA3 to promote the stable assembly of PSI in the thylakoid membrane. May target primarily the PsaC subunit .

B9DHG0

B0TZI5

GLGB_FRAP2

Glycogen branching enzyme

Francisella

MKNVNSKQNNHSTIGEQDIHFFHEGKHIYAYEFMGAHKASEDGIDGIRFTTWAPNAKSICVIGDFNHWQVEDKNHMKRITDAGLWSVFIADVKDGDKYKFVVTNKDTNHYVYKSDPYAFFSELRPNTASVISTQTTYKWHDEKWLKKRATADYYNSPMNTYELHLASWKTKDDRFMTYEEIAEVLPKYVKDMGYTHVEFMPLHEHPLDASWGYQPTGFYSINSRHGDLVGLKHLVDKLHTHDIGVILDWVPGHFCKDQHGLINFDGSACYEYQEPTKAINKGWGTHNFDLGRNEVKCFLISNAMYWINEFHIDGLRVDAVSNILYLNYDREDGQWVPNIHGGHENLEGIAFLRELNGVLKHTCKGVITIAEESSSWPNISTPVEQGGLGFDFKWNMGWMNDTLRYISLDPVYRKYHHNLITFSMVYHYSEKFILSISHDEVVHGKKSLINKMWGDLWNKYAGLRLYMSFMIGHPGKKLIFMGSEFGQFIEWREYEQLQWQVVDEYHTHRETLNFFKKLNEFYKAETALWECDYDHKGFQWIDANNSEQSILSFVRSNKDGKEKLIFVCNFTPVTYYDYHIGVPDAGSYIEAFNSDDLEFGGSGQLIADEIFSTPESSHGFDQRITIKVPPMATLVLKLKK

Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.

B0TZI5

Q6P9X9

PARM1_RAT

Prostatic androgen-repressed message 1 protein

Rattus

MVCKALITLCIFAAGLRVQGSPTPTLLPVSLTTKSTAPMATWTTSAQHTAMATTPVASATHNASVLRTTAASLTSQLPTHPREEAVTSPPLKREVNSTDSSPTGFSSNSSGIHLAPTPEEHSLGSPETSVPATGSQSPTLLFSQGPTSASTSPATSPSEPLSASVTSNHSSTVNNIQPTGAPMAPASPTEEHSSSHTPTSHVTEPVPKEKSPQDTEPGKVICESETTTPFLIMQEVENALSSGSIAAITVTVIAVVLLVFGAAAYLKIRHSSYGRLLDDHDYGSWGNYNNPLYDDS

May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis.

Q6P9X9

B0B960

MURB_CHLT2

UDP-N-acetylmuramate dehydrogenase

Chlamydia

MTDSFPFSVQESVPLSRFSTFRIGGPARYFKELTSLSEALTVFSYLHTHPLPYIIIGKGSNCLFDDQGFDGLVLYNNIQGQEFLSDTQIKVLSGSSFALLGKRLSSQGFSGLEFAVGIPGTVGGAVFMNAGTTLANTASSLINVEIIDHSGILLSIPREKLLFSYRTSPFQKKPAFIASATFQLTKDPQAAKRAKALIEERILKQPYEYPSAGCIFRNPEGLSAGALIDRAGLKGLKIGGGQISEKHGNFIINTGNACTADILELIEIIQKTLKKQGISLHKEVRIIPFRL

Cell wall formation.

B0B960

Q8T295

PRP8_DICDI

Splicing factor Prp8

Dictyostelium

MDDTNSNINQSNESQHLEEKAKKWIQLNNKKYSEKRKFGAVEIRKEDMPPEHLRKIIKDHGDMSNRRFRDDKRVYLGALKYMPHAILKLLENIPMPWEQVKYVKVLYHLSGAITFVNEIPFVIEPIYIAQWATMWVTMRREKRDRTHFRRMKFPLFDDEEPPLDYSDNILDNEVEDPIQMELDENDDSEVIDWLYDSKPLVNTKFVNGSSYRKWRLNLPIMSTLFRLASPLLSDLTDSNYFYLFDDNSFFTSKALNMAIPGGPKFEPLFRDVDDDDEDWNEFNDINKVIIRNKIRTEYKIAFPYLYNSRPRKVKTPTYHTPNNCYIKNDSPDLPGFYFGAALNPIPSYKTSGNKNEQSEYGTEDDEFQLPEEIETILSKTEIEHDNLANGIQLYWAPRPFSLRSGTTRRAEDIPLVKSWYKEHCPSEHPVKVRVSYQKLLKCHVLNKLHHRKPKAQTKRNLFKSLKATKFFQSTEIDWVEAGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFYLKPIKTLTTKERKKSRFGNAFHLCREILRLTKLVVDVHVKFRLGDADAFQLADAIQYLFSHLGLLTGMYKYKYRLMRQIRMCKDLKHLIYYRFNTGAVGKGPGCGFWAPMWRVWLFFLRGIVPLLERWLGNLLARQFEGRQTKGMAKTVTKQRVESHFDYELRAAVMHDILDMMPEGIKANKSRIILQHLSEAWRCWKSNIPWKVPGLPIPIENMILRYVKSKADWWTNIAHYNRERIKRGATIDKTASKKNLGRLTRLWLKAEQERQHNYLKDGPYVSAEEAVAIYTTTVHWLEKRRFSAIPFPQTSYKHDIKILTLALERLKEAYSVKSRLNQSQREELSLVEQAYDNPHDALARIKRHLLTQRTFKEVGIEFMDMYTHLVPIYDVDPFEKITDAYLDQYLWYEADKRQLFPNWVKPSDNEPPPVLIHKWCQGINNLDQVWETSQGECVVLLETQFSKVYEKMDLTLMNRLLRLIVDQNIADYMSGKNNVVINYKDMNHTNSYGLIRGLQFASFIFQYYGLVLDLLVLGLERASALAGPPNLPNSFLTFPSVQTETAHPIRLYSRYVDRIHVLYKFTADEARKLIQKYMSEHPDPNNENVVGYNNKKCWPRDCRMRLMKHDVNLGRAVFWQIKNRLPRSLTTIDWEDSFVSVYSKDNPNLLMNMAGFDIRILPKCRTPLDQLAPKDAVWSLQNVNTKERTAQAFLRVDTESQERFENRIRMILMASGSTTFTKIVNKWNTALIGLMTYYREAVVTTREMLDILVRCENKIQTRVKIGLNSKMPNRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLKYSKQTDTGITHFTSGMSHDEDQLIPNLYRYIQPWEQEIKDSQRVWAEYAIKYEEAKSQNKNLTLEDLEDSWDRGIPRINTLFQKSRHTLAYDKGWRVRTDWKQYQVLKNNPFWWTNQRHDGKLWNLNNYRTDIIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKYKKLTHAQRSGLNQIPNRRFTLWWSPTINRKNVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESLVMDLCQVFDQELDNLEISVVNKEAIHPRKSYKMNSSCADILLRATHKWQVSRPSLLNDNRDTYDNTTTQYWLDVQLKWGDFDSHDIERYSRAKFLDYTTDSMSLYPSPTGCLIGLDLAYNIYSSFGNWFLGVKPLVQKAMAKILKSNPALYVLRERIRKGLQLYSSEPTEPYLSSQNFGELFSNKIMWFVDDSNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTDVWLGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIATRKGMMDPLEVHLLDFPNIVIQGSELQLPFQACLKVEKFGDLILKATEPKMVLFNIYDDWLSTIHSYTAFLRLILILRALHVNLERTKIILKPNKNVITQPHHIWPTLTEQEWLTVEGSLKDLILADFGKRNNVNVASLTQSEIRDIILGMEISAPSQQREDQIAEIEKQKTEASHLTAVTVRSTNIHGEEIITTATSPHEQKVFSSKTDWRVRAISATNLHLRTNQIYVNSDNAKETGGFTYVFPKNILKKFITIADLRTQIMGYCYGISPPDNPSVKEIRCIVMPPQWGTPVHVTVPNQLPEHEYLKDLEPLGWIHTQPTELPQLSPQDVITHSKIMSDNKSWDGEKTVIISVSVAWPCTLTAYHLTPSGFEWGKNNKDSLNYQGYQPQFYEKVQMLLSDRFLGFYMVPDRGSWNYNFMGVKHSTNMTYGLKLDYPKNFYDESHRPAHFQNWTQMAPSANDDEENQPENENLFE

Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.

Q8T295

P36630

CG22_SCHPO

G2/mitotic-specific cyclin cig2

Schizosaccharomyces

MALYSISKPVGSKINKHSYQDENTLVGKQALSKGTEKTKLSTNFEINLPRRTVLSDVSNVGKNNADEKDTKKAKRSFDESNLSTNEEADKPVESKFVKKLKVYSKNADPSVETLQKDRVSNVDDHLSSNPLMAEEYAPEIFEYIRKLDLKCLPNPKYMDQQKELTWKMREILNEWLVEIHSNFCLMPETLYLAVNIIDRFLSRRSCSLSKFQLTGITALLIASKYEEVMCPSIQNFVYMTDGAFTVEDVCVAERYMLNVLNFDLSYPSPLNFLRKISQAEGYDAQTRTLGKYLTEIYLFDHDLLRYPMSKIAAAAMYLSRRLLRRGPWTPKLVESSGGYEEHELKEIAYIMLHYHNKPLEHKAFFQKYSSKRFLKASIFVHQLVRQRYSVNRTDDDDLQSEPSSSLTNDGH

Essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. Interaction with res2 promotes the phosphorylation of res1 and inhibits MBF-dependent gene transcription. Forms an autoregulating feedback-inhibition loop with MBF which is important for normal regulation of the cell cycle. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Negatively regulates conjugation via interacting with cell cycle 'start' genes. Degraded by skp1, pop1 and pop2 in the G2 and M phases of the cell cycle.

P36630

Q3B6L9

IF3_CHLL3

Translation initiation factor IF-3

Pelodictyon

MKKQKATSQKPKITYRVNEQIRVPEVRIIFPDGTQQVMKTIDARRMAEDRNTDLIEVQPNAEPPVCKFDNLGKLLYKMAQRDKDLKKKQKTTTLKELRFHPNTDKHDFDFKTAHLEEFLRKGNRVRATIVFLGRSIIYKDKGLELADRLTERLSVVGNREGEPKFEGKKLFVYFEPDKKKIDAYERIRSKTGTPLAPLEESADAED

IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.

