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933
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In addition, immunological memory in the form of opsonizing antibody certainly plays an important role in the early uptake of Salmonella by macrophages and DC. This may be beneficial, as the live bacterial vector used for delivery purposes harbours mutations in genes encoding proteins responsible for their survival in the animal host. This not only encumbers their ability to cause disease, making them safe live vectors, but also limits the number of replications. The presence of opsonizing antibodies should mean a higher level of bacterial uptake, leading to higher presentation to the immune system and therefore a better immune response. | 28,136 | 29,069 | [
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
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1,
1,
1,
1,
1,
1,
1,
1,
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1,
1,
1,
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1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | the much higher fre-
quency of complicated, severe, and fatal cases in the last 2
waves. | 10,785 | 10,873 | [
0,
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0,
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0,
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] |
[
1830,
860,
2245,
6114,
275,
13259,
59225,
2327,
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35654,
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2214,
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7499,
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626,
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928,
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1121,
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40144,
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204,
696,
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19469,
28,
26,
35048,
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22672,
9384,
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193,
34729,
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32067,
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1546,
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193,
12053,
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47115,
27717,
9242,
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304,
532,
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1316,
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14830,
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7305,
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2115,
5632,
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29346,
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52560,
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5632,
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21412,
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2220,
18074,
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59225,
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53758,
566,
6594,
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1104,
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62663,
5163,
376,
82,
280,
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1592,
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2606,
942,
23,
10178,
23,
585,
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17839,
345,
267,
8738,
1190,
1766,
335,
7117,
28687,
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566,
6594,
31406,
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427,
3692,
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626,
31,
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3242,
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626,
33,
273,
24340,
271,
241,
12445,
10776,
5665,
24,
5280,
10888,
688,
555,
18952,
57903,
204,
19,
12527,
24,
92,
31924,
770,
1241,
248,
409,
4652,
30,
10591,
345,
241,
2865,
25,
605,
398,
7790,
325,
204,
2102,
25,
32,
16,
204,
19,
16790,
26,
53758,
20
] | [
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1,
1,
1,
1,
1,
1
] | nine species | 3,868 | 3,880 | [
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[
1562,
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16457,
17965,
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31924,
1042,
312,
272,
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4048,
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1,
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1
] | Fgl2 depletion | 843 | 857 | [
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1
] | viruses that induce strong type 1 inflammation and cell death such as IFV (Yan et al., 2016; Guibas et al., 2018) and certain CoV (including the recently emerged COVID-19 virus) | 19,859 | 20,036 | [
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] | 49.2% | 1,180 | 1,185 | [
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] |
[
5540,
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772,
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2914,
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] | [
1,
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1,
1,
1,
1,
1,
1,
1
] | nothing
can yet be said about whether the first (spring) wave, or for
that matter, the third wave, represented circulation of the
same Virus or variants of it | 14,163 | 14,320 | [
0,
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1,
1,
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1,
1,
1,
1,
1,
1,
1,
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30500,
272,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
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1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | neuraminidase inhibitors | 2,189 | 2,213 | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
