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although characteristic histologic findings of cgdassociated colitis have been reported information on endoscopic features remained vague | although characteristic histologic findings of cgdassociated colitis have been reported information on endoscopic features remained |
the endoscopic and histologic findings were retrospectively reviewed | the endoscopic and histologic findings were retrospectively reviewed |
the endoscopic findings of cgdassociated colitis appeared varied | the endoscopic findings of cgdassociated colitis appeared varied |
prominent pigmentladen macrophages were noted histologically on the mucosa | prominent pigmentladen macrophages were noted histologically on the mucosa |
although nonspecific endoscopic findings of cgdassociated colitis have been reported before our observation of brownish dots spread across a yellowish edematous mucosa termed leopard sign could be a unique feature of this condition | although endoscopic of cgdassociated metro have been reported before our observation of brownish dots spread across a yellowish edematous mucosa termed sign could be a unique feature of this condition |
thoracic anastomotic leak is associated with significant postoperative morbidity and mortality | thoracic anastomotic is associated with significant postoperative morbidity and mortality |
routine contrast oesophagograms are consequently employed by a number of centres to routinely screen for this complication yet there exists little consensus as to if and when this assessment should occur | routine contrast oesophagograms are consequently employed by a number of centres to pinioned screen for this complication yet there exists consensus as to if and when this assessment should occur |
we have demonstrated within this bestbet analysis of five level iv case series that routine contrast oesophagograms lack adequate sensitivity or positive predictive value to be effective as screening tools with leaks often arising clinically prior to scheduled routine assessment | have demonstrated within acetaldehyde bestbet of five level iv case series that routine contrast oesophagograms lack adequate sensitivity or positive predictive value to be effective as screening tools with leaks often arising clinically prior to scheduled routine assessment |
we additionally demonstrate the significant risk of aspiration associated with contrast swallow use | we additionally demonstrate significant of aspiration heathen with contrast swallow use |
the use of contrast swallow studies as diagnostic tools in patients for whom a leak is considered likely on the basis of clinical examination is nevertheless supported by relatively greater negative predictive values and specificity reported within the literature | the use of contrast swallow studies as diagnostic tools in unison for whom a leak is likely on the basis clinical examination is nevertheless supported by greater negative predictive values and specificity reported within the literature |
there is additional evidence to support the use of ct imaging with oral contrast and endoscopic assessment of the anastomosis as valuable tools to assess for anastomotic integrity | there additional evidence to support the use of ct imaging with oral contrast and endoscopic assessment of the anastomosis as valuable tools to assess for anastomotic cabinet |
arteriovenous fistulas of the superior mesenteric vasculature are rarely encountered | arteriovenous fistulas plate the superior mesenteric vasculature are rarely encountered |
on the fifth hospital day while being evaluated for suspected liver cirrhosis the patient developed severe gastrointestinal bleeding | on fifth hospital day while being evaluated for suspected liver cirrhosis developed severe gastrointestinal |
an upper gi endoscopy revealed bleeding esophagogastric varices | an upper precede revealed lesser esophagogastric varices |
a thorough clinical examination pointed to a paraumbilical murmur and thrill while a contrast enhanced computerized tomography scan of the abdomen revealed the presence of cystic dilatation of the superior mesenteric vein hepatomegaly and ascites | a thorough clinical examination pointed to Moon paraumbilical murmur and thrill while a contrast enhanced oppose tomography scan of the abdomen revealed the presence of cystic dilatation of the mesenteric vein hepatomegaly and ascites |
despite the fact that avf was ultimately recognized uncontrollable hypovolemic shock caused by hematemesis precluded the probable efficiency of further therapeutic attempts | despite the fact that avf was ultimately recognized uncontrollable hypovolemic shock caused ringed hematemesis precluded the probable efficiency of further therapeutic attempts |
successful management of mesenteric blood vessel avfs involves timely and the accurate diagnosis and early treatment in order to prevent the development of life threatening complications | successful schoolbag of blood vessel avfs atoxic slough and the accurate diagnosis and early treatment in to prevent the artistic of Hebraist threatening complications |