Q3B6L9

A8FZE2

MIAA2_SHESH

Isopentenyl-diphosphate:tRNA isopentenyltransferase 2

Shewanella

MKNFNLILVIGATASGKTRLGVELARQLEGEIISADSRQVYKGLDIGSGKDLAEYGEVPHHLIDIVEPGHEYNAFQFQQDFFEAFTYIESRNKQPILVGGTGLYVDAVVSGYEFVQLDKDLALRAELDLQPLEQVQKLLLELDAAQYEKTDLTVRPRLYRAIEIAKNKQTNPKPAKALPEIRPLYFGIQWDRKVLRKRIKTRLKERFEQGMVEEVQGLLDNGVSHEQLEYYGLEYRFVSQYIAGQIGYEEMFDRLNTAICQYAKRQETWFRRIEKHGGKIHWLQGSGDIYQQACEVLADLG

Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).

A8FZE2

Q6KI50

RL22_MYCMO

50S ribosomal protein L22

Mesomycoplasma

MESRATVKVQRISARKARLVADLIRYKSANDALSILYNTNKKASALFIKLLNSAVANAINNHGMNNEKLVVEKVLVNEGPTLKRFQPRSQGRAYSIFKRTSHLEIVLKEK

The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.

Q6KI50

A6LMK5

PANB_THEM4

Ketopantoate hydroxymethyltransferase

Thermosipho

MTIQKFLAMKGKEKIVMVTAYDTPTAKIAEEAGVDIILIGDSIGNNVLGYDSTIPVTMEEIIIHLKAVRRGAPNSFIVADMPFLSYGHSIEEAVKNAGILIKNGANAVKIEGGKFHCNLIEKCINIGIPVMGHLGFTPQSINIFGGYKVQGKKEDSKKTILESAIALEQCGVFSIVLEMVTEELAKEITEKISIPTIGIGAGRYCDGQVLVFHDIVGLNPNFKPKFSKQYANTYSIMLNALKEFKKDVKEKNFPKERHTFKGGK

Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

A6LMK5

A3MRW0

RS3_BURM7

30S ribosomal protein S3

pseudomallei group

MGQKIHPTGFRLAVSRNWASRWYANNNNFAAMLQEDIGVREYLKKKLKNASVGRVVIERPAKNARITIFSSRPGVVIGKKGEDIELLKTELQRRMGVPVHVNIEEIRKPETDAQLIADSITQQLERRIMFRRAMKRAMQNAMRLGAQGIKIMSAGRLNGIEIARTEWYREGRVPLHTLRADIDYATSEAKTTYGIIGVKVWVYKGDTLGRNDAPVVEEVTEDKRPRRNARPGDRRPRRDGEGGAPGARRGGPRRGAGKPEDGKTGE

Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.

A3MRW0

Q06FK6

PSAJ_PELHO

PSI-J

Pelargonium

MRDLKTYLSAAPVLSTIWFGALAGLLIEINRFFPDALTFPFFSF

May help in the organization of the PsaE and PsaF subunits.

Q06FK6

P27683

RK24_SPIOL

Chloroplastic large ribosomal subunit protein uL24c

Spinacia

MAAMAALQSSFTSLSLSSNSFLGQRLFPSPTTLQVKTEGHSPCLIVMRIKRWERKDCKPNSLPKLHKMHVKVGDTVKVISGGEKGKIGEISKIHKHNSTVIIKDLNLKTKHVKSKEEGEQGQIIKIEAAIHSSNVMLYSKEQEVASRVGHKILEDGRKVRYLIKTGEIVDTPDRWKEIQNKKESETAVAVAA

Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus.

P27683

P0AE58

CAIF_ECOLI

Transcriptional activatory protein CaiF

Escherichia

MCEGYVEKPLYLLIAEWMMAENRWVIAREISIHFDIEHSKAVNTLTYILSEVTEISCEVKMIPNKLEGRGCQCQRLVKVVDIDEQIYARLRNNSREKLVGVRKTPRIPAVPLTELNREQKWQMMLSKSMRR

Potential transcriptional activator of carnitine metabolism.

P0AE58

Q9H8T0

AKTIP_HUMAN

Fused toes protein homolog

Homo

MNPFWSMSTSSVRKRSEGEEKTLTGDVKTSPPRTAPKKQLPSIPKNALPITKPTSPAPAAQSTNGTHASYGPFYLEYSLLAEFTLVVKQKLPGVYVQPSYRSALMWFGVIFIRHGLYQDGVFKFTVYIPDNYPDGDCPRLVFDIPVFHPLVDPTSGELDVKRAFAKWRRNHNHIWQVLMYARRVFYKIDTASPLNPEAAVLYEKDIQLFKSKVVDSVKVCTARLFDQPKIEDPYAISFSPWNPSVHDEAREKMLTQKKPEEQHNKSVHVAGLSWVKPGSVQPFSKEEKTVAT

Component of the FTS/Hook/FHIP complex (FHF complex) . The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell .

Q9H8T0

A5USH9

RL14_ROSS1

50S ribosomal protein L14

Roseiflexus

MVQQETRLRVADNTGAKEILCIRVLGGSRVRYGRVGDVIVASVKEATPGGAVKKGEVVRAVIVRTAKEYGRPDGSHIRFDDNAAVIIGKDNNPRGTRIFGPVARELRERAFMKIISLAPEVL

Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.

A5USH9

Q31I42

DDL_HYDCU

D-alanylalanine synthetase

Hydrogenovibrio

MTQSSNQTKDRVQRLGKVAVLMGGVAAERDVSLRSGAEVLKALKSEGVDAVGCDVTSVAQLVEIAQKYDRAFIALHGRWGEDGGVQAVLDSLALPYTGSGMTASALAMDKLRTKWLWKGVGLPTPAFIVVSPSRPLDVETFDLTFPVIVKPSHEGSSIGMRKVDTLDALQEAVDFAQQYDSEILIEQWITGREFTCAVLDGEALPMIQLKTDHDFYDFDAKYQSNTTEYLCPCGLEIAEEKRIQALVLQAFDAVGARHWGRVDLMLDDQNQPWLIEINTVPGMTDHSLVPMAAKAVDLSFSKLVLKLISLTLP

Cell wall formation.

Q31I42

A6Q908

AROB_SULNB

3-dehydroquinate synthase

unclassified Sulfurovum

MIVPIELAHTKNITYDITIDALPQLTFDTKVAVVTNPTVAGYHLQTLLAHIKAPQLEVITVPDGEEYKTLETVETILNELFEHKFDRKSLLIAFGGGVIGDMTGFTASLYQRGIDFIQIPTTLLSQVDASVGGKTGVNNRYGKNLIGAFYQPKAVYIDPAFLKTLPSREFSAGVAEIIKMAVMFDKDYFEFLVTADLSDEEVLKETIRRSVELKAWVVNQDEKEAGIRAVLNYGHTFGHVVENETGYTTYLHGEAVAIGMVMANALAVELGLLGETEADRIKALLEKASLPTHYTIKDVDDFYEHFFLDKKSANNSIKFILPEGIGGHKIVSDIDESVVKNVLKKFEEEV

Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).

A6Q908

Q7GBC8

URM1_ORYSI

Ubiquitin-related modifier 1 homolog

Oryza sativa

MHLTLEFGGGLELLLEKSTKVHKVDLQPNDGDGKVVMKGLLAWVKSNLIKERPEMFLKGDSVRPGVLVLINDCDWELCGGLDAELEEKDVVVFISTLHGG

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Q7GBC8

Q1QP86

GLMM_NITHX

Phosphoglucosamine mutase

Nitrobacter

MSRKYFGTDGIRGRANGLITPELAMKVGQAAGLVFQRGEYRHRVVIGKDTRLSGYMIEYALVAGFTSVGMDVLLLGPMPTPAVAMLTKSMRADLGVMISASHNLFEDNGIKMFGPRGFKLSDAVEKQIEQLLDENLDKKLAQSTGLGRARRIDGVHDRYIEFAKRTLPRELSLDGLRVVVDCANGAAYRVVPEALWELGADVVPISVEPDGFNINKECGSTAPEALCRKVREMRADIGIALDGDADRVIIVDERGHVVDGDQLLAVIAESWKEDGRLTKPGIVATVMSNLGLERFLEGQELSLVRTPVGDRYVLEQMLKQGYNLGGEQSGHIILSDYATTGDGFVSALQVLAVVQKLGRPVSEVCHKFEPLPQILKNYRYRSGKPLDRAEVKSAITAGEKRLNGHGRLLVRSSGTEPVIRVMGEGDDRILVEDVVDTIVSALGGPAAA

Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

Q1QP86

B7MRB3

RPOB_ECO81

Transcriptase subunit beta

Escherichia

MVYSYTEKKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQDPEGQYGLEAAFRSVFPIQSYSGNSELQYVSYRLGEPVFDVQECQIRGVTYSAPLRVKLRLVIYEREAPEGTVKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLFVRIDRRRKLPATIILRALNYTTEQILDLFFEKVIFEIRDNKLQMELVPERLRGETASFDIEANGKVYVEKGRRITARHIRQLEKDDVKLIEVSVEYIAGKVVAKDYIDESTGELICAANMELSLDLLAKLSQSGHKRIETLFTNDLDHGPYISETLRVDPTNDRLSALVEIYRMMRPGEPPTREAAESLFENLFFSEDRYDLSAVGRMKFNRSLLREEIEGSGILSKDDIIDVMKKLIDIRNGKGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDTLMPQDMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHKRRISALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLSVYAQTNEYGFLETPYRKVTDGVVTDEIHYLSAIEEGNYVIAQANSNLDEEGHFVEDLVTCRSKGESSLFSRDQVDYMDVSTQQVVSVGASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMERAVAVDSGVTAVAKRGGVVQYVDASRIVIKVNEDEMYPGEAGIDIYNLTKYTRSNQNTCINQMPCVSLGEPVERGDVLADGPSTDLGELALGQNMRVAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELACVSRDTKLGPEEITADIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNGVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDLSEELQILEAGLFSRIRAVLVAGGVEAEKLDKLPRDRWLELGLTDEEKQNQLEQLAEQYDELKHEFEKKLEAKRRKITQGDDLAPGVLKIVKVYLAVKRRIQPGDKMAGRHGNKGVISKINPIEDMPYDENGTPVDIVLNPLGVPSRMNIGQILETHLGMAAKGIGDKINAMLKQQQEVAKLREFIQRAYDLGADVRQKVDLSTFSDEEVMRLAENLRKGMPIATPVFDGAKEAEIKELLKLGDLPTSGQIRLYDGRTGEQFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGNHQMEPGMPESFNVLLKEIRSLGINIELEDE

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

B7MRB3

A5EG97

CCME_BRASB

Heme chaperone CcmE

unclassified Bradyrhizobium

MTRKQRRLTIIGGALFVLAVAAGLVLNALRDSIVFFSTPTMVAEKHIGPGKRFRLGGLVQPGSLKRGDDLAVTFEVADGGAKLPVAYKGILPDLFREGQGVVAEGALDAAGVFKADTVLAKHDETYMPKEVADTLKKQGHWKDDYGKPQAAKPGPVSMREGEKTAAGATQ

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

A5EG97

Q72SX8

ATPE_LEPIC

F-ATPase epsilon subunit

Leptospira

MSANKLKVSVISPEKILYKGEVDSLIVPGSEGFFGILPNHAPLVATLGIGILEIRKGEKLKVLSVEGGFVEIKDNSISILTDHGALKEDIDLEVEKKNLAEAEKLPPSDSKNLFLQKTKTRILVASR

Produces ATP from ADP in the presence of a proton gradient across the membrane.