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] |
[
1830,
860,
6362,
2913,
362,
629,
312,
5310,
23076,
12309,
19029,
42,
487,
2653,
4121,
277,
268,
10438,
275,
62855,
311,
49010,
273,
2254,
3752,
250,
257,
1482,
5955,
23476,
15157,
14510,
1542,
24290,
9133,
317,
34021,
272,
248,
7980,
438,
8414,
193,
193,
12659,
7561,
17794,
25,
17747,
6825,
25,
24084,
88,
25,
6298,
83,
25,
16162,
26,
4111,
78,
26,
34067,
26,
7141,
46,
38587,
56864,
33,
26,
193,
193,
40853,
37,
261,
27,
77,
28,
7427,
24564,
49757,
31,
77,
5831,
78,
38206,
34,
79,
5367,
78,
3668,
76,
38490,
30,
81,
34,
80,
39406,
30,
76,
193,
193,
43382,
37,
4389,
1264,
320,
5732,
24,
54,
20791,
23,
4666,
1317,
38,
46807,
318,
24,
11635,
6495,
23,
1848,
19295,
38,
531,
48465,
23,
4833,
80,
38,
7971,
81,
23,
27429,
38,
7971,
81,
23,
10777,
38,
17658,
327,
2710,
23,
24935,
38,
814,
320,
464,
5146,
23,
20529,
38,
1154,
340,
686,
23,
2641,
24,
48693,
38,
897,
1548,
23,
59483,
38,
28319,
14231,
23,
39073,
38,
337,
1670,
327,
87,
24,
7066,
524,
14231,
23,
31177,
38,
25111,
307,
44555,
23,
12116,
438,
193,
7499,
37,
204,
626,
32,
24,
3881,
24,
3739,
193,
40144,
37,
204,
696,
25,
19469,
28,
26,
35048,
25,
45707,
25,
24445,
58348,
31,
193,
34729,
37,
32067,
24,
1546,
193,
193,
12053,
37,
41569,
51834,
37,
2254,
3752,
250,
257,
304,
241,
31627,
8147,
273,
34925,
14625,
312,
248,
2820,
275,
13149,
7418,
13930,
18732,
11576,
25,
1130,
11576,
5229,
431,
23076,
6429,
362,
1764,
13998,
431,
11576,
335,
599,
13930,
17436,
248,
5777,
275,
241,
2005,
4630,
24,
40395,
9133,
14625,
335,
248,
25504,
4109,
44337,
22961,
504,
3534,
2879,
312,
248,
2820,
275,
13930,
11576,
25,
7947,
23,
248,
5777,
275,
248,
2005,
4630,
24,
40395,
9133,
4800,
62855,
311,
49010,
1774,
335,
953,
3752,
250,
257,
272,
241,
28313,
6742,
312,
919,
4121,
277,
268,
2859,
398,
16306,
272,
24,
13636,
290,
273,
272,
24,
97,
5299,
25,
8158,
45203,
3691,
2040,
378,
18839,
25409,
37,
703,
1049,
272,
24,
13636,
290,
325,
953,
3752,
250,
257,
273,
62855,
311,
49010,
714,
42318,
15157,
1542,
1988,
23076,
317,
6429,
20895,
204,
19,
51,
28,
57,
28,
19,
3614,
20,
91,
31942,
23,
370,
30,
57,
29,
23,
370,
32,
57,
28,
23,
370,
34,
57,
34,
691,
10299,
23,
360,
11021,
272,
241,
33262,
23076,
2308,
335,
241,
1958,
2895,
15824,
370,
34,
57,
34,
6429,
204,
19,
7035,
8285,
3236,
271,
248,
927,
715,
23076,
317,
19,
51,
34,
57,
36,
20,
6429,
20,
273,
241,
370,
28,
57,
28,
19,
3614,
20,
91,
31942,
23076,
6429,
272,
319,
5831,
14961,
26,
33,
14672,
325,
248,
6725,
745,
275,
1216,
15199,
6302,
7398,
11461,
275,
13275,
5632,
272,
8268,
335,
1216,
40443,
24,
1410,
1696,
424,
379,
28827,
25,
3848,
628,
1517,
23,
414,
4210,
304,
11131,
830,
635,
248,
2820,
5766,
510,
271,
204,
7428,
2155,
1106,
7228,
25,
9449,
38610,
2917,
37,
317,
31003,
9687,
9346,
953,
3752,
250,
257,
273,
62855,
311,
49010,
808
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
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1,
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1,
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1,
1,
1,
1,
1,
1,
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1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | Worldwide, annual epidemics result in about three to five million cases of severe illness | 2,751 | 2,840 | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
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1,
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1,
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3530,
24,
660,
272,
3603,
25,
47243,
23,
28961,
63,
25409,
23,
6915,
39659,
2330,
3691,
61620,
37,
735,
3517,
24,
49917,
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6414,
24,
3039,
23,
4145,
24,
2266,
249,
1598,
2220,
8351,
23041,
1211,
273,
4837,
1242,
13650,
427,
204,
9931,
34,
1242,
1146,
4862,
272,
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3317,
11742,
427,
3675,
204,
2237,
23,
204,
905,
27,
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271,
4286,
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30,
23,
204,
905,
27,
23,
272,
3603,
25,
2824,
1146,
4862,
272,
11742,
10236,
335,
16026,
21632,
379,
46573,
312,
2634,
335,
3530,
24,
660,
646,
9057,
25,
7243,
1287,
22867,
16246,
2174,
6915,
13110,
2289,
30495,
37,
390,
4376,
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5699,
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9319,
23,
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35687,
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18069,
398,
17552,
431,
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5506,
8201,
275,
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36,
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19363,
2824,
16496,
18763,
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248,
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34,
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4860,
1190,
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5588,
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4545,
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36926,
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14854,
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3306,
25,
34,
7278,
646,
12507,
204,
2126,
271,
204,
1738,
909,
23
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] | among frontline vs second-line workers: 6.0 [2.0-11.0] vs 4.0 [1.0-8.0]; P < .001 | 2,634 | 2,715 | [
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] |
[
1562,
304,
248,
44940,
2397,
312,
331,
8494,
24,
857,
65,
42,
16591,
8200,
26084,
571,
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48574,
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6733,
32225,
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21763,
24,
13455,
4745,
427,
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15258,
30826,
13170,
21763,
193,
193,
12659,
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17794,