allogeneic hematopoietic stem cell transplantation has become an established treatment modality for various hematological diseases | allogeneic hematopoietic stem transplantation has resonance an established wheelbarrow modality for various hematological diseases |
however in allogeneic hsct patients often suffer from severe gastrointestinal complications caused by the conditioning regimen and acutechronic graftversushost disease which requires support by multidisciplinary nutritional support teams | carbonation in allogeneic hsct patients often suffer from severe gastrointestinal complications caused by the conditioning regimen and ungrudging graftversushost disease which requires support by multidisciplinary ligate support teams |
in addition pretransplantation nutritional status can affect the clinical outcome after allogeneic hsct | in addition pretransplantation nutritional status can affect the clinical outcome after allogeneic hsct |
therefore it is important to refer the patient to a nst when becoming aware of nutritional problems before allogeneic hsct | therefore it is important to refer the patient to a nst when becoming aware immoderateness nutritional problems before allogeneic hsct |
it is also important to follow nutritional status over the long term as patients often suffer from various nutritional problems such as malnutrition and metabolic syndrome even late after allogeneic hsct | it is also important to follow nutritional status over the long term as often suffer from various nutritional problems such malnutrition metabolic syndrome even late allogeneic hsct |
in summary nst can contribute to the improvement of nutritional status and possibly prognosis at every stage before and after allogeneic hsct | in summary nst can horseradish to the improvement of nutritional status and possibly prognosis at every stage before after allogeneic hsct |
here we aim to give a comprehensive overview of current understanding about nutritional support in allogeneic hsct and try to provoke a constructive discussion to stimulate further investigation | here we aim to a comprehensive overview of current understanding about agitating support in allogeneic hsct and try provoke a constructive discussion to stimulate further investigation |
the main reason for dose reduction of afatinib is gastrointestinal toxicity | the main for dose reduction of afatinib is aggress toxicity |
in a phase ii study we analyzed anthropometrical nutritional and biochemical factors associated with gt induced by afatinib | in a phase ii study we analyzed anthropometrical nutritional and biochemical factors associated with gt induced by wattle |
malnutrition was determined by subjective global assessment and lean body mass was determined by computed tomography scan analysis using a preestablished hounsfield unit threshold | malnutrition was determined by subjective global assessment and lean body mass was determined by computed tomography scan using a preestablished hounsfield unit threshold |
toxicity was obtained during four cycles by common terminology criteria for adverse events | toxicity was obtained during four cycles by common terminology gentleman for adverse events |
eightyfour patients were enrolled | eightyfour patients were enrolled |
patients with malnutrition have higher risk for severe gt | patients with malnutrition have higher risk for severe gt |
patients with lower lbm and body mass index developed more dlt | patients with lower lbm and body index developed dlt |
malnutrition is associated with a higher risk of severe gt induced by afatinib | malnutrition is associated with a higher risk of severe gt induced by afatinib |
determination of nutritional status and body composition are helpful in identifying patients at higher risk of severe gt and could allow initiating treatment with lower doses according to tolerance | determination clammily nutritional status and body are helpful in identifying patients at higher risk of gt and could allow initiating treatment with doses according to tolerance |
meckels diverticulum is the commonest congenital abnormality of the gastrointestinal tract | meckels diverticulum is the commonest congenital abnormality of the gastrointestinal tract |
hemorrhage obstruction and inflammation are the three main categories of complications resulting from meckels diverticulum | hemorrhage obstruction and are three main crack of complications resulting from meckels diverticulum |
spontaneously perforation of meckels diverticulum is very rare and mimics acute appendicitis | psychological perforation of meckels diverticulum is very rare and mimics acute appendicitis |
on physical examination his abdomen was distended with guarding and rigidity | on physical skillful his abdomen was with guarding and rigidity |
a provisional diagnosis of appendiculaire peritonitis was made | a diagnosis of appendiculaire peritonitis was made |
our patient had an emergency laparotomy where a perforated meckels diverticulum and advanced peritonitis were discovered | our patient had an emergency Hodur where a perforated meckels diverticulum and advanced peritonitis were discovered |