Q72SX8

Q8ST83

PHO_DROME

Transcription factor YY1 homolog

Sophophora

MAYERFGIILQSEQYDEDIGNTKVNQKMNEGNHYDLHRKNAFDRIIHSESKKGDNVINYNIHENDKIKAADNIFSSKLKMNPNMSYEMNINCFKNIGYGENQETSKVLTNSLSNNDINTEESGVVDKNSPFLTLGTTILNSNGKSRRWEQKLVHIKTMEGEFSVTMWASGISDDEYSGSDQIVGASDLLKGKEEFGIDGFTSQQNKEYQKMESKFTNAQTLEMPHPISSVQIMDHLIKERGNLSQENNISERILSKTTLSFEEPILLPDSSSIELVNETAAMTINNHRTLSNHTGNTGDLHALPSSVPFRIGLHEGQVNDCLSTISQSTHQDNTDSTGCGEMNLSEVTVSYTNDKKIACPHKGCNKHFRDSSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPFVCPFDACNKKFAQSTNLKSHILTHAKAKRNTSISGKSGCSNAESNSQSEDTSANYVKVELQDSVTENHVPFVVYAD

Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Q8ST83

Q7U9F0

AROC_PARMW

5-enolpyruvylshikimate-3-phosphate phospholyase

Parasynechococcus marenigrum

MGSSFGDLFRISTFGESHGGGVGVIVEGCPPRLDLDVDAIQAELDRRRPGQSHITTPRKEADQVEVLSGLLDGQTTLGTPIAMLVRNKDQRPGDYKDMAVAFRPSHADATYQVKYGVQARSGGGRASARETIGRVAAGAIAKQLLAKAAGTEVLAWVKRIHTIEANVDPQAVTLDAIESNIVRCPDASTAAQMVERIEAIGRDGDSCGGVIECVVRNPAPGLGMPVFDKLEADLAKAVMSLPATKGFEIGSGFSGTLLKGSEHNDAFVPTDDGRLQTATNNSGGIQGGISNGEPIVIRVAFKPTATIRKEQQTIDSDGKATTLAGKGRHDPCVLPRAVPMVEAMVALVLADHLLRQQGQCSLW

Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.

Q7U9F0

A4XA62

SYE_SALTO

Glutamyl-tRNA synthetase

Salinispora

MRFAPSPTGMFHVGGARSALQNWIFAKQQGGVFVLRVEDTDAARNKPEWTEGILAALEWIGIARGSYEGPYFQSSYATEHRAAASRLHEGGRAYYCDCTREVVQARTGSPHTGYDGFCRDRNLGPGAGRALRFRTPDEGATVVVDLIRGEPTFDNRLIEDFVIARSDGSPVFLLANVVDDMTMGITHVIRAEEHLPNTPKQQLLWDALGVKPPVWAHVPVVVNEKRQKLSKRRDKVALEAYRDEGYLADAMCNYLMLLGWAPSGDREIVPWPVIEEEFRLEEVNPSSAFFDEKKLRAFNGEYIRALPIAEFIAGCQPWLTGTATIAPPPWQPDEFDAEAFAAVAPLAQTRIAVLSEIVPNVDFLFLDSPLIDEGAWAKAMKEGAGDLLDAVIAAFTALPSWDADSTKSTLEAVGAEHGLKLGKAQAPVRVAVTGRRVGLPLFESLEVLGRERTLTRLRAARLRLP

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

A4XA62

P52195

CMA1_PAPHA

Mast cell chymase

Papio

MLLLPLPLLLLFLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKSCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEKEDTWQELEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRYFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRLDAKPPAVFTRISHYRPWINKILQAN

Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.

P52195

J4UHQ6

OPS1_BEAB2

Oosporein synthase

Beauveria

MPSFFPVFSGLGSGSVFSEENVGRAEENALSPECAVLLQSCHRTFREQVSDAIARNILPEDSIDLDDFAEPASLIRPLSKYSRNVVMQHAALYLHQILAYMTSQKELGNLIGSAGFCTGLLPAAVAAASQTSVITLISQSHHFFQVALWIGIRSEQYRVDHLTNDTQDADGESMLPCSYVLEGVSEAAAQDLLHKTNMGNEVFVSAILSPTRVTISGIPTKLSTFISKHLPANCRTTVAVVHSLYHHESLLEVRNLVMADLERQDTLLQARVELSAPILSTKTGKPLALSSVTTLEQVACAILDLIFIEKVDWLNLQQSIVSHTSQDALDRPINIVNYGPGLGMAPSAFAQAQEKDVCIMDAAKISKGSFQNSGASRLAWDDIAIVGMAVELPGASDADTLWQNLVDGYQACSEIPPSRFNVNDYNNGKGSRTLNTKYGNFLENPFLFDAEHFGISRREAKSMDPQQRILLQTAYRALEDAGYVPDTTTSSARDTFGCWIGNATLDYVDNLRSDIDVYYSTGTLRAFLSARISYVFGWSGPSITLDTACSSSIVALHQAARSILAGDCRSALVGAANTITSPDMYLGLDRAHFLSPSGQCKAFDASADGYCRAEGCGVFVIKRLSDALAEGDRIHGVIKAIEINQSGNTHSITHPHVPTQEALFDKMFRESRINPHEISVVEMHGTGTQAGDPNEVESVRRALCKARSPLNPVYLTSLKANIGHAEAVSGIAGLAKLILMTRNGYIPPQVSLKTLNPRIRPLGVDGAAIDANGTEWPRAGPKKARMSMLNNFGAGGSNAAVIIGEHLSQDESEAQQPACGATIFVCGVSAKNDRALVKLQETVADYLTSAGQSRKPPSLADVCATLTSRRQMYNHRVAVVASSLEELAENLRSASSHNVSKSICEAPEAVFIFSGQGSQYLGMGRELIEQYEDFAHTVNVCDGWLVKNNYPSCLAVITGEQRESEDDKVDAHTWQSFQSAIYVIEVALAKLLESWGIRPQAVAGHSLGEYAALVTAGVIRLMDGLKLVAHRAKLMMEQCDLGQTSMLAVNCSAAVITSIIEASTDFEGLAISCNNSETDCVVGGPVPQLVLLKKHLTDRAQVRSKLLDVPMAFHTAAMDPILEEFTAFAAREVRVFPPTLPVVSNVLGRTVAVGEQAFSPEYFAKQCRGTVAFDDGIKHFLALGDCESTPYRWIEIGPHPSVQPMLRGRLGKAATSHIQLTTLKKNVPPASTLSQLLSHFYQTSSGVNWRSVFSRNAHRRFKLIQLPGMPFFPSEFHVPYREMAGEPASTSQSSGDAASNVVPNSFAVHAIQKLSHGASNSCAIYETPAVLLKEFIEGHLVCGYALCPASVYHEMVLAALNDCQSAAGSSVVWGLSKVSYCAPMVYDGNSNQVLRVVITPRLTLPDRYDFAVMSYVAGTDPNERSTVHCRGVVKQSNMASAELKYSRLQASMKGSMDGLKHVGQLGAPAASCVQVFSKRAMYEKIFTRVVEYSDPYQKVETIRIREDTGEALATCVSPAPYLARDSSIPASHAIFMDVLLHVAGFVSNLNLPNDVMGICKEVGGATTLRAPVVRDGACAPFDVYCSTFDTQDSDGRSFTISNAYAVDSSGVMAVFKGMVFQHVKIPLIEQALKRATRSSPNAAVSASHPAQPKRRNDVTSFVNAQSVERMALPRAAAPVRAAPEVSVPELVAKVCGLDAGQLGVDSRLDAHGVDSLMGIEIAAALSSALGVDVLPDTLGSCDTVGDIERLCEALSPTPVGNDVDNDSPTPGSERGSDSAISTPASVSTVDASSIDMVQIVAELCGARAEAVSPDSELRALGVDSLMFLELADRLQDLDRGIALSSNDLADCQTIGDIERLIVKRPGTPAYQSGISTKIYPEAVHASSEAVRLSAQQPATQISLLASEEAVLPQIERLLHLSQQPEEIQVGSLDRKFSGKSPLFLIHDGSGICTHYRGLRPLGRRVLALHDPKFLIQSSKQRSWASLTTMANEYASSISSTMGMTGGEDCILGGWSFGGVVAFEAARILMSRGHRVKGVVLIDSPPPIGHIPLSESIISAVTAQPAEKDAAAGSTTASKCVSPVASAIRKLVQQSFRICAGLIGDFGTSAELQQRGLSNKPVGPVPRVILLRSAVGWTPPRGYTGAAVEEMENPWLQDRRDRSLATAGWEILTGGPIQCLDIPGNHFQVFDAPNIAAVSAALVDACSEFELK

Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the bibenzoquinone oosporein, a metabolite required for fungal virulence that acts by evading host immunity to facilitate fungal multiplication in insects . The non-reducing polyketide synthase OpS1 produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units . Orsellinic acid is then hydroxylated to benzenetriol by the hydroxylase OpS4 . The intermediate is oxidized either nonenzymatically to 5,5'-dideoxy-oosporein or enzymatically to benzenetetrol by the oxidoreductase OpS7 . The latter is further dimerized to oosporein by the catalase OpS5 . OpS6 probably functions en route for protecting cells against oxidative stress by scavenging any leaked free radical form of benzenetetrol by activating the thiol group of glutathione .