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17747,
6825,
25,
24084,
88,
25,
6298,
83,
25,
16162,
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4111,
78,
26,
34067,
26,
7141,
46,
39795,
60167,
33,
26,
193,
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40853,
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1159,
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81,
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43382,
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311,
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696,
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59178,
58619,
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772,
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56,
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31876,
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1764,
2661,
25,
6928,
23,
248,
13071,
275,
16065,
2913,
325,
724,
413,
2712,
8618,
275,
1003,
14865,
345,
2913,
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24,
12443,
304,
3978,
25,
2071,
23,
248,
1059,
4671,
304,
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9135,
783,
2634,
788,
596,
23041,
20306,
25,
390,
3415,
275,
783,
20306,
504,
416,
5903,
650,
18074,
272,
16570,
20295,
23,
273,
12526,
23,
414,
2220,
10806,
271,
5557,
612,
25,
63968,
62,
37,
605,
398,
241,
16291,
1092,
24,
3039,
2220,
23,
312,
585,
1211,
427,
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2724,
275,
204,
1871,
23,
44405,
16065,
2634,
272,
382,
15258,
30826,
273,
1031,
1199,
524,
306,
8943,
646,
17352,
427,
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204,
626,
34,
1725,
3960,
204,
626,
34,
271,
11048,
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22082,
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24,
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2369,
16065,
2913,
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5017,
2879,
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2481,
4561,
3236,
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15355,
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10613,
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16042,
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27,
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7278,
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13584,
2196,
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16,
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14702,
20,
618,
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1726,
2521,
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5367,
25,
1871,
909,
204,
19,
8711,
22341,
204,
1671,
25,
35,
691,
20008,
204,
4821,
25,
29,
16,
275,
248,
7805,
2913,
646,
12507,
1192,
204,
5205,
273,
204,
1938,
909,
273,
544,
204,
4467,
16,
275,
7805,
2913,
618,
525,
16065,
38548,
7636,
272,
248,
3550,
25,
390,
2220,
6935,
1373,
2589,
273,
5907,
64765,
312,
15355,
275,
248,
3783,
37,
267,
2521,
1192,
204,
5205,
273,
204,
1938,
909,
23,
4983,
7952,
23,
273,
3550,
2120,
12756,
25,
9449,
38610,
2917,
37,
390,
2220,
2665,
3941,
325,
248,
331,
8494,
24,
12443,
21586,
272,
248,
2828,
8943,
504,
2005,
9031,
325,
1295,
733,
2108,
3618,
312,
248,
12166,
273,
2579,
275,
963,
241,
40610
] | [
1,
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[
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62248,
2804,
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13372,
9533,
16302,
1192,
3895,
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] | Because plaque assays restrict viral transmission neighbor-to-neighbor in two-dimensional cellular space | 11,105 | 11,209 | [
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] |
[
1562,
304,
248,
1966,
275,
248,
1539,
2220,
42,
27122,
369,
60026,
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20963,
273,
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48574,
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57769,
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516,
81,
28,
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30649,
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18637,
50566,
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43382,
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24,
3614,
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1121,
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40144,
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696,
25,
13200,
32,
26,
626,
30,
26,
5387,
63751,
193,
34729,
37,
32067,
24,
1546,
193,
193,
12053,
37,
390,
2138,
275,
5946,
3988,
24,
42973,
23,
44337,
7836,
1542,
370,
32,
57,
28,
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304,
42803,
2434,
25,
529,
414,
2220,
23,
360,
16306,
248,
9407,
60026,
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3204,
273,
13446,
1334,
275,
399,
842,
40351,
38107,
387,
1589,
381,
5682,
33700,
8416,
456,
204,
19,
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20,
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248,
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32,
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28,
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25,
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24,
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123,
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273,
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345,
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431,
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31924,
273,
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25,
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241,
11232,
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23,
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277,
268,
6354,
275,
399,
2992,
388,
241,
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13149,