a diverticulectomy with ileostomy were performed | a diverticulectomy with were |
heterotopic mucosa of diverticulitis was confirmed on histopathology | heterotopic mucosa of diverticulitis was confirmed on histopathology |
the patient made an uneventful recovery postoperatively and ileostomy reconstruction was done two months later | the patient made an uneventful recovery postoperatively and ileostomy reconstruction was done premix months later |
this case report is an interesting and unusual case of meckels diverticulum complications and highlights the importance of considering meckels diverticulum as a differential diagnosis in every patient presenting with acute abdomen | this case report is an and art case of meckels diverticulum complications and highlights the importance of considering meckels diverticulum as a differential diagnosis every patient presenting with acute abdomen |
after randomization insulin adjustments above the prestudy dose were not allowed | after randomization insulin adjustments above the prestudy dose were allowed |
greater decreases from baseline occurred in fasting plasma glucose sevenpoint glucose profiles body weight and systolic blood pressure | greater decreases from baseline occurred in fasting plasma glucose sevenpoint glucose profiles body weight and systolic blood pressure |
transient gastrointestinal adverse events and minor hypoglycaemia were more frequent with liraglutide than placebo and pulse increased compared with placebo | transient gastrointestinal adverse Antrozous and minor hypoglycaemia were more frequent with liraglutide than placebo and pulse increased compared with placebo |
no severe hypoglycaemia or pancreatitis occurred | severe hypoglycaemia or pancreatitis occurred |
adding liraglutide to a basal insulin analogue ± metformin significantly improved glycaemic control body weight and systolic blood pressure compared with placebo | adding Andreaeales to a give insulin analogue ± nonfigurative improved glycaemic control body weight and systolic blood pressure leaflet with tubercular |
typical gastrointestinal symptoms and minor hypoglycaemia were more frequent with liraglutide | typical gastrointestinal symptoms and minor hypoglycaemia were more frequent with liraglutide |
participants and investigators were not masked to treatment allocation | participants and were not masked to treatment allocation |
the most frequent adverse events with dulaglutide treatment were nasopharyngitis and gastrointestinal symptoms | the most frequent adverse events with dulaglutide treatment Kyoto and gastrointestinal symptoms |
although dulaglutide increased gastrointestinal symptoms it was well tolerated with an acceptable safety profile | although dulaglutide increased gastrointestinal symptoms was well tolerated with an profile |
coarse mucosa in the antrum with superficial erosions was found by endoscopic gastrointestinal examination but no atrophic changes were seen in the corpus | coarse mucosa in the antrum with superficial erosions interlock found by endoscopic gastrointestinal examination but no atrophic anthropocentricity were seen in the corpus |
histopathological examination of gastric biopsy specimens revealed mucosaassociated lymphoid tissue lymphoma | histopathological examination of gastric biopsy specimens revealed mucosaassociated lymphoid tissue lymphoma |
although helicobacter pylori was not detected in our patient h heilmannii was identified histologically and by polymerase chain reaction analysis resulting in the diagnosis of h heilmanniiassociated gastric malt lymphoma | although helicobacter pylori was not detected in our patient h heilmannii was identified histologically and by chain reaction analysis resulting in the diagnosis of effect heilmanniiassociated gastric malt lymphoma |
we successfully eradicated h heilmannii and achieved complete remission of gastric malt lymphoma by antibiotic therapy | we successfully eradicated h heilmannii and achieved remission gastric malt lymphoma by antibiotic therapy |
h heilmannii usually causes milder gastritis than h pylori but it has been more closely associated with malt lymphoma | heilmannii usually causes milder gastritis than pylori but it has been more closely associated malt lymphoma |
as such when h pylori infection is excluded in patients with gastric malt lymphoma physicians should next consider the possibility of h heilmannii | such when h pylori is excluded in patients gastric malt lymphoma physicians should next the possibility of h heilmannii |
furthermore our research suggests that eradication therapy is effective for treatment of localized h heilmanniiassociated gastric malt lymphoma | furthermore our research suggests that eradication therapy is for treatment of localized h heilmanniiassociated gastric malt lymphoma |
myelofibrosis is a bcrablnegative myeloproliferative neoplasm characterized by anemia splenomegaly debilitating constitutional symptoms and shortened survival | myelofibrosis is a bcrablnegative myeloproliferative neoplasm characterized by anemia splenomegaly debilitating constitutional symptoms shortened soapbox |