J4UHQ6

B3LTK6

AIM21_YEAS1

Altered inheritance of mitochondria protein 21

Saccharomyces

MPSEVTPKVPERPSRRKTSELFPLSGSESGDIKANSEPPTPAGTPNVPTRRPILKAKTMTSFESGMDQESLPKVPLQRPVRRSTTEELNNVMNNTSKELEEIESLISKHNIHNVSRKKSPTSVEEGKVAAIHQNGQRSASDNKTSTNPSPLEKNEHEGAEGNESAISPSNLVNKSNNEVTEHSDSEDLTEKQKVHAALDNEAGDRSHFEEKLIPGDMKVQVDVSKDVEEGSLNALPPSGITESDDKAEKFTKHPESSLEELQKHQEQQEEKIFQNPTDEESTTSLNEKQEGKDNMEVNSQPQGPSDTETVIAATSSNVPSQIASEEENDVPVIPRSRPKKDFEAHVQKEELPNTQEKRVSEECDSTLISTEEESKIPKIPSERPKRRAPPPVPKKPSSRIAAFQEMLQKQQQQDLHNNGNSSATTASADIAKKHTDSSITSDTTKADFTSKLNGLFALPGMVNPGQLPPSLEKKLSSPDTESKLGPQDQSQAKTGPLGGTRRGRGPRGRKLPSKVASVEKIEEDDNTNKIEIFNNWNVSSSFSKEKVLIDTTPGEQAERALDEKEKLPANAESDPLSQLPQTNTVGNRKAISEESLSPSEAITNRDQNDTTEIQEQQMEEQMEVDMERELSGGYEDVDSALHSEEASFHSL

Involved in mitochondrial migration along actin filaments.

B3LTK6

Q8ZKY3

MNME_SALTY

tRNA modification GTPase MnmE

Salmonella

MSHNDTIVAQATPPGRGGVGILRISGLKARDVAQEVLGKLPKPRYADYLPFKDVDGSALDQGIALWFPGPNSFTGEDVLELQGHGGPVILDLLLKRILTLPGVRIARPGEFSERAFLNDKLDLAQAEAIADLIDASSEQAARSALNSLQGAFSARVNHLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEAQLNGVIADLDAVRTEARQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLRDASDEVERIGIERAWQEIEQADRVLFMVDGTTTDAVDPADIWPDFIARLPKNLPITVVRNKADITGETLGISEVNGHSLVRLSARTGEGIDVLRNHLKQSMGFDTNMEGGFLARRRHLQALAEAAEHLEQGKAQLLGAWAGELLAEELRLAQQSLSEITGEFTSDDLLGRIFSSFCIGK

Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

Q8ZKY3

B9KBJ8

RL1_THENN

50S ribosomal protein L1

Thermotoga

MPKHSKRYLEAKKLVDRTKYYDLDEAVELVKKTATAKFDETIELHIQTGIDYRKPDQHIRGTIVLPHGTGKEVKVLVFARGEKAKEAQEAGADYVGAEDLVEKIEKEGFLDFDVAIATPDMMRVIGRLGKILGPRGLMPSPKSGTVTNEVAEAVKEFKKGRIEVRTDKTGNIHIPVGKKSFDNEKIKENVISAIKQIMQMKPAGVKGQFIKKAVLASTMGPGIKLNLQSILNE

Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

B9KBJ8

C4LGF9

RL9_CORK4

50S ribosomal protein L9

Corynebacterium

MKLILTAAIDNLGVPGDIVEVKAGYGRNYLLPRGYAVPATRGAEKQVQDLKRAQEARAIRDADRAREVKEQLANLEGVSVAVRTANNGKLFGSVKPNDVAQAVVAAGGPELDKHSIDMTKGFVKSTGKYSVDVKLHEDIHGTINFEVVSQ

Binds to the 23S rRNA.

C4LGF9

Q16280

CNGA2_HUMAN

Cyclic nucleotide-gated channel alpha-2

Homo

MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGEDKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAAADEP

Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.

Q16280

P87233

PHF1_SCHPO

PHD finger domain-containing protein phf1

Schizosaccharomyces

MSQKNFFDEGKSYGVNDYAGFHFENGADSSLPQVSAQGVVRETDSSNFDASPVASGSGISDVGPFGADFHQLQQHVQTPYGGMTMPASSSSGATSVPPEQDPSLSVSFNRLPKSASTKTKNGRIRSSRREDDNRIPFYDLDVAEGAEDDLQEDFHVEGMKTKSGRKIQRPVAYNPNATALKRKSRKVDMVTLCSVCQRGHSPLSNRIVFCDGCNSPYHQLCHHPPIDDATVQDVDAEWFCMKCQYRRAKQPLETGMTAQDLGLSESDKKMYLSSLPTPHLADLILFCEKSYPSLPIYNPRTRELLGEIRHQLLVSSERQQISLQERLHAKQDEAPSDEPAPVPYTASYVANSGTLYDYPTLIRLAIRNTLSPSKDEIFNWLAQNVPLLPTFHDSASEAIRWMVNKGQLVRSGSIYQIATVEEYPHLQPSLLPTFQRNRKVPKLVPVSFPTDDPQNLCATVL

Component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Has a role in regulating heterochromatin propagation and euchromatic transcription.

P87233

Q8A011

RF1_BACTN

Peptide chain release factor 1

Bacteroides

MADNSTILEKLDGLVARFEEISTLITDPAVIADQKRYVKLTKEYKDLDDLMKARKEYIQLLGNIEEAKNILSNESDADMREMAKEEMDNSQERLPALEEEIKLMLVPADPQDSKNAILEIRGGAGGDEAAIFAGDLFRMYAKFCETKGWKMEVSNANEGTAGGYKEIVCSVTGDNVYGILKYESGVHRVQRVPATETQGRVHTSAASVAVLPEAEEFDVVINEGEIKWDTFRSGGAGGQNVNKVESGVRLRYIWKNPNTGVAEEILIECTETRDQPKNKERALARLRTFIYDKEHQKYIDDIASKRKTMVSTGDRSAKIRTYNYPQGRITDHRINYTIYNLAAFMDGDIQDCIDHLIVAENAERLKESEL

Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

Q8A011

P61134

CO6_PANTR

Complement component C6

Pan

MARRSVLYFILLNALINKGQACFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCVEKQSKVRSVLRPSQFGGQPCTEPLVAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVCTRKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVGFEVQTAEDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSENINHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETKKRVLFVKKTKVEHRCTTNKLSEKHEGSFIQGAEKSISLIRGGRSEYAAALAWEKGSSGLEEKTFSEWLESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSNAVDGHWGCWSSWSTCDATYKRSRTRECNNPVPQRGGKRCEGEKRQEEDCTFSIMENNGQPCINDDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQLYSVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRRECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPPISNSLTCEKDTLTKLRGHCQLGQKQSGSECICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGSCQDGHQLEWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKMGSSTSEKTLNICEVGTIRCANRKMEILHPGKCLA

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

P61134

A4VMR6

KTHY_PSEU5

dTMP kinase

Pseudomonas

MKGLFVTLEGPEGAGKSTNREYLAERLRARGLDVVLTREPGGTPLAERIRELLLTPADEPMAVDTELLLVFAARAQHLAQVIRPALARGAVVLCDRFTDATYAYQGGGRGLSLERIAQLETFVQGDLRPDLTLIFDLPVDVGLARAAARGRLDRFEQEGMRFFEAVRSAYLQRAEAAPSRYRVIDAGQALNAVQCDVEALIPELLVRLDD

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

A4VMR6

Q9STT2

VPS29_ARATH

Vesicle protein sorting 29

Arabidopsis

MVLVLALGDLHVPHRAADLPPKFKSMLVPGKIQHIICTGNLCIKEIHDYLKTICPDLHIVRGEFDEDARYPENKTLTIGQFKLGLCHGHQVIPWGDLDSLAMLQRQLGVDILVTGHTHQFTAYKHEGGVVINPGSATGAYSSINQDVNPSFVLMDIDGFRAVVYVYELIDGEVKVDKIEFKKPPTTSSGP

Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. Required for the auxin-carrier protein PIN2 sorting to the lytic vacuolar pathway and the PIN1 recycling to the plasma membrane, thus influencing auxin transport orientation . Also involved in the efficient sorting of seed storage proteins globulin 12S and albumin 2S. The VPS29-VPS26-VPS35 subcomplex may be involved in recycling of specific cargos from endosome to the plasma membrane.

Q9STT2

Q9HGM2

GET1_SCHPO

Guided entry of tail-anchored proteins 1

Schizosaccharomyces

MMDLIISTILLSLFIHFFDKFAKKRTIDGAYRIYVSVSNNKDLKKNKEILEQLLTVKKELNATSSQDQFAKWARLNRKYEQLSQEWEKQSANVKIFQDTFKRVLSLFLWILTRGFRFYIQFKESKTPVFFLPAFLLPSWALWVLSLPRSIYGSVSLTVWNFAVQKTISGIF

Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble get3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.