22961,
2105,
204,
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1754,
539,
56480,
312,
49011,
97,
36456,
23,
725,
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1830,
860,
275,
612,
362,
2895,
15824,
312,
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42,
51,
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36456,
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31470,
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18067,
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40740,
11799,
26588,
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17747,
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4111,
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34067,
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31407,
48120,
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81,
53597,
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18637,
49706,
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1452,
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32989,
3091,
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6021,
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2733,
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14352,
41921,
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48150,
39324,
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1428,
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2895,
15824,
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2887,
19584,
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12905,
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31470,
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2315,
13675,
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17303,
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59225,
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16743,
3963,
770,
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1276,
27637,
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758,
2260,
13149,
1040,
18072,
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1192,
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1067,
16,
273,
204,
1738,
7040,
48749,
39265,
273,
4840,
24,
10170,
25651,
48816,
23,
4428,
1497,
5844,
1623,
23,
362,
2369,
248,
4561,
325,
724,
413,
4044,
248,
2079,
1329,
286,
1108,
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24454,
3963,
1192,
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1840,
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1652,
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703,
1878,
967,
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2360,
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5943,
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40740,
35688,
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627,
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5903,
476,
50478,
8584,
23,
273,
2369,
612,
23,
11525,
725,
2227,
7074,
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2846,
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9973,
10213,
20746,
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15471,
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19243,
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] |
[
1562,
44337,
9203,
362,
1042,
312,
35063,
319,
7228,
42,
44,
1966,
8230,
11430,
1587,
31535,
312,
35063,
319,
6429,
11430,
2691,
23825,
193,
193,
12659,
7561,
17794,
25,
17747,
6825,
25,
24084,
88,
25,
6298,
83,
25,
16162,
26,
4111,
78,
26,
34067,
26,
7141,
46,
11127,
25735,
34,
26,
193,
193,
40853,
37,
293,
80,
35,
79,
4448,
24047,
41785,
1377,
3287,
31,
78,
43222,
32,
21981,
29,
308,
35,
76,
5070,
23446,
30,
79,
56970,
27,
193,
193,
43382,
37,
378,
2309,
812,
23,
2254,
1930,
38,
6299,
322,
7734,
23,
54794,
38,
48181,
23,
22173,
38,
28915,
323,
3930,
23,
63852,
7734,
38,
29994,
7539,
5783,
246,
969,
23,
10617,
38,
56643,
303,
23,
7755,
16337,
38,
4963,
1480,
23,
56784,
38,
367,
2265,
17402,
23,
319,
8413,
11149,
38,
526,
518,
2231,
23,
20636,
38,
7565,
286,
412,
23,
6450,
10950,
193,
7499,
37,
204,
853,
34,
24,
4328,
24,
1067,
193,
40144,
37,
204,
696,
25,
15711,
33,
26,
20596,
30,
24,
35767,
99,
24,
31,
24,
2552,
193,
34729,
37,
32067,
24,
1546,
193,
193,
12053,
37,
41569,
51834,
26,
44,
4400,
37,
390,
2836,
275,
1490,
7552,
20343,
272,
35063,
319,
6429,
204,
19,
16743,
65,
20,
7228,
304,
18256,
8809,
25,
16444,
23,
629,
304,
4259,
1378,
272,
2655,
2691,
248,
11430,
2691,
23825,
272,
248,
19003,
275,
24454,
65,
24,
52434,
2634,
25,
15051,
8230,
44871,
413,
650,
8626,
1042,
271,
10734,
11430,
2691,
24325,
9545,
1542,
241,
2393,
275,
1462,
24,
2586,
6828,
40511,
17436,
25,
12573,
313,
248,
3050,
2138,
275,
241,
24454,
65,
2324,
3922,
1092,
1241,
248,
2375,
10576,
204,
29,
462,
49,
51,
24,
28,
24,
288,
1950,
23,
360,
4027,
241,
1966,
8230,
31535,
312,
24454,
65,
24,
44373,
2691,
23825,
25,
63968,
62,
37,
390,
1966,
8230,
31535,
398,
1934,
313,
241,
3304,
10333,
27531,
27099,
1587,
31535,
272,
585,
9407,
434,
2424,
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1
] | HIV-1 RT-LAMP assay | 1,334 | 1,353 | [
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1079,
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248
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1
] | tyrosine phosphatases, serine/threonine phosphatases, and dual-specificity phosphatases (DUSPs) | 3,672 | 3,767 | [
0,
0,
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] | Recent data suggest that there has been a 25% decrease in the incidence of pneumonia, from 0.29 episodes per child year in low-and middle-income countries in 2000, to 0.22 episodes per child year in 2010 [3] . This is substantiated by a 58% decrease in pneumonia-associated disability-adjusted life years between 1990 and 2013, from 186 million to 78 million | 2,356 | 2,714 | [
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