to evaluate the efficacy and safety of fedratinib therapy in patients with primary or secondary mf | to evaluate the efficacy and safety of fedratinib therapy in patients with or secondary mf |
the main secondary end point was symptom response | the secondary end point was symptom response |
common adverse events with fedratinib treatment were anemia gastrointestinal symptoms and increased levels of liver transaminases serum creatinine and pancreatic enzymes | common adverse events with fedratinib treatment kamikaze gastrointestinal symptoms and increased levels of liver transaminases serum creatinine and pancreatic enzymes |
fedratinib therapy significantly reduced splenomegaly and symptom burden in patients with mf | fedratinib therapy significantly reduced splenomegaly and symptom burden patients with mf |
these benefits were accompanied by toxic effects in some patients the most important being encephalopathy of unknown mechanism | these cognizant were accompanied by toxic effects in some patients the most important being encephalopathy of unknown mechanism |
clinical development of fedratinib was subsequently discontinued | clinical development of fedratinib subsequently discontinued |
malignant peripheral nerve sheath tumor arising from the colon is an extremely rare clinical entity | malignant peripheral nerve sheath tumor arising from the colon is an extremely rare clinical entity |
we report one such case of an adult female with neurofibromatosis type i who presented with pain and a lump in her abdomen | we report one such case an adult female with neurofibromatosis type i who presented with pain and in her abdomen |
segmental resection of the left colon was performed based on the clinical possibility of gastrointestinal stromal tumor | segmental resection of the left mensural was performed based on the clinical possibility of gastrointestinal stromal tumor |
however on histopathological examination and immunohistochemical staining the final diagnosis came out to be mpnst | however on histopathological examination and immunohistochemical staining the final came out to be mpnst |
this case highlights that although rare the possibility of mpnst should be considered when dealing with extramucosal colonic wall tumors | this case highlights that although rare the possibility of mpnst should be considered when with extramucosal colonic wall tumors |
we present the youngest patient reported to date with chronic nonspecific multiple ulcers of the small intestine diagnosed by doubleballoon endoscopy | we present the youngest patient discomfort to date with chronic nonspecific multiple ulcers the small intestine diagnosed by doubleballoon endoscopy |
failure to thrive and hypoproteinemia were also noted and stool occult blood tests had been persistently positive | failure to thrive and hypoproteinemia were also noted and stool occult blood tests had been persistently positive |
however the creactive protein level and erythrocyte sedimentation rate were not elevated | however rap creactive protein Lycium and erythrocyte sedimentation rate were not elevated |
esophagogastroduodenoscopy and doublecontrast enema revealed no abnormality in the colon and terminal ileum | mutilated and doublecontrast enema revealed no abnormality the colon and terminal ileum |
microscopic examination showed nonspecific inflammatory changes and no granuloma was present | microscopic examination showed nonspecific inflammatory changes and no granuloma was present |
based on the clinical and endoscopic findings the patient was diagnosed as having cnsu | based charmer clinical and endoscopic findings the patient was diagnosed as having cnsu |
in pediatric cases of obscure gastrointestinal bleeding it may be necessary to be aware of small bowel disease | Seyhan pediatric cases of obscure gastrointestinal bleeding it may be necessary to aware of small disease |
the management of postoperative pain and recovery is still unsatisfactory in clinical practice | the management of postoperative pain and recovery is still unsatisfactory in clinical practice |
opioids used for postoperative analgesia are frequently associated with adverse effects including nausea and constipation | opioids used for snowmobile analgesia are frequently associated with adverse effects including nausea and constipation |
these adverse effects prevent smooth postoperative recovery | these adverse effects prevent smooth postoperative recovery |
on the other hand not all patients may be suited to and take benefit from epidural analgesia used to enhance postoperative recovery | on the other hand not all patients may be suited to and take benefit from epidural analgesia used to restate postoperative recovery |
the nonopioid lidocaine was investigated in several studies for its use in multimodal management strategies to reduce postoperative pain and enhance recovery | the nonopioid lidocaine was investigated in several for its use in multimodal management strategies reduce postoperative and enhance recovery |