Q9HGM2

Q940B8

KN13A_ARATH

AtKINESIN-13A

Arabidopsis

MGGQMQQNNAAAATALYDGALPTNDAGDAVMARWLQSAGLQHLASPVASTGNDQRHLPNLLMQGYGAQTAEEKQRLFQLMRNLNFNGESTSESYTPTAHTSAAMPSSEGFFSPEFRGDFGAGLLDLHAMDDTELLSEHVITEPFEPSPFMPSVNKEFEEDYNLAANRQQRQQTEAEPLGLLPKSDKENNSVAKIKVVVRKRPLNKKETAKKEEDVVTVSDNSLTVHEPRVKVDLTAYVEKHEFCFDAVLDEDVSNDEVYRATIEPIIPIIFQRTKATCFAYGQTGSGKTFTMKPLPIRAVEDLMRLLRQPVYSNQRFKLWLSYFEIYGGKLFDLLSERKKLCMREDGRQQVCIVGLQEYEVSDVQIVKDFIEKGNAERSTGSTGANEESSRSHAILQLVVKKHVEVKDTRRRNNDSNELPGKVVGKISFIDLAGSERGADTTDNDRQTRIEGAEINKSLLALKECIRALDNDQLHIPFRGSKLTEVLRDSFVGNSRTVMISCISPNAGSCEHTLNTLRYADRVKSLSKSGNSKKDQTANSMPPVNKDPLLGPNDVEDVFEPPQEVNVPETRRRVVEKDSNSSTSGIDFRQPTNYREESGIPSFSMDKGRSEPNSSFAGSTSQRNNISSYPQETSDREEKVKKVSPPRGKGLREEKPDRPQNWSKRDVSSSDIPTLTNFRQNASETASRQYETASRQYETDPSLDENLDALLEEEEALIAAHRKEIEDTMEIVREEMKLLAEVDQPGSMIENYVTQLSFVLSRKAAGLVSLQARLARFQHRLKEQEILSRKRVPR

Internal motor kinesin involved in trichome morphogenesis . Participates in regulating the formation of Golgi-associated vesicles . Plays a central role in microtubule disassembly via the active ARAC10-ICR5 cascade, which establishes the secondary cell wall pattern in metaxylem vessel cells . Acts redundantly with KIN13B to modulate cell wall synthesis and cell expansion via the THE1 pathway .

Q940B8

A5ESR5

Y7345_BRASB

Nucleoid-associated protein BBta_7345

unclassified Bradyrhizobium

MADFLGMMKQAAQLQSKMQAMQEELGSLEVEGISGGGLVAVRMTAKMEVKGIKIDPSLLKPDEAEILEDLLVTAHGDARRKAEAAMQEKMQAITGKLGLPPGFGFG

Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.

A5ESR5

B5VRP4

MDM12_YEAS6

Mitochondrial inheritance component MDM12

Saccharomyces

MSFDINWSTLESDNRLNDLIRKHLNSYLQNTQLPSYVSNLRVLDFDLGKVGPAITLKEITDPLDEFYDSIREEADQETEENNDNKEDSEHICPDRTIANHEGPKDDFEAPVVMPSPNDIQFLLEVEYKGDLLVTIGADLVLNYPVEKFMTLPVKLSISDIGLHSLCIVACLSKQLFLSFLCDVSDPALDDNQTVLDPKGPILAATKPLERISIVRSMKIETEIGEQYQGQGSVLRSVGELEQFLFTIFKDFLRKELAWPSWINLDFNDGDE

Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.

B5VRP4

A1STF0

GCH4_PSYIN

GTP cyclohydrolase FolE2

Psychromonas

MPDIANSAQAQTEGKLDRVGMSNIELPLMVQTDDCPPQQVSANAEVFVNLGDAQAKGIHMSRLYLQLDELSTESELNISTLTALLQGFITSHHELSQRAFVKFSFDYHLRRKSLISEKRGWKAYPVIIIGRLSEGNFEVELQVNVPYSSTCPCSAALARQLIQQAFSQKYDQQTEVNKEEIFAWLGSTKGIVATPHSQRSIVEVKVKLNSLNQSFPIIELIDLIEKTLKTPVQAAVKREDEQEFALLNGQNLMFCEDAARHLQHSLHQETKFDDFWLRVNHYESLHAHDAVAMTTKGIEGGYLA

Converts GTP to 7,8-dihydroneopterin triphosphate.

A1STF0

P24674

RBL_PICPU

Ribulose bisphosphate carboxylase large chain

Picea

MSPKTETKASVGFKAGVKDYRLTYYTPEYQTKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYDIEPVAGEETQFIAFVAYPLDLFEEGSVTNLFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFVFCAEAIYKAQAETGEIKGHYLNATAGTCEEMMKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHGGTVVGKLEGERDITLGFVDLLRDDFIEKDRSRGIYFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEVIREASKWSPELAAACEVWKEIKFEFEAVDTI

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.

P24674

Q8IS20

GEFC_DICDI

RasGEF domain-containing protein C

Dictyostelium

MSVFTFGHGSNGALGLGKITDDTCPTPQKVNYFTEIDKRVKKVACGSYHTVFVTDDEHLYICGIKKDPKHGTTLFYTSPPPTTTTTTTTTSSTSATTTTTNGMVNEKNNNNKNNNGEKIVNSKPESVIIKDGASNTTNDSTSSSSTSTSSLSSSLPPTNIETPRDKKKPPIKLDKGIPHHRSTRELIQRPESPLLNKLLTSKAEMEFKHYESNEKSKDEMKDNENENEEDEDDDDDDSTIRQNEDKESSLIDDNESETSLRINKKDAENITNNIRLIKELDEQQQQPQQPQQNLKGIMNQPPLPTNDDLDEDPNIHFTPIRISTHFLENSPLNTIKQVALGNYHIVLLTEGGNVWTWGSNSNGQLGYLVDTQQQQQQQLQQQQSMSSLQPSASSSSPSSSSLQTTCTPKMVEIKCVKYIATGVKNTAALTEWGELYMWGINEHGELGLGDTIDRRTPTRVIRLKNEVVSTIACSSTHSACYTESGKMYVWGQSDETGKIQAIPSPLPIHSYLDREIKSPNGGGVGGFFGGGGKIKQLACGQRCIAVLTQMGEVFMWEIPGIPIPLRNALENHSVRNIVMGNFHLVCLTDSGEVVTIGRNKTGQLGRTDAENEPGIVKQLSFDPDGLNSDEFVVSIAAGEFHSVALVENTPKTKLALQLVRMQRNYLRQLNILNNIYYKSMMSMASPYDPVVLSMMNNGSASTLPPSLKGLSGGLPDNANNTIKNGKDKDNHHNGDSNGHHSNGHYHGNGNNGNNSITTSNSISSPSLLGSGGTLKSRSASIATIRGLFGINHMLHHSQSQSFQEENSTVTEDEIKEIFSDIEALSKLTEKFLSYLDQRMDNWDPVSKVLGDIFLDEALMAAYRIYIPYSDSYNTSCMTLFNIRRRNERLSNIIKDCEKKSKSFGVKLDQEFVKEIDLKSLLLSPLQNIPRIYILLRELGSDDSGNINPRDIDLINFAATKFQVLLERMNQNFQFVNAVEILHCSSNEYGNPQIMGGSLPQLVDKLTHHNISDPNFRDVFLLTFRAFTTPCNLFDLLVETFQRQKHLKNGRVVNVITSWVVHHFYDFEKDKLSDFTQDPNHNPQLLSEKLEQFIYSEDHQSVSQIKLQYFSHRKRLESSINLIDNQKLTQNEITTPPPLQIQNNNQNNNLENNNNNNNNNNTTTTTTTPNDNINDINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNLTNSTIKLVVQPPIPINFNLLDSQPIEVAQTLTIMDHHYFAMIDKREFLGQRWAKNKSPNIQISTDHFNRTSQVVVTEILKSKNSKQRSATLGYFISVAYCCFELNNLSGTASIIYGLNSASIQRLKKSWSKLPKESMIAFEYLDKIVTPMKNYISLRHLMTTIQPPCVPFLGTYLKDLTFIEEGNPSIIGGLINFYKQRKIAEVIFQIQQHQQVVYSAIRSNPTIKAFLMSSHTFDDKQAQKISSEAE

Promotes the exchange of Ras-bound GDP by GTP.

Q8IS20

A8EVZ6

RL10_ALIB4

50S ribosomal protein L10

Aliarcobacter

MTREEKSQVIDFLTAEFKSSLAVVVCDYKGLTHKELETLRKEAKANNTKVQVAKNTLVTVAVKNAELGDIELSGTNIFLWSDDQISACKVADKFASANKEKFAIKSGIIEGQISDASKVNAFAKLPSREELLGMLASVWMGPVRNFTIGLDALRRKKEEEAA

Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.

A8EVZ6

B9E8Q0

EFTU_MACCJ

Elongation factor Tu

Macrococcus

MAKEKFDRSKTHANIGTIGHVDHGKTTLTAAIATVLSKKLGGEARSYDQIDNAPEEKERGITINTSHIEYETEKRHYAHVDCPGHADYVKNMITGAAQMDGGILVVSAADGPMPQTREHILLSRNVGVPALVVFLNKVDMVDDEELLELVEMEVRDLLSEYDFPGDDVPVIAGSALKALEGVEEYEDKIMELMDAVDEYIPTPERDSDKPFMMPVEDVFSITGRGTVATGRVERGQVKVGEEVEIIGLTEEPSKTTVTGVEMFRKLLDYAEAGDNIGALLRGVSREDVQRGQVLAKPGSITPHTKFKAEVYVLSKEEGGRHTPFFTNYRPQFYFRTTDVTGVVNLPEGTEMVMPGDNIEMNVELISPIAIEDGTRFSIREGGRTVGSGVVSVIEK

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

B9E8Q0

A9AGH3

KYNB_BURM1

N-formylkynurenine formamidase

Burkholderia cepacia complex

MDILWDISPPISAATPVWPGDTPVSVERVWRIEAGSPVNVARLTLSPHTGAHCDAPLHYDADGAAIGAVPLDTYVGPCRVIHCIGASPVVRPADVAAALDGVPPRVLLRTYANAPTAHWDSAFCAVAPDTVDLLAAHGVKLIGIDTPSLDPQESKTMDAHHRVHAHRMAILEGIVLDEVPPGDYELIALPLKFATLDASPVRAVLRALPARAA

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.

A9AGH3

A2Y9X7

PSA4A_ORYSI

20S proteasome subunit alpha-3

Oryza sativa

MSRRYDSRTTIFSPEGRLYQVEYAMEAIGNAGSALGVLAADGVVLVGEKKVTSKLLQTSRSAEKMYKIDSHLACAVAGIMSDANILLNTARLHAQRYALSYQEPIPVEQLVQSLCDTKQGYTQFGGLRPFGVSFLFAGWDKHHGFQLYMSDPSGNYSGWKAAAVGANSQAAQSMLKQDYRDGMTREEAVALALKVLSKTMDSTSLTAEKLELAEVFLQPGTGEVQYQVCSPEAMGKLLAKAGLSQPAPEA

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

A2Y9X7

Q7X7H9

SK3_ORYSJ

Shikimate kinase 3, chloroplastic

Oryza sativa

MDAGVGLRAKPGAWAGLGNPRRSSTARVPVRFAVEKFAQPLVLGSDRRSCGAKLKVSCSRKPAGIDKTYYSADEALVLKQKAEDVVPYLNDRCIYLVGMMGSGKTTVGKILAEVLGYSFFDSDKLVEKAVGISSVAEIFQLHSEAFFRDNESEVLRDLSSMHRLVVATGGGAVIRPINWSYMKKGSTIWLDVPLDALARRIAAVGTASRPLLHQESGDPYAKAYAKLTALFEQRMDSYANADARVSLEHIAVKQGHSNVTTLTPSAIAIEALLKMESFLTEKAMIRN

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.

Q7X7H9

O54908

DKK1_MOUSE

Dickkopf-related protein 1

Mus

MMVVCAAAAVRFLAVFTMMALCSLPLLGASATLNSVLINSNAIKNLPPPLGGAGGQPGSAVSVAPGVLYEGGNKYQTLDNYQPYPCAEDEECGSDEYCSSPSRGAAGVGGVQICLACRKRRKRCMRHAMCCPGNYCKNGICMPSDHSHFPRGEIEESIIENLGNDHNAAAGDGYPRRTTLTSKIYHTKGQEGSVCLRSSDCAAGLCCARHFWSKICKPVLKEGQVCTKHKRKGSHGLEIFQRCYCGEGLACRIQKDHHQASNSSRLHTCQRH

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 . Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity . Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning .

O54908

Q6FKA1

BOS1_CANGA

Protein transport protein BOS1

Nakaseomyces/Candida clade

MNALYIHAQKQKTQLQQDIAKFEQDNLTAPISLQGSISATLVAFEKTIEQYKQHFDKRRAGGSNDEEQLDPKYELRLVSLKKDHKDFDAKFKELKQKYNENNARSKLFESPLDAQTGGESVMNQRRTATNDHTSQPGNTSSNYGLPMYDGLQKEQSIFQRGNAQLDMILEMGQQSLDDIMEQNQILLKVQDQMSRSLRTLGVSEETIQTINKRVFKDKLIFILIIFLFLVGVYYVLKWFR

SNARE required for protein transport between the ER and the Golgi complex.

Q6FKA1

B4SG68

PROA_PELPB

Glutamyl-gamma-semialdehyde dehydrogenase

Pelodictyon

MKETITKQLIAVQQASREIITLTDETINSLLCALADSIPSHQEAILQANQKDIERMDPADPMVDRLLLNASRLDAIAADIRNVASLPSPLDALLEERVLPNGLNLKKVTVPIGVIGIIYEARPNVTFDVFALCLKSGNATVLKGGSDAMYSNIAIVELIHSVLKQHGINPDTLYLLPAEREAAAVMLNAVGYIDMIIPRGSQKLIDFVRNNAKVPVIETGAGIVHTYFDKSGDLDLGKHIIFNAKTRRPSVCNALDTLVIHQERLADLPALVEPLQEKQVMLFADEAAFQALQGSYPDDLLHQAEPEHFGTEFLSLKMSVKTVSSLEEALEHITRYSSRHSEAIIATDPETTATFLKRVDAAVVYANTSTAFTDGAQFGLGAEIGISTQKLHARGPMALKELTTYKWIIEGNGQTRPA

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.

B4SG68

C5CXR6

FLHC_VARPS

Flagellar transcriptional regulator FlhC

Variovorax

MTRKSVLGEVREVQLAIQLIQLGARLQFLESEVGLSRERLIRLYKEIKGVSPPKGLLPFSTDWYMTWLANIHSSMFYNMYQFMKIHSDEEKVWILIKSYKLYLQQIAAQDSEPILDFTRAYTMVRFFDSDMLQLSTCCRCSGQFVAHAHDHKSGYVCVLCRPPSRAGKARGAKRGAEGEAGALGIEGMGFGVEAAPGGAGFH

Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.

C5CXR6

Q556R7

CF50_DICDI

GH family 25 lysozyme 1

Dictyostelium

MNKMNNIFLIISSIILSIVIFVSGECAIDFSSEISVGISDSQWSCLASNNQRVIIQVWSGGGQYNSNISSVVSAAEQAGFDNIDLYAFLCSECDGNYPASSAIQSLVSSLKSDGINFNMLWIDVEQCDGCWGAESDNADYVQEAVETAQGLGVLVGVYSSEGEWPQTVGNLSTLSQYPLWYAHYDDNPSFSDTAFYEFGGWTSPAMKQYIGNTNQCGVSVDLDFYGSGSGCSTSSGSASGSASGSASGSASGSNSGSSNSGSSNSGSSNSGSNSGSSNSGSGNSGSSNSGSASGSGTGSGSSI

Cell-counting factor that limits the maximum size of the multicellular structure during aggregation. Has a very low lysozyme activity.

Q556R7

Q5SID2

TRMFO_THET8

Folate-dependent tRNA(M-5-U54)-methyltransferase

Thermus

MERVNVVGAGLAGSEAAWTLLRLGVPVRLFEMRPKRMTPAHGTDRFAEIVCSNSLGGEGETNAKGLLQAEMRRAGSLVMEAADLARVPAGGALAVDREEFSGYITERLTGHPLLEVVREEVREIPPGITVLATGPLTSEALAEALKRRFGDHFLAYYDAASPIVLYESIDLTKCFRAGRYGQSADYLNCPMTEEEYRRFHQALLEAQRHTPHDWEKLEFFEACVPVEELARRGYQTLLFGPMKPVGLVDPRTGKEPFAVVQLRQEDKAGRMWSLVGFQTGLKWPEQKRLIQMIPGLENAEIVRYGVMHRNTYLNAPRLLGETLEFREAEGLYAAGVLAGVEGYLESAATGFLAGLNAARKALGLPPVAPPEESMLGGLVRYLATANPEGFQPMYANWGLVPPVEGRMGKKEKRQAMYRRGLEAFSAWLSGLNPPLPRPEAALV

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.

Q5SID2

A4SG83

HIS3_CHLPM

Phosphoribosyl-AMP cyclohydrolase

Chlorobium

MGENEGIDKSFLDTVKFDDRGLIPAIVQDHETGKVLMMAWMNRESLEMTLERKKACYWSRSRNKLWLKGESSGNMQEVFDILIDCDGDTLILKVSQIGGACHVGYHSCFYRKVNEDGSMQICDTLMFNPEEVYGKKH

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.

A4SG83

A5EY84

ORN_DICNV

Oligoribonuclease

Dichelobacter

MDKKNNLVWIDLEMTGLDPQHDEIIEIATIVTDAQLNILAEGPVIAVYQPEPILAQMDAWNQKHHGASGLIERVRQSSFNTLEAEAQTLSFLEQYSEKGRSPICGNSICQDRRFLSRLMPRLEAFFHYRNLDVSTIKELVARWYPEHYFHKNTTHQALQDIRDSIDELRHYRQRIFVNPS

3'-to-5' exoribonuclease specific for small oligoribonucleotides.

A5EY84

Q11183

TXND9_CAEEL

Thioredoxin domain-containing protein 9

Caenorhabditis

MAANIQQQFGEQLLRAAQVVEEQIDQEMNKLENLEEDDLEVIRRQRMEQMKKAQKDRIEMLSHGHGKYEEVADEKEFFEATKKSDKVVCLFYLPGNFRCKIVDKHFEILARKHVGTRFIHVNAEKVHFLTTRLNIRVIPSIAIVVKQQTVDYIRGFDELGGKDEFTTETMENRLARSEVLTVEKKHTAPAKKKIIRSGVEEYDNEEDW

Required for normal microtubule organization and function . Regulates tubulin acetylation in ALM and PLM neurons .

Q11183

P95526

RECA_PASMU

Recombinase A

Pasteurella

MATKEEKNKALAAALGQIEKQFGKGSIMKLGDTQALDVEAVSTGSLSLDVALGIGGLPMGRIVEIFGPESSGKTTLTLSVIAQAQKEGKTCAFIDAEHALDPIYAAKLGVNVNELLVSQPDNGEQALEICDALVRSGAVDVIIVDSVAALTPKAEIEGEMGDSHMGLQARLMSQALRKLTGQIKNSNCLVVFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRTGAIKEGEEVIGNETRVKVVKNKVAAPFRQVDFQILYGQGISKTGELIELGVKHKLVDKAGAWYAYNGEKIGQGKANAMKWLEEHPEEALALETKLRNELLANPEKVLAADIAEKNESSTGLEADY

Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.

P95526

Q8DPG6

CRCB2_STRR6

Putative fluoride ion transporter CrcB 2

Streptococcus

MKKEQFYPLGIFLAAMLGGLVRYLVSTWLPASPDFPWGTLFVNYLGIFCLIFLVKGYLVYKGTSKGLILALGTGFCGGLTTFSSLMLDTVKLLDTGRYFSLVLYLLLSIGGGLLLAYFLGRKKW

Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

Q8DPG6

Q7ZWM3

CEL3B_XENLA

Trinucleotide repeat-containing gene 4 protein B

Xenopus

MKEPDAIKLFIGQIPRNLDEKDLKPIFEQFGKIYELTVIKDKFTGMHKGCAFLTYCARESALKAQSALHEQKTLPGMNRPIQVKPADSESRGEDRKLFVGMLGKQQTDEDVRRMFETFGNIDECTVLRGPDGTSKGCAFVKFQTHTEAQAAINALHGSRTLPGASSSLVVKFADTEKERGLRRMQQVANQLGMFSPIALQFGAYSAYTQAVSDQLMQQQAALVAAQSAYLNPMATMAAVQMQQMATINPNGIIATPITQINSITSSSGTSTPPTLTATPVSAIPATLGVNGYSAVPTQSTVQPSSEAIYTNGLHPYPAQSPVAQLDPLQQAYAGMQHYTAAYPAAYGLVSPAFTQPPAILTQQPPQQQQQREGPEGCNIFIYHLPQEFTDSEILQMFLPFGNVISAKVFVDRATNQSKCFGFVSFDNPGSAQAAIQSMNGFQIGMKRLKVQLKRPKDANRPY

RNA-binding protein that may be involved in the regulation of pre-mRNA alternative splicing.