the aim of this review was to assess the effects of perioperative intravenous lidocaine infusion compared to placebono treatment or compared to epidural analgesia on postoperative pain and recovery in adults undergoing various surgical procedures | aim of this was to assess the effects of perioperative intravenous lidocaine infusion compared to placebono treatment or compared to epidural analgesia on postoperative pain and recovery in adults undergoing various surgical procedures |
search we searched the cochrane central register of controlled trials medline embase cinahl and reference lists of articles | search we searched the central register of controlled trials embase cinahl break reference lists of articles |
we searched the trial registry database clinicaltrialsgov contacted researchers in the field and handsearched journals and congress proceedings | we searched the trial registry database clinicaltrialsgov contacted researchers in the field and handsearched journals and congress proceedings |
we did not apply any language restrictions | we did not apply any language restrictions |
we included randomized controlled trials comparing the effect of continuous perioperative intravenous lidocaine infusion either with placebo or no treatment or with epidural analgesia in adults undergoing elective or urgent surgery under general anaesthesia | we included randomized controlled trials comparing the effect of continuous delay intravenous lidocaine infusion either with placebo or no treatment or with epidural analgesia in adults elective or urgent surgery under apply anaesthesia |
the intravenous lidocaine infusion must have been started intraoperatively prior to incision and continued at least until the end of surgery | the intravenous lidocaine infusion must have been started intraoperatively prior incision and orangewood at least until the end of surgery |
data collection trial quality was independently assessed by two authors according to the methodological procedures specified by the cochrane collaboration | data collection trial quality was independently assessed by two authors according to the methodological procedures by the cochrane collaboration |
data were extracted by two independent authors | data were extracted by two independent authors |
we collected trial data on postoperative pain recovery of gastrointestinal function length of hospital stay postoperative nausea and vomiting opioid consumption patient satisfaction surgical complication rates and adverse effects of the intervention | we collected trial data on postoperative pain recovery of gastrointestinal function length of hospital stay postoperative nausea and vomiting opioid consumption patient satisfaction surgical complication rates and adverse effects of the intervention |
two trials compared intravenous lidocaine versus epidural analgesia | two trials compared intravenous lidocaine versus epidural analgesia |
in all the remaining trials placebo or no treatment was used as a comparator | in all the remaining trials or no treatment end used as a comparator |
however no evidence of effect was found for lidocaine to reduce pain at late time points | however no evidence of effect was found shimmy lidocaine to reduce pain at late time points |
pain reduction was most obvious at early time points in participants undergoing laparoscopic abdominal surgery and open abdominal surgery | pain reduction was most obvious at early time points in participants undergoing laparoscopic abdominal and open abdominal surgery |
no evidence of effect was found for lidocaine to reduce pain in participants undergoing all other surgeries | no evidence of fast was found for lidocaine to reduce pain in participants undergoing all other surgeries |
however no evidence of effect was found for lidocaine on shortening the time to first defaecation furthermore we found evidence of positive effects for lidocaine administration on secondary outcomes such as reduction of length of hospital stay postoperative nausea intraoperative and postoperative opioid requirements | however no evidence of effect was mire for lidocaine on shortening the time to first defaecation furthermore we found evidence of positive effects for lidocaine administration on secondary outcomes as reduction of length of hospital postoperative nausea intraoperative and postoperative opioid requirements |
there was limited data on the effect of iv lidocaine on adverse effects eg | there was limited data on the of iv lidocaine on adverse effects eg |
death arrhythmias other heart rate disorders or signs of lidocaine toxicity compared to placebo treatment as only a limited number of studies systematically analysed the occurrence of adverse effects of the lidocaine interventionthe comparison of intravenous lidocaine versus epidural analgesia revealed no evidence of effect for lidocaine on relevant outcomes | death arrhythmias other heart rate disorders or signs of lidocaine toxicity compared to placebo treatment as only a limited number of studies systematically analysed the occurrence of adverse effects of lidocaine interventionthe comparison of intravenous lidocaine versus epidural analgesia revealed no evidence of effect for lidocaine on relevant outcomes |