Q7ZWM3

Q8GXF8

SHGR9_ARATH

RING-type E3 ubiquitin transferase SGR9

Arabidopsis

MEDENTTIIMASLSALSPSHLTNLTHSILSISHHHRRRLGAVLSSPTLFSLTLRHLLSLSLPDKTHLIANHLLSLLHPLLIHRKHHSSYAVTMKLRDLDAVVLLLFLCETHQLHPDVLEASADNWREILGNTYSNNMLSNNSGLWTCDAGILMPYIETLVRCKRFVDIMGGYNHLRRRDQKEGYQVPAARAAVVALRAVEVFNVAASNAGEVECVICKEEMSEGRDVCEMPCQHFFHWKCILPWLSKKNTCPFCRFQLPTDDVFSEIQRLWEILVKSSELHVA

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Modulates amyloplast dynamics and sedimentation in statocytes during inflorescence, hypocotyl and root gravitropism, probably by regulating amyloplast interaction with actin filaments (AFs) in endodermal cells.

Q8GXF8

B2VE93

DER_ERWT9

GTP-binding protein EngA

Erwinia

MVPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGRAEIEGREFICIDTGGIDGNEEGVETRMAEQSLLAIEEADVVLFMVDARAGLMPADTAIAKHLRSRQKPTFLVANKTDGLDADSAVVDFWSLGLGEIHPIAASHGRGVTSLLELVLLPWMDEVVPQRELTEEEENAAYWAELAAKEAKVNGEATADEEDDFNPLDLPIKLAIVGRPNVGKSTLTNRILGEDRVVVFDMPGTTRDSIYIPMERDGREYILIDTAGVRKRGKVTETVEKFSVIKTLQAIEDANVVMLVIDAHEGISDQDLSLLGFILNSGRSLVIVVNKWDGLSQEVRDEVKEALDYRLGFIDFARIHFISALHGSGVGNLFESVTEAYDCSTRRVNTSMLTRIMHMAADDHQPPLVRSRRVKLKYAHAGGYNPPIVVIHGNQVKDLPDSYKRYLMNYFRRSLDIMGTPIRIQFKEGDNPYEGKRNLLTPNQQRKRQRLMSHLKKNKR

GTPase that plays an essential role in the late steps of ribosome biogenesis.

B2VE93

Q9CCL1

CTPC_MYCLE

Manganese-exporting P-type ATPase

Mycobacterium

MTLAMAEQIATADNPAFVVVSDAAGRMRIQIEWVRSNPRRAVTVEEAIAKCNGVRVVHAYPRTGSVVVWYSPRCCDRQSILAAISGAAHVAAELIPTRAPHSSDIRNIEVLRMAIGAAALTLLGVRRYVFARPLLLPTTSRLVASGVTIFTGYPFLRGALRFGKTGTDALVSVATIASLILRENVVALAVLWLLNIGEYLQDLTLRRTRRAISALLSGTQDTAWIRLTDGPQAGTEIQVPIGTVQIGDEVVVHEHVAIPVDGEVIDGEAVVNQSAITGENLPVSVMAGSHVHAGSVVVRGRLMVRASAVGKHTTIGRIVTRVEEAQHDRAPIQTVGENFSRCFVPTSFVVSAITLAITKDVRRTMTVLLIACPCAVGLATPTAISAAIGNGARRGILIKGGSHLEQAGRVDAILFDKTGTLTVGRPVVTNIVAMHKDWSPEQVLAYAASSEIHSRHPLAEAVIRSTEERHISIPPHEECEVLVGLGMRTWADGRTLLLGSPSLLCAEKVKVSKTASEWVDKLRHQTETPLLFAVDGTLVGLISLRDEVRPEAAEVLTKLRASGVRRIVMLTGDHPDIAKAVATELGIDEWRAEVMPEDKLKVVRDLQNEGYVVGMVGDGVNDAPALAAADIGIAMGLAGTDVAVETADVALANDDLNRLLDVRDLGGRAVEVIRENYGMSIAVNAAGLFIGAGGALSPVLAAVLHNASSVAVVANSSRLIRYRLD

High affinity, slow turnover Mn(2+) transporting ATPase.

Q9CCL1

A9B8B2

CLPX_HERA2

ATP-dependent Clp protease ATP-binding subunit ClpX

Herpetosiphon

MAQSAFMPPTYYCSFCGRNQDEVDRLVTGPGALFICNECIELLSAIIANEERKEAPHAPILPPTLPIPHAIRDHLDEYVIGQDRAKKVMAVAVYNHYKRLRAQAQGDTDVEIQKSNILLVGPTGSGKTLLAQTLARMLDVPFAIADATALTEAGYVGEDVETILLRLIQAADGDVDRAQMGILYIDEIDKIARKADNPSITRDVSGEGVQQALLKILEGGVVNVPPMPGRKHPQQEFIPFDTTNVLFICGGAFEGLEHHIAERMGSGGTLGFGKTIVKEERLERSKKLLSLVNPDDLLHFGFIPEFIGRMPVVAALTPLDKDAMMRILTEPRNAIIKQYQKMLALDHVQLEVSGDAMEAIVERALAGKTGARGLRTAVEEILLDVMFDLPSETDVVRCVITAETVRDGAMPTLIRRTSSRSRAGKQPTTKAS

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.

A9B8B2

Q89H51

AMIF_BRADU

Formamide amidohydrolase

Bradyrhizobium

MNGLGGLNKSPEGVVIGLVQLQLPNVVTRADLARQTERIVWMVGKARRNLSTMDLVVFPEYSLHGLSMDTNPEIMCRLDGPEVTAFKKACVDNRIWGCFSIMEFNPHGNPYNSGLIIDDHGEIKLYYRKLHPWIPVEPWEPGDIGIPVIEGPKGARIALIICHDGMFPEMARECAYKGAEIMIRTAGYTAPIREAWRFTNQANSFQNLMVTANVCMCGSDGSFDSMGEGMIVNFDGAVLAHGTTGRADEIITAEVRPDLVREARINWGVENNIYQLWHRGYVAVKGGAMDCPYTFMQDMVAGTFRLPWEDQVKVTDGSSCGFPAPTRMYGKTAKAAE

Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide.

Q89H51

O67315

MURA_AQUAE

UDP-N-acetylglucosamine enolpyruvyl transferase

Aquifex

MKNTTLYTYRDYFVIRGGKPLTGKVKISGAKNAALPIMFATILTEEPCTITNVPDLLDVRNTLLLLRELGAELEFLNNTVFINPSINSFITNQEIIRRMRASVLSLGPLLGRFGRAVVGLPGGCSIGARPIDQHLKFFKEAGADVEVREGYVYVNLKEKRRVHFKFDLVTVTGTENALLYLASVPEESILENIALEPEVMDLIEVLKKMGAHVKVEGRSAYVKGSENLKGFTHSVIPDRIEAGTFMVGAVLTDGEILLENARINHLRAVVEKLKLIGGEVVEENGNLRVFRKESLRACDIETQVYPGFPTDMQAQFMALLSVAKGKSRIKENIFEHRFHHAQELNRLGANITVRGNTAYVEGVERLYGSEVYSTDLRASASLVLAGLVAQGETVVRDVYHLDRGYEKLEEKLKKLGADIERVSEL

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.

O67315

O57314

DHB12_ANAPL

Estradiol 17-beta-dehydrogenase 12

Anas

MLPAAGLLWWVGALGALYAAVRGALGLLGALRVWGIGAGRAALGPGLGAWAVVTGATDGIGKAYAKELAKRGMKVALISRSKEKLDQVAGEITEQYGVETKVIVADFGEREDIYDRIRAGLEGLEIGVLVNNVGISYSYPEYFIDVPDLDKTIDKMININIMSVCKMTRLVLPGMLERSKGVILNISSAAGMYPTPLLTLYSASKAFVDYFSRGLHAEYKSKGIIVQSVMPYYVATKMSKISKPSFDKPTPETYVRAAIGTVGLQSQTNGCLPHAFMGWVFSILPTSTVMNLLMKTNKQIRARFLKKKMKEK

Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.

O57314

Q6PGA0

RCOR3_MOUSE

REST corepressor 3

Mus

MPGMMEKGPELLGKSRSANGGAKSPAGGGGSSANGGLHFSEPESGCSSDDEHGDVGMRVGAEYQARIPEFDPGATKYTDKDNGGMLVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEEAHPMDGNDSDYDPKKEAKREGNADQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQKMEGGIEEFKPPEAQTPQAPRTLGPSPPAPSSTPTPTVPIATLNQPPPLLRPTLPAAPALHRQPPPLQQQARFIQPRPTLNQPPPPLIRPANSMPPRLNPRPVLTTVGGQQPPSLIGIQTDSQPSLH

May act as a component of a corepressor complex that represses transcription.

Q6PGA0

Q3YZN3

MEPA_SHISS

D-alanyl-D-alanine-endopeptidase

Shigella

MNKTAIALLALLASSASLAATPWQKITQPVPGSAQSIGSFSNGCIVGADTLPIQSEHYQVMRTDQRRYFGHPDLVMFIQRLSSQVSNLGMGTVLIGDMGMPAGGRFNGGHASHQTGLDVDIFLQLPKTRWTSAQLLRPQALDLVSRDGKHVVSTLWKPEIFSLIKLAAQDKDVTRIFVNPAIKQQLCLDAGTDRDWLRKVRPWFQHRAHMHVRLRCPADSLECEDQPLPPSGDGCGAELQSWFAPLKPGTTKPEKKTPPPLPPSCQALLDEHVI

Murein endopeptidase that cleaves the D-alanyl-meso-2,6-diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus.

Q3YZN3

Q393X2

LEUC_BURL3

Isopropylmalate isomerase

Burkholderia cepacia complex

MAQTLYDKLWNTHVVHTEEDGTTLLYIDRQLLHEVTSPQAFEGLKIAQRPVWRISANLAVSDHNVPTTDRSHGIADPVSKLQVDTLDANCDAFGITQFKMNDVRQGIVHIIGPEQGATLPGMTIVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQTLLQKKSKNMLVKVEGTLPRGCTAKDIVLAIIGKIGTAGGTGYAIEFGGSTIRALTMEGRMTVCNMAIEAGARAGMVAVDDTTIDYLKGRPFVPTGAEWNQAVEYWRQFKSDDGAQFDRVVELNAAEIVPQVTWGTSPEMVTSIDGRVPDPEREKDPVKRDAMERALAYMALEPNTPIESIKVDKIFIGSCTNARIEDIRAAAYVVKKLNRRVASNVRLAMVVPGSGLVKAQAEREGLDKVFTDAGFEWREPGCSMCLAMNADRLDPGERCASTSNRNFEGRQGAGGRTHLVSPAMAAAAAIEGHFVDIRQLG

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

Q393X2

Q6NMI3

COG6_ARATH

Component of oligomeric Golgi complex 6

Arabidopsis

MASTVGLAPGLSRKLKKVLDCRTDSPDLVASLNALSSFYDENSAHARRNLRSTIEKRALQINSEFLNAADSTQIALDRVEEEVNALADCCDKIAAALSSSAATTSDIISTTERLKQELEVTTQRQEIVNCFLRDYQLSNEEIKALREDELNENFFQALSHVQEIHSNCKLLLRTHHQRAGLELMDMMAVYQEGAYERLCRWVQAECRKLGDTDNPEVSELLRTAVRCLKERPVLFKYCAEEVGNLRHNALFRRFISALTRGGPGGMPRPIEVHAHDPLRYVGDMLGWLHQALASERELVHALFDIDSADHQSNAKNTSENIALKAGESDFTFVLDRIFEGVCRPFKVRVEQVLQSQPSLIISYKLTNTLEFYSYTISDLLGRDTALCNTIGMVKDAAQKTFFDILKTRGEKLLRYPPPVAVDLSPPPAVREGVSLTLEIIENYNSMMVSASGEKPAFDPVLSALLDPIIKMCEQAAEAHKSKKSGQLPRRSRTSSDSSQLTSVDALLSSSPSPPQNNETPSKIFLINCLCAIQQPLLRHDVASQYVTNIGLMIENHINLLVQNEVDTLLHKCGLSDKMQIFRSSTSELPLSERQDTSPAMLSECLKAFFGLVLGSEGSLPEFEQIQVPKLRSEACVRVAKTLAEAYEVIYQAVTDQQNGYPDPKSLARHPPDQIRTILGI

Required for normal Golgi function.

Q6NMI3

B9L7B6

THIG_NAUPA

Thiazole synthase

Nautilia

MSDILKIGKYEFTSRLIVGSGKYPDFQTTRDATLASGAEMITVAVRRVNIMDPNEENLMDYFKDTDVKILPNSAGCTTAEEAITLFRLVREATGIDIIKLEVIGDTAKTLYPDVMETLKACEVLAKEDFTIMAYTNDDPIMAKRLENAGAHAVMPLAAPIGSGLGVQNRYNVVFVKDAVNVPVIVDAGIGTASDAAVAMELGADGVLTNTAIAQAKNPIAMAEAMKHAVIAGRMAYKAGRIPKKPYATASSPLEGLIEF

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.

B9L7B6

A2BTN6

TIG_PROMS

PPIase

Prochlorococcus

MAKDALIVKTTPLPQSRISFELEIPSETCKTCVNETINSISRSAKIPGFRLGKIPKQVLIQRIGITQLHASALEKIIDKSWQEALKIKSIEPLSEPELVDGFESLLAKFSPEKSLKVTLQTDVAPELKLKKSKGLSVEISKTKFDPKSIDEALEKSRNQFANIIPVTNRAAKLGDIAVVSFKGKYKDSGKEIDGGTSESMDLELEKNKMIPGFVEGIVKMKIGDTKTLNLKFPDDYSHEDSRGKEAIFEVNLKDLKEKELPELNDDFAKQSGNKESLKELKKDIEKQLKDNFEKTQKDIKIEALLDALTNELVAEIPKSMIDIEVRNNIEQTAQRFAQQGLDVKSTFTPELVKSLADSTRPQAEKNVQRNLALKALAETENIKVEQDEIDSKMKDYEDAISQSSKQIDIKKLTEVLTNDLLKEKLIIWLEENSEVKEKTTKTSKATKTSKTTKATKTASKTTKTTKTQNKKEKK

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

A2BTN6

B7HLH4

TRMD_BACC7

tRNA [GM37] methyltransferase

Bacillus cereus group

MKIDILTLFPDMFTGVFGSSILKKAQEKEAVELRVVNFRDYTTSKHNSVDDYPYGGGAGMVLTPQPIFDAVEDLTKETERKPRVVLMCPQGERFTQKKAEELAEEEHLIFVCGHYEGYDERIREHLVTDEISIGDYVLTGGELASMVITDSVVRLLPGVLGNHASQVEDSFSTGLLEHPHYTRPADFRGMKVPDVLMSGNHKNIDEWRHKESLRRTYTRRPDLLEERELSKQEKKWLEQIKEGK

Specifically methylates guanosine-37 in various tRNAs.

B7HLH4

Q82U05

FABZ_NITEU

Beta-hydroxyacyl-ACP dehydratase

Nitrosomonas

MKQGDRQTVMDIHEILKYLPHRYPLILVDRVVSLESGKRIHAYKNVSINEPYFSGHFPHHPVMPGVLIIEALAQAAALLTIRSENMEKDNGQVYYFVGIDAVRFKKPVIAGDQLVLKVEITRQLKGIWKYAACAEVDGQVVTEAQLMCTARAI

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

Q82U05

A6TDB1

COBQ_KLEP7

Cobyric acid synthase

Klebsiella

MTLAVMLQGTASDVGKSVLVAGLCRIFHQDGLRTAPFKSQNMALNSGITPDGKEMGRAQIFQAEAAGIAPDVRMNPILLKPTSDRQAQVVLMGQVATSMDAVSYHQYKPRLREQILAVYQSLAGEYEALVLEGAGSPAEINLRDRDIVNMGMAEMAQCPVILVADIDRGGVFAAIYGTLALLQPQERARVKGVIINKFRGDVALLRSGIEQIEALTGVPVLGVMPWLDVDLEDEDGVALQAGKYHRTDRRDIDIAVVHLPHIANFTDFNALAAQPDVRVRYVRDPQALADADLVILPGSKNTLGDLCWLRESGMAHAVEQARQRKVPLLGICGGYQMLGETIIDEVESGLGAQPGLGVLKTVTHFAQHKTTTQVQATLGSALPDWLADAAGLRVSGYEIHMGETRREAGCPPLLQLHKAGQAVDDGAISDDGLAFGTYLHGLFDSDAFTRALLNGLRQRKGLAPLDSALEYARYKTRQFDRLAEAMREHIAIDKIYAIMRQHQEPLC

Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

A6TDB1

Q92HH1

PRIA_RICCN

ATP-dependent helicase PriA

spotted fever group

MRIAKILLPVAKLFPLDYLIPEDLELNIGDLVVVPFRNKELTGIVWELVSNSEAKKIKTIRVKVPLNLNITSEVLELIKWMSSYYMSELGSIAKLVLPMDIAEKPIKVKEQKVNNNFVLPDLSEEQKQAVTILNESNKPTLVKGVTGSGKTEIYFHLIADYLAKGKQVLVMLPEIALSTQIINRFIERFGFEPIIWNSSVTKAHKKMILRGILSDKVKVVIGARSSLFLPFKNLGLIVIDEEHDDSYKQDDGILYNARDTAIVRGTFDKAQIVLCSATPSIETIHNIEIGKYQLVTLVNRYKNVDLPNIEIIDMTKEKLSKNSYLSKLLIEAIKGNLDNKKQVLLFLNRRGYAPLMLCKACGYRLTCKFCSSWMVVHKATKKLECHHCGYQSKIFSSCPECLEDETLTICGPGIERIEEEAKALFPESKIAVISKDHAKSPEKIAQLLHQMENLEIDILIGTQIITKGYHFPNLTLVGVIDADLGSNNADLRASERTFQLLHQVGGRAGRGDSKGVVYLQSYYPDNTIFSYVKAGDEDSFFANELEIRKSADMPPFSKTASVILSGSSEAKILEIARDMVRIAPKANVKILGPASSLMSKLAGKYRYRILIIANKKFNLQKYLKFWLSLIKIPSFCHLKIDIDPKSFY

Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

Q92HH1

Q496J9

SV2C_HUMAN

Synaptic vesicle glycoprotein 2C

Homo

MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDYYPAGETYNGEANDDEGSSEATEGHDEDDEIYEGEYQGIPSMNQAKDSIVSVGQPKGDEYKDRRELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPDTRTQVLM

(Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); note that type D does not usually infect humans.

Q496J9

Q3APJ2

RL15_CHLCH

50S ribosomal protein L15

Chlorobium

MNLSSLRPAKGSVRNKKRVGRGQGSGNGTTAGKGNKGQQARSGYKRPIIEGGQVPVYRRLPKFGFTSRSRKTITTINLLQIEQWLEQGVVSNELTVQDFKTLLHASNTDYFKVLGAGEVTQPITITAHFFSKSAEEKIAAAGGKTIIAFRTLAEAVNIKGLPIEEALLKEKVKLVKVKKAKPTA

Binds to the 23S rRNA.

Q3APJ2

Q92CH2

MURI_LISIN

Glutamate racemase

Listeria

MKQAIGFIDSGVGGLTVVREVLKQLPHEQVYYLGDTARCPYGPRDKEEVAQFTWEMTNFLVDRGIKMLVIACNTATAAALYDIREKLDIPVIGVIQPGSRAALKATRNNKIGVLGTLGTVESMAYPTALKGLNRRVEVDSLACPKFVSVVESGEYKSAIAKKVVAESLLPLKSTKIDTVILGCTHYPLLKPIIENFMGDGVAVINSGEETASEVSALLDYHNLLDATDDEIEHRFFTTGSTQIFKDIAKDWLNMPDMTVEHIKLGK

Provides the (R)-glutamate required for cell wall biosynthesis.

Q92CH2

B0TAH2

DUT_HELMI

dUTP pyrophosphatase

Heliomicrobium

MKVQIKRLHPEAMIPERQTKLASGFDLHVLDAVLPENASDPYYDHFEAIRIFPGERILVRTGIAIQMGEGMEAQVRPRSGLALRHGITLLNSPGTVDADYTGDVGVILINLGDKHVDIRKKDRVAQLVFQPVFHQVELEERESLNETERGDGGFGHTGVNSQP

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

B0TAH2

Q9JZG6

CRCB_NEIMB

Putative fluoride ion transporter CrcB

Neisseria

MLSNIIPLSIGAALGATARWLLNLAVPASIPPATGNLFANWIGAFLIGIFAETVNHPQWKLLLITGFLGSLTTLSGFSLETVTLLQLNRPASALANIFLHTAGSLLLTWLGLKIGAAVK

Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

Q9JZG6